format-version: 1.2 date: 23:05:2008 18:26 auto-generated-by: ONTO-PERL subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_goa "GOA and proteome slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" subsetdef: Drugable "Drugable Genome Project" subsetdef: PSI-MI slim "Subset of PSI-MI" synonymtypedef: systematic_synonym "Systematic synonym" EXACT synonymtypedef: PSI-MI-alternate "Alternate label curated by PSI-MI" EXACT synonymtypedef: PSI-MI-short "Unique short label curated by PSI-MI" EXACT default-namespace: cellcycle_ontology_h_sapiens remark: Merged ontology [Term] id: CCO:B0000000 name: core cell cycle protein def: "A protein being considered as principal in the regulation of the cell cycle process" [CCO:cco_team] is_a: CCO:U0000007 ! cell cycle protein [Term] id: CCO:B0001317 name: E2F8_HUMAN def: "Transcription factor E2F8" [UniProtKB:A0AVK6] synonym: "E2F-8" EXACT [UniProtKB:A0AVK6] xref: EMBL:AAH28244.1 xref: EMBL:AAH90877.1 xref: EMBL:AAI08701.1 xref: EMBL:AAI26401.1 xref: EMBL:AAI26403.1 xref: EMBL:BAB15605.1 xref: EMBL:BAE46901.1 xref: UniProtKB:A0AVK6 xref: UniProtKB:Q2VPJ3 xref: UniProtKB:Q3C1U6 xref: UniProtKB:Q5BKY4 xref: UniProtKB:Q8N340 xref: UniProtKB:Q9H5M0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004540 ! E2F8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001318 name: A4D1Y2_HUMAN def: "Similar to cell division cycle 10 homolog" [UniProtKB:A4D1Y2] xref: EMBL:EAL23974.1 xref: UniProtKB:A4D1Y2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005978 ! LOC392884_human relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001319 name: A6NC65_HUMAN def: "Septin" [UniProtKB:A6NC65] xref: UniProtKB:A6NC65 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005591 ! SEPT8_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001321 name: A6NE16_HUMAN def: "Uncharacterized protein ENSP00000330459" [UniProtKB:A6NE16] xref: UniProtKB:A6NE16 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001324 name: A6NFQ9_HUMAN def: "Septin" [UniProtKB:A6NFQ9] xref: UniProtKB:A6NFQ9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005591 ! SEPT8_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001328 name: A6NHZ8_HUMAN def: "Uncharacterized protein ENSP00000368241" [UniProtKB:A6NHZ8] xref: UniProtKB:A6NHZ8 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0003204 ! cyclin-dependent protein kinase regulator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001333 name: A6NK88_HUMAN def: "Uncharacterized protein CDKN1C" [UniProtKB:A6NK88] xref: UniProtKB:A6NK88 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004311 ! CDKN1C_human relationship: has_function CCO:F0001217 ! cyclin-dependent protein kinase inhibitor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001334 name: SAC31_HUMAN def: "SAC3 domain-containing protein 1" [UniProtKB:A6NKF1] synonym: "SAC3 homology domain-containing protein 1" EXACT [UniProtKB:A6NKF1] xref: UniProtKB:A6NKF1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005558 ! SAC3D1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013954 ! SAC31_HUMAN-Phosphoserine401 [Term] id: CCO:B0001335 name: A6NKP6_HUMAN def: "Septin" [UniProtKB:A6NKP6] xref: UniProtKB:A6NKP6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005591 ! SEPT8_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001337 name: A6NLT8_HUMAN def: "Uncharacterized protein SPO11" [UniProtKB:A6NLT8] xref: UniProtKB:A6NLT8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005664 ! SPO11_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000296 ! chromosome relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001339 name: A6NMH6_HUMAN def: "Septin" [UniProtKB:A6NMH6] xref: UniProtKB:A6NMH6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005591 ! SEPT8_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001340 name: A6NMK2_HUMAN def: "Uncharacterized protein HORMAD1" [UniProtKB:A6NMK2] xref: UniProtKB:A6NMK2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004824 ! HORMAD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001341 name: A6NMP7_HUMAN def: "Uncharacterized protein MAD2L1BP" [UniProtKB:A6NMP7] xref: UniProtKB:A6NMP7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005047 ! MAD2L1BP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis [Term] id: CCO:B0001343 name: A7KMP4_HUMAN def: "Truncated cyclin-dependent kinase inhibitor 1B" [UniProtKB:A7KMP4] xref: EMBL:ABS17636.1 xref: UniProtKB:A7KMP4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004310 ! CDKN1B_human relationship: has_function CCO:F0001217 ! cyclin-dependent protein kinase inhibitor activity relationship: has_function CCO:F0003114 ! kinase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001344 name: APBB1_HUMAN def: "Amyloid beta A4 precursor protein-binding family B member 1" [UniProtKB:O00213] synonym: "Fe65 protein" EXACT [UniProtKB:O00213] xref: EMBL:AAB93631.1 xref: EMBL:AAC79942.1 xref: EMBL:AAH10854.1 xref: UniProtKB:O00213 xref: UniProtKB:Q96A93 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004076 ! APBB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006279 ! app-apbb1-2 physical interaction relationship: participates_in CCO:I0007060 ! apbb1-aplp2-1 physical interaction relationship: participates_in CCO:I0007061 ! apbb1-app physical interaction relationship: participates_in CCO:I0007411 ! app-apbb1-6 physical interaction relationship: participates_in CCO:I0007604 ! app-nsf-1 physical interaction relationship: participates_in CCO:I0007620 ! atxn1-apbb1 physical interaction relationship: participates_in CCO:I0007621 ! atxn1-apbb1-1 physical interaction relationship: participates_in CCO:I0007727 ! app-apbb1-5 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000244 ! negative regulation of S phase of mitotic cell cycle [Term] id: CCO:B0001345 name: SPT5H_HUMAN def: "Transcription elongation factor SPT5" [UniProtKB:O00267] synonym: "DRB sensitivity-inducing factor large subunit" EXACT [UniProtKB:O00267] synonym: "DSIF large subunit" EXACT [UniProtKB:O00267] synonym: "DSIF p160" EXACT [UniProtKB:O00267] synonym: "hSPT5" EXACT [UniProtKB:O00267] synonym: "Tat-cotransactivator 1 protein" EXACT [UniProtKB:O00267] synonym: "Tat-CT1 protein" EXACT [UniProtKB:O00267] xref: EMBL:AAC51102.1 xref: EMBL:AAD02179.1 xref: EMBL:AAH24203.1 xref: EMBL:BAA24075.1 xref: EMBL:BAD92494.1 xref: EMBL:CAA73326.1 xref: UniProtKB:O00267 xref: UniProtKB:O43279 xref: UniProtKB:Q59G52 xref: UniProtKB:Q99639 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005666 ! SUPT5H_human relationship: has_function CCO:F0000298 ! transcription elongation regulator activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001750 ! negative transcription elongation factor activity relationship: has_function CCO:F0001753 ! positive transcription elongation factor activity relationship: has_function CCO:F0004208 ! enzyme binding relationship: has_function CCO:F0006299 ! protein heterodimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: participates_in CCO:I0007885 ! supt5h-ppia-1 physical interaction relationship: participates_in CCO:I0008056 ! supt5h-med31 physical interaction relationship: participates_in CCO:I0008170 ! supt5h-kiaa1377 physical interaction relationship: participates_in CCO:I0008171 ! supt5h-rpl8 physical interaction relationship: participates_in CCO:I0008327 ! supt5h-c9orf78 physical interaction relationship: participates_in CCO:I0008328 ! supt5h-gtf3c1 physical interaction relationship: participates_in CCO:I0008329 ! supt5h-ik physical interaction relationship: participates_in CCO:I0008330 ! supt5h-loc56902 physical interaction relationship: participates_in CCO:I0008331 ! supt5h-phyhip physical interaction relationship: participates_in CCO:I0008332 ! supt5h-ppia physical interaction relationship: participates_in CCO:I0008434 ! supt5h-dbn1 physical interaction relationship: participates_in CCO:I0008508 ! supt5h-h2afx physical interaction relationship: participates_in CCO:I0008509 ! supt5h-iqwd1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014178 ! SPT5H_HUMAN-Phosphoserine666 relationship: transforms_into CCO:B0014179 ! SPT5H_HUMAN-dimethylarginine681 relationship: transforms_into CCO:B0014180 ! SPT5H_HUMAN-Omega-N-methylarginine681 relationship: transforms_into CCO:B0014181 ! SPT5H_HUMAN-dimethylarginine696 relationship: transforms_into CCO:B0014182 ! SPT5H_HUMAN-Omega-N-methylarginine696 relationship: transforms_into CCO:B0014183 ! SPT5H_HUMAN-dimethylarginine698 relationship: transforms_into CCO:B0014184 ! SPT5H_HUMAN-Omega-N-methylarginine698 relationship: transforms_into CCO:B0014185 ! SPT5H_HUMAN-Phosphothreonine709 relationship: transforms_into CCO:B0014186 ! SPT5H_HUMAN-Phosphotyrosine717 relationship: transforms_into CCO:B0014187 ! SPT5H_HUMAN-Phosphothreonine775 relationship: transforms_into CCO:B0014188 ! SPT5H_HUMAN-Phosphothreonine784 relationship: transforms_into CCO:B0014189 ! SPT5H_HUMAN-Phosphothreonine1034 [Term] id: CCO:B0001346 name: CDC7_HUMAN def: "Cell division cycle 7-related protein kinase" [UniProtKB:O00311] synonym: "CDC7-related kinase" EXACT [UniProtKB:O00311] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O00311] synonym: "HsCdc7" EXACT [UniProtKB:O00311] synonym: "huCdc7" EXACT [UniProtKB:O00311] xref: EMBL:AAB97512.1 xref: EMBL:AAC52080.1 xref: EMBL:AAI10527.1 xref: EMBL:AAI10528.1 xref: EMBL:AAI11045.1 xref: EMBL:AAS79323.1 xref: EMBL:BAA19962.1 xref: EMBL:CAI14446.1 xref: UniProtKB:O00311 xref: UniProtKB:O00558 xref: UniProtKB:Q5T5U5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004294 ! CDC7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006090 ! orc6l-cdc7 direct interaction relationship: participates_in CCO:I0006092 ! mcm10-cdc7 direct interaction relationship: participates_in CCO:I0006137 ! cdkn1a-cdc7 direct interaction relationship: participates_in CCO:I0006138 ! cdc7-orc5l direct interaction relationship: participates_in CCO:I0006141 ! cdkn2a-cdc7 direct interaction relationship: participates_in CCO:I0006146 ! mcm3-cdc7 direct interaction relationship: participates_in CCO:I0006162 ! cdc7-cdk4 direct interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000215 ! regulation of S phase [Term] id: CCO:B0001347 name: FOXN3_HUMAN def: "Forkhead box protein N3" [UniProtKB:O00409] synonym: "Checkpoint suppressor 1" EXACT [UniProtKB:O00409] xref: EMBL:AAB58252.1 xref: EMBL:AAF18259.1 xref: EMBL:AAH07506.1 xref: UniProtKB:O00409 xref: UniProtKB:Q96II7 xref: UniProtKB:Q9UIE7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004655 ! FOXN3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006483 ! exosc8-ches1 physical interaction relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: participates_in CCO:P0000015 ! G2 phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011889 ! FOXN3_HUMAN-Phosphoserine85 [Term] id: CCO:B0001349 name: BIN1_HUMAN def: "Myc box-dependent-interacting protein 1" [UniProtKB:O00499] synonym: "Amphiphysin II" EXACT [UniProtKB:O00499] synonym: "Amphiphysin-like protein" EXACT [UniProtKB:O00499] synonym: "Box-dependent myc-interacting protein 1" EXACT [UniProtKB:O00499] synonym: "Bridging integrator 1" EXACT [UniProtKB:O00499] xref: EMBL:AAB61363.1 xref: EMBL:AAB63263.1 xref: EMBL:AAC17461.1 xref: EMBL:AAC23440.1 xref: EMBL:AAC23441.1 xref: EMBL:AAC23750.1 xref: EMBL:AAC23751.1 xref: EMBL:AAC24126.1 xref: EMBL:AAC24127.1 xref: EMBL:AAC24128.1 xref: EMBL:AAC28646.1 xref: EMBL:AAC39710.1 xref: EMBL:AAC39711.1 xref: EMBL:AAC39712.1 xref: EMBL:AAC39713.1 xref: EMBL:AAC51345.1 xref: UniProtKB:O00297 xref: UniProtKB:O00499 xref: UniProtKB:O00545 xref: UniProtKB:O43867 xref: UniProtKB:O60552 xref: UniProtKB:O60553 xref: UniProtKB:O60554 xref: UniProtKB:O60555 xref: UniProtKB:O75514 xref: UniProtKB:O75515 xref: UniProtKB:O75516 xref: UniProtKB:O75517 xref: UniProtKB:O75518 xref: UniProtKB:Q92944 xref: UniProtKB:Q99688 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004163 ! BIN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008379 ! cutl1-bin1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0010794 ! BIN1_HUMAN-Phosphoserine296 relationship: transforms_into CCO:B0010795 ! BIN1_HUMAN-Phosphoserine298 relationship: transforms_into CCO:B0010796 ! BIN1_HUMAN-Phosphoserine303 relationship: transforms_into CCO:B0010797 ! BIN1_HUMAN-Phosphothreonine307 relationship: transforms_into CCO:B0010798 ! BIN1_HUMAN-Phosphoserine331 [Term] id: CCO:B0001350 name: LHR2A_HUMAN def: "Loss of heterozygosity 11 chromosomal region 2 gene A protein" [UniProtKB:O00534] synonym: "BCSC-1" EXACT [UniProtKB:O00534] synonym: "Breast cancer suppressor candidate 1" EXACT [UniProtKB:O00534] xref: EMBL:AAB60942.1 xref: EMBL:AAH01234.1 xref: EMBL:AAP35301.1 xref: EMBL:AAQ94867.1 xref: EMBL:AAQ94868.1 xref: EMBL:AAQ94869.1 xref: EMBL:AAQ94871.1 xref: EMBL:AAQ94872.1 xref: EMBL:AAQ94873.1 xref: EMBL:AAQ94874.1 xref: EMBL:AAQ94875.1 xref: EMBL:AAQ94876.1 xref: UniProtKB:O00534 xref: UniProtKB:Q6UN19 xref: UniProtKB:Q6UN20 xref: UniProtKB:Q9BVF8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004979 ! LOH11CR2A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001352 name: E2F3_HUMAN def: "Transcription factor E2F3" [UniProtKB:O00716] synonym: "E2F-3" EXACT [UniProtKB:O00716] xref: EMBL:AAN17846.1 xref: EMBL:BAA07553.1 xref: EMBL:CAA71504.1 xref: EMBL:CAC28598.2 xref: EMBL:CAI21471.1 xref: UniProtKB:O00716 xref: UniProtKB:Q15000 xref: UniProtKB:Q9BZ44 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004535 ! E2F3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001353 name: PPP6_HUMAN def: "Serine/threonine-protein phosphatase 6" [UniProtKB:O00743] synonym: "EC 3.1.3.16" EXACT [UniProtKB:O00743] synonym: "PP6" EXACT [UniProtKB:O00743] xref: EMBL:AAD45400.2 xref: EMBL:AAH06990.1 xref: EMBL:AAV38514.1 xref: EMBL:CAA63549.1 xref: EMBL:CAI13677.1 xref: EMBL:EAW87611.1 xref: UniProtKB:O00743 xref: UniProtKB:Q5U0A2 xref: UniProtKB:Q9UIC9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005370 ! PPP6C_human relationship: has_function CCO:F0001086 ! phosphoprotein phosphatase activity relationship: has_function CCO:F0001087 ! protein serine/threonine phosphatase activity relationship: has_function CCO:F0001643 ! iron ion binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:I0006429 ! nfkbie-ppp6c physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001354 name: UBE2C_HUMAN def: "Ubiquitin-conjugating enzyme E2 C" [UniProtKB:O00762] synonym: "EC 6.3.2.19" EXACT [UniProtKB:O00762] synonym: "UbcH10" EXACT [UniProtKB:O00762] synonym: "Ubiquitin carrier protein C" EXACT [UniProtKB:O00762] synonym: "Ubiquitin-protein ligase C" EXACT [UniProtKB:O00762] xref: EMBL:AAB53362.1 xref: EMBL:AAH07656.1 xref: EMBL:AAH16292.1 xref: EMBL:AAH50736.1 xref: EMBL:AAP35964.1 xref: EMBL:CAB66118.1 xref: UniProtKB:O00762 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005860 ! UBE2C_human relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0003433 ! ligase activity relationship: has_function CCO:F0004170 ! small conjugating protein ligase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:I0008386 ! eno2-ube2c physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000141 ! cyclin catabolic process relationship: participates_in CCO:P0000177 ! positive regulation of exit from mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0001355 name: CDKA1_HUMAN def: "Cyclin-dependent kinase 2-associated protein 1" [UniProtKB:O14519] synonym: "CDK2-associated protein 1" EXACT [UniProtKB:O14519] synonym: "Deleted in oral cancer 1" EXACT [UniProtKB:O14519] synonym: "DOC-1" EXACT [UniProtKB:O14519] synonym: "Putative oral cancer suppressor" EXACT [UniProtKB:O14519] xref: EMBL:AAC77831.1 xref: EMBL:AAH34717.1 xref: EMBL:BAA22937.1 xref: UniProtKB:O14519 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004307 ! CDK2AP1_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001225 ! signal transducer activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000014 ! S phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001356 name: CTRO_HUMAN def: "Citron Rho-interacting kinase" [UniProtKB:O14578] synonym: "CRIK" EXACT [UniProtKB:O14578] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O14578] synonym: "Rho-interacting, serine/threonine-protein kinase 21" EXACT [UniProtKB:O14578] xref: EMBL:AAB71327.1 xref: EMBL:AAP13528.1 xref: EMBL:AAP43922.1 xref: EMBL:BAA76793.2 xref: UniProtKB:O14578 xref: UniProtKB:Q6XUH8 xref: UniProtKB:Q86UQ9 xref: UniProtKB:Q9UPZ7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004420 ! CIT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011406 ! CTRO_HUMAN-Phosphoserine440 relationship: transforms_into CCO:B0011407 ! CTRO_HUMAN-Phosphoserine480 relationship: transforms_into CCO:B0011408 ! CTRO_HUMAN-Phosphoserine1582 relationship: transforms_into CCO:B0011409 ! CTRO_HUMAN-Phosphoserine1971 relationship: transforms_into CCO:B0011410 ! CTRO_HUMAN-Phosphoserine1993 relationship: transforms_into CCO:B0031308 ! CTRO_HUMAN-Phosphotyrosine1196 relationship: transforms_into CCO:B0031309 ! CTRO_HUMAN-Phosphotyrosine1478 [Term] id: CCO:B0001357 name: ANM5_HUMAN def: "Protein arginine N-methyltransferase 5" [UniProtKB:O14744] synonym: "72 kDa ICln-binding protein" EXACT [UniProtKB:O14744] synonym: "EC 2.1.1.-" EXACT [UniProtKB:O14744] synonym: "EC 2.1.1.125" EXACT [UniProtKB:O14744] synonym: "Jak-binding protein 1" EXACT [UniProtKB:O14744] synonym: "Shk1 kinase-binding protein 1 homolog" EXACT [UniProtKB:O14744] synonym: "SKB1Hs" EXACT [UniProtKB:O14744] xref: EMBL:AAB66581.1 xref: EMBL:AAF04502.1 xref: EMBL:AAH25979.1 xref: EMBL:CAG33022.1 xref: UniProtKB:O14744 xref: UniProtKB:Q6IBR1 xref: UniProtKB:Q9UKH1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004065 ! PRMT5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:I0008416 ! phyhip-skb1 physical interaction relationship: participates_in CCO:I0008421 ! ptd004-skb1 physical interaction relationship: participates_in CCO:P0000099 ! regulation of mitosis relationship: transforms_into CCO:B0041110 ! ANM5_HUMAN-N-acetylalanine2 [Term] id: CCO:B0001359 name: CHK1_HUMAN def: "Serine/threonine-protein kinase Chk1" [UniProtKB:O14757] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O14757] xref: EMBL:AAB88852.1 xref: EMBL:AAC51736.1 xref: EMBL:AAH04202.1 xref: EMBL:AAH17575.1 xref: EMBL:AAM78553.1 xref: EMBL:BAA84577.1 xref: UniProtKB:O14757 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004347 ! CHEK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006255 ! chek1-aatf phosphorylation relationship: participates_in CCO:I0007377 ! cdc25c-chek1-1 phosphorylation relationship: participates_in CCO:I0007800 ! hspcb-chk1-1 physical interaction relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000122 ! meiotic recombination relationship: transforms_into CCO:B0011212 ! CHK1_HUMAN-Phosphoserine280 relationship: transforms_into CCO:B0011213 ! CHK1_HUMAN-Phosphoserine296 relationship: transforms_into CCO:B0011214 ! CHK1_HUMAN-Phosphoserine308 relationship: transforms_into CCO:B0011215 ! CHK1_HUMAN-Phosphoserine317 relationship: transforms_into CCO:B0011216 ! CHK1_HUMAN-Phosphoserine345 [Term] id: CCO:B0001360 name: NDC80_HUMAN def: "Kinetochore protein NDC80 homolog" [UniProtKB:O14777] synonym: "Highly expressed in cancer protein" EXACT [UniProtKB:O14777] synonym: "HsHec1" EXACT [UniProtKB:O14777] synonym: "Kinetochore protein Hec1" EXACT [UniProtKB:O14777] synonym: "Kinetochore-associated protein 2" EXACT [UniProtKB:O14777] synonym: "Retinoblastoma-associated protein HEC" EXACT [UniProtKB:O14777] xref: EMBL:AAB80726.1 xref: EMBL:AAH10171.1 xref: UniProtKB:O14777 xref: UniProtKB:Q6PJX2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006415 ! NDC80_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005764 ! kntc2-pldn physical interaction relationship: participates_in CCO:I0005899 ! kntc2-ushbp1 physical interaction relationship: participates_in CCO:I0005911 ! amotl2-kntc2 physical interaction relationship: participates_in CCO:I0006064 ! kntc2-spbc25-1 physical interaction relationship: participates_in CCO:I0006065 ! kntc2-spbc25-2 physical interaction relationship: participates_in CCO:I0006066 ! kntc2_zwint_5 physical interaction relationship: participates_in CCO:I0006226 ! kntc2_cenpb_1 colocalization relationship: participates_in CCO:I0006446 ! kntc2_zwint_6 colocalization relationship: participates_in CCO:I0006755 ! kntc2_zwint_4 colocalization relationship: participates_in CCO:I0006757 ! kntc2_zw10_2 colocalization relationship: participates_in CCO:I0006764 ! kntc2-spbc24-3 physical interaction relationship: participates_in CCO:I0006765 ! kntc2-spbc25-4 physical interaction relationship: participates_in CCO:I0006791 ! kntc2_zwint_1 physical interaction relationship: participates_in CCO:I0006908 ! kntc2-spbc25-3 physical interaction relationship: participates_in CCO:I0006909 ! cenph_kntc2_2 physical interaction relationship: participates_in CCO:I0006910 ! cenph_kntc2_4 physical interaction relationship: participates_in CCO:I0007156 ! kntc2-cdca1-4 physical interaction relationship: participates_in CCO:I0007157 ! kntc2_zwint_2 physical interaction relationship: participates_in CCO:I0007158 ! zwint_kntc2_2 physical interaction relationship: participates_in CCO:I0007159 ! kntc2_zwint_3 physical interaction relationship: participates_in CCO:I0007160 ! zw10_kntc2_1 physical interaction relationship: participates_in CCO:I0007161 ! zwint_kntc2_3 physical interaction relationship: participates_in CCO:I0007162 ! zw10_kntc2_2 physical interaction relationship: participates_in CCO:I0007169 ! kntc2-spbc24-4 physical interaction relationship: participates_in CCO:I0007301 ! kntc2-spbc24-1 physical interaction relationship: participates_in CCO:I0007303 ! kntc2-cdca1-3 physical interaction relationship: participates_in CCO:I0007318 ! cdca1-kntc2 physical interaction relationship: participates_in CCO:I0007456 ! cenph_kntc2_1 physical interaction relationship: participates_in CCO:I0007463 ! kntc2-cdca1-2 physical interaction relationship: participates_in CCO:I0007473 ! kntc2-cdca1-1 physical interaction relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction relationship: participates_in CCO:I0007932 ! kntc2-spbc24-2 physical interaction relationship: participates_in CCO:I0008258 ! kntc2-tom1l1 physical interaction relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0031343 ! NDC80_HUMAN-Phosphoserine55 relationship: transforms_into CCO:B0031344 ! NDC80_HUMAN-Phosphoserine62 relationship: transforms_into CCO:B0031345 ! NDC80_HUMAN-Phosphoserine76 relationship: transforms_into CCO:B0031346 ! NDC80_HUMAN-Phosphoserine77 relationship: transforms_into CCO:B0031347 ! NDC80_HUMAN-Phosphoserine165 [Term] id: CCO:B0001361 name: O14835_HUMAN def: "Dim1p homolog" [UniProtKB:O14835] synonym: "Thioredoxin-like 4A, isoform CRA_a" EXACT [UniProtKB:O14835] xref: EMBL:AAB81951.1 xref: EMBL:EAW66639.1 xref: UniProtKB:O14835 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005847 ! TXNL4A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000283 ! spliceosome relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001362 name: EREG_HUMAN def: "Proepiregulin precursor" [UniProtKB:O14944] xref: EMBL:BAA22146.1 xref: EMBL:CAG46685.1 xref: UniProtKB:O14944 xref: UniProtKB:Q6FH69 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004581 ! EREG_human relationship: has_function CCO:F0001456 ! epidermal growth factor receptor binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001702 ! growth factor activity relationship: has_function CCO:F0006299 ! protein heterodimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000201 ! extracellular region relationship: located_in CCO:C0000237 ! extracellular space relationship: located_in CCO:C0000445 ! integral to plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: participates_in CCO:P0000134 ! female meiosis relationship: participates_in CCO:P0000251 ! positive regulation of mitosis [Term] id: CCO:B0001363 name: STK6_HUMAN def: "Serine/threonine-protein kinase 6" [UniProtKB:O14965] synonym: "Aurora kinase A" EXACT [UniProtKB:O14965] synonym: "Aurora-A" EXACT [UniProtKB:O14965] synonym: "Aurora-related kinase 1" EXACT [UniProtKB:O14965] synonym: "Aurora/IPL1-related kinase 1" EXACT [UniProtKB:O14965] synonym: "Breast tumor-amplified kinase" EXACT [UniProtKB:O14965] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O14965] synonym: "hARK1" EXACT [UniProtKB:O14965] synonym: "Serine/threonine kinase 15" EXACT [UniProtKB:O14965] xref: EMBL:AAC12708.1 xref: EMBL:AAC23448.1 xref: EMBL:AAC63902.1 xref: EMBL:AAF29508.1 xref: EMBL:AAH01280.1 xref: EMBL:AAH02499.1 xref: EMBL:AAH06423.1 xref: EMBL:AAH27464.1 xref: EMBL:BAA23592.1 xref: EMBL:CAC12717.1 xref: UniProtKB:O14965 xref: UniProtKB:O60445 xref: UniProtKB:O75873 xref: UniProtKB:Q9BQD6 xref: UniProtKB:Q9UPG5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005695 ! AURKA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006317 ! tacc1-chtog-8 colocalization relationship: participates_in CCO:I0006704 ! akip-stk6-1 physical interaction relationship: participates_in CCO:I0007021 ! stk6-tpx2-1 direct interaction relationship: participates_in CCO:I0007077 ! akip-stk6-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014257 ! STK6_HUMAN-Phosphoserine369 relationship: transforms_into CCO:B0041199 ! STK6_HUMAN-Phosphothreonine287 relationship: transforms_into CCO:B0041200 ! STK6_HUMAN-Phosphothreonine288 [Term] id: CCO:B0001364 name: GAK_HUMAN def: "Cyclin G-associated kinase" [UniProtKB:O14976] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O14976] xref: EMBL:AAH00816.1 xref: EMBL:AAH08668.1 xref: EMBL:BAA22623.1 xref: UniProtKB:O14976 xref: UniProtKB:Q9BVY6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004681 ! GAK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006664 ! npm_alk-gak physical interaction relationship: participates_in CCO:I0008198 ! axin1-gak physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011920 ! GAK_HUMAN-Phosphoserine829 [Term] id: CCO:B0001365 name: TBX3_HUMAN def: "T-box transcription factor TBX3" [UniProtKB:O15119] synonym: "T-box protein 3" EXACT [UniProtKB:O15119] xref: EMBL:AAC12947.1 xref: EMBL:AAD50989.2 xref: EMBL:AAF61207.1 xref: EMBL:AAF61816.1 xref: EMBL:AAH25258.1 xref: UniProtKB:O15119 xref: UniProtKB:Q8TB20 xref: UniProtKB:Q9UKF8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005747 ! TBX3_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0000291 ! RNA polymerase II transcription factor activity relationship: has_function CCO:F0003206 ! transcription repressor activity relationship: has_function CCO:F0003207 ! general transcriptional repressor activity relationship: has_function CCO:F0005877 ! sequence-specific DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000247 ! positive regulation of cell cycle relationship: transforms_into CCO:B0014321 ! TBX3_HUMAN-Phosphoserine375 relationship: transforms_into CCO:B0014322 ! TBX3_HUMAN-Phosphoserine456 [Term] id: CCO:B0001366 name: MDM4_HUMAN def: "Mdm4 protein" [UniProtKB:O15151] synonym: "Double minute 4 protein" EXACT [UniProtKB:O15151] synonym: "Mdm2-like p53-binding protein" EXACT [UniProtKB:O15151] synonym: "p53-binding protein Mdm4" EXACT [UniProtKB:O15151] synonym: "Protein Mdmx" EXACT [UniProtKB:O15151] xref: EMBL:AAB62928.1 xref: EMBL:AAH67299.1 xref: EMBL:AAO13494.1 xref: EMBL:BAD96948.1 xref: EMBL:CAI14100.1 xref: UniProtKB:O15151 xref: UniProtKB:Q6GS18 xref: UniProtKB:Q8IV83 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005053 ! MDM4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006016 ! mdm2-mdm4-1 physical interaction relationship: participates_in CCO:I0007339 ! mdm2-mdm4-2 physical interaction relationship: participates_in CCO:I0007340 ! mdm2-mdm4-3 physical interaction relationship: participates_in CCO:I0007407 ! mdm2-mdm4-4 physical interaction relationship: participates_in CCO:P0000235 ! G0 to G1 transition [Term] id: CCO:B0001367 name: AXN1_HUMAN def: "Axin-1" [UniProtKB:O15169] synonym: "Axis inhibition protein 1" EXACT [UniProtKB:O15169] synonym: "hAxin" EXACT [UniProtKB:O15169] xref: EMBL:AAC51624.1 xref: EMBL:AAH17447.1 xref: EMBL:AAH44648.1 xref: EMBL:AAK61224.1 xref: EMBL:CAI95589.2 xref: EMBL:CAI95590.2 xref: EMBL:CAI95600.2 xref: EMBL:CAI95601.2 xref: UniProtKB:O15169 xref: UniProtKB:Q4TT26 xref: UniProtKB:Q4TT27 xref: UniProtKB:Q86YA7 xref: UniProtKB:Q8WVW6 xref: UniProtKB:Q96S28 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004133 ! AXIN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007886 ! axin1-anp32a-1 physical interaction relationship: participates_in CCO:I0007887 ! axin1-crmp1 physical interaction relationship: participates_in CCO:I0007997 ! axin1-crmp1-1 physical interaction relationship: participates_in CCO:I0007998 ! axin1-eef1a1 physical interaction relationship: participates_in CCO:I0008071 ! axin1-anp32a physical interaction relationship: participates_in CCO:I0008197 ! axin1-axin1 physical interaction relationship: participates_in CCO:I0008198 ! axin1-gak physical interaction relationship: participates_in CCO:I0008199 ! axin1-utp14a physical interaction relationship: participates_in CCO:I0008449 ! axin1-sh3gl1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001368 name: CETN3_HUMAN def: "Centrin-3" [UniProtKB:O15182] xref: EMBL:AAH05383.1 xref: EMBL:AAH93793.1 xref: EMBL:AAI12041.1 xref: EMBL:AAP35334.1 xref: EMBL:CAA73077.1 xref: UniProtKB:O15182 xref: UniProtKB:Q53YD2 xref: UniProtKB:Q9BS23 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004334 ! CETN3_human relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000384 ! centriole relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction relationship: participates_in CCO:I0008085 ! cetn3-pde6d physical interaction relationship: participates_in CCO:I0008086 ! cetn3-rif1 physical interaction relationship: participates_in CCO:I0008087 ! cetn3-unc119 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000108 ! centrosome cycle [Term] id: CCO:B0001369 name: MK13_HUMAN def: "Mitogen-activated protein kinase 13" [UniProtKB:O15264] synonym: "EC 2.7.11.24" EXACT [UniProtKB:O15264] synonym: "MAP kinase p38 delta" EXACT [UniProtKB:O15264] synonym: "Mitogen-activated protein kinase p38 delta" EXACT [UniProtKB:O15264] synonym: "Stress-activated protein kinase 4" EXACT [UniProtKB:O15264] xref: EMBL:AAB87639.1 xref: EMBL:AAC51374.1 xref: EMBL:AAC51758.1 xref: EMBL:AAD23377.1 xref: EMBL:AAF36772.1 xref: EMBL:AAH00433.1 xref: EMBL:AAH01641.1 xref: EMBL:AAH04428.1 xref: EMBL:AAP35885.1 xref: EMBL:CAA71512.1 xref: EMBL:CAB08438.1 xref: UniProtKB:O14739 xref: UniProtKB:O15124 xref: UniProtKB:O15264 xref: UniProtKB:Q9UNU0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005096 ! MAPK13_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001073 ! MAP kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001844 ! MP kinase activity relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012959 ! MK13_HUMAN-Phosphothreonine180 relationship: transforms_into CCO:B0012960 ! MK13_HUMAN-Phosphotyrosine182 relationship: transforms_into CCO:B0041160 ! MK13_HUMAN-Phosphoserine47 [Term] id: CCO:B0001370 name: FANCG_HUMAN def: "Fanconi anemia group G protein" [UniProtKB:O15287] synonym: "DNA-repair protein XRCC9" EXACT [UniProtKB:O15287] synonym: "Protein FACG" EXACT [UniProtKB:O15287] xref: EMBL:AAB80802.1 xref: EMBL:AAC07981.1 xref: EMBL:AAH00032.1 xref: EMBL:AAH11623.1 xref: EMBL:AAV40841.1 xref: EMBL:CAA07602.1 xref: EMBL:CAH70994.1 xref: UniProtKB:O15287 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004611 ! FANCG_human relationship: has_function CCO:F0000279 ! damaged DNA binding relationship: has_function CCO:F0001633 ! binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0005768 ! fancg-gabpb2 physical interaction relationship: participates_in CCO:I0005796 ! fancg-zbed1x physical interaction relationship: participates_in CCO:I0005841 ! fancg-samd3 physical interaction relationship: participates_in CCO:I0005909 ! fancg-ushbp1 physical interaction relationship: participates_in CCO:I0005959 ! fanca-fancg physical interaction relationship: participates_in CCO:I0007402 ! fance-fanca-1 physical interaction relationship: participates_in CCO:I0007403 ! fance-fanca-2 physical interaction relationship: participates_in CCO:I0007587 ! fancg-fancf-1 physical interaction relationship: participates_in CCO:P0000006 ! cell cycle checkpoint [Term] id: CCO:B0001371 name: LX15B_HUMAN def: "Arachidonate 15-lipoxygenase type II" [UniProtKB:O15296] synonym: "15-lipoxygenase 2" EXACT [UniProtKB:O15296] synonym: "15-LOX-2" EXACT [UniProtKB:O15296] synonym: "EC 1.13.11.33" EXACT [UniProtKB:O15296] xref: EMBL:AAB61706.1 xref: EMBL:AAD37786.1 xref: EMBL:AAH35217.1 xref: EMBL:AAH63647.1 xref: EMBL:AAL76274.1 xref: EMBL:AAL76275.1 xref: EMBL:AAL76276.1 xref: EMBL:AAL76277.1 xref: EMBL:CAC34521.1 xref: UniProtKB:O15296 xref: UniProtKB:Q8IYQ2 xref: UniProtKB:Q8TEV3 xref: UniProtKB:Q8TEV4 xref: UniProtKB:Q8TEV5 xref: UniProtKB:Q8TEV6 xref: UniProtKB:Q9UKM4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004997 ! ALOX15B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001372 name: PPM1D_HUMAN def: "Protein phosphatase 1D" [UniProtKB:O15297] synonym: "EC 3.1.3.16" EXACT [UniProtKB:O15297] synonym: "p53-induced protein phosphatase 1" EXACT [UniProtKB:O15297] synonym: "PP2C-delta" EXACT [UniProtKB:O15297] synonym: "Protein phosphatase 2C isoform delta" EXACT [UniProtKB:O15297] synonym: "Protein phosphatase magnesium-dependent 1 delta" EXACT [UniProtKB:O15297] xref: EMBL:AAB61637.1 xref: EMBL:AAH16480.1 xref: UniProtKB:O15297 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005367 ! PPM1D_human relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0001086 ! phosphoprotein phosphatase activity relationship: has_function CCO:F0001087 ! protein serine/threonine phosphatase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000541 ! protein serine/threonine phosphatase complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001373 name: RA51B_HUMAN def: "DNA repair protein RAD51 homolog 2" [UniProtKB:O15315] synonym: "R51H2" EXACT [UniProtKB:O15315] synonym: "RAD51-like protein 1" EXACT [UniProtKB:O15315] synonym: "Rad51B" EXACT [UniProtKB:O15315] xref: EMBL:AAB63358.1 xref: EMBL:AAC32425.1 xref: EMBL:AAC32426.1 xref: EMBL:AAC39723.1 xref: EMBL:AAH30219.1 xref: EMBL:AAN60542.1 xref: EMBL:AAN60543.1 xref: EMBL:AAN60544.1 xref: EMBL:AAZ85144.1 xref: EMBL:CAA75680.1 xref: EMBL:CAD61950.1 xref: EMBL:CAD62357.1 xref: EMBL:CAD66573.1 xref: UniProtKB:O15315 xref: UniProtKB:O60914 xref: UniProtKB:O75210 xref: UniProtKB:Q3Y4F8 xref: UniProtKB:Q86SY3 xref: UniProtKB:Q86SY4 xref: UniProtKB:Q86TR0 xref: UniProtKB:Q86U92 xref: UniProtKB:Q86U93 xref: UniProtKB:Q86U94 xref: UniProtKB:Q8N6H4 xref: UniProtKB:Q9UPL5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005406 ! RAD51L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001374 name: P73_HUMAN def: "Tumor protein p73" [UniProtKB:O15350] synonym: "p53-like transcription factor" EXACT [UniProtKB:O15350] synonym: "p53-related protein" EXACT [UniProtKB:O15350] xref: EMBL:AAC61887.1 xref: EMBL:AAD39696.1 xref: EMBL:AAI17252.1 xref: EMBL:AAI17254.1 xref: EMBL:AAK81884.1 xref: EMBL:AAK81885.1 xref: EMBL:AAK81886.1 xref: EMBL:BAB87244.1 xref: EMBL:BAB87245.1 xref: EMBL:CAA72219.1 xref: EMBL:CAA72220.1 xref: EMBL:CAA72221.1 xref: EMBL:CAI19123.1 xref: EMBL:CAI19124.1 xref: EMBL:CAI19125.1 xref: EMBL:CAI19126.1 xref: EMBL:CAI19127.1 xref: UniProtKB:O15350 xref: UniProtKB:O15351 xref: UniProtKB:Q17RN8 xref: UniProtKB:Q5TBV5 xref: UniProtKB:Q5TBV6 xref: UniProtKB:Q8NHW9 xref: UniProtKB:Q8TDY5 xref: UniProtKB:Q8TDY6 xref: UniProtKB:Q9NTK8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005248 ! TP73_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007526 ! hmgb1-tp73-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013361 ! P73_HUMAN-Phosphotyrosine99 [Term] id: CCO:B0001375 name: PPM1G_HUMAN def: "Protein phosphatase 1G" [UniProtKB:O15355] synonym: "EC 3.1.3.16" EXACT [UniProtKB:O15355] synonym: "PP2C-gamma" EXACT [UniProtKB:O15355] synonym: "Protein phosphatase 1C" EXACT [UniProtKB:O15355] synonym: "Protein phosphatase 2C isoform gamma" EXACT [UniProtKB:O15355] synonym: "Protein phosphatase magnesium-dependent 1 gamma" EXACT [UniProtKB:O15355] xref: EMBL:AAH00057.1 xref: EMBL:AAH22061.1 xref: EMBL:CAA74245.1 xref: UniProtKB:O15355 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005368 ! PPM1G_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007052 ! mit1b-ef1-fila-1 physical interaction relationship: participates_in CCO:I0008482 ! lrpap1-ppm1g physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0013605 ! PPM1G_HUMAN-Phosphoserine183 relationship: transforms_into CCO:B0013606 ! PPM1G_HUMAN-Phosphoserine527 [Term] id: CCO:B0001376 name: HDAC3_HUMAN def: "Histone deacetylase 3" [UniProtKB:O15379] synonym: "EC 3.5.1.98" EXACT [UniProtKB:O15379] synonym: "HD3" EXACT [UniProtKB:O15379] synonym: "RPD3-2" EXACT [UniProtKB:O15379] synonym: "SMAP45" EXACT [UniProtKB:O15379] xref: EMBL:AAB87752.1 xref: EMBL:AAB88240.1 xref: EMBL:AAB88241.1 xref: EMBL:AAC08351.1 xref: EMBL:AAC08352.1 xref: EMBL:AAC26509.1 xref: EMBL:AAC52038.1 xref: EMBL:AAC98927.1 xref: EMBL:AAH00614.1 xref: UniProtKB:O15379 xref: UniProtKB:O43268 xref: UniProtKB:Q9UEI5 xref: UniProtKB:Q9UEV0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004788 ! HDAC3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007191 ! hdac3-brms1 physical interaction [Term] id: CCO:B0001377 name: BIRC5_HUMAN def: "Baculoviral IAP repeat-containing protein 5" [UniProtKB:O15392] synonym: "Apoptosis inhibitor 4" EXACT [UniProtKB:O15392] synonym: "Apoptosis inhibitor survivin" EXACT [UniProtKB:O15392] xref: EMBL:AAC51660.1 xref: EMBL:AAD34226.1 xref: EMBL:AAH08718.1 xref: EMBL:AAH34148.1 xref: EMBL:AAH65497.1 xref: EMBL:AAV40840.1 xref: EMBL:AAW22624.1 xref: EMBL:AAY15202.1 xref: EMBL:ABC42341.1 xref: EMBL:ABC42342.1 xref: EMBL:ABC42343.1 xref: EMBL:ABC42344.1 xref: EMBL:ABC42345.1 xref: EMBL:BAA93676.1 xref: EMBL:BAD11155.1 xref: EMBL:BAD97148.1 xref: EMBL:CAG46540.1 xref: UniProtKB:O15392 xref: UniProtKB:Q2I3N8 xref: UniProtKB:Q4VGX0 xref: UniProtKB:Q53F61 xref: UniProtKB:Q5MGC6 xref: UniProtKB:Q6FHL2 xref: UniProtKB:Q75SP2 xref: UniProtKB:Q9P2W8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004166 ! BIRC5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007348 ! birc5-casp9 physical interaction relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000177 ! positive regulation of exit from mitosis relationship: participates_in CCO:P0000190 ! spindle checkpoint relationship: participates_in CCO:P0000259 ! positive regulation of mitotic cell cycle relationship: transforms_into CCO:B0010799 ! BIRC5_HUMAN-Phosphothreonine34 [Term] id: CCO:B0001378 name: MSH4_HUMAN def: "MutS protein homolog 4" [UniProtKB:O15457] xref: EMBL:AAB72039.1 xref: EMBL:AAD17920.1 xref: EMBL:AAH33030.1 xref: EMBL:AAP03427.1 xref: UniProtKB:O15457 xref: UniProtKB:Q8NEB3 xref: UniProtKB:Q9UNP8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005128 ! MSH4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001380 name: ZZEF1_HUMAN def: "Zinc finger ZZ-type and EF-hand domain-containing protein 1" [UniProtKB:O43149] xref: EMBL:AAH67099.1 xref: EMBL:BAA23695.4 xref: EMBL:BAA91834.1 xref: EMBL:BAC86999.1 xref: EMBL:BAC87412.1 xref: UniProtKB:O43149 xref: UniProtKB:Q6NXG0 xref: UniProtKB:Q6ZRA1 xref: UniProtKB:Q6ZSF4 xref: UniProtKB:Q9NVB9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005977 ! ZZEF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition relationship: transforms_into CCO:B0014779 ! ZZEF1_HUMAN-Phosphoserine1464 relationship: transforms_into CCO:B0014780 ! ZZEF1_HUMAN-Phosphoserine2444 [Term] id: CCO:B0001381 name: MSH5_HUMAN def: "MutS protein homolog 5" [UniProtKB:O43196] xref: EMBL:AAB87632.1 xref: EMBL:AAC62533.1 xref: EMBL:AAC62534.1 xref: EMBL:AAC70066.1 xref: EMBL:AAC70067.1 xref: EMBL:AAD18072.1 xref: EMBL:AAD21822.1 xref: EMBL:AAH01358.1 xref: EMBL:AAH02498.1 xref: EMBL:AAH41031.1 xref: EMBL:AAP35864.1 xref: EMBL:AAX20111.1 xref: EMBL:BAB63375.1 xref: EMBL:CAI17723.1 xref: EMBL:CAI17724.1 xref: EMBL:CAI18423.1 xref: EMBL:CAI18424.1 xref: UniProtKB:O43196 xref: UniProtKB:O60586 xref: UniProtKB:Q5BLU9 xref: UniProtKB:Q5SSR1 xref: UniProtKB:Q8IW44 xref: UniProtKB:Q9BQC7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005129 ! MSH5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000122 ! meiotic recombination relationship: participates_in CCO:P0000127 ! meiotic prophase II [Term] id: CCO:B0001382 name: SEPT4_HUMAN def: "Septin-4" [UniProtKB:O43236] synonym: "Bradeion beta" EXACT [UniProtKB:O43236] synonym: "Brain protein H5" EXACT [UniProtKB:O43236] synonym: "CE5B3 beta" EXACT [UniProtKB:O43236] synonym: "Cell division control-related protein 2" EXACT [UniProtKB:O43236] synonym: "Cerebral protein 7" EXACT [UniProtKB:O43236] synonym: "hCDCREL-2" EXACT [UniProtKB:O43236] synonym: "Peanut-like protein 2" EXACT [UniProtKB:O43236] xref: EMBL:AAB88512.1 xref: EMBL:AAC25673.1 xref: EMBL:AAD00653.1 xref: EMBL:AAD00657.1 xref: EMBL:AAH18056.3 xref: EMBL:BAB46922.1 xref: EMBL:BAB70695.1 xref: EMBL:CAG33392.1 xref: EMBL:EAW94440.1 xref: UniProtKB:O43236 xref: UniProtKB:Q6IAP3 xref: UniProtKB:Q9UM58 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005587 ! SEPT4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013995 ! SEPT4_HUMAN-Phosphoserine325 [Term] id: CCO:B0001383 name: KLK10_HUMAN def: "Kallikrein-10 precursor" [UniProtKB:O43240] synonym: "EC 3.4.21.-" EXACT [UniProtKB:O43240] synonym: "Normal epithelial cell-specific 1" EXACT [UniProtKB:O43240] synonym: "Protease serine-like 1" EXACT [UniProtKB:O43240] xref: EMBL:AAB81602.1 xref: EMBL:AAC14266.1 xref: EMBL:AAG23256.1 xref: EMBL:AAG33363.1 xref: EMBL:AAH02710.1 xref: UniProtKB:O43240 xref: UniProtKB:Q99920 xref: UniProtKB:Q9GZW9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004954 ! KLK10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008402 ! klk10-rif1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001384 name: SIAH2_HUMAN def: "E3 ubiquitin-protein ligase SIAH2" [UniProtKB:O43255] synonym: "EC 6.3.2.-" EXACT [UniProtKB:O43255] synonym: "hSiah2" EXACT [UniProtKB:O43255] synonym: "Seven in absentia homolog 2" EXACT [UniProtKB:O43255] synonym: "Siah-2" EXACT [UniProtKB:O43255] xref: EMBL:AAC51908.1 xref: EMBL:AAH13082.1 xref: EMBL:CAA75557.1 xref: UniProtKB:O43255 xref: UniProtKB:O43270 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005613 ! SIAH2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007617 ! atn1-siah2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001385 name: LEU1_HUMAN def: "Leukemia-associated protein 1" [UniProtKB:O43261] synonym: "Deleted in lymphocytic leukemia 1" EXACT [UniProtKB:O43261] xref: EMBL:AAH20692.1 xref: EMBL:AAL95698.1 xref: EMBL:CAA75515.1 xref: EMBL:CAA75600.1 xref: EMBL:CAC43393.1 xref: UniProtKB:O43261 xref: UniProtKB:Q8TE10 xref: UniProtKB:Q96QY5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004977 ! DLEU1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007576 ! htatip-dleu1-1 physical interaction relationship: participates_in CCO:I0007985 ! dleu1-eef1a1 physical interaction relationship: participates_in CCO:I0007986 ! dleu1-eef1g physical interaction relationship: participates_in CCO:I0008092 ! dleu1-med31 physical interaction relationship: participates_in CCO:I0008093 ! dleu1-cops6 physical interaction relationship: participates_in CCO:I0008094 ! dleu1-htatip physical interaction relationship: participates_in CCO:I0008095 ! dleu1-kiaa1377 physical interaction relationship: participates_in CCO:I0008096 ! dleu1-utp14a physical interaction relationship: participates_in CCO:I0008097 ! dleu1-tp53 physical interaction relationship: participates_in CCO:I0008098 ! dleu1-ubr1 physical interaction relationship: participates_in CCO:I0008219 ! dleu1-psma1 physical interaction relationship: participates_in CCO:I0008220 ! dleu1-setdb1 physical interaction relationship: participates_in CCO:I0008221 ! dleu1-shmt1 physical interaction relationship: participates_in CCO:I0008222 ! dleu1-tle1 physical interaction relationship: participates_in CCO:I0008381 ! dleu1-abcd4 physical interaction relationship: participates_in CCO:I0008382 ! dleu1-gdf9 physical interaction relationship: participates_in CCO:I0008467 ! dleu1-arl10c physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001386 name: LEU2_HUMAN def: "Leukemia-associated protein 2" [UniProtKB:O43262] synonym: "Deleted in lymphocytic leukemia 2" EXACT [UniProtKB:O43262] xref: EMBL:CAA75516.1 xref: UniProtKB:O43262 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004978 ! DLEU2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001387 name: ZW10_HUMAN def: "Centromere/kinetochore protein zw10 homolog" [UniProtKB:O43264] xref: EMBL:AAB88237.1 xref: UniProtKB:O43264 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005973 ! ZW10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006066 ! kntc2_zwint_5 physical interaction relationship: participates_in CCO:I0006447 ! zw10_zwint_2 colocalization relationship: participates_in CCO:I0006750 ! zwint_zw10_2 colocalization relationship: participates_in CCO:I0006751 ! mad1l1_zw10_1 colocalization relationship: participates_in CCO:I0006752 ! zw10_bub1_1 colocalization relationship: participates_in CCO:I0006753 ! zw10_bub1b_2 colocalization relationship: participates_in CCO:I0006754 ! zw10_dync1l1_1 colocalization relationship: participates_in CCO:I0006756 ! zw10_zwint_1 colocalization relationship: participates_in CCO:I0006757 ! kntc2_zw10_2 colocalization relationship: participates_in CCO:I0007158 ! zwint_kntc2_2 physical interaction relationship: participates_in CCO:I0007159 ! kntc2_zwint_3 physical interaction relationship: participates_in CCO:I0007160 ! zw10_kntc2_1 physical interaction relationship: participates_in CCO:I0007819 ! zw10_zwilch_1 physical interaction relationship: participates_in CCO:I0007820 ! zwint_zw10_1 physical interaction relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: transforms_into CCO:B0041345 ! ZW10_HUMAN-N-acetylalanine2 [Term] id: CCO:B0001388 name: SNUT1_HUMAN def: "U4/U6.U5 tri-snRNP-associated protein 1" [UniProtKB:O43290] synonym: "Allergen Hom s 1" EXACT [UniProtKB:O43290] synonym: "hSART-1" EXACT [UniProtKB:O43290] synonym: "hSnu66" EXACT [UniProtKB:O43290] synonym: "SART-1" EXACT [UniProtKB:O43290] synonym: "Squamous cell carcinoma antigen recognized by T cells 1" EXACT [UniProtKB:O43290] synonym: "U4/U6.U5 tri-snRNP-associated 110 kDa protein" EXACT [UniProtKB:O43290] xref: EMBL:AAD20223.1 xref: EMBL:AAH01058.1 xref: EMBL:AAK49523.1 xref: EMBL:AAP35283.1 xref: EMBL:BAA24056.1 xref: EMBL:BAD96736.1 xref: UniProtKB:A6NDN1 xref: UniProtKB:O43290 xref: UniProtKB:Q53GB5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005646 ! SART1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007564 ! ubl5-sart1-1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0014144 ! SNUT1_HUMAN-Phosphothreonine392 relationship: transforms_into CCO:B0014145 ! SNUT1_HUMAN-Phosphothreonine430 relationship: transforms_into CCO:B0014146 ! SNUT1_HUMAN-Phosphoserine448 relationship: transforms_into CCO:B0014147 ! SNUT1_HUMAN-Phosphoserine591 relationship: transforms_into CCO:B0014148 ! SNUT1_HUMAN-Phosphoserine596 relationship: transforms_into CCO:B0014149 ! SNUT1_HUMAN-Phosphoserine598 relationship: transforms_into CCO:B0014150 ! SNUT1_HUMAN-Phosphothreonine695 [Term] id: CCO:B0001389 name: CE110_HUMAN def: "Centrosomal protein of 110 kDa" [UniProtKB:O43303] synonym: "Cep110" EXACT [UniProtKB:O43303] xref: EMBL:AAC05804.1 xref: EMBL:AAH36654.1 xref: EMBL:BAA24849.2 xref: EMBL:CAH18111.1 xref: UniProtKB:O43303 xref: UniProtKB:O43335 xref: UniProtKB:Q68DV9 xref: UniProtKB:Q8NE13 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004316 ! CEP110_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000300 ! centrosome duplication relationship: transforms_into CCO:B0011130 ! CE110_HUMAN-Phosphoserine641 [Term] id: CCO:B0001390 name: MTSS1_HUMAN def: "Metastasis suppressor protein 1" [UniProtKB:O43312] synonym: "Metastasis suppressor YGL-1" EXACT [UniProtKB:O43312] synonym: "Missing in metastasis protein" EXACT [UniProtKB:O43312] xref: EMBL:AAF15947.1 xref: EMBL:AAH23998.1 xref: EMBL:BAA24859.3 xref: UniProtKB:O43312 xref: UniProtKB:Q8TCA2 xref: UniProtKB:Q96RX2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005136 ! MTSS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006183 ! hd-mtss1 physical interaction relationship: participates_in CCO:I0006184 ! hd-mtss1-1 physical interaction relationship: participates_in CCO:I0006185 ! hd-mtss1-2 physical interaction relationship: participates_in CCO:I0008426 ! recql5-mtss1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013036 ! MTSS1_HUMAN-Phosphothreonine258 relationship: transforms_into CCO:B0013037 ! MTSS1_HUMAN-Phosphoserine272 relationship: transforms_into CCO:B0013038 ! MTSS1_HUMAN-Phosphoserine315 relationship: transforms_into CCO:B0013039 ! MTSS1_HUMAN-Phosphoserine316 relationship: transforms_into CCO:B0013040 ! MTSS1_HUMAN-Phosphoserine569 relationship: transforms_into CCO:B0031341 ! MTSS1_HUMAN-Phosphotyrosine526 relationship: transforms_into CCO:B0041161 ! MTSS1_HUMAN-Phosphoserine261 [Term] id: CCO:B0001391 name: SUV91_HUMAN def: "Histone-lysine N-methyltransferase SUV39H1" [UniProtKB:O43463] synonym: "EC 2.1.1.43" EXACT [UniProtKB:O43463] synonym: "H3-K9-HMTase 1" EXACT [UniProtKB:O43463] synonym: "Histone H3-K9 methyltransferase 1" EXACT [UniProtKB:O43463] synonym: "Lysine N-methyltransferase 1A" EXACT [UniProtKB:O43463] synonym: "Position-effect variegation 3-9 homolog" EXACT [UniProtKB:O43463] synonym: "Su(var)3-9 homolog 1" EXACT [UniProtKB:O43463] synonym: "Suppressor of variegation 3-9 homolog 1" EXACT [UniProtKB:O43463] xref: EMBL:AAB92224.1 xref: EMBL:AAH06238.1 xref: EMBL:BAD96791.1 xref: EMBL:CAG46546.1 xref: UniProtKB:O43463 xref: UniProtKB:Q53G60 xref: UniProtKB:Q6FHK6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005706 ! SUV39H1_human relationship: has_function CCO:F0000278 ! chromatin binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001755 ! methyltransferase activity relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0003617 ! histone-lysine N-methyltransferase activity relationship: has_function CCO:F0005616 ! histone methyltransferase activity relationship: has_function CCO:F0006291 ! histone lysine N-methyltransferase activity (H3-K9 specific) relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: located_in CCO:C0000112 ! chromatin relationship: located_in CCO:C0000121 ! condensed nuclear chromosome relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000296 ! chromosome relationship: participates_in CCO:I0005942 ! cbx5-suv39h1 physical interaction relationship: participates_in CCO:I0006742 ! pml-suv39h1-2 physical interaction relationship: participates_in CCO:I0006904 ! mbde-suv93h1-1 physical interaction relationship: participates_in CCO:I0006905 ! suv93h1-mbde-1 physical interaction relationship: participates_in CCO:I0006906 ! suv93h1-mbd1-4 colocalization relationship: participates_in CCO:I0007459 ! suv39h1-hdac2-3 physical interaction relationship: participates_in CCO:I0007460 ! suv39h1-hdac1-3 physical interaction relationship: participates_in CCO:I0007726 ! h3fa-suv39h1 physical interaction relationship: participates_in CCO:I0007972 ! mbde-suv93h1-2 physical interaction relationship: participates_in CCO:I0007973 ! suv93h1-mbde-2 physical interaction relationship: participates_in CCO:I0007974 ! suv93h1-cbx-1 physical interaction relationship: participates_in CCO:I0007975 ! suv93h1-hdac1-1 physical interaction relationship: participates_in CCO:I0007976 ! suv93h1-hdac1-2 physical interaction relationship: participates_in CCO:I0007977 ! suv93h1-hdac2-1 physical interaction relationship: participates_in CCO:I0007978 ! suv93h1-hdac2-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014273 ! SUV91_HUMAN-Phosphoserine391 [Term] id: CCO:B0001392 name: XRCC2_HUMAN def: "DNA-repair protein XRCC2" [UniProtKB:O43543] synonym: "X-ray repair cross-complementing protein 2" EXACT [UniProtKB:O43543] xref: EMBL:AAC05369.1 xref: EMBL:AAC05802.1 xref: EMBL:AAH42137.1 xref: EMBL:AAM55241.1 xref: EMBL:CAA70065.1 xref: EMBL:CAA76597.1 xref: UniProtKB:O43543 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005945 ! XRCC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0014717 ! XRCC2_HUMAN-Phosphoserine247 relationship: transforms_into CCO:B0014718 ! XRCC2_HUMAN-Phosphoserine249 [Term] id: CCO:B0001393 name: O43550_HUMAN def: "Cdc25B phosphatase" [UniProtKB:O43550] xref: EMBL:AAB94625.1 xref: UniProtKB:O43550 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005118 ! CDC25B_human relationship: has_function CCO:F0001090 ! protein tyrosine phosphatase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle [Term] id: CCO:B0001394 name: PRC1_HUMAN def: "Protein regulator of cytokinesis 1" [UniProtKB:O43663] xref: EMBL:AAC02688.1 xref: EMBL:AAH03138.1 xref: EMBL:AAH05140.1 xref: UniProtKB:O43663 xref: UniProtKB:Q9BSB6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005373 ! PRC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000001 ! mitotic spindle elongation relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013608 ! PRC1_HUMAN-Phosphoserine195 relationship: transforms_into CCO:B0013609 ! PRC1_HUMAN-Phosphothreonine470 relationship: transforms_into CCO:B0013610 ! PRC1_HUMAN-Phosphothreonine481 relationship: transforms_into CCO:B0013611 ! PRC1_HUMAN-Phosphoserine592 [Term] id: CCO:B0001395 name: BUB1_HUMAN def: "Mitotic checkpoint serine/threonine-protein kinase BUB1" [UniProtKB:O43683] synonym: "BUB1A" EXACT [UniProtKB:O43683] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O43683] synonym: "hBUB1" EXACT [UniProtKB:O43683] xref: EMBL:AAB97855.2 xref: EMBL:AAC03122.1 xref: EMBL:AAC06259.1 xref: EMBL:AAC12729.1 xref: EMBL:AAC39546.1 xref: EMBL:AAD43675.1 xref: EMBL:AAH28201.1 xref: UniProtKB:O43430 xref: UniProtKB:O43643 xref: UniProtKB:O43683 xref: UniProtKB:O60626 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004199 ! BUB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005890 ! arih2-bub1 physical interaction relationship: participates_in CCO:I0006752 ! zw10_bub1_1 colocalization relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint relationship: participates_in CCO:P0000105 ! mitotic cell cycle spindle assembly checkpoint relationship: transforms_into CCO:B0010869 ! BUB1_HUMAN-Phosphoserine314 [Term] id: CCO:B0001396 name: BUB3_HUMAN def: "Mitotic checkpoint protein BUB3" [UniProtKB:O43684] xref: EMBL:AAC06258.1 xref: EMBL:AAC28438.1 xref: EMBL:AAC28439.1 xref: EMBL:AAC36307.1 xref: EMBL:AAH05138.1 xref: EMBL:AAH22438.1 xref: UniProtKB:O43684 xref: UniProtKB:O43685 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004200 ! BUB3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint relationship: participates_in CCO:P0000105 ! mitotic cell cycle spindle assembly checkpoint relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0010870 ! BUB3_HUMAN-Phosphoserine211 [Term] id: CCO:B0001398 name: TRIA1_HUMAN def: "TP53-regulated inhibitor of apoptosis 1" [UniProtKB:O43715] synonym: "p53-inducible cell-survival factor" EXACT [UniProtKB:O43715] synonym: "p53CSV" EXACT [UniProtKB:O43715] synonym: "Protein 15E1.1" EXACT [UniProtKB:O43715] synonym: "WF-1" EXACT [UniProtKB:O43715] xref: EMBL:AAF29096.1 xref: EMBL:AAH02638.1 xref: EMBL:AAH55313.1 xref: EMBL:AAR00584.1 xref: EMBL:CAA16495.1 xref: UniProtKB:O43715 xref: UniProtKB:Q5RKS5 xref: UniProtKB:Q6LCA7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005831 ! TRIAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000065 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [Term] id: CCO:B0001399 name: AKAP8_HUMAN def: "A-kinase anchor protein 8" [UniProtKB:O43823] synonym: "A-kinase anchor protein 95 kDa" EXACT [UniProtKB:O43823] synonym: "AKAP 95" EXACT [UniProtKB:O43823] xref: EMBL:AAC62838.1 xref: EMBL:CAA72722.1 xref: UniProtKB:O43823 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004042 ! AKAP8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0010482 ! AKAP8_HUMAN-Phosphoserine112 relationship: transforms_into CCO:B0010483 ! AKAP8_HUMAN-Phosphoserine323 relationship: transforms_into CCO:B0010484 ! AKAP8_HUMAN-Phosphoserine328 relationship: transforms_into CCO:B0010485 ! AKAP8_HUMAN-Phosphoserine339 [Term] id: CCO:B0001400 name: O43832_HUMAN def: "Peptidylglycine alpha-amidating monooxygenase" [UniProtKB:O43832] synonym: "EC 1.14.17.3" EXACT [UniProtKB:O43832] xref: EMBL:AAB91432.1 xref: UniProtKB:O43832 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000278 ! chromatin binding relationship: has_function CCO:F0000894 ! monooxygenase activity relationship: has_function CCO:F0000901 ! peptidylglycine monooxygenase activity relationship: has_function CCO:F0003172 ! oxidoreductase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000117 ! nuclear chromatin relationship: located_in CCO:C0000120 ! condensed chromosome relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation [Term] id: CCO:B0001401 name: GAS2_HUMAN def: "Growth arrest-specific protein 2" [UniProtKB:O43903] synonym: "GAS-2" EXACT [UniProtKB:O43903] xref: EMBL:AAC52058.1 xref: EMBL:AAH40470.1 xref: EMBL:CAG29281.1 xref: UniProtKB:O43903 xref: UniProtKB:Q6ICV8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004683 ! GAS2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000421 ! cytoskeleton relationship: located_in CCO:C0000442 ! actin filament relationship: located_in CCO:C0000766 ! membrane relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001403 name: RAD21_HUMAN def: "Double-strand-break repair protein rad21 homolog" [UniProtKB:O60216] synonym: "hHR21" EXACT [UniProtKB:O60216] synonym: "Nuclear matrix protein 1" EXACT [UniProtKB:O60216] synonym: "NXP-1" EXACT [UniProtKB:O60216] synonym: "SCC1 homolog" EXACT [UniProtKB:O60216] xref: EMBL:AAH50381.1 xref: EMBL:AAT70725.1 xref: EMBL:BAA07554.2 xref: EMBL:CAA66940.1 xref: UniProtKB:O60216 xref: UniProtKB:Q15001 xref: UniProtKB:Q99568 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005414 ! RAD21_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000040 ! nuclear chromosome relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0006601 ! disc1-rad21 physical interaction relationship: participates_in CCO:I0006783 ! rad21-stag2 physical interaction relationship: participates_in CCO:I0007038 ! smc2l1-smc4l1 physical interaction relationship: participates_in CCO:I0007039 ! wapl-cspg6-1 physical interaction relationship: participates_in CCO:I0007040 ! wapl-cspg6-2 physical interaction relationship: participates_in CCO:I0007177 ! cspg6-rad21 physical interaction relationship: participates_in CCO:I0007711 ! wapl-cspg6-4 physical interaction relationship: participates_in CCO:I0007712 ! wapl-cspg6-5 physical interaction relationship: participates_in CCO:I0007713 ! wapl-cspg6-6 physical interaction relationship: participates_in CCO:I0007714 ! wapl-cspg6-7 physical interaction relationship: participates_in CCO:I0007715 ! wapl-cspg6-9 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001405 name: SSA27_HUMAN def: "Sjoegren syndrome/scleroderma autoantigen 1" [UniProtKB:O60232] synonym: "Autoantigen p27" EXACT [UniProtKB:O60232] xref: EMBL:AAH14791.1 xref: EMBL:BAA25263.1 xref: UniProtKB:O60232 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005674 ! SSSCA1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005734 ! ccnh-sssca1 physical interaction relationship: participates_in CCO:I0005753 ! myo15b-sssca1 physical interaction relationship: participates_in CCO:I0005767 ! mgc5356-sssca1 physical interaction relationship: participates_in CCO:I0005815 ! il16-sssca1 physical interaction relationship: participates_in CCO:I0005831 ! sssca1-sssca1 physical interaction relationship: participates_in CCO:I0005836 ! cct3-sssca1 physical interaction relationship: participates_in CCO:I0005844 ! c6orf55-sssca1 physical interaction relationship: participates_in CCO:I0005879 ! mgc3162-sssca1 physical interaction relationship: participates_in CCO:I0005895 ! cct5-sssca1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014217 ! SSA27_HUMAN-Phosphoserine94 [Term] id: CCO:B0001407 name: HBP1_HUMAN def: "HMG box-containing protein 1" [UniProtKB:O60381] synonym: "High mobility group box transcription factor 1" EXACT [UniProtKB:O60381] synonym: "HMG box transcription factor 1" EXACT [UniProtKB:O60381] xref: EMBL:AAC08317.1 xref: EMBL:AAD56225.1 xref: EMBL:AAH17069.1 xref: EMBL:AAH22329.1 xref: EMBL:BAB85059.1 xref: UniProtKB:O60381 xref: UniProtKB:Q8TBM1 xref: UniProtKB:Q8TE93 xref: UniProtKB:Q96AJ2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004781 ! HBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006651 ! ewsr1-hbp1 physical interaction relationship: participates_in CCO:I0006662 ! hbp1-kiaa1279 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001408 name: EVI5_HUMAN def: "Ecotropic viral integration site 5 protein homolog" [UniProtKB:O60447] synonym: "EVI-5" EXACT [UniProtKB:O60447] synonym: "Neuroblastoma stage 4S gene protein" EXACT [UniProtKB:O60447] xref: EMBL:AAC16031.1 xref: EMBL:CAC19437.2 xref: EMBL:CAI21914.1 xref: UniProtKB:O60447 xref: UniProtKB:Q9H1Y9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004592 ! EVI5_human relationship: has_function CCO:F0001402 ! Rab GTPase activator activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000383 ! centrosome relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011773 ! EVI5_HUMAN-Phosphoserine477 relationship: transforms_into CCO:B0011774 ! EVI5_HUMAN-Phosphoserine776 relationship: transforms_into CCO:B0011775 ! EVI5_HUMAN-Phosphoserine778 [Term] id: CCO:B0001409 name: DBC1_HUMAN def: "Deleted in bladder cancer protein 1 precursor" [UniProtKB:O60477] synonym: "Protein FAM5A" EXACT [UniProtKB:O60477] xref: EMBL:AAC39691.1 xref: EMBL:AAH21560.1 xref: EMBL:AAH65196.1 xref: EMBL:AAH71702.1 xref: EMBL:CAH72027.1 xref: EMBL:CAH72028.1 xref: EMBL:CAI16000.1 xref: EMBL:CAI16001.1 xref: UniProtKB:O60477 xref: UniProtKB:Q6IPV6 xref: UniProtKB:Q6P1A0 xref: UniProtKB:Q8WU22 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004440 ! DBC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001410 name: CCNT1_HUMAN def: "Cyclin-T1" [UniProtKB:O60563] synonym: "Cyclin-T" EXACT [UniProtKB:O60563] synonym: "CycT1" EXACT [UniProtKB:O60563] xref: EMBL:AAC39638.1 xref: EMBL:AAC39664.1 xref: UniProtKB:O60563 xref: UniProtKB:O60581 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004262 ! CCNT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011006 ! CCNT1_HUMAN-N6-acetyllysine492 [Term] id: CCO:B0001411 name: BUB1B_HUMAN def: "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta" [UniProtKB:O60566] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O60566] synonym: "hBUBR1" EXACT [UniProtKB:O60566] synonym: "MAD3/BUB1-related protein kinase" EXACT [UniProtKB:O60566] synonym: "Mitotic checkpoint kinase MAD3L" EXACT [UniProtKB:O60566] synonym: "SSK1" EXACT [UniProtKB:O60566] xref: EMBL:AAC06260.1 xref: EMBL:AAC12730.2 xref: EMBL:AAC19118.1 xref: EMBL:AAC23736.1 xref: EMBL:AAC33435.1 xref: EMBL:AAD11941.1 xref: EMBL:AAL10712.1 xref: UniProtKB:O60501 xref: UniProtKB:O60566 xref: UniProtKB:O60627 xref: UniProtKB:O60758 xref: UniProtKB:O75389 xref: UniProtKB:Q96KM4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004198 ! BUB1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006449 ! zwint_bub1b_1 colocalization relationship: participates_in CCO:I0006753 ! zw10_bub1b_2 colocalization relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0035987 ! BUB1B_HUMAN-Phosphothreonine54 [Term] id: CCO:B0001412 name: CCNT2_HUMAN def: "Cyclin-T2" [UniProtKB:O60583] synonym: "CycT2" EXACT [UniProtKB:O60583] xref: EMBL:AAC39665.1 xref: EMBL:AAC39666.1 xref: EMBL:AAW56073.1 xref: EMBL:AAY14998.1 xref: UniProtKB:O60582 xref: UniProtKB:O60583 xref: UniProtKB:Q53SR4 xref: UniProtKB:Q5I1Y0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004263 ! CCNT2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011007 ! CCNT2_HUMAN-Phosphoserine480 [Term] id: CCO:B0001413 name: RAD1_HUMAN def: "Cell cycle checkpoint protein RAD1" [UniProtKB:O60671] synonym: "DNA repair exonuclease rad1 homolog" EXACT [UniProtKB:O60671] synonym: "EC 3.1.11.2" EXACT [UniProtKB:O60671] synonym: "hRAD1" EXACT [UniProtKB:O60671] synonym: "Rad1-like DNA damage checkpoint protein" EXACT [UniProtKB:O60671] xref: EMBL:AAC14138.1 xref: EMBL:AAC27243.1 xref: EMBL:AAC35549.1 xref: EMBL:AAC35550.1 xref: EMBL:AAC95427.1 xref: EMBL:AAC95466.1 xref: EMBL:AAC95523.1 xref: EMBL:AAC95603.1 xref: EMBL:AAC98093.1 xref: EMBL:AAH06837.1 xref: EMBL:AAH09804.1 xref: EMBL:AAH37857.1 xref: EMBL:AAP35554.1 xref: EMBL:BAD86789.1 xref: EMBL:BAD86790.1 xref: EMBL:CAA06248.1 xref: EMBL:CAA06249.1 xref: UniProtKB:O60671 xref: UniProtKB:O75572 xref: UniProtKB:O95304 xref: UniProtKB:Q5KSM0 xref: UniProtKB:Q5KSM1 xref: UniProtKB:Q9UEP1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005413 ! RAD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008415 ! park2-rad1 physical interaction relationship: participates_in CCO:I0008493 ! rad1-map1lc3b physical interaction relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: participates_in CCO:P0000119 ! meiotic prophase I [Term] id: CCO:B0001416 name: TRI13_HUMAN def: "Tripartite motif-containing protein 13" [UniProtKB:O60858] synonym: "B-cell chronic lymphocytic leukemia tumor suppressor Leu5" EXACT [UniProtKB:O60858] synonym: "Leukemia-associated protein 5" EXACT [UniProtKB:O60858] synonym: "Putative tumor suppressor RFP2" EXACT [UniProtKB:O60858] synonym: "Ret finger protein 2" EXACT [UniProtKB:O60858] synonym: "RING finger protein 77" EXACT [UniProtKB:O60858] xref: EMBL:AAF91315.1 xref: EMBL:AAG53500.1 xref: EMBL:AAG53501.1 xref: EMBL:AAH03579.1 xref: EMBL:AAH63407.1 xref: EMBL:AAK13059.1 xref: EMBL:AAK51624.1 xref: EMBL:AAO38979.1 xref: EMBL:AAR31110.1 xref: EMBL:CAA12136.1 xref: EMBL:CAC43391.1 xref: UniProtKB:O60858 xref: UniProtKB:Q9BQ47 xref: UniProtKB:Q9C021 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005827 ! TRIM13_human relationship: has_function CCO:F0001225 ! signal transducer activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001417 name: GAS7_HUMAN def: "Growth arrest-specific protein 7" [UniProtKB:O60861] synonym: "GAS-7" EXACT [UniProtKB:O60861] xref: EMBL:AAG26332.2 xref: EMBL:AAH01152.1 xref: EMBL:AAH06454.2 xref: EMBL:BAA23690.2 xref: EMBL:CAA12177.1 xref: UniProtKB:O43144 xref: UniProtKB:O60861 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004684 ! GAS7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001418 name: DNJA2_HUMAN def: "DnaJ homolog subfamily A member 2" [UniProtKB:O60884] synonym: "Cell cycle progression restoration gene 3 protein" EXACT [UniProtKB:O60884] synonym: "Dj3" EXACT [UniProtKB:O60884] synonym: "Dnj3" EXACT [UniProtKB:O60884] synonym: "HIRA-interacting protein 4" EXACT [UniProtKB:O60884] synonym: "Renal carcinoma antigen NY-REN-14" EXACT [UniProtKB:O60884] xref: EMBL:AAB69313.1 xref: EMBL:AAH13044.1 xref: EMBL:AAH15809.1 xref: EMBL:CAA04669.1 xref: EMBL:CAA73791.1 xref: UniProtKB:O14711 xref: UniProtKB:O60884 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004488 ! DNAJA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007836 ! cftr-ebp-2 physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle relationship: transforms_into CCO:B0011550 ! DNJA2_HUMAN-Phosphoserine78 [Term] id: CCO:B0001419 name: HUS1_HUMAN def: "Checkpoint protein HUS1" [UniProtKB:O60921] synonym: "hHUS1" EXACT [UniProtKB:O60921] xref: EMBL:AAC95526.1 xref: EMBL:AAD25350.1 xref: EMBL:AAH07013.1 xref: EMBL:AAM18968.1 xref: EMBL:AAV38288.1 xref: EMBL:AAV38289.1 xref: EMBL:CAA76518.1 xref: EMBL:CAG38789.1 xref: UniProtKB:O60921 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004843 ! HUS1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000008 ! DNA damage checkpoint [Term] id: CCO:B0001420 name: PFD1_HUMAN def: "Prefoldin subunit 1" [UniProtKB:O60925] xref: EMBL:AAH03620.1 xref: EMBL:AAH06202.1 xref: EMBL:AAH11869.1 xref: EMBL:BAD97114.1 xref: EMBL:CAA76759.1 xref: UniProtKB:O60925 xref: UniProtKB:Q53F95 xref: UniProtKB:Q96EX6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005301 ! PFDN1_human relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0008055 ! unfolded protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000777 ! prefoldin complex relationship: participates_in CCO:I0006372 ! map3k3-pfdn1 physical interaction relationship: participates_in CCO:I0008142 ! pfdn1-med31 physical interaction relationship: participates_in CCO:I0008143 ! pfdn1-git1 physical interaction relationship: participates_in CCO:I0008144 ! pfdn1-hap1 physical interaction relationship: participates_in CCO:I0008145 ! pfdn1-kiaa1377 physical interaction relationship: participates_in CCO:I0008146 ! pfdn1-rif1 physical interaction relationship: participates_in CCO:I0008147 ! pfdn1-rplp1 physical interaction relationship: participates_in CCO:I0008286 ! pfdn1-hip1 physical interaction relationship: participates_in CCO:I0008287 ! pfdn1-immt physical interaction relationship: participates_in CCO:I0008288 ! pfdn1-psme1 physical interaction relationship: participates_in CCO:I0008487 ! pfdn1-c20orf39 physical interaction relationship: participates_in CCO:I0008488 ! pfdn1-defa1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001421 name: NBN_HUMAN def: "Nibrin" [UniProtKB:O60934] synonym: "Cell cycle regulatory protein p95" EXACT [UniProtKB:O60934] synonym: "Nijmegen breakage syndrome protein 1" EXACT [UniProtKB:O60934] xref: EMBL:AAC39732.1 xref: EMBL:AAC39752.1 xref: EMBL:AAC62232.1 xref: EMBL:AAI08651.1 xref: EMBL:AAS59158.1 xref: EMBL:BAA28616.1 xref: EMBL:BAD96976.1 xref: EMBL:CAH56160.1 xref: UniProtKB:O60672 xref: UniProtKB:O60934 xref: UniProtKB:Q32NF7 xref: UniProtKB:Q53FM6 xref: UniProtKB:Q63HR6 xref: UniProtKB:Q7LDM2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005159 ! NBN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006022 ! nbs1-h2afx-2 physical interaction relationship: participates_in CCO:I0006201 ! ccne1-nbs1-1 physical interaction relationship: participates_in CCO:I0006514 ! h2afx-nbs1-1 physical interaction relationship: participates_in CCO:I0006515 ! nbs1-h2afx-1 physical interaction relationship: participates_in CCO:I0006516 ! nbs1-mre11a-1 physical interaction relationship: participates_in CCO:I0006518 ! h2afx-nbs1-2 physical interaction relationship: participates_in CCO:I0006960 ! mdc1-atm-1 physical interaction relationship: participates_in CCO:I0006961 ! nbs1-mdc1-1 physical interaction relationship: participates_in CCO:I0007342 ! h2afx-nbs1-4 physical interaction relationship: participates_in CCO:I0007538 ! h2afx-nbs1-5 physical interaction relationship: participates_in CCO:I0007851 ! h2afx-nbs1-3 physical interaction relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000106 ! mitotic cell cycle G2/M transition DNA damage checkpoint relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000188 ! G1/S transition checkpoint relationship: transforms_into CCO:B0013103 ! NBN_HUMAN-Phosphoserine278 relationship: transforms_into CCO:B0013104 ! NBN_HUMAN-Phosphoserine343 relationship: transforms_into CCO:B0013105 ! NBN_HUMAN-Phosphoserine397 relationship: transforms_into CCO:B0013106 ! NBN_HUMAN-Phosphoserine432 relationship: transforms_into CCO:B0013107 ! NBN_HUMAN-Phosphoserine615 [Term] id: CCO:B0001422 name: CLAP2_HUMAN def: "CLIP-associating protein 2" [UniProtKB:O75122] synonym: "Cytoplasmic linker-associated protein 2" EXACT [UniProtKB:O75122] synonym: "hOrbit2" EXACT [UniProtKB:O75122] xref: EMBL:AAH29035.1 xref: EMBL:BAA31602.1 xref: EMBL:BAB14995.1 xref: EMBL:CAB70852.1 xref: EMBL:CAC35157.1 xref: EMBL:CAC35158.1 xref: UniProtKB:O75122 xref: UniProtKB:Q7L8F6 xref: UniProtKB:Q8N6R6 xref: UniProtKB:Q9BQT3 xref: UniProtKB:Q9BQT4 xref: UniProtKB:Q9H7A3 xref: UniProtKB:Q9NSZ2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004367 ! CLASP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011252 ! CLAP2_HUMAN-Phosphoserine326 relationship: transforms_into CCO:B0011253 ! CLAP2_HUMAN-Phosphoserine327 relationship: transforms_into CCO:B0011254 ! CLAP2_HUMAN-Phosphoserine330 relationship: transforms_into CCO:B0011255 ! CLAP2_HUMAN-Phosphoserine507 relationship: transforms_into CCO:B0011256 ! CLAP2_HUMAN-Phosphoserine525 relationship: transforms_into CCO:B0011257 ! CLAP2_HUMAN-Phosphoserine529 relationship: transforms_into CCO:B0011258 ! CLAP2_HUMAN-Phosphoserine596 relationship: transforms_into CCO:B0011259 ! CLAP2_HUMAN-Phosphoserine994 relationship: transforms_into CCO:B0035993 ! CLAP2_HUMAN-Phosphoserine523 [Term] id: CCO:B0001424 name: GA45B_HUMAN def: "Growth arrest and DNA-damage-inducible protein GADD45 beta" [UniProtKB:O75293] synonym: "Myeloid differentiation primary response protein MyD118" EXACT [UniProtKB:O75293] synonym: "Negative growth regulatory protein MyD118" EXACT [UniProtKB:O75293] xref: EMBL:AAC34572.1 xref: EMBL:AAC36361.1 xref: EMBL:AAC83328.1 xref: EMBL:AAG48366.1 xref: EMBL:AAI13467.1 xref: EMBL:AAI17470.1 xref: EMBL:AAM92794.1 xref: UniProtKB:O75293 xref: UniProtKB:O75960 xref: UniProtKB:Q17R46 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004675 ! GADD45B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007531 ! map3k4-gadd45-2 physical interaction [Term] id: CCO:B0001425 name: TACC1_HUMAN def: "Transforming acidic coiled-coil-containing protein 1" [UniProtKB:O75410] synonym: "Gastric cancer antigen Ga55" EXACT [UniProtKB:O75410] synonym: "Taxin 1" EXACT [UniProtKB:O75410] xref: EMBL:AAC32327.1 xref: EMBL:AAH41391.1 xref: EMBL:AAK68658.1 xref: EMBL:AAL62461.1 xref: EMBL:AAL62462.1 xref: EMBL:AAL62463.2 xref: EMBL:AAN28955.1 xref: EMBL:AAO53446.1 xref: EMBL:BAA83055.1 xref: UniProtKB:O75410 xref: UniProtKB:Q6Y687 xref: UniProtKB:Q86YG7 xref: UniProtKB:Q8IUJ2 xref: UniProtKB:Q8IUJ3 xref: UniProtKB:Q8IUJ4 xref: UniProtKB:Q8IZG2 xref: UniProtKB:Q8NEY7 xref: UniProtKB:Q9UPP9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005721 ! TACC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006314 ! tacc1-lsm7-2 physical interaction relationship: participates_in CCO:I0006315 ! tacc1-snrpg-2 physical interaction relationship: participates_in CCO:I0006316 ! tacc1-tdrd7-6 physical interaction relationship: participates_in CCO:I0006317 ! tacc1-chtog-8 colocalization relationship: participates_in CCO:I0006969 ! tacc1-tdrd7-8 physical interaction relationship: participates_in CCO:I0007025 ! tacc1-yeats4-1 physical interaction relationship: participates_in CCO:I0007026 ! tacc1-yeats4-2 physical interaction relationship: participates_in CCO:I0007172 ! tacc1-yeats4-4 colocalization relationship: participates_in CCO:I0007314 ! tacc1-ckap5 physical interaction relationship: participates_in CCO:I0007315 ! tacc1-yeats4 physical interaction relationship: participates_in CCO:I0007353 ! tacc1-aurkb-5 physical interaction relationship: participates_in CCO:I0007354 ! tacc1-tdrd7-1 physical interaction relationship: participates_in CCO:I0007423 ! tacc1-aurkb-4 physical interaction relationship: participates_in CCO:I0007507 ! yeats4-tacc1 physical interaction relationship: participates_in CCO:I0007508 ! tacc1-yeats4-3 colocalization relationship: participates_in CCO:I0007566 ! tacc1-chtog-6 direct interaction relationship: participates_in CCO:I0007567 ! tacc1-tdrd7-7 physical interaction relationship: participates_in CCO:I0007871 ! tacc1-chtog-7 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014293 ! TACC1_HUMAN-Phosphoserine44 relationship: transforms_into CCO:B0014294 ! TACC1_HUMAN-Phosphoserine50 relationship: transforms_into CCO:B0014295 ! TACC1_HUMAN-Phosphoserine52 relationship: transforms_into CCO:B0014296 ! TACC1_HUMAN-Phosphoserine54 relationship: transforms_into CCO:B0014297 ! TACC1_HUMAN-Phosphoserine55 relationship: transforms_into CCO:B0014298 ! TACC1_HUMAN-Phosphoserine57 relationship: transforms_into CCO:B0014299 ! TACC1_HUMAN-Phosphotyrosine533 [Term] id: CCO:B0001426 name: CC45L_HUMAN def: "CDC45-related protein" [UniProtKB:O75419] synonym: "Cdc45" EXACT [UniProtKB:O75419] synonym: "PORC-PI-1" EXACT [UniProtKB:O75419] xref: EMBL:AAC27289.1 xref: EMBL:AAC67521.1 xref: EMBL:AAD08998.1 xref: EMBL:AAH06232.1 xref: EMBL:AAH10022.1 xref: EMBL:AAP35438.1 xref: EMBL:AAQ89330.1 xref: EMBL:AAS66985.1 xref: EMBL:CAA11530.1 xref: UniProtKB:O60856 xref: UniProtKB:O75419 xref: UniProtKB:Q6UW54 xref: UniProtKB:Q9UP68 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004235 ! CDC45L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006088 ! orc5l-cdc45l direct interaction relationship: participates_in CCO:I0006135 ! cdkn1a-cdc45l direct interaction relationship: participates_in CCO:I0006139 ! cdkn2a-cdc45l direct interaction relationship: participates_in CCO:P0000007 ! DNA replication checkpoint relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001427 name: KTNA1_HUMAN def: "Katanin p60 ATPase-containing subunit A1" [UniProtKB:O75449] synonym: "EC 3.6.4.3" EXACT [UniProtKB:O75449] synonym: "Katanin p60 subunit A1" EXACT [UniProtKB:O75449] synonym: "p60 katanin" EXACT [UniProtKB:O75449] xref: EMBL:AAC25114.1 xref: EMBL:AAH50428.1 xref: EMBL:CAI16431.1 xref: EMBL:CAI16432.1 xref: EMBL:CAI19504.1 xref: EMBL:CAI19505.1 xref: UniProtKB:O75449 xref: UniProtKB:Q5TFA8 xref: UniProtKB:Q5TFA9 xref: UniProtKB:Q86VN2 xref: UniProtKB:Q9NU52 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004963 ! KATNA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000324 ! interphase of mitotic cell cycle [Term] id: CCO:B0001428 name: ERN1_HUMAN def: "Serine/threonine-protein kinase/endoribonuclease IRE1 precursor" [UniProtKB:O75460] synonym: "Endoplasmic reticulum-to-nucleus signaling 1" EXACT [UniProtKB:O75460] synonym: "hIRE1p" EXACT [UniProtKB:O75460] synonym: "Inositol-requiring protein 1" EXACT [UniProtKB:O75460] synonym: "Ire1-alpha" EXACT [UniProtKB:O75460] synonym: "IRE1a" EXACT [UniProtKB:O75460] xref: EMBL:AAC25991.1 xref: UniProtKB:O75460 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004585 ! ERN1_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0000918 ! endoribonuclease activity relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000364 ! endoplasmic reticulum relationship: located_in CCO:C0000370 ! endoplasmic reticulum membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: located_in CCO:C0000990 ! integral to endoplasmic reticulum membrane relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001429 name: E2F6_HUMAN def: "Transcription factor E2F6" [UniProtKB:O75461] synonym: "E2F-6" EXACT [UniProtKB:O75461] xref: EMBL:AAC14694.1 xref: EMBL:AAC31426.1 xref: EMBL:AAH08348.1 xref: EMBL:AAI07741.1 xref: EMBL:AAM10783.1 xref: EMBL:AAM10784.1 xref: EMBL:AAM10785.1 xref: EMBL:AAY14826.1 xref: EMBL:CAD37950.1 xref: UniProtKB:O60544 xref: UniProtKB:O75461 xref: UniProtKB:Q53QY9 xref: UniProtKB:Q7Z2H6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004538 ! E2F6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005860 ! e2f6-tfdp1 physical interaction relationship: participates_in CCO:I0005947 ! e2f6-tfdp2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011621 ! E2F6_HUMAN-Phosphoserine67 [Term] id: CCO:B0001431 name: SUPT3_HUMAN def: "Transcription initiation protein SPT3 homolog" [UniProtKB:O75486] synonym: "SPT3-like protein" EXACT [UniProtKB:O75486] xref: EMBL:AAC36098.1 xref: EMBL:AAC39904.1 xref: EMBL:AAC70014.1 xref: UniProtKB:O75486 xref: UniProtKB:O76066 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005705 ! SUPT3H_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction [Term] id: CCO:B0001432 name: GEMI_HUMAN def: "Geminin" [UniProtKB:O75496] xref: EMBL:AAC39787.1 xref: EMBL:AAH05185.1 xref: EMBL:AAH05389.1 xref: EMBL:CAC21511.1 xref: UniProtKB:O75496 xref: UniProtKB:Q9H1Z1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004693 ! GMNN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006115 ! cdkn2a-gmnn direct interaction relationship: participates_in CCO:I0006121 ! mcm6-gmnn direct interaction relationship: participates_in CCO:I0006160 ! cdkn1a-gmnn direct interaction relationship: participates_in CCO:I0006854 ! cdt1-gmnn-5 physical interaction relationship: participates_in CCO:I0007405 ! cdt1-gmnn-2 physical interaction relationship: participates_in CCO:I0007406 ! cdt1-gmnn-3 physical interaction relationship: participates_in CCO:I0007957 ! cdt1-gmnn-4 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011928 ! GEMI_HUMAN-Phosphoserine64 [Term] id: CCO:B0001433 name: TAD3L_HUMAN def: "Transcriptional adapter 3-like" [UniProtKB:O75528] synonym: "ADA3 homolog" EXACT [UniProtKB:O75528] synonym: "ADA3-like protein" EXACT [UniProtKB:O75528] synonym: "hADA3" EXACT [UniProtKB:O75528] synonym: "STAF54" EXACT [UniProtKB:O75528] xref: EMBL:AAC39903.1 xref: EMBL:AAH09240.1 xref: EMBL:AAH13433.1 xref: EMBL:CAB55957.1 xref: UniProtKB:O75528 xref: UniProtKB:Q9UFS2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005723 ! TADA3L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction [Term] id: CCO:B0001434 name: RA51D_HUMAN def: "DNA repair protein RAD51 homolog 4" [UniProtKB:O75771] synonym: "R51H3" EXACT [UniProtKB:O75771] synonym: "RAD51-like protein 3" EXACT [UniProtKB:O75771] synonym: "TRAD" EXACT [UniProtKB:O75771] xref: EMBL:AAC39719.1 xref: EMBL:AAH14422.1 xref: EMBL:AAT38112.1 xref: EMBL:BAA25914.1 xref: EMBL:BAA31747.1 xref: EMBL:BAA31748.1 xref: EMBL:BAA31749.1 xref: EMBL:BAA33779.1 xref: EMBL:BAA33780.1 xref: EMBL:BAA33781.1 xref: EMBL:BAA33782.1 xref: EMBL:BAA34690.1 xref: EMBL:CAA75681.1 xref: EMBL:CAB55937.1 xref: UniProtKB:O43537 xref: UniProtKB:O60355 xref: UniProtKB:O75196 xref: UniProtKB:O75771 xref: UniProtKB:O75847 xref: UniProtKB:O75848 xref: UniProtKB:O76073 xref: UniProtKB:O76085 xref: UniProtKB:O94908 xref: UniProtKB:Q9UFU5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005407 ! RAD51L3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001435 name: CD123_HUMAN def: "Cell division cycle protein 123 homolog" [UniProtKB:O75794] synonym: "HT-1080" EXACT [UniProtKB:O75794] synonym: "Protein D123" EXACT [UniProtKB:O75794] synonym: "PZ32" EXACT [UniProtKB:O75794] xref: EMBL:AAC34738.1 xref: EMBL:AAH01600.1 xref: EMBL:AAH09598.1 xref: EMBL:BAA03593.1 xref: EMBL:CAG33247.1 xref: EMBL:CAI12495.1 xref: EMBL:CAI12496.1 xref: EMBL:CAI12497.1 xref: EMBL:CAI12498.1 xref: EMBL:CAI12499.1 xref: EMBL:CAI12500.1 xref: UniProtKB:O75794 xref: UniProtKB:Q14107 xref: UniProtKB:Q5T0L4 xref: UniProtKB:Q5T0L5 xref: UniProtKB:Q5T0L7 xref: UniProtKB:Q5T0L8 xref: UniProtKB:Q5T0L9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004268 ! CDC123_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000138 ! regulation of mitotic cell cycle [Term] id: CCO:B0001436 name: PR15A_HUMAN def: "Protein phosphatase 1 regulatory subunit 15A" [UniProtKB:O75807] synonym: "Growth arrest and DNA damage-inducible protein GADD34" EXACT [UniProtKB:O75807] synonym: "Myeloid differentiation primary response protein MyD116 homolog" EXACT [UniProtKB:O75807] xref: EMBL:AAC25631.1 xref: EMBL:AAH03067.1 xref: EMBL:BAA91649.1 xref: EMBL:CAG33540.1 xref: EMBL:EAW52409.1 xref: UniProtKB:O75807 xref: UniProtKB:Q6IA96 xref: UniProtKB:Q9NVU6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005984 ! PPP1R15A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008200 ! bcar1-ppp1r15a physical interaction relationship: participates_in CCO:I0008490 ! pou3f3-ppp1r15a physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0036022 ! PR15A_HUMAN-Phosphotyrosine262 relationship: transforms_into CCO:B0036023 ! PR15A_HUMAN-Phosphoserine264 [Term] id: CCO:B0001437 name: BCAR3_HUMAN def: "Breast cancer anti-estrogen resistance protein 3" [UniProtKB:O75815] synonym: "Novel SH2-containing protein 2" EXACT [UniProtKB:O75815] synonym: "SH2 domain-containing protein 3B" EXACT [UniProtKB:O75815] xref: EMBL:AAC39777.1 xref: EMBL:AAD28245.1 xref: EMBL:AAH39895.1 xref: EMBL:AAQ89355.1 xref: EMBL:CAH73975.1 xref: EMBL:CAI18950.1 xref: UniProtKB:O75815 xref: UniProtKB:Q6UW40 xref: UniProtKB:Q9BR50 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004147 ! BCAR3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0010764 ! BCAR3_HUMAN-Phosphothreonine130 relationship: transforms_into CCO:B0010765 ! BCAR3_HUMAN-Phosphoserine182 relationship: transforms_into CCO:B0010766 ! BCAR3_HUMAN-Phosphoserine290 relationship: transforms_into CCO:B0010767 ! BCAR3_HUMAN-Phosphoserine370 relationship: transforms_into CCO:B0010768 ! BCAR3_HUMAN-Phosphoserine375 [Term] id: CCO:B0001438 name: TUSC2_HUMAN def: "Tumor suppressor candidate 2" [UniProtKB:O75896] synonym: "Fus-1 protein" EXACT [UniProtKB:O75896] synonym: "Fusion 1 protein" EXACT [UniProtKB:O75896] synonym: "PDGFA-associated protein 2" EXACT [UniProtKB:O75896] xref: EMBL:AAC35497.1 xref: EMBL:AAH23976.1 xref: UniProtKB:O75896 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005844 ! TUSC2_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0014556 ! TUSC2_HUMAN-Phosphoserine50 [Term] id: CCO:B0001439 name: CCNK_HUMAN def: "Cyclin-K" [UniProtKB:O75909] xref: EMBL:AAD09978.1 xref: EMBL:AAF82290.1 xref: EMBL:AAH15935.1 xref: EMBL:AAN06829.1 xref: EMBL:AAP35596.1 xref: UniProtKB:O75909 xref: UniProtKB:Q96B63 xref: UniProtKB:Q9NNY9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004260 ! CCNK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005728 ! ccnk-tsc22d4 physical interaction relationship: participates_in CCO:I0005770 ! ccnk-ushbp1 physical interaction relationship: participates_in CCO:I0005775 ! ccnk-efemp2 physical interaction relationship: participates_in CCO:I0005777 ! ccnk-kcnrg physical interaction relationship: participates_in CCO:I0005781 ! ccnk-fkbp6 physical interaction relationship: participates_in CCO:I0005782 ! ccnk-stx11 physical interaction relationship: participates_in CCO:I0005784 ! ccnk-rfxdc1 physical interaction relationship: participates_in CCO:I0005798 ! ccnk-rbpms physical interaction relationship: participates_in CCO:I0005820 ! ccnk-cep76 physical interaction relationship: participates_in CCO:I0005884 ! ccnk-pepp2 physical interaction relationship: participates_in CCO:I0005900 ! ccnk-krtap4_12 physical interaction relationship: participates_in CCO:I0005904 ! ccnk-pctk3 physical interaction relationship: participates_in CCO:I0005910 ! ccnk-hmg20a physical interaction relationship: participates_in CCO:I0006215 ! atxn1-ccnk physical interaction relationship: participates_in CCO:I0006645 ! ccnk-atxn1 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011001 ! CCNK_HUMAN-Phosphoserine324 relationship: transforms_into CCO:B0011002 ! CCNK_HUMAN-Phosphoserine329 relationship: transforms_into CCO:B0011003 ! CCNK_HUMAN-Phosphoserine340 [Term] id: CCO:B0001440 name: DCTN3_HUMAN def: "Dynactin subunit 3" [UniProtKB:O75935] synonym: "Dynactin complex subunit 22 kDa subunit" EXACT [UniProtKB:O75935] synonym: "p22" EXACT [UniProtKB:O75935] xref: EMBL:AAC61280.1 xref: EMBL:AAH00319.1 xref: EMBL:AAH03004.1 xref: EMBL:AAI07698.1 xref: EMBL:CAG46687.1 xref: EMBL:CAI13143.1 xref: EMBL:CAI13144.1 xref: EMBL:CAI13145.1 xref: EMBL:CAI14178.1 xref: EMBL:CAI14180.1 xref: EMBL:CAI14181.1 xref: EMBL:CAI14182.1 xref: UniProtKB:O75935 xref: UniProtKB:Q5T1I5 xref: UniProtKB:Q5T1I7 xref: UniProtKB:Q5T8G3 xref: UniProtKB:Q9BPU8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004449 ! DCTN3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007333 ! pbx2-p22 physical interaction relationship: participates_in CCO:I0007624 ! atxn1-dctn3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001441 name: RAD17_HUMAN def: "Cell cycle checkpoint protein RAD17" [UniProtKB:O75943] synonym: "hRad17" EXACT [UniProtKB:O75943] synonym: "RF-C/activator 1 homolog" EXACT [UniProtKB:O75943] xref: EMBL:AAC36334.1 xref: EMBL:AAC95520.1 xref: EMBL:AAC97950.1 xref: EMBL:AAC97951.1 xref: EMBL:AAD01620.1 xref: EMBL:AAD17334.1 xref: EMBL:AAD38878.1 xref: EMBL:AAH32304.1 xref: EMBL:AAT09763.1 xref: EMBL:CAA04894.1 xref: EMBL:CAA06251.1 xref: EMBL:CAB46364.1 xref: EMBL:CAB59244.1 xref: EMBL:CAD97683.1 xref: UniProtKB:O75714 xref: UniProtKB:O75943 xref: UniProtKB:Q7Z3S4 xref: UniProtKB:Q9UNK7 xref: UniProtKB:Q9UNR7 xref: UniProtKB:Q9UNR8 xref: UniProtKB:Q9UPF5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005412 ! RAD17_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006664 ! npm_alk-gak physical interaction relationship: participates_in CCO:P0000007 ! DNA replication checkpoint relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint relationship: transforms_into CCO:B0013661 ! RAD17_HUMAN-Phosphothreonine55 relationship: transforms_into CCO:B0013662 ! RAD17_HUMAN-Phosphothreonine304 relationship: transforms_into CCO:B0013663 ! RAD17_HUMAN-Phosphoserine646 relationship: transforms_into CCO:B0013664 ! RAD17_HUMAN-Phosphoserine656 [Term] id: CCO:B0001443 name: BPAEA_HUMAN def: "Bullous pemphigoid antigen 1, isoforms 6/9/10" [UniProtKB:O94833] synonym: "BPA" EXACT [UniProtKB:O94833] synonym: "Bullous pemphigoid antigen" EXACT [UniProtKB:O94833] synonym: "Dystonia musculorum protein" EXACT [UniProtKB:O94833] synonym: "Dystonin" EXACT [UniProtKB:O94833] synonym: "Hemidesmosomal plaque protein" EXACT [UniProtKB:O94833] synonym: "Trabeculin-beta" EXACT [UniProtKB:O94833] xref: EMBL:AAH16991.1 xref: EMBL:AAL62061.1 xref: EMBL:BAA34448.2 xref: EMBL:BAB70870.1 xref: EMBL:BAC04449.1 xref: EMBL:BAC04848.1 xref: EMBL:CAI16610.1 xref: EMBL:CAI20332.1 xref: EMBL:CAI22045.1 xref: UniProtKB:O94833 xref: UniProtKB:Q5TBT0 xref: UniProtKB:Q8N1T8 xref: UniProtKB:Q8N8J3 xref: UniProtKB:Q8WXK9 xref: UniProtKB:Q96AK9 xref: UniProtKB:Q96DQ5 xref: UniProtKB:Q9H555 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004183 ! DST_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006473 ! celsr3-bpag1 physical interaction relationship: participates_in CCO:I0006476 ! kiaa1549-bpag1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0010826 ! BPAEA_HUMAN-Phosphoserine1558 relationship: transforms_into CCO:B0010827 ! BPAEA_HUMAN-Phosphoserine5111 relationship: transforms_into CCO:B0010828 ! BPAEA_HUMAN-Phosphoserine5114 relationship: transforms_into CCO:B0010829 ! BPAEA_HUMAN-Phosphoserine5163 relationship: transforms_into CCO:B0035986 ! BPAEA_HUMAN-Phosphothreonine4352 [Term] id: CCO:B0001444 name: SASH1_HUMAN def: "SAM and SH3 domain-containing protein 1" [UniProtKB:O94885] synonym: "Proline-glutamate repeat-containing protein" EXACT [UniProtKB:O94885] xref: EMBL:AAH28303.1 xref: EMBL:AAQ55463.1 xref: EMBL:BAA34510.1 xref: EMBL:BAB14909.1 xref: EMBL:CAD47811.1 xref: EMBL:CAD92036.1 xref: UniProtKB:O94885 xref: UniProtKB:Q8TAI0 xref: UniProtKB:Q9H7R7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005565 ! SASH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013961 ! SASH1_HUMAN-Phosphoserine90 relationship: transforms_into CCO:B0013962 ! SASH1_HUMAN-Phosphoserine731 relationship: transforms_into CCO:B0013963 ! SASH1_HUMAN-Phosphoserine821 relationship: transforms_into CCO:B0013964 ! SASH1_HUMAN-Phosphoserine839 [Term] id: CCO:B0001445 name: HEXI1_HUMAN def: "Protein HEXIM1" [UniProtKB:O94992] synonym: "Cardiac lineage protein 1" EXACT [UniProtKB:O94992] synonym: "Estrogen down-regulated gene 1 protein" EXACT [UniProtKB:O94992] synonym: "Hexamethylene bis-acetamide-inducible protein 1" EXACT [UniProtKB:O94992] synonym: "Menage a quatre protein 1" EXACT [UniProtKB:O94992] xref: EMBL:AAH06460.1 xref: EMBL:BAA36166.1 xref: UniProtKB:O94992 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004801 ! HEXIM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity relationship: transforms_into CCO:B0012180 ! HEXI1_HUMAN-Phosphoserine97 relationship: transforms_into CCO:B0012181 ! HEXI1_HUMAN-Phosphoserine98 [Term] id: CCO:B0001446 name: CCNB2_HUMAN def: "G2/mitotic-specific cyclin-B2" [UniProtKB:O95067] xref: EMBL:AAD09309.1 xref: EMBL:AAI05087.1 xref: EMBL:AAI05113.1 xref: EMBL:AAW34361.1 xref: EMBL:BAA78387.1 xref: EMBL:CAB45739.1 xref: EMBL:CAG38558.1 xref: UniProtKB:O95067 xref: UniProtKB:Q6FI99 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004245 ! CCNB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006102 ! mcm2-ccnb2 direct interaction relationship: participates_in CCO:I0006149 ! cdkn1a-ccnb2 direct interaction relationship: participates_in CCO:I0006155 ! cdk2-ccnb2 direct interaction relationship: participates_in CCO:I0007900 ! cyclinb2_cdk1_human direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001447 name: REC8_HUMAN def: "Meiotic recombination protein REC8 homolog" [UniProtKB:O95072] synonym: "Cohesin Rec8p" EXACT [UniProtKB:O95072] xref: EMBL:AAD01193.1 xref: EMBL:AAH04159.1 xref: EMBL:AAH10887.1 xref: EMBL:AAH19326.1 xref: EMBL:BAA91690.1 xref: EMBL:CAG33544.1 xref: UniProtKB:O95072 xref: UniProtKB:Q6IA92 xref: UniProtKB:Q8WUV8 xref: UniProtKB:Q9BTF2 xref: UniProtKB:Q9NVQ9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005459 ! REC8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000076 ! sister chromatid cohesion relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001449 name: ZWINT_HUMAN def: "ZW10 interactor" [UniProtKB:O95229] synonym: "ZW10-interacting protein 1" EXACT [UniProtKB:O95229] synonym: "Zwint-1" EXACT [UniProtKB:O95229] xref: EMBL:AAC78629.1 xref: EMBL:AAH00411.1 xref: EMBL:AAH20979.1 xref: EMBL:AAI10400.1 xref: UniProtKB:O95229 xref: UniProtKB:Q0D2I3 xref: UniProtKB:Q9BWD0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005975 ! ZWINT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006066 ! kntc2_zwint_5 physical interaction relationship: participates_in CCO:I0006446 ! kntc2_zwint_6 colocalization relationship: participates_in CCO:I0006447 ! zw10_zwint_2 colocalization relationship: participates_in CCO:I0006448 ! zwint_mad2l1_1 colocalization relationship: participates_in CCO:I0006449 ! zwint_bub1b_1 colocalization relationship: participates_in CCO:I0006750 ! zwint_zw10_2 colocalization relationship: participates_in CCO:I0006755 ! kntc2_zwint_4 colocalization relationship: participates_in CCO:I0006756 ! zw10_zwint_1 colocalization relationship: participates_in CCO:I0006791 ! kntc2_zwint_1 physical interaction relationship: participates_in CCO:I0007157 ! kntc2_zwint_2 physical interaction relationship: participates_in CCO:I0007158 ! zwint_kntc2_2 physical interaction relationship: participates_in CCO:I0007159 ! kntc2_zwint_3 physical interaction relationship: participates_in CCO:I0007160 ! zw10_kntc2_1 physical interaction relationship: participates_in CCO:I0007161 ! zwint_kntc2_3 physical interaction relationship: participates_in CCO:I0007162 ! zw10_kntc2_2 physical interaction relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction relationship: participates_in CCO:I0007820 ! zwint_zw10_1 physical interaction relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint [Term] id: CCO:B0001450 name: SMC2_HUMAN def: "Structural maintenance of chromosomes protein 2" [UniProtKB:O95347] synonym: "Chromosome-associated protein E" EXACT [UniProtKB:O95347] synonym: "hCAP-E" EXACT [UniProtKB:O95347] synonym: "XCAP-E homolog" EXACT [UniProtKB:O95347] xref: EMBL:AAC72360.1 xref: EMBL:AAF29579.1 xref: UniProtKB:O95347 xref: UniProtKB:Q9P1P2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005627 ! SMC2_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0006299 ! protein heterodimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000040 ! nuclear chromosome relationship: located_in CCO:C0000120 ! condensed chromosome relationship: located_in CCO:C0000123 ! condensin complex relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000296 ! chromosome relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0006360 ! ikbkg-smc2l1 physical interaction relationship: participates_in CCO:I0006602 ! disc1-smc2l1 physical interaction relationship: participates_in CCO:I0006930 ! smc2-hp1 colocalization relationship: participates_in CCO:I0007038 ! smc2l1-smc4l1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation [Term] id: CCO:B0001451 name: YETS4_HUMAN def: "YEATS domain-containing protein 4" [UniProtKB:O95619] synonym: "Gas41" EXACT [UniProtKB:O95619] synonym: "Glioma-amplified sequence 41" EXACT [UniProtKB:O95619] synonym: "NuBI-1" EXACT [UniProtKB:O95619] synonym: "NuBI1" EXACT [UniProtKB:O95619] synonym: "NuMA-binding protein 1" EXACT [UniProtKB:O95619] xref: EMBL:AAD12188.1 xref: EMBL:AAH00994.1 xref: EMBL:BAA91678.1 xref: EMBL:CAC01935.1 xref: UniProtKB:O95619 xref: UniProtKB:Q9NQD0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005950 ! YEATS4_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001486 ! structural constituent of cytoskeleton relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000785 ! nuclear matrix relationship: participates_in CCO:I0006035 ! mrgbp-ruvbl1-1 physical interaction relationship: participates_in CCO:I0006036 ! tclf1-ruvbl1-2 physical interaction relationship: participates_in CCO:I0006037 ! znf-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006038 ! tclf1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0006042 ! tclf1-ruvbl1-7 physical interaction relationship: participates_in CCO:I0007025 ! tacc1-yeats4-1 physical interaction relationship: participates_in CCO:I0007026 ! tacc1-yeats4-2 physical interaction relationship: participates_in CCO:I0007072 ! c20orf20-epc1-2 physical interaction relationship: participates_in CCO:I0007172 ! tacc1-yeats4-4 colocalization relationship: participates_in CCO:I0007315 ! tacc1-yeats4 physical interaction relationship: participates_in CCO:I0007507 ! yeats4-tacc1 physical interaction relationship: participates_in CCO:I0007508 ! tacc1-yeats4-3 colocalization relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: participates_in CCO:I0007771 ! ruvbl2-ruvbl1 physical interaction relationship: participates_in CCO:I0007772 ! mrgbp-ruvbl1 physical interaction relationship: participates_in CCO:I0007773 ! znf-ruvbl physical interaction relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001452 name: O95648_HUMAN def: "Septin" [UniProtKB:O95648] xref: EMBL:AAD00564.1 xref: UniProtKB:O95648 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001453 name: DIRA3_HUMAN def: "GTP-binding protein Di-Ras3" [UniProtKB:O95661] synonym: "Distinct subgroup of the Ras family member 3" EXACT [UniProtKB:O95661] synonym: "Rho-related GTP-binding protein RhoI" EXACT [UniProtKB:O95661] xref: EMBL:AAD03164.1 xref: EMBL:AAG35625.1 xref: EMBL:AAH05362.1 xref: EMBL:CAG46668.1 xref: EMBL:CAG46690.1 xref: EMBL:CAI21991.1 xref: UniProtKB:O95661 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004473 ! DIRAS3_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000427 ! GTPase activity relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity [Term] id: CCO:B0001454 name: LATS1_HUMAN def: "Serine/threonine-protein kinase LATS1" [UniProtKB:O95835] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O95835] synonym: "h-warts" EXACT [UniProtKB:O95835] synonym: "Large tumor suppressor homolog 1" EXACT [UniProtKB:O95835] synonym: "WARTS protein kinase" EXACT [UniProtKB:O95835] xref: EMBL:AAD16882.1 xref: EMBL:AAD50272.1 xref: EMBL:AAH02767.1 xref: UniProtKB:O95835 xref: UniProtKB:Q6PKD0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004971 ! LATS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006610 ! lats1-limk1-3 physical interaction relationship: participates_in CCO:I0006849 ! lats1-cdc2-1 physical interaction relationship: participates_in CCO:I0006850 ! lats1-limk1-1 physical interaction relationship: participates_in CCO:I0006851 ! lats1-limk1-2 physical interaction relationship: participates_in CCO:I0006954 ! lats1-zyx-1 physical interaction relationship: participates_in CCO:I0007236 ! lats1-zyx-6 colocalization relationship: participates_in CCO:I0007237 ! lats1-limk1-5 colocalization relationship: participates_in CCO:I0007728 ! lats1-zyx-4 physical interaction relationship: participates_in CCO:I0007729 ! lats1-cdc2-2 physical interaction relationship: participates_in CCO:I0007730 ! lats1-limk1-4 physical interaction relationship: participates_in CCO:I0007950 ! lats1-zyx-2 physical interaction relationship: participates_in CCO:I0007951 ! lats1-zyx-3 physical interaction relationship: participates_in CCO:I0007952 ! lats1-zyx-5 physical interaction relationship: participates_in CCO:I0007953 ! lats1-zyx-7 physical interaction relationship: participates_in CCO:I0007958 ! lats1-zyx-8 physical interaction relationship: participates_in CCO:I0007959 ! lats1-zyx-9 physical interaction relationship: participates_in CCO:I0007960 ! lats1-zyx-10 physical interaction relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: participates_in CCO:P0000054 ! sister chromatid segregation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0012677 ! LATS1_HUMAN-Phosphoserine244 relationship: transforms_into CCO:B0012678 ! LATS1_HUMAN-Phosphoserine464 relationship: transforms_into CCO:B0012679 ! LATS1_HUMAN-Phosphoserine674 relationship: transforms_into CCO:B0012680 ! LATS1_HUMAN-Phosphoserine909 relationship: transforms_into CCO:B0012681 ! LATS1_HUMAN-Phosphothreonine1079 [Term] id: CCO:B0001455 name: RECK_HUMAN def: "Reversion-inducing cysteine-rich protein with Kazal motifs precursor" [UniProtKB:O95980] synonym: "hRECK" EXACT [UniProtKB:O95980] synonym: "ST15" EXACT [UniProtKB:O95980] synonym: "Suppressor of tumorigenicity 15" EXACT [UniProtKB:O95980] xref: EMBL:BAA34060.1 xref: EMBL:CAD13384.2 xref: EMBL:CAH70155.1 xref: UniProtKB:O95980 xref: UniProtKB:Q5W0K6 xref: UniProtKB:Q8WX37 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005460 ! RECK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001457 name: PTTG1_HUMAN def: "Securin" [UniProtKB:O95997] synonym: "Esp1-associated protein" EXACT [UniProtKB:O95997] synonym: "hPTTG" EXACT [UniProtKB:O95997] synonym: "Pituitary tumor-transforming protein 1" EXACT [UniProtKB:O95997] synonym: "Tumor-transforming protein 1" EXACT [UniProtKB:O95997] xref: EMBL:AAC64409.1 xref: EMBL:AAD19335.1 xref: EMBL:AAF06995.1 xref: EMBL:CAA11683.1 xref: UniProtKB:O95997 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005403 ! PTTG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013650 ! PTTG1_HUMAN-Phosphoserine165 [Term] id: CCO:B0001458 name: BCL10_HUMAN def: "B-cell lymphoma/leukemia 10" [UniProtKB:O95999] synonym: "B-cell CLL/lymphoma 10" EXACT [UniProtKB:O95999] synonym: "Bcl-10" EXACT [UniProtKB:O95999] synonym: "c-E10" EXACT [UniProtKB:O95999] synonym: "CARD-containing molecule enhancing NF-kappa-B" EXACT [UniProtKB:O95999] synonym: "CARD-like apoptotic protein" EXACT [UniProtKB:O95999] synonym: "cCARMEN" EXACT [UniProtKB:O95999] synonym: "CED-3/ICH-1 prodomain homologous E10-like regulator" EXACT [UniProtKB:O95999] synonym: "Cellular homolog of vCARMEN" EXACT [UniProtKB:O95999] synonym: "Cellular-E10" EXACT [UniProtKB:O95999] synonym: "CIPER" EXACT [UniProtKB:O95999] synonym: "hCLAP" EXACT [UniProtKB:O95999] synonym: "Mammalian CARD-containing adapter molecule E10" EXACT [UniProtKB:O95999] synonym: "mE10" EXACT [UniProtKB:O95999] xref: EMBL:AAC99767.1 xref: EMBL:AAD15800.1 xref: EMBL:AAD16428.1 xref: EMBL:AAD24918.1 xref: EMBL:AAD32597.1 xref: EMBL:AAD39147.1 xref: EMBL:AAF06894.1 xref: EMBL:AAH53617.1 xref: EMBL:CAA06955.1 xref: UniProtKB:O95999 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004150 ! BCL10_human relationship: has_function CCO:F0000300 ! transcription coactivator activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0001738 ! transcription factor binding relationship: has_function CCO:F0004132 ! kinase activator activity relationship: has_function CCO:F0004209 ! kinase binding relationship: has_function CCO:F0004210 ! protein kinase binding relationship: has_function CCO:F0004689 ! ubiquitin protein ligase binding relationship: has_function CCO:F0005797 ! ubiquitin binding relationship: has_function CCO:F0005850 ! protein kinase B binding relationship: has_function CCO:F0005879 ! protein self-association relationship: has_function CCO:F0008045 ! NF-kappaB binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000347 ! lysosome relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001453 ! CBM complex relationship: located_in CCO:C0001630 ! T cell receptor complex relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0001962 ! lipopolysaccharide receptor complex relationship: located_in CCO:C0001996 ! perinuclear region of cytoplasm relationship: participates_in CCO:I0006342 ! bcl10-akt1-3 physical interaction relationship: participates_in CCO:I0006343 ! bcl10-bcl3-3 physical interaction relationship: participates_in CCO:I0007374 ! bcl10-akt1-4 physical interaction relationship: participates_in CCO:I0007795 ! bcl10-akt1-1 physical interaction relationship: participates_in CCO:I0007796 ! bcl10-akt1-2 physical interaction relationship: participates_in CCO:I0007797 ! bcl10-bcl3-1 physical interaction relationship: participates_in CCO:I0007798 ! bcl10-bcl3-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001459 name: CHK2_HUMAN def: "Serine/threonine-protein kinase Chk2" [UniProtKB:O96017] synonym: "Cds1" EXACT [UniProtKB:O96017] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O96017] xref: EMBL:AAC83693.1 xref: EMBL:AAD11784.1 xref: EMBL:AAD48504.1 xref: EMBL:AAH04207.1 xref: EMBL:AAS58456.1 xref: EMBL:AAS58457.1 xref: EMBL:AAS58458.1 xref: EMBL:AAS58459.1 xref: EMBL:AAS58460.1 xref: EMBL:AAS58461.1 xref: EMBL:AAS58462.1 xref: EMBL:AAS58463.1 xref: EMBL:AAS58464.1 xref: EMBL:AAS58465.1 xref: EMBL:AAS58466.1 xref: EMBL:AAV41895.1 xref: EMBL:BAB17231.1 xref: EMBL:CAA10319.1 xref: EMBL:CAG30304.1 xref: EMBL:CAH73823.1 xref: EMBL:CAH73875.1 xref: UniProtKB:O96017 xref: UniProtKB:Q6QA03 xref: UniProtKB:Q6QA04 xref: UniProtKB:Q6QA05 xref: UniProtKB:Q6QA06 xref: UniProtKB:Q6QA07 xref: UniProtKB:Q6QA08 xref: UniProtKB:Q6QA10 xref: UniProtKB:Q6QA11 xref: UniProtKB:Q6QA12 xref: UniProtKB:Q6QA13 xref: UniProtKB:Q9HCQ8 xref: UniProtKB:Q9UGF0 xref: UniProtKB:Q9UGF1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004348 ! CHEK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006254 ! chek2-aatf-2 phosphorylation relationship: participates_in CCO:I0006257 ! chek2-aatf-3 phosphorylation relationship: participates_in CCO:I0007041 ! chek2-aatf physical interaction relationship: participates_in CCO:I0007178 ! chek2-aatf-1 physical interaction relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011217 ! CHK2_HUMAN-Phosphothreonine68 [Term] id: CCO:B0001460 name: CCNE2_HUMAN def: "G1/S-specific cyclin-E2" [UniProtKB:O96020] xref: EMBL:AAC78145.1 xref: EMBL:AAC80528.1 xref: EMBL:AAD08816.1 xref: EMBL:AAD08819.1 xref: EMBL:AAV97813.1 xref: UniProtKB:O95439 xref: UniProtKB:O96020 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004252 ! CCNE2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006107 ! orc3l-ccne2 direct interaction relationship: participates_in CCO:I0006127 ! cdk2-ccne2 direct interaction relationship: participates_in CCO:I0006132 ! cdkn1a-ccne2 direct interaction relationship: participates_in CCO:I0007908 ! cycline2_cdk2_human direct interaction relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0010997 ! CCNE2_HUMAN-Phosphothreonine392 [Term] id: CCO:B0001461 name: ABL1_HUMAN def: "Proto-oncogene tyrosine-protein kinase ABL1" [UniProtKB:P00519] synonym: "Abelson murine leukemia viral oncogene homolog 1" EXACT [UniProtKB:P00519] synonym: "c-ABL" EXACT [UniProtKB:P00519] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P00519] synonym: "p150" EXACT [UniProtKB:P00519] xref: EMBL:AAA51561.1 xref: EMBL:AAB60393.1 xref: EMBL:AAB60394.1 xref: EMBL:AAD14034.1 xref: EMBL:AAZ38718.1 xref: EMBL:CAA34438.1 xref: UniProtKB:P00519 xref: UniProtKB:Q13869 xref: UniProtKB:Q13870 xref: UniProtKB:Q16133 xref: UniProtKB:Q45F09 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004013 ! ABL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006071 ! abl1-rin1-3 physical interaction relationship: participates_in CCO:I0006203 ! abl1-ywhaz-1 physical interaction relationship: participates_in CCO:I0006204 ! abl1-snf-1 physical interaction relationship: participates_in CCO:I0006307 ! abl1-ywhab-1 physical interaction relationship: participates_in CCO:I0006728 ! abl1-sorbs-2 physical interaction relationship: participates_in CCO:I0006922 ! abl1-rin1-1 physical interaction relationship: participates_in CCO:I0006923 ! abl1-rin1-2 physical interaction relationship: participates_in CCO:I0006953 ! abi1-nckap1-1 physical interaction relationship: participates_in CCO:I0007069 ! abi1-abl1-2 physical interaction relationship: participates_in CCO:I0007171 ! abl1-rin1-4 phosphorylation relationship: participates_in CCO:I0007527 ! abi1-abl1-1 physical interaction relationship: participates_in CCO:I0007696 ! atm-cabl-1 physical interaction relationship: participates_in CCO:I0007751 ! abl1-sorbs-1 physical interaction relationship: participates_in CCO:I0007799 ! st5-abl1-1 physical interaction relationship: participates_in CCO:P0000025 ! S-phase-specific transcription in mitotic cell cycle relationship: transforms_into CCO:B0010398 ! ABL1_HUMAN-Phosphotyrosine185 relationship: transforms_into CCO:B0010399 ! ABL1_HUMAN-Phosphotyrosine226 relationship: transforms_into CCO:B0010400 ! ABL1_HUMAN-Phosphotyrosine253 relationship: transforms_into CCO:B0010401 ! ABL1_HUMAN-Phosphotyrosine257 relationship: transforms_into CCO:B0010402 ! ABL1_HUMAN-Phosphotyrosine264 relationship: transforms_into CCO:B0010403 ! ABL1_HUMAN-Phosphotyrosine393 relationship: transforms_into CCO:B0010404 ! ABL1_HUMAN-Phosphothreonine394 relationship: transforms_into CCO:B0010405 ! ABL1_HUMAN-Phosphoserine446 relationship: transforms_into CCO:B0010406 ! ABL1_HUMAN-Phosphotyrosine469 relationship: transforms_into CCO:B0010407 ! ABL1_HUMAN-Phosphoserine569 relationship: transforms_into CCO:B0010408 ! ABL1_HUMAN-Phosphoserine683 relationship: transforms_into CCO:B0010409 ! ABL1_HUMAN-Phosphoserine805 relationship: transforms_into CCO:B0010410 ! ABL1_HUMAN-Phosphoserine809 relationship: transforms_into CCO:B0010411 ! ABL1_HUMAN-Phosphoserine949 [Term] id: CCO:B0001462 name: EGFR_HUMAN def: "Epidermal growth factor receptor precursor" [UniProtKB:P00533] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P00533] synonym: "Receptor tyrosine-protein kinase ErbB-1" EXACT [UniProtKB:P00533] xref: EMBL:AAA52370.1 xref: EMBL:AAA63171.1 xref: EMBL:AAB53063.1 xref: EMBL:AAC50796.1 xref: EMBL:AAC50797.1 xref: EMBL:AAC50798.1 xref: EMBL:AAC50799.1 xref: EMBL:AAC50800.1 xref: EMBL:AAC50801.1 xref: EMBL:AAC50802.1 xref: EMBL:AAC50804.1 xref: EMBL:AAG35786.1 xref: EMBL:AAG35787.1 xref: EMBL:AAG35788.1 xref: EMBL:AAG35789.1 xref: EMBL:AAG35790.1 xref: EMBL:AAG43240.1 xref: EMBL:AAG43243.1 xref: EMBL:AAK01080.1 xref: EMBL:AAS83109.1 xref: EMBL:CAA25240.1 xref: EMBL:CAA25282.1 xref: EMBL:CAA29668.1 xref: UniProtKB:O00688 xref: UniProtKB:O00732 xref: UniProtKB:P00533 xref: UniProtKB:P06268 xref: UniProtKB:Q14225 xref: UniProtKB:Q92795 xref: UniProtKB:Q9BZS2 xref: UniProtKB:Q9GZX1 xref: UniProtKB:Q9H2C9 xref: UniProtKB:Q9H3C9 xref: UniProtKB:Q9UMD7 xref: UniProtKB:Q9UMD8 xref: UniProtKB:Q9UMG5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004552 ! EGFR_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005972 ! egf-egfr-2 direct interaction relationship: participates_in CCO:I0006214 ! rabgef1-egfr physical interaction relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0006278 ! egfr-grb2 physical interaction relationship: participates_in CCO:I0006282 ! ywhaz-egfr-1 physical interaction relationship: participates_in CCO:I0006444 ! erbb2-egfr physical interaction relationship: participates_in CCO:I0006445 ! erbb2-egfr-1 physical interaction relationship: participates_in CCO:I0006532 ! egf-egfr-1 direct interaction relationship: participates_in CCO:I0006677 ! grb2-egfr-1 physical interaction relationship: participates_in CCO:I0006842 ! egfr-grb2-1 physical interaction relationship: participates_in CCO:I0006978 ! egfr-pik3c2b-2 physical interaction relationship: participates_in CCO:I0006979 ! egfr-pik3c2b-5 physical interaction relationship: participates_in CCO:I0007122 ! egfr-cbl1-1 direct interaction relationship: participates_in CCO:I0007123 ! egfr-cbl1-4 direct interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007167 ! egfr-tgfa-1 direct interaction relationship: participates_in CCO:I0007197 ! egfr-h3fa-1 colocalization relationship: participates_in CCO:I0007198 ! egfr-cd59-1 direct interaction relationship: participates_in CCO:I0007304 ! erbb2-egfr-2 physical interaction relationship: participates_in CCO:I0007305 ! erbb2-egfr-3 physical interaction relationship: participates_in CCO:I0007365 ! erbb1-erbb3-2 physical interaction relationship: participates_in CCO:I0007366 ! erbb1-erbb4-2 physical interaction relationship: participates_in CCO:I0007428 ! egfr-pik3c2b-3 direct interaction relationship: participates_in CCO:I0007429 ! egfr-pik3c2b-6 direct interaction relationship: participates_in CCO:I0007453 ! gab2-grb2-1 physical interaction relationship: participates_in CCO:I0007503 ! egf-egfr-3 direct interaction relationship: participates_in CCO:I0007516 ! egfr-cav1-clca physical interaction relationship: participates_in CCO:I0007570 ! egfr-pik3c2b-4 physical interaction relationship: participates_in CCO:I0007591 ! erbb1-erbb2-1 physical interaction relationship: participates_in CCO:I0007592 ! erbb1-erbb3-1 physical interaction relationship: participates_in CCO:I0007593 ! erbb1-erbb4-1 physical interaction relationship: participates_in CCO:I0007817 ! erbb2-egfr-4 physical interaction relationship: participates_in CCO:I0007845 ! ywhaz-egfr-2 colocalization relationship: participates_in CCO:I0007877 ! egfr-pik3c2a-1 physical interaction relationship: participates_in CCO:I0007878 ! egfr-pik3c2b-1 physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: participates_in CCO:I0008360 ! atp5c1-egfr physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011651 ! EGFR_HUMAN-Phosphothreonine678 relationship: transforms_into CCO:B0011652 ! EGFR_HUMAN-Phosphothreonine693 relationship: transforms_into CCO:B0011653 ! EGFR_HUMAN-Phosphoserine695 relationship: transforms_into CCO:B0011654 ! EGFR_HUMAN-Phosphotyrosine978 relationship: transforms_into CCO:B0011655 ! EGFR_HUMAN-Phosphoserine991 relationship: transforms_into CCO:B0011656 ! EGFR_HUMAN-Phosphoserine995 relationship: transforms_into CCO:B0011657 ! EGFR_HUMAN-Phosphotyrosine998 relationship: transforms_into CCO:B0011658 ! EGFR_HUMAN-Phosphoserine1026 relationship: transforms_into CCO:B0011659 ! EGFR_HUMAN-Phosphoserine1064 relationship: transforms_into CCO:B0011660 ! EGFR_HUMAN-Phosphotyrosine1069 relationship: transforms_into CCO:B0011661 ! EGFR_HUMAN-Phosphoserine1070 relationship: transforms_into CCO:B0011662 ! EGFR_HUMAN-Phosphoserine1071 relationship: transforms_into CCO:B0011663 ! EGFR_HUMAN-Phosphotyrosine1092 relationship: transforms_into CCO:B0011664 ! EGFR_HUMAN-Phosphotyrosine1110 relationship: transforms_into CCO:B0011665 ! EGFR_HUMAN-Phosphotyrosine1138 relationship: transforms_into CCO:B0011666 ! EGFR_HUMAN-Phosphoserine1166 relationship: transforms_into CCO:B0011667 ! EGFR_HUMAN-Phosphotyrosine1172 relationship: transforms_into CCO:B0011668 ! EGFR_HUMAN-Phosphotyrosine1197 [Term] id: CCO:B0001465 name: MYC_HUMAN def: "Myc proto-oncogene protein" [UniProtKB:P01106] synonym: "c-Myc" EXACT [UniProtKB:P01106] synonym: "Transcription factor p64" EXACT [UniProtKB:P01106] xref: EMBL:AAA36340.1 xref: EMBL:AAA59880.1 xref: EMBL:AAA59881.1 xref: EMBL:AAA59882.1 xref: EMBL:AAA88092.1 xref: EMBL:AAH00141.2 xref: EMBL:AAH00917.2 xref: EMBL:AAH58901.2 xref: EMBL:AAO21131.1 xref: EMBL:AAV38573.1 xref: EMBL:BAA01374.2 xref: EMBL:BAA01375.1 xref: EMBL:CAA23831.1 xref: EMBL:CAA25015.2 xref: EMBL:CAA25106.1 xref: EMBL:CAA25288.1 xref: UniProtKB:P01106 xref: UniProtKB:P01107 xref: UniProtKB:Q14026 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005142 ! MYC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005980 ! snip1-myc-2 physical interaction relationship: participates_in CCO:I0005981 ! myc-snip1-1 physical interaction relationship: participates_in CCO:I0005982 ! max-myc-4 physical interaction relationship: participates_in CCO:I0005983 ! snip1-myc-4 physical interaction relationship: participates_in CCO:I0006463 ! snip1-myc-1 physical interaction relationship: participates_in CCO:I0006607 ! snip1-myc physical interaction relationship: participates_in CCO:I0006703 ! trrap-myc-2 physical interaction relationship: participates_in CCO:I0006784 ! myc-snip1 physical interaction relationship: participates_in CCO:I0006785 ! myc-skp2 physical interaction relationship: participates_in CCO:I0006786 ! myc-fbxw7 physical interaction relationship: participates_in CCO:I0006787 ! myc-ep300 physical interaction relationship: participates_in CCO:I0006934 ! snip1-myc-3 physical interaction relationship: participates_in CCO:I0006935 ! myc-snip1-2 physical interaction relationship: participates_in CCO:I0007005 ! myc-zbtb17-1 physical interaction relationship: participates_in CCO:I0007006 ! myc-zbtb17-2 physical interaction relationship: participates_in CCO:I0007007 ! myc-max physical interaction relationship: participates_in CCO:I0007076 ! trrap-myc-1 physical interaction relationship: participates_in CCO:I0007187 ! myc-snip1-3 physical interaction relationship: participates_in CCO:I0007188 ! myc-skp2-1 physical interaction relationship: participates_in CCO:I0007969 ! myc-nmi-1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0013057 ! MYC_HUMAN-Phosphothreonine8 relationship: transforms_into CCO:B0013058 ! MYC_HUMAN-Phosphothreonine58 relationship: transforms_into CCO:B0013059 ! MYC_HUMAN-Phosphoserine62 relationship: transforms_into CCO:B0013060 ! MYC_HUMAN-N6-acetyllysine143 relationship: transforms_into CCO:B0013061 ! MYC_HUMAN-N6-acetyllysine157 relationship: transforms_into CCO:B0013062 ! MYC_HUMAN-N6-acetyllysine275 relationship: transforms_into CCO:B0013063 ! MYC_HUMAN-N6-acetyllysine317 relationship: transforms_into CCO:B0013064 ! MYC_HUMAN-N6-acetyllysine323 relationship: transforms_into CCO:B0013065 ! MYC_HUMAN-N6-acetyllysine371 [Term] id: CCO:B0001467 name: RASH_HUMAN def: "GTPase HRas precursor" [UniProtKB:P01112] synonym: "c-H-ras" EXACT [UniProtKB:P01112] synonym: "H-Ras-1" EXACT [UniProtKB:P01112] synonym: "Ha-Ras" EXACT [UniProtKB:P01112] synonym: "p21ras" EXACT [UniProtKB:P01112] synonym: "Transforming protein p21" EXACT [UniProtKB:P01112] xref: EMBL:AAA35685.1 xref: EMBL:AAB02605.1 xref: EMBL:AAH95471.1 xref: EMBL:AAM12630.1 xref: EMBL:AAV38228.1 xref: EMBL:CAG38816.1 xref: EMBL:CAG47067.1 xref: UniProtKB:P01112 xref: UniProtKB:Q14080 xref: UniProtKB:Q6FHV9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005433 ! HRAS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007001 ! hras1-rassf5-2 physical interaction relationship: transforms_into CCO:B0013715 ! RASH_HUMAN-Cysteine methyl ester186 relationship: transforms_into CCO:B0041173 ! RASH_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0041174 ! RASH_HUMAN-N-acetylthreonine2 [Term] id: CCO:B0001468 name: RASK_HUMAN def: "GTPase KRas precursor" [UniProtKB:P01116] synonym: "c-K-ras" EXACT [UniProtKB:P01116] synonym: "c-Ki-ras" EXACT [UniProtKB:P01116] synonym: "K-Ras 2" EXACT [UniProtKB:P01116] synonym: "Ki-Ras" EXACT [UniProtKB:P01116] xref: EMBL:AAA35683.1 xref: EMBL:AAA36149.1 xref: EMBL:AAA36554.1 xref: EMBL:AAA36557.1 xref: EMBL:AAB41942.1 xref: EMBL:AAB59444.1 xref: EMBL:AAB59445.1 xref: EMBL:AAH13572.1 xref: EMBL:AAM12631.1 xref: EMBL:AAP35817.1 xref: EMBL:CAA25828.1 xref: EMBL:CAA26593.1 xref: UniProtKB:P01116 xref: UniProtKB:P01118 xref: UniProtKB:Q96D10 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005434 ! KRAS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007375 ! kras-rassf2-1 physical interaction relationship: participates_in CCO:I0007412 ! krs-rassf2-2 direct interaction relationship: transforms_into CCO:B0013716 ! RASK_HUMAN-ester186 relationship: transforms_into CCO:B0041175 ! RASK_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0041176 ! RASK_HUMAN-N-acetylthreonine2 [Term] id: CCO:B0001470 name: EGF_HUMAN def: "Pro-epidermal growth factor precursor" [UniProtKB:P01133] synonym: "EGF" EXACT [UniProtKB:P01133] xref: EMBL:AAH93731.1 xref: EMBL:AAI13462.1 xref: EMBL:AAR84237.1 xref: EMBL:CAA28240.1 xref: UniProtKB:P01133 xref: UniProtKB:Q52LZ6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004553 ! EGF_human relationship: has_function CCO:F0001456 ! epidermal growth factor receptor binding relationship: has_function CCO:F0001457 ! epidermal growth factor receptor activating ligand activity relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001702 ! growth factor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000201 ! extracellular region relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: located_in CCO:C0001130 ! platelet alpha granule lumen relationship: participates_in CCO:I0005972 ! egf-egfr-2 direct interaction relationship: participates_in CCO:I0006532 ! egf-egfr-1 direct interaction relationship: participates_in CCO:I0007503 ! egf-egfr-3 direct interaction relationship: participates_in CCO:P0000251 ! positive regulation of mitosis [Term] id: CCO:B0001471 name: TGFB1_HUMAN def: "Transforming growth factor beta-1 precursor" [UniProtKB:P01137] synonym: "TGF-beta-1" EXACT [UniProtKB:P01137] xref: EMBL:AAA36735.1 xref: EMBL:AAH00125.1 xref: EMBL:AAH01180.1 xref: EMBL:AAH22242.1 xref: EMBL:AAP35909.1 xref: EMBL:CAA26580.1 xref: EMBL:CAA29283.1 xref: UniProtKB:P01137 xref: UniProtKB:Q9UCG4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005773 ! TGFB1_human relationship: has_function CCO:F0001462 ! transforming growth factor beta receptor binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001702 ! growth factor activity relationship: has_function CCO:F0003205 ! transcription activator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000201 ! extracellular region relationship: located_in CCO:C0000203 ! proteinaceous extracellular matrix relationship: located_in CCO:C0000237 ! extracellular space relationship: located_in CCO:C0000377 ! Golgi lumen relationship: located_in CCO:C0001130 ! platelet alpha granule lumen relationship: participates_in CCO:I0006333 ! tgfb1-bapp-1 physical interaction relationship: participates_in CCO:I0007784 ! tgfb1-tgfb2-bapp-2 physical interaction relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001479 name: ANXA1_HUMAN def: "Annexin A1" [UniProtKB:P04083] synonym: "Annexin I" EXACT [UniProtKB:P04083] synonym: "Annexin-1" EXACT [UniProtKB:P04083] synonym: "Calpactin II" EXACT [UniProtKB:P04083] synonym: "Chromobindin-9" EXACT [UniProtKB:P04083] synonym: "Lipocortin I" EXACT [UniProtKB:P04083] synonym: "p35" EXACT [UniProtKB:P04083] synonym: "Phospholipase A2 inhibitory protein" EXACT [UniProtKB:P04083] xref: EMBL:AAH01275.1 xref: EMBL:AAH35993.1 xref: EMBL:CAA29338.1 xref: UniProtKB:P04083 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004068 ! ANXA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0010550 ! ANXA1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0010551 ! ANXA1_HUMAN-Phosphoserine5 relationship: transforms_into CCO:B0010552 ! ANXA1_HUMAN-Phosphotyrosine21 relationship: transforms_into CCO:B0010553 ! ANXA1_HUMAN-Phosphothreonine24 relationship: transforms_into CCO:B0010554 ! ANXA1_HUMAN-Phosphoserine27 relationship: transforms_into CCO:B0010555 ! ANXA1_HUMAN-Phosphotyrosine207 [Term] id: CCO:B0001481 name: HSP1_HUMAN def: "Sperm protamine-P1" [UniProtKB:P04553] synonym: "Cysteine-rich protamine" EXACT [UniProtKB:P04553] xref: EMBL:AAA60191.1 xref: EMBL:AAA63249.1 xref: EMBL:AAB29321.2 xref: EMBL:AAC50486.1 xref: EMBL:AAF34620.1 xref: EMBL:AAH03673.1 xref: EMBL:AAP35392.1 xref: EMBL:CAA68499.1 xref: EMBL:CAA87065.1 xref: UniProtKB:P04553 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004833 ! PRM1_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000113 ! nucleosome relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000296 ! chromosome relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation [Term] id: CCO:B0001482 name: PRM2_HUMAN def: "Protamine-2" [UniProtKB:P04554] synonym: "Sperm histone P2" EXACT [UniProtKB:P04554] synonym: "Sperm protamine-P2" EXACT [UniProtKB:P04554] xref: EMBL:AAA63250.1 xref: EMBL:AAC50487.1 xref: EMBL:AAF34632.1 xref: EMBL:AAH05303.1 xref: EMBL:AAH66338.1 xref: EMBL:CAA30710.1 xref: EMBL:CAA87066.1 xref: UniProtKB:P04554 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005378 ! PRM2_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000113 ! nucleosome relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000296 ! chromosome relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation [Term] id: CCO:B0001483 name: P53_HUMAN def: "Cellular tumor antigen p53" [UniProtKB:P04637] synonym: "Antigen NY-CO-13" EXACT [UniProtKB:P04637] synonym: "Phosphoprotein p53" EXACT [UniProtKB:P04637] synonym: "Tumor suppressor p53" EXACT [UniProtKB:P04637] xref: EMBL:AAA59987.1 xref: EMBL:AAA59988.1 xref: EMBL:AAA59989.1 xref: EMBL:AAA61211.1 xref: EMBL:AAA61212.1 xref: EMBL:AAB39322.1 xref: EMBL:AAC12971.1 xref: EMBL:AAD28535.1 xref: EMBL:AAD28628.1 xref: EMBL:AAF36354.1 xref: EMBL:AAF36355.1 xref: EMBL:AAF36356.1 xref: EMBL:AAF36357.1 xref: EMBL:AAF36358.1 xref: EMBL:AAF36359.1 xref: EMBL:AAF36360.1 xref: EMBL:AAF36361.1 xref: EMBL:AAF36362.1 xref: EMBL:AAF36374.1 xref: EMBL:AAF36375.1 xref: EMBL:AAF36376.1 xref: EMBL:AAF36377.1 xref: EMBL:AAF36378.1 xref: EMBL:AAF36379.1 xref: EMBL:AAF36380.1 xref: EMBL:AAF36381.1 xref: EMBL:AAF36382.1 xref: EMBL:AAF63442.1 xref: EMBL:AAF63443.1 xref: EMBL:AAG28785.1 xref: EMBL:AAH03596.1 xref: EMBL:AAK76358.1 xref: EMBL:AAK76359.1 xref: EMBL:AAP30003.1 xref: EMBL:AAQ90158.1 xref: EMBL:AAR10356.1 xref: EMBL:AAR13239.1 xref: EMBL:AAV80424.1 xref: EMBL:BAC16799.1 xref: EMBL:CAA25652.1 xref: EMBL:CAA26306.1 xref: EMBL:CAA38095.1 xref: EMBL:CAA42626.1 xref: EMBL:CAA42627.1 xref: EMBL:CAA42628.1 xref: EMBL:CAA42629.1 xref: EMBL:CAA42630.1 xref: EMBL:CAA42631.1 xref: EMBL:CAA42632.1 xref: EMBL:CAA42633.1 xref: EMBL:CAA42634.1 xref: EMBL:CAA42635.1 xref: UniProtKB:P04637 xref: UniProtKB:Q15086 xref: UniProtKB:Q15087 xref: UniProtKB:Q15088 xref: UniProtKB:Q16535 xref: UniProtKB:Q16807 xref: UniProtKB:Q16808 xref: UniProtKB:Q16809 xref: UniProtKB:Q16810 xref: UniProtKB:Q16811 xref: UniProtKB:Q16848 xref: UniProtKB:Q86UG1 xref: UniProtKB:Q8J016 xref: UniProtKB:Q99659 xref: UniProtKB:Q9BTM4 xref: UniProtKB:Q9HAQ8 xref: UniProtKB:Q9NP68 xref: UniProtKB:Q9NPJ2 xref: UniProtKB:Q9NZD0 xref: UniProtKB:Q9UBI2 xref: UniProtKB:Q9UQ61 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005245 ! TP53_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005741 ! mageb18-tp53 physical interaction relationship: participates_in CCO:I0005862 ! dvl2-tp53 physical interaction relationship: participates_in CCO:I0005976 ! nedd8-tp53-1 neddylation relationship: participates_in CCO:I0005978 ! e6-e6ap-tp53 physical interaction relationship: participates_in CCO:I0005979 ! e6ap-tp53 physical interaction relationship: participates_in CCO:I0006029 ! npm1-tp53-2 physical interaction relationship: participates_in CCO:I0006033 ! wrn-p53-3 colocalization relationship: participates_in CCO:I0006070 ! tp53-nfya-8 colocalization relationship: participates_in CCO:I0006221 ! mdm2-daxx physical interaction relationship: participates_in CCO:I0006222 ! ubp7-daxx physical interaction relationship: participates_in CCO:I0006246 ! tp53-fbxo11-3 physical interaction relationship: participates_in CCO:I0006319 ! npm1-tp53-3 physical interaction relationship: participates_in CCO:I0006320 ! npm1-tp53-4 physical interaction relationship: participates_in CCO:I0006344 ! tp53-lap-2 colocalization relationship: participates_in CCO:I0006528 ! mdm2-npm1-6 physical interaction relationship: participates_in CCO:I0006529 ! pias1-p53-1 direct interaction relationship: participates_in CCO:I0006530 ! pias1-p53-2 direct interaction relationship: participates_in CCO:I0006531 ! pias1-p53-3 direct interaction relationship: participates_in CCO:I0006535 ! wrn-p53-1 direct interaction relationship: participates_in CCO:I0006536 ! wrn-p53-2 direct interaction relationship: participates_in CCO:I0006554 ! tp53-lip physical interaction relationship: participates_in CCO:I0006555 ! tp53-cebpb physical interaction relationship: participates_in CCO:I0006562 ! tp53-nfya-2 physical interaction relationship: participates_in CCO:I0006564 ! tp53-nfya-3 physical interaction relationship: participates_in CCO:I0006565 ! tp53-nfya-4 physical interaction relationship: participates_in CCO:I0006567 ! tp53-nfya-7 physical interaction relationship: participates_in CCO:I0006612 ! p53-sin3a-2 physical interaction relationship: participates_in CCO:I0006655 ! dvl2-tp53-1 physical interaction relationship: participates_in CCO:I0006656 ! mageb18-tp53-1 physical interaction relationship: participates_in CCO:I0006657 ! scamp1-tp53 physical interaction relationship: participates_in CCO:I0006698 ! tp53-tbp1 physical interaction relationship: participates_in CCO:I0006699 ! tp53-tbp-2 physical interaction relationship: participates_in CCO:I0006763 ! usp7-tp53-5 physical interaction relationship: participates_in CCO:I0006780 ! tp53-fbxo11-2 direct interaction relationship: participates_in CCO:I0006795 ! tp53-hdac1 physical interaction relationship: participates_in CCO:I0006806 ! tp53-pias4-3 physical interaction relationship: participates_in CCO:I0006857 ! p53-crebbp-6 physical interaction relationship: participates_in CCO:I0006873 ! tp53-hipk1-2 physical interaction relationship: participates_in CCO:I0006900 ! atr-tp53-1 phosphorylation relationship: participates_in CCO:I0006917 ! nfya-tp53 physical interaction relationship: participates_in CCO:I0006918 ! nfya-tp53-1 physical interaction relationship: participates_in CCO:I0006919 ! tp53-nfya-5 physical interaction relationship: participates_in CCO:I0006920 ! tp53-nfya-6 physical interaction relationship: participates_in CCO:I0006921 ! nfya-tp53-2 physical interaction relationship: participates_in CCO:I0006926 ! p53-mdm2-2 physical interaction relationship: participates_in CCO:I0006970 ! huew1-tp53-1 physical interaction relationship: participates_in CCO:I0006971 ! tp53-huew1-2 physical interaction relationship: participates_in CCO:I0006980 ! gnl3-p53 physical interaction relationship: participates_in CCO:I0006990 ! p53-pml-1 physical interaction relationship: participates_in CCO:I0007027 ! tp53-pias4-2 physical interaction relationship: participates_in CCO:I0007083 ! p53-crebbp-2 physical interaction relationship: participates_in CCO:I0007084 ! p53-crebbp-3 physical interaction relationship: participates_in CCO:I0007085 ! p53-crebbp-4 physical interaction relationship: participates_in CCO:I0007086 ! p53-crebbp-5 physical interaction relationship: participates_in CCO:I0007099 ! mdm2-p53-1 direct interaction relationship: participates_in CCO:I0007166 ! tp53-tp53bp1-1 direct interaction relationship: participates_in CCO:I0007233 ! rad51-tp53-1 physical interaction relationship: participates_in CCO:I0007234 ! rad51-tp53-2 physical interaction relationship: participates_in CCO:I0007241 ! hd-p53-2 physical interaction relationship: participates_in CCO:I0007242 ! p53-crebbp-1 physical interaction relationship: participates_in CCO:I0007243 ! p53-sin3a-1 physical interaction relationship: participates_in CCO:I0007322 ! mapkapk5-tp53 phosphorylation relationship: participates_in CCO:I0007324 ! mapkapk5-tp53-1 phosphorylation relationship: participates_in CCO:I0007325 ! mapk11-tp53-1 phosphorylation relationship: participates_in CCO:I0007352 ! cables1-tp53-3 physical interaction relationship: participates_in CCO:I0007361 ! p53-p300-1 physical interaction relationship: participates_in CCO:I0007362 ! p53-jmy-1 physical interaction relationship: participates_in CCO:I0007380 ! phb-tp53-2 colocalization relationship: participates_in CCO:I0007381 ! ubp7-daxx-6 physical interaction relationship: participates_in CCO:I0007384 ! usp7-tp53 physical interaction relationship: participates_in CCO:I0007385 ! usp7-tp53-1 physical interaction relationship: participates_in CCO:I0007386 ! usp7-tp53-2 physical interaction relationship: participates_in CCO:I0007434 ! tp53-hipk1-1 physical interaction relationship: participates_in CCO:I0007449 ! bmx-tp53-1 physical interaction relationship: participates_in CCO:I0007451 ! tp53-lap-1 physical interaction relationship: participates_in CCO:I0007461 ! usp7-tp53-3 direct interaction relationship: participates_in CCO:I0007467 ! tp53-tp53bp2-1 direct interaction relationship: participates_in CCO:I0007491 ! phb-tp53-4 colocalization relationship: participates_in CCO:I0007568 ! tp53-huew1-1 physical interaction relationship: participates_in CCO:I0007577 ! tp53-btbd2-1 physical interaction relationship: participates_in CCO:I0007578 ! p53-wrn-1 direct interaction relationship: participates_in CCO:I0007579 ! p53-wrn-2 direct interaction relationship: participates_in CCO:I0007581 ! p53-rpa1-8 physical interaction relationship: participates_in CCO:I0007707 ! tp53-nfya physical interaction relationship: participates_in CCO:I0007737 ! hd-p53-3 physical interaction relationship: participates_in CCO:I0007738 ! hd-p53-4 physical interaction relationship: participates_in CCO:I0007802 ! phb-tp53-1 colocalization relationship: participates_in CCO:I0007808 ! ubp7-daxx-7 physical interaction relationship: participates_in CCO:I0007809 ! ubp7-daxx-8 physical interaction relationship: participates_in CCO:I0007810 ! ubp7-daxx-9 physical interaction relationship: participates_in CCO:I0007811 ! mdm2-daxx-2 physical interaction relationship: participates_in CCO:I0007824 ! tp53-nfya-1 physical interaction relationship: participates_in CCO:I0007835 ! tp53-fbxo11-1 physical interaction relationship: participates_in CCO:I0007849 ! hd-p53-1 physical interaction relationship: participates_in CCO:I0007924 ! phb-tp53 colocalization relationship: participates_in CCO:I0007931 ! usp7-tp53-4 physical interaction relationship: participates_in CCO:I0007949 ! tp53-hmgb1 physical interaction relationship: participates_in CCO:I0007982 ! cdkn2c-tp53 physical interaction relationship: participates_in CCO:I0007987 ! erh-tp53 physical interaction relationship: participates_in CCO:I0007993 ! znf24-tp53 physical interaction relationship: participates_in CCO:I0007995 ! arih2-tp53 physical interaction relationship: participates_in CCO:I0007999 ! btbd2-tp53 physical interaction relationship: participates_in CCO:I0008000 ! ccl18-tp53 physical interaction relationship: participates_in CCO:I0008003 ! cdc42-tp53 physical interaction relationship: participates_in CCO:I0008010 ! eif2s2-tp53 physical interaction relationship: participates_in CCO:I0008018 ! lama4-tp53 physical interaction relationship: participates_in CCO:I0008021 ! mad2l1bp-tp53 physical interaction relationship: participates_in CCO:I0008023 ! mphosph6-tp53 physical interaction relationship: participates_in CCO:I0008029 ! pafah1b3-tp53 physical interaction relationship: participates_in CCO:I0008030 ! pcdha4-tp53 physical interaction relationship: participates_in CCO:I0008033 ! pp-tp53 physical interaction relationship: participates_in CCO:I0008037 ! psmd11-tp53 physical interaction relationship: participates_in CCO:I0008048 ! sat-tp53 physical interaction relationship: participates_in CCO:I0008051 ! serpinb9-tp53 physical interaction relationship: participates_in CCO:I0008052 ! sma3-tp53 physical interaction relationship: participates_in CCO:I0008054 ! snrpn-tp53 physical interaction relationship: participates_in CCO:I0008055 ! sult1e1-tp53 physical interaction relationship: participates_in CCO:I0008059 ! tk1-tp53 physical interaction relationship: participates_in CCO:I0008060 ! tmsb4x-tp53 physical interaction relationship: participates_in CCO:I0008065 ! anxa3-tp53 physical interaction relationship: participates_in CCO:I0008068 ! arl3-tp53 physical interaction relationship: participates_in CCO:I0008069 ! atf3-tp53 physical interaction relationship: participates_in CCO:I0008072 ! bcr-tp53 physical interaction relationship: participates_in CCO:I0008076 ! cct5-tp53 physical interaction relationship: participates_in CCO:I0008089 ! cox17-tp53 physical interaction relationship: participates_in CCO:I0008097 ! dleu1-tp53 physical interaction relationship: participates_in CCO:I0008108 ! fxyd6-tp53 physical interaction relationship: participates_in CCO:I0008114 ! gstm4-tp53 physical interaction relationship: participates_in CCO:I0008124 ! hspb1-tp53 physical interaction relationship: participates_in CCO:I0008138 ! np-tp53 physical interaction relationship: participates_in CCO:I0008168 ! stx5a-tp53 physical interaction relationship: participates_in CCO:I0008177 ! tp53ap1-tp53 physical interaction relationship: participates_in CCO:I0008187 ! wdr33-tp53 physical interaction relationship: participates_in CCO:I0008265 ! c16orf24-tp53 physical interaction relationship: participates_in CCO:I0008319 ! s100a8-tp53 physical interaction relationship: participates_in CCO:I0008351 ! zcchc10-tp53 physical interaction relationship: participates_in CCO:I0008401 ! kiaa0087-tp53 physical interaction relationship: participates_in CCO:I0008424 ! rab4a-tp53 physical interaction relationship: participates_in CCO:I0008440 ! thap8-tp53 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013340 ! P53_HUMAN-Phosphoserine15 relationship: transforms_into CCO:B0013341 ! P53_HUMAN-Phosphothreonine18 relationship: transforms_into CCO:B0013342 ! P53_HUMAN-Phosphoserine46 relationship: transforms_into CCO:B0013343 ! P53_HUMAN-Phosphothreonine55 relationship: transforms_into CCO:B0013344 ! P53_HUMAN-Phosphoserine99 relationship: transforms_into CCO:B0013345 ! P53_HUMAN-N6-acetyllysine305 relationship: transforms_into CCO:B0013346 ! P53_HUMAN-Phosphoserine315 relationship: transforms_into CCO:B0013347 ! P53_HUMAN-N6-acetyllysine373 relationship: transforms_into CCO:B0013348 ! P53_HUMAN-N6-acetyllysine382 relationship: transforms_into CCO:B0013349 ! P53_HUMAN-O-(5'-phospho-RNA)-serine392 relationship: transforms_into CCO:B0013350 ! P53_HUMAN-Phosphoserine392 relationship: transforms_into CCO:B0032856 ! P53_HUMAN-N6-methyllysine370 relationship: transforms_into CCO:B0032857 ! P53_HUMAN-N6-methyllysine372 relationship: transforms_into CCO:B0041169 ! P53_HUMAN-Phosphoserine9 [Term] id: CCO:B0001484 name: IFNW1_HUMAN def: "Interferon omega-1 precursor" [UniProtKB:P05000] synonym: "Interferon alpha-II-1" EXACT [UniProtKB:P05000] xref: EMBL:AAA52724.1 xref: EMBL:AAA70091.1 xref: EMBL:AAH69095.1 xref: EMBL:AAI17291.1 xref: EMBL:AAI17293.1 xref: EMBL:AAV49320.1 xref: EMBL:CAA01011.1 xref: EMBL:CAA26501.1 xref: EMBL:CAA41626.1 xref: EMBL:CAH70158.1 xref: EMBL:EAW58624.1 xref: UniProtKB:P05000 xref: UniProtKB:Q13168 xref: UniProtKB:Q5U802 xref: UniProtKB:Q5VWD0 xref: UniProtKB:Q7M4P5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004866 ! IFNW1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001485 name: INHA_HUMAN def: "Inhibin alpha chain precursor" [UniProtKB:P05111] xref: EMBL:AAA59166.1 xref: EMBL:AAA59167.1 xref: EMBL:AAH06391.1 xref: EMBL:AAP35600.1 xref: EMBL:CAA28040.1 xref: UniProtKB:P05111 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004896 ! INHA_human relationship: has_function CCO:F0001407 ! receptor binding relationship: has_function CCO:F0001427 ! cytokine activity relationship: has_function CCO:F0001479 ! hormone activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001702 ! growth factor activity relationship: has_function CCO:F0003570 ! activin inhibitor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000201 ! extracellular region relationship: located_in CCO:C0001778 ! inhibin A complex relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: participates_in CCO:P0000346 ! regulation of cell cycle [Term] id: CCO:B0001489 name: K1C18_HUMAN def: "Keratin, type I cytoskeletal 18" [UniProtKB:P05783] synonym: "Cell proliferation-inducing gene 46 protein" EXACT [UniProtKB:P05783] synonym: "CK-18" EXACT [UniProtKB:P05783] synonym: "Cytokeratin-18" EXACT [UniProtKB:P05783] synonym: "K18" EXACT [UniProtKB:P05783] synonym: "Keratin-18" EXACT [UniProtKB:P05783] xref: EMBL:AAA59461.1 xref: EMBL:AAH00180.1 xref: EMBL:AAH00698.1 xref: EMBL:AAH04253.1 xref: EMBL:AAH08636.1 xref: EMBL:AAH20982.1 xref: EMBL:AAH72017.1 xref: EMBL:AAV38219.1 xref: EMBL:AAX07828.1 xref: EMBL:BAD96813.1 xref: EMBL:CAA31369.1 xref: EMBL:CAA31375.1 xref: EMBL:CAA31377.1 xref: UniProtKB:P05783 xref: UniProtKB:Q53G38 xref: UniProtKB:Q5U0N8 xref: UniProtKB:Q9BW26 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004923 ! KRT18_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005746 ! krt18-q9bvr6 physical interaction relationship: participates_in CCO:I0005766 ! krt15-krt18 physical interaction relationship: participates_in CCO:I0005838 ! krt18-ldoc1 physical interaction relationship: participates_in CCO:I0005839 ! exoc8-krt18 physical interaction relationship: participates_in CCO:I0005902 ! hgs-krt18 physical interaction relationship: participates_in CCO:I0005903 ! krt18-nme7 physical interaction relationship: participates_in CCO:I0006664 ! npm_alk-gak physical interaction relationship: participates_in CCO:I0006677 ! grb2-egfr-1 physical interaction relationship: participates_in CCO:I0007196 ! krt18-shc1-1 colocalization relationship: participates_in CCO:I0007341 ! krt8-krt18 physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012460 ! K1C18_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0012461 ! K1C18_HUMAN-Phosphoserine7 relationship: transforms_into CCO:B0012462 ! K1C18_HUMAN-Phosphothreonine8 relationship: transforms_into CCO:B0012463 ! K1C18_HUMAN-Phosphothreonine11 relationship: transforms_into CCO:B0012464 ! K1C18_HUMAN-Phosphoserine15 relationship: transforms_into CCO:B0012465 ! K1C18_HUMAN-Phosphoserine18 relationship: transforms_into CCO:B0012466 ! K1C18_HUMAN-Phosphoserine30 relationship: transforms_into CCO:B0012467 ! K1C18_HUMAN-Phosphoserine31 relationship: transforms_into CCO:B0012468 ! K1C18_HUMAN-Phosphoserine34 relationship: transforms_into CCO:B0012469 ! K1C18_HUMAN-Phosphotyrosine36 relationship: transforms_into CCO:B0012470 ! K1C18_HUMAN-Phosphoserine42 relationship: transforms_into CCO:B0012471 ! K1C18_HUMAN-Phosphoserine53 relationship: transforms_into CCO:B0012472 ! K1C18_HUMAN-Phosphoserine60 relationship: transforms_into CCO:B0012473 ! K1C18_HUMAN-Phosphoserine401 relationship: transforms_into CCO:B0012474 ! K1C18_HUMAN-Phosphothreonine404 [Term] id: CCO:B0001490 name: LCK_HUMAN def: "Proto-oncogene tyrosine-protein kinase LCK" [UniProtKB:P06239] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P06239] synonym: "LSK" EXACT [UniProtKB:P06239] synonym: "Lymphocyte cell-specific protein-tyrosine kinase" EXACT [UniProtKB:P06239] synonym: "p56-LCK" EXACT [UniProtKB:P06239] synonym: "T cell-specific protein-tyrosine kinase" EXACT [UniProtKB:P06239] xref: EMBL:AAA18225.1 xref: EMBL:AAA59501.1 xref: EMBL:AAA59502.1 xref: EMBL:AAA59503.1 xref: EMBL:AAC50287.1 xref: EMBL:AAF34794.1 xref: EMBL:AAH13200.1 xref: EMBL:CAA28165.1 xref: EMBL:CAA28691.1 xref: EMBL:CAA29667.1 xref: EMBL:CAA31884.1 xref: EMBL:CAA32211.1 xref: EMBL:CAI22320.1 xref: EMBL:CAI22321.1 xref: UniProtKB:P06239 xref: UniProtKB:P07100 xref: UniProtKB:Q12850 xref: UniProtKB:Q13152 xref: UniProtKB:Q5TDH8 xref: UniProtKB:Q5TDH9 xref: UniProtKB:Q96DW4 xref: UniProtKB:Q9NYT8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004974 ! LCK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006623 ! khdrbs1-lck-1 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007195 ! lck-ptprc physical interaction relationship: participates_in CCO:I0007519 ! lck-khdrbs1 physical interaction relationship: participates_in CCO:I0007965 ! lck-sam68-1 physical interaction relationship: transforms_into CCO:B0012690 ! LCK_HUMAN-Phosphoserine162 relationship: transforms_into CCO:B0012691 ! LCK_HUMAN-Phosphotyrosine192 relationship: transforms_into CCO:B0012692 ! LCK_HUMAN-Phosphoserine213 relationship: transforms_into CCO:B0012693 ! LCK_HUMAN-Phosphotyrosine394 relationship: transforms_into CCO:B0012694 ! LCK_HUMAN-Phosphothreonine501 relationship: transforms_into CCO:B0012695 ! LCK_HUMAN-Phosphotyrosine505 [Term] id: CCO:B0001491 name: RB_HUMAN def: "Retinoblastoma-associated protein" [UniProtKB:P06400] synonym: "p105-Rb" EXACT [UniProtKB:P06400] synonym: "pp110" EXACT [UniProtKB:P06400] synonym: "pRb" EXACT [UniProtKB:P06400] synonym: "Rb" EXACT [UniProtKB:P06400] xref: EMBL:AAA53483.1 xref: EMBL:AAA53484.1 xref: EMBL:AAA65735.1 xref: EMBL:AAA65736.1 xref: EMBL:AAA65737.1 xref: EMBL:AAA65738.1 xref: EMBL:AAA65739.1 xref: EMBL:AAA65740.1 xref: EMBL:AAA65741.1 xref: EMBL:AAA69806.1 xref: EMBL:AAA69807.1 xref: EMBL:AAA69808.1 xref: EMBL:AAB59465.1 xref: EMBL:AAB59467.1 xref: EMBL:AAB59471.1 xref: EMBL:AAB59473.1 xref: EMBL:AAB59482.1 xref: EMBL:AAH39060.1 xref: EMBL:AAH40540.1 xref: EMBL:AAN64133.1 xref: EMBL:CAA34462.1 xref: EMBL:CAH70901.1 xref: EMBL:CAH72243.1 xref: UniProtKB:P06400 xref: UniProtKB:P78499 xref: UniProtKB:Q5VW46 xref: UniProtKB:Q8IZL4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005454 ! RB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006052 ! pa2g4-rb1-1 physical interaction relationship: participates_in CCO:I0006053 ! rb1-pa2g4-2 physical interaction relationship: participates_in CCO:I0006054 ! pa2g4-rb1-2 physical interaction relationship: participates_in CCO:I0006196 ! rb1-taf1-1 physical interaction relationship: participates_in CCO:I0006457 ! ahr-rb1 physical interaction relationship: participates_in CCO:I0006458 ! ahr-rb1-1 physical interaction relationship: participates_in CCO:I0006561 ! morf4l2-rb1-1 physical interaction relationship: participates_in CCO:I0007003 ! e2f3-rb physical interaction relationship: participates_in CCO:I0007008 ! e2f3-rb-1 physical interaction relationship: participates_in CCO:I0007009 ! e2f3-rb-2 physical interaction relationship: participates_in CCO:I0007309 ! rb1-hdac1 physical interaction relationship: participates_in CCO:I0007350 ! cdk2-rb1-1 phosphorylation relationship: participates_in CCO:I0007351 ! cdk2-rb1-2 phosphorylation relationship: participates_in CCO:I0007418 ! rb1-pa2g4-1 physical interaction relationship: participates_in CCO:I0007496 ! rb1-e2f1 physical interaction relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: participates_in CCO:P0000039 ! M phase relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: participates_in CCO:P0000313 ! G1 phase relationship: transforms_into CCO:B0013799 ! RB_HUMAN-Phosphoserine249 relationship: transforms_into CCO:B0013800 ! RB_HUMAN-Phosphothreonine252 relationship: transforms_into CCO:B0013801 ! RB_HUMAN-Phosphothreonine373 relationship: transforms_into CCO:B0013802 ! RB_HUMAN-Phosphoserine807 relationship: transforms_into CCO:B0013803 ! RB_HUMAN-Phosphoserine811 relationship: transforms_into CCO:B0013804 ! RB_HUMAN-Phosphothreonine826 [Term] id: CCO:B0001493 name: CDC2_HUMAN def: "Cell division control protein 2 homolog" [UniProtKB:P06493] synonym: "CDK1" EXACT [UniProtKB:P06493] synonym: "Cyclin-dependent kinase 1" EXACT [UniProtKB:P06493] synonym: "EC 2.7.11.22" EXACT [UniProtKB:P06493] synonym: "EC 2.7.11.23" EXACT [UniProtKB:P06493] synonym: "p34 protein kinase" EXACT [UniProtKB:P06493] xref: EMBL:AAH14563.1 xref: EMBL:AAM34793.1 xref: EMBL:AAP35650.1 xref: EMBL:BAA26001.1 xref: EMBL:CAA28963.1 xref: EMBL:CAA68376.1 xref: UniProtKB:O60764 xref: UniProtKB:P06493 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004288 ! CDC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006614 ! cdc2-myt1-1 phosphorylation relationship: participates_in CCO:I0006849 ! lats1-cdc2-1 physical interaction relationship: participates_in CCO:I0006861 ! cdc2-ccnb1-1 physical interaction relationship: participates_in CCO:I0006959 ! pkmyt1-cdc2-1 phosphorylation relationship: participates_in CCO:I0007087 ! pkmyt1-cdc2-2 phosphorylation relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007533 ! cdt1-cdk2-1 physical interaction relationship: participates_in CCO:I0007729 ! lats1-cdc2-2 physical interaction relationship: participates_in CCO:I0007895 ! cyclina1_cdk1_human direct interaction relationship: participates_in CCO:I0007896 ! cyclina2_cdk1_human direct interaction relationship: participates_in CCO:I0007899 ! cyclinb1_cdk1_human direct interaction relationship: participates_in CCO:I0007900 ! cyclinb2_cdk1_human direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000100 ! traversing start control point of mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0011078 ! CDC2_HUMAN-Phosphothreonine14 relationship: transforms_into CCO:B0011079 ! CDC2_HUMAN-Phosphotyrosine15 relationship: transforms_into CCO:B0011080 ! CDC2_HUMAN-Phosphotyrosine19 relationship: transforms_into CCO:B0011081 ! CDC2_HUMAN-Phosphothreonine161 [Term] id: CCO:B0001494 name: S10A6_HUMAN def: "Protein S100-A6" [UniProtKB:P06703] synonym: "Calcyclin" EXACT [UniProtKB:P06703] synonym: "Growth factor-inducible protein 2A9" EXACT [UniProtKB:P06703] synonym: "MLN 4" EXACT [UniProtKB:P06703] synonym: "PRA" EXACT [UniProtKB:P06703] synonym: "Prolactin receptor-associated protein" EXACT [UniProtKB:P06703] synonym: "S100 calcium-binding protein A6" EXACT [UniProtKB:P06703] xref: EMBL:AAA35886.1 xref: EMBL:AAA51905.1 xref: EMBL:AAA51906.1 xref: EMBL:AAH01431.1 xref: EMBL:AAH09017.1 xref: EMBL:AAK59702.1 xref: EMBL:AAP35611.1 xref: EMBL:CAI14752.1 xref: UniProtKB:P06703 xref: UniProtKB:Q5RHS4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005552 ! S100A6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006057 ! s100b-s100a6-1 physical interaction relationship: participates_in CCO:I0006219 ! s100b-s100a6-3 physical interaction relationship: participates_in CCO:I0006894 ! s100a6-s100a6-1 physical interaction relationship: participates_in CCO:I0006895 ! s100a6-s100b-1 physical interaction relationship: participates_in CCO:I0006896 ! s100b-s100a6-2 physical interaction relationship: participates_in CCO:I0007148 ! s100b-s100a11-s100a6 colocalization relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001495 name: NPM_HUMAN def: "Nucleophosmin" [UniProtKB:P06748] synonym: "NPM" EXACT [UniProtKB:P06748] synonym: "Nucleolar phosphoprotein B23" EXACT [UniProtKB:P06748] synonym: "Nucleolar protein NO38" EXACT [UniProtKB:P06748] synonym: "Numatrin" EXACT [UniProtKB:P06748] xref: EMBL:AAA36380.1 xref: EMBL:AAA36385.1 xref: EMBL:AAA36473.1 xref: EMBL:AAA36474.1 xref: EMBL:AAA58386.1 xref: EMBL:AAA58698.1 xref: EMBL:AAB00112.1 xref: EMBL:AAB00113.1 xref: EMBL:AAB94739.1 xref: EMBL:AAH02398.1 xref: EMBL:AAH08495.1 xref: EMBL:AAH09623.1 xref: EMBL:AAH12566.1 xref: EMBL:AAH14349.1 xref: EMBL:AAH16716.1 xref: EMBL:AAH16768.1 xref: EMBL:AAH16824.1 xref: EMBL:AAH21668.1 xref: EMBL:AAH21983.1 xref: EMBL:AAH50628.1 xref: EMBL:AAP35657.1 xref: EMBL:AAQ24860.1 xref: EMBL:AAW67752.1 xref: EMBL:AAW67753.1 xref: EMBL:AAW67754.1 xref: EMBL:AAW67755.1 xref: EMBL:AAW67756.1 xref: EMBL:AAW67757.1 xref: EMBL:AAW67758.1 xref: EMBL:ABC40399.1 xref: EMBL:BAA08343.1 xref: EMBL:CAA34809.1 xref: UniProtKB:P06748 xref: UniProtKB:P08693 xref: UniProtKB:Q12826 xref: UniProtKB:Q13440 xref: UniProtKB:Q13441 xref: UniProtKB:Q14115 xref: UniProtKB:Q5EU94 xref: UniProtKB:Q5EU95 xref: UniProtKB:Q5EU96 xref: UniProtKB:Q5EU97 xref: UniProtKB:Q5EU98 xref: UniProtKB:Q5EU99 xref: UniProtKB:Q6V962 xref: UniProtKB:Q8WTW5 xref: UniProtKB:Q96AT6 xref: UniProtKB:Q96DC4 xref: UniProtKB:Q96EA5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005212 ! NPM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006029 ! npm1-tp53-2 physical interaction relationship: participates_in CCO:I0006318 ! mdm2-npm1-4 physical interaction relationship: participates_in CCO:I0006319 ! npm1-tp53-3 physical interaction relationship: participates_in CCO:I0006320 ! npm1-tp53-4 physical interaction relationship: participates_in CCO:I0006345 ! pa2g4-npm-1 colocalization relationship: participates_in CCO:I0006346 ! pa2g4-npm-2 colocalization relationship: participates_in CCO:I0006392 ! map3k14-rara physical interaction relationship: participates_in CCO:I0006505 ! q9btt4-q71f56-1 physical interaction relationship: participates_in CCO:I0006506 ! q9nwa0-q71f56-1 physical interaction relationship: participates_in CCO:I0006507 ! q9nx70-q71f56-1 physical interaction relationship: participates_in CCO:I0006527 ! mdm2-npm1-2 physical interaction relationship: participates_in CCO:I0006548 ! top1-npm1 physical interaction relationship: participates_in CCO:I0006549 ! top1-hnrpc physical interaction relationship: participates_in CCO:I0006673 ! hrmt1l1-rara-1 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007326 ! ncoa6-rara-1 physical interaction relationship: participates_in CCO:I0007327 ! ncoa6-rara-2 physical interaction relationship: participates_in CCO:I0007753 ! mdm2-npm1-1 physical interaction relationship: participates_in CCO:I0007786 ! top1-2 physical interaction relationship: participates_in CCO:I0007874 ! cdkn2a-huew1-1 physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:P0000108 ! centrosome cycle relationship: transforms_into CCO:B0013246 ! NPM_HUMAN-Phosphoserine4 relationship: transforms_into CCO:B0013247 ! NPM_HUMAN-Phosphoserine10 relationship: transforms_into CCO:B0013248 ! NPM_HUMAN-Phosphoserine70 relationship: transforms_into CCO:B0013249 ! NPM_HUMAN-Phosphothreonine75 relationship: transforms_into CCO:B0013250 ! NPM_HUMAN-Phosphothreonine95 relationship: transforms_into CCO:B0013251 ! NPM_HUMAN-Phosphoserine106 relationship: transforms_into CCO:B0013252 ! NPM_HUMAN-Phosphoserine125 relationship: transforms_into CCO:B0013253 ! NPM_HUMAN-Phosphoserine137 relationship: transforms_into CCO:B0013254 ! NPM_HUMAN-N6-acetyllysine150 relationship: transforms_into CCO:B0013255 ! NPM_HUMAN-N6-acetyllysine154 relationship: transforms_into CCO:B0013256 ! NPM_HUMAN-Phosphothreonine199 relationship: transforms_into CCO:B0013257 ! NPM_HUMAN-N6-acetyllysine212 relationship: transforms_into CCO:B0013258 ! NPM_HUMAN-Phosphothreonine234 relationship: transforms_into CCO:B0013259 ! NPM_HUMAN-Phosphothreonine237 relationship: transforms_into CCO:B0013260 ! NPM_HUMAN-Phosphoserine254 relationship: transforms_into CCO:B0013261 ! NPM_HUMAN-Phosphoserine260 [Term] id: CCO:B0001496 name: FUMH_HUMAN def: "Fumarate hydratase, mitochondrial precursor" [UniProtKB:P07954] synonym: "EC 4.2.1.2" EXACT [UniProtKB:P07954] synonym: "Fumarase" EXACT [UniProtKB:P07954] xref: EMBL:AAA52483.1 xref: EMBL:AAB66354.1 xref: EMBL:AAD00071.1 xref: EMBL:AAH03108.1 xref: EMBL:AAH17444.1 xref: EMBL:AAP88841.1 xref: UniProtKB:P07954 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004663 ! FH_human relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0000752 ! fumarate hydratase activity relationship: has_function CCO:F0003396 ! lyase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000325 ! mitochondrion relationship: located_in CCO:C0000342 ! mitochondrial matrix relationship: located_in CCO:C0001903 ! tricarboxylic acid cycle enzyme complex relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011900 ! FUMH_HUMAN-N6-acetyllysine66 relationship: transforms_into CCO:B0011901 ! FUMH_HUMAN-N6-acetyllysine115 relationship: transforms_into CCO:B0011902 ! FUMH_HUMAN-N6-acetyllysine477 [Term] id: CCO:B0001497 name: IGF1R_HUMAN def: "Insulin-like growth factor 1 receptor precursor" [UniProtKB:P08069] synonym: "CD221 antigen" EXACT [UniProtKB:P08069] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P08069] synonym: "IGF-I receptor" EXACT [UniProtKB:P08069] synonym: "Insulin-like growth factor I receptor" EXACT [UniProtKB:P08069] xref: EMBL:AAB59399.1 xref: EMBL:AAI13611.1 xref: EMBL:AAI13613.1 xref: EMBL:AAP81165.1 xref: EMBL:CAA28030.1 xref: UniProtKB:P08069 xref: UniProtKB:Q14CV2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004867 ! IGF1R_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006285 ! igf1r-shc1-1 physical interaction relationship: transforms_into CCO:B0012336 ! IGF1R_HUMAN-Phosphotyrosine980 relationship: transforms_into CCO:B0012337 ! IGF1R_HUMAN-Phosphotyrosine1161 relationship: transforms_into CCO:B0012338 ! IGF1R_HUMAN-Phosphotyrosine1165 relationship: transforms_into CCO:B0012339 ! IGF1R_HUMAN-Phosphotyrosine1166 [Term] id: CCO:B0001498 name: INHBA_HUMAN def: "Inhibin beta A chain precursor" [UniProtKB:P08476] synonym: "Activin beta-A chain" EXACT [UniProtKB:P08476] synonym: "EDF" EXACT [UniProtKB:P08476] synonym: "Erythroid differentiation protein" EXACT [UniProtKB:P08476] xref: EMBL:AAA35787.1 xref: EMBL:AAA59168.1 xref: EMBL:AAH07858.1 xref: EMBL:AAQ96861.1 xref: EMBL:CAA28041.1 xref: EMBL:CAA40805.1 xref: EMBL:CAA40806.1 xref: EMBL:CAA51163.1 xref: UniProtKB:P08476 xref: UniProtKB:Q14599 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004897 ! INHBA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001499 name: CD45_HUMAN def: "Leukocyte common antigen precursor" [UniProtKB:P08575] synonym: "CD45 antigen" EXACT [UniProtKB:P08575] synonym: "EC 3.1.3.48" EXACT [UniProtKB:P08575] synonym: "L-CA" EXACT [UniProtKB:P08575] synonym: "T200" EXACT [UniProtKB:P08575] xref: EMBL:AAD15273.2 xref: EMBL:CAA68269.1 xref: EMBL:CAA68669.1 xref: UniProtKB:P08575 xref: UniProtKB:Q16614 xref: UniProtKB:Q9H0Y6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004277 ! PTPRC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007195 ! lck-ptprc physical interaction relationship: participates_in CCO:P0000215 ! regulation of S phase relationship: participates_in CCO:P0000346 ! regulation of cell cycle relationship: transforms_into CCO:B0011049 ! CD45_HUMAN-Phosphoserine995 relationship: transforms_into CCO:B0011050 ! CD45_HUMAN-Phosphoserine1003 relationship: transforms_into CCO:B0011051 ! CD45_HUMAN-Phosphoserine1007 [Term] id: CCO:B0001501 name: K2C7_HUMAN def: "Keratin, type II cytoskeletal 7" [UniProtKB:P08729] synonym: "CK-7" EXACT [UniProtKB:P08729] synonym: "Cytokeratin-7" EXACT [UniProtKB:P08729] synonym: "K7" EXACT [UniProtKB:P08729] synonym: "Keratin-7" EXACT [UniProtKB:P08729] synonym: "Sarcolectin" EXACT [UniProtKB:P08729] xref: EMBL:AAH02700.1 xref: EMBL:AAN64031.1 xref: EMBL:AAN64035.1 xref: EMBL:CAA26956.2 xref: EMBL:CAA31695.1 xref: EMBL:CAB41416.1 xref: UniProtKB:P08729 xref: UniProtKB:Q92676 xref: UniProtKB:Q9BUD8 xref: UniProtKB:Q9Y3R7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004928 ! KRT7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006677 ! grb2-egfr-1 physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:P0000320 ! interphase relationship: transforms_into CCO:B0012481 ! K2C7_HUMAN-Phosphoserine14 relationship: transforms_into CCO:B0012482 ! K2C7_HUMAN-Omega-N-methylated arginine20 relationship: transforms_into CCO:B0012483 ! K2C7_HUMAN-Phosphoserine45 relationship: transforms_into CCO:B0012484 ! K2C7_HUMAN-Phosphoserine254 relationship: transforms_into CCO:B0012485 ! K2C7_HUMAN-Phosphotyrosine375 relationship: transforms_into CCO:B0012486 ! K2C7_HUMAN-Phosphoserine380 [Term] id: CCO:B0001503 name: DPOLA_HUMAN def: "DNA polymerase alpha catalytic subunit" [UniProtKB:P09884] synonym: "EC 2.7.7.7" EXACT [UniProtKB:P09884] xref: EMBL:AAA52318.1 xref: EMBL:AAP13534.1 xref: EMBL:CAA29920.1 xref: UniProtKB:P09884 xref: UniProtKB:Q86UQ7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004509 ! POLA1_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000278 ! chromatin binding relationship: has_function CCO:F0000406 ! DNA-directed DNA polymerase activity relationship: has_function CCO:F0000407 ! DNA primase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0003351 ! nucleotidyltransferase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000112 ! chromatin relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000253 ! nuclear envelope relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000266 ! alpha DNA polymerase:primase complex relationship: located_in CCO:C0000320 ! nucleolus relationship: located_in CCO:C0000785 ! nuclear matrix relationship: participates_in CCO:I0006337 ! pola-pola2-6 physical interaction relationship: participates_in CCO:I0006338 ! pola-pri1-1 physical interaction relationship: participates_in CCO:I0007308 ! smc1-dpola-1 physical interaction relationship: participates_in CCO:I0007909 ! pol-prim_human physical interaction relationship: participates_in CCO:P0000014 ! S phase of mitotic cell cycle relationship: transforms_into CCO:B0011580 ! DPOLA_HUMAN-Phosphoserine186 [Term] id: CCO:B0001504 name: IL8_HUMAN def: "Interleukin-8 precursor" [UniProtKB:P10145] synonym: "C-X-C motif chemokine 8" EXACT [UniProtKB:P10145] synonym: "Emoctakin" EXACT [UniProtKB:P10145] synonym: "GCP-1" EXACT [UniProtKB:P10145] synonym: "Granulocyte chemotactic protein 1" EXACT [UniProtKB:P10145] synonym: "IL-8" EXACT [UniProtKB:P10145] synonym: "MDNCF" EXACT [UniProtKB:P10145] synonym: "MONAP" EXACT [UniProtKB:P10145] synonym: "Monocyte-derived neutrophil chemotactic factor" EXACT [UniProtKB:P10145] synonym: "Monocyte-derived neutrophil-activating peptide" EXACT [UniProtKB:P10145] synonym: "NAP-1" EXACT [UniProtKB:P10145] synonym: "Neutrophil-activating protein 1" EXACT [UniProtKB:P10145] synonym: "Protein 3-10C" EXACT [UniProtKB:P10145] synonym: "T-cell chemotactic factor" EXACT [UniProtKB:P10145] xref: EMBL:AAA35611.1 xref: EMBL:AAA36323.1 xref: EMBL:AAA59158.1 xref: EMBL:AAH13615.1 xref: EMBL:AAK00048.1 xref: EMBL:AAK60276.1 xref: EMBL:AAP35730.1 xref: EMBL:BAA03245.1 xref: EMBL:CAA68742.1 xref: EMBL:CAA77745.1 xref: EMBL:CAG46948.1 xref: UniProtKB:P10145 xref: UniProtKB:Q6FGF6 xref: UniProtKB:Q6LAE6 xref: UniProtKB:Q96RG6 xref: UniProtKB:Q9C077 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004883 ! IL8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001506 name: BCL2_HUMAN def: "Apoptosis regulator Bcl-2" [UniProtKB:P10415] xref: EMBL:AAA35591.1 xref: EMBL:AAA51813.1 xref: EMBL:AAA51814.1 xref: EMBL:AAD14111.1 xref: EMBL:AAH27258.1 xref: EMBL:AAO26045.1 xref: EMBL:CAA29778.1 xref: UniProtKB:P10415 xref: UniProtKB:P10416 xref: UniProtKB:Q13842 xref: UniProtKB:Q16197 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004151 ! BCL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006207 ! bcl2-bax-2 physical interaction relationship: participates_in CCO:I0007445 ! bax-bcl2-1 physical interaction relationship: transforms_into CCO:B0010773 ! BCL2_HUMAN-Phosphoserine70 [Term] id: CCO:B0001508 name: CD28_HUMAN def: "T-cell-specific surface glycoprotein CD28 precursor" [UniProtKB:P10747] synonym: "TP44" EXACT [UniProtKB:P10747] xref: EMBL:AAA51944.1 xref: EMBL:AAA51945.1 xref: EMBL:AAA60581.1 xref: EMBL:AAF33792.1 xref: EMBL:AAF33793.1 xref: EMBL:AAF33794.1 xref: EMBL:AAH93698.1 xref: EMBL:AAI12086.1 xref: EMBL:AAL40931.1 xref: EMBL:AAY24123.1 xref: EMBL:ABK41938.1 xref: EMBL:CAC29237.1 xref: UniProtKB:P10747 xref: UniProtKB:Q13964 xref: UniProtKB:Q52M23 xref: UniProtKB:Q8NI54 xref: UniProtKB:Q8NI55 xref: UniProtKB:Q8NI56 xref: UniProtKB:Q8WXJ2 xref: UniProtKB:Q9BYV0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004270 ! CD28_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000251 ! positive regulation of mitosis relationship: transforms_into CCO:B0011014 ! CD28_HUMAN-Phosphotyrosine191 relationship: transforms_into CCO:B0011015 ! CD28_HUMAN-Phosphotyrosine209 [Term] id: CCO:B0001510 name: IRF1_HUMAN def: "Interferon regulatory factor 1" [UniProtKB:P10914] synonym: "IRF-1" EXACT [UniProtKB:P10914] xref: EMBL:AAA36043.1 xref: EMBL:AAH09483.1 xref: EMBL:AAV38561.1 xref: EMBL:CAA32624.1 xref: UniProtKB:P10914 xref: UniProtKB:Q96GG7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004903 ! IRF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001512 name: CDK4_HUMAN def: "Cell division protein kinase 4" [UniProtKB:P11802] synonym: "Cyclin-dependent kinase 4" EXACT [UniProtKB:P11802] synonym: "EC 2.7.11.22" EXACT [UniProtKB:P11802] synonym: "PSK-J3" EXACT [UniProtKB:P11802] xref: EMBL:AAA35673.1 xref: EMBL:AAC39521.2 xref: EMBL:AAC50506.1 xref: EMBL:AAD13991.1 xref: EMBL:AAH03644.1 xref: EMBL:AAH05864.1 xref: EMBL:AAH10153.1 xref: EMBL:AAM23014.1 xref: EMBL:CAA88834.1 xref: UniProtKB:O00576 xref: UniProtKB:P11802 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004301 ! CDK4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005779 ! cdk4-cdkn2d physical interaction relationship: participates_in CCO:I0005885 ! c6orf55-cdk4 physical interaction relationship: participates_in CCO:I0005946 ! cdk4-cdkn2b-1 physical interaction relationship: participates_in CCO:I0005957 ! ccnd3-cdk4 physical interaction relationship: participates_in CCO:I0005999 ! cdc37-cdk4 physical interaction relationship: participates_in CCO:I0006058 ! cdknib-cdk4 physical interaction relationship: participates_in CCO:I0006113 ! cdk4-cdkn2a direct interaction relationship: participates_in CCO:I0006129 ! cdk4-ccnd3 direct interaction relationship: participates_in CCO:I0006130 ! mcm2-cdk4 direct interaction relationship: participates_in CCO:I0006134 ! cdk4-ccnd1 direct interaction relationship: participates_in CCO:I0006152 ! cdkn1a-cdk4 direct interaction relationship: participates_in CCO:I0006162 ! cdc7-cdk4 direct interaction relationship: participates_in CCO:I0006525 ! zn655-cdk4-2 physical interaction relationship: participates_in CCO:I0006526 ! zn655-cdk4-3 physical interaction relationship: participates_in CCO:I0006609 ! cdk4-cdc37-1 physical interaction relationship: participates_in CCO:I0006737 ! ccnd2-cdk4-1 physical interaction relationship: participates_in CCO:I0006738 ! ccnd2-cdk4-2 physical interaction relationship: participates_in CCO:I0006862 ! cdk4-ccnd1-5 physical interaction relationship: participates_in CCO:I0007090 ! cdk4-ccnd1-3 physical interaction relationship: participates_in CCO:I0007248 ! cdk4-ccnd1-6 physical interaction relationship: participates_in CCO:I0007392 ! cdk4-cdc37 physical interaction relationship: participates_in CCO:I0007424 ! zn655-cdk4-1 physical interaction relationship: participates_in CCO:I0007544 ! cdk4-ccnd1-1 physical interaction relationship: participates_in CCO:I0007545 ! cdk4-ccnd1-2 physical interaction relationship: participates_in CCO:I0007546 ! cdk4-cdkn1c-1 physical interaction relationship: participates_in CCO:I0007547 ! cdk4-cdkn1b-1 physical interaction relationship: participates_in CCO:I0007548 ! cdk4-cdkn1a-1 physical interaction relationship: participates_in CCO:I0007549 ! cdk4-ccnd3-1 physical interaction relationship: participates_in CCO:I0007550 ! cdk4-ccnd3-2 physical interaction relationship: participates_in CCO:I0007739 ! cdk4-ccnd1-4 physical interaction relationship: participates_in CCO:I0007854 ! cdkn1a-ccnd1-2 physical interaction relationship: participates_in CCO:I0007902 ! cyclind1_cdk4_human direct interaction relationship: participates_in CCO:I0007903 ! cyclind2_cdk4_human direct interaction relationship: participates_in CCO:I0007904 ! cyclind3_cdk4_human direct interaction relationship: participates_in CCO:I0007981 ! cdk4-cdkn2b physical interaction relationship: participates_in CCO:I0008004 ! cdk4-capns1 physical interaction relationship: participates_in CCO:I0008079 ! cdk4-bat3 physical interaction relationship: participates_in CCO:I0008080 ! cdk4-setdb1 physical interaction relationship: participates_in CCO:I0008484 ! mgc3731-cdk4 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011112 ! CDK4_HUMAN-Phosphothreonine172 [Term] id: CCO:B0001513 name: PCNA_HUMAN def: "Proliferating cell nuclear antigen" [UniProtKB:P12004] synonym: "Cyclin" EXACT [UniProtKB:P12004] synonym: "PCNA" EXACT [UniProtKB:P12004] xref: EMBL:AAA35736.1 xref: EMBL:AAA60040.1 xref: EMBL:AAH00491.1 xref: EMBL:AAH62439.1 xref: EMBL:AAM78556.1 xref: EMBL:CAC27344.1 xref: UniProtKB:P12004 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005278 ! PCNA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005962 ! cdkn1a-pcna physical interaction relationship: participates_in CCO:I0005986 ! pcna-pold1-1 physical interaction relationship: participates_in CCO:I0005987 ! pcna-pold1-2 physical interaction [Term] id: CCO:B0001515 name: BMP2_HUMAN def: "Bone morphogenetic protein 2 precursor" [UniProtKB:P12643] synonym: "BMP-2" EXACT [UniProtKB:P12643] synonym: "BMP-2A" EXACT [UniProtKB:P12643] xref: EMBL:AAA51834.1 xref: EMBL:AAF21646.1 xref: EMBL:CAB82007.1 xref: UniProtKB:P12643 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004170 ! BMP2_human relationship: has_function CCO:F0001407 ! receptor binding relationship: has_function CCO:F0001427 ! cytokine activity relationship: has_function CCO:F0001702 ! growth factor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000201 ! extracellular region relationship: located_in CCO:C0000237 ! extracellular space relationship: participates_in CCO:I0006232 ! bmp2-bmpr1a-1 direct interaction relationship: participates_in CCO:I0007709 ! bmp2-bmpr1a-2 direct interaction relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001516 name: BMP4_HUMAN def: "Bone morphogenetic protein 4 precursor" [UniProtKB:P12644] synonym: "BMP-2B" EXACT [UniProtKB:P12644] synonym: "BMP-4" EXACT [UniProtKB:P12644] xref: EMBL:AAA51835.1 xref: EMBL:AAC72278.1 xref: EMBL:AAH20546.1 xref: EMBL:BAA06410.1 xref: UniProtKB:P12644 xref: UniProtKB:Q9UM80 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004171 ! BMP4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001518 name: HGF_HUMAN def: "Hepatocyte growth factor precursor" [UniProtKB:P14210] synonym: "Hepatopoeitin-A" EXACT [UniProtKB:P14210] synonym: "Scatter factor" EXACT [UniProtKB:P14210] synonym: "SF" EXACT [UniProtKB:P14210] xref: EMBL:AAA35980.1 xref: EMBL:AAA52648.1 xref: EMBL:AAA52649.1 xref: EMBL:AAA52650.1 xref: EMBL:AAA64239.1 xref: EMBL:AAA64297.1 xref: EMBL:AAC50539.1 xref: EMBL:AAC71655.1 xref: EMBL:AAG53459.1 xref: EMBL:AAG53460.1 xref: EMBL:AAH22308.1 xref: EMBL:AAH63485.1 xref: EMBL:AAI30285.1 xref: EMBL:AAI30287.1 xref: EMBL:AAO61091.1 xref: EMBL:BAA14348.1 xref: EMBL:CAA34387.1 xref: EMBL:CAA40802.1 xref: EMBL:EAL24189.1 xref: UniProtKB:A1L3U6 xref: UniProtKB:P14210 xref: UniProtKB:Q02935 xref: UniProtKB:Q13494 xref: UniProtKB:Q14519 xref: UniProtKB:Q8TCE2 xref: UniProtKB:Q9BYL9 xref: UniProtKB:Q9BYM0 xref: UniProtKB:Q9UDU6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004803 ! HGF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006236 ! hgf-met-1 direct interaction relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012184 ! HGF_HUMAN-Pyrrolidone carboxylic acid32 [Term] id: CCO:B0001519 name: CCNB1_HUMAN def: "G2/mitotic-specific cyclin-B1" [UniProtKB:P14635] xref: EMBL:AAH06510.1 xref: EMBL:AAP88038.1 xref: UniProtKB:P14635 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004244 ! CCNB1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:I0006292 ! cdkn1b-ccnb1-1 physical interaction relationship: participates_in CCO:I0006861 ! cdc2-ccnb1-1 physical interaction relationship: participates_in CCO:I0007244 ! pkmyt1-ccnb1-1 physical interaction relationship: participates_in CCO:I0007245 ! ccnb1-pkmyt1-1 physical interaction relationship: participates_in CCO:I0007899 ! cyclinb1_cdk1_human direct interaction relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0001520 name: ERF3A_HUMAN def: "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A" [UniProtKB:P15170] synonym: "eRF3a" EXACT [UniProtKB:P15170] synonym: "Eukaryotic peptide chain release factor subunit 3a" EXACT [UniProtKB:P15170] synonym: "G1 to S phase transition protein 1 homolog" EXACT [UniProtKB:P15170] xref: EMBL:AAB67250.1 xref: EMBL:CAA35635.1 xref: UniProtKB:P15170 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004735 ! GSPT1_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000318 ! translation release factor activity relationship: has_function CCO:F0000427 ! GTPase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: participates_in CCO:I0007625 ! atxn1-gspt1 physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle [Term] id: CCO:B0001523 name: PGDH_HUMAN def: "15-hydroxyprostaglandin dehydrogenase [NAD+]" [UniProtKB:P15428] synonym: "EC 1.1.1.141" EXACT [UniProtKB:P15428] synonym: "PGDH" EXACT [UniProtKB:P15428] synonym: "Prostaglandin dehydrogenase 1" EXACT [UniProtKB:P15428] xref: EMBL:AAA89174.1 xref: EMBL:AAA89175.1 xref: EMBL:AAH18986.1 xref: UniProtKB:P15428 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005304 ! HPGD_human relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0001299 ! prostaglandin E receptor activity relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0003127 ! 15-hydroxyprostaglandin dehydrogenase (NAD+) activity relationship: has_function CCO:F0003172 ! oxidoreductase activity relationship: has_function CCO:F0005714 ! protein homodimerization activity relationship: has_function CCO:F0008078 ! NAD binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001524 name: NDKA_HUMAN def: "Nucleoside diphosphate kinase A" [UniProtKB:P15531] synonym: "EC 2.7.4.6" EXACT [UniProtKB:P15531] synonym: "GAAD" EXACT [UniProtKB:P15531] synonym: "Granzyme A-activated DNase" EXACT [UniProtKB:P15531] synonym: "Metastasis inhibition factor nm23" EXACT [UniProtKB:P15531] synonym: "NDK A" EXACT [UniProtKB:P15531] synonym: "NDP kinase A" EXACT [UniProtKB:P15531] synonym: "nm23-H1" EXACT [UniProtKB:P15531] synonym: "Tumor metastatic process-associated protein" EXACT [UniProtKB:P15531] xref: EMBL:AAH00293.1 xref: EMBL:AAH18994.1 xref: EMBL:CAA35621.1 xref: EMBL:CAA51527.1 xref: EMBL:CAA53270.1 xref: UniProtKB:P15531 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005167 ! NME1_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000932 ! deoxyribonuclease activity relationship: has_function CCO:F0000936 ! nucleoside diphosphate kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0005731 ! c8orf32-nme1 physical interaction relationship: participates_in CCO:I0005765 ! nme1-nme4 physical interaction relationship: participates_in CCO:I0005823 ! nme1-polr1c physical interaction relationship: participates_in CCO:I0005832 ! gorasp2-nme1 physical interaction relationship: participates_in CCO:I0005941 ! nme1-nme3 physical interaction relationship: participates_in CCO:I0005955 ! nme1-nme1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001526 name: H2AX_HUMAN def: "Histone H2A.x" [UniProtKB:P16104] synonym: "H2a/x" EXACT [UniProtKB:P16104] xref: EMBL:AAH04915.1 xref: EMBL:AAH11694.1 xref: EMBL:AAH13416.1 xref: EMBL:AAY22178.1 xref: EMBL:CAA32968.1 xref: EMBL:CAG33360.1 xref: UniProtKB:P16104 xref: UniProtKB:Q4ZGJ7 xref: UniProtKB:Q6IAS5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004743 ! H2AFX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006022 ! nbs1-h2afx-2 physical interaction relationship: participates_in CCO:I0006198 ! h2ax-tp53bp1-1 physical interaction relationship: participates_in CCO:I0006514 ! h2afx-nbs1-1 physical interaction relationship: participates_in CCO:I0006515 ! nbs1-h2afx-1 physical interaction relationship: participates_in CCO:I0006517 ! h2afx-mre11a-2 physical interaction relationship: participates_in CCO:I0006518 ! h2afx-nbs1-2 physical interaction relationship: participates_in CCO:I0007342 ! h2afx-nbs1-4 physical interaction relationship: participates_in CCO:I0007538 ! h2afx-nbs1-5 physical interaction relationship: participates_in CCO:I0007850 ! h2afx-mre11a-1 colocalization relationship: participates_in CCO:I0007851 ! h2afx-nbs1-3 physical interaction relationship: participates_in CCO:I0007852 ! h2afx-brca1-1 physical interaction relationship: participates_in CCO:I0008508 ! supt5h-h2afx physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0012008 ! H2AX_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0012009 ! H2AX_HUMAN-Phosphoserine2 relationship: transforms_into CCO:B0012010 ! H2AX_HUMAN-Phosphoserine140 relationship: transforms_into CCO:B0026379 ! H2AX_HUMAN-Phosphothreonine121 [Term] id: CCO:B0001528 name: STMN1_HUMAN def: "Stathmin" [UniProtKB:P16949] synonym: "Leukemia-associated phosphoprotein p18" EXACT [UniProtKB:P16949] synonym: "Metablastin" EXACT [UniProtKB:P16949] synonym: "Oncoprotein 18" EXACT [UniProtKB:P16949] synonym: "Op18" EXACT [UniProtKB:P16949] synonym: "Phosphoprotein p19" EXACT [UniProtKB:P16949] synonym: "pp17" EXACT [UniProtKB:P16949] synonym: "pp19" EXACT [UniProtKB:P16949] synonym: "Prosolin" EXACT [UniProtKB:P16949] synonym: "Protein Pr22" EXACT [UniProtKB:P16949] xref: EMBL:AAA59971.1 xref: EMBL:AAA59980.1 xref: EMBL:AAH82228.1 xref: EMBL:CAA37391.1 xref: EMBL:CAA64398.1 xref: EMBL:CAA77660.1 xref: EMBL:CAC16020.1 xref: UniProtKB:A2A2D1 xref: UniProtKB:P16949 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005696 ! STMN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007611 ! ubqln4-stmn1 physical interaction relationship: participates_in CCO:I0007822 ! stmn1-cdkn1b physical interaction relationship: participates_in CCO:P0000068 ! mitotic spindle organization and biogenesis relationship: transforms_into CCO:B0014258 ! STMN1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0014259 ! STMN1_HUMAN-Phosphoserine16 relationship: transforms_into CCO:B0014260 ! STMN1_HUMAN-Phosphoserine25 relationship: transforms_into CCO:B0014261 ! STMN1_HUMAN-Phosphoserine28 relationship: transforms_into CCO:B0014262 ! STMN1_HUMAN-Phosphoserine38 relationship: transforms_into CCO:B0014263 ! STMN1_HUMAN-Phosphoserine46 relationship: transforms_into CCO:B0014264 ! STMN1_HUMAN-Phosphoserine63 relationship: transforms_into CCO:B0014265 ! STMN1_HUMAN-Phosphothreonine146 [Term] id: CCO:B0001531 name: BMP7_HUMAN def: "Bone morphogenetic protein 7 precursor" [UniProtKB:P18075] synonym: "BMP-7" EXACT [UniProtKB:P18075] synonym: "Eptotermin alfa" EXACT [UniProtKB:P18075] synonym: "OP-1" EXACT [UniProtKB:P18075] synonym: "Osteogenic protein 1" EXACT [UniProtKB:P18075] xref: EMBL:AAA36738.1 xref: EMBL:AAH08584.1 xref: EMBL:CAA36100.1 xref: EMBL:CAB90273.2 xref: EMBL:CAC08434.2 xref: UniProtKB:P18075 xref: UniProtKB:Q9H512 xref: UniProtKB:Q9NTQ7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004172 ! BMP7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005973 ! bmp7-nog-1 direct interaction relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001533 name: RCC1_HUMAN def: "Regulator of chromosome condensation" [UniProtKB:P18754] synonym: "Cell cycle regulatory protein" EXACT [UniProtKB:P18754] synonym: "Chromosome condensation protein 1" EXACT [UniProtKB:P18754] xref: EMBL:AAH07300.1 xref: EMBL:AAH10067.1 xref: EMBL:AAH36903.1 xref: EMBL:AAM21072.1 xref: EMBL:BAA00469.1 xref: EMBL:CAA29496.1 xref: EMBL:CAA31182.1 xref: UniProtKB:P18754 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005456 ! RCC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007154 ! ranbp3-rcc1-1 physical interaction relationship: participates_in CCO:I0007155 ! rcc1-xpo1-1 physical interaction relationship: participates_in CCO:I0007298 ! rcc1-ranbp3-1 physical interaction relationship: participates_in CCO:I0007471 ! ran-rcc1-1 direct interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000068 ! mitotic spindle organization and biogenesis relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000099 ! regulation of mitosis relationship: participates_in CCO:P0000101 ! regulation of S phase of mitotic cell cycle relationship: transforms_into CCO:B0013805 ! RCC1_HUMAN-Phosphoserine11 relationship: transforms_into CCO:B0013806 ! RCC1_HUMAN-Phosphoserine403 relationship: transforms_into CCO:B0013807 ! RCC1_HUMAN-Phosphoserine405 relationship: transforms_into CCO:B0013808 ! RCC1_HUMAN-Phosphoserine406 relationship: transforms_into CCO:B0013809 ! RCC1_HUMAN-Phosphothreonine411 [Term] id: CCO:B0001534 name: DNL1_HUMAN def: "DNA ligase 1" [UniProtKB:P18858] synonym: "DNA ligase I" EXACT [UniProtKB:P18858] synonym: "EC 6.5.1.1" EXACT [UniProtKB:P18858] synonym: "Polydeoxyribonucleotide synthase [ATP] 1" EXACT [UniProtKB:P18858] xref: EMBL:AAA59518.1 xref: EMBL:AAI08319.1 xref: EMBL:AAM77697.1 xref: UniProtKB:P18858 xref: UniProtKB:Q32P23 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004492 ! LIG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008480 ! inpp1-lig1 physical interaction relationship: participates_in CCO:I0008513 ! tubb4-lig1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011553 ! DNL1_HUMAN-Phosphoserine49 relationship: transforms_into CCO:B0011554 ! DNL1_HUMAN-Phosphoserine51 relationship: transforms_into CCO:B0011555 ! DNL1_HUMAN-Phosphoserine66 relationship: transforms_into CCO:B0011556 ! DNL1_HUMAN-Phosphoserine76 relationship: transforms_into CCO:B0011557 ! DNL1_HUMAN-Phosphoserine141 relationship: transforms_into CCO:B0011558 ! DNL1_HUMAN-Phosphothreonine195 relationship: transforms_into CCO:B0011559 ! DNL1_HUMAN-Phosphoserine201 relationship: transforms_into CCO:B0011560 ! DNL1_HUMAN-Phosphoserine230 relationship: transforms_into CCO:B0011561 ! DNL1_HUMAN-Phosphothreonine233 relationship: transforms_into CCO:B0011562 ! DNL1_HUMAN-Phosphoserine911 [Term] id: CCO:B0001535 name: E2AK2_HUMAN def: "Interferon-induced, double-stranded RNA-activated protein kinase" [UniProtKB:P19525] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P19525] synonym: "eIF-2A protein kinase 2" EXACT [UniProtKB:P19525] synonym: "Eukaryotic translation initiation factor 2-alpha kinase 2" EXACT [UniProtKB:P19525] synonym: "Interferon-inducible RNA-dependent protein kinase" EXACT [UniProtKB:P19525] synonym: "P1/eIF-2A protein kinase" EXACT [UniProtKB:P19525] synonym: "p68 kinase" EXACT [UniProtKB:P19525] synonym: "PKR" EXACT [UniProtKB:P19525] synonym: "Protein kinase RNA-activated" EXACT [UniProtKB:P19525] xref: EMBL:AAA18253.1 xref: EMBL:AAA36409.1 xref: EMBL:AAC50768.1 xref: EMBL:AAF13156.1 xref: EMBL:AAH93676.1 xref: EMBL:AAI01476.1 xref: EMBL:AAO38055.1 xref: EMBL:AAY24317.1 xref: UniProtKB:P19525 xref: UniProtKB:Q52M43 xref: UniProtKB:Q9UIR4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004531 ! EIF2AK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011611 ! E2AK2_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0011612 ! E2AK2_HUMAN-Phosphothreonine88 relationship: transforms_into CCO:B0011613 ! E2AK2_HUMAN-Phosphothreonine89 relationship: transforms_into CCO:B0011614 ! E2AK2_HUMAN-Phosphothreonine90 relationship: transforms_into CCO:B0011615 ! E2AK2_HUMAN-Phosphoserine242 relationship: transforms_into CCO:B0011616 ! E2AK2_HUMAN-Phosphothreonine255 relationship: transforms_into CCO:B0011617 ! E2AK2_HUMAN-Phosphothreonine258 relationship: transforms_into CCO:B0011618 ! E2AK2_HUMAN-Phosphothreonine446 relationship: transforms_into CCO:B0011619 ! E2AK2_HUMAN-Phosphothreonine451 [Term] id: CCO:B0001536 name: WT1_HUMAN def: "Wilms tumor protein" [UniProtKB:P19544] synonym: "WT33" EXACT [UniProtKB:P19544] xref: EMBL:AAA36810.1 xref: EMBL:AAA61299.1 xref: EMBL:AAB20110.1 xref: EMBL:AAB20111.1 xref: EMBL:AAB20112.1 xref: EMBL:AAB33443.1 xref: EMBL:AAC60605.1 xref: EMBL:AAH32861.1 xref: EMBL:AAO61088.1 xref: EMBL:CAA35956.1 xref: EMBL:CAA43819.1 xref: EMBL:CAC39220.2 xref: UniProtKB:P19544 xref: UniProtKB:Q15881 xref: UniProtKB:Q16256 xref: UniProtKB:Q16575 xref: UniProtKB:Q8IYZ5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005934 ! WT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001538 name: CCNA2_HUMAN def: "Cyclin-A2" [UniProtKB:P20248] synonym: "Cyclin-A" EXACT [UniProtKB:P20248] xref: EMBL:AAI04784.1 xref: EMBL:AAI04788.1 xref: EMBL:AAM54042.1 xref: EMBL:AAY40969.1 xref: EMBL:CAA35986.1 xref: EMBL:CAA48375.1 xref: EMBL:CAG28620.1 xref: UniProtKB:P20248 xref: UniProtKB:Q2M3U6 xref: UniProtKB:Q4W5P4 xref: UniProtKB:Q6LER8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004243 ! CCNA2_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0006020 ! orc1-cdk2-1 physical interaction relationship: participates_in CCO:I0006021 ! orc1-orc2-1 physical interaction relationship: participates_in CCO:I0006332 ! ccna2_cdk2-1 direct interaction relationship: participates_in CCO:I0006451 ! ccna2-cdk2-10 direct interaction relationship: participates_in CCO:I0006452 ! ccna2-cdk2-11 direct interaction relationship: participates_in CCO:I0006563 ! ccna2-cdk2-2 direct interaction relationship: participates_in CCO:I0006570 ! dtnbp1-ccna2 physical interaction relationship: participates_in CCO:I0006770 ! ccna2-cdk2-3 direct interaction relationship: participates_in CCO:I0006798 ! ccna2-cdk2-8 direct interaction relationship: participates_in CCO:I0006945 ! cdkn1b-abl-2 phosphorylation relationship: participates_in CCO:I0007057 ! cdkn1b-cdk2-2 physical interaction relationship: participates_in CCO:I0007059 ! cdkn1b-ccna1-1 direct interaction relationship: participates_in CCO:I0007323 ! cdkn1b-cdk2-4 physical interaction relationship: participates_in CCO:I0007487 ! cdkn1b-cdk2-1 physical interaction relationship: participates_in CCO:I0007488 ! cdkn1b-cdk2-5 phosphorylation relationship: participates_in CCO:I0007499 ! ccna2-cdk2-4 direct interaction relationship: participates_in CCO:I0007500 ! ccna2-cdk2-5 direct interaction relationship: participates_in CCO:I0007501 ! ccna2-cdk2-6 direct interaction relationship: participates_in CCO:I0007502 ! ccna2-cdk2-7 direct interaction relationship: participates_in CCO:I0007533 ! cdt1-cdk2-1 physical interaction relationship: participates_in CCO:I0007825 ! ccna2-cdk2-1 physical interaction relationship: participates_in CCO:I0007896 ! cyclina2_cdk1_human direct interaction relationship: participates_in CCO:I0007898 ! cyclina2_cdk2_human direct interaction relationship: participates_in CCO:I0007941 ! ccna2-cdk2-9 direct interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000106 ! mitotic cell cycle G2/M transition DNA damage checkpoint [Term] id: CCO:B0001540 name: CD2L1_HUMAN def: "PITSLRE serine/threonine-protein kinase CDC2L1" [UniProtKB:P21127] synonym: "CDK11" EXACT [UniProtKB:P21127] synonym: "Cell division cycle 2-like protein kinase 1" EXACT [UniProtKB:P21127] synonym: "CLK-1" EXACT [UniProtKB:P21127] synonym: "EC 2.7.11.22" EXACT [UniProtKB:P21127] synonym: "Galactosyltransferase-associated protein kinase p58/GTA" EXACT [UniProtKB:P21127] synonym: "p58 CLK-1" EXACT [UniProtKB:P21127] xref: EMBL:AAA19581.1 xref: EMBL:AAA19582.1 xref: EMBL:AAA19583.1 xref: EMBL:AAA19584.1 xref: EMBL:AAA19586.1 xref: EMBL:AAA36406.1 xref: EMBL:AAB59449.1 xref: EMBL:AAC72077.1 xref: EMBL:AAC72078.1 xref: EMBL:AAC72079.1 xref: EMBL:AAC72080.1 xref: EMBL:AAC72081.1 xref: EMBL:AAC72082.1 xref: EMBL:AAC83662.1 xref: EMBL:AAC83663.1 xref: EMBL:AAC83664.1 xref: EMBL:AAC83665.1 xref: EMBL:AAC83666.1 xref: EMBL:AAF36538.1 xref: EMBL:AAH33069.1 xref: UniProtKB:O95265 xref: UniProtKB:P21127 xref: UniProtKB:Q12817 xref: UniProtKB:Q12818 xref: UniProtKB:Q12819 xref: UniProtKB:Q12820 xref: UniProtKB:Q12822 xref: UniProtKB:Q8N530 xref: UniProtKB:Q9NZS5 xref: UniProtKB:Q9UBJ0 xref: UniProtKB:Q9UBQ1 xref: UniProtKB:Q9UBR0 xref: UniProtKB:Q9UNY2 xref: UniProtKB:Q9UP57 xref: UniProtKB:Q9UP58 xref: UniProtKB:Q9UP59 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004273 ! CDC2L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006266 ! cdc2l1-pak1-1 physical interaction relationship: participates_in CCO:I0006667 ! cdc2l1-pak1-ac-vit physical interaction relationship: participates_in CCO:I0007946 ! cdc2l1-pak1-2 physical interaction relationship: participates_in CCO:I0008453 ! cdc2l1-c9orf74 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011018 ! CD2L1_HUMAN-Phosphoserine283 relationship: transforms_into CCO:B0011019 ! CD2L1_HUMAN-Phosphothreonine448 relationship: transforms_into CCO:B0011020 ! CD2L1_HUMAN-Phosphotyrosine449 relationship: transforms_into CCO:B0011021 ! CD2L1_HUMAN-Phosphoserine589 relationship: transforms_into CCO:B0011022 ! CD2L1_HUMAN-Phosphothreonine595 relationship: transforms_into CCO:B0011023 ! CD2L1_HUMAN-Phosphothreonine751 relationship: transforms_into CCO:B0011024 ! CD2L1_HUMAN-Phosphoserine752 [Term] id: CCO:B0001541 name: PTN_HUMAN def: "Pleiotrophin precursor" [UniProtKB:P21246] synonym: "HB-GAM" EXACT [UniProtKB:P21246] synonym: "HBBM" EXACT [UniProtKB:P21246] synonym: "HBGF-8" EXACT [UniProtKB:P21246] synonym: "HBNF-1" EXACT [UniProtKB:P21246] synonym: "Heparin-binding brain mitogen" EXACT [UniProtKB:P21246] synonym: "Heparin-binding growth factor 8" EXACT [UniProtKB:P21246] synonym: "Heparin-binding growth-associated molecule" EXACT [UniProtKB:P21246] synonym: "Heparin-binding neurite outgrowth-promoting factor 1" EXACT [UniProtKB:P21246] synonym: "OSF-1" EXACT [UniProtKB:P21246] synonym: "Osteoblast-specific factor 1" EXACT [UniProtKB:P21246] synonym: "PTN" EXACT [UniProtKB:P21246] xref: EMBL:AAA35961.1 xref: EMBL:AAB24425.1 xref: EMBL:AAB26456.1 xref: EMBL:AAH05916.1 xref: EMBL:BAA14261.1 xref: EMBL:BAA22944.1 xref: EMBL:CAA37121.1 xref: UniProtKB:P21246 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005400 ! PTN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006177 ! bard1-ptn physical interaction relationship: participates_in CCO:I0007988 ! psmd2-ptn physical interaction relationship: participates_in CCO:I0008132 ! mad2l1bp-ptn physical interaction relationship: participates_in CCO:I0008180 ! tp53bp2-ptn physical interaction relationship: participates_in CCO:I0008293 ! pmf1-ptn physical interaction relationship: participates_in CCO:I0008300 ! psmb10-ptn physical interaction relationship: participates_in CCO:I0008506 ! spin-ptn physical interaction [Term] id: CCO:B0001542 name: NF1_HUMAN def: "Neurofibromin" [UniProtKB:P21359] synonym: "Neurofibromatosis-related protein NF-1" EXACT [UniProtKB:P21359] xref: EMBL:AAA18483.1 xref: EMBL:AAA59921.1 xref: EMBL:AAA59922.1 xref: EMBL:AAA59923.1 xref: EMBL:AAA59924.1 xref: EMBL:AAA59925.1 xref: EMBL:AAA59928.1 xref: EMBL:AAA74897.1 xref: EMBL:AAB24636.1 xref: EMBL:AAB48373.1 xref: EMBL:AAB48374.1 xref: EMBL:AAB48375.1 xref: EMBL:AAB48376.1 xref: EMBL:AAB48377.1 xref: EMBL:AAB48378.1 xref: EMBL:AAB48379.1 xref: EMBL:AAB48380.1 xref: EMBL:AAB59558.1 xref: EMBL:AAV50004.1 xref: EMBL:BAA01371.1 xref: EMBL:BAA02150.1 xref: EMBL:CAA69179.1 xref: UniProtKB:O00662 xref: UniProtKB:P21359 xref: UniProtKB:Q14284 xref: UniProtKB:Q14930 xref: UniProtKB:Q9UMK3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005186 ! NF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006248 ! nf1-sdc2 physical interaction relationship: participates_in CCO:I0006249 ! nf1-sdc2-1 physical interaction relationship: participates_in CCO:I0006250 ! nf1-sdc2-3 physical interaction relationship: participates_in CCO:I0006251 ! nf1-sdc2-4 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013159 ! NF1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013160 ! NF1_HUMAN-Phosphoserine864 relationship: transforms_into CCO:B0013161 ! NF1_HUMAN-Phosphoserine2188 relationship: transforms_into CCO:B0013162 ! NF1_HUMAN-Phosphothreonine2514 relationship: transforms_into CCO:B0013163 ! NF1_HUMAN-Phosphoserine2515 relationship: transforms_into CCO:B0026382 ! NF1_HUMAN-Phosphoserine2829 [Term] id: CCO:B0001543 name: TAF1_HUMAN def: "Transcription initiation factor TFIID subunit 1" [UniProtKB:P21675] synonym: "Cell cycle gene 1 protein" EXACT [UniProtKB:P21675] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P21675] synonym: "p250" EXACT [UniProtKB:P21675] synonym: "TAF(II)250" EXACT [UniProtKB:P21675] synonym: "TAFII-250" EXACT [UniProtKB:P21675] synonym: "TAFII250" EXACT [UniProtKB:P21675] synonym: "TBP-associated factor 250 kDa" EXACT [UniProtKB:P21675] synonym: "Transcription initiation factor TFIID 250 kDa subunit" EXACT [UniProtKB:P21675] xref: EMBL:AAT38105.1 xref: EMBL:BAA14374.1 xref: EMBL:BAD92553.1 xref: EMBL:CAA30073.1 xref: EMBL:CAD70490.1 xref: EMBL:CAD70491.3 xref: EMBL:CAD70492.2 xref: EMBL:CAD70493.3 xref: EMBL:CAD87527.2 xref: EMBL:CAD87528.2 xref: EMBL:CAM98557.1 xref: UniProtKB:A5CVD0 xref: UniProtKB:P21675 xref: UniProtKB:Q59FZ3 xref: UniProtKB:Q6IUZ1 xref: UniProtKB:Q70Q86 xref: UniProtKB:Q70Q87 xref: UniProtKB:Q70T00 xref: UniProtKB:Q70T01 xref: UniProtKB:Q70T02 xref: UniProtKB:Q70T03 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005726 ! TAF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006023 ! taf1-gtf2f1-3 physical interaction relationship: participates_in CCO:I0006196 ! rb1-taf1-1 physical interaction relationship: participates_in CCO:I0006199 ! taf1-gtf2f1-1 physical interaction relationship: participates_in CCO:I0006200 ! taf1-gtf2f1-2 physical interaction relationship: participates_in CCO:I0006298 ! tbp-taf1-2 physical interaction relationship: participates_in CCO:I0006714 ! tbp-taf1-1 physical interaction relationship: participates_in CCO:I0006939 ! brms1-taf1 physical interaction relationship: participates_in CCO:I0007678 ! gfi1b-taf1 physical interaction relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014305 ! TAF1_HUMAN-Phosphoserine137 relationship: transforms_into CCO:B0014306 ! TAF1_HUMAN-Phosphoserine307 [Term] id: CCO:B0001546 name: NDKB_HUMAN def: "Nucleoside diphosphate kinase B" [UniProtKB:P22392] synonym: "C-myc purine-binding transcription factor PUF" EXACT [UniProtKB:P22392] synonym: "EC 2.7.4.6" EXACT [UniProtKB:P22392] synonym: "NDK B" EXACT [UniProtKB:P22392] synonym: "NDP kinase B" EXACT [UniProtKB:P22392] synonym: "nm23-H2" EXACT [UniProtKB:P22392] xref: EMBL:AAA36369.1 xref: EMBL:AAA60228.1 xref: EMBL:AAH02476.1 xref: EMBL:CAB37870.1 xref: UniProtKB:P22392 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005168 ! NME2_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0000936 ! nucleoside diphosphate kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000181 ! ruffle relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000935 ! lamellipodium relationship: participates_in CCO:I0008137 ! nme3-nme2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001548 name: TBG1_HUMAN def: "Tubulin gamma-1 chain" [UniProtKB:P23258] synonym: "Gamma-1-tubulin" EXACT [UniProtKB:P23258] synonym: "Gamma-tubulin complex component 1" EXACT [UniProtKB:P23258] synonym: "GCP-1" EXACT [UniProtKB:P23258] xref: EMBL:AAA52620.1 xref: EMBL:AAH00619.1 xref: EMBL:AAV38734.1 xref: UniProtKB:P23258 xref: UniProtKB:Q9BW59 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005740 ! TUBG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006006 ! tubg-mark4-2 physical interaction relationship: participates_in CCO:I0006007 ! tubg-mark4-3 physical interaction relationship: participates_in CCO:I0006723 ! disc1-tubg colocalization relationship: participates_in CCO:I0007067 ! tubg-mark4-1 physical interaction relationship: participates_in CCO:I0007970 ! disc1-tubg-1 physical interaction relationship: participates_in CCO:P0000030 ! meiotic spindle organization and biogenesis [Term] id: CCO:B0001549 name: CRCM_HUMAN def: "Colorectal mutant cancer protein" [UniProtKB:P23508] synonym: "Protein MCC" EXACT [UniProtKB:P23508] xref: EMBL:AAA52069.1 xref: EMBL:AAH09279.1 xref: EMBL:AAH18919.1 xref: UniProtKB:P23508 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004394 ! MCC_human relationship: has_function CCO:F0001226 ! receptor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006375 ! map3k3-mcc physical interaction relationship: participates_in CCO:I0006426 ! nfkbib-mcc physical interaction relationship: participates_in CCO:I0007400 ! mcc-nfkbib physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001550 name: KTHY_HUMAN def: "Thymidylate kinase" [UniProtKB:P23919] synonym: "dTMP kinase" EXACT [UniProtKB:P23919] synonym: "EC 2.7.4.9" EXACT [UniProtKB:P23919] xref: EMBL:AAA21719.1 xref: EMBL:AAH01827.1 xref: EMBL:CAA38528.1 xref: EMBL:CAG46783.1 xref: UniProtKB:P23919 xref: UniProtKB:Q6FGX1 xref: UniProtKB:Q9BUX4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004518 ! DTYMK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001551 name: CCND1_HUMAN def: "G1/S-specific cyclin-D1" [UniProtKB:P24385] synonym: "BCL-1 oncogene" EXACT [UniProtKB:P24385] synonym: "PRAD1 oncogene" EXACT [UniProtKB:P24385] xref: EMBL:AAA36481.1 xref: EMBL:AAA52136.1 xref: EMBL:AAA58392.1 xref: EMBL:AAH00076.1 xref: EMBL:AAH01501.1 xref: EMBL:AAH14078.1 xref: EMBL:AAH23620.1 xref: EMBL:AAH25302.1 xref: EMBL:AAM34300.2 xref: EMBL:AAV38648.1 xref: EMBL:CAA42470.1 xref: EMBL:CAA80558.1 xref: UniProtKB:P24385 xref: UniProtKB:Q6LEF0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004248 ! CCND1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:I0006091 ! orc4l-ccnd1 direct interaction relationship: participates_in CCO:I0006105 ! mcm10-ccnd1 direct interaction relationship: participates_in CCO:I0006134 ! cdk4-ccnd1 direct interaction relationship: participates_in CCO:I0006140 ! cdkn1a-ccnd1 direct interaction relationship: participates_in CCO:I0006143 ! cdk6-ccnd1 direct interaction relationship: participates_in CCO:I0006827 ! ccnd1-cdkn1b-2 physical interaction relationship: participates_in CCO:I0006862 ! cdk4-ccnd1-5 physical interaction relationship: participates_in CCO:I0007090 ! cdk4-ccnd1-3 physical interaction relationship: participates_in CCO:I0007091 ! cdkn1a-ccnd1-1 physical interaction relationship: participates_in CCO:I0007092 ! cdkn1b-ccnd1-2 physical interaction relationship: participates_in CCO:I0007248 ! cdk4-ccnd1-6 physical interaction relationship: participates_in CCO:I0007544 ! cdk4-ccnd1-1 physical interaction relationship: participates_in CCO:I0007545 ! cdk4-ccnd1-2 physical interaction relationship: participates_in CCO:I0007739 ! cdk4-ccnd1-4 physical interaction relationship: participates_in CCO:I0007854 ! cdkn1a-ccnd1-2 physical interaction relationship: participates_in CCO:I0007902 ! cyclind1_cdk4_human direct interaction relationship: participates_in CCO:I0007906 ! cyclind1_cdk6_human direct interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001552 name: GA45A_HUMAN def: "Growth arrest and DNA-damage-inducible protein GADD45 alpha" [UniProtKB:P24522] synonym: "DDIT-1" EXACT [UniProtKB:P24522] synonym: "DNA-damage-inducible transcript 1" EXACT [UniProtKB:P24522] xref: EMBL:AAA35863.1 xref: EMBL:AAA72045.1 xref: EMBL:AAH11757.1 xref: EMBL:AAM88884.1 xref: UniProtKB:P24522 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004674 ! GADD45A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0005729 ! dctn2-gadd45a physical interaction relationship: participates_in CCO:I0007530 ! map3k4-gadd45 physical interaction relationship: participates_in CCO:I0008475 ! ftl-gadd45a physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001554 name: CCNE1_HUMAN def: "G1/S-specific cyclin-E1" [UniProtKB:P24864] xref: EMBL:AAA83269.1 xref: EMBL:AAH35498.1 xref: EMBL:AAM54043.1 xref: EMBL:CAA64687.1 xref: EMBL:CAA64688.1 xref: UniProtKB:P24864 xref: UniProtKB:Q14091 xref: UniProtKB:Q8NFG1 xref: UniProtKB:Q92501 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004251 ! CCNE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005984 ! cdn1b-cdk2-1 physical interaction relationship: participates_in CCO:I0005985 ! cdn1b-cdk2-2 physical interaction relationship: participates_in CCO:I0006201 ! ccne1-nbs1-1 physical interaction relationship: participates_in CCO:I0006202 ! ccne1-mre11a-1 physical interaction relationship: participates_in CCO:I0006290 ! cdkn1a-ccne1-2 physical interaction relationship: participates_in CCO:I0006291 ! cdkn1b-ccne1-1 physical interaction relationship: participates_in CCO:I0006293 ! cdkn1a-ccne1-3 physical interaction relationship: participates_in CCO:I0006295 ! cdk2-ccne1-1 physical interaction relationship: participates_in CCO:I0006297 ! cdkn1a-ccne1-4 physical interaction relationship: participates_in CCO:I0006552 ! cdk2-pin1-3 physical interaction relationship: participates_in CCO:I0006553 ! cdk2-ccne1-3 physical interaction relationship: participates_in CCO:I0006826 ! ccne1-cdkn1b-1 physical interaction relationship: participates_in CCO:I0007247 ! cdk2-ccne1-2 physical interaction relationship: participates_in CCO:I0007349 ! cdkn1a-ccne1-5 physical interaction relationship: participates_in CCO:I0007481 ! cdn1b-cdk2-3 physical interaction relationship: participates_in CCO:I0007484 ! cdn1b-cdk2-4 physical interaction relationship: participates_in CCO:I0007485 ! cdn1b-cdk2-5 physical interaction relationship: participates_in CCO:I0007853 ! cdkn1a-ccne1-6 physical interaction relationship: participates_in CCO:I0007856 ! cdkn1a-ccne1-7 physical interaction relationship: participates_in CCO:I0007907 ! cycline1_cdk2_human direct interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0010992 ! CCNE1_HUMAN-Phosphoserine59 relationship: transforms_into CCO:B0010993 ! CCNE1_HUMAN-Phosphothreonine77 relationship: transforms_into CCO:B0010994 ! CCNE1_HUMAN-Phosphoserine387 relationship: transforms_into CCO:B0010995 ! CCNE1_HUMAN-Phosphothreonine395 relationship: transforms_into CCO:B0010996 ! CCNE1_HUMAN-Phosphoserine399 [Term] id: CCO:B0001555 name: CDK2_HUMAN def: "Cell division protein kinase 2" [UniProtKB:P24941] synonym: "EC 2.7.11.22" EXACT [UniProtKB:P24941] synonym: "p33 protein kinase" EXACT [UniProtKB:P24941] xref: EMBL:AAA35667.1 xref: EMBL:AAH03065.1 xref: EMBL:AAM34794.1 xref: EMBL:AAP35467.1 xref: EMBL:CAA43807.1 xref: EMBL:CAA43985.1 xref: UniProtKB:P24941 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004299 ! CDK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005984 ! cdn1b-cdk2-1 physical interaction relationship: participates_in CCO:I0005985 ! cdn1b-cdk2-2 physical interaction relationship: participates_in CCO:I0006020 ! orc1-cdk2-1 physical interaction relationship: participates_in CCO:I0006027 ! uhrf2-cdk2-1 physical interaction relationship: participates_in CCO:I0006028 ! uhrf2-cdk2-3 physical interaction relationship: participates_in CCO:I0006059 ! cdknib-cdk2 physical interaction relationship: participates_in CCO:I0006127 ! cdk2-ccne2 direct interaction relationship: participates_in CCO:I0006150 ! orc2l-cdk2 direct interaction relationship: participates_in CCO:I0006155 ! cdk2-ccnb2 direct interaction relationship: participates_in CCO:I0006158 ! mcm3-cdk2 direct interaction relationship: participates_in CCO:I0006159 ! cdkn1a-cdk2 direct interaction relationship: participates_in CCO:I0006294 ! cdkn1a-cdk2-1 physical interaction relationship: participates_in CCO:I0006295 ! cdk2-ccne1-1 physical interaction relationship: participates_in CCO:I0006332 ! ccna2_cdk2-1 direct interaction relationship: participates_in CCO:I0006451 ! ccna2-cdk2-10 direct interaction relationship: participates_in CCO:I0006452 ! ccna2-cdk2-11 direct interaction relationship: participates_in CCO:I0006552 ! cdk2-pin1-3 physical interaction relationship: participates_in CCO:I0006553 ! cdk2-ccne1-3 physical interaction relationship: participates_in CCO:I0006563 ! ccna2-cdk2-2 direct interaction relationship: participates_in CCO:I0006566 ! cdk2-cdkn3-1 direct interaction relationship: participates_in CCO:I0006770 ! ccna2-cdk2-3 direct interaction relationship: participates_in CCO:I0006798 ! ccna2-cdk2-8 direct interaction relationship: participates_in CCO:I0006945 ! cdkn1b-abl-2 phosphorylation relationship: participates_in CCO:I0007057 ! cdkn1b-cdk2-2 physical interaction relationship: participates_in CCO:I0007058 ! cdkn1b-cdk2-3 direct interaction relationship: participates_in CCO:I0007120 ! uhrf2-cdk2-4 direct interaction relationship: participates_in CCO:I0007247 ! cdk2-ccne1-2 physical interaction relationship: participates_in CCO:I0007323 ! cdkn1b-cdk2-4 physical interaction relationship: participates_in CCO:I0007350 ! cdk2-rb1-1 phosphorylation relationship: participates_in CCO:I0007351 ! cdk2-rb1-2 phosphorylation relationship: participates_in CCO:I0007419 ! uhrf2-cdk2-2 physical interaction relationship: participates_in CCO:I0007481 ! cdn1b-cdk2-3 physical interaction relationship: participates_in CCO:I0007484 ! cdn1b-cdk2-4 physical interaction relationship: participates_in CCO:I0007485 ! cdn1b-cdk2-5 physical interaction relationship: participates_in CCO:I0007487 ! cdkn1b-cdk2-1 physical interaction relationship: participates_in CCO:I0007488 ! cdkn1b-cdk2-5 phosphorylation relationship: participates_in CCO:I0007499 ! ccna2-cdk2-4 direct interaction relationship: participates_in CCO:I0007500 ! ccna2-cdk2-5 direct interaction relationship: participates_in CCO:I0007501 ! ccna2-cdk2-6 direct interaction relationship: participates_in CCO:I0007502 ! ccna2-cdk2-7 direct interaction relationship: participates_in CCO:I0007533 ! cdt1-cdk2-1 physical interaction relationship: participates_in CCO:I0007825 ! ccna2-cdk2-1 physical interaction relationship: participates_in CCO:I0007853 ! cdkn1a-ccne1-6 physical interaction relationship: participates_in CCO:I0007855 ! cdkn1a-ccna1-1 physical interaction relationship: participates_in CCO:I0007857 ! cdkn1a-cdk2-2 physical interaction relationship: participates_in CCO:I0007897 ! cyclina1_cdk2_human direct interaction relationship: participates_in CCO:I0007898 ! cyclina2_cdk2_human direct interaction relationship: participates_in CCO:I0007901 ! cyclinb3_cdk2_human direct interaction relationship: participates_in CCO:I0007907 ! cycline1_cdk2_human direct interaction relationship: participates_in CCO:I0007908 ! cycline2_cdk2_human direct interaction relationship: participates_in CCO:I0007941 ! ccna2-cdk2-9 direct interaction relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000100 ! traversing start control point of mitotic cell cycle relationship: transforms_into CCO:B0011103 ! CDK2_HUMAN-Phosphothreonine14 relationship: transforms_into CCO:B0011104 ! CDK2_HUMAN-Phosphotyrosine15 relationship: transforms_into CCO:B0011105 ! CDK2_HUMAN-Phosphotyrosine19 relationship: transforms_into CCO:B0011106 ! CDK2_HUMAN-Phosphothreonine160 [Term] id: CCO:B0001556 name: APC_HUMAN def: "Adenomatous polyposis coli protein" [UniProtKB:P25054] synonym: "Deleted in polyposis 2.5" EXACT [UniProtKB:P25054] synonym: "Protein APC" EXACT [UniProtKB:P25054] xref: EMBL:AAA03586.1 xref: EMBL:AAA60353.1 xref: EMBL:AAA60354.1 xref: EMBL:AAB21145.2 xref: UniProtKB:P25054 xref: UniProtKB:Q15162 xref: UniProtKB:Q15163 xref: UniProtKB:Q93042 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004081 ! APC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006260 ! csnk1e-apc phosphorylation relationship: participates_in CCO:I0006540 ! apc-ctbb1-1 physical interaction relationship: participates_in CCO:I0007024 ! apc-ctnnb1-3 direct interaction relationship: participates_in CCO:I0007447 ! apc-ctbb1 physical interaction relationship: participates_in CCO:I0007457 ! eb1-apc-1 physical interaction relationship: participates_in CCO:I0007942 ! apc-ctnnb1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0010567 ! APC_HUMAN-Phosphoserine1038 relationship: transforms_into CCO:B0010568 ! APC_HUMAN-Phosphoserine1180 relationship: transforms_into CCO:B0010569 ! APC_HUMAN-Phosphoserine1371 relationship: transforms_into CCO:B0010570 ! APC_HUMAN-Phosphothreonine1697 relationship: transforms_into CCO:B0010571 ! APC_HUMAN-Phosphoserine1861 relationship: transforms_into CCO:B0010572 ! APC_HUMAN-Phosphoserine1863 relationship: transforms_into CCO:B0010573 ! APC_HUMAN-Phosphoserine1864 relationship: transforms_into CCO:B0010574 ! APC_HUMAN-Phosphoserine2283 relationship: transforms_into CCO:B0010575 ! APC_HUMAN-Phosphoserine2398 relationship: transforms_into CCO:B0010576 ! APC_HUMAN-Phosphoserine2674 relationship: transforms_into CCO:B0010577 ! APC_HUMAN-Phosphoserine2710 [Term] id: CCO:B0001558 name: MCM3_HUMAN def: "DNA replication licensing factor MCM3" [UniProtKB:P25205] synonym: "DNA polymerase alpha holoenzyme-associated protein P1" EXACT [UniProtKB:P25205] synonym: "P1-MCM3" EXACT [UniProtKB:P25205] synonym: "P102 protein" EXACT [UniProtKB:P25205] synonym: "RLF subunit beta" EXACT [UniProtKB:P25205] xref: EMBL:AAH01626.1 xref: EMBL:AAH03509.2 xref: EMBL:AAT27321.1 xref: EMBL:BAA07267.1 xref: EMBL:CAA44078.2 xref: EMBL:CAB75298.1 xref: UniProtKB:P25205 xref: UniProtKB:Q92660 xref: UniProtKB:Q9BTR3 xref: UniProtKB:Q9NUE7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005038 ! MCM3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006078 ! mcm2-mcm3 direct interaction relationship: participates_in CCO:I0006080 ! mcm5-mcm3 direct interaction relationship: participates_in CCO:I0006093 ! mcm3-orc5l direct interaction relationship: participates_in CCO:I0006094 ! mcm3-hscdc5 direct interaction relationship: participates_in CCO:I0006095 ! mcm10-mcm3 direct interaction relationship: participates_in CCO:I0006096 ! orc4l-mcm3 direct interaction relationship: participates_in CCO:I0006146 ! mcm3-cdc7 direct interaction relationship: participates_in CCO:I0006154 ! mcm3-hscdc6 direct interaction relationship: participates_in CCO:I0006158 ! mcm3-cdk2 direct interaction relationship: participates_in CCO:I0006163 ! mcm3-mcm6 direct interaction relationship: participates_in CCO:I0006355 ! nfkbia-mcm3 physical interaction relationship: participates_in CCO:I0006956 ! plk1-mcm3-1 physical interaction relationship: participates_in CCO:I0007539 ! orc2-mcm3-1 physical interaction relationship: participates_in CCO:I0007540 ! mcm3-mcm5-1 physical interaction relationship: participates_in CCO:I0007541 ! mcm3-mcm5-2 physical interaction relationship: participates_in CCO:I0007914 ! mcm2-7_human physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012814 ! MCM3_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0012815 ! MCM3_HUMAN-Phosphoserine535 relationship: transforms_into CCO:B0012816 ! MCM3_HUMAN-Phosphoserine668 relationship: transforms_into CCO:B0012817 ! MCM3_HUMAN-Phosphoserine672 relationship: transforms_into CCO:B0012818 ! MCM3_HUMAN-Phosphothreonine674 relationship: transforms_into CCO:B0012819 ! MCM3_HUMAN-Phosphoserine681 relationship: transforms_into CCO:B0012820 ! MCM3_HUMAN-Phosphoserine704 relationship: transforms_into CCO:B0012821 ! MCM3_HUMAN-Phosphoserine711 relationship: transforms_into CCO:B0012822 ! MCM3_HUMAN-Phosphothreonine713 relationship: transforms_into CCO:B0012823 ! MCM3_HUMAN-Phosphothreonine722 relationship: transforms_into CCO:B0012824 ! MCM3_HUMAN-Phosphoserine728 relationship: transforms_into CCO:B0012825 ! MCM3_HUMAN-Phosphoserine734 [Term] id: CCO:B0001559 name: 1433T_HUMAN def: "14-3-3 protein theta" [UniProtKB:P27348] synonym: "14-3-3 protein T-cell" EXACT [UniProtKB:P27348] synonym: "14-3-3 protein tau" EXACT [UniProtKB:P27348] synonym: "Protein HS1" EXACT [UniProtKB:P27348] xref: EMBL:AAC28640.1 xref: EMBL:AAH01197.1 xref: EMBL:AAH50601.1 xref: EMBL:AAH56867.1 xref: EMBL:AAH93019.1 xref: EMBL:AAV38817.1 xref: EMBL:CAA39840.1 xref: EMBL:CAA40622.1 xref: UniProtKB:P27348 xref: UniProtKB:Q567U5 xref: UniProtKB:Q5TZU8 xref: UniProtKB:Q9UP48 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0003997 ! YWHAQ_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0041106 ! 1433T_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0001560 name: MK03_HUMAN def: "Mitogen-activated protein kinase 3" [UniProtKB:P27361] synonym: "EC 2.7.11.24" EXACT [UniProtKB:P27361] synonym: "ERK-1" EXACT [UniProtKB:P27361] synonym: "ERT2" EXACT [UniProtKB:P27361] synonym: "Extracellular signal-regulated kinase 1" EXACT [UniProtKB:P27361] synonym: "Insulin-stimulated MAP2 kinase" EXACT [UniProtKB:P27361] synonym: "MAP kinase 1" EXACT [UniProtKB:P27361] synonym: "MAPK 1" EXACT [UniProtKB:P27361] synonym: "Microtubule-associated protein 2 kinase" EXACT [UniProtKB:P27361] synonym: "p44-ERK1" EXACT [UniProtKB:P27361] synonym: "p44-MAPK" EXACT [UniProtKB:P27361] xref: EMBL:AAA36142.1 xref: EMBL:AAH13992.1 xref: EMBL:CAA42744.1 xref: EMBL:CAA77754.1 xref: UniProtKB:P27361 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005090 ! MAPK3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006299 ! dapk-erk physical interaction relationship: participates_in CCO:I0006300 ! dapk-erk-3 physical interaction relationship: participates_in CCO:I0006672 ! rps6ka4-mapk3 physical interaction relationship: participates_in CCO:I0006717 ! mapk3-elk1-1 phosphorylation relationship: participates_in CCO:I0007551 ! dapk-erk-2 physical interaction relationship: participates_in CCO:I0007858 ! dapk-erk-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012941 ! MK03_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0012942 ! MK03_HUMAN-Phosphothreonine202 relationship: transforms_into CCO:B0012943 ! MK03_HUMAN-Phosphotyrosine204 [Term] id: CCO:B0001561 name: G0S2_HUMAN def: "Putative lymphocyte G0/G1 switch protein 2" [UniProtKB:P27469] xref: EMBL:AAA58966.1 xref: EMBL:AAB04044.1 xref: EMBL:AAH09694.1 xref: EMBL:CAB40150.1 xref: UniProtKB:P27469 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004668 ! G0S2_human relationship: has_function CCO:F0000272 ! molecular_function relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001562 name: RFA1_HUMAN def: "Replication protein A 70 kDa DNA-binding subunit" [UniProtKB:P27694] synonym: "p70" EXACT [UniProtKB:P27694] synonym: "Replication factor A protein 1" EXACT [UniProtKB:P27694] synonym: "RF-A" EXACT [UniProtKB:P27694] synonym: "RP-A" EXACT [UniProtKB:P27694] synonym: "Single-stranded DNA-binding protein" EXACT [UniProtKB:P27694] xref: EMBL:AAA36584.1 xref: EMBL:AAH18126.1 xref: EMBL:AAS94324.1 xref: EMBL:BAD92969.1 xref: UniProtKB:P27694 xref: UniProtKB:Q59ES9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005469 ! RPA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007581 ! p53-rpa1-8 physical interaction relationship: participates_in CCO:I0007749 ! blm-c9orf76-1 physical interaction relationship: participates_in CCO:I0007762 ! blm-rpa1-1 physical interaction relationship: participates_in CCO:I0007763 ! blm-rpa1-2 physical interaction relationship: transforms_into CCO:B0013822 ! RFA1_HUMAN-Phosphothreonine180 [Term] id: CCO:B0001564 name: DPOD1_HUMAN def: "DNA polymerase delta catalytic subunit" [UniProtKB:P28340] synonym: "DNA polymerase subunit delta p125" EXACT [UniProtKB:P28340] synonym: "EC 2.7.7.7" EXACT [UniProtKB:P28340] xref: EMBL:AAA35768.1 xref: EMBL:AAA58439.1 xref: EMBL:AAH08800.1 xref: EMBL:AAM76971.1 xref: UniProtKB:P28340 xref: UniProtKB:Q8NER3 xref: UniProtKB:Q96H98 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004501 ! POLD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005986 ! pcna-pold1-1 physical interaction relationship: participates_in CCO:I0007289 ! pold1-pold2-4 physical interaction relationship: participates_in CCO:I0007290 ! pold1-pold2-5 physical interaction relationship: participates_in CCO:I0007588 ! pold1-pold2-1 physical interaction relationship: participates_in CCO:I0007589 ! pold1-pold2-3 physical interaction relationship: participates_in CCO:I0007590 ! pold1-pold4-1 direct interaction relationship: participates_in CCO:I0007910 ! pold1-pold2-6 physical interaction relationship: participates_in CCO:I0007911 ! pold1-pold2-7 physical interaction relationship: participates_in CCO:I0007912 ! dpol-delta_human physical interaction relationship: participates_in CCO:I0007968 ! pold1pold2-8 physical interaction relationship: participates_in CCO:I0008295 ! pold1-chgb physical interaction relationship: participates_in CCO:I0008296 ! pold1-kiaa1377 physical interaction relationship: participates_in CCO:P0000014 ! S phase of mitotic cell cycle [Term] id: CCO:B0001565 name: MK01_HUMAN def: "Mitogen-activated protein kinase 1" [UniProtKB:P28482] synonym: "EC 2.7.11.24" EXACT [UniProtKB:P28482] synonym: "ERK-2" EXACT [UniProtKB:P28482] synonym: "ERT1" EXACT [UniProtKB:P28482] synonym: "Extracellular signal-regulated kinase 2" EXACT [UniProtKB:P28482] synonym: "MAP kinase 2" EXACT [UniProtKB:P28482] synonym: "MAPK 2" EXACT [UniProtKB:P28482] synonym: "Mitogen-activated protein kinase 2" EXACT [UniProtKB:P28482] synonym: "p42-MAPK" EXACT [UniProtKB:P28482] xref: EMBL:AAA58459.1 xref: EMBL:AAH17832.1 xref: EMBL:CAA77752.1 xref: EMBL:CAA77753.1 xref: UniProtKB:P28482 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005089 ! MAPK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006556 ! mapk1-dusp1-1 physical interaction relationship: participates_in CCO:I0006557 ! mapk1-dusp1-2 physical interaction relationship: participates_in CCO:I0006718 ! mapk1-elk1-1 phosphorylation relationship: participates_in CCO:I0006901 ! mapk1-dusp1-3 phosphorylation relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012937 ! MK01_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0012938 ! MK01_HUMAN-Phosphothreonine185 relationship: transforms_into CCO:B0012939 ! MK01_HUMAN-Phosphotyrosine187 relationship: transforms_into CCO:B0012940 ! MK01_HUMAN-Phosphothreonine190 [Term] id: CCO:B0001566 name: DUS1_HUMAN def: "Dual specificity protein phosphatase 1" [UniProtKB:P28562] synonym: "Dual specificity protein phosphatase hVH1" EXACT [UniProtKB:P28562] synonym: "EC 3.1.3.16" EXACT [UniProtKB:P28562] synonym: "EC 3.1.3.48" EXACT [UniProtKB:P28562] synonym: "MAP kinase phosphatase 1" EXACT [UniProtKB:P28562] synonym: "MKP-1" EXACT [UniProtKB:P28562] synonym: "Protein-tyrosine phosphatase CL100" EXACT [UniProtKB:P28562] xref: EMBL:AAH22463.1 xref: EMBL:ABB96250.1 xref: EMBL:CAA48338.1 xref: UniProtKB:P28562 xref: UniProtKB:Q2V508 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004521 ! DUSP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006556 ! mapk1-dusp1-1 physical interaction relationship: participates_in CCO:I0006557 ! mapk1-dusp1-2 physical interaction relationship: participates_in CCO:I0006745 ! dusp1-ubiq-1 ubiquitination relationship: participates_in CCO:I0006746 ! dusp1-skp2-1 physical interaction relationship: participates_in CCO:I0006747 ! dusp1-skp2-2 physical interaction relationship: participates_in CCO:I0006901 ! mapk1-dusp1-3 phosphorylation relationship: participates_in CCO:I0007149 ! dusp1-skp2-3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001567 name: RBL1_HUMAN def: "Retinoblastoma-like protein 1" [UniProtKB:P28749] synonym: "107 kDa retinoblastoma-associated protein" EXACT [UniProtKB:P28749] synonym: "p107" EXACT [UniProtKB:P28749] synonym: "PRB1" EXACT [UniProtKB:P28749] xref: EMBL:AAA02489.1 xref: EMBL:AAA36397.1 xref: EMBL:AAD14290.1 xref: EMBL:AAH32247.1 xref: EMBL:CAI95151.1 xref: EMBL:CAI95152.1 xref: EMBL:CAI95177.1 xref: EMBL:CAI95178.1 xref: EMBL:CAI95716.1 xref: EMBL:CAI95717.1 xref: UniProtKB:P28749 xref: UniProtKB:Q4VXA0 xref: UniProtKB:Q8N5K6 xref: UniProtKB:Q9H1L5 xref: UniProtKB:Q9H1M1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005445 ! RBL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013754 ! RBL1_HUMAN-Phosphothreonine332 relationship: transforms_into CCO:B0013755 ! RBL1_HUMAN-Phosphothreonine369 relationship: transforms_into CCO:B0013756 ! RBL1_HUMAN-Phosphothreonine385 relationship: transforms_into CCO:B0013757 ! RBL1_HUMAN-Phosphoserine640 relationship: transforms_into CCO:B0013758 ! RBL1_HUMAN-Phosphoserine650 relationship: transforms_into CCO:B0013759 ! RBL1_HUMAN-Phosphoserine762 relationship: transforms_into CCO:B0013760 ! RBL1_HUMAN-Phosphoserine964 relationship: transforms_into CCO:B0013761 ! RBL1_HUMAN-Phosphoserine975 relationship: transforms_into CCO:B0013762 ! RBL1_HUMAN-Phosphoserine988 relationship: transforms_into CCO:B0013763 ! RBL1_HUMAN-Phosphothreonine997 relationship: transforms_into CCO:B0013764 ! RBL1_HUMAN-Phosphoserine1009 [Term] id: CCO:B0001568 name: EPHB2_HUMAN def: "Ephrin type-B receptor 2 precursor" [UniProtKB:P29323] synonym: "DRT" EXACT [UniProtKB:P29323] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P29323] synonym: "ERK" EXACT [UniProtKB:P29323] synonym: "Receptor protein-tyrosine kinase HEK5" EXACT [UniProtKB:P29323] synonym: "Renal carcinoma antigen NY-REN-47" EXACT [UniProtKB:P29323] synonym: "Tyrosine-protein kinase receptor EPH-3" EXACT [UniProtKB:P29323] synonym: "Tyrosine-protein kinase TYRO5" EXACT [UniProtKB:P29323] xref: EMBL:AAA74244.1 xref: EMBL:AAA99310.1 xref: EMBL:AAB94602.1 xref: EMBL:BAA03537.1 xref: EMBL:BAA06506.1 xref: EMBL:BAA07073.1 xref: EMBL:CAA41981.1 xref: EMBL:CAI16428.1 xref: EMBL:CAI16429.1 xref: EMBL:CAI16430.2 xref: EMBL:CAI22645.1 xref: EMBL:CAI22646.1 xref: EMBL:CAI22647.2 xref: EMBL:CAI22897.1 xref: EMBL:CAI22898.1 xref: EMBL:CAI22899.2 xref: UniProtKB:O43477 xref: UniProtKB:P29323 xref: UniProtKB:Q5T0U6 xref: UniProtKB:Q5T0U7 xref: UniProtKB:Q5T0U8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004574 ! EPHB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011729 ! EPHB2_HUMAN-Phosphotyrosine596 relationship: transforms_into CCO:B0011730 ! EPHB2_HUMAN-Phosphotyrosine602 relationship: transforms_into CCO:B0011731 ! EPHB2_HUMAN-Phosphothreonine775 relationship: transforms_into CCO:B0011732 ! EPHB2_HUMAN-Phosphotyrosine780 relationship: transforms_into CCO:B0011733 ! EPHB2_HUMAN-Phosphotyrosine930 [Term] id: CCO:B0001569 name: SHC1_HUMAN def: "SHC-transforming protein 1" [UniProtKB:P29353] synonym: "SH2 domain protein C1" EXACT [UniProtKB:P29353] synonym: "Src homology 2 domain-containing-transforming protein C1" EXACT [UniProtKB:P29353] xref: EMBL:AAB49972.1 xref: EMBL:AAH14158.1 xref: EMBL:AAH33925.1 xref: EMBL:BAF84832.1 xref: EMBL:BAF98733.1 xref: EMBL:CAA48251.1 xref: EMBL:CAA70977.1 xref: EMBL:CAI13248.1 xref: EMBL:CAI13249.1 xref: EMBL:CAI13250.1 xref: EMBL:CAI13251.1 xref: EMBL:CAI13254.1 xref: EMBL:EAW53168.1 xref: EMBL:EAW53169.1 xref: EMBL:EAW53170.1 xref: UniProtKB:O15290 xref: UniProtKB:P29353 xref: UniProtKB:Q5T180 xref: UniProtKB:Q5T183 xref: UniProtKB:Q5T184 xref: UniProtKB:Q5T185 xref: UniProtKB:Q5T186 xref: UniProtKB:Q8N4K5 xref: UniProtKB:Q96CL1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005610 ! SHC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005792 ! ndp52-shc1 physical interaction relationship: participates_in CCO:I0006285 ! igf1r-shc1-1 physical interaction relationship: participates_in CCO:I0006286 ! insr-shc1-1 physical interaction relationship: participates_in CCO:I0006335 ! sch1-app-3 physical interaction relationship: participates_in CCO:I0006444 ! erbb2-egfr physical interaction relationship: participates_in CCO:I0006445 ! erbb2-egfr-1 physical interaction relationship: participates_in CCO:I0006541 ! shc1-app-2 physical interaction relationship: participates_in CCO:I0006542 ! shc1-app-1 physical interaction relationship: participates_in CCO:I0006629 ! sch1-app-2 physical interaction relationship: participates_in CCO:I0006677 ! grb2-egfr-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007196 ! krt18-shc1-1 colocalization relationship: participates_in CCO:I0007304 ! erbb2-egfr-2 physical interaction relationship: participates_in CCO:I0007305 ! erbb2-egfr-3 physical interaction relationship: participates_in CCO:I0007390 ! sch1-app-4 physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: participates_in CCO:P0000251 ! positive regulation of mitosis relationship: transforms_into CCO:B0014055 ! SHC1_HUMAN-Phosphoserine36 relationship: transforms_into CCO:B0014056 ! SHC1_HUMAN-Phosphoserine139 relationship: transforms_into CCO:B0014057 ! SHC1_HUMAN-Phosphotyrosine349 relationship: transforms_into CCO:B0014058 ! SHC1_HUMAN-Phosphotyrosine350 relationship: transforms_into CCO:B0014059 ! SHC1_HUMAN-Phosphotyrosine427 [Term] id: CCO:B0001570 name: PML_HUMAN def: "Probable transcription factor PML" [UniProtKB:P29590] synonym: "RING finger protein 71" EXACT [UniProtKB:P29590] synonym: "Tripartite motif-containing protein 19" EXACT [UniProtKB:P29590] xref: EMBL:AAA60125.1 xref: EMBL:AAA60351.1 xref: EMBL:AAA60352.1 xref: EMBL:AAA60388.1 xref: EMBL:AAA60390.1 xref: EMBL:AAG50180.1 xref: EMBL:BAB62809.1 xref: EMBL:CAA44841.1 xref: EMBL:CAA46026.1 xref: UniProtKB:P29590 xref: UniProtKB:P29591 xref: UniProtKB:P29592 xref: UniProtKB:P29593 xref: UniProtKB:Q00755 xref: UniProtKB:Q96S41 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005344 ! PML_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006220 ! csnk2a1-pml-1 phosphorylation relationship: participates_in CCO:I0006271 ! pml-ubl_1-1 physical interaction relationship: participates_in CCO:I0006947 ! daxx-pml-2 colocalization relationship: participates_in CCO:I0006990 ! p53-pml-1 physical interaction relationship: participates_in CCO:I0007065 ! pml-daxx-1 physical interaction relationship: participates_in CCO:I0007066 ! daxx-pml-1 physical interaction relationship: participates_in CCO:I0007379 ! csnk2a1-pml phosphorylation relationship: participates_in CCO:P0000065 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest relationship: transforms_into CCO:B0013572 ! PML_HUMAN-Phosphoserine8 relationship: transforms_into CCO:B0013573 ! PML_HUMAN-Phosphoserine403 relationship: transforms_into CCO:B0013574 ! PML_HUMAN-Phosphoserine504 relationship: transforms_into CCO:B0013575 ! PML_HUMAN-Phosphoserine505 relationship: transforms_into CCO:B0013576 ! PML_HUMAN-Phosphoserine512 relationship: transforms_into CCO:B0013577 ! PML_HUMAN-Phosphoserine518 relationship: transforms_into CCO:B0013578 ! PML_HUMAN-Phosphoserine527 relationship: transforms_into CCO:B0013579 ! PML_HUMAN-Phosphoserine530 relationship: transforms_into CCO:B0013580 ! PML_HUMAN-Phosphoserine535 relationship: transforms_into CCO:B0013581 ! PML_HUMAN-Phosphoserine560 relationship: transforms_into CCO:B0013582 ! PML_HUMAN-Phosphoserine561 relationship: transforms_into CCO:B0013583 ! PML_HUMAN-Phosphoserine562 relationship: transforms_into CCO:B0013584 ! PML_HUMAN-Phosphoserine565 [Term] id: CCO:B0001572 name: CDC27_HUMAN def: "Cell division cycle protein 27 homolog" [UniProtKB:P30260] synonym: "CDC27Hs" EXACT [UniProtKB:P30260] synonym: "H-NUC" EXACT [UniProtKB:P30260] xref: EMBL:AAA60471.1 xref: EMBL:AAB34378.1 xref: EMBL:AAH11656.1 xref: EMBL:AAR89911.1 xref: UniProtKB:P30260 xref: UniProtKB:Q16349 xref: UniProtKB:Q96F35 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004287 ! CDC27_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007814 ! cdc27-nek2-1 physical interaction relationship: participates_in CCO:I0007929 ! cdc27-nek2 physical interaction relationship: participates_in CCO:P0000102 ! mitotic metaphase/anaphase transition relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0011068 ! CDC27_HUMAN-Phosphothreonine205 relationship: transforms_into CCO:B0011069 ! CDC27_HUMAN-Phosphothreonine209 relationship: transforms_into CCO:B0011070 ! CDC27_HUMAN-Phosphothreonine244 relationship: transforms_into CCO:B0011071 ! CDC27_HUMAN-Phosphoserine291 relationship: transforms_into CCO:B0011072 ! CDC27_HUMAN-Phosphothreonine313 relationship: transforms_into CCO:B0011073 ! CDC27_HUMAN-Phosphoserine426 relationship: transforms_into CCO:B0011074 ! CDC27_HUMAN-Phosphothreonine430 relationship: transforms_into CCO:B0011075 ! CDC27_HUMAN-Phosphoserine435 relationship: transforms_into CCO:B0011076 ! CDC27_HUMAN-Phosphoserine438 relationship: transforms_into CCO:B0011077 ! CDC27_HUMAN-Phosphothreonine446 [Term] id: CCO:B0001573 name: CCND2_HUMAN def: "G1/S-specific cyclin-D2" [UniProtKB:P30279] xref: EMBL:AAA51926.1 xref: EMBL:AAA51928.1 xref: EMBL:AAH10958.1 xref: EMBL:AAH89384.1 xref: EMBL:AAM54041.1 xref: EMBL:AAV38650.1 xref: EMBL:BAA02802.1 xref: EMBL:CAA48493.1 xref: UniProtKB:P30279 xref: UniProtKB:Q13955 xref: UniProtKB:Q5U035 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004249 ! CCND2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005843 ! ccnd2-cdkn1a physical interaction relationship: participates_in CCO:I0005887 ! ccnd2-cdkn1b physical interaction relationship: participates_in CCO:I0006737 ! ccnd2-cdk4-1 physical interaction relationship: participates_in CCO:I0007903 ! cyclind2_cdk4_human direct interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001574 name: CCND3_HUMAN def: "G1/S-specific cyclin-D3" [UniProtKB:P30281] xref: EMBL:AAA51927.1 xref: EMBL:AAA51929.1 xref: EMBL:AAA52137.1 xref: EMBL:AAH11616.1 xref: EMBL:AAM51826.1 xref: EMBL:CAI23491.1 xref: UniProtKB:P30281 xref: UniProtKB:Q5T8J0 xref: UniProtKB:Q96F49 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004250 ! CCND3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005842 ! ccnd3-dtnbp1 physical interaction relationship: participates_in CCO:I0005845 ! ccnd3-efemp2 physical interaction relationship: participates_in CCO:I0005916 ! ccnd3-maf1 physical interaction relationship: participates_in CCO:I0005944 ! ccnd3-cdkn1b physical interaction relationship: participates_in CCO:I0005956 ! ccnd3-cdkn1a physical interaction relationship: participates_in CCO:I0005957 ! ccnd3-cdk4 physical interaction relationship: participates_in CCO:I0006098 ! mcm10-ccnd3 direct interaction relationship: participates_in CCO:I0006120 ! cdkn1a-ccnd3 direct interaction relationship: participates_in CCO:I0006129 ! cdk4-ccnd3 direct interaction relationship: participates_in CCO:I0006131 ! cdk6-ccnd3 direct interaction relationship: participates_in CCO:I0006738 ! ccnd2-cdk4-2 physical interaction relationship: participates_in CCO:I0007549 ! cdk4-ccnd3-1 physical interaction relationship: participates_in CCO:I0007550 ! cdk4-ccnd3-2 physical interaction relationship: participates_in CCO:I0007904 ! cyclind3_cdk4_human direct interaction relationship: participates_in CCO:I0007905 ! cyclind3_cdk6_human direct interaction relationship: participates_in CCO:I0008194 ! atp5c1-ccnd3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001575 name: WEE1_HUMAN def: "Wee1-like protein kinase" [UniProtKB:P30291] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P30291] synonym: "Wee1A kinase" EXACT [UniProtKB:P30291] synonym: "WEE1hu" EXACT [UniProtKB:P30291] xref: EMBL:AAB60401.1 xref: EMBL:CAA43979.1 xref: EMBL:CAC14173.1 xref: UniProtKB:P30291 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005929 ! WEE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007598 ! skp2-skp1 physical interaction relationship: participates_in CCO:I0007599 ! fbxw11-skp1 physical interaction relationship: participates_in CCO:I0007600 ! btrc-skp1-1 physical interaction relationship: participates_in CCO:I0007601 ! btrc-wee1 physical interaction relationship: participates_in CCO:I0007602 ! fbxw11-wee1 physical interaction relationship: participates_in CCO:I0007915 ! wee1-plk1 phosphorylation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014689 ! WEE1_HUMAN-Phosphoserine123 relationship: transforms_into CCO:B0014690 ! WEE1_HUMAN-Phosphoserine127 relationship: transforms_into CCO:B0014691 ! WEE1_HUMAN-Phosphoserine139 relationship: transforms_into CCO:B0014692 ! WEE1_HUMAN-Phosphoserine165 relationship: transforms_into CCO:B0014693 ! WEE1_HUMAN-Phosphothreonine173 relationship: transforms_into CCO:B0014694 ! WEE1_HUMAN-Phosphoserine642 [Term] id: CCO:B0001576 name: MPIP1_HUMAN def: "M-phase inducer phosphatase 1" [UniProtKB:P30304] synonym: "Dual specificity phosphatase Cdc25A" EXACT [UniProtKB:P30304] synonym: "EC 3.1.3.48" EXACT [UniProtKB:P30304] xref: EMBL:AAA58415.1 xref: EMBL:AAG41884.1 xref: EMBL:AAH07401.1 xref: EMBL:AAH18642.1 xref: EMBL:AAM77917.1 xref: EMBL:AAN11305.1 xref: UniProtKB:P30304 xref: UniProtKB:Q8IZH5 xref: UniProtKB:Q96IL3 xref: UniProtKB:Q9H2F2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005117 ! CDC25A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005818 ! ard1-cdc25a physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012983 ! MPIP1_HUMAN-Phosphoserine76 relationship: transforms_into CCO:B0012984 ! MPIP1_HUMAN-Phosphoserine124 relationship: transforms_into CCO:B0012985 ! MPIP1_HUMAN-Phosphoserine178 relationship: transforms_into CCO:B0012986 ! MPIP1_HUMAN-Phosphoserine279 relationship: transforms_into CCO:B0012987 ! MPIP1_HUMAN-Phosphoserine293 relationship: transforms_into CCO:B0012988 ! MPIP1_HUMAN-Phosphothreonine507 [Term] id: CCO:B0001577 name: MPIP2_HUMAN def: "M-phase inducer phosphatase 2" [UniProtKB:P30305] synonym: "Dual specificity phosphatase Cdc25B" EXACT [UniProtKB:P30305] synonym: "EC 3.1.3.48" EXACT [UniProtKB:P30305] xref: EMBL:AAA58416.1 xref: EMBL:AAB21139.1 xref: EMBL:AAB94622.1 xref: EMBL:AAB94624.1 xref: EMBL:AAH06395.1 xref: EMBL:AAH09953.1 xref: EMBL:AAH51711.1 xref: EMBL:AAR26469.1 xref: EMBL:CAA65303.1 xref: EMBL:CAA92108.1 xref: EMBL:CAC17548.1 xref: EMBL:CAC17549.1 xref: EMBL:CAI18847.1 xref: UniProtKB:O43551 xref: UniProtKB:P30305 xref: UniProtKB:Q13971 xref: UniProtKB:Q5JX77 xref: UniProtKB:Q6RSS1 xref: UniProtKB:Q9BRA6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005118 ! CDC25B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle relationship: participates_in CCO:P0000038 ! mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001578 name: MPIP3_HUMAN def: "M-phase inducer phosphatase 3" [UniProtKB:P30307] synonym: "Dual specificity phosphatase Cdc25C" EXACT [UniProtKB:P30307] synonym: "EC 3.1.3.48" EXACT [UniProtKB:P30307] xref: EMBL:AAA35666.1 xref: EMBL:AAG41885.1 xref: EMBL:AAG41887.1 xref: EMBL:AAG41888.1 xref: EMBL:AAH19089.1 xref: EMBL:AAL26835.1 xref: EMBL:AAR32098.1 xref: EMBL:CAC19192.1 xref: UniProtKB:P30307 xref: UniProtKB:Q96PL3 xref: UniProtKB:Q9H168 xref: UniProtKB:Q9H2E8 xref: UniProtKB:Q9H2E9 xref: UniProtKB:Q9H2F1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005119 ! CDC25C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007377 ! cdc25c-chek1-1 phosphorylation relationship: participates_in CCO:I0007513 ! ppp2r5d-cdc25c-1 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000099 ! regulation of mitosis relationship: participates_in CCO:P0000100 ! traversing start control point of mitotic cell cycle relationship: transforms_into CCO:B0012989 ! MPIP3_HUMAN-Phosphoserine168 relationship: transforms_into CCO:B0012990 ! MPIP3_HUMAN-Phosphoserine216 [Term] id: CCO:B0001580 name: CLIP1_HUMAN def: "CAP-Gly domain-containing linker protein 1" [UniProtKB:P30622] synonym: "CLIP-170" EXACT [UniProtKB:P30622] synonym: "Cytoplasmic linker protein 1" EXACT [UniProtKB:P30622] synonym: "Cytoplasmic linker protein 170 alpha-2" EXACT [UniProtKB:P30622] synonym: "Reed-Sternberg intermediate filament-associated protein" EXACT [UniProtKB:P30622] synonym: "Restin" EXACT [UniProtKB:P30622] xref: EMBL:AAA35693.1 xref: EMBL:CAA46050.1 xref: UniProtKB:P30622 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004370 ! CLIP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011261 ! CLIP1_HUMAN-Phosphothreonine182 relationship: transforms_into CCO:B0011262 ! CLIP1_HUMAN-Phosphoserine195 relationship: transforms_into CCO:B0011263 ! CLIP1_HUMAN-Phosphoserine200 relationship: transforms_into CCO:B0011264 ! CLIP1_HUMAN-Phosphoserine204 relationship: transforms_into CCO:B0035994 ! CLIP1_HUMAN-Phosphothreonine822 [Term] id: CCO:B0001582 name: MK04_HUMAN def: "Mitogen-activated protein kinase 4" [UniProtKB:P31152] synonym: "EC 2.7.11.24" EXACT [UniProtKB:P31152] synonym: "ERK-4" EXACT [UniProtKB:P31152] synonym: "Extracellular signal-regulated kinase 4" EXACT [UniProtKB:P31152] synonym: "MAP kinase isoform p63" EXACT [UniProtKB:P31152] synonym: "p63-MAPK" EXACT [UniProtKB:P31152] xref: EMBL:CAA42411.1 xref: UniProtKB:P31152 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005091 ! MAPK4_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001073 ! MAP kinase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001584 name: 1433S_HUMAN def: "14-3-3 protein sigma" [UniProtKB:P31947] synonym: "Epithelial cell marker protein 1" EXACT [UniProtKB:P31947] synonym: "Stratifin" EXACT [UniProtKB:P31947] xref: EMBL:AAA59546.1 xref: EMBL:AAC52029.1 xref: EMBL:AAC52030.1 xref: EMBL:AAH00329.1 xref: EMBL:AAH00995.1 xref: EMBL:AAH01550.1 xref: EMBL:AAH02995.1 xref: EMBL:AAH23552.1 xref: EMBL:CAA40623.1 xref: EMBL:CAB92118.1 xref: EMBL:CAG46703.1 xref: EMBL:CAG46724.1 xref: UniProtKB:P31947 xref: UniProtKB:Q6FH30 xref: UniProtKB:Q6FH51 xref: UniProtKB:Q96DH0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0003996 ! SFN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006204 ! abl1-snf-1 physical interaction relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0006307 ! abl1-ywhab-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007516 ! egfr-cav1-clca physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0010370 ! 1433S_HUMAN-Phosphoserine64 relationship: transforms_into CCO:B0010371 ! 1433S_HUMAN-Phosphoserine216 relationship: transforms_into CCO:B0010372 ! 1433S_HUMAN-Phosphoserine248 [Term] id: CCO:B0001585 name: TF2H1_HUMAN def: "General transcription factor IIH subunit 1" [UniProtKB:P32780] synonym: "Basic transcription factor 2 62 kDa subunit" EXACT [UniProtKB:P32780] synonym: "BTF2-p62" EXACT [UniProtKB:P32780] synonym: "General transcription factor IIH polypeptide 1" EXACT [UniProtKB:P32780] synonym: "TFIIH basal transcription factor complex p62 subunit" EXACT [UniProtKB:P32780] xref: EMBL:AAA58399.1 xref: EMBL:AAH00365.1 xref: EMBL:AAH04452.1 xref: EMBL:AAN46740.1 xref: EMBL:BAB15621.1 xref: EMBL:CAC00685.1 xref: UniProtKB:P32780 xref: UniProtKB:Q9H5K5 xref: UniProtKB:Q9NQD9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005763 ! GTF2H1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001846 ! RNA polymerase subunit kinase activity relationship: has_function CCO:F0003090 ! general RNA polymerase II transcription factor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000279 ! holo TFIIH complex relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity [Term] id: CCO:B0001586 name: CKS2_HUMAN def: "Cyclin-dependent kinases regulatory subunit 2" [UniProtKB:P33552] synonym: "CKS-2" EXACT [UniProtKB:P33552] xref: EMBL:AAH06458.1 xref: EMBL:AAM22232.1 xref: EMBL:CAA38703.1 xref: UniProtKB:P33552 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004365 ! CKS2_human relationship: has_function CCO:F0003204 ! cyclin-dependent protein kinase regulator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005867 ! cks2-tsc22d4 physical interaction relationship: participates_in CCO:I0008006 ! cks2-eef1a1 physical interaction relationship: participates_in CCO:I0008007 ! cks2-unc119 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001587 name: TTK_HUMAN def: "Dual specificity protein kinase TTK" [UniProtKB:P33981] synonym: "EC 2.7.12.1" EXACT [UniProtKB:P33981] synonym: "Phosphotyrosine picked threonine-protein kinase" EXACT [UniProtKB:P33981] synonym: "PYT" EXACT [UniProtKB:P33981] xref: EMBL:AAA61239.1 xref: EMBL:AAH00633.1 xref: EMBL:AAH32858.1 xref: EMBL:CAA49912.1 xref: EMBL:CAB87580.1 xref: EMBL:EAW48699.1 xref: UniProtKB:P33981 xref: UniProtKB:Q15272 xref: UniProtKB:Q5TCS0 xref: UniProtKB:Q9BW51 xref: UniProtKB:Q9NTM0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005842 ! TTK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000068 ! mitotic spindle organization and biogenesis relationship: participates_in CCO:P0000105 ! mitotic cell cycle spindle assembly checkpoint relationship: transforms_into CCO:B0014553 ! TTK_HUMAN-Phosphoserine821 relationship: transforms_into CCO:B0014554 ! TTK_HUMAN-Phosphoserine824 [Term] id: CCO:B0001588 name: MCM5_HUMAN def: "DNA replication licensing factor MCM5" [UniProtKB:P33992] synonym: "CDC46 homolog" EXACT [UniProtKB:P33992] synonym: "P1-CDC46" EXACT [UniProtKB:P33992] xref: EMBL:AAH00142.1 xref: EMBL:AAH03656.1 xref: EMBL:AAO21127.1 xref: EMBL:BAA12176.1 xref: EMBL:CAA52802.2 xref: EMBL:CAB05110.1 xref: EMBL:CAG30403.1 xref: UniProtKB:O60785 xref: UniProtKB:P33992 xref: UniProtKB:Q14578 xref: UniProtKB:Q9BTJ4 xref: UniProtKB:Q9BWL8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005040 ! MCM5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006080 ! mcm5-mcm3 direct interaction relationship: participates_in CCO:I0006086 ! mcm2-mcm5 direct interaction relationship: participates_in CCO:I0006144 ! mcm7-mcm5 direct interaction relationship: participates_in CCO:I0006151 ! cdkn2a-mcm5 direct interaction relationship: participates_in CCO:I0006540 ! apc-ctbb1-1 physical interaction relationship: participates_in CCO:I0007540 ! mcm3-mcm5-1 physical interaction relationship: participates_in CCO:I0007541 ! mcm3-mcm5-2 physical interaction relationship: participates_in CCO:I0007914 ! mcm2-7_human physical interaction [Term] id: CCO:B0001589 name: MCM7_HUMAN def: "DNA replication licensing factor MCM7" [UniProtKB:P33993] synonym: "CDC47 homolog" EXACT [UniProtKB:P33993] synonym: "P1.1-MCM3" EXACT [UniProtKB:P33993] xref: EMBL:AAH09398.1 xref: EMBL:AAH13375.1 xref: EMBL:BAA05839.1 xref: EMBL:BAA09534.1 xref: EMBL:CAA52803.1 xref: UniProtKB:P33993 xref: UniProtKB:Q15076 xref: UniProtKB:Q96D34 xref: UniProtKB:Q96GL1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005042 ! MCM7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005785 ! mcm7-rbm8a physical interaction relationship: participates_in CCO:I0005858 ! mbip-mcm7 physical interaction relationship: participates_in CCO:I0005964 ! smc1-mcm7-1 physical interaction relationship: participates_in CCO:I0005965 ! smc1-mcm7-3 physical interaction relationship: participates_in CCO:I0005966 ! mcm7-smc1-2 physical interaction relationship: participates_in CCO:I0005968 ! mcm6-mcm7-1 physical interaction relationship: participates_in CCO:I0006079 ! orc4l-mcm7 direct interaction relationship: participates_in CCO:I0006106 ! mcm10-mcm7 direct interaction relationship: participates_in CCO:I0006108 ! mcm2-mcm7 direct interaction relationship: participates_in CCO:I0006109 ! mcm7-orc3l direct interaction relationship: participates_in CCO:I0006126 ! orc6l-mcm7 direct interaction relationship: participates_in CCO:I0006144 ! mcm7-mcm5 direct interaction relationship: participates_in CCO:I0006153 ! mcm4-mcm7 direct interaction relationship: participates_in CCO:I0006227 ! smc1-mcm7-2 physical interaction relationship: participates_in CCO:I0006362 ! ikbkg-mcm7 physical interaction relationship: participates_in CCO:I0006424 ! nfkbia-mcm7 physical interaction relationship: participates_in CCO:I0006705 ! plk1-mcm7-3 physical interaction relationship: participates_in CCO:I0006855 ! plk1-mcm7-1 physical interaction relationship: participates_in CCO:I0006955 ! plk1-mcm7-2 physical interaction relationship: participates_in CCO:I0006957 ! plk1-mcm7-4 physical interaction relationship: participates_in CCO:I0007012 ! smc1-mcm7-4 direct interaction relationship: participates_in CCO:I0007013 ! smc1-mcm7-5 direct interaction relationship: participates_in CCO:I0007306 ! smc1-mcm7-6 physical interaction relationship: participates_in CCO:I0007542 ! mcm4-mcm6-1 physical interaction relationship: participates_in CCO:I0007821 ! mcm7-smc1-1 direct interaction relationship: participates_in CCO:I0007914 ! mcm2-7_human physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012839 ! MCM7_HUMAN-Phosphoserine549 [Term] id: CCO:B0001591 name: PHB_HUMAN def: "Prohibitin" [UniProtKB:P35232] xref: EMBL:AAB21614.1 xref: EMBL:AAH13401.1 xref: EMBL:AAH95460.1 xref: EMBL:AAO18340.1 xref: EMBL:AAP36079.1 xref: UniProtKB:P35232 xref: UniProtKB:Q4VBQ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005306 ! PHB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007380 ! phb-tp53-2 colocalization relationship: participates_in CCO:I0007491 ! phb-tp53-4 colocalization relationship: participates_in CCO:I0007802 ! phb-tp53-1 colocalization relationship: participates_in CCO:I0007924 ! phb-tp53 colocalization relationship: transforms_into CCO:B0013500 ! PHB_HUMAN-Phosphoserine252 relationship: transforms_into CCO:B0013501 ! PHB_HUMAN-Phosphoserine254 relationship: transforms_into CCO:B0031363 ! PHB_HUMAN-Phosphotyrosine249 [Term] id: CCO:B0001592 name: MERL_HUMAN def: "Merlin" [UniProtKB:P35240] synonym: "Moesin-ezrin-radixin-like protein" EXACT [UniProtKB:P35240] synonym: "Neurofibromin-2" EXACT [UniProtKB:P35240] synonym: "Schwannomerlin" EXACT [UniProtKB:P35240] synonym: "Schwannomin" EXACT [UniProtKB:P35240] xref: EMBL:AAA36212.1 xref: EMBL:AAD48752.1 xref: EMBL:AAD48753.1 xref: EMBL:AAD48754.1 xref: EMBL:AAH03112.2 xref: EMBL:AAH20257.1 xref: EMBL:AAK54160.1 xref: EMBL:AAK54161.1 xref: EMBL:AAK54162.1 xref: EMBL:AAK54163.1 xref: EMBL:AAK54164.1 xref: EMBL:AAK54165.1 xref: EMBL:AAK54166.1 xref: EMBL:AAK54195.1 xref: EMBL:AAK54196.1 xref: EMBL:CAA51220.1 xref: EMBL:CAA76992.1 xref: EMBL:CAA76993.1 xref: EMBL:CAA80377.1 xref: EMBL:CAG30416.1 xref: UniProtKB:O95683 xref: UniProtKB:P35240 xref: UniProtKB:Q8WUJ2 xref: UniProtKB:Q969N0 xref: UniProtKB:Q969Q3 xref: UniProtKB:Q96T30 xref: UniProtKB:Q96T31 xref: UniProtKB:Q96T32 xref: UniProtKB:Q96T33 xref: UniProtKB:Q9BTW3 xref: UniProtKB:Q9UNG9 xref: UniProtKB:Q9UNH3 xref: UniProtKB:Q9UNH4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005085 ! NF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0012910 ! MERL_HUMAN-Phosphoserine518 [Term] id: CCO:B0001594 name: DDIT3_HUMAN def: "DNA damage-inducible transcript 3" [UniProtKB:P35638] synonym: "C/EBP-homologous protein" EXACT [UniProtKB:P35638] synonym: "CHOP" EXACT [UniProtKB:P35638] synonym: "DDIT-3" EXACT [UniProtKB:P35638] synonym: "Growth arrest and DNA-damage-inducible protein GADD153" EXACT [UniProtKB:P35638] xref: EMBL:AAB22646.1 xref: EMBL:AAB27103.1 xref: EMBL:AAH03637.1 xref: EMBL:AAW56077.1 xref: UniProtKB:P35638 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004452 ! DDIT3_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0000301 ! transcription corepressor activity relationship: has_function CCO:F0005877 ! sequence-specific DNA binding relationship: has_function CCO:F0006300 ! protein dimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0005744 ! ddit3-dhrs10 physical interaction relationship: participates_in CCO:I0005849 ! c10orf119-ddit3 physical interaction relationship: participates_in CCO:I0005896 ! ddit3-spop physical interaction relationship: participates_in CCO:I0005951 ! batf-ddit3 physical interaction relationship: participates_in CCO:I0005961 ! cebpg-ddit3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001595 name: AHR_HUMAN def: "Aryl hydrocarbon receptor precursor" [UniProtKB:P35869] synonym: "Ah receptor" EXACT [UniProtKB:P35869] synonym: "AhR" EXACT [UniProtKB:P35869] xref: EMBL:AAA16210.1 xref: EMBL:AAA92082.1 xref: EMBL:AAA92083.1 xref: EMBL:AAA92084.1 xref: EMBL:AAH69390.1 xref: EMBL:AAH70080.1 xref: EMBL:BAA03857.1 xref: EMBL:BAA07235.1 xref: UniProtKB:P35869 xref: UniProtKB:Q13728 xref: UniProtKB:Q13803 xref: UniProtKB:Q13804 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004038 ! AHR_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001225 ! signal transducer activity relationship: has_function CCO:F0001226 ! receptor activity relationship: has_function CCO:F0001233 ! ligand-dependent nuclear receptor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0004454 ! transcription regulator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0006062 ! ahr-aip colocalization relationship: participates_in CCO:I0006063 ! ahr-aip-1 colocalization relationship: participates_in CCO:I0006457 ! ahr-rb1 physical interaction relationship: participates_in CCO:I0006458 ! ahr-rb1-1 physical interaction relationship: participates_in CCO:I0006479 ! ahr-arnt-3 physical interaction relationship: participates_in CCO:I0006480 ! ahr-arnt-4 physical interaction relationship: participates_in CCO:I0006544 ! ahr-erap_140-1 physical interaction relationship: participates_in CCO:I0006545 ! ahr-arnt-1 physical interaction relationship: participates_in CCO:I0006546 ! ahr-ncor2-1 physical interaction relationship: participates_in CCO:I0006547 ! ahr-arnt-2 physical interaction relationship: participates_in CCO:I0007813 ! ahr-aip-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001596 name: PP1G_HUMAN def: "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit" [UniProtKB:P36873] synonym: "EC 3.1.3.16" EXACT [UniProtKB:P36873] synonym: "PP-1G" EXACT [UniProtKB:P36873] synonym: "Protein phosphatase 1C catalytic subunit" EXACT [UniProtKB:P36873] xref: EMBL:AAA19823.1 xref: EMBL:AAH14073.1 xref: EMBL:CAA52169.1 xref: UniProtKB:P36873 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005358 ! PPP1CC_human relationship: has_function CCO:F0001086 ! phosphoprotein phosphatase activity relationship: has_function CCO:F0001643 ! iron ion binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0006366 ! ikbkg-ppp1cc physical interaction relationship: participates_in CCO:I0006385 ! map3k3-ppp1cc physical interaction relationship: participates_in CCO:I0006403 ! aah62584-ppp1cc physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001597 name: ACV1B_HUMAN def: "Activin receptor type-1B precursor" [UniProtKB:P36896] synonym: "Activin receptor-like kinase 4" EXACT [UniProtKB:P36896] synonym: "ACTR-IB" EXACT [UniProtKB:P36896] synonym: "ALK-4" EXACT [UniProtKB:P36896] synonym: "EC 2.7.11.30" EXACT [UniProtKB:P36896] synonym: "Serine/threonine-protein kinase receptor R2" EXACT [UniProtKB:P36896] synonym: "SKR2" EXACT [UniProtKB:P36896] xref: EMBL:AAA50246.1 xref: EMBL:AAA53349.1 xref: EMBL:AAA53350.1 xref: EMBL:AAA53351.1 xref: EMBL:AAA60555.1 xref: EMBL:AAA60556.1 xref: EMBL:AAH00254.1 xref: EMBL:AAH40531.1 xref: EMBL:AAP35735.1 xref: EMBL:CAA80258.1 xref: UniProtKB:P36896 xref: UniProtKB:Q15479 xref: UniProtKB:Q15480 xref: UniProtKB:Q15481 xref: UniProtKB:Q15482 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004024 ! ACVR1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: transforms_into CCO:B0010450 ! ACV1B_HUMAN-Phosphotyrosine380 [Term] id: CCO:B0001598 name: BRCA1_HUMAN def: "Breast cancer type 1 susceptibility protein" [UniProtKB:P38398] synonym: "RING finger protein 53" EXACT [UniProtKB:P38398] xref: EMBL:AAA73985.1 xref: EMBL:AAC37594.1 xref: EMBL:AAP12647.1 xref: UniProtKB:P38398 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004186 ! BRCA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006748 ! brca1-trrap-2 physical interaction relationship: participates_in CCO:I0006749 ! brca1-trrap-3 physical interaction relationship: participates_in CCO:I0006772 ! brca1-esr1 physical interaction relationship: participates_in CCO:I0006773 ! esr1-brca1-10 physical interaction relationship: participates_in CCO:I0006774 ! brca1-esr1-2 physical interaction relationship: participates_in CCO:I0006775 ! esr1-brca1-11 physical interaction relationship: participates_in CCO:I0006887 ! brca1-trrap-6 physical interaction relationship: participates_in CCO:I0006914 ! esr1-brca1-5 direct interaction relationship: participates_in CCO:I0006915 ! esr1-brca1-7 direct interaction relationship: participates_in CCO:I0007017 ! brca1-esr1-4 direct interaction relationship: participates_in CCO:I0007018 ! brca1-esr1-5 direct interaction relationship: participates_in CCO:I0007019 ! acaca-brca1-1 physical interaction relationship: participates_in CCO:I0007367 ! trrap-brca1 direct interaction relationship: participates_in CCO:I0007454 ! brca1-trrap physical interaction relationship: participates_in CCO:I0007455 ! brca1-trrap-1 physical interaction relationship: participates_in CCO:I0007492 ! esr1-brca1-1 direct interaction relationship: participates_in CCO:I0007493 ! esr1-brca1-2 direct interaction relationship: participates_in CCO:I0007494 ! esr1-brca1-3 direct interaction relationship: participates_in CCO:I0007495 ! esr1-brca1-6 direct interaction relationship: participates_in CCO:I0007523 ! brap-brca1 physical interaction relationship: participates_in CCO:I0007524 ! brca1-brap physical interaction relationship: participates_in CCO:I0007525 ! kpna2-brca1 physical interaction relationship: participates_in CCO:I0007594 ! brca1-trrap-4 direct interaction relationship: participates_in CCO:I0007595 ! brca1-trrap-5 physical interaction relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction relationship: participates_in CCO:I0007633 ! gfi1b-brca1 physical interaction relationship: participates_in CCO:I0007801 ! acaca-brca1 physical interaction relationship: participates_in CCO:I0007839 ! brca1-brap-2 physical interaction relationship: participates_in CCO:I0007840 ! kpna-bcra1 physical interaction relationship: participates_in CCO:I0007841 ! bcra1-kpna2 physical interaction relationship: participates_in CCO:I0007852 ! h2afx-brca1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: participates_in CCO:P0000273 ! negative regulation of centriole replication relationship: transforms_into CCO:B0010839 ! BRCA1_HUMAN-Phosphoserine840 relationship: transforms_into CCO:B0010840 ! BRCA1_HUMAN-Phosphoserine1143 relationship: transforms_into CCO:B0010841 ! BRCA1_HUMAN-Phosphoserine1211 relationship: transforms_into CCO:B0010842 ! BRCA1_HUMAN-Phosphoserine1212 relationship: transforms_into CCO:B0010843 ! BRCA1_HUMAN-Phosphoserine1217 relationship: transforms_into CCO:B0010844 ! BRCA1_HUMAN-Phosphoserine1218 relationship: transforms_into CCO:B0010845 ! BRCA1_HUMAN-Phosphoserine1239 relationship: transforms_into CCO:B0010846 ! BRCA1_HUMAN-Phosphoserine1245 relationship: transforms_into CCO:B0010847 ! BRCA1_HUMAN-Phosphoserine1280 relationship: transforms_into CCO:B0010848 ! BRCA1_HUMAN-Phosphoserine1330 relationship: transforms_into CCO:B0010849 ! BRCA1_HUMAN-Phosphoserine1336 relationship: transforms_into CCO:B0010850 ! BRCA1_HUMAN-Phosphoserine1342 relationship: transforms_into CCO:B0010851 ! BRCA1_HUMAN-Phosphoserine1387 relationship: transforms_into CCO:B0010852 ! BRCA1_HUMAN-Phosphothreonine1394 relationship: transforms_into CCO:B0010853 ! BRCA1_HUMAN-Phosphoserine1423 relationship: transforms_into CCO:B0010854 ! BRCA1_HUMAN-Phosphoserine1457 relationship: transforms_into CCO:B0010855 ! BRCA1_HUMAN-Phosphoserine1466 relationship: transforms_into CCO:B0010856 ! BRCA1_HUMAN-Phosphoserine1524 relationship: transforms_into CCO:B0010857 ! BRCA1_HUMAN-Phosphothreonine1700 relationship: transforms_into CCO:B0010858 ! BRCA1_HUMAN-Phosphothreonine1720 [Term] id: CCO:B0001599 name: CDN1A_HUMAN def: "Cyclin-dependent kinase inhibitor 1" [UniProtKB:P38936] synonym: "CDK-interacting protein 1" EXACT [UniProtKB:P38936] synonym: "MDA-6" EXACT [UniProtKB:P38936] synonym: "Melanoma differentiation-associated protein 6" EXACT [UniProtKB:P38936] synonym: "p21" EXACT [UniProtKB:P38936] xref: EMBL:AAA16109.1 xref: EMBL:AAA19811.1 xref: EMBL:AAA85641.1 xref: EMBL:AAB29246.1 xref: EMBL:AAB59559.1 xref: EMBL:AAB59560.1 xref: EMBL:AAC04313.1 xref: EMBL:AAH00275.1 xref: EMBL:AAH00312.1 xref: EMBL:AAH01935.1 xref: EMBL:AAH13967.1 xref: EMBL:AAM11787.1 xref: EMBL:CAB06656.1 xref: UniProtKB:P38936 xref: UniProtKB:Q14010 xref: UniProtKB:Q9BUT4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004309 ! CDKN1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005769 ! cdkn1a-tex11 physical interaction relationship: participates_in CCO:I0005843 ! ccnd2-cdkn1a physical interaction relationship: participates_in CCO:I0005956 ! ccnd3-cdkn1a physical interaction relationship: participates_in CCO:I0005962 ! cdkn1a-pcna physical interaction relationship: participates_in CCO:I0006120 ! cdkn1a-ccnd3 direct interaction relationship: participates_in CCO:I0006132 ! cdkn1a-ccne2 direct interaction relationship: participates_in CCO:I0006135 ! cdkn1a-cdc45l direct interaction relationship: participates_in CCO:I0006136 ! cdkn1a-hscdc6 direct interaction relationship: participates_in CCO:I0006137 ! cdkn1a-cdc7 direct interaction relationship: participates_in CCO:I0006140 ! cdkn1a-ccnd1 direct interaction relationship: participates_in CCO:I0006147 ! cdkn1a-hscdc5 direct interaction relationship: participates_in CCO:I0006148 ! cdkn1a-cdk6 direct interaction relationship: participates_in CCO:I0006149 ! cdkn1a-ccnb2 direct interaction relationship: participates_in CCO:I0006152 ! cdkn1a-cdk4 direct interaction relationship: participates_in CCO:I0006156 ! cdkn1a-ccna1 direct interaction relationship: participates_in CCO:I0006159 ! cdkn1a-cdk2 direct interaction relationship: participates_in CCO:I0006160 ! cdkn1a-gmnn direct interaction relationship: participates_in CCO:I0006161 ! cdkn1a-mcm10 direct interaction relationship: participates_in CCO:I0006290 ! cdkn1a-ccne1-2 physical interaction relationship: participates_in CCO:I0006293 ! cdkn1a-ccne1-3 physical interaction relationship: participates_in CCO:I0006294 ! cdkn1a-cdk2-1 physical interaction relationship: participates_in CCO:I0006297 ! cdkn1a-ccne1-4 physical interaction relationship: participates_in CCO:I0006862 ! cdk4-ccnd1-5 physical interaction relationship: participates_in CCO:I0007091 ! cdkn1a-ccnd1-1 physical interaction relationship: participates_in CCO:I0007349 ! cdkn1a-ccne1-5 physical interaction relationship: participates_in CCO:I0007548 ! cdk4-cdkn1a-1 physical interaction relationship: participates_in CCO:I0007853 ! cdkn1a-ccne1-6 physical interaction relationship: participates_in CCO:I0007854 ! cdkn1a-ccnd1-2 physical interaction relationship: participates_in CCO:I0007855 ! cdkn1a-ccna1-1 physical interaction relationship: participates_in CCO:I0007856 ! cdkn1a-ccne1-7 physical interaction relationship: participates_in CCO:I0007857 ! cdkn1a-cdk2-2 physical interaction relationship: participates_in CCO:I0008305 ! rab1a-cdkn1a physical interaction relationship: participates_in CCO:I0008365 ! c7orf20-cdkn1a physical interaction relationship: participates_in CCO:I0008371 ! cdkn1a-gnb2l1 physical interaction relationship: participates_in CCO:I0008372 ! cdkn1a-hdac11 physical interaction relationship: participates_in CCO:I0008456 ! cdkn1a-flj20580 physical interaction relationship: participates_in CCO:I0008457 ! cdkn1a-itgb1bp3 physical interaction relationship: participates_in CCO:I0008458 ! cdkn1a-slc25a11 physical interaction relationship: participates_in CCO:I0008481 ! kiaa0998-cdkn1a physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0011121 ! CDN1A_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0011122 ! CDN1A_HUMAN-Phosphoserine130 relationship: transforms_into CCO:B0011123 ! CDN1A_HUMAN-Phosphothreonine145 relationship: transforms_into CCO:B0011124 ! CDN1A_HUMAN-Phosphoserine146 relationship: transforms_into CCO:B0011125 ! CDN1A_HUMAN-Phosphoserine160 [Term] id: CCO:B0001600 name: VHL_HUMAN def: "Von Hippel-Lindau disease tumor suppressor" [UniProtKB:P40337] synonym: "Protein G7" EXACT [UniProtKB:P40337] synonym: "pVHL" EXACT [UniProtKB:P40337] xref: EMBL:AAA98614.1 xref: EMBL:AAB64200.1 xref: EMBL:CAA65343.1 xref: UniProtKB:P40337 xref: UniProtKB:Q13599 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005902 ! VHL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006820 ! hif1a-vhl-1 physical interaction relationship: participates_in CCO:I0006845 ! tceb1-tceb2-vh1 physical interaction relationship: participates_in CCO:I0007175 ! hif1a-os9-4 direct interaction relationship: participates_in CCO:I0007176 ! hif1a-vhl physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001601 name: MLH1_HUMAN def: "DNA mismatch repair protein Mlh1" [UniProtKB:P40692] synonym: "MutL protein homolog 1" EXACT [UniProtKB:P40692] xref: EMBL:AAA17374.1 xref: EMBL:AAA82079.1 xref: EMBL:AAA85687.1 xref: EMBL:AAC50285.1 xref: EMBL:AAH06850.1 xref: EMBL:AAO22994.1 xref: UniProtKB:P40692 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005100 ! MLH1_human relationship: has_function CCO:F0000288 ! single-stranded DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0004616 ! mismatched DNA binding relationship: has_function CCO:F0004987 ! MutSalpha complex binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0005754 ! ap2b1-mlh1 physical interaction relationship: participates_in CCO:I0005761 ! mlh1-trim29 physical interaction relationship: participates_in CCO:I0005834 ! mlh1-zc3h11a physical interaction relationship: participates_in CCO:I0005854 ! frmd6-mlh1 physical interaction relationship: participates_in CCO:I0005931 ! mlh1-ubox5 physical interaction relationship: participates_in CCO:I0007475 ! pms2-mlh1 direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001602 name: CCNF_HUMAN def: "G2/mitotic-specific cyclin-F" [UniProtKB:P41002] xref: EMBL:AAB60342.1 xref: EMBL:AAH12349.1 xref: EMBL:CAA85308.1 xref: UniProtKB:P41002 xref: UniProtKB:Q96EG9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004253 ! CCNF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001603 name: BCL6_HUMAN def: "B-cell lymphoma 6 protein" [UniProtKB:P41182] synonym: "BCL-5" EXACT [UniProtKB:P41182] synonym: "BCL-6" EXACT [UniProtKB:P41182] synonym: "LAZ-3 protein" EXACT [UniProtKB:P41182] synonym: "Zinc finger and BTB domain-containing protein 27" EXACT [UniProtKB:P41182] synonym: "Zinc finger protein 51" EXACT [UniProtKB:P41182] xref: EMBL:AAC50054.1 xref: EMBL:CAA79937.1 xref: UniProtKB:P41182 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004153 ! BCL6_human relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000278 ! chromatin binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0003206 ! transcription repressor activity relationship: has_function CCO:F0005877 ! sequence-specific DNA binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000265 ! replication fork relationship: participates_in CCO:I0007582 ! bcl6-hdac4 physical interaction relationship: participates_in CCO:I0007583 ! hdac4-bcl6 physical interaction relationship: participates_in CCO:I0007584 ! pkc-bcl6 physical interaction relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: participates_in CCO:P0000244 ! negative regulation of S phase of mitotic cell cycle [Term] id: CCO:B0001604 name: CETN2_HUMAN def: "Centrin-2" [UniProtKB:P41208] synonym: "Caltractin isoform 1" EXACT [UniProtKB:P41208] xref: EMBL:AAH05334.1 xref: EMBL:AAH13873.1 xref: EMBL:AAP35920.1 xref: EMBL:AAW82436.1 xref: EMBL:CAA51467.1 xref: UniProtKB:P41208 xref: UniProtKB:Q53XW1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004333 ! CETN2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011181 ! CETN2_HUMAN-Phosphoserine20 relationship: transforms_into CCO:B0011182 ! CETN2_HUMAN-Phosphothreonine26 [Term] id: CCO:B0001605 name: RGS2_HUMAN def: "Regulator of G-protein signaling 2" [UniProtKB:P41220] synonym: "G0/G1 switch regulatory protein 8" EXACT [UniProtKB:P41220] synonym: "RGS2" EXACT [UniProtKB:P41220] xref: EMBL:AAA20680.1 xref: EMBL:AAC37587.1 xref: EMBL:AAH07049.1 xref: EMBL:AAM12640.1 xref: EMBL:AAP35728.1 xref: EMBL:CAB62512.1 xref: UniProtKB:P41220 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005480 ! RGS2_human relationship: has_function CCO:F0001225 ! signal transducer activity relationship: has_function CCO:F0001401 ! GTPase activator activity relationship: has_function CCO:F0001647 ! calmodulin binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008043 ! rgs2-git1 physical interaction relationship: participates_in CCO:I0008157 ! rgs2-ddr1 physical interaction relationship: participates_in CCO:I0008158 ! rgs2-hspa8 physical interaction relationship: participates_in CCO:I0008309 ! rgs2-arfgap1 physical interaction relationship: participates_in CCO:I0008310 ! rgs2-dncl1 physical interaction relationship: participates_in CCO:I0008311 ! rgs2-park2 physical interaction relationship: participates_in CCO:I0008312 ! rgs2-prkcsh physical interaction relationship: participates_in CCO:I0008427 ! rgs2-wdr74 physical interaction relationship: participates_in CCO:I0008428 ! rgs2-lrfn1 physical interaction relationship: participates_in CCO:I0008429 ! rgs2-nipsnap1 physical interaction relationship: participates_in CCO:I0008430 ! rgs2-vps29 physical interaction relationship: participates_in CCO:I0008496 ! rgs2-ctsb physical interaction relationship: participates_in CCO:I0008497 ! rgs2-scn5a physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001607 name: NBL1_HUMAN def: "Neuroblastoma suppressor of tumorigenicity 1 precursor" [UniProtKB:P41271] synonym: "DAN domain family member 1" EXACT [UniProtKB:P41271] synonym: "N03" EXACT [UniProtKB:P41271] synonym: "Zinc finger protein DAN" EXACT [UniProtKB:P41271] xref: EMBL:AAH12037.1 xref: EMBL:AAL15440.1 xref: EMBL:BAA05671.1 xref: EMBL:BAA92265.1 xref: UniProtKB:P41271 xref: UniProtKB:Q96L68 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005158 ! NBL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000201 ! extracellular region relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001614 name: CNDD3_HUMAN def: "Condensin-2 complex subunit D3" [UniProtKB:P42695] synonym: "hCAP-D3" EXACT [UniProtKB:P42695] synonym: "Non-SMC condensin II complex subunit D3" EXACT [UniProtKB:P42695] xref: EMBL:AAC28639.1 xref: EMBL:AAH98398.1 xref: EMBL:BAA06224.1 xref: EMBL:EAW67824.1 xref: UniProtKB:A6NFS2 xref: UniProtKB:P42695 xref: UniProtKB:Q4KMQ9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004379 ! NCAPD3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: transforms_into CCO:B0011313 ! CNDD3_HUMAN-Phosphoserine531 relationship: transforms_into CCO:B0011314 ! CNDD3_HUMAN-Phosphotyrosine972 relationship: transforms_into CCO:B0011315 ! CNDD3_HUMAN-Phosphoserine1384 relationship: transforms_into CCO:B0011316 ! CNDD3_HUMAN-Phosphoserine1393 relationship: transforms_into CCO:B0035995 ! CNDD3_HUMAN-Phosphoserine1357 [Term] id: CCO:B0001615 name: CD2A1_HUMAN def: "Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3" [UniProtKB:P42771] synonym: "CDK4I" EXACT [UniProtKB:P42771] synonym: "Cyclin-dependent kinase 4 inhibitor A" EXACT [UniProtKB:P42771] synonym: "MTS-1" EXACT [UniProtKB:P42771] synonym: "Multiple tumor suppressor 1" EXACT [UniProtKB:P42771] synonym: "p16-INK4" EXACT [UniProtKB:P42771] synonym: "p16-INK4a" EXACT [UniProtKB:P42771] synonym: "p16INK4A" EXACT [UniProtKB:P42771] xref: EMBL:AAA92554.1 xref: EMBL:AAB60645.1 xref: EMBL:AAD11437.1 xref: EMBL:AAD14048.1 xref: EMBL:AAD14050.1 xref: EMBL:AAH15960.2 xref: EMBL:AAH21998.2 xref: EMBL:AAR05391.1 xref: EMBL:BAB91133.1 xref: EMBL:CAA63870.1 xref: EMBL:CAH70600.1 xref: UniProtKB:O95440 xref: UniProtKB:P42771 xref: UniProtKB:Q15191 xref: UniProtKB:Q5VVJ5 xref: UniProtKB:Q96B52 xref: UniProtKB:Q9NP05 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004271 ! CDKN2A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006112 ! cdk6-cdkn2a direct interaction relationship: participates_in CCO:I0006113 ! cdk4-cdkn2a direct interaction relationship: participates_in CCO:I0006115 ! cdkn2a-gmnn direct interaction relationship: participates_in CCO:I0006117 ! orc4l-cdkn2a direct interaction relationship: participates_in CCO:I0006128 ! cdkn2a-hscdc6 direct interaction relationship: participates_in CCO:I0006133 ! cdkn2a-orc5l direct interaction relationship: participates_in CCO:I0006139 ! cdkn2a-cdc45l direct interaction relationship: participates_in CCO:I0006141 ! cdkn2a-cdc7 direct interaction relationship: participates_in CCO:I0006142 ! mcm2-cdkn2a direct interaction relationship: participates_in CCO:I0006145 ! cdkn2a-mcm10 direct interaction relationship: participates_in CCO:I0006151 ! cdkn2a-mcm5 direct interaction relationship: participates_in CCO:I0006792 ! cdk6-cdkn2a-1 direct interaction relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001616 name: CDN2B_HUMAN def: "Cyclin-dependent kinase 4 inhibitor B" [UniProtKB:P42772] synonym: "MTS-2" EXACT [UniProtKB:P42772] synonym: "Multiple tumor suppressor 2" EXACT [UniProtKB:P42772] synonym: "p14-INK4b" EXACT [UniProtKB:P42772] synonym: "p15-INK4b" EXACT [UniProtKB:P42772] synonym: "p15INK4B" EXACT [UniProtKB:P42772] xref: EMBL:AAA50282.1 xref: EMBL:AAC50075.1 xref: EMBL:AAD14049.1 xref: EMBL:AAH14469.1 xref: EMBL:AAM44859.1 xref: EMBL:CAG38766.1 xref: EMBL:CAH70603.1 xref: UniProtKB:P42772 xref: UniProtKB:Q6FI09 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004312 ! CDKN2B_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005897 ! cdkn2b-magea11 physical interaction relationship: participates_in CCO:I0005946 ! cdk4-cdkn2b-1 physical interaction relationship: participates_in CCO:I0007981 ! cdk4-cdkn2b physical interaction relationship: participates_in CCO:I0008081 ! cdkn2b-kiaa1377 physical interaction relationship: participates_in CCO:I0008191 ! arpc3-cdkn2b physical interaction relationship: participates_in CCO:I0008212 ! cdkn2b-ikbkap physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001617 name: CDN2C_HUMAN def: "Cyclin-dependent kinase 4 inhibitor C" [UniProtKB:P42773] synonym: "Cyclin-dependent kinase 6 inhibitor" EXACT [UniProtKB:P42773] synonym: "p18-INK4c" EXACT [UniProtKB:P42773] synonym: "p18-INK6" EXACT [UniProtKB:P42773] xref: EMBL:AAC39782.1 xref: EMBL:AAC39783.1 xref: EMBL:AAC50074.1 xref: EMBL:AAH00598.1 xref: EMBL:AAH05041.1 xref: EMBL:AAH16173.1 xref: EMBL:AAM11873.1 xref: UniProtKB:P42773 xref: UniProtKB:Q8TB83 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004313 ! CDKN2C_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007982 ! cdkn2c-tp53 physical interaction relationship: participates_in CCO:I0007983 ! cdkn2c-unc119 physical interaction relationship: participates_in CCO:I0008005 ! cdkn2c-rif1 physical interaction relationship: participates_in CCO:I0008026 ! nhp2l1-cdkn2c physical interaction relationship: participates_in CCO:I0008082 ! cdkn2c-dkfzp564o0523 physical interaction relationship: participates_in CCO:I0008083 ! cdkn2c-drap1 physical interaction relationship: participates_in CCO:I0008084 ! cdkn2c-tle1 physical interaction relationship: participates_in CCO:I0008213 ! cdkn2c-aplp1 physical interaction relationship: participates_in CCO:I0008214 ! cdkn2c-cops6 physical interaction relationship: participates_in CCO:I0008215 ! cdkn2c-gdf9 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001618 name: LIS1_HUMAN def: "Platelet-activating factor acetylhydrolase IB subunit alpha" [UniProtKB:P43034] synonym: "LIS-1" EXACT [UniProtKB:P43034] synonym: "Lissencephaly-1 protein" EXACT [UniProtKB:P43034] synonym: "PAF acetylhydrolase 45 kDa subunit" EXACT [UniProtKB:P43034] synonym: "PAF-AH 45 kDa subunit" EXACT [UniProtKB:P43034] synonym: "PAF-AH alpha" EXACT [UniProtKB:P43034] synonym: "PAFAH alpha" EXACT [UniProtKB:P43034] xref: EMBL:AAA02880.1 xref: EMBL:AAA02881.1 xref: EMBL:AAA02882.1 xref: EMBL:AAC51111.1 xref: EMBL:AAH64638.1 xref: EMBL:AAK92483.1 xref: EMBL:AAL34972.1 xref: EMBL:AAL34973.1 xref: EMBL:CAD98141.1 xref: UniProtKB:P43034 xref: UniProtKB:Q8WZ88 xref: UniProtKB:Q8WZ89 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004983 ! PAFAH1B1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006596 ! disc1-pafah1b1 physical interaction relationship: participates_in CCO:I0006597 ! disc1-pafah1b1-1 physical interaction relationship: participates_in CCO:I0007489 ! ndel1_pafah1b1_1 physical interaction relationship: participates_in CCO:I0007490 ! pafah1b1_ndel1_1 physical interaction relationship: participates_in CCO:I0008400 ! kars-pafah1b1 physical interaction relationship: participates_in CCO:P0000028 ! establishment of mitotic spindle orientation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0031335 ! LIS1_HUMAN-Phosphotyrosine28 relationship: transforms_into CCO:B0041156 ! LIS1_HUMAN-Phosphotyrosine225 [Term] id: CCO:B0001619 name: DCC_HUMAN def: "Netrin receptor DCC precursor" [UniProtKB:P43146] synonym: "Colorectal cancer suppressor" EXACT [UniProtKB:P43146] synonym: "Tumor suppressor protein DCC" EXACT [UniProtKB:P43146] xref: EMBL:AAA35751.1 xref: EMBL:AAA52174.1 xref: EMBL:AAA52175.1 xref: EMBL:AAA52176.1 xref: EMBL:AAA52177.1 xref: EMBL:AAA52178.1 xref: EMBL:AAA52179.1 xref: EMBL:AAA52180.1 xref: EMBL:AAA52181.1 xref: EMBL:CAA53735.1 xref: UniProtKB:P43146 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004443 ! DCC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0035997 ! DCC_HUMAN-Phosphoserine1073 relationship: transforms_into CCO:B0035998 ! DCC_HUMAN-Phosphothreonine1074 [Term] id: CCO:B0001620 name: MSH2_HUMAN def: "DNA mismatch repair protein Msh2" [UniProtKB:P43246] synonym: "MutS protein homolog 2" EXACT [UniProtKB:P43246] xref: EMBL:AAA18643.1 xref: EMBL:AAA61870.1 xref: EMBL:AAA76858.1 xref: EMBL:AAA82080.1 xref: EMBL:AAB59564.1 xref: EMBL:AAB59565.1 xref: EMBL:AAC27930.1 xref: EMBL:AAH21566.1 xref: EMBL:AAS99351.1 xref: UniProtKB:O75488 xref: UniProtKB:P43246 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005126 ! MSH2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006361 ! ikbkg-msh2 physical interaction relationship: participates_in CCO:I0006720 ! msh2-msh6-1 physical interaction relationship: participates_in CCO:I0006748 ! brca1-trrap-2 physical interaction relationship: participates_in CCO:I0006749 ! brca1-trrap-3 physical interaction relationship: participates_in CCO:I0006887 ! brca1-trrap-6 physical interaction relationship: participates_in CCO:I0007028 ! msh2-msh3 physical interaction relationship: participates_in CCO:I0007029 ! msh3-msh2-1 physical interaction relationship: participates_in CCO:I0007030 ! msh2-msh6 physical interaction relationship: participates_in CCO:I0007031 ! msh6-msh2 physical interaction relationship: participates_in CCO:I0007032 ! msh2-msh2 physical interaction relationship: participates_in CCO:I0007033 ! msh3-msh2-2 physical interaction relationship: participates_in CCO:I0007034 ! msh6-msh2-1 physical interaction relationship: participates_in CCO:I0007035 ! msh3-msh2-3 physical interaction relationship: participates_in CCO:I0007455 ! brca1-trrap-1 physical interaction relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction relationship: participates_in CCO:I0007838 ! msh2-msh6-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013014 ! MSH2_HUMAN-Phosphoserine860 [Term] id: CCO:B0001621 name: RAD52_HUMAN def: "DNA repair protein RAD52 homolog" [UniProtKB:P43351] xref: EMBL:AAA85793.1 xref: EMBL:AAA87554.1 xref: EMBL:AAB05203.1 xref: EMBL:AAS00097.1 xref: UniProtKB:P43351 xref: UniProtKB:Q13205 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005417 ! RAD52_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006032 ! wrn-rad52-9 colocalization relationship: participates_in CCO:I0007127 ! wrn-rad52-6 physical interaction relationship: participates_in CCO:I0007128 ! wrn-rad52-7 physical interaction relationship: participates_in CCO:I0007436 ! wrn-rad52-1 physical interaction relationship: participates_in CCO:I0007437 ! rad52-rad52-1 physical interaction relationship: participates_in CCO:I0007438 ! rad52-rad51-1 physical interaction relationship: participates_in CCO:I0007439 ! wrn-rad52-2 direct interaction relationship: participates_in CCO:I0007440 ! wrn-rad52-3 direct interaction relationship: participates_in CCO:I0007441 ! wrn-rad52-4 direct interaction relationship: participates_in CCO:I0007442 ! wrn-rad52-5 direct interaction relationship: participates_in CCO:P0000122 ! meiotic recombination relationship: transforms_into CCO:B0013670 ! RAD52_HUMAN-Phosphothreonine318 [Term] id: CCO:B0001622 name: KI67_HUMAN def: "Antigen KI-67" [UniProtKB:P46013] xref: EMBL:CAA46519.1 xref: EMBL:CAA46520.1 xref: EMBL:CAA64388.1 xref: EMBL:CAH73169.1 xref: UniProtKB:P46013 xref: UniProtKB:Q5VWH2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004940 ! MKI67_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006548 ! top1-npm1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012530 ! KI67_HUMAN-Phosphoserine108 relationship: transforms_into CCO:B0012531 ! KI67_HUMAN-Phosphoserine125 relationship: transforms_into CCO:B0012532 ! KI67_HUMAN-Phosphoserine128 relationship: transforms_into CCO:B0012533 ! KI67_HUMAN-Phosphoserine308 relationship: transforms_into CCO:B0012534 ! KI67_HUMAN-Phosphothreonine328 relationship: transforms_into CCO:B0012535 ! KI67_HUMAN-Phosphoserine357 relationship: transforms_into CCO:B0012536 ! KI67_HUMAN-Phosphoserine374 relationship: transforms_into CCO:B0012537 ! KI67_HUMAN-Phosphothreonine543 relationship: transforms_into CCO:B0012538 ! KI67_HUMAN-Phosphoserine579 relationship: transforms_into CCO:B0012539 ! KI67_HUMAN-Phosphoserine584 relationship: transforms_into CCO:B0012540 ! KI67_HUMAN-Phosphoserine648 relationship: transforms_into CCO:B0012541 ! KI67_HUMAN-Phosphoserine1098 relationship: transforms_into CCO:B0012542 ! KI67_HUMAN-Phosphoserine1131 relationship: transforms_into CCO:B0012543 ! KI67_HUMAN-Phosphothreonine1139 relationship: transforms_into CCO:B0012544 ! KI67_HUMAN-Phosphothreonine1193 relationship: transforms_into CCO:B0012545 ! KI67_HUMAN-Phosphoserine1207 relationship: transforms_into CCO:B0012546 ! KI67_HUMAN-Phosphothreonine1233 relationship: transforms_into CCO:B0012547 ! KI67_HUMAN-Phosphoserine1253 relationship: transforms_into CCO:B0012548 ! KI67_HUMAN-Phosphothreonine1298 relationship: transforms_into CCO:B0012549 ! KI67_HUMAN-Phosphoserine1302 relationship: transforms_into CCO:B0012550 ! KI67_HUMAN-Phosphothreonine1327 relationship: transforms_into CCO:B0012551 ! KI67_HUMAN-Phosphothreonine1335 relationship: transforms_into CCO:B0012552 ! KI67_HUMAN-Phosphothreonine1355 relationship: transforms_into CCO:B0012553 ! KI67_HUMAN-Phosphoserine1375 relationship: transforms_into CCO:B0012554 ! KI67_HUMAN-Phosphoserine1376 relationship: transforms_into CCO:B0012555 ! KI67_HUMAN-Phosphothreonine1557 relationship: transforms_into CCO:B0012556 ! KI67_HUMAN-Phosphothreonine1569 relationship: transforms_into CCO:B0012557 ! KI67_HUMAN-Phosphoserine1618 relationship: transforms_into CCO:B0012558 ! KI67_HUMAN-Phosphoserine1629 relationship: transforms_into CCO:B0012559 ! KI67_HUMAN-Phosphoserine1636 relationship: transforms_into CCO:B0012560 ! KI67_HUMAN-Phosphoserine1679 relationship: transforms_into CCO:B0012561 ! KI67_HUMAN-Phosphoserine1740 relationship: transforms_into CCO:B0012562 ! KI67_HUMAN-Phosphothreonine1764 relationship: transforms_into CCO:B0012563 ! KI67_HUMAN-Phosphothreonine1801 relationship: transforms_into CCO:B0012564 ! KI67_HUMAN-Phosphoserine1815 relationship: transforms_into CCO:B0012565 ! KI67_HUMAN-Phosphoserine1861 relationship: transforms_into CCO:B0012566 ! KI67_HUMAN-Phosphothreonine1897 relationship: transforms_into CCO:B0012567 ! KI67_HUMAN-Phosphothreonine1923 relationship: transforms_into CCO:B0012568 ! KI67_HUMAN-Phosphoserine1937 relationship: transforms_into CCO:B0012569 ! KI67_HUMAN-Phosphoserine2002 relationship: transforms_into CCO:B0012570 ! KI67_HUMAN-Phosphothreonine2085 relationship: transforms_into CCO:B0012571 ! KI67_HUMAN-Phosphoserine2105 relationship: transforms_into CCO:B0012572 ! KI67_HUMAN-Phosphoserine2223 relationship: transforms_into CCO:B0012573 ! KI67_HUMAN-Phosphothreonine2231 relationship: transforms_into CCO:B0012574 ! KI67_HUMAN-Phosphothreonine2285 relationship: transforms_into CCO:B0012575 ! KI67_HUMAN-Phosphothreonine2305 relationship: transforms_into CCO:B0012576 ! KI67_HUMAN-Phosphothreonine2406 relationship: transforms_into CCO:B0012577 ! KI67_HUMAN-Phosphoserine2505 relationship: transforms_into CCO:B0012578 ! KI67_HUMAN-Phosphothreonine2508 relationship: transforms_into CCO:B0012579 ! KI67_HUMAN-Phosphoserine2528 relationship: transforms_into CCO:B0012580 ! KI67_HUMAN-Phosphoserine2708 relationship: transforms_into CCO:B0012581 ! KI67_HUMAN-Phosphoserine2827 relationship: transforms_into CCO:B0012582 ! KI67_HUMAN-Phosphoserine2828 relationship: transforms_into CCO:B0036010 ! KI67_HUMAN-Phosphoserine352 [Term] id: CCO:B0001624 name: CDN1B_HUMAN def: "Cyclin-dependent kinase inhibitor 1B" [UniProtKB:P46527] synonym: "Cyclin-dependent kinase inhibitor p27" EXACT [UniProtKB:P46527] synonym: "p27Kip1" EXACT [UniProtKB:P46527] xref: EMBL:AAA20240.1 xref: EMBL:AAD14244.1 xref: EMBL:AAH01971.1 xref: EMBL:AAL78041.1 xref: UniProtKB:P46527 xref: UniProtKB:Q16307 xref: UniProtKB:Q9BUS6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004310 ! CDKN1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005887 ! ccnd2-cdkn1b physical interaction relationship: participates_in CCO:I0005898 ! cdkn1b-traf2 physical interaction relationship: participates_in CCO:I0005944 ! ccnd3-cdkn1b physical interaction relationship: participates_in CCO:I0005984 ! cdn1b-cdk2-1 physical interaction relationship: participates_in CCO:I0005985 ! cdn1b-cdk2-2 physical interaction relationship: participates_in CCO:I0006058 ! cdknib-cdk4 physical interaction relationship: participates_in CCO:I0006059 ! cdknib-cdk2 physical interaction relationship: participates_in CCO:I0006262 ! src-cdn1b-1 phosphorylation relationship: participates_in CCO:I0006263 ! yes-cdn1b-1 phosphorylation relationship: participates_in CCO:I0006291 ! cdkn1b-ccne1-1 physical interaction relationship: participates_in CCO:I0006292 ! cdkn1b-ccnb1-1 physical interaction relationship: participates_in CCO:I0006461 ! cops5-cdkn1b physical interaction relationship: participates_in CCO:I0006462 ! cdkn1b-uchl1 physical interaction relationship: participates_in CCO:I0006826 ! ccne1-cdkn1b-1 physical interaction relationship: participates_in CCO:I0006827 ! ccnd1-cdkn1b-2 physical interaction relationship: participates_in CCO:I0006944 ! cdkn1b-lyn-2 phosphorylation relationship: participates_in CCO:I0006945 ! cdkn1b-abl-2 phosphorylation relationship: participates_in CCO:I0007044 ! cdn1b-cops5 colocalization relationship: participates_in CCO:I0007045 ! cdn1b-uchl1 colocalization relationship: participates_in CCO:I0007057 ! cdkn1b-cdk2-2 physical interaction relationship: participates_in CCO:I0007058 ! cdkn1b-cdk2-3 direct interaction relationship: participates_in CCO:I0007059 ! cdkn1b-ccna1-1 direct interaction relationship: participates_in CCO:I0007092 ! cdkn1b-ccnd1-2 physical interaction relationship: participates_in CCO:I0007253 ! trx-jab1-cdn1b physical interaction relationship: participates_in CCO:I0007323 ! cdkn1b-cdk2-4 physical interaction relationship: participates_in CCO:I0007481 ! cdn1b-cdk2-3 physical interaction relationship: participates_in CCO:I0007484 ! cdn1b-cdk2-4 physical interaction relationship: participates_in CCO:I0007485 ! cdn1b-cdk2-5 physical interaction relationship: participates_in CCO:I0007486 ! cdkn1b-lyn-1 physical interaction relationship: participates_in CCO:I0007487 ! cdkn1b-cdk2-1 physical interaction relationship: participates_in CCO:I0007488 ! cdkn1b-cdk2-5 phosphorylation relationship: participates_in CCO:I0007547 ! cdk4-cdkn1b-1 physical interaction relationship: participates_in CCO:I0007556 ! cdn1b-kpna3-1 physical interaction relationship: participates_in CCO:I0007557 ! cdn1b-kpna3-2 physical interaction relationship: participates_in CCO:I0007558 ! cdn1b-kpna5-1 physical interaction relationship: participates_in CCO:I0007559 ! cdn1b-kpna5-2 physical interaction relationship: participates_in CCO:I0007560 ! cdn1b-kpna5-3 physical interaction relationship: participates_in CCO:I0007741 ! cdn1b-kpna5-4 physical interaction relationship: participates_in CCO:I0007742 ! cdn1b-ywhab-1 physical interaction relationship: participates_in CCO:I0007743 ! cdn1b-ywhae-1 physical interaction relationship: participates_in CCO:I0007744 ! cdn1b-ywhag-1 physical interaction relationship: participates_in CCO:I0007822 ! stmn1-cdkn1b physical interaction relationship: participates_in CCO:I0007825 ! ccna2-cdk2-1 physical interaction relationship: participates_in CCO:I0007861 ! cdn1b-kpna3-3 physical interaction relationship: participates_in CCO:I0007862 ! cdn1b-kpna5-5 physical interaction relationship: participates_in CCO:I0008356 ! arhgdia-cdkn1b physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0011126 ! CDN1B_HUMAN-Phosphoserine10 relationship: transforms_into CCO:B0011127 ! CDN1B_HUMAN-Phosphoserine140 [Term] id: CCO:B0001625 name: PSMD8_HUMAN def: "26S proteasome non-ATPase regulatory subunit 8" [UniProtKB:P48556] synonym: "26S proteasome regulatory subunit S14" EXACT [UniProtKB:P48556] synonym: "p31" EXACT [UniProtKB:P48556] xref: EMBL:AAC62833.1 xref: EMBL:AAH01164.3 xref: EMBL:BAA07237.1 xref: UniProtKB:P48556 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005392 ! PSMD8_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: located_in CCO:C0002079 ! proteasome regulatory particle relationship: participates_in CCO:I0006419 ! traf6-psmd8 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0001626 name: NASP_HUMAN def: "Nuclear autoantigenic sperm protein" [UniProtKB:P49321] synonym: "NASP" EXACT [UniProtKB:P49321] xref: EMBL:AAA36027.1 xref: EMBL:AAH03113.1 xref: EMBL:AAH10105.1 xref: EMBL:AAH11580.1 xref: EMBL:AAH53608.1 xref: EMBL:BAD96536.1 xref: EMBL:CAI22462.1 xref: UniProtKB:P49321 xref: UniProtKB:Q53GW5 xref: UniProtKB:Q5T625 xref: UniProtKB:Q96A69 xref: UniProtKB:Q9BTW2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005156 ! NASP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005783 ! hist1h3a-nasp physical interaction relationship: participates_in CCO:I0005886 ! hist2h3c-nasp physical interaction relationship: participates_in CCO:I0008279 ! nasp-luc7l2 physical interaction relationship: participates_in CCO:I0008350 ! ulk2-nasp physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013091 ! NASP_HUMAN-Phosphoserine189 relationship: transforms_into CCO:B0013092 ! NASP_HUMAN-Phosphothreonine228 relationship: transforms_into CCO:B0013093 ! NASP_HUMAN-Phosphoserine244 relationship: transforms_into CCO:B0013094 ! NASP_HUMAN-Phosphothreonine390 relationship: transforms_into CCO:B0013095 ! NASP_HUMAN-Phosphoserine421 relationship: transforms_into CCO:B0013096 ! NASP_HUMAN-Phosphoserine451 relationship: transforms_into CCO:B0013097 ! NASP_HUMAN-Phosphothreonine464 relationship: transforms_into CCO:B0013098 ! NASP_HUMAN-Phosphothreonine477 relationship: transforms_into CCO:B0013099 ! NASP_HUMAN-Phosphoserine480 relationship: transforms_into CCO:B0013100 ! NASP_HUMAN-Phosphoserine497 relationship: transforms_into CCO:B0013101 ! NASP_HUMAN-Phosphoserine503 relationship: transforms_into CCO:B0013102 ! NASP_HUMAN-Phosphoserine726 [Term] id: CCO:B0001628 name: UB2R1_HUMAN def: "Ubiquitin-conjugating enzyme E2 R1" [UniProtKB:P49427] synonym: "E2-CDC34" EXACT [UniProtKB:P49427] synonym: "EC 6.3.2.19" EXACT [UniProtKB:P49427] synonym: "Ubiquitin-conjugating enzyme E2-32 kDa complementing" EXACT [UniProtKB:P49427] synonym: "Ubiquitin-protein ligase R1" EXACT [UniProtKB:P49427] xref: EMBL:AAC37534.1 xref: EMBL:AAH09850.1 xref: EMBL:AAH18143.1 xref: EMBL:AAH23979.1 xref: EMBL:AAP35305.1 xref: EMBL:AAT46688.1 xref: UniProtKB:P49427 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005853 ! CDC34_human relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003433 ! ligase activity relationship: has_function CCO:F0004170 ! small conjugating protein ligase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0007149 ! dusp1-skp2-3 physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: transforms_into CCO:B0014563 ! UB2R1_HUMAN-Phosphoserine231 [Term] id: CCO:B0001629 name: CENPF_HUMAN def: "Centromere protein F" [UniProtKB:P49454] synonym: "AH antigen" EXACT [UniProtKB:P49454] synonym: "Kinetochore protein CENP-F" EXACT [UniProtKB:P49454] synonym: "Mitosin" EXACT [UniProtKB:P49454] xref: EMBL:AAA82889.1 xref: EMBL:AAA82935.1 xref: EMBL:AAA86889.1 xref: EMBL:CAH71810.1 xref: EMBL:CAH73032.1 xref: UniProtKB:P49454 xref: UniProtKB:Q13171 xref: UniProtKB:Q13246 xref: UniProtKB:Q5VVM7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004325 ! CENPF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006664 ! npm_alk-gak physical interaction relationship: participates_in CCO:I0006665 ! npm_alk-cdc14 physical interaction relationship: participates_in CCO:P0000015 ! G2 phase of mitotic cell cycle relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle relationship: participates_in CCO:P0000038 ! mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000105 ! mitotic cell cycle spindle assembly checkpoint relationship: transforms_into CCO:B0011155 ! CENPF_HUMAN-Phosphoserine268 relationship: transforms_into CCO:B0011156 ! CENPF_HUMAN-Phosphoserine274 relationship: transforms_into CCO:B0011157 ! CENPF_HUMAN-Phosphoserine276 relationship: transforms_into CCO:B0011158 ! CENPF_HUMAN-Phosphoserine821 relationship: transforms_into CCO:B0011159 ! CENPF_HUMAN-Phosphoserine1255 relationship: transforms_into CCO:B0011160 ! CENPF_HUMAN-Phosphoserine1282 relationship: transforms_into CCO:B0011161 ! CENPF_HUMAN-Phosphotyrosine1315 relationship: transforms_into CCO:B0011162 ! CENPF_HUMAN-Phosphothreonine1319 relationship: transforms_into CCO:B0011163 ! CENPF_HUMAN-Phosphoserine1324 relationship: transforms_into CCO:B0011164 ! CENPF_HUMAN-Phosphoserine1747 relationship: transforms_into CCO:B0011165 ! CENPF_HUMAN-Phosphoserine1750 relationship: transforms_into CCO:B0011166 ! CENPF_HUMAN-Phosphoserine1988 relationship: transforms_into CCO:B0011167 ! CENPF_HUMAN-Phosphoserine2513 relationship: transforms_into CCO:B0011168 ! CENPF_HUMAN-Phosphoserine2638 relationship: transforms_into CCO:B0011169 ! CENPF_HUMAN-Phosphoserine2996 relationship: transforms_into CCO:B0011170 ! CENPF_HUMAN-Phosphoserine3007 relationship: transforms_into CCO:B0011171 ! CENPF_HUMAN-Phosphoserine3094 relationship: transforms_into CCO:B0011172 ! CENPF_HUMAN-Phosphoserine3119 relationship: transforms_into CCO:B0011173 ! CENPF_HUMAN-Phosphoserine3150 relationship: transforms_into CCO:B0011174 ! CENPF_HUMAN-Phosphoserine3175 relationship: transforms_into CCO:B0011175 ! CENPF_HUMAN-Phosphoserine3179 [Term] id: CCO:B0001630 name: CTCF_HUMAN def: "Transcriptional repressor CTCF" [UniProtKB:P49711] synonym: "11-zinc finger protein" EXACT [UniProtKB:P49711] synonym: "CCCTC-binding factor" EXACT [UniProtKB:P49711] synonym: "CTCFL paralog" EXACT [UniProtKB:P49711] xref: EMBL:AAB07788.1 xref: EMBL:AAF31318.1 xref: EMBL:AAH14267.1 xref: UniProtKB:P49711 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004414 ! CTCF_human relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0000291 ! RNA polymerase II transcription factor activity relationship: has_function CCO:F0000301 ! transcription corepressor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0005977 ! hspb9-ctcf physical interaction relationship: participates_in CCO:I0006247 ! ctcf-chd8-5 colocalization relationship: participates_in CCO:I0006781 ! ctcf-chd8-3 physical interaction relationship: participates_in CCO:I0006782 ! ctcf-chd8-4 colocalization relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011364 ! CTCF_HUMAN-Phosphoserine609 relationship: transforms_into CCO:B0011365 ! CTCF_HUMAN-Phosphoserine610 relationship: transforms_into CCO:B0011366 ! CTCF_HUMAN-Phosphoserine612 [Term] id: CCO:B0001631 name: MCM2_HUMAN def: "DNA replication licensing factor MCM2" [UniProtKB:P49736] synonym: "Minichromosome maintenance protein 2 homolog" EXACT [UniProtKB:P49736] synonym: "Nuclear protein BM28" EXACT [UniProtKB:P49736] xref: EMBL:AAH06165.3 xref: EMBL:AAH07670.2 xref: EMBL:AAH07938.2 xref: EMBL:AAH14272.2 xref: EMBL:AAH17258.2 xref: EMBL:AAH17490.2 xref: EMBL:AAH30131.2 xref: EMBL:AAP88736.1 xref: EMBL:AAT70723.1 xref: EMBL:BAA04642.1 xref: EMBL:BAA12177.1 xref: EMBL:CAA47749.1 xref: UniProtKB:P49736 xref: UniProtKB:Q14577 xref: UniProtKB:Q15023 xref: UniProtKB:Q8N2V1 xref: UniProtKB:Q969W7 xref: UniProtKB:Q96AE1 xref: UniProtKB:Q9BRM7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005037 ! MCM2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005949 ! mcm2-mcm6 physical interaction relationship: participates_in CCO:I0006074 ! mcm2-orc6l direct interaction relationship: participates_in CCO:I0006078 ! mcm2-mcm3 direct interaction relationship: participates_in CCO:I0006083 ! mcm10-mcm2 direct interaction relationship: participates_in CCO:I0006084 ! mcm2-orc2l direct interaction relationship: participates_in CCO:I0006086 ! mcm2-mcm5 direct interaction relationship: participates_in CCO:I0006089 ! mcm2-cdk6 direct interaction relationship: participates_in CCO:I0006102 ! mcm2-ccnb2 direct interaction relationship: participates_in CCO:I0006108 ! mcm2-mcm7 direct interaction relationship: participates_in CCO:I0006110 ! mcm2-orc5l direct interaction relationship: participates_in CCO:I0006111 ! mcm2-hscdc6 direct interaction relationship: participates_in CCO:I0006130 ! mcm2-cdk4 direct interaction relationship: participates_in CCO:I0006142 ! mcm2-cdkn2a direct interaction relationship: participates_in CCO:I0006856 ! plk1-mcm2-1 physical interaction relationship: participates_in CCO:I0007914 ! mcm2-7_human physical interaction relationship: participates_in CCO:I0008109 ! gnb5-mcm2 physical interaction relationship: participates_in CCO:I0008152 ! prei3-mcm2 physical interaction relationship: participates_in CCO:I0008264 ! mcm2-rps4x physical interaction relationship: participates_in CCO:I0008275 ! mpp3-mcm2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012805 ! MCM2_HUMAN-Phosphoserine13 relationship: transforms_into CCO:B0012806 ! MCM2_HUMAN-Phosphoserine26 relationship: transforms_into CCO:B0012807 ! MCM2_HUMAN-Phosphoserine27 relationship: transforms_into CCO:B0012808 ! MCM2_HUMAN-Phosphothreonine39 relationship: transforms_into CCO:B0012809 ! MCM2_HUMAN-Phosphoserine40 relationship: transforms_into CCO:B0012810 ! MCM2_HUMAN-Phosphoserine41 relationship: transforms_into CCO:B0012811 ! MCM2_HUMAN-Phosphothreonine106 relationship: transforms_into CCO:B0012812 ! MCM2_HUMAN-Phosphoserine108 relationship: transforms_into CCO:B0012813 ! MCM2_HUMAN-Phosphoserine139 relationship: transforms_into CCO:B0032850 ! MCM2_HUMAN-Phosphoserine53 [Term] id: CCO:B0001636 name: FHIT_HUMAN def: "Bis(5'-adenosyl)-triphosphatase" [UniProtKB:P49789] synonym: "AP3A hydrolase" EXACT [UniProtKB:P49789] synonym: "AP3Aase" EXACT [UniProtKB:P49789] synonym: "Diadenosine 5',5'''-P1,P3-triphosphate hydrolase" EXACT [UniProtKB:P49789] synonym: "Dinucleosidetriphosphatase" EXACT [UniProtKB:P49789] synonym: "EC 3.6.1.29" EXACT [UniProtKB:P49789] synonym: "Fragile histidine triad protein" EXACT [UniProtKB:P49789] xref: EMBL:AAA99013.1 xref: EMBL:AAB52539.1 xref: EMBL:AAH32336.1 xref: EMBL:AAT37530.1 xref: UniProtKB:P49789 xref: UniProtKB:Q6IU12 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004645 ! FHIT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005738 ! fhit-fhit physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011881 ! FHIT_HUMAN-Phosphotyrosine114 relationship: transforms_into CCO:B0011882 ! FHIT_HUMAN-Phosphotyrosine145 [Term] id: CCO:B0001637 name: TSC2_HUMAN def: "Tuberin" [UniProtKB:P49815] synonym: "Tuberous sclerosis 2 protein" EXACT [UniProtKB:P49815] xref: EMBL:AAB41564.1 xref: EMBL:AAC34210.1 xref: EMBL:AAH25364.1 xref: EMBL:AAH46929.1 xref: EMBL:BAA32694.1 xref: EMBL:CAA53287.1 xref: UniProtKB:O75275 xref: UniProtKB:P49815 xref: UniProtKB:Q8TAZ1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005840 ! TSC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007275 ! nek1-tsc2-1 physical interaction relationship: participates_in CCO:I0007277 ! nek1-tsc2-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0014542 ! TSC2_HUMAN-Phosphoserine981 relationship: transforms_into CCO:B0014543 ! TSC2_HUMAN-Phosphoserine1364 relationship: transforms_into CCO:B0014544 ! TSC2_HUMAN-Phosphoserine1387 relationship: transforms_into CCO:B0014545 ! TSC2_HUMAN-Phosphoserine1411 relationship: transforms_into CCO:B0014546 ! TSC2_HUMAN-Phosphoserine1418 relationship: transforms_into CCO:B0014547 ! TSC2_HUMAN-Phosphoserine1420 relationship: transforms_into CCO:B0014548 ! TSC2_HUMAN-Phosphoserine1798 [Term] id: CCO:B0001638 name: DNL3_HUMAN def: "DNA ligase 3" [UniProtKB:P49916] synonym: "DNA ligase III" EXACT [UniProtKB:P49916] synonym: "EC 6.5.1.1" EXACT [UniProtKB:P49916] synonym: "Polydeoxyribonucleotide synthase [ATP] 3" EXACT [UniProtKB:P49916] xref: EMBL:AAA85022.1 xref: EMBL:AAL91592.1 xref: EMBL:CAA59230.1 xref: UniProtKB:P49916 xref: UniProtKB:Q16714 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004493 ! LIG3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000122 ! meiotic recombination relationship: transforms_into CCO:B0011563 ! DNL3_HUMAN-Phosphothreonine122 relationship: transforms_into CCO:B0011564 ! DNL3_HUMAN-Phosphoserine123 [Term] id: CCO:B0001639 name: DNL4_HUMAN def: "DNA ligase 4" [UniProtKB:P49917] synonym: "DNA ligase IV" EXACT [UniProtKB:P49917] synonym: "EC 6.5.1.1" EXACT [UniProtKB:P49917] synonym: "Polydeoxyribonucleotide synthase [ATP] 4" EXACT [UniProtKB:P49917] xref: EMBL:AAH37491.1 xref: EMBL:AAL77435.1 xref: EMBL:CAA58467.1 xref: EMBL:CAH70629.1 xref: UniProtKB:P49917 xref: UniProtKB:Q8IY66 xref: UniProtKB:Q8TEU5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004494 ! LIG4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006771 ! lig4-xrcc4-1 direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0035999 ! DNL4_HUMAN-Phosphothreonine347 [Term] id: CCO:B0001640 name: CDN1C_HUMAN def: "Cyclin-dependent kinase inhibitor 1C" [UniProtKB:P49918] synonym: "Cyclin-dependent kinase inhibitor p57" EXACT [UniProtKB:P49918] synonym: "p57KIP2" EXACT [UniProtKB:P49918] xref: EMBL:AAA85095.1 xref: EMBL:AAB05896.1 xref: EMBL:AAH67842.1 xref: EMBL:BAA11014.1 xref: EMBL:BAA11015.1 xref: UniProtKB:P49918 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004311 ! CDKN1C_human relationship: has_function CCO:F0001216 ! protein kinase inhibitor activity relationship: has_function CCO:F0001217 ! cyclin-dependent protein kinase inhibitor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0007546 ! cdk4-cdkn1c-1 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001641 name: MRE11_HUMAN def: "Double-strand break repair protein MRE11A" [UniProtKB:P49959] synonym: "MRE11 homolog 1" EXACT [UniProtKB:P49959] synonym: "MRE11 meiotic recombination 11 homolog A" EXACT [UniProtKB:P49959] xref: EMBL:AAC36249.1 xref: EMBL:AAC78721.1 xref: EMBL:AAD10197.1 xref: EMBL:AAH63458.1 xref: EMBL:AAK18790.1 xref: EMBL:AAS79320.1 xref: UniProtKB:O43475 xref: UniProtKB:P49959 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005124 ! MRE11A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006202 ! ccne1-mre11a-1 physical interaction relationship: participates_in CCO:I0006516 ! nbs1-mre11a-1 physical interaction relationship: participates_in CCO:I0006517 ! h2afx-mre11a-2 physical interaction relationship: participates_in CCO:I0006960 ! mdc1-atm-1 physical interaction relationship: participates_in CCO:I0007271 ! nek1-mre11-1 physical interaction relationship: participates_in CCO:I0007850 ! h2afx-mre11a-1 colocalization relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000122 ! meiotic recombination relationship: transforms_into CCO:B0013010 ! MRE11_HUMAN-Phosphothreonine74 relationship: transforms_into CCO:B0013011 ! MRE11_HUMAN-Phosphoserine678 relationship: transforms_into CCO:B0013012 ! MRE11_HUMAN-Phosphoserine688 relationship: transforms_into CCO:B0013013 ! MRE11_HUMAN-Phosphoserine689 [Term] id: CCO:B0001643 name: DYN2_HUMAN def: "Dynamin-2" [UniProtKB:P50570] synonym: "EC 3.6.5.5" EXACT [UniProtKB:P50570] xref: EMBL:AAA88025.1 xref: EMBL:AAD23604.1 xref: EMBL:AAH39596.1 xref: EMBL:AAH54501.1 xref: UniProtKB:P50570 xref: UniProtKB:Q5I0Y0 xref: UniProtKB:Q7Z5S3 xref: UniProtKB:Q9UPH4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004528 ! DNM2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006072 ! fnbp1-dnm2-2 physical interaction relationship: participates_in CCO:I0006491 ! mphosph6-dnm2 physical interaction relationship: participates_in CCO:I0006507 ! q9nx70-q71f56-1 physical interaction relationship: participates_in CCO:I0007329 ! hck-dnm2-1 physical interaction relationship: participates_in CCO:I0007506 ! fnbp1-dnm2-1 colocalization relationship: participates_in CCO:I0008383 ! dnm2-bat1 physical interaction relationship: participates_in CCO:I0008470 ! dnm2-eif3s6ip physical interaction relationship: participates_in CCO:I0008471 ! dnm2-pef1 physical interaction relationship: participates_in CCO:I0008472 ! dnm2-ppib physical interaction relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: transforms_into CCO:B0011602 ! DYN2_HUMAN-Phosphoserine298 relationship: transforms_into CCO:B0011603 ! DYN2_HUMAN-Phosphoserine302 relationship: transforms_into CCO:B0011604 ! DYN2_HUMAN-Phosphotyrosine597 relationship: transforms_into CCO:B0011605 ! DYN2_HUMAN-Phosphothreonine766 [Term] id: CCO:B0001644 name: CDK7_HUMAN def: "Cell division protein kinase 7" [UniProtKB:P50613] synonym: "39 kDa protein kinase" EXACT [UniProtKB:P50613] synonym: "CAK" EXACT [UniProtKB:P50613] synonym: "CAK1" EXACT [UniProtKB:P50613] synonym: "CDK-activating kinase" EXACT [UniProtKB:P50613] synonym: "EC 2.7.11.22" EXACT [UniProtKB:P50613] synonym: "EC 2.7.11.23" EXACT [UniProtKB:P50613] synonym: "P39 Mo15" EXACT [UniProtKB:P50613] synonym: "STK1" EXACT [UniProtKB:P50613] synonym: "TFIIH basal transcription factor complex kinase subunit" EXACT [UniProtKB:P50613] xref: EMBL:AAA36657.1 xref: EMBL:AAH00834.1 xref: EMBL:AAH05298.1 xref: EMBL:AAM77799.1 xref: EMBL:CAA54508.1 xref: EMBL:CAA54793.1 xref: EMBL:CAA55785.1 xref: EMBL:CAA73587.1 xref: UniProtKB:P50613 xref: UniProtKB:Q9BS60 xref: UniProtKB:Q9UE19 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004304 ! CDK7_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000300 ! transcription coactivator activity relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001060 ! cyclin-dependent protein kinase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0001846 ! RNA polymerase subunit kinase activity relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0007990 ! androgen receptor binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011118 ! CDK7_HUMAN-Phosphoserine164 relationship: transforms_into CCO:B0011119 ! CDK7_HUMAN-Phosphothreonine170 [Term] id: CCO:B0001645 name: KNTC1_HUMAN def: "Kinetochore-associated protein 1" [UniProtKB:P50748] synonym: "hRod" EXACT [UniProtKB:P50748] synonym: "HsROD" EXACT [UniProtKB:P50748] synonym: "Rod" EXACT [UniProtKB:P50748] synonym: "Rough deal homolog" EXACT [UniProtKB:P50748] xref: EMBL:BAA11483.2 xref: UniProtKB:P50748 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004955 ! KNTC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007819 ! zw10_zwilch_1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis relationship: transforms_into CCO:B0012613 ! KNTC1_HUMAN-Phosphoserine2098 [Term] id: CCO:B0001646 name: RASF2_HUMAN def: "Ras association domain-containing protein 2" [UniProtKB:P50749] xref: EMBL:AAI17119.1 xref: EMBL:AAI17121.1 xref: EMBL:AAN59975.1 xref: EMBL:AAN59977.1 xref: EMBL:BAA11485.2 xref: EMBL:BAD96370.1 xref: EMBL:CAC34362.1 xref: EMBL:CAH10522.1 xref: UniProtKB:P50749 xref: UniProtKB:Q17S06 xref: UniProtKB:Q53HD0 xref: UniProtKB:Q6AHZ2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005430 ! RASSF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007375 ! kras-rassf2-1 physical interaction relationship: participates_in CCO:I0007412 ! krs-rassf2-2 direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001649 name: BRCA2_HUMAN def: "Breast cancer type 2 susceptibility protein" [UniProtKB:P51587] synonym: "Fanconi anemia group D1 protein" EXACT [UniProtKB:P51587] xref: EMBL:AAB07223.1 xref: EMBL:AAQ97181.1 xref: EMBL:CAA64484.1 xref: EMBL:CAA97728.1 xref: EMBL:CAA98995.2 xref: UniProtKB:O00183 xref: UniProtKB:O15008 xref: UniProtKB:P51587 xref: UniProtKB:Q13879 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004187 ! BRCA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006002 ! rad51-brca2-1 physical interaction relationship: participates_in CCO:I0006281 ! fancd2-brca2-2 physical interaction relationship: participates_in CCO:I0006543 ! brca2-shfdg1-2 physical interaction relationship: participates_in CCO:I0006670 ! brca2-shfdg1-3 physical interaction relationship: participates_in CCO:I0006671 ! shfdg1-brca2-3 physical interaction relationship: participates_in CCO:I0006841 ! brca2-rad51-2 physical interaction relationship: participates_in CCO:I0006948 ! brca2-rad51-1 physical interaction relationship: participates_in CCO:I0007010 ! brca2-rad51-9 physical interaction relationship: participates_in CCO:I0007073 ! fancd2-brca2-1 physical interaction relationship: participates_in CCO:I0007133 ! brca2-shfdg1-1 physical interaction relationship: participates_in CCO:I0007151 ! brca2-rad51-8 physical interaction relationship: participates_in CCO:I0007723 ! brca2-rad51-4 physical interaction relationship: participates_in CCO:I0007925 ! brca2-rad51-5 physical interaction relationship: participates_in CCO:I0007926 ! brca2-rad51-6 direct interaction relationship: participates_in CCO:I0007927 ! brca2-rad51-7 physical interaction relationship: participates_in CCO:I0007947 ! brca2-rad51-3 physical interaction relationship: participates_in CCO:P0000101 ! regulation of S phase of mitotic cell cycle relationship: participates_in CCO:P0000212 ! cytokinesis during cell cycle relationship: participates_in CCO:P0000300 ! centrosome duplication relationship: transforms_into CCO:B0010859 ! BRCA2_HUMAN-Phosphoserine683 relationship: transforms_into CCO:B0010860 ! BRCA2_HUMAN-Phosphoserine755 [Term] id: CCO:B0001650 name: HCFC1_HUMAN def: "Host cell factor" [UniProtKB:P51610] synonym: "C1 factor" EXACT [UniProtKB:P51610] synonym: "CFF" EXACT [UniProtKB:P51610] synonym: "HCF" EXACT [UniProtKB:P51610] synonym: "HCF-1" EXACT [UniProtKB:P51610] synonym: "VCAF" EXACT [UniProtKB:P51610] synonym: "VP16 accessory protein" EXACT [UniProtKB:P51610] xref: EMBL:AAH63435.1 xref: EMBL:CAA55790.1 xref: UniProtKB:P51610 xref: UniProtKB:Q6P4G5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004782 ! HCFC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006030 ! hcfc1-many-4 physical interaction relationship: participates_in CCO:I0006302 ! hcfc1-hdac1-1 physical interaction relationship: participates_in CCO:I0006303 ! hcfc1-hdac2-1 physical interaction relationship: participates_in CCO:I0006304 ! hcfc1-sp1-1 physical interaction relationship: participates_in CCO:I0006305 ! mll-hcfc2-2 physical interaction relationship: participates_in CCO:I0006313 ! hcfc1-zbtb17-9 physical interaction relationship: participates_in CCO:I0006323 ! hcfc1-creb3-2 physical interaction relationship: participates_in CCO:I0006523 ! hcfc1-zbtb17-3 physical interaction relationship: participates_in CCO:I0006624 ! hcfc1-set1-1 physical interaction relationship: participates_in CCO:I0006625 ! hcfc1-ash2l-1 physical interaction relationship: participates_in CCO:I0006626 ! hcfc1-wdr5-1 physical interaction relationship: participates_in CCO:I0006868 ! hcfc1-gabp2b1-2 physical interaction relationship: participates_in CCO:I0006869 ! hcfc1-zbtb17-2 physical interaction relationship: participates_in CCO:I0006972 ! hcfc1-many-3 physical interaction relationship: participates_in CCO:I0006973 ! hcfc1-zf-1 physical interaction relationship: participates_in CCO:I0006974 ! hcfc1-zf-3 physical interaction relationship: participates_in CCO:I0007094 ! hcfc1-ogt-1 physical interaction relationship: participates_in CCO:I0007095 ! hcfc1-sin3a-1 physical interaction relationship: participates_in CCO:I0007096 ! hcfc1-sin3b-1 physical interaction relationship: participates_in CCO:I0007097 ! hcfc1-sds3-1 physical interaction relationship: participates_in CCO:I0007098 ! hcfc1-hcfc1-1 physical interaction relationship: participates_in CCO:I0007115 ! hcfc1-zbtb17-4 physical interaction relationship: participates_in CCO:I0007116 ! hcfc1-zbtb17-5 physical interaction relationship: participates_in CCO:I0007117 ! hcfc1-zbtb17-6 physical interaction relationship: participates_in CCO:I0007118 ! hcfc1-zbtb17-7 physical interaction relationship: participates_in CCO:I0007119 ! hcfc1-zbtb17-8 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: participates_in CCO:I0007251 ! hcfc1-sin3a-2 physical interaction relationship: participates_in CCO:I0007261 ! hcfc1-gabp2-3 physical interaction relationship: participates_in CCO:I0007262 ! hcfc1-gabpa-1 physical interaction relationship: participates_in CCO:I0007263 ! hcfc1-gabp2-4 direct interaction relationship: participates_in CCO:I0007264 ! hcfc1-creb3-3 direct interaction relationship: participates_in CCO:I0007265 ! hcfc1-zf-6 direct interaction relationship: participates_in CCO:I0007266 ! hcfc1-creb3-4 direct interaction relationship: participates_in CCO:I0007267 ! hcfc1-zf-7 direct interaction relationship: participates_in CCO:I0007355 ! hcfc1-many-2 physical interaction relationship: participates_in CCO:I0007561 ! hcfc1-sin3a-3 physical interaction relationship: participates_in CCO:I0007562 ! hcfc1-ash2l-2 physical interaction relationship: participates_in CCO:I0007565 ! hcfc1-zbtb17-1 physical interaction relationship: participates_in CCO:I0007752 ! hcfc1-creb3-1 physical interaction relationship: participates_in CCO:I0007754 ! hcfc1-zf-4 physical interaction relationship: participates_in CCO:I0007755 ! hcfc1-zf-5 physical interaction relationship: participates_in CCO:I0007872 ! hcfc1-pou2f1-1 physical interaction relationship: participates_in CCO:I0007873 ! hcfc1-egr2-1 physical interaction relationship: participates_in CCO:I0007875 ! hcfc1-zf-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000247 ! positive regulation of cell cycle relationship: transforms_into CCO:B0012144 ! HCFC1_HUMAN-Phosphoserine598 relationship: transforms_into CCO:B0012145 ! HCFC1_HUMAN-Phosphoserine666 relationship: transforms_into CCO:B0012146 ! HCFC1_HUMAN-Phosphothreonine733 relationship: transforms_into CCO:B0012147 ! HCFC1_HUMAN-Phosphothreonine737 relationship: transforms_into CCO:B0012148 ! HCFC1_HUMAN-Phosphothreonine738 relationship: transforms_into CCO:B0012149 ! HCFC1_HUMAN-Phosphothreonine1491 relationship: transforms_into CCO:B0012150 ! HCFC1_HUMAN-Phosphoserine1507 relationship: transforms_into CCO:B0012151 ! HCFC1_HUMAN-Phosphoserine2007 relationship: transforms_into CCO:B0012152 ! HCFC1_HUMAN-Phosphoserine2008 relationship: transforms_into CCO:B0012153 ! HCFC1_HUMAN-Phosphoserine2020 [Term] id: CCO:B0001652 name: CCNH_HUMAN def: "Cyclin-H" [UniProtKB:P51946] synonym: "MO15-associated protein" EXACT [UniProtKB:P51946] synonym: "p34" EXACT [UniProtKB:P51946] synonym: "p37" EXACT [UniProtKB:P51946] xref: EMBL:AAA21361.1 xref: EMBL:AAA57006.1 xref: EMBL:AAH05280.1 xref: EMBL:AAH16705.1 xref: EMBL:AAH16823.1 xref: EMBL:AAH22351.1 xref: EMBL:AAL74271.1 xref: UniProtKB:P51946 xref: UniProtKB:Q8TBL9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004256 ! CCNH_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005734 ! ccnh-sssca1 physical interaction relationship: participates_in CCO:I0005799 ! ccnh-psma1 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0010998 ! CCNH_HUMAN-Phosphoserine5 relationship: transforms_into CCO:B0010999 ! CCNH_HUMAN-Phosphoserine304 relationship: transforms_into CCO:B0011000 ! CCNH_HUMAN-Phosphothreonine315 [Term] id: CCO:B0001653 name: MAT1_HUMAN def: "CDK-activating kinase assembly factor MAT1" [UniProtKB:P51948] synonym: "CDK7/cyclin H assembly factor" EXACT [UniProtKB:P51948] synonym: "Cyclin G1-interacting protein" EXACT [UniProtKB:P51948] synonym: "Menage a trois" EXACT [UniProtKB:P51948] synonym: "p35" EXACT [UniProtKB:P51948] synonym: "p36" EXACT [UniProtKB:P51948] synonym: "RING finger protein 66" EXACT [UniProtKB:P51948] synonym: "RING finger protein MAT1" EXACT [UniProtKB:P51948] xref: EMBL:AAB05248.1 xref: EMBL:AAH00820.1 xref: EMBL:AAN47195.1 xref: EMBL:CAA61112.1 xref: EMBL:CAA63356.1 xref: UniProtKB:P51948 xref: UniProtKB:Q15817 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005030 ! MNAT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008268 ! mnat1-cops6 physical interaction relationship: participates_in CCO:I0008269 ! mnat1-dkfzp564o0523 physical interaction relationship: participates_in CCO:I0008270 ! mnat1-eef1a1 physical interaction relationship: participates_in CCO:I0008271 ! mnat1-rif1 physical interaction relationship: participates_in CCO:I0008408 ! mnat1-hps6 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001654 name: NEK2_HUMAN def: "Serine/threonine-protein kinase Nek2" [UniProtKB:P51955] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P51955] synonym: "HSPK 21" EXACT [UniProtKB:P51955] synonym: "NimA-like protein kinase 1" EXACT [UniProtKB:P51955] synonym: "NimA-related protein kinase 2" EXACT [UniProtKB:P51955] xref: EMBL:AAA19558.1 xref: EMBL:AAH43502.2 xref: EMBL:AAH52807.1 xref: EMBL:AAH65932.1 xref: EMBL:AAK92212.1 xref: EMBL:AAV38534.1 xref: EMBL:BAD97073.1 xref: EMBL:CAA80912.1 xref: EMBL:CAA82309.1 xref: EMBL:CAH72901.1 xref: UniProtKB:P51955 xref: UniProtKB:Q53FD6 xref: UniProtKB:Q5VXZ1 xref: UniProtKB:Q6NZX8 xref: UniProtKB:Q7Z634 xref: UniProtKB:Q86XH2 xref: UniProtKB:Q96QN9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005176 ! NEK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006730 ! nek2-nek11-6 physical interaction relationship: participates_in CCO:I0006870 ! nek2-nek11-2 colocalization relationship: participates_in CCO:I0006871 ! nek2-nek11-5 physical interaction relationship: participates_in CCO:I0006975 ! nek2-nek11-1 colocalization relationship: participates_in CCO:I0006976 ! nek2-nek11-7 phosphorylation relationship: participates_in CCO:I0007814 ! cdc27-nek2-1 physical interaction relationship: participates_in CCO:I0007929 ! cdc27-nek2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000099 ! regulation of mitosis relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0013148 ! NEK2_HUMAN-Phosphothreonine175 relationship: transforms_into CCO:B0031348 ! NEK2_HUMAN-Phosphothreonine170 relationship: transforms_into CCO:B0031349 ! NEK2_HUMAN-Phosphoserine171 relationship: transforms_into CCO:B0031350 ! NEK2_HUMAN-Phosphothreonine179 relationship: transforms_into CCO:B0031351 ! NEK2_HUMAN-Phosphoserine241 relationship: transforms_into CCO:B0031352 ! NEK2_HUMAN-Phosphoserine356 relationship: transforms_into CCO:B0031353 ! NEK2_HUMAN-Phosphoserine387 relationship: transforms_into CCO:B0031354 ! NEK2_HUMAN-Phosphoserine390 relationship: transforms_into CCO:B0031355 ! NEK2_HUMAN-Phosphoserine397 relationship: transforms_into CCO:B0031356 ! NEK2_HUMAN-Phosphoserine402 relationship: transforms_into CCO:B0031357 ! NEK2_HUMAN-Phosphoserine428 [Term] id: CCO:B0001655 name: NEK4_HUMAN def: "Serine/threonine-protein kinase Nek4" [UniProtKB:P51957] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P51957] synonym: "NimA-related protein kinase 4" EXACT [UniProtKB:P51957] synonym: "Serine/threonine-protein kinase 2" EXACT [UniProtKB:P51957] synonym: "Serine/threonine-protein kinase NRK2" EXACT [UniProtKB:P51957] xref: EMBL:AAA36658.1 xref: UniProtKB:P51957 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005177 ! NEK4_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013149 ! NEK4_HUMAN-Phosphothreonine165 relationship: transforms_into CCO:B0013150 ! NEK4_HUMAN-Phosphoserine563 [Term] id: CCO:B0001656 name: CCNG1_HUMAN def: "Cyclin-G1" [UniProtKB:P51959] synonym: "Cyclin-G" EXACT [UniProtKB:P51959] xref: EMBL:AAB03903.1 xref: EMBL:AAC41977.1 xref: EMBL:AAC50688.1 xref: EMBL:AAH00196.1 xref: EMBL:AAH07093.1 xref: EMBL:AAP35798.1 xref: EMBL:AAV40836.1 xref: EMBL:BAA11353.1 xref: EMBL:BAA13007.1 xref: EMBL:CAA54821.1 xref: UniProtKB:P51959 xref: UniProtKB:Q15757 xref: UniProtKB:Q96L32 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004254 ! CCNG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001657 name: IMA2_HUMAN def: "Importin subunit alpha-2" [UniProtKB:P52292] synonym: "Karyopherin subunit alpha-2" EXACT [UniProtKB:P52292] synonym: "RAG cohort protein 1" EXACT [UniProtKB:P52292] synonym: "SRP1-alpha" EXACT [UniProtKB:P52292] xref: EMBL:AAA65700.1 xref: EMBL:AAA69957.1 xref: EMBL:AAH05978.1 xref: EMBL:CAC83080.1 xref: UniProtKB:P52292 xref: UniProtKB:Q9BRU5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004886 ! KPNA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006186 ! ok/sw_cl_16-kpna2 physical interaction relationship: participates_in CCO:I0006187 ! mageh1-kpna2 physical interaction relationship: participates_in CCO:I0006188 ! kiaa1377-kpna2 physical interaction relationship: participates_in CCO:I0006425 ! nfkbib-kpna2 physical interaction relationship: participates_in CCO:I0006438 ! relb-kpna2 physical interaction relationship: participates_in CCO:I0006506 ! q9nwa0-q71f56-1 physical interaction relationship: participates_in CCO:I0007525 ! kpna2-brca1 physical interaction relationship: participates_in CCO:I0007840 ! kpna-bcra1 physical interaction relationship: participates_in CCO:I0007841 ! bcra1-kpna2 physical interaction relationship: participates_in CCO:P0000003 ! M phase specific microtubule process relationship: participates_in CCO:P0000015 ! G2 phase of mitotic cell cycle relationship: transforms_into CCO:B0012375 ! IMA2_HUMAN-Phosphoserine24 relationship: transforms_into CCO:B0012376 ! IMA2_HUMAN-Phosphoserine62 relationship: transforms_into CCO:B0012377 ! IMA2_HUMAN-Phosphoserine490 [Term] id: CCO:B0001658 name: MP2K6_HUMAN def: "Dual specificity mitogen-activated protein kinase kinase 6" [UniProtKB:P52564] synonym: "EC 2.7.12.2" EXACT [UniProtKB:P52564] synonym: "MAP kinase kinase 6" EXACT [UniProtKB:P52564] synonym: "MAPK/ERK kinase 6" EXACT [UniProtKB:P52564] synonym: "MAPKK 6" EXACT [UniProtKB:P52564] synonym: "SAPKK3" EXACT [UniProtKB:P52564] xref: EMBL:AAB03705.1 xref: EMBL:AAB03708.1 xref: EMBL:AAB05035.1 xref: EMBL:AAC50388.1 xref: EMBL:AAC50389.1 xref: EMBL:AAH12009.1 xref: EMBL:BAA13496.1 xref: EMBL:CAA65532.1 xref: UniProtKB:P52564 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005114 ! MAP2K6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007408 ! map3k4-map2k61 physical interaction relationship: participates_in CCO:I0007530 ! map3k4-gadd45 physical interaction relationship: participates_in CCO:I0007531 ! map3k4-gadd45-2 physical interaction relationship: participates_in CCO:I0007532 ! map3k4-gadd45-3 physical interaction relationship: participates_in CCO:I0007867 ! pkn1-map2k6-2 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0012976 ! MP2K6_HUMAN-O-acetylserine207 relationship: transforms_into CCO:B0012977 ! MP2K6_HUMAN-Phosphoserine207 relationship: transforms_into CCO:B0012978 ! MP2K6_HUMAN-O-acetylthreonine211 relationship: transforms_into CCO:B0012979 ! MP2K6_HUMAN-Phosphothreonine211 [Term] id: CCO:B0001659 name: KIF11_HUMAN def: "Kinesin-like protein KIF11" [UniProtKB:P52732] synonym: "Kinesin-like protein 1" EXACT [UniProtKB:P52732] synonym: "Kinesin-like spindle protein HKSP" EXACT [UniProtKB:P52732] synonym: "Kinesin-related motor protein Eg5" EXACT [UniProtKB:P52732] synonym: "Thyroid receptor-interacting protein 5" EXACT [UniProtKB:P52732] synonym: "TRIP-5" EXACT [UniProtKB:P52732] xref: EMBL:AAA86132.1 xref: EMBL:AAC41739.1 xref: EMBL:AAI26212.1 xref: EMBL:CAA59449.1 xref: EMBL:CAH72288.1 xref: EMBL:CAI13671.1 xref: UniProtKB:A0AV49 xref: UniProtKB:P52732 xref: UniProtKB:Q15716 xref: UniProtKB:Q5VWX0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004941 ! KIF11_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000321 ! motor activity relationship: has_function CCO:F0000322 ! microtubule motor activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000144 ! spindle pole relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000431 ! kinesin complex relationship: located_in CCO:C0000434 ! microtubule relationship: located_in CCO:C0000435 ! microtubule associated complex relationship: located_in CCO:C0000436 ! spindle microtubule relationship: participates_in CCO:I0006358 ! ikbke-kif11 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000068 ! mitotic spindle organization and biogenesis relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000302 ! spindle pole body organization and biogenesis relationship: transforms_into CCO:B0012583 ! KIF11_HUMAN-Phosphothreonine458 relationship: transforms_into CCO:B0012584 ! KIF11_HUMAN-Phosphothreonine926 relationship: transforms_into CCO:B0012585 ! KIF11_HUMAN-Phosphoserine931 [Term] id: CCO:B0001660 name: RBM5_HUMAN def: "RNA-binding protein 5" [UniProtKB:P52756] synonym: "Protein G15" EXACT [UniProtKB:P52756] synonym: "Renal carcinoma antigen NY-REN-9" EXACT [UniProtKB:P52756] synonym: "RNA-binding motif protein 5" EXACT [UniProtKB:P52756] synonym: "Tumor suppressor LUCA15" EXACT [UniProtKB:P52756] xref: EMBL:AAA99715.1 xref: EMBL:AAB42216.1 xref: EMBL:AAD04159.1 xref: EMBL:AAF02422.2 xref: UniProtKB:P52756 xref: UniProtKB:Q93021 xref: UniProtKB:Q9BU14 xref: UniProtKB:Q9UKY8 xref: UniProtKB:Q9UL24 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005448 ! RBM5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008156 ! rbm5-rif1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013789 ! RBM5_HUMAN-Phosphoserine59 relationship: transforms_into CCO:B0013790 ! RBM5_HUMAN-Phosphoserine69 relationship: transforms_into CCO:B0013791 ! RBM5_HUMAN-Phosphoserine621 relationship: transforms_into CCO:B0013792 ! RBM5_HUMAN-Phosphoserine624 [Term] id: CCO:B0001662 name: PPP5_HUMAN def: "Serine/threonine-protein phosphatase 5" [UniProtKB:P53041] synonym: "EC 3.1.3.16" EXACT [UniProtKB:P53041] synonym: "PP-T" EXACT [UniProtKB:P53041] synonym: "PP5" EXACT [UniProtKB:P53041] synonym: "PPT" EXACT [UniProtKB:P53041] synonym: "Protein phosphatase T" EXACT [UniProtKB:P53041] xref: EMBL:AAB60384.1 xref: EMBL:AAD22669.1 xref: EMBL:AAH01970.1 xref: EMBL:CAA61595.1 xref: EMBL:CAA63089.1 xref: UniProtKB:P53041 xref: UniProtKB:Q16722 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005369 ! PPP5C_human relationship: has_function CCO:F0001086 ! phosphoprotein phosphatase activity relationship: has_function CCO:F0001087 ! protein serine/threonine phosphatase activity relationship: has_function CCO:F0001225 ! signal transducer activity relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0001643 ! iron ion binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0006803 ! disc1-ppp5c physical interaction relationship: participates_in CCO:I0008297 ! ppp5c-cse1l physical interaction relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001663 name: PLK1_HUMAN def: "Serine/threonine-protein kinase PLK1" [UniProtKB:P53350] synonym: "EC 2.7.11.21" EXACT [UniProtKB:P53350] synonym: "PLK-1" EXACT [UniProtKB:P53350] synonym: "Polo-like kinase 1" EXACT [UniProtKB:P53350] synonym: "Serine/threonine-protein kinase 13" EXACT [UniProtKB:P53350] synonym: "STPK13" EXACT [UniProtKB:P53350] xref: EMBL:AAA36659.1 xref: EMBL:AAA56634.1 xref: EMBL:AAB36946.1 xref: EMBL:AAH02369.1 xref: EMBL:AAH03002.1 xref: EMBL:AAH14846.1 xref: EMBL:CAA51837.1 xref: EMBL:CAA53536.1 xref: EMBL:CAA62260.1 xref: UniProtKB:P53350 xref: UniProtKB:Q15153 xref: UniProtKB:Q99746 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005337 ! PLK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006705 ! plk1-mcm7-3 physical interaction relationship: participates_in CCO:I0006855 ! plk1-mcm7-1 physical interaction relationship: participates_in CCO:I0006856 ! plk1-mcm2-1 physical interaction relationship: participates_in CCO:I0006955 ! plk1-mcm7-2 physical interaction relationship: participates_in CCO:I0006956 ! plk1-mcm3-1 physical interaction relationship: participates_in CCO:I0006957 ! plk1-mcm7-4 physical interaction relationship: participates_in CCO:I0006995 ! fbxo5-plk1 phosphorylation relationship: participates_in CCO:I0006996 ! fbxo5-plk1-1 phosphorylation relationship: participates_in CCO:I0007915 ! wee1-plk1 phosphorylation relationship: participates_in CCO:I0008100 ! dnajb9-plk1 physical interaction relationship: participates_in CCO:I0008207 ! c7orf20-plk1 physical interaction relationship: participates_in CCO:I0008263 ! maged1-plk1 physical interaction relationship: participates_in CCO:I0008308 ! recql5-plk1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0013568 ! PLK1_HUMAN-Phosphoserine137 relationship: transforms_into CCO:B0013569 ! PLK1_HUMAN-Phosphothreonine210 relationship: transforms_into CCO:B0013570 ! PLK1_HUMAN-Phosphoserine269 relationship: transforms_into CCO:B0013571 ! PLK1_HUMAN-Phosphoserine335 [Term] id: CCO:B0001665 name: MK12_HUMAN def: "Mitogen-activated protein kinase 12" [UniProtKB:P53778] synonym: "EC 2.7.11.24" EXACT [UniProtKB:P53778] synonym: "ERK-6" EXACT [UniProtKB:P53778] synonym: "ERK5" EXACT [UniProtKB:P53778] synonym: "Extracellular signal-regulated kinase 6" EXACT [UniProtKB:P53778] synonym: "MAP kinase p38 gamma" EXACT [UniProtKB:P53778] synonym: "Mitogen-activated protein kinase p38 gamma" EXACT [UniProtKB:P53778] synonym: "Stress-activated protein kinase 3" EXACT [UniProtKB:P53778] xref: EMBL:AAB40118.1 xref: EMBL:AAH15741.1 xref: EMBL:CAA55984.1 xref: EMBL:CAA71511.1 xref: EMBL:CAB51538.1 xref: UniProtKB:P53778 xref: UniProtKB:Q14260 xref: UniProtKB:Q99588 xref: UniProtKB:Q99672 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005095 ! MAPK12_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007865 ! pkn1-mapk12-1 physical interaction relationship: participates_in CCO:I0007866 ! pkn1-mapk12-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0012956 ! MK12_HUMAN-Phosphotyrosine27 relationship: transforms_into CCO:B0012957 ! MK12_HUMAN-Phosphothreonine183 relationship: transforms_into CCO:B0012958 ! MK12_HUMAN-Phosphotyrosine185 [Term] id: CCO:B0001666 name: HRSL3_HUMAN def: "HRAS-like suppressor 3" [UniProtKB:P53816] synonym: "H-rev 107 protein homolog" EXACT [UniProtKB:P53816] synonym: "HREV107-3" EXACT [UniProtKB:P53816] synonym: "Renal carcinoma antigen NY-REN-65" EXACT [UniProtKB:P53816] xref: EMBL:AAH01387.1 xref: EMBL:AAI03808.1 xref: EMBL:AAL26892.1 xref: EMBL:BAB08108.1 xref: EMBL:CAA63423.1 xref: UniProtKB:P53816 xref: UniProtKB:Q3SYI3 xref: UniProtKB:Q9HDD1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004828 ! HRASLS3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005789 ! hrasls3-ubqln1 physical interaction relationship: participates_in CCO:I0006640 ! hrasls3-ubqln4 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001667 name: TERF1_HUMAN def: "Telomeric repeat-binding factor 1" [UniProtKB:P54274] synonym: "NIMA-interacting protein 2" EXACT [UniProtKB:P54274] synonym: "Telomeric protein Pin2/TRF1" EXACT [UniProtKB:P54274] synonym: "TTAGGG repeat-binding factor 1" EXACT [UniProtKB:P54274] xref: EMBL:AAB17975.1 xref: EMBL:AAB53363.1 xref: EMBL:AAB54036.1 xref: EMBL:AAB81137.1 xref: EMBL:CAA63768.1 xref: UniProtKB:P54274 xref: UniProtKB:Q15553 xref: UniProtKB:Q93029 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005760 ! TERF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005963 ! pin2_trf1-eb1-1 physical interaction relationship: participates_in CCO:I0006326 ! blm-terf1-6 direct interaction relationship: participates_in CCO:I0006879 ! blm-terf1-7 direct interaction relationship: participates_in CCO:I0006880 ! blm-terf1-8 direct interaction relationship: participates_in CCO:I0007458 ! eb1-pin2_trf1-1 physical interaction relationship: participates_in CCO:I0007697 ! atm-pin2_trf1-1 physical interaction relationship: participates_in CCO:I0007698 ! pin2_trf1-atm-2 physical interaction relationship: participates_in CCO:I0007893 ! pot1-terf2-1 physical interaction relationship: participates_in CCO:I0007894 ! tinf2-terf1-1 physical interaction relationship: participates_in CCO:I0008172 ! terf1-git1 physical interaction relationship: participates_in CCO:I0008173 ! terf1-pfn2 physical interaction relationship: participates_in CCO:I0008174 ! terf1-zhx1 physical interaction relationship: participates_in CCO:I0008337 ! terf1-utp14a physical interaction relationship: participates_in CCO:I0008338 ! terf1-tinf2 physical interaction relationship: participates_in CCO:I0008437 ! terf1-capns1 physical interaction relationship: participates_in CCO:I0008438 ! terf1-dlg5 physical interaction relationship: participates_in CCO:I0008439 ! terf1-sh3gl3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014332 ! TERF1_HUMAN-Phosphoserine11 relationship: transforms_into CCO:B0014333 ! TERF1_HUMAN-Phosphoserine219 [Term] id: CCO:B0001668 name: PMS1_HUMAN def: "PMS1 protein homolog 1" [UniProtKB:P54277] synonym: "DNA mismatch repair protein PMS1" EXACT [UniProtKB:P54277] xref: EMBL:AAA63922.1 xref: EMBL:AAO89079.1 xref: UniProtKB:P54277 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005345 ! PMS1_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0004616 ! mismatched DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001669 name: PMS2_HUMAN def: "Mismatch repair endonuclease PMS2" [UniProtKB:P54278] synonym: "DNA mismatch repair protein PMS2" EXACT [UniProtKB:P54278] synonym: "EC 3.1.-.-" EXACT [UniProtKB:P54278] synonym: "PMS1 protein homolog 2" EXACT [UniProtKB:P54278] xref: EMBL:AAA50390.1 xref: EMBL:AAA63923.1 xref: EMBL:AAH93921.1 xref: EMBL:AAS00390.1 xref: EMBL:BAD89425.1 xref: EMBL:BAD89426.1 xref: EMBL:BAD89428.1 xref: UniProtKB:P54278 xref: UniProtKB:Q52LH6 xref: UniProtKB:Q5FBW9 xref: UniProtKB:Q5FBX1 xref: UniProtKB:Q5FBX2 xref: UniProtKB:Q75MR2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005346 ! PMS2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007475 ! pms2-mlh1 direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013585 ! PMS2_HUMAN-Phosphotyrosine181 relationship: transforms_into CCO:B0013586 ! PMS2_HUMAN-Phosphoserine403 relationship: transforms_into CCO:B0013587 ! PMS2_HUMAN-Phosphothreonine573 [Term] id: CCO:B0001670 name: HSP72_HUMAN def: "Heat shock-related 70 kDa protein 2" [UniProtKB:P54652] synonym: "Heat shock 70 kDa protein 2" EXACT [UniProtKB:P54652] xref: EMBL:AAA52698.1 xref: EMBL:AAC50076.1 xref: EMBL:AAD11466.1 xref: EMBL:AAH01752.1 xref: EMBL:AAH36107.1 xref: EMBL:AAP88817.1 xref: EMBL:ABE96830.1 xref: UniProtKB:P54652 xref: UniProtKB:Q15508 xref: UniProtKB:Q53XM3 xref: UniProtKB:Q9UE78 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004836 ! HSPA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005756 ! hspa2-hspbp1 physical interaction relationship: participates_in CCO:I0006373 ! map3k3-hspa2 physical interaction relationship: participates_in CCO:I0006394 ! ripk2-hspa2 physical interaction relationship: participates_in CCO:I0006407 ! q9nyj8-hspa2 physical interaction relationship: participates_in CCO:I0006652 ! ewsr1-hspa2 physical interaction relationship: participates_in CCO:I0006653 ! hspbp1-hspa2 physical interaction relationship: participates_in CCO:I0006654 ! meox2-hspa2 physical interaction relationship: participates_in CCO:I0006663 ! hspa2-hspbp1-1 physical interaction relationship: participates_in CCO:I0007478 ! cftr-ebp physical interaction relationship: participates_in CCO:I0007836 ! cftr-ebp-2 physical interaction relationship: participates_in CCO:P0000131 ! male meiosis [Term] id: CCO:B0001671 name: BCAT1_HUMAN def: "Branched-chain-amino-acid aminotransferase, cytosolic" [UniProtKB:P54687] synonym: "BCAT(c)" EXACT [UniProtKB:P54687] synonym: "EC 2.6.1.42" EXACT [UniProtKB:P54687] synonym: "Protein ECA39" EXACT [UniProtKB:P54687] xref: EMBL:AAB08528.1 xref: EMBL:BAB71129.1 xref: UniProtKB:P54687 xref: UniProtKB:Q96MY9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004148 ! BCAT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle [Term] id: CCO:B0001672 name: GAS1_HUMAN def: "Growth arrest-specific protein 1 precursor" [UniProtKB:P54826] synonym: "GAS-1" EXACT [UniProtKB:P54826] xref: EMBL:AAA72368.1 xref: UniProtKB:P54826 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004682 ! GAS1_human relationship: has_function CCO:F0000272 ! molecular_function relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0001149 ! anchored to membrane relationship: located_in CCO:C0001959 ! anchored to plasma membrane relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000244 ! negative regulation of S phase of mitotic cell cycle [Term] id: CCO:B0001673 name: AIF1_HUMAN def: "Allograft inflammatory factor 1" [UniProtKB:P55008] synonym: "AIF-1" EXACT [UniProtKB:P55008] synonym: "Ionized calcium-binding adapter molecule 1" EXACT [UniProtKB:P55008] synonym: "Protein G1" EXACT [UniProtKB:P55008] xref: EMBL:AAA92457.1 xref: EMBL:AAB05003.1 xref: EMBL:AAD18087.1 xref: EMBL:AAH09474.1 xref: EMBL:BAA13088.1 xref: EMBL:BAB63392.1 xref: EMBL:CAA75062.1 xref: EMBL:CAI17694.1 xref: EMBL:CAI18308.1 xref: EMBL:CAI18495.1 xref: UniProtKB:P55008 xref: UniProtKB:Q9UKS9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004039 ! AIF1_human relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001675 name: CDN2D_HUMAN def: "Cyclin-dependent kinase 4 inhibitor D" [UniProtKB:P55273] synonym: "p19-INK4d" EXACT [UniProtKB:P55273] xref: EMBL:AAA85436.1 xref: EMBL:AAB03772.1 xref: EMBL:AAB18139.1 xref: EMBL:AAC27450.1 xref: EMBL:AAD02320.1 xref: EMBL:AAH01822.1 xref: EMBL:AAM54045.1 xref: EMBL:CAG46955.1 xref: UniProtKB:P55273 xref: UniProtKB:Q13102 xref: UniProtKB:Q6FGE9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004314 ! CDKN2D_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005779 ! cdk4-cdkn2d physical interaction relationship: participates_in CCO:I0005871 ! cdkn2d-tbc1d17 physical interaction relationship: participates_in CCO:I0006793 ! cdk6-cdkn2d-2 direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011128 ! CDN2D_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0001676 name: NH2L1_HUMAN def: "NHP2-like protein 1" [UniProtKB:P55769] synonym: "High mobility group-like nuclear protein 2 homolog 1" EXACT [UniProtKB:P55769] synonym: "hSNU13" EXACT [UniProtKB:P55769] synonym: "OTK27" EXACT [UniProtKB:P55769] synonym: "U4/U6.U5 tri-snRNP 15.5 kDa protein" EXACT [UniProtKB:P55769] xref: EMBL:AAC72945.1 xref: EMBL:AAF06959.1 xref: EMBL:AAH05358.1 xref: EMBL:AAH19282.1 xref: EMBL:BAA23363.1 xref: EMBL:CAB46207.1 xref: EMBL:CAG30417.1 xref: UniProtKB:P55769 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005193 ! NHP2L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008026 ! nhp2l1-cdkn2c physical interaction relationship: participates_in CCO:I0008283 ! nhp2l1-rif1 physical interaction relationship: transforms_into CCO:B0013173 ! NH2L1_HUMAN-N-acetylthreonine2 [Term] id: CCO:B0001679 name: HDAC4_HUMAN def: "Histone deacetylase 4" [UniProtKB:P56524] synonym: "EC 3.5.1.98" EXACT [UniProtKB:P56524] synonym: "HD4" EXACT [UniProtKB:P56524] xref: EMBL:AAD29046.1 xref: EMBL:BAA22957.2 xref: UniProtKB:P56524 xref: UniProtKB:Q9UND6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004789 ! HDAC4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006823 ! brms1-hdac4 physical interaction relationship: participates_in CCO:I0007192 ! hdac4-brms1 physical interaction relationship: participates_in CCO:I0007582 ! bcl6-hdac4 physical interaction relationship: participates_in CCO:I0007583 ! hdac4-bcl6 physical interaction relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012163 ! HDAC4_HUMAN-Phosphoserine246 relationship: transforms_into CCO:B0012164 ! HDAC4_HUMAN-Phosphoserine467 relationship: transforms_into CCO:B0012165 ! HDAC4_HUMAN-Phosphoserine632 [Term] id: CCO:B0001680 name: SN1L1_HUMAN def: "Serine/threonine-protein kinase SNF1-like kinase 1" [UniProtKB:P57059] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P57059] synonym: "Salt-inducible kinase 1" EXACT [UniProtKB:P57059] synonym: "Serine/threonine-protein kinase SNF1LK" EXACT [UniProtKB:P57059] synonym: "SIK-1" EXACT [UniProtKB:P57059] synonym: "SIK1" EXACT [UniProtKB:P57059] xref: EMBL:AAH38504.1 xref: EMBL:BAA95536.1 xref: EMBL:BAC85126.1 xref: EMBL:BAD74070.1 xref: UniProtKB:A6NC84 xref: UniProtKB:P57059 xref: UniProtKB:Q5R2V5 xref: UniProtKB:Q6ZNL8 xref: UniProtKB:Q86YJ2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005641 ! SNF1LK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006258 ! qsk-ywhaz-3 physical interaction relationship: participates_in CCO:I0007180 ! snf1lk-ywhaz-1 physical interaction relationship: participates_in CCO:I0007183 ! snf1lk-ywhaz-2 direct interaction relationship: participates_in CCO:I0007837 ! qsk-ywhaz-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000138 ! regulation of mitotic cell cycle relationship: transforms_into CCO:B0014128 ! SN1L1_HUMAN-Phosphothreonine182 relationship: transforms_into CCO:B0014129 ! SN1L1_HUMAN-Phosphoserine186 relationship: transforms_into CCO:B0014130 ! SN1L1_HUMAN-Phosphothreonine460 relationship: transforms_into CCO:B0014131 ! SN1L1_HUMAN-Phosphothreonine479 relationship: transforms_into CCO:B0014132 ! SN1L1_HUMAN-Phosphoserine578 [Term] id: CCO:B0001681 name: SESN2_HUMAN def: "Sestrin-2" [UniProtKB:P58004] synonym: "Hi95" EXACT [UniProtKB:P58004] xref: EMBL:AAH13304.1 xref: EMBL:AAH33719.1 xref: EMBL:AAM92261.1 xref: EMBL:BAB55438.1 xref: EMBL:CAB66486.1 xref: UniProtKB:P58004 xref: UniProtKB:Q96SI5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005594 ! SESN2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001682 name: SESN3_HUMAN def: "Sestrin-3" [UniProtKB:P58005] xref: EMBL:AAH17296.1 xref: EMBL:BAC04754.1 xref: UniProtKB:P58005 xref: UniProtKB:Q96AD1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005595 ! SESN3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001684 name: MLF1_HUMAN def: "Myeloid leukemia factor 1" [UniProtKB:P58340] synonym: "Myelodysplasia-myeloid leukemia factor 1" EXACT [UniProtKB:P58340] xref: EMBL:AAA99997.1 xref: EMBL:AAH07045.1 xref: UniProtKB:P58340 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005099 ! MLF1_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0004213 ! protein domain specific binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0005819 ! magea11-mlf1 physical interaction relationship: participates_in CCO:I0008407 ! mlf1-grik5 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001685 name: PTEN_HUMAN def: "Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN" [UniProtKB:P60484] synonym: "EC 3.1.3.16" EXACT [UniProtKB:P60484] synonym: "EC 3.1.3.48" EXACT [UniProtKB:P60484] synonym: "EC 3.1.3.67" EXACT [UniProtKB:P60484] synonym: "Mutated in multiple advanced cancers 1" EXACT [UniProtKB:P60484] synonym: "Phosphatase and tensin homolog" EXACT [UniProtKB:P60484] xref: EMBL:AAB66902.1 xref: EMBL:AAC08699.1 xref: EMBL:AAC51182.1 xref: EMBL:AAC51183.1 xref: EMBL:AAD13528.1 xref: EMBL:AAD38372.1 xref: EMBL:AAH05821.1 xref: EMBL:AAY57327.1 xref: EMBL:CAG29302.1 xref: UniProtKB:O00633 xref: UniProtKB:O02679 xref: UniProtKB:P60484 xref: UniProtKB:Q6ICT7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005396 ! PTEN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006324 ! pten-mast3-3 phosphorylation relationship: participates_in CCO:I0007572 ! pten-mast3-2 physical interaction relationship: participates_in CCO:I0007757 ! pten-mast3-1 physical interaction relationship: participates_in CCO:I0008301 ! pten-ang physical interaction relationship: participates_in CCO:I0008302 ! pten-chgb physical interaction relationship: participates_in CCO:I0008303 ! pten-cops6 physical interaction relationship: participates_in CCO:I0008304 ! pten-hba1 physical interaction relationship: participates_in CCO:I0008422 ! pten-utp14a physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013640 ! PTEN_HUMAN-Phosphothreonine366 relationship: transforms_into CCO:B0013641 ! PTEN_HUMAN-Phosphoserine370 relationship: transforms_into CCO:B0013642 ! PTEN_HUMAN-Phosphoserine385 relationship: transforms_into CCO:B0013643 ! PTEN_HUMAN-Phosphothreonine401 [Term] id: CCO:B0001686 name: CKS1_HUMAN def: "Cyclin-dependent kinases regulatory subunit 1" [UniProtKB:P61024] synonym: "CKS-1" EXACT [UniProtKB:P61024] xref: EMBL:AAH07751.1 xref: EMBL:AAH15629.1 xref: EMBL:AAH70319.1 xref: EMBL:AAH70320.1 xref: EMBL:AAK07518.1 xref: EMBL:AAK07553.1 xref: EMBL:AAP35860.1 xref: EMBL:CAA38702.1 xref: UniProtKB:P33551 xref: UniProtKB:P61024 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004364 ! CKS1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006747 ! dusp1-skp2-2 physical interaction relationship: participates_in CCO:I0007731 ! skp2-cks1-1 physical interaction relationship: participates_in CCO:I0007732 ! skp2-cks1-2 physical interaction relationship: participates_in CCO:I0007733 ! skp2-cks1-4 physical interaction relationship: participates_in CCO:I0007846 ! skp2-cks1-3 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001687 name: TGFB2_HUMAN def: "Transforming growth factor beta-2 precursor" [UniProtKB:P61812] synonym: "BSC-1 cell growth inhibitor" EXACT [UniProtKB:P61812] synonym: "Cetermin" EXACT [UniProtKB:P61812] synonym: "G-TSF" EXACT [UniProtKB:P61812] synonym: "Glioblastoma-derived T-cell suppressor factor" EXACT [UniProtKB:P61812] synonym: "Polyergin" EXACT [UniProtKB:P61812] synonym: "TGF-beta-2" EXACT [UniProtKB:P61812] xref: EMBL:AAA50404.1 xref: EMBL:AAA50405.1 xref: EMBL:AAA61162.1 xref: EMBL:AAH96235.1 xref: EMBL:AAH99635.1 xref: EMBL:AAR05442.1 xref: EMBL:CAA68279.1 xref: UniProtKB:P08112 xref: UniProtKB:P61812 xref: UniProtKB:Q15579 xref: UniProtKB:Q15581 xref: UniProtKB:Q4VAV9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005774 ! TGFB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006334 ! tgfb2-bapp-5 physical interaction relationship: participates_in CCO:I0006986 ! tgfb2-bapp-2 physical interaction relationship: participates_in CCO:I0006987 ! tgfb2-bapp-3 physical interaction relationship: participates_in CCO:I0007448 ! tgfb2-bapp-1 physical interaction relationship: participates_in CCO:I0007585 ! tgfb2-bapp-4 physical interaction relationship: participates_in CCO:I0007784 ! tgfb1-tgfb2-bapp-2 physical interaction relationship: participates_in CCO:P0000247 ! positive regulation of cell cycle [Term] id: CCO:B0001688 name: PP1A_HUMAN def: "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit" [UniProtKB:P62136] synonym: "EC 3.1.3.16" EXACT [UniProtKB:P62136] synonym: "PP-1A" EXACT [UniProtKB:P62136] xref: EMBL:AAA36475.1 xref: EMBL:AAA36508.1 xref: EMBL:AAH01888.1 xref: EMBL:AAH04482.1 xref: EMBL:AAH08010.1 xref: EMBL:AAP35275.1 xref: EMBL:CAA50197.1 xref: UniProtKB:P08129 xref: UniProtKB:P20653 xref: UniProtKB:P22802 xref: UniProtKB:P62136 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005356 ! PPP1CA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006379 ! map3k3-ppp1ca physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0041172 ! PP1A_HUMAN-Phosphothreonine320 [Term] id: CCO:B0001689 name: PP1B_HUMAN def: "Serine/threonine-protein phosphatase PP1-beta catalytic subunit" [UniProtKB:P62140] synonym: "EC 3.1.3.16" EXACT [UniProtKB:P62140] synonym: "PP-1B" EXACT [UniProtKB:P62140] xref: EMBL:AAA85093.1 xref: EMBL:AAF01137.1 xref: EMBL:AAH02697.1 xref: EMBL:AAH12045.1 xref: EMBL:AAV38549.1 xref: EMBL:AAY24124.1 xref: EMBL:CAA56870.1 xref: EMBL:CAG47059.1 xref: EMBL:CAG47080.1 xref: UniProtKB:P37140 xref: UniProtKB:P62140 xref: UniProtKB:Q5U087 xref: UniProtKB:Q6FG45 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005357 ! PPP1CB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006367 ! ikbkg-ppp1cb physical interaction relationship: participates_in CCO:I0006404 ! aah62584-ppp1cb physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013594 ! PP1B_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013595 ! PP1B_HUMAN-Phosphoserine41 relationship: transforms_into CCO:B0013596 ! PP1B_HUMAN-Phosphoserine47 [Term] id: CCO:B0001690 name: CALM_HUMAN def: "Calmodulin" [UniProtKB:P62158] synonym: "CaM" EXACT [UniProtKB:P62158] xref: EMBL:AAA35635.1 xref: EMBL:AAA35641.1 xref: EMBL:AAA51918.1 xref: EMBL:AAB60644.1 xref: EMBL:AAC83174.1 xref: EMBL:AAD45181.1 xref: EMBL:AAH00454.1 xref: EMBL:AAH03354.1 xref: EMBL:AAH05137.1 xref: EMBL:AAH06464.1 xref: EMBL:AAH08437.1 xref: EMBL:AAH08597.1 xref: EMBL:AAH11834.1 xref: EMBL:AAH17385.1 xref: EMBL:AAH18677.1 xref: EMBL:AAH26065.1 xref: EMBL:AAH47523.1 xref: EMBL:AAP35464.1 xref: EMBL:AAP35501.1 xref: EMBL:AAP88918.1 xref: EMBL:AAY24085.1 xref: EMBL:BAA08302.1 xref: EMBL:CAA36839.1 xref: EMBL:CAG46787.1 xref: EMBL:CAG46818.1 xref: UniProtKB:P02593 xref: UniProtKB:P62158 xref: UniProtKB:P70667 xref: UniProtKB:P99014 xref: UniProtKB:Q13942 xref: UniProtKB:Q53S29 xref: UniProtKB:Q61379 xref: UniProtKB:Q61380 xref: UniProtKB:Q96HK3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004214 ! CALM1_human relationship: encoded_by CCO:G0004215 ! CALM2_human relationship: encoded_by CCO:G0004216 ! CALM3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: transforms_into CCO:B0010909 ! CALM_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0010910 ! CALM_HUMAN-Phosphothreonine45 relationship: transforms_into CCO:B0010911 ! CALM_HUMAN-Phosphotyrosine100 relationship: transforms_into CCO:B0010912 ! CALM_HUMAN-N6,N6,N6-trimethyllysine116 [Term] id: CCO:B0001691 name: RS4X_HUMAN def: "40S ribosomal protein S4, X isoform" [UniProtKB:P62701] synonym: "SCR10" EXACT [UniProtKB:P62701] synonym: "Single copy abundant mRNA protein" EXACT [UniProtKB:P62701] xref: EMBL:AAA36597.1 xref: EMBL:AAA63255.1 xref: EMBL:AAB96968.1 xref: EMBL:AAH00472.1 xref: EMBL:AAH71662.1 xref: EMBL:AAI00904.1 xref: EMBL:AAI00905.1 xref: EMBL:CAA94808.1 xref: EMBL:CAG33016.1 xref: UniProtKB:P12631 xref: UniProtKB:P12750 xref: UniProtKB:P27576 xref: UniProtKB:P55831 xref: UniProtKB:P62701 xref: UniProtKB:Q14727 xref: UniProtKB:Q6IPY4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005537 ! RPS4X_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0008264 ! mcm2-rps4x physical interaction [Term] id: CCO:B0001692 name: RHOB_HUMAN def: "Rho-related GTP-binding protein RhoB precursor" [UniProtKB:P62745] synonym: "H6" EXACT [UniProtKB:P62745] xref: EMBL:AAA36565.1 xref: EMBL:AAH66954.1 xref: EMBL:AAM21118.1 xref: EMBL:AAV38353.1 xref: EMBL:AAV38354.1 xref: EMBL:AAY24345.1 xref: EMBL:CAA29968.1 xref: EMBL:CAG47068.1 xref: EMBL:DAA01138.1 xref: EMBL:DAA01912.1 xref: UniProtKB:P01121 xref: UniProtKB:P62745 xref: UniProtKB:Q5U0H6 xref: UniProtKB:Q7RTN5 xref: UniProtKB:Q7RTR9 xref: UniProtKB:Q9CUV7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005484 ! RHOB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013856 ! RHOB_HUMAN-ADP-ribosylasparagine41 relationship: transforms_into CCO:B0013857 ! RHOB_HUMAN-Cysteine methyl ester193 relationship: transforms_into CCO:B0031371 ! RHOB_HUMAN-Phosphotyrosine154 [Term] id: CCO:B0001693 name: RAN_HUMAN def: "GTP-binding nuclear protein Ran" [UniProtKB:P62826] synonym: "Androgen receptor-associated protein 24" EXACT [UniProtKB:P62826] synonym: "GTPase Ran" EXACT [UniProtKB:P62826] synonym: "Ras-like protein TC4" EXACT [UniProtKB:P62826] xref: EMBL:AAA36546.1 xref: EMBL:AAC05840.1 xref: EMBL:AAC99400.1 xref: EMBL:AAH04272.3 xref: EMBL:AAH14518.1 xref: EMBL:AAH14901.1 xref: EMBL:AAH16654.1 xref: EMBL:AAH51908.2 xref: EMBL:AAH72000.1 xref: EMBL:AAM15923.1 xref: EMBL:AAP35935.1 xref: EMBL:BAB93486.1 xref: EMBL:CAG29343.1 xref: UniProtKB:P17080 xref: UniProtKB:P28746 xref: UniProtKB:P28747 xref: UniProtKB:P62826 xref: UniProtKB:Q6IPB2 xref: UniProtKB:Q86V08 xref: UniProtKB:Q8NI90 xref: UniProtKB:Q9CSP3 xref: UniProtKB:Q9CWI7 xref: UniProtKB:Q9CZA2 xref: UniProtKB:Q9UDJ5 xref: UniProtKB:Q9UEU9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005425 ! RAN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006776 ! ran-ranbp1-1 physical interaction relationship: participates_in CCO:I0006777 ! ran-ranbp1-2 physical interaction relationship: participates_in CCO:I0006829 ! ran-xpot-1 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007153 ! ranbp3-ran-1 physical interaction relationship: participates_in CCO:I0007310 ! ran-tnpo1-1 direct interaction relationship: participates_in CCO:I0007471 ! ran-rcc1-1 direct interaction relationship: participates_in CCO:I0007861 ! cdn1b-kpna3-3 physical interaction relationship: participates_in CCO:I0007862 ! cdn1b-kpna5-5 physical interaction relationship: participates_in CCO:I0008307 ! ran-kiaa1377 physical interaction relationship: participates_in CCO:I0008494 ! ran-nefl physical interaction relationship: participates_in CCO:P0000068 ! mitotic spindle organization and biogenesis relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013707 ! RAN_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013708 ! RAN_HUMAN-Phosphotyrosine147 [Term] id: CCO:B0001694 name: RAP1A_HUMAN def: "Ras-related protein Rap-1A precursor" [UniProtKB:P62834] synonym: "C21KG" EXACT [UniProtKB:P62834] synonym: "G-22K" EXACT [UniProtKB:P62834] synonym: "GTP-binding protein smg-p21A" EXACT [UniProtKB:P62834] synonym: "Ras-related protein Krev-1" EXACT [UniProtKB:P62834] xref: EMBL:AAA36150.1 xref: EMBL:AAH14086.1 xref: EMBL:AAM12626.1 xref: EMBL:CAA31051.1 xref: EMBL:CAB55685.2 xref: UniProtKB:P10113 xref: UniProtKB:P62834 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005426 ! RAP1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006916 ! raf1-rap1a-1 direct interaction relationship: participates_in CCO:I0007002 ! rap1a-itgal-1 physical interaction relationship: participates_in CCO:I0007051 ! mit1a-ef1-fila physical interaction relationship: participates_in CCO:I0007163 ! raf1-rap1a-2 direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013709 ! RAP1A_HUMAN-Cysteine methyl ester181 [Term] id: CCO:B0001695 name: UBIQ_HUMAN def: "Ubiquitin" [UniProtKB:P62988] xref: EMBL:AAA36787.1 xref: EMBL:AAA36788.1 xref: EMBL:AAA36789.1 xref: EMBL:AAB21188.1 xref: EMBL:AAC25582.1 xref: EMBL:AAH00379.1 xref: EMBL:AAH09301.1 xref: EMBL:AAH15127.1 xref: EMBL:AAH26301.1 xref: EMBL:AAH31027.1 xref: EMBL:AAH39193.1 xref: EMBL:AAH46123.1 xref: EMBL:AAH66293.1 xref: EMBL:AAK31162.1 xref: EMBL:BAA09860.1 xref: EMBL:BAA23486.1 xref: EMBL:BAA23632.1 xref: EMBL:BAC56951.1 xref: EMBL:BAC56955.1 xref: EMBL:CAA28495.1 xref: EMBL:CAA40312.1 xref: EMBL:CAA40313.1 xref: EMBL:CAA40314.1 xref: EMBL:CAA44911.1 xref: UniProtKB:P02248 xref: UniProtKB:P02249 xref: UniProtKB:P02250 xref: UniProtKB:P62988 xref: UniProtKB:Q29120 xref: UniProtKB:Q6LBL4 xref: UniProtKB:Q6LDU5 xref: UniProtKB:Q91887 xref: UniProtKB:Q91888 xref: UniProtKB:Q9BWD6 xref: UniProtKB:Q9BX98 xref: UniProtKB:Q9UEF2 xref: UniProtKB:Q9UEG1 xref: UniProtKB:Q9UEK8 xref: UniProtKB:Q9UPK7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005863 ! RPS27A_human relationship: encoded_by CCO:G0005864 ! UBA52_human relationship: encoded_by CCO:G0005865 ! UBB_human relationship: encoded_by CCO:G0005866 ! UBC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006613 ! cdc6-ubiq-1 physical interaction relationship: participates_in CCO:I0006745 ! dusp1-ubiq-1 ubiquitination relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007149 ! dusp1-skp2-3 physical interaction relationship: transforms_into CCO:B0014565 ! UBIQ_HUMAN-Phosphoserine57 relationship: transforms_into CCO:B0014566 ! UBIQ_HUMAN-Phosphoserine65 [Term] id: CCO:B0001696 name: UBC9_HUMAN def: "SUMO-conjugating enzyme UBC9" [UniProtKB:P63279] synonym: "EC 6.3.2.-" EXACT [UniProtKB:P63279] synonym: "p18" EXACT [UniProtKB:P63279] synonym: "SUMO-protein ligase" EXACT [UniProtKB:P63279] synonym: "Ubiquitin carrier protein 9" EXACT [UniProtKB:P63279] synonym: "Ubiquitin carrier protein I" EXACT [UniProtKB:P63279] synonym: "Ubiquitin-conjugating enzyme E2 I" EXACT [UniProtKB:P63279] synonym: "Ubiquitin-protein ligase I" EXACT [UniProtKB:P63279] xref: EMBL:AAA86662.1 xref: EMBL:AAB02181.1 xref: EMBL:AAB09410.1 xref: EMBL:AAC50603.1 xref: EMBL:AAC50715.1 xref: EMBL:AAC50716.1 xref: EMBL:AAC51361.1 xref: EMBL:AAH00427.1 xref: EMBL:AAH04429.1 xref: EMBL:AAH51289.3 xref: EMBL:AAK61274.1 xref: EMBL:AAP35578.1 xref: EMBL:BAA08091.1 xref: EMBL:BAD92225.1 xref: EMBL:CAA05359.1 xref: EMBL:CAA65287.1 xref: EMBL:CAB45853.1 xref: UniProtKB:P50550 xref: UniProtKB:P63279 xref: UniProtKB:Q15698 xref: UniProtKB:Q59GX1 xref: UniProtKB:Q86VB3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005858 ! UBE2I_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005736 ! c14orf32-ube2i physical interaction relationship: participates_in CCO:I0005742 ! c18orf25-ube2i physical interaction relationship: participates_in CCO:I0005748 ! satb1-ube2i physical interaction relationship: participates_in CCO:I0005752 ! dach1-ube2i physical interaction relationship: participates_in CCO:I0005755 ! nudcd3-ube2i physical interaction relationship: participates_in CCO:I0005773 ! ube2i-znfn1a1 physical interaction relationship: participates_in CCO:I0005776 ! ripk2-ube2i physical interaction relationship: participates_in CCO:I0005788 ! pdlim7-ube2i physical interaction relationship: participates_in CCO:I0005795 ! ube2i-znf646 physical interaction relationship: participates_in CCO:I0005808 ! ube2i-znfn1a3 physical interaction relationship: participates_in CCO:I0005851 ! phc1-ube2i physical interaction relationship: participates_in CCO:I0005857 ! chmp4b-ube2i physical interaction relationship: participates_in CCO:I0005873 ! hgs-ube2i physical interaction relationship: participates_in CCO:I0005875 ! rad54b-ube2i physical interaction relationship: participates_in CCO:I0005876 ! ube2i-zbed1x physical interaction relationship: participates_in CCO:I0005901 ! trim29-ube2i physical interaction relationship: participates_in CCO:I0005920 ! hnrpc-ube2i physical interaction relationship: participates_in CCO:I0005928 ! ube2i-znf451 physical interaction relationship: participates_in CCO:I0005929 ! hnrpk-ube2i physical interaction relationship: participates_in CCO:I0005952 ! pias2-ube2i physical interaction relationship: participates_in CCO:I0005954 ! smad4-ube2i physical interaction relationship: participates_in CCO:I0006056 ! ap2g-ubc9-1 physical interaction relationship: participates_in CCO:I0006213 ! dnmt3b-ube2i-2 physical interaction relationship: participates_in CCO:I0006630 ! dnmt3b-ubl1-ube2i-1 physical interaction relationship: participates_in CCO:I0006789 ! uchl1-ube2i physical interaction relationship: participates_in CCO:I0006928 ! hnrpd-ube2i-2 physical interaction relationship: participates_in CCO:I0007173 ! dj_1-ubc9 physical interaction relationship: participates_in CCO:I0007287 ! dnmt3b-ube2i-1 physical interaction relationship: participates_in CCO:I0007316 ! bhlbh2-ube2i physical interaction relationship: participates_in CCO:I0007476 ! bhlbh2-ube2i-2 physical interaction relationship: participates_in CCO:I0007511 ! bhlbh2-ube2i-1 physical interaction relationship: participates_in CCO:I0007622 ! atxn1-ube2i physical interaction relationship: participates_in CCO:I0007823 ! hnrpd-ube2i physical interaction relationship: participates_in CCO:I0007918 ! ap2a-ubc9-1 physical interaction relationship: participates_in CCO:I0007919 ! ap2b-ubc9-1 physical interaction relationship: participates_in CCO:I0007920 ! ap2g-ubc9-2 physical interaction relationship: participates_in CCO:I0007921 ! ubc9-ap2a-1 physical interaction relationship: participates_in CCO:I0007922 ! ubc9-ap2b-1 physical interaction relationship: participates_in CCO:I0007923 ! ubc9-ap2g-1 physical interaction relationship: participates_in CCO:I0008184 ! ube2i-unc119 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001697 name: PP2AA_HUMAN def: "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform" [UniProtKB:P67775] synonym: "EC 3.1.3.16" EXACT [UniProtKB:P67775] synonym: "PP2A-alpha" EXACT [UniProtKB:P67775] synonym: "Replication protein C" EXACT [UniProtKB:P67775] synonym: "RP-C" EXACT [UniProtKB:P67775] xref: EMBL:AAA36466.1 xref: EMBL:AAB38019.1 xref: EMBL:AAH00400.1 xref: EMBL:AAH02657.1 xref: EMBL:AAH19275.1 xref: EMBL:AAH31696.1 xref: EMBL:CAA31176.1 xref: UniProtKB:P05323 xref: UniProtKB:P13197 xref: UniProtKB:P67775 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005359 ! PPP2CA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006758 ! sgol1-ppp2ca-1 physical interaction relationship: participates_in CCO:I0006761 ! sgol2-ppp2ca-1 physical interaction relationship: transforms_into CCO:B0013597 ! PP2AA_HUMAN-Phosphotyrosine307 relationship: transforms_into CCO:B0013598 ! PP2AA_HUMAN-Leucine methyl ester309 [Term] id: CCO:B0001698 name: MORN_HUMAN def: "Morphogenetic neuropeptide" [UniProtKB:P69208] synonym: "HA" EXACT [UniProtKB:P69208] synonym: "Head activator" EXACT [UniProtKB:P69208] xref: UniProtKB:P01163 xref: UniProtKB:P69208 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0001702 ! growth factor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012973 ! MORN_HUMAN-Pyrrolidone carboxylic acid1 [Term] id: CCO:B0001699 name: IF4G2_HUMAN def: "Eukaryotic translation initiation factor 4 gamma 2" [UniProtKB:P78344] synonym: "DAP-5" EXACT [UniProtKB:P78344] synonym: "Death-associated protein 5" EXACT [UniProtKB:P78344] synonym: "eIF-4-gamma 2" EXACT [UniProtKB:P78344] synonym: "eIF-4G 2" EXACT [UniProtKB:P78344] synonym: "eIF4G 2" EXACT [UniProtKB:P78344] synonym: "p97" EXACT [UniProtKB:P78344] xref: EMBL:AAB49973.1 xref: EMBL:AAC51166.1 xref: EMBL:AAH14930.2 xref: EMBL:AAH18975.1 xref: EMBL:AAH39851.1 xref: EMBL:AAI11416.1 xref: EMBL:BAB93515.1 xref: EMBL:BAD97268.1 xref: EMBL:CAA61857.1 xref: UniProtKB:O60877 xref: UniProtKB:P78344 xref: UniProtKB:P78404 xref: UniProtKB:Q0VH00 xref: UniProtKB:Q53EU1 xref: UniProtKB:Q58EZ2 xref: UniProtKB:Q8NI71 xref: UniProtKB:Q96C16 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004864 ! EIF4G2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006888 ! eif4g2-eif4a1-1 direct interaction relationship: participates_in CCO:I0007328 ! eif4gii-eif4aii physical interaction relationship: participates_in CCO:I0007603 ! eif4g2-eif4a1-2 direct interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0012333 ! IF4G2_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0012334 ! IF4G2_HUMAN-Phosphoserine395 relationship: transforms_into CCO:B0012335 ! IF4G2_HUMAN-Phosphothreonine508 [Term] id: CCO:B0001701 name: CCNA1_HUMAN def: "Cyclin-A1" [UniProtKB:P78396] xref: EMBL:AAB49754.1 xref: EMBL:AAB60863.1 xref: UniProtKB:P78396 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004242 ! CCNA1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0000754 ! microtubule cytoskeleton relationship: participates_in CCO:I0006020 ! orc1-cdk2-1 physical interaction relationship: participates_in CCO:I0006021 ! orc1-orc2-1 physical interaction relationship: participates_in CCO:I0006114 ! mcm6-ccna1 direct interaction relationship: participates_in CCO:I0006156 ! cdkn1a-ccna1 direct interaction relationship: participates_in CCO:I0006157 ! mcm4-ccna1 direct interaction relationship: participates_in CCO:I0007533 ! cdt1-cdk2-1 physical interaction relationship: participates_in CCO:I0007855 ! cdkn1a-ccna1-1 physical interaction relationship: participates_in CCO:I0007895 ! cyclina1_cdk1_human direct interaction relationship: participates_in CCO:I0007897 ! cyclina1_cdk2_human direct interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000132 ! male meiosis I [Term] id: CCO:B0001702 name: TXN4A_HUMAN def: "Thioredoxin-like protein 4A" [UniProtKB:P83876] synonym: "DIM1 protein homolog" EXACT [UniProtKB:P83876] synonym: "Spliceosomal U5 snRNP-specific 15 kDa protein" EXACT [UniProtKB:P83876] synonym: "Thioredoxin-like U5 snRNP protein U5-15kD" EXACT [UniProtKB:P83876] xref: EMBL:AAB81950.1 xref: EMBL:AAF17332.1 xref: EMBL:AAH01046.1 xref: EMBL:AAH19272.1 xref: UniProtKB:O14834 xref: UniProtKB:P83876 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005847 ! TXNL4A_human relationship: has_function CCO:F0004638 ! RNA splicing factor activity, transesterification mechanism relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000283 ! spliceosome relationship: participates_in CCO:I0005791 ! rhebl1-txnl4a physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001703 name: ERH_HUMAN def: "Enhancer of rudimentary homolog" [UniProtKB:P84090] xref: EMBL:AAC51172.1 xref: EMBL:AAH14301.1 xref: EMBL:AAH71709.1 xref: EMBL:AAP35523.1 xref: EMBL:BAA12865.1 xref: EMBL:CAG29294.1 xref: EMBL:CAG46975.1 xref: UniProtKB:P70659 xref: UniProtKB:P84090 xref: UniProtKB:Q14259 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004584 ! ERH_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007987 ! erh-tp53 physical interaction [Term] id: CCO:B0001706 name: FOXO4_HUMAN def: "Forkhead box protein O4" [UniProtKB:P98177] synonym: "Fork head domain transcription factor AFX1" EXACT [UniProtKB:P98177] xref: EMBL:AAA82171.1 xref: EMBL:AAI06762.1 xref: EMBL:AAL85197.1 xref: EMBL:CAA63819.1 xref: EMBL:CAA72156.1 xref: UniProtKB:O43821 xref: UniProtKB:P98177 xref: UniProtKB:Q13720 xref: UniProtKB:Q3KPF1 xref: UniProtKB:Q8TDK9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004656 ! FOXO4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0011890 ! FOXO4_HUMAN-Phosphothreonine32 relationship: transforms_into CCO:B0011891 ! FOXO4_HUMAN-Phosphoserine197 relationship: transforms_into CCO:B0011892 ! FOXO4_HUMAN-Phosphoserine262 relationship: transforms_into CCO:B0036005 ! FOXO4_HUMAN-Phosphoserine111 relationship: transforms_into CCO:B0036006 ! FOXO4_HUMAN-Phosphoserine200 [Term] id: CCO:B0001707 name: CDK3_HUMAN def: "Cell division protein kinase 3" [UniProtKB:Q00526] synonym: "EC 2.7.11.22" EXACT [UniProtKB:Q00526] xref: EMBL:AAV40830.1 xref: EMBL:CAA47001.1 xref: UniProtKB:Q00526 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004300 ! CDK3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011107 ! CDK3_HUMAN-Phosphothreonine14 relationship: transforms_into CCO:B0011108 ! CDK3_HUMAN-Phosphotyrosine15 relationship: transforms_into CCO:B0011109 ! CDK3_HUMAN-Phosphotyrosine19 relationship: transforms_into CCO:B0011110 ! CDK3_HUMAN-Phosphothreonine160 relationship: transforms_into CCO:B0011111 ! CDK3_HUMAN-Phosphoserine207 [Term] id: CCO:B0001708 name: CDK6_HUMAN def: "Cell division protein kinase 6" [UniProtKB:Q00534] synonym: "EC 2.7.11.22" EXACT [UniProtKB:Q00534] synonym: "Serine/threonine-protein kinase PLSTIRE" EXACT [UniProtKB:Q00534] xref: EMBL:AAH52264.1 xref: EMBL:AAM76970.1 xref: EMBL:CAA47008.1 xref: UniProtKB:Q00534 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004303 ! CDK6_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001060 ! cyclin-dependent protein kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006089 ! mcm2-cdk6 direct interaction relationship: participates_in CCO:I0006112 ! cdk6-cdkn2a direct interaction relationship: participates_in CCO:I0006119 ! mcm10-cdk6 direct interaction relationship: participates_in CCO:I0006131 ! cdk6-ccnd3 direct interaction relationship: participates_in CCO:I0006143 ! cdk6-ccnd1 direct interaction relationship: participates_in CCO:I0006148 ! cdkn1a-cdk6 direct interaction relationship: participates_in CCO:I0006608 ! cdk6-cdc37-1 physical interaction relationship: participates_in CCO:I0006646 ! cdk6-atxn1 physical interaction relationship: participates_in CCO:I0006792 ! cdk6-cdkn2a-1 direct interaction relationship: participates_in CCO:I0006793 ! cdk6-cdkn2d-2 direct interaction relationship: participates_in CCO:I0007393 ! cdk6-cdc37 physical interaction relationship: participates_in CCO:I0007905 ! cyclind3_cdk6_human direct interaction relationship: participates_in CCO:I0007906 ! cyclind1_cdk6_human direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011116 ! CDK6_HUMAN-Phosphotyrosine13 relationship: transforms_into CCO:B0011117 ! CDK6_HUMAN-Phosphotyrosine24 [Term] id: CCO:B0001709 name: CDK5_HUMAN def: "Cell division protein kinase 5" [UniProtKB:Q00535] synonym: "Cyclin-dependent kinase 5" EXACT [UniProtKB:Q00535] synonym: "EC 2.7.11.22" EXACT [UniProtKB:Q00535] synonym: "Serine/threonine-protein kinase PSSALRE" EXACT [UniProtKB:Q00535] synonym: "Tau protein kinase II catalytic subunit" EXACT [UniProtKB:Q00535] synonym: "TPKII catalytic subunit" EXACT [UniProtKB:Q00535] xref: EMBL:AAH05115.1 xref: EMBL:AAL15435.1 xref: EMBL:AAP35326.1 xref: EMBL:CAA47007.1 xref: UniProtKB:Q00535 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004302 ! CDK5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007828 ! cdk5-cdk5r1-1 direct interaction relationship: participates_in CCO:I0007829 ! cdk5-cdk5r1-2 direct interaction relationship: participates_in CCO:I0007830 ! cdk5-cdk5r1-3 direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011113 ! CDK5_HUMAN-Phosphothreonine14 relationship: transforms_into CCO:B0011114 ! CDK5_HUMAN-Phosphotyrosine15 relationship: transforms_into CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 [Term] id: CCO:B0001712 name: MDM2_HUMAN def: "E3 ubiquitin-protein ligase Mdm2" [UniProtKB:Q00987] synonym: "Double minute 2 protein" EXACT [UniProtKB:Q00987] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q00987] synonym: "Hdm2" EXACT [UniProtKB:Q00987] synonym: "Oncoprotein Mdm2" EXACT [UniProtKB:Q00987] synonym: "p53-binding protein Mdm2" EXACT [UniProtKB:Q00987] xref: EMBL:AAA60568.1 xref: EMBL:AAA75514.1 xref: EMBL:AAA75515.1 xref: EMBL:AAA75516.1 xref: EMBL:AAA75517.1 xref: EMBL:AAA75518.1 xref: EMBL:AAA82061.1 xref: EMBL:AAA82237.1 xref: EMBL:AAF42995.1 xref: EMBL:AAL40179.1 xref: EMBL:AAL40180.1 xref: EMBL:AAM78554.1 xref: EMBL:AAP35922.1 xref: EMBL:CAA78055.1 xref: EMBL:CAB64448.1 xref: UniProtKB:Q00987 xref: UniProtKB:Q13226 xref: UniProtKB:Q13297 xref: UniProtKB:Q13298 xref: UniProtKB:Q13299 xref: UniProtKB:Q13300 xref: UniProtKB:Q13301 xref: UniProtKB:Q53XW0 xref: UniProtKB:Q71TW9 xref: UniProtKB:Q8WYJ1 xref: UniProtKB:Q8WYJ2 xref: UniProtKB:Q9UGI3 xref: UniProtKB:Q9UMT8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005052 ! MDM2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006016 ! mdm2-mdm4-1 physical interaction relationship: participates_in CCO:I0006221 ! mdm2-daxx physical interaction relationship: participates_in CCO:I0006318 ! mdm2-npm1-4 physical interaction relationship: participates_in CCO:I0006527 ! mdm2-npm1-2 physical interaction relationship: participates_in CCO:I0006528 ! mdm2-npm1-6 physical interaction relationship: participates_in CCO:I0006926 ! p53-mdm2-2 physical interaction relationship: participates_in CCO:I0007099 ! mdm2-p53-1 direct interaction relationship: participates_in CCO:I0007339 ! mdm2-mdm4-2 physical interaction relationship: participates_in CCO:I0007340 ! mdm2-mdm4-3 physical interaction relationship: participates_in CCO:I0007407 ! mdm2-mdm4-4 physical interaction relationship: participates_in CCO:I0007753 ! mdm2-npm1-1 physical interaction relationship: participates_in CCO:I0007809 ! ubp7-daxx-8 physical interaction [Term] id: CCO:B0001713 name: E2F1_HUMAN def: "Transcription factor E2F1" [UniProtKB:Q01094] synonym: "E2F-1" EXACT [UniProtKB:Q01094] synonym: "PBR3" EXACT [UniProtKB:Q01094] synonym: "PRB-binding protein E2F-1" EXACT [UniProtKB:Q01094] synonym: "RBAP-1" EXACT [UniProtKB:Q01094] synonym: "RBBP-3" EXACT [UniProtKB:Q01094] synonym: "Retinoblastoma-associated protein 1" EXACT [UniProtKB:Q01094] synonym: "Retinoblastoma-binding protein 3" EXACT [UniProtKB:Q01094] xref: EMBL:AAA35782.1 xref: EMBL:AAB24289.1 xref: EMBL:AAC50719.1 xref: EMBL:AAD14150.1 xref: EMBL:AAH50369.1 xref: EMBL:AAH58902.1 xref: EMBL:AAM47604.1 xref: EMBL:CAC08486.1 xref: UniProtKB:Q01094 xref: UniProtKB:Q13143 xref: UniProtKB:Q92768 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004533 ! E2F1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006017 ! e2f1-trrap-1 physical interaction relationship: participates_in CCO:I0006055 ! pa2g4-e2f1-1 physical interaction relationship: participates_in CCO:I0007003 ! e2f3-rb physical interaction relationship: participates_in CCO:I0007008 ! e2f3-rb-1 physical interaction relationship: participates_in CCO:I0007009 ! e2f3-rb-2 physical interaction relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011620 ! E2F1_HUMAN-Phosphoserine375 [Term] id: CCO:B0001714 name: XPC_HUMAN def: "DNA-repair protein complementing XP-C cells" [UniProtKB:Q01831] synonym: "p125" EXACT [UniProtKB:Q01831] synonym: "Xeroderma pigmentosum group C-complementing protein" EXACT [UniProtKB:Q01831] xref: EMBL:AAF87574.1 xref: EMBL:AAH16620.1 xref: EMBL:AAM77801.1 xref: EMBL:BAA04651.1 xref: EMBL:BAD96564.1 xref: EMBL:CAA46158.1 xref: UniProtKB:Q01831 xref: UniProtKB:Q53GT7 xref: UniProtKB:Q96AX0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005939 ! XPC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006495 ! lsm3-xpc physical interaction relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: transforms_into CCO:B0014708 ! XPC_HUMAN-Phosphoserine94 relationship: transforms_into CCO:B0014709 ! XPC_HUMAN-Phosphoserine347 relationship: transforms_into CCO:B0014710 ! XPC_HUMAN-Phosphoserine351 relationship: transforms_into CCO:B0014711 ! XPC_HUMAN-Phosphoserine883 relationship: transforms_into CCO:B0014712 ! XPC_HUMAN-Phosphoserine884 relationship: transforms_into CCO:B0014713 ! XPC_HUMAN-Phosphoserine892 [Term] id: CCO:B0001715 name: CENPE_HUMAN def: "Centromeric protein E" [UniProtKB:Q02224] synonym: "CENP-E" EXACT [UniProtKB:Q02224] xref: EMBL:BAE06078.1 xref: EMBL:CAA78727.1 xref: EMBL:EAX06171.1 xref: UniProtKB:A6NKY9 xref: UniProtKB:Q02224 xref: UniProtKB:Q4LE75 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004324 ! CENPE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000019 ! mitotic metaphase relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000093 ! mitotic chromosome movement towards spindle pole relationship: participates_in CCO:P0000094 ! mitotic metaphase plate congression relationship: transforms_into CCO:B0011146 ! CENPE_HUMAN-Phosphothreonine422 relationship: transforms_into CCO:B0011147 ! CENPE_HUMAN-Phosphoserine454 relationship: transforms_into CCO:B0011148 ! CENPE_HUMAN-Phosphothreonine544 relationship: transforms_into CCO:B0011149 ! CENPE_HUMAN-Phosphoserine611 relationship: transforms_into CCO:B0011150 ! CENPE_HUMAN-Phosphoserine1211 relationship: transforms_into CCO:B0011151 ! CENPE_HUMAN-Phosphothreonine1268 relationship: transforms_into CCO:B0011152 ! CENPE_HUMAN-Phosphoserine2639 relationship: transforms_into CCO:B0011153 ! CENPE_HUMAN-Phosphoserine2651 relationship: transforms_into CCO:B0011154 ! CENPE_HUMAN-Phosphoserine2654 [Term] id: CCO:B0001716 name: KIF23_HUMAN def: "Kinesin-like protein KIF23" [UniProtKB:Q02241] synonym: "Kinesin-like protein 5" EXACT [UniProtKB:Q02241] synonym: "Mitotic kinesin-like protein 1" EXACT [UniProtKB:Q02241] xref: EMBL:AAH17705.2 xref: EMBL:AAH51826.1 xref: EMBL:CAA47628.2 xref: UniProtKB:Q02241 xref: UniProtKB:Q8WVP0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004944 ! KIF23_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000001 ! mitotic spindle elongation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012590 ! KIF23_HUMAN-Phosphotyrosine29 relationship: transforms_into CCO:B0012591 ! KIF23_HUMAN-Phosphoserine155 relationship: transforms_into CCO:B0012592 ! KIF23_HUMAN-Phosphoserine160 relationship: transforms_into CCO:B0012593 ! KIF23_HUMAN-Phosphothreonine450 relationship: transforms_into CCO:B0012594 ! KIF23_HUMAN-Phosphoserine682 relationship: transforms_into CCO:B0012595 ! KIF23_HUMAN-Phosphoserine684 relationship: transforms_into CCO:B0012596 ! KIF23_HUMAN-Phosphoserine686 relationship: transforms_into CCO:B0012597 ! KIF23_HUMAN-Phosphothreonine738 relationship: transforms_into CCO:B0012598 ! KIF23_HUMAN-Phosphoserine814 relationship: transforms_into CCO:B0012599 ! KIF23_HUMAN-Phosphoserine867 relationship: transforms_into CCO:B0012600 ! KIF23_HUMAN-Phosphoserine902 relationship: transforms_into CCO:B0012601 ! KIF23_HUMAN-Phosphoserine911 relationship: transforms_into CCO:B0012602 ! KIF23_HUMAN-Phosphoserine912 [Term] id: CCO:B0001719 name: NOTC2_HUMAN def: "Neurogenic locus notch homolog protein 2 precursor" [UniProtKB:Q04721] synonym: "hN2" EXACT [UniProtKB:Q04721] synonym: "Notch 2" EXACT [UniProtKB:Q04721] xref: EMBL:AAA36377.2 xref: EMBL:AAB19224.1 xref: EMBL:AAG37073.1 xref: UniProtKB:Q04721 xref: UniProtKB:Q99734 xref: UniProtKB:Q9H240 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005209 ! NOTCH2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0013238 ! NOTC2_HUMAN-Phosphothreonine1808 relationship: transforms_into CCO:B0013239 ! NOTC2_HUMAN-Phosphoserine1841 relationship: transforms_into CCO:B0013240 ! NOTC2_HUMAN-Phosphoserine1842 relationship: transforms_into CCO:B0013241 ! NOTC2_HUMAN-Phosphoserine1845 relationship: transforms_into CCO:B0013242 ! NOTC2_HUMAN-Phosphoserine2070 relationship: transforms_into CCO:B0013243 ! NOTC2_HUMAN-Phosphoserine2078 [Term] id: CCO:B0001720 name: ACVR1_HUMAN def: "Activin receptor type-1 precursor" [UniProtKB:Q04771] synonym: "Activin receptor type I" EXACT [UniProtKB:Q04771] synonym: "Activin receptor-like kinase 2" EXACT [UniProtKB:Q04771] synonym: "ACTR-I" EXACT [UniProtKB:Q04771] synonym: "ALK-2" EXACT [UniProtKB:Q04771] synonym: "EC 2.7.11.30" EXACT [UniProtKB:Q04771] synonym: "Serine/threonine-protein kinase receptor R1" EXACT [UniProtKB:Q04771] synonym: "SKR1" EXACT [UniProtKB:Q04771] synonym: "TGF-B superfamily receptor type I" EXACT [UniProtKB:Q04771] synonym: "TSR-I" EXACT [UniProtKB:Q04771] xref: EMBL:AAA36614.1 xref: EMBL:AAH33867.1 xref: EMBL:CAA80256.1 xref: UniProtKB:Q04771 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004025 ! ACVR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: transforms_into CCO:B0035985 ! ACVR1_HUMAN-Phosphoserine501 [Term] id: CCO:B0001721 name: RAD51_HUMAN def: "DNA repair protein RAD51 homolog 1" [UniProtKB:Q06609] synonym: "hRAD51" EXACT [UniProtKB:Q06609] synonym: "HsRAD51" EXACT [UniProtKB:Q06609] xref: EMBL:AAD49705.1 xref: EMBL:AAF69145.1 xref: EMBL:AAH01459.1 xref: EMBL:AAN87149.1 xref: EMBL:BAA02962.1 xref: EMBL:BAA03189.1 xref: EMBL:CAG38796.1 xref: UniProtKB:Q06609 xref: UniProtKB:Q6FHX9 xref: UniProtKB:Q9BV60 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005416 ! RAD51_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006002 ! rad51-brca2-1 physical interaction relationship: participates_in CCO:I0006676 ! rad51-rad51-2 colocalization relationship: participates_in CCO:I0006841 ! brca2-rad51-2 physical interaction relationship: participates_in CCO:I0006948 ! brca2-rad51-1 physical interaction relationship: participates_in CCO:I0007010 ! brca2-rad51-9 physical interaction relationship: participates_in CCO:I0007151 ! brca2-rad51-8 physical interaction relationship: participates_in CCO:I0007233 ! rad51-tp53-1 physical interaction relationship: participates_in CCO:I0007234 ! rad51-tp53-2 physical interaction relationship: participates_in CCO:I0007438 ! rad52-rad51-1 physical interaction relationship: participates_in CCO:I0007522 ! rad51-rad51-1 physical interaction relationship: participates_in CCO:I0007723 ! brca2-rad51-4 physical interaction relationship: participates_in CCO:I0007925 ! brca2-rad51-5 physical interaction relationship: participates_in CCO:I0007926 ! brca2-rad51-6 direct interaction relationship: participates_in CCO:I0007927 ! brca2-rad51-7 physical interaction relationship: participates_in CCO:I0007944 ! rad51-rad51-6 physical interaction relationship: participates_in CCO:I0007947 ! brca2-rad51-3 physical interaction relationship: participates_in CCO:I0008041 ! rad51-chd3 physical interaction relationship: participates_in CCO:I0008155 ! rad51-vim physical interaction relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000122 ! meiotic recombination relationship: transforms_into CCO:B0013669 ! RAD51_HUMAN-Phosphothreonine309 [Term] id: CCO:B0001722 name: KHDR1_HUMAN def: "KH domain-containing, RNA-binding, signal transduction-associated protein 1" [UniProtKB:Q07666] synonym: "GAP-associated tyrosine phosphoprotein p62" EXACT [UniProtKB:Q07666] synonym: "p21 Ras GTPase-activating protein-associated p62" EXACT [UniProtKB:Q07666] synonym: "p68" EXACT [UniProtKB:Q07666] synonym: "Sam68" EXACT [UniProtKB:Q07666] synonym: "Src-associated in mitosis 68 kDa protein" EXACT [UniProtKB:Q07666] xref: EMBL:AAA59990.1 xref: EMBL:AAB47504.1 xref: EMBL:AAH00717.1 xref: EMBL:AAH10132.1 xref: EMBL:AAH19109.1 xref: EMBL:BAC03643.1 xref: EMBL:CAH71944.1 xref: EMBL:CAH71945.1 xref: EMBL:CAI21971.1 xref: EMBL:CAI21972.1 xref: UniProtKB:Q07666 xref: UniProtKB:Q6PJX7 xref: UniProtKB:Q8NB97 xref: UniProtKB:Q99760 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004937 ! KHDRBS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006615 ! khdrbs1-ptpn6-1 physical interaction relationship: participates_in CCO:I0006616 ! khdrbs1-fyn-1 physical interaction relationship: participates_in CCO:I0006617 ! khdrbs1-plcg1-1 physical interaction relationship: participates_in CCO:I0006618 ! khdrbs1-grb2-1 physical interaction relationship: participates_in CCO:I0006619 ! khdrbs1-cbl-1 physical interaction relationship: participates_in CCO:I0006620 ! khdrbs1-jak3-1 physical interaction relationship: participates_in CCO:I0006621 ! khdrbs1-grb2-2 physical interaction relationship: participates_in CCO:I0006622 ! khdrbs1-jak3-2 physical interaction relationship: participates_in CCO:I0006623 ! khdrbs1-lck-1 physical interaction relationship: participates_in CCO:I0006712 ! khdrbs1-lyn-1 physical interaction relationship: participates_in CCO:I0006713 ! crebbp-khdrbs1-9 colocalization relationship: participates_in CCO:I0007088 ! khdrbs1-fyn-2 physical interaction relationship: participates_in CCO:I0007089 ! khdrbs1-fyn-3 physical interaction relationship: participates_in CCO:I0007330 ! hck-p62-1 physical interaction relationship: participates_in CCO:I0007346 ! khdrbs1-stat3-1 physical interaction relationship: participates_in CCO:I0007347 ! khdrbs1-stat3-2 physical interaction relationship: participates_in CCO:I0007477 ! smarca2-sam68 physical interaction relationship: participates_in CCO:I0007512 ! smarca2-sam68-1 physical interaction relationship: participates_in CCO:I0007519 ! lck-khdrbs1 physical interaction relationship: participates_in CCO:I0007964 ! hck-sam68-1 physical interaction relationship: participates_in CCO:I0007965 ! lck-sam68-1 physical interaction relationship: participates_in CCO:I0007966 ! grb2-sam68-1 physical interaction relationship: participates_in CCO:I0007967 ! grb2-sam68-2 physical interaction relationship: participates_in CCO:I0008166 ! src-khdrbs1 physical interaction relationship: participates_in CCO:I0008183 ! tubb4-khdrbs1 physical interaction relationship: participates_in CCO:I0008364 ! c2f-khdrbs1 physical interaction relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0012514 ! KHDR1_HUMAN-Phosphoserine18 relationship: transforms_into CCO:B0012515 ! KHDR1_HUMAN-Phosphoserine20 relationship: transforms_into CCO:B0012516 ! KHDR1_HUMAN-Phosphothreonine33 relationship: transforms_into CCO:B0012517 ! KHDR1_HUMAN-dimethylarginine45 relationship: transforms_into CCO:B0012518 ! KHDR1_HUMAN-dimethylarginine52 relationship: transforms_into CCO:B0012519 ! KHDR1_HUMAN-arginine291 relationship: transforms_into CCO:B0012520 ! KHDR1_HUMAN-dimethylarginine304 relationship: transforms_into CCO:B0012521 ! KHDR1_HUMAN-Omega-N-methylarginine310 relationship: transforms_into CCO:B0012522 ! KHDR1_HUMAN-Omega-N-methylarginine315 relationship: transforms_into CCO:B0012523 ! KHDR1_HUMAN-Omega-N-methylarginine320 relationship: transforms_into CCO:B0012524 ! KHDR1_HUMAN-Omega-N-methylarginine325 relationship: transforms_into CCO:B0012525 ! KHDR1_HUMAN-arginine331 relationship: transforms_into CCO:B0012526 ! KHDR1_HUMAN-Omega-N-methylarginine340 relationship: transforms_into CCO:B0012527 ! KHDR1_HUMAN-arginine346 relationship: transforms_into CCO:B0041154 ! KHDR1_HUMAN-Phosphoserine113 [Term] id: CCO:B0001723 name: BAX_HUMAN def: "Apoptosis regulator BAX" [UniProtKB:Q07812] xref: EMBL:AAA03619.1 xref: EMBL:AAA03620.1 xref: EMBL:AAA03621.1 xref: EMBL:AAC50142.1 xref: EMBL:AAD22706.1 xref: EMBL:AAF82094.1 xref: EMBL:AAH14175.1 xref: EMBL:AAO22992.1 xref: EMBL:CAD10744.1 xref: EMBL:EAW52418.1 xref: UniProtKB:P55269 xref: UniProtKB:Q07812 xref: UniProtKB:Q07814 xref: UniProtKB:Q07815 xref: UniProtKB:Q8WZ49 xref: UniProtKB:Q9NR76 xref: UniProtKB:Q9UQD6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004143 ! BAX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006207 ! bcl2-bax-2 physical interaction relationship: participates_in CCO:I0007343 ! bcl_xl-bax physical interaction relationship: participates_in CCO:I0007445 ! bax-bcl2-1 physical interaction relationship: participates_in CCO:I0007764 ! bak-bax-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001724 name: DPOE1_HUMAN def: "DNA polymerase epsilon catalytic subunit A" [UniProtKB:Q07864] synonym: "DNA polymerase II subunit A" EXACT [UniProtKB:Q07864] synonym: "EC 2.7.7.7" EXACT [UniProtKB:Q07864] xref: EMBL:AAA15448.1 xref: EMBL:AAA90924.1 xref: EMBL:AAC19148.1 xref: EMBL:AAP12650.1 xref: UniProtKB:Q07864 xref: UniProtKB:Q13533 xref: UniProtKB:Q86VH9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004505 ! POLE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007291 ! pole3-pole4-6 physical interaction relationship: participates_in CCO:I0007334 ! stk19-pole physical interaction relationship: participates_in CCO:I0007363 ! pole3-pole4-3 physical interaction relationship: participates_in CCO:I0007364 ! pole3-pole4-4 physical interaction relationship: participates_in CCO:I0007913 ! dpol-epsilon_human physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: transforms_into CCO:B0011577 ! DPOE1_HUMAN-Phosphoserine1940 [Term] id: CCO:B0001725 name: RBL2_HUMAN def: "Retinoblastoma-like protein 2" [UniProtKB:Q08999] synonym: "130 kDa retinoblastoma-associated protein" EXACT [UniProtKB:Q08999] synonym: "p130" EXACT [UniProtKB:Q08999] synonym: "PRB2" EXACT [UniProtKB:Q08999] synonym: "RBR-2" EXACT [UniProtKB:Q08999] xref: EMBL:AAB29227.1 xref: EMBL:AAC50479.1 xref: EMBL:CAA52671.1 xref: EMBL:CAA53661.1 xref: UniProtKB:Q08999 xref: UniProtKB:Q15073 xref: UniProtKB:Q16084 xref: UniProtKB:Q92812 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005446 ! RBL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013765 ! RBL2_HUMAN-Phosphoserine413 relationship: transforms_into CCO:B0013766 ! RBL2_HUMAN-Phosphothreonine417 relationship: transforms_into CCO:B0013767 ! RBL2_HUMAN-Phosphoserine639 relationship: transforms_into CCO:B0013768 ! RBL2_HUMAN-Phosphothreonine642 relationship: transforms_into CCO:B0013769 ! RBL2_HUMAN-Phosphoserine672 relationship: transforms_into CCO:B0013770 ! RBL2_HUMAN-Phosphoserine948 relationship: transforms_into CCO:B0013771 ! RBL2_HUMAN-Phosphoserine952 relationship: transforms_into CCO:B0013772 ! RBL2_HUMAN-Phosphoserine966 relationship: transforms_into CCO:B0013773 ! RBL2_HUMAN-Phosphoserine971 relationship: transforms_into CCO:B0013774 ! RBL2_HUMAN-Phosphoserine972 relationship: transforms_into CCO:B0013775 ! RBL2_HUMAN-Phosphoserine973 relationship: transforms_into CCO:B0013776 ! RBL2_HUMAN-Phosphothreonine974 relationship: transforms_into CCO:B0013777 ! RBL2_HUMAN-Phosphoserine981 relationship: transforms_into CCO:B0013778 ! RBL2_HUMAN-Phosphoserine982 relationship: transforms_into CCO:B0013779 ! RBL2_HUMAN-Phosphothreonine986 relationship: transforms_into CCO:B0036026 ! RBL2_HUMAN-Phosphothreonine1019 [Term] id: CCO:B0001726 name: DMWD_HUMAN def: "Dystrophia myotonica WD repeat-containing protein" [UniProtKB:Q09019] synonym: "DMR-N9 protein" EXACT [UniProtKB:Q09019] synonym: "Dystrophia myotonica-containing WD repeat motif protein" EXACT [UniProtKB:Q09019] synonym: "Protein 59" EXACT [UniProtKB:Q09019] xref: EMBL:AAA35767.1 xref: EMBL:AAC14447.1 xref: UniProtKB:Q09019 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004486 ! DMWD_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008469 ! dmwd-ppbp physical interaction relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0011546 ! DMWD_HUMAN-Phosphoserine530 [Term] id: CCO:B0001727 name: RBBP4_HUMAN def: "Histone-binding protein RBBP4" [UniProtKB:Q09028] synonym: "CAF-1 subunit C" EXACT [UniProtKB:Q09028] synonym: "CAF-I 48 kDa subunit" EXACT [UniProtKB:Q09028] synonym: "CAF-I p48" EXACT [UniProtKB:Q09028] synonym: "Chromatin assembly factor 1 subunit C" EXACT [UniProtKB:Q09028] synonym: "Chromatin assembly factor I p48 subunit" EXACT [UniProtKB:Q09028] synonym: "Nucleosome-remodeling factor subunit RBAP48" EXACT [UniProtKB:Q09028] synonym: "RBBP-4" EXACT [UniProtKB:Q09028] synonym: "Retinoblastoma-binding protein 4" EXACT [UniProtKB:Q09028] synonym: "Retinoblastoma-binding protein p48" EXACT [UniProtKB:Q09028] xref: EMBL:AAH03092.1 xref: EMBL:AAH15123.1 xref: EMBL:AAH53904.1 xref: EMBL:AAH75836.1 xref: EMBL:AAP35973.1 xref: EMBL:BAD96499.1 xref: EMBL:CAA50685.1 xref: EMBL:CAA52321.1 xref: UniProtKB:P31149 xref: UniProtKB:Q09028 xref: UniProtKB:Q53H02 xref: UniProtKB:Q96BV9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005438 ! RBBP4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: participates_in CCO:I0007869 ! hdac1-rbbp4-1 physical interaction relationship: participates_in CCO:I0008425 ! rbbp4-g22p1 physical interaction relationship: participates_in CCO:I0008502 ! rpn1-rbbp4 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013719 ! RBBP4_HUMAN-N-acetylalanine2 [Term] id: CCO:B0001728 name: EP300_HUMAN def: "Histone acetyltransferase p300" [UniProtKB:Q09472] synonym: "E1A-associated protein p300" EXACT [UniProtKB:Q09472] synonym: "EC 2.3.1.48" EXACT [UniProtKB:Q09472] xref: EMBL:AAA18639.1 xref: UniProtKB:Q09472 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004568 ! EP300_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006050 ! ep300-nap1l1-3 direct interaction relationship: participates_in CCO:I0006524 ! zbtb17-ep300 physical interaction relationship: participates_in CCO:I0006627 ! pparg-ep300 physical interaction relationship: participates_in CCO:I0006702 ! hif1a-ep300-3 physical interaction relationship: participates_in CCO:I0006721 ! p300-tfap2a-7 physical interaction relationship: participates_in CCO:I0006724 ! p300-tfap2a-2 physical interaction relationship: participates_in CCO:I0006725 ! p300-tfap2a-3 physical interaction relationship: participates_in CCO:I0006726 ! p300-tfap2a-4 physical interaction relationship: participates_in CCO:I0006727 ! p300-tfap2a-5 physical interaction relationship: participates_in CCO:I0006787 ! myc-ep300 physical interaction relationship: participates_in CCO:I0007084 ! p53-crebbp-3 physical interaction relationship: participates_in CCO:I0007146 ! p300-tfap2a-1 physical interaction relationship: participates_in CCO:I0007147 ! p300-cited2-1 physical interaction relationship: participates_in CCO:I0007150 ! cbp-atf3 physical interaction relationship: participates_in CCO:I0007361 ! p53-p300-1 physical interaction relationship: participates_in CCO:I0007417 ! p300-tfap2a-6 physical interaction relationship: participates_in CCO:I0007529 ! hif1a-ep300-2 physical interaction relationship: participates_in CCO:I0007787 ! ep300-nap1l1-4 physical interaction relationship: participates_in CCO:I0007788 ! ep300-nap1l1-5 physical interaction relationship: participates_in CCO:I0007954 ! hif1a-ep300-1 physical interaction relationship: participates_in CCO:I0007956 ! epas1-ep300-1 physical interaction relationship: participates_in CCO:I0008227 ! ep300-cops6 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011704 ! EP300_HUMAN-Omega-N-methylated arginine580 relationship: transforms_into CCO:B0011705 ! EP300_HUMAN-Omega-N-methylated arginine604 relationship: transforms_into CCO:B0011706 ! EP300_HUMAN-N6-acetyllysine1554 relationship: transforms_into CCO:B0011707 ! EP300_HUMAN-N6-acetyllysine1555 relationship: transforms_into CCO:B0011708 ! EP300_HUMAN-N6-acetyllysine1558 relationship: transforms_into CCO:B0011709 ! EP300_HUMAN-N6-acetyllysine1560 relationship: transforms_into CCO:B0011710 ! EP300_HUMAN-dimethylarginine2142 relationship: transforms_into CCO:B0011711 ! EP300_HUMAN-Citrulline2142 [Term] id: CCO:B0001729 name: CT069_HUMAN def: "Putative uncharacterized protein C20orf69" [UniProtKB:Q0VF47] xref: EMBL:AAI18989.1 xref: EMBL:AAI22538.1 xref: EMBL:CAC28313.1 xref: UniProtKB:Q0VF47 xref: UniProtKB:Q9BZ41 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005986 ! C20orf69_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001731 name: CETN1_HUMAN def: "Centrin-1" [UniProtKB:Q12798] synonym: "Caltractin isoform 2" EXACT [UniProtKB:Q12798] xref: EMBL:AAC27343.1 xref: EMBL:AAH29515.1 xref: UniProtKB:Q12798 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004332 ! CETN1_human relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000386 ! spindle pole body relationship: located_in CCO:C0000421 ! cytoskeleton relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000110 ! mitotic centrosome separation [Term] id: CCO:B0001732 name: SNF5_HUMAN def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1" [UniProtKB:Q12824] synonym: "BAF47" EXACT [UniProtKB:Q12824] synonym: "hSNF5" EXACT [UniProtKB:Q12824] synonym: "Integrase interactor 1 protein" EXACT [UniProtKB:Q12824] xref: EMBL:AAA81905.1 xref: EMBL:ABB02184.1 xref: EMBL:BAC77068.1 xref: EMBL:CAA09758.1 xref: EMBL:CAA09759.1 xref: EMBL:CAA76639.1 xref: EMBL:CAG30467.1 xref: UniProtKB:O75784 xref: UniProtKB:O95474 xref: UniProtKB:Q12824 xref: UniProtKB:Q38GA1 xref: UniProtKB:Q76N08 xref: UniProtKB:Q9UBH2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005644 ! SMARCB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006205 ! smarca4-pb1-arid2-1 physical interaction relationship: participates_in CCO:I0007258 ! smarcb1-arid2-1 physical interaction relationship: participates_in CCO:I0007259 ! arid2-pb1-1 physical interaction relationship: participates_in CCO:I0007260 ! brg1-baf250a-1 physical interaction relationship: participates_in CCO:I0007356 ! pb1-arid2-3 physical interaction relationship: participates_in CCO:I0007569 ! brg1-baf200-2 physical interaction relationship: participates_in CCO:I0007756 ! brg1-baf250a-2 physical interaction relationship: participates_in CCO:I0007876 ! brg1-baf200-1 physical interaction relationship: participates_in CCO:I0008206 ! ubqln4-smarcb1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0014136 ! SNF5_HUMAN-Phosphoserine129 [Term] id: CCO:B0001733 name: CDC20_HUMAN def: "Cell division cycle protein 20 homolog" [UniProtKB:Q12834] synonym: "p55CDC" EXACT [UniProtKB:Q12834] xref: EMBL:AAA19017.1 xref: EMBL:AAD16405.1 xref: EMBL:AAH00624.1 xref: EMBL:AAH01088.1 xref: EMBL:AAH06272.1 xref: EMBL:AAH09425.1 xref: EMBL:AAH09426.1 xref: EMBL:AAH10044.1 xref: EMBL:AAH12803.1 xref: EMBL:AAH12827.1 xref: EMBL:AAH13303.1 xref: EMBL:AAH15998.1 xref: EMBL:AAH24257.1 xref: EMBL:AAH31294.1 xref: EMBL:AAI10322.1 xref: EMBL:AAP36052.1 xref: EMBL:ABE96834.1 xref: EMBL:CAB92757.1 xref: UniProtKB:Q12834 xref: UniProtKB:Q5JUY4 xref: UniProtKB:Q9BW56 xref: UniProtKB:Q9UQI9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004284 ! CDC20_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0011058 ! CDC20_HUMAN-Phosphothreonine70 relationship: transforms_into CCO:B0011059 ! CDC20_HUMAN-Phosphothreonine106 [Term] id: CCO:B0001734 name: ILF3_HUMAN def: "Interleukin enhancer-binding factor 3" [UniProtKB:Q12906] synonym: "Double-stranded RNA-binding protein 76" EXACT [UniProtKB:Q12906] synonym: "DRBP76" EXACT [UniProtKB:Q12906] synonym: "M-phase phosphoprotein 4" EXACT [UniProtKB:Q12906] synonym: "MPP4" EXACT [UniProtKB:Q12906] synonym: "NF-AT-90" EXACT [UniProtKB:Q12906] synonym: "NFAR" EXACT [UniProtKB:Q12906] synonym: "Nuclear factor associated with dsRNA" EXACT [UniProtKB:Q12906] synonym: "Nuclear factor of activated T-cells 90 kDa" EXACT [UniProtKB:Q12906] synonym: "TCP80" EXACT [UniProtKB:Q12906] synonym: "Translational control protein 80" EXACT [UniProtKB:Q12906] xref: EMBL:AAA20994.1 xref: EMBL:AAC19152.1 xref: EMBL:AAD33966.1 xref: EMBL:AAD37575.1 xref: EMBL:AAD51098.1 xref: EMBL:AAD51099.1 xref: EMBL:AAF82685.1 xref: EMBL:AAF82686.1 xref: EMBL:AAF82687.1 xref: EMBL:AAH48314.1 xref: EMBL:AAH64836.1 xref: EMBL:AAK07424.1 xref: EMBL:AAK07425.1 xref: EMBL:CAA66917.1 xref: EMBL:CAA66918.1 xref: EMBL:CAC01121.1 xref: EMBL:CAC01122.1 xref: EMBL:CAC01123.1 xref: EMBL:CAC01124.1 xref: EMBL:CAC01404.1 xref: EMBL:CAC01405.1 xref: EMBL:CAC01406.1 xref: EMBL:CAC01407.1 xref: UniProtKB:O43409 xref: UniProtKB:Q12906 xref: UniProtKB:Q6P1X1 xref: UniProtKB:Q86XY7 xref: UniProtKB:Q99544 xref: UniProtKB:Q99545 xref: UniProtKB:Q9BZH4 xref: UniProtKB:Q9BZH5 xref: UniProtKB:Q9NQ95 xref: UniProtKB:Q9NQ96 xref: UniProtKB:Q9NQ97 xref: UniProtKB:Q9NQ98 xref: UniProtKB:Q9NQ99 xref: UniProtKB:Q9NQA0 xref: UniProtKB:Q9NQA1 xref: UniProtKB:Q9NQA2 xref: UniProtKB:Q9NRN2 xref: UniProtKB:Q9NRN3 xref: UniProtKB:Q9NRN4 xref: UniProtKB:Q9UMZ9 xref: UniProtKB:Q9UN00 xref: UniProtKB:Q9UN84 xref: UniProtKB:Q9UNA2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004884 ! ILF3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006991 ! hrmt1l2-ilf3-2 methylation relationship: participates_in CCO:I0007785 ! hrmt1l2-ilf3-3 physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:I0008251 ! ilf3-gdf9 physical interaction relationship: participates_in CCO:P0000039 ! M phase relationship: transforms_into CCO:B0012366 ! ILF3_HUMAN-Phosphoserine62 relationship: transforms_into CCO:B0012367 ! ILF3_HUMAN-Phosphoserine190 relationship: transforms_into CCO:B0012368 ! ILF3_HUMAN-Phosphoserine382 relationship: transforms_into CCO:B0012369 ! ILF3_HUMAN-Phosphoserine384 relationship: transforms_into CCO:B0012370 ! ILF3_HUMAN-Phosphoserine482 relationship: transforms_into CCO:B0012371 ! ILF3_HUMAN-Phosphothreonine592 relationship: transforms_into CCO:B0012372 ! ILF3_HUMAN-Omega-N-methylated arginine609 relationship: transforms_into CCO:B0012373 ! ILF3_HUMAN-Phosphoserine812 [Term] id: CCO:B0001735 name: FOXC1_HUMAN def: "Forkhead box protein C1" [UniProtKB:Q12948] synonym: "Forkhead-related protein FKHL7" EXACT [UniProtKB:Q12948] synonym: "Forkhead-related transcription factor 3" EXACT [UniProtKB:Q12948] synonym: "FREAC-3" EXACT [UniProtKB:Q12948] xref: EMBL:AAA92038.1 xref: EMBL:AAC18081.1 xref: EMBL:AAC72915.1 xref: EMBL:AAK13575.1 xref: EMBL:AAP15181.1 xref: EMBL:CAB81658.1 xref: UniProtKB:Q12948 xref: UniProtKB:Q86UP7 xref: UniProtKB:Q9BYM1 xref: UniProtKB:Q9NUE5 xref: UniProtKB:Q9UDD0 xref: UniProtKB:Q9UP06 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004654 ! FOXC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000258 ! negative regulation of mitotic cell cycle [Term] id: CCO:B0001736 name: DLG1_HUMAN def: "Disks large homolog 1" [UniProtKB:Q12959] synonym: "hDlg" EXACT [UniProtKB:Q12959] synonym: "SAP-97" EXACT [UniProtKB:Q12959] synonym: "Synapse-associated protein 97" EXACT [UniProtKB:Q12959] xref: EMBL:AAA50598.1 xref: EMBL:AAA50599.1 xref: UniProtKB:Q12958 xref: UniProtKB:Q12959 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004478 ! DLG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006386 ! map3k3-dlg1 physical interaction relationship: participates_in CCO:I0007135 ! dlg1-kif13b-3 physical interaction relationship: participates_in CCO:P0000188 ! G1/S transition checkpoint relationship: participates_in CCO:P0000258 ! negative regulation of mitotic cell cycle relationship: transforms_into CCO:B0011520 ! DLG1_HUMAN-Phosphoserine232 relationship: transforms_into CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 relationship: transforms_into CCO:B0011522 ! DLG1_HUMAN-Phosphothreonine683 relationship: transforms_into CCO:B0011523 ! DLG1_HUMAN-Phosphoserine684 relationship: transforms_into CCO:B0011524 ! DLG1_HUMAN-Phosphoserine687 relationship: transforms_into CCO:B0031311 ! DLG1_HUMAN-Phosphotyrosine399 [Term] id: CCO:B0001737 name: STRN3_HUMAN def: "Striatin-3" [UniProtKB:Q13033] synonym: "Cell-cycle autoantigen SG2NA" EXACT [UniProtKB:Q13033] synonym: "S/G2 antigen" EXACT [UniProtKB:Q13033] xref: EMBL:AAB81551.1 xref: EMBL:AAF81201.1 xref: UniProtKB:Q13033 xref: UniProtKB:Q9NRA5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005698 ! STRN3_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001647 ! calmodulin binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000244 ! membrane fraction relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0000766 ! membrane relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014268 ! STRN3_HUMAN-Phosphoserine229 [Term] id: CCO:B0001739 name: CDC16_HUMAN def: "Cell division cycle protein 16 homolog" [UniProtKB:Q13042] synonym: "Anaphase-promoting complex subunit 6" EXACT [UniProtKB:Q13042] synonym: "APC6" EXACT [UniProtKB:Q13042] synonym: "CDC16Hs" EXACT [UniProtKB:Q13042] synonym: "Cyclosome subunit 6" EXACT [UniProtKB:Q13042] xref: EMBL:AAC50200.1 xref: EMBL:AAD45156.1 xref: EMBL:AAH17244.1 xref: EMBL:AAS94323.1 xref: UniProtKB:Q13042 xref: UniProtKB:Q96AE6 xref: UniProtKB:Q9Y564 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004283 ! CDC16_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007929 ! cdc27-nek2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000099 ! regulation of mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0011052 ! CDC16_HUMAN-Phosphoserine112 relationship: transforms_into CCO:B0011053 ! CDC16_HUMAN-Phosphoserine490 relationship: transforms_into CCO:B0011054 ! CDC16_HUMAN-Phosphoserine560 relationship: transforms_into CCO:B0011055 ! CDC16_HUMAN-Phosphothreonine581 relationship: transforms_into CCO:B0011056 ! CDC16_HUMAN-Phosphoserine595 relationship: transforms_into CCO:B0011057 ! CDC16_HUMAN-Phosphothreonine599 [Term] id: CCO:B0001740 name: CSN1_HUMAN def: "COP9 signalosome complex subunit 1" [UniProtKB:Q13098] synonym: "G protein pathway suppressor 1" EXACT [UniProtKB:Q13098] synonym: "JAB1-containing signalosome subunit 1" EXACT [UniProtKB:Q13098] synonym: "Protein GPS1" EXACT [UniProtKB:Q13098] synonym: "Protein MFH" EXACT [UniProtKB:Q13098] synonym: "SGN1" EXACT [UniProtKB:Q13098] synonym: "Signalosome subunit 1" EXACT [UniProtKB:Q13098] xref: EMBL:AAC50906.2 xref: EMBL:AAH00155.3 xref: EMBL:AAH64503.1 xref: EMBL:AAP88836.1 xref: EMBL:BAC04120.1 xref: UniProtKB:Q13098 xref: UniProtKB:Q8NA10 xref: UniProtKB:Q9BWL1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004407 ! GPS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008479 ! gps1-tbc1d17 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011357 ! CSN1_HUMAN-Phosphoserine448 relationship: transforms_into CCO:B0011358 ! CSN1_HUMAN-Phosphoserine454 relationship: transforms_into CCO:B0011359 ! CSN1_HUMAN-Phosphothreonine459 relationship: transforms_into CCO:B0011360 ! CSN1_HUMAN-Phosphoserine463 relationship: transforms_into CCO:B0011361 ! CSN1_HUMAN-Phosphoserine468 [Term] id: CCO:B0001741 name: ZBT17_HUMAN def: "Zinc finger and BTB domain-containing protein 17" [UniProtKB:Q13105] synonym: "Miz-1" EXACT [UniProtKB:Q13105] synonym: "Myc-interacting zinc finger protein" EXACT [UniProtKB:Q13105] synonym: "Zinc finger protein 151" EXACT [UniProtKB:Q13105] synonym: "Zinc finger protein 60" EXACT [UniProtKB:Q13105] xref: EMBL:AAA61327.1 xref: EMBL:AAC50256.1 xref: EMBL:AAI26164.1 xref: EMBL:CAA70889.1 xref: EMBL:CAB85445.1 xref: EMBL:CAI19524.1 xref: UniProtKB:A0AV07 xref: UniProtKB:Q13105 xref: UniProtKB:Q15932 xref: UniProtKB:Q5JYB2 xref: UniProtKB:Q9NUC9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005952 ! ZBTB17_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006313 ! hcfc1-zbtb17-9 physical interaction relationship: participates_in CCO:I0006523 ! hcfc1-zbtb17-3 physical interaction relationship: participates_in CCO:I0006524 ! zbtb17-ep300 physical interaction relationship: participates_in CCO:I0006869 ! hcfc1-zbtb17-2 physical interaction relationship: participates_in CCO:I0007005 ! myc-zbtb17-1 physical interaction relationship: participates_in CCO:I0007006 ! myc-zbtb17-2 physical interaction relationship: participates_in CCO:I0007115 ! hcfc1-zbtb17-4 physical interaction relationship: participates_in CCO:I0007116 ! hcfc1-zbtb17-5 physical interaction relationship: participates_in CCO:I0007117 ! hcfc1-zbtb17-6 physical interaction relationship: participates_in CCO:I0007118 ! hcfc1-zbtb17-7 physical interaction relationship: participates_in CCO:I0007119 ! hcfc1-zbtb17-8 physical interaction relationship: participates_in CCO:I0007565 ! hcfc1-zbtb17-1 physical interaction relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001742 name: CAF1A_HUMAN def: "Chromatin assembly factor 1 subunit A" [UniProtKB:Q13111] synonym: "CAF-1 subunit A" EXACT [UniProtKB:Q13111] synonym: "CAF-I 150 kDa subunit" EXACT [UniProtKB:Q13111] synonym: "CAF-Ip150" EXACT [UniProtKB:Q13111] synonym: "Chromatin assembly factor I p150 subunit" EXACT [UniProtKB:Q13111] xref: EMBL:AAA76736.1 xref: EMBL:AAF04291.1 xref: EMBL:AAH52620.1 xref: UniProtKB:Q13111 xref: UniProtKB:Q7Z7K3 xref: UniProtKB:Q9UJY8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004212 ! CHAF1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005986 ! pcna-pold1-1 physical interaction relationship: participates_in CCO:I0005987 ! pcna-pold1-2 physical interaction relationship: participates_in CCO:I0006807 ! h3-caf1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0010891 ! CAF1A_HUMAN-Phosphoserine47 relationship: transforms_into CCO:B0010892 ! CAF1A_HUMAN-Phosphoserine123 relationship: transforms_into CCO:B0010893 ! CAF1A_HUMAN-Phosphoserine181 relationship: transforms_into CCO:B0010894 ! CAF1A_HUMAN-Phosphoserine185 relationship: transforms_into CCO:B0010895 ! CAF1A_HUMAN-Phosphoserine188 relationship: transforms_into CCO:B0010896 ! CAF1A_HUMAN-Phosphoserine237 relationship: transforms_into CCO:B0010897 ! CAF1A_HUMAN-Phosphothreonine241 relationship: transforms_into CCO:B0010898 ! CAF1A_HUMAN-Phosphoserine754 relationship: transforms_into CCO:B0010899 ! CAF1A_HUMAN-Phosphoserine933 [Term] id: CCO:B0001743 name: CAF1B_HUMAN def: "Chromatin assembly factor 1 subunit B" [UniProtKB:Q13112] synonym: "CAF-1 subunit B" EXACT [UniProtKB:Q13112] synonym: "CAF-I 60 kDa subunit" EXACT [UniProtKB:Q13112] synonym: "CAF-Ip60" EXACT [UniProtKB:Q13112] synonym: "Chromatin assembly factor I p60 subunit" EXACT [UniProtKB:Q13112] synonym: "M-phase phosphoprotein 7" EXACT [UniProtKB:Q13112] xref: EMBL:AAA76737.1 xref: EMBL:AAH21218.1 xref: EMBL:BAA89426.1 xref: EMBL:BAA95549.1 xref: EMBL:CAA66915.1 xref: UniProtKB:Q13112 xref: UniProtKB:Q99548 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004213 ! CHAF1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006807 ! h3-caf1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0010900 ! CAF1B_HUMAN-Phosphoserine429 relationship: transforms_into CCO:B0010901 ! CAF1B_HUMAN-Phosphoserine458 relationship: transforms_into CCO:B0010902 ! CAF1B_HUMAN-Phosphothreonine485 relationship: transforms_into CCO:B0010903 ! CAF1B_HUMAN-Phosphothreonine495 relationship: transforms_into CCO:B0010904 ! CAF1B_HUMAN-Phosphothreonine503 relationship: transforms_into CCO:B0010905 ! CAF1B_HUMAN-Phosphothreonine509 relationship: transforms_into CCO:B0010906 ! CAF1B_HUMAN-Phosphothreonine521 relationship: transforms_into CCO:B0010907 ! CAF1B_HUMAN-Phosphothreonine531 relationship: transforms_into CCO:B0010908 ! CAF1B_HUMAN-Phosphoserine538 [Term] id: CCO:B0001745 name: PSMD2_HUMAN def: "26S proteasome non-ATPase regulatory subunit 2" [UniProtKB:Q13200] synonym: "26S proteasome regulatory subunit RPN1" EXACT [UniProtKB:Q13200] synonym: "26S proteasome regulatory subunit S2" EXACT [UniProtKB:Q13200] synonym: "26S proteasome subunit p97" EXACT [UniProtKB:Q13200] synonym: "55.11 protein" EXACT [UniProtKB:Q13200] synonym: "Tumor necrosis factor type 1 receptor-associated protein 2" EXACT [UniProtKB:Q13200] xref: EMBL:AAA87705.1 xref: EMBL:AAH02368.1 xref: EMBL:AAH02997.1 xref: EMBL:AAH07897.1 xref: EMBL:BAA11226.1 xref: EMBL:CAA60167.1 xref: UniProtKB:Q12932 xref: UniProtKB:Q13200 xref: UniProtKB:Q15321 xref: UniProtKB:Q96I12 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005391 ! PSMD2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005870 ! psmd2-ublcp1 physical interaction relationship: participates_in CCO:I0005939 ! psmc1-psmd2 physical interaction relationship: participates_in CCO:I0006420 ! traf6-psmd2 physical interaction relationship: participates_in CCO:I0006606 ! cftr-ebp-1 physical interaction relationship: participates_in CCO:I0007988 ! psmd2-ptn physical interaction relationship: participates_in CCO:I0008038 ! psmd2-rif1 physical interaction relationship: participates_in CCO:I0008039 ! psmd2-unc119 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0013632 ! PSMD2_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0013633 ! PSMD2_HUMAN-Phosphoserine16 relationship: transforms_into CCO:B0013634 ! PSMD2_HUMAN-Phosphothreonine90 relationship: transforms_into CCO:B0013635 ! PSMD2_HUMAN-Phosphoserine361 [Term] id: CCO:B0001746 name: GPS2_HUMAN def: "G protein pathway suppressor 2" [UniProtKB:Q13227] synonym: "Protein GPS2" EXACT [UniProtKB:Q13227] xref: EMBL:AAB60432.1 xref: EMBL:AAH13652.1 xref: EMBL:CAB59255.1 xref: EMBL:CAB75677.2 xref: UniProtKB:Q13227 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004723 ! GPS2_human relationship: has_function CCO:F0001400 ! GTPase inhibitor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005723 ! atf4-gps2 physical interaction relationship: participates_in CCO:I0005914 ! gps2-tak1l physical interaction relationship: participates_in CCO:I0007891 ! tak1l-gps2 physical interaction relationship: participates_in CCO:I0008111 ! gps2-chd3 physical interaction relationship: participates_in CCO:I0008112 ! gps2-setdb1 physical interaction relationship: participates_in CCO:I0008176 ! pbk-gps2 physical interaction relationship: participates_in CCO:I0008234 ! flj20364-gps2 physical interaction relationship: participates_in CCO:I0008393 ! gps2-golga2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001748 name: MD2L1_HUMAN def: "Mitotic spindle assembly checkpoint protein MAD2A" [UniProtKB:Q13257] synonym: "HsMAD2" EXACT [UniProtKB:Q13257] synonym: "MAD2-like 1" EXACT [UniProtKB:Q13257] xref: EMBL:AAC50781.1 xref: EMBL:AAC52060.1 xref: EMBL:AAH00356.1 xref: EMBL:AAH05945.1 xref: EMBL:BAB63410.1 xref: EMBL:CAA03943.1 xref: UniProtKB:Q13257 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005048 ! MAD2L1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000103 ! kinetochore relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:I0005802 ! mad2l1-tsc22d4 physical interaction relationship: participates_in CCO:I0005960 ! mad1l1-mad2l1 physical interaction relationship: participates_in CCO:I0006415 ! tnfrsf1b-mad2l1 physical interaction relationship: participates_in CCO:I0006448 ! zwint_mad2l1_1 colocalization relationship: participates_in CCO:I0006988 ! adam17-mad2l1-1 physical interaction relationship: participates_in CCO:I0006989 ! adam17-mad2l1-3 physical interaction relationship: participates_in CCO:I0007360 ! adam17-mad2l1-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041159 ! MD2L1_HUMAN-N-acetylalanine2 [Term] id: CCO:B0001749 name: SKP2_HUMAN def: "S-phase kinase-associated protein 2" [UniProtKB:Q13309] synonym: "Cyclin A/CDK2-associated protein p45" EXACT [UniProtKB:Q13309] synonym: "F-box protein Skp2" EXACT [UniProtKB:Q13309] synonym: "F-box/LRR-repeat protein 1" EXACT [UniProtKB:Q13309] synonym: "p45skp2" EXACT [UniProtKB:Q13309] xref: EMBL:AAC50242.1 xref: EMBL:AAH01441.1 xref: EMBL:AAH07441.1 xref: EMBL:AAK31593.1 xref: EMBL:BAB87200.1 xref: EMBL:BAB87201.1 xref: EMBL:BAB87202.1 xref: UniProtKB:Q13309 xref: UniProtKB:Q8TDZ0 xref: UniProtKB:Q8TDZ1 xref: UniProtKB:Q9BV69 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005623 ! SKP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006197 ! orc1-skp2-2 physical interaction relationship: participates_in CCO:I0006695 ! cul1-skp1-1 physical interaction relationship: participates_in CCO:I0006746 ! dusp1-skp2-1 physical interaction relationship: participates_in CCO:I0006747 ! dusp1-skp2-2 physical interaction relationship: participates_in CCO:I0006767 ! skp1a-skp2-1 direct interaction relationship: participates_in CCO:I0006768 ! skp1a-skp2-2 direct interaction relationship: participates_in CCO:I0006769 ! skp1a-skp2-3 direct interaction relationship: participates_in CCO:I0006785 ! myc-skp2 physical interaction relationship: participates_in CCO:I0006797 ! cul1-cul1-7 physical interaction relationship: participates_in CCO:I0006863 ! cul1-skp1-5 physical interaction relationship: participates_in CCO:I0006864 ! cul1-skp2-2 physical interaction relationship: participates_in CCO:I0007105 ! cul1-skp2 physical interaction relationship: participates_in CCO:I0007110 ! cul1-skp1 physical interaction relationship: participates_in CCO:I0007111 ! cul1-skp1-4 physical interaction relationship: participates_in CCO:I0007112 ! cul1-skp2-1 physical interaction relationship: participates_in CCO:I0007149 ! dusp1-skp2-3 physical interaction relationship: participates_in CCO:I0007188 ! myc-skp2-1 physical interaction relationship: participates_in CCO:I0007533 ! cdt1-cdk2-1 physical interaction relationship: participates_in CCO:I0007537 ! orc1-skp2-1 physical interaction relationship: participates_in CCO:I0007731 ! skp2-cks1-1 physical interaction relationship: participates_in CCO:I0007732 ! skp2-cks1-2 physical interaction relationship: participates_in CCO:I0007733 ! skp2-cks1-4 physical interaction relationship: participates_in CCO:I0007846 ! skp2-cks1-3 physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: transforms_into CCO:B0014067 ! SKP2_HUMAN-Phosphoserine64 [Term] id: CCO:B0001750 name: ATM_HUMAN def: "Serine-protein kinase ATM" [UniProtKB:Q13315] synonym: "A-T, mutated" EXACT [UniProtKB:Q13315] synonym: "Ataxia telangiectasia mutated" EXACT [UniProtKB:Q13315] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q13315] xref: EMBL:AAA86520.1 xref: EMBL:AAB38309.1 xref: EMBL:AAB38310.1 xref: EMBL:AAB65827.1 xref: EMBL:AAC50289.1 xref: EMBL:AAC51298.1 xref: EMBL:AAO26044.1 xref: EMBL:CAA62603.1 xref: UniProtKB:O15429 xref: UniProtKB:Q12758 xref: UniProtKB:Q13315 xref: UniProtKB:Q16551 xref: UniProtKB:Q93007 xref: UniProtKB:Q9NP02 xref: UniProtKB:Q9UCX7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004117 ! ATM_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006252 ! atm-aatf-1 phosphorylation relationship: participates_in CCO:I0006256 ! atm-aatf-2 phosphorylation relationship: participates_in CCO:I0006960 ! mdc1-atm-1 physical interaction relationship: participates_in CCO:I0006962 ! nbs1-atm-1 physical interaction relationship: participates_in CCO:I0007696 ! atm-cabl-1 physical interaction relationship: participates_in CCO:I0007697 ! atm-pin2_trf1-1 physical interaction relationship: participates_in CCO:I0007698 ! pin2_trf1-atm-2 physical interaction relationship: participates_in CCO:I0007945 ! atm-aatf physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000105 ! mitotic cell cycle spindle assembly checkpoint relationship: participates_in CCO:P0000122 ! meiotic recombination relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0010653 ! ATM_HUMAN-Phosphothreonine72 relationship: transforms_into CCO:B0010654 ! ATM_HUMAN-Phosphoserine85 relationship: transforms_into CCO:B0010655 ! ATM_HUMAN-Phosphothreonine86 relationship: transforms_into CCO:B0010656 ! ATM_HUMAN-Phosphoserine367 relationship: transforms_into CCO:B0010657 ! ATM_HUMAN-Phosphothreonine373 relationship: transforms_into CCO:B0010658 ! ATM_HUMAN-Phosphoserine1981 relationship: transforms_into CCO:B0010659 ! ATM_HUMAN-Phosphothreonine1985 [Term] id: CCO:B0001751 name: CD5R2_HUMAN def: "Cyclin-dependent kinase 5 activator 2 precursor" [UniProtKB:Q13319] synonym: "CDK5 activator 2" EXACT [UniProtKB:Q13319] synonym: "Cyclin-dependent kinase 5 regulatory subunit 2" EXACT [UniProtKB:Q13319] synonym: "P39" EXACT [UniProtKB:Q13319] synonym: "P39I" EXACT [UniProtKB:Q13319] xref: EMBL:AAC50278.1 xref: EMBL:AAX88916.1 xref: EMBL:ABB96255.1 xref: UniProtKB:Q13319 xref: UniProtKB:Q4ZFW6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004281 ! CDK5R2_human relationship: has_function CCO:F0003202 ! cyclin-dependent protein kinase 5 activator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000803 ! cyclin-dependent protein kinase 5 activator complex relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity [Term] id: CCO:B0001753 name: TOP3A_HUMAN def: "DNA topoisomerase 3-alpha" [UniProtKB:Q13472] synonym: "DNA topoisomerase III alpha" EXACT [UniProtKB:Q13472] synonym: "EC 5.99.1.2" EXACT [UniProtKB:Q13472] xref: EMBL:AAB03694.1 xref: EMBL:AAB03695.1 xref: EMBL:AAH51748.1 xref: UniProtKB:Q13472 xref: UniProtKB:Q13473 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005812 ! TOP3A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007422 ! blm-c9orf76-2 physical interaction relationship: participates_in CCO:I0007427 ! c9orf76-blm-2 physical interaction relationship: participates_in CCO:I0007748 ! c9orf76-blm-1 physical interaction relationship: participates_in CCO:I0007749 ! blm-c9orf76-1 physical interaction relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0001755 name: PIN1_HUMAN def: "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1" [UniProtKB:Q13526] synonym: "EC 5.2.1.8" EXACT [UniProtKB:Q13526] synonym: "PPIase Pin1" EXACT [UniProtKB:Q13526] synonym: "Rotamase Pin1" EXACT [UniProtKB:Q13526] xref: EMBL:AAC50492.1 xref: EMBL:AAH02899.1 xref: EMBL:AAV38138.1 xref: EMBL:CAG28582.1 xref: UniProtKB:Q13526 xref: UniProtKB:Q53X75 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005316 ! PIN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005737 ! pin1-traf2 physical interaction relationship: participates_in CCO:I0005745 ! pin1-tsc22d4 physical interaction relationship: participates_in CCO:I0005749 ! pin1-rai1 physical interaction relationship: participates_in CCO:I0005757 ! gga2-pin1 physical interaction relationship: participates_in CCO:I0005778 ! pin1-zimp7 physical interaction relationship: participates_in CCO:I0005810 ! mdfi-pin1 physical interaction relationship: participates_in CCO:I0005874 ! hnrpc-pin1 physical interaction relationship: participates_in CCO:I0005881 ! pin1-rbpms physical interaction relationship: participates_in CCO:I0005891 ! pin1-rbbp8 physical interaction relationship: participates_in CCO:I0005915 ! nono-pin1 physical interaction relationship: participates_in CCO:I0006459 ! pin1-nek6-1 physical interaction relationship: participates_in CCO:I0006552 ! cdk2-pin1-3 physical interaction relationship: participates_in CCO:I0006642 ! pin1-ubqln4 physical interaction relationship: participates_in CCO:I0007509 ! pin1-nek6-2 physical interaction relationship: participates_in CCO:I0007510 ! pin1-nek6-3 colocalization relationship: participates_in CCO:I0008165 ! socs3-pin1 physical interaction relationship: participates_in CCO:I0008218 ! ddx24-pin1 physical interaction relationship: participates_in CCO:I0008259 ! lepr-pin1 physical interaction relationship: participates_in CCO:I0008353 ! klhlx-pin1 physical interaction relationship: participates_in CCO:I0008392 ! gpaa1-pin1 physical interaction relationship: participates_in CCO:I0008423 ! ptov1-pin1 physical interaction relationship: participates_in CCO:I0008447 ! zcchc10-pin1 physical interaction relationship: participates_in CCO:I0008462 ! css2-pin1 physical interaction relationship: participates_in CCO:I0008463 ! mtfr1-pin1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000099 ! regulation of mitosis relationship: transforms_into CCO:B0013514 ! PIN1_HUMAN-Phosphoserine108 [Term] id: CCO:B0001756 name: ATR_HUMAN def: "Serine/threonine-protein kinase ATR" [UniProtKB:Q13535] synonym: "Ataxia telangiectasia and Rad3-related protein" EXACT [UniProtKB:Q13535] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q13535] synonym: "FRAP-related protein 1" EXACT [UniProtKB:Q13535] xref: EMBL:AAC50405.1 xref: EMBL:AAC50929.1 xref: EMBL:AAK26749.1 xref: EMBL:CAA70298.1 xref: UniProtKB:Q13535 xref: UniProtKB:Q7KYL3 xref: UniProtKB:Q93051 xref: UniProtKB:Q9BXK4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004124 ! ATR_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006253 ! atr-aatf-2 phosphorylation relationship: participates_in CCO:I0006900 ! atr-tp53-1 phosphorylation relationship: participates_in CCO:I0006907 ! atr-creb1-1 phosphorylation relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0010709 ! ATR_HUMAN-Phosphoserine919 [Term] id: CCO:B0001758 name: ULA1_HUMAN def: "NEDD8-activating enzyme E1 regulatory subunit" [UniProtKB:Q13564] synonym: "Amyloid beta precursor protein-binding protein 1, 59 kDa" EXACT [UniProtKB:Q13564] synonym: "Amyloid protein-binding protein 1" EXACT [UniProtKB:Q13564] synonym: "APP-BP1" EXACT [UniProtKB:Q13564] synonym: "Proto-oncogene protein 1" EXACT [UniProtKB:Q13564] xref: EMBL:AAC23784.1 xref: EMBL:AAC50477.1 xref: EMBL:AAH00480.1 xref: EMBL:AAH13301.1 xref: EMBL:AAP35030.1 xref: EMBL:CAB66732.1 xref: UniProtKB:Q13564 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006428 ! NAE1_human relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0004164 ! NEDD8 activating enzyme activity relationship: has_function CCO:F0006299 ! protein heterodimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000246 ! insoluble fraction relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: participates_in CCO:I0005976 ! nedd8-tp53-1 neddylation relationship: participates_in CCO:I0007022 ! appbp1-nedd8-1 physical interaction relationship: participates_in CCO:I0007023 ! appbp1-nedd8-2 physical interaction relationship: participates_in CCO:I0008363 ! ubqln4-appbp1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000187 ! S-M checkpoint [Term] id: CCO:B0001759 name: CUL1_HUMAN def: "Cullin-1" [UniProtKB:Q13616] synonym: "CUL-1" EXACT [UniProtKB:Q13616] xref: EMBL:AAC36681.1 xref: EMBL:AAC50544.1 xref: EMBL:AAI25120.1 xref: EMBL:AAI25121.1 xref: EMBL:AAM49153.1 xref: EMBL:CAD97651.1 xref: UniProtKB:O60719 xref: UniProtKB:Q08AL6 xref: UniProtKB:Q13616 xref: UniProtKB:Q8IYW1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004421 ! CUL1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0004689 ! ubiquitin protein ligase binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001248 ! cullin-RING ubiquitin ligase complex relationship: participates_in CCO:I0006024 ! cul1-cand1 physical interaction relationship: participates_in CCO:I0006242 ! fbxo25-cul1-1 physical interaction relationship: participates_in CCO:I0006243 ! fbxo4-cul1-2 physical interaction relationship: participates_in CCO:I0006244 ! fbxo7-cul1-1 physical interaction relationship: participates_in CCO:I0006308 ! cul1-cand1-4 physical interaction relationship: participates_in CCO:I0006309 ! cul1-cand1-5 physical interaction relationship: participates_in CCO:I0006310 ! cul1-cand1-6 physical interaction relationship: participates_in CCO:I0006685 ! cul1-tip120a-1 physical interaction relationship: participates_in CCO:I0006688 ! cul1-tip120a-2 physical interaction relationship: participates_in CCO:I0006693 ! cul1-tip120a-3 physical interaction relationship: participates_in CCO:I0006694 ! cul1-tip120a-4 physical interaction relationship: participates_in CCO:I0006695 ! cul1-skp1-1 physical interaction relationship: participates_in CCO:I0006696 ! cul1-skp1-2 physical interaction relationship: participates_in CCO:I0006697 ! cul1-skp1-3 physical interaction relationship: participates_in CCO:I0006747 ! dusp1-skp2-2 physical interaction relationship: participates_in CCO:I0006796 ! cul1-rbx1-6 direct interaction relationship: participates_in CCO:I0006797 ! cul1-cul1-7 physical interaction relationship: participates_in CCO:I0006863 ! cul1-skp1-5 physical interaction relationship: participates_in CCO:I0006864 ! cul1-skp2-2 physical interaction relationship: participates_in CCO:I0006865 ! cand1-cul1-3 physical interaction relationship: participates_in CCO:I0006866 ! cul1-cand1-7 physical interaction relationship: participates_in CCO:I0006867 ! cul1-rbx1-5 physical interaction relationship: participates_in CCO:I0007105 ! cul1-skp2 physical interaction relationship: participates_in CCO:I0007106 ! cul1-cand1-1 physical interaction relationship: participates_in CCO:I0007107 ! cand1-cul1 physical interaction relationship: participates_in CCO:I0007108 ! cand1-cul1-1 physical interaction relationship: participates_in CCO:I0007109 ! cul1-cand1-2 physical interaction relationship: participates_in CCO:I0007110 ! cul1-skp1 physical interaction relationship: participates_in CCO:I0007111 ! cul1-skp1-4 physical interaction relationship: participates_in CCO:I0007112 ! cul1-skp2-1 physical interaction relationship: participates_in CCO:I0007113 ! cand1-cul1-4 physical interaction relationship: participates_in CCO:I0007114 ! cul1-cand1-8 physical interaction relationship: participates_in CCO:I0007254 ! cand1-cul1-2 physical interaction relationship: participates_in CCO:I0007504 ! cand1-cul1-5 physical interaction relationship: participates_in CCO:I0007943 ! fbxo11-skp1-1 physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0001760 name: CUL2_HUMAN def: "Cullin-2" [UniProtKB:Q13617] synonym: "CUL-2" EXACT [UniProtKB:Q13617] xref: EMBL:AAC50545.1 xref: EMBL:AAC51190.1 xref: EMBL:AAD23581.1 xref: EMBL:AAH09591.1 xref: EMBL:AAI10902.1 xref: EMBL:CAI13163.1 xref: UniProtKB:O00200 xref: UniProtKB:Q13617 xref: UniProtKB:Q5T2B6 xref: UniProtKB:Q9UNF9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004422 ! CUL2_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0004689 ! ubiquitin protein ligase binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001248 ! cullin-RING ubiquitin ligase complex relationship: participates_in CCO:I0006686 ! cul2-tip120a-2 physical interaction relationship: participates_in CCO:I0006689 ! cul2-tip120a-1 physical interaction relationship: participates_in CCO:I0007103 ! cul2-cand1 physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0011411 ! CUL2_HUMAN-Phosphotyrosine394 [Term] id: CCO:B0001761 name: CUL3_HUMAN def: "Cullin-3" [UniProtKB:Q13618] synonym: "CUL-3" EXACT [UniProtKB:Q13618] xref: EMBL:AAC28621.1 xref: EMBL:AAC36304.1 xref: EMBL:AAC36682.1 xref: EMBL:AAC50546.1 xref: EMBL:AAH31844.1 xref: EMBL:AAH39598.1 xref: EMBL:AAH92409.1 xref: EMBL:AAQ01660.1 xref: EMBL:BAA31592.2 xref: UniProtKB:O75415 xref: UniProtKB:Q13618 xref: UniProtKB:Q569L3 xref: UniProtKB:Q9UBI8 xref: UniProtKB:Q9UET7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004423 ! CUL3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006684 ! cul3-tip120a-2 physical interaction relationship: participates_in CCO:I0006690 ! cul3-tip120a-1 physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0011412 ! CUL3_HUMAN-Phosphotyrosine58 relationship: transforms_into CCO:B0011413 ! CUL3_HUMAN-Phosphoserine737 [Term] id: CCO:B0001762 name: CUL4A_HUMAN def: "Cullin-4A" [UniProtKB:Q13619] synonym: "CUL-4A" EXACT [UniProtKB:Q13619] xref: EMBL:AAC50547.1 xref: EMBL:AAD45191.1 xref: EMBL:AAH08308.2 xref: EMBL:AAR13072.1 xref: EMBL:BAA33146.1 xref: EMBL:BAD93235.1 xref: EMBL:CAI13795.1 xref: UniProtKB:O75834 xref: UniProtKB:Q13619 xref: UniProtKB:Q589T6 xref: UniProtKB:Q5TC62 xref: UniProtKB:Q6UP08 xref: UniProtKB:Q9UP17 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004424 ! CUL4A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006683 ! cul4a-tip120a-1 physical interaction relationship: participates_in CCO:I0006691 ! cul4a-tip120a-2 physical interaction relationship: participates_in CCO:I0006811 ! cul4a-ddb2 physical interaction relationship: participates_in CCO:I0006812 ! cul4a-cul4b physical interaction relationship: participates_in CCO:I0006813 ! cul4a-eed physical interaction relationship: participates_in CCO:I0006814 ! cul4a-cul4b-1 physical interaction relationship: participates_in CCO:I0006815 ! cul4a-cul4b-2 physical interaction relationship: participates_in CCO:I0006816 ! cul4a-cul4b-3 physical interaction relationship: participates_in CCO:I0006819 ! rbbp5-cul4a physical interaction relationship: participates_in CCO:I0007104 ! cul4a-cand1 physical interaction relationship: participates_in CCO:I0007514 ! h3_peptide-cul4a physical interaction relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: participates_in CCO:I0007717 ! cul4b-wdr5 physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0035996 ! CUL4A_HUMAN-Phosphotyrosine227 [Term] id: CCO:B0001763 name: CUL4B_HUMAN def: "Cullin-4B" [UniProtKB:Q13620] synonym: "CUL-4B" EXACT [UniProtKB:Q13620] xref: EMBL:AAB67315.1 xref: EMBL:AAC50548.1 xref: EMBL:AAH36216.1 xref: EMBL:AAK16812.1 xref: EMBL:AAR13073.1 xref: EMBL:BAA31670.2 xref: EMBL:CAD97843.1 xref: UniProtKB:Q13620 xref: UniProtKB:Q6PIE4 xref: UniProtKB:Q6UP07 xref: UniProtKB:Q7Z673 xref: UniProtKB:Q9BY37 xref: UniProtKB:Q9UEB7 xref: UniProtKB:Q9UED7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004425 ! CUL4B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006682 ! cul4b-tip120a-1 physical interaction relationship: participates_in CCO:I0006687 ! cul4b-tip120a-2 physical interaction relationship: participates_in CCO:I0006692 ! cul4b-tip120a-3 physical interaction relationship: participates_in CCO:I0006808 ! cul4b-ddb1-2 physical interaction relationship: participates_in CCO:I0006809 ! cul4b-tle2 physical interaction relationship: participates_in CCO:I0006810 ! ddb1-ddb2-1 physical interaction relationship: participates_in CCO:I0006812 ! cul4a-cul4b physical interaction relationship: participates_in CCO:I0006813 ! cul4a-eed physical interaction relationship: participates_in CCO:I0006814 ! cul4a-cul4b-1 physical interaction relationship: participates_in CCO:I0006815 ! cul4a-cul4b-2 physical interaction relationship: participates_in CCO:I0006816 ! cul4a-cul4b-3 physical interaction relationship: participates_in CCO:I0006817 ! l2dtl-cul4b physical interaction relationship: participates_in CCO:I0006818 ! tle2-ddb1-1 physical interaction relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: participates_in CCO:I0007717 ! cul4b-wdr5 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001764 name: ASPP2_HUMAN def: "Apoptosis-stimulating of p53 protein 2" [UniProtKB:Q13625] synonym: "53BP2" EXACT [UniProtKB:Q13625] synonym: "Bbp" EXACT [UniProtKB:Q13625] synonym: "Bcl2-binding protein" EXACT [UniProtKB:Q13625] synonym: "p53-binding protein 2" EXACT [UniProtKB:Q13625] synonym: "p53BP2" EXACT [UniProtKB:Q13625] synonym: "Renal carcinoma antigen NY-REN-51" EXACT [UniProtKB:Q13625] synonym: "Tumor suppressor p53-binding protein 2" EXACT [UniProtKB:Q13625] xref: EMBL:AAA21597.1 xref: EMBL:AAC50557.1 xref: EMBL:AAH46150.1 xref: EMBL:AAH58918.1 xref: EMBL:CAC83012.1 xref: UniProtKB:Q12892 xref: UniProtKB:Q13625 xref: UniProtKB:Q86X75 xref: UniProtKB:Q96KQ3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004110 ! TP53BP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006668 ! app-tp53bp2-2 physical interaction relationship: participates_in CCO:I0007284 ! app-tp53bp2-1 physical interaction relationship: participates_in CCO:I0007285 ! app-tp53bp2-3 physical interaction relationship: participates_in CCO:I0007467 ! tp53-tp53bp2-1 direct interaction relationship: participates_in CCO:I0007626 ! atxn7-tp53bp2 physical interaction relationship: participates_in CCO:I0008178 ! tp53bp2-eef1a1 physical interaction relationship: participates_in CCO:I0008179 ! tp53bp2-kif5a physical interaction relationship: participates_in CCO:I0008180 ! tp53bp2-ptn physical interaction relationship: participates_in CCO:I0008181 ! tp53bp2-utp14a physical interaction relationship: participates_in CCO:I0008182 ! tp53bp2-unc119 physical interaction relationship: participates_in CCO:I0008343 ! tp53bp2-mrpl20 physical interaction relationship: participates_in CCO:I0008442 ! tp53bp2-usp4 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0010631 ! ASPP2_HUMAN-Phosphoserine480 relationship: transforms_into CCO:B0010632 ! ASPP2_HUMAN-Phosphoserine698 [Term] id: CCO:B0001765 name: PTC1_HUMAN def: "Protein patched homolog 1" [UniProtKB:Q13635] synonym: "PTC" EXACT [UniProtKB:Q13635] synonym: "PTC1" EXACT [UniProtKB:Q13635] xref: EMBL:AAC50496.1 xref: EMBL:AAC50550.1 xref: EMBL:CAH73817.1 xref: UniProtKB:Q13463 xref: UniProtKB:Q13635 xref: UniProtKB:Q5VZC0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005395 ! PTCH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001766 name: RUNX3_HUMAN def: "Runt-related transcription factor 3" [UniProtKB:Q13761] synonym: "Acute myeloid leukemia 2 protein" EXACT [UniProtKB:Q13761] synonym: "CBF-alpha 3" EXACT [UniProtKB:Q13761] synonym: "Core-binding factor, alpha 3 subunit" EXACT [UniProtKB:Q13761] synonym: "Oncogene AML-2" EXACT [UniProtKB:Q13761] synonym: "PEA2-alpha C" EXACT [UniProtKB:Q13761] synonym: "PEBP2-alpha C" EXACT [UniProtKB:Q13761] synonym: "Polyomavirus enhancer-binding protein 2 alpha C subunit" EXACT [UniProtKB:Q13761] synonym: "SL3-3 enhancer factor 1 alpha C subunit" EXACT [UniProtKB:Q13761] synonym: "SL3/AKV core-binding factor alpha C subunit" EXACT [UniProtKB:Q13761] xref: EMBL:AAA86465.1 xref: EMBL:AAH13362.1 xref: EMBL:CAA18856.1 xref: EMBL:CAA56093.2 xref: EMBL:CAA84541.1 xref: UniProtKB:Q12969 xref: UniProtKB:Q13760 xref: UniProtKB:Q13761 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005547 ! RUNX3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006341 ! aml2-tle1-1 direct interaction relationship: participates_in CCO:I0006551 ! aml2-tle1-2 physical interaction relationship: participates_in CCO:I0007292 ! tle1-aml2-1 physical interaction relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001771 name: CD2L5_HUMAN def: "Cell division cycle 2-like protein kinase 5" [UniProtKB:Q14004] synonym: "CDC2-related protein kinase 5" EXACT [UniProtKB:Q14004] synonym: "Cholinesterase-related cell division controller" EXACT [UniProtKB:Q14004] synonym: "EC 2.7.11.22" EXACT [UniProtKB:Q14004] xref: EMBL:AAA58424.1 xref: EMBL:AAD54514.1 xref: EMBL:AAS07490.1 xref: EMBL:AAS07491.1 xref: EMBL:AAT74623.1 xref: EMBL:BAB47420.1 xref: EMBL:CAC10400.1 xref: EMBL:CAC10401.1 xref: UniProtKB:Q14004 xref: UniProtKB:Q6DKQ9 xref: UniProtKB:Q75MH4 xref: UniProtKB:Q75MH5 xref: UniProtKB:Q96JN4 xref: UniProtKB:Q9H4A0 xref: UniProtKB:Q9H4A1 xref: UniProtKB:Q9UDR4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004275 ! CDC2L5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006664 ! npm_alk-gak physical interaction relationship: participates_in CCO:P0000099 ! regulation of mitosis relationship: transforms_into CCO:B0011032 ! CD2L5_HUMAN-Phosphoserine315 relationship: transforms_into CCO:B0011033 ! CD2L5_HUMAN-Phosphoserine317 relationship: transforms_into CCO:B0011034 ! CD2L5_HUMAN-Phosphoserine325 relationship: transforms_into CCO:B0011035 ! CD2L5_HUMAN-Phosphoserine340 relationship: transforms_into CCO:B0011036 ! CD2L5_HUMAN-Phosphoserine342 relationship: transforms_into CCO:B0011037 ! CD2L5_HUMAN-Phosphoserine367 relationship: transforms_into CCO:B0011038 ! CD2L5_HUMAN-Phosphoserine383 relationship: transforms_into CCO:B0011039 ! CD2L5_HUMAN-Phosphoserine395 relationship: transforms_into CCO:B0011040 ! CD2L5_HUMAN-Phosphoserine397 relationship: transforms_into CCO:B0011041 ! CD2L5_HUMAN-Phosphoserine400 relationship: transforms_into CCO:B0011042 ! CD2L5_HUMAN-Phosphoserine436 relationship: transforms_into CCO:B0011043 ! CD2L5_HUMAN-Phosphoserine437 relationship: transforms_into CCO:B0011044 ! CD2L5_HUMAN-Phosphoserine439 relationship: transforms_into CCO:B0011045 ! CD2L5_HUMAN-Phosphoserine441 relationship: transforms_into CCO:B0011046 ! CD2L5_HUMAN-Phosphothreonine442 relationship: transforms_into CCO:B0011047 ! CD2L5_HUMAN-Phosphoserine1066 relationship: transforms_into CCO:B0011048 ! CD2L5_HUMAN-Phosphothreonine1246 [Term] id: CCO:B0001772 name: CKAP5_HUMAN def: "Cytoskeleton-associated protein 5" [UniProtKB:Q14008] synonym: "Ch-TOG protein" EXACT [UniProtKB:Q14008] synonym: "Colonic and hepatic tumor over-expressed protein" EXACT [UniProtKB:Q14008] xref: EMBL:BAA07892.2 xref: EMBL:CAA63212.1 xref: UniProtKB:Q14008 xref: UniProtKB:Q14668 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004363 ! CKAP5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006317 ! tacc1-chtog-8 colocalization relationship: participates_in CCO:I0006471 ! kiaa0387-kiaa0097 physical interaction relationship: participates_in CCO:I0007314 ! tacc1-ckap5 physical interaction relationship: participates_in CCO:I0007566 ! tacc1-chtog-6 direct interaction relationship: participates_in CCO:I0007871 ! tacc1-chtog-7 physical interaction relationship: participates_in CCO:P0000302 ! spindle pole body organization and biogenesis relationship: transforms_into CCO:B0011243 ! CKAP5_HUMAN-Phosphoserine816 [Term] id: CCO:B0001775 name: SEPT6_HUMAN def: "Septin-6" [UniProtKB:Q14141] xref: EMBL:AAH09291.1 xref: EMBL:AAH11922.3 xref: EMBL:AAH36240.1 xref: EMBL:AAK98547.1 xref: EMBL:AAK98548.1 xref: EMBL:AAK98549.1 xref: EMBL:AAK98550.1 xref: EMBL:AAK98551.1 xref: EMBL:BAA09477.1 xref: EMBL:CAI41426.1 xref: UniProtKB:Q14141 xref: UniProtKB:Q5JTK0 xref: UniProtKB:Q969W5 xref: UniProtKB:Q96A13 xref: UniProtKB:Q96GR1 xref: UniProtKB:Q96P86 xref: UniProtKB:Q96P87 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005589 ! SEPT6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005780 ! sept1-sept6 physical interaction relationship: participates_in CCO:I0005825 ! sept2-sept6 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013998 ! SEPT6_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013999 ! SEPT6_HUMAN-Phosphoserine408 relationship: transforms_into CCO:B0014000 ! SEPT6_HUMAN-Phosphoserine411 relationship: transforms_into CCO:B0014001 ! SEPT6_HUMAN-Phosphoserine416 relationship: transforms_into CCO:B0014002 ! SEPT6_HUMAN-Phosphothreonine418 [Term] id: CCO:B0001776 name: TFDP1_HUMAN def: "Transcription factor Dp-1" [UniProtKB:Q14186] synonym: "DRTF1" EXACT [UniProtKB:Q14186] synonym: "DRTF1-polypeptide 1" EXACT [UniProtKB:Q14186] synonym: "E2F dimerization partner 1" EXACT [UniProtKB:Q14186] xref: EMBL:AAA58440.1 xref: EMBL:AAH11685.1 xref: EMBL:AAN46090.1 xref: EMBL:CAI39789.1 xref: EMBL:EAX09216.1 xref: UniProtKB:Q14186 xref: UniProtKB:Q5JSB4 xref: UniProtKB:Q8IZL5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005768 ! TFDP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005860 ! e2f6-tfdp1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014346 ! TFDP1_HUMAN-Phosphoserine23 relationship: transforms_into CCO:B0036034 ! TFDP1_HUMAN-Phosphoserine183 [Term] id: CCO:B0001777 name: TFDP2_HUMAN def: "Transcription factor Dp-2" [UniProtKB:Q14188] synonym: "E2F dimerization partner 2" EXACT [UniProtKB:Q14188] xref: EMBL:AAA69016.1 xref: EMBL:AAB37321.1 xref: EMBL:AAB60378.1 xref: EMBL:AAC50642.1 xref: EMBL:AAH21113.1 xref: EMBL:AAR89905.1 xref: UniProtKB:Q13331 xref: UniProtKB:Q14187 xref: UniProtKB:Q14188 xref: UniProtKB:Q6R754 xref: UniProtKB:Q8WU88 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005769 ! TFDP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005947 ! e2f6-tfdp2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014347 ! TFDP2_HUMAN-Phosphoserine24 relationship: transforms_into CCO:B0014348 ! TFDP2_HUMAN-Phosphoserine42 [Term] id: CCO:B0001778 name: BTG3_HUMAN def: "Protein BTG3" [UniProtKB:Q14201] synonym: "Abundant in neuroepithelium area protein" EXACT [UniProtKB:Q14201] synonym: "Tob5 protein" EXACT [UniProtKB:Q14201] xref: EMBL:AAH11957.1 xref: EMBL:BAA33788.1 xref: UniProtKB:Q14201 xref: UniProtKB:Q96ET7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004196 ! BTG3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007619 ! atxn1-btg3 physical interaction relationship: participates_in CCO:I0007623 ! atxn1-btg3-1 physical interaction relationship: participates_in CCO:P0000258 ! negative regulation of mitotic cell cycle [Term] id: CCO:B0001779 name: DCTN1_HUMAN def: "Dynactin subunit 1" [UniProtKB:Q14203] synonym: "150 kDa dynein-associated polypeptide" EXACT [UniProtKB:Q14203] synonym: "DAP-150" EXACT [UniProtKB:Q14203] synonym: "DP-150" EXACT [UniProtKB:Q14203] synonym: "p135" EXACT [UniProtKB:Q14203] synonym: "p150-glued" EXACT [UniProtKB:Q14203] xref: EMBL:AAD03694.1 xref: EMBL:AAD55811.1 xref: EMBL:AAD55812.1 xref: EMBL:AAH06163.1 xref: EMBL:AAP35404.1 xref: EMBL:CAA67333.1 xref: UniProtKB:O95296 xref: UniProtKB:Q14203 xref: UniProtKB:Q9BRM9 xref: UniProtKB:Q9UIU1 xref: UniProtKB:Q9UIU2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004447 ! DCTN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006800 ! disc1-dctn1 physical interaction relationship: participates_in CCO:I0008466 ! dctn1-pgam1 physical interaction relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011452 ! DCTN1_HUMAN-Phosphoserine541 [Term] id: CCO:B0001780 name: DYHC1_HUMAN def: "Cytoplasmic dynein 1 heavy chain 1" [UniProtKB:Q14204] synonym: "Cytoplasmic dynein heavy chain 1" EXACT [UniProtKB:Q14204] synonym: "Dynein heavy chain, cytosolic" EXACT [UniProtKB:Q14204] xref: EMBL:AAA16065.1 xref: EMBL:AAB09727.1 xref: EMBL:AAH21297.1 xref: EMBL:AAT74625.1 xref: EMBL:BAA20783.3 xref: UniProtKB:Q14204 xref: UniProtKB:Q6DKQ7 xref: UniProtKB:Q8WU28 xref: UniProtKB:Q92814 xref: UniProtKB:Q9Y4G5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004526 ! DYNC1H1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006363 ! ikbkg-dnch1 physical interaction relationship: participates_in CCO:I0006579 ! disc1-dnch1 physical interaction relationship: participates_in CCO:I0006580 ! disc1-dnch1-2 physical interaction relationship: participates_in CCO:I0006801 ! disc1-dnch1-1 physical interaction relationship: participates_in CCO:P0000068 ! mitotic spindle organization and biogenesis relationship: transforms_into CCO:B0032842 ! DYHC1_HUMAN-Phosphoserine2410 relationship: transforms_into CCO:B0032843 ! DYHC1_HUMAN-Phosphotyrosine3379 relationship: transforms_into CCO:B0032844 ! DYHC1_HUMAN-Phosphothreonine4218 relationship: transforms_into CCO:B0032845 ! DYHC1_HUMAN-Phosphothreonine4221 relationship: transforms_into CCO:B0032846 ! DYHC1_HUMAN-Phosphoserine4368 [Term] id: CCO:B0001781 name: E2F2_HUMAN def: "Transcription factor E2F2" [UniProtKB:Q14209] synonym: "E2F-2" EXACT [UniProtKB:Q14209] xref: EMBL:AAA16890.1 xref: EMBL:AAH53676.1 xref: EMBL:AAM54044.1 xref: EMBL:CAA15949.1 xref: UniProtKB:Q14209 xref: UniProtKB:Q7Z6H1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004534 ! E2F2_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0000291 ! RNA polymerase II transcription factor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000272 ! transcription factor complex relationship: participates_in CCO:I0008361 ! bcar1-e2f2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001782 name: CASL_HUMAN def: "Enhancer of filamentation 1" [UniProtKB:Q14511] synonym: "CAS-L" EXACT [UniProtKB:Q14511] synonym: "CasL" EXACT [UniProtKB:Q14511] synonym: "CRK-associated substrate-related protein" EXACT [UniProtKB:Q14511] synonym: "HEF1" EXACT [UniProtKB:Q14511] synonym: "p105" EXACT [UniProtKB:Q14511] synonym: "Protein NEDD9" EXACT [UniProtKB:Q14511] synonym: "Renal carcinoma antigen NY-REN-12" EXACT [UniProtKB:Q14511] xref: EMBL:AAA98770.1 xref: EMBL:AAB53696.1 xref: EMBL:AAH40207.1 xref: UniProtKB:Q14511 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004221 ! NEDD9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0010924 ! CASL_HUMAN-Phosphotyrosine12 relationship: transforms_into CCO:B0010925 ! CASL_HUMAN-Phosphotyrosine92 relationship: transforms_into CCO:B0010926 ! CASL_HUMAN-Phosphotyrosine166 relationship: transforms_into CCO:B0010927 ! CASL_HUMAN-Phosphotyrosine177 relationship: transforms_into CCO:B0010928 ! CASL_HUMAN-Phosphotyrosine189 [Term] id: CCO:B0001783 name: HIC1_HUMAN def: "Hypermethylated in cancer 1 protein" [UniProtKB:Q14526] synonym: "Hic-1" EXACT [UniProtKB:Q14526] synonym: "Zinc finger and BTB domain-containing protein 29" EXACT [UniProtKB:Q14526] xref: EMBL:AAD09201.1 xref: UniProtKB:Q14526 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004805 ! HIC1_human relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0012189 ! HIC1_HUMAN-Phosphoserine313 relationship: transforms_into CCO:B0012190 ! HIC1_HUMAN-N6-acetyllysine333 [Term] id: CCO:B0001784 name: DMC1_HUMAN def: "Meiotic recombination protein DMC1/LIM15 homolog" [UniProtKB:Q14565] xref: EMBL:AAI25164.1 xref: EMBL:AAI25165.1 xref: EMBL:AAR89915.1 xref: EMBL:BAA09932.1 xref: EMBL:BAA10970.1 xref: EMBL:CAB45656.1 xref: EMBL:CAG30372.1 xref: UniProtKB:Q08AI1 xref: UniProtKB:Q14565 xref: UniProtKB:Q99498 xref: UniProtKB:Q9UH11 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004485 ! DMC1_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001707 ! DNA-dependent ATPase activity relationship: has_function CCO:F0003574 ! nucleoside-triphosphatase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000121 ! condensed nuclear chromosome relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001785 name: MCM6_HUMAN def: "DNA replication licensing factor MCM6" [UniProtKB:Q14566] synonym: "p105MCM" EXACT [UniProtKB:Q14566] xref: EMBL:AAB48165.1 xref: EMBL:AAC50766.1 xref: EMBL:AAH32374.1 xref: EMBL:AAO26043.1 xref: EMBL:BAA12699.1 xref: UniProtKB:Q13504 xref: UniProtKB:Q14566 xref: UniProtKB:Q99859 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005041 ! MCM6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005763 ! il1f5-mcm6 physical interaction relationship: participates_in CCO:I0005827 ! mcm6-psma1 physical interaction relationship: participates_in CCO:I0005833 ! mcm6-scnm1 physical interaction relationship: participates_in CCO:I0005883 ! ing5-mcm6 physical interaction relationship: participates_in CCO:I0005918 ! mcm6-mllt3 physical interaction relationship: participates_in CCO:I0005949 ! mcm2-mcm6 physical interaction relationship: participates_in CCO:I0005958 ! mcm6-mcm6-1 physical interaction relationship: participates_in CCO:I0005967 ! mcm6-smc1-1 physical interaction relationship: participates_in CCO:I0005968 ! mcm6-mcm7-1 physical interaction relationship: participates_in CCO:I0006081 ! orc6l-mcm6 direct interaction relationship: participates_in CCO:I0006085 ! mcm10-mcm6 direct interaction relationship: participates_in CCO:I0006103 ! mcm6-mcm6 direct interaction relationship: participates_in CCO:I0006114 ! mcm6-ccna1 direct interaction relationship: participates_in CCO:I0006121 ! mcm6-gmnn direct interaction relationship: participates_in CCO:I0006163 ! mcm3-mcm6 direct interaction relationship: participates_in CCO:I0007542 ! mcm4-mcm6-1 physical interaction relationship: participates_in CCO:I0007914 ! mcm2-7_human physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012836 ! MCM6_HUMAN-Phosphoserine271 relationship: transforms_into CCO:B0012837 ! MCM6_HUMAN-Phosphoserine762 relationship: transforms_into CCO:B0012838 ! MCM6_HUMAN-Phosphothreonine791 [Term] id: CCO:B0001786 name: Q14569_HUMAN def: "Putative uncharacterized protein" [UniProtKB:Q14569] xref: EMBL:AAB59556.1 xref: UniProtKB:Q14569 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0001702 ! growth factor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001787 name: ESPL1_HUMAN def: "Separin" [UniProtKB:Q14674] synonym: "Caspase-like protein ESPL1" EXACT [UniProtKB:Q14674] synonym: "EC 3.4.22.49" EXACT [UniProtKB:Q14674] synonym: "Extra spindle poles-like 1 protein" EXACT [UniProtKB:Q14674] synonym: "Separase" EXACT [UniProtKB:Q14674] xref: EMBL:AAR18247.1 xref: EMBL:BAA11482.2 xref: UniProtKB:Q14674 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004589 ! ESPL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation relationship: participates_in CCO:P0000225 ! establishment of mitotic spindle localization relationship: participates_in CCO:P0000253 ! positive regulation of mitotic metaphase/anaphase transition relationship: participates_in CCO:P0000254 ! negative regulation of sister chromatid cohesion relationship: transforms_into CCO:B0011766 ! ESPL1_HUMAN-Phosphoserine1126 relationship: transforms_into CCO:B0011767 ! ESPL1_HUMAN-Phosphoserine1508 [Term] id: CCO:B0001788 name: MDC1_HUMAN def: "Mediator of DNA damage checkpoint protein 1" [UniProtKB:Q14676] synonym: "Nuclear factor with BRCT domains 1" EXACT [UniProtKB:Q14676] xref: EMBL:BAA11487.2 xref: EMBL:BAB63322.1 xref: EMBL:BAC54931.1 xref: EMBL:CAH18685.1 xref: EMBL:CAI17440.1 xref: EMBL:CAI18195.1 xref: EMBL:CAI41890.1 xref: EMBL:CAI41891.1 xref: UniProtKB:Q14676 xref: UniProtKB:Q5JP55 xref: UniProtKB:Q5JP56 xref: UniProtKB:Q5ST83 xref: UniProtKB:Q68CQ3 xref: UniProtKB:Q86Z06 xref: UniProtKB:Q96QC2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005050 ! MDC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006960 ! mdc1-atm-1 physical interaction relationship: participates_in CCO:I0006961 ! nbs1-mdc1-1 physical interaction relationship: participates_in CCO:I0006962 ! nbs1-atm-1 physical interaction relationship: participates_in CCO:I0007131 ! terf2ip-rad50 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012848 ! MDC1_HUMAN-Phosphoserine168 relationship: transforms_into CCO:B0012849 ! MDC1_HUMAN-Phosphoserine329 relationship: transforms_into CCO:B0012850 ! MDC1_HUMAN-Phosphothreonine331 relationship: transforms_into CCO:B0012851 ! MDC1_HUMAN-Phosphoserine372 relationship: transforms_into CCO:B0012852 ! MDC1_HUMAN-Phosphoserine376 relationship: transforms_into CCO:B0012853 ! MDC1_HUMAN-Phosphothreonine378 relationship: transforms_into CCO:B0012854 ! MDC1_HUMAN-Phosphoserine402 relationship: transforms_into CCO:B0012855 ! MDC1_HUMAN-Phosphothreonine404 relationship: transforms_into CCO:B0012856 ! MDC1_HUMAN-Phosphoserine422 relationship: transforms_into CCO:B0012857 ! MDC1_HUMAN-Phosphoserine453 relationship: transforms_into CCO:B0012858 ! MDC1_HUMAN-Phosphothreonine455 relationship: transforms_into CCO:B0012859 ! MDC1_HUMAN-Phosphoserine495 relationship: transforms_into CCO:B0012860 ! MDC1_HUMAN-Phosphoserine498 relationship: transforms_into CCO:B0012861 ! MDC1_HUMAN-Phosphoserine513 relationship: transforms_into CCO:B0012862 ! MDC1_HUMAN-Phosphoserine516 relationship: transforms_into CCO:B0012863 ! MDC1_HUMAN-Phosphothreonine523 relationship: transforms_into CCO:B0012864 ! MDC1_HUMAN-Phosphothreonine652 relationship: transforms_into CCO:B0012865 ! MDC1_HUMAN-Phosphothreonine659 relationship: transforms_into CCO:B0012866 ! MDC1_HUMAN-Phosphoserine763 relationship: transforms_into CCO:B0012867 ! MDC1_HUMAN-Phosphothreonine765 relationship: transforms_into CCO:B0012868 ! MDC1_HUMAN-Phosphoserine780 relationship: transforms_into CCO:B0012869 ! MDC1_HUMAN-Phosphoserine882 relationship: transforms_into CCO:B0012870 ! MDC1_HUMAN-Phosphoserine955 relationship: transforms_into CCO:B0012871 ! MDC1_HUMAN-Phosphoserine964 relationship: transforms_into CCO:B0012872 ! MDC1_HUMAN-Phosphoserine986 relationship: transforms_into CCO:B0012873 ! MDC1_HUMAN-Phosphoserine988 relationship: transforms_into CCO:B0012874 ! MDC1_HUMAN-Phosphoserine995 relationship: transforms_into CCO:B0012875 ! MDC1_HUMAN-Phosphoserine1068 relationship: transforms_into CCO:B0012876 ! MDC1_HUMAN-Phosphoserine1086 relationship: transforms_into CCO:B0012877 ! MDC1_HUMAN-Phosphoserine1095 relationship: transforms_into CCO:B0012878 ! MDC1_HUMAN-Phosphothreonine1425 relationship: transforms_into CCO:B0012879 ! MDC1_HUMAN-Phosphoserine1430 relationship: transforms_into CCO:B0012880 ! MDC1_HUMAN-Phosphothreonine1461 relationship: transforms_into CCO:B0012881 ! MDC1_HUMAN-Phosphothreonine1623 relationship: transforms_into CCO:B0012882 ! MDC1_HUMAN-Phosphoserine1797 relationship: transforms_into CCO:B0012883 ! MDC1_HUMAN-Phosphoserine1814 relationship: transforms_into CCO:B0012884 ! MDC1_HUMAN-Phosphoserine1820 [Term] id: CCO:B0001789 name: KANK1_HUMAN def: "KN motif and ankyrin repeat domain-containing protein 1" [UniProtKB:Q14678] synonym: "Ankyrin repeat domain-containing protein 15" EXACT [UniProtKB:Q14678] synonym: "Kidney ankyrin repeat-containing protein" EXACT [UniProtKB:Q14678] xref: EMBL:AAH37495.1 xref: EMBL:BAA11489.2 xref: EMBL:CAH70388.1 xref: UniProtKB:Q14678 xref: UniProtKB:Q5W0W0 xref: UniProtKB:Q8IY65 xref: UniProtKB:Q8WX74 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0010894 ! KANK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001790 name: SMC1A_HUMAN def: "Structural maintenance of chromosomes protein 1A" [UniProtKB:Q14683] synonym: "Sb1.8" EXACT [UniProtKB:Q14683] synonym: "SMC1alpha protein" EXACT [UniProtKB:Q14683] xref: EMBL:AAB34405.1 xref: EMBL:AAI12128.1 xref: EMBL:BAA11495.2 xref: EMBL:CAI42089.1 xref: EMBL:CAI42646.1 xref: UniProtKB:O14995 xref: UniProtKB:Q14683 xref: UniProtKB:Q16351 xref: UniProtKB:Q2M228 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005625 ! SMC1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005964 ! smc1-mcm7-1 physical interaction relationship: participates_in CCO:I0005965 ! smc1-mcm7-3 physical interaction relationship: participates_in CCO:I0005966 ! mcm7-smc1-2 physical interaction relationship: participates_in CCO:I0005967 ! mcm6-smc1-1 physical interaction relationship: participates_in CCO:I0006227 ! smc1-mcm7-2 physical interaction relationship: participates_in CCO:I0006783 ! rad21-stag2 physical interaction relationship: participates_in CCO:I0006960 ! mdc1-atm-1 physical interaction relationship: participates_in CCO:I0007012 ! smc1-mcm7-4 direct interaction relationship: participates_in CCO:I0007013 ! smc1-mcm7-5 direct interaction relationship: participates_in CCO:I0007306 ! smc1-mcm7-6 physical interaction relationship: participates_in CCO:I0007307 ! smc1-rfc1-1 physical interaction relationship: participates_in CCO:I0007308 ! smc1-dpola-1 physical interaction relationship: participates_in CCO:I0007711 ! wapl-cspg6-4 physical interaction relationship: participates_in CCO:I0007712 ! wapl-cspg6-5 physical interaction relationship: participates_in CCO:I0007713 ! wapl-cspg6-6 physical interaction relationship: participates_in CCO:I0007714 ! wapl-cspg6-7 physical interaction relationship: participates_in CCO:I0007715 ! wapl-cspg6-9 physical interaction relationship: participates_in CCO:I0007821 ! mcm7-smc1-1 direct interaction relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000068 ! mitotic spindle organization and biogenesis relationship: participates_in CCO:P0000078 ! mitotic sister chromatid cohesion relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0014068 ! SMC1A_HUMAN-Phosphoserine358 relationship: transforms_into CCO:B0014069 ! SMC1A_HUMAN-Phosphoserine360 relationship: transforms_into CCO:B0014070 ! SMC1A_HUMAN-Phosphoserine951 relationship: transforms_into CCO:B0014071 ! SMC1A_HUMAN-Phosphoserine957 relationship: transforms_into CCO:B0014072 ! SMC1A_HUMAN-Phosphoserine962 relationship: transforms_into CCO:B0014073 ! SMC1A_HUMAN-Phosphoserine966 [Term] id: CCO:B0001792 name: KIF22_HUMAN def: "Kinesin-like protein KIF22" [UniProtKB:Q14807] synonym: "Kinesin-like DNA-binding protein" EXACT [UniProtKB:Q14807] synonym: "Kinesin-like protein 4" EXACT [UniProtKB:Q14807] xref: EMBL:AAH04352.1 xref: EMBL:AAH28155.1 xref: EMBL:AAP35923.1 xref: EMBL:BAA33019.2 xref: EMBL:BAA33063.1 xref: UniProtKB:O94814 xref: UniProtKB:Q14807 xref: UniProtKB:Q9BT46 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004943 ! KIF22_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008255 ! kif22-gdf9 physical interaction relationship: participates_in CCO:I0008256 ! kif22-immt physical interaction relationship: participates_in CCO:I0008257 ! kif22-pja1 physical interaction relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012586 ! KIF22_HUMAN-Phosphoserine452 relationship: transforms_into CCO:B0012587 ! KIF22_HUMAN-Phosphoserine543 relationship: transforms_into CCO:B0012588 ! KIF22_HUMAN-Phosphoserine562 relationship: transforms_into CCO:B0012589 ! KIF22_HUMAN-Phosphoserine581 [Term] id: CCO:B0001793 name: NOLC1_HUMAN def: "Nucleolar phosphoprotein p130" [UniProtKB:Q14978] synonym: "140 kDa nucleolar phosphoprotein" EXACT [UniProtKB:Q14978] synonym: "Nopp140" EXACT [UniProtKB:Q14978] synonym: "Nucleolar 130 kDa protein" EXACT [UniProtKB:Q14978] synonym: "Nucleolar and coiled-body phosphoprotein 1" EXACT [UniProtKB:Q14978] xref: EMBL:BAA04803.1 xref: EMBL:CAA84063.1 xref: UniProtKB:Q14978 xref: UniProtKB:Q15030 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005206 ! NOLC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013221 ! NOLC1_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0013222 ! NOLC1_HUMAN-Phosphoserine84 relationship: transforms_into CCO:B0013223 ! NOLC1_HUMAN-Phosphoserine85 relationship: transforms_into CCO:B0013224 ! NOLC1_HUMAN-Phosphoserine87 relationship: transforms_into CCO:B0013225 ! NOLC1_HUMAN-Phosphoserine90 relationship: transforms_into CCO:B0013226 ! NOLC1_HUMAN-Phosphoserine91 relationship: transforms_into CCO:B0013227 ! NOLC1_HUMAN-Phosphoserine397 relationship: transforms_into CCO:B0013228 ! NOLC1_HUMAN-Phosphoserine508 relationship: transforms_into CCO:B0013229 ! NOLC1_HUMAN-Phosphoserine538 relationship: transforms_into CCO:B0013230 ! NOLC1_HUMAN-Phosphoserine563 relationship: transforms_into CCO:B0013231 ! NOLC1_HUMAN-Phosphothreonine607 relationship: transforms_into CCO:B0013232 ! NOLC1_HUMAN-Phosphothreonine610 relationship: transforms_into CCO:B0013233 ! NOLC1_HUMAN-Phosphoserine623 relationship: transforms_into CCO:B0013234 ! NOLC1_HUMAN-Phosphoserine643 relationship: transforms_into CCO:B0013235 ! NOLC1_HUMAN-Phosphoserine698 [Term] id: CCO:B0001794 name: NUMA1_HUMAN def: "Nuclear mitotic apparatus protein 1" [UniProtKB:Q14980] synonym: "NuMA protein" EXACT [UniProtKB:Q14980] synonym: "SP-H antigen" EXACT [UniProtKB:Q14980] xref: EMBL:CAA77669.1 xref: EMBL:CAA77670.1 xref: UniProtKB:Q14980 xref: UniProtKB:Q14981 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005225 ! NUMA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006311 ! numa1-gpsm2-1 physical interaction relationship: participates_in CCO:I0006312 ! numa1-gnai1-1 physical interaction relationship: participates_in CCO:I0006665 ! npm_alk-cdc14 physical interaction relationship: participates_in CCO:I0006966 ! gnai1-numa1-1 physical interaction relationship: participates_in CCO:I0006967 ! gnai1-gpsm2-3 physical interaction relationship: participates_in CCO:I0006968 ! gpsm2-numa1-1 physical interaction relationship: participates_in CCO:I0007255 ! gpsm2-numa1-3 physical interaction relationship: participates_in CCO:I0007421 ! gpsm2-numa1-2 physical interaction relationship: participates_in CCO:I0007747 ! gnai1-gpsm2-2 physical interaction relationship: participates_in CCO:I0007750 ! gpsm2-numa1-4 physical interaction relationship: participates_in CCO:P0000020 ! mitotic anaphase relationship: transforms_into CCO:B0013293 ! NUMA1_HUMAN-Phosphoserine169 relationship: transforms_into CCO:B0013294 ! NUMA1_HUMAN-Phosphoserine172 relationship: transforms_into CCO:B0013295 ! NUMA1_HUMAN-Phosphoserine200 relationship: transforms_into CCO:B0013296 ! NUMA1_HUMAN-Phosphoserine203 relationship: transforms_into CCO:B0013297 ! NUMA1_HUMAN-Phosphothreonine211 relationship: transforms_into CCO:B0013298 ! NUMA1_HUMAN-Phosphoserine388 relationship: transforms_into CCO:B0013299 ! NUMA1_HUMAN-Phosphoserine395 relationship: transforms_into CCO:B0013300 ! NUMA1_HUMAN-Phosphoserine820 relationship: transforms_into CCO:B0013301 ! NUMA1_HUMAN-Phosphothreonine963 relationship: transforms_into CCO:B0013302 ! NUMA1_HUMAN-Phosphoserine1262 relationship: transforms_into CCO:B0013303 ! NUMA1_HUMAN-Phosphoserine1601 relationship: transforms_into CCO:B0013304 ! NUMA1_HUMAN-Phosphoserine1721 relationship: transforms_into CCO:B0013305 ! NUMA1_HUMAN-Phosphoserine1724 relationship: transforms_into CCO:B0013306 ! NUMA1_HUMAN-Phosphoserine1728 relationship: transforms_into CCO:B0013307 ! NUMA1_HUMAN-Phosphothreonine1733 relationship: transforms_into CCO:B0013308 ! NUMA1_HUMAN-Phosphoserine1757 relationship: transforms_into CCO:B0013309 ! NUMA1_HUMAN-Phosphoserine1760 relationship: transforms_into CCO:B0013310 ! NUMA1_HUMAN-Phosphoserine1769 relationship: transforms_into CCO:B0013311 ! NUMA1_HUMAN-Phosphoserine1772 relationship: transforms_into CCO:B0013312 ! NUMA1_HUMAN-Phosphotyrosine1774 relationship: transforms_into CCO:B0013313 ! NUMA1_HUMAN-Phosphothreonine1776 relationship: transforms_into CCO:B0013314 ! NUMA1_HUMAN-Phosphoserine1830 relationship: transforms_into CCO:B0013315 ! NUMA1_HUMAN-Phosphoserine1833 relationship: transforms_into CCO:B0013316 ! NUMA1_HUMAN-Phosphoserine1834 relationship: transforms_into CCO:B0013317 ! NUMA1_HUMAN-Phosphoserine1840 relationship: transforms_into CCO:B0013318 ! NUMA1_HUMAN-Phosphoserine1847 relationship: transforms_into CCO:B0013319 ! NUMA1_HUMAN-Phosphoserine1853 relationship: transforms_into CCO:B0013320 ! NUMA1_HUMAN-Phosphoserine1862 relationship: transforms_into CCO:B0013321 ! NUMA1_HUMAN-Phosphoserine1872 relationship: transforms_into CCO:B0013322 ! NUMA1_HUMAN-Phosphoserine1945 relationship: transforms_into CCO:B0013323 ! NUMA1_HUMAN-Phosphothreonine2000 relationship: transforms_into CCO:B0013324 ! NUMA1_HUMAN-Phosphothreonine2055 relationship: transforms_into CCO:B0013325 ! NUMA1_HUMAN-Phosphoserine2077 relationship: transforms_into CCO:B0013326 ! NUMA1_HUMAN-Phosphothreonine2106 [Term] id: CCO:B0001796 name: HECAM_HUMAN def: "Hepatocyte cell adhesion molecule precursor" [UniProtKB:Q14CZ8] synonym: "Protein hepaCAM" EXACT [UniProtKB:Q14CZ8] xref: EMBL:AAI04832.1 xref: EMBL:AAI13563.1 xref: EMBL:AAQ93018.1 xref: EMBL:BAC05297.1 xref: EMBL:BAC85486.1 xref: EMBL:CAD39081.1 xref: UniProtKB:Q14CZ8 xref: UniProtKB:Q67IP8 xref: UniProtKB:Q6ZWL4 xref: UniProtKB:Q8N7I3 xref: UniProtKB:Q8ND35 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004796 ! HEPACAM_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0012177 ! HECAM_HUMAN-Phosphoserine278 relationship: transforms_into CCO:B0012178 ! HECAM_HUMAN-Phosphoserine318 relationship: transforms_into CCO:B0012179 ! HECAM_HUMAN-Phosphoserine350 [Term] id: CCO:B0001797 name: CND2_HUMAN def: "Condensin complex subunit 2" [UniProtKB:Q15003] synonym: "Barren homolog protein 1" EXACT [UniProtKB:Q15003] synonym: "Chromosome-associated protein H" EXACT [UniProtKB:Q15003] synonym: "hCAP-H" EXACT [UniProtKB:Q15003] synonym: "Non-SMC condensin I complex subunit H" EXACT [UniProtKB:Q15003] synonym: "XCAP-H homolog" EXACT [UniProtKB:Q15003] xref: EMBL:AAH24211.1 xref: EMBL:BAA07556.1 xref: UniProtKB:Q15003 xref: UniProtKB:Q8TB87 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004377 ! NCAPH_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000038 ! mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: transforms_into CCO:B0011296 ! CND2_HUMAN-Phosphothreonine49 relationship: transforms_into CCO:B0011297 ! CND2_HUMAN-Phosphoserine78 relationship: transforms_into CCO:B0011298 ! CND2_HUMAN-Phosphoserine81 relationship: transforms_into CCO:B0011299 ! CND2_HUMAN-Phosphoserine92 relationship: transforms_into CCO:B0011300 ! CND2_HUMAN-Phosphoserine96 relationship: transforms_into CCO:B0011301 ! CND2_HUMAN-Phosphoserine201 relationship: transforms_into CCO:B0011302 ! CND2_HUMAN-Phosphoserine335 relationship: transforms_into CCO:B0011303 ! CND2_HUMAN-Phosphothreonine605 [Term] id: CCO:B0001798 name: FL2D_HUMAN def: "Pre-mRNA-splicing regulator WTAP" [UniProtKB:Q15007] synonym: "Female-lethal(2)D homolog" EXACT [UniProtKB:Q15007] synonym: "hFL(2)D" EXACT [UniProtKB:Q15007] synonym: "Wilms tumor 1-associating protein" EXACT [UniProtKB:Q15007] synonym: "WT1-associated protein" EXACT [UniProtKB:Q15007] xref: EMBL:AAH00383.1 xref: EMBL:AAH04432.1 xref: EMBL:AAH69192.1 xref: EMBL:AAK54764.1 xref: EMBL:BAA03495.1 xref: EMBL:CAC10188.1 xref: EMBL:CAC29495.1 xref: EMBL:CAI21849.1 xref: EMBL:EAW47622.1 xref: UniProtKB:Q15007 xref: UniProtKB:Q5TCL8 xref: UniProtKB:Q96T28 xref: UniProtKB:Q9BYJ7 xref: UniProtKB:Q9H4E2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004649 ! WTAP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005921 ! magea11-wtap physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011883 ! FL2D_HUMAN-Phosphoserine244 relationship: transforms_into CCO:B0011884 ! FL2D_HUMAN-Phosphoserine306 [Term] id: CCO:B0001799 name: MD2BP_HUMAN def: "MAD2L1-binding protein" [UniProtKB:Q15013] synonym: "Caught by MAD2 protein" EXACT [UniProtKB:Q15013] xref: EMBL:AAH02904.1 xref: EMBL:BAA03552.1 xref: EMBL:CAC19507.1 xref: UniProtKB:Q15013 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005047 ! MAD2L1BP_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0005937 ! krt15-mad2l1bp physical interaction relationship: participates_in CCO:I0008021 ! mad2l1bp-tp53 physical interaction relationship: participates_in CCO:I0008130 ! mad2l1bp-eef1a1 physical interaction relationship: participates_in CCO:I0008131 ! mad2l1bp-htatip physical interaction relationship: participates_in CCO:I0008132 ! mad2l1bp-ptn physical interaction relationship: participates_in CCO:I0008133 ! mad2l1bp-setdb1 physical interaction relationship: participates_in CCO:I0008260 ! mad2l1bp-kiaa1377 physical interaction relationship: participates_in CCO:I0008261 ! mad2l1bp-igsf21 physical interaction relationship: participates_in CCO:I0008262 ! mad2l1bp-rif1 physical interaction relationship: participates_in CCO:I0008405 ! mad2l1bp-trip13-1 physical interaction relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis relationship: transforms_into CCO:B0012846 ! MD2BP_HUMAN-Phosphoserine29 relationship: transforms_into CCO:B0012847 ! MD2BP_HUMAN-Phosphothreonine39 [Term] id: CCO:B0001800 name: SEPT2_HUMAN def: "Septin-2" [UniProtKB:Q15019] synonym: "Protein NEDD5" EXACT [UniProtKB:Q15019] xref: EMBL:AAB92377.1 xref: EMBL:AAH14455.1 xref: EMBL:AAH33559.1 xref: EMBL:BAA05893.1 xref: EMBL:BAA09928.2 xref: UniProtKB:Q14132 xref: UniProtKB:Q15019 xref: UniProtKB:Q8IUK9 xref: UniProtKB:Q96CB0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005585 ! SEPT2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005732 ! dazap2-sept2 physical interaction relationship: participates_in CCO:I0005825 ! sept2-sept6 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013991 ! SEPT2_HUMAN-Phosphotyrosine17 relationship: transforms_into CCO:B0013992 ! SEPT2_HUMAN-Phosphoserine218 relationship: transforms_into CCO:B0013993 ! SEPT2_HUMAN-Phosphothreonine228 [Term] id: CCO:B0001801 name: CND1_HUMAN def: "Condensin complex subunit 1" [UniProtKB:Q15021] synonym: "Chromosome condensation-related SMC-associated protein 1" EXACT [UniProtKB:Q15021] synonym: "Chromosome-associated protein D2" EXACT [UniProtKB:Q15021] synonym: "hCAP-D2" EXACT [UniProtKB:Q15021] synonym: "Non-SMC condensin I complex subunit D2" EXACT [UniProtKB:Q15021] synonym: "XCAP-D2 homolog" EXACT [UniProtKB:Q15021] xref: EMBL:AAH28182.1 xref: EMBL:BAA09930.2 xref: UniProtKB:Q15021 xref: UniProtKB:Q8N6U3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004376 ! NCAPD2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: transforms_into CCO:B0011280 ! CND1_HUMAN-Phosphothreonine103 relationship: transforms_into CCO:B0011281 ! CND1_HUMAN-Phosphothreonine577 relationship: transforms_into CCO:B0011282 ! CND1_HUMAN-Phosphoserine585 relationship: transforms_into CCO:B0011283 ! CND1_HUMAN-Phosphoserine1310 relationship: transforms_into CCO:B0011284 ! CND1_HUMAN-Phosphoserine1330 relationship: transforms_into CCO:B0011285 ! CND1_HUMAN-Phosphothreonine1331 relationship: transforms_into CCO:B0011286 ! CND1_HUMAN-Phosphoserine1333 relationship: transforms_into CCO:B0011287 ! CND1_HUMAN-Phosphothreonine1339 relationship: transforms_into CCO:B0011288 ! CND1_HUMAN-Phosphoserine1366 relationship: transforms_into CCO:B0011289 ! CND1_HUMAN-Phosphoserine1367 relationship: transforms_into CCO:B0011290 ! CND1_HUMAN-Phosphoserine1370 relationship: transforms_into CCO:B0011291 ! CND1_HUMAN-Phosphoserine1371 relationship: transforms_into CCO:B0011292 ! CND1_HUMAN-Phosphoserine1376 relationship: transforms_into CCO:B0011293 ! CND1_HUMAN-Phosphothreonine1384 relationship: transforms_into CCO:B0011294 ! CND1_HUMAN-Phosphothreonine1388 relationship: transforms_into CCO:B0011295 ! CND1_HUMAN-Phosphothreonine1389 [Term] id: CCO:B0001802 name: CD5R1_HUMAN def: "Cyclin-dependent kinase 5 activator 1 precursor" [UniProtKB:Q15078] synonym: "CDK5 activator 1" EXACT [UniProtKB:Q15078] synonym: "Cyclin-dependent kinase 5 regulatory subunit 1" EXACT [UniProtKB:Q15078] synonym: "p23" EXACT [UniProtKB:Q15078] synonym: "p25" EXACT [UniProtKB:Q15078] synonym: "p35" EXACT [UniProtKB:Q15078] synonym: "Tau protein kinase II 23 kDa subunit" EXACT [UniProtKB:Q15078] synonym: "TPKII regulatory subunit" EXACT [UniProtKB:Q15078] xref: EMBL:AAH20580.1 xref: EMBL:AAQ74776.1 xref: EMBL:CAA56587.1 xref: UniProtKB:Q15078 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004280 ! CDK5R1_human relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003202 ! cyclin-dependent protein kinase 5 activator activity relationship: has_function CCO:F0005870 ! protein serine/threonine kinase activator activity relationship: has_function CCO:F0006104 ! cadherin binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000803 ! cyclin-dependent protein kinase 5 activator complex relationship: located_in CCO:C0001004 ! axon relationship: located_in CCO:C0001005 ! dendrite relationship: located_in CCO:C0001006 ! growth cone relationship: located_in CCO:C0001300 ! neuromuscular junction relationship: located_in CCO:C0001709 ! cell soma relationship: located_in CCO:C0001729 ! dendritic spine relationship: located_in CCO:C0001766 ! contractile fiber relationship: participates_in CCO:I0005786 ! cdk5r1-tsc22d4 physical interaction relationship: participates_in CCO:I0007828 ! cdk5-cdk5r1-1 direct interaction relationship: participates_in CCO:I0007829 ! cdk5-cdk5r1-2 direct interaction relationship: participates_in CCO:I0007830 ! cdk5-cdk5r1-3 direct interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity [Term] id: CCO:B0001803 name: CDK10_HUMAN def: "Cell division protein kinase 10" [UniProtKB:Q15131] synonym: "EC 2.7.11.22" EXACT [UniProtKB:Q15131] synonym: "Serine/threonine-protein kinase PISSLRE" EXACT [UniProtKB:Q15131] xref: EMBL:AAA60092.2 xref: EMBL:AAH17342.1 xref: EMBL:AAH25301.1 xref: EMBL:CAA55137.1 xref: EMBL:CAB37619.1 xref: EMBL:CAL37781.1 xref: EMBL:CAL38055.1 xref: EMBL:CAL38082.1 xref: UniProtKB:Q0VGZ7 xref: UniProtKB:Q15130 xref: UniProtKB:Q15131 xref: UniProtKB:Q6PJC0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004298 ! CDK10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000100 ! traversing start control point of mitotic cell cycle relationship: transforms_into CCO:B0011102 ! CDK10_HUMAN-Phosphothreonine196 [Term] id: CCO:B0001806 name: DHC24_HUMAN def: "24-dehydrocholesterol reductase precursor" [UniProtKB:Q15392] synonym: "3-beta-hydroxysterol delta-24-reductase" EXACT [UniProtKB:Q15392] synonym: "Diminuto/dwarf1 homolog" EXACT [UniProtKB:Q15392] synonym: "EC 1.3.1.-" EXACT [UniProtKB:Q15392] synonym: "Seladin-1" EXACT [UniProtKB:Q15392] xref: EMBL:AAG17288.1 xref: EMBL:AAH04375.1 xref: EMBL:AAH11669.1 xref: EMBL:AAL15644.1 xref: EMBL:BAA02806.3 xref: UniProtKB:Q15392 xref: UniProtKB:Q9HBA8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004466 ! DHCR24_human relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0003172 ! oxidoreductase activity relationship: has_function CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor relationship: has_function CCO:F0004208 ! enzyme binding relationship: has_function CCO:F0005688 ! peptide antigen binding relationship: has_function CCO:F0007948 ! delta24-sterol reductase activity relationship: has_function CCO:F0007986 ! FAD binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000021 ! Golgi membrane relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000364 ! endoplasmic reticulum relationship: located_in CCO:C0000370 ! endoplasmic reticulum membrane relationship: located_in CCO:C0000375 ! Golgi apparatus relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0011501 ! DHC24_HUMAN-Phosphothreonine110 [Term] id: CCO:B0001807 name: DLG7_HUMAN def: "Disks large-associated protein DLG7" [UniProtKB:Q15398] synonym: "Discs large homolog 7" EXACT [UniProtKB:Q15398] synonym: "Hepatoma up-regulated protein" EXACT [UniProtKB:Q15398] synonym: "HURP" EXACT [UniProtKB:Q15398] xref: EMBL:AAH10658.2 xref: EMBL:AAH16276.2 xref: EMBL:AAP36008.1 xref: EMBL:BAA02797.2 xref: EMBL:BAB97376.1 xref: UniProtKB:Q15398 xref: UniProtKB:Q8NG58 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004480 ! DLG7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005828 ! dlg7-traf2 physical interaction relationship: participates_in CCO:I0005829 ! dlg7-trim37 physical interaction relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000093 ! mitotic chromosome movement towards spindle pole relationship: participates_in CCO:P0000253 ! positive regulation of mitotic metaphase/anaphase transition relationship: transforms_into CCO:B0011528 ! DLG7_HUMAN-Phosphoserine67 relationship: transforms_into CCO:B0011529 ! DLG7_HUMAN-Phosphothreonine219 relationship: transforms_into CCO:B0011530 ! DLG7_HUMAN-Phosphothreonine224 relationship: transforms_into CCO:B0011531 ! DLG7_HUMAN-Phosphothreonine329 relationship: transforms_into CCO:B0011532 ! DLG7_HUMAN-Phosphothreonine401 relationship: transforms_into CCO:B0011533 ! DLG7_HUMAN-Phosphothreonine402 relationship: transforms_into CCO:B0011534 ! DLG7_HUMAN-Phosphoserine618 relationship: transforms_into CCO:B0011535 ! DLG7_HUMAN-Phosphothreonine639 relationship: transforms_into CCO:B0011536 ! DLG7_HUMAN-Phosphoserine642 relationship: transforms_into CCO:B0011537 ! DLG7_HUMAN-Phosphoserine662 relationship: transforms_into CCO:B0011538 ! DLG7_HUMAN-Phosphoserine689 relationship: transforms_into CCO:B0011539 ! DLG7_HUMAN-Phosphothreonine759 relationship: transforms_into CCO:B0011540 ! DLG7_HUMAN-Phosphoserine774 relationship: transforms_into CCO:B0011541 ! DLG7_HUMAN-Phosphoserine777 relationship: transforms_into CCO:B0011542 ! DLG7_HUMAN-Phosphoserine839 [Term] id: CCO:B0001808 name: SYCP1_HUMAN def: "Synaptonemal complex protein 1" [UniProtKB:Q15431] synonym: "Cancer/testis antigen 8" EXACT [UniProtKB:Q15431] synonym: "CT8" EXACT [UniProtKB:Q15431] synonym: "SCP-1" EXACT [UniProtKB:Q15431] xref: EMBL:BAA22586.1 xref: EMBL:CAA64956.1 xref: UniProtKB:O14963 xref: UniProtKB:Q15431 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005710 ! SYCP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000121 ! synaptonemal complex assembly relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001810 name: TERF2_HUMAN def: "Telomeric repeat-binding factor 2" [UniProtKB:Q15554] synonym: "Telomeric DNA-binding protein" EXACT [UniProtKB:Q15554] synonym: "TTAGGG repeat-binding factor 2" EXACT [UniProtKB:Q15554] xref: EMBL:AAB81135.1 xref: EMBL:AAD00821.1 xref: EMBL:AAH24890.1 xref: EMBL:CAA63769.1 xref: UniProtKB:Q15554 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005761 ! TERF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006212 ! wrn-terf2-3 colocalization relationship: participates_in CCO:I0006327 ! pot1-terf2 physical interaction relationship: participates_in CCO:I0006328 ! acd-terf2 physical interaction relationship: participates_in CCO:I0006329 ! rap1-terf2-2 physical interaction relationship: participates_in CCO:I0006330 ! terf2-tinf2 physical interaction relationship: participates_in CCO:I0006331 ! rap1-terf2-3 physical interaction relationship: participates_in CCO:I0006534 ! wrn-terf2-1 physical interaction relationship: participates_in CCO:I0006538 ! blm-terf2-4 colocalization relationship: participates_in CCO:I0006875 ! wrn-terf2-4 direct interaction relationship: participates_in CCO:I0006876 ! wrn-terf2-5 direct interaction relationship: participates_in CCO:I0006877 ! wrn-terf2-6 direct interaction relationship: participates_in CCO:I0006878 ! wrn-terf2-7 direct interaction relationship: participates_in CCO:I0006881 ! blm-terf2-9 direct interaction relationship: participates_in CCO:I0006882 ! blm-terf2-10 direct interaction relationship: participates_in CCO:I0006981 ! wrn-terf2-2 physical interaction relationship: participates_in CCO:I0007131 ! terf2ip-rad50 physical interaction relationship: participates_in CCO:I0007283 ! blm-terf2-1 physical interaction relationship: participates_in CCO:I0007358 ! blm-terf2-2 physical interaction relationship: participates_in CCO:I0007359 ! blm-terf2-5 colocalization relationship: participates_in CCO:I0007573 ! wrn-terf2-8 direct interaction relationship: participates_in CCO:I0007574 ! blm-terf2-3 direct interaction relationship: participates_in CCO:I0007768 ! blm-terf2-6 direct interaction relationship: participates_in CCO:I0007893 ! pot1-terf2-1 physical interaction relationship: participates_in CCO:I0007894 ! tinf2-terf1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014334 ! TERF2_HUMAN-Phosphoserine323 relationship: transforms_into CCO:B0014335 ! TERF2_HUMAN-Phosphoserine368 relationship: transforms_into CCO:B0014336 ! TERF2_HUMAN-Phosphoserine380 [Term] id: CCO:B0001811 name: MARE2_HUMAN def: "Microtubule-associated protein RP/EB family member 2" [UniProtKB:Q15555] synonym: "APC-binding protein EB2" EXACT [UniProtKB:Q15555] synonym: "EB2" EXACT [UniProtKB:Q15555] synonym: "End-binding protein 2" EXACT [UniProtKB:Q15555] xref: EMBL:AAH07318.1 xref: EMBL:AAV38889.1 xref: EMBL:BAA83375.1 xref: EMBL:CAA63923.1 xref: EMBL:CAG38782.1 xref: UniProtKB:Q15555 xref: UniProtKB:Q9UQ33 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005025 ! MAPRE2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005722 ! lmo2-mapre2 physical interaction relationship: participates_in CCO:I0005846 ! mapre2-nif3l1 physical interaction relationship: participates_in CCO:I0005859 ! mapre2-mapre2 physical interaction relationship: participates_in CCO:I0005892 ! mapre2-mapre3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012767 ! MARE2_HUMAN-Phosphotyrosine167 relationship: transforms_into CCO:B0012768 ! MARE2_HUMAN-Phosphoserine200 relationship: transforms_into CCO:B0012769 ! MARE2_HUMAN-Phosphoserine219 relationship: transforms_into CCO:B0012770 ! MARE2_HUMAN-Phosphoserine223 [Term] id: CCO:B0001812 name: MARE1_HUMAN def: "Microtubule-associated protein RP/EB family member 1" [UniProtKB:Q15691] synonym: "APC-binding protein EB1" EXACT [UniProtKB:Q15691] synonym: "EB1" EXACT [UniProtKB:Q15691] synonym: "End-binding protein 1" EXACT [UniProtKB:Q15691] xref: EMBL:AAC09471.1 xref: EMBL:AAI06069.1 xref: EMBL:AAI09282.1 xref: EMBL:CAB53072.1 xref: UniProtKB:Q15691 xref: UniProtKB:Q3KQS8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005024 ! MAPRE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005963 ! pin2_trf1-eb1-1 physical interaction relationship: participates_in CCO:I0007457 ! eb1-apc-1 physical interaction relationship: participates_in CCO:I0007458 ! eb1-pin2_trf1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012763 ! MARE1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0012764 ! MARE1_HUMAN-Phosphotyrosine124 relationship: transforms_into CCO:B0012765 ! MARE1_HUMAN-Phosphoserine155 relationship: transforms_into CCO:B0012766 ! MARE1_HUMAN-Phosphothreonine166 [Term] id: CCO:B0001813 name: UB2V2_HUMAN def: "Ubiquitin-conjugating enzyme E2 variant 2" [UniProtKB:Q15819] synonym: "DDVit 1" EXACT [UniProtKB:Q15819] synonym: "EDPF-1" EXACT [UniProtKB:Q15819] synonym: "Enterocyte differentiation-associated factor EDAF-1" EXACT [UniProtKB:Q15819] synonym: "Enterocyte differentiation-promoting factor" EXACT [UniProtKB:Q15819] synonym: "MMS2" EXACT [UniProtKB:Q15819] synonym: "Vitamin D3-inducible protein" EXACT [UniProtKB:Q15819] xref: EMBL:AAB04758.2 xref: EMBL:AAC05381.1 xref: EMBL:AAH07051.1 xref: EMBL:AAH16332.1 xref: EMBL:AAH16710.1 xref: EMBL:AAH28673.1 xref: EMBL:AAH62418.1 xref: EMBL:AAP35390.1 xref: EMBL:CAA66717.1 xref: EMBL:CAG28556.1 xref: UniProtKB:Q15819 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005855 ! UBE2V2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008349 ! ube2v2-rif1 physical interaction relationship: participates_in CCO:I0008510 ! suv39h2-ube2v2 physical interaction [Term] id: CCO:B0001814 name: STK11_HUMAN def: "Serine/threonine-protein kinase 11" [UniProtKB:Q15831] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q15831] synonym: "Renal carcinoma antigen NY-REN-19" EXACT [UniProtKB:Q15831] synonym: "Serine/threonine-protein kinase LKB1" EXACT [UniProtKB:Q15831] xref: EMBL:AAB05809.1 xref: EMBL:AAB97833.1 xref: EMBL:AAC15742.1 xref: EMBL:AAC39527.1 xref: EMBL:AAH07981.1 xref: EMBL:AAH19334.1 xref: UniProtKB:Q15831 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005691 ! STK11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006454 ! lkb1-strad-2 physical interaction relationship: participates_in CCO:I0006455 ! lkb1-strad-4 physical interaction relationship: participates_in CCO:I0006456 ! stk11-strad-5 physical interaction relationship: participates_in CCO:I0006778 ! lkb1-strad-7 phosphorylation relationship: participates_in CCO:I0006779 ! lkb1-strad-8 phosphorylation relationship: participates_in CCO:I0006927 ! stk11-strad-6 colocalization relationship: participates_in CCO:I0007201 ! stk11-mo25-1 physical interaction relationship: participates_in CCO:I0007208 ! als2cr2-stk11-1 physical interaction relationship: participates_in CCO:I0007217 ! stk11-mark4-1 physical interaction relationship: participates_in CCO:I0007222 ! mo25-stk11-1 physical interaction relationship: participates_in CCO:I0007223 ! stk11-als2cr2-1 physical interaction relationship: participates_in CCO:I0007474 ! lkb1-strad-1 physical interaction relationship: participates_in CCO:I0008491 ! prei3-stk11 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0014250 ! STK11_HUMAN-Phosphoserine31 relationship: transforms_into CCO:B0014251 ! STK11_HUMAN-Phosphothreonine336 relationship: transforms_into CCO:B0014252 ! STK11_HUMAN-Phosphothreonine363 relationship: transforms_into CCO:B0014253 ! STK11_HUMAN-Phosphoserine428 [Term] id: CCO:B0001815 name: Q16164_HUMAN def: "G1 phase-specific gene protein" [UniProtKB:Q16164] xref: EMBL:AAB30172.1 xref: UniProtKB:Q16164 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005990 ! G1 phase-specific gene_human relationship: has_function CCO:F0000272 ! molecular_function relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle [Term] id: CCO:B0001816 name: SEPT7_HUMAN def: "Septin-7" [UniProtKB:Q16181] synonym: "CDC10 protein homolog" EXACT [UniProtKB:Q16181] xref: EMBL:AAB31337.1 xref: EMBL:AAH67264.2 xref: EMBL:AAH93640.2 xref: EMBL:AAH93642.2 xref: UniProtKB:Q16181 xref: UniProtKB:Q52M76 xref: UniProtKB:Q6NX50 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005590 ! SEPT7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014003 ! SEPT7_HUMAN-Phosphothreonine228 relationship: transforms_into CCO:B0014004 ! SEPT7_HUMAN-Phosphotyrosine319 relationship: transforms_into CCO:B0014005 ! SEPT7_HUMAN-Phosphoserine334 relationship: transforms_into CCO:B0014006 ! SEPT7_HUMAN-Phosphoserine423 relationship: transforms_into CCO:B0014007 ! SEPT7_HUMAN-Phosphothreonine426 relationship: transforms_into CCO:B0031373 ! SEPT7_HUMAN-Phosphotyrosine30 [Term] id: CCO:B0001817 name: E2F4_HUMAN def: "Transcription factor E2F4" [UniProtKB:Q16254] synonym: "E2F-4" EXACT [UniProtKB:Q16254] xref: EMBL:AAB32597.1 xref: EMBL:AAC50119.1 xref: EMBL:AAF65226.1 xref: EMBL:AAH33180.1 xref: EMBL:AAM77918.1 xref: EMBL:CAA60050.2 xref: EMBL:EAW83094.1 xref: UniProtKB:A6NGR8 xref: UniProtKB:Q12991 xref: UniProtKB:Q15328 xref: UniProtKB:Q16254 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004536 ! E2F4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006018 ! e2f4-trrap-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001818 name: EXT1_HUMAN def: "Exostosin-1" [UniProtKB:Q16394] synonym: "EC 2.4.1.224" EXACT [UniProtKB:Q16394] synonym: "EC 2.4.1.225" EXACT [UniProtKB:Q16394] synonym: "Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase" EXACT [UniProtKB:Q16394] synonym: "Multiple exostoses protein 1" EXACT [UniProtKB:Q16394] synonym: "Putative tumor suppressor protein EXT1" EXACT [UniProtKB:Q16394] xref: EMBL:AAB62283.1 xref: EMBL:AAC51154.1 xref: EMBL:AAH01174.1 xref: UniProtKB:Q16394 xref: UniProtKB:Q9BVI9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004602 ! EXT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001819 name: CDC37_HUMAN def: "Hsp90 co-chaperone Cdc37" [UniProtKB:Q16543] synonym: "Hsp90 chaperone protein kinase-targeting subunit" EXACT [UniProtKB:Q16543] synonym: "p50Cdc37" EXACT [UniProtKB:Q16543] xref: EMBL:AAB04798.1 xref: EMBL:AAB63979.1 xref: EMBL:AAH00083.1 xref: EMBL:AAH08793.1 xref: EMBL:AAW34362.1 xref: UniProtKB:Q16543 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004289 ! CDC37_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005999 ! cdc37-cdk4 physical interaction relationship: participates_in CCO:I0006396 ! aah62584-cdc37 physical interaction relationship: participates_in CCO:I0006427 ! map3k14-cdc37 physical interaction relationship: participates_in CCO:I0006430 ! chuk-cdc37 physical interaction relationship: participates_in CCO:I0006431 ! ikbkb-cdc37 physical interaction relationship: participates_in CCO:I0006432 ! ikbke-cdc37 physical interaction relationship: participates_in CCO:I0006433 ! ikbkg-cdc37 physical interaction relationship: participates_in CCO:I0006434 ! map3k1-cdc37 physical interaction relationship: participates_in CCO:I0006436 ! map3k3-cdc37 physical interaction relationship: participates_in CCO:I0006439 ! tbk1-cdc37 physical interaction relationship: participates_in CCO:I0006608 ! cdk6-cdc37-1 physical interaction relationship: participates_in CCO:I0006609 ! cdk4-cdc37-1 physical interaction relationship: participates_in CCO:I0006872 ! eif2ak1-cdc37-8 physical interaction relationship: participates_in CCO:I0007179 ! prkaa1-aakg1-1 physical interaction relationship: participates_in CCO:I0007182 ! nuak2-cdc37-1 physical interaction relationship: participates_in CCO:I0007392 ! cdk4-cdc37 physical interaction relationship: participates_in CCO:I0007393 ! cdk6-cdc37 physical interaction relationship: participates_in CCO:I0007396 ! cdc37-hsp90 physical interaction relationship: participates_in CCO:I0007397 ! cdc37-akt1 physical interaction relationship: participates_in CCO:I0007398 ! cdc37-akt2 physical interaction relationship: participates_in CCO:I0007399 ! cdc37-akt3 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: transforms_into CCO:B0011082 ! CDC37_HUMAN-Phosphotyrosine298 [Term] id: CCO:B0001820 name: M3K11_HUMAN def: "Mitogen-activated protein kinase kinase kinase 11" [UniProtKB:Q16584] synonym: "EC 2.7.11.25" EXACT [UniProtKB:Q16584] synonym: "Mixed lineage kinase 3" EXACT [UniProtKB:Q16584] synonym: "Src-homology 3 domain-containing proline-rich kinase" EXACT [UniProtKB:Q16584] xref: EMBL:AAA19647.1 xref: EMBL:AAA59859.1 xref: EMBL:AAH11263.1 xref: EMBL:AAH64543.1 xref: EMBL:BAD92892.1 xref: EMBL:BAD96501.1 xref: UniProtKB:Q16584 xref: UniProtKB:Q53H00 xref: UniProtKB:Q59F06 xref: UniProtKB:Q6P2G4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005004 ! MAP3K11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006963 ! map4k2-mlk3-1 physical interaction relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle relationship: transforms_into CCO:B0012715 ! M3K11_HUMAN-Phosphothreonine277 relationship: transforms_into CCO:B0012716 ! M3K11_HUMAN-Phosphoserine281 relationship: transforms_into CCO:B0012717 ! M3K11_HUMAN-Phosphoserine507 relationship: transforms_into CCO:B0012718 ! M3K11_HUMAN-Phosphoserine524 relationship: transforms_into CCO:B0012719 ! M3K11_HUMAN-Phosphoserine555 relationship: transforms_into CCO:B0012720 ! M3K11_HUMAN-Phosphoserine556 relationship: transforms_into CCO:B0012721 ! M3K11_HUMAN-Phosphoserine654 relationship: transforms_into CCO:B0012722 ! M3K11_HUMAN-Phosphoserine705 relationship: transforms_into CCO:B0012723 ! M3K11_HUMAN-Phosphoserine724 relationship: transforms_into CCO:B0012724 ! M3K11_HUMAN-Phosphoserine727 relationship: transforms_into CCO:B0012725 ! M3K11_HUMAN-Phosphothreonine738 relationship: transforms_into CCO:B0012726 ! M3K11_HUMAN-Phosphoserine740 relationship: transforms_into CCO:B0012727 ! M3K11_HUMAN-Phosphoserine746 relationship: transforms_into CCO:B0012728 ! M3K11_HUMAN-Phosphoserine758 relationship: transforms_into CCO:B0012729 ! M3K11_HUMAN-Phosphoserine770 relationship: transforms_into CCO:B0012730 ! M3K11_HUMAN-Phosphoserine793 [Term] id: CCO:B0001821 name: CCNG2_HUMAN def: "Cyclin-G2" [UniProtKB:Q16589] xref: EMBL:AAC41978.1 xref: EMBL:AAC50689.1 xref: EMBL:AAN40704.1 xref: EMBL:AAV38310.1 xref: UniProtKB:Q16589 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004255 ! CCNG2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0035990 ! CCNG2_HUMAN-Phosphoserine220 relationship: transforms_into CCO:B0035991 ! CCNG2_HUMAN-Phosphoserine234 [Term] id: CCO:B0001822 name: MK06_HUMAN def: "Mitogen-activated protein kinase 6" [UniProtKB:Q16659] synonym: "EC 2.7.11.24" EXACT [UniProtKB:Q16659] synonym: "ERK-3" EXACT [UniProtKB:Q16659] synonym: "Extracellular signal-regulated kinase 3" EXACT [UniProtKB:Q16659] synonym: "MAP kinase isoform p97" EXACT [UniProtKB:Q16659] synonym: "p97-MAPK" EXACT [UniProtKB:Q16659] xref: EMBL:AAA98769.1 xref: EMBL:AAH35492.1 xref: EMBL:AAL17605.1 xref: EMBL:CAA56709.1 xref: EMBL:CAH18246.1 xref: UniProtKB:Q16659 xref: UniProtKB:Q68DH4 xref: UniProtKB:Q8IYN8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005092 ! MAPK6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012944 ! MK06_HUMAN-Phosphothreonine626 relationship: transforms_into CCO:B0012945 ! MK06_HUMAN-Phosphotyrosine628 [Term] id: CCO:B0001823 name: CDKN3_HUMAN def: "Cyclin-dependent kinase inhibitor 3" [UniProtKB:Q16667] synonym: "CDK2-associated dual-specificity phosphatase" EXACT [UniProtKB:Q16667] synonym: "Cyclin-dependent kinase interactor 1" EXACT [UniProtKB:Q16667] synonym: "Cyclin-dependent kinase-interacting protein 2" EXACT [UniProtKB:Q16667] synonym: "EC 3.1.3.16" EXACT [UniProtKB:Q16667] synonym: "EC 3.1.3.48" EXACT [UniProtKB:Q16667] synonym: "Kinase-associated phosphatase" EXACT [UniProtKB:Q16667] xref: EMBL:AAA60222.1 xref: EMBL:AAA66496.1 xref: EMBL:AAC04932.1 xref: EMBL:AAK06365.1 xref: EMBL:AAK06368.1 xref: EMBL:AAK06370.1 xref: EMBL:AAK06371.1 xref: EMBL:AAK06373.1 xref: EMBL:AAK06374.1 xref: EMBL:AAK06377.1 xref: EMBL:AAK06378.1 xref: EMBL:AAK06384.1 xref: EMBL:AAN86348.1 xref: UniProtKB:Q16667 xref: UniProtKB:Q99585 xref: UniProtKB:Q9BPW7 xref: UniProtKB:Q9BY36 xref: UniProtKB:Q9C042 xref: UniProtKB:Q9C047 xref: UniProtKB:Q9C049 xref: UniProtKB:Q9C051 xref: UniProtKB:Q9C053 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004308 ! CDKN3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006566 ! cdk2-cdkn3-1 direct interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001825 name: TPD53_HUMAN def: "Tumor protein D53" [UniProtKB:Q16890] synonym: "hD53" EXACT [UniProtKB:Q16890] synonym: "Tumor protein D52-like 1" EXACT [UniProtKB:Q16890] xref: EMBL:AAB40894.1 xref: EMBL:AAB40895.1 xref: UniProtKB:Q16890 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005817 ! TPD52L1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0005713 ! identical protein binding relationship: has_function CCO:F0005714 ! protein homodimerization activity relationship: has_function CCO:F0006299 ! protein heterodimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0001996 ! perinuclear region of cytoplasm relationship: participates_in CCO:I0006044 ! hd52-hd53-1 physical interaction relationship: participates_in CCO:I0006045 ! hd53-hd52-1 physical interaction relationship: participates_in CCO:I0006046 ! hd53-hd53-1 physical interaction relationship: participates_in CCO:I0006739 ! hd53-hd53-2 physical interaction relationship: participates_in CCO:I0006740 ! hd53-hd53-3 physical interaction relationship: participates_in CCO:I0006741 ! hd53-hd53-4 physical interaction relationship: participates_in CCO:I0007413 ! nyd_sp25-tpd53 physical interaction relationship: participates_in CCO:I0007586 ! hd52-hd53-2 physical interaction relationship: participates_in CCO:I0008344 ! tpd52l1-c7orf36 physical interaction relationship: participates_in CCO:I0008345 ! tpd52l1-eif3s1 physical interaction relationship: participates_in CCO:I0008443 ! tpd52l1-gpr135 physical interaction relationship: participates_in CCO:I0008444 ! tpd52l1-hdac1 physical interaction relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle [Term] id: CCO:B0001827 name: Q1WWK5_HUMAN def: "SEPT9 protein" [UniProtKB:Q1WWK5] xref: EMBL:AAI14551.1 xref: UniProtKB:Q1WWK5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005592 ! SEPT9_human relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001829 name: PDS5A_HUMAN def: "Sister chromatid cohesion protein PDS5 homolog A" [UniProtKB:Q29RF7] synonym: "Cell proliferation-inducing gene 54 protein" EXACT [UniProtKB:Q29RF7] synonym: "SCC-112" EXACT [UniProtKB:Q29RF7] synonym: "Sister chromatid cohesion protein 112" EXACT [UniProtKB:Q29RF7] xref: EMBL:AAH41361.1 xref: EMBL:AAI14219.1 xref: EMBL:AAI26226.1 xref: EMBL:AAM82347.1 xref: EMBL:AAT52214.1 xref: EMBL:BAA31623.1 xref: EMBL:BAC05286.1 xref: EMBL:CAH18263.1 xref: UniProtKB:Q29RF7 xref: UniProtKB:Q2TTR5 xref: UniProtKB:Q68DF7 xref: UniProtKB:Q8N7J4 xref: UniProtKB:Q8NG14 xref: UniProtKB:Q9Y4D4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005295 ! PDS5A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007039 ! wapl-cspg6-1 physical interaction relationship: participates_in CCO:I0007711 ! wapl-cspg6-4 physical interaction relationship: participates_in CCO:I0007712 ! wapl-cspg6-5 physical interaction relationship: participates_in CCO:I0007713 ! wapl-cspg6-6 physical interaction relationship: participates_in CCO:I0007714 ! wapl-cspg6-7 physical interaction relationship: participates_in CCO:I0007715 ! wapl-cspg6-9 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013485 ! PDS5A_HUMAN-Phosphothreonine1208 relationship: transforms_into CCO:B0013486 ! PDS5A_HUMAN-Phosphoserine1305 [Term] id: CCO:B0001831 name: Q3LRW5_HUMAN def: "Cellular tumor antigen p53" [UniProtKB:Q3LRW5] xref: EMBL:ABA29753.1 xref: UniProtKB:Q3LRW5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005245 ! TP53_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001832 name: TBRG1_HUMAN def: "Transforming growth factor beta regulator 1" [UniProtKB:Q3YBR2] synonym: "Nuclear interactor of ARF and Mdm2" EXACT [UniProtKB:Q3YBR2] xref: EMBL:AAI09270.1 xref: EMBL:AAU10523.1 xref: EMBL:AAZ76016.1 xref: EMBL:BAB55177.1 xref: EMBL:BAB84966.1 xref: EMBL:BAD96656.1 xref: EMBL:CAD28450.1 xref: EMBL:CAH10595.1 xref: UniProtKB:Q3YBR2 xref: UniProtKB:Q53GJ5 xref: UniProtKB:Q66ZJ6 xref: UniProtKB:Q69YS7 xref: UniProtKB:Q8TCS4 xref: UniProtKB:Q8TEI4 xref: UniProtKB:Q96SV0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005745 ! TBRG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001834 name: MAP9_HUMAN def: "Microtubule-associated protein 9" [UniProtKB:Q49MG5] synonym: "Aster-associated protein" EXACT [UniProtKB:Q49MG5] xref: EMBL:AAW02921.1 xref: EMBL:AAY40981.1 xref: EMBL:BAB14978.1 xref: EMBL:BAB15017.1 xref: EMBL:CAH18129.1 xref: UniProtKB:Q49MG5 xref: UniProtKB:Q4W5I7 xref: UniProtKB:Q68DU1 xref: UniProtKB:Q9H781 xref: UniProtKB:Q9H7B6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005022 ! MAP9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012761 ! MAP9_HUMAN-Phosphoserine132 [Term] id: CCO:B0001835 name: FBX43_HUMAN def: "F-box only protein 43" [UniProtKB:Q4G163] synonym: "Endogenous meiotic inhibitor 2" EXACT [UniProtKB:Q4G163] xref: UniProtKB:Q4G163 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004624 ! FBXO43_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0011866 ! FBX43_HUMAN-Phosphoserine76 relationship: transforms_into CCO:B0011867 ! FBX43_HUMAN-Phosphothreonine234 relationship: transforms_into CCO:B0011868 ! FBX43_HUMAN-Phosphoserine334 relationship: transforms_into CCO:B0011869 ! FBX43_HUMAN-Phosphotyrosine503 [Term] id: CCO:B0001836 name: PDCD4_HUMAN def: "Programmed cell death protein 4" [UniProtKB:Q53EL6] synonym: "Neoplastic transformation inhibitor protein" EXACT [UniProtKB:Q53EL6] synonym: "Nuclear antigen H731-like" EXACT [UniProtKB:Q53EL6] synonym: "Protein 197/15a" EXACT [UniProtKB:Q53EL6] xref: EMBL:AAB42218.1 xref: EMBL:AAB67706.1 xref: EMBL:AAH15036.1 xref: EMBL:AAH26104.1 xref: EMBL:AAH31049.1 xref: EMBL:BAD97343.1 xref: EMBL:CAH72815.1 xref: EMBL:CAI40095.1 xref: UniProtKB:O15501 xref: UniProtKB:Q53EL6 xref: UniProtKB:Q5VZS6 xref: UniProtKB:Q6PJI5 xref: UniProtKB:Q8TAR5 xref: UniProtKB:Q99834 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005284 ! PDCD4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013450 ! PDCD4_HUMAN-Phosphoserine76 relationship: transforms_into CCO:B0013451 ! PDCD4_HUMAN-Phosphothreonine93 relationship: transforms_into CCO:B0013452 ! PDCD4_HUMAN-Phosphotyrosine152 relationship: transforms_into CCO:B0013453 ! PDCD4_HUMAN-Phosphoserine457 relationship: transforms_into CCO:B0036020 ! PDCD4_HUMAN-Phosphoserine94 [Term] id: CCO:B0001837 name: CEP55_HUMAN def: "Centrosomal protein of 55 kDa" [UniProtKB:Q53EZ4] synonym: "Cep55" EXACT [UniProtKB:Q53EZ4] synonym: "Up-regulated in colon cancer 6" EXACT [UniProtKB:Q53EZ4] xref: EMBL:AAH08947.1 xref: EMBL:AAX14687.1 xref: EMBL:BAA91670.1 xref: EMBL:BAD97215.1 xref: EMBL:BAE45243.1 xref: EMBL:CAE45837.1 xref: EMBL:CAH72324.1 xref: UniProtKB:Q32WF5 xref: UniProtKB:Q3MV20 xref: UniProtKB:Q53EZ4 xref: UniProtKB:Q5VY28 xref: UniProtKB:Q6N034 xref: UniProtKB:Q96H32 xref: UniProtKB:Q9NVS7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004329 ! CEP55_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005821 ! c10orf3-pom121 physical interaction relationship: participates_in CCO:I0005880 ! c10orf3-tsg101 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011178 ! CEP55_HUMAN-Phosphoserine425 relationship: transforms_into CCO:B0011179 ! CEP55_HUMAN-Phosphoserine428 relationship: transforms_into CCO:B0011180 ! CEP55_HUMAN-Phosphoserine436 [Term] id: CCO:B0001838 name: PKHO1_HUMAN def: "Pleckstrin homology domain-containing family O member 1" [UniProtKB:Q53GL0] synonym: "C-Jun-binding protein" EXACT [UniProtKB:Q53GL0] synonym: "Casein kinase 2-interacting protein 1" EXACT [UniProtKB:Q53GL0] synonym: "CK2-interacting protein-1" EXACT [UniProtKB:Q53GL0] synonym: "CKIP-1" EXACT [UniProtKB:Q53GL0] synonym: "JBP" EXACT [UniProtKB:Q53GL0] xref: EMBL:AAF13461.1 xref: EMBL:AAF89644.1 xref: EMBL:AAH10149.1 xref: EMBL:AAH23533.2 xref: EMBL:AAK28027.1 xref: EMBL:AAK71509.1 xref: EMBL:AAQ13826.1 xref: EMBL:BAD96641.1 xref: EMBL:CAI14264.1 xref: EMBL:EAW53580.1 xref: UniProtKB:Q336K5 xref: UniProtKB:Q53GL0 xref: UniProtKB:Q8IZ51 xref: UniProtKB:Q9NRV3 xref: UniProtKB:Q9UL48 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005328 ! PLEKHO1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001839 name: BOREA_HUMAN def: "Borealin" [UniProtKB:Q53HL2] synonym: "Cell division cycle-associated protein 8" EXACT [UniProtKB:Q53HL2] synonym: "Dasra-B" EXACT [UniProtKB:Q53HL2] synonym: "hDasra-B" EXACT [UniProtKB:Q53HL2] synonym: "Pluripotent embryonic stem cell-related gene 3 protein" EXACT [UniProtKB:Q53HL2] xref: EMBL:AAH00703.1 xref: EMBL:AAH01651.1 xref: EMBL:AAH08079.1 xref: EMBL:AAH16944.1 xref: EMBL:AAR91699.1 xref: EMBL:BAA91629.1 xref: EMBL:BAB13961.1 xref: EMBL:BAB14125.1 xref: EMBL:BAD96269.1 xref: EMBL:BAD96288.1 xref: UniProtKB:Q53HL2 xref: UniProtKB:Q53HN1 xref: UniProtKB:Q96AM3 xref: UniProtKB:Q9NVW5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004182 ! CDCA8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0010823 ! BOREA_HUMAN-Phosphothreonine106 relationship: transforms_into CCO:B0010824 ! BOREA_HUMAN-Phosphoserine165 relationship: transforms_into CCO:B0010825 ! BOREA_HUMAN-Phosphoserine219 [Term] id: CCO:B0001840 name: SGOL2_HUMAN def: "Shugoshin-like 2" [UniProtKB:Q562F6] synonym: "Tripin" EXACT [UniProtKB:Q562F6] xref: EMBL:AAH35764.1 xref: EMBL:AAH48349.1 xref: EMBL:AAH92412.1 xref: EMBL:AAM21971.1 xref: EMBL:AAY24264.1 xref: EMBL:AAY24310.1 xref: EMBL:BAB71617.1 xref: EMBL:BAC04524.1 xref: UniProtKB:Q53RR9 xref: UniProtKB:Q53T20 xref: UniProtKB:Q562F6 xref: UniProtKB:Q86XY4 xref: UniProtKB:Q8IWK2 xref: UniProtKB:Q8IZK1 xref: UniProtKB:Q8N1Q5 xref: UniProtKB:Q96LQ3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005602 ! SGOL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006348 ! ppp2r5a-sgol2-2 physical interaction relationship: participates_in CCO:I0006353 ! sgol1-pp2r1b-ppp2r5a physical interaction relationship: participates_in CCO:I0006761 ! sgol2-ppp2ca-1 physical interaction relationship: participates_in CCO:I0006762 ! sgol2-ppm1a-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014042 ! SGOL2_HUMAN-Phosphoserine266 relationship: transforms_into CCO:B0014043 ! SGOL2_HUMAN-Phosphoserine507 relationship: transforms_into CCO:B0014044 ! SGOL2_HUMAN-Phosphothreonine845 [Term] id: CCO:B0001841 name: ESCO2_HUMAN def: "N-acetyltransferase ESCO2" [UniProtKB:Q56NI9] synonym: "EC 2.3.1.-" EXACT [UniProtKB:Q56NI9] synonym: "ECO1 homolog 2" EXACT [UniProtKB:Q56NI9] synonym: "Establishment of cohesion 1 homolog 2" EXACT [UniProtKB:Q56NI9] xref: EMBL:AAX68677.1 xref: UniProtKB:Q56NI9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004588 ! ESCO2_human relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0001882 ! acyltransferase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011765 ! ESCO2_HUMAN-Phosphoserine29 [Term] id: CCO:B0001842 name: BMCC1_HUMAN def: "BNIP2 motif-containing molecule at the C-terminal region 1" [UniProtKB:Q58A63] xref: EMBL:AAH22571.1 xref: EMBL:AAR15150.1 xref: EMBL:AAR15151.1 xref: EMBL:BAA20822.2 xref: EMBL:BAD93351.1 xref: EMBL:CAI10915.2 xref: EMBL:CAI39750.2 xref: UniProtKB:O15073 xref: UniProtKB:Q58A63 xref: UniProtKB:Q5T476 xref: UniProtKB:Q6T2V6 xref: UniProtKB:Q6T2V7 xref: UniProtKB:Q8N665 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004169 ! BMCC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000313 ! G1 phase relationship: transforms_into CCO:B0010806 ! BMCC1_HUMAN-Phosphoserine217 relationship: transforms_into CCO:B0010807 ! BMCC1_HUMAN-Phosphoserine227 relationship: transforms_into CCO:B0010808 ! BMCC1_HUMAN-Phosphoserine236 relationship: transforms_into CCO:B0010809 ! BMCC1_HUMAN-Phosphoserine238 relationship: transforms_into CCO:B0010810 ! BMCC1_HUMAN-Phosphoserine340 [Term] id: CCO:B0001845 name: Q59FW7_HUMAN def: "Cyclin H variant" [UniProtKB:Q59FW7] xref: EMBL:BAD92579.1 xref: UniProtKB:Q59FW7 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001846 name: Q59GE1_HUMAN def: "Septin" [UniProtKB:Q59GE1] xref: EMBL:BAD92405.1 xref: UniProtKB:Q59GE1 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001847 name: SGOL1_HUMAN def: "Shugoshin-like 1" [UniProtKB:Q5FBB7] synonym: "hSgo1" EXACT [UniProtKB:Q5FBB7] synonym: "Serologically defined breast cancer antigen NY-BR-85" EXACT [UniProtKB:Q5FBB7] xref: EMBL:AAG48266.1 xref: EMBL:AAH01339.2 xref: EMBL:AAH17867.1 xref: EMBL:AAH32696.1 xref: EMBL:BAD89587.1 xref: EMBL:BAD89588.1 xref: EMBL:BAD89589.1 xref: EMBL:BAD89590.1 xref: EMBL:BAD89591.1 xref: EMBL:BAD89592.1 xref: EMBL:BAD91318.1 xref: EMBL:BAD95529.1 xref: EMBL:BAD95530.1 xref: EMBL:BAD95531.1 xref: EMBL:BAD95532.1 xref: EMBL:BAD95533.1 xref: EMBL:BAD95534.1 xref: EMBL:BAD95535.1 xref: EMBL:BAD95536.1 xref: EMBL:BAD95537.1 xref: EMBL:BAD95538.1 xref: EMBL:BAD95539.1 xref: UniProtKB:Q588H5 xref: UniProtKB:Q5FBB4 xref: UniProtKB:Q5FBB5 xref: UniProtKB:Q5FBB6 xref: UniProtKB:Q5FBB7 xref: UniProtKB:Q5FBB8 xref: UniProtKB:Q8N579 xref: UniProtKB:Q8WVL0 xref: UniProtKB:Q9BVA8 xref: UniProtKB:Q9H275 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005601 ! SGOL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006347 ! ppp2r5d-sgol1-1 physical interaction relationship: participates_in CCO:I0006558 ! ppp2r5a-sgol1-1 physical interaction relationship: participates_in CCO:I0006758 ! sgol1-ppp2ca-1 physical interaction relationship: participates_in CCO:I0006759 ! sgol1-ppm1a-1 physical interaction relationship: participates_in CCO:I0006760 ! sgol1-ppp2r5a-1 physical interaction relationship: participates_in CCO:I0007297 ! sgol1-ppp2r5a-2 colocalization relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:B0001848 name: ESCO1_HUMAN def: "N-acetyltransferase ESCO1" [UniProtKB:Q5FWF5] synonym: "CTF7 homolog 1" EXACT [UniProtKB:Q5FWF5] synonym: "EC 2.3.1.-" EXACT [UniProtKB:Q5FWF5] synonym: "ECO1 homolog 1" EXACT [UniProtKB:Q5FWF5] synonym: "EFO1p" EXACT [UniProtKB:Q5FWF5] synonym: "ESO1 homolog 1" EXACT [UniProtKB:Q5FWF5] synonym: "Establishment factor-like protein 1" EXACT [UniProtKB:Q5FWF5] synonym: "Establishment of cohesion 1 homolog 1" EXACT [UniProtKB:Q5FWF5] synonym: "hEFO1" EXACT [UniProtKB:Q5FWF5] xref: EMBL:AAH36943.1 xref: EMBL:AAH89426.1 xref: EMBL:BAB67804.1 xref: EMBL:BAC03483.1 xref: EMBL:CAH10584.1 xref: EMBL:CAH10682.1 xref: EMBL:DAA02068.1 xref: UniProtKB:Q5FWF5 xref: UniProtKB:Q69YG4 xref: UniProtKB:Q69YS3 xref: UniProtKB:Q6IMD7 xref: UniProtKB:Q8N3Z5 xref: UniProtKB:Q8NBG2 xref: UniProtKB:Q96PX7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004587 ! ESCO1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011764 ! ESCO1_HUMAN-Phosphoserine31 [Term] id: CCO:B0001861 name: SPDYC_HUMAN def: "Speedy protein C" [UniProtKB:Q5MJ68] synonym: "hSpy/Ringo C" EXACT [UniProtKB:Q5MJ68] synonym: "Rapid inducer of G2/M progression in oocytes C" EXACT [UniProtKB:Q5MJ68] synonym: "RINGO C" EXACT [UniProtKB:Q5MJ68] xref: EMBL:AAW30396.1 xref: UniProtKB:Q5MJ68 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005657 ! SPDYC_human relationship: has_function CCO:F0004210 ! protein kinase binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001862 name: SPDYA_HUMAN def: "Speedy protein A" [UniProtKB:Q5MJ70] synonym: "hSpy/Ringo A" EXACT [UniProtKB:Q5MJ70] synonym: "Rapid inducer of G2/M progression in oocytes A" EXACT [UniProtKB:Q5MJ70] synonym: "RINGO A" EXACT [UniProtKB:Q5MJ70] synonym: "Speedy-1" EXACT [UniProtKB:Q5MJ70] synonym: "Spy1" EXACT [UniProtKB:Q5MJ70] xref: EMBL:AAH93005.1 xref: EMBL:AAW30394.1 xref: EMBL:AAW30395.1 xref: EMBL:AAY24014.1 xref: UniProtKB:Q53R05 xref: UniProtKB:Q5MJ69 xref: UniProtKB:Q5MJ70 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005656 ! SPDYA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001867 name: Q5T179_HUMAN def: "CDC28 protein kinase regulatory subunit 1B" [UniProtKB:Q5T179] xref: EMBL:CAI13255.1 xref: UniProtKB:Q5T179 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004364 ! CKS1B_human relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003204 ! cyclin-dependent protein kinase regulator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001872 name: Q5T317_HUMAN def: "p53 regulated PA26 nuclear protein" [UniProtKB:Q5T317] synonym: "PA26-T1" EXACT [UniProtKB:Q5T317] xref: EMBL:CAI16719.1 xref: UniProtKB:Q5T317 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005997 ! RP11-787I22.2-003_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001875 name: HECD3_HUMAN def: "Probable E3 ubiquitin-protein ligase HECTD3" [UniProtKB:Q5T447] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q5T447] synonym: "HECT domain-containing protein 3" EXACT [UniProtKB:Q5T447] xref: EMBL:AAH19105.1 xref: EMBL:BAB15015.1 xref: EMBL:CAI16437.1 xref: EMBL:CAI16438.1 xref: UniProtKB:Q5T447 xref: UniProtKB:Q5T448 xref: UniProtKB:Q9H783 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004797 ! HECTD3_human relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003433 ! ligase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000282 ! anaphase-promoting complex relationship: participates_in CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition [Term] id: CCO:B0001879 name: AVPI1_HUMAN def: "Arginine vasopressin-induced protein 1" [UniProtKB:Q5T686] synonym: "AVP-induced protein 1" EXACT [UniProtKB:Q5T686] xref: EMBL:AAG17261.1 xref: EMBL:AAG44474.1 xref: EMBL:AAH00877.1 xref: EMBL:BAD96213.1 xref: EMBL:BAD96819.1 xref: EMBL:CAI15464.1 xref: UniProtKB:Q53G32 xref: UniProtKB:Q5T686 xref: UniProtKB:Q9H2R9 xref: UniProtKB:Q9HBN9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004131 ! AVPI1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001882 name: UT14C_HUMAN def: "U3 small nucleolar RNA-associated protein 14 homolog C" [UniProtKB:Q5TAP6] xref: EMBL:AAH89407.1 xref: EMBL:BAA13396.2 xref: EMBL:CAI12891.1 xref: UniProtKB:Q5FWG3 xref: UniProtKB:Q5TAP6 xref: UniProtKB:Q92555 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005890 ! UTP14C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0001883 name: QN1_HUMAN def: "Protein QN1 homolog" [UniProtKB:Q5TB80] xref: EMBL:AAH63632.1 xref: EMBL:BAA76853.2 xref: EMBL:CAI22698.2 xref: EMBL:CAO03537.1 xref: EMBL:CAO03538.1 xref: UniProtKB:A6PVL7 xref: UniProtKB:A6PVL8 xref: UniProtKB:Q5TB80 xref: UniProtKB:Q6P475 xref: UniProtKB:Q9Y2L2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005405 ! KIAA1009_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013653 ! QN1_HUMAN-Phosphoserine770 relationship: transforms_into CCO:B0013654 ! QN1_HUMAN-Phosphoserine776 [Term] id: CCO:B0001884 name: Q5TBT1_HUMAN def: "Dystonin" [UniProtKB:Q5TBT1] xref: EMBL:CAI14342.1 xref: EMBL:CAI14988.1 xref: EMBL:CAI16608.1 xref: EMBL:CAI20331.1 xref: EMBL:CAI22043.1 xref: UniProtKB:Q5TBT1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004183 ! DST_human relationship: has_function CCO:F0000323 ! actin binding relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006581 ! dtnbp1-bpag1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001885 name: Q5TBT2_HUMAN def: "Dystonin" [UniProtKB:Q5TBT2] xref: EMBL:CAI14341.1 xref: EMBL:CAI14989.1 xref: EMBL:CAI16609.1 xref: EMBL:CAI20330.1 xref: EMBL:CAI22044.1 xref: UniProtKB:Q5TBT2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004183 ! DST_human relationship: has_function CCO:F0000323 ! actin binding relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001886 name: Q5TCH6_HUMAN def: "SPO11 meiotic protein covalently bound to DSB homolog" [UniProtKB:Q5TCH6] synonym: "S. cerevisiae" EXACT [UniProtKB:Q5TCH6] xref: EMBL:CAI21519.2 xref: UniProtKB:Q5TCH6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005664 ! SPO11_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000296 ! chromosome relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001887 name: Q5TCH7_HUMAN def: "SPO11 meiotic protein covalently bound to DSB homolog" [UniProtKB:Q5TCH7] synonym: "S. cerevisiae" EXACT [UniProtKB:Q5TCH7] xref: EMBL:CAI21520.1 xref: UniProtKB:Q5TCH7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005664 ! SPO11_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000296 ! chromosome relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0001888 name: Q5TCY3_HUMAN def: "Novel protein" [UniProtKB:Q5TCY3] synonym: "P53-associated parkin-like cytoplasmic protein, isoform CRA_a" EXACT [UniProtKB:Q5TCY3] xref: EMBL:CAI20204.1 xref: EMBL:EAX04163.1 xref: UniProtKB:Q5TCY3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006002 ! RP3-330M21.2_human relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0004689 ! ubiquitin protein ligase binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000282 ! anaphase-promoting complex relationship: located_in CCO:C0001248 ! cullin-RING ubiquitin ligase complex relationship: participates_in CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition [Term] id: CCO:B0001894 name: LIN9_HUMAN def: "Lin-9 homolog" [UniProtKB:Q5TKA1] synonym: "Beta subunit-associated regulator of apoptosis" EXACT [UniProtKB:Q5TKA1] synonym: "hLin-9" EXACT [UniProtKB:Q5TKA1] synonym: "huLin-9" EXACT [UniProtKB:Q5TKA1] synonym: "pRB-associated protein" EXACT [UniProtKB:Q5TKA1] synonym: "TUDOR gene similar protein" EXACT [UniProtKB:Q5TKA1] synonym: "Type I interferon receptor beta chain-associated protein" EXACT [UniProtKB:Q5TKA1] xref: EMBL:AAH43444.1 xref: EMBL:AAH45625.1 xref: EMBL:AAQ13710.1 xref: EMBL:AAQ13711.1 xref: EMBL:AAV41873.1 xref: EMBL:BAC86475.1 xref: EMBL:CAD97871.1 xref: UniProtKB:Q5TKA1 xref: UniProtKB:Q5U5L8 xref: UniProtKB:Q5U7E1 xref: UniProtKB:Q6PI55 xref: UniProtKB:Q6ZTV4 xref: UniProtKB:Q7Z3J1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004981 ! LIN9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0012701 ! LIN9_HUMAN-Phosphoserine309 [Term] id: CCO:B0001895 name: CROCC_HUMAN def: "Rootletin" [UniProtKB:Q5TZA2] synonym: "Ciliary rootlet coiled-coil protein" EXACT [UniProtKB:Q5TZA2] xref: EMBL:AAP85633.1 xref: EMBL:ABA43896.1 xref: EMBL:BAA32290.2 xref: EMBL:CAH70055.1 xref: EMBL:CAI20363.1 xref: EMBL:DAA05505.1 xref: UniProtKB:Q2VHY3 xref: UniProtKB:Q5TZA2 xref: UniProtKB:Q66GT7 xref: UniProtKB:Q7Z2L4 xref: UniProtKB:Q7Z5D7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004399 ! CROCC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011349 ! CROCC_HUMAN-Phosphoserine1619 [Term] id: CCO:B0001896 name: Q5TZP9_HUMAN def: "Cyclin B1" [UniProtKB:Q5TZP9] xref: EMBL:AAV38930.1 xref: UniProtKB:Q5TZP9 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001897 name: RIF1_HUMAN def: "Telomere-associated protein RIF1" [UniProtKB:Q5UIP0] synonym: "Rap1-interacting factor 1 homolog" EXACT [UniProtKB:Q5UIP0] xref: EMBL:AAB50209.1 xref: EMBL:AAS94233.1 xref: EMBL:AAT40745.1 xref: EMBL:AAV51401.1 xref: EMBL:AAV51402.1 xref: EMBL:AAV51403.1 xref: EMBL:AAV51404.1 xref: EMBL:BAA91705.1 xref: EMBL:BAB14313.1 xref: EMBL:BAB14792.1 xref: EMBL:BAB85058.1 xref: EMBL:CAB45727.1 xref: EMBL:CAI45961.1 xref: UniProtKB:A6NC27 xref: UniProtKB:Q5H9R3 xref: UniProtKB:Q5UIP0 xref: UniProtKB:Q5UIP2 xref: UniProtKB:Q66YK6 xref: UniProtKB:Q6PRU2 xref: UniProtKB:Q8TE94 xref: UniProtKB:Q99772 xref: UniProtKB:Q9H830 xref: UniProtKB:Q9H9B9 xref: UniProtKB:Q9NVP5 xref: UniProtKB:Q9Y4R4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005489 ! RIF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007984 ! cpe-rif1 physical interaction relationship: participates_in CCO:I0007990 ! rpa2-rif1 physical interaction relationship: participates_in CCO:I0007991 ! selenbp1-rif1 physical interaction relationship: participates_in CCO:I0008002 ! cdc42-rif1 physical interaction relationship: participates_in CCO:I0008005 ! cdkn2c-rif1 physical interaction relationship: participates_in CCO:I0008008 ! cox17-rif1 physical interaction relationship: participates_in CCO:I0008014 ! hrmt1l2-rif1 physical interaction relationship: participates_in CCO:I0008015 ! hspe1-rif1 physical interaction relationship: participates_in CCO:I0008017 ! lama4-rif1 physical interaction relationship: participates_in CCO:I0008024 ! mrps12-rif1 physical interaction relationship: participates_in CCO:I0008025 ! naca-rif1 physical interaction relationship: participates_in CCO:I0008027 ! np-rif1 physical interaction relationship: participates_in CCO:I0008028 ! pafah1b3-rif1 physical interaction relationship: participates_in CCO:I0008031 ! polr2c-rif1 physical interaction relationship: participates_in CCO:I0008032 ! polr3f-rif1 physical interaction relationship: participates_in CCO:I0008036 ! psmd11-rif1 physical interaction relationship: participates_in CCO:I0008038 ! psmd2-rif1 physical interaction relationship: participates_in CCO:I0008042 ! rfc5-rif1 physical interaction relationship: participates_in CCO:I0008046 ! rplp1-rif1 physical interaction relationship: participates_in CCO:I0008047 ! sat-rif1 physical interaction relationship: participates_in CCO:I0008050 ! serpinb9-rif1 physical interaction relationship: participates_in CCO:I0008053 ! smn1-rif1 physical interaction relationship: participates_in CCO:I0008058 ! tk1-rif1 physical interaction relationship: participates_in CCO:I0008062 ! znf24-rif1 physical interaction relationship: participates_in CCO:I0008063 ! akr1c3-rif1 physical interaction relationship: participates_in CCO:I0008064 ! ankrd24-rif1 physical interaction relationship: participates_in CCO:I0008067 ! arl3-rif1 physical interaction relationship: participates_in CCO:I0008073 ! bmi1-rif1 physical interaction relationship: participates_in CCO:I0008075 ! cbx1-rif1 physical interaction relationship: participates_in CCO:I0008086 ! cetn3-rif1 physical interaction relationship: participates_in CCO:I0008088 ! ckmt2-rif1 physical interaction relationship: participates_in CCO:I0008101 ! dnmt2-rif1 physical interaction relationship: participates_in CCO:I0008107 ! fxr1-rif1 physical interaction relationship: participates_in CCO:I0008113 ! gstm4-rif1 physical interaction relationship: participates_in CCO:I0008116 ! hbxip-rif1 physical interaction relationship: participates_in CCO:I0008117 ! hla_dqa1-rif1 physical interaction relationship: participates_in CCO:I0008119 ! hmgb1-rif1 physical interaction relationship: participates_in CCO:I0008120 ! hmox2-rif1 physical interaction relationship: participates_in CCO:I0008123 ! hspb1-rif1 physical interaction relationship: participates_in CCO:I0008125 ! id2-rif1 physical interaction relationship: participates_in CCO:I0008134 ! mphosph6-rif1 physical interaction relationship: participates_in CCO:I0008140 ! pcdha4-rif1 physical interaction relationship: participates_in CCO:I0008141 ! pdcd5-rif1 physical interaction relationship: participates_in CCO:I0008146 ! pfdn1-rif1 physical interaction relationship: participates_in CCO:I0008148 ! pfn1-rif1 physical interaction relationship: participates_in CCO:I0008153 ! prei3-rif1 physical interaction relationship: participates_in CCO:I0008154 ! psg9-rif1 physical interaction relationship: participates_in CCO:I0008156 ! rbm5-rif1 physical interaction relationship: participates_in CCO:I0008159 ! s100a8-rif1 physical interaction relationship: participates_in CCO:I0008164 ! snrpn-rif1 physical interaction relationship: participates_in CCO:I0008169 ! sult1e1-rif1 physical interaction relationship: participates_in CCO:I0008175 ! tmsb4x-rif1 physical interaction relationship: participates_in CCO:I0008186 ! vim-rif1 physical interaction relationship: participates_in CCO:I0008188 ! klhlx-rif1 physical interaction relationship: participates_in CCO:I0008189 ! arhh-rif1 physical interaction relationship: participates_in CCO:I0008192 ! atf3-rif1 physical interaction relationship: participates_in CCO:I0008193 ! atp1b1-rif1 physical interaction relationship: participates_in CCO:I0008203 ! brms1-rif1 physical interaction relationship: participates_in CCO:I0008205 ! c19orf14-rif1 physical interaction relationship: participates_in CCO:I0008217 ! cradd-rif1 physical interaction relationship: participates_in CCO:I0008231 ! ethe1-rif1 physical interaction relationship: participates_in CCO:I0008241 ! smpd3-rif1 physical interaction relationship: participates_in CCO:I0008244 ! gc-rif1 physical interaction relationship: participates_in CCO:I0008249 ! hspb3-rif1 physical interaction relationship: participates_in CCO:I0008250 ! hspbp1-rif1 physical interaction relationship: participates_in CCO:I0008252 ! itgb3bp-rif1 physical interaction relationship: participates_in CCO:I0008254 ! kibra-rif1 physical interaction relationship: participates_in CCO:I0008262 ! mad2l1bp-rif1 physical interaction relationship: participates_in CCO:I0008267 ! mllt3-rif1 physical interaction relationship: participates_in CCO:I0008271 ! mnat1-rif1 physical interaction relationship: participates_in CCO:I0008276 ! mrps6-rif1 physical interaction relationship: participates_in CCO:I0008283 ! nhp2l1-rif1 physical interaction relationship: participates_in CCO:I0008284 ! paep-rif1 physical interaction relationship: participates_in CCO:I0008290 ! plekha4-rif1 physical interaction relationship: participates_in CCO:I0008298 ! pqbp1-rif1 physical interaction relationship: participates_in CCO:I0008306 ! rab27a-rif1 physical interaction relationship: participates_in CCO:I0008314 ! rit1-rif1 physical interaction relationship: participates_in CCO:I0008315 ! rnf10-rif1 physical interaction relationship: participates_in CCO:I0008317 ! rpl37a-rif1 physical interaction relationship: participates_in CCO:I0008318 ! rrm1-rif1 physical interaction relationship: participates_in CCO:I0008323 ! spg7-rif1 physical interaction relationship: participates_in CCO:I0008326 ! stx5a-rif1 physical interaction relationship: participates_in CCO:I0008336 ! tdgf1-rif1 physical interaction relationship: participates_in CCO:I0008339 ! tgif-rif1 physical interaction relationship: participates_in CCO:I0008340 ! tm4sf6-rif1 physical interaction relationship: participates_in CCO:I0008341 ! tnfrsf6-rif1 physical interaction relationship: participates_in CCO:I0008346 ! trbv21_1-rif1 physical interaction relationship: participates_in CCO:I0008349 ! ube2v2-rif1 physical interaction relationship: participates_in CCO:I0008362 ! boc-rif1 physical interaction relationship: participates_in CCO:I0008402 ! klk10-rif1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013860 ! RIF1_HUMAN-Phosphoserine782 relationship: transforms_into CCO:B0013861 ! RIF1_HUMAN-Phosphoserine1454 relationship: transforms_into CCO:B0013862 ! RIF1_HUMAN-Phosphoserine1513 relationship: transforms_into CCO:B0013863 ! RIF1_HUMAN-Phosphothreonine1518 relationship: transforms_into CCO:B0013864 ! RIF1_HUMAN-Phosphoserine1542 relationship: transforms_into CCO:B0013865 ! RIF1_HUMAN-Phosphoserine1579 relationship: transforms_into CCO:B0013866 ! RIF1_HUMAN-Phosphoserine1688 relationship: transforms_into CCO:B0013867 ! RIF1_HUMAN-Phosphoserine1851 relationship: transforms_into CCO:B0013868 ! RIF1_HUMAN-Phosphoserine2161 relationship: transforms_into CCO:B0013869 ! RIF1_HUMAN-Phosphoserine2243 [Term] id: CCO:B0001898 name: GFI1B_HUMAN def: "Zinc finger protein Gfi-1b" [UniProtKB:Q5VTD9] synonym: "Growth factor independent protein 1B" EXACT [UniProtKB:Q5VTD9] synonym: "Potential regulator of CDKN1A translocated in CML" EXACT [UniProtKB:Q5VTD9] xref: EMBL:AAD08672.1 xref: EMBL:AAH43371.1 xref: EMBL:AAR06639.1 xref: EMBL:CAG38783.1 xref: EMBL:CAH73618.1 xref: EMBL:CAH73619.1 xref: EMBL:EAW88025.1 xref: UniProtKB:O95270 xref: UniProtKB:Q5VTD8 xref: UniProtKB:Q5VTD9 xref: UniProtKB:Q6FHZ2 xref: UniProtKB:Q6T888 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004694 ! GFI1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006216 ! cenpj-gfi1b physical interaction relationship: participates_in CCO:I0006217 ! gfi1b-jag2 physical interaction relationship: participates_in CCO:I0006218 ! gfi1b-nell2 physical interaction relationship: participates_in CCO:I0006650 ! znrd1-gfi1b physical interaction relationship: participates_in CCO:I0006658 ! gfi1b-cops5 physical interaction relationship: participates_in CCO:I0006659 ! gfi1b-ccdc85b physical interaction relationship: participates_in CCO:I0006660 ! gfi1b-begain-1 physical interaction relationship: participates_in CCO:I0006661 ! gfi1b-ushbp1 physical interaction relationship: participates_in CCO:I0007630 ! gfi1b-actn1 physical interaction relationship: participates_in CCO:I0007631 ! gfi1b-agrn physical interaction relationship: participates_in CCO:I0007632 ! gfi1b-becn1 physical interaction relationship: participates_in CCO:I0007633 ! gfi1b-brca1 physical interaction relationship: participates_in CCO:I0007634 ! gfi1b-bre physical interaction relationship: participates_in CCO:I0007635 ! gfi1b-c20orf12 physical interaction relationship: participates_in CCO:I0007636 ! gfi1b-cenpb physical interaction relationship: participates_in CCO:I0007637 ! gfi1b-cenpj physical interaction relationship: participates_in CCO:I0007638 ! gfi1b-dkfzp586m1819 physical interaction relationship: participates_in CCO:I0007639 ! gfi1b-dtna physical interaction relationship: participates_in CCO:I0007640 ! gfi1b-efemp1 physical interaction relationship: participates_in CCO:I0007641 ! gfi1b-efemp2 physical interaction relationship: participates_in CCO:I0007642 ! gfi1b-megf6 physical interaction relationship: participates_in CCO:I0007643 ! gfi1b-megf8 physical interaction relationship: participates_in CCO:I0007644 ! gfi1b-egfl7 physical interaction relationship: participates_in CCO:I0007645 ! gfi1b-fbln1 physical interaction relationship: participates_in CCO:I0007646 ! gfi1b-grip2 physical interaction relationship: participates_in CCO:I0007647 ! gfi1b-grn physical interaction relationship: participates_in CCO:I0007648 ! gfi1b-hecw1 physical interaction relationship: participates_in CCO:I0007649 ! gfi1b-hgs physical interaction relationship: participates_in CCO:I0007650 ! gfi1b-hnrpk physical interaction relationship: participates_in CCO:I0007651 ! gfi1b-hom_tes_103 physical interaction relationship: participates_in CCO:I0007652 ! gfi1b-hspg2 physical interaction relationship: participates_in CCO:I0007653 ! gfi1b-jag2-1 physical interaction relationship: participates_in CCO:I0007654 ! gfi1b-begain physical interaction relationship: participates_in CCO:I0007655 ! gfi1b-anks3 physical interaction relationship: participates_in CCO:I0007656 ! gfi1b-kif17 physical interaction relationship: participates_in CCO:I0007657 ! gfi1b-lamb1 physical interaction relationship: participates_in CCO:I0007658 ! gfi1b-lzts2 physical interaction relationship: participates_in CCO:I0007659 ! gfi1b-matr3 physical interaction relationship: participates_in CCO:I0007660 ! gfi1b-mid2 physical interaction relationship: participates_in CCO:I0007661 ! gfi1b-mon1a physical interaction relationship: participates_in CCO:I0007662 ! gfi1b-myh14 physical interaction relationship: participates_in CCO:I0007663 ! gfi1b-nelf physical interaction relationship: participates_in CCO:I0007664 ! gfi1b-nell1 physical interaction relationship: participates_in CCO:I0007665 ! gfi1b-nell2-1 physical interaction relationship: participates_in CCO:I0007666 ! gfi1b-notch1 physical interaction relationship: participates_in CCO:I0007667 ! gfi1b-pde4dip physical interaction relationship: participates_in CCO:I0007668 ! gfi1b-enh physical interaction relationship: participates_in CCO:I0007669 ! gfi1b-pdzk4 physical interaction relationship: participates_in CCO:I0007670 ! gfi1b-phc2 physical interaction relationship: participates_in CCO:I0007671 ! gfi1b-prkcabp physical interaction relationship: participates_in CCO:I0007672 ! gfi1b-rab11fip4 physical interaction relationship: participates_in CCO:I0007673 ! gfi1b-rchy1 physical interaction relationship: participates_in CCO:I0007674 ! gfi1b-rfp physical interaction relationship: participates_in CCO:I0007675 ! gfi1b-rint1 physical interaction relationship: participates_in CCO:I0007676 ! gfi1b-rnf31 physical interaction relationship: participates_in CCO:I0007678 ! gfi1b-taf1 physical interaction relationship: participates_in CCO:I0007679 ! gfi1b-tmf1 physical interaction relationship: participates_in CCO:I0007680 ! gfi1b-trip6 physical interaction relationship: participates_in CCO:I0007681 ! gfi1b-vsnl1 physical interaction relationship: participates_in CCO:I0007682 ! gfi1b-actn1-1 physical interaction relationship: participates_in CCO:I0007683 ! gfi1b-aes physical interaction relationship: participates_in CCO:I0007684 ! gfi1b-atxn2 physical interaction relationship: participates_in CCO:I0007685 ! gfi1b-dnaja3 physical interaction relationship: participates_in CCO:I0007686 ! gfi1b-efemp1-1 physical interaction relationship: participates_in CCO:I0007687 ! gfi1b-efemp2-1 physical interaction relationship: participates_in CCO:I0007688 ! gfi1b-fbln5 physical interaction relationship: participates_in CCO:I0007689 ! gfi1b-jub physical interaction relationship: participates_in CCO:I0007690 ! gfi1b-prkcabp-1 physical interaction relationship: participates_in CCO:I0007691 ! gfi1b-psma3 physical interaction relationship: participates_in CCO:I0007692 ! gfi1b-traf1 physical interaction relationship: participates_in CCO:I0007693 ! gfi1b-trip6-1 physical interaction relationship: participates_in CCO:I0007694 ! gfi1b-txndc11 physical interaction relationship: participates_in CCO:P0000024 ! G1-specific transcription in mitotic cell cycle relationship: transforms_into CCO:B0011929 ! GFI1B_HUMAN-Phosphoserine261 [Term] id: CCO:B0001899 name: DAB2P_HUMAN def: "Disabled homolog 2-interacting protein" [UniProtKB:Q5VWQ8] synonym: "ASK-interacting protein 1" EXACT [UniProtKB:Q5VWQ8] synonym: "DAB2 interaction protein" EXACT [UniProtKB:Q5VWQ8] synonym: "DAB2-interacting protein" EXACT [UniProtKB:Q5VWQ8] xref: EMBL:AAI46763.1 xref: EMBL:AAK50336.1 xref: EMBL:AAM00371.1 xref: EMBL:BAB21834.2 xref: EMBL:CAH72155.2 xref: EMBL:CAH72158.1 xref: UniProtKB:A6H8V2 xref: UniProtKB:Q5VWQ8 xref: UniProtKB:Q8TDL2 xref: UniProtKB:Q96SE1 xref: UniProtKB:Q9C0C0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004433 ! DAB2IP_human relationship: has_function CCO:F0001401 ! GTPase activator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000766 ! membrane relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011422 ! DAB2P_HUMAN-Phosphoserine702 [Term] id: CCO:B0001900 name: Q5VXJ5_HUMAN def: "Synaptonemal complex protein 1" [UniProtKB:Q5VXJ5] xref: EMBL:CAH72848.1 xref: UniProtKB:Q5VXJ5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005710 ! SYCP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000122 ! synaptonemal complex relationship: participates_in CCO:P0000121 ! synaptonemal complex assembly [Term] id: CCO:B0001901 name: Q5W161_HUMAN def: "Septin" [UniProtKB:Q5W161] xref: EMBL:CAH72053.1 xref: UniProtKB:Q5W161 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006003 ! RP11-291L22.2-003_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001902 name: POLS_HUMAN def: "DNA polymerase sigma" [UniProtKB:Q5XG87] synonym: "DNA polymerase kappa" EXACT [UniProtKB:Q5XG87] synonym: "EC 2.7.7.7" EXACT [UniProtKB:Q5XG87] synonym: "LAK-1" EXACT [UniProtKB:Q5XG87] synonym: "Topoisomerase-related function protein 4-1" EXACT [UniProtKB:Q5XG87] synonym: "TRF4-1" EXACT [UniProtKB:Q5XG87] xref: EMBL:AAD45198.1 xref: EMBL:AAH84567.2 xref: EMBL:AAI17138.1 xref: EMBL:AAI26107.1 xref: EMBL:AAT38110.1 xref: EMBL:BAA24434.2 xref: UniProtKB:O43289 xref: UniProtKB:Q17RZ1 xref: UniProtKB:Q5XG87 xref: UniProtKB:Q9Y6C1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005354 ! POLS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000076 ! sister chromatid cohesion relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation [Term] id: CCO:B0001903 name: STEA3_HUMAN def: "Metalloreductase STEAP3" [UniProtKB:Q658P3] synonym: "Dudulin-2" EXACT [UniProtKB:Q658P3] synonym: "EC 1.16.1.-" EXACT [UniProtKB:Q658P3] synonym: "hpHyde" EXACT [UniProtKB:Q658P3] synonym: "hTSAP6" EXACT [UniProtKB:Q658P3] synonym: "pHyde" EXACT [UniProtKB:Q658P3] synonym: "Six-transmembrane epithelial antigen of prostate 3" EXACT [UniProtKB:Q658P3] synonym: "Tumor suppressor-activated pathway protein 6" EXACT [UniProtKB:Q658P3] xref: EMBL:AAH42150.1 xref: EMBL:AAH95421.2 xref: EMBL:AAK50538.1 xref: EMBL:AAL78206.1 xref: EMBL:AAM08128.1 xref: EMBL:AAM45136.1 xref: EMBL:AAO38238.1 xref: EMBL:AAQ04065.1 xref: EMBL:AAX88963.1 xref: EMBL:AAY14872.1 xref: EMBL:BAA91839.1 xref: EMBL:CAD97986.1 xref: EMBL:CAH56204.1 xref: UniProtKB:Q4VBR2 xref: UniProtKB:Q4ZG36 xref: UniProtKB:Q53SQ8 xref: UniProtKB:Q658P3 xref: UniProtKB:Q7Z389 xref: UniProtKB:Q86SF6 xref: UniProtKB:Q8NEW6 xref: UniProtKB:Q8TDP3 xref: UniProtKB:Q8TF03 xref: UniProtKB:Q9NVB5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005690 ! STEAP3_human relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0001643 ! iron ion binding relationship: has_function CCO:F0001644 ! copper ion binding relationship: has_function CCO:F0002378 ! electron carrier activity relationship: has_function CCO:F0003172 ! oxidoreductase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_function CCO:F0007986 ! FAD binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000351 ! endosome relationship: located_in CCO:C0000713 ! endosome membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014249 ! STEA3_HUMAN-Phosphoserine20 [Term] id: CCO:B0001904 name: KCD11_HUMAN def: "BTB/POZ domain-containing protein KCTD11" [UniProtKB:Q693B1] xref: EMBL:AAI10599.1 xref: EMBL:AAT75307.1 xref: UniProtKB:Q693B1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004933 ! KCTD11_human relationship: has_function CCO:F0001517 ! voltage-gated potassium channel activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000527 ! voltage-gated potassium channel complex relationship: located_in CCO:C0000766 ! membrane relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001905 name: CDCA2_HUMAN def: "Cell division cycle-associated protein 2" [UniProtKB:Q69YH5] synonym: "Recruits PP1 onto mitotic chromatin at anaphase protein" EXACT [UniProtKB:Q69YH5] synonym: "Repo-Man" EXACT [UniProtKB:Q69YH5] xref: EMBL:AAH36214.1 xref: EMBL:AAH63651.1 xref: EMBL:AAH85609.1 xref: EMBL:AAI04451.1 xref: EMBL:AAI04452.1 xref: EMBL:BAC05374.1 xref: EMBL:CAH10577.1 xref: EMBL:CAH10585.1 xref: UniProtKB:Q3SX74 xref: UniProtKB:Q4G0W0 xref: UniProtKB:Q5RKN0 xref: UniProtKB:Q69YH5 xref: UniProtKB:Q69YI4 xref: UniProtKB:Q6P464 xref: UniProtKB:Q8N7C1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004295 ! CDCA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011088 ! CDCA2_HUMAN-Phosphoserine99 relationship: transforms_into CCO:B0011089 ! CDCA2_HUMAN-Phosphoserine292 relationship: transforms_into CCO:B0011090 ! CDCA2_HUMAN-Phosphoserine336 relationship: transforms_into CCO:B0011091 ! CDCA2_HUMAN-Phosphoserine401 [Term] id: CCO:B0001906 name: CYTSA_HUMAN def: "Cytospin-A" [UniProtKB:Q69YQ0] synonym: "Renal carcinoma antigen NY-REN-22" EXACT [UniProtKB:Q69YQ0] synonym: "SPECC1-like protein" EXACT [UniProtKB:Q69YQ0] xref: EMBL:AAX84184.1 xref: EMBL:BAA21574.1 xref: EMBL:CAH10609.1 xref: UniProtKB:O15081 xref: UniProtKB:Q69YQ0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004432 ! SPECC1L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011420 ! CYTSA_HUMAN-Phosphoserine54 relationship: transforms_into CCO:B0011421 ! CYTSA_HUMAN-Phosphoserine220 [Term] id: CCO:B0001907 name: WBP2L_HUMAN def: "Postacrosomal sheath WW domain-binding protein" [UniProtKB:Q6ICG8] synonym: "WW domain-binding protein 2-like" EXACT [UniProtKB:Q6ICG8] xref: EMBL:AAH22546.1 xref: EMBL:AAH22549.1 xref: EMBL:AAQ02873.1 xref: EMBL:CAG30286.1 xref: EMBL:CAI41694.1 xref: UniProtKB:A3KFF7 xref: UniProtKB:Q6ICG8 xref: UniProtKB:Q8TBF0 xref: UniProtKB:Q8TBF3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005913 ! WBP2NL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0001908 name: NIPBL_HUMAN def: "Nipped-B-like protein" [UniProtKB:Q6KC79] synonym: "Delangin" EXACT [UniProtKB:Q6KC79] synonym: "SCC2 homolog" EXACT [UniProtKB:Q6KC79] xref: EMBL:AAH33847.1 xref: EMBL:BAA77335.1 xref: EMBL:BAA77349.1 xref: EMBL:BAC86701.1 xref: EMBL:CAD98051.1 xref: EMBL:CAD98052.1 xref: EMBL:CAE45790.1 xref: EMBL:CAF25290.1 xref: EMBL:CAG26691.1 xref: UniProtKB:Q6KC79 xref: UniProtKB:Q6KCD6 xref: UniProtKB:Q6N080 xref: UniProtKB:Q6ZT92 xref: UniProtKB:Q7Z2E6 xref: UniProtKB:Q8N4M5 xref: UniProtKB:Q9Y6Y3 xref: UniProtKB:Q9Y6Y4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005196 ! NIPBL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008465 ! dbn1-nipbl physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013180 ! NIPBL_HUMAN-Phosphoserine280 relationship: transforms_into CCO:B0013181 ! NIPBL_HUMAN-Phosphoserine318 relationship: transforms_into CCO:B0013182 ! NIPBL_HUMAN-Phosphoserine553 relationship: transforms_into CCO:B0013183 ! NIPBL_HUMAN-Phosphothreonine558 relationship: transforms_into CCO:B0013184 ! NIPBL_HUMAN-Phosphothreonine646 relationship: transforms_into CCO:B0013185 ! NIPBL_HUMAN-Phosphothreonine746 relationship: transforms_into CCO:B0013186 ! NIPBL_HUMAN-Phosphoserine849 relationship: transforms_into CCO:B0013187 ! NIPBL_HUMAN-Phosphoserine850 relationship: transforms_into CCO:B0013188 ! NIPBL_HUMAN-Phosphoserine912 relationship: transforms_into CCO:B0013189 ! NIPBL_HUMAN-Phosphothreonine914 relationship: transforms_into CCO:B0013190 ! NIPBL_HUMAN-Phosphoserine1089 relationship: transforms_into CCO:B0013191 ! NIPBL_HUMAN-Phosphoserine1090 relationship: transforms_into CCO:B0013192 ! NIPBL_HUMAN-Phosphoserine1096 relationship: transforms_into CCO:B0013193 ! NIPBL_HUMAN-Phosphoserine1150 relationship: transforms_into CCO:B0013194 ! NIPBL_HUMAN-Phosphoserine1152 relationship: transforms_into CCO:B0013195 ! NIPBL_HUMAN-Phosphoserine1154 relationship: transforms_into CCO:B0013196 ! NIPBL_HUMAN-Phosphotyrosine1159 relationship: transforms_into CCO:B0013197 ! NIPBL_HUMAN-Phosphoserine2658 relationship: transforms_into CCO:B0013198 ! NIPBL_HUMAN-Phosphothreonine2667 relationship: transforms_into CCO:B0013199 ! NIPBL_HUMAN-Phosphoserine2672 [Term] id: CCO:B0001909 name: RINT1_HUMAN def: "RAD50-interacting protein 1" [UniProtKB:Q6NUQ1] synonym: "HsRINT-1" EXACT [UniProtKB:Q6NUQ1] synonym: "Protein RINT-1" EXACT [UniProtKB:Q6NUQ1] synonym: "RAD50 interactor 1" EXACT [UniProtKB:Q6NUQ1] xref: EMBL:AAG42101.1 xref: EMBL:AAH07120.2 xref: EMBL:AAH68483.1 xref: EMBL:AAQ96849.1 xref: EMBL:AAQ96850.1 xref: EMBL:BAB13910.1 xref: UniProtKB:Q6NUQ1 xref: UniProtKB:Q75MG9 xref: UniProtKB:Q75MH0 xref: UniProtKB:Q96IW8 xref: UniProtKB:Q9H229 xref: UniProtKB:Q9HAD9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005491 ! RINT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007675 ! gfi1b-rint1 physical interaction relationship: participates_in CCO:I0007819 ! zw10_zwilch_1 physical interaction relationship: participates_in CCO:I0008498 ! rint1-bnip3l physical interaction relationship: participates_in CCO:I0008499 ! rint1-sptbn1 physical interaction relationship: participates_in CCO:I0008500 ! rint1-xpnpep1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000185 ! G2/M transition DNA damage checkpoint [Term] id: CCO:B0001910 name: Q6NVV2_HUMAN def: "Septin 7 pseudogene" [UniProtKB:Q6NVV2] xref: EMBL:AAH67889.1 xref: UniProtKB:Q6NVV2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006009 ! LOC441601_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001911 name: CDC73_HUMAN def: "Parafibromin" [UniProtKB:Q6P1J9] synonym: "Cell division cycle protein 73 homolog" EXACT [UniProtKB:Q6P1J9] synonym: "Hyperparathyroidism 2 protein" EXACT [UniProtKB:Q6P1J9] xref: EMBL:AAG45339.1 xref: EMBL:AAH07325.1 xref: EMBL:AAH14351.2 xref: EMBL:AAH65037.1 xref: EMBL:BAB15608.1 xref: EMBL:CAH71049.1 xref: EMBL:CAH71589.1 xref: EMBL:EAW91250.1 xref: UniProtKB:A6NLZ8 xref: UniProtKB:Q6P1J9 xref: UniProtKB:Q6PK51 xref: UniProtKB:Q96A07 xref: UniProtKB:Q9H245 xref: UniProtKB:Q9H5L7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004293 ! CDC73_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006890 ! cdc73-ctnnb1-4 physical interaction relationship: participates_in CCO:I0006999 ! cdc73-ctnnb1 physical interaction relationship: participates_in CCO:I0007000 ! cdc73-tcf4 physical interaction relationship: participates_in CCO:I0007414 ! cdc73-ctnnb1-1 physical interaction relationship: participates_in CCO:I0007415 ! cdc73-ctnnb1-2 physical interaction relationship: participates_in CCO:I0007416 ! cdc73-ctnnb1-5 physical interaction relationship: participates_in CCO:I0007790 ! cdc73-ctnnb1-3 physical interaction relationship: participates_in CCO:I0007791 ! cdc73-ctnnb1-6 physical interaction relationship: participates_in CCO:I0007792 ! cdc73-ctnnb1-7 physical interaction relationship: participates_in CCO:I0007917 ! parafibromin-ctnnb1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001912 name: PMF1_HUMAN def: "Polyamine-modulated factor 1" [UniProtKB:Q6P1K2] synonym: "PMF-1" EXACT [UniProtKB:Q6P1K2] xref: EMBL:AAD50080.1 xref: EMBL:AAD50081.1 xref: EMBL:AAH33656.2 xref: EMBL:AAH50735.1 xref: EMBL:AAH56417.1 xref: EMBL:AAH65031.1 xref: EMBL:CAH10730.1 xref: EMBL:CAI15536.1 xref: EMBL:CAI15539.1 xref: EMBL:CAI15540.1 xref: UniProtKB:Q5TCJ8 xref: UniProtKB:Q5TCJ9 xref: UniProtKB:Q5TCK3 xref: UniProtKB:Q69YZ9 xref: UniProtKB:Q6P1K2 xref: UniProtKB:Q6PHR4 xref: UniProtKB:Q86VJ6 xref: UniProtKB:Q8N4T6 xref: UniProtKB:Q9UBQ3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005343 ! PMF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction relationship: participates_in CCO:I0008149 ! pmf1-cops6 physical interaction relationship: participates_in CCO:I0008150 ! pmf1-git1 physical interaction relationship: participates_in CCO:I0008291 ! pmf1-med31 physical interaction relationship: participates_in CCO:I0008292 ! pmf1-crmp1 physical interaction relationship: participates_in CCO:I0008293 ! pmf1-ptn physical interaction relationship: participates_in CCO:I0008419 ! pmf1-gdf9 physical interaction relationship: participates_in CCO:I0008420 ! pmf1-kiaa1377 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001913 name: L2GL2_HUMAN def: "Lethal(2) giant larvae protein homolog 2" [UniProtKB:Q6P1M3] synonym: "HGL" EXACT [UniProtKB:Q6P1M3] xref: EMBL:AAH06503.1 xref: EMBL:AAH10879.1 xref: EMBL:AAH64994.1 xref: EMBL:CAA60780.1 xref: UniProtKB:Q14521 xref: UniProtKB:Q6P1M3 xref: UniProtKB:Q9BR62 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004967 ! LLGL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012657 ! L2GL2_HUMAN-Phosphoserine664 [Term] id: CCO:B0001914 name: BORA_HUMAN def: "Protein aurora borealis" [UniProtKB:Q6PGQ7] synonym: "HsBora" EXACT [UniProtKB:Q6PGQ7] xref: EMBL:AAH07119.1 xref: EMBL:AAH25367.2 xref: EMBL:AAH44213.1 xref: EMBL:AAH56876.2 xref: EMBL:BAB15426.1 xref: EMBL:CAH72712.2 xref: EMBL:CAH72713.1 xref: UniProtKB:Q5W0P3 xref: UniProtKB:Q5W0P4 xref: UniProtKB:Q6PGQ7 xref: UniProtKB:Q86YC6 xref: UniProtKB:Q96IW9 xref: UniProtKB:Q9H640 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004181 ! BORA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008387 ! fgfr3-flj22624 physical interaction relationship: participates_in CCO:I0008389 ! flj22624-fez1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001915 name: SYCE2_HUMAN def: "Synaptonemal complex central element protein 2" [UniProtKB:Q6PIF2] synonym: "Central element synaptonemal complex protein 1" EXACT [UniProtKB:Q6PIF2] xref: EMBL:AAH35819.1 xref: UniProtKB:Q6PIF2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005709 ! SYCE2_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000128 ! central element relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000119 ! meiotic prophase I [Term] id: CCO:B0001916 name: DCR1A_HUMAN def: "DNA cross-link repair 1A protein" [UniProtKB:Q6PJP8] synonym: "hSNM1" EXACT [UniProtKB:Q6PJP8] synonym: "hSNM1A" EXACT [UniProtKB:Q6PJP8] xref: EMBL:AAH13124.1 xref: EMBL:AAH62582.1 xref: EMBL:AAT09762.1 xref: EMBL:BAA07646.2 xref: EMBL:CAI12637.1 xref: UniProtKB:Q14701 xref: UniProtKB:Q6P5Y3 xref: UniProtKB:Q6PJP8 xref: UniProtKB:Q6PKL4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004446 ! DCLRE1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011451 ! DCR1A_HUMAN-Phosphoserine590 [Term] id: CCO:B0001918 name: SAS6_HUMAN def: "Spindle assembly abnormal protein 6 homolog" [UniProtKB:Q6UVJ0] synonym: "HsSAS-6" EXACT [UniProtKB:Q6UVJ0] xref: EMBL:AAQ57128.1 xref: EMBL:CAD38940.1 xref: EMBL:CAH72248.1 xref: UniProtKB:Q6UVJ0 xref: UniProtKB:Q8N3K0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005564 ! SASS6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000383 ! centrosome relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000300 ! centrosome duplication [Term] id: CCO:B0001922 name: TM11A_HUMAN def: "Transmembrane protease, serine 11A" [UniProtKB:Q6ZMR5] synonym: "Airway trypsin-like protease 1" EXACT [UniProtKB:Q6ZMR5] synonym: "EC 3.4.21.-" EXACT [UniProtKB:Q6ZMR5] synonym: "Epidermal type-II transmembrane serine protease" EXACT [UniProtKB:Q6ZMR5] synonym: "Esophageal cancer-susceptibility gene 1 protein" EXACT [UniProtKB:Q6ZMR5] xref: EMBL:AAD41463.1 xref: EMBL:AAI11797.1 xref: EMBL:AAS78642.1 xref: EMBL:BAD18660.1 xref: EMBL:CAD67985.1 xref: UniProtKB:Q2NKI9 xref: UniProtKB:Q6JE90 xref: UniProtKB:Q6ZMR5 xref: UniProtKB:Q7RTY4 xref: UniProtKB:Q86TK8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005793 ! TMPRSS11A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001923 name: Q6ZNA8_HUMAN def: "cDNA FLJ16262 fis, clone IMR322008651, highly similar to DNA REPAIR PROTEIN RAD51" [UniProtKB:Q6ZNA8] synonym: "cDNA FLJ78599" EXACT [UniProtKB:Q6ZNA8] synonym: "RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae), isoform CRA_e" EXACT [UniProtKB:Q6ZNA8] xref: EMBL:BAD18467.1 xref: EMBL:BAF84658.1 xref: EMBL:EAW92435.1 xref: UniProtKB:Q6ZNA8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005416 ! RAD51_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000279 ! damaged DNA binding relationship: has_function CCO:F0000282 ! double-stranded DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001707 ! DNA-dependent ATPase activity relationship: has_function CCO:F0003574 ! nucleoside-triphosphatase activity relationship: has_function CCO:F0005877 ! sequence-specific DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000120 ! condensed chromosome relationship: located_in CCO:C0000121 ! condensed nuclear chromosome relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0001924 name: Q6ZQZ4_HUMAN def: "cDNA FLJ46776 fis, clone TRACH3026650, highly similar to Actin cross-linking family protein 7" [UniProtKB:Q6ZQZ4] xref: EMBL:BAC87532.1 xref: UniProtKB:Q6ZQZ4 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001925 name: SEP14_HUMAN def: "Septin-14" [UniProtKB:Q6ZU15] xref: EMBL:BAC86412.1 xref: UniProtKB:Q6ZU15 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005583 ! SEPT14_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001926 name: Q6ZV00_HUMAN def: "cDNA FLJ43165 fis, clone FCBBF3002163, highly similar to Homo sapiens chromosome condensation-related SMC-associated protein 1" [UniProtKB:Q6ZV00] xref: EMBL:BAC86066.1 xref: UniProtKB:Q6ZV00 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0001633 ! binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001927 name: Q70WG0_HUMAN def: "T-cell-specific surface glycoprotein" [UniProtKB:Q70WG0] synonym: "CD28 antigen (Tp44), isoform CRA_b" EXACT [UniProtKB:Q70WG0] xref: EMBL:CAD57003.1 xref: EMBL:EAW70348.1 xref: UniProtKB:Q70WG0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004270 ! CD28_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000766 ! membrane relationship: participates_in CCO:P0000251 ! positive regulation of mitosis [Term] id: CCO:B0001929 name: MCM10_HUMAN def: "Protein MCM10 homolog" [UniProtKB:Q7L590] synonym: "HsMCM10" EXACT [UniProtKB:Q7L590] xref: EMBL:AAF69623.1 xref: EMBL:AAH04876.2 xref: EMBL:AAI01728.1 xref: EMBL:BAB18723.1 xref: EMBL:BAB70988.1 xref: EMBL:CAB66774.2 xref: EMBL:CAI12913.1 xref: EMBL:CAI16558.1 xref: UniProtKB:Q3MIR3 xref: UniProtKB:Q7L590 xref: UniProtKB:Q7LD55 xref: UniProtKB:Q96GX4 xref: UniProtKB:Q96NB6 xref: UniProtKB:Q9H0D7 xref: UniProtKB:Q9H3P9 xref: UniProtKB:Q9P177 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005036 ! MCM10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006083 ! mcm10-mcm2 direct interaction relationship: participates_in CCO:I0006085 ! mcm10-mcm6 direct interaction relationship: participates_in CCO:I0006092 ! mcm10-cdc7 direct interaction relationship: participates_in CCO:I0006095 ! mcm10-mcm3 direct interaction relationship: participates_in CCO:I0006098 ! mcm10-ccnd3 direct interaction relationship: participates_in CCO:I0006101 ! mcm10-hscdc5 direct interaction relationship: participates_in CCO:I0006104 ! mcm10-hscdc6 direct interaction relationship: participates_in CCO:I0006105 ! mcm10-ccnd1 direct interaction relationship: participates_in CCO:I0006106 ! mcm10-mcm7 direct interaction relationship: participates_in CCO:I0006119 ! mcm10-cdk6 direct interaction relationship: participates_in CCO:I0006145 ! cdkn2a-mcm10 direct interaction relationship: participates_in CCO:I0006161 ! cdkn1a-mcm10 direct interaction relationship: transforms_into CCO:B0012803 ! MCM10_HUMAN-Phosphothreonine85 relationship: transforms_into CCO:B0012804 ! MCM10_HUMAN-Phosphoserine93 [Term] id: CCO:B0001930 name: MAEA_HUMAN def: "Macrophage erythroblast attacher" [UniProtKB:Q7L5Y9] synonym: "Cell proliferation-inducing gene 5 protein" EXACT [UniProtKB:Q7L5Y9] synonym: "Erythroblast macrophage protein" EXACT [UniProtKB:Q7L5Y9] synonym: "HLC-10" EXACT [UniProtKB:Q7L5Y9] synonym: "Lung cancer-related protein 10" EXACT [UniProtKB:Q7L5Y9] xref: EMBL:AAC67543.1 xref: EMBL:AAH01225.2 xref: EMBL:AAH06470.1 xref: EMBL:AAO85220.1 xref: EMBL:AAP35603.1 xref: EMBL:AAP74806.1 xref: EMBL:BAA91499.1 xref: EMBL:BAB14072.1 xref: EMBL:BAB14113.1 xref: EMBL:BAC87375.1 xref: UniProtKB:O95285 xref: UniProtKB:Q5JB54 xref: UniProtKB:Q6ZRD6 xref: UniProtKB:Q7L5Y9 xref: UniProtKB:Q9BQ11 xref: UniProtKB:Q9H9V6 xref: UniProtKB:Q9H9Z4 xref: UniProtKB:Q9NW84 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005014 ! MAEA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001931 name: VASH1_HUMAN def: "Vasohibin-1" [UniProtKB:Q7L8A9] xref: EMBL:AAD44361.1 xref: EMBL:AAF02829.1 xref: EMBL:AAH09031.1 xref: EMBL:AAH51896.1 xref: EMBL:BAA82988.2 xref: EMBL:CAD89941.1 xref: UniProtKB:Q7L8A9 xref: UniProtKB:Q96H02 xref: UniProtKB:Q9UBF4 xref: UniProtKB:Q9Y629 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005893 ! VASH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000201 ! extracellular region relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001932 name: STRAD_HUMAN def: "STE20-related adapter protein" [UniProtKB:Q7RTN6] synonym: "Serologically defined breast cancer antigen NY-BR-96" EXACT [UniProtKB:Q7RTN6] synonym: "STRAD alpha" EXACT [UniProtKB:Q7RTN6] xref: EMBL:AAG48269.1 xref: EMBL:AAP42280.1 xref: EMBL:BAC11197.1 xref: EMBL:BAC11349.1 xref: EMBL:DAA01797.1 xref: UniProtKB:Q7RTN6 xref: UniProtKB:Q7Z4K9 xref: UniProtKB:Q8NC31 xref: UniProtKB:Q8NCF1 xref: UniProtKB:Q9H272 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005697 ! STRAD_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006454 ! lkb1-strad-2 physical interaction relationship: participates_in CCO:I0006455 ! lkb1-strad-4 physical interaction relationship: participates_in CCO:I0006456 ! stk11-strad-5 physical interaction relationship: participates_in CCO:I0006778 ! lkb1-strad-7 phosphorylation relationship: participates_in CCO:I0006779 ! lkb1-strad-8 phosphorylation relationship: participates_in CCO:I0006927 ! stk11-strad-6 colocalization relationship: participates_in CCO:I0007474 ! lkb1-strad-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014266 ! STRAD_HUMAN-Phosphothreonine329 relationship: transforms_into CCO:B0014267 ! STRAD_HUMAN-Phosphothreonine419 [Term] id: CCO:B0001933 name: CLAP1_HUMAN def: "CLIP-associating protein 1" [UniProtKB:Q7Z460] synonym: "Cytoplasmic linker-associated protein 1" EXACT [UniProtKB:Q7Z460] synonym: "hOrbit1" EXACT [UniProtKB:Q7Z460] synonym: "Multiple asters homolog 1" EXACT [UniProtKB:Q7Z460] xref: EMBL:AAH32563.1 xref: EMBL:AAI12941.1 xref: EMBL:AAQ15051.1 xref: EMBL:AAX88872.1 xref: EMBL:BAA31597.1 xref: EMBL:CAC35156.1 xref: EMBL:CAI46251.1 xref: UniProtKB:O75118 xref: UniProtKB:Q2KHQ9 xref: UniProtKB:Q5H9P0 xref: UniProtKB:Q7Z460 xref: UniProtKB:Q8N5B8 xref: UniProtKB:Q9BQT5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004366 ! CLASP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000152 ! exit from mitosis relationship: transforms_into CCO:B0011244 ! CLAP1_HUMAN-Phosphoserine545 relationship: transforms_into CCO:B0011245 ! CLAP1_HUMAN-Phosphoserine559 relationship: transforms_into CCO:B0011246 ! CLAP1_HUMAN-Phosphoserine568 relationship: transforms_into CCO:B0011247 ! CLAP1_HUMAN-Phosphoserine598 relationship: transforms_into CCO:B0011248 ! CLAP1_HUMAN-Phosphoserine600 relationship: transforms_into CCO:B0011249 ! CLAP1_HUMAN-Phosphoserine609 relationship: transforms_into CCO:B0011250 ! CLAP1_HUMAN-Phosphoserine1196 relationship: transforms_into CCO:B0011251 ! CLAP1_HUMAN-Phosphoserine1223 [Term] id: CCO:B0001935 name: Q7Z774_HUMAN def: "CCNE2 protein" [UniProtKB:Q7Z774] xref: EMBL:AAH07015.1 xref: UniProtKB:Q7Z774 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004252 ! CCNE2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001936 name: NPM2_HUMAN def: "Nucleoplasmin-2" [UniProtKB:Q86SE8] xref: EMBL:AAP33134.1 xref: EMBL:AAP33135.1 xref: UniProtKB:Q86SE8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005211 ! NPM2_human relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0005669 ! histone binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000116 ! cytoplasmic chromatin relationship: located_in CCO:C0000117 ! nuclear chromatin relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis relationship: participates_in CCO:P0000249 ! positive regulation of meiosis [Term] id: CCO:B0001938 name: PB1_HUMAN def: "Protein polybromo-1" [UniProtKB:Q86U86] synonym: "BAF180" EXACT [UniProtKB:Q86U86] synonym: "BRG1-associated factor 180" EXACT [UniProtKB:Q86U86] synonym: "hPB1" EXACT [UniProtKB:Q86U86] synonym: "Polybromo-1D" EXACT [UniProtKB:Q86U86] xref: EMBL:AAG34760.1 xref: EMBL:AAG48933.1 xref: EMBL:AAG48939.1 xref: EMBL:AAG48940.1 xref: EMBL:AAG48941.1 xref: EMBL:AAP34197.1 xref: UniProtKB:Q86U86 xref: UniProtKB:Q9H2T3 xref: UniProtKB:Q9H2T4 xref: UniProtKB:Q9H2T5 xref: UniProtKB:Q9H301 xref: UniProtKB:Q9H314 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005272 ! PBRM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006205 ! smarca4-pb1-arid2-1 physical interaction relationship: participates_in CCO:I0006322 ! pb1-arid2-4 physical interaction relationship: participates_in CCO:I0006729 ! pb1-arid2-2 physical interaction relationship: participates_in CCO:I0006977 ! smarca4-pb1-arid2-2 physical interaction relationship: participates_in CCO:I0007259 ! arid2-pb1-1 physical interaction relationship: participates_in CCO:I0007356 ! pb1-arid2-3 physical interaction relationship: participates_in CCO:I0007569 ! brg1-baf200-2 physical interaction relationship: participates_in CCO:I0007961 ! pb1-arid2-1 physical interaction relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013425 ! PB1_HUMAN-Phosphoserine39 relationship: transforms_into CCO:B0013426 ! PB1_HUMAN-Phosphotyrosine54 relationship: transforms_into CCO:B0013427 ! PB1_HUMAN-Phosphothreonine301 relationship: transforms_into CCO:B0013428 ! PB1_HUMAN-Phosphoserine636 relationship: transforms_into CCO:B0013429 ! PB1_HUMAN-Phosphoserine948 relationship: transforms_into CCO:B0013430 ! PB1_HUMAN-Phosphoserine1453 [Term] id: CCO:B0001939 name: TLK2_HUMAN def: "Serine/threonine-protein kinase tousled-like 2" [UniProtKB:Q86UE8] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q86UE8] synonym: "PKU-alpha" EXACT [UniProtKB:Q86UE8] synonym: "Tousled-like kinase 2" EXACT [UniProtKB:Q86UE8] xref: EMBL:AAF03095.1 xref: EMBL:AAH44925.2 xref: EMBL:BAA20561.1 xref: UniProtKB:Q86UE8 xref: UniProtKB:Q9UKI7 xref: UniProtKB:Q9Y4F7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005792 ! TLK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014413 ! TLK2_HUMAN-Phosphoserine99 relationship: transforms_into CCO:B0014414 ! TLK2_HUMAN-Phosphoserine750 [Term] id: CCO:B0001940 name: CUZD1_HUMAN def: "CUB and zona pellucida-like domain-containing protein 1 precursor" [UniProtKB:Q86UP6] synonym: "CUB and ZP domain-containing protein 1" EXACT [UniProtKB:Q86UP6] synonym: "Transmembrane protein UO-44" EXACT [UniProtKB:Q86UP6] xref: EMBL:AAG23215.1 xref: EMBL:AAP15458.1 xref: EMBL:AAP15459.1 xref: EMBL:AAP15460.1 xref: EMBL:AAP15461.1 xref: EMBL:AAQ88920.1 xref: EMBL:CAD98079.2 xref: EMBL:CAD98080.2 xref: EMBL:CAH70003.1 xref: EMBL:CAH70004.1 xref: EMBL:CAH70006.1 xref: UniProtKB:Q7Z660 xref: UniProtKB:Q7Z661 xref: UniProtKB:Q86SG1 xref: UniProtKB:Q86UP5 xref: UniProtKB:Q86UP6 xref: UniProtKB:Q9HAR7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004429 ! CUZD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001941 name: NIPA_HUMAN def: "Nuclear-interacting partner of ALK" [UniProtKB:Q86WB0] synonym: "hNIPA" EXACT [UniProtKB:Q86WB0] synonym: "Nuclear-interacting partner of anaplastic lymphoma kinase" EXACT [UniProtKB:Q86WB0] synonym: "Zinc finger C3HC-type protein 1" EXACT [UniProtKB:Q86WB0] xref: EMBL:AAF36136.1 xref: EMBL:AAH11551.1 xref: EMBL:AAH28917.1 xref: EMBL:AAS07546.1 xref: EMBL:AAS07547.1 xref: EMBL:BAA91619.1 xref: EMBL:BAB14024.1 xref: EMBL:CAD61161.1 xref: UniProtKB:A6NH66 xref: UniProtKB:Q75MF3 xref: UniProtKB:Q75MF4 xref: UniProtKB:Q86WB0 xref: UniProtKB:Q8N330 xref: UniProtKB:Q96F75 xref: UniProtKB:Q9HA34 xref: UniProtKB:Q9NVX4 xref: UniProtKB:Q9P0R0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005195 ! ZC3HC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013174 ! NIPA_HUMAN-Phosphoserine24 relationship: transforms_into CCO:B0013175 ! NIPA_HUMAN-Phosphothreonine28 relationship: transforms_into CCO:B0013176 ! NIPA_HUMAN-Phosphoserine62 relationship: transforms_into CCO:B0013177 ! NIPA_HUMAN-Phosphoserine321 relationship: transforms_into CCO:B0013178 ! NIPA_HUMAN-Phosphoserine354 relationship: transforms_into CCO:B0013179 ! NIPA_HUMAN-Phosphoserine370 relationship: transforms_into CCO:B0036019 ! NIPA_HUMAN-Phosphothreonine84 [Term] id: CCO:B0001942 name: HORM1_HUMAN def: "HORMA domain-containing protein 1" [UniProtKB:Q86X24] synonym: "Cancer/testis antigen 46" EXACT [UniProtKB:Q86X24] synonym: "CT46" EXACT [UniProtKB:Q86X24] synonym: "Newborn ovary HORMA protein" EXACT [UniProtKB:Q86X24] xref: EMBL:AAH33014.1 xref: EMBL:AAH47406.1 xref: EMBL:AAT45740.1 xref: EMBL:CAB66689.1 xref: EMBL:CAG38536.1 xref: EMBL:CAI13652.1 xref: EMBL:CAI13653.1 xref: EMBL:CAI13654.1 xref: EMBL:CAI13655.1 xref: EMBL:CAI13656.1 xref: UniProtKB:Q4G114 xref: UniProtKB:Q5T5I3 xref: UniProtKB:Q5T5I4 xref: UniProtKB:Q5T5I5 xref: UniProtKB:Q6FIC1 xref: UniProtKB:Q86X24 xref: UniProtKB:Q9H0K8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004824 ! HORMAD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001943 name: CNDG2_HUMAN def: "Condensin-2 complex subunit G2" [UniProtKB:Q86XI2] synonym: "CAP-G2" EXACT [UniProtKB:Q86XI2] synonym: "Chromosome-associated protein G2" EXACT [UniProtKB:Q86XI2] synonym: "hCAP-G2" EXACT [UniProtKB:Q86XI2] synonym: "Leucine zipper protein 5" EXACT [UniProtKB:Q86XI2] synonym: "Non-SMC condensin II complex subunit G2" EXACT [UniProtKB:Q86XI2] xref: EMBL:AAH05878.2 xref: EMBL:AAH20560.1 xref: EMBL:AAH43404.1 xref: EMBL:BAB14219.1 xref: EMBL:BAB14534.1 xref: EMBL:CAD97854.1 xref: UniProtKB:Q7Z3J9 xref: UniProtKB:Q86XI2 xref: UniProtKB:Q8WUG8 xref: UniProtKB:Q9BRX6 xref: UniProtKB:Q9H8S2 xref: UniProtKB:Q9H9K6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004380 ! NCAPG2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: transforms_into CCO:B0011317 ! CNDG2_HUMAN-Phosphothreonine805 relationship: transforms_into CCO:B0011318 ! CNDG2_HUMAN-Phosphothreonine1119 [Term] id: CCO:B0001944 name: GA2L3_HUMAN def: "GAS2-like protein 3" [UniProtKB:Q86XJ1] synonym: "Growth arrest-specific protein 2-like 3" EXACT [UniProtKB:Q86XJ1] xref: EMBL:AAH43366.1 xref: UniProtKB:Q86XJ1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004673 ! GAS2L3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001946 name: SIAH1_HUMAN def: "E3 ubiquitin-protein ligase SIAH1" [UniProtKB:Q8IUQ4] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q8IUQ4] synonym: "Seven in absentia homolog 1" EXACT [UniProtKB:Q8IUQ4] synonym: "Siah-1" EXACT [UniProtKB:Q8IUQ4] synonym: "Siah-1a" EXACT [UniProtKB:Q8IUQ4] xref: EMBL:AAC12950.1 xref: EMBL:AAC51907.1 xref: EMBL:AAH35562.1 xref: EMBL:AAH42550.1 xref: EMBL:AAH44920.1 xref: EMBL:ABK15529.1 xref: EMBL:CAC35542.1 xref: EMBL:CAE46191.1 xref: UniProtKB:A0FKF3 xref: UniProtKB:O43269 xref: UniProtKB:Q49A58 xref: UniProtKB:Q8IUQ4 xref: UniProtKB:Q92880 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005612 ! SIAH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005805 ! aff4-siah1 physical interaction relationship: participates_in CCO:I0005945 ! khdrbs3-siah1 physical interaction relationship: participates_in CCO:I0007616 ! atn1-siah1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001947 name: EGFL6_HUMAN def: "EGF-like domain-containing protein 6 precursor" [UniProtKB:Q8IUX8] synonym: "MAM and EGF domains-containing gene protein" EXACT [UniProtKB:Q8IUX8] synonym: "Multiple EGF-like domain protein 6" EXACT [UniProtKB:Q8IUX8] synonym: "Multiple epidermal growth factor-like domain protein 6" EXACT [UniProtKB:Q8IUX8] xref: EMBL:AAF27812.1 xref: EMBL:AAG22483.1 xref: EMBL:AAH38587.1 xref: EMBL:AAQ88699.1 xref: EMBL:BAC11477.1 xref: EMBL:CAB56014.2 xref: EMBL:CAB92132.1 xref: UniProtKB:Q6UXJ1 xref: UniProtKB:Q8IUX8 xref: UniProtKB:Q8NBV0 xref: UniProtKB:Q8WYG3 xref: UniProtKB:Q9NY67 xref: UniProtKB:Q9NZL7 xref: UniProtKB:Q9UFK6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004550 ! EGFL6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008225 ! egfl6-sh3gl3 physical interaction relationship: participates_in CCO:I0008385 ! egfl6-sh3gl2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001949 name: PARC_HUMAN def: "p53-associated parkin-like cytoplasmic protein" [UniProtKB:Q8IWT3] synonym: "UbcH7-associated protein 1" EXACT [UniProtKB:Q8IWT3] xref: EMBL:AAH02879.2 xref: EMBL:AAN61516.1 xref: EMBL:BAA31683.3 xref: EMBL:BAC85207.1 xref: EMBL:BAC86090.1 xref: EMBL:CAC85756.1 xref: EMBL:CAH18328.1 xref: EMBL:CAH18696.1 xref: UniProtKB:O75188 xref: UniProtKB:Q68CP2 xref: UniProtKB:Q68D92 xref: UniProtKB:Q8IWT3 xref: UniProtKB:Q8N3W9 xref: UniProtKB:Q9BU56 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005265 ! PARC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006475 ! kiaa1206-parc physical interaction relationship: participates_in CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition [Term] id: CCO:B0001950 name: CCAR1_HUMAN def: "Cell division cycle and apoptosis regulator protein 1" [UniProtKB:Q8IX12] synonym: "CARP-1" EXACT [UniProtKB:Q8IX12] synonym: "Cell cycle and apoptosis regulatory protein 1" EXACT [UniProtKB:Q8IX12] synonym: "Death inducer with SAP domain" EXACT [UniProtKB:Q8IX12] xref: EMBL:AAH26036.1 xref: EMBL:AAI08683.1 xref: EMBL:AAO17319.1 xref: EMBL:AAP82002.1 xref: EMBL:BAA91354.1 xref: EMBL:BAA91700.1 xref: EMBL:BAA91847.1 xref: EMBL:BAB14574.1 xref: EMBL:CAH70221.1 xref: EMBL:CAH73835.1 xref: UniProtKB:Q32NE3 xref: UniProtKB:Q5VUP6 xref: UniProtKB:Q6PIZ0 xref: UniProtKB:Q6X935 xref: UniProtKB:Q8IX12 xref: UniProtKB:Q9H8N4 xref: UniProtKB:Q9NVA7 xref: UniProtKB:Q9NVQ0 xref: UniProtKB:Q9NWM6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004236 ! CCAR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006365 ! ikbkg-q8ix12 physical interaction relationship: participates_in CCO:I0006505 ! q9btt4-q71f56-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0010974 ! CCAR1_HUMAN-Phosphoserine214 relationship: transforms_into CCO:B0010975 ! CCAR1_HUMAN-Phosphoserine329 relationship: transforms_into CCO:B0010976 ! CCAR1_HUMAN-Phosphoserine333 relationship: transforms_into CCO:B0010977 ! CCAR1_HUMAN-Phosphoserine339 relationship: transforms_into CCO:B0010978 ! CCAR1_HUMAN-Phosphoserine343 relationship: transforms_into CCO:B0010979 ! CCAR1_HUMAN-Phosphoserine1149 [Term] id: CCO:B0001951 name: SIRT2_HUMAN def: "NAD-dependent deacetylase sirtuin-2" [UniProtKB:Q8IXJ6] synonym: "EC 3.5.1.-" EXACT [UniProtKB:Q8IXJ6] synonym: "SIR2-like" EXACT [UniProtKB:Q8IXJ6] synonym: "SIR2-like protein 2" EXACT [UniProtKB:Q8IXJ6] xref: EMBL:AAD20046.1 xref: EMBL:AAD40850.2 xref: EMBL:AAD45971.1 xref: EMBL:AAF67015.1 xref: EMBL:AAH03012.1 xref: EMBL:AAH03547.1 xref: EMBL:AAK51133.1 xref: EMBL:CAD43717.1 xref: UniProtKB:O95889 xref: UniProtKB:Q8IXJ6 xref: UniProtKB:Q924Y7 xref: UniProtKB:Q9P0G8 xref: UniProtKB:Q9UNT0 xref: UniProtKB:Q9Y6E9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005617 ! SIRT2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006513 ! sirt2-hdac6-2 colocalization relationship: participates_in CCO:I0006708 ! sirt2-hdac6-1 physical interaction relationship: participates_in CCO:I0006958 ! sirt2-pcaf-myod1-2 physical interaction relationship: participates_in CCO:I0007534 ! sirt2-pcaf-1 physical interaction relationship: participates_in CCO:I0007535 ! sirt2-pcaf-2 physical interaction relationship: participates_in CCO:I0007536 ! sirt2-pcaf-myod1-1 physical interaction relationship: participates_in CCO:I0007847 ! sirt2-pcaf-3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis relationship: transforms_into CCO:B0041195 ! SIRT2_HUMAN-Phosphoserine25 relationship: transforms_into CCO:B0041196 ! SIRT2_HUMAN-Phosphoserine27 [Term] id: CCO:B0001952 name: RM41_HUMAN def: "39S ribosomal protein L41, mitochondrial precursor" [UniProtKB:Q8IXM3] synonym: "39S ribosomal protein L27 homolog" EXACT [UniProtKB:Q8IXM3] synonym: "Bcl-2-interacting mitochondrial ribosomal protein L41" EXACT [UniProtKB:Q8IXM3] synonym: "Cell proliferation-inducing gene 3 protein" EXACT [UniProtKB:Q8IXM3] synonym: "L41mt" EXACT [UniProtKB:Q8IXM3] synonym: "MRP-L27 homolog" EXACT [UniProtKB:Q8IXM3] synonym: "MRP-L41" EXACT [UniProtKB:Q8IXM3] xref: EMBL:AAH40035.1 xref: EMBL:AAP69986.1 xref: EMBL:BAB54952.1 xref: EMBL:CAI14583.1 xref: UniProtKB:Q8IXM3 xref: UniProtKB:Q96Q49 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005515 ! MRPL41_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001954 name: XRN1_HUMAN def: "5'-3' exoribonuclease 1" [UniProtKB:Q8IZH2] synonym: "EC 3.1.11.-" EXACT [UniProtKB:Q8IZH2] synonym: "Strand-exchange protein 1 homolog" EXACT [UniProtKB:Q8IZH2] xref: EMBL:AAH39314.1 xref: EMBL:AAH48104.1 xref: EMBL:AAN11306.1 xref: EMBL:BAC04718.1 xref: EMBL:CAB63749.1 xref: EMBL:CAE45950.1 xref: EMBL:CAH10490.1 xref: EMBL:CAH18332.1 xref: UniProtKB:Q4G0S3 xref: UniProtKB:Q68D88 xref: UniProtKB:Q6AI24 xref: UniProtKB:Q6MZS8 xref: UniProtKB:Q86WS7 xref: UniProtKB:Q8IZH2 xref: UniProtKB:Q8N8U4 xref: UniProtKB:Q9UF39 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005947 ! XRN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006911 ! dcp1a-rcd8-xrn1 colocalization relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0014721 ! XRN1_HUMAN-Phosphoserine1173 relationship: transforms_into CCO:B0014722 ! XRN1_HUMAN-Phosphoserine1176 [Term] id: CCO:B0001955 name: CCRK_HUMAN def: "Cell cycle-related kinase" [UniProtKB:Q8IZL9] synonym: "CAK-kinase p42" EXACT [UniProtKB:Q8IZL9] synonym: "CDK-activating kinase p42" EXACT [UniProtKB:Q8IZL9] synonym: "Cyclin-dependent protein kinase H" EXACT [UniProtKB:Q8IZL9] synonym: "Cyclin-kinase-activating kinase p42" EXACT [UniProtKB:Q8IZL9] synonym: "EC 2.7.11.22" EXACT [UniProtKB:Q8IZL9] xref: EMBL:AAH02655.1 xref: EMBL:AAN28684.1 xref: EMBL:AAW82349.1 xref: EMBL:CAH72843.1 xref: UniProtKB:Q5EDC4 xref: UniProtKB:Q5VYW1 xref: UniProtKB:Q8IZL9 xref: UniProtKB:Q9BUF4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004266 ! CCRK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001956 name: ASPM_HUMAN def: "Abnormal spindle-like microcephaly-associated protein" [UniProtKB:Q8IZT6] synonym: "Abnormal spindle protein homolog" EXACT [UniProtKB:Q8IZT6] synonym: "Asp homolog" EXACT [UniProtKB:Q8IZT6] xref: EMBL:AAH15396.1 xref: EMBL:AAH34607.1 xref: EMBL:AAM44119.1 xref: EMBL:AAM44120.1 xref: EMBL:AAM44121.1 xref: EMBL:AAM44122.1 xref: EMBL:AAM48745.1 xref: EMBL:AAN40011.1 xref: EMBL:AAR12641.1 xref: EMBL:BAA91660.1 xref: EMBL:BAA91676.1 xref: UniProtKB:Q86UX4 xref: UniProtKB:Q8IUL2 xref: UniProtKB:Q8IZJ7 xref: UniProtKB:Q8IZJ8 xref: UniProtKB:Q8IZJ9 xref: UniProtKB:Q8IZT6 xref: UniProtKB:Q8N4D1 xref: UniProtKB:Q9NVS1 xref: UniProtKB:Q9NVT6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004108 ! ASPM_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0010607 ! ASPM_HUMAN-Phosphoserine14 relationship: transforms_into CCO:B0010608 ! ASPM_HUMAN-Phosphoserine35 relationship: transforms_into CCO:B0010609 ! ASPM_HUMAN-Phosphoserine222 relationship: transforms_into CCO:B0010610 ! ASPM_HUMAN-Phosphoserine225 relationship: transforms_into CCO:B0010611 ! ASPM_HUMAN-Phosphoserine263 relationship: transforms_into CCO:B0010612 ! ASPM_HUMAN-Phosphoserine267 relationship: transforms_into CCO:B0010613 ! ASPM_HUMAN-Phosphoserine270 relationship: transforms_into CCO:B0010614 ! ASPM_HUMAN-Phosphoserine280 relationship: transforms_into CCO:B0010615 ! ASPM_HUMAN-Phosphoserine283 relationship: transforms_into CCO:B0010616 ! ASPM_HUMAN-Phosphoserine348 relationship: transforms_into CCO:B0010617 ! ASPM_HUMAN-Phosphoserine367 relationship: transforms_into CCO:B0010618 ! ASPM_HUMAN-Phosphoserine370 relationship: transforms_into CCO:B0010619 ! ASPM_HUMAN-Phosphoserine392 relationship: transforms_into CCO:B0010620 ! ASPM_HUMAN-Phosphoserine425 relationship: transforms_into CCO:B0010621 ! ASPM_HUMAN-Phosphoserine463 relationship: transforms_into CCO:B0010622 ! ASPM_HUMAN-Phosphothreonine563 relationship: transforms_into CCO:B0010623 ! ASPM_HUMAN-Phosphoserine605 relationship: transforms_into CCO:B0010624 ! ASPM_HUMAN-Phosphothreonine647 relationship: transforms_into CCO:B0010625 ! ASPM_HUMAN-Phosphoserine1103 relationship: transforms_into CCO:B0010626 ! ASPM_HUMAN-Phosphoserine2429 relationship: transforms_into CCO:B0010627 ! ASPM_HUMAN-Phosphothreonine3435 [Term] id: CCO:B0001957 name: SYCP3_HUMAN def: "Synaptonemal complex protein 3" [UniProtKB:Q8IZU3] synonym: "SCP-3" EXACT [UniProtKB:Q8IZU3] xref: EMBL:AAH62662.1 xref: EMBL:AAN06611.1 xref: EMBL:AAP47204.1 xref: UniProtKB:Q8IZU3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005712 ! SYCP3_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000132 ! male meiosis I [Term] id: CCO:B0001958 name: Q8IZX3_HUMAN def: "MAD2 mitotic arrest deficient-like 1 variant" [UniProtKB:Q8IZX3] synonym: "MAD2 mitotic arrest deficient-like 1 (Yeast), isoform CRA_b" EXACT [UniProtKB:Q8IZX3] xref: EMBL:AAN74648.1 xref: EMBL:EAX05271.1 xref: UniProtKB:Q8IZX3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005048 ! MAD2L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001959 name: TAF1L_HUMAN def: "Transcription initiation factor TFIID 210 kDa subunit" [UniProtKB:Q8IZX4] synonym: "TAF(II)210" EXACT [UniProtKB:Q8IZX4] synonym: "TBP-associated factor 1-like" EXACT [UniProtKB:Q8IZX4] synonym: "TBP-associated factor 210 kDa" EXACT [UniProtKB:Q8IZX4] xref: EMBL:AAN40840.1 xref: UniProtKB:Q0VG57 xref: UniProtKB:Q8IZX4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005725 ! TAF1L_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000813 ! histone acetyltransferase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003205 ! transcription activator activity relationship: has_function CCO:F0003518 ! TATA-binding protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000274 ! transcription factor TFIID complex relationship: participates_in CCO:I0007734 ! taf1l-tbp-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000131 ! male meiosis [Term] id: CCO:B0001960 name: SYCE1_HUMAN def: "Synaptonemal complex central element protein 1" [UniProtKB:Q8N0S2] synonym: "Cancer/testis antigen 76" EXACT [UniProtKB:Q8N0S2] synonym: "CT76" EXACT [UniProtKB:Q8N0S2] xref: EMBL:AAH34821.1 xref: EMBL:AAK14796.1 xref: EMBL:AAK14797.1 xref: EMBL:AAK21976.1 xref: EMBL:CAH70048.1 xref: UniProtKB:Q8N0S2 xref: UniProtKB:Q9BWU3 xref: UniProtKB:Q9BWU4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005708 ! SYCE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000119 ! meiotic prophase I [Term] id: CCO:B0001961 name: CNTRB_HUMAN def: "Centrobin" [UniProtKB:Q8N137] synonym: "Centrosomal BRCA2-interacting protein" EXACT [UniProtKB:Q8N137] synonym: "LYST-interacting protein 8" EXACT [UniProtKB:Q8N137] xref: EMBL:AAG49447.1 xref: EMBL:AAH14055.3 xref: EMBL:AAH21134.1 xref: EMBL:AAL56068.2 xref: EMBL:AAO22135.1 xref: EMBL:AAO22136.1 xref: EMBL:BAC11241.1 xref: EMBL:CAD38763.1 xref: EMBL:CAH10698.1 xref: UniProtKB:Q331K3 xref: UniProtKB:Q69YV7 xref: UniProtKB:Q8N137 xref: UniProtKB:Q8NCB8 xref: UniProtKB:Q8WXV3 xref: UniProtKB:Q96CQ7 xref: UniProtKB:Q9C060 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004382 ! CNTROB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007613 ! aptx-cntrob physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000109 ! centriole replication relationship: participates_in CCO:P0000301 ! centrosome separation relationship: transforms_into CCO:B0011319 ! CNTRB_HUMAN-Phosphoserine781 [Term] id: CCO:B0001962 name: STAG2_HUMAN def: "Cohesin subunit SA-2" [UniProtKB:Q8N3U4] synonym: "SCC3 homolog 2" EXACT [UniProtKB:Q8N3U4] synonym: "Stromal antigen 2" EXACT [UniProtKB:Q8N3U4] xref: EMBL:AAH01765.2 xref: EMBL:CAA99732.1 xref: EMBL:CAD38591.1 xref: EMBL:CAI40990.1 xref: UniProtKB:O00540 xref: UniProtKB:Q5JTI6 xref: UniProtKB:Q8N3U4 xref: UniProtKB:Q9H1N8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005684 ! STAG2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006783 ! rad21-stag2 physical interaction relationship: participates_in CCO:I0007036 ! wapl-cspg6 physical interaction relationship: participates_in CCO:I0007037 ! wapl-cspg6-3 physical interaction relationship: participates_in CCO:I0007039 ! wapl-cspg6-1 physical interaction relationship: participates_in CCO:I0007040 ! wapl-cspg6-2 physical interaction relationship: participates_in CCO:I0007711 ! wapl-cspg6-4 physical interaction relationship: participates_in CCO:I0007712 ! wapl-cspg6-5 physical interaction relationship: participates_in CCO:I0007714 ! wapl-cspg6-7 physical interaction relationship: participates_in CCO:I0007715 ! wapl-cspg6-9 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0014241 ! STAG2_HUMAN-Phosphoserine1061 relationship: transforms_into CCO:B0014242 ! STAG2_HUMAN-Phosphothreonine1160 [Term] id: CCO:B0001963 name: KIF2B_HUMAN def: "Kinesin-like protein KIF2B" [UniProtKB:Q8N4N8] xref: EMBL:AAH33802.1 xref: EMBL:AAK20830.2 xref: EMBL:BAB71406.1 xref: UniProtKB:Q8N4N8 xref: UniProtKB:Q96MA2 xref: UniProtKB:Q9BXG6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004946 ! KIF2B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006848 ! stau-loc84643-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001964 name: AF1L2_HUMAN def: "Actin filament-associated protein 1-like 2" [UniProtKB:Q8N4X5] xref: EMBL:AAH24314.1 xref: EMBL:AAH33212.1 xref: EMBL:BAB55135.1 xref: EMBL:BAB67807.1 xref: EMBL:CAI14967.1 xref: EMBL:CAI14968.1 xref: EMBL:CAI40128.1 xref: EMBL:CAI40129.1 xref: UniProtKB:Q8N4X5 xref: UniProtKB:Q8TB54 xref: UniProtKB:Q96PX4 xref: UniProtKB:Q96SY5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004034 ! AFAP1L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000138 ! regulation of mitotic cell cycle relationship: transforms_into CCO:B0010467 ! AF1L2_HUMAN-Phosphothreonine345 relationship: transforms_into CCO:B0010468 ! AF1L2_HUMAN-Phosphotyrosine413 relationship: transforms_into CCO:B0010469 ! AF1L2_HUMAN-Phosphotyrosine668 relationship: transforms_into CCO:B0010470 ! AF1L2_HUMAN-Phosphothreonine669 relationship: transforms_into CCO:B0031289 ! AF1L2_HUMAN-Phosphotyrosine56 [Term] id: CCO:B0001966 name: CD2A2_HUMAN def: "Cyclin-dependent kinase inhibitor 2A, isoform 4" [UniProtKB:Q8N726] synonym: "p14ARF" EXACT [UniProtKB:Q8N726] synonym: "p19ARF" EXACT [UniProtKB:Q8N726] xref: EMBL:AAA82236.1 xref: EMBL:AAB01737.1 xref: EMBL:AAC60649.1 xref: EMBL:AAM77919.1 xref: EMBL:AAP35666.1 xref: EMBL:CAH70601.1 xref: UniProtKB:Q13195 xref: UniProtKB:Q13399 xref: UniProtKB:Q16360 xref: UniProtKB:Q7KZR9 xref: UniProtKB:Q8N726 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004271 ! CDKN2A_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0007256 ! huew1-cdkn2a-1 physical interaction relationship: participates_in CCO:I0007257 ! cdkn2a-huew1-3 physical interaction relationship: participates_in CCO:I0007426 ! cdkn2a-huew1-2 physical interaction relationship: participates_in CCO:I0007874 ! cdkn2a-huew1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001967 name: HORM2_HUMAN def: "HORMA domain-containing protein 2" [UniProtKB:Q8N7B1] xref: EMBL:AAH30013.1 xref: EMBL:BAC05388.1 xref: EMBL:CAG30227.1 xref: UniProtKB:Q8N7B1 xref: UniProtKB:Q8NHR2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004825 ! HORMAD2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001969 name: Q8N855_HUMAN def: "cDNA FLJ39978 fis, clone SPLEN2029380" [UniProtKB:Q8N855] xref: EMBL:BAC04995.1 xref: UniProtKB:Q8N855 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001971 name: BANP_HUMAN def: "Protein BANP" [UniProtKB:Q8N9N5] synonym: "Btg3-associated nuclear protein" EXACT [UniProtKB:Q8N9N5] synonym: "Scaffold/matrix-associated region-1-binding protein" EXACT [UniProtKB:Q8N9N5] xref: EMBL:AAH09424.1 xref: EMBL:BAA91244.1 xref: EMBL:BAC04296.1 xref: UniProtKB:Q8N9N5 xref: UniProtKB:Q96GJ7 xref: UniProtKB:Q9NWY1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004136 ! BANP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001972 name: BOLL_HUMAN def: "Protein boule-like" [UniProtKB:Q8N9W6] xref: EMBL:AAH33674.1 xref: EMBL:AAK58689.1 xref: EMBL:BAB71664.1 xref: EMBL:BAC04171.1 xref: UniProtKB:Q8N9W6 xref: UniProtKB:Q969U3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004180 ! BOLL_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000308 ! RNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001952 ! translation activator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0007300 ! daz1-boll-1 physical interaction relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0001973 name: SPC24_HUMAN def: "Kinetochore protein Spc24" [UniProtKB:Q8NBT2] synonym: "hSpc24" EXACT [UniProtKB:Q8NBT2] xref: EMBL:AAI05038.1 xref: EMBL:AAI05040.1 xref: EMBL:AAR88651.1 xref: EMBL:BAC11523.1 xref: UniProtKB:Q8NBT2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006370 ! SPC24_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0006224 ! spbc24-spbc25-4 physical interaction relationship: participates_in CCO:I0006764 ! kntc2-spbc24-3 physical interaction relationship: participates_in CCO:I0007169 ! kntc2-spbc24-4 physical interaction relationship: participates_in CCO:I0007301 ! kntc2-spbc24-1 physical interaction relationship: participates_in CCO:I0007302 ! spbc24-spbc25-3 physical interaction relationship: participates_in CCO:I0007464 ! spbc24-spbc25-1 physical interaction relationship: participates_in CCO:I0007465 ! spbc24-spbc25-2 physical interaction relationship: participates_in CCO:I0007816 ! spbc24-spbc25-5 colocalization relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction relationship: participates_in CCO:I0007932 ! kntc2-spbc24-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014174 ! SPC24_HUMAN-Phosphothreonine130 [Term] id: CCO:B0001975 name: PAPD5_HUMAN def: "PAP-associated domain-containing protein 5" [UniProtKB:Q8NDF8] synonym: "EC 2.7.7.-" EXACT [UniProtKB:Q8NDF8] synonym: "Topoisomerase-related function protein 4-2" EXACT [UniProtKB:Q8NDF8] synonym: "TRF4-2" EXACT [UniProtKB:Q8NDF8] xref: EMBL:AAD45199.1 xref: EMBL:BAA91518.1 xref: EMBL:CAD38778.1 xref: UniProtKB:Q8NDF8 xref: UniProtKB:Q9NW67 xref: UniProtKB:Q9Y6C0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005258 ! PAPD5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0001976 name: RCBT1_HUMAN def: "RCC1 and BTB domain-containing protein 1" [UniProtKB:Q8NDN9] synonym: "Chronic lymphocytic leukemia deletion region gene 7 protein" EXACT [UniProtKB:Q8NDN9] synonym: "CLL deletion region gene 7 protein" EXACT [UniProtKB:Q8NDN9] synonym: "Regulator of chromosome condensation and BTB domain-containing protein 1" EXACT [UniProtKB:Q8NDN9] xref: EMBL:AAK38372.1 xref: EMBL:BAC04833.1 xref: EMBL:CAC40027.1 xref: EMBL:CAD38683.1 xref: EMBL:CAH71047.1 xref: UniProtKB:Q8NDN9 xref: UniProtKB:Q969U9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005455 ! RCBTB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001977 name: SMC1B_HUMAN def: "Structural maintenance of chromosomes protein 1B" [UniProtKB:Q8NDV3] synonym: "SMC1beta protein" EXACT [UniProtKB:Q8NDV3] xref: EMBL:CAD43404.2 xref: EMBL:CAI17945.1 xref: EMBL:CAI18928.1 xref: UniProtKB:Q5TIC3 xref: UniProtKB:Q8NDV3 xref: UniProtKB:Q9Y3G5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005626 ! SMC1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0014074 ! SMC1B_HUMAN-Phosphoserine882 relationship: transforms_into CCO:B0014075 ! SMC1B_HUMAN-Phosphoserine883 [Term] id: CCO:B0001978 name: PPC1B_HUMAN def: "Phosphatidic acid phosphatase type 2 domain-containing protein 1B" [UniProtKB:Q8NEB5] synonym: "EC 3.1.3.-" EXACT [UniProtKB:Q8NEB5] xref: EMBL:AAH33025.1 xref: EMBL:AAI06015.2 xref: EMBL:AAK14924.1 xref: UniProtKB:Q3KQX6 xref: UniProtKB:Q8NEB5 xref: UniProtKB:Q9BY45 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005363 ! PPAPDC1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001979 name: MNS1_HUMAN def: "Meiosis-specific nuclear structural protein 1" [UniProtKB:Q8NEH6] xref: EMBL:AAH31046.1 xref: EMBL:AAH34991.1 xref: EMBL:BAA92077.1 xref: UniProtKB:Q8IYT6 xref: UniProtKB:Q8NEH6 xref: UniProtKB:Q9NUP4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005106 ! MNS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0001980 name: DP13B_HUMAN def: "DCC-interacting protein 13-beta" [UniProtKB:Q8NEU8] synonym: "Adapter protein containing PH domain, PTB domain and leucine zipper motif 2" EXACT [UniProtKB:Q8NEU8] synonym: "Dip13-beta" EXACT [UniProtKB:Q8NEU8] xref: EMBL:AAH33731.1 xref: EMBL:AAM55530.1 xref: UniProtKB:Q8N4R7 xref: UniProtKB:Q8NEU8 xref: UniProtKB:Q9NVL2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004498 ! APPL2_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000351 ! endosome relationship: located_in CCO:C0000713 ! endosome membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000805 ! NuRD complex relationship: located_in CCO:C0001339 ! early endosome membrane relationship: participates_in CCO:I0005733 ! appl1-dip13b physical interaction relationship: participates_in CCO:I0005807 ! dip13b-rab22a physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001981 name: FLCN_HUMAN def: "Folliculin" [UniProtKB:Q8NFG4] synonym: "BHD skin lesion fibrofolliculoma protein" EXACT [UniProtKB:Q8NFG4] synonym: "Birt-Hogg-Dube syndrome protein" EXACT [UniProtKB:Q8NFG4] xref: EMBL:AAH15687.1 xref: EMBL:AAH15725.2 xref: EMBL:AAM94803.1 xref: EMBL:BAC86760.1 xref: EMBL:BAC87186.1 xref: EMBL:EAW55716.1 xref: UniProtKB:A6NJJ8 xref: UniProtKB:Q6ZRX1 xref: UniProtKB:Q8NFG4 xref: UniProtKB:Q96BD2 xref: UniProtKB:Q96BE4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004650 ! FLCN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001982 name: Q8NFI1_HUMAN def: "MLL/SEPTIN6 fusion protein" [UniProtKB:Q8NFI1] xref: EMBL:AAM82546.1 xref: UniProtKB:Q8NFI1 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001983 name: CADM4_HUMAN def: "Cell adhesion molecule 4 precursor" [UniProtKB:Q8NFZ8] synonym: "Immunoglobulin superfamily member 4C" EXACT [UniProtKB:Q8NFZ8] synonym: "Nectin-like protein 4" EXACT [UniProtKB:Q8NFZ8] synonym: "TSLC1-like protein 2" EXACT [UniProtKB:Q8NFZ8] xref: EMBL:AAC32740.1 xref: EMBL:AAM60750.1 xref: UniProtKB:Q8NFZ8 xref: UniProtKB:Q9Y4A4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004211 ! CADM4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0001984 name: NEK11_HUMAN def: "Serine/threonine-protein kinase Nek11" [UniProtKB:Q8NG66] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q8NG66] synonym: "Never in mitosis A-related kinase 11" EXACT [UniProtKB:Q8NG66] synonym: "NimA-related protein kinase 11" EXACT [UniProtKB:Q8NG66] xref: EMBL:AAH28587.1 xref: EMBL:BAB15672.1 xref: EMBL:BAC06350.1 xref: EMBL:BAC06351.1 xref: EMBL:CAI46114.1 xref: UniProtKB:Q5JPC0 xref: UniProtKB:Q8NG65 xref: UniProtKB:Q8NG66 xref: UniProtKB:Q8TBY1 xref: UniProtKB:Q9H5F4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005174 ! NEK11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006321 ! nek2-nek11-8 phosphorylation relationship: participates_in CCO:I0006730 ! nek2-nek11-6 physical interaction relationship: participates_in CCO:I0006870 ! nek2-nek11-2 colocalization relationship: participates_in CCO:I0006871 ! nek2-nek11-5 physical interaction relationship: participates_in CCO:I0006975 ! nek2-nek11-1 colocalization relationship: participates_in CCO:I0006976 ! nek2-nek11-7 phosphorylation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000186 ! intra-S DNA damage checkpoint [Term] id: CCO:B0001985 name: GA2L2_HUMAN def: "GAS2-like protein 2" [UniProtKB:Q8NHY3] synonym: "GAS2-related protein on chromosome 17" EXACT [UniProtKB:Q8NHY3] synonym: "Growth arrest-specific protein 2-like 2" EXACT [UniProtKB:Q8NHY3] xref: EMBL:AAM34264.1 xref: EMBL:AAM34265.1 xref: UniProtKB:Q8NHY3 xref: UniProtKB:Q8NHY4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004672 ! GAS2L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000421 ! cytoskeleton relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001986 name: CDC26_HUMAN def: "Anaphase-promoting complex subunit CDC26" [UniProtKB:Q8NHZ8] synonym: "Cell division cycle protein 26 homolog" EXACT [UniProtKB:Q8NHZ8] xref: EMBL:AAH42534.1 xref: EMBL:AAH66300.1 xref: EMBL:AAM34207.1 xref: EMBL:CAI10967.1 xref: UniProtKB:Q8NHZ8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004286 ! CDC26_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0011066 ! CDC26_HUMAN-Phosphoserine78 relationship: transforms_into CCO:B0011067 ! CDC26_HUMAN-Phosphoserine82 [Term] id: CCO:B0001987 name: G45IP_HUMAN def: "Growth arrest and DNA-damage-inducible proteins-interacting protein 1" [UniProtKB:Q8TAE8] synonym: "CKII beta-associating protein" EXACT [UniProtKB:Q8TAE8] synonym: "CR6-interacting factor 1" EXACT [UniProtKB:Q8TAE8] synonym: "CRIF1" EXACT [UniProtKB:Q8TAE8] synonym: "p53-responsive gene 6 protein" EXACT [UniProtKB:Q8TAE8] synonym: "Papillomavirus L2-interacting nuclear protein 1" EXACT [UniProtKB:Q8TAE8] synonym: "PLINP-1" EXACT [UniProtKB:Q8TAE8] xref: EMBL:AAH04944.1 xref: EMBL:AAH13027.2 xref: EMBL:AAH13039.2 xref: EMBL:AAH69200.1 xref: EMBL:AAL85877.1 xref: EMBL:AAM10639.1 xref: EMBL:CAC82499.1 xref: EMBL:CAD22344.1 xref: UniProtKB:Q8IVM3 xref: UniProtKB:Q8TAE8 xref: UniProtKB:Q8TE51 xref: UniProtKB:Q969P9 xref: UniProtKB:Q9BSM6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004670 ! GADD45GIP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001988 name: UHMK1_HUMAN def: "Serine/threonine-protein kinase Kist" [UniProtKB:Q8TAS1] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q8TAS1] synonym: "Kinase interacting with stathmin" EXACT [UniProtKB:Q8TAS1] synonym: "U2AF homology motif kinase 1" EXACT [UniProtKB:Q8TAS1] xref: EMBL:AAH14917.1 xref: EMBL:AAH26046.1 xref: EMBL:CAD60192.1 xref: EMBL:CAH70392.1 xref: UniProtKB:Q8TAS1 xref: UniProtKB:Q96C22 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005878 ! UHMK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0001989 name: UBA3_HUMAN def: "NEDD8-activating enzyme E1 catalytic subunit" [UniProtKB:Q8TBC4] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q8TBC4] synonym: "NEDD8-activating enzyme E1C" EXACT [UniProtKB:Q8TBC4] synonym: "Ubiquitin-activating enzyme 3" EXACT [UniProtKB:Q8TBC4] synonym: "Ubiquitin-activating enzyme E1C" EXACT [UniProtKB:Q8TBC4] synonym: "Ubiquitin-like modifier-activating enzyme 3" EXACT [UniProtKB:Q8TBC4] xref: EMBL:AAC27648.1 xref: EMBL:AAH22853.1 xref: EMBL:BAA33144.1 xref: EMBL:CAB55996.2 xref: UniProtKB:O76088 xref: UniProtKB:Q8TBC4 xref: UniProtKB:Q9NTU3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006416 ! UBA3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005974 ! ube1c-ube2m-1 direct interaction relationship: participates_in CCO:I0005976 ! nedd8-tp53-1 neddylation relationship: participates_in CCO:I0007022 ! appbp1-nedd8-1 physical interaction relationship: participates_in CCO:I0007023 ! appbp1-nedd8-2 physical interaction relationship: participates_in CCO:I0008348 ! ube1c-chd3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0001991 name: NEK9_HUMAN def: "Serine/threonine-protein kinase Nek9" [UniProtKB:Q8TD19] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q8TD19] synonym: "Nek8" EXACT [UniProtKB:Q8TD19] synonym: "Nercc1 kinase" EXACT [UniProtKB:Q8TD19] synonym: "Never in mitosis A-related kinase 9" EXACT [UniProtKB:Q8TD19] synonym: "NIMA-related kinase 8" EXACT [UniProtKB:Q8TD19] synonym: "NimA-related protein kinase 9" EXACT [UniProtKB:Q8TD19] xref: EMBL:AAD31936.1 xref: EMBL:AAD31938.1 xref: EMBL:AAD31939.1 xref: EMBL:AAD31940.1 xref: EMBL:AAH09336.2 xref: EMBL:AAH93881.1 xref: EMBL:AAI12102.1 xref: EMBL:AAL05428.1 xref: EMBL:AAL87410.1 xref: EMBL:BAC02704.1 xref: UniProtKB:Q52LK6 xref: UniProtKB:Q8NCN0 xref: UniProtKB:Q8TCY4 xref: UniProtKB:Q8TD19 xref: UniProtKB:Q9UPI4 xref: UniProtKB:Q9Y6S4 xref: UniProtKB:Q9Y6S5 xref: UniProtKB:Q9Y6S6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005179 ! NEK9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013151 ! NEK9_HUMAN-Phosphothreonine210 relationship: transforms_into CCO:B0013152 ! NEK9_HUMAN-Phosphoserine332 relationship: transforms_into CCO:B0013153 ! NEK9_HUMAN-Phosphothreonine333 relationship: transforms_into CCO:B0013154 ! NEK9_HUMAN-Phosphothreonine358 relationship: transforms_into CCO:B0013155 ! NEK9_HUMAN-Phosphoserine868 relationship: transforms_into CCO:B0013156 ! NEK9_HUMAN-Phosphoserine869 [Term] id: CCO:B0001992 name: BRSK1_HUMAN def: "BR serine/threonine-protein kinase 1" [UniProtKB:Q8TDC3] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q8TDC3] synonym: "SAD1 kinase" EXACT [UniProtKB:Q8TDC3] synonym: "Serine/threonine kinase SAD-B" EXACT [UniProtKB:Q8TDC3] xref: EMBL:AAH16681.1 xref: EMBL:AAL87697.1 xref: EMBL:AAL87698.1 xref: EMBL:AAS10354.1 xref: EMBL:AAS86442.1 xref: EMBL:BAB47440.1 xref: EMBL:CAD38595.1 xref: EMBL:CAD38950.2 xref: UniProtKB:Q5J5B5 xref: UniProtKB:Q8NDD0 xref: UniProtKB:Q8NDR4 xref: UniProtKB:Q8TDC2 xref: UniProtKB:Q8TDC3 xref: UniProtKB:Q96AV4 xref: UniProtKB:Q96JL4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004192 ! BRSK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000185 ! G2/M transition DNA damage checkpoint relationship: transforms_into CCO:B0010866 ! BRSK1_HUMAN-Phosphothreonine205 relationship: transforms_into CCO:B0010867 ! BRSK1_HUMAN-Phosphoserine209 [Term] id: CCO:B0001993 name: DLG5_HUMAN def: "Disks large homolog 5" [UniProtKB:Q8TDM6] synonym: "Discs large protein P-dlg" EXACT [UniProtKB:Q8TDM6] synonym: "Placenta and prostate DLG" EXACT [UniProtKB:Q8TDM6] xref: EMBL:AAC61295.1 xref: EMBL:AAH73996.1 xref: EMBL:AAI17696.1 xref: EMBL:AAL83937.1 xref: EMBL:AAL83938.1 xref: EMBL:BAA25509.2 xref: EMBL:BAC65420.1 xref: EMBL:CAI12103.1 xref: EMBL:CAI12104.2 xref: EMBL:CAI17323.1 xref: EMBL:CAI17324.2 xref: UniProtKB:Q149N1 xref: UniProtKB:Q5T1H7 xref: UniProtKB:Q5T1H8 xref: UniProtKB:Q6DKG3 xref: UniProtKB:Q86WC0 xref: UniProtKB:Q8TDM6 xref: UniProtKB:Q8TDM7 xref: UniProtKB:Q9UE73 xref: UniProtKB:Q9Y4E3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004479 ! DLG5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008438 ! terf1-dlg5 physical interaction relationship: transforms_into CCO:B0011525 ! DLG5_HUMAN-Phosphothreonine984 relationship: transforms_into CCO:B0011526 ! DLG5_HUMAN-Phosphoserine1000 relationship: transforms_into CCO:B0011527 ! DLG5_HUMAN-Phosphothreonine1011 [Term] id: CCO:B0001994 name: CABL1_HUMAN def: "CDK5 and ABL1 enzyme substrate 1" [UniProtKB:Q8TDN4] synonym: "Ik3-1" EXACT [UniProtKB:Q8TDN4] synonym: "Interactor with CDK3 1" EXACT [UniProtKB:Q8TDN4] xref: EMBL:AAH04124.2 xref: EMBL:AAH37218.1 xref: EMBL:AAL83906.1 xref: EMBL:BAC04107.1 xref: UniProtKB:Q8N3Y8 xref: UniProtKB:Q8NA22 xref: UniProtKB:Q8TDN4 xref: UniProtKB:Q9BTG1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004203 ! CABLES1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007352 ! cables1-tp53-3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000346 ! regulation of cell cycle relationship: transforms_into CCO:B0010871 ! CABL1_HUMAN-Phosphoserine168 relationship: transforms_into CCO:B0010872 ! CABL1_HUMAN-Phosphoserine313 [Term] id: CCO:B0001995 name: RBCC1_HUMAN def: "RB1-inducible coiled-coil protein 1" [UniProtKB:Q8TDY2] xref: EMBL:AAH17556.1 xref: EMBL:BAA13194.2 xref: EMBL:BAB69690.1 xref: UniProtKB:Q8TDY2 xref: UniProtKB:Q8WVU9 xref: UniProtKB:Q92601 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005443 ! RB1CC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013751 ! RBCC1_HUMAN-Phosphoserine237 relationship: transforms_into CCO:B0013752 ! RBCC1_HUMAN-Phosphoserine537 relationship: transforms_into CCO:B0013753 ! RBCC1_HUMAN-Phosphothreonine666 [Term] id: CCO:B0001996 name: PARD3_HUMAN def: "Partitioning-defective 3 homolog" [UniProtKB:Q8TEW0] synonym: "ASIP" EXACT [UniProtKB:Q8TEW0] synonym: "Atypical PKC isotype-specific-interacting protein" EXACT [UniProtKB:Q8TEW0] synonym: "CTCL tumor antigen se2-5" EXACT [UniProtKB:Q8TEW0] synonym: "PAR-3" EXACT [UniProtKB:Q8TEW0] synonym: "PAR3-alpha" EXACT [UniProtKB:Q8TEW0] synonym: "PARD-3" EXACT [UniProtKB:Q8TEW0] xref: EMBL:AAF71530.1 xref: EMBL:AAG33676.1 xref: EMBL:AAH11711.2 xref: EMBL:AAK27891.1 xref: EMBL:AAK27892.1 xref: EMBL:AAK69192.1 xref: EMBL:AAK69193.1 xref: EMBL:AAL76042.1 xref: EMBL:AAL76043.1 xref: EMBL:AAL76044.1 xref: EMBL:AAL76045.1 xref: EMBL:AAL76046.1 xref: EMBL:BAA91366.1 xref: EMBL:BAB55330.1 xref: EMBL:BAC54037.1 xref: UniProtKB:Q8TEW0 xref: UniProtKB:Q8TEW1 xref: UniProtKB:Q8TEW2 xref: UniProtKB:Q8TEW3 xref: UniProtKB:Q96K28 xref: UniProtKB:Q96RM6 xref: UniProtKB:Q96RM7 xref: UniProtKB:Q9BY57 xref: UniProtKB:Q9BY58 xref: UniProtKB:Q9HC48 xref: UniProtKB:Q9NWL4 xref: UniProtKB:Q9NYE6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005266 ! PARD3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006465 ! pard3-pard6a-1 physical interaction relationship: participates_in CCO:I0006466 ! pard6a-pard3-1 physical interaction relationship: participates_in CCO:I0006467 ! prcki-pard6-1 physical interaction relationship: participates_in CCO:I0007199 ! pard3-pard6b-2 physical interaction relationship: participates_in CCO:I0007200 ! pard3-pard6a-3 physical interaction relationship: participates_in CCO:I0007202 ! pard3-pard6a-2 physical interaction relationship: participates_in CCO:I0007211 ! prkci-pard3-1 physical interaction relationship: participates_in CCO:I0007212 ! ywhaz-pard3-1 physical interaction relationship: participates_in CCO:I0007218 ! pard3-ywhaz-1 physical interaction relationship: participates_in CCO:I0007219 ! ywhah-pard3-1 physical interaction relationship: participates_in CCO:I0007220 ! pard3-ywhah-1 physical interaction relationship: participates_in CCO:I0007221 ! pard3-prkci-2 physical interaction relationship: participates_in CCO:I0007231 ! pard3-pnma1-1 physical interaction relationship: participates_in CCO:I0007232 ! pnma1-pard3-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013391 ! PARD3_HUMAN-Phosphoserine144 relationship: transforms_into CCO:B0013392 ! PARD3_HUMAN-Phosphoserine383 relationship: transforms_into CCO:B0013393 ! PARD3_HUMAN-Phosphoserine717 relationship: transforms_into CCO:B0013394 ! PARD3_HUMAN-Phosphoserine827 relationship: transforms_into CCO:B0013395 ! PARD3_HUMAN-Phosphotyrosine1127 relationship: transforms_into CCO:B0041170 ! PARD3_HUMAN-Phosphoserine852 [Term] id: CCO:B0001997 name: PAR3L_HUMAN def: "Partitioning-defective 3 homolog B" [UniProtKB:Q8TEW8] synonym: "Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein" EXACT [UniProtKB:Q8TEW8] synonym: "PAR3-beta" EXACT [UniProtKB:Q8TEW8] synonym: "PAR3-L protein" EXACT [UniProtKB:Q8TEW8] synonym: "Partitioning-defective 3-like protein" EXACT [UniProtKB:Q8TEW8] xref: EMBL:AAL30664.1 xref: EMBL:AAL30665.1 xref: EMBL:AAL79827.1 xref: EMBL:BAB69028.1 xref: EMBL:BAB71106.1 xref: EMBL:BAB71623.1 xref: EMBL:BAC54035.1 xref: EMBL:BAC54285.1 xref: UniProtKB:Q8IUC7 xref: UniProtKB:Q8IUC9 xref: UniProtKB:Q8TEW8 xref: UniProtKB:Q96DK9 xref: UniProtKB:Q96N09 xref: UniProtKB:Q96NX6 xref: UniProtKB:Q96NX7 xref: UniProtKB:Q96Q29 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005261 ! PARD3B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013387 ! PAR3L_HUMAN-Phosphoserine368 relationship: transforms_into CCO:B0013388 ! PAR3L_HUMAN-Phosphoserine730 relationship: transforms_into CCO:B0013389 ! PAR3L_HUMAN-Phosphoserine746 relationship: transforms_into CCO:B0013390 ! PAR3L_HUMAN-Phosphoserine749 [Term] id: CCO:B0001998 name: Q8TEY4_HUMAN def: "Adaptor protein FE65a2" [UniProtKB:Q8TEY4] xref: EMBL:AAL79526.1 xref: UniProtKB:Q8TEY4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004076 ! APBB1_human relationship: has_function CCO:F0000136 ! beta-amyloid binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001738 ! transcription factor binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000935 ! lamellipodium relationship: located_in CCO:C0001006 ! growth cone relationship: located_in CCO:C0001900 ! synapse relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000244 ! negative regulation of S phase of mitotic cell cycle [Term] id: CCO:B0001999 name: HASP_HUMAN def: "Serine/threonine-protein kinase haspin" [UniProtKB:Q8TF76] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q8TF76] synonym: "Germ cell-specific gene 2 protein" EXACT [UniProtKB:Q8TF76] synonym: "H-haspin" EXACT [UniProtKB:Q8TF76] synonym: "Haploid germ cell-specific nuclear protein kinase" EXACT [UniProtKB:Q8TF76] xref: EMBL:AAH47457.1 xref: EMBL:AAK30300.1 xref: EMBL:BAB21938.3 xref: EMBL:BAB71255.1 xref: UniProtKB:Q5U5K3 xref: UniProtKB:Q8TF76 xref: UniProtKB:Q96MN1 xref: UniProtKB:Q9BXS7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004778 ! GSG2_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0008374 ! protein tyrosine kinase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012142 ! HASP_HUMAN-Phosphoserine220 relationship: transforms_into CCO:B0012143 ! HASP_HUMAN-Phosphothreonine253 [Term] id: CCO:B0002000 name: TUSC4_HUMAN def: "Tumor suppressor candidate 4" [UniProtKB:Q8WTW4] synonym: "G21 protein" EXACT [UniProtKB:Q8WTW4] synonym: "Gene 21 protein" EXACT [UniProtKB:Q8WTW4] synonym: "NPR2-like" EXACT [UniProtKB:Q8WTW4] xref: EMBL:AAB67310.1 xref: EMBL:AAC62535.1 xref: EMBL:AAC62536.1 xref: EMBL:AAH21984.1 xref: EMBL:AAH56861.1 xref: UniProtKB:Q8WTW4 xref: UniProtKB:Q9Y249 xref: UniProtKB:Q9Y497 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005845 ! TUSC4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002001 name: Q8WUE3_HUMAN def: "CCNE2 protein" [UniProtKB:Q8WUE3] synonym: "Cyclin E2, isoform CRA_a" EXACT [UniProtKB:Q8WUE3] xref: EMBL:AAH20729.1 xref: EMBL:EAW91727.1 xref: UniProtKB:Q8WUE3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004252 ! CCNE2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002003 name: SKA2_HUMAN def: "Spindle and kinetochore-associated protein 2" [UniProtKB:Q8WVK7] synonym: "Protein FAM33A" EXACT [UniProtKB:Q8WVK7] xref: EMBL:AAH17873.1 xref: EMBL:AAI06004.1 xref: UniProtKB:Q8WVK7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005620 ! FAM33A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000388 ! spindle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002004 name: STAG1_HUMAN def: "Cohesin subunit SA-1" [UniProtKB:Q8WVM7] synonym: "SCC3 homolog 1" EXACT [UniProtKB:Q8WVM7] synonym: "Stromal antigen 1" EXACT [UniProtKB:Q8WVM7] xref: EMBL:AAH17735.1 xref: EMBL:CAA99731.1 xref: UniProtKB:O00539 xref: UniProtKB:Q8WVM7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005683 ! STAG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007036 ! wapl-cspg6 physical interaction relationship: participates_in CCO:I0007037 ! wapl-cspg6-3 physical interaction relationship: participates_in CCO:I0007712 ! wapl-cspg6-5 physical interaction relationship: participates_in CCO:I0007713 ! wapl-cspg6-6 physical interaction relationship: participates_in CCO:I0007715 ! wapl-cspg6-9 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014239 ! STAG1_HUMAN-Phosphoserine1069 relationship: transforms_into CCO:B0014240 ! STAG1_HUMAN-Phosphoserine1070 [Term] id: CCO:B0002005 name: PCNP_HUMAN def: "PEST proteolytic signal-containing nuclear protein" [UniProtKB:Q8WW12] synonym: "PCNP" EXACT [UniProtKB:Q8WW12] synonym: "PEST-containing nuclear protein" EXACT [UniProtKB:Q8WW12] xref: EMBL:AAH13916.1 xref: EMBL:AAH22001.1 xref: EMBL:BAB03501.1 xref: EMBL:CAH10470.1 xref: UniProtKB:Q6AI44 xref: UniProtKB:Q8WW12 xref: UniProtKB:Q96CU3 xref: UniProtKB:Q9NS81 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005279 ! PCNP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013433 ! PCNP_HUMAN-Phosphothreonine66 relationship: transforms_into CCO:B0013434 ! PCNP_HUMAN-Phosphoserine69 relationship: transforms_into CCO:B0013435 ! PCNP_HUMAN-Phosphoserine77 relationship: transforms_into CCO:B0013436 ! PCNP_HUMAN-Phosphothreonine139 relationship: transforms_into CCO:B0013437 ! PCNP_HUMAN-Phosphoserine142 relationship: transforms_into CCO:B0013438 ! PCNP_HUMAN-Phosphoserine147 [Term] id: CCO:B0002006 name: CKAP2_HUMAN def: "Cytoskeleton-associated protein 2" [UniProtKB:Q8WWK9] synonym: "CTCL tumor antigen se20-10" EXACT [UniProtKB:Q8WWK9] synonym: "Tumor- and microtubule-associated protein" EXACT [UniProtKB:Q8WWK9] xref: EMBL:AAG33675.1 xref: EMBL:AAH10901.1 xref: EMBL:AAI05807.1 xref: EMBL:AAI30297.1 xref: EMBL:AAL47212.1 xref: EMBL:AAL47213.1 xref: EMBL:ABQ59042.1 xref: EMBL:BAA91788.1 xref: EMBL:BAB14345.1 xref: EMBL:CAB66782.2 xref: EMBL:CAC17466.1 xref: EMBL:CAD22295.1 xref: EMBL:CAH71660.2 xref: EMBL:CAH71661.2 xref: UniProtKB:A2BDE0 xref: UniProtKB:A5YM58 xref: UniProtKB:Q3KRA5 xref: UniProtKB:Q5VXB4 xref: UniProtKB:Q8IWV5 xref: UniProtKB:Q8IWV6 xref: UniProtKB:Q8WWK9 xref: UniProtKB:Q96FH9 xref: UniProtKB:Q9H012 xref: UniProtKB:Q9H0D0 xref: UniProtKB:Q9H988 xref: UniProtKB:Q9HC49 xref: UniProtKB:Q9NVG4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004361 ! CKAP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011235 ! CKAP2_HUMAN-Phosphoserine534 relationship: transforms_into CCO:B0011236 ! CKAP2_HUMAN-Phosphothreonine579 relationship: transforms_into CCO:B0011237 ! CKAP2_HUMAN-Phosphothreonine582 relationship: transforms_into CCO:B0011238 ! CKAP2_HUMAN-Phosphothreonine597 relationship: transforms_into CCO:B0011239 ! CKAP2_HUMAN-Phosphoserine602 relationship: transforms_into CCO:B0011240 ! CKAP2_HUMAN-Phosphoserine614 relationship: transforms_into CCO:B0011241 ! CKAP2_HUMAN-Phosphothreonine623 [Term] id: CCO:B0002007 name: CCNB3_HUMAN def: "G2/mitotic-specific cyclin-B3" [UniProtKB:Q8WWL7] xref: EMBL:CAB70806.1 xref: EMBL:CAC40024.1 xref: EMBL:CAC40025.1 xref: EMBL:CAC40026.1 xref: EMBL:CAC94915.1 xref: UniProtKB:Q8WWL7 xref: UniProtKB:Q96SB5 xref: UniProtKB:Q96SB6 xref: UniProtKB:Q96SB7 xref: UniProtKB:Q9NT38 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004246 ! CCNB3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0007901 ! cyclinb3_cdk2_human direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0002008 name: RASF5_HUMAN def: "Ras association domain-containing family protein 5" [UniProtKB:Q8WWW0] synonym: "New ras effector 1" EXACT [UniProtKB:Q8WWW0] synonym: "RAPL" EXACT [UniProtKB:Q8WWW0] synonym: "Regulator for cell adhesion and polarization enriched in lymphoid tissues" EXACT [UniProtKB:Q8WWW0] xref: EMBL:AAH04270.1 xref: EMBL:AAH07203.1 xref: EMBL:AAH42651.1 xref: EMBL:AAL38592.1 xref: EMBL:AAL40388.1 xref: EMBL:AAL40389.1 xref: EMBL:AAO61668.1 xref: EMBL:AAP83360.1 xref: EMBL:CAI13536.1 xref: EMBL:CAI13537.1 xref: EMBL:CAI13538.1 xref: EMBL:CAI13542.1 xref: EMBL:CAI15252.1 xref: EMBL:CAI15253.1 xref: EMBL:CAI15254.1 xref: EMBL:CAI15256.1 xref: EMBL:CAI46164.1 xref: UniProtKB:Q5SY32 xref: UniProtKB:Q8WWV9 xref: UniProtKB:Q8WWW0 xref: UniProtKB:Q8WXF4 xref: UniProtKB:Q9BT99 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005432 ! RASSF5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006951 ! stk4-rassf5-1 physical interaction relationship: participates_in CCO:I0007001 ! hras1-rassf5-2 physical interaction relationship: participates_in CCO:I0007002 ! rap1a-itgal-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002009 name: ATRIP_HUMAN def: "ATR-interacting protein" [UniProtKB:Q8WXE1] synonym: "ATM and Rad3-related-interacting protein" EXACT [UniProtKB:Q8WXE1] xref: EMBL:AAH14153.2 xref: EMBL:AAH20563.1 xref: EMBL:AAH30597.1 xref: EMBL:AAL38042.1 xref: EMBL:BAB14029.1 xref: UniProtKB:Q8NHQ2 xref: UniProtKB:Q8WUG7 xref: UniProtKB:Q8WXE1 xref: UniProtKB:Q96CL3 xref: UniProtKB:Q9HA30 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004122 ! ATRIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005811 ! atrip-ribc2 physical interaction relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: transforms_into CCO:B0010694 ! ATRIP_HUMAN-Phosphoserine518 [Term] id: CCO:B0002010 name: MADD_HUMAN def: "MAP kinase-activating death domain protein" [UniProtKB:Q8WXG6] synonym: "Differentially expressed in normal and neoplastic cells" EXACT [UniProtKB:Q8WXG6] synonym: "Insulinoma glucagonoma clone 20" EXACT [UniProtKB:Q8WXG6] synonym: "Rab3 GDP/GTP exchange factor" EXACT [UniProtKB:Q8WXG6] xref: EMBL:AAB57735.1 xref: EMBL:AAD12154.1 xref: EMBL:AAH40484.1 xref: EMBL:AAL35261.1 xref: EMBL:AAL40265.1 xref: EMBL:AAL40266.1 xref: EMBL:AAL40267.1 xref: EMBL:AAL40268.1 xref: EMBL:BAA20814.2 xref: UniProtKB:O15065 xref: UniProtKB:O15293 xref: UniProtKB:Q15732 xref: UniProtKB:Q15741 xref: UniProtKB:Q8IWD7 xref: UniProtKB:Q8WXG3 xref: UniProtKB:Q8WXG4 xref: UniProtKB:Q8WXG5 xref: UniProtKB:Q8WXG6 xref: UniProtKB:Q8WZ63 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005013 ! MADD_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000346 ! regulation of cell cycle relationship: transforms_into CCO:B0012757 ! MADD_HUMAN-Phosphoserine1059 relationship: transforms_into CCO:B0012758 ! MADD_HUMAN-Phosphothreonine1061 [Term] id: CCO:B0002011 name: SEPT1_HUMAN def: "Septin-1" [UniProtKB:Q8WYJ6] synonym: "LARP" EXACT [UniProtKB:Q8WYJ6] synonym: "Peanut-like protein 3" EXACT [UniProtKB:Q8WYJ6] synonym: "Serologically defined breast cancer antigen NY-BR-24" EXACT [UniProtKB:Q8WYJ6] xref: EMBL:AAG48256.1 xref: EMBL:AAH12161.1 xref: EMBL:AAK61491.1 xref: EMBL:AAL40393.1 xref: UniProtKB:Q8NEZ1 xref: UniProtKB:Q8WYJ6 xref: UniProtKB:Q96EL4 xref: UniProtKB:Q9H285 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005584 ! SEPT1_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:I0005780 ! sept1-sept6 physical interaction relationship: participates_in CCO:I0005863 ! sept1-tollip physical interaction relationship: participates_in CCO:I0005935 ! sept1-sept1 physical interaction relationship: participates_in CCO:I0006031 ! sept1-aurkb-5 phosphorylation relationship: participates_in CCO:I0006206 ! sept1-aurkb-2 physical interaction relationship: participates_in CCO:I0006533 ! sept1-aurkb-3 physical interaction relationship: participates_in CCO:I0006731 ! sept1-aurkb-4 physical interaction relationship: participates_in CCO:I0007357 ! sept1-aurkb-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002012 name: RSPH1_HUMAN def: "Radial spoke head 1 homolog" [UniProtKB:Q8WYR4] synonym: "Cancer/testis antigen 79" EXACT [UniProtKB:Q8WYR4] synonym: "CT79" EXACT [UniProtKB:Q8WYR4] synonym: "Male meiotic metaphase chromosome-associated acidic protein" EXACT [UniProtKB:Q8WYR4] synonym: "Meichroacidin" EXACT [UniProtKB:Q8WYR4] synonym: "Testis-specific gene A2 protein" EXACT [UniProtKB:Q8WYR4] xref: EMBL:AAI01520.1 xref: EMBL:AAI13368.1 xref: EMBL:BAB83694.1 xref: EMBL:BAB92995.1 xref: UniProtKB:Q3MJA1 xref: UniProtKB:Q8WYR4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005542 ! RSPH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0002013 name: TITIN_HUMAN def: "Titin" [UniProtKB:Q8WZ42] synonym: "Connectin" EXACT [UniProtKB:Q8WZ42] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q8WZ42] synonym: "Rhabdomyosarcoma antigen MU-RMS-40.14" EXACT [UniProtKB:Q8WZ42] xref: EMBL:AAD22603.1 xref: EMBL:AAD22604.1 xref: EMBL:AAH13396.1 xref: EMBL:AAH58824.1 xref: EMBL:AAH70170.1 xref: EMBL:AAI07798.1 xref: EMBL:AAP80791.1 xref: EMBL:ABB55264.1 xref: EMBL:CAA45938.1 xref: EMBL:CAA45939.1 xref: EMBL:CAA45940.1 xref: EMBL:CAA49245.1 xref: EMBL:CAA58243.1 xref: EMBL:CAA62188.1 xref: EMBL:CAA62189.1 xref: EMBL:CAA66795.1 xref: EMBL:CAA66796.1 xref: EMBL:CAD12455.1 xref: EMBL:CAD12456.1 xref: EMBL:CAD12457.1 xref: EMBL:CAD12458.1 xref: EMBL:CAD12459.1 xref: EMBL:CAD28458.1 xref: UniProtKB:Q10465 xref: UniProtKB:Q10466 xref: UniProtKB:Q15598 xref: UniProtKB:Q2XUS3 xref: UniProtKB:Q32Q60 xref: UniProtKB:Q4U1Z6 xref: UniProtKB:Q6NSG0 xref: UniProtKB:Q6PDB1 xref: UniProtKB:Q6PJP0 xref: UniProtKB:Q7KYM2 xref: UniProtKB:Q7KYN4 xref: UniProtKB:Q7KYN5 xref: UniProtKB:Q7LDM3 xref: UniProtKB:Q7Z2X3 xref: UniProtKB:Q8TCG8 xref: UniProtKB:Q8WZ42 xref: UniProtKB:Q8WZ51 xref: UniProtKB:Q8WZ52 xref: UniProtKB:Q8WZ53 xref: UniProtKB:Q8WZB3 xref: UniProtKB:Q92761 xref: UniProtKB:Q92762 xref: UniProtKB:Q9UD97 xref: UniProtKB:Q9UP84 xref: UniProtKB:Q9Y6L9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005786 ! TTN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006073 ! ttn-tcap direct interaction relationship: participates_in CCO:I0006732 ! actn2-ttn-4 physical interaction relationship: participates_in CCO:I0006733 ! ttn-ttn-1 physical interaction relationship: participates_in CCO:I0006743 ! ttn-obscn-3 physical interaction relationship: participates_in CCO:I0006874 ! ttn-actn2-5 physical interaction relationship: participates_in CCO:I0007004 ! ttn-obscn-1 physical interaction relationship: participates_in CCO:I0007124 ! actn2-ttn-3 physical interaction relationship: participates_in CCO:I0007125 ! actn2-ttn-6 physical interaction relationship: participates_in CCO:I0007452 ! ttn-obscn-2 physical interaction relationship: participates_in CCO:I0007571 ! ttn-actn2-1 physical interaction relationship: participates_in CCO:I0007758 ! actn2-ttn-2 physical interaction relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014381 ! TITIN_HUMAN-Phosphoserine33938 relationship: transforms_into CCO:B0014382 ! TITIN_HUMAN-Phosphoserine33942 relationship: transforms_into CCO:B0014383 ! TITIN_HUMAN-Phosphoserine9203 relationship: transforms_into CCO:B0014384 ! TITIN_HUMAN-Phosphothreonine9207 relationship: transforms_into CCO:B0014385 ! TITIN_HUMAN-Phosphoserine22525 relationship: transforms_into CCO:B0014386 ! TITIN_HUMAN-Phosphoserine22534 relationship: transforms_into CCO:B0014387 ! TITIN_HUMAN-Phosphotyrosine32341 relationship: transforms_into CCO:B0036036 ! TITIN_HUMAN-Phosphoserine4065 relationship: transforms_into CCO:B0036037 ! TITIN_HUMAN-Phosphoserine4068 [Term] id: CCO:B0002014 name: TSC1_HUMAN def: "Hamartin" [UniProtKB:Q92574] synonym: "Tuberous sclerosis 1 protein" EXACT [UniProtKB:Q92574] xref: EMBL:AAC51674.1 xref: EMBL:AAF61948.1 xref: EMBL:BAA13436.1 xref: UniProtKB:Q92574 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005839 ! TSC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 relationship: transforms_into CCO:B0014541 ! TSC1_HUMAN-Phosphoserine1102 [Term] id: CCO:B0002015 name: SEPT8_HUMAN def: "Septin-8" [UniProtKB:Q92599] xref: EMBL:AAG09407.1 xref: EMBL:AAH01329.1 xref: EMBL:AAO13878.1 xref: EMBL:AAO13879.1 xref: EMBL:AAO13880.1 xref: EMBL:BAA13193.1 xref: UniProtKB:Q8IX36 xref: UniProtKB:Q8IX37 xref: UniProtKB:Q92599 xref: UniProtKB:Q9BVB3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005591 ! SEPT8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006898 ! sept5-sept8 physical interaction relationship: participates_in CCO:I0007373 ! sept5-sept8-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014008 ! SEPT8_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0014009 ! SEPT8_HUMAN-Phosphoserine10 [Term] id: CCO:B0002016 name: RAD54_HUMAN def: "DNA repair and recombination protein RAD54-like" [UniProtKB:Q92698] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q92698] synonym: "hHR54" EXACT [UniProtKB:Q92698] synonym: "hRAD54" EXACT [UniProtKB:Q92698] synonym: "RAD54 homolog" EXACT [UniProtKB:Q92698] xref: EMBL:AAI21060.1 xref: EMBL:AAI21061.1 xref: EMBL:AAT38113.1 xref: EMBL:CAA66379.1 xref: EMBL:CAI22117.1 xref: UniProtKB:Q5TE31 xref: UniProtKB:Q6IUY3 xref: UniProtKB:Q92698 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005418 ! RAD54L_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000803 ! helicase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0002017 name: DDX12_HUMAN def: "Probable ATP-dependent RNA helicase DDX12" [UniProtKB:Q92771] synonym: "CHL1-related protein 2" EXACT [UniProtKB:Q92771] synonym: "DEAD/H box protein 12" EXACT [UniProtKB:Q92771] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q92771] synonym: "hCHLR2" EXACT [UniProtKB:Q92771] xref: EMBL:AAB06963.1 xref: UniProtKB:Q92771 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004455 ! DDX12_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000308 ! RNA binding relationship: has_function CCO:F0000487 ! ATP-dependent DNA helicase activity relationship: has_function CCO:F0000803 ! helicase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001682 ! ATP-dependent helicase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0003386 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002018 name: SC65_HUMAN def: "Synaptonemal complex protein SC65" [UniProtKB:Q92791] synonym: "Nucleolar autoantigen No55" EXACT [UniProtKB:Q92791] xref: EMBL:AAC51792.1 xref: EMBL:AAH01047.1 xref: EMBL:AAH07942.1 xref: EMBL:AAH11701.1 xref: EMBL:BAD96665.1 xref: EMBL:CAC16786.1 xref: UniProtKB:Q53GI6 xref: UniProtKB:Q92791 xref: UniProtKB:Q9H4F6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005200 ! SC65_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000121 ! synaptonemal complex assembly [Term] id: CCO:B0002019 name: PCAF_HUMAN def: "Histone acetyltransferase PCAF" [UniProtKB:Q92831] synonym: "EC 2.3.1.48" EXACT [UniProtKB:Q92831] synonym: "Histone acetylase PCAF" EXACT [UniProtKB:Q92831] synonym: "P/CAF" EXACT [UniProtKB:Q92831] synonym: "P300/CBP-associated factor" EXACT [UniProtKB:Q92831] xref: EMBL:AAC50890.2 xref: EMBL:AAH60823.1 xref: EMBL:AAH70075.1 xref: UniProtKB:Q6NSK1 xref: UniProtKB:Q92831 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005274 ! PCAF_human relationship: has_function CCO:F0000299 ! transcription cofactor activity relationship: has_function CCO:F0000300 ! transcription coactivator activity relationship: has_function CCO:F0000813 ! histone acetyltransferase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001700 ! N-acetyltransferase activity relationship: has_function CCO:F0001738 ! transcription factor binding relationship: has_function CCO:F0001882 ! acyltransferase activity relationship: has_function CCO:F0003130 ! acetyltransferase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0005720 ! histone deacetylase binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: participates_in CCO:I0006223 ! pcaf-hif1a physical interaction relationship: participates_in CCO:I0006352 ! pcaf-hif1a-1 physical interaction relationship: participates_in CCO:I0006564 ! tp53-nfya-3 physical interaction relationship: participates_in CCO:I0006917 ! nfya-tp53 physical interaction relationship: participates_in CCO:I0006919 ! tp53-nfya-5 physical interaction relationship: participates_in CCO:I0006958 ! sirt2-pcaf-myod1-2 physical interaction relationship: participates_in CCO:I0007368 ! pcaf-p66a physical interaction relationship: participates_in CCO:I0007369 ! pcaf-p66b-1 physical interaction relationship: participates_in CCO:I0007534 ! sirt2-pcaf-1 physical interaction relationship: participates_in CCO:I0007535 ! sirt2-pcaf-2 physical interaction relationship: participates_in CCO:I0007536 ! sirt2-pcaf-myod1-1 physical interaction relationship: participates_in CCO:I0007847 ! sirt2-pcaf-3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0041171 ! PCAF_HUMAN-Phosphoserine40 [Term] id: CCO:B0002020 name: APBB2_HUMAN def: "Amyloid beta A4 precursor protein-binding family B member 2" [UniProtKB:Q92870] synonym: "Fe65-like protein" EXACT [UniProtKB:Q92870] xref: EMBL:AAC50805.1 xref: EMBL:AAH27946.2 xref: UniProtKB:Q8IUI6 xref: UniProtKB:Q92870 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004077 ! APBB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006047 ! aplp2-apbb2-1 physical interaction relationship: participates_in CCO:I0006669 ! apbb2-app-2 physical interaction relationship: participates_in CCO:I0006992 ! apbb2 -app-1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000244 ! negative regulation of S phase of mitotic cell cycle [Term] id: CCO:B0002021 name: RAD50_HUMAN def: "DNA repair protein RAD50" [UniProtKB:Q92878] synonym: "EC 3.6.-.-" EXACT [UniProtKB:Q92878] synonym: "hRAD50" EXACT [UniProtKB:Q92878] xref: EMBL:AAB07119.1 xref: EMBL:AAD50325.1 xref: EMBL:AAD50326.1 xref: EMBL:AAH62603.1 xref: EMBL:AAH73850.1 xref: EMBL:CAA99729.1 xref: UniProtKB:O43254 xref: UniProtKB:Q6GMT7 xref: UniProtKB:Q6P5X3 xref: UniProtKB:Q92878 xref: UniProtKB:Q9UP86 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005415 ! RAD50_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006748 ! brca1-trrap-2 physical interaction relationship: participates_in CCO:I0006749 ! brca1-trrap-3 physical interaction relationship: participates_in CCO:I0006960 ! mdc1-atm-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000122 ! meiotic recombination relationship: transforms_into CCO:B0013665 ! RAD50_HUMAN-Phosphoserine237 relationship: transforms_into CCO:B0013666 ! RAD50_HUMAN-Phosphoserine635 relationship: transforms_into CCO:B0013667 ! RAD50_HUMAN-Phosphoserine640 relationship: transforms_into CCO:B0013668 ! RAD50_HUMAN-Phosphothreonine690 [Term] id: CCO:B0002024 name: RENT1_HUMAN def: "Regulator of nonsense transcripts 1" [UniProtKB:Q92900] synonym: "ATP-dependent helicase RENT1" EXACT [UniProtKB:Q92900] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q92900] synonym: "hUpf1" EXACT [UniProtKB:Q92900] synonym: "Nonsense mRNA reducing factor 1" EXACT [UniProtKB:Q92900] synonym: "NORF1" EXACT [UniProtKB:Q92900] synonym: "Up-frameshift suppressor 1 homolog" EXACT [UniProtKB:Q92900] xref: EMBL:AAB94785.1 xref: EMBL:AAC26788.1 xref: EMBL:AAC50771.1 xref: EMBL:AAC51140.1 xref: EMBL:AAH39817.1 xref: EMBL:BAA19664.2 xref: UniProtKB:O00239 xref: UniProtKB:O43343 xref: UniProtKB:Q86Z25 xref: UniProtKB:Q92842 xref: UniProtKB:Q92900 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005467 ! UPF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006015 ! lsm8-rent1 physical interaction relationship: participates_in CCO:I0006228 ! rent1-dcp2 physical interaction relationship: participates_in CCO:I0006229 ! dcp1a-upf1 physical interaction relationship: participates_in CCO:I0006230 ! dcp2-upf physical interaction relationship: participates_in CCO:I0006231 ! upf1-dcp1a-2 physical interaction relationship: participates_in CCO:I0006239 ! upf1-dcp1a-3 physical interaction relationship: participates_in CCO:I0006240 ! upf1-dcp1a-4 physical interaction relationship: participates_in CCO:I0006241 ! upf1-dcp1a-5 physical interaction relationship: participates_in CCO:I0006301 ! rent1-stau-2 physical interaction relationship: participates_in CCO:I0006499 ! rent1-u315 physical interaction relationship: participates_in CCO:I0006500 ! rent1-plekhb2 physical interaction relationship: participates_in CCO:I0006501 ! rent1-acas2 physical interaction relationship: participates_in CCO:I0006502 ! rent1-bat5 physical interaction relationship: participates_in CCO:I0006503 ! rent1-pepp2 physical interaction relationship: participates_in CCO:I0006504 ! rent1-c316g12_3 physical interaction relationship: participates_in CCO:I0006715 ! rent1-stau-3 physical interaction relationship: participates_in CCO:I0006716 ! rent1-stau-4 physical interaction relationship: participates_in CCO:I0007014 ! upf1-dcp1a physical interaction relationship: participates_in CCO:I0007015 ! upf1-dcp2 physical interaction relationship: participates_in CCO:I0007016 ! upf1-rcd8 physical interaction relationship: participates_in CCO:I0007249 ! rent1-stau-6 physical interaction relationship: participates_in CCO:I0007552 ! rent1-stau-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013819 ! RENT1_HUMAN-Phosphoserine1089 relationship: transforms_into CCO:B0013820 ! RENT1_HUMAN-Phosphoserine1107 relationship: transforms_into CCO:B0013821 ! RENT1_HUMAN-Phosphoserine1127 [Term] id: CCO:B0002025 name: CSN5_HUMAN def: "COP9 signalosome complex subunit 5" [UniProtKB:Q92905] synonym: "EC 3.4.-.-" EXACT [UniProtKB:Q92905] synonym: "Jun activation domain-binding protein 1" EXACT [UniProtKB:Q92905] synonym: "SGN5" EXACT [UniProtKB:Q92905] synonym: "Signalosome subunit 5" EXACT [UniProtKB:Q92905] xref: EMBL:AAB16847.1 xref: EMBL:AAD03468.1 xref: EMBL:AAH01187.1 xref: EMBL:AAH01859.1 xref: EMBL:AAH07272.1 xref: EMBL:AAL82571.1 xref: EMBL:CAG46479.1 xref: EMBL:CAH10375.1 xref: UniProtKB:O15386 xref: UniProtKB:Q6AW95 xref: UniProtKB:Q86WQ4 xref: UniProtKB:Q92905 xref: UniProtKB:Q9BQ17 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004408 ! COPS5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006461 ! cops5-cdkn1b physical interaction relationship: participates_in CCO:I0006658 ! gfi1b-cops5 physical interaction relationship: participates_in CCO:I0007044 ! cdn1b-cops5 colocalization relationship: participates_in CCO:I0007253 ! trx-jab1-cdn1b physical interaction relationship: transforms_into CCO:B0011362 ! CSN5_HUMAN-N-acetylalanine2 [Term] id: CCO:B0002026 name: NAT6_HUMAN def: "N-acetyltransferase 6" [UniProtKB:Q93015] synonym: "EC 2.3.1.-" EXACT [UniProtKB:Q93015] synonym: "Fus-2 protein" EXACT [UniProtKB:Q93015] synonym: "Fusion 2 protein" EXACT [UniProtKB:Q93015] xref: EMBL:AAC02732.1 xref: EMBL:AAC70912.1 xref: EMBL:AAC70913.1 xref: EMBL:AAH04483.2 xref: UniProtKB:Q93014 xref: UniProtKB:Q93015 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005157 ! NAT6_human relationship: has_function CCO:F0001700 ! N-acetyltransferase activity relationship: has_function CCO:F0001882 ! acyltransferase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0008451 ! c2f-nat6 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002027 name: CUL5_HUMAN def: "Cullin-5" [UniProtKB:Q93034] synonym: "CUL-5" EXACT [UniProtKB:Q93034] synonym: "VACM-1" EXACT [UniProtKB:Q93034] synonym: "Vasopressin-activated calcium-mobilizing receptor" EXACT [UniProtKB:Q93034] xref: EMBL:AAB70253.1 xref: EMBL:AAH63306.1 xref: EMBL:AAK07472.1 xref: EMBL:CAA57465.1 xref: UniProtKB:O14766 xref: UniProtKB:Q93034 xref: UniProtKB:Q9BZC6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004426 ! CUL5_human relationship: has_function CCO:F0001226 ! receptor activity relationship: has_function CCO:F0001525 ! calcium channel activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0004689 ! ubiquitin protein ligase binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001248 ! cullin-RING ubiquitin ligase complex relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002028 name: EXT2_HUMAN def: "Exostosin-2" [UniProtKB:Q93063] synonym: "EC 2.4.1.224" EXACT [UniProtKB:Q93063] synonym: "EC 2.4.1.225" EXACT [UniProtKB:Q93063] synonym: "Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase" EXACT [UniProtKB:Q93063] synonym: "Multiple exostoses protein 2" EXACT [UniProtKB:Q93063] synonym: "Putative tumor suppressor protein EXT2" EXACT [UniProtKB:Q93063] xref: EMBL:AAB07008.1 xref: EMBL:AAB62718.1 xref: EMBL:AAC50764.1 xref: EMBL:AAC51219.1 xref: EMBL:AAH10058.1 xref: UniProtKB:O15288 xref: UniProtKB:Q93063 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004603 ! EXT2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002029 name: TP4A1_HUMAN def: "Protein tyrosine phosphatase type IVA 1" [UniProtKB:Q93096] synonym: "EC 3.1.3.48" EXACT [UniProtKB:Q93096] synonym: "PRL-1" EXACT [UniProtKB:Q93096] synonym: "Protein-tyrosine phosphatase 4a1" EXACT [UniProtKB:Q93096] synonym: "Protein-tyrosine phosphatase of regenerating liver 1" EXACT [UniProtKB:Q93096] synonym: "PTP(CAAXI)" EXACT [UniProtKB:Q93096] xref: EMBL:AAB09080.1 xref: EMBL:AAB40597.1 xref: EMBL:AAC39836.1 xref: EMBL:AAH23975.1 xref: EMBL:AAH45571.1 xref: EMBL:CAC12761.1 xref: EMBL:CAH18292.1 xref: UniProtKB:O00648 xref: UniProtKB:Q49A54 xref: UniProtKB:Q93096 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005814 ! PTP4A1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002030 name: TBRG4_HUMAN def: "Protein TBRG4" [UniProtKB:Q969Z0] synonym: "Cell cycle progression protein 2" EXACT [UniProtKB:Q969Z0] synonym: "Cell cycle progression restoration protein 2" EXACT [UniProtKB:Q969Z0] synonym: "FAST kinase domain-containing protein 4" EXACT [UniProtKB:Q969Z0] synonym: "Transforming growth factor beta regulator 4" EXACT [UniProtKB:Q969Z0] xref: EMBL:AAB69312.1 xref: EMBL:AAH02732.2 xref: EMBL:AAH14918.1 xref: EMBL:AAH17235.1 xref: EMBL:BAA76792.2 xref: EMBL:BAD96663.1 xref: EMBL:CAD38700.1 xref: UniProtKB:O14710 xref: UniProtKB:Q53GI8 xref: UniProtKB:Q8NDM4 xref: UniProtKB:Q969Z0 xref: UniProtKB:Q9BUC6 xref: UniProtKB:Q9Y2F6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005746 ! TBRG4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0014320 ! TBRG4_HUMAN-Phosphothreonine65 [Term] id: CCO:B0002031 name: E2F7_HUMAN def: "Transcription factor E2F7" [UniProtKB:Q96AV8] synonym: "E2F-7" EXACT [UniProtKB:Q96AV8] xref: EMBL:AAH16658.1 xref: UniProtKB:A6NC74 xref: UniProtKB:Q96AV8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004539 ! E2F7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002032 name: SKA1_HUMAN def: "Spindle and kinetochore-associated protein 1" [UniProtKB:Q96BD8] xref: EMBL:AAH15706.1 xref: UniProtKB:Q96BD8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005619 ! SKA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000388 ! spindle relationship: participates_in CCO:I0005739 ! c18orf24-pldn physical interaction relationship: participates_in CCO:I0005888 ! c14orf48-c18orf24 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002033 name: PINX1_HUMAN def: "Pin2-interacting protein X1" [UniProtKB:Q96BK5] synonym: "Liver-related putative tumor suppressor" EXACT [UniProtKB:Q96BK5] synonym: "Protein 67-11-3" EXACT [UniProtKB:Q96BK5] synonym: "TRF1-interacting protein 1" EXACT [UniProtKB:Q96BK5] xref: EMBL:AAG18009.1 xref: EMBL:AAH15479.1 xref: EMBL:AAH93762.1 xref: EMBL:AAK31790.1 xref: EMBL:AAN31333.1 xref: EMBL:AAP37006.1 xref: EMBL:BAA91263.1 xref: EMBL:CAC51436.1 xref: UniProtKB:Q548A5 xref: UniProtKB:Q7Z7J8 xref: UniProtKB:Q96BK5 xref: UniProtKB:Q96QD7 xref: UniProtKB:Q9HBU7 xref: UniProtKB:Q9NWW2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005318 ! PINX1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008414 ! pafah1b2-pinx1 physical interaction relationship: participates_in CCO:I0008485 ! mpz-pinx1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002034 name: CCDC5_HUMAN def: "Coiled-coil domain-containing protein 5" [UniProtKB:Q96CS2] synonym: "Enhancer of invasion-cluster" EXACT [UniProtKB:Q96CS2] synonym: "HEI-C" EXACT [UniProtKB:Q96CS2] xref: EMBL:AAH05958.1 xref: EMBL:AAH14003.1 xref: EMBL:AAQ63649.1 xref: EMBL:BAC05036.1 xref: UniProtKB:Q8N837 xref: UniProtKB:Q96CS2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004240 ! CCDC5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002035 name: CHFR_HUMAN def: "E3 ubiquitin-protein ligase CHFR" [UniProtKB:Q96EP1] synonym: "Checkpoint with forkhead and RING finger domains protein" EXACT [UniProtKB:Q96EP1] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q96EP1] synonym: "RING finger protein 196" EXACT [UniProtKB:Q96EP1] xref: EMBL:AAF91084.1 xref: EMBL:AAH12072.1 xref: EMBL:BAA91817.1 xref: EMBL:BAB55297.1 xref: EMBL:CAB70812.1 xref: UniProtKB:Q96EP1 xref: UniProtKB:Q96SL3 xref: UniProtKB:Q9NRT4 xref: UniProtKB:Q9NT32 xref: UniProtKB:Q9NVD5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004346 ! CHFR_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008375 ! chfr-eef1g physical interaction relationship: participates_in CCO:I0008450 ! brd4-chfr physical interaction relationship: participates_in CCO:I0008459 ! chfr-gabbr1 physical interaction relationship: participates_in CCO:I0008460 ! chfr-itgae physical interaction relationship: participates_in CCO:I0008461 ! chfr-wdr47 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint relationship: transforms_into CCO:B0011210 ! CHFR_HUMAN-Phosphothreonine130 relationship: transforms_into CCO:B0011211 ! CHFR_HUMAN-Phosphothreonine386 [Term] id: CCO:B0002036 name: MCRS1_HUMAN def: "Microspherule protein 1" [UniProtKB:Q96EZ8] synonym: "58 kDa microspherule protein" EXACT [UniProtKB:Q96EZ8] synonym: "Cell cycle-regulated factor p78" EXACT [UniProtKB:Q96EZ8] synonym: "MCRS2" EXACT [UniProtKB:Q96EZ8] xref: EMBL:AAC52086.1 xref: EMBL:AAC68599.1 xref: EMBL:AAH11794.1 xref: EMBL:AAQ84517.1 xref: UniProtKB:O14742 xref: UniProtKB:O75497 xref: UniProtKB:Q6VN53 xref: UniProtKB:Q96EZ8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005044 ! MCRS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007777 ! mcrs1-ruvbl physical interaction relationship: transforms_into CCO:B0012840 ! MCRS1_HUMAN-Phosphothreonine103 relationship: transforms_into CCO:B0012841 ! MCRS1_HUMAN-Phosphoserine108 relationship: transforms_into CCO:B0012842 ! MCRS1_HUMAN-Phosphoserine282 [Term] id: CCO:B0002037 name: DDX11_HUMAN def: "Probable ATP-dependent RNA helicase DDX11" [UniProtKB:Q96FC9] synonym: "CHL1-related protein 1" EXACT [UniProtKB:Q96FC9] synonym: "DEAD/H box protein 11" EXACT [UniProtKB:Q96FC9] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q96FC9] synonym: "hCHLR1" EXACT [UniProtKB:Q96FC9] synonym: "Keratinocyte growth factor-regulated gene 2 protein" EXACT [UniProtKB:Q96FC9] synonym: "KRG-2" EXACT [UniProtKB:Q96FC9] xref: EMBL:AAB06962.1 xref: EMBL:AAB18749.1 xref: EMBL:AAB18750.1 xref: EMBL:AAH50069.1 xref: EMBL:AAH50522.1 xref: EMBL:CAA67895.1 xref: UniProtKB:Q13333 xref: UniProtKB:Q86VQ4 xref: UniProtKB:Q86W62 xref: UniProtKB:Q92498 xref: UniProtKB:Q92770 xref: UniProtKB:Q92998 xref: UniProtKB:Q92999 xref: UniProtKB:Q96FC9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004454 ! DDX11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation relationship: participates_in CCO:P0000014 ! S phase of mitotic cell cycle relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002038 name: CDCA5_HUMAN def: "Sororin" [UniProtKB:Q96FF9] synonym: "Cell division cycle-associated protein 5" EXACT [UniProtKB:Q96FF9] synonym: "p35" EXACT [UniProtKB:Q96FF9] xref: EMBL:AAH11000.1 xref: UniProtKB:Q96FF9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004297 ! CDCA5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008369 ! cdca5-g22p1 physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: participates_in CCO:P0000094 ! mitotic metaphase plate congression relationship: participates_in CCO:P0000324 ! interphase of mitotic cell cycle relationship: transforms_into CCO:B0011098 ! CDCA5_HUMAN-Phosphothreonine48 relationship: transforms_into CCO:B0011099 ! CDCA5_HUMAN-Phosphoserine50 relationship: transforms_into CCO:B0011100 ! CDCA5_HUMAN-Phosphoserine75 relationship: transforms_into CCO:B0011101 ! CDCA5_HUMAN-Phosphoserine79 [Term] id: CCO:B0002039 name: SIPA1_HUMAN def: "Signal-induced proliferation-associated protein 1" [UniProtKB:Q96FS4] synonym: "GTPase-activating protein Spa-1" EXACT [UniProtKB:Q96FS4] synonym: "p130 SPA-1" EXACT [UniProtKB:Q96FS4] synonym: "Sipa-1" EXACT [UniProtKB:Q96FS4] xref: EMBL:AAC32547.1 xref: EMBL:AAC32559.1 xref: EMBL:AAH10492.1 xref: EMBL:AAI10354.1 xref: EMBL:BAA22197.1 xref: UniProtKB:O14518 xref: UniProtKB:O60484 xref: UniProtKB:O60618 xref: UniProtKB:Q2YD83 xref: UniProtKB:Q96FS4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005616 ! SIPA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0014063 ! SIPA1_HUMAN-Phosphoserine74 [Term] id: CCO:B0002040 name: AURKB_HUMAN def: "Serine/threonine-protein kinase 12" [UniProtKB:Q96GD4] synonym: "AIM-1" EXACT [UniProtKB:Q96GD4] synonym: "Aurora- and Ipl1-like midbody-associated protein 1" EXACT [UniProtKB:Q96GD4] synonym: "Aurora-B" EXACT [UniProtKB:Q96GD4] synonym: "Aurora-related kinase 2" EXACT [UniProtKB:Q96GD4] synonym: "Aurora/IPL1-related kinase 2" EXACT [UniProtKB:Q96GD4] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q96GD4] synonym: "STK-1" EXACT [UniProtKB:Q96GD4] xref: EMBL:AAB65786.1 xref: EMBL:AAC12709.1 xref: EMBL:AAC98891.1 xref: EMBL:AAH00442.3 xref: EMBL:AAH09751.1 xref: EMBL:AAH13300.2 xref: EMBL:AAH80581.1 xref: EMBL:AAV38341.1 xref: EMBL:BAA32136.1 xref: EMBL:BAA82709.1 xref: UniProtKB:O14630 xref: UniProtKB:O60446 xref: UniProtKB:O95083 xref: UniProtKB:Q96DV5 xref: UniProtKB:Q96GD4 xref: UniProtKB:Q9UQ46 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004129 ! AURKB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006031 ! sept1-aurkb-5 phosphorylation relationship: participates_in CCO:I0006206 ! sept1-aurkb-2 physical interaction relationship: participates_in CCO:I0006533 ! sept1-aurkb-3 physical interaction relationship: participates_in CCO:I0006731 ! sept1-aurkb-4 physical interaction relationship: participates_in CCO:I0007353 ! tacc1-aurkb-5 physical interaction relationship: participates_in CCO:I0007357 ! sept1-aurkb-1 physical interaction relationship: participates_in CCO:I0007423 ! tacc1-aurkb-4 physical interaction relationship: participates_in CCO:I0008448 ! aurkb-tbl3 physical interaction relationship: participates_in CCO:I0008474 ! flj10415-aurkb physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0010722 ! AURKB_HUMAN-Phosphoserine7 relationship: transforms_into CCO:B0010723 ! AURKB_HUMAN-Phosphotyrosine12 relationship: transforms_into CCO:B0010724 ! AURKB_HUMAN-Phosphothreonine232 [Term] id: CCO:B0002041 name: SENP5_HUMAN def: "Sentrin-specific protease 5" [UniProtKB:Q96HI0] synonym: "EC 3.4.22.-" EXACT [UniProtKB:Q96HI0] synonym: "Sentrin/SUMO-specific protease SENP5" EXACT [UniProtKB:Q96HI0] xref: EMBL:AAH08589.1 xref: EMBL:AAH30705.1 xref: EMBL:AAK69630.1 xref: UniProtKB:Q96HI0 xref: UniProtKB:Q96SA5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005579 ! SENP5_human relationship: has_function CCO:F0001783 ! peptidase activity relationship: has_function CCO:F0001784 ! cysteine-type peptidase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002042 name: SGSM3_HUMAN def: "Small G protein signaling modulator 3" [UniProtKB:Q96HU1] synonym: "Merlin-associated protein" EXACT [UniProtKB:Q96HU1] synonym: "Rab-GTPase-activating protein-like protein" EXACT [UniProtKB:Q96HU1] synonym: "RabGAPLP" EXACT [UniProtKB:Q96HU1] synonym: "RUN and TBC1 domain-containing protein 3" EXACT [UniProtKB:Q96HU1] xref: EMBL:AAH08078.1 xref: EMBL:AAQ81879.1 xref: EMBL:BAE02561.1 xref: EMBL:BAF63513.1 xref: EMBL:CAA18266.1 xref: EMBL:CAB70773.1 xref: EMBL:CAG30327.1 xref: EMBL:EAW60378.1 xref: EMBL:EAW60379.1 xref: UniProtKB:Q7Z709 xref: UniProtKB:Q96HU1 xref: UniProtKB:Q9NT69 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005603 ! SGSM3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002043 name: NSL1_HUMAN def: "Kinetochore-associated protein NSL1 homolog" [UniProtKB:Q96IY1] xref: EMBL:AAF86877.1 xref: EMBL:AAG44640.1 xref: EMBL:AAH07067.1 xref: EMBL:CAB43260.1 xref: EMBL:CAI17046.1 xref: UniProtKB:Q5SY75 xref: UniProtKB:Q96IY1 xref: UniProtKB:Q9H2M5 xref: UniProtKB:Q9NRN8 xref: UniProtKB:Q9Y415 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005216 ! NSL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013262 ! NSL1_HUMAN-Phosphoserine24 relationship: transforms_into CCO:B0013263 ! NSL1_HUMAN-Phosphothreonine242 [Term] id: CCO:B0002044 name: CK5P3_HUMAN def: "CDK5 regulatory subunit-associated protein 3" [UniProtKB:Q96JB5] synonym: "CDK5 activator-binding protein C53" EXACT [UniProtKB:Q96JB5] synonym: "Protein HSF-27" EXACT [UniProtKB:Q96JB5] xref: EMBL:AAG17225.1 xref: EMBL:AAG39277.1 xref: EMBL:AAH09957.1 xref: EMBL:AAH72435.1 xref: EMBL:AAK69655.1 xref: EMBL:BAB14657.1 xref: EMBL:BAB93496.1 xref: EMBL:BAD97107.1 xref: UniProtKB:Q53FA2 xref: UniProtKB:Q96JB5 xref: UniProtKB:Q9H3F8 xref: UniProtKB:Q9H8G0 xref: UniProtKB:Q9HBR9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004360 ! CDK5RAP3_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0005717 ! neuronal Cdc2-like kinase binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:I0006575 ! disc1-cdk5rap3-1 physical interaction relationship: participates_in CCO:I0006576 ! disc1-cdk5rap3-2 physical interaction relationship: participates_in CCO:I0006799 ! disc1-cdk5rap3 physical interaction relationship: participates_in CCO:I0008370 ! cdk5rap3-crmp1 physical interaction relationship: participates_in CCO:I0008455 ! cdk5rap3-srprb physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity [Term] id: CCO:B0002045 name: TOPK_HUMAN def: "Lymphokine-activated killer T-cell-originated protein kinase" [UniProtKB:Q96KB5] synonym: "Cancer/testis antigen 84" EXACT [UniProtKB:Q96KB5] synonym: "CT84" EXACT [UniProtKB:Q96KB5] synonym: "EC 2.7.12.2" EXACT [UniProtKB:Q96KB5] synonym: "MAPKK-like protein kinase" EXACT [UniProtKB:Q96KB5] synonym: "Nori-3" EXACT [UniProtKB:Q96KB5] synonym: "PDZ-binding kinase" EXACT [UniProtKB:Q96KB5] synonym: "Spermatogenesis-related protein kinase" EXACT [UniProtKB:Q96KB5] synonym: "SPK" EXACT [UniProtKB:Q96KB5] synonym: "T-LAK cell-originated protein kinase" EXACT [UniProtKB:Q96KB5] xref: EMBL:AAF69107.1 xref: EMBL:AAF71521.1 xref: EMBL:AAH15191.1 xref: EMBL:BAA99576.1 xref: EMBL:BAA99577.1 xref: EMBL:BAB55019.1 xref: UniProtKB:Q96KB5 xref: UniProtKB:Q9NPD9 xref: UniProtKB:Q9NYL7 xref: UniProtKB:Q9NZK6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005813 ! PBK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005924 ! pbk-trim37 physical interaction relationship: participates_in CCO:I0006965 ! araf-pbk physical interaction relationship: participates_in CCO:I0007554 ! araf-pbk-1 physical interaction relationship: participates_in CCO:I0007555 ! araf-pbk-2 physical interaction relationship: participates_in CCO:I0007860 ! raf1-pbk physical interaction relationship: participates_in CCO:I0008176 ! pbk-gps2 physical interaction relationship: participates_in CCO:I0008342 ! pbk-kiaa1377 physical interaction relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014448 ! TOPK_HUMAN-Phosphoserine59 relationship: transforms_into CCO:B0014449 ! TOPK_HUMAN-Phosphothreonine200 [Term] id: CCO:B0002046 name: ASPP1_HUMAN def: "Apoptosis-stimulating of p53 protein 1" [UniProtKB:Q96KQ4] synonym: "Protein phosphatase 1 regulatory subunit 13B" EXACT [UniProtKB:Q96KQ4] xref: EMBL:BAA34491.1 xref: EMBL:CAC83011.2 xref: UniProtKB:O94870 xref: UniProtKB:Q96KQ4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004109 ! PPP1R13B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006599 ! cdc5l-ppp1r13b physical interaction relationship: participates_in CCO:I0006600 ! tnik-ppp1r13b physical interaction relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0010628 ! ASPP1_HUMAN-Phosphoserine332 relationship: transforms_into CCO:B0010629 ! ASPP1_HUMAN-Phosphoserine335 relationship: transforms_into CCO:B0010630 ! ASPP1_HUMAN-Phosphoserine671 [Term] id: CCO:B0002047 name: LMLN_HUMAN def: "Leishmanolysin-like peptidase" [UniProtKB:Q96KR4] synonym: "EC 3.4.24.-" EXACT [UniProtKB:Q96KR4] synonym: "Invadolysin" EXACT [UniProtKB:Q96KR4] xref: EMBL:CAC42882.1 xref: EMBL:CAC42883.1 xref: UniProtKB:Q96KR4 xref: UniProtKB:Q96KR5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004984 ! LMLN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002048 name: Q96LE1_HUMAN def: "Cyclin-dependent kinase inhibitor isoform" [UniProtKB:Q96LE1] xref: EMBL:AAG15411.1 xref: UniProtKB:Q96LE1 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0001217 ! cyclin-dependent protein kinase inhibitor activity relationship: has_function CCO:F0003114 ! kinase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002049 name: HEXI2_HUMAN def: "Protein HEXIM2" [UniProtKB:Q96MH2] synonym: "Hexamethylene bis-acetamide-inducible protein 2" EXACT [UniProtKB:Q96MH2] xref: EMBL:AAH03531.1 xref: EMBL:AAH12474.1 xref: EMBL:AAH25970.1 xref: EMBL:AAT06733.1 xref: EMBL:BAB71319.1 xref: EMBL:EAW51541.1 xref: UniProtKB:Q96MH2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004802 ! HEXIM2_human relationship: has_function CCO:F0001217 ! cyclin-dependent protein kinase inhibitor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003206 ! transcription repressor activity relationship: has_function CCO:F0003544 ! snRNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity relationship: transforms_into CCO:B0012182 ! HEXI2_HUMAN-Phosphoserine51 relationship: transforms_into CCO:B0012183 ! HEXI2_HUMAN-Phosphoserine53 [Term] id: CCO:B0002050 name: Q96MY5_HUMAN def: "Septin" [UniProtKB:Q96MY5] xref: EMBL:BAB71133.1 xref: EMBL:EAX03032.1 xref: UniProtKB:Q96MY5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006040 ! hCG_2002594_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002051 name: CCD16_HUMAN def: "Coiled-coil domain-containing protein 16" [UniProtKB:Q96NB3] xref: EMBL:AAH02913.2 xref: EMBL:AAH09044.1 xref: EMBL:AAH11584.1 xref: EMBL:BAB70992.1 xref: UniProtKB:Q96F60 xref: UniProtKB:Q96GZ5 xref: UniProtKB:Q96NB3 xref: UniProtKB:Q9BU38 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004237 ! CCDC16_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0010980 ! CCD16_HUMAN-Phosphoserine89 relationship: transforms_into CCO:B0010981 ! CCD16_HUMAN-Phosphoserine351 relationship: transforms_into CCO:B0010982 ! CCD16_HUMAN-Phosphoserine362 [Term] id: CCO:B0002052 name: CEND2_HUMAN def: "Centaurin-delta-2" [UniProtKB:Q96P48] synonym: "Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1" EXACT [UniProtKB:Q96P48] synonym: "Cnt-d2" EXACT [UniProtKB:Q96P48] xref: EMBL:AAH08315.1 xref: EMBL:AAH56401.1 xref: EMBL:AAL04167.1 xref: EMBL:AAL12169.1 xref: EMBL:BAA34502.2 xref: EMBL:BAD92710.1 xref: EMBL:CAF21317.1 xref: UniProtKB:O94879 xref: UniProtKB:Q4LDD5 xref: UniProtKB:Q59FI7 xref: UniProtKB:Q6PHS3 xref: UniProtKB:Q8WU51 xref: UniProtKB:Q96HP6 xref: UniProtKB:Q96L71 xref: UniProtKB:Q96P48 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004321 ! CENTD2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007575 ! g22p1-centd2-1 physical interaction relationship: participates_in CCO:I0008066 ! arih2-centd2 physical interaction relationship: participates_in CCO:I0008232 ! fgfr3-centd2 physical interaction relationship: participates_in CCO:I0008358 ! arpc3-centd2 physical interaction relationship: participates_in CCO:I0008373 ! centd2-g22p1 physical interaction relationship: participates_in CCO:P0000161 ! actin filament reorganization during cell cycle relationship: transforms_into CCO:B0011133 ! CEND2_HUMAN-Phosphothreonine114 relationship: transforms_into CCO:B0011134 ! CEND2_HUMAN-Phosphotyrosine497 [Term] id: CCO:B0002053 name: MACF4_HUMAN def: "Microtubule-actin cross-linking factor 1, isoform 4" [UniProtKB:Q96PK2] xref: EMBL:AAL09459.1 xref: EMBL:AAL38997.1 xref: UniProtKB:Q8WXY1 xref: UniProtKB:Q96PK2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005012 ! MACF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0012752 ! MACF4_HUMAN-Phosphoserine2576 relationship: transforms_into CCO:B0012753 ! MACF4_HUMAN-Phosphoserine2577 relationship: transforms_into CCO:B0012754 ! MACF4_HUMAN-Phosphoserine2579 relationship: transforms_into CCO:B0012755 ! MACF4_HUMAN-Phosphothreonine5627 relationship: transforms_into CCO:B0012756 ! MACF4_HUMAN-Phosphothreonine5823 [Term] id: CCO:B0002054 name: UHRF2_HUMAN def: "E3 ubiquitin-protein ligase UHRF2" [UniProtKB:Q96PU4] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q96PU4] synonym: "Np95-like RING finger protein" EXACT [UniProtKB:Q96PU4] synonym: "Np95/ICBP90-like RING finger protein" EXACT [UniProtKB:Q96PU4] synonym: "Nuclear zinc finger protein Np97" EXACT [UniProtKB:Q96PU4] synonym: "RING finger protein 107" EXACT [UniProtKB:Q96PU4] synonym: "Ubiquitin-like PHD and RING finger domain-containing protein 2" EXACT [UniProtKB:Q96PU4] synonym: "Ubiquitin-like-containing PHD and RING finger domains protein 2" EXACT [UniProtKB:Q96PU4] xref: EMBL:AAH28397.1 xref: EMBL:AAM33799.1 xref: EMBL:BAB68317.1 xref: EMBL:CAH56383.1 xref: EMBL:CAH74119.1 xref: EMBL:CAH74120.1 xref: EMBL:CAI13293.1 xref: EMBL:CAI13295.1 xref: UniProtKB:Q5VYR1 xref: UniProtKB:Q5VYR3 xref: UniProtKB:Q659C8 xref: UniProtKB:Q8TAG7 xref: UniProtKB:Q96PU4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005880 ! UHRF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006027 ! uhrf2-cdk2-1 physical interaction relationship: participates_in CCO:I0006028 ! uhrf2-cdk2-3 physical interaction relationship: participates_in CCO:I0007120 ! uhrf2-cdk2-4 direct interaction relationship: participates_in CCO:I0007419 ! uhrf2-cdk2-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000346 ! regulation of cell cycle [Term] id: CCO:B0002055 name: NEK1_HUMAN def: "Serine/threonine-protein kinase Nek1" [UniProtKB:Q96PY6] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q96PY6] synonym: "NimA-related protein kinase 1" EXACT [UniProtKB:Q96PY6] synonym: "Renal carcinoma antigen NY-REN-55" EXACT [UniProtKB:Q96PY6] xref: EMBL:AAD42879.1 xref: EMBL:BAB67794.1 xref: UniProtKB:Q96PY6 xref: UniProtKB:Q9Y594 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005175 ! NEK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006164 ! nek1-fez1-2 physical interaction relationship: participates_in CCO:I0006165 ! nek1-fez2-1 physical interaction relationship: participates_in CCO:I0006481 ! exosc4-nek1 physical interaction relationship: participates_in CCO:I0007235 ! nek1-fez2-2 physical interaction relationship: participates_in CCO:I0007268 ! nek1-fez1-3 physical interaction relationship: participates_in CCO:I0007269 ! nek1-ywhah-1 physical interaction relationship: participates_in CCO:I0007270 ! nek1-xh2-1 physical interaction relationship: participates_in CCO:I0007271 ! nek1-mre11-1 physical interaction relationship: participates_in CCO:I0007272 ! nek1-tp53bp1-1 physical interaction relationship: participates_in CCO:I0007273 ! nek1-kif3a physical interaction relationship: participates_in CCO:I0007274 ! nek1-ppp2r5d-1 physical interaction relationship: participates_in CCO:I0007275 ! nek1-tsc2-1 physical interaction relationship: participates_in CCO:I0007276 ! nek1-ctnnal1-1 physical interaction relationship: participates_in CCO:I0007277 ! nek1-tsc2-2 physical interaction relationship: participates_in CCO:I0007278 ! nek1-tsc2-3 physical interaction relationship: participates_in CCO:I0007279 ! nek1-nek1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013145 ! NEK1_HUMAN-Phosphothreonine162 relationship: transforms_into CCO:B0013146 ! NEK1_HUMAN-Phosphoserine664 relationship: transforms_into CCO:B0013147 ! NEK1_HUMAN-Phosphoserine1126 [Term] id: CCO:B0002056 name: MPPH1_HUMAN def: "M-phase phosphoprotein 1" [UniProtKB:Q96Q89] synonym: "Cancer/testis antigen 90" EXACT [UniProtKB:Q96Q89] synonym: "CT90" EXACT [UniProtKB:Q96Q89] synonym: "Kinesin-related motor interacting with PIN1" EXACT [UniProtKB:Q96Q89] synonym: "MPP1" EXACT [UniProtKB:Q96Q89] xref: EMBL:AAB88727.1 xref: EMBL:AAC37542.1 xref: EMBL:AAH12585.1 xref: EMBL:AAH46134.1 xref: EMBL:AAH58913.1 xref: EMBL:AAH93089.1 xref: EMBL:AAI08689.1 xref: EMBL:AAP40330.1 xref: EMBL:AAP40331.1 xref: EMBL:AAW65984.1 xref: EMBL:BAB15043.1 xref: EMBL:BAB15194.1 xref: EMBL:BAB20417.1 xref: EMBL:BAB69456.1 xref: EMBL:CAB55962.1 xref: EMBL:CAB70720.1 xref: EMBL:CAI12885.1 xref: EMBL:CAI12886.1 xref: EMBL:CAI12887.1 xref: EMBL:CAI16829.1 xref: EMBL:CAI16830.1 xref: EMBL:CAI16831.1 xref: EMBL:CAI16832.1 xref: UniProtKB:O43277 xref: UniProtKB:Q09471 xref: UniProtKB:Q2KQ73 xref: UniProtKB:Q32NE1 xref: UniProtKB:Q561V3 xref: UniProtKB:Q58EX8 xref: UniProtKB:Q5T9M8 xref: UniProtKB:Q5T9M9 xref: UniProtKB:Q5T9N0 xref: UniProtKB:Q5T9N1 xref: UniProtKB:Q7KZ68 xref: UniProtKB:Q7Z5E0 xref: UniProtKB:Q7Z5E1 xref: UniProtKB:Q7Z6M9 xref: UniProtKB:Q86X82 xref: UniProtKB:Q96Q89 xref: UniProtKB:Q9H3R8 xref: UniProtKB:Q9H6Q9 xref: UniProtKB:Q9H755 xref: UniProtKB:Q9NTC1 xref: UniProtKB:Q9UFR5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005123 ! MPHOSPH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000099 ! regulation of mitosis relationship: transforms_into CCO:B0013001 ! MPPH1_HUMAN-Phosphoserine303 relationship: transforms_into CCO:B0013002 ! MPPH1_HUMAN-Phosphoserine310 relationship: transforms_into CCO:B0013003 ! MPPH1_HUMAN-Phosphoserine321 relationship: transforms_into CCO:B0013004 ! MPPH1_HUMAN-Phosphoserine323 relationship: transforms_into CCO:B0013005 ! MPPH1_HUMAN-Phosphoserine488 relationship: transforms_into CCO:B0013006 ! MPPH1_HUMAN-Phosphoserine999 relationship: transforms_into CCO:B0013007 ! MPPH1_HUMAN-Phosphoserine1071 relationship: transforms_into CCO:B0013008 ! MPPH1_HUMAN-Phosphoserine1072 relationship: transforms_into CCO:B0013009 ! MPPH1_HUMAN-Phosphothreonine1644 [Term] id: CCO:B0002057 name: Q96Q97_HUMAN def: "Bradeion alpha" [UniProtKB:Q96Q97] xref: EMBL:BAB70694.1 xref: UniProtKB:Q96Q97 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006042 ! CE5B3 alpha_human relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002058 name: SPAG5_HUMAN def: "Sperm-associated antigen 5" [UniProtKB:Q96R06] synonym: "Astrin" EXACT [UniProtKB:Q96R06] synonym: "Deepest" EXACT [UniProtKB:Q96R06] synonym: "MAP126" EXACT [UniProtKB:Q96R06] synonym: "Mitotic spindle-associated protein p126" EXACT [UniProtKB:Q96R06] xref: EMBL:AAD02813.1 xref: EMBL:AAH00322.1 xref: EMBL:AAK91712.1 xref: EMBL:AAL06396.2 xref: EMBL:CAB59275.1 xref: EMBL:CAB70827.1 xref: UniProtKB:O95213 xref: UniProtKB:Q96R06 xref: UniProtKB:Q9BWE8 xref: UniProtKB:Q9NT17 xref: UniProtKB:Q9UFE6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005652 ! SPAG5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007618 ! atn1-spag5 physical interaction relationship: participates_in CCO:I0008321 ! snapap-spag5 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014158 ! SPAG5_HUMAN-Phosphoserine12 relationship: transforms_into CCO:B0014159 ! SPAG5_HUMAN-Phosphoserine14 relationship: transforms_into CCO:B0014160 ! SPAG5_HUMAN-Phosphoserine62 relationship: transforms_into CCO:B0014161 ! SPAG5_HUMAN-Phosphoserine66 relationship: transforms_into CCO:B0014162 ! SPAG5_HUMAN-Phosphothreonine111 relationship: transforms_into CCO:B0014163 ! SPAG5_HUMAN-Phosphoserine135 relationship: transforms_into CCO:B0014164 ! SPAG5_HUMAN-Phosphoserine249 relationship: transforms_into CCO:B0014165 ! SPAG5_HUMAN-Phosphoserine334 relationship: transforms_into CCO:B0014166 ! SPAG5_HUMAN-Phosphoserine341 relationship: transforms_into CCO:B0014167 ! SPAG5_HUMAN-Phosphoserine353 relationship: transforms_into CCO:B0014168 ! SPAG5_HUMAN-Phosphoserine362 relationship: transforms_into CCO:B0014169 ! SPAG5_HUMAN-Phosphoserine364 relationship: transforms_into CCO:B0014170 ! SPAG5_HUMAN-Phosphothreonine377 relationship: transforms_into CCO:B0014171 ! SPAG5_HUMAN-Phosphothreonine389 relationship: transforms_into CCO:B0014172 ! SPAG5_HUMAN-Phosphoserine401 relationship: transforms_into CCO:B0014173 ! SPAG5_HUMAN-Phosphothreonine937 [Term] id: CCO:B0002059 name: LAP2_HUMAN def: "Protein LAP2" [UniProtKB:Q96RT1] synonym: "Densin-180-like protein" EXACT [UniProtKB:Q96RT1] synonym: "Erbb2-interacting protein" EXACT [UniProtKB:Q96RT1] synonym: "Erbin" EXACT [UniProtKB:Q96RT1] xref: EMBL:AAF77048.1 xref: EMBL:AAH50692.1 xref: EMBL:AAK69431.1 xref: EMBL:BAA86539.2 xref: EMBL:BAA91538.1 xref: UniProtKB:Q86W38 xref: UniProtKB:Q96RT1 xref: UniProtKB:Q9NR18 xref: UniProtKB:Q9NW48 xref: UniProtKB:Q9ULJ5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004970 ! ERBB2IP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006766 ! shoc2-erbb2ip-2 physical interaction relationship: participates_in CCO:I0007382 ! shoc2-erbb2ip physical interaction relationship: participates_in CCO:I0007383 ! shoc2-erbb2ip-3 physical interaction relationship: participates_in CCO:I0007466 ! shoc2-erbb2ip-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012659 ! LAP2_HUMAN-Phosphoserine440 relationship: transforms_into CCO:B0012660 ! LAP2_HUMAN-Phosphotyrosine483 relationship: transforms_into CCO:B0012661 ! LAP2_HUMAN-Phosphothreonine485 relationship: transforms_into CCO:B0012662 ! LAP2_HUMAN-Phosphotyrosine487 relationship: transforms_into CCO:B0012663 ! LAP2_HUMAN-Phosphoserine598 relationship: transforms_into CCO:B0012664 ! LAP2_HUMAN-Phosphoserine602 relationship: transforms_into CCO:B0012665 ! LAP2_HUMAN-Phosphoserine603 relationship: transforms_into CCO:B0012666 ! LAP2_HUMAN-Phosphotyrosine733 relationship: transforms_into CCO:B0012667 ! LAP2_HUMAN-Phosphothreonine853 relationship: transforms_into CCO:B0012668 ! LAP2_HUMAN-Phosphoserine857 relationship: transforms_into CCO:B0012669 ! LAP2_HUMAN-Phosphothreonine917 relationship: transforms_into CCO:B0012670 ! LAP2_HUMAN-Phosphotyrosine920 relationship: transforms_into CCO:B0012671 ! LAP2_HUMAN-Phosphotyrosine972 relationship: transforms_into CCO:B0012672 ! LAP2_HUMAN-Phosphotyrosine981 relationship: transforms_into CCO:B0012673 ! LAP2_HUMAN-Phosphotyrosine1104 relationship: transforms_into CCO:B0012674 ! LAP2_HUMAN-Phosphotyrosine1107 relationship: transforms_into CCO:B0012675 ! LAP2_HUMAN-Phosphotyrosine1132 relationship: transforms_into CCO:B0012676 ! LAP2_HUMAN-Phosphoserine1271 [Term] id: CCO:B0002060 name: NEB2_HUMAN def: "Neurabin-2" [UniProtKB:Q96SB3] synonym: "Neurabin-II" EXACT [UniProtKB:Q96SB3] synonym: "Protein phosphatase 1 regulatory subunit 9B" EXACT [UniProtKB:Q96SB3] synonym: "Spinophilin" EXACT [UniProtKB:Q96SB3] xref: EMBL:CAC37685.1 xref: EMBL:CAD28455.2 xref: UniProtKB:Q8TCR9 xref: UniProtKB:Q96SB3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005171 ! PPP1R9B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006401 ! aah62584-q96sb3 physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis relationship: transforms_into CCO:B0013139 ! NEB2_HUMAN-Phosphoserine15 relationship: transforms_into CCO:B0013140 ! NEB2_HUMAN-Phosphoserine17 relationship: transforms_into CCO:B0013141 ! NEB2_HUMAN-Phosphoserine94 relationship: transforms_into CCO:B0013142 ! NEB2_HUMAN-Phosphoserine100 relationship: transforms_into CCO:B0013143 ! NEB2_HUMAN-Phosphoserine116 relationship: transforms_into CCO:B0013144 ! NEB2_HUMAN-Phosphoserine203 [Term] id: CCO:B0002062 name: CK5P1_HUMAN def: "CDK5 regulatory subunit-associated protein 1" [UniProtKB:Q96SZ6] synonym: "CDK5 activator-binding protein C42" EXACT [UniProtKB:Q96SZ6] xref: EMBL:AAD34147.1 xref: EMBL:AAF29131.1 xref: EMBL:AAH01215.1 xref: EMBL:AAH50706.1 xref: EMBL:BAB14760.1 xref: EMBL:BAB55120.1 xref: EMBL:CAI19393.1 xref: UniProtKB:Q5QP47 xref: UniProtKB:Q96SZ6 xref: UniProtKB:Q9BVG6 xref: UniProtKB:Q9BWZ5 xref: UniProtKB:Q9H859 xref: UniProtKB:Q9NZZ9 xref: UniProtKB:Q9Y3F0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004358 ! CDK5RAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006482 ! exosc5-cdk5rap1 physical interaction relationship: participates_in CCO:I0006484 ! exosc3-cdk5rap1 physical interaction relationship: participates_in CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity [Term] id: CCO:B0002063 name: UHRF1_HUMAN def: "E3 ubiquitin-protein ligase UHRF1" [UniProtKB:Q96T88] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q96T88] synonym: "HuNp95" EXACT [UniProtKB:Q96T88] synonym: "Inverted CCAAT box-binding protein of 90 kDa" EXACT [UniProtKB:Q96T88] synonym: "Nuclear protein 95" EXACT [UniProtKB:Q96T88] synonym: "Nuclear zinc finger protein Np95" EXACT [UniProtKB:Q96T88] synonym: "RING finger protein 106" EXACT [UniProtKB:Q96T88] synonym: "Transcription factor ICBP90" EXACT [UniProtKB:Q96T88] synonym: "Ubiquitin-like PHD and RING finger domain-containing protein 1" EXACT [UniProtKB:Q96T88] synonym: "Ubiquitin-like-containing PHD and RING finger domains protein 1" EXACT [UniProtKB:Q96T88] xref: EMBL:AAF28469.1 xref: EMBL:AAF64067.1 xref: EMBL:AAK55744.1 xref: EMBL:AAV40831.1 xref: EMBL:BAB15177.1 xref: EMBL:BAC20576.1 xref: UniProtKB:Q8J022 xref: UniProtKB:Q96T88 xref: UniProtKB:Q9H6S6 xref: UniProtKB:Q9P115 xref: UniProtKB:Q9P1U7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005879 ! UHRF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014577 ! UHRF1_HUMAN-Phosphoserine287 relationship: transforms_into CCO:B0014578 ! UHRF1_HUMAN-Phosphoserine298 relationship: transforms_into CCO:B0014579 ! UHRF1_HUMAN-Phosphoserine639 [Term] id: CCO:B0002064 name: GML_HUMAN def: "Glycosyl-phosphatidylinositol-anchored molecule-like protein precursor" [UniProtKB:Q99445] xref: EMBL:AAH74930.1 xref: EMBL:AAI26337.1 xref: EMBL:AAI26339.1 xref: EMBL:BAA12300.1 xref: EMBL:BAA19961.1 xref: UniProtKB:A0AVF6 xref: UniProtKB:O00686 xref: UniProtKB:O00731 xref: UniProtKB:Q99445 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004707 ! GML_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000900 ! extrinsic to membrane relationship: located_in CCO:C0001149 ! anchored to membrane relationship: participates_in CCO:P0000065 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [Term] id: CCO:B0002065 name: CDC5L_HUMAN def: "Cell division cycle 5-like protein" [UniProtKB:Q99459] synonym: "Cdc5-like protein" EXACT [UniProtKB:Q99459] synonym: "Pombe cdc5-related protein" EXACT [UniProtKB:Q99459] xref: EMBL:AAB61210.1 xref: EMBL:AAH01568.1 xref: EMBL:AAR89913.1 xref: EMBL:BAA20885.1 xref: EMBL:BAA24862.2 xref: EMBL:CAI20149.1 xref: EMBL:CAI40750.1 xref: UniProtKB:Q76N46 xref: UniProtKB:Q99459 xref: UniProtKB:Q99974 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004291 ! CDC5L_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000308 ! RNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000283 ! spliceosome relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000820 ! nuclear speck relationship: participates_in CCO:I0006076 ! orc1l-hscdc5 direct interaction relationship: participates_in CCO:I0006094 ! mcm3-hscdc5 direct interaction relationship: participates_in CCO:I0006097 ! orc2l-hscdc5 direct interaction relationship: participates_in CCO:I0006099 ! mcm4-hscdc5 direct interaction relationship: participates_in CCO:I0006101 ! mcm10-hscdc5 direct interaction relationship: participates_in CCO:I0006147 ! cdkn1a-hscdc5 direct interaction relationship: participates_in CCO:I0006568 ! cdc5l-akap9 physical interaction relationship: participates_in CCO:I0006569 ! cdc5l-aof2 physical interaction relationship: participates_in CCO:I0006572 ! disc1-cdc5l physical interaction relationship: participates_in CCO:I0006573 ! disc1-cdc5l-1 physical interaction relationship: participates_in CCO:I0006577 ! cdc5l-crnkl1 physical interaction relationship: participates_in CCO:I0006582 ! cdc5l-hook1 physical interaction relationship: participates_in CCO:I0006583 ! cdc5l-kiaa0182 physical interaction relationship: participates_in CCO:I0006584 ! cdc5l-kiaa0240 physical interaction relationship: participates_in CCO:I0006585 ! cdc5l-znf451 physical interaction relationship: participates_in CCO:I0006586 ! cdc5l-kif3c physical interaction relationship: participates_in CCO:I0006587 ! cdc5l-kif5b physical interaction relationship: participates_in CCO:I0006588 ! cdc5l-kiaa1267 physical interaction relationship: participates_in CCO:I0006595 ! cdc5l-myt1l physical interaction relationship: participates_in CCO:I0006598 ! cdc5l-ppfia2 physical interaction relationship: participates_in CCO:I0006599 ! cdc5l-ppp1r13b physical interaction relationship: participates_in CCO:I0006603 ! cdc5l-sptbn1 physical interaction relationship: participates_in CCO:I0006605 ! cdc5l-ywhaz physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011084 ! CDC5L_HUMAN-Phosphoserine303 relationship: transforms_into CCO:B0011085 ! CDC5L_HUMAN-Phosphothreonine385 relationship: transforms_into CCO:B0011086 ! CDC5L_HUMAN-Phosphothreonine396 [Term] id: CCO:B0002066 name: PSMD1_HUMAN def: "26S proteasome non-ATPase regulatory subunit 1" [UniProtKB:Q99460] synonym: "26S proteasome regulatory subunit RPN2" EXACT [UniProtKB:Q99460] synonym: "26S proteasome regulatory subunit S1" EXACT [UniProtKB:Q99460] synonym: "26S proteasome subunit p112" EXACT [UniProtKB:Q99460] xref: EMBL:AAH01053.1 xref: EMBL:AAH14013.1 xref: EMBL:AAH39845.1 xref: EMBL:AAH47897.1 xref: EMBL:AAH64398.1 xref: EMBL:AAH73833.1 xref: EMBL:AAH94720.1 xref: EMBL:AAI12345.1 xref: EMBL:AAI14435.1 xref: EMBL:AAX93127.1 xref: EMBL:BAA07918.1 xref: UniProtKB:Q24JU0 xref: UniProtKB:Q53TI2 xref: UniProtKB:Q6GMU5 xref: UniProtKB:Q6P2P4 xref: UniProtKB:Q6PJM7 xref: UniProtKB:Q6PKG9 xref: UniProtKB:Q86VU1 xref: UniProtKB:Q8IV79 xref: UniProtKB:Q99460 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005390 ! PSMD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006428 ! traf6-psmd1 physical interaction relationship: participates_in CCO:I0006537 ! hspcb-aars physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0013627 ! PSMD1_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0013628 ! PSMD1_HUMAN-Phosphotyrosine49 relationship: transforms_into CCO:B0013629 ! PSMD1_HUMAN-Phosphothreonine273 relationship: transforms_into CCO:B0013630 ! PSMD1_HUMAN-Phosphothreonine311 relationship: transforms_into CCO:B0013631 ! PSMD1_HUMAN-Phosphoserine315 [Term] id: CCO:B0002067 name: GA2L1_HUMAN def: "GAS2-like protein 1" [UniProtKB:Q99501] synonym: "GAS2-related protein on chromosome 22" EXACT [UniProtKB:Q99501] synonym: "Growth arrest-specific protein 2-like 1" EXACT [UniProtKB:Q99501] xref: EMBL:AAH01782.1 xref: EMBL:AAH07624.1 xref: EMBL:AAH11047.1 xref: EMBL:BAD97322.1 xref: EMBL:CAA69174.1 xref: EMBL:CAA69176.1 xref: UniProtKB:Q53EN7 xref: UniProtKB:Q92640 xref: UniProtKB:Q99501 xref: UniProtKB:Q9BUY9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004671 ! GAS2L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0011916 ! GA2L1_HUMAN-Phosphoserine384 relationship: transforms_into CCO:B0041137 ! GA2L1_HUMAN-Phosphoserine306 relationship: transforms_into CCO:B0041138 ! GA2L1_HUMAN-Phosphoserine352 [Term] id: CCO:B0002068 name: Q99539_HUMAN def: "X-1 protein" [UniProtKB:Q99539] xref: EMBL:CAA66919.1 xref: UniProtKB:Q99539 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006044 ! X-1_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000487 ! ATP-dependent DNA helicase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003433 ! ligase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:P0000039 ! M phase [Term] id: CCO:B0002069 name: Q99540_HUMAN def: "Ligase-like protein" [UniProtKB:Q99540] xref: EMBL:CAA66920.1 xref: UniProtKB:Q99540 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000415 ! DNA ligase (NAD+) activity relationship: has_function CCO:F0003433 ! ligase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:P0000039 ! M phase [Term] id: CCO:B0002070 name: ZWIA_HUMAN def: "Putative ZW10 interactor antisense gene protein" [UniProtKB:Q99546] synonym: "M-phase phosphoprotein 5" EXACT [UniProtKB:Q99546] xref: EMBL:CAA66914.1 xref: UniProtKB:Q99546 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005974 ! ZWINTAS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014765 ! ZWIA_HUMAN-Phosphothreonine51 relationship: transforms_into CCO:B0014766 ! ZWIA_HUMAN-Phosphoserine65 relationship: transforms_into CCO:B0014767 ! ZWIA_HUMAN-Phosphoserine78 relationship: transforms_into CCO:B0014768 ! ZWIA_HUMAN-Phosphoserine92 [Term] id: CCO:B0002071 name: MPH6_HUMAN def: "M-phase phosphoprotein 6" [UniProtKB:Q99547] xref: EMBL:AAH05242.1 xref: EMBL:AAH11020.1 xref: EMBL:AAH31017.1 xref: EMBL:CAA66916.1 xref: UniProtKB:Q99547 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005116 ! MPHOSPH6_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0006012 ! mphosph6-kiaa0052 physical interaction relationship: participates_in CCO:I0006013 ! mphosph6-parn physical interaction relationship: participates_in CCO:I0006014 ! mphosph6-pmscl2 physical interaction relationship: participates_in CCO:I0006485 ! mphosph6-eif3s4 physical interaction relationship: participates_in CCO:I0006486 ! mphosph6-snx9 physical interaction relationship: participates_in CCO:I0006487 ! mphosph6-thop1 physical interaction relationship: participates_in CCO:I0006488 ! mphosph6-q9y448 physical interaction relationship: participates_in CCO:I0006489 ! mphosph6-dncl2a physical interaction relationship: participates_in CCO:I0006490 ! mphosph6-rps20 physical interaction relationship: participates_in CCO:I0006491 ! mphosph6-dnm2 physical interaction relationship: participates_in CCO:I0006492 ! mphosph6-ded physical interaction relationship: participates_in CCO:I0006493 ! mphosph6-dkfzp762i16 physical interaction relationship: participates_in CCO:I0008022 ! mphosph6-tle1 physical interaction relationship: participates_in CCO:I0008023 ! mphosph6-tp53 physical interaction relationship: participates_in CCO:I0008134 ! mphosph6-rif1 physical interaction relationship: participates_in CCO:I0008135 ! mphosph6-unc119 physical interaction relationship: participates_in CCO:I0008136 ! mphosph6-zhx1 physical interaction relationship: participates_in CCO:I0008272 ! mphosph6-aplp1 physical interaction relationship: participates_in CCO:I0008273 ! mphosph6-dkfzp564o05 physical interaction relationship: participates_in CCO:I0008274 ! mphosph6-gdf9 physical interaction relationship: participates_in CCO:I0008409 ! mphosph6-c14orf1 physical interaction relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle relationship: transforms_into CCO:B0012982 ! MPH6_HUMAN-Phosphothreonine147 [Term] id: CCO:B0002072 name: MPP8_HUMAN def: "M-phase phosphoprotein 8" [UniProtKB:Q99549] synonym: "Twa3" EXACT [UniProtKB:Q99549] synonym: "Two hybrid-associated protein 3 with RanBPM" EXACT [UniProtKB:Q99549] xref: EMBL:AAH03542.2 xref: EMBL:AAH46214.1 xref: EMBL:BAB71284.1 xref: EMBL:CAA66912.1 xref: EMBL:CAI16671.1 xref: EMBL:CAI41002.1 xref: EMBL:CAI46172.1 xref: EMBL:EAX08230.1 xref: UniProtKB:Q5JPE5 xref: UniProtKB:Q5JTQ0 xref: UniProtKB:Q86TK3 xref: UniProtKB:Q96MK4 xref: UniProtKB:Q99549 xref: UniProtKB:Q9BTP1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005121 ! MPHOSPH8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012991 ! MPP8_HUMAN-Phosphoserine51 relationship: transforms_into CCO:B0012992 ! MPP8_HUMAN-Phosphoserine136 relationship: transforms_into CCO:B0012993 ! MPP8_HUMAN-Phosphoserine138 relationship: transforms_into CCO:B0012994 ! MPP8_HUMAN-Phosphoserine164 relationship: transforms_into CCO:B0012995 ! MPP8_HUMAN-Phosphoserine272 relationship: transforms_into CCO:B0012996 ! MPP8_HUMAN-Phosphoserine319 relationship: transforms_into CCO:B0012997 ! MPP8_HUMAN-Phosphothreonine334 relationship: transforms_into CCO:B0012998 ! MPP8_HUMAN-Phosphothreonine385 relationship: transforms_into CCO:B0012999 ! MPP8_HUMAN-Phosphoserine392 relationship: transforms_into CCO:B0013000 ! MPP8_HUMAN-Phosphothreonine454 [Term] id: CCO:B0002076 name: CDCA3_HUMAN def: "Cell division cycle-associated protein 3" [UniProtKB:Q99618] synonym: "Gene-rich cluster protein C8" EXACT [UniProtKB:Q99618] synonym: "TOME-1" EXACT [UniProtKB:Q99618] synonym: "Trigger of mitotic entry protein 1" EXACT [UniProtKB:Q99618] xref: EMBL:AAB51327.1 xref: EMBL:AAH02551.1 xref: EMBL:AAH36512.1 xref: UniProtKB:Q99618 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004296 ! CDCA3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005721 ! cdca3-traf2 physical interaction relationship: participates_in CCO:I0005917 ! cdca3-ctdsp1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011092 ! CDCA3_HUMAN-Phosphoserine68 relationship: transforms_into CCO:B0011093 ! CDCA3_HUMAN-Phosphothreonine159 relationship: transforms_into CCO:B0011094 ! CDCA3_HUMAN-Phosphoserine165 relationship: transforms_into CCO:B0011095 ! CDCA3_HUMAN-Phosphothreonine177 relationship: transforms_into CCO:B0011096 ! CDCA3_HUMAN-Phosphoserine199 relationship: transforms_into CCO:B0011097 ! CDCA3_HUMAN-Phosphoserine209 [Term] id: CCO:B0002077 name: RAD9A_HUMAN def: "Cell cycle checkpoint control protein RAD9A" [UniProtKB:Q99638] synonym: "DNA repair exonuclease rad9 homolog A" EXACT [UniProtKB:Q99638] synonym: "EC 3.1.11.2" EXACT [UniProtKB:Q99638] synonym: "hRAD9" EXACT [UniProtKB:Q99638] xref: EMBL:AAB39928.1 xref: EMBL:AAH14848.1 xref: EMBL:AAU89725.1 xref: EMBL:CAG38746.1 xref: UniProtKB:Q6FI29 xref: UniProtKB:Q96C41 xref: UniProtKB:Q99638 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005419 ! RAD9A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000007 ! DNA replication checkpoint relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: transforms_into CCO:B0013671 ! RAD9A_HUMAN-Phosphotyrosine28 relationship: transforms_into CCO:B0013672 ! RAD9A_HUMAN-Phosphoserine272 relationship: transforms_into CCO:B0013673 ! RAD9A_HUMAN-Phosphoserine277 relationship: transforms_into CCO:B0013674 ! RAD9A_HUMAN-Phosphoserine328 relationship: transforms_into CCO:B0013675 ! RAD9A_HUMAN-Phosphoserine341 relationship: transforms_into CCO:B0013676 ! RAD9A_HUMAN-Phosphoserine375 relationship: transforms_into CCO:B0013677 ! RAD9A_HUMAN-Phosphoserine380 relationship: transforms_into CCO:B0013678 ! RAD9A_HUMAN-Phosphoserine387 [Term] id: CCO:B0002078 name: PMYT1_HUMAN def: "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase" [UniProtKB:Q99640] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q99640] synonym: "Myt1 kinase" EXACT [UniProtKB:Q99640] xref: EMBL:AAB71843.1 xref: EMBL:AAC04477.1 xref: EMBL:AAC04478.1 xref: EMBL:AAC50949.1 xref: EMBL:AAN40703.1 xref: EMBL:CAD28540.1 xref: UniProtKB:O14731 xref: UniProtKB:Q7LE24 xref: UniProtKB:Q8TCM9 xref: UniProtKB:Q99640 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005347 ! PKMYT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006959 ! pkmyt1-cdc2-1 phosphorylation relationship: participates_in CCO:I0007087 ! pkmyt1-cdc2-2 phosphorylation relationship: participates_in CCO:I0007244 ! pkmyt1-ccnb1-1 physical interaction relationship: participates_in CCO:I0007245 ! ccnb1-pkmyt1-1 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000099 ! regulation of mitosis relationship: transforms_into CCO:B0013588 ! PMYT1_HUMAN-Phosphoserine94 relationship: transforms_into CCO:B0013589 ! PMYT1_HUMAN-Phosphoserine143 relationship: transforms_into CCO:B0013590 ! PMYT1_HUMAN-Phosphoserine426 relationship: transforms_into CCO:B0013591 ! PMYT1_HUMAN-Phosphothreonine495 [Term] id: CCO:B0002079 name: Q99648_HUMAN def: "Septin" [UniProtKB:Q99648] xref: EMBL:AAC39780.1 xref: UniProtKB:Q99648 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005588 ! SEPT5_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000522 ! synaptic vesicle relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002080 name: KIF2C_HUMAN def: "Kinesin-like protein KIF2C" [UniProtKB:Q99661] synonym: "Kinesin-like protein 6" EXACT [UniProtKB:Q99661] synonym: "MCAK" EXACT [UniProtKB:Q99661] synonym: "Mitotic centromere-associated kinesin" EXACT [UniProtKB:Q99661] xref: EMBL:AAC27660.1 xref: EMBL:AAH08764.1 xref: EMBL:AAH14924.1 xref: EMBL:AAK20168.1 xref: UniProtKB:Q96C18 xref: UniProtKB:Q96HB8 xref: UniProtKB:Q99661 xref: UniProtKB:Q9BWV8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004947 ! KIF2C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012603 ! KIF2C_HUMAN-Phosphoserine628 relationship: transforms_into CCO:B0012604 ! KIF2C_HUMAN-Phosphoserine629 relationship: transforms_into CCO:B0012605 ! KIF2C_HUMAN-Phosphoserine632 relationship: transforms_into CCO:B0012606 ! KIF2C_HUMAN-Phosphoserine633 [Term] id: CCO:B0002081 name: CGRE1_HUMAN def: "Cell growth regulator with EF hand domain protein 1" [UniProtKB:Q99674] synonym: "Cell growth regulatory gene 11 protein" EXACT [UniProtKB:Q99674] xref: EMBL:AAC50896.1 xref: UniProtKB:Q99674 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004339 ! CGREF1_human relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002082 name: CGRF1_HUMAN def: "Cell growth regulator with RING finger domain protein 1" [UniProtKB:Q99675] synonym: "Cell growth regulatory gene 19 protein" EXACT [UniProtKB:Q99675] synonym: "RING finger protein 197" EXACT [UniProtKB:Q99675] xref: EMBL:AAC50897.1 xref: EMBL:AAH15063.1 xref: UniProtKB:Q96BX2 xref: UniProtKB:Q99675 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004340 ! CGRRF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002083 name: GFI1_HUMAN def: "Zinc finger protein Gfi-1" [UniProtKB:Q99684] synonym: "Growth factor independent protein 1" EXACT [UniProtKB:Q99684] synonym: "Zinc finger protein 163" EXACT [UniProtKB:Q99684] xref: EMBL:AAB37272.1 xref: EMBL:AAH32751.1 xref: EMBL:AAH74866.1 xref: EMBL:AAH74867.1 xref: UniProtKB:Q8N564 xref: UniProtKB:Q99684 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004695 ! GFI1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007629 ! gfi1-prkcabp physical interaction relationship: participates_in CCO:P0000013 ! G1/S-specific transcription in mitotic cell cycle [Term] id: CCO:B0002084 name: RBBP8_HUMAN def: "Retinoblastoma-binding protein 8" [UniProtKB:Q99708] synonym: "CtBP-interacting protein" EXACT [UniProtKB:Q99708] synonym: "CtIP" EXACT [UniProtKB:Q99708] synonym: "RBBP-8" EXACT [UniProtKB:Q99708] synonym: "Retinoblastoma-interacting protein and myosin-like" EXACT [UniProtKB:Q99708] synonym: "RIM" EXACT [UniProtKB:Q99708] xref: EMBL:AAC14371.1 xref: EMBL:AAC34368.1 xref: UniProtKB:O75371 xref: UniProtKB:Q99708 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005442 ! RBBP8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: transforms_into CCO:B0013747 ! RBBP8_HUMAN-Phosphoserine327 relationship: transforms_into CCO:B0013748 ! RBBP8_HUMAN-Phosphoserine664 relationship: transforms_into CCO:B0013749 ! RBBP8_HUMAN-Phosphoserine679 relationship: transforms_into CCO:B0013750 ! RBBP8_HUMAN-Phosphoserine745 [Term] id: CCO:B0002085 name: SEPT5_HUMAN def: "Septin-5" [UniProtKB:Q99719] synonym: "CDCrel-1" EXACT [UniProtKB:Q99719] synonym: "Cell division control-related protein 1" EXACT [UniProtKB:Q99719] synonym: "Peanut-like protein 1" EXACT [UniProtKB:Q99719] xref: EMBL:AAB93438.1 xref: EMBL:AAC39779.1 xref: EMBL:AAH25261.1 xref: EMBL:CAA72332.1 xref: EMBL:CAG30431.1 xref: UniProtKB:O15251 xref: UniProtKB:Q99719 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005588 ! SEPT5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006498 ! lsm8-sept5 physical interaction relationship: participates_in CCO:I0006897 ! sept5-sept11 physical interaction relationship: participates_in CCO:I0006898 ! sept5-sept8 physical interaction relationship: participates_in CCO:I0006899 ! sept11-sept5 physical interaction relationship: participates_in CCO:I0007372 ! sept5-sept11-1 physical interaction relationship: participates_in CCO:I0007373 ! sept5-sept8-1 physical interaction relationship: participates_in CCO:I0007376 ! sept11-sept5-1 physical interaction relationship: participates_in CCO:I0007794 ! sept5-sept11-2 direct interaction relationship: participates_in CCO:I0008151 ! sept5-pfn2 physical interaction relationship: participates_in CCO:I0008294 ! sept5-myst2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013996 ! SEPT5_HUMAN-Phosphoserine327 relationship: transforms_into CCO:B0013997 ! SEPT5_HUMAN-Phosphothreonine336 relationship: transforms_into CCO:B0041194 ! SEPT5_HUMAN-Phosphoserine225 [Term] id: CCO:B0002086 name: BARD1_HUMAN def: "BRCA1-associated RING domain protein 1" [UniProtKB:Q99728] synonym: "BARD-1" EXACT [UniProtKB:Q99728] xref: EMBL:AAB38316.1 xref: EMBL:AAB99978.1 xref: EMBL:AAI26427.1 xref: EMBL:AAX93130.1 xref: UniProtKB:O43574 xref: UniProtKB:Q53SS5 xref: UniProtKB:Q99728 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004138 ! BARD1_human relationship: has_function CCO:F0000308 ! RNA binding relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0004209 ! kinase binding relationship: has_function CCO:F0005714 ! protein homodimerization activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_function CCO:F0006299 ! protein heterodimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000026 ! ubiquitin ligase complex relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0001247 ! BRCA1-BARD1 complex relationship: participates_in CCO:I0006166 ! bard1-htatip physical interaction relationship: participates_in CCO:I0006167 ! bard1-zhx1 physical interaction relationship: participates_in CCO:I0006168 ! bard1-tcerg1-1 physical interaction relationship: participates_in CCO:I0006169 ! bard1-git1-1 physical interaction relationship: participates_in CCO:I0006170 ! bard1-ikbkap physical interaction relationship: participates_in CCO:I0006171 ! bard1-hbo1-1 physical interaction relationship: participates_in CCO:I0006172 ! bard1-bp465 physical interaction relationship: participates_in CCO:I0006173 ! bard1-kbtbd7 physical interaction relationship: participates_in CCO:I0006174 ! bard1-pias4 physical interaction relationship: participates_in CCO:I0006175 ! bard1-kiaa1377-1 physical interaction relationship: participates_in CCO:I0006176 ! bard1-setdb1 physical interaction relationship: participates_in CCO:I0006177 ! bard1-ptn physical interaction relationship: participates_in CCO:I0006178 ! bard1-gprasp2 physical interaction relationship: participates_in CCO:I0006179 ! bard1-fez1 physical interaction relationship: participates_in CCO:I0007078 ! bard1-git1 physical interaction relationship: participates_in CCO:I0007079 ! bard1-hbo1 physical interaction relationship: participates_in CCO:I0007080 ! bard1-kiaa1377 physical interaction relationship: participates_in CCO:I0007082 ! bard1-tcerg1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002087 name: CDC6_HUMAN def: "Cell division control protein 6 homolog" [UniProtKB:Q99741] synonym: "CDC6-related protein" EXACT [UniProtKB:Q99741] synonym: "HsCDC18" EXACT [UniProtKB:Q99741] synonym: "HsCDC6" EXACT [UniProtKB:Q99741] synonym: "p62(cdc6)" EXACT [UniProtKB:Q99741] xref: EMBL:AAB38317.1 xref: EMBL:AAC52071.1 xref: EMBL:AAH25232.1 xref: EMBL:AAN10296.1 xref: UniProtKB:Q8TB30 xref: UniProtKB:Q99741 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004292 ! CDC6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006075 ! orc1l-hscdc6 direct interaction relationship: participates_in CCO:I0006100 ! orc2l-hscdc6 direct interaction relationship: participates_in CCO:I0006104 ! mcm10-hscdc6 direct interaction relationship: participates_in CCO:I0006111 ! mcm2-hscdc6 direct interaction relationship: participates_in CCO:I0006122 ! hscdc6-orc5l direct interaction relationship: participates_in CCO:I0006123 ! orc3l-hscdc6 direct interaction relationship: participates_in CCO:I0006124 ! hscdc6-orc6l direct interaction relationship: participates_in CCO:I0006128 ! cdkn2a-hscdc6 direct interaction relationship: participates_in CCO:I0006136 ! cdkn1a-hscdc6 direct interaction relationship: participates_in CCO:I0006154 ! mcm3-hscdc6 direct interaction relationship: participates_in CCO:I0006613 ! cdc6-ubiq-1 physical interaction relationship: participates_in CCO:I0007239 ! cdt1-cdc6-1 physical interaction relationship: participates_in CCO:I0007240 ! cdt1-cdc6-2 physical interaction relationship: participates_in CCO:P0000007 ! DNA replication checkpoint relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000100 ! traversing start control point of mitotic cell cycle relationship: transforms_into CCO:B0011087 ! CDC6_HUMAN-Phosphothreonine166 [Term] id: CCO:B0002088 name: Q99773_HUMAN def: "Putative uncharacterized protein" [UniProtKB:Q99773] xref: EMBL:AAB50210.1 xref: UniProtKB:Q99773 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000388 ! spindle relationship: participates_in CCO:P0000300 ! centrosome duplication [Term] id: CCO:B0002090 name: SPI2A_HUMAN def: "Spindlin-2A" [UniProtKB:Q99865] synonym: "Protein DXF34" EXACT [UniProtKB:Q99865] synonym: "SPIN-2" EXACT [UniProtKB:Q99865] synonym: "SPIN-2A" EXACT [UniProtKB:Q99865] synonym: "Spindlin-like protein 2A" EXACT [UniProtKB:Q99865] xref: EMBL:AAH71694.1 xref: EMBL:CAA70988.1 xref: EMBL:CAI42597.1 xref: UniProtKB:O75650 xref: UniProtKB:Q6IPW2 xref: UniProtKB:Q99865 xref: UniProtKB:Q9UJJ0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005661 ! SPIN2A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002091 name: CITE2_HUMAN def: "Cbp/p300-interacting transactivator 2" [UniProtKB:Q99967] synonym: "MRG-1" EXACT [UniProtKB:Q99967] synonym: "MSG-related protein 1" EXACT [UniProtKB:Q99967] synonym: "P35srj" EXACT [UniProtKB:Q99967] xref: EMBL:AAC51114.1 xref: EMBL:AAD10055.1 xref: EMBL:AAF01263.1 xref: EMBL:AAF01264.1 xref: EMBL:AAH04377.1 xref: EMBL:CAH70354.1 xref: UniProtKB:O95426 xref: UniProtKB:Q5VTF4 xref: UniProtKB:Q99967 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004354 ! CITED2_human relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0004454 ! transcription regulator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0006724 ! p300-tfap2a-2 physical interaction relationship: participates_in CCO:I0006891 ! cited2-tfap2a-1 physical interaction relationship: participates_in CCO:I0006892 ! cited2-tfap2b-1 physical interaction relationship: participates_in CCO:I0006893 ! cited2-tfap2c-1 physical interaction relationship: participates_in CCO:I0007147 ! p300-cited2-1 physical interaction relationship: participates_in CCO:I0007417 ! p300-tfap2a-6 physical interaction relationship: participates_in CCO:I0007793 ! tfap2c-cited2-1 physical interaction relationship: participates_in CCO:P0000247 ! positive regulation of cell cycle [Term] id: CCO:B0002092 name: CND3_HUMAN def: "Condensin complex subunit 3" [UniProtKB:Q9BPX3] synonym: "Antigen NY-MEL-3" EXACT [UniProtKB:Q9BPX3] synonym: "Chromosome-associated protein G" EXACT [UniProtKB:Q9BPX3] synonym: "Condensin subunit CAP-G" EXACT [UniProtKB:Q9BPX3] synonym: "hCAP-G" EXACT [UniProtKB:Q9BPX3] synonym: "Non-SMC condensin I complex subunit G" EXACT [UniProtKB:Q9BPX3] synonym: "XCAP-G homolog" EXACT [UniProtKB:Q9BPX3] xref: EMBL:AAG30732.1 xref: EMBL:AAG49627.1 xref: EMBL:AAH00827.1 xref: EMBL:AAH02337.2 xref: EMBL:AAI01477.1 xref: EMBL:BAB14069.1 xref: EMBL:BAB14429.1 xref: EMBL:BAB21557.1 xref: EMBL:BAB55165.1 xref: UniProtKB:Q3MJE0 xref: UniProtKB:Q96SV9 xref: UniProtKB:Q9BPX3 xref: UniProtKB:Q9BUR3 xref: UniProtKB:Q9BVY1 xref: UniProtKB:Q9H914 xref: UniProtKB:Q9H9Z6 xref: UniProtKB:Q9HBI9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004378 ! NCAPG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006665 ! npm_alk-cdc14 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: transforms_into CCO:B0011304 ! CND3_HUMAN-Phosphoserine390 relationship: transforms_into CCO:B0011305 ! CND3_HUMAN-Phosphothreonine463 relationship: transforms_into CCO:B0011306 ! CND3_HUMAN-Phosphoserine467 relationship: transforms_into CCO:B0011307 ! CND3_HUMAN-Phosphoserine674 relationship: transforms_into CCO:B0011308 ! CND3_HUMAN-Phosphoserine944 relationship: transforms_into CCO:B0011309 ! CND3_HUMAN-Phosphoserine959 relationship: transforms_into CCO:B0011310 ! CND3_HUMAN-Phosphoserine973 relationship: transforms_into CCO:B0011311 ! CND3_HUMAN-Phosphoserine975 relationship: transforms_into CCO:B0011312 ! CND3_HUMAN-Phosphoserine1015 relationship: transforms_into CCO:B0041129 ! CND3_HUMAN-Phosphothreonine686 [Term] id: CCO:B0002093 name: SPI2B_HUMAN def: "Spindlin-2B" [UniProtKB:Q9BPZ2] synonym: "SPIN-2" EXACT [UniProtKB:Q9BPZ2] synonym: "SPIN-2B" EXACT [UniProtKB:Q9BPZ2] synonym: "Spindlin-like protein 2B" EXACT [UniProtKB:Q9BPZ2] xref: EMBL:AAH00044.1 xref: EMBL:AAH71974.1 xref: EMBL:AAK37566.1 xref: EMBL:CAI42600.1 xref: UniProtKB:Q7Z2M0 xref: UniProtKB:Q9BPZ2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005662 ! SPIN2B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002094 name: LZTS2_HUMAN def: "Leucine zipper putative tumor suppressor 2" [UniProtKB:Q9BRK4] synonym: "Protein LAPSER1" EXACT [UniProtKB:Q9BRK4] xref: EMBL:AAH06212.2 xref: EMBL:AAH58938.1 xref: EMBL:AAK31577.1 xref: EMBL:BAB47442.1 xref: EMBL:CAD39005.1 xref: UniProtKB:Q8N3I0 xref: UniProtKB:Q96J79 xref: UniProtKB:Q96JL2 xref: UniProtKB:Q9BRK4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005001 ! LZTS2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000766 ! membrane relationship: participates_in CCO:I0005730 ! lzts2-rbpms physical interaction relationship: participates_in CCO:I0005750 ! lzts2-pak7 physical interaction relationship: participates_in CCO:I0005774 ! lzts2-znf581 physical interaction relationship: participates_in CCO:I0005816 ! lzts2-trim29 physical interaction relationship: participates_in CCO:I0005864 ! lzts2-pepp2 physical interaction relationship: participates_in CCO:I0005878 ! lzts2-traf2 physical interaction relationship: participates_in CCO:I0006644 ! lzts2-a2bp1 physical interaction relationship: participates_in CCO:I0007658 ! gfi1b-lzts2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002095 name: APC13_HUMAN def: "Anaphase-promoting complex subunit 13" [UniProtKB:Q9BS18] synonym: "APC13" EXACT [UniProtKB:Q9BS18] synonym: "Cylosome subunit 13" EXACT [UniProtKB:Q9BS18] xref: EMBL:AAH05398.1 xref: EMBL:CAB43251.1 xref: UniProtKB:Q9BS18 xref: UniProtKB:Q9Y3V0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004053 ! ANAPC13_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002096 name: Q9BSP9_HUMAN def: "DST protein" [UniProtKB:Q9BSP9] xref: EMBL:AAH04912.2 xref: UniProtKB:Q9BSP9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004183 ! DST_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002097 name: CABL2_HUMAN def: "CDK5 and ABL1 enzyme substrate 2" [UniProtKB:Q9BTV7] synonym: "Ik3-2" EXACT [UniProtKB:Q9BTV7] synonym: "Interactor with CDK3 2" EXACT [UniProtKB:Q9BTV7] xref: EMBL:AAH03122.1 xref: EMBL:CAI23283.2 xref: UniProtKB:Q5JWL0 xref: UniProtKB:Q9BTV7 xref: UniProtKB:Q9BYK0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004204 ! CABLES2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000346 ! regulation of cell cycle [Term] id: CCO:B0002098 name: HTAI2_HUMAN def: "Oxidoreductase HTATIP2" [UniProtKB:Q9BUP3] synonym: "30 kDa HIV-1 TAT-interacting protein" EXACT [UniProtKB:Q9BUP3] synonym: "EC 1.1.1.-" EXACT [UniProtKB:Q9BUP3] synonym: "HIV-1 TAT-interactive protein 2" EXACT [UniProtKB:Q9BUP3] xref: EMBL:AAB84360.1 xref: EMBL:AAC39694.1 xref: EMBL:AAC78331.1 xref: EMBL:AAH02439.1 xref: EMBL:AAH15358.1 xref: EMBL:BAD96689.1 xref: EMBL:BAD96730.1 xref: EMBL:CAG33102.1 xref: UniProtKB:O15383 xref: UniProtKB:O60520 xref: UniProtKB:O95345 xref: UniProtKB:Q53GC1 xref: UniProtKB:Q53GG2 xref: UniProtKB:Q6IBI3 xref: UniProtKB:Q9BUP3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004842 ! HTATIP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0012286 ! HTAI2_HUMAN-Phosphoserine45 [Term] id: CCO:B0002099 name: CP250_HUMAN def: "Centrosome-associated protein CEP250" [UniProtKB:Q9BV73] synonym: "C-Nap1" EXACT [UniProtKB:Q9BV73] synonym: "Centrosomal Nek2-associated protein 1" EXACT [UniProtKB:Q9BV73] synonym: "Centrosomal protein 2" EXACT [UniProtKB:Q9BV73] xref: EMBL:AAC06349.1 xref: EMBL:AAC07988.1 xref: EMBL:AAH01433.1 xref: EMBL:CAB89415.1 xref: UniProtKB:O14812 xref: UniProtKB:O60588 xref: UniProtKB:Q9BV73 xref: UniProtKB:Q9H450 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004389 ! CEP250_human relationship: has_function CCO:F0004210 ! protein kinase binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000385 ! microtubule organizing center relationship: located_in CCO:C0000481 ! cilium relationship: located_in CCO:C0001706 ! cell projection relationship: participates_in CCO:P0000038 ! mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000167 ! regulation of centriole-centriole cohesion [Term] id: CCO:B0002100 name: KTNB1_HUMAN def: "Katanin p80 WD40-containing subunit B1" [UniProtKB:Q9BVA0] synonym: "Katanin p80 subunit B1" EXACT [UniProtKB:Q9BVA0] synonym: "p80 katanin" EXACT [UniProtKB:Q9BVA0] xref: EMBL:AAC09328.1 xref: EMBL:AAH01353.1 xref: EMBL:AAP35668.1 xref: EMBL:CAG33043.1 xref: EMBL:EAW82951.1 xref: UniProtKB:A6NCG6 xref: UniProtKB:O60620 xref: UniProtKB:Q9BVA0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004964 ! KATNB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012647 ! KTNB1_HUMAN-Phosphothreonine395 [Term] id: CCO:B0002103 name: GNL3_HUMAN def: "Guanine nucleotide-binding protein-like 3" [UniProtKB:Q9BVP2] synonym: "E2-induced gene 3 protein" EXACT [UniProtKB:Q9BVP2] synonym: "NNP47" EXACT [UniProtKB:Q9BVP2] synonym: "Novel nucleolar protein 47" EXACT [UniProtKB:Q9BVP2] synonym: "Nucleolar GTP-binding protein 3" EXACT [UniProtKB:Q9BVP2] synonym: "Nucleostemin" EXACT [UniProtKB:Q9BVP2] xref: EMBL:AAF09482.1 xref: EMBL:AAH01024.1 xref: EMBL:BAB55168.1 xref: EMBL:BAB55169.1 xref: UniProtKB:Q96SV6 xref: UniProtKB:Q96SV7 xref: UniProtKB:Q9BVP2 xref: UniProtKB:Q9UJY0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004712 ! GNL3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006980 ! gnl3-p53 physical interaction [Term] id: CCO:B0002104 name: TIPIN_HUMAN def: "TIMELESS-interacting protein" [UniProtKB:Q9BVW5] xref: EMBL:AAH00870.1 xref: EMBL:BAA91229.1 xref: EMBL:DAA01365.1 xref: EMBL:EAW77762.1 xref: UniProtKB:Q9BVW5 xref: UniProtKB:Q9NWZ6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005785 ! TIPIN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000007 ! DNA replication checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000186 ! intra-S DNA damage checkpoint relationship: participates_in CCO:P0000215 ! regulation of S phase relationship: participates_in CCO:P0000216 ! regulation of DNA replication during S phase relationship: transforms_into CCO:B0014380 ! TIPIN_HUMAN-Phosphoserine222 [Term] id: CCO:B0002105 name: KIFC1_HUMAN def: "Kinesin-like protein KIFC1" [UniProtKB:Q9BW19] synonym: "Kinesin-like protein 2" EXACT [UniProtKB:Q9BW19] synonym: "Kinesin-related protein HSET" EXACT [UniProtKB:Q9BW19] xref: EMBL:AAH00712.2 xref: EMBL:AAH63567.1 xref: EMBL:AAH73878.1 xref: EMBL:AAH98438.1 xref: EMBL:AAI21042.1 xref: EMBL:AAI21043.1 xref: EMBL:BAA03509.1 xref: EMBL:CAA09217.1 xref: EMBL:CAA16157.1 xref: EMBL:CAB63782.1 xref: EMBL:CAI18269.1 xref: EMBL:CAI41792.1 xref: EMBL:CAM26294.1 xref: UniProtKB:O60887 xref: UniProtKB:Q14834 xref: UniProtKB:Q4KMP0 xref: UniProtKB:Q5SU09 xref: UniProtKB:Q6GMS7 xref: UniProtKB:Q6P4A5 xref: UniProtKB:Q9BW19 xref: UniProtKB:Q9UQP7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004951 ! KIFC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012609 ! KIFC1_HUMAN-Phosphoserine33 relationship: transforms_into CCO:B0012610 ! KIFC1_HUMAN-Phosphoserine351 [Term] id: CCO:B0002106 name: SYCP2_HUMAN def: "Synaptonemal complex protein 2" [UniProtKB:Q9BX26] synonym: "hsSCP2" EXACT [UniProtKB:Q9BX26] synonym: "SCP-2" EXACT [UniProtKB:Q9BX26] synonym: "Synaptonemal complex lateral element protein" EXACT [UniProtKB:Q9BX26] xref: EMBL:CAA70171.1 xref: EMBL:CAB45780.1 xref: EMBL:CAC36022.2 xref: EMBL:CAI21795.1 xref: UniProtKB:O75763 xref: UniProtKB:Q5JX11 xref: UniProtKB:Q9BX26 xref: UniProtKB:Q9NTX8 xref: UniProtKB:Q9UG27 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005711 ! SYCP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000119 ! meiotic prophase I relationship: participates_in CCO:P0000121 ! synaptonemal complex assembly [Term] id: CCO:B0002107 name: FANCJ_HUMAN def: "Fanconi anemia group J protein" [UniProtKB:Q9BX63] synonym: "ATP-dependent RNA helicase BRIP1" EXACT [UniProtKB:Q9BX63] synonym: "BRCA1-associated C-terminal helicase 1" EXACT [UniProtKB:Q9BX63] synonym: "BRCA1-interacting protein 1" EXACT [UniProtKB:Q9BX63] synonym: "BRCA1-interacting protein C-terminal helicase 1" EXACT [UniProtKB:Q9BX63] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9BX63] synonym: "Protein FACJ" EXACT [UniProtKB:Q9BX63] xref: EMBL:AAI01473.1 xref: EMBL:AAI01475.1 xref: EMBL:AAK38111.1 xref: EMBL:BAC11156.1 xref: UniProtKB:Q3MJE2 xref: UniProtKB:Q8NCI5 xref: UniProtKB:Q9BX63 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004613 ! BRIP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: transforms_into CCO:B0011849 ! FANCJ_HUMAN-Phosphoserine990 relationship: transforms_into CCO:B0011850 ! FANCJ_HUMAN-Phosphoserine1032 [Term] id: CCO:B0002108 name: NUSAP_HUMAN def: "Nucleolar and spindle-associated protein 1" [UniProtKB:Q9BXS6] synonym: "NuSAP" EXACT [UniProtKB:Q9BXS6] xref: EMBL:AAF24034.1 xref: EMBL:AAF67624.1 xref: EMBL:AAG25874.1 xref: EMBL:AAH01308.1 xref: EMBL:AAH10838.2 xref: EMBL:AAH12887.2 xref: EMBL:AAH24772.1 xref: EMBL:AAK28023.1 xref: EMBL:BAB14586.1 xref: EMBL:BAD96539.1 xref: EMBL:EAW92483.1 xref: UniProtKB:Q53GW2 xref: UniProtKB:Q8TBT4 xref: UniProtKB:Q96E58 xref: UniProtKB:Q96FJ1 xref: UniProtKB:Q9BXS6 xref: UniProtKB:Q9GZM9 xref: UniProtKB:Q9NZ85 xref: UniProtKB:Q9UI70 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005226 ! NUSAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation relationship: participates_in CCO:P0000040 ! cytokinesis after mitosis relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: participates_in CCO:P0000225 ! establishment of mitotic spindle localization relationship: participates_in CCO:P0000251 ! positive regulation of mitosis relationship: transforms_into CCO:B0013327 ! NUSAP_HUMAN-Phosphoserine124 relationship: transforms_into CCO:B0013328 ! NUSAP_HUMAN-Phosphoserine135 relationship: transforms_into CCO:B0013329 ! NUSAP_HUMAN-Phosphothreonine314 [Term] id: CCO:B0002109 name: FACD2_HUMAN def: "Fanconi anemia group D2 protein" [UniProtKB:Q9BXW9] synonym: "Protein FACD2" EXACT [UniProtKB:Q9BXW9] xref: EMBL:AAH13582.1 xref: EMBL:AAK15369.1 xref: EMBL:AAK18772.1 xref: EMBL:AAK18773.1 xref: EMBL:AAL05980.1 xref: EMBL:ABC67466.1 xref: EMBL:BAB14132.1 xref: EMBL:CAH10647.1 xref: UniProtKB:Q2LA86 xref: UniProtKB:Q69YP9 xref: UniProtKB:Q6PJN7 xref: UniProtKB:Q9BQ06 xref: UniProtKB:Q9BXW9 xref: UniProtKB:Q9H9T9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004605 ! FANCD2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006281 ! fancd2-brca2-2 physical interaction relationship: participates_in CCO:I0006422 ! traf6-fancd2 physical interaction relationship: participates_in CCO:I0006440 ! tnfrsf1a-fancd2 physical interaction relationship: participates_in CCO:I0006442 ! tnfrsf1b-fancd2 physical interaction relationship: participates_in CCO:I0006509 ! fance-fancd2-2 physical interaction relationship: participates_in CCO:I0006611 ! fancd2-fance-1 physical interaction relationship: participates_in CCO:I0007073 ! fancd2-brca2-1 physical interaction relationship: participates_in CCO:I0007402 ! fance-fanca-1 physical interaction relationship: participates_in CCO:I0007404 ! fance-fancd2-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011814 ! FACD2_HUMAN-Phosphoserine167 relationship: transforms_into CCO:B0011815 ! FACD2_HUMAN-Phosphoserine178 relationship: transforms_into CCO:B0011816 ! FACD2_HUMAN-Phosphoserine222 relationship: transforms_into CCO:B0011817 ! FACD2_HUMAN-Phosphoserine592 relationship: transforms_into CCO:B0011818 ! FACD2_HUMAN-Phosphothreonine596 relationship: transforms_into CCO:B0011819 ! FACD2_HUMAN-Phosphoserine717 relationship: transforms_into CCO:B0011820 ! FACD2_HUMAN-Phosphoserine1401 relationship: transforms_into CCO:B0011821 ! FACD2_HUMAN-Phosphoserine1404 relationship: transforms_into CCO:B0011822 ! FACD2_HUMAN-Phosphoserine1412 relationship: transforms_into CCO:B0011823 ! FACD2_HUMAN-Phosphoserine1418 [Term] id: CCO:B0002110 name: CADM1_HUMAN def: "Cell adhesion molecule 1 precursor" [UniProtKB:Q9BY67] synonym: "Immunoglobulin superfamily member 4" EXACT [UniProtKB:Q9BY67] synonym: "NECL-2" EXACT [UniProtKB:Q9BY67] synonym: "Nectin-like protein 2" EXACT [UniProtKB:Q9BY67] synonym: "SgIGSF" EXACT [UniProtKB:Q9BY67] synonym: "Spermatogenic immunoglobulin superfamily" EXACT [UniProtKB:Q9BY67] synonym: "Synaptic cell adhesion molecule" EXACT [UniProtKB:Q9BY67] synonym: "TSLC-1" EXACT [UniProtKB:Q9BY67] synonym: "Tumor suppressor in lung cancer 1" EXACT [UniProtKB:Q9BY67] xref: EMBL:AAF69029.1 xref: EMBL:BAC11657.1 xref: EMBL:BAC66178.1 xref: UniProtKB:Q86WB8 xref: UniProtKB:Q8N2F4 xref: UniProtKB:Q9BY67 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004210 ! CADM1_human relationship: has_function CCO:F0001407 ! receptor binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0004335 ! PDZ domain binding relationship: has_function CCO:F0005714 ! protein homodimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000463 ! intercellular junction relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: located_in CCO:C0000780 ! basolateral plasma membrane relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002112 name: PAR6G_HUMAN def: "Partitioning defective 6 homolog gamma" [UniProtKB:Q9BYG4] synonym: "PAR-6 gamma" EXACT [UniProtKB:Q9BYG4] synonym: "PAR6D" EXACT [UniProtKB:Q9BYG4] xref: EMBL:AAH60797.1 xref: EMBL:BAB40757.1 xref: UniProtKB:Q9BYG4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005264 ! PARD6G_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000475 ! tight junction relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000936 ! cell junction relationship: participates_in CCO:I0005992 ! pard6g-prkci-1 physical interaction relationship: participates_in CCO:I0005997 ! pard6g-rac1-1 physical interaction relationship: participates_in CCO:I0005998 ! pard6g-cdc42-1 physical interaction relationship: participates_in CCO:I0006834 ! cdc42-pard6g-1 physical interaction relationship: participates_in CCO:I0006837 ! rac1-pard6g-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002113 name: PAR6B_HUMAN def: "Partitioning defective 6 homolog beta" [UniProtKB:Q9BYG5] synonym: "PAR-6 beta" EXACT [UniProtKB:Q9BYG5] synonym: "PAR-6B" EXACT [UniProtKB:Q9BYG5] xref: EMBL:AAH60847.1 xref: EMBL:BAB40756.1 xref: EMBL:CAB44747.3 xref: UniProtKB:Q9BYG5 xref: UniProtKB:Q9Y510 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005263 ! PARD6B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005990 ! pard6b-prkci-1 physical interaction relationship: participates_in CCO:I0005991 ! pard6b-prkcz-1 physical interaction relationship: participates_in CCO:I0005995 ! pard6b-rac1-1 physical interaction relationship: participates_in CCO:I0005996 ! pard6b-cdc42-4 physical interaction relationship: participates_in CCO:I0006830 ! prkci-pard6b-1 physical interaction relationship: participates_in CCO:I0006831 ! prkcz-pard6b-1 physical interaction relationship: participates_in CCO:I0006833 ! cdc42-pard6b-1 physical interaction relationship: participates_in CCO:I0006836 ! rac1-pard6b-1 physical interaction relationship: participates_in CCO:I0006838 ! pard6b-rac1-2 physical interaction relationship: participates_in CCO:I0006839 ! pard6b-cdc42-5 physical interaction relationship: participates_in CCO:I0007062 ! pard6b-prkci-2 physical interaction relationship: participates_in CCO:I0007063 ! rac1-pard6b-2 physical interaction relationship: participates_in CCO:I0007064 ! cdc42-pard6b-2 physical interaction relationship: participates_in CCO:I0007199 ! pard3-pard6b-2 physical interaction relationship: participates_in CCO:I0007204 ! pard6a-par6b-1 physical interaction relationship: participates_in CCO:I0007207 ! prkci-pard6b-2 physical interaction relationship: participates_in CCO:I0007215 ! pard6b-ywhah-1 physical interaction relationship: participates_in CCO:I0007216 ! pard6b-ywhaz-1 physical interaction relationship: participates_in CCO:I0007225 ! pard6b-cdc42-6 physical interaction relationship: participates_in CCO:I0007226 ! cdc42-pard6b-3 physical interaction relationship: participates_in CCO:I0007227 ! pard6b-pnma1-1 physical interaction relationship: participates_in CCO:I0007228 ! pnma1-pard6b-1 physical interaction relationship: participates_in CCO:I0007229 ! pard6b-prkci-3 physical interaction relationship: participates_in CCO:I0007230 ! pard6b-pard3-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002114 name: Q9BYG9_HUMAN def: "Nucleophosmin/B23.2" [UniProtKB:Q9BYG9] synonym: "Nucleolar phosphoprotein B23, numatrin" EXACT [UniProtKB:Q9BYG9] synonym: "Nucleophosmin" EXACT [UniProtKB:Q9BYG9] xref: EMBL:AAI07755.1 xref: EMBL:BAB40600.1 xref: UniProtKB:Q9BYG9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005212 ! NPM1_human relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0008045 ! NF-kappaB binding relationship: has_function CCO:F0008055 ! unfolded protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: participates_in CCO:P0000108 ! centrosome cycle [Term] id: CCO:B0002115 name: NUF2_HUMAN def: "Kinetochore protein Nuf2" [UniProtKB:Q9BZD4] synonym: "Cell division cycle-associated protein 1" EXACT [UniProtKB:Q9BZD4] synonym: "hNuf2" EXACT [UniProtKB:Q9BZD4] synonym: "hNuf2R" EXACT [UniProtKB:Q9BZD4] synonym: "hsNuf2" EXACT [UniProtKB:Q9BZD4] xref: EMBL:AAH08489.1 xref: EMBL:AAH21171.2 xref: EMBL:AAK01426.1 xref: EMBL:BAB59141.1 xref: EMBL:BAB59142.1 xref: EMBL:BAC04140.1 xref: EMBL:CAI16706.1 xref: UniProtKB:Q8WU69 xref: UniProtKB:Q96HJ4 xref: UniProtKB:Q96Q78 xref: UniProtKB:Q9BZD4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005224 ! NUF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006225 ! cdca1_cenpb_1 colocalization relationship: participates_in CCO:I0006574 ! exoc1-nuf2 physical interaction relationship: participates_in CCO:I0006764 ! kntc2-spbc24-3 physical interaction relationship: participates_in CCO:I0007156 ! kntc2-cdca1-4 physical interaction relationship: participates_in CCO:I0007169 ! kntc2-spbc24-4 physical interaction relationship: participates_in CCO:I0007301 ! kntc2-spbc24-1 physical interaction relationship: participates_in CCO:I0007303 ! kntc2-cdca1-3 physical interaction relationship: participates_in CCO:I0007318 ! cdca1-kntc2 physical interaction relationship: participates_in CCO:I0007463 ! kntc2-cdca1-2 physical interaction relationship: participates_in CCO:I0007473 ! kntc2-cdca1-1 physical interaction relationship: participates_in CCO:I0007932 ! kntc2-spbc24-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013291 ! NUF2_HUMAN-Phosphoserine247 relationship: transforms_into CCO:B0013292 ! NUF2_HUMAN-Phosphothreonine261 [Term] id: CCO:B0002116 name: NOG1_HUMAN def: "Nucleolar GTP-binding protein 1" [UniProtKB:Q9BZE4] synonym: "Chronic renal failure gene protein" EXACT [UniProtKB:Q9BZE4] synonym: "GTP-binding protein NGB" EXACT [UniProtKB:Q9BZE4] xref: EMBL:AAD09830.1 xref: EMBL:AAH38975.1 xref: EMBL:AAK13444.1 xref: EMBL:BAA91752.1 xref: UniProtKB:O95446 xref: UniProtKB:Q9BZE4 xref: UniProtKB:Q9NVJ8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005202 ! GTPBP4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: transforms_into CCO:B0013200 ! NOG1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013201 ! NOG1_HUMAN-Phosphoserine468 relationship: transforms_into CCO:B0013202 ! NOG1_HUMAN-Phosphoserine470 relationship: transforms_into CCO:B0013203 ! NOG1_HUMAN-Phosphoserine472 [Term] id: CCO:B0002117 name: DPH1_HUMAN def: "Diphthamide biosynthesis protein 1" [UniProtKB:Q9BZG8] synonym: "Diphthamide biosynthesis protein 2 homolog-like 1" EXACT [UniProtKB:Q9BZG8] synonym: "Diphthamide biosynthesis protein 2-like" EXACT [UniProtKB:Q9BZG8] synonym: "DPH-like 1" EXACT [UniProtKB:Q9BZG8] synonym: "DPH1 homolog" EXACT [UniProtKB:Q9BZG8] synonym: "DPH2-like 1" EXACT [UniProtKB:Q9BZG8] synonym: "HsDph1" EXACT [UniProtKB:Q9BZG8] synonym: "Ovarian cancer-associated gene 1 protein" EXACT [UniProtKB:Q9BZG8] xref: EMBL:AAB36297.1 xref: EMBL:AAD10198.1 xref: EMBL:AAH03099.1 xref: EMBL:AAH96088.1 xref: EMBL:AAK13428.1 xref: EMBL:AAV38681.1 xref: UniProtKB:Q16439 xref: UniProtKB:Q4VBA2 xref: UniProtKB:Q9BTW7 xref: UniProtKB:Q9BZG8 xref: UniProtKB:Q9UCY0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004499 ! DPH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002118 name: Q9BZU3_HUMAN def: "PNAS-18" [UniProtKB:Q9BZU3] synonym: "CDC28 protein kinase regulatory subunit 1B" EXACT [UniProtKB:Q9BZU3] synonym: "CDC28 protein kinase regulatory subunit 1B, isoform CRA_c" EXACT [UniProtKB:Q9BZU3] xref: EMBL:AAK07520.1 xref: EMBL:CAI13257.1 xref: EMBL:EAW53165.1 xref: UniProtKB:Q9BZU3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004364 ! CKS1B_human relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003204 ! cyclin-dependent protein kinase regulator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002119 name: AL2S2_HUMAN def: "Pseudokinase ALS2CR2" [UniProtKB:Q9C0K7] synonym: "Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein" EXACT [UniProtKB:Q9C0K7] synonym: "CALS-21" EXACT [UniProtKB:Q9C0K7] synonym: "ILP-interacting protein" EXACT [UniProtKB:Q9C0K7] synonym: "STRAD beta" EXACT [UniProtKB:Q9C0K7] xref: EMBL:AAF71042.1 xref: EMBL:AAH08302.1 xref: EMBL:AAH90871.1 xref: EMBL:AAM19143.1 xref: EMBL:AAY14692.1 xref: EMBL:BAB32500.1 xref: EMBL:BAB55254.1 xref: UniProtKB:Q5BKY7 xref: UniProtKB:Q9C0K7 xref: UniProtKB:Q9P1L0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004048 ! ALS2CR2_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:I0007208 ! als2cr2-stk11-1 physical interaction relationship: participates_in CCO:I0007209 ! mo25-als2cr2-1 physical interaction relationship: participates_in CCO:I0007223 ! stk11-als2cr2-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002121 name: Q9GZT1_HUMAN def: "RNA binding protein MCG10" [UniProtKB:Q9GZT1] synonym: "Poly(RC) binding protein 4, isoform CRA_a" EXACT [UniProtKB:Q9GZT1] xref: EMBL:AAG02184.1 xref: EMBL:AAG02186.1 xref: EMBL:EAW65165.1 xref: UniProtKB:Q9GZT1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006047 ! PCBP4_human relationship: has_function CCO:F0000308 ! RNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:P0000065 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002122 name: MIS12_HUMAN def: "Protein MIS12 homolog" [UniProtKB:Q9H081] xref: EMBL:AAH00229.1 xref: EMBL:BAB71088.1 xref: EMBL:CAB66840.1 xref: EMBL:CAG38491.1 xref: UniProtKB:Q96N24 xref: UniProtKB:Q9H081 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005088 ! MIS12_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000092 ! MIS12/MIND type complex relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002124 name: RGAP1_HUMAN def: "Rac GTPase-activating protein 1" [UniProtKB:Q9H0H5] synonym: "MgcRacGAP" EXACT [UniProtKB:Q9H0H5] xref: EMBL:AAH24144.1 xref: EMBL:AAH32754.1 xref: EMBL:BAA90247.1 xref: EMBL:BAA91347.1 xref: EMBL:BAA96002.1 xref: EMBL:CAB66728.1 xref: EMBL:CAG38596.1 xref: UniProtKB:Q6PJ26 xref: UniProtKB:Q9H0H5 xref: UniProtKB:Q9NWN2 xref: UniProtKB:Q9P250 xref: UniProtKB:Q9P2W2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005477 ! RACGAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000059 ! cytokinesis, contractile ring formation relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013837 ! RGAP1_HUMAN-Phosphothreonine161 relationship: transforms_into CCO:B0013838 ! RGAP1_HUMAN-Phosphoserine164 relationship: transforms_into CCO:B0013839 ! RGAP1_HUMAN-Phosphoserine170 relationship: transforms_into CCO:B0013840 ! RGAP1_HUMAN-Phosphoserine185 relationship: transforms_into CCO:B0013841 ! RGAP1_HUMAN-Phosphoserine187 relationship: transforms_into CCO:B0013842 ! RGAP1_HUMAN-Phosphoserine203 relationship: transforms_into CCO:B0013843 ! RGAP1_HUMAN-Phosphoserine206 relationship: transforms_into CCO:B0013844 ! RGAP1_HUMAN-Phosphoserine214 relationship: transforms_into CCO:B0013845 ! RGAP1_HUMAN-Phosphothreonine342 relationship: transforms_into CCO:B0013846 ! RGAP1_HUMAN-Phosphoserine387 relationship: transforms_into CCO:B0013847 ! RGAP1_HUMAN-Phosphothreonine580 relationship: transforms_into CCO:B0013848 ! RGAP1_HUMAN-Phosphothreonine588 relationship: transforms_into CCO:B0013849 ! RGAP1_HUMAN-Phosphoserine590 relationship: transforms_into CCO:B0013850 ! RGAP1_HUMAN-Phosphothreonine606 relationship: transforms_into CCO:B0013851 ! RGAP1_HUMAN-Phosphoserine628 [Term] id: CCO:B0002125 name: APC1_HUMAN def: "Anaphase-promoting complex subunit 1" [UniProtKB:Q9H1A4] synonym: "APC1" EXACT [UniProtKB:Q9H1A4] synonym: "Cyclosome subunit 1" EXACT [UniProtKB:Q9H1A4] synonym: "Mitotic checkpoint regulator" EXACT [UniProtKB:Q9H1A4] synonym: "Testis-specific gene 24 protein" EXACT [UniProtKB:Q9H1A4] xref: EMBL:AAH05089.1 xref: EMBL:AAI04903.1 xref: EMBL:AAI04905.1 xref: EMBL:BAB14687.1 xref: EMBL:CAC19484.1 xref: UniProtKB:Q2M3H8 xref: UniProtKB:Q9BSE6 xref: UniProtKB:Q9H1A4 xref: UniProtKB:Q9H8D0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004054 ! ANAPC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041111 ! APC1_HUMAN-Phosphoserine202 relationship: transforms_into CCO:B0041112 ! APC1_HUMAN-Phosphoserine286 relationship: transforms_into CCO:B0041113 ! APC1_HUMAN-Phosphothreonine291 relationship: transforms_into CCO:B0041114 ! APC1_HUMAN-Phosphoserine355 relationship: transforms_into CCO:B0041115 ! APC1_HUMAN-Phosphoserine373 relationship: transforms_into CCO:B0041116 ! APC1_HUMAN-Phosphoserine377 relationship: transforms_into CCO:B0041117 ! APC1_HUMAN-Phosphothreonine537 relationship: transforms_into CCO:B0041118 ! APC1_HUMAN-Phosphotyrosine571 relationship: transforms_into CCO:B0041119 ! APC1_HUMAN-Phosphoserine686 relationship: transforms_into CCO:B0041120 ! APC1_HUMAN-Phosphoserine688 relationship: transforms_into CCO:B0041121 ! APC1_HUMAN-Phosphoserine731 [Term] id: CCO:B0002126 name: CDT1_HUMAN def: "DNA replication factor Cdt1" [UniProtKB:Q9H211] synonym: "Double parked homolog" EXACT [UniProtKB:Q9H211] synonym: "DUP" EXACT [UniProtKB:Q9H211] xref: EMBL:AAG45181.1 xref: EMBL:AAH00137.2 xref: EMBL:AAH08676.1 xref: EMBL:AAH08860.2 xref: EMBL:AAH09410.1 xref: EMBL:AAH14202.2 xref: EMBL:AAH49205.1 xref: EMBL:BAB61878.1 xref: UniProtKB:Q86XX9 xref: UniProtKB:Q96CJ5 xref: UniProtKB:Q96GK5 xref: UniProtKB:Q96H67 xref: UniProtKB:Q96HE6 xref: UniProtKB:Q9BWM0 xref: UniProtKB:Q9H211 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004315 ! CDT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006854 ! cdt1-gmnn-5 physical interaction relationship: participates_in CCO:I0007239 ! cdt1-cdc6-1 physical interaction relationship: participates_in CCO:I0007240 ! cdt1-cdc6-2 physical interaction relationship: participates_in CCO:I0007405 ! cdt1-gmnn-2 physical interaction relationship: participates_in CCO:I0007406 ! cdt1-gmnn-3 physical interaction relationship: participates_in CCO:I0007533 ! cdt1-cdk2-1 physical interaction relationship: participates_in CCO:I0007957 ! cdt1-gmnn-4 physical interaction relationship: participates_in CCO:P0000007 ! DNA replication checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011129 ! CDT1_HUMAN-Phosphoserine318 [Term] id: CCO:B0002127 name: Q9H2F0_HUMAN def: "Cell division cycle 25C splice variant 3" [UniProtKB:Q9H2F0] xref: EMBL:AAG41886.1 xref: UniProtKB:Q9H2F0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005119 ! CDC25C_human relationship: has_function CCO:F0001090 ! protein tyrosine phosphatase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle [Term] id: CCO:B0002128 name: TSYL2_HUMAN def: "Testis-specific Y-encoded-like protein 2" [UniProtKB:Q9H2G4] synonym: "Cell division autoantigen 1" EXACT [UniProtKB:Q9H2G4] synonym: "CTCL tumor antigen se20-4" EXACT [UniProtKB:Q9H2G4] synonym: "Cutaneous T-cell lymphoma-associated antigen se20-4" EXACT [UniProtKB:Q9H2G4] synonym: "Differentially-expressed nucleolar TGF-beta1 target protein" EXACT [UniProtKB:Q9H2G4] synonym: "NP79" EXACT [UniProtKB:Q9H2G4] synonym: "Nuclear protein of 79 kDa" EXACT [UniProtKB:Q9H2G4] synonym: "TSPY-like protein 2" EXACT [UniProtKB:Q9H2G4] xref: EMBL:AAG34906.1 xref: EMBL:AAG53596.1 xref: EMBL:AAH01566.1 xref: EMBL:AAH24270.1 xref: EMBL:AAK72407.1 xref: EMBL:BAA34802.1 xref: EMBL:CAD28461.1 xref: EMBL:CAI42531.1 xref: UniProtKB:O94799 xref: UniProtKB:Q96DG7 xref: UniProtKB:Q9BZW6 xref: UniProtKB:Q9H2G4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005841 ! TSPYL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0014549 ! TSYL2_HUMAN-Phosphoserine16 relationship: transforms_into CCO:B0014550 ! TSYL2_HUMAN-Phosphoserine17 relationship: transforms_into CCO:B0014551 ! TSYL2_HUMAN-Phosphoserine20 relationship: transforms_into CCO:B0014552 ! TSYL2_HUMAN-Phosphothreonine340 [Term] id: CCO:B0002129 name: RASF4_HUMAN def: "Ras association domain-containing protein 4" [UniProtKB:Q9H2L5] xref: EMBL:AAG44666.1 xref: EMBL:AAH32593.1 xref: EMBL:AAO61138.1 xref: EMBL:AAO61139.1 xref: EMBL:AAO61140.1 xref: EMBL:AAO61141.1 xref: EMBL:CAD28511.1 xref: EMBL:CAI13063.1 xref: UniProtKB:Q86WH5 xref: UniProtKB:Q86WH6 xref: UniProtKB:Q86WH7 xref: UniProtKB:Q8N5A9 xref: UniProtKB:Q8TCK6 xref: UniProtKB:Q9H2L5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005431 ! RASSF4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002131 name: PININ_HUMAN def: "Pinin" [UniProtKB:Q9H307] synonym: "140 kDa nuclear and cell adhesion-related phosphoprotein" EXACT [UniProtKB:Q9H307] synonym: "Desmosome-associated protein" EXACT [UniProtKB:Q9H307] synonym: "Domain-rich serine protein" EXACT [UniProtKB:Q9H307] synonym: "DRS protein" EXACT [UniProtKB:Q9H307] synonym: "DRSP" EXACT [UniProtKB:Q9H307] synonym: "Melanoma metastasis clone A protein" EXACT [UniProtKB:Q9H307] synonym: "Nuclear protein SDK3" EXACT [UniProtKB:Q9H307] synonym: "SR-like protein" EXACT [UniProtKB:Q9H307] xref: EMBL:AAB48304.1 xref: EMBL:AAF17209.1 xref: EMBL:AAG33941.1 xref: EMBL:AAH62602.1 xref: EMBL:BAD97332.1 xref: EMBL:CAA70874.1 xref: EMBL:CAA71377.1 xref: UniProtKB:O60899 xref: UniProtKB:Q53EM7 xref: UniProtKB:Q6P5X4 xref: UniProtKB:Q7KYL1 xref: UniProtKB:Q99738 xref: UniProtKB:Q9H307 xref: UniProtKB:Q9UHZ9 xref: UniProtKB:Q9UQR9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005317 ! PNN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008320 ! pnn-pdpk1 physical interaction relationship: participates_in CCO:I0008504 ! pnn-vamp8 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013515 ! PININ_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013516 ! PININ_HUMAN-Phosphoserine66 relationship: transforms_into CCO:B0013517 ! PININ_HUMAN-Phosphoserine96 relationship: transforms_into CCO:B0013518 ! PININ_HUMAN-Phosphoserine100 relationship: transforms_into CCO:B0013519 ! PININ_HUMAN-Phosphoserine114 relationship: transforms_into CCO:B0013520 ! PININ_HUMAN-Phosphoserine347 relationship: transforms_into CCO:B0013521 ! PININ_HUMAN-Phosphoserine381 relationship: transforms_into CCO:B0013522 ! PININ_HUMAN-Phosphoserine441 relationship: transforms_into CCO:B0013523 ! PININ_HUMAN-Phosphoserine443 relationship: transforms_into CCO:B0013524 ! PININ_HUMAN-Phosphoserine649 relationship: transforms_into CCO:B0013525 ! PININ_HUMAN-Phosphoserine658 relationship: transforms_into CCO:B0013526 ! PININ_HUMAN-Phosphoserine663 relationship: transforms_into CCO:B0013527 ! PININ_HUMAN-Phosphoserine666 relationship: transforms_into CCO:B0013528 ! PININ_HUMAN-Phosphoserine667 relationship: transforms_into CCO:B0013529 ! PININ_HUMAN-Phosphoserine671 relationship: transforms_into CCO:B0013530 ! PININ_HUMAN-Phosphoserine672 relationship: transforms_into CCO:B0013531 ! PININ_HUMAN-Phosphoserine690 relationship: transforms_into CCO:B0013532 ! PININ_HUMAN-Phosphoserine692 relationship: transforms_into CCO:B0013533 ! PININ_HUMAN-Phosphoserine695 [Term] id: CCO:B0002132 name: Q9H315_HUMAN def: "ARTS protein" [UniProtKB:Q9H315] synonym: "Septin 4, isoform CRA_c" EXACT [UniProtKB:Q9H315] xref: EMBL:AAG45673.1 xref: EMBL:EAW94442.1 xref: UniProtKB:Q9H315 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006048 ! PNUTL2_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000325 ! mitochondrion relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002133 name: TXNIP_HUMAN def: "Thioredoxin-interacting protein" [UniProtKB:Q9H3M7] synonym: "Thioredoxin-binding protein 2" EXACT [UniProtKB:Q9H3M7] synonym: "Vitamin D3 up-regulated protein 1" EXACT [UniProtKB:Q9H3M7] xref: EMBL:AAB31977.2 xref: EMBL:AAH93702.1 xref: EMBL:AAH93704.1 xref: EMBL:AAK37514.1 xref: EMBL:AAT01927.2 xref: EMBL:BAB18859.1 xref: EMBL:CAI22351.1 xref: UniProtKB:Q16226 xref: UniProtKB:Q6PML0 xref: UniProtKB:Q9BXG9 xref: UniProtKB:Q9H3M7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005849 ! TXNIP_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002134 name: DSN1_HUMAN def: "Kinetochore-associated protein DSN1 homolog" [UniProtKB:Q9H410] xref: EMBL:AAH58899.1 xref: EMBL:BAB14564.1 xref: EMBL:BAC04024.1 xref: EMBL:CAC10099.2 xref: UniProtKB:Q5JW56 xref: UniProtKB:Q9H410 xref: UniProtKB:Q9H8P4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004513 ! DSN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011591 ! DSN1_HUMAN-Phosphoserine28 relationship: transforms_into CCO:B0011592 ! DSN1_HUMAN-Phosphoserine30 relationship: transforms_into CCO:B0011593 ! DSN1_HUMAN-Phosphoserine86 [Term] id: CCO:B0002137 name: RGC32_HUMAN def: "Response gene to complement 32 protein" [UniProtKB:Q9H4X1] synonym: "RGC-32" EXACT [UniProtKB:Q9H4X1] xref: EMBL:AAF04336.1 xref: EMBL:AAH66334.1 xref: EMBL:CAC13101.1 xref: UniProtKB:Q6NZ48 xref: UniProtKB:Q9H4X1 xref: UniProtKB:Q9UL69 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005478 ! RGC32_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013852 ! RGC32_HUMAN-Phosphoserine9 relationship: transforms_into CCO:B0013853 ! RGC32_HUMAN-Phosphoserine29 relationship: transforms_into CCO:B0013854 ! RGC32_HUMAN-Phosphoserine44 relationship: transforms_into CCO:B0013855 ! RGC32_HUMAN-Phosphothreonine111 [Term] id: CCO:B0002139 name: SUV92_HUMAN def: "Histone-lysine N-methyltransferase SUV39H2" [UniProtKB:Q9H5I1] synonym: "EC 2.1.1.43" EXACT [UniProtKB:Q9H5I1] synonym: "H3-K9-HMTase 2" EXACT [UniProtKB:Q9H5I1] synonym: "Histone H3-K9 methyltransferase 2" EXACT [UniProtKB:Q9H5I1] synonym: "Lysine N-methyltransferase 1B" EXACT [UniProtKB:Q9H5I1] synonym: "Su(var)3-9 homolog 2" EXACT [UniProtKB:Q9H5I1] synonym: "Suppressor of variegation 3-9 homolog 2" EXACT [UniProtKB:Q9H5I1] xref: EMBL:AAH07754.1 xref: EMBL:AAH29360.1 xref: EMBL:BAB15645.1 xref: EMBL:CAD39146.1 xref: EMBL:CAG33653.1 xref: EMBL:CAI40028.1 xref: EMBL:CAI40032.1 xref: UniProtKB:Q5JSS5 xref: UniProtKB:Q6I9Y3 xref: UniProtKB:Q8ND06 xref: UniProtKB:Q9H5I1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005707 ! SUV39H2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005932 ! ewsr1-suv39h2 physical interaction relationship: participates_in CCO:I0008510 ! suv39h2-ube2v2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002141 name: Q9H8U2_HUMAN def: "cDNA FLJ13223 fis, clone OVARC1000001, highly similar to Homo sapiens actin binding protein ABP620" [UniProtKB:Q9H8U2] xref: EMBL:BAB14509.1 xref: UniProtKB:Q9H8U2 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002142 name: CLSPN_HUMAN def: "Claspin" [UniProtKB:Q9HAW4] synonym: "hClaspin" EXACT [UniProtKB:Q9HAW4] synonym: "Hu-Claspin" EXACT [UniProtKB:Q9HAW4] xref: EMBL:AAG24515.1 xref: EMBL:AAH38991.1 xref: EMBL:AAH62215.1 xref: EMBL:CAH73807.1 xref: UniProtKB:Q5VYG0 xref: UniProtKB:Q6P6H5 xref: UniProtKB:Q8IWI1 xref: UniProtKB:Q9HAW4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004372 ! CLSPN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011267 ! CLSPN_HUMAN-Phosphoserine65 relationship: transforms_into CCO:B0011268 ! CLSPN_HUMAN-Phosphoserine67 relationship: transforms_into CCO:B0011269 ! CLSPN_HUMAN-Phosphoserine75 relationship: transforms_into CCO:B0011270 ! CLSPN_HUMAN-Phosphoserine762 relationship: transforms_into CCO:B0011271 ! CLSPN_HUMAN-Phosphoserine764 relationship: transforms_into CCO:B0011272 ! CLSPN_HUMAN-Phosphoserine833 relationship: transforms_into CCO:B0011273 ! CLSPN_HUMAN-Phosphoserine839 relationship: transforms_into CCO:B0011274 ! CLSPN_HUMAN-Phosphoserine846 relationship: transforms_into CCO:B0011275 ! CLSPN_HUMAN-Phosphoserine950 relationship: transforms_into CCO:B0011276 ! CLSPN_HUMAN-Phosphothreonine1287 relationship: transforms_into CCO:B0011277 ! CLSPN_HUMAN-Phosphoserine1289 [Term] id: CCO:B0002143 name: SPC25_HUMAN def: "Kinetochore protein Spc25" [UniProtKB:Q9HBM1] synonym: "hSpc25" EXACT [UniProtKB:Q9HBM1] xref: EMBL:AAG09718.1 xref: EMBL:AAH22255.1 xref: EMBL:AAR88652.1 xref: EMBL:AAY24098.1 xref: EMBL:CAG33478.1 xref: UniProtKB:Q9HBM1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005655 ! SPC25_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0006064 ! kntc2-spbc25-1 physical interaction relationship: participates_in CCO:I0006065 ! kntc2-spbc25-2 physical interaction relationship: participates_in CCO:I0006224 ! spbc24-spbc25-4 physical interaction relationship: participates_in CCO:I0006764 ! kntc2-spbc24-3 physical interaction relationship: participates_in CCO:I0006765 ! kntc2-spbc25-4 physical interaction relationship: participates_in CCO:I0006908 ! kntc2-spbc25-3 physical interaction relationship: participates_in CCO:I0007169 ! kntc2-spbc24-4 physical interaction relationship: participates_in CCO:I0007301 ! kntc2-spbc24-1 physical interaction relationship: participates_in CCO:I0007302 ! spbc24-spbc25-3 physical interaction relationship: participates_in CCO:I0007464 ! spbc24-spbc25-1 physical interaction relationship: participates_in CCO:I0007465 ! spbc24-spbc25-2 physical interaction relationship: participates_in CCO:I0007816 ! spbc24-spbc25-5 colocalization relationship: participates_in CCO:I0007932 ! kntc2-spbc24-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002144 name: EMAL4_HUMAN def: "Echinoderm microtubule-associated protein-like 4" [UniProtKB:Q9HC35] synonym: "EMAP-4" EXACT [UniProtKB:Q9HC35] synonym: "Restrictedly overexpressed proliferation-associated protein" EXACT [UniProtKB:Q9HC35] synonym: "Ropp 120" EXACT [UniProtKB:Q9HC35] xref: EMBL:AAG09279.2 xref: EMBL:AAH23522.1 xref: EMBL:AAI04648.1 xref: EMBL:AAY14895.1 xref: EMBL:AAY15086.1 xref: EMBL:BAA91919.1 xref: UniProtKB:Q3SWW0 xref: UniProtKB:Q53R29 xref: UniProtKB:Q53TW8 xref: UniProtKB:Q6PJ45 xref: UniProtKB:Q9HC35 xref: UniProtKB:Q9NV40 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004564 ! EML4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008355 ! arf4l-eml4 physical interaction relationship: participates_in CCO:I0008357 ! arih2-eml4 physical interaction relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011680 ! EMAL4_HUMAN-Phosphoserine87 relationship: transforms_into CCO:B0011681 ! EMAL4_HUMAN-Phosphoserine144 relationship: transforms_into CCO:B0011682 ! EMAL4_HUMAN-Phosphoserine146 relationship: transforms_into CCO:B0011683 ! EMAL4_HUMAN-Phosphotyrosine226 relationship: transforms_into CCO:B0011684 ! EMAL4_HUMAN-Phosphotyrosine499 relationship: transforms_into CCO:B0011685 ! EMAL4_HUMAN-Phosphoserine502 relationship: transforms_into CCO:B0011686 ! EMAL4_HUMAN-Phosphothreonine899 [Term] id: CCO:B0002145 name: NEK6_HUMAN def: "Serine/threonine-protein kinase Nek6" [UniProtKB:Q9HC98] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9HC98] synonym: "NimA-related protein kinase 6" EXACT [UniProtKB:Q9HC98] synonym: "Protein kinase SID6-1512" EXACT [UniProtKB:Q9HC98] xref: EMBL:AAG13417.1 xref: EMBL:AAH00101.2 xref: EMBL:AAH04174.2 xref: EMBL:AAH04209.2 xref: EMBL:AAH12761.1 xref: EMBL:BAA85045.1 xref: UniProtKB:Q96E83 xref: UniProtKB:Q9HC98 xref: UniProtKB:Q9ULX2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005178 ! NEK6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006459 ! pin1-nek6-1 physical interaction relationship: participates_in CCO:I0007509 ! pin1-nek6-2 physical interaction relationship: participates_in CCO:I0007510 ! pin1-nek6-3 colocalization relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition [Term] id: CCO:B0002147 name: BRMS1_HUMAN def: "Breast cancer metastasis-suppressor 1" [UniProtKB:Q9HCU9] xref: EMBL:AAG00075.1 xref: EMBL:AAH09834.1 xref: EMBL:AAK69131.1 xref: UniProtKB:Q9HCU9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004191 ! BRMS1_human relationship: has_function CCO:F0000272 ! molecular_function relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:I0006821 ! brms1-hdac1 physical interaction relationship: participates_in CCO:I0006822 ! brms1-hdac2 physical interaction relationship: participates_in CCO:I0006823 ! brms1-hdac4 physical interaction relationship: participates_in CCO:I0006824 ! brms1-hdac5 physical interaction relationship: participates_in CCO:I0006825 ! brms1-hdac6 physical interaction relationship: participates_in CCO:I0006936 ! brms1-arid4a physical interaction relationship: participates_in CCO:I0006937 ! brms1-sds3 physical interaction relationship: participates_in CCO:I0006938 ! brms1-smarce1 physical interaction relationship: participates_in CCO:I0006939 ! brms1-taf1 physical interaction relationship: participates_in CCO:I0006940 ! brms1-nmi physical interaction relationship: participates_in CCO:I0006941 ! brms1-dnajb6 physical interaction relationship: participates_in CCO:I0006942 ! brms1-kpna5 physical interaction relationship: participates_in CCO:I0006943 ! brms1-hspa8 physical interaction relationship: participates_in CCO:I0007189 ! hdac1-brms1 physical interaction relationship: participates_in CCO:I0007190 ! hdac2-brms1 physical interaction relationship: participates_in CCO:I0007191 ! hdac3-brms1 physical interaction relationship: participates_in CCO:I0007192 ! hdac4-brms1 physical interaction relationship: participates_in CCO:I0007193 ! hdac5-brms1 physical interaction relationship: participates_in CCO:I0007194 ! hdac6-brms1 physical interaction relationship: participates_in CCO:I0007719 ! sds3-brms1 physical interaction relationship: participates_in CCO:I0007720 ! dnajb6-brms1 physical interaction relationship: participates_in CCO:I0007721 ! nmi-brms1 physical interaction relationship: participates_in CCO:I0007722 ! smarce1-brms1 physical interaction relationship: participates_in CCO:I0008202 ! brms1-eef1a1 physical interaction relationship: participates_in CCO:I0008203 ! brms1-rif1 physical interaction relationship: participates_in CCO:I0008391 ! golgb1-brms1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002148 name: CHM1A_HUMAN def: "Charged multivesicular body protein 1a" [UniProtKB:Q9HD42] synonym: "CHMP1a" EXACT [UniProtKB:Q9HD42] synonym: "Chromatin-modifying protein 1a" EXACT [UniProtKB:Q9HD42] synonym: "hVps46-1" EXACT [UniProtKB:Q9HD42] synonym: "Vacuolar protein-sorting-associated protein 46-1" EXACT [UniProtKB:Q9HD42] synonym: "Vps46-1" EXACT [UniProtKB:Q9HD42] xref: EMBL:AAC50775.1 xref: EMBL:AAG01448.1 xref: EMBL:AAH10000.2 xref: EMBL:AAP35487.1 xref: EMBL:BAA07557.1 xref: UniProtKB:Q14468 xref: UniProtKB:Q15779 xref: UniProtKB:Q96G31 xref: UniProtKB:Q9HD42 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004349 ! CHMP1A_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001787 ! metallopeptidase activity relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0004213 ! protein domain specific binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000121 ! condensed nuclear chromosome relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000351 ! endosome relationship: located_in CCO:C0000352 ! early endosome relationship: located_in CCO:C0000385 ! microtubule organizing center relationship: located_in CCO:C0000713 ! endosome membrane relationship: located_in CCO:C0000733 ! endomembrane system relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000785 ! nuclear matrix relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: participates_in CCO:P0000244 ! negative regulation of S phase of mitotic cell cycle [Term] id: CCO:B0002149 name: PRM3_HUMAN def: "Protamine-3" [UniProtKB:Q9NNZ6] synonym: "Sperm protamine P3" EXACT [UniProtKB:Q9NNZ6] xref: EMBL:CAB92526.1 xref: UniProtKB:Q9NNZ6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005379 ! PRM3_human relationship: has_function CCO:F0000272 ! molecular_function relationship: has_function CCO:F0000274 ! DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000113 ! nucleosome relationship: located_in CCO:C0000200 ! cellular_component relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000296 ! chromosome relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation [Term] id: CCO:B0002150 name: PAR6A_HUMAN def: "Partitioning defective 6 homolog alpha" [UniProtKB:Q9NPB6] synonym: "PAR-6" EXACT [UniProtKB:Q9NPB6] synonym: "PAR-6 alpha" EXACT [UniProtKB:Q9NPB6] synonym: "PAR-6A" EXACT [UniProtKB:Q9NPB6] synonym: "PAR6C" EXACT [UniProtKB:Q9NPB6] synonym: "Tax interaction protein 40" EXACT [UniProtKB:Q9NPB6] synonym: "TIP-40" EXACT [UniProtKB:Q9NPB6] xref: EMBL:AAB84252.1 xref: EMBL:AAF71529.1 xref: EMBL:AAF75548.1 xref: EMBL:AAH15626.1 xref: EMBL:BAA96235.1 xref: EMBL:BAB16105.1 xref: EMBL:CAB85490.1 xref: UniProtKB:O14911 xref: UniProtKB:Q9NPB6 xref: UniProtKB:Q9NPJ7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005262 ! PARD6A_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001738 ! transcription factor binding relationship: has_function CCO:F0003531 ! Rho GTPase binding relationship: has_function CCO:F0004538 ! GTP-dependent protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000475 ! tight junction relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000936 ! cell junction relationship: participates_in CCO:I0005724 ! pard6a-prkci physical interaction relationship: participates_in CCO:I0005940 ! pard6a-prkcz physical interaction relationship: participates_in CCO:I0005988 ! pard6a-prkci-1 physical interaction relationship: participates_in CCO:I0005989 ! pard6a-prkcz-1 physical interaction relationship: participates_in CCO:I0005993 ! pard6a-rac1-2 physical interaction relationship: participates_in CCO:I0005994 ! pard6a-cdc42-4 physical interaction relationship: participates_in CCO:I0006238 ! pard6a-prkci-3 direct interaction relationship: participates_in CCO:I0006465 ! pard3-pard6a-1 physical interaction relationship: participates_in CCO:I0006466 ! pard6a-pard3-1 physical interaction relationship: participates_in CCO:I0006467 ! prcki-pard6-1 physical interaction relationship: participates_in CCO:I0006631 ! pard6a-tcp10-2 physical interaction relationship: participates_in CCO:I0006632 ! pard6a-cdc42-2 physical interaction relationship: participates_in CCO:I0006633 ! pard6a-tcp10-3 physical interaction relationship: participates_in CCO:I0006634 ! pard6a-cdc42-3 physical interaction relationship: participates_in CCO:I0006832 ! cdc42-pard6a-1 physical interaction relationship: participates_in CCO:I0006835 ! rac1-pard6a-1 physical interaction relationship: participates_in CCO:I0007200 ! pard3-pard6a-3 physical interaction relationship: participates_in CCO:I0007202 ! pard3-pard6a-2 physical interaction relationship: participates_in CCO:I0007203 ! pard6a-prkci-2 physical interaction relationship: participates_in CCO:I0007204 ! pard6a-par6b-1 physical interaction relationship: participates_in CCO:I0007205 ! pard6a-cdc42-5 physical interaction relationship: participates_in CCO:I0007206 ! prkci-pard6a-1 physical interaction relationship: participates_in CCO:I0007210 ! pard6a-mark4-1 physical interaction relationship: participates_in CCO:I0007213 ! pard6a-ywhah-1 physical interaction relationship: participates_in CCO:I0007214 ! pard6a-ywhaz-1 physical interaction relationship: participates_in CCO:I0007224 ! cdc42-pard6a-2 physical interaction relationship: participates_in CCO:I0007520 ! pard6a-prcki-1 physical interaction relationship: participates_in CCO:I0007521 ! prcki-pard6a-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002153 name: CYLD_HUMAN def: "Probable ubiquitin carboxyl-terminal hydrolase CYLD" [UniProtKB:Q9NQC7] synonym: "Deubiquitinating enzyme CYLD" EXACT [UniProtKB:Q9NQC7] synonym: "EC 3.1.2.15" EXACT [UniProtKB:Q9NQC7] synonym: "Ubiquitin thioesterase CYLD" EXACT [UniProtKB:Q9NQC7] synonym: "Ubiquitin-specific-processing protease CYLD" EXACT [UniProtKB:Q9NQC7] xref: EMBL:AAF29029.1 xref: EMBL:AAH12342.1 xref: EMBL:BAA74872.2 xref: EMBL:CAB93533.1 xref: UniProtKB:O94934 xref: UniProtKB:Q7L3N6 xref: UniProtKB:Q96EH0 xref: UniProtKB:Q9NQC7 xref: UniProtKB:Q9NZX9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004430 ! CYLD_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011419 ! CYLD_HUMAN-Phosphoserine399 [Term] id: CCO:B0002154 name: INCE_HUMAN def: "Inner centromere protein" [UniProtKB:Q9NQS7] xref: EMBL:AAF87584.1 xref: EMBL:AAH98576.1 xref: EMBL:AAU04398.1 xref: UniProtKB:Q5Y192 xref: UniProtKB:Q9NQS7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004891 ! INCENP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006674 ! incenp-cbx5-1 physical interaction relationship: participates_in CCO:I0007394 ! incenp-cbx5-2 physical interaction relationship: participates_in CCO:I0007395 ! cbx5-incenp-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012381 ! INCE_HUMAN-Phosphotyrosine73 relationship: transforms_into CCO:B0012382 ! INCE_HUMAN-Phosphoserine119 relationship: transforms_into CCO:B0012383 ! INCE_HUMAN-Phosphoserine142 relationship: transforms_into CCO:B0012384 ! INCE_HUMAN-Phosphoserine143 relationship: transforms_into CCO:B0012385 ! INCE_HUMAN-Phosphoserine148 relationship: transforms_into CCO:B0012386 ! INCE_HUMAN-Phosphoserine197 relationship: transforms_into CCO:B0012387 ! INCE_HUMAN-Phosphothreonine199 relationship: transforms_into CCO:B0012388 ! INCE_HUMAN-Phosphothreonine213 relationship: transforms_into CCO:B0012389 ! INCE_HUMAN-Phosphoserine214 relationship: transforms_into CCO:B0012390 ! INCE_HUMAN-Phosphothreonine219 relationship: transforms_into CCO:B0012391 ! INCE_HUMAN-Phosphoserine230 relationship: transforms_into CCO:B0012392 ! INCE_HUMAN-Phosphothreonine239 relationship: transforms_into CCO:B0012393 ! INCE_HUMAN-Phosphoserine263 relationship: transforms_into CCO:B0012394 ! INCE_HUMAN-Phosphoserine269 relationship: transforms_into CCO:B0012395 ! INCE_HUMAN-Phosphoserine275 relationship: transforms_into CCO:B0012396 ! INCE_HUMAN-Phosphoserine291 relationship: transforms_into CCO:B0012397 ! INCE_HUMAN-Phosphothreonine292 relationship: transforms_into CCO:B0012398 ! INCE_HUMAN-Phosphothreonine294 relationship: transforms_into CCO:B0012399 ! INCE_HUMAN-Phosphoserine296 relationship: transforms_into CCO:B0012400 ! INCE_HUMAN-Phosphothreonine298 relationship: transforms_into CCO:B0012401 ! INCE_HUMAN-Phosphoserine306 relationship: transforms_into CCO:B0012402 ! INCE_HUMAN-Phosphoserine312 relationship: transforms_into CCO:B0012403 ! INCE_HUMAN-Phosphoserine314 relationship: transforms_into CCO:B0012404 ! INCE_HUMAN-Phosphoserine421 relationship: transforms_into CCO:B0012405 ! INCE_HUMAN-Phosphothreonine424 relationship: transforms_into CCO:B0012406 ! INCE_HUMAN-Phosphoserine481 relationship: transforms_into CCO:B0012407 ! INCE_HUMAN-Phosphoserine833 relationship: transforms_into CCO:B0012408 ! INCE_HUMAN-Phosphoserine836 relationship: transforms_into CCO:B0012409 ! INCE_HUMAN-Phosphothreonine837 relationship: transforms_into CCO:B0012410 ! INCE_HUMAN-Phosphothreonine897 relationship: transforms_into CCO:B0012411 ! INCE_HUMAN-Phosphoserine898 relationship: transforms_into CCO:B0012412 ! INCE_HUMAN-Phosphoserine899 relationship: transforms_into CCO:B0012413 ! INCE_HUMAN-Phosphoserine904 [Term] id: CCO:B0002155 name: ANLN_HUMAN def: "Actin-binding protein anillin" [UniProtKB:Q9NQW6] xref: EMBL:AAF75796.1 xref: EMBL:AAH34692.1 xref: EMBL:AAH70066.1 xref: EMBL:BAA91710.1 xref: EMBL:BAA91711.1 xref: EMBL:BAB14463.1 xref: EMBL:CAI56788.1 xref: UniProtKB:Q5CZ78 xref: UniProtKB:Q6NSK5 xref: UniProtKB:Q9H8Y4 xref: UniProtKB:Q9NQW6 xref: UniProtKB:Q9NVN9 xref: UniProtKB:Q9NVP0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004062 ! ANLN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis relationship: transforms_into CCO:B0010537 ! ANLN_HUMAN-Phosphoserine99 relationship: transforms_into CCO:B0010538 ! ANLN_HUMAN-Phosphoserine182 relationship: transforms_into CCO:B0010539 ! ANLN_HUMAN-Phosphothreonine194 relationship: transforms_into CCO:B0010540 ! ANLN_HUMAN-Phosphothreonine320 relationship: transforms_into CCO:B0010541 ! ANLN_HUMAN-Phosphoserine323 relationship: transforms_into CCO:B0010542 ! ANLN_HUMAN-Phosphoserine362 relationship: transforms_into CCO:B0010543 ! ANLN_HUMAN-Phosphothreonine368 relationship: transforms_into CCO:B0010544 ! ANLN_HUMAN-Phosphothreonine401 relationship: transforms_into CCO:B0010545 ! ANLN_HUMAN-Phosphoserine449 relationship: transforms_into CCO:B0010546 ! ANLN_HUMAN-Phosphoserine485 relationship: transforms_into CCO:B0010547 ! ANLN_HUMAN-Phosphothreonine515 relationship: transforms_into CCO:B0010548 ! ANLN_HUMAN-Phosphoserine637 relationship: transforms_into CCO:B0010549 ! ANLN_HUMAN-Phosphoserine927 [Term] id: CCO:B0002156 name: BIN3_HUMAN def: "Bridging integrator 3" [UniProtKB:Q9NQY0] xref: EMBL:AAF76218.1 xref: EMBL:AAH01223.1 xref: EMBL:AAH09824.1 xref: EMBL:BAA91603.1 xref: EMBL:BAB14751.1 xref: UniProtKB:Q9BVG2 xref: UniProtKB:Q9NQY0 xref: UniProtKB:Q9NVY9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004164 ! BIN3_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001706 ! cytoskeletal adaptor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000421 ! cytoskeleton relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002159 name: LATS2_HUMAN def: "Serine/threonine-protein kinase LATS2" [UniProtKB:Q9NRM7] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9NRM7] synonym: "Kinase phosphorylated during mitosis protein" EXACT [UniProtKB:Q9NRM7] synonym: "Large tumor suppressor homolog 2" EXACT [UniProtKB:Q9NRM7] synonym: "Serine/threonine-protein kinase kpm" EXACT [UniProtKB:Q9NRM7] synonym: "Warts-like kinase" EXACT [UniProtKB:Q9NRM7] xref: EMBL:AAF80561.1 xref: EMBL:BAA92381.1 xref: UniProtKB:Q9NRM7 xref: UniProtKB:Q9P2X1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004972 ! LATS2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0012682 ! LATS2_HUMAN-Phosphoserine83 [Term] id: CCO:B0002160 name: GRLF1_HUMAN def: "Glucocorticoid receptor DNA-binding factor 1" [UniProtKB:Q9NRY4] synonym: "Glucocorticoid receptor repression factor 1" EXACT [UniProtKB:Q9NRY4] synonym: "GRF-1" EXACT [UniProtKB:Q9NRY4] synonym: "p190-A" EXACT [UniProtKB:Q9NRY4] synonym: "Rho GAP p190A" EXACT [UniProtKB:Q9NRY4] xref: EMBL:AAA58618.1 xref: EMBL:AAF80386.1 xref: EMBL:BAB21813.2 xref: UniProtKB:Q14452 xref: UniProtKB:Q9C0E1 xref: UniProtKB:Q9NRY4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004729 ! GRLF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0011975 ! GRLF1_HUMAN-Phosphothreonine685 relationship: transforms_into CCO:B0011976 ! GRLF1_HUMAN-Phosphoserine773 relationship: transforms_into CCO:B0011977 ! GRLF1_HUMAN-Phosphoserine980 relationship: transforms_into CCO:B0011978 ! GRLF1_HUMAN-Phosphotyrosine1105 relationship: transforms_into CCO:B0011979 ! GRLF1_HUMAN-Phosphoserine1134 relationship: transforms_into CCO:B0011980 ! GRLF1_HUMAN-Phosphoserine1179 relationship: transforms_into CCO:B0011981 ! GRLF1_HUMAN-Phosphoserine1195 relationship: transforms_into CCO:B0026378 ! GRLF1_HUMAN-Phosphoserine1150 relationship: transforms_into CCO:B0031328 ! GRLF1_HUMAN-Phosphotyrosine1087 [Term] id: CCO:B0002161 name: HELLS_HUMAN def: "Lymphoid-specific helicase" [UniProtKB:Q9NRZ9] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9NRZ9] synonym: "Proliferation-associated SNF2-like protein" EXACT [UniProtKB:Q9NRZ9] synonym: "SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6" EXACT [UniProtKB:Q9NRZ9] xref: EMBL:AAF82262.1 xref: EMBL:AAG01987.1 xref: EMBL:AAH15477.1 xref: EMBL:AAH29381.1 xref: EMBL:AAH30963.1 xref: EMBL:AAH31004.1 xref: EMBL:BAD10845.1 xref: EMBL:BAD10846.1 xref: EMBL:BAD10847.1 xref: EMBL:BAD10848.1 xref: EMBL:BAD10849.1 xref: EMBL:BAD10850.1 xref: EMBL:BAD24805.1 xref: EMBL:BAE45737.1 xref: EMBL:CAD13191.1 xref: EMBL:CAD97978.1 xref: UniProtKB:Q3LID1 xref: UniProtKB:Q6I7N7 xref: UniProtKB:Q76H76 xref: UniProtKB:Q76H77 xref: UniProtKB:Q76H78 xref: UniProtKB:Q76H79 xref: UniProtKB:Q76H80 xref: UniProtKB:Q76H81 xref: UniProtKB:Q7Z397 xref: UniProtKB:Q7Z5X2 xref: UniProtKB:Q8N6P4 xref: UniProtKB:Q9H4P5 xref: UniProtKB:Q9NRZ9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004799 ! HELLS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002162 name: RASF1_HUMAN def: "Ras association domain-containing protein 1" [UniProtKB:Q9NS23] xref: EMBL:AAB67312.1 xref: EMBL:AAC16001.1 xref: EMBL:AAC70910.2 xref: EMBL:AAD44174.1 xref: EMBL:AAD44175.1 xref: EMBL:AAD44176.1 xref: EMBL:AAF35127.2 xref: EMBL:AAF35128.2 xref: EMBL:AAF35129.2 xref: EMBL:AAG10038.1 xref: EMBL:AAG10064.1 xref: UniProtKB:O14571 xref: UniProtKB:O60539 xref: UniProtKB:O60710 xref: UniProtKB:Q9HB04 xref: UniProtKB:Q9HB18 xref: UniProtKB:Q9NS22 xref: UniProtKB:Q9NS23 xref: UniProtKB:Q9UND4 xref: UniProtKB:Q9UND5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005429 ! RASSF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006011 ! rassf1-xpa physical interaction relationship: participates_in CCO:I0008495 ! rassf1-nudt10 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002165 name: KIF15_HUMAN def: "Kinesin-like protein KIF15" [UniProtKB:Q9NS87] synonym: "hKLP2" EXACT [UniProtKB:Q9NS87] synonym: "Kinesin-like protein 2" EXACT [UniProtKB:Q9NS87] synonym: "Kinesin-like protein 7" EXACT [UniProtKB:Q9NS87] synonym: "Serologically defined breast cancer antigen NY-BR-62" EXACT [UniProtKB:Q9NS87] xref: EMBL:AAG48261.1 xref: EMBL:AAI17175.1 xref: EMBL:BAB03309.1 xref: EMBL:BAB55389.1 xref: EMBL:CAH10635.1 xref: UniProtKB:Q17RV9 xref: UniProtKB:Q69YL6 xref: UniProtKB:Q96JX7 xref: UniProtKB:Q9H280 xref: UniProtKB:Q9NS87 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006053 ! KIF15_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008016 ! kif15-kiaa1377 physical interaction relationship: participates_in CCO:I0008126 ! kif15-chd3 physical interaction relationship: participates_in CCO:I0008127 ! kif15-vim physical interaction relationship: participates_in CCO:I0008403 ! kif15-map1lc3a physical interaction relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002166 name: Q9NSH2_HUMAN def: "Septin" [UniProtKB:Q9NSH2] xref: EMBL:CAB89249.1 xref: UniProtKB:Q9NSH2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006054 ! DKFZp547B243_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002168 name: SMC4_HUMAN def: "Structural maintenance of chromosomes protein 4" [UniProtKB:Q9NTJ3] synonym: "Chromosome-associated polypeptide C" EXACT [UniProtKB:Q9NTJ3] synonym: "hCAP-C" EXACT [UniProtKB:Q9NTJ3] synonym: "XCAP-C homolog" EXACT [UniProtKB:Q9NTJ3] xref: EMBL:AAC72361.1 xref: EMBL:BAA73535.1 xref: EMBL:CAB66811.1 xref: EMBL:CAD38803.1 xref: EMBL:EAW78639.1 xref: UniProtKB:A6NLT9 xref: UniProtKB:O95752 xref: UniProtKB:Q8NDL4 xref: UniProtKB:Q9NTJ3 xref: UniProtKB:Q9UNT9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005629 ! SMC4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006364 ! ikbkg-smc4l1 physical interaction relationship: participates_in CCO:I0007038 ! smc2l1-smc4l1 physical interaction relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: transforms_into CCO:B0014082 ! SMC4_HUMAN-Phosphoserine22 relationship: transforms_into CCO:B0014083 ! SMC4_HUMAN-Phosphoserine28 relationship: transforms_into CCO:B0014084 ! SMC4_HUMAN-Phosphoserine41 relationship: transforms_into CCO:B0014085 ! SMC4_HUMAN-Phosphoserine1056 [Term] id: CCO:B0002169 name: SEP11_HUMAN def: "Septin-11" [UniProtKB:Q9NVA2] xref: EMBL:AAH08083.3 xref: EMBL:AAH63615.1 xref: EMBL:BAA91853.1 xref: EMBL:BAB55250.1 xref: UniProtKB:Q7L4N1 xref: UniProtKB:Q96SP1 xref: UniProtKB:Q9NVA2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005582 ! SEPT11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006897 ! sept5-sept11 physical interaction relationship: participates_in CCO:I0006899 ! sept11-sept5 physical interaction relationship: participates_in CCO:I0007372 ! sept5-sept11-1 physical interaction relationship: participates_in CCO:I0007376 ! sept11-sept5-1 physical interaction relationship: participates_in CCO:I0007794 ! sept5-sept11-2 direct interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013990 ! SEP11_HUMAN-N-acetylalanine2 [Term] id: CCO:B0002170 name: FANCI_HUMAN def: "Fanconi anemia group I protein" [UniProtKB:Q9NVI1] synonym: "Protein FANCI" EXACT [UniProtKB:Q9NVI1] xref: EMBL:AAH04277.1 xref: EMBL:BAA91770.1 xref: EMBL:BAB47423.1 xref: EMBL:BAB55200.1 xref: UniProtKB:Q96JN1 xref: UniProtKB:Q96ST0 xref: UniProtKB:Q9BT96 xref: UniProtKB:Q9NVI1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004612 ! FANCI_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011844 ! FANCI_HUMAN-Phosphoserine407 relationship: transforms_into CCO:B0011845 ! FANCI_HUMAN-Phosphoserine556 relationship: transforms_into CCO:B0011846 ! FANCI_HUMAN-Phosphoserine730 relationship: transforms_into CCO:B0011847 ! FANCI_HUMAN-Phosphothreonine952 relationship: transforms_into CCO:B0011848 ! FANCI_HUMAN-Phosphoserine1121 [Term] id: CCO:B0002171 name: AKIP_HUMAN def: "Aurora kinase A-interacting protein" [UniProtKB:Q9NWT8] synonym: "AURKA-interacting protein" EXACT [UniProtKB:Q9NWT8] xref: EMBL:AAH22808.1 xref: EMBL:AAH62333.1 xref: EMBL:BAA91289.1 xref: EMBL:CAI23191.1 xref: UniProtKB:Q5TA36 xref: UniProtKB:Q8TBD3 xref: UniProtKB:Q9NWT8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004044 ! AURKAIP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006704 ! akip-stk6-1 physical interaction relationship: participates_in CCO:I0007077 ! akip-stk6-2 physical interaction relationship: participates_in CCO:P0000250 ! negative regulation of mitosis [Term] id: CCO:B0002172 name: TXN4B_HUMAN def: "Thioredoxin-like protein 4B" [UniProtKB:Q9NX01] synonym: "Dim1-like protein" EXACT [UniProtKB:Q9NX01] xref: EMBL:AAH09646.1 xref: EMBL:AAS68520.1 xref: EMBL:BAA91224.1 xref: EMBL:CAG33521.1 xref: UniProtKB:Q9NX01 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005848 ! TXNL4B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000283 ! spliceosome relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002173 name: NDE1_HUMAN def: "Nuclear distribution protein nudE homolog 1" [UniProtKB:Q9NXR1] synonym: "NudE" EXACT [UniProtKB:Q9NXR1] xref: EMBL:AAH01421.1 xref: EMBL:AAH33900.1 xref: EMBL:BAA90949.1 xref: UniProtKB:Q49AQ2 xref: UniProtKB:Q9NXR1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005163 ! NDE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000300 ! centrosome duplication relationship: transforms_into CCO:B0013130 ! NDE1_HUMAN-Phosphothreonine246 relationship: transforms_into CCO:B0013131 ! NDE1_HUMAN-Phosphotyrosine279 relationship: transforms_into CCO:B0013132 ! NDE1_HUMAN-Phosphoserine282 relationship: transforms_into CCO:B0013133 ! NDE1_HUMAN-Phosphoserine306 relationship: transforms_into CCO:B0013134 ! NDE1_HUMAN-Phosphoserine307 [Term] id: CCO:B0002174 name: BTG4_HUMAN def: "Protein BTG4" [UniProtKB:Q9NY30] synonym: "PC3b" EXACT [UniProtKB:Q9NY30] xref: EMBL:CAB69821.1 xref: UniProtKB:Q9NY30 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004197 ! BTG4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002175 name: NSMA2_HUMAN def: "Sphingomyelin phosphodiesterase 3" [UniProtKB:Q9NY59] synonym: "EC 3.1.4.12" EXACT [UniProtKB:Q9NY59] synonym: "Neutral sphingomyelinase 2" EXACT [UniProtKB:Q9NY59] synonym: "Neutral sphingomyelinase II" EXACT [UniProtKB:Q9NY59] synonym: "nSMase-2" EXACT [UniProtKB:Q9NY59] synonym: "nSMase2" EXACT [UniProtKB:Q9NY59] xref: EMBL:AAI12239.1 xref: EMBL:CAB92964.1 xref: UniProtKB:Q2M1S8 xref: UniProtKB:Q9NY59 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005217 ! SMPD3_human relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0001127 ! sphingomyelin phosphodiesterase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000021 ! Golgi membrane relationship: located_in CCO:C0000244 ! membrane fraction relationship: located_in CCO:C0000375 ! Golgi apparatus relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: participates_in CCO:I0008235 ! smpd3-med31 physical interaction relationship: participates_in CCO:I0008236 ! smpd3-cops6 physical interaction relationship: participates_in CCO:I0008237 ! smpd3-crmp1 physical interaction relationship: participates_in CCO:I0008238 ! smpd3-dkfzp564o0523 physical interaction relationship: participates_in CCO:I0008239 ! smpd3-g22p1 physical interaction relationship: participates_in CCO:I0008240 ! smpd3-gdf9 physical interaction relationship: participates_in CCO:I0008241 ! smpd3-rif1 physical interaction relationship: participates_in CCO:I0008242 ! smpd3-setdb1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002176 name: SPHK1_HUMAN def: "Sphingosine kinase 1" [UniProtKB:Q9NYA1] synonym: "EC 2.7.1.91" EXACT [UniProtKB:Q9NYA1] synonym: "SK 1" EXACT [UniProtKB:Q9NYA1] synonym: "SPK 1" EXACT [UniProtKB:Q9NYA1] xref: EMBL:AAF73423.1 xref: EMBL:AAF73470.1 xref: EMBL:AAG01980.1 xref: EMBL:BAB14028.1 xref: EMBL:BAB14558.1 xref: EMBL:CAB92131.1 xref: UniProtKB:Q9HD92 xref: UniProtKB:Q9NY70 xref: UniProtKB:Q9NYA1 xref: UniProtKB:Q9NYL3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005660 ! SPHK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000259 ! positive regulation of mitotic cell cycle [Term] id: CCO:B0002177 name: APC11_HUMAN def: "Anaphase-promoting complex subunit 11" [UniProtKB:Q9NYG5] synonym: "APC11" EXACT [UniProtKB:Q9NYG5] synonym: "Cyclosome subunit 11" EXACT [UniProtKB:Q9NYG5] synonym: "Hepatocellular carcinoma-associated RING finger protein" EXACT [UniProtKB:Q9NYG5] xref: EMBL:AAF36134.1 xref: EMBL:AAF65816.1 xref: EMBL:AAH00607.2 xref: EMBL:AAH66308.1 xref: EMBL:AAH95454.1 xref: EMBL:AAI04642.1 xref: EMBL:AAL95694.1 xref: UniProtKB:Q502X9 xref: UniProtKB:Q9BW64 xref: UniProtKB:Q9NYG5 xref: UniProtKB:Q9P0R2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004079 ! ANAPC11_human relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000282 ! anaphase-promoting complex relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0002178 name: MLTK_HUMAN def: "Mitogen-activated protein kinase kinase kinase MLT" [UniProtKB:Q9NYL2] synonym: "Cervical cancer suppressor gene 4 protein" EXACT [UniProtKB:Q9NYL2] synonym: "EC 2.7.11.25" EXACT [UniProtKB:Q9NYL2] synonym: "HCCS-4" EXACT [UniProtKB:Q9NYL2] synonym: "Leucine zipper- and sterile alpha motif-containing kinase" EXACT [UniProtKB:Q9NYL2] synonym: "Mixed lineage kinase-related kinase" EXACT [UniProtKB:Q9NYL2] synonym: "MLK-like mitogen-activated protein triple kinase" EXACT [UniProtKB:Q9NYL2] synonym: "MLK-related kinase" EXACT [UniProtKB:Q9NYL2] synonym: "MRK" EXACT [UniProtKB:Q9NYL2] synonym: "Sterile alpha motif- and leucine zipper-containing kinase AZK" EXACT [UniProtKB:Q9NYL2] xref: EMBL:AAF63490.1 xref: EMBL:AAF65822.1 xref: EMBL:AAH01401.1 xref: EMBL:AAK11615.1 xref: EMBL:AAL85891.1 xref: EMBL:AAL85892.1 xref: EMBL:AAO33376.1 xref: EMBL:AAX82002.1 xref: EMBL:AAX93067.1 xref: EMBL:BAB12040.1 xref: EMBL:BAB16444.1 xref: EMBL:BAB16445.1 xref: EMBL:BAD92211.1 xref: UniProtKB:Q53SX1 xref: UniProtKB:Q580W8 xref: UniProtKB:Q59GY5 xref: UniProtKB:Q86YW8 xref: UniProtKB:Q9HCC4 xref: UniProtKB:Q9HCC5 xref: UniProtKB:Q9HDD2 xref: UniProtKB:Q9NYE9 xref: UniProtKB:Q9NYL2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005105 ! MLTK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005850 ! mltk-znf567 physical interaction relationship: participates_in CCO:I0007864 ! mltk-mltk-1 acetylation relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: participates_in CCO:P0000008 ! DNA damage checkpoint relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0012964 ! MLTK_HUMAN-Phosphothreonine161 relationship: transforms_into CCO:B0012965 ! MLTK_HUMAN-Phosphoserine165 relationship: transforms_into CCO:B0012966 ! MLTK_HUMAN-Phosphoserine635 relationship: transforms_into CCO:B0012967 ! MLTK_HUMAN-Phosphoserine637 relationship: transforms_into CCO:B0012968 ! MLTK_HUMAN-Phosphothreonine639 relationship: transforms_into CCO:B0036016 ! MLTK_HUMAN-Phosphoserine633 [Term] id: CCO:B0002180 name: GTSE1_HUMAN def: "G2 and S phase-expressed protein 1" [UniProtKB:Q9NYZ3] synonym: "B99 homolog" EXACT [UniProtKB:Q9NYZ3] xref: EMBL:AAF31459.1 xref: EMBL:AAH06325.1 xref: EMBL:AAH75828.1 xref: EMBL:BAD96526.1 xref: EMBL:CAI18789.1 xref: EMBL:CAI19318.1 xref: UniProtKB:Q53GX5 xref: UniProtKB:Q5R3I6 xref: UniProtKB:Q6DHX4 xref: UniProtKB:Q9BRE0 xref: UniProtKB:Q9NYZ3 xref: UniProtKB:Q9UGZ9 xref: UniProtKB:Q9Y557 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004739 ! GTSE1_human relationship: has_function CCO:F0000272 ! molecular_function relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000434 ! microtubule relationship: located_in CCO:C0000439 ! cytoplasmic microtubule relationship: participates_in CCO:P0000015 ! G2 phase of mitotic cell cycle relationship: participates_in CCO:P0000065 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest relationship: transforms_into CCO:B0011990 ! GTSE1_HUMAN-Phosphoserine168 relationship: transforms_into CCO:B0011991 ! GTSE1_HUMAN-Phosphoserine494 relationship: transforms_into CCO:B0011992 ! GTSE1_HUMAN-Phosphoserine495 relationship: transforms_into CCO:B0011993 ! GTSE1_HUMAN-Phosphoserine501 relationship: transforms_into CCO:B0011994 ! GTSE1_HUMAN-Phosphoserine504 relationship: transforms_into CCO:B0011995 ! GTSE1_HUMAN-Phosphoserine536 relationship: transforms_into CCO:B0011996 ! GTSE1_HUMAN-Phosphoserine575 relationship: transforms_into CCO:B0011997 ! GTSE1_HUMAN-Phosphoserine580 relationship: transforms_into CCO:B0011998 ! GTSE1_HUMAN-Phosphoserine592 [Term] id: CCO:B0002181 name: WWOX_HUMAN def: "WW domain-containing oxidoreductase" [UniProtKB:Q9NZC7] synonym: "EC 1.1.1.-" EXACT [UniProtKB:Q9NZC7] synonym: "Fragile site FRA16D oxidoreductase" EXACT [UniProtKB:Q9NZC7] xref: EMBL:AAF27049.1 xref: EMBL:AAF27050.1 xref: EMBL:AAF78197.1 xref: EMBL:AAF82053.1 xref: EMBL:AAF82054.1 xref: EMBL:AAF82055.1 xref: EMBL:AAF82056.1 xref: EMBL:AAH03184.1 xref: EMBL:AAK81727.1 xref: EMBL:AAK81728.1 xref: EMBL:AAL05449.1 xref: EMBL:AAL05450.1 xref: EMBL:AAL05451.1 xref: EMBL:AAP36113.1 xref: EMBL:AAP94227.1 xref: UniProtKB:Q5MYT5 xref: UniProtKB:Q96KM3 xref: UniProtKB:Q96RF2 xref: UniProtKB:Q9BTT8 xref: UniProtKB:Q9NPC9 xref: UniProtKB:Q9NRF4 xref: UniProtKB:Q9NRF5 xref: UniProtKB:Q9NRF6 xref: UniProtKB:Q9NRK1 xref: UniProtKB:Q9NZC5 xref: UniProtKB:Q9NZC7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005936 ! WWOX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0014703 ! WWOX_HUMAN-Phosphoserine14 relationship: transforms_into CCO:B0014704 ! WWOX_HUMAN-Phosphotyrosine33 [Term] id: CCO:B0002182 name: SH3B4_HUMAN def: "SH3 domain-binding protein 4" [UniProtKB:Q9P0V3] synonym: "EH-binding protein 10" EXACT [UniProtKB:Q9P0V3] synonym: "Transferrin receptor-trafficking protein" EXACT [UniProtKB:Q9P0V3] xref: EMBL:AAD01551.1 xref: EMBL:AAF33022.1 xref: EMBL:AAH57396.1 xref: EMBL:AAY14916.1 xref: EMBL:AAY24025.1 xref: EMBL:ABB18377.1 xref: UniProtKB:O95082 xref: UniProtKB:Q309A3 xref: UniProtKB:Q53QD0 xref: UniProtKB:Q53TD1 xref: UniProtKB:Q9P0V3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005606 ! SH3BP4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014052 ! SH3B4_HUMAN-Phosphoserine637 [Term] id: CCO:B0002183 name: SEP10_HUMAN def: "Septin-10" [UniProtKB:Q9P0V9] xref: EMBL:AAF67469.1 xref: EMBL:AAH20502.1 xref: EMBL:AAH50345.2 xref: EMBL:AAY24142.1 xref: EMBL:BAB13873.1 xref: UniProtKB:Q86VP5 xref: UniProtKB:Q9HAH6 xref: UniProtKB:Q9P0V9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005581 ! SEPT10_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002184 name: HM20B_HUMAN def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related" [UniProtKB:Q9P0W2] synonym: "BRCA2-associated factor 35" EXACT [UniProtKB:Q9P0W2] synonym: "HMG box-containing protein 20B" EXACT [UniProtKB:Q9P0W2] synonym: "SMARCE1-related protein" EXACT [UniProtKB:Q9P0W2] synonym: "Sox-like transcriptional factor" EXACT [UniProtKB:Q9P0W2] synonym: "Structural DNA-binding protein BRAF35" EXACT [UniProtKB:Q9P0W2] xref: EMBL:AAC26860.1 xref: EMBL:AAC62837.1 xref: EMBL:AAF66707.1 xref: EMBL:AAF76253.1 xref: EMBL:AAG01174.1 xref: EMBL:AAG60060.1 xref: EMBL:AAH02552.1 xref: EMBL:AAH03505.2 xref: EMBL:AAH04408.2 xref: EMBL:AAH21585.1 xref: EMBL:BAC03510.1 xref: EMBL:CAB90809.2 xref: EMBL:CAG33035.1 xref: UniProtKB:Q6IBP8 xref: UniProtKB:Q8NBD5 xref: UniProtKB:Q9HD21 xref: UniProtKB:Q9P0W2 xref: UniProtKB:Q9Y491 xref: UniProtKB:Q9Y4A2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004811 ! HMG20B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008118 ! hmg20b-vim physical interaction relationship: participates_in CCO:I0008395 ! hmg20b-hnrpl physical interaction relationship: participates_in CCO:I0008396 ! hmg20b-tacc2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002185 name: PIM2_HUMAN def: "Serine/threonine-protein kinase Pim-2" [UniProtKB:Q9P1W9] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9P1W9] synonym: "Pim-2h" EXACT [UniProtKB:Q9P1W9] xref: EMBL:AAC78506.1 xref: EMBL:AAH18111.1 xref: EMBL:BAA95613.1 xref: UniProtKB:Q99739 xref: UniProtKB:Q9P1W9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005315 ! PIM2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005760 ! cutc-pim2 physical interaction relationship: participates_in CCO:I0006647 ! pim2-atxn1 physical interaction relationship: participates_in CCO:I0008397 ! hnrph3-pim2 physical interaction relationship: participates_in CCO:I0008412 ! ndufb8-pim2 physical interaction relationship: participates_in CCO:I0008473 ! fbxo18-pim2 physical interaction relationship: participates_in CCO:I0008501 ! rpl21-pim2 physical interaction relationship: participates_in CCO:P0000131 ! male meiosis relationship: transforms_into CCO:B0013512 ! PIM2_HUMAN-Phosphothreonine195 relationship: transforms_into CCO:B0013513 ! PIM2_HUMAN-Phosphoserine204 [Term] id: CCO:B0002186 name: RCC2_HUMAN def: "Protein RCC2" [UniProtKB:Q9P258] synonym: "RCC1-like protein TD-60" EXACT [UniProtKB:Q9P258] synonym: "Telophase disk protein of 60 kDa" EXACT [UniProtKB:Q9P258] xref: EMBL:AAH04933.1 xref: EMBL:AAH42141.1 xref: EMBL:AAH53908.1 xref: EMBL:BAA95994.1 xref: EMBL:CAB94882.1 xref: EMBL:CAD13148.1 xref: UniProtKB:Q8IVL9 xref: UniProtKB:Q9BSN6 xref: UniProtKB:Q9NPV8 xref: UniProtKB:Q9P258 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005457 ! RCC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013810 ! RCC2_HUMAN-Phosphothreonine20 relationship: transforms_into CCO:B0013811 ! RCC2_HUMAN-Phosphoserine43 relationship: transforms_into CCO:B0013812 ! RCC2_HUMAN-Phosphoserine44 relationship: transforms_into CCO:B0013813 ! RCC2_HUMAN-Phosphoserine45 relationship: transforms_into CCO:B0013814 ! RCC2_HUMAN-Phosphoserine46 relationship: transforms_into CCO:B0013815 ! RCC2_HUMAN-Phosphoserine50 relationship: transforms_into CCO:B0013816 ! RCC2_HUMAN-Phosphoserine51 relationship: transforms_into CCO:B0013817 ! RCC2_HUMAN-Phosphoserine347 [Term] id: CCO:B0002187 name: BCCIP_HUMAN def: "BRCA2 and CDKN1A-interacting protein" [UniProtKB:Q9P287] synonym: "Protein TOK-1" EXACT [UniProtKB:Q9P287] xref: EMBL:AAH09771.1 xref: EMBL:AAL55436.1 xref: EMBL:AAL55438.1 xref: EMBL:AAL55439.1 xref: EMBL:AAL55440.1 xref: EMBL:BAA92927.1 xref: EMBL:BAA92928.1 xref: EMBL:CAD39118.1 xref: EMBL:CAI12091.1 xref: EMBL:CAI12092.1 xref: EMBL:CAI12093.1 xref: UniProtKB:Q8ND15 xref: UniProtKB:Q96GC4 xref: UniProtKB:Q9P287 xref: UniProtKB:Q9P288 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004149 ! BCCIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0010769 ! BCCIP_HUMAN-Phosphoserine12 relationship: transforms_into CCO:B0010770 ! BCCIP_HUMAN-Phosphoserine42 relationship: transforms_into CCO:B0010771 ! BCCIP_HUMAN-Phosphoserine112 relationship: transforms_into CCO:B0010772 ! BCCIP_HUMAN-Phosphoserine115 [Term] id: CCO:B0002188 name: RHG20_HUMAN def: "Rho GTPase-activating protein 20" [UniProtKB:Q9P2F6] synonym: "Rho-type GTPase-activating protein 20" EXACT [UniProtKB:Q9P2F6] xref: EMBL:AAH39340.1 xref: EMBL:AAS45466.1 xref: EMBL:AAS45467.1 xref: EMBL:AAS45468.1 xref: EMBL:AAS45469.1 xref: EMBL:AAS45470.1 xref: EMBL:BAA92629.1 xref: UniProtKB:Q6RJU1 xref: UniProtKB:Q6RJU2 xref: UniProtKB:Q6RJU3 xref: UniProtKB:Q6RJU5 xref: UniProtKB:Q8IXS1 xref: UniProtKB:Q9P2F6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005483 ! ARHGAP20_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002189 name: DEC1_HUMAN def: "Deleted in esophageal cancer 1" [UniProtKB:Q9P2X7] synonym: "Candidate tumor suppressor CTS9" EXACT [UniProtKB:Q9P2X7] xref: EMBL:BAA96242.1 xref: EMBL:CAI16660.1 xref: UniProtKB:Q9P2X7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004461 ! DEC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002192 name: HDAC6_HUMAN def: "Histone deacetylase 6" [UniProtKB:Q9UBN7] synonym: "EC 3.5.1.98" EXACT [UniProtKB:Q9UBN7] synonym: "HD6" EXACT [UniProtKB:Q9UBN7] xref: EMBL:AAD29048.1 xref: EMBL:CAA09893.1 xref: UniProtKB:Q9UBN7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004791 ! HDAC6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006437 ! relb-hdac6 physical interaction relationship: participates_in CCO:I0006505 ! q9btt4-q71f56-1 physical interaction relationship: participates_in CCO:I0006506 ! q9nwa0-q71f56-1 physical interaction relationship: participates_in CCO:I0006513 ! sirt2-hdac6-2 colocalization relationship: participates_in CCO:I0006708 ! sirt2-hdac6-1 physical interaction relationship: participates_in CCO:I0006825 ! brms1-hdac6 physical interaction relationship: participates_in CCO:I0006950 ! hdac6-hdac11-1 physical interaction relationship: participates_in CCO:I0007194 ! hdac6-brms1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0012168 ! HDAC6_HUMAN-Phosphoserine22 relationship: transforms_into CCO:B0012169 ! HDAC6_HUMAN-Phosphothreonine30 [Term] id: CCO:B0002194 name: DBF4A_HUMAN def: "Protein DBF4 homolog A" [UniProtKB:Q9UBU7] synonym: "Activator of S phase kinase" EXACT [UniProtKB:Q9UBU7] synonym: "Chiffon homolog A" EXACT [UniProtKB:Q9UBU7] synonym: "DBF4-type zinc finger-containing protein 1" EXACT [UniProtKB:Q9UBU7] xref: EMBL:AAD41911.1 xref: EMBL:AAD45357.1 xref: EMBL:AAH36045.1 xref: EMBL:AAH47693.1 xref: EMBL:AAS07418.1 xref: EMBL:AAS07442.1 xref: EMBL:BAA78326.1 xref: EMBL:BAA78327.1 xref: EMBL:BAF85258.1 xref: EMBL:EAL24170.1 xref: EMBL:EAW76930.1 xref: UniProtKB:A4D1D8 xref: UniProtKB:A8K954 xref: UniProtKB:O75226 xref: UniProtKB:Q75MS6 xref: UniProtKB:Q75N01 xref: UniProtKB:Q9UBU7 xref: UniProtKB:Q9Y2M6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004441 ! DBF4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006497 ! lsm8-ask/h37_(hudbf4 physical interaction relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0032839 ! DBF4A_HUMAN-Phosphoserine381 relationship: transforms_into CCO:B0032840 ! DBF4A_HUMAN-Phosphothreonine535 relationship: transforms_into CCO:B0032841 ! DBF4A_HUMAN-Phosphoserine539 [Term] id: CCO:B0002196 name: DAXX_HUMAN def: "Death domain-associated protein 6" [UniProtKB:Q9UER7] synonym: "Daxx" EXACT [UniProtKB:Q9UER7] synonym: "EAP1" EXACT [UniProtKB:Q9UER7] synonym: "ETS1-associated protein 1" EXACT [UniProtKB:Q9UER7] synonym: "Fas death domain-associated protein" EXACT [UniProtKB:Q9UER7] synonym: "hDaxx" EXACT [UniProtKB:Q9UER7] xref: EMBL:AAB63043.1 xref: EMBL:AAB66585.2 xref: EMBL:AAB92671.1 xref: EMBL:AAC39853.1 xref: EMBL:AAC72843.1 xref: EMBL:AAH00220.1 xref: EMBL:BAA34295.1 xref: EMBL:CAB09986.2 xref: EMBL:CAB09989.2 xref: UniProtKB:O14747 xref: UniProtKB:O15141 xref: UniProtKB:O15208 xref: UniProtKB:Q9BWI3 xref: UniProtKB:Q9UER7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004437 ! DAXX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006222 ! ubp7-daxx physical interaction relationship: participates_in CCO:I0006947 ! daxx-pml-2 colocalization relationship: participates_in CCO:I0007065 ! pml-daxx-1 physical interaction relationship: participates_in CCO:I0007066 ! daxx-pml-1 physical interaction relationship: participates_in CCO:I0007811 ! mdm2-daxx-2 physical interaction relationship: transforms_into CCO:B0011428 ! DAXX_HUMAN-Phosphoserine213 relationship: transforms_into CCO:B0011429 ! DAXX_HUMAN-Phosphothreonine459 relationship: transforms_into CCO:B0011430 ! DAXX_HUMAN-Phosphoserine495 relationship: transforms_into CCO:B0011431 ! DAXX_HUMAN-Phosphotyrosine648 relationship: transforms_into CCO:B0011432 ! DAXX_HUMAN-Phosphoserine668 relationship: transforms_into CCO:B0011433 ! DAXX_HUMAN-Phosphoserine671 relationship: transforms_into CCO:B0011434 ! DAXX_HUMAN-Phosphothreonine709 relationship: transforms_into CCO:B0011435 ! DAXX_HUMAN-Phosphoserine712 relationship: transforms_into CCO:B0011436 ! DAXX_HUMAN-Phosphoserine737 relationship: transforms_into CCO:B0011437 ! DAXX_HUMAN-Phosphoserine739 [Term] id: CCO:B0002197 name: DMBT1_HUMAN def: "Deleted in malignant brain tumors 1 protein precursor" [UniProtKB:Q9UGM3] synonym: "Glycoprotein 340" EXACT [UniProtKB:Q9UGM3] synonym: "Gp-340" EXACT [UniProtKB:Q9UGM3] synonym: "Surfactant pulmonary-associated D-binding protein" EXACT [UniProtKB:Q9UGM3] xref: EMBL:AAD49696.1 xref: EMBL:BAA78577.1 xref: EMBL:BAD92928.1 xref: EMBL:CAA04019.1 xref: EMBL:CAB56155.1 xref: EMBL:CAB63941.1 xref: EMBL:CAB63942.1 xref: EMBL:CAC44122.1 xref: EMBL:CAE45995.1 xref: EMBL:CAI14487.1 xref: EMBL:CAI14488.1 xref: EMBL:CAI14495.1 xref: EMBL:CAI14496.1 xref: UniProtKB:Q59EX0 xref: UniProtKB:Q5JR26 xref: UniProtKB:Q6MZN4 xref: UniProtKB:Q96DU4 xref: UniProtKB:Q9UGM2 xref: UniProtKB:Q9UGM3 xref: UniProtKB:Q9UJ57 xref: UniProtKB:Q9UKJ4 xref: UniProtKB:Q9Y211 xref: UniProtKB:Q9Y4V9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004484 ! DMBT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002198 name: SEPT3_HUMAN def: "Neuronal-specific septin-3" [UniProtKB:Q9UH03] xref: EMBL:AAG00517.1 xref: EMBL:AAG00518.1 xref: EMBL:AAG00519.1 xref: EMBL:AAI11780.2 xref: EMBL:BAD92389.1 xref: EMBL:CAD38797.1 xref: EMBL:CAG30458.1 xref: EMBL:CAI41693.1 xref: UniProtKB:Q2NKJ7 xref: UniProtKB:Q59GF7 xref: UniProtKB:Q6IBZ6 xref: UniProtKB:Q8N3P3 xref: UniProtKB:Q9HD35 xref: UniProtKB:Q9UH03 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005586 ! SEPT3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008505 ! sept3-wbp2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0013994 ! SEPT3_HUMAN-Phosphoserine91 [Term] id: CCO:B0002199 name: UN84B_HUMAN def: "Protein unc-84 homolog B" [UniProtKB:Q9UH99] synonym: "Rab5-interacting protein" EXACT [UniProtKB:Q9UH99] synonym: "Rab5IP" EXACT [UniProtKB:Q9UH99] synonym: "Sad1/unc-84 protein-like 2" EXACT [UniProtKB:Q9UH99] xref: EMBL:AAF15887.1 xref: EMBL:AAH30684.2 xref: EMBL:AAI11718.1 xref: EMBL:AAT90500.1 xref: EMBL:BAA31643.1 xref: EMBL:CAD97926.1 xref: EMBL:CAG30360.1 xref: EMBL:CAI21604.1 xref: UniProtKB:O75156 xref: UniProtKB:Q2NKN8 xref: UniProtKB:Q6B4H1 xref: UniProtKB:Q7Z3E3 xref: UniProtKB:Q9UH99 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005884 ! UNC84B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000068 ! mitotic spindle organization and biogenesis relationship: transforms_into CCO:B0014581 ! UN84B_HUMAN-Phosphoserine12 relationship: transforms_into CCO:B0014582 ! UN84B_HUMAN-Phosphoserine38 relationship: transforms_into CCO:B0014583 ! UN84B_HUMAN-Phosphoserine54 relationship: transforms_into CCO:B0014584 ! UN84B_HUMAN-Phosphoserine116 [Term] id: CCO:B0002200 name: MLH3_HUMAN def: "DNA mismatch repair protein Mlh3" [UniProtKB:Q9UHC1] synonym: "MutL protein homolog 3" EXACT [UniProtKB:Q9UHC1] xref: EMBL:AAC42005.1 xref: EMBL:AAF23904.1 xref: EMBL:AAF23905.1 xref: EMBL:AAX59030.1 xref: EMBL:BAA92353.1 xref: UniProtKB:P49751 xref: UniProtKB:Q56DK9 xref: UniProtKB:Q9P292 xref: UniProtKB:Q9UHC0 xref: UniProtKB:Q9UHC1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005101 ! MLH3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000122 ! meiotic recombination relationship: transforms_into CCO:B0036014 ! MLH3_HUMAN-Phosphothreonine606 relationship: transforms_into CCO:B0036015 ! MLH3_HUMAN-Phosphothreonine610 [Term] id: CCO:B0002201 name: SEPT9_HUMAN def: "Septin-9" [UniProtKB:Q9UHD8] synonym: "MLL septin-like fusion protein" EXACT [UniProtKB:Q9UHD8] synonym: "MLL septin-like fusion protein MSF-A" EXACT [UniProtKB:Q9UHD8] synonym: "Ov/Br septin" EXACT [UniProtKB:Q9UHD8] synonym: "Ovarian/Breast septin" EXACT [UniProtKB:Q9UHD8] synonym: "Septin D1" EXACT [UniProtKB:Q9UHD8] xref: EMBL:AAD39749.1 xref: EMBL:AAF23373.1 xref: EMBL:AAF23374.1 xref: EMBL:AAG27919.1 xref: EMBL:AAH21192.1 xref: EMBL:AAH54004.1 xref: EMBL:AAP35879.1 xref: EMBL:BAA76835.2 xref: EMBL:BAB14057.1 xref: EMBL:CAB45728.1 xref: EMBL:CAC42221.1 xref: EMBL:CAC42222.1 xref: EMBL:CAC42223.1 xref: EMBL:CAC42224.1 xref: UniProtKB:Q96QF3 xref: UniProtKB:Q96QF4 xref: UniProtKB:Q96QF5 xref: UniProtKB:Q9HA04 xref: UniProtKB:Q9UG40 xref: UniProtKB:Q9UHD8 xref: UniProtKB:Q9Y5W4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005592 ! SEPT9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0014010 ! SEPT9_HUMAN-Phosphoserine30 relationship: transforms_into CCO:B0014011 ! SEPT9_HUMAN-Phosphothreonine42 relationship: transforms_into CCO:B0014012 ! SEPT9_HUMAN-Phosphothreonine49 relationship: transforms_into CCO:B0014013 ! SEPT9_HUMAN-Phosphoserine82 relationship: transforms_into CCO:B0014014 ! SEPT9_HUMAN-Phosphoserine85 relationship: transforms_into CCO:B0014015 ! SEPT9_HUMAN-Phosphoserine89 relationship: transforms_into CCO:B0014016 ! SEPT9_HUMAN-Phosphothreonine142 [Term] id: CCO:B0002202 name: SRTD1_HUMAN def: "SERTA domain-containing protein 1" [UniProtKB:Q9UHV2] synonym: "CDK4-binding protein p34SEI1" EXACT [UniProtKB:Q9UHV2] synonym: "SEI-1" EXACT [UniProtKB:Q9UHV2] synonym: "Transcriptional regulator interacting with the PHD-bromodomain 1" EXACT [UniProtKB:Q9UHV2] synonym: "TRIP-Br1" EXACT [UniProtKB:Q9UHV2] xref: EMBL:AAF08349.1 xref: EMBL:AAH02670.1 xref: EMBL:AAK52831.1 xref: EMBL:AAM77800.1 xref: UniProtKB:Q9BUE7 xref: UniProtKB:Q9UHV2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005673 ! SERTAD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007627 ! atxn7l3-sertad1 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity [Term] id: CCO:B0002204 name: MD2L2_HUMAN def: "Mitotic spindle assembly checkpoint protein MAD2B" [UniProtKB:Q9UI95] synonym: "hREV7" EXACT [UniProtKB:Q9UI95] synonym: "MAD2-like 2" EXACT [UniProtKB:Q9UI95] xref: EMBL:AAD30290.1 xref: EMBL:AAD41647.1 xref: EMBL:AAF20267.1 xref: EMBL:AAF34357.1 xref: EMBL:AAH15244.1 xref: EMBL:AAY26393.1 xref: EMBL:CAI20218.1 xref: UniProtKB:Q5TGW7 xref: UniProtKB:Q9UI95 xref: UniProtKB:Q9UNA7 xref: UniProtKB:Q9Y6I6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005049 ! MAD2L2_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006043 ! adam9-mad2l2-3 physical interaction relationship: participates_in CCO:I0006628 ! adam9-mad2l2-2 physical interaction relationship: participates_in CCO:I0007286 ! adam9-mad2l2-1 physical interaction relationship: participates_in CCO:I0007337 ! bat2-mad2l2 physical interaction relationship: participates_in CCO:I0007391 ! adam15-mad2l2-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000105 ! mitotic cell cycle spindle assembly checkpoint [Term] id: CCO:B0002205 name: MUTYH_HUMAN def: "A/G-specific adenine DNA glycosylase" [UniProtKB:Q9UIF7] synonym: "EC 3.2.2.-" EXACT [UniProtKB:Q9UIF7] synonym: "hMYH" EXACT [UniProtKB:Q9UIF7] synonym: "MutY homolog" EXACT [UniProtKB:Q9UIF7] xref: EMBL:AAC50618.1 xref: EMBL:AAH03178.1 xref: EMBL:AAM78555.1 xref: EMBL:BAA89336.1 xref: EMBL:BAA89337.1 xref: EMBL:BAA89338.1 xref: EMBL:BAA89339.1 xref: EMBL:BAA89340.1 xref: EMBL:BAA89341.1 xref: EMBL:BAA89342.1 xref: EMBL:BAA89343.1 xref: EMBL:BAA89344.1 xref: EMBL:BAA89345.1 xref: EMBL:CAI21713.1 xref: EMBL:CAI21714.1 xref: EMBL:CAI21718.1 xref: EMBL:CAI21719.1 xref: EMBL:CAI21720.1 xref: UniProtKB:Q15830 xref: UniProtKB:Q9UBP2 xref: UniProtKB:Q9UBS7 xref: UniProtKB:Q9UIF4 xref: UniProtKB:Q9UIF5 xref: UniProtKB:Q9UIF6 xref: UniProtKB:Q9UIF7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005138 ! MUTYH_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0000916 ! endonuclease activity relationship: has_function CCO:F0001643 ! iron ion binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0003368 ! hydrolase activity, acting on glycosyl bonds relationship: has_function CCO:F0004051 ! DNA N-glycosylase activity relationship: has_function CCO:F0004987 ! MutSalpha complex binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_function CCO:F0008138 ! iron-sulfur cluster binding relationship: has_function CCO:F0008141 ! 4 iron, 4 sulfur cluster binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: participates_in CCO:I0008483 ! lrsam1-mutyh physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002206 name: HERC5_HUMAN def: "Probable E3 ubiquitin-protein ligase HERC5" [UniProtKB:Q9UII4] synonym: "Cyclin-E-binding protein 1" EXACT [UniProtKB:Q9UII4] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q9UII4] synonym: "HECT domain and RCC1-like domain-containing protein 5" EXACT [UniProtKB:Q9UII4] xref: EMBL:BAA88519.1 xref: UniProtKB:Q9UII4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004800 ! HERC5_human relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0003433 ! ligase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity [Term] id: CCO:B0002207 name: DUS13_HUMAN def: "Dual specificity protein phosphatase 13" [UniProtKB:Q9UII6] synonym: "Dual specificity phosphatase SKRP4" EXACT [UniProtKB:Q9UII6] synonym: "EC 3.1.3.16" EXACT [UniProtKB:Q9UII6] synonym: "EC 3.1.3.48" EXACT [UniProtKB:Q9UII6] synonym: "Testis- and skeletal-muscle-specific DSP" EXACT [UniProtKB:Q9UII6] xref: EMBL:AAH09778.1 xref: EMBL:BAA89412.1 xref: EMBL:BAD91014.1 xref: EMBL:CAI40905.1 xref: UniProtKB:Q5JSC6 xref: UniProtKB:Q96GC2 xref: UniProtKB:Q9UII6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004520 ! DUSP13_human relationship: has_function CCO:F0001086 ! phosphoprotein phosphatase activity relationship: has_function CCO:F0001090 ! protein tyrosine phosphatase activity relationship: has_function CCO:F0001741 ! protein tyrosine/serine/threonine phosphatase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0003362 ! phosphoric monoester hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0002208 name: KIF25_HUMAN def: "Kinesin-like protein KIF25" [UniProtKB:Q9UIL4] synonym: "Kinesin-like protein 3" EXACT [UniProtKB:Q9UIL4] xref: EMBL:BAA36417.1 xref: EMBL:BAA36418.1 xref: EMBL:CAI12327.1 xref: UniProtKB:O94775 xref: UniProtKB:Q5SZU9 xref: UniProtKB:Q9UIL4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004945 ! KIF25_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:B0002209 name: STAG3_HUMAN def: "Cohesin subunit SA-3" [UniProtKB:Q9UJ98] synonym: "SCC3 homolog 3" EXACT [UniProtKB:Q9UJ98] synonym: "Stromal antigen 3" EXACT [UniProtKB:Q9UJ98] synonym: "Stromalin 3" EXACT [UniProtKB:Q9UJ98] xref: EMBL:CAB59367.1 xref: EMBL:CAD38679.2 xref: UniProtKB:Q8NDP3 xref: UniProtKB:Q9UJ98 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005685 ! STAG3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000121 ! synaptonemal complex assembly [Term] id: CCO:B0002210 name: MCM8_HUMAN def: "DNA replication licensing factor MCM8" [UniProtKB:Q9UJA3] synonym: "Minichromosome maintenance 8" EXACT [UniProtKB:Q9UJA3] xref: EMBL:AAH08830.2 xref: EMBL:AAH80656.1 xref: EMBL:AAI01055.1 xref: EMBL:AAI01057.1 xref: EMBL:AAI01058.1 xref: EMBL:AAO21222.1 xref: EMBL:BAB55260.1 xref: EMBL:CAB55276.2 xref: EMBL:CAD27750.1 xref: EMBL:CAI23480.1 xref: UniProtKB:Q495R4 xref: UniProtKB:Q495R7 xref: UniProtKB:Q86US4 xref: UniProtKB:Q969I5 xref: UniProtKB:Q9UJA3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005043 ! MCM8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002211 name: TBE_HUMAN def: "Tubulin epsilon chain" [UniProtKB:Q9UJT0] synonym: "Epsilon-tubulin" EXACT [UniProtKB:Q9UJT0] xref: EMBL:AAF09585.1 xref: EMBL:AAH25405.1 xref: EMBL:AAH31101.1 xref: UniProtKB:Q8NEG3 xref: UniProtKB:Q9UJT0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005739 ! TUBE1_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000427 ! GTPase activity relationship: has_function CCO:F0001484 ! structural molecule activity relationship: has_function CCO:F0001486 ! structural constituent of cytoskeleton relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000043 ! pericentriolar material relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000434 ! microtubule relationship: located_in CCO:C0001750 ! protein complex relationship: participates_in CCO:P0000108 ! centrosome cycle [Term] id: CCO:B0002212 name: CDC23_HUMAN def: "Cell division cycle protein 23 homolog" [UniProtKB:Q9UJX2] synonym: "Anaphase-promoting complex subunit 8" EXACT [UniProtKB:Q9UJX2] synonym: "APC8" EXACT [UniProtKB:Q9UJX2] synonym: "Cyclosome subunit 8" EXACT [UniProtKB:Q9UJX2] xref: EMBL:AAC70920.1 xref: EMBL:AAF05755.1 xref: EMBL:AAH05258.1 xref: EMBL:AAH10944.1 xref: EMBL:AAH17713.1 xref: EMBL:AAP88812.1 xref: EMBL:AAS99353.1 xref: EMBL:BAA75628.1 xref: UniProtKB:O75433 xref: UniProtKB:Q9BS73 xref: UniProtKB:Q9UJX2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004285 ! CDC23_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005801 ! cdc23-rad54b physical interaction relationship: participates_in CCO:I0005806 ! cdc23-rbpms physical interaction relationship: participates_in CCO:I0005848 ! cdc23-tsc22d4 physical interaction relationship: participates_in CCO:I0007929 ! cdc27-nek2 physical interaction relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000094 ! mitotic metaphase plate congression relationship: participates_in CCO:P0000102 ! mitotic metaphase/anaphase transition relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis relationship: participates_in CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0011060 ! CDC23_HUMAN-Phosphotyrosine267 relationship: transforms_into CCO:B0011061 ! CDC23_HUMAN-Phosphothreonine556 relationship: transforms_into CCO:B0011062 ! CDC23_HUMAN-Phosphothreonine559 relationship: transforms_into CCO:B0011063 ! CDC23_HUMAN-Phosphoserine572 relationship: transforms_into CCO:B0011064 ! CDC23_HUMAN-Phosphoserine582 relationship: transforms_into CCO:B0011065 ! CDC23_HUMAN-Phosphothreonine590 [Term] id: CCO:B0002213 name: APC7_HUMAN def: "Anaphase-promoting complex subunit 7" [UniProtKB:Q9UJX3] synonym: "APC7" EXACT [UniProtKB:Q9UJX3] synonym: "Cyclosome subunit 7" EXACT [UniProtKB:Q9UJX3] xref: EMBL:AAF05754.1 xref: EMBL:AAH02941.2 xref: EMBL:AAH09498.2 xref: EMBL:AAH17316.2 xref: EMBL:CAB70828.1 xref: UniProtKB:Q96AC4 xref: UniProtKB:Q96GF4 xref: UniProtKB:Q9BU24 xref: UniProtKB:Q9NT16 xref: UniProtKB:Q9UJX3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004080 ! ANAPC7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0002214 name: APC5_HUMAN def: "Anaphase-promoting complex subunit 5" [UniProtKB:Q9UJX4] synonym: "APC5" EXACT [UniProtKB:Q9UJX4] synonym: "Cyclosome subunit 5" EXACT [UniProtKB:Q9UJX4] xref: EMBL:AAF05753.1 xref: EMBL:AAH01081.1 xref: EMBL:AAH01950.1 xref: EMBL:AAH06301.1 xref: EMBL:AAH34243.1 xref: EMBL:CAD97812.1 xref: UniProtKB:Q8N4H7 xref: UniProtKB:Q9BQD4 xref: UniProtKB:Q9UJX4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004057 ! ANAPC5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: participates_in CCO:P0000020 ! mitotic anaphase relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041124 ! APC5_HUMAN-Phosphoserine195 relationship: transforms_into CCO:B0041125 ! APC5_HUMAN-Phosphoserine217 [Term] id: CCO:B0002215 name: APC4_HUMAN def: "Anaphase-promoting complex subunit 4" [UniProtKB:Q9UJX5] synonym: "APC4" EXACT [UniProtKB:Q9UJX5] synonym: "Cyclosome subunit 4" EXACT [UniProtKB:Q9UJX5] xref: EMBL:AAF05752.1 xref: EMBL:CAB89245.1 xref: UniProtKB:Q9NSH6 xref: UniProtKB:Q9UJX5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004056 ! ANAPC4_human relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000282 ! anaphase-promoting complex relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: participates_in CCO:P0000020 ! mitotic anaphase relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041122 ! APC4_HUMAN-Phosphotyrosine469 relationship: transforms_into CCO:B0041123 ! APC4_HUMAN-Phosphoserine779 [Term] id: CCO:B0002216 name: ANC2_HUMAN def: "Anaphase-promoting complex subunit 2" [UniProtKB:Q9UJX6] synonym: "APC2" EXACT [UniProtKB:Q9UJX6] synonym: "Cyclosome subunit 2" EXACT [UniProtKB:Q9UJX6] xref: EMBL:AAF05751.1 xref: EMBL:AAH01579.1 xref: EMBL:AAH09487.2 xref: EMBL:AAH32503.1 xref: EMBL:BAA92644.1 xref: EMBL:CAH72881.1 xref: UniProtKB:Q5VSG1 xref: UniProtKB:Q96DG5 xref: UniProtKB:Q96GG4 xref: UniProtKB:Q9P2E1 xref: UniProtKB:Q9UJX6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004055 ! ANAPC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007929 ! cdc27-nek2 physical interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000141 ! cyclin catabolic process relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0010521 ! ANC2_HUMAN-Phosphoserine218 relationship: transforms_into CCO:B0010522 ! ANC2_HUMAN-Phosphoserine314 relationship: transforms_into CCO:B0010523 ! ANC2_HUMAN-Phosphoserine534 relationship: transforms_into CCO:B0031290 ! ANC2_HUMAN-Phosphotyrosine810 [Term] id: CCO:B0002217 name: ING1_HUMAN def: "Inhibitor of growth protein 1" [UniProtKB:Q9UK53] xref: EMBL:AAB60879.1 xref: EMBL:AAC00501.1 xref: EMBL:AAF07920.1 xref: EMBL:AAF07921.1 xref: EMBL:AAF37421.1 xref: EMBL:AAF37422.1 xref: EMBL:AAF37423.1 xref: EMBL:AAG02578.1 xref: EMBL:AAG02579.1 xref: EMBL:AAG12174.1 xref: EMBL:AAG12175.1 xref: EMBL:BAA82886.1 xref: EMBL:BAA82887.1 xref: EMBL:BAA82888.1 xref: EMBL:BAA82889.1 xref: EMBL:BAA82890.1 xref: EMBL:BAA83462.1 xref: EMBL:BAA83496.1 xref: EMBL:BAB08101.1 xref: EMBL:BAB08102.1 xref: EMBL:BAB08103.1 xref: EMBL:BAB20992.2 xref: EMBL:CAC38067.1 xref: UniProtKB:O00532 xref: UniProtKB:O43658 xref: UniProtKB:Q9H007 xref: UniProtKB:Q9HD98 xref: UniProtKB:Q9HD99 xref: UniProtKB:Q9NS83 xref: UniProtKB:Q9P0U6 xref: UniProtKB:Q9UBC6 xref: UniProtKB:Q9UIJ1 xref: UniProtKB:Q9UIJ2 xref: UniProtKB:Q9UIJ3 xref: UniProtKB:Q9UIJ4 xref: UniProtKB:Q9UK52 xref: UniProtKB:Q9UK53 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004892 ! ING1_human relationship: has_function CCO:F0000272 ! molecular_function relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0007072 ! c20orf20-epc1-2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002219 name: DP13A_HUMAN def: "DCC-interacting protein 13-alpha" [UniProtKB:Q9UKG1] synonym: "Adapter protein containing PH domain, PTB domain and leucine zipper motif 1" EXACT [UniProtKB:Q9UKG1] synonym: "Dip13-alpha" EXACT [UniProtKB:Q9UKG1] xref: EMBL:AAF04012.1 xref: EMBL:AAH28599.1 xref: EMBL:AAL17835.1 xref: EMBL:BAA92666.2 xref: UniProtKB:Q9P2B9 xref: UniProtKB:Q9UKG1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004497 ! APPL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005733 ! appl1-dip13b physical interaction relationship: participates_in CCO:I0005812 ! appl1-traf2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011566 ! DP13A_HUMAN-Phosphoserine401 relationship: transforms_into CCO:B0011567 ! DP13A_HUMAN-Phosphoserine691 [Term] id: CCO:B0002220 name: TLK1_HUMAN def: "Serine/threonine-protein kinase tousled-like 1" [UniProtKB:Q9UKI8] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9UKI8] synonym: "PKU-beta" EXACT [UniProtKB:Q9UKI8] synonym: "Tousled-like kinase 1" EXACT [UniProtKB:Q9UKI8] xref: EMBL:AAF03094.1 xref: EMBL:AAF71263.1 xref: EMBL:AAH32657.1 xref: EMBL:BAA09486.2 xref: EMBL:BAA20562.1 xref: UniProtKB:Q14150 xref: UniProtKB:Q8N591 xref: UniProtKB:Q9NYH2 xref: UniProtKB:Q9UKI8 xref: UniProtKB:Q9Y4F6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005791 ! TLK1_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0005725 ! tlk1-tlk1 physical interaction relationship: participates_in CCO:I0005855 ! dkfzp564e2182-tlk1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014409 ! TLK1_HUMAN-Phosphoserine159 relationship: transforms_into CCO:B0014410 ! TLK1_HUMAN-Phosphothreonine179 relationship: transforms_into CCO:B0014411 ! TLK1_HUMAN-Phosphoserine190 relationship: transforms_into CCO:B0014412 ! TLK1_HUMAN-Phosphoserine743 [Term] id: CCO:B0002221 name: FBX5_HUMAN def: "F-box only protein 5" [UniProtKB:Q9UKT4] synonym: "Early mitotic inhibitor 1" EXACT [UniProtKB:Q9UKT4] xref: EMBL:AAF04469.1 xref: EMBL:AAH18905.1 xref: EMBL:AAL86610.1 xref: EMBL:CAI18895.1 xref: UniProtKB:Q8WV29 xref: UniProtKB:Q9UGC8 xref: UniProtKB:Q9UKT4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004626 ! FBXO5_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:I0006995 ! fbxo5-plk1 phosphorylation relationship: participates_in CCO:I0006996 ! fbxo5-plk1-1 phosphorylation relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000138 ! regulation of mitotic cell cycle relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0002222 name: HDAC9_HUMAN def: "Histone deacetylase 9" [UniProtKB:Q9UKV0] synonym: "EC 3.5.1.98" EXACT [UniProtKB:Q9UKV0] synonym: "HD7" EXACT [UniProtKB:Q9UKV0] synonym: "HD7B" EXACT [UniProtKB:Q9UKV0] synonym: "HD9" EXACT [UniProtKB:Q9UKV0] synonym: "Histone deacetylase-related protein" EXACT [UniProtKB:Q9UKV0] synonym: "MEF2-interacting transcription repressor MITR" EXACT [UniProtKB:Q9UKV0] xref: EMBL:AAC78618.2 xref: EMBL:AAF04254.1 xref: EMBL:AAI11736.1 xref: EMBL:AAK66821.1 xref: EMBL:AAK66822.1 xref: EMBL:AAO27363.1 xref: EMBL:BAA34464.2 xref: EMBL:CAD30851.1 xref: UniProtKB:O94845 xref: UniProtKB:O95028 xref: UniProtKB:Q2M2R6 xref: UniProtKB:Q86SL1 xref: UniProtKB:Q86US3 xref: UniProtKB:Q9UKV0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004793 ! HDAC9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0012172 ! HDAC9_HUMAN-Phosphoserine220 relationship: transforms_into CCO:B0012173 ! HDAC9_HUMAN-Phosphoserine240 relationship: transforms_into CCO:B0012174 ! HDAC9_HUMAN-Phosphoserine451 [Term] id: CCO:B0002224 name: MTUS1_HUMAN def: "Mitochondrial tumor suppressor 1" [UniProtKB:Q9ULD2] synonym: "Angiotensin-II type 2 receptor-interacting protein" EXACT [UniProtKB:Q9ULD2] xref: EMBL:AAG33674.1 xref: EMBL:AAH07328.1 xref: EMBL:AAH33842.1 xref: EMBL:AAI42972.1 xref: EMBL:AAL37035.1 xref: EMBL:AAQ24172.1 xref: EMBL:BAA86602.1 xref: EMBL:BAB14894.1 xref: EMBL:CAB50791.1 xref: EMBL:CAH56128.1 xref: UniProtKB:Q63HJ6 xref: UniProtKB:Q659F4 xref: UniProtKB:Q6PK49 xref: UniProtKB:Q6URW7 xref: UniProtKB:Q8N4M6 xref: UniProtKB:Q8WTT9 xref: UniProtKB:Q9H7T2 xref: UniProtKB:Q9ULD2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005137 ! MTUS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0013041 ! MTUS1_HUMAN-Phosphoserine381 relationship: transforms_into CCO:B0013042 ! MTUS1_HUMAN-Phosphoserine443 relationship: transforms_into CCO:B0013043 ! MTUS1_HUMAN-Phosphoserine620 relationship: transforms_into CCO:B0013044 ! MTUS1_HUMAN-Phosphoserine1245 relationship: transforms_into CCO:B0013045 ! MTUS1_HUMAN-Phosphoserine1255 relationship: transforms_into CCO:B0013046 ! MTUS1_HUMAN-Phosphoserine1264 relationship: transforms_into CCO:B0013047 ! MTUS1_HUMAN-Phosphoserine1266 relationship: transforms_into CCO:B0013048 ! MTUS1_HUMAN-Phosphoserine1268 [Term] id: CCO:B0002225 name: CCPG1_HUMAN def: "Cell cycle progression protein 1" [UniProtKB:Q9ULG6] synonym: "Cell cycle progression restoration protein 8" EXACT [UniProtKB:Q9ULG6] xref: EMBL:AAB69314.1 xref: EMBL:AAH15203.1 xref: EMBL:AAH29398.1 xref: EMBL:AAH34914.1 xref: EMBL:AAH39871.1 xref: EMBL:AAK14914.1 xref: EMBL:BAA86568.2 xref: EMBL:BAB14042.1 xref: EMBL:EAW77481.1 xref: UniProtKB:A0PJH3 xref: UniProtKB:O14712 xref: UniProtKB:Q05DG4 xref: UniProtKB:Q5U5S7 xref: UniProtKB:Q8IYV8 xref: UniProtKB:Q9BY53 xref: UniProtKB:Q9HA17 xref: UniProtKB:Q9ULG6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004265 ! CCPG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0011011 ! CCPG1_HUMAN-Phosphothreonine99 relationship: transforms_into CCO:B0011012 ! CCPG1_HUMAN-Phosphoserine101 relationship: transforms_into CCO:B0011013 ! CCPG1_HUMAN-Phosphoserine104 [Term] id: CCO:B0002227 name: TPX2_HUMAN def: "Targeting protein for Xklp2" [UniProtKB:Q9ULW0] synonym: "Differentially expressed in cancerous and non-cancerous lung cells 2" EXACT [UniProtKB:Q9ULW0] synonym: "DIL-2" EXACT [UniProtKB:Q9ULW0] synonym: "Hepatocellular carcinoma-associated antigen 519" EXACT [UniProtKB:Q9ULW0] synonym: "p100" EXACT [UniProtKB:Q9ULW0] synonym: "Protein fls353" EXACT [UniProtKB:Q9ULW0] synonym: "Restricted expression proliferation-associated protein 100" EXACT [UniProtKB:Q9ULW0] xref: EMBL:AAD33965.1 xref: EMBL:AAF03248.1 xref: EMBL:AAF81695.1 xref: EMBL:AAH04136.1 xref: EMBL:AAH20207.1 xref: EMBL:BAA76931.1 xref: EMBL:BAA85893.1 xref: EMBL:CAB55982.1 xref: EMBL:CAD38007.1 xref: UniProtKB:Q9H1R4 xref: UniProtKB:Q9NRA3 xref: UniProtKB:Q9UFN9 xref: UniProtKB:Q9UL00 xref: UniProtKB:Q9ULW0 xref: UniProtKB:Q9Y2M1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005819 ! TPX2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007021 ! stk6-tpx2-1 direct interaction relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014513 ! TPX2_HUMAN-Phosphothreonine51 relationship: transforms_into CCO:B0014514 ! TPX2_HUMAN-Phosphothreonine72 relationship: transforms_into CCO:B0014515 ! TPX2_HUMAN-Phosphoserine121 relationship: transforms_into CCO:B0014516 ! TPX2_HUMAN-Phosphoserine125 relationship: transforms_into CCO:B0014517 ! TPX2_HUMAN-Phosphothreonine147 relationship: transforms_into CCO:B0014518 ! TPX2_HUMAN-Phosphoserine186 relationship: transforms_into CCO:B0014519 ! TPX2_HUMAN-Phosphoserine293 relationship: transforms_into CCO:B0014520 ! TPX2_HUMAN-Phosphothreonine338 relationship: transforms_into CCO:B0014521 ! TPX2_HUMAN-Phosphoserine359 relationship: transforms_into CCO:B0014522 ! TPX2_HUMAN-Phosphothreonine369 relationship: transforms_into CCO:B0014523 ! TPX2_HUMAN-Phosphothreonine374 relationship: transforms_into CCO:B0014524 ! TPX2_HUMAN-Phosphoserine486 relationship: transforms_into CCO:B0014525 ! TPX2_HUMAN-Phosphoserine542 relationship: transforms_into CCO:B0014526 ! TPX2_HUMAN-Phosphoserine634 relationship: transforms_into CCO:B0014527 ! TPX2_HUMAN-Phosphoserine652 relationship: transforms_into CCO:B0014528 ! TPX2_HUMAN-Phosphoserine654 relationship: transforms_into CCO:B0014529 ! TPX2_HUMAN-Phosphoserine738 [Term] id: CCO:B0002228 name: ASC_HUMAN def: "Apoptosis-associated speck-like protein containing a CARD" [UniProtKB:Q9ULZ3] synonym: "Caspase recruitment domain-containing protein 5" EXACT [UniProtKB:Q9ULZ3] synonym: "hASC" EXACT [UniProtKB:Q9ULZ3] synonym: "PYD and CARD domain-containing protein" EXACT [UniProtKB:Q9ULZ3] synonym: "Target of methylation-induced silencing 1" EXACT [UniProtKB:Q9ULZ3] xref: EMBL:AAF99665.1 xref: EMBL:AAG01187.1 xref: EMBL:AAG01188.1 xref: EMBL:AAG30286.1 xref: EMBL:AAH04470.1 xref: EMBL:AAH13569.2 xref: EMBL:AAK63850.1 xref: EMBL:BAA87339.2 xref: EMBL:BAA91012.1 xref: UniProtKB:Q96D12 xref: UniProtKB:Q9BSZ5 xref: UniProtKB:Q9HBD0 xref: UniProtKB:Q9NXJ8 xref: UniProtKB:Q9ULZ3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004105 ! PYCARD_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0002016 ! caspase activator activity relationship: has_function CCO:F0004519 ! caspase activity relationship: has_function CCO:F0004944 ! Pyrin domain binding relationship: has_function CCO:F0005714 ! protein homodimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000547 ! IkappaB kinase complex relationship: participates_in CCO:I0005908 ! prkar1a-pycard physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002229 name: FZR_HUMAN def: "Fizzy-related protein homolog" [UniProtKB:Q9UM11] synonym: "CDC20-like protein 1" EXACT [UniProtKB:Q9UM11] synonym: "Cdh1/Hct1 homolog" EXACT [UniProtKB:Q9UM11] synonym: "Fzr" EXACT [UniProtKB:Q9UM11] synonym: "hCDH1" EXACT [UniProtKB:Q9UM11] xref: EMBL:AAC62835.1 xref: EMBL:AAC62836.1 xref: EMBL:AAD26623.1 xref: EMBL:AAD26624.1 xref: EMBL:AAD52030.1 xref: EMBL:AAF20266.1 xref: EMBL:AAH13413.1 xref: EMBL:AAL28117.1 xref: EMBL:AAP35779.1 xref: EMBL:BAA86556.1 xref: EMBL:BAA86954.1 xref: EMBL:BAA86955.1 xref: UniProtKB:O75869 xref: UniProtKB:Q86U66 xref: UniProtKB:Q96NW8 xref: UniProtKB:Q9UI96 xref: UniProtKB:Q9ULH8 xref: UniProtKB:Q9UM10 xref: UniProtKB:Q9UM11 xref: UniProtKB:Q9UNQ1 xref: UniProtKB:Q9Y2T8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004667 ! FZR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008476 ! fzr1-c7orf25 physical interaction relationship: participates_in CCO:I0008477 ! fzr1-dnaja1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0011911 ! FZR_HUMAN-Phosphoserine36 relationship: transforms_into CCO:B0011912 ! FZR_HUMAN-Phosphoserine151 relationship: transforms_into CCO:B0036007 ! FZR_HUMAN-Phosphotyrosine91 relationship: transforms_into CCO:B0036008 ! FZR_HUMAN-Phosphoserine92 [Term] id: CCO:B0002230 name: APC10_HUMAN def: "Anaphase-promoting complex subunit 10" [UniProtKB:Q9UM13] synonym: "APC10" EXACT [UniProtKB:Q9UM13] synonym: "Cyclosome subunit 10" EXACT [UniProtKB:Q9UM13] xref: EMBL:AAD30527.1 xref: EMBL:AAH05217.1 xref: EMBL:ABB96248.1 xref: EMBL:BAA86953.1 xref: EMBL:CAB45705.1 xref: UniProtKB:Q2V500 xref: UniProtKB:Q9UG51 xref: UniProtKB:Q9UM13 xref: UniProtKB:Q9Y5R0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004078 ! ANAPC10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle relationship: participates_in CCO:P0000020 ! mitotic anaphase relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0002231 name: PLAL1_HUMAN def: "Zinc finger protein PLAGL1" [UniProtKB:Q9UM63] synonym: "Lost on transformation 1" EXACT [UniProtKB:Q9UM63] synonym: "LOT-1" EXACT [UniProtKB:Q9UM63] synonym: "Pleiomorphic adenoma-like protein 1" EXACT [UniProtKB:Q9UM63] synonym: "Tumor supressor ZAC" EXACT [UniProtKB:Q9UM63] xref: EMBL:AAB67041.1 xref: EMBL:AAC34250.1 xref: EMBL:AAH74814.1 xref: EMBL:AAI09086.1 xref: EMBL:AAI09087.1 xref: EMBL:CAA06994.1 xref: EMBL:CAB56564.1 xref: EMBL:CAC39614.1 xref: EMBL:CAC39615.1 xref: EMBL:CAD97639.1 xref: EMBL:CAI21447.1 xref: EMBL:EAW47852.1 xref: EMBL:EAW47854.1 xref: UniProtKB:O76019 xref: UniProtKB:Q7Z3V8 xref: UniProtKB:Q92981 xref: UniProtKB:Q96JR9 xref: UniProtKB:Q9UIZ0 xref: UniProtKB:Q9UM63 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005332 ! PLAGL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002232 name: SUFU_HUMAN def: "Suppressor of fused homolog" [UniProtKB:Q9UMX1] synonym: "SUFUH" EXACT [UniProtKB:Q9UMX1] xref: EMBL:AAD50501.1 xref: EMBL:AAD51655.1 xref: EMBL:AAF23890.1 xref: EMBL:AAF23893.1 xref: EMBL:AAF35866.1 xref: EMBL:AAH13291.1 xref: EMBL:AAM08947.1 xref: EMBL:AAQ88914.1 xref: EMBL:CAB70752.1 xref: EMBL:CAI12525.1 xref: EMBL:CAI12526.1 xref: EMBL:CAI39614.1 xref: EMBL:CAI39615.1 xref: EMBL:CAI40864.1 xref: EMBL:CAI40865.1 xref: UniProtKB:Q7LCP7 xref: UniProtKB:Q9NT90 xref: UniProtKB:Q9NZ07 xref: UniProtKB:Q9UHK2 xref: UniProtKB:Q9UHM8 xref: UniProtKB:Q9UMX1 xref: UniProtKB:Q9UMY0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005702 ! SUFU_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005726 ! qprt-sufu physical interaction relationship: participates_in CCO:I0005758 ! glis3-sufu physical interaction relationship: participates_in CCO:I0005826 ! rcn3-sufu physical interaction relationship: participates_in CCO:I0005856 ! sufu-znf446 physical interaction relationship: participates_in CCO:I0005866 ! mgc13138-sufu physical interaction relationship: participates_in CCO:I0005877 ! mid1ip1-sufu physical interaction relationship: participates_in CCO:I0005907 ! sufu-znf263 physical interaction relationship: participates_in CCO:I0005936 ! pex26-sufu physical interaction relationship: participates_in CCO:I0006048 ! stk36-sufu-1 physical interaction relationship: participates_in CCO:I0006049 ! stk36-sufu-2 physical interaction relationship: participates_in CCO:I0007136 ! gli3-sufu-1 direct interaction relationship: participates_in CCO:I0007137 ! sufu-sufu-1 direct interaction relationship: participates_in CCO:I0007889 ! sufu-rcn3 physical interaction relationship: participates_in CCO:I0007890 ! pex26-sufu-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002233 name: CC14A_HUMAN def: "Dual specificity protein phosphatase CDC14A" [UniProtKB:Q9UNH5] synonym: "CDC14 cell division cycle 14 homolog A" EXACT [UniProtKB:Q9UNH5] synonym: "EC 3.1.3.16" EXACT [UniProtKB:Q9UNH5] synonym: "EC 3.1.3.48" EXACT [UniProtKB:Q9UNH5] xref: EMBL:AAB88277.1 xref: EMBL:AAC16659.1 xref: EMBL:AAC16660.1 xref: EMBL:AAD49217.1 xref: EMBL:AAH38979.1 xref: EMBL:AAT38107.1 xref: UniProtKB:O43171 xref: UniProtKB:O60727 xref: UniProtKB:O60728 xref: UniProtKB:Q8IXX0 xref: UniProtKB:Q9UNH5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004234 ! CDC14A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002234 name: ING4_HUMAN def: "Inhibitor of growth protein 4" [UniProtKB:Q9UNL4] synonym: "p29ING4" EXACT [UniProtKB:Q9UNL4] xref: EMBL:AAD48585.1 xref: EMBL:AAG43153.1 xref: EMBL:AAH07781.1 xref: EMBL:AAH13038.2 xref: EMBL:AAL79773.1 xref: UniProtKB:Q96E15 xref: UniProtKB:Q9H3J0 xref: UniProtKB:Q9UNL4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004894 ! ING4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0012414 ! ING4_HUMAN-N6-acetyllysine127 relationship: transforms_into CCO:B0012415 ! ING4_HUMAN-N6-acetyllysine129 relationship: transforms_into CCO:B0012416 ! ING4_HUMAN-N6-acetyllysine146 relationship: transforms_into CCO:B0012417 ! ING4_HUMAN-N6-acetyllysine148 [Term] id: CCO:B0002235 name: TIM_HUMAN def: "Protein timeless homolog" [UniProtKB:Q9UNS1] synonym: "hTIM" EXACT [UniProtKB:Q9UNS1] xref: EMBL:AAC80011.1 xref: EMBL:AAH39842.1 xref: EMBL:AAH50557.1 xref: EMBL:BAA36499.1 xref: UniProtKB:O94802 xref: UniProtKB:Q86VM1 xref: UniProtKB:Q8IWH3 xref: UniProtKB:Q9UNS1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005782 ! TIMELESS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000215 ! regulation of S phase relationship: transforms_into CCO:B0014376 ! TIM_HUMAN-Phosphothreonine1089 relationship: transforms_into CCO:B0014377 ! TIM_HUMAN-Phosphoserine1173 [Term] id: CCO:B0002237 name: MACF1_HUMAN def: "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5" [UniProtKB:Q9UPN3] synonym: "620 kDa actin-binding protein" EXACT [UniProtKB:Q9UPN3] synonym: "ABP620" EXACT [UniProtKB:Q9UPN3] synonym: "Actin cross-linking family protein 7" EXACT [UniProtKB:Q9UPN3] synonym: "Macrophin-1" EXACT [UniProtKB:Q9UPN3] synonym: "Trabeculin-alpha" EXACT [UniProtKB:Q9UPN3] xref: EMBL:AAF06360.1 xref: EMBL:AAL39000.1 xref: EMBL:BAA32310.3 xref: EMBL:BAA83821.1 xref: EMBL:BAA86565.1 xref: EMBL:CAH70156.1 xref: EMBL:CAH73668.1 xref: EMBL:CAI16417.1 xref: EMBL:CAI21814.1 xref: UniProtKB:O75053 xref: UniProtKB:Q5VW20 xref: UniProtKB:Q8WXY2 xref: UniProtKB:Q9H540 xref: UniProtKB:Q9UKP0 xref: UniProtKB:Q9ULG9 xref: UniProtKB:Q9UPN3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005012 ! MACF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006589 ! disc1-macf1 physical interaction relationship: participates_in CCO:I0006590 ! disc1-macf1-2 physical interaction relationship: participates_in CCO:I0006591 ! disc1-macf1-3 physical interaction relationship: participates_in CCO:I0006592 ! disc1-macf1-4 physical interaction relationship: participates_in CCO:I0006593 ! dtnbp1-macf1 physical interaction relationship: participates_in CCO:I0006594 ! exoc1-macf1 physical interaction relationship: participates_in CCO:I0006802 ! disc1-macf1-1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0012746 ! MACF1_HUMAN-Phosphoserine280 relationship: transforms_into CCO:B0012747 ! MACF1_HUMAN-Phosphoserine1860 relationship: transforms_into CCO:B0012748 ! MACF1_HUMAN-Phosphoserine2454 relationship: transforms_into CCO:B0012749 ! MACF1_HUMAN-Phosphoserine4074 relationship: transforms_into CCO:B0012750 ! MACF1_HUMAN-Phosphoserine5372 relationship: transforms_into CCO:B0012751 ! MACF1_HUMAN-Phosphoserine5375 [Term] id: CCO:B0002238 name: MARE3_HUMAN def: "Microtubule-associated protein RP/EB family member 3" [UniProtKB:Q9UPY8] synonym: "EB1 protein family member 3" EXACT [UniProtKB:Q9UPY8] synonym: "EB3" EXACT [UniProtKB:Q9UPY8] synonym: "EBF3" EXACT [UniProtKB:Q9UPY8] synonym: "End-binding protein 3" EXACT [UniProtKB:Q9UPY8] synonym: "RP3" EXACT [UniProtKB:Q9UPY8] xref: EMBL:AAH11557.1 xref: EMBL:AAK07556.1 xref: EMBL:AAK07557.1 xref: EMBL:BAA82958.1 xref: EMBL:CAA72060.1 xref: EMBL:CAG38760.1 xref: UniProtKB:O00265 xref: UniProtKB:Q6FI15 xref: UniProtKB:Q9BZP7 xref: UniProtKB:Q9BZP8 xref: UniProtKB:Q9UPY8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005026 ! MAPRE3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005822 ! lmo2-mapre3 physical interaction relationship: participates_in CCO:I0005892 ! mapre2-mapre3 physical interaction relationship: participates_in CCO:I0008492 ! rab1a-mapre3 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0012771 ! MARE3_HUMAN-Phosphothreonine161 [Term] id: CCO:B0002239 name: PA2G4_HUMAN def: "Proliferation-associated protein 2G4" [UniProtKB:Q9UQ80] synonym: "Cell cycle protein p38-2G4 homolog" EXACT [UniProtKB:Q9UQ80] synonym: "ErbB3-binding protein 1" EXACT [UniProtKB:Q9UQ80] synonym: "hG4-1" EXACT [UniProtKB:Q9UQ80] xref: EMBL:AAB91536.1 xref: EMBL:AAD00646.1 xref: EMBL:AAD05561.1 xref: EMBL:AAH01951.1 xref: EMBL:AAH07561.1 xref: EMBL:AAH69786.1 xref: UniProtKB:O43846 xref: UniProtKB:Q9UM59 xref: UniProtKB:Q9UQ80 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005252 ! PA2G4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006052 ! pa2g4-rb1-1 physical interaction relationship: participates_in CCO:I0006053 ! rb1-pa2g4-2 physical interaction relationship: participates_in CCO:I0006054 ! pa2g4-rb1-2 physical interaction relationship: participates_in CCO:I0006055 ! pa2g4-e2f1-1 physical interaction relationship: participates_in CCO:I0006345 ! pa2g4-npm-1 colocalization relationship: participates_in CCO:I0006346 ! pa2g4-npm-2 colocalization relationship: participates_in CCO:I0007143 ! erbb3-pa2g4-1 physical interaction relationship: participates_in CCO:I0007144 ! pa2g4-ar-1 physical interaction relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: participates_in CCO:I0007294 ! pa2g4-ncl-1 physical interaction relationship: participates_in CCO:I0007418 ! rb1-pa2g4-1 physical interaction relationship: participates_in CCO:I0007916 ! pa2g4-hdac2-1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0013365 ! PA2G4_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0013366 ! PA2G4_HUMAN-Phosphoserine2 relationship: transforms_into CCO:B0013367 ! PA2G4_HUMAN-Phosphothreonine366 relationship: transforms_into CCO:B0013368 ! PA2G4_HUMAN-Phosphothreonine386 [Term] id: CCO:B0002240 name: EXO1_HUMAN def: "Exonuclease 1" [UniProtKB:Q9UQ84] synonym: "EC 3.1.-.-" EXACT [UniProtKB:Q9UQ84] synonym: "Exonuclease I" EXACT [UniProtKB:Q9UQ84] synonym: "hExo1" EXACT [UniProtKB:Q9UQ84] synonym: "hExoI" EXACT [UniProtKB:Q9UQ84] xref: EMBL:AAC32259.1 xref: EMBL:AAC32424.1 xref: EMBL:AAC33874.1 xref: EMBL:AAC63043.1 xref: EMBL:AAC69879.1 xref: EMBL:AAC69880.1 xref: EMBL:AAD13754.1 xref: EMBL:AAH07491.1 xref: EMBL:AAN39382.1 xref: EMBL:CAB45733.1 xref: EMBL:CAI15658.1 xref: UniProtKB:O60545 xref: UniProtKB:O75214 xref: UniProtKB:O75466 xref: UniProtKB:Q5T396 xref: UniProtKB:Q96IJ1 xref: UniProtKB:Q9UG38 xref: UniProtKB:Q9UNW0 xref: UniProtKB:Q9UQ84 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004594 ! EXO1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007479 ! cftr-atp2a2 physical interaction relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0011807 ! EXO1_HUMAN-Phosphoserine598 relationship: transforms_into CCO:B0011808 ! EXO1_HUMAN-Phosphoserine714 [Term] id: CCO:B0002241 name: CD2L2_HUMAN def: "PITSLRE serine/threonine-protein kinase CDC2L2" [UniProtKB:Q9UQ88] synonym: "CDK11" EXACT [UniProtKB:Q9UQ88] synonym: "Cell division cycle 2-like protein kinase 2" EXACT [UniProtKB:Q9UQ88] synonym: "EC 2.7.11.22" EXACT [UniProtKB:Q9UQ88] synonym: "Galactosyltransferase-associated protein kinase p58/GTA" EXACT [UniProtKB:Q9UQ88] xref: EMBL:AAA19585.1 xref: EMBL:AAA19594.1 xref: EMBL:AAA19595.1 xref: EMBL:AAC72083.1 xref: EMBL:AAC72084.1 xref: EMBL:AAC72085.1 xref: EMBL:AAC72086.1 xref: EMBL:AAC72087.1 xref: EMBL:AAC72088.1 xref: EMBL:AAC72089.1 xref: EMBL:AAC72090.1 xref: EMBL:AAC72091.1 xref: EMBL:AAC72092.1 xref: EMBL:AAC72093.1 xref: EMBL:AAC72094.1 xref: EMBL:AAC95297.1 xref: EMBL:AAC95298.1 xref: EMBL:AAC95299.1 xref: EMBL:AAC95300.1 xref: EMBL:AAC95302.1 xref: EMBL:AAC95303.1 xref: EMBL:CAI20032.1 xref: EMBL:CAI20033.1 xref: EMBL:CAI20034.1 xref: UniProtKB:O95227 xref: UniProtKB:O95228 xref: UniProtKB:O96012 xref: UniProtKB:Q12821 xref: UniProtKB:Q12853 xref: UniProtKB:Q12854 xref: UniProtKB:Q5QPR0 xref: UniProtKB:Q5QPR1 xref: UniProtKB:Q5QPR2 xref: UniProtKB:Q9UBC4 xref: UniProtKB:Q9UBI3 xref: UniProtKB:Q9UEI1 xref: UniProtKB:Q9UEI2 xref: UniProtKB:Q9UP53 xref: UniProtKB:Q9UP54 xref: UniProtKB:Q9UP55 xref: UniProtKB:Q9UP56 xref: UniProtKB:Q9UQ86 xref: UniProtKB:Q9UQ87 xref: UniProtKB:Q9UQ88 xref: UniProtKB:Q9UQ89 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004274 ! CDC2L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006494 ! skiv2l-cdc2l2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011025 ! CD2L2_HUMAN-Phosphoserine222 relationship: transforms_into CCO:B0011026 ! CD2L2_HUMAN-Phosphoserine271 relationship: transforms_into CCO:B0011027 ! CD2L2_HUMAN-Phosphothreonine433 relationship: transforms_into CCO:B0011028 ! CD2L2_HUMAN-Phosphotyrosine434 relationship: transforms_into CCO:B0011029 ! CD2L2_HUMAN-Phosphothreonine580 relationship: transforms_into CCO:B0011030 ! CD2L2_HUMAN-Phosphothreonine736 relationship: transforms_into CCO:B0011031 ! CD2L2_HUMAN-Phosphoserine737 [Term] id: CCO:B0002242 name: AURKC_HUMAN def: "Serine/threonine-protein kinase 13" [UniProtKB:Q9UQB9] synonym: "Aurora-C" EXACT [UniProtKB:Q9UQB9] synonym: "Aurora/Ipl1-related kinase 3" EXACT [UniProtKB:Q9UQB9] synonym: "Aurora/Ipl1/Eg2 protein 2" EXACT [UniProtKB:Q9UQB9] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9UQB9] xref: EMBL:AAC25955.1 xref: EMBL:AAC77369.1 xref: EMBL:BAA76292.1 xref: UniProtKB:O60681 xref: UniProtKB:O75442 xref: UniProtKB:Q9UPK5 xref: UniProtKB:Q9UQB9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004130 ! AURKC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002243 name: SMC3_HUMAN def: "Structural maintenance of chromosomes protein 3" [UniProtKB:Q9UQE7] synonym: "Bamacan" EXACT [UniProtKB:Q9UQE7] synonym: "Basement membrane-associated chondroitin proteoglycan" EXACT [UniProtKB:Q9UQE7] synonym: "Chondroitin sulfate proteoglycan 6" EXACT [UniProtKB:Q9UQE7] synonym: "Chromosome-associated polypeptide" EXACT [UniProtKB:Q9UQE7] synonym: "hCAP" EXACT [UniProtKB:Q9UQE7] xref: EMBL:AAC14893.1 xref: EMBL:AAD32447.1 xref: EMBL:CAA06289.1 xref: EMBL:CAI16576.1 xref: UniProtKB:O60464 xref: UniProtKB:Q5T482 xref: UniProtKB:Q9UQE7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005628 ! SMC3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006578 ! cep63-cspg6 physical interaction relationship: participates_in CCO:I0007036 ! wapl-cspg6 physical interaction relationship: participates_in CCO:I0007037 ! wapl-cspg6-3 physical interaction relationship: participates_in CCO:I0007039 ! wapl-cspg6-1 physical interaction relationship: participates_in CCO:I0007040 ! wapl-cspg6-2 physical interaction relationship: participates_in CCO:I0007177 ! cspg6-rad21 physical interaction relationship: participates_in CCO:I0007711 ! wapl-cspg6-4 physical interaction relationship: participates_in CCO:I0007712 ! wapl-cspg6-5 physical interaction relationship: participates_in CCO:I0007713 ! wapl-cspg6-6 physical interaction relationship: participates_in CCO:I0007714 ! wapl-cspg6-7 physical interaction relationship: participates_in CCO:I0007715 ! wapl-cspg6-9 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000068 ! mitotic spindle organization and biogenesis relationship: participates_in CCO:P0000076 ! sister chromatid cohesion relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0014076 ! SMC3_HUMAN-Phosphoserine787 relationship: transforms_into CCO:B0014077 ! SMC3_HUMAN-Phosphoserine1013 relationship: transforms_into CCO:B0014078 ! SMC3_HUMAN-Phosphoserine1065 relationship: transforms_into CCO:B0014079 ! SMC3_HUMAN-Phosphoserine1067 relationship: transforms_into CCO:B0014080 ! SMC3_HUMAN-Phosphoserine1074 relationship: transforms_into CCO:B0014081 ! SMC3_HUMAN-Phosphoserine1083 [Term] id: CCO:B0002244 name: HDAC5_HUMAN def: "Histone deacetylase 5" [UniProtKB:Q9UQL6] synonym: "Antigen NY-CO-9" EXACT [UniProtKB:Q9UQL6] synonym: "EC 3.5.1.98" EXACT [UniProtKB:Q9UQL6] synonym: "HD5" EXACT [UniProtKB:Q9UQL6] xref: EMBL:AAC18040.1 xref: EMBL:AAD29047.1 xref: EMBL:AAH13140.1 xref: EMBL:AAH51824.1 xref: EMBL:BAA25526.2 xref: EMBL:DAA00017.1 xref: UniProtKB:O60340 xref: UniProtKB:O60528 xref: UniProtKB:Q96DY4 xref: UniProtKB:Q9UQL6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004790 ! HDAC5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006824 ! brms1-hdac5 physical interaction relationship: participates_in CCO:I0007193 ! hdac5-brms1 physical interaction relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0012166 ! HDAC5_HUMAN-Phosphoserine259 relationship: transforms_into CCO:B0012167 ! HDAC5_HUMAN-Phosphoserine498 [Term] id: CCO:B0002245 name: JAG2_HUMAN def: "Protein jagged-2 precursor" [UniProtKB:Q9Y219] synonym: "HJ2" EXACT [UniProtKB:Q9Y219] synonym: "Jagged2" EXACT [UniProtKB:Q9Y219] xref: EMBL:AAB61285.1 xref: EMBL:AAB71189.1 xref: EMBL:AAB84215.1 xref: EMBL:AAB84216.1 xref: EMBL:AAD15562.1 xref: EMBL:CAA74706.1 xref: UniProtKB:Q9UE17 xref: UniProtKB:Q9UE99 xref: UniProtKB:Q9UNK8 xref: UniProtKB:Q9Y219 xref: UniProtKB:Q9Y6P9 xref: UniProtKB:Q9Y6Q0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004907 ! JAG2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006217 ! gfi1b-jag2 physical interaction relationship: participates_in CCO:I0007614 ! atn1-jag2 physical interaction relationship: participates_in CCO:I0007615 ! atn1-jag2-1 physical interaction relationship: participates_in CCO:I0007653 ! gfi1b-jag2-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002246 name: OSGI2_HUMAN def: "Oxidative stress-induced growth inhibitor 2" [UniProtKB:Q9Y236] synonym: "hT41" EXACT [UniProtKB:Q9Y236] xref: EMBL:AAC62231.1 xref: EMBL:AAD18134.1 xref: EMBL:AAH31054.2 xref: UniProtKB:Q9Y236 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005239 ! OSGIN2_human relationship: has_function CCO:F0000272 ! molecular_function relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0002247 name: DLEC1_HUMAN def: "Deleted in lung and esophageal cancer protein 1" [UniProtKB:Q9Y238] synonym: "Deleted in lung cancer protein 1" EXACT [UniProtKB:Q9Y238] synonym: "DLC-1" EXACT [UniProtKB:Q9Y238] xref: EMBL:BAA77247.1 xref: EMBL:BAA77624.1 xref: EMBL:CAB70676.1 xref: EMBL:CAB70884.2 xref: UniProtKB:Q9NSW0 xref: UniProtKB:Q9NTG5 xref: UniProtKB:Q9Y238 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004477 ! DLEC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002248 name: LZTS1_HUMAN def: "Leucine zipper putative tumor suppressor 1" [UniProtKB:Q9Y250] synonym: "F37/esophageal cancer-related gene-coding leucine-zipper motif" EXACT [UniProtKB:Q9Y250] synonym: "Fez1" EXACT [UniProtKB:Q9Y250] xref: EMBL:AAD23833.1 xref: EMBL:AAD23834.1 xref: EMBL:AAD23835.1 xref: EMBL:AAD23836.1 xref: EMBL:AAD23837.1 xref: EMBL:AAD23838.1 xref: EMBL:AAD23839.1 xref: EMBL:AAD23840.1 xref: EMBL:AAH75006.1 xref: EMBL:AAH75007.1 xref: UniProtKB:Q9Y250 xref: UniProtKB:Q9Y5V7 xref: UniProtKB:Q9Y5V8 xref: UniProtKB:Q9Y5V9 xref: UniProtKB:Q9Y5W0 xref: UniProtKB:Q9Y5W1 xref: UniProtKB:Q9Y5W2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005000 ! LZTS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002249 name: RUVB1_HUMAN def: "RuvB-like 1" [UniProtKB:Q9Y265] synonym: "49 kDa TATA box-binding protein-interacting protein" EXACT [UniProtKB:Q9Y265] synonym: "49 kDa TBP-interacting protein" EXACT [UniProtKB:Q9Y265] synonym: "54 kDa erythrocyte cytosolic protein" EXACT [UniProtKB:Q9Y265] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9Y265] synonym: "ECP-54" EXACT [UniProtKB:Q9Y265] synonym: "NMP 238" EXACT [UniProtKB:Q9Y265] synonym: "Nuclear matrix protein 238" EXACT [UniProtKB:Q9Y265] synonym: "Pontin 52" EXACT [UniProtKB:Q9Y265] synonym: "TAP54-alpha" EXACT [UniProtKB:Q9Y265] synonym: "TIP49a" EXACT [UniProtKB:Q9Y265] synonym: "TIP60-associated protein 54-alpha" EXACT [UniProtKB:Q9Y265] xref: EMBL:AAC77819.1 xref: EMBL:AAD04427.1 xref: EMBL:AAH02993.1 xref: EMBL:AAH12886.1 xref: EMBL:AAM45570.1 xref: EMBL:AAP35706.1 xref: EMBL:ABF13334.1 xref: EMBL:BAA28169.1 xref: EMBL:BAD96283.1 xref: EMBL:BAD96295.1 xref: EMBL:CAA08986.1 xref: EMBL:CAB46271.1 xref: UniProtKB:P82276 xref: UniProtKB:Q1KMR0 xref: UniProtKB:Q53HK5 xref: UniProtKB:Q53HL7 xref: UniProtKB:Q53Y27 xref: UniProtKB:Q9BSX9 xref: UniProtKB:Q9Y265 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005548 ! RUVBL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006019 ! htatip-trrap-1 physical interaction relationship: participates_in CCO:I0006035 ! mrgbp-ruvbl1-1 physical interaction relationship: participates_in CCO:I0006036 ! tclf1-ruvbl1-2 physical interaction relationship: participates_in CCO:I0006037 ! znf-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006038 ! tclf1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0006041 ! tclf1-ruvbl1-6 physical interaction relationship: participates_in CCO:I0006042 ! tclf1-ruvbl1-7 physical interaction relationship: participates_in CCO:I0006354 ! map3k8-ruvbl1 physical interaction relationship: participates_in CCO:I0006359 ! ikbke-ruvbl1 physical interaction relationship: participates_in CCO:I0006378 ! map3k3-ruvbl1 physical interaction relationship: participates_in CCO:I0006389 ! map3k14-ruvbl1 physical interaction relationship: participates_in CCO:I0006393 ! relb-ruvbl1 physical interaction relationship: participates_in CCO:I0006399 ! aah62584-ruvbl1 physical interaction relationship: participates_in CCO:I0006405 ! map3k7ip1-ruvbl1 physical interaction relationship: participates_in CCO:I0006408 ! q9nyj8-ruvbl1 physical interaction relationship: participates_in CCO:I0006410 ! tbk1-ruvbl1 physical interaction relationship: participates_in CCO:I0006413 ! tnfrsf1a-ruvbl1 physical interaction relationship: participates_in CCO:I0006417 ! traf2-ruvbl1 physical interaction relationship: participates_in CCO:I0006510 ! ruvbl1-ruvbl2-1 physical interaction relationship: participates_in CCO:I0006982 ! tcfcl1-ruvbl1 physical interaction relationship: participates_in CCO:I0006983 ! tcfcl1-ruvbl1-1 physical interaction relationship: participates_in CCO:I0006984 ! tcfcl1-ruvbl1-2 physical interaction relationship: participates_in CCO:I0006985 ! tcfcl1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0007072 ! c20orf20-epc1-2 physical interaction relationship: participates_in CCO:I0007410 ! c20orf20-epc1-4 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: participates_in CCO:I0007771 ! ruvbl2-ruvbl1 physical interaction relationship: participates_in CCO:I0007772 ! mrgbp-ruvbl1 physical interaction relationship: participates_in CCO:I0007773 ! znf-ruvbl physical interaction relationship: participates_in CCO:I0007774 ! znhit4-ruvbl-1 physical interaction relationship: participates_in CCO:I0007775 ! actr8-ruvbl physical interaction relationship: participates_in CCO:I0007777 ! mcrs1-ruvbl physical interaction relationship: participates_in CCO:I0007778 ! fj90652-ruvbl-1 physical interaction relationship: participates_in CCO:I0007779 ! flj20309-ruvbl-2 physical interaction relationship: participates_in CCO:I0007780 ! mrgbp-ruvbl1-2 physical interaction relationship: participates_in CCO:I0007781 ! tcfl1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0007782 ! znf-ruvbl1 physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:I0008432 ! ruvbl1-kiaa1377 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0002250 name: NUDC_HUMAN def: "Nuclear migration protein nudC" [UniProtKB:Q9Y266] synonym: "Nuclear distribution protein C homolog" EXACT [UniProtKB:Q9Y266] xref: EMBL:AAD30517.1 xref: EMBL:AAD39921.1 xref: EMBL:AAD43024.1 xref: EMBL:AAH02399.1 xref: EMBL:AAH03132.1 xref: EMBL:AAH06147.1 xref: EMBL:AAH07280.1 xref: EMBL:AAH15153.1 xref: EMBL:AAH21139.1 xref: EMBL:AAP97152.1 xref: EMBL:BAA76628.1 xref: EMBL:CAB66659.1 xref: EMBL:CAI13560.1 xref: EMBL:CAI13561.1 xref: EMBL:CAI13563.1 xref: UniProtKB:Q5QP31 xref: UniProtKB:Q5QP35 xref: UniProtKB:Q9H0N2 xref: UniProtKB:Q9Y266 xref: UniProtKB:Q9Y2B6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005223 ! NUDC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006381 ! map3k3-nudc physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0013286 ! NUDC_HUMAN-Phosphoserine139 relationship: transforms_into CCO:B0013287 ! NUDC_HUMAN-Phosphothreonine145 relationship: transforms_into CCO:B0013288 ! NUDC_HUMAN-Phosphoserine274 relationship: transforms_into CCO:B0013289 ! NUDC_HUMAN-Phosphoserine285 relationship: transforms_into CCO:B0013290 ! NUDC_HUMAN-Phosphoserine326 [Term] id: CCO:B0002252 name: SUGT1_HUMAN def: "Suppressor of G2 allele of SKP1 homolog" [UniProtKB:Q9Y2Z0] synonym: "Putative 40-6-3 protein" EXACT [UniProtKB:Q9Y2Z0] synonym: "Sgt1" EXACT [UniProtKB:Q9Y2Z0] xref: EMBL:AAD30062.1 xref: EMBL:AAH00911.1 xref: EMBL:AAP88800.1 xref: EMBL:AAQ01749.1 xref: EMBL:AAQ76039.1 xref: EMBL:CAC51433.1 xref: UniProtKB:Q5JAK5 xref: UniProtKB:Q6VXY6 xref: UniProtKB:Q9Y2Z0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005703 ! SUGT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006374 ! map3k3-sugt1 physical interaction relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0014270 ! SUGT1_HUMAN-Phosphothreonine265 relationship: transforms_into CCO:B0014271 ! SUGT1_HUMAN-Phosphotyrosine317 relationship: transforms_into CCO:B0041342 ! SUGT1_HUMAN-N-acetylalanine2 [Term] id: CCO:B0002253 name: STA13_HUMAN def: "StAR-related lipid transfer protein 13" [UniProtKB:Q9Y3M8] synonym: "46H23.2" EXACT [UniProtKB:Q9Y3M8] synonym: "Deleted in liver cancer protein 2" EXACT [UniProtKB:Q9Y3M8] synonym: "Rho GTPase-activating protein" EXACT [UniProtKB:Q9Y3M8] synonym: "StARD13" EXACT [UniProtKB:Q9Y3M8] synonym: "START domain-containing protein 13" EXACT [UniProtKB:Q9Y3M8] xref: EMBL:AAH46563.1 xref: EMBL:AAL91648.1 xref: EMBL:AAL91649.1 xref: EMBL:AAL91650.1 xref: EMBL:AAQ72791.1 xref: EMBL:CAB42562.1 xref: EMBL:CAC94774.1 xref: EMBL:CAI46026.1 xref: EMBL:CAM17900.1 xref: EMBL:CAM23625.1 xref: EMBL:CAM23626.1 xref: UniProtKB:A2A309 xref: UniProtKB:A2A310 xref: UniProtKB:Q5HYH1 xref: UniProtKB:Q5TAE3 xref: UniProtKB:Q6UN61 xref: UniProtKB:Q86TP6 xref: UniProtKB:Q86WQ3 xref: UniProtKB:Q86XT1 xref: UniProtKB:Q9Y3M8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005680 ! STARD13_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0002254 name: RBGP1_HUMAN def: "Rab GTPase-activating protein 1" [UniProtKB:Q9Y3P9] synonym: "GAP and centrosome-associated protein" EXACT [UniProtKB:Q9Y3P9] synonym: "Rab6 GTPase-activating protein GAPCenA" EXACT [UniProtKB:Q9Y3P9] xref: EMBL:AAF28917.1 xref: EMBL:AAH20609.1 xref: EMBL:AAH54492.1 xref: EMBL:BAB14031.1 xref: EMBL:BAD18594.1 xref: EMBL:CAB40267.2 xref: EMBL:CAB43313.1 xref: EMBL:CAH70298.1 xref: UniProtKB:Q05CW2 xref: UniProtKB:Q6ZMY1 xref: UniProtKB:Q9HA28 xref: UniProtKB:Q9P0E2 xref: UniProtKB:Q9UG67 xref: UniProtKB:Q9Y3P9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005444 ! RABGAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0002255 name: RBM7_HUMAN def: "RNA-binding protein 7" [UniProtKB:Q9Y580] synonym: "RNA-binding motif protein 7" EXACT [UniProtKB:Q9Y580] xref: EMBL:AAD39257.1 xref: EMBL:AAH34381.1 xref: EMBL:BAA92036.1 xref: UniProtKB:Q9NUT4 xref: UniProtKB:Q9Y580 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005449 ! RBM7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005804 ! hnrpk-rbm7 physical interaction relationship: participates_in CCO:I0005840 ! rbm7-rbmx physical interaction relationship: participates_in CCO:I0005865 ! khdrbs3-rbm7 physical interaction relationship: participates_in CCO:I0005906 ! hmg20a-rbm7 physical interaction relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0013793 ! RBM7_HUMAN-Phosphoserine136 relationship: transforms_into CCO:B0013794 ! RBM7_HUMAN-Phosphoserine137 [Term] id: CCO:B0002256 name: SPO11_HUMAN def: "Meiotic recombination protein SPO11" [UniProtKB:Q9Y5K1] synonym: "Cancer/testis antigen 35" EXACT [UniProtKB:Q9Y5K1] synonym: "CT35" EXACT [UniProtKB:Q9Y5K1] xref: EMBL:AAD44812.1 xref: EMBL:AAD52562.1 xref: EMBL:AAH33591.1 xref: EMBL:AAX44047.1 xref: EMBL:CAI21521.1 xref: EMBL:CAI21522.1 xref: UniProtKB:Q5TCI1 xref: UniProtKB:Q8N4V0 xref: UniProtKB:Q9NQM7 xref: UniProtKB:Q9NQM8 xref: UniProtKB:Q9Y5K1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005664 ! SPO11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0002257 name: CD2AP_HUMAN def: "CD2-associated protein" [UniProtKB:Q9Y5K6] synonym: "Adapter protein CMS" EXACT [UniProtKB:Q9Y5K6] synonym: "Cas ligand with multiple SH3 domains" EXACT [UniProtKB:Q9Y5K6] xref: EMBL:AAD34595.1 xref: EMBL:AAF80495.1 xref: EMBL:AAH69444.1 xref: EMBL:CAB43274.1 xref: UniProtKB:Q9UG97 xref: UniProtKB:Q9Y5K6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004272 ! CD2AP_human relationship: has_function CCO:F0001486 ! structural constituent of cytoskeleton relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003582 ! SH3 domain binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000181 ! ruffle relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000421 ! cytoskeleton relationship: located_in CCO:C0000753 ! actin cytoskeleton relationship: located_in CCO:C0001356 ! filamentous actin relationship: participates_in CCO:I0006843 ! sos1-cd2ap-1 physical interaction relationship: participates_in CCO:I0006844 ! sos2-cd2ap-1 physical interaction relationship: participates_in CCO:I0007331 ! hck-cd2ap-1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0011016 ! CD2AP_HUMAN-Phosphotyrosine88 relationship: transforms_into CCO:B0011017 ! CD2AP_HUMAN-Phosphoserine510 relationship: transforms_into CCO:B0041128 ! CD2AP_HUMAN-Phosphoserine458 [Term] id: CCO:B0002258 name: P2R3B_HUMAN def: "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta" [UniProtKB:Q9Y5P8] synonym: "PP2A, subunit B, PR48 isoform" EXACT [UniProtKB:Q9Y5P8] synonym: "Protein phosphatase 2A 48 kDa regulatory subunit" EXACT [UniProtKB:Q9Y5P8] xref: EMBL:AAD38515.1 xref: EMBL:AAH63429.1 xref: EMBL:DAA00385.1 xref: UniProtKB:Q6P4G9 xref: UniProtKB:Q7RTT1 xref: UniProtKB:Q9Y5P8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005241 ! PPP2R3B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0002259 name: UBP16_HUMAN def: "Ubiquitin carboxyl-terminal hydrolase 16" [UniProtKB:Q9Y5T5] synonym: "Deubiquitinating enzyme 16" EXACT [UniProtKB:Q9Y5T5] synonym: "EC 3.1.2.15" EXACT [UniProtKB:Q9Y5T5] synonym: "Ubiquitin thioesterase 16" EXACT [UniProtKB:Q9Y5T5] synonym: "Ubiquitin-processing protease UBP-M" EXACT [UniProtKB:Q9Y5T5] synonym: "Ubiquitin-specific-processing protease 16" EXACT [UniProtKB:Q9Y5T5] xref: EMBL:AAD20949.1 xref: EMBL:AAH30777.1 xref: EMBL:CAB90432.1 xref: UniProtKB:Q8NEL3 xref: UniProtKB:Q9Y5T5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005868 ! USP16_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014567 ! UBP16_HUMAN-Phosphoserine552 [Term] id: CCO:B0002260 name: RA54B_HUMAN def: "DNA repair and recombination protein RAD54B" [UniProtKB:Q9Y620] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9Y620] synonym: "RAD54 homolog B" EXACT [UniProtKB:Q9Y620] xref: EMBL:AAD34331.1 xref: EMBL:AAH01965.1 xref: UniProtKB:Q9Y620 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005408 ! RAD54B_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000275 ! DNA helicase activity relationship: has_function CCO:F0000309 ! RNA helicase activity relationship: has_function CCO:F0000803 ! helicase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0005793 ! rad54b-znf580 physical interaction relationship: participates_in CCO:I0005801 ! cdc23-rad54b physical interaction relationship: participates_in CCO:I0005813 ! gorasp2-rad54b physical interaction relationship: participates_in CCO:I0005817 ! psma1-rad54b physical interaction relationship: participates_in CCO:I0005835 ! myo15b-rad54b physical interaction relationship: participates_in CCO:I0005852 ! dyrk2-rad54b physical interaction relationship: participates_in CCO:I0005861 ! csnk1e-rad54b physical interaction relationship: participates_in CCO:I0005875 ! rad54b-ube2i physical interaction relationship: participates_in CCO:I0005882 ! rad54b-ribc2 physical interaction relationship: participates_in CCO:I0005913 ! rad54b-rad54b physical interaction relationship: participates_in CCO:I0005923 ! lnx-rad54b physical interaction relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0002262 name: SPIN1_HUMAN def: "Spindlin-1" [UniProtKB:Q9Y657] synonym: "Ovarian cancer-related protein" EXACT [UniProtKB:Q9Y657] xref: EMBL:AAD43035.1 xref: EMBL:AAG38112.1 xref: EMBL:AAG48367.1 xref: EMBL:AAI14516.1 xref: EMBL:AAI14566.1 xref: EMBL:AAP35978.1 xref: EMBL:CAB66653.1 xref: EMBL:CAG38515.1 xref: EMBL:CAH72406.1 xref: UniProtKB:Q7KZJ8 xref: UniProtKB:Q9GZT2 xref: UniProtKB:Q9H0N7 xref: UniProtKB:Q9Y657 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005663 ! SPIN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008506 ! spin-ptn physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0014176 ! SPIN1_HUMAN-Phosphoserine38 relationship: transforms_into CCO:B0014177 ! SPIN1_HUMAN-Phosphoserine39 [Term] id: CCO:B0002263 name: EID1_HUMAN def: "EP300-interacting inhibitor of differentiation 1" [UniProtKB:Q9Y6B2] synonym: "21 kDa pRb-associated protein" EXACT [UniProtKB:Q9Y6B2] synonym: "CREBBP/EP300 inhibitory protein 1" EXACT [UniProtKB:Q9Y6B2] synonym: "E1A-like inhibitor of differentiation 1" EXACT [UniProtKB:Q9Y6B2] synonym: "EID-1" EXACT [UniProtKB:Q9Y6B2] xref: EMBL:AAD40377.1 xref: EMBL:AAG35179.1 xref: EMBL:AAI14945.1 xref: EMBL:AAI14947.1 xref: EMBL:AAK07524.1 xref: EMBL:AAK29640.1 xref: EMBL:BAC05296.1 xref: EMBL:CAB52022.1 xref: EMBL:CAB93108.1 xref: UniProtKB:Q8N7I4 xref: UniProtKB:Q9BZT9 xref: UniProtKB:Q9Y6B2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004557 ! EID1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0036000 ! EID1_HUMAN-Phosphoserine2 relationship: transforms_into CCO:B0036001 ! EID1_HUMAN-Phosphoserine8 [Term] id: CCO:B0002264 name: MD1L1_HUMAN def: "Mitotic spindle assembly checkpoint protein MAD1" [UniProtKB:Q9Y6D9] synonym: "hMAD1" EXACT [UniProtKB:Q9Y6D9] synonym: "HsMAD1" EXACT [UniProtKB:Q9Y6D9] synonym: "MAD1-like 1" EXACT [UniProtKB:Q9Y6D9] synonym: "Mitotic arrest deficient-like protein 1" EXACT [UniProtKB:Q9Y6D9] synonym: "Mitotic checkpoint MAD1 protein-homolog" EXACT [UniProtKB:Q9Y6D9] synonym: "Tax-binding protein 181" EXACT [UniProtKB:Q9Y6D9] xref: EMBL:AAC52059.1 xref: EMBL:AAD20359.1 xref: EMBL:AAD24498.1 xref: EMBL:AAH09964.1 xref: EMBL:AAP21876.1 xref: EMBL:AAS07503.1 xref: UniProtKB:Q13312 xref: UniProtKB:Q75MI0 xref: UniProtKB:Q86UM4 xref: UniProtKB:Q9UNH0 xref: UniProtKB:Q9Y6D9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005046 ! MAD1L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005743 ! mad1l1-tex11 physical interaction relationship: participates_in CCO:I0005803 ! mad1l1-nono physical interaction relationship: participates_in CCO:I0005894 ! c1orf117-mad1l1 physical interaction relationship: participates_in CCO:I0005905 ! mad1l1-trim29 physical interaction relationship: participates_in CCO:I0005912 ! amotl2-mad1l1 physical interaction relationship: participates_in CCO:I0005927 ! mad1l1-q9bvr6 physical interaction relationship: participates_in CCO:I0005953 ! mad1l1-mad1l1 physical interaction relationship: participates_in CCO:I0005960 ! mad1l1-mad2l1 physical interaction relationship: participates_in CCO:I0006649 ! mad1l1-coil physical interaction relationship: participates_in CCO:I0006751 ! mad1l1_zw10_1 colocalization relationship: participates_in CCO:P0000019 ! mitotic metaphase relationship: participates_in CCO:P0000020 ! mitotic anaphase relationship: participates_in CCO:P0000023 ! mitotic telophase relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint relationship: transforms_into CCO:B0012844 ! MD1L1_HUMAN-Phosphoserine214 relationship: transforms_into CCO:B0012845 ! MD1L1_HUMAN-Phosphoserine428 [Term] id: CCO:B0002265 name: USH1C_HUMAN def: "Harmonin" [UniProtKB:Q9Y6N9] synonym: "Antigen NY-CO-38/NY-CO-37" EXACT [UniProtKB:Q9Y6N9] synonym: "Autoimmune enteropathy-related antigen AIE-75" EXACT [UniProtKB:Q9Y6N9] synonym: "PDZ-73 protein" EXACT [UniProtKB:Q9Y6N9] synonym: "Renal carcinoma antigen NY-REN-3" EXACT [UniProtKB:Q9Y6N9] synonym: "Usher syndrome type-1C protein" EXACT [UniProtKB:Q9Y6N9] xref: EMBL:AAC18048.1 xref: EMBL:AAC18049.1 xref: EMBL:AAH16057.1 xref: EMBL:BAA81739.1 xref: EMBL:BAA81740.1 xref: UniProtKB:Q96B29 xref: UniProtKB:Q9UM04 xref: UniProtKB:Q9UM17 xref: UniProtKB:Q9UPC3 xref: UniProtKB:Q9Y6N9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005888 ! USH1C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle [Term] id: CCO:B0002266 name: SESN1_HUMAN def: "Sestrin-1" [UniProtKB:Q9Y6P5] synonym: "p53-regulated protein PA26" EXACT [UniProtKB:Q9Y6P5] xref: EMBL:AAD04810.1 xref: EMBL:AAD04811.1 xref: EMBL:AAD04812.1 xref: EMBL:BAA91961.1 xref: UniProtKB:Q9NV00 xref: UniProtKB:Q9UPD5 xref: UniProtKB:Q9Y6P5 xref: UniProtKB:Q9Y6P6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005593 ! SESN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest relationship: transforms_into CCO:B0014017 ! SESN1_HUMAN-Phosphoserine293 [Term] id: CCO:B0002267 name: MYO16_HUMAN def: "Myosin-XVI" [UniProtKB:Q9Y6X6] synonym: "Unconventional myosin-16" EXACT [UniProtKB:Q9Y6X6] xref: EMBL:BAA74888.2 xref: EMBL:BAC04608.1 xref: EMBL:BAC87143.1 xref: EMBL:CAD39107.2 xref: EMBL:CAH70519.1 xref: EMBL:CAH70520.1 xref: EMBL:CAH70521.1 xref: EMBL:CAH73221.1 xref: EMBL:CAH73222.1 xref: EMBL:CAH73223.1 xref: EMBL:CAI15548.1 xref: EMBL:CAI15821.1 xref: EMBL:CAI15822.1 xref: EMBL:CAI15823.1 xref: EMBL:CAI16366.1 xref: EMBL:CAI16367.1 xref: UniProtKB:Q5VYX4 xref: UniProtKB:Q5VYX5 xref: UniProtKB:Q5VYX6 xref: UniProtKB:Q6ZS13 xref: UniProtKB:Q8N3C2 xref: UniProtKB:Q8N948 xref: UniProtKB:Q9Y6X6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005145 ! MYO16_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006472 ! kiaa0578-kiaa0865 physical interaction relationship: participates_in CCO:P0000244 ! negative regulation of S phase of mitotic cell cycle relationship: transforms_into CCO:B0031342 ! MYO16_HUMAN-Phosphotyrosine1432 [Term] id: CCO:B0005170 name: TRAF2_HUMAN def: "TNF receptor-associated factor 2" [UniProtKB:Q12933] synonym: "Tumor necrosis factor type 2 receptor-associated protein 3" EXACT [UniProtKB:Q12933] xref: EMBL:AAA87706.1 xref: EMBL:AAH32410.1 xref: EMBL:AAH33810.1 xref: EMBL:AAH43492.1 xref: EMBL:AAH64662.1 xref: EMBL:AAT27320.1 xref: EMBL:BAB70792.1 xref: UniProtKB:Q12933 xref: UniProtKB:Q96NT2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005823 ! TRAF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005721 ! cdca3-traf2 physical interaction relationship: participates_in CCO:I0005737 ! pin1-traf2 physical interaction relationship: participates_in CCO:I0005812 ! appl1-traf2 physical interaction relationship: participates_in CCO:I0005828 ! dlg7-traf2 physical interaction relationship: participates_in CCO:I0005878 ! lzts2-traf2 physical interaction relationship: participates_in CCO:I0005898 ! cdkn1b-traf2 physical interaction relationship: participates_in CCO:I0006417 ! traf2-ruvbl1 physical interaction [Term] id: CCO:B0005171 name: RBTN2_HUMAN def: "Rhombotin-2" [UniProtKB:P25791] synonym: "Cysteine-rich protein TTG-2" EXACT [UniProtKB:P25791] synonym: "LIM domain only protein 2" EXACT [UniProtKB:P25791] synonym: "T-cell translocation protein 2" EXACT [UniProtKB:P25791] xref: EMBL:AAF98804.1 xref: EMBL:AAH34041.1 xref: EMBL:AAH35607.1 xref: EMBL:AAH42426.1 xref: EMBL:AAH73973.1 xref: EMBL:CAA43430.1 xref: UniProtKB:P25791 xref: UniProtKB:Q9HD58 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005452 ! LMO2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005722 ! lmo2-mapre2 physical interaction relationship: participates_in CCO:I0005822 ! lmo2-mapre3 physical interaction [Term] id: CCO:B0005172 name: Q96AQ3_HUMAN def: "Activating transcription factor 4" [UniProtKB:Q96AQ3] synonym: "Activating transcription factor 4 (Tax-responsive enhancer element B67), isoform CRA_a" EXACT [UniProtKB:Q96AQ3] synonym: "ATF4 protein" EXACT [UniProtKB:Q96AQ3] synonym: "Tax-responsive enhancer element B67" EXACT [UniProtKB:Q96AQ3] xref: EMBL:AAH16855.1 xref: EMBL:AAH22088.1 xref: EMBL:AAH44895.1 xref: EMBL:AAH73754.1 xref: EMBL:CAG30270.1 xref: EMBL:EAW60341.1 xref: UniProtKB:Q96AQ3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006035 ! ATF4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005723 ! atf4-gps2 physical interaction [Term] id: CCO:B0005173 name: KPCI_HUMAN def: "Protein kinase C iota type" [UniProtKB:P41743] synonym: "aPKC-lambda/iota" EXACT [UniProtKB:P41743] synonym: "Atypical protein kinase C-lambda/iota" EXACT [UniProtKB:P41743] synonym: "EC 2.7.11.13" EXACT [UniProtKB:P41743] synonym: "nPKC-iota" EXACT [UniProtKB:P41743] synonym: "PRKC-lambda/iota" EXACT [UniProtKB:P41743] xref: EMBL:AAA60171.1 xref: EMBL:AAB17011.1 xref: EMBL:AAH22016.3 xref: UniProtKB:P41743 xref: UniProtKB:Q8WW06 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004958 ! PRKCI_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005724 ! pard6a-prkci physical interaction relationship: participates_in CCO:I0005988 ! pard6a-prkci-1 physical interaction relationship: participates_in CCO:I0005990 ! pard6b-prkci-1 physical interaction relationship: participates_in CCO:I0005992 ! pard6g-prkci-1 physical interaction relationship: participates_in CCO:I0006238 ! pard6a-prkci-3 direct interaction relationship: participates_in CCO:I0006467 ! prcki-pard6-1 physical interaction relationship: participates_in CCO:I0006830 ! prkci-pard6b-1 physical interaction relationship: participates_in CCO:I0006838 ! pard6b-rac1-2 physical interaction relationship: participates_in CCO:I0006839 ! pard6b-cdc42-5 physical interaction relationship: participates_in CCO:I0007062 ! pard6b-prkci-2 physical interaction relationship: participates_in CCO:I0007203 ! pard6a-prkci-2 physical interaction relationship: participates_in CCO:I0007206 ! prkci-pard6a-1 physical interaction relationship: participates_in CCO:I0007207 ! prkci-pard6b-2 physical interaction relationship: participates_in CCO:I0007211 ! prkci-pard3-1 physical interaction relationship: participates_in CCO:I0007221 ! pard3-prkci-2 physical interaction relationship: participates_in CCO:I0007229 ! pard6b-prkci-3 physical interaction relationship: participates_in CCO:I0007520 ! pard6a-prcki-1 physical interaction relationship: participates_in CCO:I0007521 ! prcki-pard6a-1 physical interaction relationship: transforms_into CCO:B0012629 ! KPCI_HUMAN-Phosphotyrosine256 relationship: transforms_into CCO:B0012630 ! KPCI_HUMAN-Phosphotyrosine271 relationship: transforms_into CCO:B0012631 ! KPCI_HUMAN-Phosphotyrosine325 relationship: transforms_into CCO:B0012632 ! KPCI_HUMAN-Phosphothreonine403 relationship: transforms_into CCO:B0012633 ! KPCI_HUMAN-Phosphothreonine555 [Term] id: CCO:B0005174 name: NADC_HUMAN def: "Nicotinate-nucleotide pyrophosphorylase [carboxylating]" [UniProtKB:Q15274] synonym: "EC 2.4.2.19" EXACT [UniProtKB:Q15274] synonym: "QAPRTase" EXACT [UniProtKB:Q15274] synonym: "QPRTase" EXACT [UniProtKB:Q15274] synonym: "Quinolinate phosphoribosyltransferase [decarboxylating]" EXACT [UniProtKB:Q15274] xref: EMBL:AAH05060.1 xref: EMBL:AAH10033.1 xref: EMBL:AAH18910.1 xref: EMBL:AAP35895.1 xref: EMBL:BAA11242.1 xref: UniProtKB:Q15274 xref: UniProtKB:Q53XW7 xref: UniProtKB:Q96G22 xref: UniProtKB:Q9BSG6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005155 ! QPRT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005726 ! qprt-sufu physical interaction [Term] id: CCO:B0005176 name: T22D4_HUMAN def: "TSC22 domain family protein 4" [UniProtKB:Q9Y3Q8] synonym: "Tsc-22-like protein THG-1" EXACT [UniProtKB:Q9Y3Q8] synonym: "TSC22-related-inducible leucine zipper protein 2" EXACT [UniProtKB:Q9Y3Q8] xref: EMBL:AAH01486.1 xref: EMBL:AAH01966.1 xref: EMBL:AAH02972.1 xref: EMBL:AAH10406.1 xref: EMBL:CAB43491.1 xref: UniProtKB:Q9Y3Q8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005715 ! TSC22D4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005728 ! ccnk-tsc22d4 physical interaction relationship: participates_in CCO:I0005745 ! pin1-tsc22d4 physical interaction relationship: participates_in CCO:I0005786 ! cdk5r1-tsc22d4 physical interaction relationship: participates_in CCO:I0005802 ! mad2l1-tsc22d4 physical interaction relationship: participates_in CCO:I0005848 ! cdc23-tsc22d4 physical interaction relationship: participates_in CCO:I0005867 ! cks2-tsc22d4 physical interaction relationship: participates_in CCO:I0008680 ! psma1-tsc22d4 physical interaction relationship: transforms_into CCO:B0041201 ! T22D4_HUMAN-Phosphoserine62 relationship: transforms_into CCO:B0041202 ! T22D4_HUMAN-Phosphoserine165 relationship: transforms_into CCO:B0041203 ! T22D4_HUMAN-Phosphothreonine211 relationship: transforms_into CCO:B0041204 ! T22D4_HUMAN-Phosphoserine279 [Term] id: CCO:B0005177 name: DCTN2_HUMAN def: "Dynactin subunit 2" [UniProtKB:Q13561] synonym: "50 kDa dynein-associated polypeptide" EXACT [UniProtKB:Q13561] synonym: "DCTN-50" EXACT [UniProtKB:Q13561] synonym: "Dynactin complex 50 kDa subunit" EXACT [UniProtKB:Q13561] synonym: "p50 dynamitin" EXACT [UniProtKB:Q13561] xref: EMBL:AAC50423.1 xref: EMBL:AAH00718.1 xref: EMBL:AAH09468.1 xref: EMBL:AAH14083.1 xref: EMBL:AAO34395.1 xref: UniProtKB:Q13561 xref: UniProtKB:Q86YN2 xref: UniProtKB:Q9BW17 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004448 ! DCTN2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005729 ! dctn2-gadd45a physical interaction relationship: transforms_into CCO:B0011453 ! DCTN2_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0031310 ! DCTN2_HUMAN-Phosphotyrosine86 [Term] id: CCO:B0005178 name: RBPMS_HUMAN def: "RNA-binding protein with multiple splicing" [UniProtKB:Q93062] synonym: "RBP-MS" EXACT [UniProtKB:Q93062] xref: EMBL:AAH03608.1 xref: EMBL:BAA12225.1 xref: EMBL:BAA12226.1 xref: EMBL:BAA12227.1 xref: EMBL:BAA12228.1 xref: EMBL:BAA12229.1 xref: UniProtKB:Q92516 xref: UniProtKB:Q92517 xref: UniProtKB:Q92518 xref: UniProtKB:Q93062 xref: UniProtKB:Q96J26 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005451 ! RBPMS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005730 ! lzts2-rbpms physical interaction relationship: participates_in CCO:I0005798 ! ccnk-rbpms physical interaction relationship: participates_in CCO:I0005806 ! cdc23-rbpms physical interaction relationship: participates_in CCO:I0005881 ! pin1-rbpms physical interaction [Term] id: CCO:B0005179 name: CH032_HUMAN def: "Uncharacterized protein C8orf32" [UniProtKB:Q96HA8] xref: EMBL:AAH08781.1 xref: EMBL:BAA91488.1 xref: UniProtKB:Q96HA8 xref: UniProtKB:Q9NW95 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004341 ! C8orf32_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005731 ! c8orf32-nme1 physical interaction [Term] id: CCO:B0005180 name: DAZP2_HUMAN def: "DAZ-associated protein 2" [UniProtKB:Q15038] synonym: "Deleted in azoospermia-associated protein 2" EXACT [UniProtKB:Q15038] xref: EMBL:AAH02334.1 xref: EMBL:AAH07900.1 xref: EMBL:AAR11454.1 xref: EMBL:BAA06545.2 xref: UniProtKB:Q15038 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004439 ! DAZAP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005732 ! dazap2-sept2 physical interaction [Term] id: CCO:B0005181 name: UBQL1_HUMAN def: "Ubiquilin-1" [UniProtKB:Q9UMX0] synonym: "hPLIC-1" EXACT [UniProtKB:Q9UMX0] synonym: "PLIC-1" EXACT [UniProtKB:Q9UMX0] synonym: "Protein linking IAP with cytoskeleton 1" EXACT [UniProtKB:Q9UMX0] xref: EMBL:AAD49751.3 xref: EMBL:AAG02473.1 xref: EMBL:AAH10066.1 xref: EMBL:AAH39294.1 xref: EMBL:BAB20436.1 xref: EMBL:BAC11045.1 xref: EMBL:CAB66578.1 xref: UniProtKB:Q8IXS9 xref: UniProtKB:Q8N2Q3 xref: UniProtKB:Q9H0T8 xref: UniProtKB:Q9H3R4 xref: UniProtKB:Q9HAZ5 xref: UniProtKB:Q9UMX0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005872 ! UBQLN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005789 ! hrasls3-ubqln1 physical interaction [Term] id: CCO:B0005183 name: PLDN_HUMAN def: "Pallidin" [UniProtKB:Q9UL45] synonym: "Pallid protein homolog" EXACT [UniProtKB:Q9UL45] synonym: "Syntaxin 13-interacting protein" EXACT [UniProtKB:Q9UL45] xref: EMBL:AAF08343.1 xref: EMBL:AAH04819.1 xref: UniProtKB:Q9UL45 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005335 ! PLDN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005739 ! c18orf24-pldn physical interaction relationship: participates_in CCO:I0005764 ! kntc2-pldn physical interaction [Term] id: CCO:B0005185 name: MAGBI_HUMAN def: "Melanoma-associated antigen B18" [UniProtKB:Q96M61] synonym: "MAGE-B18 antigen" EXACT [UniProtKB:Q96M61] xref: EMBL:AAH29525.1 xref: EMBL:BAB71450.1 xref: UniProtKB:Q96M61 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005018 ! MAGEB18_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005741 ! mageb18-tp53 physical interaction relationship: participates_in CCO:I0006656 ! mageb18-tp53-1 physical interaction [Term] id: CCO:B0005186 name: CR025_HUMAN def: "Uncharacterized protein C18orf25" [UniProtKB:Q96B23] xref: EMBL:AAH16149.1 xref: EMBL:AAH84579.1 xref: EMBL:CAD28470.1 xref: EMBL:CAD89920.1 xref: EMBL:CAE45812.1 xref: UniProtKB:Q5XG78 xref: UniProtKB:Q6N058 xref: UniProtKB:Q86TB5 xref: UniProtKB:Q8TCQ5 xref: UniProtKB:Q96B23 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004392 ! C18orf25_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005742 ! c18orf25-ube2i physical interaction relationship: transforms_into CCO:B0011339 ! CR025_HUMAN-Phosphoserine39 relationship: transforms_into CCO:B0011340 ! CR025_HUMAN-Phosphoserine66 relationship: transforms_into CCO:B0011341 ! CR025_HUMAN-Phosphoserine69 relationship: transforms_into CCO:B0011342 ! CR025_HUMAN-Phosphoserine327 relationship: transforms_into CCO:B0011343 ! CR025_HUMAN-Phosphoserine328 relationship: transforms_into CCO:B0011344 ! CR025_HUMAN-Phosphoserine330 [Term] id: CCO:B0005187 name: TEX11_HUMAN def: "Testis-expressed sequence 11 protein" [UniProtKB:Q8IYF3] xref: EMBL:AAH36016.2 xref: EMBL:AAK31973.1 xref: EMBL:BAB71465.1 xref: EMBL:BAB71520.1 xref: EMBL:CAI39957.1 xref: EMBL:CAI39958.1 xref: EMBL:CAI40155.1 xref: EMBL:CAI41495.1 xref: EMBL:CAI41496.1 xref: UniProtKB:Q5JQQ8 xref: UniProtKB:Q8IYF3 xref: UniProtKB:Q96LZ4 xref: UniProtKB:Q96M47 xref: UniProtKB:Q9BXU6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005762 ! TEX11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005743 ! mad1l1-tex11 physical interaction relationship: participates_in CCO:I0005769 ! cdkn1a-tex11 physical interaction [Term] id: CCO:B0005189 name: Q9BVR6_HUMAN def: "TUBGCP4 protein" [UniProtKB:Q9BVR6] xref: EMBL:AAH00966.1 xref: UniProtKB:Q9BVR6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006046 ! TUBGCP4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005746 ! krt18-q9bvr6 physical interaction relationship: participates_in CCO:I0005927 ! mad1l1-q9bvr6 physical interaction [Term] id: CCO:B0005191 name: SATB1_HUMAN def: "DNA-binding protein SATB1" [UniProtKB:Q01826] synonym: "Special AT-rich sequence-binding protein 1" EXACT [UniProtKB:Q01826] xref: EMBL:AAA60304.1 xref: EMBL:AAH01744.1 xref: UniProtKB:Q01826 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005567 ! SATB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005748 ! satb1-ube2i physical interaction [Term] id: CCO:B0005192 name: RAI1_HUMAN def: "Retinoic acid-induced protein 1" [UniProtKB:Q7Z5J4] xref: EMBL:AAH21209.1 xref: EMBL:AAO31738.1 xref: EMBL:BAB47449.1 xref: EMBL:CAB63768.1 xref: EMBL:CAC20423.1 xref: EMBL:CAC20424.1 xref: EMBL:CAD39127.1 xref: EMBL:CAD39144.1 xref: UniProtKB:Q7Z5J4 xref: UniProtKB:Q8N3B4 xref: UniProtKB:Q8ND08 xref: UniProtKB:Q8WU64 xref: UniProtKB:Q96JK5 xref: UniProtKB:Q9H1C1 xref: UniProtKB:Q9H1C2 xref: UniProtKB:Q9UF69 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005422 ! RAI1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005749 ! pin1-rai1 physical interaction relationship: transforms_into CCO:B0013688 ! RAI1_HUMAN-Phosphoserine568 relationship: transforms_into CCO:B0013689 ! RAI1_HUMAN-Phosphoserine571 relationship: transforms_into CCO:B0013690 ! RAI1_HUMAN-Phosphoserine574 relationship: transforms_into CCO:B0013691 ! RAI1_HUMAN-Phosphothreonine1476 [Term] id: CCO:B0005193 name: Q8TB93_HUMAN def: "p21(CDKN1A)-activated kinase 7" [UniProtKB:Q8TB93] xref: EMBL:AAH24179.1 xref: UniProtKB:Q8TB93 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006030 ! PAK7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005750 ! lzts2-pak7 physical interaction [Term] id: CCO:B0005195 name: DACH1_HUMAN def: "Dachshund homolog 1" [UniProtKB:Q9UI36] synonym: "Dach1" EXACT [UniProtKB:Q9UI36] xref: EMBL:AAC33466.1 xref: EMBL:AAF01351.1 xref: EMBL:AAH21219.2 xref: EMBL:AAL08487.1 xref: EMBL:CAA06666.1 xref: EMBL:CAB45153.1 xref: EMBL:CAC12840.2 xref: EMBL:CAH73005.1 xref: EMBL:CAH73006.1 xref: EMBL:CAH73303.1 xref: EMBL:CAH73304.1 xref: EMBL:CAI14979.1 xref: EMBL:CAI14980.1 xref: EMBL:CAI16673.1 xref: UniProtKB:O75523 xref: UniProtKB:O75687 xref: UniProtKB:Q5VYY3 xref: UniProtKB:Q5VYY4 xref: UniProtKB:Q96SG3 xref: UniProtKB:Q96SG4 xref: UniProtKB:Q9H524 xref: UniProtKB:Q9UI36 xref: UniProtKB:Q9UMH4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004434 ! DACH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005752 ! dach1-ube2i physical interaction relationship: transforms_into CCO:B0011423 ! DACH1_HUMAN-Phosphothreonine578 relationship: transforms_into CCO:B0011424 ! DACH1_HUMAN-Phosphoserine581 relationship: transforms_into CCO:B0011425 ! DACH1_HUMAN-Phosphothreonine582 relationship: transforms_into CCO:B0011426 ! DACH1_HUMAN-Phosphothreonine584 [Term] id: CCO:B0005196 name: Q8N374_HUMAN def: "MYO15B protein" [UniProtKB:Q8N374] xref: EMBL:AAH27875.1 xref: UniProtKB:Q8N374 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006021 ! MYO15B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005753 ! myo15b-sssca1 physical interaction relationship: participates_in CCO:I0005835 ! myo15b-rad54b physical interaction [Term] id: CCO:B0005197 name: AP2B1_HUMAN def: "AP-2 complex subunit beta-1" [UniProtKB:P63010] synonym: "Adapter-related protein complex 2 beta-1 subunit" EXACT [UniProtKB:P63010] synonym: "AP105B" EXACT [UniProtKB:P63010] synonym: "Beta-adaptin" EXACT [UniProtKB:P63010] synonym: "Beta2-adaptin" EXACT [UniProtKB:P63010] synonym: "Clathrin assembly protein complex 2 beta large chain" EXACT [UniProtKB:P63010] synonym: "Plasma membrane adaptor HA2/AP2 adaptin beta subunit" EXACT [UniProtKB:P63010] xref: EMBL:AAA35583.1 xref: EMBL:AAH06201.1 xref: EMBL:EAW80133.1 xref: UniProtKB:A6NJP3 xref: UniProtKB:P21851 xref: UniProtKB:P63010 xref: UniProtKB:Q96J19 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004073 ! AP2B1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005754 ! ap2b1-mlh1 physical interaction relationship: transforms_into CCO:B0010564 ! AP2B1_HUMAN-Phosphotyrosine737 relationship: transforms_into CCO:B0031293 ! AP2B1_HUMAN-Phosphotyrosine888 [Term] id: CCO:B0005198 name: NUDC3_HUMAN def: "NudC domain-containing protein 3" [UniProtKB:Q8IVD9] xref: EMBL:AAH03691.1 xref: EMBL:AAH11673.1 xref: EMBL:AAH35014.1 xref: EMBL:AAQ96892.1 xref: EMBL:BAA83020.1 xref: EMBL:BAB14855.1 xref: UniProtKB:Q8IVD9 xref: UniProtKB:Q9BTI3 xref: UniProtKB:Q9H7W9 xref: UniProtKB:Q9UPT4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005222 ! NUDCD3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005755 ! nudcd3-ube2i physical interaction relationship: transforms_into CCO:B0013284 ! NUDC3_HUMAN-Phosphoserine146 relationship: transforms_into CCO:B0013285 ! NUDC3_HUMAN-Phosphoserine340 [Term] id: CCO:B0005199 name: HPBP1_HUMAN def: "Hsp70-binding protein 1" [UniProtKB:Q9NZL4] synonym: "Heat shock protein-binding protein 1" EXACT [UniProtKB:Q9NZL4] synonym: "Hsp70-binding protein 2" EXACT [UniProtKB:Q9NZL4] synonym: "Hsp70-interacting protein 1" EXACT [UniProtKB:Q9NZL4] synonym: "Hsp70-interacting protein 2" EXACT [UniProtKB:Q9NZL4] synonym: "HspBP1" EXACT [UniProtKB:Q9NZL4] synonym: "HspBP2" EXACT [UniProtKB:Q9NZL4] xref: EMBL:AAC79703.1 xref: EMBL:AAF35833.1 xref: EMBL:AAG17238.1 xref: EMBL:AAH01236.1 xref: EMBL:AAH02373.1 xref: EMBL:BAB18742.1 xref: EMBL:BAC85399.1 xref: EMBL:CAG33399.1 xref: UniProtKB:O95351 xref: UniProtKB:Q6ZNU5 xref: UniProtKB:Q9NZL4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004826 ! HSPBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005756 ! hspa2-hspbp1 physical interaction relationship: participates_in CCO:I0006653 ! hspbp1-hspa2 physical interaction relationship: participates_in CCO:I0006663 ! hspa2-hspbp1-1 physical interaction relationship: participates_in CCO:I0008250 ! hspbp1-rif1 physical interaction [Term] id: CCO:B0005200 name: GGA2_HUMAN def: "ADP-ribosylation factor-binding protein GGA2" [UniProtKB:Q9UJY4] synonym: "Gamma-adaptin-related protein 2" EXACT [UniProtKB:Q9UJY4] synonym: "Golgi-localized, gamma ear-containing, ARF-binding protein 2" EXACT [UniProtKB:Q9UJY4] synonym: "Vear" EXACT [UniProtKB:Q9UJY4] synonym: "VHS domain and ear domain of gamma-adaptin" EXACT [UniProtKB:Q9UJY4] xref: EMBL:AAC05813.1 xref: EMBL:AAF05708.1 xref: EMBL:AAF35394.1 xref: EMBL:AAF42806.1 xref: EMBL:AAH00284.1 xref: EMBL:AAK38634.1 xref: EMBL:BAA83032.1 xref: UniProtKB:O14564 xref: UniProtKB:Q9NYN2 xref: UniProtKB:Q9UJY4 xref: UniProtKB:Q9UPS2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004697 ! GGA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005757 ! gga2-pin1 physical interaction [Term] id: CCO:B0005201 name: GLIS3_HUMAN def: "Zinc finger protein GLIS3" [UniProtKB:Q8NEA6] synonym: "GLI-similar 3" EXACT [UniProtKB:Q8NEA6] synonym: "Zinc finger protein 515" EXACT [UniProtKB:Q8NEA6] xref: EMBL:AAH33899.2 xref: UniProtKB:Q8NEA6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004703 ! GLIS3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005758 ! glis3-sufu physical interaction [Term] id: CCO:B0005202 name: LDOC1_HUMAN def: "Protein LDOC1" [UniProtKB:O95751] synonym: "Leucine zipper protein down-regulated in cancer cells" EXACT [UniProtKB:O95751] xref: EMBL:AAH03104.1 xref: EMBL:BAA34364.1 xref: EMBL:CAC18891.1 xref: EMBL:CAG33369.1 xref: UniProtKB:O95751 xref: UniProtKB:Q6IAR6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004975 ! LDOC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005838 ! krt18-ldoc1 physical interaction [Term] id: CCO:B0005203 name: Q96BX3_HUMAN def: "CUTC protein" [UniProtKB:Q96BX3] xref: EMBL:AAH15059.1 xref: UniProtKB:Q96BX3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006037 ! CUTC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005760 ! cutc-pim2 physical interaction [Term] id: CCO:B0005204 name: TRI29_HUMAN def: "Tripartite motif-containing protein 29" [UniProtKB:Q14134] synonym: "Ataxia-telangiectasia group D-associated protein" EXACT [UniProtKB:Q14134] xref: EMBL:AAA35762.1 xref: EMBL:AAG50167.1 xref: EMBL:AAG50168.1 xref: EMBL:AAH17352.1 xref: UniProtKB:Q14134 xref: UniProtKB:Q96AA9 xref: UniProtKB:Q9BZY7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005829 ! TRIM29_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005761 ! mlh1-trim29 physical interaction relationship: participates_in CCO:I0005816 ! lzts2-trim29 physical interaction relationship: participates_in CCO:I0005901 ! trim29-ube2i physical interaction relationship: participates_in CCO:I0005905 ! mad1l1-trim29 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0014531 ! TRI29_HUMAN-Phosphoserine58 relationship: transforms_into CCO:B0014532 ! TRI29_HUMAN-Phosphoserine104 relationship: transforms_into CCO:B0014533 ! TRI29_HUMAN-Phosphoserine489 [Term] id: CCO:B0005205 name: IL1F5_HUMAN def: "Interleukin-1 family member 5" [UniProtKB:Q9UBH0] synonym: "FIL1 delta" EXACT [UniProtKB:Q9UBH0] synonym: "IL-1 delta" EXACT [UniProtKB:Q9UBH0] synonym: "IL-1-related protein 3" EXACT [UniProtKB:Q9UBH0] synonym: "IL-1F5" EXACT [UniProtKB:Q9UBH0] synonym: "IL-1HY1" EXACT [UniProtKB:Q9UBH0] synonym: "IL-1L1" EXACT [UniProtKB:Q9UBH0] synonym: "IL-1ra homolog 1" EXACT [UniProtKB:Q9UBH0] synonym: "IL-1RP3" EXACT [UniProtKB:Q9UBH0] synonym: "Interleukin-1 delta" EXACT [UniProtKB:Q9UBH0] synonym: "Interleukin-1 HY1" EXACT [UniProtKB:Q9UBH0] synonym: "Interleukin-1 receptor antagonist homolog 1" EXACT [UniProtKB:Q9UBH0] synonym: "Interleukin-1-like protein 1" EXACT [UniProtKB:Q9UBH0] xref: EMBL:AAF02757.1 xref: EMBL:AAF25210.1 xref: EMBL:AAF76981.1 xref: EMBL:AAF91274.1 xref: EMBL:AAH24747.1 xref: EMBL:AAQ89475.1 xref: EMBL:AAX59031.1 xref: EMBL:AAY14990.1 xref: EMBL:CAB59822.1 xref: EMBL:CAB59823.1 xref: EMBL:CAB67704.1 xref: EMBL:CAD29877.1 xref: UniProtKB:Q56AT9 xref: UniProtKB:Q7RTZ6 xref: UniProtKB:Q9UBH0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004880 ! IL1F5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005763 ! il1f5-mcm6 physical interaction [Term] id: CCO:B0005206 name: NDKM_HUMAN def: "Nucleoside diphosphate kinase, mitochondrial precursor" [UniProtKB:O00746] synonym: "EC 2.7.4.6" EXACT [UniProtKB:O00746] synonym: "NDK" EXACT [UniProtKB:O00746] synonym: "NDP kinase, mitochondrial" EXACT [UniProtKB:O00746] synonym: "NDPKD" EXACT [UniProtKB:O00746] synonym: "nm23-H4" EXACT [UniProtKB:O00746] synonym: "Nucleoside diphosphate kinase D" EXACT [UniProtKB:O00746] xref: EMBL:AAH04880.1 xref: EMBL:AAH17067.1 xref: EMBL:AAK61230.1 xref: EMBL:CAA68877.1 xref: EMBL:CAC37288.1 xref: UniProtKB:O00746 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005169 ! NME4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005765 ! nme1-nme4 physical interaction [Term] id: CCO:B0005207 name: K1C15_HUMAN def: "Keratin, type I cytoskeletal 15" [UniProtKB:P19012] synonym: "CK-15" EXACT [UniProtKB:P19012] synonym: "Cytokeratin-15" EXACT [UniProtKB:P19012] synonym: "K15" EXACT [UniProtKB:P19012] synonym: "Keratin-15" EXACT [UniProtKB:P19012] xref: EMBL:AAF27047.1 xref: EMBL:AAH02641.1 xref: EMBL:AAP35925.1 xref: EMBL:CAA30535.1 xref: UniProtKB:P19012 xref: UniProtKB:Q53XV8 xref: UniProtKB:Q9BUG4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004921 ! KRT15_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005766 ! krt15-krt18 physical interaction relationship: participates_in CCO:I0005937 ! krt15-mad2l1bp physical interaction relationship: participates_in CCO:I0008694 ! krt15-psma1 physical interaction relationship: participates_in CCO:I0008696 ! krt15-psmc5 physical interaction [Term] id: CCO:B0005208 name: CT195_HUMAN def: "Uncharacterized protein C20orf195" [UniProtKB:Q9BVV2] xref: EMBL:AAH00912.1 xref: EMBL:CAI95748.1 xref: UniProtKB:Q9BVV2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004413 ! C20orf195_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005767 ! mgc5356-sssca1 physical interaction [Term] id: CCO:B0005210 name: USBP1_HUMAN def: "USH1C-binding protein 1" [UniProtKB:Q8N6Y0] synonym: "AIE-75-binding protein" EXACT [UniProtKB:Q8N6Y0] synonym: "MCC-2" EXACT [UniProtKB:Q8N6Y0] synonym: "Usher syndrome type-1C protein-binding protein 1" EXACT [UniProtKB:Q8N6Y0] xref: EMBL:AAH27910.1 xref: EMBL:BAB41203.1 xref: EMBL:BAB43978.1 xref: EMBL:BAC11443.1 xref: UniProtKB:Q8N6Y0 xref: UniProtKB:Q8NBX7 xref: UniProtKB:Q96KH3 xref: UniProtKB:Q9BYI8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005887 ! USHBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005770 ! ccnk-ushbp1 physical interaction relationship: participates_in CCO:I0005899 ! kntc2-ushbp1 physical interaction relationship: participates_in CCO:I0005909 ! fancg-ushbp1 physical interaction relationship: participates_in CCO:I0006661 ! gfi1b-ushbp1 physical interaction [Term] id: CCO:B0005211 name: DVL2_HUMAN def: "Segment polarity protein dishevelled homolog DVL-2" [UniProtKB:O14641] synonym: "Dishevelled-2" EXACT [UniProtKB:O14641] synonym: "DSH homolog 2" EXACT [UniProtKB:O14641] xref: EMBL:AAB65243.1 xref: EMBL:AAH14844.1 xref: UniProtKB:O14641 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004524 ! DVL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005862 ! dvl2-tp53 physical interaction relationship: participates_in CCO:I0006655 ! dvl2-tp53-1 physical interaction [Term] id: CCO:B0005212 name: MAGAB_HUMAN def: "Melanoma-associated antigen 11" [UniProtKB:P43364] synonym: "Cancer/testis antigen 1.11" EXACT [UniProtKB:P43364] synonym: "CT1.11" EXACT [UniProtKB:P43364] synonym: "MAGE-11 antigen" EXACT [UniProtKB:P43364] xref: EMBL:AAA68870.1 xref: EMBL:AAH04479.2 xref: EMBL:AAW71787.1 xref: EMBL:BAC87161.1 xref: UniProtKB:P43364 xref: UniProtKB:Q5ETU4 xref: UniProtKB:Q6ZRZ5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005016 ! MAGEA11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005819 ! magea11-mlf1 physical interaction relationship: participates_in CCO:I0005897 ! cdkn2b-magea11 physical interaction relationship: participates_in CCO:I0005921 ! magea11-wtap physical interaction relationship: transforms_into CCO:B0012760 ! MAGAB_HUMAN-Phosphoserine76 [Term] id: CCO:B0005213 name: IKZF1_HUMAN def: "DNA-binding protein Ikaros" [UniProtKB:Q13422] synonym: "Ikaros family zinc finger protein 1" EXACT [UniProtKB:Q13422] synonym: "Lymphoid transcription factor LyF-1" EXACT [UniProtKB:Q13422] xref: EMBL:AAB50683.1 xref: EMBL:AAC50459.1 xref: EMBL:AAH18349.1 xref: UniProtKB:O00598 xref: UniProtKB:Q13422 xref: UniProtKB:Q8WVA3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004877 ! IKZF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005773 ! ube2i-znfn1a1 physical interaction [Term] id: CCO:B0005214 name: ZN581_HUMAN def: "Zinc finger protein 581" [UniProtKB:Q9P0T4] xref: EMBL:AAF36109.2 xref: EMBL:AAH01219.1 xref: EMBL:AAH10097.1 xref: EMBL:AAH71620.1 xref: EMBL:AAH71845.1 xref: UniProtKB:Q9P0T4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005965 ! ZNF581_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005774 ! lzts2-znf581 physical interaction [Term] id: CCO:B0005215 name: FBLN4_HUMAN def: "EGF-containing fibulin-like extracellular matrix protein 2 precursor" [UniProtKB:O95967] synonym: "FIBL-4" EXACT [UniProtKB:O95967] synonym: "Fibulin-4" EXACT [UniProtKB:O95967] synonym: "UPH1 protein" EXACT [UniProtKB:O95967] xref: EMBL:AAC62108.1 xref: EMBL:AAF65188.1 xref: EMBL:AAH10456.1 xref: EMBL:AAQ89258.1 xref: EMBL:CAA10791.2 xref: UniProtKB:O75967 xref: UniProtKB:O95967 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004616 ! EFEMP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005775 ! ccnk-efemp2 physical interaction relationship: participates_in CCO:I0005845 ! ccnd3-efemp2 physical interaction relationship: participates_in CCO:I0007641 ! gfi1b-efemp2 physical interaction relationship: participates_in CCO:I0007687 ! gfi1b-efemp2-1 physical interaction [Term] id: CCO:B0005216 name: RIPK2_HUMAN def: "Receptor-interacting serine/threonine-protein kinase 2" [UniProtKB:O43353] synonym: "CARD-containing IL-1 beta ICE-kinase" EXACT [UniProtKB:O43353] synonym: "CARD-containing interleukin-1 beta-converting enzyme-associated kinase" EXACT [UniProtKB:O43353] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O43353] synonym: "Receptor-interacting protein 2" EXACT [UniProtKB:O43353] synonym: "RIP-2" EXACT [UniProtKB:O43353] synonym: "RIP-like-interacting CLARP kinase" EXACT [UniProtKB:O43353] xref: EMBL:AAC24561.1 xref: EMBL:AAC25668.1 xref: EMBL:AAC27722.1 xref: EMBL:AAC34970.1 xref: EMBL:AAH04553.1 xref: EMBL:AAQ89172.1 xref: EMBL:AAQ89173.1 xref: UniProtKB:O43353 xref: UniProtKB:Q6UWF0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005493 ! RIPK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005776 ! ripk2-ube2i physical interaction relationship: participates_in CCO:I0006394 ! ripk2-hspa2 physical interaction relationship: participates_in CCO:I0008548 ! ripk2-myh10 physical interaction relationship: transforms_into CCO:B0013878 ! RIPK2_HUMAN-Phosphoserine176 relationship: transforms_into CCO:B0013879 ! RIPK2_HUMAN-Phosphoserine531 [Term] id: CCO:B0005217 name: KCNRG_HUMAN def: "Putative potassium channel regulatory protein" [UniProtKB:Q8N5I3] synonym: "Potassium channel regulator" EXACT [UniProtKB:Q8N5I3] synonym: "Protein CLLD4" EXACT [UniProtKB:Q8N5I3] xref: EMBL:AAH32343.1 xref: EMBL:AAN06090.1 xref: EMBL:AAN06091.1 xref: EMBL:AAO11777.1 xref: EMBL:AAO11778.1 xref: EMBL:AAO27464.1 xref: EMBL:AAO27465.1 xref: EMBL:CAD38633.1 xref: UniProtKB:Q8IU75 xref: UniProtKB:Q8N3Q9 xref: UniProtKB:Q8N5I3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004934 ! KCNRG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005777 ! ccnk-kcnrg physical interaction [Term] id: CCO:B0005218 name: ZMIZ2_HUMAN def: "Zinc finger MIZ domain-containing protein 2" [UniProtKB:Q8NF64] synonym: "PIAS-like protein Zimp7" EXACT [UniProtKB:Q8NF64] xref: EMBL:AAH21924.1 xref: EMBL:AAI10436.1 xref: EMBL:AAP22368.1 xref: EMBL:AAR85526.1 xref: EMBL:BAA34789.1 xref: EMBL:BAB67779.1 xref: EMBL:BAC03396.1 xref: EMBL:CAB66507.1 xref: EMBL:CAH56269.1 xref: UniProtKB:O94790 xref: UniProtKB:Q0VGB4 xref: UniProtKB:Q659A8 xref: UniProtKB:Q6JKL5 xref: UniProtKB:Q8NF64 xref: UniProtKB:Q8WTX8 xref: UniProtKB:Q96Q01 xref: UniProtKB:Q9BQH7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005957 ! ZMIZ2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005778 ! pin1-zimp7 physical interaction [Term] id: CCO:B0005219 name: FKBP6_HUMAN def: "FK506-binding protein 6" [UniProtKB:O75344] synonym: "36 kDa FK506-binding protein" EXACT [UniProtKB:O75344] synonym: "EC 5.2.1.8" EXACT [UniProtKB:O75344] synonym: "FKBP-36" EXACT [UniProtKB:O75344] synonym: "Immunophilin FKBP36" EXACT [UniProtKB:O75344] synonym: "Peptidyl-prolyl cis-trans isomerase" EXACT [UniProtKB:O75344] synonym: "PPIase" EXACT [UniProtKB:O75344] synonym: "Rotamase" EXACT [UniProtKB:O75344] xref: EMBL:AAC64249.1 xref: EMBL:AAH36817.1 xref: UniProtKB:O75344 xref: UniProtKB:Q9UDS0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004648 ! FKBP6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005781 ! ccnk-fkbp6 physical interaction [Term] id: CCO:B0005220 name: STX11_HUMAN def: "Syntaxin-11" [UniProtKB:O75558] xref: EMBL:AAC24004.1 xref: EMBL:AAC24031.1 xref: EMBL:AAD02107.1 xref: EMBL:AAH33519.1 xref: UniProtKB:O75378 xref: UniProtKB:O75558 xref: UniProtKB:O95148 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005700 ! STX11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005782 ! ccnk-stx11 physical interaction relationship: participates_in CCO:I0008803 ! stx11-psma3 physical interaction relationship: participates_in CCO:I0008811 ! stx11-psmc3 physical interaction [Term] id: CCO:B0005221 name: H31_HUMAN def: "Histone H3.1" [UniProtKB:P68431] synonym: "H3/a" EXACT [UniProtKB:P68431] synonym: "H3/b" EXACT [UniProtKB:P68431] synonym: "H3/c" EXACT [UniProtKB:P68431] synonym: "H3/d" EXACT [UniProtKB:P68431] synonym: "H3/f" EXACT [UniProtKB:P68431] synonym: "H3/h" EXACT [UniProtKB:P68431] synonym: "H3/i" EXACT [UniProtKB:P68431] synonym: "H3/j" EXACT [UniProtKB:P68431] synonym: "H3/k" EXACT [UniProtKB:P68431] synonym: "H3/l" EXACT [UniProtKB:P68431] xref: EMBL:AAA52651.1 xref: EMBL:AAA63185.1 xref: EMBL:AAH07518.1 xref: EMBL:AAH12185.1 xref: EMBL:AAH31333.1 xref: EMBL:AAH33095.1 xref: EMBL:AAH52981.1 xref: EMBL:AAH66245.1 xref: EMBL:AAH66246.1 xref: EMBL:AAH66247.1 xref: EMBL:AAH66884.1 xref: EMBL:AAH67490.1 xref: EMBL:AAH67491.1 xref: EMBL:AAH67492.1 xref: EMBL:AAH67493.1 xref: EMBL:AAH67494.1 xref: EMBL:AAH69133.1 xref: EMBL:AAH69303.1 xref: EMBL:AAH69305.2 xref: EMBL:AAH69818.1 xref: EMBL:AAH79835.1 xref: EMBL:AAH96128.1 xref: EMBL:AAH96129.1 xref: EMBL:AAH96130.1 xref: EMBL:AAH96131.1 xref: EMBL:AAH96132.1 xref: EMBL:AAH96133.1 xref: EMBL:AAH96134.1 xref: EMBL:AAH99630.1 xref: EMBL:AAI27611.1 xref: EMBL:AAN10051.1 xref: EMBL:AAN10052.1 xref: EMBL:AAN10053.1 xref: EMBL:AAN10054.1 xref: EMBL:AAN10055.1 xref: EMBL:AAN10056.1 xref: EMBL:AAN10057.1 xref: EMBL:AAN10058.1 xref: EMBL:AAN10059.1 xref: EMBL:AAN10060.1 xref: EMBL:CAA15670.1 xref: EMBL:CAA24952.1 xref: EMBL:CAA40407.1 xref: EMBL:CAA58540.1 xref: EMBL:CAA86403.1 xref: EMBL:CAB02546.1 xref: EMBL:CAB02547.1 xref: EMBL:CAB02548.1 xref: EMBL:CAB06030.1 xref: EMBL:CAB06032.1 xref: EMBL:CAB11424.1 xref: EMBL:CAC03412.1 xref: EMBL:CAC03413.1 xref: EMBL:CAC03416.1 xref: EMBL:CAC03421.1 xref: EMBL:CAD24076.1 xref: EMBL:CAG46656.1 xref: EMBL:CAG46780.1 xref: EMBL:CAG46808.1 xref: EMBL:CAG46811.1 xref: UniProtKB:A0PJT7 xref: UniProtKB:P02295 xref: UniProtKB:P02296 xref: UniProtKB:P16106 xref: UniProtKB:P68431 xref: UniProtKB:Q6ISV8 xref: UniProtKB:Q6NWP8 xref: UniProtKB:Q6NWP9 xref: UniProtKB:Q6NXU4 xref: UniProtKB:Q71DJ3 xref: UniProtKB:Q93081 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004749 ! HIST1H3A_human relationship: encoded_by CCO:G0004750 ! HIST1H3B_human relationship: encoded_by CCO:G0004751 ! HIST1H3C_human relationship: encoded_by CCO:G0004752 ! HIST1H3D_human relationship: encoded_by CCO:G0004753 ! HIST1H3E_human relationship: encoded_by CCO:G0004754 ! HIST1H3F_human relationship: encoded_by CCO:G0004755 ! HIST1H3G_human relationship: encoded_by CCO:G0004756 ! HIST1H3H_human relationship: encoded_by CCO:G0004757 ! HIST1H3I_human relationship: encoded_by CCO:G0004758 ! HIST1H3J_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005783 ! hist1h3a-nasp physical interaction relationship: participates_in CCO:I0006807 ! h3-caf1 physical interaction relationship: participates_in CCO:I0007197 ! egfr-h3fa-1 colocalization relationship: participates_in CCO:I0007726 ! h3fa-suv39h1 physical interaction relationship: transforms_into CCO:B0012023 ! H31_HUMAN-Phosphothreonine4 relationship: transforms_into CCO:B0012024 ! H31_HUMAN-N6-acetyllysine5 relationship: transforms_into CCO:B0012025 ! H31_HUMAN-N6-methyllysine5 relationship: transforms_into CCO:B0012026 ! H31_HUMAN-Citrulline9 relationship: transforms_into CCO:B0012027 ! H31_HUMAN-dimethylarginine9 relationship: transforms_into CCO:B0012028 ! H31_HUMAN-N6,N6,N6-trimethyllysine10 relationship: transforms_into CCO:B0012029 ! H31_HUMAN-N6,N6-dimethyllysine10 relationship: transforms_into CCO:B0012030 ! H31_HUMAN-N6-acetyllysine10 relationship: transforms_into CCO:B0012031 ! H31_HUMAN-N6-methyllysine10 relationship: transforms_into CCO:B0012032 ! H31_HUMAN-Phosphoserine11 relationship: transforms_into CCO:B0012033 ! H31_HUMAN-Phosphothreonine12 relationship: transforms_into CCO:B0012034 ! H31_HUMAN-N6-acetyllysine15 relationship: transforms_into CCO:B0012035 ! H31_HUMAN-dimethylarginine18 relationship: transforms_into CCO:B0012036 ! H31_HUMAN-Citrulline18 relationship: transforms_into CCO:B0012037 ! H31_HUMAN-N6-acetyllysine19 relationship: transforms_into CCO:B0012038 ! H31_HUMAN-N6-methyllysine19 relationship: transforms_into CCO:B0012039 ! H31_HUMAN-N6-acetyllysine24 relationship: transforms_into CCO:B0012040 ! H31_HUMAN-N6-methyllysine24 relationship: transforms_into CCO:B0012041 ! H31_HUMAN-N6,N6,N6-trimethyllysine28 relationship: transforms_into CCO:B0012042 ! H31_HUMAN-N6,N6-dimethyllysine28 relationship: transforms_into CCO:B0012043 ! H31_HUMAN-N6-acetyllysine28 relationship: transforms_into CCO:B0012044 ! H31_HUMAN-N6-methyllysine28 relationship: transforms_into CCO:B0012045 ! H31_HUMAN-Phosphoserine29 relationship: transforms_into CCO:B0012046 ! H31_HUMAN-N6,N6,N6-trimethyllysine37 relationship: transforms_into CCO:B0012047 ! H31_HUMAN-N6,N6-dimethyllysine37 relationship: transforms_into CCO:B0012048 ! H31_HUMAN-N6-acetyllysine37 relationship: transforms_into CCO:B0012049 ! H31_HUMAN-N6-methyllysine37 relationship: transforms_into CCO:B0012050 ! H31_HUMAN-N6-methyllysine38 relationship: transforms_into CCO:B0012051 ! H31_HUMAN-N6,N6,N6-trimethyllysine57 relationship: transforms_into CCO:B0012052 ! H31_HUMAN-N6-acetyllysine57 relationship: transforms_into CCO:B0012053 ! H31_HUMAN-N6-methyllysine57 relationship: transforms_into CCO:B0012054 ! H31_HUMAN-N6-methyllysine65 relationship: transforms_into CCO:B0012055 ! H31_HUMAN-N6,N6,N6-trimethyllysine80 relationship: transforms_into CCO:B0012056 ! H31_HUMAN-N6,N6-dimethyllysine80 relationship: transforms_into CCO:B0012057 ! H31_HUMAN-N6-acetyllysine80 relationship: transforms_into CCO:B0012058 ! H31_HUMAN-N6-methyllysine80 relationship: transforms_into CCO:B0012059 ! H31_HUMAN-N6-methyllysine123 [Term] id: CCO:B0005223 name: RBM8A_HUMAN def: "RNA-binding protein 8A" [UniProtKB:Q9Y5S9] synonym: "Binder of OVCA1-1" EXACT [UniProtKB:Q9Y5S9] synonym: "BOV-1" EXACT [UniProtKB:Q9Y5S9] synonym: "Ribonucleoprotein RBM8A" EXACT [UniProtKB:Q9Y5S9] synonym: "RNA-binding motif protein 8A" EXACT [UniProtKB:Q9Y5S9] synonym: "RNA-binding protein Y14" EXACT [UniProtKB:Q9Y5S9] xref: EMBL:AAD21089.1 xref: EMBL:AAF29078.1 xref: EMBL:AAF37551.1 xref: EMBL:AAG14951.1 xref: EMBL:AAG16781.1 xref: EMBL:AAG16782.1 xref: EMBL:AAG27091.1 xref: EMBL:AAH17088.1 xref: EMBL:AAH71577.1 xref: EMBL:AAL26999.1 xref: EMBL:CAG46604.1 xref: EMBL:CAG46622.1 xref: UniProtKB:Q6FHD1 xref: UniProtKB:Q6IQ40 xref: UniProtKB:Q9GZX8 xref: UniProtKB:Q9NZI4 xref: UniProtKB:Q9Y5S9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005450 ! RBM8A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005785 ! mcm7-rbm8a physical interaction relationship: transforms_into CCO:B0013795 ! RBM8A_HUMAN-Phosphoserine42 relationship: transforms_into CCO:B0013796 ! RBM8A_HUMAN-Phosphoserine46 relationship: transforms_into CCO:B0013797 ! RBM8A_HUMAN-Phosphoserine166 relationship: transforms_into CCO:B0013798 ! RBM8A_HUMAN-Phosphoserine168 [Term] id: CCO:B0005224 name: PDLI7_HUMAN def: "PDZ and LIM domain protein 7" [UniProtKB:Q9NR12] synonym: "LIM mineralization protein" EXACT [UniProtKB:Q9NR12] synonym: "LMP" EXACT [UniProtKB:Q9NR12] synonym: "Protein enigma" EXACT [UniProtKB:Q9NR12] xref: EMBL:AAC37565.1 xref: EMBL:AAF76152.1 xref: EMBL:AAH01093.1 xref: EMBL:AAH14521.1 xref: EMBL:AAH67806.1 xref: EMBL:AAH84575.1 xref: EMBL:AAK30567.1 xref: EMBL:AAK30568.1 xref: EMBL:AAK30569.1 xref: UniProtKB:Q14250 xref: UniProtKB:Q5XG82 xref: UniProtKB:Q6NVZ5 xref: UniProtKB:Q96C91 xref: UniProtKB:Q9BXB8 xref: UniProtKB:Q9BXB9 xref: UniProtKB:Q9NR12 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005293 ! PDLIM7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005788 ! pdlim7-ube2i physical interaction relationship: transforms_into CCO:B0013475 ! PDLI7_HUMAN-Phosphothreonine251 [Term] id: CCO:B0005225 name: EWS_HUMAN def: "RNA-binding protein EWS" [UniProtKB:Q01844] synonym: "Ewing sarcoma breakpoint region 1 protein" EXACT [UniProtKB:Q01844] synonym: "EWS oncogene" EXACT [UniProtKB:Q01844] xref: EMBL:AAH04817.1 xref: EMBL:BAA31990.1 xref: EMBL:CAA47350.1 xref: EMBL:CAA51489.1 xref: EMBL:CAA69177.1 xref: EMBL:CAA70044.1 xref: UniProtKB:Q01844 xref: UniProtKB:Q92635 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004593 ! EWSR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005932 ! ewsr1-suv39h2 physical interaction relationship: participates_in CCO:I0006651 ! ewsr1-hbp1 physical interaction relationship: participates_in CCO:I0006652 ! ewsr1-hspa2 physical interaction relationship: transforms_into CCO:B0011776 ! EWS_HUMAN-Phosphoserine266 relationship: transforms_into CCO:B0011777 ! EWS_HUMAN-Asymmetric dimethylarginine300 relationship: transforms_into CCO:B0011778 ! EWS_HUMAN-Asymmetric dimethylarginine302 relationship: transforms_into CCO:B0011779 ! EWS_HUMAN-Asymmetric dimethylarginine304 relationship: transforms_into CCO:B0011780 ! EWS_HUMAN-Asymmetric dimethylarginine309 relationship: transforms_into CCO:B0011781 ! EWS_HUMAN-Asymmetric dimethylarginine314 relationship: transforms_into CCO:B0011782 ! EWS_HUMAN-Asymmetric dimethylarginine317 relationship: transforms_into CCO:B0011783 ! EWS_HUMAN-Asymmetric dimethylarginine321 relationship: transforms_into CCO:B0011784 ! EWS_HUMAN-Asymmetric dimethylarginine455 relationship: transforms_into CCO:B0011785 ! EWS_HUMAN-Asymmetric dimethylarginine464 relationship: transforms_into CCO:B0011786 ! EWS_HUMAN-dimethylarginine471 relationship: transforms_into CCO:B0011787 ! EWS_HUMAN-Omega-N-methylarginine471 relationship: transforms_into CCO:B0011788 ! EWS_HUMAN-Asymmetric dimethylarginine490 relationship: transforms_into CCO:B0011789 ! EWS_HUMAN-Asymmetric dimethylarginine494 relationship: transforms_into CCO:B0011790 ! EWS_HUMAN-Asymmetric dimethylarginine500 relationship: transforms_into CCO:B0011791 ! EWS_HUMAN-Asymmetric dimethylarginine503 relationship: transforms_into CCO:B0011792 ! EWS_HUMAN-Asymmetric dimethylarginine506 relationship: transforms_into CCO:B0011793 ! EWS_HUMAN-Asymmetric dimethylarginine563 relationship: transforms_into CCO:B0011794 ! EWS_HUMAN-Asymmetric dimethylarginine565 relationship: transforms_into CCO:B0011795 ! EWS_HUMAN-Asymmetric dimethylarginine572 relationship: transforms_into CCO:B0011796 ! EWS_HUMAN-Asymmetric dimethylarginine575 relationship: transforms_into CCO:B0011797 ! EWS_HUMAN-Asymmetric dimethylarginine581 relationship: transforms_into CCO:B0011798 ! EWS_HUMAN-Asymmetric dimethylarginine589 relationship: transforms_into CCO:B0011799 ! EWS_HUMAN-Asymmetric dimethylarginine592 relationship: transforms_into CCO:B0011800 ! EWS_HUMAN-Asymmetric dimethylarginine596 relationship: transforms_into CCO:B0011801 ! EWS_HUMAN-Asymmetric dimethylarginine600 relationship: transforms_into CCO:B0011802 ! EWS_HUMAN-Asymmetric dimethylarginine603 relationship: transforms_into CCO:B0011803 ! EWS_HUMAN-Asymmetric dimethylarginine607 relationship: transforms_into CCO:B0011804 ! EWS_HUMAN-Asymmetric dimethylarginine615 relationship: transforms_into CCO:B0011805 ! EWS_HUMAN-Asymmetric dimethylarginine633 relationship: transforms_into CCO:B0011806 ! EWS_HUMAN-Asymmetric dimethylarginine636 [Term] id: CCO:B0005228 name: ZN580_HUMAN def: "Zinc finger protein 580" [UniProtKB:Q9UK33] synonym: "LDL-induced EC protein" EXACT [UniProtKB:Q9UK33] xref: EMBL:AAD56549.1 xref: EMBL:AAH17698.1 xref: EMBL:CAB94389.1 xref: UniProtKB:Q9NPP7 xref: UniProtKB:Q9UK33 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005964 ! ZNF580_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005793 ! rad54b-znf580 physical interaction [Term] id: CCO:B0005230 name: Q8IVD8_HUMAN def: "Zinc finger protein 646" [UniProtKB:Q8IVD8] synonym: "Zinc finger protein 646, isoform CRA_a" EXACT [UniProtKB:Q8IVD8] xref: EMBL:AAH35589.1 xref: EMBL:EAW52170.1 xref: UniProtKB:Q8IVD8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006018 ! ZNF646_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005795 ! ube2i-znf646 physical interaction [Term] id: CCO:B0005231 name: ZBED1_HUMAN def: "Zinc finger BED domain-containing protein 1" [UniProtKB:O96006] synonym: "dREF homolog" EXACT [UniProtKB:O96006] synonym: "Putative Ac-like transposable element" EXACT [UniProtKB:O96006] xref: EMBL:AAH15030.1 xref: EMBL:BAA34505.2 xref: EMBL:CAA76545.1 xref: EMBL:CAA76660.1 xref: UniProtKB:O96006 xref: UniProtKB:Q96BY4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005951 ! ZBED1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005796 ! fancg-zbed1x physical interaction relationship: participates_in CCO:I0005876 ! ube2i-zbed1x physical interaction [Term] id: CCO:B0005232 name: MDFI_HUMAN def: "MyoD family inhibitor" [UniProtKB:Q99750] synonym: "Myogenic repressor I-mf" EXACT [UniProtKB:Q99750] xref: EMBL:AAB39748.1 xref: EMBL:AAH07836.1 xref: EMBL:CAB54148.1 xref: UniProtKB:Q99750 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005051 ! MDFI_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005810 ! mdfi-pin1 physical interaction [Term] id: CCO:B0005233 name: PSA1_HUMAN def: "Proteasome subunit alpha type-1" [UniProtKB:P25786] synonym: "30 kDa prosomal protein" EXACT [UniProtKB:P25786] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P25786] synonym: "Macropain subunit C2" EXACT [UniProtKB:P25786] synonym: "Multicatalytic endopeptidase complex subunit C2" EXACT [UniProtKB:P25786] synonym: "PROS-30" EXACT [UniProtKB:P25786] synonym: "Proteasome component C2" EXACT [UniProtKB:P25786] synonym: "Proteasome nu chain" EXACT [UniProtKB:P25786] xref: EMBL:AAA92734.1 xref: EMBL:AAH02577.1 xref: EMBL:AAH05932.1 xref: EMBL:AAH08472.1 xref: EMBL:AAH09576.1 xref: EMBL:AAH15105.1 xref: EMBL:AAH15356.1 xref: EMBL:AAH22372.1 xref: EMBL:BAA00656.1 xref: EMBL:CAA43961.1 xref: UniProtKB:P25786 xref: UniProtKB:Q9BRV9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005385 ! PSMA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005799 ! ccnh-psma1 physical interaction relationship: participates_in CCO:I0005817 ! psma1-rad54b physical interaction relationship: participates_in CCO:I0005827 ! mcm6-psma1 physical interaction relationship: participates_in CCO:I0008219 ! dleu1-psma1 physical interaction relationship: participates_in CCO:I0008678 ! ndp52-psma1 physical interaction relationship: participates_in CCO:I0008680 ! psma1-tsc22d4 physical interaction relationship: participates_in CCO:I0008681 ! nmi-psma1 physical interaction relationship: participates_in CCO:I0008686 ! psma1-vim physical interaction relationship: participates_in CCO:I0008692 ! kctd17-psma1 physical interaction relationship: participates_in CCO:I0008694 ! krt15-psma1 physical interaction relationship: participates_in CCO:I0008711 ! traf6-psma1 physical interaction relationship: participates_in CCO:I0008724 ! alpha1-alpha2 physical interaction relationship: participates_in CCO:I0008725 ! alpha1-alpha7 physical interaction relationship: participates_in CCO:I0008726 ! alpha1-beta2 physical interaction relationship: participates_in CCO:I0008727 ! alpha1-beta2i physical interaction relationship: participates_in CCO:I0008728 ! alpha2-alpha1 physical interaction relationship: participates_in CCO:I0008737 ! alpha7-alpha1 physical interaction relationship: participates_in CCO:I0008761 ! psma1-coil physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0013618 ! PSA1_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0005234 name: NONO_HUMAN def: "Non-POU domain-containing octamer-binding protein" [UniProtKB:Q15233] synonym: "54 kDa nuclear RNA- and DNA-binding protein" EXACT [UniProtKB:Q15233] synonym: "55 kDa nuclear protein" EXACT [UniProtKB:Q15233] synonym: "DNA-binding p52/p100 complex, 52 kDa subunit" EXACT [UniProtKB:Q15233] synonym: "NMT55" EXACT [UniProtKB:Q15233] synonym: "NonO protein" EXACT [UniProtKB:Q15233] synonym: "p54(nrb)" EXACT [UniProtKB:Q15233] synonym: "p54nrb" EXACT [UniProtKB:Q15233] xref: EMBL:AAA03427.1 xref: EMBL:AAC37578.1 xref: EMBL:AAC51852.1 xref: EMBL:AAH02364.1 xref: EMBL:AAH03129.1 xref: EMBL:AAH12141.1 xref: EMBL:AAH28299.1 xref: EMBL:AAH69616.1 xref: EMBL:AAH69639.1 xref: EMBL:CAA72157.1 xref: EMBL:CAG33042.1 xref: UniProtKB:O00201 xref: UniProtKB:P30807 xref: UniProtKB:Q12786 xref: UniProtKB:Q15233 xref: UniProtKB:Q9BQC5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005207 ! NONO_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005803 ! mad1l1-nono physical interaction relationship: participates_in CCO:I0005915 ! nono-pin1 physical interaction relationship: transforms_into CCO:B0013236 ! NONO_HUMAN-Phosphothreonine428 relationship: transforms_into CCO:B0013237 ! NONO_HUMAN-Phosphothreonine450 [Term] id: CCO:B0005235 name: HNRPK_HUMAN def: "Heterogeneous nuclear ribonucleoprotein K" [UniProtKB:P61978] synonym: "hnRNP K" EXACT [UniProtKB:P61978] synonym: "Transformation up-regulated nuclear protein" EXACT [UniProtKB:P61978] synonym: "TUNP" EXACT [UniProtKB:P61978] xref: EMBL:AAB20770.1 xref: EMBL:AAH00355.1 xref: EMBL:AAH14980.1 xref: EMBL:BAD92799.1 xref: EMBL:CAA51267.1 xref: UniProtKB:P61978 xref: UniProtKB:Q07244 xref: UniProtKB:Q15671 xref: UniProtKB:Q59F98 xref: UniProtKB:Q60577 xref: UniProtKB:Q922Y7 xref: UniProtKB:Q96J62 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004821 ! HNRPK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005804 ! hnrpk-rbm7 physical interaction relationship: participates_in CCO:I0005929 ! hnrpk-ube2i physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007650 ! gfi1b-hnrpk physical interaction relationship: transforms_into CCO:B0012244 ! HNRPK_HUMAN-Phosphothreonine3 relationship: transforms_into CCO:B0012245 ! HNRPK_HUMAN-Phosphoserine36 relationship: transforms_into CCO:B0012246 ! HNRPK_HUMAN-Phosphoserine116 relationship: transforms_into CCO:B0012247 ! HNRPK_HUMAN-Phosphoserine214 relationship: transforms_into CCO:B0012248 ! HNRPK_HUMAN-Phosphoserine216 relationship: transforms_into CCO:B0012249 ! HNRPK_HUMAN-Phosphoserine284 relationship: transforms_into CCO:B0012250 ! HNRPK_HUMAN-Omega-N-methylated arginine296 relationship: transforms_into CCO:B0012251 ! HNRPK_HUMAN-Omega-N-methylated arginine299 relationship: transforms_into CCO:B0012252 ! HNRPK_HUMAN-Phosphoserine379 relationship: transforms_into CCO:B0041307 ! HNRPK_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0005236 name: Q8TAX5_HUMAN def: "AFF4 protein" [UniProtKB:Q8TAX5] xref: EMBL:AAH25700.1 xref: UniProtKB:Q8TAX5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006029 ! AFF4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005805 ! aff4-siah1 physical interaction [Term] id: CCO:B0005237 name: RB22A_HUMAN def: "Ras-related protein Rab-22A" [UniProtKB:Q9UL26] synonym: "Rab-22" EXACT [UniProtKB:Q9UL26] xref: EMBL:AAF00047.2 xref: EMBL:AAH15710.1 xref: EMBL:AAH63457.1 xref: EMBL:AAL75941.1 xref: EMBL:AAP35695.1 xref: EMBL:CAC10538.1 xref: EMBL:CAC15020.1 xref: UniProtKB:Q8TF12 xref: UniProtKB:Q9H4E6 xref: UniProtKB:Q9UL26 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005436 ! RAB22A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005807 ! dip13b-rab22a physical interaction [Term] id: CCO:B0005238 name: Q8N574_HUMAN def: "IKAROS family zinc finger 3" [UniProtKB:Q8N574] synonym: "Aiolos" EXACT [UniProtKB:Q8N574] synonym: "Zinc finger protein, subfamily 1A, 3 (Aiolos), isoform CRA_c" EXACT [UniProtKB:Q8N574] xref: EMBL:AAH32707.1 xref: EMBL:EAW60606.1 xref: UniProtKB:Q8N574 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006024 ! IKZF3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005808 ! ube2i-znfn1a3 physical interaction [Term] id: CCO:B0005239 name: HNRPC_HUMAN def: "Heterogeneous nuclear ribonucleoproteins C1/C2" [UniProtKB:P07910] synonym: "hnRNP C1 / hnRNP C2" EXACT [UniProtKB:P07910] xref: EMBL:AAA36576.1 xref: EMBL:AAA52680.1 xref: EMBL:AAH03394.1 xref: EMBL:AAH07052.1 xref: EMBL:AAH08364.1 xref: EMBL:AAH08423.1 xref: EMBL:AAH66932.1 xref: EMBL:AAH89438.1 xref: EMBL:AAI03759.1 xref: EMBL:AAI08659.1 xref: EMBL:BAD92764.1 xref: EMBL:BAD97237.1 xref: EMBL:CAD61934.1 xref: EMBL:CAD62300.1 xref: EMBL:CAD62326.1 xref: UniProtKB:P07910 xref: UniProtKB:P22628 xref: UniProtKB:Q53EX2 xref: UniProtKB:Q59FD3 xref: UniProtKB:Q5FWE8 xref: UniProtKB:Q86SF8 xref: UniProtKB:Q86U45 xref: UniProtKB:Q96HK7 xref: UniProtKB:Q96HM4 xref: UniProtKB:Q96IY5 xref: UniProtKB:Q9BTS3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006360 ! HNRNPC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005874 ! hnrpc-pin1 physical interaction relationship: participates_in CCO:I0005920 ! hnrpc-ube2i physical interaction relationship: transforms_into CCO:B0012212 ! HNRPC_HUMAN-Phosphoserine138 relationship: transforms_into CCO:B0012213 ! HNRPC_HUMAN-Phosphoserine162 relationship: transforms_into CCO:B0012214 ! HNRPC_HUMAN-Phosphoserine233 relationship: transforms_into CCO:B0012215 ! HNRPC_HUMAN-Phosphoserine238 relationship: transforms_into CCO:B0012216 ! HNRPC_HUMAN-Phosphoserine239 relationship: transforms_into CCO:B0012217 ! HNRPC_HUMAN-Phosphoserine240 relationship: transforms_into CCO:B0012218 ! HNRPC_HUMAN-Phosphoserine241 relationship: transforms_into CCO:B0012219 ! HNRPC_HUMAN-Phosphoserine253 relationship: transforms_into CCO:B0012220 ! HNRPC_HUMAN-Phosphoserine260 relationship: transforms_into CCO:B0012221 ! HNRPC_HUMAN-Phosphoserine299 relationship: transforms_into CCO:B0041144 ! HNRPC_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005240 name: RIBC2_HUMAN def: "RIB43A-like with coiled-coils protein 2" [UniProtKB:Q9H4K1] xref: EMBL:AAH03024.1 xref: EMBL:AAH09904.1 xref: EMBL:CAB43258.1 xref: EMBL:CAC09526.1 xref: EMBL:CAG30324.1 xref: EMBL:CAG33679.1 xref: EMBL:CAI18929.1 xref: UniProtKB:Q6ICD0 xref: UniProtKB:Q9H4K1 xref: UniProtKB:Q9Y413 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005488 ! RIBC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005811 ! atrip-ribc2 physical interaction relationship: participates_in CCO:I0005882 ! rad54b-ribc2 physical interaction [Term] id: CCO:B0005241 name: GORS2_HUMAN def: "Golgi reassembly-stacking protein 2" [UniProtKB:Q9H8Y8] synonym: "Golgi phosphoprotein 6" EXACT [UniProtKB:Q9H8Y8] synonym: "Golgi reassembly-stacking protein of 55 kDa" EXACT [UniProtKB:Q9H8Y8] synonym: "GOLPH6" EXACT [UniProtKB:Q9H8Y8] synonym: "GRASP55" EXACT [UniProtKB:Q9H8Y8] synonym: "GRS2" EXACT [UniProtKB:Q9H8Y8] synonym: "p59" EXACT [UniProtKB:Q9H8Y8] xref: EMBL:AAH07770.1 xref: EMBL:BAB14395.1 xref: EMBL:BAB14459.1 xref: EMBL:BAB55054.1 xref: EMBL:CAB55919.1 xref: UniProtKB:Q96I74 xref: UniProtKB:Q96K84 xref: UniProtKB:Q9H8Y8 xref: UniProtKB:Q9H946 xref: UniProtKB:Q9UFW4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004717 ! GORASP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005813 ! gorasp2-rad54b physical interaction relationship: participates_in CCO:I0005832 ! gorasp2-nme1 physical interaction relationship: transforms_into CCO:B0011957 ! GORS2_HUMAN-Omega-N-methylated arginine30 relationship: transforms_into CCO:B0011958 ! GORS2_HUMAN-Omega-N-methylated arginine47 relationship: transforms_into CCO:B0011959 ! GORS2_HUMAN-Phosphoserine214 relationship: transforms_into CCO:B0011960 ! GORS2_HUMAN-Phosphothreonine222 relationship: transforms_into CCO:B0011961 ! GORS2_HUMAN-Phosphothreonine225 relationship: transforms_into CCO:B0011962 ! GORS2_HUMAN-Phosphoserine409 relationship: transforms_into CCO:B0011963 ! GORS2_HUMAN-Phosphothreonine415 relationship: transforms_into CCO:B0011964 ! GORS2_HUMAN-Phosphoserine451 [Term] id: CCO:B0005242 name: Q8IUU6_HUMAN def: "IL16 protein" [UniProtKB:Q8IUU6] xref: EMBL:AAH40272.1 xref: UniProtKB:Q8IUU6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006017 ! IL16_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005815 ! il16-sssca1 physical interaction [Term] id: CCO:B0005243 name: ARD1A_HUMAN def: "N-terminal acetyltransferase complex ARD1 subunit homolog A" [UniProtKB:P41227] synonym: "EC 2.3.1.-" EXACT [UniProtKB:P41227] synonym: "EC 2.3.1.88" EXACT [UniProtKB:P41227] xref: EMBL:AAH00308.1 xref: EMBL:AAH19312.1 xref: EMBL:CAA54691.1 xref: UniProtKB:P41227 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004088 ! ARD1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005818 ! ard1-cdc25a physical interaction relationship: transforms_into CCO:B0010587 ! ARD1A_HUMAN-Phosphoserine182 relationship: transforms_into CCO:B0010588 ! ARD1A_HUMAN-Phosphoserine186 [Term] id: CCO:B0005244 name: CEP76_HUMAN def: "Centrosomal protein of 76 kDa" [UniProtKB:Q8TAP6] synonym: "Cep76" EXACT [UniProtKB:Q8TAP6] xref: EMBL:AAH26307.1 xref: EMBL:BAB14123.1 xref: EMBL:CAH56252.1 xref: UniProtKB:Q658N5 xref: UniProtKB:Q8TAP6 xref: UniProtKB:Q9H9U7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004331 ! CEP76_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005820 ! ccnk-cep76 physical interaction [Term] id: CCO:B0005245 name: Q96HA1_HUMAN def: "POM121 membrane glycoprotein" [UniProtKB:Q96HA1] synonym: "Rat" EXACT [UniProtKB:Q96HA1] synonym: "Uncharacterized protein RASSF2" EXACT [UniProtKB:Q96HA1] xref: EMBL:AAH08794.1 xref: UniProtKB:A6NFS9 xref: UniProtKB:Q96HA1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006038 ! POM121_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005821 ! c10orf3-pom121 physical interaction [Term] id: CCO:B0005246 name: RPAC1_HUMAN def: "DNA-directed RNA polymerases I and III subunit RPAC1" [UniProtKB:O15160] synonym: "AC40" EXACT [UniProtKB:O15160] synonym: "DNA-directed RNA polymerase I subunit C" EXACT [UniProtKB:O15160] synonym: "DNA-directed RNA polymerases I and III 40 kDa polypeptide" EXACT [UniProtKB:O15160] synonym: "RNA polymerases I and III subunit AC1" EXACT [UniProtKB:O15160] synonym: "RPA39" EXACT [UniProtKB:O15160] synonym: "RPA40" EXACT [UniProtKB:O15160] synonym: "RPC40" EXACT [UniProtKB:O15160] xref: EMBL:AAC14354.1 xref: EMBL:AAC39892.1 xref: EMBL:AAH08863.1 xref: EMBL:CAI42629.1 xref: UniProtKB:O15160 xref: UniProtKB:O75395 xref: UniProtKB:Q5JTE3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005525 ! POLR1C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005823 ! nme1-polr1c physical interaction relationship: transforms_into CCO:B0013930 ! RPAC1_HUMAN-Phosphotyrosine33 [Term] id: CCO:B0005248 name: RCN3_HUMAN def: "Reticulocalbin-3 precursor" [UniProtKB:Q96D15] synonym: "EF-hand calcium-binding protein RLP49" EXACT [UniProtKB:Q96D15] xref: EMBL:AAG09692.1 xref: EMBL:AAH13436.1 xref: EMBL:AAO43054.1 xref: EMBL:AAQ88789.1 xref: UniProtKB:Q96D15 xref: UniProtKB:Q9HBZ8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005458 ! RCN3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005826 ! rcn3-sufu physical interaction relationship: participates_in CCO:I0007889 ! sufu-rcn3 physical interaction [Term] id: CCO:B0005249 name: TRI37_HUMAN def: "Tripartite motif-containing protein 37" [UniProtKB:O94972] synonym: "Mulibrey nanism protein" EXACT [UniProtKB:O94972] xref: EMBL:AAH36012.1 xref: EMBL:AAL36460.1 xref: EMBL:BAA74921.1 xref: EMBL:CAD97922.1 xref: UniProtKB:O94972 xref: UniProtKB:Q7Z3E6 xref: UniProtKB:Q8IYF7 xref: UniProtKB:Q8WYF7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005830 ! TRIM37_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005829 ! dlg7-trim37 physical interaction relationship: participates_in CCO:I0005924 ! pbk-trim37 physical interaction relationship: transforms_into CCO:B0014534 ! TRI37_HUMAN-Phosphoserine771 relationship: transforms_into CCO:B0014535 ! TRI37_HUMAN-Phosphoserine773 [Term] id: CCO:B0005251 name: SCNM1_HUMAN def: "Sodium channel modifier 1" [UniProtKB:Q9BWG6] xref: EMBL:AAH00264.1 xref: EMBL:BAB71149.1 xref: EMBL:CAI16381.1 xref: EMBL:CAI16382.1 xref: UniProtKB:Q5JR74 xref: UniProtKB:Q9BWG6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005574 ! SCNM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005833 ! mcm6-scnm1 physical interaction [Term] id: CCO:B0005252 name: ZC11A_HUMAN def: "Zinc finger CCCH domain-containing protein 11A" [UniProtKB:O75152] xref: EMBL:AAH14268.1 xref: EMBL:AAH48271.1 xref: EMBL:BAA31638.2 xref: EMBL:CAH10525.1 xref: EMBL:CAH10530.1 xref: EMBL:CAH10553.1 xref: EMBL:CAH10566.1 xref: UniProtKB:O75152 xref: UniProtKB:Q6AHY4 xref: UniProtKB:Q6AHY9 xref: UniProtKB:Q6AW79 xref: UniProtKB:Q6AWA1 xref: UniProtKB:Q6PJK4 xref: UniProtKB:Q86XZ7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005953 ! ZC3H11A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005834 ! mlh1-zc3h11a physical interaction relationship: transforms_into CCO:B0014731 ! ZC11A_HUMAN-Phosphoserine108 relationship: transforms_into CCO:B0014732 ! ZC11A_HUMAN-Phosphoserine116 relationship: transforms_into CCO:B0014733 ! ZC11A_HUMAN-Phosphoserine132 relationship: transforms_into CCO:B0014734 ! ZC11A_HUMAN-Phosphoserine290 relationship: transforms_into CCO:B0014735 ! ZC11A_HUMAN-Phosphoserine495 relationship: transforms_into CCO:B0014736 ! ZC11A_HUMAN-Phosphoserine758 relationship: transforms_into CCO:B0014737 ! ZC11A_HUMAN-Phosphoserine759 relationship: transforms_into CCO:B0014738 ! ZC11A_HUMAN-Phosphoserine761 relationship: transforms_into CCO:B0014739 ! ZC11A_HUMAN-Phosphothreonine762 [Term] id: CCO:B0005253 name: TCPG_HUMAN def: "T-complex protein 1 subunit gamma" [UniProtKB:P49368] synonym: "CCT-gamma" EXACT [UniProtKB:P49368] synonym: "hTRiC5" EXACT [UniProtKB:P49368] synonym: "TCP-1-gamma" EXACT [UniProtKB:P49368] xref: EMBL:AAC50068.1 xref: EMBL:AAH06501.3 xref: EMBL:AAH08019.1 xref: EMBL:CAA52808.1 xref: EMBL:CAI14167.1 xref: EMBL:CAI46192.1 xref: UniProtKB:P49368 xref: UniProtKB:Q5SZY1 xref: UniProtKB:Q9BR64 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005753 ! CCT3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005836 ! cct3-sssca1 physical interaction relationship: transforms_into CCO:B0014324 ! TCPG_HUMAN-Phosphothreonine254 [Term] id: CCO:B0005255 name: EXOC8_HUMAN def: "Exocyst complex component 8" [UniProtKB:Q8IYI6] synonym: "Exocyst complex 84 kDa subunit" EXACT [UniProtKB:Q8IYI6] xref: EMBL:AAH35763.2 xref: EMBL:CAI23095.1 xref: UniProtKB:Q5TE82 xref: UniProtKB:Q8IYI6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004596 ! EXOC8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005839 ! exoc8-krt18 physical interaction relationship: transforms_into CCO:B0011809 ! EXOC8_HUMAN-Phosphoserine19 [Term] id: CCO:B0005256 name: HNRPG_HUMAN def: "Heterogeneous nuclear ribonucleoprotein G" [UniProtKB:P38159] synonym: "Glycoprotein p43" EXACT [UniProtKB:P38159] synonym: "hnRNP G" EXACT [UniProtKB:P38159] synonym: "RNA-binding motif protein, X chromosome" EXACT [UniProtKB:P38159] xref: EMBL:AAH06550.1 xref: EMBL:AAH07435.1 xref: EMBL:AAK58567.1 xref: EMBL:AAR28036.1 xref: EMBL:CAA80599.1 xref: EMBL:CAI39448.1 xref: UniProtKB:P38159 xref: UniProtKB:Q5JQ67 xref: UniProtKB:Q969R3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004820 ! RBMX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005840 ! rbm7-rbmx physical interaction relationship: transforms_into CCO:B0012234 ! HNRPG_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0012235 ! HNRPG_HUMAN-N-acetylvaline2 relationship: transforms_into CCO:B0012236 ! HNRPG_HUMAN-Phosphoserine58 relationship: transforms_into CCO:B0012237 ! HNRPG_HUMAN-Phosphoserine88 relationship: transforms_into CCO:B0012238 ! HNRPG_HUMAN-Phosphoserine165 relationship: transforms_into CCO:B0012239 ! HNRPG_HUMAN-Omega-N-methylated arginine185 relationship: transforms_into CCO:B0012240 ! HNRPG_HUMAN-Phosphoserine208 relationship: transforms_into CCO:B0012241 ! HNRPG_HUMAN-Phosphoserine330 relationship: transforms_into CCO:B0012242 ! HNRPG_HUMAN-Phosphoserine332 relationship: transforms_into CCO:B0012243 ! HNRPG_HUMAN-Phosphoserine352 [Term] id: CCO:B0005257 name: SAMD3_HUMAN def: "Sterile alpha motif domain-containing protein 3" [UniProtKB:Q8N6K7] xref: EMBL:AAH29851.1 xref: EMBL:AAI19758.1 xref: EMBL:AAI19759.1 xref: EMBL:BAC03644.1 xref: EMBL:BAC03765.1 xref: EMBL:CAI95328.1 xref: UniProtKB:Q4VXD8 xref: UniProtKB:Q8N6K7 xref: UniProtKB:Q8NAY1 xref: UniProtKB:Q8NB96 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005561 ! SAMD3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005841 ! fancg-samd3 physical interaction [Term] id: CCO:B0005258 name: DTBP1_HUMAN def: "Dysbindin" [UniProtKB:Q96EV8] synonym: "Dystrobrevin-binding protein 1" EXACT [UniProtKB:Q96EV8] synonym: "Hermansky-Pudlak syndrome 7 protein homolog" EXACT [UniProtKB:Q96EV8] synonym: "Hps7-like protein" EXACT [UniProtKB:Q96EV8] xref: EMBL:AAG43145.1 xref: EMBL:AAH11912.1 xref: EMBL:AAL46636.1 xref: EMBL:AAP91870.1 xref: EMBL:BAB70770.1 xref: EMBL:CAB66572.1 xref: EMBL:CAI21976.1 xref: EMBL:CAI21977.1 xref: EMBL:CAI42339.1 xref: EMBL:CAI42340.1 xref: UniProtKB:Q5THY3 xref: UniProtKB:Q5THY4 xref: UniProtKB:Q96EV8 xref: UniProtKB:Q96NV2 xref: UniProtKB:Q9H0U2 xref: UniProtKB:Q9H3J5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004515 ! DTNBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005842 ! ccnd3-dtnbp1 physical interaction relationship: participates_in CCO:I0006570 ! dtnbp1-ccna2 physical interaction relationship: participates_in CCO:I0006581 ! dtnbp1-bpag1 physical interaction relationship: participates_in CCO:I0006593 ! dtnbp1-macf1 physical interaction relationship: participates_in CCO:I0008760 ! dtnbp1-psme3 physical interaction [Term] id: CCO:B0005259 name: VTA1_HUMAN def: "Vacuolar protein sorting-associated protein VTA1 homolog" [UniProtKB:Q9NP79] synonym: "Dopamine-responsive protein DRG-1" EXACT [UniProtKB:Q9NP79] xref: EMBL:AAF36148.1 xref: EMBL:AAF76210.1 xref: EMBL:AAG43125.1 xref: EMBL:AAH05937.1 xref: EMBL:AAH06989.1 xref: EMBL:AAH22536.1 xref: EMBL:BAA90909.1 xref: EMBL:CAB66619.1 xref: EMBL:CAG33488.1 xref: EMBL:CAI21072.1 xref: UniProtKB:Q5TGM1 xref: UniProtKB:Q6IAE8 xref: UniProtKB:Q9H0R2 xref: UniProtKB:Q9H3K9 xref: UniProtKB:Q9NP79 xref: UniProtKB:Q9P0Q0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005908 ! VTA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005844 ! c6orf55-sssca1 physical interaction relationship: participates_in CCO:I0005885 ! c6orf55-cdk4 physical interaction [Term] id: CCO:B0005260 name: NIF3L_HUMAN def: "NIF3-like protein 1" [UniProtKB:Q9GZT8] synonym: "Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein" EXACT [UniProtKB:Q9GZT8] xref: EMBL:AAG14952.1 xref: EMBL:AAG43131.1 xref: EMBL:AAG44846.1 xref: EMBL:AAH07654.1 xref: EMBL:BAB14551.1 xref: EMBL:BAB32499.1 xref: UniProtKB:Q9GZT8 xref: UniProtKB:Q9H2D2 xref: UniProtKB:Q9HC18 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005194 ! NIF3L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005846 ! mapre2-nif3l1 physical interaction [Term] id: CCO:B0005262 name: CJ119_HUMAN def: "UPF0557 protein C10orf119" [UniProtKB:Q9BTE3] xref: EMBL:AAH00935.1 xref: EMBL:AAH04183.1 xref: EMBL:AAH07219.1 xref: EMBL:BAB14427.1 xref: EMBL:CAG33580.1 xref: UniProtKB:Q6IA56 xref: UniProtKB:Q9BTE3 xref: UniProtKB:Q9BVT9 xref: UniProtKB:Q9H916 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004357 ! C10orf119_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005849 ! c10orf119-ddit3 physical interaction relationship: transforms_into CCO:B0011225 ! CJ119_HUMAN-Phosphoserine154 relationship: transforms_into CCO:B0011226 ! CJ119_HUMAN-Phosphothreonine160 [Term] id: CCO:B0005263 name: ZN567_HUMAN def: "Zinc finger protein 567" [UniProtKB:Q8N184] xref: EMBL:AAH33849.2 xref: EMBL:CAE45826.1 xref: UniProtKB:Q6N044 xref: UniProtKB:Q8N184 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005963 ! ZNF567_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005850 ! mltk-znf567 physical interaction [Term] id: CCO:B0005264 name: PHC1_HUMAN def: "Polyhomeotic-like protein 1" [UniProtKB:P78364] synonym: "Early development regulatory protein 1" EXACT [UniProtKB:P78364] synonym: "hPH1" EXACT [UniProtKB:P78364] xref: EMBL:AAC51169.1 xref: EMBL:AAH02871.2 xref: EMBL:AAH17748.1 xref: UniProtKB:P78364 xref: UniProtKB:Q8WVM3 xref: UniProtKB:Q9BU63 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005307 ! PHC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005851 ! phc1-ube2i physical interaction [Term] id: CCO:B0005265 name: DYRK2_HUMAN def: "Dual specificity tyrosine-phosphorylation-regulated kinase 2" [UniProtKB:Q92630] synonym: "EC 2.7.12.1" EXACT [UniProtKB:Q92630] xref: EMBL:AAH05809.1 xref: EMBL:AAH06375.1 xref: EMBL:CAA70418.1 xref: EMBL:CAA73885.1 xref: UniProtKB:Q92630 xref: UniProtKB:Q9BRB5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004529 ! DYRK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005852 ! dyrk2-rad54b physical interaction [Term] id: CCO:B0005267 name: FRMD6_HUMAN def: "FERM domain-containing protein 6" [UniProtKB:Q96NE9] synonym: "Willin" EXACT [UniProtKB:Q96NE9] xref: EMBL:AAH20521.1 xref: EMBL:AAH29870.1 xref: EMBL:BAB70950.1 xref: EMBL:CAD61902.1 xref: EMBL:CAI46062.1 xref: UniProtKB:Q5HYF2 xref: UniProtKB:Q8N2X1 xref: UniProtKB:Q8WUH7 xref: UniProtKB:Q96NE9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004660 ! FRMD6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005854 ! frmd6-mlh1 physical interaction relationship: transforms_into CCO:B0011898 ! FRMD6_HUMAN-Phosphoserine522 relationship: transforms_into CCO:B0011899 ! FRMD6_HUMAN-Phosphoserine525 [Term] id: CCO:B0005268 name: ASF1A_HUMAN def: "Histone chaperone ASF1A" [UniProtKB:Q9Y294] synonym: "Anti-silencing function protein 1 homolog A" EXACT [UniProtKB:Q9Y294] synonym: "CCG1-interacting factor A" EXACT [UniProtKB:Q9Y294] synonym: "CIA" EXACT [UniProtKB:Q9Y294] synonym: "hAsf1" EXACT [UniProtKB:Q9Y294] synonym: "hAsf1a" EXACT [UniProtKB:Q9Y294] synonym: "hCIA" EXACT [UniProtKB:Q9Y294] xref: EMBL:AAD34093.1 xref: EMBL:AAF29110.1 xref: EMBL:AAH10878.1 xref: EMBL:AAK82972.1 xref: EMBL:BAA96542.1 xref: EMBL:BAB15228.1 xref: EMBL:CAB43363.1 xref: EMBL:CAG33628.1 xref: UniProtKB:Q6IA08 xref: UniProtKB:Q9P014 xref: UniProtKB:Q9Y294 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004106 ! ASF1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005855 ! dkfzp564e2182-tlk1 physical interaction [Term] id: CCO:B0005269 name: Q96AF5_HUMAN def: "ZNF446 protein" [UniProtKB:Q96AF5] xref: EMBL:AAH17206.1 xref: UniProtKB:Q96AF5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006034 ! ZNF446_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005856 ! sufu-znf446 physical interaction [Term] id: CCO:B0005270 name: CHM4B_HUMAN def: "Charged multivesicular body protein 4b" [UniProtKB:Q9H444] synonym: "CHMP4b" EXACT [UniProtKB:Q9H444] synonym: "Chromatin-modifying protein 4b" EXACT [UniProtKB:Q9H444] synonym: "hSnf7-2" EXACT [UniProtKB:Q9H444] synonym: "hVps32" EXACT [UniProtKB:Q9H444] synonym: "SNF7 homolog associated with Alix 1" EXACT [UniProtKB:Q9H444] synonym: "SNF7-2" EXACT [UniProtKB:Q9H444] synonym: "Vacuolar protein-sorting-associated protein 7-2" EXACT [UniProtKB:Q9H444] xref: EMBL:AAH33859.1 xref: EMBL:AAQ91194.1 xref: EMBL:BAC79375.1 xref: EMBL:CAC14088.1 xref: UniProtKB:Q53ZD6 xref: UniProtKB:Q9H444 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004350 ! CHMP4B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005857 ! chmp4b-ube2i physical interaction [Term] id: CCO:B0005271 name: MBIP1_HUMAN def: "MAP3K12-binding inhibitory protein 1" [UniProtKB:Q9NS73] synonym: "MAPK upstream kinase-binding inhibitory protein" EXACT [UniProtKB:Q9NS73] synonym: "MUK-binding inhibitory protein" EXACT [UniProtKB:Q9NS73] xref: EMBL:AAF64271.1 xref: EMBL:AAH05197.1 xref: EMBL:AAH16821.1 xref: EMBL:BAA94083.1 xref: EMBL:CAD62615.1 xref: UniProtKB:Q86TZ2 xref: UniProtKB:Q96AS5 xref: UniProtKB:Q9BS93 xref: UniProtKB:Q9NS73 xref: UniProtKB:Q9NZE1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005035 ! MBIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005858 ! mbip-mcm7 physical interaction [Term] id: CCO:B0005272 name: KC1E_HUMAN def: "Casein kinase I isoform epsilon" [UniProtKB:P49674] synonym: "CKI-epsilon" EXACT [UniProtKB:P49674] synonym: "CKIe" EXACT [UniProtKB:P49674] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P49674] xref: EMBL:AAC41761.1 xref: EMBL:AAH06490.1 xref: EMBL:BAA92345.1 xref: EMBL:BAC10902.1 xref: EMBL:CAA15888.1 xref: EMBL:CAG30315.1 xref: UniProtKB:P49674 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004932 ! CSNK1E_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005861 ! csnk1e-rad54b physical interaction relationship: participates_in CCO:I0006260 ! csnk1e-apc phosphorylation relationship: transforms_into CCO:B0012511 ! KC1E_HUMAN-Phosphothreonine362 relationship: transforms_into CCO:B0012512 ! KC1E_HUMAN-Phosphoserine363 [Term] id: CCO:B0005273 name: TOLIP_HUMAN def: "Toll-interacting protein" [UniProtKB:Q9H0E2] xref: EMBL:AAH04420.1 xref: EMBL:AAH12057.1 xref: EMBL:AAH18272.1 xref: EMBL:BAB14283.1 xref: EMBL:CAB58118.1 xref: EMBL:CAB66769.1 xref: UniProtKB:Q9H0E2 xref: UniProtKB:Q9H9E6 xref: UniProtKB:Q9UJ69 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005808 ! TOLLIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005863 ! sept1-tollip physical interaction [Term] id: CCO:B0005274 name: RHXF2_HUMAN def: "Rhox homeobox family member 2" [UniProtKB:Q9BQY4] synonym: "Paired-like homeobox protein PEPP-2" EXACT [UniProtKB:Q9BQY4] synonym: "Testis homeobox gene 1" EXACT [UniProtKB:Q9BQY4] xref: EMBL:AAH21719.1 xref: EMBL:AAL02160.1 xref: EMBL:BAB71675.1 xref: EMBL:CAC36517.1 xref: EMBL:CAC36519.1 xref: UniProtKB:Q9BQY4 xref: UniProtKB:Q9BR00 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005486 ! RHOXF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005864 ! lzts2-pepp2 physical interaction relationship: participates_in CCO:I0005884 ! ccnk-pepp2 physical interaction relationship: participates_in CCO:I0006503 ! rent1-pepp2 physical interaction [Term] id: CCO:B0005275 name: KHDR3_HUMAN def: "KH domain-containing, RNA-binding, signal transduction-associated protein 3" [UniProtKB:O75525] synonym: "RNA-binding protein T-Star" EXACT [UniProtKB:O75525] synonym: "Sam68-like mammalian protein 2" EXACT [UniProtKB:O75525] synonym: "Sam68-like phosphotyrosine protein" EXACT [UniProtKB:O75525] synonym: "SLM-2" EXACT [UniProtKB:O75525] xref: EMBL:AAC24857.1 xref: EMBL:AAC99294.1 xref: EMBL:AAC99295.1 xref: EMBL:AAH32606.1 xref: EMBL:AAH68536.1 xref: UniProtKB:O75525 xref: UniProtKB:Q6NUL8 xref: UniProtKB:Q9UPA8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004938 ! KHDRBS3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005865 ! khdrbs3-rbm7 physical interaction relationship: participates_in CCO:I0005945 ! khdrbs3-siah1 physical interaction relationship: transforms_into CCO:B0012528 ! KHDR3_HUMAN-Phosphotyrosine5 [Term] id: CCO:B0005276 name: ZN764_HUMAN def: "Zinc finger protein 764" [UniProtKB:Q96H86] xref: EMBL:AAH00016.2 xref: EMBL:AAH08821.1 xref: UniProtKB:Q96H86 xref: UniProtKB:Q9BWS1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005967 ! ZNF764_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005866 ! mgc13138-sufu physical interaction [Term] id: CCO:B0005278 name: UBCP1_HUMAN def: "Ubiquitin-like domain-containing CTD phosphatase 1" [UniProtKB:Q8WVY7] synonym: "EC 3.1.3.16" EXACT [UniProtKB:Q8WVY7] xref: EMBL:AAH13425.2 xref: EMBL:AAS68538.1 xref: EMBL:BAB71628.1 xref: UniProtKB:Q8WVY7 xref: UniProtKB:Q96DK5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005859 ! UBLCP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005870 ! psmd2-ublcp1 physical interaction [Term] id: CCO:B0005279 name: TBC17_HUMAN def: "TBC1 domain family member 17" [UniProtKB:Q9HA65] xref: EMBL:AAH03516.1 xref: EMBL:BAB13991.1 xref: UniProtKB:Q9HA65 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005738 ! TBC1D17_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005871 ! cdkn2d-tbc1d17 physical interaction relationship: participates_in CCO:I0008479 ! gps1-tbc1d17 physical interaction [Term] id: CCO:B0005280 name: HGS_HUMAN def: "Hepatocyte growth factor-regulated tyrosine kinase substrate" [UniProtKB:O14964] synonym: "Hrs" EXACT [UniProtKB:O14964] synonym: "Protein pp110" EXACT [UniProtKB:O14964] xref: EMBL:AAC51929.1 xref: EMBL:AAF82361.1 xref: EMBL:AAH03565.1 xref: EMBL:AAP88756.1 xref: EMBL:BAA23366.1 xref: UniProtKB:O14964 xref: UniProtKB:Q9NR36 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004804 ! HGS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005873 ! hgs-ube2i physical interaction relationship: participates_in CCO:I0005902 ! hgs-krt18 physical interaction relationship: participates_in CCO:I0007649 ! gfi1b-hgs physical interaction relationship: transforms_into CCO:B0012185 ! HGS_HUMAN-Phosphotyrosine216 relationship: transforms_into CCO:B0012186 ! HGS_HUMAN-Phosphotyrosine308 relationship: transforms_into CCO:B0012187 ! HGS_HUMAN-Phosphotyrosine329 relationship: transforms_into CCO:B0012188 ! HGS_HUMAN-Phosphotyrosine334 [Term] id: CCO:B0005281 name: M1IP1_HUMAN def: "Mid1-interacting protein 1" [UniProtKB:Q9NPA3] synonym: "Gastrulation-specific G12-like protein" EXACT [UniProtKB:Q9NPA3] synonym: "Mid1-interacting G12-like protein" EXACT [UniProtKB:Q9NPA3] synonym: "Protein STRAIT11499" EXACT [UniProtKB:Q9NPA3] xref: EMBL:AAH08908.1 xref: EMBL:AAH19332.1 xref: EMBL:BAA91580.1 xref: EMBL:CAB89113.1 xref: EMBL:CAG33501.1 xref: EMBL:DAA01482.1 xref: UniProtKB:Q9NPA3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005002 ! MID1IP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005877 ! mid1ip1-sufu physical interaction relationship: transforms_into CCO:B0012713 ! M1IP1_HUMAN-Phosphoserine75 [Term] id: CCO:B0005282 name: NOC4L_HUMAN def: "Nucleolar complex protein 4 homolog" [UniProtKB:Q9BVI4] synonym: "NOC4 protein homolog" EXACT [UniProtKB:Q9BVI4] synonym: "NOC4-like protein" EXACT [UniProtKB:Q9BVI4] synonym: "Nucleolar complex-associated protein 4-like protein" EXACT [UniProtKB:Q9BVI4] xref: EMBL:AAH01191.1 xref: EMBL:AAH07893.2 xref: EMBL:AAH71958.1 xref: EMBL:BAC11020.1 xref: UniProtKB:Q8N2S5 xref: UniProtKB:Q96I14 xref: UniProtKB:Q9BVI4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005201 ! NOC4L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005879 ! mgc3162-sssca1 physical interaction [Term] id: CCO:B0005283 name: TS101_HUMAN def: "Tumor susceptibility gene 101 protein" [UniProtKB:Q99816] xref: EMBL:AAC52083.1 xref: EMBL:AAH02487.1 xref: UniProtKB:Q99816 xref: UniProtKB:Q9BUM5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005838 ! TSG101_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005880 ! c10orf3-tsg101 physical interaction [Term] id: CCO:B0005284 name: ING5_HUMAN def: "Inhibitor of growth protein 5" [UniProtKB:Q8WYH8] synonym: "p28ING5" EXACT [UniProtKB:Q8WYH8] xref: EMBL:AAH05370.1 xref: EMBL:AAH71899.1 xref: EMBL:AAL68979.1 xref: EMBL:BAB85078.1 xref: UniProtKB:Q8WYH8 xref: UniProtKB:Q9BS30 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004895 ! ING5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005883 ! ing5-mcm6 physical interaction relationship: transforms_into CCO:B0012418 ! ING5_HUMAN-Phosphoserine118 [Term] id: CCO:B0005285 name: H32_HUMAN def: "Histone H3.2" [UniProtKB:Q71DI3] synonym: "H3/m" EXACT [UniProtKB:Q71DI3] synonym: "H3/o" EXACT [UniProtKB:Q71DI3] xref: EMBL:AAH74969.2 xref: EMBL:AAN39283.1 xref: EMBL:AAT68254.1 xref: EMBL:CAI12559.1 xref: EMBL:CAI12561.1 xref: EMBL:CAI12566.1 xref: UniProtKB:Q6B053 xref: UniProtKB:Q71DI3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004759 ! HIST2H3A_human relationship: encoded_by CCO:G0004760 ! HIST2H3C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005886 ! hist2h3c-nasp physical interaction relationship: transforms_into CCO:B0012060 ! H32_HUMAN-Phosphothreonine4 relationship: transforms_into CCO:B0012061 ! H32_HUMAN-N6-acetyllysine5 relationship: transforms_into CCO:B0012062 ! H32_HUMAN-N6-methyllysine5 relationship: transforms_into CCO:B0012063 ! H32_HUMAN-Citrulline9 relationship: transforms_into CCO:B0012064 ! H32_HUMAN-dimethylarginine9 relationship: transforms_into CCO:B0012065 ! H32_HUMAN-N6,N6,N6-trimethyllysine10 relationship: transforms_into CCO:B0012066 ! H32_HUMAN-N6,N6-dimethyllysine10 relationship: transforms_into CCO:B0012067 ! H32_HUMAN-N6-acetyllysine10 relationship: transforms_into CCO:B0012068 ! H32_HUMAN-N6-methyllysine10 relationship: transforms_into CCO:B0012069 ! H32_HUMAN-Phosphoserine11 relationship: transforms_into CCO:B0012070 ! H32_HUMAN-Phosphothreonine12 relationship: transforms_into CCO:B0012071 ! H32_HUMAN-N6-acetyllysine15 relationship: transforms_into CCO:B0012072 ! H32_HUMAN-dimethylarginine18 relationship: transforms_into CCO:B0012073 ! H32_HUMAN-Citrulline18 relationship: transforms_into CCO:B0012074 ! H32_HUMAN-N6-acetyllysine19 relationship: transforms_into CCO:B0012075 ! H32_HUMAN-N6-methyllysine19 relationship: transforms_into CCO:B0012076 ! H32_HUMAN-N6-acetyllysine24 relationship: transforms_into CCO:B0012077 ! H32_HUMAN-N6-methyllysine24 relationship: transforms_into CCO:B0012078 ! H32_HUMAN-N6,N6,N6-trimethyllysine28 relationship: transforms_into CCO:B0012079 ! H32_HUMAN-N6,N6-dimethyllysine28 relationship: transforms_into CCO:B0012080 ! H32_HUMAN-N6-acetyllysine28 relationship: transforms_into CCO:B0012081 ! H32_HUMAN-N6-methyllysine28 relationship: transforms_into CCO:B0012082 ! H32_HUMAN-Phosphoserine29 relationship: transforms_into CCO:B0012083 ! H32_HUMAN-N6,N6,N6-trimethyllysine37 relationship: transforms_into CCO:B0012084 ! H32_HUMAN-N6,N6-dimethyllysine37 relationship: transforms_into CCO:B0012085 ! H32_HUMAN-N6-acetyllysine37 relationship: transforms_into CCO:B0012086 ! H32_HUMAN-N6-methyllysine37 relationship: transforms_into CCO:B0012087 ! H32_HUMAN-N6,N6,N6-trimethyllysine57 relationship: transforms_into CCO:B0012088 ! H32_HUMAN-N6-acetyllysine57 relationship: transforms_into CCO:B0012089 ! H32_HUMAN-N6-methyllysine57 relationship: transforms_into CCO:B0012090 ! H32_HUMAN-N6-methyllysine65 relationship: transforms_into CCO:B0012091 ! H32_HUMAN-N6,N6,N6-trimethyllysine80 relationship: transforms_into CCO:B0012092 ! H32_HUMAN-N6,N6-dimethyllysine80 relationship: transforms_into CCO:B0012093 ! H32_HUMAN-N6-acetyllysine80 relationship: transforms_into CCO:B0012094 ! H32_HUMAN-N6-methyllysine80 relationship: transforms_into CCO:B0012095 ! H32_HUMAN-N6-methyllysine123 [Term] id: CCO:B0005286 name: CN048_HUMAN def: "Uncharacterized protein C14orf48" [UniProtKB:Q8NCU1] xref: EMBL:AAH21728.1 xref: EMBL:BAC05156.1 xref: UniProtKB:Q8N7S1 xref: UniProtKB:Q8NCU1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004374 ! C14orf48_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005888 ! c14orf48-c18orf24 physical interaction [Term] id: CCO:B0005288 name: ARI2_HUMAN def: "Protein ariadne-2 homolog" [UniProtKB:O95376] synonym: "ARI-2" EXACT [UniProtKB:O95376] synonym: "Triad1 protein" EXACT [UniProtKB:O95376] xref: EMBL:AAC82469.1 xref: EMBL:AAG09696.1 xref: EMBL:AAH00422.1 xref: EMBL:CAA10276.1 xref: UniProtKB:O95376 xref: UniProtKB:Q9HBZ6 xref: UniProtKB:Q9UEM9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004092 ! ARIH2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005890 ! arih2-bub1 physical interaction relationship: participates_in CCO:I0007995 ! arih2-tp53 physical interaction relationship: participates_in CCO:I0008066 ! arih2-centd2 physical interaction relationship: participates_in CCO:I0008357 ! arih2-eml4 physical interaction relationship: transforms_into CCO:B0010601 ! ARI2_HUMAN-Phosphoserine353 [Term] id: CCO:B0005289 name: Q8NHQ3_HUMAN def: "RBBP8 protein" [UniProtKB:Q8NHQ3] xref: EMBL:AAH30590.1 xref: UniProtKB:Q8NHQ3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005442 ! RBBP8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005891 ! pin1-rbbp8 physical interaction [Term] id: CCO:B0005290 name: F131C_HUMAN def: "Protein FAM131C" [UniProtKB:Q96AQ9] xref: EMBL:AAH16848.1 xref: EMBL:AAH37394.1 xref: EMBL:BAC04282.1 xref: EMBL:CAI16143.1 xref: UniProtKB:Q5T5Q5 xref: UniProtKB:Q8N3X3 xref: UniProtKB:Q8N9P9 xref: UniProtKB:Q96AQ9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004604 ! FAM131C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005894 ! c1orf117-mad1l1 physical interaction [Term] id: CCO:B0005291 name: TCPE_HUMAN def: "T-complex protein 1 subunit epsilon" [UniProtKB:P48643] synonym: "CCT-epsilon" EXACT [UniProtKB:P48643] synonym: "TCP-1-epsilon" EXACT [UniProtKB:P48643] xref: EMBL:AAH06543.1 xref: EMBL:AAH35499.1 xref: EMBL:BAA07894.2 xref: UniProtKB:P48643 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005752 ! CCT5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005895 ! cct5-sssca1 physical interaction relationship: participates_in CCO:I0008076 ! cct5-tp53 physical interaction relationship: transforms_into CCO:B0041344 ! TCPE_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005292 name: SPOP_HUMAN def: "Speckle-type POZ protein" [UniProtKB:O43791] synonym: "HIB homolog 1" EXACT [UniProtKB:O43791] synonym: "Roadkill homolog 1" EXACT [UniProtKB:O43791] xref: EMBL:AAH01269.1 xref: EMBL:AAH03385.1 xref: EMBL:BAD96309.1 xref: EMBL:CAA04199.1 xref: UniProtKB:O43791 xref: UniProtKB:Q53HJ1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005665 ! SPOP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005896 ! ddit3-spop physical interaction [Term] id: CCO:B0005293 name: KR412_HUMAN def: "Keratin-associated protein 4-12" [UniProtKB:Q9BQ66] synonym: "Keratin-associated protein 4.12" EXACT [UniProtKB:Q9BQ66] synonym: "Ultrahigh sulfur keratin-associated protein 4.12" EXACT [UniProtKB:Q9BQ66] xref: EMBL:AAH04180.1 xref: EMBL:AAH04212.1 xref: EMBL:AAI01160.1 xref: EMBL:AAI01161.1 xref: EMBL:AAI01163.1 xref: EMBL:CAC27582.1 xref: UniProtKB:A3KMC5 xref: UniProtKB:Q495I0 xref: UniProtKB:Q9BQ66 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004960 ! KRTAP4-12_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005900 ! ccnk-krtap4_12 physical interaction [Term] id: CCO:B0005294 name: NDK7_HUMAN def: "Nucleoside diphosphate kinase 7" [UniProtKB:Q9Y5B8] synonym: "EC 2.7.4.6" EXACT [UniProtKB:Q9Y5B8] synonym: "NDK 7" EXACT [UniProtKB:Q9Y5B8] synonym: "NDP kinase 7" EXACT [UniProtKB:Q9Y5B8] synonym: "nm23-H7" EXACT [UniProtKB:Q9Y5B8] xref: EMBL:AAD34622.1 xref: EMBL:AAH06983.1 xref: EMBL:CAI18887.1 xref: EMBL:CAI19238.1 xref: EMBL:CAI22851.1 xref: UniProtKB:Q5TGZ4 xref: UniProtKB:Q9Y5B8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005166 ! NME7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005903 ! krt18-nme7 physical interaction [Term] id: CCO:B0005295 name: PCTK3_HUMAN def: "Serine/threonine-protein kinase PCTAIRE-3" [UniProtKB:Q07002] synonym: "EC 2.7.11.22" EXACT [UniProtKB:Q07002] synonym: "PCTAIRE-motif protein kinase 3" EXACT [UniProtKB:Q07002] xref: EMBL:AAH11526.1 xref: EMBL:AAP35963.1 xref: EMBL:CAA47005.1 xref: EMBL:CAH72012.1 xref: UniProtKB:Q07002 xref: UniProtKB:Q5VXQ2 xref: UniProtKB:Q96F90 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005283 ! PCTK3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005904 ! ccnk-pctk3 physical interaction relationship: transforms_into CCO:B0013446 ! PCTK3_HUMAN-Phosphoserine12 relationship: transforms_into CCO:B0013447 ! PCTK3_HUMAN-Phosphoserine87 relationship: transforms_into CCO:B0013448 ! PCTK3_HUMAN-Phosphoserine130 relationship: transforms_into CCO:B0013449 ! PCTK3_HUMAN-Phosphoserine132 [Term] id: CCO:B0005296 name: HM20A_HUMAN def: "High mobility group protein 20A" [UniProtKB:Q9NP66] synonym: "HMG box-containing protein 20A" EXACT [UniProtKB:Q9NP66] synonym: "HMG domain-containing protein HMGX1" EXACT [UniProtKB:Q9NP66] xref: EMBL:AAF66706.1 xref: EMBL:AAH21959.1 xref: EMBL:AAP35362.1 xref: EMBL:BAA91782.1 xref: EMBL:BAD96820.1 xref: EMBL:CAB90815.1 xref: EMBL:CAB90816.1 xref: EMBL:EAW99201.1 xref: UniProtKB:A6NHY3 xref: UniProtKB:Q53G31 xref: UniProtKB:Q9NP66 xref: UniProtKB:Q9NSF6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004810 ! HMG20A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005906 ! hmg20a-rbm7 physical interaction relationship: participates_in CCO:I0005910 ! ccnk-hmg20a physical interaction [Term] id: CCO:B0005297 name: ZN263_HUMAN def: "Zinc finger protein 263" [UniProtKB:O14978] synonym: "Zinc finger protein FPM315" EXACT [UniProtKB:O14978] synonym: "Zinc finger protein with KRAB and SCAN domains 12" EXACT [UniProtKB:O14978] xref: EMBL:AAC24490.1 xref: EMBL:AAH08805.1 xref: EMBL:BAA21853.1 xref: UniProtKB:O14978 xref: UniProtKB:O43387 xref: UniProtKB:Q96H95 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005958 ! ZNF263_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005907 ! sufu-znf263 physical interaction [Term] id: CCO:B0005298 name: KAP0_HUMAN def: "cAMP-dependent protein kinase type I-alpha regulatory subunit" [UniProtKB:P10644] synonym: "Tissue-specific extinguisher 1" EXACT [UniProtKB:P10644] synonym: "TSE1" EXACT [UniProtKB:P10644] xref: EMBL:AAB50921.1 xref: EMBL:AAB50922.1 xref: EMBL:AAH36285.1 xref: EMBL:AAH93042.1 xref: EMBL:CAA68925.1 xref: UniProtKB:P10644 xref: UniProtKB:Q567S7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004930 ! PRKAR1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005908 ! prkar1a-pycard physical interaction relationship: transforms_into CCO:B0012507 ! KAP0_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0012508 ! KAP0_HUMAN-Phosphoserine77 relationship: transforms_into CCO:B0012509 ! KAP0_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0012510 ! KAP0_HUMAN-Phosphoserine101 [Term] id: CCO:B0005299 name: AMOL2_HUMAN def: "Angiomotin-like protein 2" [UniProtKB:Q9Y2J4] synonym: "LCCP" EXACT [UniProtKB:Q9Y2J4] synonym: "Leman coiled-coil protein" EXACT [UniProtKB:Q9Y2J4] xref: EMBL:AAD56361.2 xref: EMBL:AAH11454.1 xref: EMBL:BAA76833.1 xref: EMBL:BAD97318.1 xref: UniProtKB:Q53EP1 xref: UniProtKB:Q96F99 xref: UniProtKB:Q9UKB4 xref: UniProtKB:Q9Y2J4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004050 ! AMOTL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005911 ! amotl2-kntc2 physical interaction relationship: participates_in CCO:I0005912 ! amotl2-mad1l1 physical interaction [Term] id: CCO:B0005300 name: TAK1L_HUMAN def: "TAK1-like protein" [UniProtKB:P57077] xref: EMBL:AAF81751.1 xref: EMBL:AAF81752.1 xref: EMBL:AAF81753.1 xref: EMBL:AAF81754.1 xref: EMBL:AAH08567.1 xref: EMBL:AAK68718.1 xref: EMBL:AAO16519.1 xref: EMBL:CAB90434.1 xref: UniProtKB:P57077 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005728 ! TAK1L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005914 ! gps2-tak1l physical interaction relationship: participates_in CCO:I0007891 ! tak1l-gps2 physical interaction [Term] id: CCO:B0005301 name: MAF1_HUMAN def: "Repressor of RNA polymerase III transcription MAF1 homolog" [UniProtKB:Q9H063] xref: EMBL:AAH14082.1 xref: EMBL:AAH18714.1 xref: EMBL:AAH31273.1 xref: EMBL:CAB66871.1 xref: EMBL:CAG38494.1 xref: UniProtKB:Q9H063 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005015 ! MAF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005916 ! ccnd3-maf1 physical interaction relationship: transforms_into CCO:B0012759 ! MAF1_HUMAN-Phosphoserine75 [Term] id: CCO:B0005302 name: CTDS1_HUMAN def: "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1" [UniProtKB:Q9GZU7] synonym: "EC 3.1.3.16" EXACT [UniProtKB:Q9GZU7] synonym: "NLI-IF" EXACT [UniProtKB:Q9GZU7] synonym: "NLI-interacting factor 3" EXACT [UniProtKB:Q9GZU7] synonym: "Nuclear LIM interactor-interacting factor 3" EXACT [UniProtKB:Q9GZU7] xref: EMBL:AAG15402.1 xref: EMBL:AAG15404.1 xref: EMBL:AAH12977.1 xref: UniProtKB:Q9GZU7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004415 ! CTDSP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005917 ! cdca3-ctdsp1 physical interaction [Term] id: CCO:B0005303 name: Q8IVB0_HUMAN def: "Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila); translocated to, 3" [UniProtKB:Q8IVB0] xref: EMBL:AAH36089.1 xref: UniProtKB:Q8IVB0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004035 ! MLLT3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005918 ! mcm6-mllt3 physical interaction [Term] id: CCO:B0005305 name: LNX1_HUMAN def: "E3 ubiquitin-protein ligase LNX" [UniProtKB:Q8TBB1] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q8TBB1] synonym: "Ligand of Numb-protein X 1" EXACT [UniProtKB:Q8TBB1] synonym: "Numb-binding protein 1" EXACT [UniProtKB:Q8TBB1] xref: EMBL:AAH22983.1 xref: EMBL:AAH34737.1 xref: EMBL:AAK15039.1 xref: EMBL:AAQ88692.1 xref: EMBL:AAY41000.1 xref: EMBL:BAB71291.1 xref: UniProtKB:Q4W5K7 xref: UniProtKB:Q8N4C2 xref: UniProtKB:Q8TBB1 xref: UniProtKB:Q96MJ7 xref: UniProtKB:Q9BY20 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004985 ! LNX1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005923 ! lnx-rad54b physical interaction [Term] id: CCO:B0005308 name: ZN451_HUMAN def: "Zinc finger protein 451" [UniProtKB:Q9Y4E5] synonym: "Coactivator for steroid receptors" EXACT [UniProtKB:Q9Y4E5] xref: EMBL:AAH21712.2 xref: EMBL:AAL17975.1 xref: EMBL:BAA25502.1 xref: EMBL:CAH71220.1 xref: EMBL:CAI20516.1 xref: UniProtKB:Q5VVF1 xref: UniProtKB:Q8N380 xref: UniProtKB:Q8TD15 xref: UniProtKB:Q9NQM1 xref: UniProtKB:Q9Y4E5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005961 ! ZNF451_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005928 ! ube2i-znf451 physical interaction [Term] id: CCO:B0005309 name: RNF37_HUMAN def: "RING finger protein 37" [UniProtKB:O94941] synonym: "U-box domain-containing protein 5" EXACT [UniProtKB:O94941] synonym: "Ubiquitin-conjugating enzyme 7-interacting protein 5" EXACT [UniProtKB:O94941] xref: EMBL:AAH00515.1 xref: EMBL:BAA74883.2 xref: EMBL:CAC09909.1 xref: UniProtKB:O94941 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005521 ! UBOX5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005931 ! mlh1-ubox5 physical interaction [Term] id: CCO:B0005312 name: PEX26_HUMAN def: "Peroxisome assembly protein 26" [UniProtKB:Q7Z412] synonym: "Peroxin-26" EXACT [UniProtKB:Q7Z412] xref: EMBL:AAH16280.1 xref: EMBL:AAH47320.1 xref: EMBL:BAA90920.1 xref: EMBL:BAA91329.1 xref: EMBL:BAC66616.1 xref: EMBL:BAC78804.1 xref: EMBL:BAC78805.1 xref: EMBL:BAC78806.1 xref: EMBL:BAC78807.1 xref: EMBL:BAC78808.1 xref: EMBL:CAG30248.1 xref: UniProtKB:Q7Z412 xref: UniProtKB:Q7Z413 xref: UniProtKB:Q7Z414 xref: UniProtKB:Q7Z415 xref: UniProtKB:Q7Z416 xref: UniProtKB:Q96B12 xref: UniProtKB:Q9NWQ0 xref: UniProtKB:Q9NXU0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005300 ! PEX26_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005936 ! pex26-sufu physical interaction relationship: participates_in CCO:I0007890 ! pex26-sufu-1 physical interaction [Term] id: CCO:B0005314 name: PRS4_HUMAN def: "26S protease regulatory subunit 4" [UniProtKB:P62191] synonym: "P26s4" EXACT [UniProtKB:P62191] synonym: "Proteasome 26S subunit ATPase 1" EXACT [UniProtKB:P62191] xref: EMBL:AAA35484.1 xref: EMBL:AAH00512.1 xref: EMBL:AAH16368.1 xref: EMBL:AAH73818.1 xref: EMBL:CAG33325.1 xref: UniProtKB:P49014 xref: UniProtKB:P62191 xref: UniProtKB:Q03527 xref: UniProtKB:Q6IAW0 xref: UniProtKB:Q96AZ3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005384 ! PSMC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005939 ! psmc1-psmd2 physical interaction relationship: participates_in CCO:I0008714 ! traf6-psmc1 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0013617 ! PRS4_HUMAN-Phosphotyrosine439 [Term] id: CCO:B0005315 name: KPCZ_HUMAN def: "Protein kinase C zeta type" [UniProtKB:Q05513] synonym: "EC 2.7.11.13" EXACT [UniProtKB:Q05513] synonym: "nPKC-zeta" EXACT [UniProtKB:Q05513] xref: EMBL:AAA36488.1 xref: EMBL:AAH08058.1 xref: EMBL:AAH14270.1 xref: EMBL:AAP35745.1 xref: EMBL:CAA78813.1 xref: EMBL:CAI12484.1 xref: EMBL:CAI15438.1 xref: EMBL:CAI21535.1 xref: UniProtKB:Q05513 xref: UniProtKB:Q15207 xref: UniProtKB:Q5SYT5 xref: UniProtKB:Q969S4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004959 ! PRKCZ_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005940 ! pard6a-prkcz physical interaction relationship: participates_in CCO:I0005989 ! pard6a-prkcz-1 physical interaction relationship: participates_in CCO:I0005991 ! pard6b-prkcz-1 physical interaction relationship: participates_in CCO:I0006831 ! prkcz-pard6b-1 physical interaction relationship: participates_in CCO:I0007062 ! pard6b-prkci-2 physical interaction relationship: transforms_into CCO:B0012634 ! KPCZ_HUMAN-Phosphoserine223 relationship: transforms_into CCO:B0012635 ! KPCZ_HUMAN-Phosphothreonine410 relationship: transforms_into CCO:B0012636 ! KPCZ_HUMAN-Phosphothreonine560 [Term] id: CCO:B0005316 name: NDK3_HUMAN def: "Nucleoside diphosphate kinase 3" [UniProtKB:Q13232] synonym: "DR-nm23" EXACT [UniProtKB:Q13232] synonym: "EC 2.7.4.6" EXACT [UniProtKB:Q13232] synonym: "NDK 3" EXACT [UniProtKB:Q13232] synonym: "NDP kinase 3" EXACT [UniProtKB:Q13232] synonym: "NDPKC" EXACT [UniProtKB:Q13232] synonym: "nm23-H3" EXACT [UniProtKB:Q13232] synonym: "Nucleoside diphosphate kinase C" EXACT [UniProtKB:Q13232] xref: EMBL:AAA85097.1 xref: EMBL:AAH00250.1 xref: EMBL:AAK61291.1 xref: UniProtKB:Q13232 xref: UniProtKB:Q9BWH4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005165 ! NME3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005941 ! nme1-nme3 physical interaction relationship: participates_in CCO:I0008137 ! nme3-nme2 physical interaction [Term] id: CCO:B0005317 name: CBX5_HUMAN def: "Chromobox protein homolog 5" [UniProtKB:P45973] synonym: "Antigen p25" EXACT [UniProtKB:P45973] synonym: "Heterochromatin protein 1 homolog alpha" EXACT [UniProtKB:P45973] synonym: "HP1 alpha" EXACT [UniProtKB:P45973] xref: EMBL:AAA72327.1 xref: EMBL:AAB26994.1 xref: EMBL:AAC50553.1 xref: EMBL:AAH06821.1 xref: UniProtKB:P45973 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004232 ! CBX5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005942 ! cbx5-suv39h1 physical interaction relationship: participates_in CCO:I0006674 ! incenp-cbx5-1 physical interaction relationship: participates_in CCO:I0006930 ! smc2-hp1 colocalization relationship: participates_in CCO:I0007394 ! incenp-cbx5-2 physical interaction relationship: participates_in CCO:I0007395 ! cbx5-incenp-1 physical interaction relationship: participates_in CCO:I0007974 ! suv93h1-cbx-1 physical interaction relationship: transforms_into CCO:B0010967 ! CBX5_HUMAN-Phosphothreonine8 relationship: transforms_into CCO:B0010968 ! CBX5_HUMAN-Phosphoserine11 relationship: transforms_into CCO:B0010969 ! CBX5_HUMAN-Phosphoserine12 relationship: transforms_into CCO:B0010970 ! CBX5_HUMAN-Phosphoserine13 relationship: transforms_into CCO:B0010971 ! CBX5_HUMAN-Phosphoserine14 relationship: transforms_into CCO:B0010972 ! CBX5_HUMAN-Phosphoserine92 relationship: transforms_into CCO:B0010973 ! CBX5_HUMAN-Phosphoserine110 [Term] id: CCO:B0005320 name: BATF_HUMAN def: "Basic leucine zipper transcriptional factor ATF-like" [UniProtKB:Q16520] synonym: "B-ATF" EXACT [UniProtKB:Q16520] synonym: "SF-HT-activated gene 2 protein" EXACT [UniProtKB:Q16520] synonym: "SFA-2" EXACT [UniProtKB:Q16520] xref: EMBL:AAC50314.1 xref: EMBL:AAC78243.1 xref: EMBL:AAD51372.1 xref: EMBL:AAH32294.1 xref: EMBL:BAA07686.1 xref: UniProtKB:Q16520 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004142 ! BATF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005951 ! batf-ddit3 physical interaction [Term] id: CCO:B0005321 name: PIAS2_HUMAN def: "E3 SUMO-protein ligase PIAS2" [UniProtKB:O75928] synonym: "Androgen receptor-interacting protein 3" EXACT [UniProtKB:O75928] synonym: "ARIP3" EXACT [UniProtKB:O75928] synonym: "DAB2-interacting protein" EXACT [UniProtKB:O75928] synonym: "DIP" EXACT [UniProtKB:O75928] synonym: "Miz1" EXACT [UniProtKB:O75928] synonym: "Msx-interacting zinc finger protein" EXACT [UniProtKB:O75928] synonym: "PIAS-NY protein" EXACT [UniProtKB:O75928] synonym: "Protein inhibitor of activated STAT x" EXACT [UniProtKB:O75928] synonym: "Protein inhibitor of activated STAT2" EXACT [UniProtKB:O75928] xref: EMBL:AAC36704.1 xref: EMBL:AAC36705.1 xref: EMBL:AAH15190.1 xref: EMBL:AAK48938.1 xref: UniProtKB:O75927 xref: UniProtKB:O75928 xref: UniProtKB:Q96BT5 xref: UniProtKB:Q96KE3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005311 ! PIAS2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005952 ! pias2-ube2i physical interaction [Term] id: CCO:B0005322 name: SMAD4_HUMAN def: "Mothers against decapentaplegic homolog 4" [UniProtKB:Q13485] synonym: "Deletion target in pancreatic carcinoma 4" EXACT [UniProtKB:Q13485] synonym: "hSMAD4" EXACT [UniProtKB:Q13485] synonym: "Mothers against DPP homolog 4" EXACT [UniProtKB:Q13485] synonym: "SMAD 4" EXACT [UniProtKB:Q13485] xref: EMBL:AAA91041.1 xref: EMBL:AAC03051.1 xref: EMBL:AAH02379.1 xref: UniProtKB:Q13485 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005624 ! SMAD4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005954 ! smad4-ube2i physical interaction [Term] id: CCO:B0005323 name: FANCA_HUMAN def: "Fanconi anemia group A protein" [UniProtKB:O15360] synonym: "Protein FACA" EXACT [UniProtKB:O15360] xref: EMBL:AAC28331.1 xref: EMBL:AAC28751.1 xref: EMBL:AAC33304.1 xref: EMBL:AAC33401.1 xref: EMBL:AAH08979.1 xref: EMBL:AAS99350.1 xref: EMBL:CAA12393.1 xref: EMBL:CAA12394.1 xref: EMBL:CAA67610.1 xref: EMBL:CAB05445.1 xref: UniProtKB:O15360 xref: UniProtKB:O75266 xref: UniProtKB:Q6PL10 xref: UniProtKB:Q92497 xref: UniProtKB:Q96H18 xref: UniProtKB:Q9UEA5 xref: UniProtKB:Q9UEL8 xref: UniProtKB:Q9UEL9 xref: UniProtKB:Q9UPK3 xref: UniProtKB:Q9Y6M2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004608 ! FANCA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005959 ! fanca-fancg physical interaction relationship: participates_in CCO:I0007587 ! fancg-fancf-1 physical interaction relationship: transforms_into CCO:B0011840 ! FANCA_HUMAN-Phosphoserine849 relationship: transforms_into CCO:B0011841 ! FANCA_HUMAN-Phosphoserine850 relationship: transforms_into CCO:B0011842 ! FANCA_HUMAN-Phosphoserine858 relationship: transforms_into CCO:B0011843 ! FANCA_HUMAN-Phosphoserine1449 [Term] id: CCO:B0005324 name: CEBPG_HUMAN def: "CCAAT/enhancer-binding protein gamma" [UniProtKB:P53567] synonym: "C/EBP gamma" EXACT [UniProtKB:P53567] xref: EMBL:AAC50201.1 xref: EMBL:AAH07582.1 xref: EMBL:AAH13128.1 xref: EMBL:AAV38622.1 xref: EMBL:AAV38623.1 xref: UniProtKB:P53567 xref: UniProtKB:Q5U052 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004318 ! CEBPG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005961 ! cebpg-ddit3 physical interaction [Term] id: CCO:B0005327 name: CTNB1_HUMAN def: "Catenin beta-1" [UniProtKB:P35222] synonym: "Beta-catenin" EXACT [UniProtKB:P35222] xref: EMBL:AAG35511.1 xref: EMBL:AAH58926.1 xref: EMBL:AAL89457.1 xref: EMBL:AAR18817.1 xref: EMBL:BAB93475.1 xref: EMBL:CAA61107.1 xref: EMBL:CAA79497.1 xref: UniProtKB:P35222 xref: UniProtKB:Q8NEW9 xref: UniProtKB:Q8NI94 xref: UniProtKB:Q9H391 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004417 ! CTNNB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006540 ! apc-ctbb1-1 physical interaction relationship: participates_in CCO:I0006890 ! cdc73-ctnnb1-4 physical interaction relationship: participates_in CCO:I0006999 ! cdc73-ctnnb1 physical interaction relationship: participates_in CCO:I0007024 ! apc-ctnnb1-3 direct interaction relationship: participates_in CCO:I0007414 ! cdc73-ctnnb1-1 physical interaction relationship: participates_in CCO:I0007415 ! cdc73-ctnnb1-2 physical interaction relationship: participates_in CCO:I0007416 ! cdc73-ctnnb1-5 physical interaction relationship: participates_in CCO:I0007790 ! cdc73-ctnnb1-3 physical interaction relationship: participates_in CCO:I0007791 ! cdc73-ctnnb1-6 physical interaction relationship: participates_in CCO:I0007792 ! cdc73-ctnnb1-7 physical interaction relationship: participates_in CCO:I0007917 ! parafibromin-ctnnb1 physical interaction relationship: participates_in CCO:I0007942 ! apc-ctnnb1-1 physical interaction relationship: participates_in CCO:I0008720 ! btrc-ctnnb1-1 physical interaction relationship: transforms_into CCO:B0011372 ! CTNB1_HUMAN-Phosphoserine23 relationship: transforms_into CCO:B0011373 ! CTNB1_HUMAN-Phosphoserine29 relationship: transforms_into CCO:B0011374 ! CTNB1_HUMAN-Phosphoserine33 relationship: transforms_into CCO:B0011375 ! CTNB1_HUMAN-Phosphoserine37 relationship: transforms_into CCO:B0011376 ! CTNB1_HUMAN-Phosphothreonine41 relationship: transforms_into CCO:B0011377 ! CTNB1_HUMAN-Phosphoserine45 relationship: transforms_into CCO:B0011378 ! CTNB1_HUMAN-Phosphotyrosine86 relationship: transforms_into CCO:B0011379 ! CTNB1_HUMAN-Phosphoserine191 relationship: transforms_into CCO:B0011380 ! CTNB1_HUMAN-Phosphothreonine551 relationship: transforms_into CCO:B0011381 ! CTNB1_HUMAN-Phosphoserine552 relationship: transforms_into CCO:B0011382 ! CTNB1_HUMAN-Phosphothreonine556 relationship: transforms_into CCO:B0011383 ! CTNB1_HUMAN-Phosphotyrosine654 relationship: transforms_into CCO:B0011384 ! CTNB1_HUMAN-Phosphoserine675 [Term] id: CCO:B0005328 name: NOGG_HUMAN def: "Noggin precursor" [UniProtKB:Q13253] xref: EMBL:AAA83259.1 xref: EMBL:AAH34027.1 xref: UniProtKB:Q13253 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005203 ! NOG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005973 ! bmp7-nog-1 direct interaction [Term] id: CCO:B0005329 name: UBC12_HUMAN def: "NEDD8-conjugating enzyme Ubc12" [UniProtKB:P61081] synonym: "EC 6.3.2.-" EXACT [UniProtKB:P61081] synonym: "NEDD8 carrier protein" EXACT [UniProtKB:P61081] synonym: "NEDD8 protein ligase" EXACT [UniProtKB:P61081] synonym: "Ubiquitin-conjugating enzyme E2 M" EXACT [UniProtKB:P61081] xref: EMBL:AAC26141.1 xref: EMBL:AAH58924.1 xref: EMBL:AAP35400.1 xref: EMBL:BAA33145.1 xref: UniProtKB:O76069 xref: UniProtKB:P61081 xref: UniProtKB:Q8VC50 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005857 ! UBE2M_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005974 ! ube1c-ube2m-1 direct interaction relationship: participates_in CCO:I0005976 ! nedd8-tp53-1 neddylation [Term] id: CCO:B0005331 name: NEDD8_HUMAN def: "NEDD8 precursor" [UniProtKB:Q15843] synonym: "Neddylin" EXACT [UniProtKB:Q15843] synonym: "Ubiquitin-like protein Nedd8" EXACT [UniProtKB:Q15843] xref: EMBL:AAI04201.1 xref: EMBL:AAI04202.1 xref: EMBL:AAI04665.1 xref: EMBL:BAA04889.1 xref: EMBL:CAG28590.1 xref: UniProtKB:Q15843 xref: UniProtKB:Q3SXN8 xref: UniProtKB:Q6LES6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005173 ! NEDD8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005976 ! nedd8-tp53-1 neddylation relationship: participates_in CCO:I0007022 ! appbp1-nedd8-1 physical interaction relationship: participates_in CCO:I0007023 ! appbp1-nedd8-2 physical interaction [Term] id: CCO:B0005332 name: FBX11_HUMAN def: "F-box only protein 11" [UniProtKB:Q86XK2] synonym: "VIT-1" EXACT [UniProtKB:Q86XK2] synonym: "Vitiligo-associated protein 1" EXACT [UniProtKB:Q86XK2] xref: EMBL:AAF04520.1 xref: EMBL:AAF17611.1 xref: EMBL:AAF76888.1 xref: EMBL:AAH12728.2 xref: EMBL:AAH43258.2 xref: EMBL:AAN76518.1 xref: EMBL:AAV87312.1 xref: EMBL:BAB14214.1 xref: EMBL:BAB15143.1 xref: EMBL:BAD97312.1 xref: EMBL:CAB56019.1 xref: UniProtKB:Q52ZP1 xref: UniProtKB:Q53EP7 xref: UniProtKB:Q86XK2 xref: UniProtKB:Q8IXG3 xref: UniProtKB:Q96E90 xref: UniProtKB:Q9H6V8 xref: UniProtKB:Q9H9L1 xref: UniProtKB:Q9NR14 xref: UniProtKB:Q9UFK1 xref: UniProtKB:Q9UHI1 xref: UniProtKB:Q9UKC2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004621 ! FBXO11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005976 ! nedd8-tp53-1 neddylation relationship: participates_in CCO:I0006246 ! tp53-fbxo11-3 physical interaction relationship: participates_in CCO:I0006780 ! tp53-fbxo11-2 direct interaction relationship: participates_in CCO:I0007835 ! tp53-fbxo11-1 physical interaction relationship: participates_in CCO:I0007943 ! fbxo11-skp1-1 physical interaction [Term] id: CCO:B0005333 name: HSPB9_HUMAN def: "Heat shock protein beta-9" [UniProtKB:Q9BQS6] synonym: "Cancer/testis antigen 51" EXACT [UniProtKB:Q9BQS6] synonym: "CT51" EXACT [UniProtKB:Q9BQS6] synonym: "HspB9" EXACT [UniProtKB:Q9BQS6] xref: EMBL:AAH93991.1 xref: EMBL:AAH93993.1 xref: EMBL:CAC35727.1 xref: UniProtKB:Q52LB4 xref: UniProtKB:Q9BQS6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004841 ! HSPB9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005977 ! hspb9-ctcf physical interaction [Term] id: CCO:B0005334 name: UBE3A_HUMAN def: "Ubiquitin-protein ligase E3A" [UniProtKB:Q05086] synonym: "E6AP ubiquitin-protein ligase" EXACT [UniProtKB:Q05086] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q05086] synonym: "Human papillomavirus E6-associated protein" EXACT [UniProtKB:Q05086] synonym: "Oncogenic protein-associated protein E6-AP" EXACT [UniProtKB:Q05086] synonym: "Renal carcinoma antigen NY-REN-54" EXACT [UniProtKB:Q05086] xref: EMBL:AAA35542.1 xref: EMBL:AAB49301.1 xref: EMBL:AAB69154.1 xref: EMBL:CAA04534.1 xref: EMBL:CAA04535.1 xref: EMBL:CAA04536.1 xref: EMBL:CAA04537.1 xref: EMBL:CAA04538.1 xref: EMBL:CAA04539.1 xref: EMBL:CAA66653.1 xref: EMBL:CAA66654.1 xref: EMBL:CAA66655.1 xref: EMBL:CAA66656.1 xref: UniProtKB:P78355 xref: UniProtKB:Q05086 xref: UniProtKB:Q93066 xref: UniProtKB:Q9UEP4 xref: UniProtKB:Q9UEP5 xref: UniProtKB:Q9UEP6 xref: UniProtKB:Q9UEP7 xref: UniProtKB:Q9UEP8 xref: UniProtKB:Q9UEP9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005862 ! UBE3A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005978 ! e6-e6ap-tp53 physical interaction relationship: participates_in CCO:I0005979 ! e6ap-tp53 physical interaction relationship: transforms_into CCO:B0014564 ! UBE3A_HUMAN-Phosphoserine218 [Term] id: CCO:B0005335 name: SNIP1_HUMAN def: "Smad nuclear-interacting protein 1" [UniProtKB:Q8TAD8] xref: EMBL:AAH27040.1 xref: EMBL:AAL91140.1 xref: EMBL:BAB14134.1 xref: EMBL:BAB55241.1 xref: UniProtKB:Q8TAD8 xref: UniProtKB:Q96SP9 xref: UniProtKB:Q9H9T7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005645 ! SNIP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005980 ! snip1-myc-2 physical interaction relationship: participates_in CCO:I0005981 ! myc-snip1-1 physical interaction relationship: participates_in CCO:I0005983 ! snip1-myc-4 physical interaction relationship: participates_in CCO:I0006463 ! snip1-myc-1 physical interaction relationship: participates_in CCO:I0006607 ! snip1-myc physical interaction relationship: participates_in CCO:I0006784 ! myc-snip1 physical interaction relationship: participates_in CCO:I0006934 ! snip1-myc-3 physical interaction relationship: participates_in CCO:I0006935 ! myc-snip1-2 physical interaction relationship: participates_in CCO:I0007187 ! myc-snip1-3 physical interaction relationship: transforms_into CCO:B0014137 ! SNIP1_HUMAN-Phosphoserine35 relationship: transforms_into CCO:B0014138 ! SNIP1_HUMAN-Phosphoserine89 relationship: transforms_into CCO:B0014139 ! SNIP1_HUMAN-Phosphoserine91 relationship: transforms_into CCO:B0014140 ! SNIP1_HUMAN-Phosphoserine153 relationship: transforms_into CCO:B0014141 ! SNIP1_HUMAN-Phosphothreonine169 relationship: transforms_into CCO:B0014142 ! SNIP1_HUMAN-Phosphoserine202 relationship: transforms_into CCO:B0014143 ! SNIP1_HUMAN-Phosphoserine394 [Term] id: CCO:B0005336 name: MAX_HUMAN def: "Protein max" [UniProtKB:P61244] synonym: "Myc-associated factor X" EXACT [UniProtKB:P61244] xref: EMBL:AAA36200.1 xref: EMBL:AAA36201.1 xref: EMBL:AAH03525.1 xref: EMBL:AAH04516.1 xref: EMBL:AAH27924.1 xref: EMBL:CAA42827.1 xref: EMBL:CAA47337.1 xref: EMBL:CAA47338.1 xref: UniProtKB:P25912 xref: UniProtKB:P52163 xref: UniProtKB:P61244 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005033 ! MAX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005982 ! max-myc-4 physical interaction relationship: participates_in CCO:I0007007 ! myc-max physical interaction relationship: transforms_into CCO:B0012794 ! MAX_HUMAN-Phosphoserine2 relationship: transforms_into CCO:B0012795 ! MAX_HUMAN-Phosphoserine11 relationship: transforms_into CCO:B0012796 ! MAX_HUMAN-N6-acetyllysine66 relationship: transforms_into CCO:B0012797 ! MAX_HUMAN-Phosphotyrosine123 relationship: transforms_into CCO:B0012798 ! MAX_HUMAN-N6-acetyllysine153 relationship: transforms_into CCO:B0012799 ! MAX_HUMAN-N6-acetyllysine154 [Term] id: CCO:B0005337 name: RAC1_HUMAN def: "Ras-related C3 botulinum toxin substrate 1 precursor" [UniProtKB:P63000] synonym: "Cell migration-inducing gene 5 protein" EXACT [UniProtKB:P63000] synonym: "p21-Rac1" EXACT [UniProtKB:P63000] synonym: "Ras-like protein TC25" EXACT [UniProtKB:P63000] xref: EMBL:AAA36537.1 xref: EMBL:AAA36544.1 xref: EMBL:AAD30547.1 xref: EMBL:AAH04247.1 xref: EMBL:AAH50687.1 xref: EMBL:AAI07749.1 xref: EMBL:AAM21111.1 xref: EMBL:AAP35785.1 xref: EMBL:AAQ16632.1 xref: EMBL:AAS07511.1 xref: EMBL:AAS07512.1 xref: EMBL:AAZ80485.1 xref: EMBL:CAA10732.1 xref: EMBL:CAA10733.6 xref: EMBL:CAB53579.5 xref: UniProtKB:O95501 xref: UniProtKB:P15154 xref: UniProtKB:P63000 xref: UniProtKB:Q3Y4D3 xref: UniProtKB:Q5JAA8 xref: UniProtKB:Q9BTB4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005411 ! RAC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005993 ! pard6a-rac1-2 physical interaction relationship: participates_in CCO:I0005995 ! pard6b-rac1-1 physical interaction relationship: participates_in CCO:I0005997 ! pard6g-rac1-1 physical interaction relationship: participates_in CCO:I0006835 ! rac1-pard6a-1 physical interaction relationship: participates_in CCO:I0006836 ! rac1-pard6b-1 physical interaction relationship: participates_in CCO:I0006837 ! rac1-pard6g-1 physical interaction relationship: participates_in CCO:I0007063 ! rac1-pard6b-2 physical interaction relationship: transforms_into CCO:B0013659 ! RAC1_HUMAN-ADP-ribosylasparagine39 relationship: transforms_into CCO:B0013660 ! RAC1_HUMAN-Cysteine methyl ester189 [Term] id: CCO:B0005338 name: CDC42_HUMAN def: "Cell division control protein 42 homolog precursor" [UniProtKB:P60953] synonym: "G25K GTP-binding protein" EXACT [UniProtKB:P60953] xref: EMBL:AAA52494.1 xref: EMBL:AAA52592.1 xref: EMBL:AAH02711.1 xref: EMBL:AAH03682.1 xref: EMBL:AAH18266.1 xref: EMBL:AAM21109.1 xref: EMBL:AAM21110.1 xref: EMBL:AAT70721.1 xref: EMBL:CAB52602.1 xref: EMBL:CAB57325.1 xref: EMBL:CAB57326.1 xref: EMBL:CAD92551.1 xref: UniProtKB:P21181 xref: UniProtKB:P25763 xref: UniProtKB:P60953 xref: UniProtKB:Q7L8R5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004290 ! CDC42_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005994 ! pard6a-cdc42-4 physical interaction relationship: participates_in CCO:I0005996 ! pard6b-cdc42-4 physical interaction relationship: participates_in CCO:I0005998 ! pard6g-cdc42-1 physical interaction relationship: participates_in CCO:I0006632 ! pard6a-cdc42-2 physical interaction relationship: participates_in CCO:I0006634 ! pard6a-cdc42-3 physical interaction relationship: participates_in CCO:I0006832 ! cdc42-pard6a-1 physical interaction relationship: participates_in CCO:I0006833 ! cdc42-pard6b-1 physical interaction relationship: participates_in CCO:I0006834 ! cdc42-pard6g-1 physical interaction relationship: participates_in CCO:I0007064 ! cdc42-pard6b-2 physical interaction relationship: participates_in CCO:I0007205 ! pard6a-cdc42-5 physical interaction relationship: participates_in CCO:I0007224 ! cdc42-pard6a-2 physical interaction relationship: participates_in CCO:I0007225 ! pard6b-cdc42-6 physical interaction relationship: participates_in CCO:I0007226 ! cdc42-pard6b-3 physical interaction relationship: participates_in CCO:I0008002 ! cdc42-rif1 physical interaction relationship: participates_in CCO:I0008003 ! cdc42-tp53 physical interaction relationship: transforms_into CCO:B0011083 ! CDC42_HUMAN-Cysteine methyl ester188 [Term] id: CCO:B0005339 name: CBP_HUMAN def: "CREB-binding protein" [UniProtKB:Q92793] synonym: "EC 2.3.1.48" EXACT [UniProtKB:Q92793] xref: EMBL:AAC51331.2 xref: EMBL:AAC51339.1 xref: EMBL:AAC51340.1 xref: EMBL:AAC51770.1 xref: UniProtKB:O00147 xref: UniProtKB:Q16376 xref: UniProtKB:Q92793 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004230 ! CREBBP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006713 ! crebbp-khdrbs1-9 colocalization relationship: participates_in CCO:I0006857 ! p53-crebbp-6 physical interaction relationship: participates_in CCO:I0007083 ! p53-crebbp-2 physical interaction relationship: participates_in CCO:I0007084 ! p53-crebbp-3 physical interaction relationship: participates_in CCO:I0007085 ! p53-crebbp-4 physical interaction relationship: participates_in CCO:I0007086 ! p53-crebbp-5 physical interaction relationship: participates_in CCO:I0007242 ! p53-crebbp-1 physical interaction relationship: transforms_into CCO:B0010953 ! CBP_HUMAN-Phosphoserine124 relationship: transforms_into CCO:B0010954 ! CBP_HUMAN-Omega-N-methylated arginine601 relationship: transforms_into CCO:B0010955 ! CBP_HUMAN-Omega-N-methylated arginine625 relationship: transforms_into CCO:B0010956 ! CBP_HUMAN-Phosphothreonine1001 relationship: transforms_into CCO:B0010957 ! CBP_HUMAN-Phosphoserine1030 relationship: transforms_into CCO:B0010958 ! CBP_HUMAN-Phosphoserine1072 relationship: transforms_into CCO:B0010959 ! CBP_HUMAN-N6-acetyllysine1588 relationship: transforms_into CCO:B0010960 ! CBP_HUMAN-N6-acetyllysine1591 relationship: transforms_into CCO:B0010961 ! CBP_HUMAN-N6-acetyllysine1592 relationship: transforms_into CCO:B0010962 ! CBP_HUMAN-N6-acetyllysine1595 relationship: transforms_into CCO:B0010963 ! CBP_HUMAN-N6-acetyllysine1597 relationship: transforms_into CCO:B0010964 ! CBP_HUMAN-Phosphoserine1755 [Term] id: CCO:B0005343 name: HDAC2_HUMAN def: "Histone deacetylase 2" [UniProtKB:Q92769] synonym: "EC 3.5.1.98" EXACT [UniProtKB:Q92769] synonym: "HD2" EXACT [UniProtKB:Q92769] xref: EMBL:AAC50814.1 xref: EMBL:AAH31055.2 xref: EMBL:CAI14206.1 xref: EMBL:CAI14207.1 xref: EMBL:CAI15363.1 xref: UniProtKB:Q5SRI8 xref: UniProtKB:Q5SZ86 xref: UniProtKB:Q8NEH4 xref: UniProtKB:Q92769 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004787 ! HDAC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006303 ! hcfc1-hdac2-1 physical interaction relationship: participates_in CCO:I0006822 ! brms1-hdac2 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: participates_in CCO:I0007190 ! hdac2-brms1 physical interaction relationship: participates_in CCO:I0007459 ! suv39h1-hdac2-3 physical interaction relationship: participates_in CCO:I0007916 ! pa2g4-hdac2-1 physical interaction relationship: participates_in CCO:I0007977 ! suv93h1-hdac2-1 physical interaction relationship: participates_in CCO:I0007978 ! suv93h1-hdac2-2 physical interaction relationship: transforms_into CCO:B0012159 ! HDAC2_HUMAN-Phosphoserine394 relationship: transforms_into CCO:B0012160 ! HDAC2_HUMAN-Phosphoserine407 relationship: transforms_into CCO:B0012161 ! HDAC2_HUMAN-Phosphoserine422 relationship: transforms_into CCO:B0012162 ! HDAC2_HUMAN-Phosphoserine424 [Term] id: CCO:B0005344 name: MARK4_HUMAN def: "MAP/microtubule affinity-regulating kinase 4" [UniProtKB:Q96L34] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q96L34] synonym: "MAP/microtubule affinity-regulating kinase-like 1" EXACT [UniProtKB:Q96L34] xref: EMBL:AAL23683.1 xref: EMBL:AAM55491.1 xref: EMBL:BAB39380.1 xref: EMBL:BAB47489.1 xref: EMBL:BAB55238.1 xref: EMBL:BAC03375.1 xref: EMBL:BAC11510.1 xref: UniProtKB:Q8NG37 xref: UniProtKB:Q96JG7 xref: UniProtKB:Q96L34 xref: UniProtKB:Q96SQ2 xref: UniProtKB:Q9BYD8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005028 ! MARK4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006006 ! tubg-mark4-2 physical interaction relationship: participates_in CCO:I0006007 ! tubg-mark4-3 physical interaction relationship: participates_in CCO:I0007067 ! tubg-mark4-1 physical interaction relationship: participates_in CCO:I0007210 ! pard6a-mark4-1 physical interaction relationship: participates_in CCO:I0007217 ! stk11-mark4-1 physical interaction relationship: transforms_into CCO:B0012776 ! MARK4_HUMAN-Phosphoserine26 relationship: transforms_into CCO:B0012777 ! MARK4_HUMAN-Phosphothreonine214 [Term] id: CCO:B0005345 name: XPA_HUMAN def: "DNA-repair protein complementing XP-A cells" [UniProtKB:P23025] synonym: "Xeroderma pigmentosum group A-complementing protein" EXACT [UniProtKB:P23025] xref: EMBL:AAB60404.1 xref: EMBL:AAH14965.1 xref: EMBL:AAM18969.1 xref: EMBL:AAV38325.1 xref: EMBL:BAA03403.1 xref: UniProtKB:P23025 xref: UniProtKB:Q6LCW7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005938 ! XPA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006011 ! rassf1-xpa physical interaction relationship: transforms_into CCO:B0014707 ! XPA_HUMAN-Phosphoserine196 [Term] id: CCO:B0005346 name: SK2L2_HUMAN def: "Superkiller viralicidic activity 2-like 2" [UniProtKB:P42285] synonym: "ATP-dependent helicase SKIV2L2" EXACT [UniProtKB:P42285] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P42285] xref: EMBL:AAH14669.2 xref: EMBL:AAH28604.3 xref: EMBL:AAH31779.1 xref: EMBL:AAH65258.1 xref: EMBL:AAI04997.1 xref: EMBL:AAI13510.1 xref: EMBL:BAA06124.2 xref: EMBL:CAE45877.1 xref: UniProtKB:P42285 xref: UniProtKB:Q2M386 xref: UniProtKB:Q6MZZ8 xref: UniProtKB:Q6P170 xref: UniProtKB:Q8N5R0 xref: UniProtKB:Q8TAG2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005618 ! SKIV2L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006012 ! mphosph6-kiaa0052 physical interaction [Term] id: CCO:B0005347 name: PARN_HUMAN def: "Poly(A)-specific ribonuclease PARN" [UniProtKB:O95453] synonym: "Deadenylating nuclease" EXACT [UniProtKB:O95453] synonym: "Deadenylation nuclease" EXACT [UniProtKB:O95453] synonym: "EC 3.1.13.4" EXACT [UniProtKB:O95453] synonym: "Polyadenylate-specific ribonuclease" EXACT [UniProtKB:O95453] xref: EMBL:AAH50029.1 xref: EMBL:CAA06683.1 xref: UniProtKB:O95453 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005268 ! PARN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006013 ! mphosph6-parn physical interaction relationship: transforms_into CCO:B0013398 ! PARN_HUMAN-Phosphoserine163 relationship: transforms_into CCO:B0013399 ! PARN_HUMAN-Phosphoserine557 relationship: transforms_into CCO:B0013400 ! PARN_HUMAN-Phosphoserine587 relationship: transforms_into CCO:B0013401 ! PARN_HUMAN-Phosphoserine619 [Term] id: CCO:B0005348 name: EXOSX_HUMAN def: "Exosome component 10" [UniProtKB:Q01780] synonym: "Autoantigen PM/Scl 2" EXACT [UniProtKB:Q01780] synonym: "P100 polymyositis-scleroderma overlap syndrome-associated autoantigen" EXACT [UniProtKB:Q01780] synonym: "PM/Scl-100" EXACT [UniProtKB:Q01780] synonym: "Polymyositis/scleroderma autoantigen 100 kDa" EXACT [UniProtKB:Q01780] synonym: "Polymyositis/scleroderma autoantigen 2" EXACT [UniProtKB:Q01780] xref: EMBL:AAB59352.1 xref: EMBL:AAH39901.1 xref: EMBL:AAH73788.1 xref: EMBL:CAA46904.1 xref: EMBL:CAC15569.1 xref: UniProtKB:Q01780 xref: UniProtKB:Q15158 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004601 ! EXOSC10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006014 ! mphosph6-pmscl2 physical interaction [Term] id: CCO:B0005349 name: LSM8_HUMAN def: "U6 snRNA-associated Sm-like protein LSm8" [UniProtKB:O95777] xref: EMBL:AAD15542.1 xref: EMBL:AAD56232.1 xref: EMBL:AAH02742.1 xref: EMBL:AAH22440.1 xref: UniProtKB:O95777 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004995 ! LSM8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006015 ! lsm8-rent1 physical interaction relationship: participates_in CCO:I0006497 ! lsm8-ask/h37_(hudbf4 physical interaction relationship: participates_in CCO:I0006498 ! lsm8-sept5 physical interaction relationship: transforms_into CCO:B0012708 ! LSM8_HUMAN-N-acetylthreonine2 [Term] id: CCO:B0005350 name: TRRAP_HUMAN def: "Transformation/transcription domain-associated protein" [UniProtKB:Q9Y4A5] synonym: "350/400 kDa PCAF-associated factor" EXACT [UniProtKB:Q9Y4A5] synonym: "PAF350/400" EXACT [UniProtKB:Q9Y4A5] synonym: "STAF40" EXACT [UniProtKB:Q9Y4A5] synonym: "Tra1 homolog" EXACT [UniProtKB:Q9Y4A5] xref: EMBL:AAC27675.2 xref: EMBL:AAC62433.1 xref: EMBL:AAD04629.1 xref: EMBL:AAD09420.1 xref: UniProtKB:O75218 xref: UniProtKB:Q9Y4A5 xref: UniProtKB:Q9Y631 xref: UniProtKB:Q9Y6H4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005837 ! TRRAP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006017 ! e2f1-trrap-1 physical interaction relationship: participates_in CCO:I0006018 ! e2f4-trrap-1 physical interaction relationship: participates_in CCO:I0006703 ! trrap-myc-2 physical interaction relationship: participates_in CCO:I0006748 ! brca1-trrap-2 physical interaction relationship: participates_in CCO:I0006887 ! brca1-trrap-6 physical interaction relationship: participates_in CCO:I0007076 ! trrap-myc-1 physical interaction relationship: participates_in CCO:I0007367 ! trrap-brca1 direct interaction relationship: participates_in CCO:I0007410 ! c20orf20-epc1-4 physical interaction relationship: participates_in CCO:I0007454 ! brca1-trrap physical interaction relationship: participates_in CCO:I0007455 ! brca1-trrap-1 physical interaction relationship: participates_in CCO:I0007594 ! brca1-trrap-4 direct interaction relationship: participates_in CCO:I0007595 ! brca1-trrap-5 physical interaction relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction relationship: transforms_into CCO:B0014538 ! TRRAP_HUMAN-Phosphoserine2051 relationship: transforms_into CCO:B0014539 ! TRRAP_HUMAN-Phosphoserine2077 [Term] id: CCO:B0005351 name: TIP60_HUMAN def: "Histone acetyltransferase HTATIP" [UniProtKB:Q92993] synonym: "60 kDa Tat interactive protein" EXACT [UniProtKB:Q92993] synonym: "cPLA(2)-interacting protein" EXACT [UniProtKB:Q92993] synonym: "EC 2.3.1.-" EXACT [UniProtKB:Q92993] synonym: "EC 2.3.1.48" EXACT [UniProtKB:Q92993] synonym: "HIV-1 Tat interactive protein" EXACT [UniProtKB:Q92993] synonym: "Tip60" EXACT [UniProtKB:Q92993] xref: EMBL:AAB02683.1 xref: EMBL:AAB18236.1 xref: EMBL:AAD00163.1 xref: EMBL:AAH00166.3 xref: EMBL:AAH64912.1 xref: EMBL:AAI17168.1 xref: EMBL:AAO21130.1 xref: UniProtKB:O95624 xref: UniProtKB:Q13430 xref: UniProtKB:Q17RW5 xref: UniProtKB:Q6GSE8 xref: UniProtKB:Q92993 xref: UniProtKB:Q9BWK7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005784 ! HTATIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006019 ! htatip-trrap-1 physical interaction relationship: participates_in CCO:I0006166 ! bard1-htatip physical interaction relationship: participates_in CCO:I0007576 ! htatip-dleu1-1 physical interaction relationship: participates_in CCO:I0008094 ! dleu1-htatip physical interaction relationship: participates_in CCO:I0008131 ! mad2l1bp-htatip physical interaction relationship: transforms_into CCO:B0014378 ! TIP60_HUMAN-Phosphoserine86 relationship: transforms_into CCO:B0014379 ! TIP60_HUMAN-Phosphoserine90 [Term] id: CCO:B0005352 name: ORC1_HUMAN def: "Origin recognition complex subunit 1" [UniProtKB:Q13415] synonym: "Replication control protein 1" EXACT [UniProtKB:Q13415] xref: EMBL:AAA86260.1 xref: EMBL:AAC50325.1 xref: EMBL:CAI12288.1 xref: UniProtKB:Q13415 xref: UniProtKB:Q13471 xref: UniProtKB:Q5T0F5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005232 ! ORC1L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006020 ! orc1-cdk2-1 physical interaction relationship: participates_in CCO:I0006075 ! orc1l-hscdc6 direct interaction relationship: participates_in CCO:I0006076 ! orc1l-hscdc5 direct interaction relationship: participates_in CCO:I0006197 ! orc1-skp2-2 physical interaction relationship: participates_in CCO:I0007537 ! orc1-skp2-1 physical interaction relationship: transforms_into CCO:B0013330 ! ORC1_HUMAN-Phosphoserine417 relationship: transforms_into CCO:B0013331 ! ORC1_HUMAN-Phosphoserine419 relationship: transforms_into CCO:B0013332 ! ORC1_HUMAN-Phosphoserine420 relationship: transforms_into CCO:B0013333 ! ORC1_HUMAN-Phosphoserine421 [Term] id: CCO:B0005353 name: ORC2_HUMAN def: "Origin recognition complex subunit 2" [UniProtKB:Q13416] xref: EMBL:AAB33970.1 xref: EMBL:AAC50326.2 xref: EMBL:AAH14834.1 xref: EMBL:AAT46690.1 xref: UniProtKB:Q13204 xref: UniProtKB:Q13416 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005233 ! ORC2L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006021 ! orc1-orc2-1 physical interaction relationship: participates_in CCO:I0006084 ! mcm2-orc2l direct interaction relationship: participates_in CCO:I0006097 ! orc2l-hscdc5 direct interaction relationship: participates_in CCO:I0006100 ! orc2l-hscdc6 direct interaction relationship: participates_in CCO:I0006150 ! orc2l-cdk2 direct interaction relationship: participates_in CCO:I0007539 ! orc2-mcm3-1 physical interaction relationship: participates_in CCO:I0007540 ! mcm3-mcm5-1 physical interaction [Term] id: CCO:B0005354 name: T2FA_HUMAN def: "General transcription factor IIF subunit 1" [UniProtKB:P35269] synonym: "General transcription factor IIF polypeptide 1 74 kDa subunit protein" EXACT [UniProtKB:P35269] synonym: "TFIIF-alpha" EXACT [UniProtKB:P35269] synonym: "Transcription initiation factor IIF subunit alpha" EXACT [UniProtKB:P35269] synonym: "Transcription initiation factor RAP74" EXACT [UniProtKB:P35269] xref: EMBL:AAH00120.1 xref: EMBL:AAH13007.1 xref: EMBL:AAP35761.1 xref: EMBL:CAA45404.1 xref: EMBL:CAA45408.1 xref: UniProtKB:P35269 xref: UniProtKB:Q9BWN0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005716 ! GTF2F1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006023 ! taf1-gtf2f1-3 physical interaction relationship: participates_in CCO:I0006199 ! taf1-gtf2f1-1 physical interaction relationship: participates_in CCO:I0006200 ! taf1-gtf2f1-2 physical interaction relationship: transforms_into CCO:B0014275 ! T2FA_HUMAN-Phosphoserine217 relationship: transforms_into CCO:B0014276 ! T2FA_HUMAN-Phosphoserine218 relationship: transforms_into CCO:B0014277 ! T2FA_HUMAN-Phosphoserine221 relationship: transforms_into CCO:B0014278 ! T2FA_HUMAN-Phosphoserine224 relationship: transforms_into CCO:B0014279 ! T2FA_HUMAN-Phosphoserine305 relationship: transforms_into CCO:B0014280 ! T2FA_HUMAN-Phosphoserine307 relationship: transforms_into CCO:B0014281 ! T2FA_HUMAN-Phosphoserine308 relationship: transforms_into CCO:B0014282 ! T2FA_HUMAN-Phosphoserine311 relationship: transforms_into CCO:B0014283 ! T2FA_HUMAN-Phosphoserine342 relationship: transforms_into CCO:B0014284 ! T2FA_HUMAN-Phosphoserine345 relationship: transforms_into CCO:B0014285 ! T2FA_HUMAN-Phosphoserine347 relationship: transforms_into CCO:B0014286 ! T2FA_HUMAN-Phosphoserine348 relationship: transforms_into CCO:B0014287 ! T2FA_HUMAN-Phosphoserine351 relationship: transforms_into CCO:B0014288 ! T2FA_HUMAN-Phosphoserine355 relationship: transforms_into CCO:B0014289 ! T2FA_HUMAN-Phosphoserine385 relationship: transforms_into CCO:B0014290 ! T2FA_HUMAN-Phosphothreonine389 relationship: transforms_into CCO:B0014291 ! T2FA_HUMAN-Phosphoserine433 [Term] id: CCO:B0005355 name: CAND1_HUMAN def: "Cullin-associated NEDD8-dissociated protein 1" [UniProtKB:Q86VP6] synonym: "Cullin-associated and neddylation-dissociated protein 1" EXACT [UniProtKB:Q86VP6] synonym: "p120 CAND1" EXACT [UniProtKB:Q86VP6] synonym: "TBP-interacting protein of 120 kDa A" EXACT [UniProtKB:Q86VP6] synonym: "TBP-interacting protein TIP120A" EXACT [UniProtKB:Q86VP6] xref: EMBL:AAF67492.1 xref: EMBL:AAH04232.1 xref: EMBL:AAH26220.1 xref: EMBL:AAH50341.1 xref: EMBL:BAA74852.2 xref: EMBL:BAB55090.1 xref: EMBL:BAB55365.1 xref: EMBL:CAB63714.1 xref: EMBL:CAB66744.1 xref: EMBL:CAD38737.1 xref: UniProtKB:O94918 xref: UniProtKB:Q6PIY4 xref: UniProtKB:Q86VP6 xref: UniProtKB:Q8NDJ4 xref: UniProtKB:Q96JZ9 xref: UniProtKB:Q96T19 xref: UniProtKB:Q9BTC4 xref: UniProtKB:Q9H0G2 xref: UniProtKB:Q9P0H7 xref: UniProtKB:Q9UF85 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004218 ! CAND1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006024 ! cul1-cand1 physical interaction relationship: participates_in CCO:I0006308 ! cul1-cand1-4 physical interaction relationship: participates_in CCO:I0006309 ! cul1-cand1-5 physical interaction relationship: participates_in CCO:I0006310 ! cul1-cand1-6 physical interaction relationship: participates_in CCO:I0006682 ! cul4b-tip120a-1 physical interaction relationship: participates_in CCO:I0006683 ! cul4a-tip120a-1 physical interaction relationship: participates_in CCO:I0006684 ! cul3-tip120a-2 physical interaction relationship: participates_in CCO:I0006685 ! cul1-tip120a-1 physical interaction relationship: participates_in CCO:I0006686 ! cul2-tip120a-2 physical interaction relationship: participates_in CCO:I0006687 ! cul4b-tip120a-2 physical interaction relationship: participates_in CCO:I0006688 ! cul1-tip120a-2 physical interaction relationship: participates_in CCO:I0006689 ! cul2-tip120a-1 physical interaction relationship: participates_in CCO:I0006690 ! cul3-tip120a-1 physical interaction relationship: participates_in CCO:I0006691 ! cul4a-tip120a-2 physical interaction relationship: participates_in CCO:I0006692 ! cul4b-tip120a-3 physical interaction relationship: participates_in CCO:I0006693 ! cul1-tip120a-3 physical interaction relationship: participates_in CCO:I0006694 ! cul1-tip120a-4 physical interaction relationship: participates_in CCO:I0006865 ! cand1-cul1-3 physical interaction relationship: participates_in CCO:I0006866 ! cul1-cand1-7 physical interaction relationship: participates_in CCO:I0007103 ! cul2-cand1 physical interaction relationship: participates_in CCO:I0007104 ! cul4a-cand1 physical interaction relationship: participates_in CCO:I0007106 ! cul1-cand1-1 physical interaction relationship: participates_in CCO:I0007107 ! cand1-cul1 physical interaction relationship: participates_in CCO:I0007108 ! cand1-cul1-1 physical interaction relationship: participates_in CCO:I0007109 ! cul1-cand1-2 physical interaction relationship: participates_in CCO:I0007113 ! cand1-cul1-4 physical interaction relationship: participates_in CCO:I0007114 ! cul1-cand1-8 physical interaction relationship: participates_in CCO:I0007254 ! cand1-cul1-2 physical interaction relationship: participates_in CCO:I0007504 ! cand1-cul1-5 physical interaction relationship: transforms_into CCO:B0035989 ! CAND1_HUMAN-Phosphothreonine624 [Term] id: CCO:B0005356 name: ANDR_HUMAN def: "Androgen receptor" [UniProtKB:P10275] synonym: "Dihydrotestosterone receptor" EXACT [UniProtKB:P10275] synonym: "Nuclear receptor subfamily 3 group C member 4" EXACT [UniProtKB:P10275] xref: EMBL:AAA51729.1 xref: EMBL:AAA51770.1 xref: EMBL:AAA51771.1 xref: EMBL:AAA51772.1 xref: EMBL:AAA51774.1 xref: EMBL:AAA51775.1 xref: EMBL:AAA51780.1 xref: EMBL:AAA51886.1 xref: EMBL:AAB21256.2 xref: EMBL:AAB21257.2 xref: EMBL:AAB60346.1 xref: UniProtKB:P10275 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004058 ! AR_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007144 ! pa2g4-ar-1 physical interaction relationship: transforms_into CCO:B0026337 ! ANDR_HUMAN-Phosphotyrosine223 relationship: transforms_into CCO:B0026338 ! ANDR_HUMAN-Phosphotyrosine267 relationship: transforms_into CCO:B0026339 ! ANDR_HUMAN-Phosphotyrosine307 relationship: transforms_into CCO:B0026340 ! ANDR_HUMAN-Phosphotyrosine346 relationship: transforms_into CCO:B0026341 ! ANDR_HUMAN-Phosphotyrosine357 relationship: transforms_into CCO:B0026342 ! ANDR_HUMAN-Phosphotyrosine362 relationship: transforms_into CCO:B0026343 ! ANDR_HUMAN-Phosphotyrosine363 relationship: transforms_into CCO:B0026344 ! ANDR_HUMAN-Phosphotyrosine393 relationship: transforms_into CCO:B0026345 ! ANDR_HUMAN-Phosphotyrosine534 relationship: transforms_into CCO:B0026346 ! ANDR_HUMAN-Phosphotyrosine551 relationship: transforms_into CCO:B0026347 ! ANDR_HUMAN-Phosphotyrosine915 [Term] id: CCO:B0005357 name: SIN3A_HUMAN def: "Paired amphipathic helix protein Sin3a" [UniProtKB:Q96ST3] synonym: "Histone deacetylase complex subunit Sin3a" EXACT [UniProtKB:Q96ST3] synonym: "Transcriptional corepressor Sin3a" EXACT [UniProtKB:Q96ST3] xref: EMBL:AAH18973.1 xref: EMBL:AAK95854.1 xref: EMBL:AAP97288.1 xref: EMBL:BAB55197.1 xref: EMBL:BAC04801.1 xref: EMBL:BAC11280.1 xref: EMBL:CAB55972.1 xref: UniProtKB:Q8N8N4 xref: UniProtKB:Q8NC83 xref: UniProtKB:Q8WV18 xref: UniProtKB:Q96L98 xref: UniProtKB:Q96ST3 xref: UniProtKB:Q9UFQ1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005614 ! SIN3A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006030 ! hcfc1-many-4 physical interaction relationship: participates_in CCO:I0006612 ! p53-sin3a-2 physical interaction relationship: participates_in CCO:I0006972 ! hcfc1-many-3 physical interaction relationship: participates_in CCO:I0007095 ! hcfc1-sin3a-1 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: participates_in CCO:I0007243 ! p53-sin3a-1 physical interaction relationship: participates_in CCO:I0007251 ! hcfc1-sin3a-2 physical interaction relationship: participates_in CCO:I0007355 ! hcfc1-many-2 physical interaction relationship: participates_in CCO:I0007561 ! hcfc1-sin3a-3 physical interaction relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0014060 ! SIN3A_HUMAN-Phosphoserine832 relationship: transforms_into CCO:B0014061 ! SIN3A_HUMAN-Phosphoserine860 relationship: transforms_into CCO:B0014062 ! SIN3A_HUMAN-Phosphoserine1112 [Term] id: CCO:B0005358 name: WRN_HUMAN def: "Werner syndrome ATP-dependent helicase" [UniProtKB:Q14191] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q14191] xref: EMBL:AAC41981.1 xref: EMBL:AAC63361.1 xref: EMBL:AAF06162.1 xref: EMBL:AAR05448.1 xref: UniProtKB:Q14191 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005933 ! WRN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006032 ! wrn-rad52-9 colocalization relationship: participates_in CCO:I0006033 ! wrn-p53-3 colocalization relationship: participates_in CCO:I0006212 ! wrn-terf2-3 colocalization relationship: participates_in CCO:I0006534 ! wrn-terf2-1 physical interaction relationship: participates_in CCO:I0006535 ! wrn-p53-1 direct interaction relationship: participates_in CCO:I0006536 ! wrn-p53-2 direct interaction relationship: participates_in CCO:I0006875 ! wrn-terf2-4 direct interaction relationship: participates_in CCO:I0006876 ! wrn-terf2-5 direct interaction relationship: participates_in CCO:I0006877 ! wrn-terf2-6 direct interaction relationship: participates_in CCO:I0006878 ! wrn-terf2-7 direct interaction relationship: participates_in CCO:I0006981 ! wrn-terf2-2 physical interaction relationship: participates_in CCO:I0007127 ! wrn-rad52-6 physical interaction relationship: participates_in CCO:I0007128 ! wrn-rad52-7 physical interaction relationship: participates_in CCO:I0007436 ! wrn-rad52-1 physical interaction relationship: participates_in CCO:I0007439 ! wrn-rad52-2 direct interaction relationship: participates_in CCO:I0007440 ! wrn-rad52-3 direct interaction relationship: participates_in CCO:I0007441 ! wrn-rad52-4 direct interaction relationship: participates_in CCO:I0007442 ! wrn-rad52-5 direct interaction relationship: participates_in CCO:I0007573 ! wrn-terf2-8 direct interaction relationship: participates_in CCO:I0007578 ! p53-wrn-1 direct interaction relationship: participates_in CCO:I0007579 ! p53-wrn-2 direct interaction relationship: participates_in CCO:I0008566 ! wrn-blm-11 physical interaction relationship: participates_in CCO:I0008570 ! wrn-blm-4 colocalization relationship: participates_in CCO:I0008571 ! wrn-blm-6 direct interaction relationship: participates_in CCO:I0008572 ! wrn-blm-7 direct interaction relationship: participates_in CCO:I0008573 ! wrn-blm-9 direct interaction relationship: participates_in CCO:I0008574 ! wrn-blm-2 colocalization relationship: participates_in CCO:I0008575 ! wrn-blm-5 physical interaction relationship: participates_in CCO:I0008578 ! wrn-blm-3 colocalization relationship: participates_in CCO:I0008584 ! wrn-blm-1 direct interaction relationship: transforms_into CCO:B0014697 ! WRN_HUMAN-Phosphoserine1058 relationship: transforms_into CCO:B0014698 ! WRN_HUMAN-Phosphoserine1141 [Term] id: CCO:B0005360 name: MRGBP_HUMAN def: "MRG-binding protein" [UniProtKB:Q9NV56] xref: EMBL:AAH09889.1 xref: EMBL:AAH14235.1 xref: EMBL:AAH18841.1 xref: EMBL:BAA91902.1 xref: EMBL:CAC12748.1 xref: UniProtKB:Q9NV56 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005125 ! MRGBP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006035 ! mrgbp-ruvbl1-1 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0006041 ! tclf1-ruvbl1-6 physical interaction relationship: participates_in CCO:I0007072 ! c20orf20-epc1-2 physical interaction relationship: participates_in CCO:I0007410 ! c20orf20-epc1-4 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: participates_in CCO:I0007772 ! mrgbp-ruvbl1 physical interaction relationship: participates_in CCO:I0007780 ! mrgbp-ruvbl1-2 physical interaction [Term] id: CCO:B0005361 name: VPS72_HUMAN def: "Vacuolar protein sorting-associated protein 72 homolog" [UniProtKB:Q15906] synonym: "Protein YL-1" EXACT [UniProtKB:Q15906] synonym: "Transcription factor-like 1" EXACT [UniProtKB:Q15906] xref: EMBL:AAH03151.1 xref: EMBL:AAV38163.1 xref: EMBL:AAV38164.1 xref: EMBL:BAA07757.1 xref: EMBL:BAD96655.1 xref: EMBL:BAD96659.1 xref: EMBL:CAI16385.1 xref: EMBL:EAW53462.1 xref: UniProtKB:A6NLK9 xref: UniProtKB:Q15906 xref: UniProtKB:Q53GJ2 xref: UniProtKB:Q5U0R4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005906 ! VPS72_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006036 ! tclf1-ruvbl1-2 physical interaction relationship: participates_in CCO:I0006038 ! tclf1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0006041 ! tclf1-ruvbl1-6 physical interaction relationship: participates_in CCO:I0006042 ! tclf1-ruvbl1-7 physical interaction relationship: participates_in CCO:I0006982 ! tcfcl1-ruvbl1 physical interaction relationship: participates_in CCO:I0006983 ! tcfcl1-ruvbl1-1 physical interaction relationship: participates_in CCO:I0006984 ! tcfcl1-ruvbl1-2 physical interaction relationship: participates_in CCO:I0006985 ! tcfcl1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: participates_in CCO:I0007781 ! tcfl1-ruvbl1-3 physical interaction relationship: transforms_into CCO:B0014648 ! VPS72_HUMAN-Phosphothreonine168 [Term] id: CCO:B0005362 name: ZNHI1_HUMAN def: "Zinc finger HIT domain-containing protein 1" [UniProtKB:O43257] synonym: "Cyclin-G1-binding protein 1" EXACT [UniProtKB:O43257] synonym: "p18 Hamlet" EXACT [UniProtKB:O43257] synonym: "Zinc finger protein subfamily 4A member 1" EXACT [UniProtKB:O43257] xref: EMBL:AAB88578.1 xref: EMBL:AAD45833.1 xref: EMBL:AAF03558.1 xref: EMBL:AAH17333.1 xref: UniProtKB:O43257 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005970 ! ZNHIT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006037 ! znf-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006042 ! tclf1-ruvbl1-7 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: participates_in CCO:I0007773 ! znf-ruvbl physical interaction relationship: participates_in CCO:I0007782 ! znf-ruvbl1 physical interaction relationship: transforms_into CCO:B0014749 ! ZNHI1_HUMAN-Phosphothreonine103 [Term] id: CCO:B0005363 name: EAF1_HUMAN def: "ELL-associated factor 1" [UniProtKB:Q96JC9] xref: EMBL:AAH41329.1 xref: EMBL:AAK58687.1 xref: UniProtKB:Q8IW10 xref: UniProtKB:Q96JC9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004541 ! EAF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006038 ! tclf1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0006041 ! tclf1-ruvbl1-6 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: transforms_into CCO:B0011622 ! EAF1_HUMAN-Phosphoserine158 relationship: transforms_into CCO:B0011623 ! EAF1_HUMAN-Phosphoserine165 [Term] id: CCO:B0005364 name: RUVB2_HUMAN def: "RuvB-like 2" [UniProtKB:Q9Y230] synonym: "48 kDa TATA box-binding protein-interacting protein" EXACT [UniProtKB:Q9Y230] synonym: "48 kDa TBP-interacting protein" EXACT [UniProtKB:Q9Y230] synonym: "51 kDa erythrocyte cytosolic protein" EXACT [UniProtKB:Q9Y230] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9Y230] synonym: "ECP-51" EXACT [UniProtKB:Q9Y230] synonym: "Repressing pontin 52" EXACT [UniProtKB:Q9Y230] synonym: "Reptin 52" EXACT [UniProtKB:Q9Y230] synonym: "TAP54-beta" EXACT [UniProtKB:Q9Y230] synonym: "TIP49b" EXACT [UniProtKB:Q9Y230] synonym: "TIP60-associated protein 54-beta" EXACT [UniProtKB:Q9Y230] xref: EMBL:AAD34041.1 xref: EMBL:AAD38073.1 xref: EMBL:AAF87087.1 xref: EMBL:AAH00428.1 xref: EMBL:AAH04531.1 xref: EMBL:AAH08355.1 xref: EMBL:BAA76708.1 xref: EMBL:BAC11048.1 xref: EMBL:CAB46270.1 xref: EMBL:CAB66677.1 xref: EMBL:CAG38538.1 xref: UniProtKB:Q6FIB9 xref: UniProtKB:Q6PK27 xref: UniProtKB:Q9Y230 xref: UniProtKB:Q9Y361 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005549 ! RUVBL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006038 ! tclf1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0006041 ! tclf1-ruvbl1-6 physical interaction relationship: participates_in CCO:I0006042 ! tclf1-ruvbl1-7 physical interaction relationship: participates_in CCO:I0006510 ! ruvbl1-ruvbl2-1 physical interaction relationship: participates_in CCO:I0007410 ! c20orf20-epc1-4 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: participates_in CCO:I0007771 ! ruvbl2-ruvbl1 physical interaction relationship: transforms_into CCO:B0013947 ! RUVB2_HUMAN-Phosphoserine220 relationship: transforms_into CCO:B0041340 ! RUVB2_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005365 name: DMAP1_HUMAN def: "DNA methyltransferase 1-associated protein 1" [UniProtKB:Q9NPF5] synonym: "DNMAP1" EXACT [UniProtKB:Q9NPF5] synonym: "DNMT1-associated protein 1" EXACT [UniProtKB:Q9NPF5] xref: EMBL:AAF87079.1 xref: EMBL:AAH02855.1 xref: EMBL:AAH08053.1 xref: EMBL:BAA92663.1 xref: EMBL:BAB13854.1 xref: EMBL:CAB66592.1 xref: EMBL:CAB69910.1 xref: EMBL:CAD97886.1 xref: EMBL:CAI23197.1 xref: EMBL:CAL38490.1 xref: UniProtKB:Q0JSM4 xref: UniProtKB:Q5TG41 xref: UniProtKB:Q7Z3H7 xref: UniProtKB:Q9H0S8 xref: UniProtKB:Q9NPF5 xref: UniProtKB:Q9P2C2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004483 ! DMAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006038 ! tclf1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0006041 ! tclf1-ruvbl1-6 physical interaction relationship: participates_in CCO:I0006042 ! tclf1-ruvbl1-7 physical interaction relationship: participates_in CCO:I0007410 ! c20orf20-epc1-4 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: transforms_into CCO:B0011544 ! DMAP1_HUMAN-Phosphothreonine445 relationship: transforms_into CCO:B0011545 ! DMAP1_HUMAN-Phosphoserine456 [Term] id: CCO:B0005366 name: ACL6A_HUMAN def: "Actin-like protein 6A" [UniProtKB:O96019] synonym: "53 kDa BRG1-associated factor A" EXACT [UniProtKB:O96019] synonym: "Actin-related protein Baf53a" EXACT [UniProtKB:O96019] synonym: "ArpNbeta" EXACT [UniProtKB:O96019] xref: EMBL:AAC94991.1 xref: EMBL:AAH00949.1 xref: EMBL:AAH01391.1 xref: EMBL:AAH36371.1 xref: EMBL:BAA74577.1 xref: EMBL:BAB87844.1 xref: EMBL:BAB87848.1 xref: EMBL:CAB66543.1 xref: UniProtKB:O96019 xref: UniProtKB:Q8TAE5 xref: UniProtKB:Q9BVS8 xref: UniProtKB:Q9H0W6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004017 ! ACTL6A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006038 ! tclf1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0006041 ! tclf1-ruvbl1-6 physical interaction relationship: participates_in CCO:I0006042 ! tclf1-ruvbl1-7 physical interaction relationship: participates_in CCO:I0006205 ! smarca4-pb1-arid2-1 physical interaction relationship: participates_in CCO:I0007410 ! c20orf20-epc1-4 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: transforms_into CCO:B0010433 ! ACL6A_HUMAN-Phosphoserine233 [Term] id: CCO:B0005367 name: ARP6_HUMAN def: "Actin-related protein 6" [UniProtKB:Q9GZN1] synonym: "hArp6" EXACT [UniProtKB:Q9GZN1] synonym: "hARPX" EXACT [UniProtKB:Q9GZN1] xref: EMBL:AAH15107.1 xref: EMBL:AAK14934.1 xref: EMBL:BAB14588.1 xref: EMBL:BAB14640.1 xref: EMBL:BAB20762.1 xref: UniProtKB:Q9BY39 xref: UniProtKB:Q9GZN1 xref: UniProtKB:Q9H8H6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004100 ! ACTR6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006038 ! tclf1-ruvbl1-3 physical interaction relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006042 ! tclf1-ruvbl1-7 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction [Term] id: CCO:B0005368 name: ING3_HUMAN def: "Inhibitor of growth protein 3" [UniProtKB:Q9NXR8] synonym: "p47ING3 protein" EXACT [UniProtKB:Q9NXR8] xref: EMBL:AAF28979.1 xref: EMBL:AAG12172.1 xref: EMBL:AAG23285.1 xref: EMBL:AAH09776.1 xref: EMBL:AAH09777.1 xref: EMBL:AAH10851.1 xref: EMBL:AAH62634.1 xref: EMBL:AAH73865.1 xref: EMBL:AAQ93373.1 xref: EMBL:AAQ93374.1 xref: EMBL:BAA90942.1 xref: EMBL:CAC48260.2 xref: UniProtKB:O60394 xref: UniProtKB:Q6GMT3 xref: UniProtKB:Q7Z762 xref: UniProtKB:Q969G0 xref: UniProtKB:Q96DT4 xref: UniProtKB:Q9HC99 xref: UniProtKB:Q9NXR8 xref: UniProtKB:Q9P081 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004893 ! ING3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0006041 ! tclf1-ruvbl1-6 physical interaction [Term] id: CCO:B0005369 name: EPC1_HUMAN def: "Enhancer of polycomb homolog 1" [UniProtKB:Q9H2F5] xref: EMBL:AAG41402.1 xref: EMBL:AAH36529.1 xref: EMBL:AAK60501.1 xref: EMBL:BAB14888.1 xref: EMBL:BAC03857.1 xref: EMBL:CAH70452.1 xref: EMBL:CAH70453.1 xref: EMBL:CAH70454.1 xref: EMBL:CAH70455.1 xref: EMBL:CAH70820.1 xref: EMBL:CAH70821.1 xref: EMBL:CAH70822.1 xref: EMBL:CAH70823.1 xref: UniProtKB:Q5VW54 xref: UniProtKB:Q5VW56 xref: UniProtKB:Q5VW58 xref: UniProtKB:Q8NAQ4 xref: UniProtKB:Q8NE21 xref: UniProtKB:Q96LF4 xref: UniProtKB:Q96RR6 xref: UniProtKB:Q9H2F5 xref: UniProtKB:Q9H7T7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004571 ! EPC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: transforms_into CCO:B0011719 ! EPC1_HUMAN-Phosphoserine357 [Term] id: CCO:B0005370 name: MO4L2_HUMAN def: "Mortality factor 4-like protein 2" [UniProtKB:Q15014] synonym: "MORF-related gene X protein" EXACT [UniProtKB:Q15014] synonym: "MSL3-2 protein" EXACT [UniProtKB:Q15014] synonym: "Transcription factor-like protein MRGX" EXACT [UniProtKB:Q15014] xref: EMBL:AAD29873.1 xref: EMBL:AAF80855.1 xref: EMBL:AAH56899.1 xref: EMBL:AAH93013.1 xref: EMBL:BAA03553.1 xref: EMBL:BAC22659.1 xref: EMBL:CAB55701.1 xref: UniProtKB:Q15014 xref: UniProtKB:Q567V0 xref: UniProtKB:Q8J026 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005109 ! MORF4L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006561 ! morf4l2-rb1-1 physical interaction relationship: participates_in CCO:I0007410 ! c20orf20-epc1-4 physical interaction [Term] id: CCO:B0005371 name: EPC2_HUMAN def: "Enhancer of polycomb homolog 2" [UniProtKB:Q52LR7] synonym: "EPC-like" EXACT [UniProtKB:Q52LR7] xref: EMBL:AAH93818.1 xref: EMBL:AAH93820.1 xref: EMBL:AAK60500.1 xref: EMBL:BAA91688.1 xref: EMBL:BAA92032.1 xref: EMBL:CAB55993.1 xref: UniProtKB:Q52LR7 xref: UniProtKB:Q7L9J1 xref: UniProtKB:Q96RR7 xref: UniProtKB:Q9NUT8 xref: UniProtKB:Q9NVR1 xref: UniProtKB:Q9UFM9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004572 ! EPC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction [Term] id: CCO:B0005372 name: ADAM9_HUMAN def: "ADAM 9 precursor" [UniProtKB:Q13443] synonym: "A disintegrin and metalloproteinase domain 9" EXACT [UniProtKB:Q13443] synonym: "Cellular disintegrin-related protein" EXACT [UniProtKB:Q13443] synonym: "EC 3.4.24.-" EXACT [UniProtKB:Q13443] synonym: "Meltrin-gamma" EXACT [UniProtKB:Q13443] synonym: "Metalloprotease/disintegrin/cysteine-rich protein 9" EXACT [UniProtKB:Q13443] synonym: "Myeloma cell metalloproteinase" EXACT [UniProtKB:Q13443] xref: EMBL:AAC50403.1 xref: EMBL:AAM49575.1 xref: EMBL:BAA03499.2 xref: UniProtKB:Q10718 xref: UniProtKB:Q13443 xref: UniProtKB:Q8NFM6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004029 ! ADAM9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006043 ! adam9-mad2l2-3 physical interaction relationship: participates_in CCO:I0006628 ! adam9-mad2l2-2 physical interaction relationship: participates_in CCO:I0007286 ! adam9-mad2l2-1 physical interaction relationship: transforms_into CCO:B0010458 ! ADAM9_HUMAN-Phosphoserine758 relationship: transforms_into CCO:B0010459 ! ADAM9_HUMAN-Phosphothreonine761 [Term] id: CCO:B0005373 name: TPD52_HUMAN def: "Tumor protein D52" [UniProtKB:P55327] synonym: "Protein N8" EXACT [UniProtKB:P55327] xref: EMBL:AAB36475.1 xref: EMBL:AAC50183.1 xref: EMBL:AAH18117.1 xref: UniProtKB:P55327 xref: UniProtKB:Q13056 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005816 ! TPD52_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006044 ! hd52-hd53-1 physical interaction relationship: participates_in CCO:I0006045 ! hd53-hd52-1 physical interaction relationship: participates_in CCO:I0007586 ! hd52-hd53-2 physical interaction relationship: transforms_into CCO:B0014510 ! TPD52_HUMAN-Phosphoserine131 relationship: transforms_into CCO:B0014511 ! TPD52_HUMAN-Phosphothreonine133 relationship: transforms_into CCO:B0014512 ! TPD52_HUMAN-Phosphoserine136 [Term] id: CCO:B0005374 name: APLP2_HUMAN def: "Amyloid-like protein 2 precursor" [UniProtKB:Q06481] synonym: "Amyloid protein homolog" EXACT [UniProtKB:Q06481] synonym: "APPH" EXACT [UniProtKB:Q06481] synonym: "CDEBP" EXACT [UniProtKB:Q06481] synonym: "CDEI box-binding protein" EXACT [UniProtKB:Q06481] xref: EMBL:AAA35526.1 xref: EMBL:AAA35601.1 xref: EMBL:AAA36032.1 xref: EMBL:AAA36130.1 xref: EMBL:AAC41701.1 xref: EMBL:AAC60589.1 xref: EMBL:AAD47291.1 xref: EMBL:AAH00373.1 xref: EMBL:AAH04371.1 xref: EMBL:CAA80295.1 xref: UniProtKB:Q06481 xref: UniProtKB:Q13861 xref: UniProtKB:Q14594 xref: UniProtKB:Q14662 xref: UniProtKB:Q71U10 xref: UniProtKB:Q7M4L3 xref: UniProtKB:Q9BT36 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004083 ! APLP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006047 ! aplp2-apbb2-1 physical interaction relationship: participates_in CCO:I0007060 ! apbb1-aplp2-1 physical interaction [Term] id: CCO:B0005375 name: STK36_HUMAN def: "Serine/threonine-protein kinase 36" [UniProtKB:Q9NRP7] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9NRP7] synonym: "Fused homolog" EXACT [UniProtKB:Q9NRP7] xref: EMBL:AAF97028.1 xref: EMBL:AAH26158.1 xref: EMBL:BAA86592.1 xref: EMBL:BAB14184.1 xref: EMBL:CAB63754.1 xref: UniProtKB:Q8TC32 xref: UniProtKB:Q9H9N9 xref: UniProtKB:Q9NRP7 xref: UniProtKB:Q9UF35 xref: UniProtKB:Q9ULE2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005693 ! STK36_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006048 ! stk36-sufu-1 physical interaction relationship: participates_in CCO:I0006049 ! stk36-sufu-2 physical interaction [Term] id: CCO:B0005376 name: NP1L1_HUMAN def: "Nucleosome assembly protein 1-like 1" [UniProtKB:P55209] synonym: "hNRP" EXACT [UniProtKB:P55209] synonym: "NAP-1-related protein" EXACT [UniProtKB:P55209] xref: EMBL:AAC37544.1 xref: EMBL:AAH02387.1 xref: EMBL:AAP35669.1 xref: EMBL:CAB82405.1 xref: UniProtKB:P55209 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005210 ! NAP1L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006050 ! ep300-nap1l1-3 direct interaction relationship: participates_in CCO:I0007787 ! ep300-nap1l1-4 physical interaction relationship: participates_in CCO:I0007788 ! ep300-nap1l1-5 physical interaction relationship: participates_in CCO:I0008655 ! nap1l1-fsd1 physical interaction relationship: transforms_into CCO:B0013244 ! NP1L1_HUMAN-Phosphoserine10 relationship: transforms_into CCO:B0013245 ! NP1L1_HUMAN-Phosphothreonine62 [Term] id: CCO:B0005377 name: AP2C_HUMAN def: "Transcription factor AP-2 gamma" [UniProtKB:Q92754] synonym: "Activating enhancer-binding protein 2 gamma" EXACT [UniProtKB:Q92754] synonym: "AP2-gamma" EXACT [UniProtKB:Q92754] synonym: "Transcription factor ERF-1" EXACT [UniProtKB:Q92754] xref: EMBL:AAC51305.1 xref: EMBL:AAH35664.2 xref: EMBL:AAH51829.2 xref: EMBL:BAC11805.1 xref: EMBL:CAA64989.1 xref: EMBL:CAC10334.1 xref: EMBL:CAC86997.1 xref: UniProtKB:O00685 xref: UniProtKB:O00730 xref: UniProtKB:Q86V30 xref: UniProtKB:Q8IVB6 xref: UniProtKB:Q92754 xref: UniProtKB:Q9P1X2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004075 ! TFAP2C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006056 ! ap2g-ubc9-1 physical interaction relationship: participates_in CCO:I0006893 ! cited2-tfap2c-1 physical interaction relationship: participates_in CCO:I0007793 ! tfap2c-cited2-1 physical interaction relationship: participates_in CCO:I0007920 ! ap2g-ubc9-2 physical interaction relationship: participates_in CCO:I0007923 ! ubc9-ap2g-1 physical interaction relationship: transforms_into CCO:B0010566 ! AP2C_HUMAN-Phosphoserine252 [Term] id: CCO:B0005378 name: S100B_HUMAN def: "Protein S100-B" [UniProtKB:P04271] synonym: "S-100 protein beta chain" EXACT [UniProtKB:P04271] synonym: "S-100 protein subunit beta" EXACT [UniProtKB:P04271] synonym: "S100 calcium-binding protein B" EXACT [UniProtKB:P04271] xref: EMBL:AAA60367.1 xref: EMBL:AAH01766.1 xref: EMBL:CAG46920.1 xref: UniProtKB:P04271 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005551 ! S100B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006057 ! s100b-s100a6-1 physical interaction relationship: participates_in CCO:I0006219 ! s100b-s100a6-3 physical interaction relationship: participates_in CCO:I0006895 ! s100a6-s100b-1 physical interaction relationship: participates_in CCO:I0006896 ! s100b-s100a6-2 physical interaction relationship: participates_in CCO:I0007148 ! s100b-s100a11-s100a6 colocalization relationship: transforms_into CCO:B0013948 ! S100B_HUMAN-Blocked amino end (Ser)2 [Term] id: CCO:B0005379 name: STAT3_HUMAN def: "Signal transducer and activator of transcription 3" [UniProtKB:P40763] synonym: "Acute-phase response factor" EXACT [UniProtKB:P40763] xref: EMBL:AAA58374.1 xref: EMBL:AAB84254.1 xref: EMBL:AAH00627.1 xref: EMBL:AAH14482.1 xref: EMBL:AAS66986.1 xref: EMBL:CAA10032.1 xref: UniProtKB:O14916 xref: UniProtKB:P40763 xref: UniProtKB:Q9BW54 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005687 ! STAT3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007346 ! khdrbs1-stat3-1 physical interaction relationship: participates_in CCO:I0007347 ! khdrbs1-stat3-2 physical interaction relationship: transforms_into CCO:B0014245 ! STAT3_HUMAN-Phosphoserine691 relationship: transforms_into CCO:B0014246 ! STAT3_HUMAN-Phosphotyrosine705 relationship: transforms_into CCO:B0014247 ! STAT3_HUMAN-Phosphoserine727 [Term] id: CCO:B0005380 name: AIP_HUMAN def: "AH receptor-interacting protein" [UniProtKB:O00170] synonym: "AIP" EXACT [UniProtKB:O00170] synonym: "Aryl-hydrocarbon receptor-interacting protein" EXACT [UniProtKB:O00170] synonym: "HBV X-associated protein 2" EXACT [UniProtKB:O00170] synonym: "Immunophilin homolog ARA9" EXACT [UniProtKB:O00170] synonym: "XAP-2" EXACT [UniProtKB:O00170] xref: EMBL:AAB39923.1 xref: EMBL:AAB59004.1 xref: EMBL:AAI04798.1 xref: EMBL:AAI04828.1 xref: EMBL:CAJ85657.1 xref: UniProtKB:O00170 xref: UniProtKB:Q2M3Q2 xref: UniProtKB:Q99606 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004040 ! AIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006062 ! ahr-aip colocalization relationship: participates_in CCO:I0006063 ! ahr-aip-1 colocalization relationship: participates_in CCO:I0007813 ! ahr-aip-2 physical interaction relationship: transforms_into CCO:B0010481 ! AIP_HUMAN-Phosphotyrosine248 [Term] id: CCO:B0005382 name: NFYB_HUMAN def: "Nuclear transcription factor Y subunit beta" [UniProtKB:P25208] synonym: "CAAT-box DNA-binding protein subunit B" EXACT [UniProtKB:P25208] synonym: "NF-YB" EXACT [UniProtKB:P25208] synonym: "Nuclear transcription factor Y subunit B" EXACT [UniProtKB:P25208] xref: EMBL:AAA59930.1 xref: EMBL:AAH05316.1 xref: EMBL:AAH05317.1 xref: EMBL:AAH07035.1 xref: EMBL:CAA42230.1 xref: UniProtKB:P25208 xref: UniProtKB:Q96IY8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005190 ! NFYB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006562 ! tp53-nfya-2 physical interaction relationship: participates_in CCO:I0006920 ! tp53-nfya-6 physical interaction relationship: participates_in CCO:I0006921 ! nfya-tp53-2 physical interaction relationship: participates_in CCO:I0007707 ! tp53-nfya physical interaction relationship: participates_in CCO:I0007824 ! tp53-nfya-1 physical interaction [Term] id: CCO:B0005383 name: SOS1_HUMAN def: "Son of sevenless homolog 1" [UniProtKB:Q07889] synonym: "SOS-1" EXACT [UniProtKB:Q07889] xref: EMBL:AAA35913.1 xref: UniProtKB:Q07889 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005649 ! SOS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006843 ! sos1-cd2ap-1 physical interaction relationship: transforms_into CCO:B0014152 ! SOS1_HUMAN-Phosphoserine1043 relationship: transforms_into CCO:B0014153 ! SOS1_HUMAN-Phosphoserine1078 relationship: transforms_into CCO:B0014154 ! SOS1_HUMAN-Phosphoserine1082 relationship: transforms_into CCO:B0014155 ! SOS1_HUMAN-Phosphoserine1210 [Term] id: CCO:B0005384 name: NFYA_HUMAN def: "Nuclear transcription factor Y subunit alpha" [UniProtKB:P23511] synonym: "CAAT-box DNA-binding protein subunit A" EXACT [UniProtKB:P23511] synonym: "NF-YA" EXACT [UniProtKB:P23511] synonym: "Nuclear transcription factor Y subunit A" EXACT [UniProtKB:P23511] xref: EMBL:AAA35950.1 xref: EMBL:AAH39244.1 xref: EMBL:CAA42231.1 xref: EMBL:CAB44743.1 xref: EMBL:CAI20286.1 xref: UniProtKB:P23511 xref: UniProtKB:Q8IXU0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005189 ! NFYA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006070 ! tp53-nfya-8 colocalization relationship: participates_in CCO:I0006562 ! tp53-nfya-2 physical interaction relationship: participates_in CCO:I0006564 ! tp53-nfya-3 physical interaction relationship: participates_in CCO:I0006565 ! tp53-nfya-4 physical interaction relationship: participates_in CCO:I0006567 ! tp53-nfya-7 physical interaction relationship: participates_in CCO:I0006917 ! nfya-tp53 physical interaction relationship: participates_in CCO:I0006918 ! nfya-tp53-1 physical interaction relationship: participates_in CCO:I0006919 ! tp53-nfya-5 physical interaction relationship: participates_in CCO:I0006920 ! tp53-nfya-6 physical interaction relationship: participates_in CCO:I0007707 ! tp53-nfya physical interaction relationship: participates_in CCO:I0007824 ! tp53-nfya-1 physical interaction [Term] id: CCO:B0005385 name: RIN1_HUMAN def: "Ras and Rab interactor 1" [UniProtKB:Q13671] synonym: "Ras inhibitor JC99" EXACT [UniProtKB:Q13671] synonym: "Ras interaction/interference protein 1" EXACT [UniProtKB:Q13671] xref: EMBL:AAB67270.1 xref: EMBL:AAH14417.1 xref: UniProtKB:O15010 xref: UniProtKB:Q00427 xref: UniProtKB:Q13671 xref: UniProtKB:Q96CC8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005490 ! RIN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006071 ! abl1-rin1-3 physical interaction relationship: participates_in CCO:I0006922 ! abl1-rin1-1 physical interaction relationship: participates_in CCO:I0006923 ! abl1-rin1-2 physical interaction relationship: participates_in CCO:I0007171 ! abl1-rin1-4 phosphorylation relationship: transforms_into CCO:B0013870 ! RIN1_HUMAN-Phosphotyrosine36 relationship: transforms_into CCO:B0013871 ! RIN1_HUMAN-Phosphoserine333 relationship: transforms_into CCO:B0013872 ! RIN1_HUMAN-Phosphoserine337 relationship: transforms_into CCO:B0013873 ! RIN1_HUMAN-Phosphoserine351 relationship: transforms_into CCO:B0013874 ! RIN1_HUMAN-Phosphoserine601 [Term] id: CCO:B0005386 name: FNBP1_HUMAN def: "Formin-binding protein 1" [UniProtKB:Q96RU3] synonym: "Formin-binding protein 17" EXACT [UniProtKB:Q96RU3] synonym: "hFBP17" EXACT [UniProtKB:Q96RU3] xref: EMBL:AAH62463.1 xref: EMBL:AAI01756.1 xref: EMBL:AAK49824.1 xref: EMBL:BAA25480.1 xref: EMBL:BAA91451.1 xref: EMBL:BAB14638.1 xref: EMBL:CAI12149.1 xref: EMBL:CAI12150.1 xref: EMBL:CAI13910.1 xref: EMBL:CAI13911.1 xref: UniProtKB:O60301 xref: UniProtKB:Q3MIN8 xref: UniProtKB:Q5TC87 xref: UniProtKB:Q5TC88 xref: UniProtKB:Q6P658 xref: UniProtKB:Q7LGG2 xref: UniProtKB:Q96RU3 xref: UniProtKB:Q9H8H8 xref: UniProtKB:Q9NWD1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004651 ! FNBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006072 ! fnbp1-dnm2-2 physical interaction relationship: participates_in CCO:I0007506 ! fnbp1-dnm2-1 colocalization relationship: transforms_into CCO:B0011885 ! FNBP1_HUMAN-Phosphothreonine294 relationship: transforms_into CCO:B0011886 ! FNBP1_HUMAN-Phosphoserine296 relationship: transforms_into CCO:B0011887 ! FNBP1_HUMAN-Phosphoserine299 relationship: transforms_into CCO:B0011888 ! FNBP1_HUMAN-Phosphotyrosine522 relationship: transforms_into CCO:B0031318 ! FNBP1_HUMAN-Phosphoserine497 relationship: transforms_into CCO:B0031319 ! FNBP1_HUMAN-Phosphotyrosine500 [Term] id: CCO:B0005387 name: TELT_HUMAN def: "Telethonin" [UniProtKB:O15273] synonym: "Titin cap protein" EXACT [UniProtKB:O15273] xref: EMBL:AAH12628.1 xref: EMBL:AAH13330.1 xref: EMBL:CAA04129.1 xref: EMBL:CAA08987.1 xref: EMBL:CAA09479.1 xref: UniProtKB:O15273 xref: UniProtKB:Q96L27 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005759 ! TCAP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006073 ! ttn-tcap direct interaction [Term] id: CCO:B0005388 name: ORC6_HUMAN def: "Origin recognition complex subunit 6" [UniProtKB:Q9Y5N6] xref: EMBL:AAD32666.1 xref: EMBL:AAH39032.1 xref: EMBL:AAH63565.1 xref: UniProtKB:Q9Y5N6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005237 ! ORC6L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006074 ! mcm2-orc6l direct interaction relationship: participates_in CCO:I0006081 ! orc6l-mcm6 direct interaction relationship: participates_in CCO:I0006090 ! orc6l-cdc7 direct interaction relationship: participates_in CCO:I0006124 ! hscdc6-orc6l direct interaction relationship: participates_in CCO:I0006126 ! orc6l-mcm7 direct interaction relationship: transforms_into CCO:B0013336 ! ORC6_HUMAN-Phosphothreonine195 relationship: transforms_into CCO:B0013337 ! ORC6_HUMAN-Phosphothreonine229 [Term] id: CCO:B0005389 name: ORC4_HUMAN def: "Origin recognition complex subunit 4" [UniProtKB:O43929] xref: EMBL:AAC01957.1 xref: EMBL:AAC80282.1 xref: EMBL:AAD22110.1 xref: EMBL:AAH14847.1 xref: EMBL:AAS94326.1 xref: UniProtKB:O43929 xref: UniProtKB:Q96C42 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005235 ! ORC4L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006079 ! orc4l-mcm7 direct interaction relationship: participates_in CCO:I0006091 ! orc4l-ccnd1 direct interaction relationship: participates_in CCO:I0006096 ! orc4l-mcm3 direct interaction relationship: participates_in CCO:I0006117 ! orc4l-cdkn2a direct interaction [Term] id: CCO:B0005390 name: ORC5_HUMAN def: "Origin recognition complex subunit 5" [UniProtKB:O43913] xref: EMBL:AAC51933.1 xref: EMBL:AAC63972.1 xref: EMBL:AAC80283.1 xref: EMBL:AAH23652.1 xref: UniProtKB:O43913 xref: UniProtKB:O60590 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005236 ! ORC5L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006088 ! orc5l-cdc45l direct interaction relationship: participates_in CCO:I0006093 ! mcm3-orc5l direct interaction relationship: participates_in CCO:I0006110 ! mcm2-orc5l direct interaction relationship: participates_in CCO:I0006122 ! hscdc6-orc5l direct interaction relationship: participates_in CCO:I0006133 ! cdkn2a-orc5l direct interaction relationship: participates_in CCO:I0006138 ! cdc7-orc5l direct interaction [Term] id: CCO:B0005391 name: MCM4_HUMAN def: "DNA replication licensing factor MCM4" [UniProtKB:P33991] synonym: "CDC21 homolog" EXACT [UniProtKB:P33991] synonym: "P1-CDC21" EXACT [UniProtKB:P33991] xref: EMBL:AAB51723.3 xref: EMBL:AAC52018.1 xref: EMBL:AAH31061.1 xref: EMBL:AAS83108.1 xref: EMBL:CAA52801.1 xref: UniProtKB:P33991 xref: UniProtKB:Q8NEH1 xref: UniProtKB:Q99658 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005039 ! MCM4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006099 ! mcm4-hscdc5 direct interaction relationship: participates_in CCO:I0006153 ! mcm4-mcm7 direct interaction relationship: participates_in CCO:I0006157 ! mcm4-ccna1 direct interaction relationship: participates_in CCO:I0007542 ! mcm4-mcm6-1 physical interaction relationship: participates_in CCO:I0007914 ! mcm2-7_human physical interaction relationship: transforms_into CCO:B0012826 ! MCM4_HUMAN-Phosphothreonine19 relationship: transforms_into CCO:B0012827 ! MCM4_HUMAN-Phosphoserine26 relationship: transforms_into CCO:B0012828 ! MCM4_HUMAN-Phosphoserine32 relationship: transforms_into CCO:B0012829 ! MCM4_HUMAN-Phosphoserine105 relationship: transforms_into CCO:B0012830 ! MCM4_HUMAN-Phosphothreonine110 relationship: transforms_into CCO:B0012831 ! MCM4_HUMAN-Phosphoserine120 relationship: transforms_into CCO:B0012832 ! MCM4_HUMAN-Phosphoserine131 relationship: transforms_into CCO:B0012833 ! MCM4_HUMAN-Phosphoserine142 relationship: transforms_into CCO:B0012834 ! MCM4_HUMAN-Phosphoserine145 relationship: transforms_into CCO:B0012835 ! MCM4_HUMAN-Phosphoserine326 [Term] id: CCO:B0005392 name: ORC3_HUMAN def: "Origin recognition complex subunit 3" [UniProtKB:Q9UBD5] synonym: "Origin recognition complex subunit Latheo" EXACT [UniProtKB:Q9UBD5] xref: EMBL:AAA96313.1 xref: EMBL:AAD18057.1 xref: EMBL:AAD30282.1 xref: EMBL:AAD40220.1 xref: EMBL:AAH35494.1 xref: EMBL:AAH47689.1 xref: EMBL:AAT38109.1 xref: EMBL:BAD96515.1 xref: EMBL:CAB45715.1 xref: EMBL:CAI10900.1 xref: EMBL:CAI21539.1 xref: EMBL:CAM13063.1 xref: EMBL:CAM28255.1 xref: UniProtKB:A2A2T5 xref: UniProtKB:Q13565 xref: UniProtKB:Q53GY6 xref: UniProtKB:Q5T159 xref: UniProtKB:Q6IUY7 xref: UniProtKB:Q86TN5 xref: UniProtKB:Q9UBD5 xref: UniProtKB:Q9UG44 xref: UniProtKB:Q9UNT6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005234 ! ORC3L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006107 ! orc3l-ccne2 direct interaction relationship: participates_in CCO:I0006109 ! mcm7-orc3l direct interaction relationship: participates_in CCO:I0006123 ! orc3l-hscdc6 direct interaction relationship: transforms_into CCO:B0013334 ! ORC3_HUMAN-Phosphoserine208 relationship: transforms_into CCO:B0013335 ! ORC3_HUMAN-Phosphoserine516 [Term] id: CCO:B0005393 name: FEZ1_HUMAN def: "Fasciculation and elongation protein zeta-1" [UniProtKB:Q99689] synonym: "Zygin I" EXACT [UniProtKB:Q99689] synonym: "Zygin-1" EXACT [UniProtKB:Q99689] xref: EMBL:AAB40660.1 xref: EMBL:AAC51282.1 xref: EMBL:AAC51284.1 xref: EMBL:AAH09545.1 xref: EMBL:CAG33098.1 xref: EMBL:CAG46752.1 xref: UniProtKB:O00679 xref: UniProtKB:O00728 xref: UniProtKB:Q6IBI7 xref: UniProtKB:Q99689 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004629 ! FEZ1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006164 ! nek1-fez1-2 physical interaction relationship: participates_in CCO:I0006179 ! bard1-fez1 physical interaction relationship: participates_in CCO:I0007268 ! nek1-fez1-3 physical interaction relationship: participates_in CCO:I0008389 ! flj22624-fez1 physical interaction relationship: transforms_into CCO:B0011875 ! FEZ1_HUMAN-Phosphoserine58 [Term] id: CCO:B0005394 name: FEZ2_HUMAN def: "Fasciculation and elongation protein zeta-2" [UniProtKB:Q9UHY8] synonym: "Zygin II" EXACT [UniProtKB:Q9UHY8] synonym: "Zygin-2" EXACT [UniProtKB:Q9UHY8] xref: EMBL:AAB40661.1 xref: EMBL:AAC51283.1 xref: EMBL:AAF14865.1 xref: EMBL:AAY14650.1 xref: EMBL:BAD06207.1 xref: UniProtKB:Q76LN0 xref: UniProtKB:Q99690 xref: UniProtKB:Q9UHY8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004630 ! FEZ2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006165 ! nek1-fez2-1 physical interaction relationship: participates_in CCO:I0007235 ! nek1-fez2-2 physical interaction [Term] id: CCO:B0005395 name: ZHX1_HUMAN def: "Zinc fingers and homeoboxes protein 1" [UniProtKB:Q9UKY1] xref: EMBL:AAD50624.1 xref: EMBL:AAF35183.1 xref: EMBL:AAH40481.1 xref: UniProtKB:Q8IWD8 xref: UniProtKB:Q9UKY1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005956 ! ZHX1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006167 ! bard1-zhx1 physical interaction relationship: participates_in CCO:I0008136 ! mphosph6-zhx1 physical interaction relationship: participates_in CCO:I0008174 ! terf1-zhx1 physical interaction relationship: transforms_into CCO:B0014740 ! ZHX1_HUMAN-Phosphothreonine36 relationship: transforms_into CCO:B0014741 ! ZHX1_HUMAN-Phosphoserine45 relationship: transforms_into CCO:B0014742 ! ZHX1_HUMAN-Phosphoserine47 relationship: transforms_into CCO:B0014743 ! ZHX1_HUMAN-Phosphoserine48 relationship: transforms_into CCO:B0014744 ! ZHX1_HUMAN-Phosphoserine648 relationship: transforms_into CCO:B0014745 ! ZHX1_HUMAN-Phosphothreonine682 [Term] id: CCO:B0005396 name: TCRG1_HUMAN def: "Transcription elongation regulator 1" [UniProtKB:O14776] synonym: "TATA box-binding protein-associated factor 2S" EXACT [UniProtKB:O14776] synonym: "Transcription factor CA150" EXACT [UniProtKB:O14776] xref: EMBL:AAB80727.1 xref: EMBL:AAI11728.1 xref: EMBL:BAD93147.1 xref: UniProtKB:O14776 xref: UniProtKB:Q2NKN2 xref: UniProtKB:Q59EA1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005755 ! TCERG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006168 ! bard1-tcerg1-1 physical interaction relationship: participates_in CCO:I0007082 ! bard1-tcerg1 physical interaction relationship: transforms_into CCO:B0014326 ! TCRG1_HUMAN-Phosphoserine481 relationship: transforms_into CCO:B0014327 ! TCRG1_HUMAN-Phosphothreonine489 [Term] id: CCO:B0005397 name: GIT1_HUMAN def: "ARF GTPase-activating protein GIT1" [UniProtKB:Q9Y2X7] synonym: "Cat-1" EXACT [UniProtKB:Q9Y2X7] synonym: "Cool-associated and tyrosine-phosphorylated protein 1" EXACT [UniProtKB:Q9Y2X7] synonym: "G protein-coupled receptor kinase-interactor 1" EXACT [UniProtKB:Q9Y2X7] synonym: "GRK-interacting protein 1" EXACT [UniProtKB:Q9Y2X7] xref: EMBL:AAD28046.1 xref: EMBL:AAH06227.2 xref: EMBL:AAH48196.1 xref: UniProtKB:Q86SS0 xref: UniProtKB:Q9BRJ4 xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004699 ! GIT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006169 ! bard1-git1-1 physical interaction relationship: participates_in CCO:I0007078 ! bard1-git1 physical interaction relationship: participates_in CCO:I0008043 ! rgs2-git1 physical interaction relationship: participates_in CCO:I0008143 ! pfdn1-git1 physical interaction relationship: participates_in CCO:I0008150 ! pmf1-git1 physical interaction relationship: participates_in CCO:I0008172 ! terf1-git1 physical interaction relationship: transforms_into CCO:B0011932 ! GIT1_HUMAN-Phosphoserine134 relationship: transforms_into CCO:B0011933 ! GIT1_HUMAN-Phosphoserine361 relationship: transforms_into CCO:B0011934 ! GIT1_HUMAN-Phosphoserine362 relationship: transforms_into CCO:B0011935 ! GIT1_HUMAN-Phosphoserine385 relationship: transforms_into CCO:B0011936 ! GIT1_HUMAN-Phosphoserine388 relationship: transforms_into CCO:B0011937 ! GIT1_HUMAN-Phosphotyrosine545 relationship: transforms_into CCO:B0011938 ! GIT1_HUMAN-Phosphotyrosine554 relationship: transforms_into CCO:B0011939 ! GIT1_HUMAN-Phosphoserine592 relationship: transforms_into CCO:B0011940 ! GIT1_HUMAN-Phosphotyrosine598 relationship: transforms_into CCO:B0031327 ! GIT1_HUMAN-Phosphotyrosine224 [Term] id: CCO:B0005398 name: ELP1_HUMAN def: "Elongator complex protein 1" [UniProtKB:O95163] synonym: "ELP1" EXACT [UniProtKB:O95163] synonym: "IkappaB kinase complex-associated protein" EXACT [UniProtKB:O95163] synonym: "IKK complex-associated protein" EXACT [UniProtKB:O95163] synonym: "p150" EXACT [UniProtKB:O95163] xref: EMBL:AAC64258.1 xref: EMBL:AAG43369.1 xref: EMBL:CAB43219.1 xref: UniProtKB:O95163 xref: UniProtKB:Q9H327 xref: UniProtKB:Q9UG87 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004563 ! IKBKAP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006170 ! bard1-ikbkap physical interaction relationship: participates_in CCO:I0008212 ! cdkn2b-ikbkap physical interaction [Term] id: CCO:B0005399 name: MYST2_HUMAN def: "Histone acetyltransferase MYST2" [UniProtKB:O95251] synonym: "EC 2.3.1.48" EXACT [UniProtKB:O95251] synonym: "Histone acetyltransferase binding to ORC1" EXACT [UniProtKB:O95251] synonym: "MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2" EXACT [UniProtKB:O95251] synonym: "MYST protein 2" EXACT [UniProtKB:O95251] xref: EMBL:AAC99368.1 xref: EMBL:AAD42348.1 xref: EMBL:AAH32640.1 xref: EMBL:AAL56649.1 xref: UniProtKB:O95251 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005151 ! MYST2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006171 ! bard1-hbo1-1 physical interaction relationship: participates_in CCO:I0007079 ! bard1-hbo1 physical interaction relationship: participates_in CCO:I0008294 ! sept5-myst2 physical interaction relationship: transforms_into CCO:B0013074 ! MYST2_HUMAN-Phosphoserine50 relationship: transforms_into CCO:B0013075 ! MYST2_HUMAN-Phosphoserine52 relationship: transforms_into CCO:B0013076 ! MYST2_HUMAN-Phosphoserine53 relationship: transforms_into CCO:B0013077 ! MYST2_HUMAN-Phosphoserine56 relationship: transforms_into CCO:B0013078 ! MYST2_HUMAN-Phosphoserine57 relationship: transforms_into CCO:B0013079 ! MYST2_HUMAN-Phosphothreonine88 relationship: transforms_into CCO:B0013080 ! MYST2_HUMAN-Phosphoserine99 relationship: transforms_into CCO:B0013081 ! MYST2_HUMAN-Phosphoserine100 relationship: transforms_into CCO:B0013082 ! MYST2_HUMAN-Phosphoserine102 relationship: transforms_into CCO:B0013083 ! MYST2_HUMAN-Phosphoserine124 relationship: transforms_into CCO:B0013084 ! MYST2_HUMAN-Phosphothreonine128 [Term] id: CCO:B0005400 name: BRD7_HUMAN def: "Bromodomain-containing protein 7" [UniProtKB:Q9NPI1] synonym: "75 kDa bromodomain protein" EXACT [UniProtKB:Q9NPI1] synonym: "Protein CELTIX-1" EXACT [UniProtKB:Q9NPI1] xref: EMBL:AAF19526.1 xref: EMBL:AAF75126.1 xref: EMBL:AAH01611.1 xref: EMBL:AAH50728.1 xref: EMBL:AAH94706.1 xref: EMBL:BAB55031.1 xref: EMBL:BAC11089.1 xref: EMBL:CAB72445.1 xref: UniProtKB:Q4VC09 xref: UniProtKB:Q8N2L9 xref: UniProtKB:Q96KA4 xref: UniProtKB:Q9BV48 xref: UniProtKB:Q9NPI1 xref: UniProtKB:Q9UH59 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004189 ! BRD7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006172 ! bard1-bp465 physical interaction relationship: transforms_into CCO:B0010865 ! BRD7_HUMAN-Phosphoserine279 [Term] id: CCO:B0005401 name: KBTB7_HUMAN def: "Kelch repeat and BTB domain-containing protein 7" [UniProtKB:Q8WVZ9] xref: EMBL:AAH22033.1 xref: EMBL:BAC03641.1 xref: EMBL:CAB66716.1 xref: EMBL:CAI16613.1 xref: EMBL:EAX08647.1 xref: UniProtKB:Q5T6Y7 xref: UniProtKB:Q8NB99 xref: UniProtKB:Q8WVZ9 xref: UniProtKB:Q9H0I6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004931 ! KBTBD7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006173 ! bard1-kbtbd7 physical interaction [Term] id: CCO:B0005402 name: PIAS4_HUMAN def: "E3 SUMO-protein ligase PIAS4" [UniProtKB:Q8N2W9] synonym: "PIAS-gamma" EXACT [UniProtKB:Q8N2W9] synonym: "PIASy" EXACT [UniProtKB:Q8N2W9] synonym: "Protein inhibitor of activated STAT protein 4" EXACT [UniProtKB:Q8N2W9] synonym: "Protein inhibitor of activated STAT protein gamma" EXACT [UniProtKB:Q8N2W9] xref: EMBL:AAC36703.1 xref: EMBL:AAD45155.1 xref: EMBL:AAH10047.2 xref: EMBL:AAH29874.1 xref: EMBL:AAH66895.1 xref: UniProtKB:O75926 xref: UniProtKB:Q8N2W9 xref: UniProtKB:Q96G19 xref: UniProtKB:Q9UN16 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005312 ! PIAS4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006174 ! bard1-pias4 physical interaction relationship: participates_in CCO:I0006806 ! tp53-pias4-3 physical interaction relationship: participates_in CCO:I0007027 ! tp53-pias4-2 physical interaction [Term] id: CCO:B0005403 name: K1377_HUMAN def: "Uncharacterized protein KIAA1377" [UniProtKB:Q9P2H0] xref: EMBL:BAA92615.1 xref: UniProtKB:Q4G0U6 xref: UniProtKB:Q9P2H0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004918 ! KIAA1377_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006175 ! bard1-kiaa1377-1 physical interaction relationship: participates_in CCO:I0006188 ! kiaa1377-kpna2 physical interaction relationship: participates_in CCO:I0007080 ! bard1-kiaa1377 physical interaction relationship: participates_in CCO:I0008016 ! kif15-kiaa1377 physical interaction relationship: participates_in CCO:I0008081 ! cdkn2b-kiaa1377 physical interaction relationship: participates_in CCO:I0008095 ! dleu1-kiaa1377 physical interaction relationship: participates_in CCO:I0008145 ! pfdn1-kiaa1377 physical interaction relationship: participates_in CCO:I0008170 ! supt5h-kiaa1377 physical interaction relationship: participates_in CCO:I0008260 ! mad2l1bp-kiaa1377 physical interaction relationship: participates_in CCO:I0008296 ! pold1-kiaa1377 physical interaction relationship: participates_in CCO:I0008307 ! ran-kiaa1377 physical interaction relationship: participates_in CCO:I0008342 ! pbk-kiaa1377 physical interaction relationship: participates_in CCO:I0008420 ! pmf1-kiaa1377 physical interaction relationship: participates_in CCO:I0008432 ! ruvbl1-kiaa1377 physical interaction [Term] id: CCO:B0005404 name: SETB1_HUMAN def: "Histone-lysine N-methyltransferase SETDB1" [UniProtKB:Q15047] synonym: "EC 2.1.1.43" EXACT [UniProtKB:Q15047] synonym: "ERG-associated protein with SET domain" EXACT [UniProtKB:Q15047] synonym: "ESET" EXACT [UniProtKB:Q15047] synonym: "H3-K9-HMTase 4" EXACT [UniProtKB:Q15047] synonym: "Histone H3-K9 methyltransferase 4" EXACT [UniProtKB:Q15047] synonym: "Lysine N-methyltransferase 1E" EXACT [UniProtKB:Q15047] synonym: "SET domain bifurcated 1" EXACT [UniProtKB:Q15047] xref: EMBL:AAH09362.1 xref: EMBL:AAH28671.1 xref: EMBL:BAA06689.2 xref: EMBL:CAI13325.1 xref: EMBL:CAI13326.1 xref: EMBL:CAI13327.1 xref: EMBL:CAI13328.1 xref: UniProtKB:Q15047 xref: UniProtKB:Q5SZD8 xref: UniProtKB:Q5SZD9 xref: UniProtKB:Q5SZE0 xref: UniProtKB:Q5SZE7 xref: UniProtKB:Q96GM9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005597 ! SETDB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006176 ! bard1-setdb1 physical interaction relationship: participates_in CCO:I0008080 ! cdk4-setdb1 physical interaction relationship: participates_in CCO:I0008112 ! gps2-setdb1 physical interaction relationship: participates_in CCO:I0008133 ! mad2l1bp-setdb1 physical interaction relationship: participates_in CCO:I0008220 ! dleu1-setdb1 physical interaction relationship: participates_in CCO:I0008242 ! smpd3-setdb1 physical interaction relationship: transforms_into CCO:B0014020 ! SETB1_HUMAN-Phosphothreonine838 relationship: transforms_into CCO:B0014021 ! SETB1_HUMAN-Phosphoserine1179 relationship: transforms_into CCO:B0014022 ! SETB1_HUMAN-Phosphothreonine1180 relationship: transforms_into CCO:B0014023 ! SETB1_HUMAN-Phosphoserine1190 [Term] id: CCO:B0005405 name: GASP2_HUMAN def: "G-protein coupled receptor-associated sorting protein 2" [UniProtKB:Q96D09] synonym: "GASP-2" EXACT [UniProtKB:Q96D09] xref: EMBL:AAH13576.1 xref: EMBL:AAH36772.1 xref: EMBL:BAC04010.1 xref: EMBL:CAI43060.1 xref: UniProtKB:Q8NAB4 xref: UniProtKB:Q96D09 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004685 ! GPRASP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006178 ! bard1-gprasp2 physical interaction [Term] id: CCO:B0005406 name: MAGH1_HUMAN def: "Melanoma-associated antigen H1" [UniProtKB:Q9H213] synonym: "Apoptosis-related protein 1" EXACT [UniProtKB:Q9H213] synonym: "APR-1" EXACT [UniProtKB:Q9H213] synonym: "MAGE-H1 antigen" EXACT [UniProtKB:Q9H213] synonym: "Restin" EXACT [UniProtKB:Q9H213] xref: EMBL:AAD31314.4 xref: EMBL:AAG38608.1 xref: EMBL:AAH11954.1 xref: EMBL:CAI41100.1 xref: UniProtKB:Q5JRJ3 xref: UniProtKB:Q9H213 xref: UniProtKB:Q9Y5M2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005021 ! MAGEH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006187 ! mageh1-kpna2 physical interaction [Term] id: CCO:B0005407 name: HD_HUMAN def: "Huntingtin" [UniProtKB:P42858] synonym: "HD protein" EXACT [UniProtKB:P42858] synonym: "Huntington disease protein" EXACT [UniProtKB:P42858] xref: EMBL:AAA52702.1 xref: EMBL:AAB38240.1 xref: EMBL:BAA36753.1 xref: EMBL:CAA89024.1 xref: EMBL:CAA89025.1 xref: EMBL:CAA89839.1 xref: UniProtKB:P42858 xref: UniProtKB:Q9UQB7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0013377 ! HTT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006183 ! hd-mtss1 physical interaction relationship: participates_in CCO:I0006184 ! hd-mtss1-1 physical interaction relationship: participates_in CCO:I0006185 ! hd-mtss1-2 physical interaction relationship: participates_in CCO:I0007241 ! hd-p53-2 physical interaction relationship: participates_in CCO:I0007737 ! hd-p53-3 physical interaction relationship: participates_in CCO:I0007738 ! hd-p53-4 physical interaction relationship: participates_in CCO:I0007849 ! hd-p53-1 physical interaction relationship: transforms_into CCO:B0012175 ! HD_HUMAN-Phosphoserine421 relationship: transforms_into CCO:B0012176 ! HD_HUMAN-Phosphoserine1876 relationship: transforms_into CCO:B0041143 ! HD_HUMAN-Phosphoserine434 [Term] id: CCO:B0005408 name: Q8NI70_HUMAN def: "OK/SW-CL.16" [UniProtKB:Q8NI70] xref: EMBL:BAB93516.1 xref: UniProtKB:Q8NI70 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006027 ! OK/SW-cl.16_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006186 ! ok/sw_cl_16-kpna2 physical interaction [Term] id: CCO:B0005409 name: IMB1_HUMAN def: "Importin subunit beta-1" [UniProtKB:Q14974] synonym: "Importin 90" EXACT [UniProtKB:Q14974] synonym: "Karyopherin subunit beta-1" EXACT [UniProtKB:Q14974] synonym: "Nuclear factor P97" EXACT [UniProtKB:Q14974] xref: EMBL:AAA82869.1 xref: EMBL:AAC41763.1 xref: EMBL:AAH03572.1 xref: EMBL:AAH24045.1 xref: EMBL:AAH36703.1 xref: UniProtKB:Q14637 xref: UniProtKB:Q14974 xref: UniProtKB:Q96J27 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004889 ! KPNB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006829 ! ran-xpot-1 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0012379 ! IMB1_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0005410 name: KU70_HUMAN def: "ATP-dependent DNA helicase 2 subunit 1" [UniProtKB:P12956] synonym: "70 kDa subunit of Ku antigen" EXACT [UniProtKB:P12956] synonym: "ATP-dependent DNA helicase II 70 kDa subunit" EXACT [UniProtKB:P12956] synonym: "CTC box-binding factor 75 kDa subunit" EXACT [UniProtKB:P12956] synonym: "CTC75" EXACT [UniProtKB:P12956] synonym: "CTCBF" EXACT [UniProtKB:P12956] synonym: "DNA-repair protein XRCC6" EXACT [UniProtKB:P12956] synonym: "Ku70" EXACT [UniProtKB:P12956] synonym: "Lupus Ku autoantigen protein p70" EXACT [UniProtKB:P12956] synonym: "Thyroid-lupus autoantigen" EXACT [UniProtKB:P12956] synonym: "TLAA" EXACT [UniProtKB:P12956] xref: EMBL:AAA36155.1 xref: EMBL:AAA51733.1 xref: EMBL:AAA61177.1 xref: EMBL:AAB22381.1 xref: EMBL:AAH08343.1 xref: EMBL:AAH10034.1 xref: EMBL:AAH12154.1 xref: EMBL:AAH18259.1 xref: EMBL:AAH72449.1 xref: EMBL:AAW34364.1 xref: EMBL:CAB46206.1 xref: EMBL:CAG47015.1 xref: UniProtKB:P12956 xref: UniProtKB:Q6FG89 xref: UniProtKB:Q9UCQ2 xref: UniProtKB:Q9UCQ3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004965 ! XRCC6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007575 ! g22p1-centd2-1 physical interaction relationship: participates_in CCO:I0008239 ! smpd3-g22p1 physical interaction relationship: participates_in CCO:I0008369 ! cdca5-g22p1 physical interaction relationship: participates_in CCO:I0008373 ! centd2-g22p1 physical interaction relationship: participates_in CCO:I0008425 ! rbbp4-g22p1 physical interaction relationship: transforms_into CCO:B0012648 ! KU70_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0012649 ! KU70_HUMAN-Phosphoserine6 relationship: transforms_into CCO:B0012650 ! KU70_HUMAN-Phosphoserine27 relationship: transforms_into CCO:B0012651 ! KU70_HUMAN-Phosphoserine51 relationship: transforms_into CCO:B0012652 ! KU70_HUMAN-Phosphoserine222 [Term] id: CCO:B0005411 name: GA45G_HUMAN def: "Growth arrest and DNA-damage-inducible protein GADD45 gamma" [UniProtKB:O95257] synonym: "Cytokine-responsive protein CR6" EXACT [UniProtKB:O95257] synonym: "DDIT-2" EXACT [UniProtKB:O95257] synonym: "DNA-damage-inducible transcript 2" EXACT [UniProtKB:O95257] xref: EMBL:AAC83329.1 xref: EMBL:AAD28544.1 xref: EMBL:AAF73468.1 xref: EMBL:AAH00465.1 xref: EMBL:AAH19325.1 xref: EMBL:AAK00414.1 xref: EMBL:AAM00007.1 xref: EMBL:AAP35898.1 xref: UniProtKB:O95257 xref: UniProtKB:Q9C076 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004676 ! GADD45G_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007532 ! map3k4-gadd45-3 physical interaction [Term] id: CCO:B0005412 name: TP53B_HUMAN def: "Tumor suppressor p53-binding protein 1" [UniProtKB:Q12888] synonym: "53BP1" EXACT [UniProtKB:Q12888] synonym: "p53-binding protein 1" EXACT [UniProtKB:Q12888] synonym: "p53BP1" EXACT [UniProtKB:Q12888] xref: EMBL:AAA21596.1 xref: EMBL:AAC62018.1 xref: EMBL:AAI12162.1 xref: EMBL:AAW69392.1 xref: EMBL:BAE06107.1 xref: EMBL:CAD97660.1 xref: UniProtKB:Q12888 xref: UniProtKB:Q2M1Z7 xref: UniProtKB:Q4LE46 xref: UniProtKB:Q5FWZ3 xref: UniProtKB:Q7Z3U4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005815 ! TP53BP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006198 ! h2ax-tp53bp1-1 physical interaction relationship: participates_in CCO:I0006960 ! mdc1-atm-1 physical interaction relationship: participates_in CCO:I0007166 ! tp53-tp53bp1-1 direct interaction relationship: participates_in CCO:I0007272 ! nek1-tp53bp1-1 physical interaction relationship: transforms_into CCO:B0014450 ! TP53B_HUMAN-Phosphoserine105 relationship: transforms_into CCO:B0014451 ! TP53B_HUMAN-Phosphoserine294 relationship: transforms_into CCO:B0014452 ! TP53B_HUMAN-Phosphothreonine302 relationship: transforms_into CCO:B0014453 ! TP53B_HUMAN-Phosphoserine316 relationship: transforms_into CCO:B0014454 ! TP53B_HUMAN-Phosphoserine380 relationship: transforms_into CCO:B0014455 ! TP53B_HUMAN-Phosphoserine500 relationship: transforms_into CCO:B0014456 ! TP53B_HUMAN-Phosphoserine523 relationship: transforms_into CCO:B0014457 ! TP53B_HUMAN-Phosphoserine525 relationship: transforms_into CCO:B0014458 ! TP53B_HUMAN-Phosphothreonine543 relationship: transforms_into CCO:B0014459 ! TP53B_HUMAN-Phosphothreonine548 relationship: transforms_into CCO:B0014460 ! TP53B_HUMAN-Phosphoserine552 relationship: transforms_into CCO:B0014461 ! TP53B_HUMAN-Phosphoserine566 relationship: transforms_into CCO:B0014462 ! TP53B_HUMAN-Phosphoserine580 relationship: transforms_into CCO:B0014463 ! TP53B_HUMAN-Phosphoserine625 relationship: transforms_into CCO:B0014464 ! TP53B_HUMAN-Phosphoserine635 relationship: transforms_into CCO:B0014465 ! TP53B_HUMAN-Phosphoserine639 relationship: transforms_into CCO:B0014466 ! TP53B_HUMAN-Phosphoserine640 relationship: transforms_into CCO:B0014467 ! TP53B_HUMAN-Phosphoserine659 relationship: transforms_into CCO:B0014468 ! TP53B_HUMAN-Phosphoserine660 relationship: transforms_into CCO:B0014469 ! TP53B_HUMAN-Phosphoserine662 relationship: transforms_into CCO:B0014470 ! TP53B_HUMAN-Phosphothreonine750 relationship: transforms_into CCO:B0014471 ! TP53B_HUMAN-Phosphoserine751 relationship: transforms_into CCO:B0014472 ! TP53B_HUMAN-Phosphoserine754 relationship: transforms_into CCO:B0014473 ! TP53B_HUMAN-Phosphoserine755 relationship: transforms_into CCO:B0014474 ! TP53B_HUMAN-Phosphoserine771 relationship: transforms_into CCO:B0014475 ! TP53B_HUMAN-Phosphoserine782 relationship: transforms_into CCO:B0014476 ! TP53B_HUMAN-Phosphoserine784 relationship: transforms_into CCO:B0014477 ! TP53B_HUMAN-Phosphoserine831 relationship: transforms_into CCO:B0014478 ! TP53B_HUMAN-Phosphothreonine855 relationship: transforms_into CCO:B0014479 ! TP53B_HUMAN-Phosphoserine892 relationship: transforms_into CCO:B0014480 ! TP53B_HUMAN-Phosphoserine993 relationship: transforms_into CCO:B0014481 ! TP53B_HUMAN-Phosphothreonine996 relationship: transforms_into CCO:B0014482 ! TP53B_HUMAN-Phosphoserine999 relationship: transforms_into CCO:B0014483 ! TP53B_HUMAN-Phosphoserine1002 relationship: transforms_into CCO:B0014484 ! TP53B_HUMAN-Phosphoserine1028 relationship: transforms_into CCO:B0014485 ! TP53B_HUMAN-Phosphothreonine1056 relationship: transforms_into CCO:B0014486 ! TP53B_HUMAN-Phosphoserine1068 relationship: transforms_into CCO:B0014487 ! TP53B_HUMAN-Phosphoserine1094 relationship: transforms_into CCO:B0014488 ! TP53B_HUMAN-Phosphoserine1104 relationship: transforms_into CCO:B0014489 ! TP53B_HUMAN-Phosphoserine1114 relationship: transforms_into CCO:B0014490 ! TP53B_HUMAN-Phosphothreonine1171 relationship: transforms_into CCO:B0014491 ! TP53B_HUMAN-Phosphothreonine1214 relationship: transforms_into CCO:B0014492 ! TP53B_HUMAN-Phosphoserine1216 relationship: transforms_into CCO:B0014493 ! TP53B_HUMAN-Phosphoserine1219 relationship: transforms_into CCO:B0014494 ! TP53B_HUMAN-Phosphoserine1290 relationship: transforms_into CCO:B0014495 ! TP53B_HUMAN-Phosphoserine1316 relationship: transforms_into CCO:B0014496 ! TP53B_HUMAN-Phosphoserine1317 relationship: transforms_into CCO:B0014497 ! TP53B_HUMAN-Phosphoserine1320 relationship: transforms_into CCO:B0014498 ! TP53B_HUMAN-Phosphoserine1362 relationship: transforms_into CCO:B0014499 ! TP53B_HUMAN-Phosphoserine1426 relationship: transforms_into CCO:B0014500 ! TP53B_HUMAN-Phosphoserine1430 relationship: transforms_into CCO:B0014501 ! TP53B_HUMAN-Phosphoserine1631 relationship: transforms_into CCO:B0014502 ! TP53B_HUMAN-Phosphoserine1634 relationship: transforms_into CCO:B0014503 ! TP53B_HUMAN-Phosphoserine1635 relationship: transforms_into CCO:B0014504 ! TP53B_HUMAN-Phosphothreonine1638 relationship: transforms_into CCO:B0014505 ! TP53B_HUMAN-Phosphothreonine1647 relationship: transforms_into CCO:B0014506 ! TP53B_HUMAN-Phosphoserine1673 relationship: transforms_into CCO:B0014507 ! TP53B_HUMAN-Phosphoserine1678 relationship: transforms_into CCO:B0014508 ! TP53B_HUMAN-Phosphoserine1701 relationship: transforms_into CCO:B0014509 ! TP53B_HUMAN-Phosphoserine1705 relationship: transforms_into CCO:B0032859 ! TP53B_HUMAN-Phosphoserine166 relationship: transforms_into CCO:B0032860 ! TP53B_HUMAN-Phosphoserine176 relationship: transforms_into CCO:B0032861 ! TP53B_HUMAN-Phosphoserine178 relationship: transforms_into CCO:B0032862 ! TP53B_HUMAN-Phosphoserine452 [Term] id: CCO:B0005413 name: 1433Z_HUMAN def: "14-3-3 protein zeta/delta" [UniProtKB:P63104] synonym: "KCIP-1" EXACT [UniProtKB:P63104] synonym: "Protein kinase C inhibitor protein 1" EXACT [UniProtKB:P63104] xref: EMBL:AAA36446.1 xref: EMBL:AAC52052.1 xref: EMBL:AAH03623.3 xref: EMBL:AAH51814.1 xref: EMBL:AAH63824.2 xref: EMBL:AAH68456.2 xref: EMBL:AAH72426.2 xref: EMBL:AAH73141.1 xref: EMBL:AAH83508.2 xref: EMBL:AAH99904.1 xref: EMBL:AAI01484.1 xref: EMBL:AAI08282.1 xref: EMBL:AAI11952.1 xref: UniProtKB:P29213 xref: UniProtKB:P29312 xref: UniProtKB:P63104 xref: UniProtKB:Q32P43 xref: UniProtKB:Q5XJ08 xref: UniProtKB:Q6GPI2 xref: UniProtKB:Q6IN74 xref: UniProtKB:Q6NUR9 xref: UniProtKB:Q6P3U9 xref: UniProtKB:Q86V33 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0003998 ! YWHAZ_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006203 ! abl1-ywhaz-1 physical interaction relationship: participates_in CCO:I0006258 ! qsk-ywhaz-3 physical interaction relationship: participates_in CCO:I0006282 ! ywhaz-egfr-1 physical interaction relationship: participates_in CCO:I0006307 ! abl1-ywhab-1 physical interaction relationship: participates_in CCO:I0006605 ! cdc5l-ywhaz physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007180 ! snf1lk-ywhaz-1 physical interaction relationship: participates_in CCO:I0007183 ! snf1lk-ywhaz-2 direct interaction relationship: participates_in CCO:I0007212 ! ywhaz-pard3-1 physical interaction relationship: participates_in CCO:I0007214 ! pard6a-ywhaz-1 physical interaction relationship: participates_in CCO:I0007216 ! pard6b-ywhaz-1 physical interaction relationship: participates_in CCO:I0007218 ! pard3-ywhaz-1 physical interaction relationship: participates_in CCO:I0007837 ! qsk-ywhaz-2 physical interaction relationship: participates_in CCO:I0007845 ! ywhaz-egfr-2 colocalization relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0010373 ! 1433Z_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0010374 ! 1433Z_HUMAN-Phosphoserine184 relationship: transforms_into CCO:B0010375 ! 1433Z_HUMAN-Phosphothreonine232 [Term] id: CCO:B0005414 name: SMCA4_HUMAN def: "Probable global transcription activator SNF2L4" [UniProtKB:P51532] synonym: "ATP-dependent helicase SMARCA4" EXACT [UniProtKB:P51532] synonym: "Brahma protein homolog 1" EXACT [UniProtKB:P51532] synonym: "BRG-1 protein" EXACT [UniProtKB:P51532] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P51532] synonym: "Mitotic growth and transcription activator" EXACT [UniProtKB:P51532] synonym: "SNF2-beta" EXACT [UniProtKB:P51532] synonym: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4" EXACT [UniProtKB:P51532] xref: EMBL:AAB40977.1 xref: EMBL:AAC97986.1 xref: EMBL:AAC97987.1 xref: EMBL:AAG24789.1 xref: EMBL:BAA05143.1 xref: UniProtKB:O95052 xref: UniProtKB:P51532 xref: UniProtKB:Q9HBD3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005631 ! SMARCA4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006205 ! smarca4-pb1-arid2-1 physical interaction relationship: participates_in CCO:I0006322 ! pb1-arid2-4 physical interaction relationship: participates_in CCO:I0006977 ! smarca4-pb1-arid2-2 physical interaction relationship: participates_in CCO:I0007260 ! brg1-baf250a-1 physical interaction relationship: participates_in CCO:I0007356 ! pb1-arid2-3 physical interaction relationship: participates_in CCO:I0007569 ! brg1-baf200-2 physical interaction relationship: participates_in CCO:I0007756 ! brg1-baf250a-2 physical interaction relationship: participates_in CCO:I0007876 ! brg1-baf200-1 physical interaction relationship: transforms_into CCO:B0014098 ! SMCA4_HUMAN-Phosphothreonine11 relationship: transforms_into CCO:B0014099 ! SMCA4_HUMAN-Phosphoserine610 relationship: transforms_into CCO:B0014100 ! SMCA4_HUMAN-Phosphoserine655 relationship: transforms_into CCO:B0014101 ! SMCA4_HUMAN-Phosphoserine657 relationship: transforms_into CCO:B0014102 ! SMCA4_HUMAN-Phosphoserine660 relationship: transforms_into CCO:B0014103 ! SMCA4_HUMAN-Phosphoserine662 relationship: transforms_into CCO:B0014104 ! SMCA4_HUMAN-Phosphoserine695 relationship: transforms_into CCO:B0014105 ! SMCA4_HUMAN-Phosphoserine721 relationship: transforms_into CCO:B0014106 ! SMCA4_HUMAN-Phosphoserine1382 relationship: transforms_into CCO:B0014107 ! SMCA4_HUMAN-Phosphoserine1452 [Term] id: CCO:B0005415 name: SMRD1_HUMAN def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1" [UniProtKB:Q96GM5] synonym: "60 kDa BRG-1/Brm-associated factor subunit A" EXACT [UniProtKB:Q96GM5] synonym: "BRG1-associated factor 60A" EXACT [UniProtKB:Q96GM5] synonym: "SWI/SNF complex 60 kDa subunit" EXACT [UniProtKB:Q96GM5] xref: EMBL:AAC50695.1 xref: EMBL:AAD23390.1 xref: EMBL:AAH09368.3 xref: UniProtKB:Q92924 xref: UniProtKB:Q96GM5 xref: UniProtKB:Q9Y635 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005638 ! SMARCD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006205 ! smarca4-pb1-arid2-1 physical interaction relationship: participates_in CCO:I0006977 ! smarca4-pb1-arid2-2 physical interaction [Term] id: CCO:B0005416 name: SMCE1_HUMAN def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1" [UniProtKB:Q969G3] synonym: "BRG1-associated factor 57" EXACT [UniProtKB:Q969G3] xref: EMBL:AAC04509.1 xref: EMBL:AAH07082.1 xref: EMBL:AAH11017.1 xref: EMBL:AAH63700.1 xref: EMBL:AAP35840.1 xref: UniProtKB:O43539 xref: UniProtKB:Q969G3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005632 ! SMARCE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006205 ! smarca4-pb1-arid2-1 physical interaction relationship: participates_in CCO:I0006938 ! brms1-smarce1 physical interaction relationship: participates_in CCO:I0006977 ! smarca4-pb1-arid2-2 physical interaction relationship: participates_in CCO:I0007356 ! pb1-arid2-3 physical interaction relationship: participates_in CCO:I0007722 ! smarce1-brms1 physical interaction [Term] id: CCO:B0005417 name: SMRC2_HUMAN def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2" [UniProtKB:Q8TAQ2] synonym: "BRG1-associated factor 170" EXACT [UniProtKB:Q8TAQ2] synonym: "SWI/SNF complex 170 kDa subunit" EXACT [UniProtKB:Q8TAQ2] xref: EMBL:AAC50694.1 xref: EMBL:AAH09067.1 xref: EMBL:AAH13045.1 xref: EMBL:AAH26222.1 xref: EMBL:AAP88926.1 xref: UniProtKB:Q8TAQ2 xref: UniProtKB:Q92923 xref: UniProtKB:Q96E12 xref: UniProtKB:Q96GY4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005637 ! SMARCC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006205 ! smarca4-pb1-arid2-1 physical interaction relationship: participates_in CCO:I0006977 ! smarca4-pb1-arid2-2 physical interaction relationship: transforms_into CCO:B0014120 ! SMRC2_HUMAN-Phosphoserine283 relationship: transforms_into CCO:B0014121 ! SMRC2_HUMAN-Phosphotyrosine296 relationship: transforms_into CCO:B0014122 ! SMRC2_HUMAN-Phosphoserine302 relationship: transforms_into CCO:B0014123 ! SMRC2_HUMAN-Phosphoserine304 relationship: transforms_into CCO:B0014124 ! SMRC2_HUMAN-Phosphothreonine322 relationship: transforms_into CCO:B0014125 ! SMRC2_HUMAN-Phosphoserine347 relationship: transforms_into CCO:B0036031 ! SMRC2_HUMAN-Phosphoserine806 [Term] id: CCO:B0005418 name: SMRC1_HUMAN def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1" [UniProtKB:Q92922] synonym: "BRG1-associated factor 155" EXACT [UniProtKB:Q92922] synonym: "SWI/SNF complex 155 kDa subunit" EXACT [UniProtKB:Q92922] xref: EMBL:AAC50693.1 xref: EMBL:AAH39843.1 xref: EMBL:AAH65253.1 xref: UniProtKB:Q6P172 xref: UniProtKB:Q8IWH2 xref: UniProtKB:Q92922 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005636 ! SMARCC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006205 ! smarca4-pb1-arid2-1 physical interaction relationship: transforms_into CCO:B0014113 ! SMRC1_HUMAN-Phosphoserine310 relationship: transforms_into CCO:B0014114 ! SMRC1_HUMAN-Phosphoserine319 relationship: transforms_into CCO:B0014115 ! SMRC1_HUMAN-Phosphoserine328 relationship: transforms_into CCO:B0014116 ! SMRC1_HUMAN-Phosphoserine330 relationship: transforms_into CCO:B0014117 ! SMRC1_HUMAN-Phosphothreonine335 relationship: transforms_into CCO:B0014118 ! SMRC1_HUMAN-Phosphothreonine337 relationship: transforms_into CCO:B0014119 ! SMRC1_HUMAN-Phosphoserine357 [Term] id: CCO:B0005419 name: SMRD2_HUMAN def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2" [UniProtKB:Q92925] synonym: "60 kDa BRG-1/Brm-associated factor subunit B" EXACT [UniProtKB:Q92925] synonym: "BRG1-associated factor 60B" EXACT [UniProtKB:Q92925] xref: EMBL:AAC50696.1 xref: EMBL:AAF20280.1 xref: EMBL:AAH18953.2 xref: UniProtKB:Q7L2I6 xref: UniProtKB:Q92925 xref: UniProtKB:Q9UHZ1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005639 ! SMARCD2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006205 ! smarca4-pb1-arid2-1 physical interaction relationship: transforms_into CCO:B0014126 ! SMRD2_HUMAN-Phosphothreonine142 relationship: transforms_into CCO:B0014127 ! SMRD2_HUMAN-Phosphothreonine408 [Term] id: CCO:B0005420 name: BAK_HUMAN def: "Bcl-2 homologous antagonist/killer" [UniProtKB:Q16611] synonym: "Apoptosis regulator BAK" EXACT [UniProtKB:Q16611] synonym: "Bcl-2-like 7 protein" EXACT [UniProtKB:Q16611] xref: EMBL:AAA74466.1 xref: EMBL:AAA93066.1 xref: EMBL:AAH04431.1 xref: EMBL:AAO74828.1 xref: EMBL:BAA13606.1 xref: EMBL:CAA58997.1 xref: EMBL:CAB65626.1 xref: UniProtKB:Q16611 xref: UniProtKB:Q92533 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004135 ! BAK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007764 ! bak-bax-1 physical interaction [Term] id: CCO:B0005423 name: DNM3B_HUMAN def: "DNA (cytosine-5)-methyltransferase 3B" [UniProtKB:Q9UBC3] synonym: "DNA methyltransferase HsaIIIB" EXACT [UniProtKB:Q9UBC3] synonym: "DNA MTase HsaIIIB" EXACT [UniProtKB:Q9UBC3] synonym: "Dnmt3b" EXACT [UniProtKB:Q9UBC3] synonym: "EC 2.1.1.37" EXACT [UniProtKB:Q9UBC3] synonym: "M.HsaIIIB" EXACT [UniProtKB:Q9UBC3] xref: EMBL:AAD31432.1 xref: EMBL:AAD31433.1 xref: EMBL:AAD31434.1 xref: EMBL:AAD53062.1 xref: EMBL:AAD53063.1 xref: EMBL:AAF04015.1 xref: EMBL:AAL57040.1 xref: EMBL:CAB53069.1 xref: EMBL:CAB53070.1 xref: EMBL:CAB53071.1 xref: UniProtKB:Q9UBC3 xref: UniProtKB:Q9UBD4 xref: UniProtKB:Q9UJQ5 xref: UniProtKB:Q9UKA6 xref: UniProtKB:Q9UNE5 xref: UniProtKB:Q9Y5R9 xref: UniProtKB:Q9Y5S0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004495 ! DNMT3B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006213 ! dnmt3b-ube2i-2 physical interaction relationship: participates_in CCO:I0006630 ! dnmt3b-ubl1-ube2i-1 physical interaction relationship: participates_in CCO:I0007287 ! dnmt3b-ube2i-1 physical interaction [Term] id: CCO:B0005424 name: EP15_HUMAN def: "Epidermal growth factor receptor substrate 15" [UniProtKB:P42566] synonym: "AF-1p protein" EXACT [UniProtKB:P42566] synonym: "Protein Eps15" EXACT [UniProtKB:P42566] xref: EMBL:AAA52101.1 xref: EMBL:ABD34786.1 xref: EMBL:CAA82305.1 xref: EMBL:CAI13030.1 xref: UniProtKB:P42566 xref: UniProtKB:Q5SRH4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004567 ! EPS15_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006214 ! rabgef1-egfr physical interaction relationship: transforms_into CCO:B0011696 ! EP15_HUMAN-Phosphoserine323 relationship: transforms_into CCO:B0011697 ! EP15_HUMAN-Phosphoserine324 relationship: transforms_into CCO:B0011698 ! EP15_HUMAN-Phosphoserine485 relationship: transforms_into CCO:B0011699 ! EP15_HUMAN-Phosphoserine562 relationship: transforms_into CCO:B0011700 ! EP15_HUMAN-Phosphoserine563 relationship: transforms_into CCO:B0011701 ! EP15_HUMAN-Phosphothreonine779 relationship: transforms_into CCO:B0011702 ! EP15_HUMAN-Phosphoserine814 relationship: transforms_into CCO:B0011703 ! EP15_HUMAN-Phosphotyrosine849 relationship: transforms_into CCO:B0041135 ! EP15_HUMAN-Phosphothreonine777 relationship: transforms_into CCO:B0041136 ! EP15_HUMAN-Phosphoserine796 [Term] id: CCO:B0005425 name: ATX1_HUMAN def: "Ataxin-1" [UniProtKB:P54253] synonym: "Spinocerebellar ataxia type 1 protein" EXACT [UniProtKB:P54253] xref: EMBL:AAD14401.1 xref: EMBL:CAA15622.1 xref: EMBL:CAA55793.1 xref: UniProtKB:P54253 xref: UniProtKB:Q9UJG2 xref: UniProtKB:Q9Y4J1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004126 ! ATXN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006215 ! atxn1-ccnk physical interaction relationship: participates_in CCO:I0006645 ! ccnk-atxn1 physical interaction relationship: participates_in CCO:I0006646 ! cdk6-atxn1 physical interaction relationship: participates_in CCO:I0006647 ! pim2-atxn1 physical interaction relationship: participates_in CCO:I0007619 ! atxn1-btg3 physical interaction relationship: participates_in CCO:I0007620 ! atxn1-apbb1 physical interaction relationship: participates_in CCO:I0007621 ! atxn1-apbb1-1 physical interaction relationship: participates_in CCO:I0007622 ! atxn1-ube2i physical interaction relationship: participates_in CCO:I0007623 ! atxn1-btg3-1 physical interaction relationship: participates_in CCO:I0007624 ! atxn1-dctn3 physical interaction relationship: participates_in CCO:I0007625 ! atxn1-gspt1 physical interaction relationship: participates_in CCO:I0008785 ! atxn1-psmc3 physical interaction [Term] id: CCO:B0005426 name: CENPJ_HUMAN def: "Centromere protein J" [UniProtKB:Q9HC77] synonym: "CENP-J" EXACT [UniProtKB:Q9HC77] synonym: "Centrosomal P4.1-associated protein" EXACT [UniProtKB:Q9HC77] synonym: "LAG-3-associated protein" EXACT [UniProtKB:Q9HC77] synonym: "LYST-interacting protein 1" EXACT [UniProtKB:Q9HC77] xref: EMBL:AAG21074.1 xref: EMBL:AAG49440.1 xref: EMBL:AAH24209.3 xref: EMBL:AAI13111.1 xref: EMBL:AAI13663.1 xref: EMBL:AAI13665.1 xref: EMBL:CAC80028.1 xref: EMBL:CAI16635.1 xref: UniProtKB:Q2KHM6 xref: UniProtKB:Q5T6R5 xref: UniProtKB:Q96KS5 xref: UniProtKB:Q9C067 xref: UniProtKB:Q9HC77 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004327 ! CENPJ_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006216 ! cenpj-gfi1b physical interaction relationship: participates_in CCO:I0007637 ! gfi1b-cenpj physical interaction relationship: transforms_into CCO:B0011176 ! CENPJ_HUMAN-Phosphoserine1109 [Term] id: CCO:B0005427 name: NELL2_HUMAN def: "Protein kinase C-binding protein NELL2 precursor" [UniProtKB:Q99435] synonym: "NEL-like protein 2" EXACT [UniProtKB:Q99435] synonym: "Nel-related protein 2" EXACT [UniProtKB:Q99435] xref: EMBL:AAH20544.1 xref: EMBL:BAA11681.1 xref: UniProtKB:Q99435 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005182 ! NELL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006218 ! gfi1b-nell2 physical interaction relationship: participates_in CCO:I0007665 ! gfi1b-nell2-1 physical interaction [Term] id: CCO:B0005428 name: CSK21_HUMAN def: "Casein kinase II subunit alpha" [UniProtKB:P68400] synonym: "CK II" EXACT [UniProtKB:P68400] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P68400] xref: EMBL:AAA35503.1 xref: EMBL:AAA56821.1 xref: EMBL:AAH11668.1 xref: EMBL:AAH53532.1 xref: EMBL:AAH71167.1 xref: EMBL:CAA49758.1 xref: EMBL:CAB65624.1 xref: UniProtKB:P19138 xref: UniProtKB:P20426 xref: UniProtKB:P68400 xref: UniProtKB:Q14013 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004402 ! CSNK2A1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006220 ! csnk2a1-pml-1 phosphorylation relationship: participates_in CCO:I0007379 ! csnk2a1-pml phosphorylation [Term] id: CCO:B0005429 name: UBP7_HUMAN def: "Ubiquitin carboxyl-terminal hydrolase 7" [UniProtKB:Q93009] synonym: "Deubiquitinating enzyme 7" EXACT [UniProtKB:Q93009] synonym: "EC 3.1.2.15" EXACT [UniProtKB:Q93009] synonym: "Herpesvirus-associated ubiquitin-specific protease" EXACT [UniProtKB:Q93009] synonym: "Ubiquitin thioesterase 7" EXACT [UniProtKB:Q93009] synonym: "Ubiquitin-specific-processing protease 7" EXACT [UniProtKB:Q93009] xref: EMBL:CAA96580.1 xref: UniProtKB:Q93009 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005871 ! USP7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006763 ! usp7-tp53-5 physical interaction relationship: participates_in CCO:I0007381 ! ubp7-daxx-6 physical interaction relationship: participates_in CCO:I0007384 ! usp7-tp53 physical interaction relationship: participates_in CCO:I0007385 ! usp7-tp53-1 physical interaction relationship: participates_in CCO:I0007386 ! usp7-tp53-2 physical interaction relationship: participates_in CCO:I0007461 ! usp7-tp53-3 direct interaction relationship: participates_in CCO:I0007808 ! ubp7-daxx-7 physical interaction relationship: participates_in CCO:I0007810 ! ubp7-daxx-9 physical interaction relationship: participates_in CCO:I0007931 ! usp7-tp53-4 physical interaction relationship: transforms_into CCO:B0014570 ! UBP7_HUMAN-Phosphoserine18 [Term] id: CCO:B0005430 name: HIF1A_HUMAN def: "Hypoxia-inducible factor 1 alpha" [UniProtKB:Q16665] synonym: "ARNT-interacting protein" EXACT [UniProtKB:Q16665] synonym: "Basic-helix-loop-helix-PAS protein MOP1" EXACT [UniProtKB:Q16665] synonym: "HIF-1 alpha" EXACT [UniProtKB:Q16665] synonym: "HIF1 alpha" EXACT [UniProtKB:Q16665] synonym: "Member of PAS protein 1" EXACT [UniProtKB:Q16665] xref: EMBL:AAC50152.1 xref: EMBL:AAC51210.1 xref: EMBL:AAC68568.1 xref: EMBL:AAF20139.1 xref: EMBL:AAF20140.1 xref: EMBL:AAF20149.1 xref: EMBL:AAG43026.1 xref: EMBL:AAH12527.1 xref: EMBL:AAP88778.1 xref: EMBL:BAB70608.1 xref: UniProtKB:Q16665 xref: UniProtKB:Q53XP6 xref: UniProtKB:Q96PT9 xref: UniProtKB:Q9UPB1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004806 ! HIF1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006223 ! pcaf-hif1a physical interaction relationship: participates_in CCO:I0006352 ! pcaf-hif1a-1 physical interaction relationship: participates_in CCO:I0006702 ! hif1a-ep300-3 physical interaction relationship: participates_in CCO:I0006820 ! hif1a-vhl-1 physical interaction relationship: participates_in CCO:I0007175 ! hif1a-os9-4 direct interaction relationship: participates_in CCO:I0007176 ! hif1a-vhl physical interaction relationship: participates_in CCO:I0007529 ! hif1a-ep300-2 physical interaction relationship: participates_in CCO:I0007954 ! hif1a-ep300-1 physical interaction relationship: transforms_into CCO:B0012191 ! HIF1A_HUMAN-4-hydroxyproline402 relationship: transforms_into CCO:B0012192 ! HIF1A_HUMAN-N6-acetyllysine532 relationship: transforms_into CCO:B0012193 ! HIF1A_HUMAN-4-hydroxyproline564 relationship: transforms_into CCO:B0012194 ! HIF1A_HUMAN-S-nitrosocysteine800 relationship: transforms_into CCO:B0012195 ! HIF1A_HUMAN-3-hydroxyasparagine803 [Term] id: CCO:B0005431 name: CENPB_HUMAN def: "Major centromere autoantigen B" [UniProtKB:P07199] synonym: "CENP-B" EXACT [UniProtKB:P07199] synonym: "Centromere protein B" EXACT [UniProtKB:P07199] xref: EMBL:AAH53847.1 xref: EMBL:CAA28918.1 xref: EMBL:CAA38879.1 xref: EMBL:CAC17547.1 xref: UniProtKB:P07199 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004322 ! CENPB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006225 ! cdca1_cenpb_1 colocalization relationship: participates_in CCO:I0006226 ! kntc2_cenpb_1 colocalization relationship: participates_in CCO:I0007636 ! gfi1b-cenpb physical interaction relationship: transforms_into CCO:B0011135 ! CENPB_HUMAN-Phosphoserine156 relationship: transforms_into CCO:B0011136 ! CENPB_HUMAN-Phosphoserine165 [Term] id: CCO:B0005432 name: DCP1A_HUMAN def: "mRNA-decapping enzyme 1A" [UniProtKB:Q9NPI6] synonym: "EC 3.-.-.-" EXACT [UniProtKB:Q9NPI6] synonym: "Smad4-interacting transcriptional co-activator" EXACT [UniProtKB:Q9NPI6] synonym: "Transcription factor SMIF" EXACT [UniProtKB:Q9NPI6] xref: EMBL:AAH07439.1 xref: EMBL:AAN62763.1 xref: EMBL:BAA92008.1 xref: EMBL:CAB77023.1 xref: UniProtKB:Q9NPI6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004444 ! DCP1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006228 ! rent1-dcp2 physical interaction relationship: participates_in CCO:I0006229 ! dcp1a-upf1 physical interaction relationship: participates_in CCO:I0006231 ! upf1-dcp1a-2 physical interaction relationship: participates_in CCO:I0006239 ! upf1-dcp1a-3 physical interaction relationship: participates_in CCO:I0006240 ! upf1-dcp1a-4 physical interaction relationship: participates_in CCO:I0006241 ! upf1-dcp1a-5 physical interaction relationship: participates_in CCO:I0006911 ! dcp1a-rcd8-xrn1 colocalization relationship: participates_in CCO:I0007014 ! upf1-dcp1a physical interaction relationship: participates_in CCO:I0007016 ! upf1-rcd8 physical interaction relationship: transforms_into CCO:B0011442 ! DCP1A_HUMAN-Phosphoserine353 relationship: transforms_into CCO:B0011443 ! DCP1A_HUMAN-Phosphoserine523 relationship: transforms_into CCO:B0011444 ! DCP1A_HUMAN-Phosphoserine525 [Term] id: CCO:B0005433 name: DCP2_HUMAN def: "mRNA-decapping enzyme 2" [UniProtKB:Q8IU60] synonym: "EC 3.-.-.-" EXACT [UniProtKB:Q8IU60] synonym: "hDpc" EXACT [UniProtKB:Q8IU60] synonym: "Nucleoside diphosphate-linked moiety X motif 20" EXACT [UniProtKB:Q8IU60] synonym: "Nudix motif 20" EXACT [UniProtKB:Q8IU60] xref: EMBL:AAH45596.1 xref: EMBL:AAH64593.1 xref: EMBL:AAN08884.1 xref: EMBL:AAN62762.1 xref: EMBL:BAC03479.1 xref: UniProtKB:Q6P2D4 xref: UniProtKB:Q7Z5W5 xref: UniProtKB:Q8IU60 xref: UniProtKB:Q8NBG5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004445 ! DCP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006228 ! rent1-dcp2 physical interaction relationship: participates_in CCO:I0006230 ! dcp2-upf physical interaction relationship: participates_in CCO:I0007015 ! upf1-dcp2 physical interaction relationship: transforms_into CCO:B0011445 ! DCP2_HUMAN-Phosphoserine246 relationship: transforms_into CCO:B0011446 ! DCP2_HUMAN-Phosphoserine247 relationship: transforms_into CCO:B0011447 ! DCP2_HUMAN-Phosphoserine249 relationship: transforms_into CCO:B0011448 ! DCP2_HUMAN-Phosphoserine276 relationship: transforms_into CCO:B0011449 ! DCP2_HUMAN-Phosphoserine284 relationship: transforms_into CCO:B0011450 ! DCP2_HUMAN-Phosphoserine347 [Term] id: CCO:B0005434 name: REN3B_HUMAN def: "Regulator of nonsense transcripts 3B" [UniProtKB:Q9BZI7] synonym: "hUpf3B" EXACT [UniProtKB:Q9BZI7] synonym: "hUpf3p-X" EXACT [UniProtKB:Q9BZI7] synonym: "Nonsense mRNA reducing factor 3B" EXACT [UniProtKB:Q9BZI7] synonym: "Up-frameshift suppressor 3 homolog B" EXACT [UniProtKB:Q9BZI7] xref: EMBL:AAG48511.1 xref: EMBL:AAG60691.1 xref: EMBL:AAI21018.1 xref: UniProtKB:Q0VAK8 xref: UniProtKB:Q9BZI7 xref: UniProtKB:Q9H1J0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005466 ! UPF3B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006231 ! upf1-dcp1a-2 physical interaction relationship: participates_in CCO:I0006239 ! upf1-dcp1a-3 physical interaction relationship: participates_in CCO:I0006240 ! upf1-dcp1a-4 physical interaction relationship: participates_in CCO:I0007249 ! rent1-stau-6 physical interaction [Term] id: CCO:B0005435 name: RENT2_HUMAN def: "Regulator of nonsense transcripts 2" [UniProtKB:Q9HAU5] synonym: "hUpf2" EXACT [UniProtKB:Q9HAU5] synonym: "Nonsense mRNA reducing factor 2" EXACT [UniProtKB:Q9HAU5] synonym: "Up-frameshift suppressor 2 homolog" EXACT [UniProtKB:Q9HAU5] xref: EMBL:AAG33225.1 xref: EMBL:AAG48509.1 xref: EMBL:AAG60689.1 xref: EMBL:AAI14965.1 xref: EMBL:AAI15738.1 xref: EMBL:BAA91369.1 xref: EMBL:BAA92646.1 xref: EMBL:BAC04721.1 xref: EMBL:CAB45771.1 xref: EMBL:CAH73458.1 xref: EMBL:CAH73459.1 xref: EMBL:CAI16755.1 xref: EMBL:CAI16756.1 xref: UniProtKB:A6NLJ5 xref: UniProtKB:Q14BM1 xref: UniProtKB:Q5W0J4 xref: UniProtKB:Q8N8U1 xref: UniProtKB:Q9H1J2 xref: UniProtKB:Q9HAU5 xref: UniProtKB:Q9NWL1 xref: UniProtKB:Q9P2D9 xref: UniProtKB:Q9Y4M9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005468 ! UPF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006231 ! upf1-dcp1a-2 physical interaction relationship: participates_in CCO:I0006239 ! upf1-dcp1a-3 physical interaction relationship: participates_in CCO:I0007249 ! rent1-stau-6 physical interaction [Term] id: CCO:B0005436 name: REN3A_HUMAN def: "Regulator of nonsense transcripts 3A" [UniProtKB:Q9H1J1] synonym: "hUpf3" EXACT [UniProtKB:Q9H1J1] synonym: "Nonsense mRNA reducing factor 3A" EXACT [UniProtKB:Q9H1J1] synonym: "Up-frameshift suppressor 3 homolog A" EXACT [UniProtKB:Q9H1J1] xref: EMBL:AAG48510.1 xref: EMBL:AAG60690.1 xref: EMBL:AAH08694.1 xref: EMBL:AAH23569.1 xref: UniProtKB:Q5T8C3 xref: UniProtKB:Q5T8C9 xref: UniProtKB:Q7Z6N3 xref: UniProtKB:Q86YK1 xref: UniProtKB:Q9BZI8 xref: UniProtKB:Q9H1J1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005465 ! UPF3A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006231 ! upf1-dcp1a-2 physical interaction relationship: participates_in CCO:I0006239 ! upf1-dcp1a-3 physical interaction relationship: participates_in CCO:I0006240 ! upf1-dcp1a-4 physical interaction relationship: transforms_into CCO:B0036027 ! REN3A_HUMAN-Phosphoserine68 [Term] id: CCO:B0005437 name: BMR1A_HUMAN def: "Bone morphogenetic protein receptor type-1A precursor" [UniProtKB:P36894] synonym: "Activin receptor-like kinase 3" EXACT [UniProtKB:P36894] synonym: "ALK-3" EXACT [UniProtKB:P36894] synonym: "CD292 antigen" EXACT [UniProtKB:P36894] synonym: "EC 2.7.11.30" EXACT [UniProtKB:P36894] synonym: "Serine/threonine-protein kinase receptor R5" EXACT [UniProtKB:P36894] synonym: "SKR5" EXACT [UniProtKB:P36894] xref: EMBL:AAH28383.1 xref: EMBL:CAA80257.1 xref: UniProtKB:P36894 xref: UniProtKB:Q8NEN8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004174 ! BMPR1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006232 ! bmp2-bmpr1a-1 direct interaction relationship: participates_in CCO:I0007709 ! bmp2-bmpr1a-2 direct interaction relationship: transforms_into CCO:B0010811 ! BMR1A_HUMAN-Phosphoserine215 relationship: transforms_into CCO:B0010812 ! BMR1A_HUMAN-Phosphoserine216 relationship: transforms_into CCO:B0010813 ! BMR1A_HUMAN-Phosphoserine218 relationship: transforms_into CCO:B0010814 ! BMR1A_HUMAN-Phosphoserine220 [Term] id: CCO:B0005438 name: MET_HUMAN def: "Hepatocyte growth factor receptor precursor" [UniProtKB:P08581] synonym: "c-Met" EXACT [UniProtKB:P08581] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P08581] synonym: "HGF receptor" EXACT [UniProtKB:P08581] synonym: "HGF/SF receptor" EXACT [UniProtKB:P08581] synonym: "Met proto-oncogene tyrosine kinase" EXACT [UniProtKB:P08581] synonym: "Scatter factor receptor" EXACT [UniProtKB:P08581] synonym: "SF receptor" EXACT [UniProtKB:P08581] xref: EMBL:AAA59590.1 xref: EMBL:AAA59591.1 xref: EMBL:AAB54047.1 xref: EMBL:AAB60323.1 xref: EMBL:AAC60383.1 xref: EMBL:AAF66137.2 xref: EMBL:CAB56793.1 xref: UniProtKB:O60366 xref: UniProtKB:P08581 xref: UniProtKB:Q12875 xref: UniProtKB:Q9UDX7 xref: UniProtKB:Q9UPL8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005086 ! MET_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006236 ! hgf-met-1 direct interaction relationship: transforms_into CCO:B0012911 ! MET_HUMAN-Phosphothreonine977 relationship: transforms_into CCO:B0012912 ! MET_HUMAN-Phosphoserine988 relationship: transforms_into CCO:B0012913 ! MET_HUMAN-Phosphoserine990 relationship: transforms_into CCO:B0012914 ! MET_HUMAN-Phosphotyrosine1003 relationship: transforms_into CCO:B0012915 ! MET_HUMAN-Phosphotyrosine1235 relationship: transforms_into CCO:B0012916 ! MET_HUMAN-Phosphotyrosine1356 [Term] id: CCO:B0005440 name: FBX25_HUMAN def: "F-box only protein 25" [UniProtKB:Q8TCJ0] xref: EMBL:AAF04526.1 xref: EMBL:AAH20249.1 xref: EMBL:AAH50393.1 xref: EMBL:AAP97293.1 xref: EMBL:BAB85128.1 xref: UniProtKB:Q6PJ83 xref: UniProtKB:Q7Z4V4 xref: UniProtKB:Q8TCJ0 xref: UniProtKB:Q9UKB8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004623 ! FBXO25_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006242 ! fbxo25-cul1-1 physical interaction [Term] id: CCO:B0005441 name: FBX4_HUMAN def: "F-box only protein 4" [UniProtKB:Q9UKT5] xref: EMBL:AAF03703.1 xref: EMBL:AAF04468.1 xref: EMBL:AAH48098.1 xref: EMBL:CAH18486.1 xref: UniProtKB:Q68CU8 xref: UniProtKB:Q86VT8 xref: UniProtKB:Q9UK98 xref: UniProtKB:Q9UKT5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004625 ! FBXO4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006243 ! fbxo4-cul1-2 physical interaction relationship: transforms_into CCO:B0011870 ! FBX4_HUMAN-Phosphoserine12 relationship: transforms_into CCO:B0011871 ! FBX4_HUMAN-Phosphoserine238 relationship: transforms_into CCO:B0011872 ! FBX4_HUMAN-Phosphothreonine239 relationship: transforms_into CCO:B0011873 ! FBX4_HUMAN-Phosphothreonine240 [Term] id: CCO:B0005442 name: FBX7_HUMAN def: "F-box only protein 7" [UniProtKB:Q9Y3I1] xref: EMBL:AAF04471.1 xref: EMBL:AAF67155.1 xref: EMBL:AAH08361.1 xref: EMBL:CAB43356.1 xref: EMBL:CAG30377.1 xref: EMBL:CAI18782.1 xref: EMBL:CAI19333.1 xref: EMBL:CAI19587.1 xref: UniProtKB:Q5TGC4 xref: UniProtKB:Q96HM6 xref: UniProtKB:Q9UF21 xref: UniProtKB:Q9UKT2 xref: UniProtKB:Q9Y3I1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004627 ! FBXO7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006244 ! fbxo7-cul1-1 physical interaction [Term] id: CCO:B0005443 name: PARK7_HUMAN def: "Protein DJ-1" [UniProtKB:Q99497] synonym: "Oncogene DJ1" EXACT [UniProtKB:Q99497] synonym: "Parkinson disease protein 7" EXACT [UniProtKB:Q99497] xref: EMBL:AAC12806.1 xref: EMBL:AAH08188.1 xref: EMBL:AAT68961.1 xref: EMBL:BAA09603.2 xref: EMBL:BAB71782.1 xref: EMBL:CAB52550.1 xref: UniProtKB:O14805 xref: UniProtKB:Q6DR95 xref: UniProtKB:Q7LFU2 xref: UniProtKB:Q99497 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005267 ! PARK7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007173 ! dj_1-ubc9 physical interaction relationship: transforms_into CCO:B0013396 ! PARK7_HUMAN-Phosphotyrosine67 relationship: transforms_into CCO:B0013397 ! PARK7_HUMAN-Cysteine sulfinic acid (-SO2H)106 [Term] id: CCO:B0005444 name: CHD8_HUMAN def: "Chromodomain-helicase-DNA-binding protein 8" [UniProtKB:Q9HCK8] synonym: "ATP-dependent helicase CHD8" EXACT [UniProtKB:Q9HCK8] synonym: "CHD-8" EXACT [UniProtKB:Q9HCK8] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9HCK8] synonym: "Helicase with SNF2 domain 1" EXACT [UniProtKB:Q9HCK8] xref: EMBL:AAH11695.2 xref: EMBL:AAH25964.1 xref: EMBL:AAH36920.1 xref: EMBL:BAB13390.3 xref: EMBL:CAD39180.1 xref: EMBL:CAH18170.1 xref: UniProtKB:Q68DQ0 xref: UniProtKB:Q8N3Z9 xref: UniProtKB:Q8NCY4 xref: UniProtKB:Q8TBR9 xref: UniProtKB:Q96F26 xref: UniProtKB:Q9HCK8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004345 ! CHD8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006247 ! ctcf-chd8-5 colocalization relationship: participates_in CCO:I0006781 ! ctcf-chd8-3 physical interaction relationship: participates_in CCO:I0006782 ! ctcf-chd8-4 colocalization relationship: transforms_into CCO:B0011204 ! CHD8_HUMAN-Phosphothreonine258 relationship: transforms_into CCO:B0011205 ! CHD8_HUMAN-Phosphothreonine1119 relationship: transforms_into CCO:B0011206 ! CHD8_HUMAN-Phosphoserine1141 relationship: transforms_into CCO:B0011207 ! CHD8_HUMAN-Phosphoserine1145 relationship: transforms_into CCO:B0011208 ! CHD8_HUMAN-Phosphoserine1790 relationship: transforms_into CCO:B0011209 ! CHD8_HUMAN-Phosphoserine1792 [Term] id: CCO:B0005445 name: SDC2_HUMAN def: "Syndecan-2 precursor" [UniProtKB:P34741] synonym: "Fibroglycan" EXACT [UniProtKB:P34741] synonym: "Heparan sulfate proteoglycan core protein" EXACT [UniProtKB:P34741] synonym: "HSPG" EXACT [UniProtKB:P34741] synonym: "SYND2" EXACT [UniProtKB:P34741] xref: EMBL:AAA52701.1 xref: EMBL:AAH49836.1 xref: EMBL:BAB15150.1 xref: UniProtKB:P34741 xref: UniProtKB:Q9H6V1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005576 ! SDC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006248 ! nf1-sdc2 physical interaction relationship: participates_in CCO:I0006249 ! nf1-sdc2-1 physical interaction relationship: participates_in CCO:I0006250 ! nf1-sdc2-3 physical interaction relationship: participates_in CCO:I0006251 ! nf1-sdc2-4 physical interaction [Term] id: CCO:B0005446 name: AATF_HUMAN def: "Protein AATF" [UniProtKB:Q9NY61] synonym: "Apoptosis-antagonizing transcription factor" EXACT [UniProtKB:Q9NY61] synonym: "Rb-binding protein Che-1" EXACT [UniProtKB:Q9NY61] xref: EMBL:AAD52016.1 xref: EMBL:AAF28955.1 xref: EMBL:AAH00591.1 xref: EMBL:CAB57451.2 xref: EMBL:EAW57575.1 xref: UniProtKB:A6NCJ6 xref: UniProtKB:Q9NY61 xref: UniProtKB:Q9P0A4 xref: UniProtKB:Q9UNX5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004009 ! AATF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006252 ! atm-aatf-1 phosphorylation relationship: participates_in CCO:I0006253 ! atr-aatf-2 phosphorylation relationship: participates_in CCO:I0006254 ! chek2-aatf-2 phosphorylation relationship: participates_in CCO:I0006255 ! chek1-aatf phosphorylation relationship: participates_in CCO:I0006256 ! atm-aatf-2 phosphorylation relationship: participates_in CCO:I0006257 ! chek2-aatf-3 phosphorylation relationship: participates_in CCO:I0006492 ! mphosph6-ded physical interaction relationship: participates_in CCO:I0007041 ! chek2-aatf physical interaction relationship: participates_in CCO:I0007178 ! chek2-aatf-1 physical interaction relationship: participates_in CCO:I0007945 ! atm-aatf physical interaction relationship: transforms_into CCO:B0010391 ! AATF_HUMAN-Phosphoserine203 relationship: transforms_into CCO:B0010392 ! AATF_HUMAN-Phosphoserine316 relationship: transforms_into CCO:B0010393 ! AATF_HUMAN-Phosphoserine320 relationship: transforms_into CCO:B0010394 ! AATF_HUMAN-Phosphoserine321 [Term] id: CCO:B0005448 name: CLCA_HUMAN def: "Clathrin light chain A" [UniProtKB:P09496] synonym: "Lca" EXACT [UniProtKB:P09496] xref: EMBL:AAA51817.1 xref: EMBL:AAA59505.1 xref: EMBL:AAH09201.1 xref: EMBL:AAH19287.1 xref: EMBL:AAP35834.1 xref: EMBL:ABB76683.1 xref: EMBL:CAD13387.1 xref: EMBL:CAD13388.1 xref: UniProtKB:P09496 xref: UniProtKB:Q2XPN5 xref: UniProtKB:Q53XZ1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004368 ! CLTA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0007516 ! egfr-cav1-clca physical interaction [Term] id: CCO:B0005449 name: TBA4A_HUMAN def: "Tubulin alpha-4A chain" [UniProtKB:P68366] synonym: "Alpha-tubulin 1" EXACT [UniProtKB:P68366] synonym: "Testis-specific alpha-tubulin" EXACT [UniProtKB:P68366] synonym: "Tubulin alpha-1 chain" EXACT [UniProtKB:P68366] synonym: "Tubulin H2-alpha" EXACT [UniProtKB:P68366] xref: EMBL:AAH09238.1 xref: EMBL:AAP35377.1 xref: EMBL:AAW65371.1 xref: EMBL:CAA30026.1 xref: UniProtKB:P05215 xref: UniProtKB:P68366 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005732 ! TUBA4A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: transforms_into CCO:B0014312 ! TBA4A_HUMAN-Phosphoserine6 relationship: transforms_into CCO:B0014313 ! TBA4A_HUMAN-Phosphotyrosine161 relationship: transforms_into CCO:B0014314 ! TBA4A_HUMAN-Phosphotyrosine272 relationship: transforms_into CCO:B0031377 ! TBA4A_HUMAN-Phosphotyrosine319 relationship: transforms_into CCO:B0041205 ! TBA4A_HUMAN-Phosphoserine439 relationship: transforms_into CCO:B0041206 ! TBA4A_HUMAN-Phosphotyrosine440 [Term] id: CCO:B0005450 name: ICAM1_HUMAN def: "Intercellular adhesion molecule 1 precursor" [UniProtKB:P05362] synonym: "CD54 antigen" EXACT [UniProtKB:P05362] synonym: "ICAM-1" EXACT [UniProtKB:P05362] synonym: "Major group rhinovirus receptor" EXACT [UniProtKB:P05362] xref: EMBL:AAA52708.1 xref: EMBL:AAA52709.1 xref: EMBL:AAH15969.1 xref: EMBL:AAO30128.1 xref: EMBL:AAP35500.1 xref: EMBL:CAA30051.1 xref: EMBL:CAA40441.1 xref: EMBL:CAA41977.1 xref: UniProtKB:P05362 xref: UniProtKB:Q96B50 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004847 ! ICAM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction [Term] id: CCO:B0005451 name: HXC10_HUMAN def: "Homeobox protein Hox-C10" [UniProtKB:Q9NYD6] xref: EMBL:AAF67759.1 xref: EMBL:AAH01293.1 xref: EMBL:CAA67999.1 xref: EMBL:CAA68000.1 xref: UniProtKB:O15219 xref: UniProtKB:O15220 xref: UniProtKB:Q9BVD5 xref: UniProtKB:Q9NYD6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004845 ! HOXC10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction [Term] id: CCO:B0005452 name: SEC13_HUMAN def: "Protein SEC13 homolog" [UniProtKB:P55735] synonym: "SEC13-like protein 1" EXACT [UniProtKB:P55735] synonym: "SEC13-related protein" EXACT [UniProtKB:P55735] xref: EMBL:AAH02634.2 xref: EMBL:AAH06167.1 xref: EMBL:AAH91506.1 xref: UniProtKB:P55735 xref: UniProtKB:Q5BJF0 xref: UniProtKB:Q9BRM6 xref: UniProtKB:Q9BUG7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005578 ! SEC13_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction [Term] id: CCO:B0005453 name: AT1B1_HUMAN def: "Sodium/potassium-transporting ATPase subunit beta-1" [UniProtKB:P05026] synonym: "Sodium/potassium-dependent ATPase subunit beta-1" EXACT [UniProtKB:P05026] xref: EMBL:AAA36352.1 xref: EMBL:AAC50132.1 xref: EMBL:AAH00006.1 xref: EMBL:AAP88789.1 xref: EMBL:CAA27385.1 xref: EMBL:CAA35040.1 xref: EMBL:CAI18888.1 xref: UniProtKB:P05026 xref: UniProtKB:Q5TGZ3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004112 ! ATP1B1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0008193 ! atp1b1-rif1 physical interaction relationship: transforms_into CCO:B0031296 ! AT1B1_HUMAN-Phosphotyrosine101 [Term] id: CCO:B0005454 name: GRB2_HUMAN def: "Growth factor receptor-bound protein 2" [UniProtKB:P62993] synonym: "Adapter protein GRB2" EXACT [UniProtKB:P62993] synonym: "Protein Ash" EXACT [UniProtKB:P62993] synonym: "SH2/SH3 adapter GRB2" EXACT [UniProtKB:P62993] xref: EMBL:AAA58448.1 xref: EMBL:AAC37549.1 xref: EMBL:AAC72075.1 xref: EMBL:AAH00631.1 xref: EMBL:AAM21073.1 xref: EMBL:CAA44664.1 xref: EMBL:CAG46740.1 xref: UniProtKB:P29354 xref: UniProtKB:P62993 xref: UniProtKB:Q14450 xref: UniProtKB:Q63057 xref: UniProtKB:Q63059 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004725 ! GRB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0006278 ! egfr-grb2 physical interaction relationship: participates_in CCO:I0006618 ! khdrbs1-grb2-1 physical interaction relationship: participates_in CCO:I0006621 ! khdrbs1-grb2-2 physical interaction relationship: participates_in CCO:I0006677 ! grb2-egfr-1 physical interaction relationship: participates_in CCO:I0006842 ! egfr-grb2-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007516 ! egfr-cav1-clca physical interaction relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: participates_in CCO:I0007966 ! grb2-sam68-1 physical interaction relationship: participates_in CCO:I0007967 ! grb2-sam68-2 physical interaction relationship: transforms_into CCO:B0011973 ! GRB2_HUMAN-Phosphotyrosine160 relationship: transforms_into CCO:B0011974 ! GRB2_HUMAN-Phosphotyrosine209 [Term] id: CCO:B0005455 name: CD166_HUMAN def: "CD166 antigen precursor" [UniProtKB:Q13740] synonym: "Activated leukocyte cell adhesion molecule" EXACT [UniProtKB:Q13740] xref: EMBL:AAB59499.1 xref: EMBL:ABF48405.1 xref: EMBL:ABF48406.1 xref: EMBL:CAA71256.1 xref: UniProtKB:O60892 xref: UniProtKB:Q13740 xref: UniProtKB:Q1HGM8 xref: UniProtKB:Q1HGM9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004269 ! ALCAM_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction [Term] id: CCO:B0005456 name: CAV1_HUMAN def: "Caveolin-1" [UniProtKB:Q03135] xref: EMBL:AAD23745.1 xref: EMBL:AAD34722.1 xref: EMBL:AAH09685.1 xref: EMBL:AAH82246.1 xref: EMBL:AAP35807.1 xref: EMBL:CAA79476.1 xref: EMBL:CAB63654.1 xref: UniProtKB:Q03135 xref: UniProtKB:Q9UGP1 xref: UniProtKB:Q9UNG1 xref: UniProtKB:Q9UQH6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004224 ! CAV1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007516 ! egfr-cav1-clca physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0010929 ! CAV1_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0010930 ! CAV1_HUMAN-Phosphotyrosine6 relationship: transforms_into CCO:B0010931 ! CAV1_HUMAN-Phosphotyrosine14 relationship: transforms_into CCO:B0010932 ! CAV1_HUMAN-Phosphotyrosine25 relationship: transforms_into CCO:B0010933 ! CAV1_HUMAN-Phosphoserine37 [Term] id: CCO:B0005457 name: LYN_HUMAN def: "Tyrosine-protein kinase Lyn" [UniProtKB:P07948] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P07948] xref: EMBL:AAA59540.1 xref: EMBL:AAB50019.1 xref: EMBL:AAH75001.1 xref: EMBL:AAH75002.1 xref: EMBL:AAI26457.1 xref: EMBL:AAI26459.1 xref: UniProtKB:A0AVQ5 xref: UniProtKB:P07948 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004998 ! LYN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0006712 ! khdrbs1-lyn-1 physical interaction relationship: participates_in CCO:I0006944 ! cdkn1b-lyn-2 phosphorylation relationship: participates_in CCO:I0007486 ! cdkn1b-lyn-1 physical interaction relationship: participates_in CCO:I0007516 ! egfr-cav1-clca physical interaction relationship: transforms_into CCO:B0012709 ! LYN_HUMAN-Phosphoserine11 relationship: transforms_into CCO:B0012710 ! LYN_HUMAN-Phosphoserine13 relationship: transforms_into CCO:B0012711 ! LYN_HUMAN-Phosphotyrosine397 relationship: transforms_into CCO:B0012712 ! LYN_HUMAN-Phosphotyrosine508 relationship: transforms_into CCO:B0031336 ! LYN_HUMAN-Phosphotyrosine193 relationship: transforms_into CCO:B0031337 ! LYN_HUMAN-Phosphotyrosine194 [Term] id: CCO:B0005458 name: G3P_HUMAN def: "Glyceraldehyde-3-phosphate dehydrogenase" [UniProtKB:P04406] synonym: "EC 1.2.1.12" EXACT [UniProtKB:P04406] synonym: "GAPDH" EXACT [UniProtKB:P04406] xref: EMBL:AAA52496.1 xref: EMBL:AAA52518.1 xref: EMBL:AAA53191.1 xref: EMBL:AAA86283.1 xref: EMBL:AAF99678.1 xref: EMBL:AAG01996.1 xref: EMBL:AAH01601.1 xref: EMBL:AAH04109.1 xref: EMBL:AAH09081.1 xref: EMBL:AAH13310.1 xref: EMBL:AAH23632.1 xref: EMBL:AAH25925.1 xref: EMBL:AAH26907.1 xref: EMBL:AAH29618.1 xref: EMBL:AAH83511.1 xref: EMBL:AAP35539.1 xref: EMBL:AAP88932.1 xref: EMBL:BAB93466.1 xref: EMBL:CAA25833.1 xref: EMBL:CAA37794.1 xref: UniProtKB:P00354 xref: UniProtKB:P04406 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004669 ! GAPDH_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007516 ! egfr-cav1-clca physical interaction relationship: transforms_into CCO:B0011913 ! G3P_HUMAN-Phosphotyrosine42 relationship: transforms_into CCO:B0011914 ! G3P_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0011915 ! G3P_HUMAN-Phosphothreonine211 relationship: transforms_into CCO:B0031322 ! G3P_HUMAN-Phosphotyrosine314 relationship: transforms_into CCO:B0031323 ! G3P_HUMAN-Phosphotyrosine320 [Term] id: CCO:B0005459 name: AT1A1_HUMAN def: "Sodium/potassium-transporting ATPase subunit alpha-1 precursor" [UniProtKB:P05023] synonym: "EC 3.6.3.9" EXACT [UniProtKB:P05023] synonym: "Na(+)/K(+) ATPase alpha-1 subunit" EXACT [UniProtKB:P05023] synonym: "Sodium pump subunit alpha-1" EXACT [UniProtKB:P05023] xref: EMBL:AAA35573.1 xref: EMBL:AAA35574.2 xref: EMBL:AAA51801.1 xref: EMBL:AAA51803.1 xref: EMBL:AAA92713.1 xref: EMBL:AAC50131.1 xref: EMBL:AAD56251.1 xref: EMBL:AAD56252.1 xref: EMBL:AAH01330.1 xref: EMBL:AAH03077.1 xref: EMBL:AAH50359.1 xref: EMBL:BAA00061.1 xref: EMBL:CAA27390.1 xref: EMBL:CAA27840.1 xref: EMBL:CAI22199.1 xref: UniProtKB:P05023 xref: UniProtKB:Q16689 xref: UniProtKB:Q6LDM4 xref: UniProtKB:Q9UJ20 xref: UniProtKB:Q9UJ21 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004111 ! ATP1A1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: transforms_into CCO:B0010633 ! AT1A1_HUMAN-Phosphotyrosine10 relationship: transforms_into CCO:B0010634 ! AT1A1_HUMAN-Phosphoserine16 relationship: transforms_into CCO:B0010635 ! AT1A1_HUMAN-Phosphoserine47 relationship: transforms_into CCO:B0010636 ! AT1A1_HUMAN-Phosphoserine217 relationship: transforms_into CCO:B0010637 ! AT1A1_HUMAN-Phosphothreonine219 relationship: transforms_into CCO:B0010638 ! AT1A1_HUMAN-Phosphoserine228 relationship: transforms_into CCO:B0010639 ! AT1A1_HUMAN-Phosphoserine452 relationship: transforms_into CCO:B0010640 ! AT1A1_HUMAN-Phosphoserine943 relationship: transforms_into CCO:B0031295 ! AT1A1_HUMAN-Phosphotyrosine260 [Term] id: CCO:B0005460 name: CLH2_HUMAN def: "Clathrin heavy chain 2" [UniProtKB:P53675] synonym: "CLH-22" EXACT [UniProtKB:P53675] xref: EMBL:AAB40908.1 xref: EMBL:AAB40909.1 xref: EMBL:AAC50494.1 xref: EMBL:CAA64752.1 xref: EMBL:CAA64753.1 xref: UniProtKB:P53675 xref: UniProtKB:Q14017 xref: UniProtKB:Q15808 xref: UniProtKB:Q15809 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004369 ! CLTCL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: transforms_into CCO:B0011260 ! CLH2_HUMAN-Phosphothreonine103 [Term] id: CCO:B0005461 name: S10A9_HUMAN def: "Protein S100-A9" [UniProtKB:P06702] synonym: "Calgranulin-B" EXACT [UniProtKB:P06702] synonym: "Calprotectin L1H subunit" EXACT [UniProtKB:P06702] synonym: "Leukocyte L1 complex heavy chain" EXACT [UniProtKB:P06702] synonym: "Migration inhibitory factor-related protein 14" EXACT [UniProtKB:P06702] synonym: "MRP-14" EXACT [UniProtKB:P06702] synonym: "P14" EXACT [UniProtKB:P06702] synonym: "S100 calcium-binding protein A9" EXACT [UniProtKB:P06702] xref: EMBL:AAA36326.1 xref: EMBL:AAA68480.1 xref: EMBL:AAF62536.1 xref: EMBL:AAF62537.1 xref: EMBL:AAH47681.1 xref: EMBL:CAA29579.1 xref: EMBL:CAG47003.1 xref: EMBL:CAG47020.1 xref: EMBL:CAI19494.1 xref: UniProtKB:P06702 xref: UniProtKB:Q6FGA1 xref: UniProtKB:Q9NYM0 xref: UniProtKB:Q9UCJ1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005554 ! S100A9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0007516 ! egfr-cav1-clca physical interaction relationship: transforms_into CCO:B0013949 ! S10A9_HUMAN-Phosphothreonine113 relationship: transforms_into CCO:B0041180 ! S10A9_HUMAN-Blocked amino end (Thr)2 [Term] id: CCO:B0005462 name: CAV2_HUMAN def: "Caveolin-2" [UniProtKB:P51636] xref: EMBL:AAB88492.1 xref: EMBL:AAH05256.1 xref: EMBL:AAP35700.1 xref: EMBL:CAB63653.1 xref: EMBL:CAB65090.1 xref: UniProtKB:P51636 xref: UniProtKB:Q9UGM7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004225 ! CAV2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: transforms_into CCO:B0010934 ! CAV2_HUMAN-Phosphotyrosine19 relationship: transforms_into CCO:B0010935 ! CAV2_HUMAN-Phosphoserine20 relationship: transforms_into CCO:B0010936 ! CAV2_HUMAN-Phosphoserine23 relationship: transforms_into CCO:B0010937 ! CAV2_HUMAN-Phosphotyrosine27 relationship: transforms_into CCO:B0010938 ! CAV2_HUMAN-Phosphoserine36 [Term] id: CCO:B0005463 name: 4F2_HUMAN def: "4F2 cell-surface antigen heavy chain" [UniProtKB:P08195] synonym: "4F2 heavy chain antigen" EXACT [UniProtKB:P08195] synonym: "4F2hc" EXACT [UniProtKB:P08195] synonym: "CD98 antigen" EXACT [UniProtKB:P08195] synonym: "Lymphocyte activation antigen 4F2 large subunit" EXACT [UniProtKB:P08195] xref: EMBL:AAA35489.1 xref: EMBL:AAA35536.1 xref: EMBL:AAA51540.1 xref: EMBL:AAA52497.1 xref: EMBL:AAH01061.2 xref: EMBL:AAH03000.2 xref: EMBL:BAA84649.1 xref: UniProtKB:P08195 xref: UniProtKB:Q13543 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004005 ! SLC3A2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006261 ! egfr-calm-cav1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007516 ! egfr-cav1-clca physical interaction relationship: transforms_into CCO:B0010380 ! 4F2_HUMAN-Phosphoserine2 relationship: transforms_into CCO:B0010381 ! 4F2_HUMAN-Phosphothreonine5 [Term] id: CCO:B0005464 name: SRC_HUMAN def: "Proto-oncogene tyrosine-protein kinase Src" [UniProtKB:P12931] synonym: "c-Src" EXACT [UniProtKB:P12931] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P12931] synonym: "p60-Src" EXACT [UniProtKB:P12931] synonym: "pp60c-src" EXACT [UniProtKB:P12931] xref: EMBL:AAA60584.1 xref: EMBL:AAH11566.1 xref: EMBL:AAH51270.2 xref: EMBL:CAA26485.1 xref: EMBL:CAC34523.1 xref: UniProtKB:P12931 xref: UniProtKB:Q86VB9 xref: UniProtKB:Q9H5A8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005670 ! SRC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006262 ! src-cdn1b-1 phosphorylation relationship: participates_in CCO:I0008166 ! src-khdrbs1 physical interaction relationship: transforms_into CCO:B0014208 ! SRC_HUMAN-Phosphoserine17 relationship: transforms_into CCO:B0014209 ! SRC_HUMAN-Phosphoserine69 relationship: transforms_into CCO:B0014210 ! SRC_HUMAN-Phosphoserine75 relationship: transforms_into CCO:B0014211 ! SRC_HUMAN-Phosphotyrosine419 relationship: transforms_into CCO:B0014212 ! SRC_HUMAN-Phosphotyrosine530 relationship: transforms_into CCO:B0031376 ! SRC_HUMAN-Phosphotyrosine187 relationship: transforms_into CCO:B0041198 ! SRC_HUMAN-Phosphothreonine74 [Term] id: CCO:B0005465 name: YES_HUMAN def: "Proto-oncogene tyrosine-protein kinase Yes" [UniProtKB:P07947] synonym: "c-Yes" EXACT [UniProtKB:P07947] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P07947] synonym: "p61-Yes" EXACT [UniProtKB:P07947] xref: EMBL:AAA35735.1 xref: EMBL:AAH48960.1 xref: EMBL:EAX01709.1 xref: UniProtKB:A6NLB3 xref: UniProtKB:P07947 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005949 ! YES1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006263 ! yes-cdn1b-1 phosphorylation relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0014729 ! YES_HUMAN-Phosphotyrosine426 relationship: transforms_into CCO:B0014730 ! YES_HUMAN-Phosphotyrosine537 relationship: transforms_into CCO:B0031386 ! YES_HUMAN-Phosphotyrosine194 relationship: transforms_into CCO:B0031387 ! YES_HUMAN-Phosphotyrosine222 [Term] id: CCO:B0005469 name: PAK1_HUMAN def: "Serine/threonine-protein kinase PAK 1" [UniProtKB:Q13153] synonym: "Alpha-PAK" EXACT [UniProtKB:Q13153] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q13153] synonym: "p21-activated kinase 1" EXACT [UniProtKB:Q13153] synonym: "p65-PAK" EXACT [UniProtKB:Q13153] synonym: "PAK-1" EXACT [UniProtKB:Q13153] xref: EMBL:AAA65441.1 xref: EMBL:AAC24716.1 xref: EMBL:AAC50590.1 xref: EMBL:AAI09300.1 xref: UniProtKB:O75561 xref: UniProtKB:Q13153 xref: UniProtKB:Q13567 xref: UniProtKB:Q32M53 xref: UniProtKB:Q32M54 xref: UniProtKB:Q86W79 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005256 ! PAK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006266 ! cdc2l1-pak1-1 physical interaction relationship: participates_in CCO:I0006667 ! cdc2l1-pak1-ac-vit physical interaction relationship: participates_in CCO:I0007946 ! cdc2l1-pak1-2 physical interaction relationship: transforms_into CCO:B0013375 ! PAK1_HUMAN-Phosphoserine21 relationship: transforms_into CCO:B0013376 ! PAK1_HUMAN-Phosphoserine57 relationship: transforms_into CCO:B0013377 ! PAK1_HUMAN-Phosphothreonine84 relationship: transforms_into CCO:B0013378 ! PAK1_HUMAN-Phosphoserine144 relationship: transforms_into CCO:B0013379 ! PAK1_HUMAN-Phosphoserine149 relationship: transforms_into CCO:B0013380 ! PAK1_HUMAN-Phosphoserine199 relationship: transforms_into CCO:B0013381 ! PAK1_HUMAN-Phosphoserine204 relationship: transforms_into CCO:B0013382 ! PAK1_HUMAN-Phosphothreonine212 relationship: transforms_into CCO:B0013383 ! PAK1_HUMAN-Phosphoserine220 relationship: transforms_into CCO:B0013384 ! PAK1_HUMAN-Phosphoserine223 relationship: transforms_into CCO:B0013385 ! PAK1_HUMAN-Phosphothreonine225 relationship: transforms_into CCO:B0013386 ! PAK1_HUMAN-Phosphothreonine423 [Term] id: CCO:B0005471 name: BRAP_HUMAN def: "BRCA1-associated protein" [UniProtKB:Q7Z569] synonym: "BRAP2" EXACT [UniProtKB:Q7Z569] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q7Z569] synonym: "IMP" EXACT [UniProtKB:Q7Z569] synonym: "Impedes mitogenic signal propagation" EXACT [UniProtKB:Q7Z569] synonym: "Renal carcinoma antigen NY-REN-63" EXACT [UniProtKB:Q7Z569] synonym: "RING finger protein 52" EXACT [UniProtKB:Q7Z569] xref: EMBL:AAB88538.1 xref: EMBL:AAC24200.1 xref: EMBL:AAP93638.1 xref: UniProtKB:O43238 xref: UniProtKB:O75341 xref: UniProtKB:Q7Z569 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004185 ! BRAP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007523 ! brap-brca1 physical interaction relationship: participates_in CCO:I0007524 ! brca1-brap physical interaction relationship: participates_in CCO:I0007839 ! brca1-brap-2 physical interaction relationship: participates_in CCO:I0008527 ! ddb1-brap physical interaction relationship: transforms_into CCO:B0010838 ! BRAP_HUMAN-Phosphoserine117 [Term] id: CCO:B0005472 name: SUMO1_HUMAN def: "Small ubiquitin-related modifier 1 precursor" [UniProtKB:P63165] synonym: "GAP-modifying protein 1" EXACT [UniProtKB:P63165] synonym: "GMP1" EXACT [UniProtKB:P63165] synonym: "Sentrin" EXACT [UniProtKB:P63165] synonym: "SMT3 homolog 3" EXACT [UniProtKB:P63165] synonym: "SUMO-1" EXACT [UniProtKB:P63165] synonym: "Ubiquitin-homology domain protein PIC1" EXACT [UniProtKB:P63165] synonym: "Ubiquitin-like protein SMT3C" EXACT [UniProtKB:P63165] synonym: "Ubiquitin-like protein UBL1" EXACT [UniProtKB:P63165] xref: EMBL:AAB39999.1 xref: EMBL:AAB40388.1 xref: EMBL:AAB40390.1 xref: EMBL:AAC50733.1 xref: EMBL:AAC50996.1 xref: EMBL:AAH06462.1 xref: EMBL:AAH53528.1 xref: EMBL:AAH66306.1 xref: EMBL:AAP35278.1 xref: EMBL:AAY24035.1 xref: EMBL:BAB93477.1 xref: EMBL:CAA67898.1 xref: EMBL:CAG46944.1 xref: EMBL:CAG46953.1 xref: UniProtKB:P55856 xref: UniProtKB:P63165 xref: UniProtKB:Q6FGG0 xref: UniProtKB:Q6NZ62 xref: UniProtKB:Q93068 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005704 ! SUMO1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006271 ! pml-ubl_1-1 physical interaction relationship: transforms_into CCO:B0014272 ! SUMO1_HUMAN-Phosphoserine2 [Term] id: CCO:B0005474 name: A4_HUMAN def: "Amyloid beta A4 protein precursor" [UniProtKB:P05067] synonym: "ABPP" EXACT [UniProtKB:P05067] synonym: "Alzheimer disease amyloid protein" EXACT [UniProtKB:P05067] synonym: "APP" EXACT [UniProtKB:P05067] synonym: "APPI" EXACT [UniProtKB:P05067] synonym: "Cerebral vascular amyloid peptide" EXACT [UniProtKB:P05067] synonym: "CVAP" EXACT [UniProtKB:P05067] synonym: "PN-II" EXACT [UniProtKB:P05067] synonym: "PreA4" EXACT [UniProtKB:P05067] synonym: "Protease nexin-II" EXACT [UniProtKB:P05067] xref: EMBL:AAA35540.1 xref: EMBL:AAA51564.1 xref: EMBL:AAA51722.1 xref: EMBL:AAA51726.1 xref: EMBL:AAA51727.1 xref: EMBL:AAA51768.1 xref: EMBL:AAA58727.1 xref: EMBL:AAA60163.1 xref: EMBL:AAB23646.1 xref: EMBL:AAB26263.2 xref: EMBL:AAB26264.2 xref: EMBL:AAB26265.2 xref: EMBL:AAB59501.1 xref: EMBL:AAB59502.1 xref: EMBL:AAC13654.1 xref: EMBL:AAC60601.2 xref: EMBL:AAH04369.1 xref: EMBL:AAQ14327.1 xref: EMBL:AAW82435.1 xref: EMBL:BAA22264.1 xref: EMBL:CAA30041.1 xref: EMBL:CAA30042.1 xref: EMBL:CAA30050.1 xref: EMBL:CAA31830.1 xref: EMBL:CAA68374.1 xref: UniProtKB:P05067 xref: UniProtKB:P09000 xref: UniProtKB:P78438 xref: UniProtKB:Q13764 xref: UniProtKB:Q13778 xref: UniProtKB:Q13793 xref: UniProtKB:Q16011 xref: UniProtKB:Q16014 xref: UniProtKB:Q16019 xref: UniProtKB:Q16020 xref: UniProtKB:Q9BT38 xref: UniProtKB:Q9UCA9 xref: UniProtKB:Q9UCB6 xref: UniProtKB:Q9UCC8 xref: UniProtKB:Q9UCD1 xref: UniProtKB:Q9UQ58 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004007 ! APP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006279 ! app-apbb1-2 physical interaction relationship: participates_in CCO:I0006333 ! tgfb1-bapp-1 physical interaction relationship: participates_in CCO:I0006334 ! tgfb2-bapp-5 physical interaction relationship: participates_in CCO:I0006335 ! sch1-app-3 physical interaction relationship: participates_in CCO:I0006541 ! shc1-app-2 physical interaction relationship: participates_in CCO:I0006542 ! shc1-app-1 physical interaction relationship: participates_in CCO:I0006629 ! sch1-app-2 physical interaction relationship: participates_in CCO:I0006668 ! app-tp53bp2-2 physical interaction relationship: participates_in CCO:I0006669 ! apbb2-app-2 physical interaction relationship: participates_in CCO:I0006986 ! tgfb2-bapp-2 physical interaction relationship: participates_in CCO:I0006987 ! tgfb2-bapp-3 physical interaction relationship: participates_in CCO:I0006992 ! apbb2 -app-1 physical interaction relationship: participates_in CCO:I0007061 ! apbb1-app physical interaction relationship: participates_in CCO:I0007284 ! app-tp53bp2-1 physical interaction relationship: participates_in CCO:I0007285 ! app-tp53bp2-3 physical interaction relationship: participates_in CCO:I0007390 ! sch1-app-4 physical interaction relationship: participates_in CCO:I0007411 ! app-apbb1-6 physical interaction relationship: participates_in CCO:I0007448 ! tgfb2-bapp-1 physical interaction relationship: participates_in CCO:I0007585 ! tgfb2-bapp-4 physical interaction relationship: participates_in CCO:I0007604 ! app-nsf-1 physical interaction relationship: participates_in CCO:I0007727 ! app-apbb1-5 physical interaction relationship: participates_in CCO:I0007784 ! tgfb1-tgfb2-bapp-2 physical interaction relationship: transforms_into CCO:B0010382 ! A4_HUMAN-Phosphoserine198 relationship: transforms_into CCO:B0010383 ! A4_HUMAN-Phosphoserine206 relationship: transforms_into CCO:B0010384 ! A4_HUMAN-Phosphothreonine729 relationship: transforms_into CCO:B0010385 ! A4_HUMAN-Phosphoserine730 relationship: transforms_into CCO:B0010386 ! A4_HUMAN-Phosphothreonine743 relationship: transforms_into CCO:B0010387 ! A4_HUMAN-Phosphotyrosine757 [Term] id: CCO:B0005475 name: MED9_HUMAN def: "Mediator of RNA polymerase II transcription subunit 9" [UniProtKB:Q9NWA0] synonym: "Mediator complex subunit 9" EXACT [UniProtKB:Q9NWA0] xref: EMBL:AAI04989.1 xref: EMBL:AAI12030.1 xref: EMBL:BAA91483.1 xref: EMBL:EAW55706.1 xref: UniProtKB:Q9NWA0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005079 ! MED9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006506 ! q9nwa0-q71f56-1 physical interaction [Term] id: CCO:B0005477 name: TRIB3_HUMAN def: "Tribbles homolog 3" [UniProtKB:Q96RU7] synonym: "Neuronal cell death-inducible putative kinase" EXACT [UniProtKB:Q96RU7] synonym: "p65-interacting inhibitor of NF-kappa-B" EXACT [UniProtKB:Q96RU7] synonym: "SINK" EXACT [UniProtKB:Q96RU7] synonym: "TRB-3" EXACT [UniProtKB:Q96RU7] xref: EMBL:AAH19363.1 xref: EMBL:AAH27484.1 xref: EMBL:AAK58175.1 xref: EMBL:AAP04407.1 xref: EMBL:BAB15597.1 xref: EMBL:BAD96557.1 xref: EMBL:CAB81634.1 xref: EMBL:CAG27047.1 xref: EMBL:CAG33647.1 xref: UniProtKB:Q53GU4 xref: UniProtKB:Q53ZW7 xref: UniProtKB:Q6I9Y9 xref: UniProtKB:Q8TAI6 xref: UniProtKB:Q96RU7 xref: UniProtKB:Q9H5M8 xref: UniProtKB:Q9NUD2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005833 ! TRIB3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0005478 name: INSR_HUMAN def: "Insulin receptor precursor" [UniProtKB:P06213] synonym: "CD220 antigen" EXACT [UniProtKB:P06213] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P06213] synonym: "IR" EXACT [UniProtKB:P06213] xref: EMBL:AAA59174.1 xref: EMBL:AAA59175.1 xref: EMBL:AAA59176.1 xref: EMBL:AAA59177.1 xref: EMBL:AAA59178.1 xref: EMBL:AAA59190.1 xref: EMBL:AAA59452.1 xref: EMBL:AAA86791.1 xref: EMBL:AAC37604.1 xref: EMBL:CAA26096.1 xref: UniProtKB:P06213 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004900 ! INSR_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006286 ! insr-shc1-1 physical interaction relationship: transforms_into CCO:B0012419 ! INSR_HUMAN-Phosphotyrosine992 relationship: transforms_into CCO:B0012420 ! INSR_HUMAN-Phosphotyrosine999 relationship: transforms_into CCO:B0012421 ! INSR_HUMAN-Phosphotyrosine1011 relationship: transforms_into CCO:B0012422 ! INSR_HUMAN-Phosphotyrosine1185 relationship: transforms_into CCO:B0012423 ! INSR_HUMAN-Phosphotyrosine1189 relationship: transforms_into CCO:B0012424 ! INSR_HUMAN-Phosphotyrosine1190 relationship: transforms_into CCO:B0012425 ! INSR_HUMAN-Phosphotyrosine1355 relationship: transforms_into CCO:B0012426 ! INSR_HUMAN-Phosphotyrosine1361 [Term] id: CCO:B0005479 name: TNR6_HUMAN def: "Tumor necrosis factor receptor superfamily member 6 precursor" [UniProtKB:P25445] synonym: "Apo-1 antigen" EXACT [UniProtKB:P25445] synonym: "Apoptosis-mediating surface antigen FAS" EXACT [UniProtKB:P25445] synonym: "CD95 antigen" EXACT [UniProtKB:P25445] synonym: "FASLG receptor" EXACT [UniProtKB:P25445] xref: EMBL:AAA63174.1 xref: EMBL:AAH12479.1 xref: EMBL:AAR08906.1 xref: EMBL:CAA45250.1 xref: EMBL:CAA61473.1 xref: EMBL:CAA88031.1 xref: EMBL:CAA88032.1 xref: EMBL:CAA88033.1 xref: EMBL:CAA94430.1 xref: EMBL:CAA94431.1 xref: UniProtKB:P25445 xref: UniProtKB:Q14292 xref: UniProtKB:Q14293 xref: UniProtKB:Q14294 xref: UniProtKB:Q14295 xref: UniProtKB:Q16652 xref: UniProtKB:Q6SSE9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005805 ! FAS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008341 ! tnfrsf6-rif1 physical interaction [Term] id: CCO:B0005480 name: 1433B_HUMAN def: "14-3-3 protein beta/alpha" [UniProtKB:P31946] synonym: "KCIP-1" EXACT [UniProtKB:P31946] synonym: "Protein 1054" EXACT [UniProtKB:P31946] synonym: "Protein kinase C inhibitor protein 1" EXACT [UniProtKB:P31946] xref: EMBL:AAH01359.1 xref: EMBL:CAA15497.1 xref: EMBL:CAA40621.1 xref: UniProtKB:P31946 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0003992 ! YWHAB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006307 ! abl1-ywhab-1 physical interaction relationship: participates_in CCO:I0007742 ! cdn1b-ywhab-1 physical interaction relationship: transforms_into CCO:B0010364 ! 1433B_HUMAN-N-acetylthreonine2 relationship: transforms_into CCO:B0010365 ! 1433B_HUMAN-Phosphoserine186 [Term] id: CCO:B0005481 name: TBP_HUMAN def: "TATA-box-binding protein" [UniProtKB:P20226] synonym: "TATA sequence-binding protein" EXACT [UniProtKB:P20226] synonym: "TATA-binding factor" EXACT [UniProtKB:P20226] synonym: "TATA-box factor" EXACT [UniProtKB:P20226] synonym: "Transcription initiation factor TFIID TBP subunit" EXACT [UniProtKB:P20226] xref: EMBL:AAA36731.1 xref: EMBL:AAC03409.1 xref: EMBL:CAA20286.1 xref: EMBL:CAA38736.1 xref: UniProtKB:P20226 xref: UniProtKB:Q16845 xref: UniProtKB:Q9UC02 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005744 ! TBP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006298 ! tbp-taf1-2 physical interaction relationship: participates_in CCO:I0006698 ! tp53-tbp1 physical interaction relationship: participates_in CCO:I0006699 ! tp53-tbp-2 physical interaction relationship: participates_in CCO:I0006714 ! tbp-taf1-1 physical interaction relationship: participates_in CCO:I0007734 ! taf1l-tbp-1 physical interaction [Term] id: CCO:B0005482 name: DAPK1_HUMAN def: "Death-associated protein kinase 1" [UniProtKB:P53355] synonym: "DAP kinase 1" EXACT [UniProtKB:P53355] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P53355] xref: EMBL:AAP35581.1 xref: EMBL:CAA53712.1 xref: EMBL:CAH18690.1 xref: UniProtKB:P53355 xref: UniProtKB:Q68CP8 xref: UniProtKB:Q9BTL8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004435 ! DAPK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006299 ! dapk-erk physical interaction relationship: participates_in CCO:I0006300 ! dapk-erk-3 physical interaction relationship: participates_in CCO:I0007551 ! dapk-erk-2 physical interaction relationship: participates_in CCO:I0007858 ! dapk-erk-1 physical interaction relationship: transforms_into CCO:B0011427 ! DAPK1_HUMAN-Phosphoserine308 [Term] id: CCO:B0005483 name: STAU1_HUMAN def: "Double-stranded RNA-binding protein Staufen homolog 1" [UniProtKB:O95793] xref: EMBL:AAD17530.1 xref: EMBL:AAD17531.1 xref: EMBL:AAD17532.1 xref: EMBL:AAD17533.1 xref: EMBL:AAH50432.1 xref: EMBL:AAH95397.1 xref: EMBL:CAB40082.1 xref: EMBL:CAB66536.1 xref: EMBL:CAC14084.1 xref: EMBL:CAC14085.1 xref: UniProtKB:O95793 xref: UniProtKB:Q6GTM4 xref: UniProtKB:Q9H5B4 xref: UniProtKB:Q9H5B5 xref: UniProtKB:Q9Y3Q2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005688 ! STAU1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006301 ! rent1-stau-2 physical interaction relationship: participates_in CCO:I0006715 ! rent1-stau-3 physical interaction relationship: participates_in CCO:I0006716 ! rent1-stau-4 physical interaction relationship: participates_in CCO:I0006848 ! stau-loc84643-1 physical interaction relationship: participates_in CCO:I0007552 ! rent1-stau-1 physical interaction [Term] id: CCO:B0005484 name: HDAC1_HUMAN def: "Histone deacetylase 1" [UniProtKB:Q13547] synonym: "EC 3.5.1.98" EXACT [UniProtKB:Q13547] synonym: "HD1" EXACT [UniProtKB:Q13547] xref: EMBL:AAC50475.1 xref: EMBL:AAH00301.1 xref: EMBL:BAA08909.1 xref: UniProtKB:Q13547 xref: UniProtKB:Q92534 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004786 ! HDAC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006302 ! hcfc1-hdac1-1 physical interaction relationship: participates_in CCO:I0006564 ! tp53-nfya-3 physical interaction relationship: participates_in CCO:I0006565 ! tp53-nfya-4 physical interaction relationship: participates_in CCO:I0006795 ! tp53-hdac1 physical interaction relationship: participates_in CCO:I0006821 ! brms1-hdac1 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: participates_in CCO:I0007189 ! hdac1-brms1 physical interaction relationship: participates_in CCO:I0007309 ! rb1-hdac1 physical interaction relationship: participates_in CCO:I0007460 ! suv39h1-hdac1-3 physical interaction relationship: participates_in CCO:I0007496 ! rb1-e2f1 physical interaction relationship: participates_in CCO:I0007869 ! hdac1-rbbp4-1 physical interaction relationship: participates_in CCO:I0007975 ! suv93h1-hdac1-1 physical interaction relationship: participates_in CCO:I0007976 ! suv93h1-hdac1-2 physical interaction relationship: participates_in CCO:I0008444 ! tpd52l1-hdac1 physical interaction relationship: transforms_into CCO:B0012155 ! HDAC1_HUMAN-Phosphotyrosine221 relationship: transforms_into CCO:B0012156 ! HDAC1_HUMAN-Phosphoserine393 relationship: transforms_into CCO:B0012157 ! HDAC1_HUMAN-Phosphoserine421 relationship: transforms_into CCO:B0012158 ! HDAC1_HUMAN-Phosphoserine423 [Term] id: CCO:B0005485 name: SP1_HUMAN def: "Transcription factor Sp1" [UniProtKB:P08047] xref: EMBL:AAA61154.1 xref: EMBL:AAF67726.1 xref: EMBL:AAF78781.1 xref: EMBL:AAH43224.1 xref: EMBL:AAH62539.1 xref: EMBL:BAB13476.1 xref: EMBL:CAB75345.1 xref: UniProtKB:P08047 xref: UniProtKB:Q86TN8 xref: UniProtKB:Q9H3Q5 xref: UniProtKB:Q9NR51 xref: UniProtKB:Q9NY21 xref: UniProtKB:Q9NYE7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005651 ! SP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006304 ! hcfc1-sp1-1 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: participates_in CCO:I0007355 ! hcfc1-many-2 physical interaction relationship: transforms_into CCO:B0014156 ! SP1_HUMAN-Phosphoserine7 relationship: transforms_into CCO:B0014157 ! SP1_HUMAN-Phosphoserine59 [Term] id: CCO:B0005486 name: HRX_HUMAN def: "Zinc finger protein HRX" [UniProtKB:Q03164] synonym: "ALL-1" EXACT [UniProtKB:Q03164] synonym: "CXXC-type zinc finger protein 7" EXACT [UniProtKB:Q03164] synonym: "Lysine N-methyltransferase 2A" EXACT [UniProtKB:Q03164] synonym: "Trithorax-like protein" EXACT [UniProtKB:Q03164] xref: EMBL:AAA18644.1 xref: EMBL:AAA58669.1 xref: EMBL:AAA92511.1 xref: EMBL:AAB28545.1 xref: EMBL:AAB34770.1 xref: EMBL:AAG26332.2 xref: EMBL:AAQ63624.1 xref: EMBL:BAA03407.1 xref: EMBL:CAA58584.1 xref: EMBL:CAA93625.1 xref: UniProtKB:Q03164 xref: UniProtKB:Q13743 xref: UniProtKB:Q13744 xref: UniProtKB:Q14845 xref: UniProtKB:Q16364 xref: UniProtKB:Q6UBD1 xref: UniProtKB:Q9UMA3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004829 ! MLL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006305 ! mll-hcfc2-2 physical interaction relationship: participates_in CCO:I0008569 ! mll-hcfc2-1 physical interaction relationship: transforms_into CCO:B0012255 ! HRX_HUMAN-Phosphoserine279 relationship: transforms_into CCO:B0012256 ! HRX_HUMAN-Phosphothreonine337 relationship: transforms_into CCO:B0012257 ! HRX_HUMAN-Phosphoserine1837 relationship: transforms_into CCO:B0012258 ! HRX_HUMAN-Phosphoserine2151 relationship: transforms_into CCO:B0012259 ! HRX_HUMAN-Phosphoserine2866 relationship: transforms_into CCO:B0012260 ! HRX_HUMAN-Phosphothreonine2940 relationship: transforms_into CCO:B0012261 ! HRX_HUMAN-Phosphoserine3036 relationship: transforms_into CCO:B0012262 ! HRX_HUMAN-Phosphoserine3511 [Term] id: CCO:B0005488 name: 1433E_HUMAN def: "14-3-3 protein epsilon" [UniProtKB:P62258] synonym: "14-3-3E" EXACT [UniProtKB:P62258] xref: EMBL:AAA75301.1 xref: EMBL:AAC50175.1 xref: EMBL:AAC50625.1 xref: EMBL:AAC50710.1 xref: EMBL:AAD00026.1 xref: EMBL:AAH00179.1 xref: EMBL:AAH01440.1 xref: EMBL:AAP35825.1 xref: EMBL:BAA32538.1 xref: EMBL:EAW90628.1 xref: UniProtKB:P29360 xref: UniProtKB:P42655 xref: UniProtKB:P62258 xref: UniProtKB:Q53XZ5 xref: UniProtKB:Q63631 xref: UniProtKB:Q7M4R4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0003993 ! YWHAE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006307 ! abl1-ywhab-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007180 ! snf1lk-ywhaz-1 physical interaction relationship: participates_in CCO:I0007743 ! cdn1b-ywhae-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0010366 ! 1433E_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0010367 ! 1433E_HUMAN-Phosphoserine210 [Term] id: CCO:B0005489 name: 1433G_HUMAN def: "14-3-3 protein gamma" [UniProtKB:P61981] synonym: "KCIP-1" EXACT [UniProtKB:P61981] synonym: "Protein kinase C inhibitor protein 1" EXACT [UniProtKB:P61981] xref: EMBL:AAD48408.1 xref: EMBL:AAH20963.1 xref: EMBL:BAA85184.1 xref: EMBL:CAG46702.1 xref: EMBL:CAG46723.1 xref: UniProtKB:O70457 xref: UniProtKB:P35214 xref: UniProtKB:P61981 xref: UniProtKB:Q6FH52 xref: UniProtKB:Q9UDP2 xref: UniProtKB:Q9UN99 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0003995 ! YWHAG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006307 ! abl1-ywhab-1 physical interaction relationship: participates_in CCO:I0007744 ! cdn1b-ywhag-1 physical interaction relationship: transforms_into CCO:B0010369 ! 1433G_HUMAN-N-acetylvaline2 relationship: transforms_into CCO:B0031285 ! 1433G_HUMAN-Phosphotyrosine117 [Term] id: CCO:B0005490 name: 1433F_HUMAN def: "14-3-3 protein eta" [UniProtKB:Q04917] synonym: "Protein AS1" EXACT [UniProtKB:Q04917] xref: EMBL:AAA35483.1 xref: EMBL:AAB36036.1 xref: EMBL:AAH03047.1 xref: EMBL:BAA11418.1 xref: EMBL:CAA40620.1 xref: EMBL:CAA55017.1 xref: EMBL:CAA56676.1 xref: EMBL:CAB05112.1 xref: EMBL:CAG30498.1 xref: UniProtKB:Q04917 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0003994 ! YWHAH_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006307 ! abl1-ywhab-1 physical interaction relationship: participates_in CCO:I0007213 ! pard6a-ywhah-1 physical interaction relationship: participates_in CCO:I0007215 ! pard6b-ywhah-1 physical interaction relationship: participates_in CCO:I0007219 ! ywhah-pard3-1 physical interaction relationship: participates_in CCO:I0007220 ! pard3-ywhah-1 physical interaction relationship: participates_in CCO:I0007269 ! nek1-ywhah-1 physical interaction relationship: transforms_into CCO:B0010368 ! 1433F_HUMAN-N-acetylglycine2 relationship: transforms_into CCO:B0031284 ! 1433F_HUMAN-Phosphotyrosine117 [Term] id: CCO:B0005491 name: RBX1_HUMAN def: "RING-box protein 1" [UniProtKB:P62877] synonym: "Protein ZYP" EXACT [UniProtKB:P62877] synonym: "Rbx1" EXACT [UniProtKB:P62877] synonym: "Regulator of cullins 1" EXACT [UniProtKB:P62877] synonym: "RING finger protein 75" EXACT [UniProtKB:P62877] xref: EMBL:AAD29715.1 xref: EMBL:AAD30146.1 xref: EMBL:AAH01466.1 xref: EMBL:AAH17370.2 xref: EMBL:AAM21718.1 xref: EMBL:CAB62925.1 xref: EMBL:CAG30446.1 xref: UniProtKB:P62877 xref: UniProtKB:Q8N6Z8 xref: UniProtKB:Q9D1S2 xref: UniProtKB:Q9WUK9 xref: UniProtKB:Q9Y254 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005453 ! RBX1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006310 ! cul1-cand1-6 physical interaction relationship: participates_in CCO:I0006682 ! cul4b-tip120a-1 physical interaction relationship: participates_in CCO:I0006693 ! cul1-tip120a-3 physical interaction relationship: participates_in CCO:I0006796 ! cul1-rbx1-6 direct interaction relationship: participates_in CCO:I0006797 ! cul1-cul1-7 physical interaction relationship: participates_in CCO:I0006866 ! cul1-cand1-7 physical interaction relationship: participates_in CCO:I0006867 ! cul1-rbx1-5 physical interaction relationship: participates_in CCO:I0007109 ! cul1-cand1-2 physical interaction relationship: participates_in CCO:I0007114 ! cul1-cand1-8 physical interaction relationship: participates_in CCO:I0007504 ! cand1-cul1-5 physical interaction relationship: participates_in CCO:I0007733 ! skp2-cks1-4 physical interaction relationship: transforms_into CCO:B0041339 ! RBX1_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005492 name: GPSM2_HUMAN def: "G-protein-signaling modulator 2" [UniProtKB:P81274] synonym: "Mosaic protein LGN" EXACT [UniProtKB:P81274] xref: EMBL:AAB40385.1 xref: EMBL:AAH27732.1 xref: EMBL:AAN01266.1 xref: UniProtKB:P81274 xref: UniProtKB:Q8N0Z5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004724 ! GPSM2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006311 ! numa1-gpsm2-1 physical interaction relationship: participates_in CCO:I0006312 ! numa1-gnai1-1 physical interaction relationship: participates_in CCO:I0006967 ! gnai1-gpsm2-3 physical interaction relationship: participates_in CCO:I0006968 ! gpsm2-numa1-1 physical interaction relationship: participates_in CCO:I0007255 ! gpsm2-numa1-3 physical interaction relationship: participates_in CCO:I0007421 ! gpsm2-numa1-2 physical interaction relationship: participates_in CCO:I0007750 ! gpsm2-numa1-4 physical interaction relationship: transforms_into CCO:B0011968 ! GPSM2_HUMAN-Phosphoserine125 relationship: transforms_into CCO:B0011969 ! GPSM2_HUMAN-Phosphoserine345 relationship: transforms_into CCO:B0011970 ! GPSM2_HUMAN-Phosphoserine401 relationship: transforms_into CCO:B0011971 ! GPSM2_HUMAN-Phosphoserine494 relationship: transforms_into CCO:B0011972 ! GPSM2_HUMAN-Phosphoserine600 [Term] id: CCO:B0005493 name: GNAI1_HUMAN def: "Guanine nucleotide-binding protein G(i), alpha-1 subunit" [UniProtKB:P63096] synonym: "Adenylate cyclase-inhibiting G alpha protein" EXACT [UniProtKB:P63096] xref: EMBL:AAA35893.1 xref: EMBL:AAA52581.1 xref: EMBL:AAC09361.1 xref: EMBL:AAH26326.1 xref: EMBL:AAM12619.1 xref: EMBL:AAV38580.1 xref: EMBL:CAB43212.2 xref: UniProtKB:P04898 xref: UniProtKB:P11015 xref: UniProtKB:P31871 xref: UniProtKB:P63096 xref: UniProtKB:Q5U074 xref: UniProtKB:Q8TAN5 xref: UniProtKB:Q9UGA4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004709 ! GNAI1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006312 ! numa1-gnai1-1 physical interaction relationship: participates_in CCO:I0006966 ! gnai1-numa1-1 physical interaction relationship: participates_in CCO:I0006967 ! gnai1-gpsm2-3 physical interaction relationship: participates_in CCO:I0007747 ! gnai1-gpsm2-2 physical interaction relationship: transforms_into CCO:B0011949 ! GNAI1_HUMAN-ADP-ribosylarginine178 relationship: transforms_into CCO:B0011950 ! GNAI1_HUMAN-ADP-ribosylcysteine351 [Term] id: CCO:B0005494 name: LSM7_HUMAN def: "U6 snRNA-associated Sm-like protein LSm7" [UniProtKB:Q9UK45] xref: EMBL:AAD56231.1 xref: EMBL:AAG45442.1 xref: EMBL:AAH18621.1 xref: UniProtKB:Q9UK45 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004994 ! LSM7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006314 ! tacc1-lsm7-2 physical interaction [Term] id: CCO:B0005495 name: RUXG_HUMAN def: "Small nuclear ribonucleoprotein G" [UniProtKB:P62308] synonym: "Sm protein G" EXACT [UniProtKB:P62308] synonym: "Sm-G" EXACT [UniProtKB:P62308] synonym: "SmG" EXACT [UniProtKB:P62308] synonym: "snRNP-G" EXACT [UniProtKB:P62308] xref: EMBL:AAH00070.1 xref: EMBL:AAH22432.1 xref: EMBL:AAH66302.1 xref: EMBL:AAH70166.1 xref: EMBL:CAA59689.1 xref: UniProtKB:P62308 xref: UniProtKB:Q15357 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005550 ! SNRPG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006315 ! tacc1-snrpg-2 physical interaction [Term] id: CCO:B0005496 name: TDRD7_HUMAN def: "Tudor domain-containing protein 7" [UniProtKB:Q8NHU6] synonym: "PCTAIRE2-binding protein" EXACT [UniProtKB:Q8NHU6] synonym: "Trap" EXACT [UniProtKB:Q8NHU6] synonym: "Tudor repeat associator with PCTAIRE 2" EXACT [UniProtKB:Q8NHU6] xref: EMBL:AAH28694.1 xref: EMBL:BAA76379.1 xref: EMBL:CAB59271.1 xref: EMBL:CAH71605.1 xref: EMBL:CAI14933.1 xref: UniProtKB:A6NCI6 xref: UniProtKB:Q5VV27 xref: UniProtKB:Q8NHU6 xref: UniProtKB:Q96JT1 xref: UniProtKB:Q9UFF0 xref: UniProtKB:Q9Y2M3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005757 ! TDRD7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006316 ! tacc1-tdrd7-6 physical interaction relationship: participates_in CCO:I0006969 ! tacc1-tdrd7-8 physical interaction relationship: participates_in CCO:I0007354 ! tacc1-tdrd7-1 physical interaction relationship: participates_in CCO:I0007567 ! tacc1-tdrd7-7 physical interaction [Term] id: CCO:B0005497 name: ARID2_HUMAN def: "AT-rich interactive domain-containing protein 2" [UniProtKB:Q68CP9] synonym: "ARID domain-containing protein 2" EXACT [UniProtKB:Q68CP9] synonym: "BAF200" EXACT [UniProtKB:Q68CP9] synonym: "BRG1-associated factor 200" EXACT [UniProtKB:Q68CP9] synonym: "Zinc finger protein with activation potential" EXACT [UniProtKB:Q68CP9] synonym: "Zipzap/p200" EXACT [UniProtKB:Q68CP9] xref: EMBL:AAH90062.1 xref: EMBL:AAU20329.2 xref: EMBL:AAZ74794.1 xref: EMBL:BAB13383.1 xref: EMBL:BAB55320.1 xref: EMBL:BAC87171.1 xref: EMBL:CAD91164.1 xref: EMBL:CAD97878.1 xref: EMBL:CAH18689.1 xref: UniProtKB:Q15KG9 xref: UniProtKB:Q5EB51 xref: UniProtKB:Q645I3 xref: UniProtKB:Q68CP9 xref: UniProtKB:Q6ZRY5 xref: UniProtKB:Q7Z3I5 xref: UniProtKB:Q86T28 xref: UniProtKB:Q96SJ6 xref: UniProtKB:Q9HCL5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004094 ! ARID2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006322 ! pb1-arid2-4 physical interaction relationship: participates_in CCO:I0006729 ! pb1-arid2-2 physical interaction relationship: participates_in CCO:I0007258 ! smarcb1-arid2-1 physical interaction relationship: participates_in CCO:I0007259 ! arid2-pb1-1 physical interaction relationship: participates_in CCO:I0007356 ! pb1-arid2-3 physical interaction relationship: participates_in CCO:I0007961 ! pb1-arid2-1 physical interaction [Term] id: CCO:B0005498 name: CREB3_HUMAN def: "Cyclic AMP-responsive element-binding protein 3" [UniProtKB:O43889] synonym: "Luman protein" EXACT [UniProtKB:O43889] synonym: "Transcription factor LZIP-alpha" EXACT [UniProtKB:O43889] xref: EMBL:AAB69652.1 xref: EMBL:AAB84166.1 xref: EMBL:AAC04325.1 xref: EMBL:AAD09210.1 xref: EMBL:AAG43527.1 xref: EMBL:AAG43528.1 xref: EMBL:AAH09402.1 xref: EMBL:AAH10158.1 xref: UniProtKB:O14671 xref: UniProtKB:O14919 xref: UniProtKB:O43889 xref: UniProtKB:Q96GK8 xref: UniProtKB:Q9H2W3 xref: UniProtKB:Q9UE77 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004396 ! CREB3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006323 ! hcfc1-creb3-2 physical interaction relationship: participates_in CCO:I0007264 ! hcfc1-creb3-3 direct interaction relationship: participates_in CCO:I0007266 ! hcfc1-creb3-4 direct interaction relationship: participates_in CCO:I0007752 ! hcfc1-creb3-1 physical interaction relationship: participates_in CCO:I0007755 ! hcfc1-zf-5 physical interaction [Term] id: CCO:B0005499 name: MAST3_HUMAN def: "Microtubule-associated serine/threonine-protein kinase 3" [UniProtKB:O60307] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O60307] xref: EMBL:AAC62830.1 xref: EMBL:AAD22670.1 xref: EMBL:BAA25487.1 xref: UniProtKB:O60307 xref: UniProtKB:Q7LDZ8 xref: UniProtKB:Q9UPI0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005029 ! MAST3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006324 ! pten-mast3-3 phosphorylation relationship: participates_in CCO:I0007572 ! pten-mast3-2 physical interaction relationship: participates_in CCO:I0007757 ! pten-mast3-1 physical interaction relationship: transforms_into CCO:B0012778 ! MAST3_HUMAN-Phosphoserine1223 relationship: transforms_into CCO:B0012779 ! MAST3_HUMAN-Phosphoserine1273 [Term] id: CCO:B0005500 name: RFA2_HUMAN def: "Replication protein A 32 kDa subunit" [UniProtKB:P15927] synonym: "p32" EXACT [UniProtKB:P15927] synonym: "p34" EXACT [UniProtKB:P15927] synonym: "Replication factor A protein 2" EXACT [UniProtKB:P15927] synonym: "RF-A" EXACT [UniProtKB:P15927] synonym: "RP-A" EXACT [UniProtKB:P15927] xref: EMBL:AAA36560.1 xref: EMBL:AAH01630.1 xref: EMBL:AAH12157.1 xref: EMBL:AAH21257.1 xref: EMBL:AAX84514.1 xref: EMBL:CAG29344.1 xref: EMBL:CAI21775.1 xref: EMBL:CAI21777.1 xref: EMBL:CAI21778.1 xref: UniProtKB:P15927 xref: UniProtKB:Q52II0 xref: UniProtKB:Q5TEI9 xref: UniProtKB:Q5TEJ5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005470 ! RPA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007422 ! blm-c9orf76-2 physical interaction relationship: participates_in CCO:I0007749 ! blm-c9orf76-1 physical interaction relationship: participates_in CCO:I0007990 ! rpa2-rif1 physical interaction relationship: transforms_into CCO:B0013823 ! RFA2_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0013824 ! RFA2_HUMAN-Phosphothreonine21 relationship: transforms_into CCO:B0013825 ! RFA2_HUMAN-Phosphoserine29 relationship: transforms_into CCO:B0013826 ! RFA2_HUMAN-Phosphoserine33 [Term] id: CCO:B0005501 name: RFA3_HUMAN def: "Replication protein A 14 kDa subunit" [UniProtKB:P35244] synonym: "p14" EXACT [UniProtKB:P35244] synonym: "Replication factor A protein 3" EXACT [UniProtKB:P35244] synonym: "RF-A" EXACT [UniProtKB:P35244] synonym: "RP-A" EXACT [UniProtKB:P35244] xref: EMBL:AAA58350.1 xref: EMBL:AAH05264.1 xref: EMBL:AAH09868.1 xref: EMBL:AAP35984.1 xref: EMBL:AAQ96878.1 xref: EMBL:AAX84517.1 xref: UniProtKB:P35244 xref: UniProtKB:Q549U6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005471 ! RPA3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007749 ! blm-c9orf76-1 physical interaction [Term] id: CCO:B0005502 name: BLM_HUMAN def: "Bloom syndrome protein" [UniProtKB:P54132] synonym: "DNA helicase, RecQ-like type 2" EXACT [UniProtKB:P54132] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P54132] synonym: "RecQ protein-like 3" EXACT [UniProtKB:P54132] xref: EMBL:AAA87850.1 xref: EMBL:AAH93622.1 xref: EMBL:AAI01568.1 xref: EMBL:AAI15031.1 xref: EMBL:AAI15033.1 xref: EMBL:AAW62255.1 xref: UniProtKB:P54132 xref: UniProtKB:Q52M96 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004168 ! BLM_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006326 ! blm-terf1-6 direct interaction relationship: participates_in CCO:I0006538 ! blm-terf2-4 colocalization relationship: participates_in CCO:I0006879 ! blm-terf1-7 direct interaction relationship: participates_in CCO:I0006880 ! blm-terf1-8 direct interaction relationship: participates_in CCO:I0006881 ! blm-terf2-9 direct interaction relationship: participates_in CCO:I0006882 ! blm-terf2-10 direct interaction relationship: participates_in CCO:I0007283 ! blm-terf2-1 physical interaction relationship: participates_in CCO:I0007358 ! blm-terf2-2 physical interaction relationship: participates_in CCO:I0007359 ! blm-terf2-5 colocalization relationship: participates_in CCO:I0007422 ! blm-c9orf76-2 physical interaction relationship: participates_in CCO:I0007427 ! c9orf76-blm-2 physical interaction relationship: participates_in CCO:I0007574 ! blm-terf2-3 direct interaction relationship: participates_in CCO:I0007748 ! c9orf76-blm-1 physical interaction relationship: participates_in CCO:I0007749 ! blm-c9orf76-1 physical interaction relationship: participates_in CCO:I0007762 ! blm-rpa1-1 physical interaction relationship: participates_in CCO:I0007763 ! blm-rpa1-2 physical interaction relationship: participates_in CCO:I0007768 ! blm-terf2-6 direct interaction relationship: participates_in CCO:I0008561 ! c9orf76-blm-4 colocalization relationship: participates_in CCO:I0008562 ! blm-fen1-2 physical interaction relationship: participates_in CCO:I0008563 ! blm-fen1-4 physical interaction relationship: participates_in CCO:I0008565 ! c9orf76-blm-3 physical interaction relationship: participates_in CCO:I0008566 ! wrn-blm-11 physical interaction relationship: participates_in CCO:I0008570 ! wrn-blm-4 colocalization relationship: participates_in CCO:I0008571 ! wrn-blm-6 direct interaction relationship: participates_in CCO:I0008572 ! wrn-blm-7 direct interaction relationship: participates_in CCO:I0008573 ! wrn-blm-9 direct interaction relationship: participates_in CCO:I0008574 ! wrn-blm-2 colocalization relationship: participates_in CCO:I0008575 ! wrn-blm-5 physical interaction relationship: participates_in CCO:I0008578 ! wrn-blm-3 colocalization relationship: participates_in CCO:I0008580 ! blm-fen1-1 direct interaction relationship: participates_in CCO:I0008583 ! blm-fen1-3 direct interaction relationship: participates_in CCO:I0008584 ! wrn-blm-1 direct interaction relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000015 ! G2 phase of mitotic cell cycle relationship: participates_in CCO:P0000185 ! G2/M transition DNA damage checkpoint relationship: transforms_into CCO:B0010800 ! BLM_HUMAN-Phosphoserine419 relationship: transforms_into CCO:B0010801 ! BLM_HUMAN-Phosphoserine422 relationship: transforms_into CCO:B0010802 ! BLM_HUMAN-Phosphoserine480 relationship: transforms_into CCO:B0010803 ! BLM_HUMAN-Phosphoserine499 relationship: transforms_into CCO:B0010804 ! BLM_HUMAN-Phosphothreonine508 relationship: transforms_into CCO:B0010805 ! BLM_HUMAN-Phosphoserine1296 [Term] id: CCO:B0005503 name: POTE1_HUMAN def: "Protection of telomeres protein 1" [UniProtKB:Q9NUX5] synonym: "hPot1" EXACT [UniProtKB:Q9NUX5] synonym: "POT1-like telomere end-binding protein" EXACT [UniProtKB:Q9NUX5] xref: EMBL:AAD08852.1 xref: EMBL:AAH02923.1 xref: EMBL:BAA91568.1 xref: EMBL:BAA91988.1 xref: EMBL:BAB14110.1 xref: EMBL:BAB15404.1 xref: EMBL:CAB43281.1 xref: UniProtKB:O95018 xref: UniProtKB:Q9H662 xref: UniProtKB:Q9NUX5 xref: UniProtKB:Q9NW19 xref: UniProtKB:Q9UG95 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005355 ! POT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006327 ! pot1-terf2 physical interaction relationship: participates_in CCO:I0006330 ! terf2-tinf2 physical interaction relationship: participates_in CCO:I0007893 ! pot1-terf2-1 physical interaction [Term] id: CCO:B0005504 name: ACD_HUMAN def: "Adrenocortical dysplasia protein homolog" [UniProtKB:Q96AP0] synonym: "POT1 and TIN2-interacting protein" EXACT [UniProtKB:Q96AP0] xref: EMBL:AAH16904.1 xref: EMBL:AAS80318.1 xref: EMBL:AAX82621.1 xref: EMBL:BAB14658.1 xref: UniProtKB:Q562H5 xref: UniProtKB:Q96AP0 xref: UniProtKB:Q9H8F9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004015 ! ACD_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006328 ! acd-terf2 physical interaction relationship: participates_in CCO:I0007893 ! pot1-terf2-1 physical interaction [Term] id: CCO:B0005505 name: TE2IP_HUMAN def: "Telomeric repeat-binding factor 2-interacting protein 1" [UniProtKB:Q9NYB0] synonym: "hRap1" EXACT [UniProtKB:Q9NYB0] synonym: "TRF2-interacting telomeric protein Rap1" EXACT [UniProtKB:Q9NYB0] xref: EMBL:AAF72711.1 xref: EMBL:AAH04465.1 xref: EMBL:AAH05841.1 xref: EMBL:AAH22428.1 xref: EMBL:AAH78171.1 xref: EMBL:AAL55783.1 xref: EMBL:BAA91317.1 xref: UniProtKB:Q8WYZ3 xref: UniProtKB:Q9NWR2 xref: UniProtKB:Q9NYB0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005758 ! TERF2IP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006329 ! rap1-terf2-2 physical interaction relationship: participates_in CCO:I0006331 ! rap1-terf2-3 physical interaction relationship: participates_in CCO:I0007131 ! terf2ip-rad50 physical interaction relationship: participates_in CCO:I0007893 ! pot1-terf2-1 physical interaction relationship: transforms_into CCO:B0014328 ! TE2IP_HUMAN-Phosphoserine154 relationship: transforms_into CCO:B0014329 ! TE2IP_HUMAN-Phosphoserine156 relationship: transforms_into CCO:B0014330 ! TE2IP_HUMAN-Phosphoserine203 relationship: transforms_into CCO:B0014331 ! TE2IP_HUMAN-Phosphoserine206 [Term] id: CCO:B0005507 name: PRI1_HUMAN def: "DNA primase small subunit" [UniProtKB:P49642] synonym: "DNA primase 49 kDa subunit" EXACT [UniProtKB:P49642] synonym: "EC 2.7.7.-" EXACT [UniProtKB:P49642] synonym: "p49" EXACT [UniProtKB:P49642] xref: EMBL:AAC51726.1 xref: EMBL:AAH05266.1 xref: EMBL:CAA52377.1 xref: UniProtKB:P49642 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005375 ! PRIM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006337 ! pola-pola2-6 physical interaction relationship: participates_in CCO:I0006338 ! pola-pri1-1 physical interaction relationship: participates_in CCO:I0007909 ! pol-prim_human physical interaction [Term] id: CCO:B0005508 name: PRI2_HUMAN def: "DNA primase large subunit" [UniProtKB:P49643] synonym: "DNA primase 58 kDa subunit" EXACT [UniProtKB:P49643] synonym: "EC 2.7.7.-" EXACT [UniProtKB:P49643] synonym: "p58" EXACT [UniProtKB:P49643] xref: EMBL:AAH17833.1 xref: EMBL:AAH64931.1 xref: EMBL:CAA52378.1 xref: EMBL:CAH73686.1 xref: EMBL:CAI20534.1 xref: UniProtKB:P49643 xref: UniProtKB:Q53FJ8 xref: UniProtKB:Q6P1Q7 xref: UniProtKB:Q8WVL2 xref: UniProtKB:Q9H413 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006367 ! PRIM2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006337 ! pola-pola2-6 physical interaction relationship: participates_in CCO:I0006338 ! pola-pri1-1 physical interaction relationship: participates_in CCO:I0007909 ! pol-prim_human physical interaction relationship: transforms_into CCO:B0013612 ! PRI2_HUMAN-Phosphotyrosine381 [Term] id: CCO:B0005509 name: DPOA2_HUMAN def: "DNA polymerase subunit alpha B" [UniProtKB:Q14181] synonym: "DNA polymerase alpha 70 kDa subunit" EXACT [UniProtKB:Q14181] xref: EMBL:AAA16459.1 xref: EMBL:AAH01347.1 xref: EMBL:AAH02990.1 xref: EMBL:CAG33018.1 xref: UniProtKB:Q14181 xref: UniProtKB:Q9BPV3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004500 ! POLA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006337 ! pola-pola2-6 physical interaction relationship: participates_in CCO:I0007909 ! pol-prim_human physical interaction relationship: transforms_into CCO:B0011568 ! DPOA2_HUMAN-Phosphothreonine127 relationship: transforms_into CCO:B0011569 ! DPOA2_HUMAN-Phosphothreonine130 relationship: transforms_into CCO:B0011570 ! DPOA2_HUMAN-Phosphoserine141 relationship: transforms_into CCO:B0011571 ! DPOA2_HUMAN-Phosphoserine152 [Term] id: CCO:B0005510 name: MBD1_HUMAN def: "Methyl-CpG-binding domain protein 1" [UniProtKB:Q9UIS9] synonym: "CXXC-type zinc finger protein 3" EXACT [UniProtKB:Q9UIS9] synonym: "Methyl-CpG-binding protein MBD1" EXACT [UniProtKB:Q9UIS9] synonym: "Protein containing methyl-CpG-binding domain 1" EXACT [UniProtKB:Q9UIS9] xref: EMBL:AAC68870.1 xref: EMBL:AAD50371.1 xref: EMBL:AAD51442.1 xref: EMBL:AAD51443.1 xref: EMBL:AAD51444.1 xref: EMBL:AAD51445.1 xref: EMBL:AAH33242.1 xref: EMBL:ABP02056.1 xref: EMBL:CAA71735.1 xref: EMBL:CAD92308.1 xref: UniProtKB:A4UTZ0 xref: UniProtKB:O15248 xref: UniProtKB:O95241 xref: UniProtKB:Q7Z7B5 xref: UniProtKB:Q8N4W4 xref: UniProtKB:Q9UIS9 xref: UniProtKB:Q9UNZ6 xref: UniProtKB:Q9UNZ7 xref: UniProtKB:Q9UNZ8 xref: UniProtKB:Q9UNZ9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005034 ! MBD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006904 ! mbde-suv93h1-1 physical interaction relationship: participates_in CCO:I0006905 ! suv93h1-mbde-1 physical interaction relationship: participates_in CCO:I0006906 ! suv93h1-mbd1-4 colocalization relationship: participates_in CCO:I0007972 ! mbde-suv93h1-2 physical interaction relationship: participates_in CCO:I0007973 ! suv93h1-mbde-2 physical interaction relationship: transforms_into CCO:B0012800 ! MBD1_HUMAN-Phosphotyrosine52 relationship: transforms_into CCO:B0012801 ! MBD1_HUMAN-Phosphoserine295 relationship: transforms_into CCO:B0012802 ! MBD1_HUMAN-Phosphothreonine301 [Term] id: CCO:B0005511 name: TLE1_HUMAN def: "Transducin-like enhancer protein 1" [UniProtKB:Q04724] synonym: "E(Sp1) homolog" EXACT [UniProtKB:Q04724] synonym: "ESG1" EXACT [UniProtKB:Q04724] xref: EMBL:AAA61192.1 xref: EMBL:AAH10100.1 xref: EMBL:AAH15747.1 xref: EMBL:CAI12595.1 xref: EMBL:CAI14977.1 xref: UniProtKB:Q04724 xref: UniProtKB:Q5T3G4 xref: UniProtKB:Q969V9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005788 ! TLE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006341 ! aml2-tle1-1 direct interaction relationship: participates_in CCO:I0006551 ! aml2-tle1-2 physical interaction relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction relationship: participates_in CCO:I0007292 ! tle1-aml2-1 physical interaction relationship: participates_in CCO:I0008022 ! mphosph6-tle1 physical interaction relationship: participates_in CCO:I0008084 ! cdkn2c-tle1 physical interaction relationship: participates_in CCO:I0008222 ! dleu1-tle1 physical interaction relationship: transforms_into CCO:B0014389 ! TLE1_HUMAN-Phosphoserine239 relationship: transforms_into CCO:B0014390 ! TLE1_HUMAN-Phosphoserine259 relationship: transforms_into CCO:B0014391 ! TLE1_HUMAN-Phosphoserine263 relationship: transforms_into CCO:B0014392 ! TLE1_HUMAN-Phosphoserine267 relationship: transforms_into CCO:B0014393 ! TLE1_HUMAN-Phosphoserine284 [Term] id: CCO:B0005512 name: AKT1_HUMAN def: "RAC-alpha serine/threonine-protein kinase" [UniProtKB:P31749] synonym: "C-AKT" EXACT [UniProtKB:P31749] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P31749] synonym: "PKB" EXACT [UniProtKB:P31749] synonym: "Protein kinase B" EXACT [UniProtKB:P31749] synonym: "RAC-PK-alpha" EXACT [UniProtKB:P31749] xref: EMBL:AAA36539.1 xref: EMBL:AAH00479.1 xref: EMBL:AAH84538.1 xref: EMBL:AAL55732.1 xref: EMBL:CAA43372.1 xref: UniProtKB:P31749 xref: UniProtKB:Q9BWB6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004045 ! AKT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006342 ! bcl10-akt1-3 physical interaction relationship: participates_in CCO:I0007374 ! bcl10-akt1-4 physical interaction relationship: participates_in CCO:I0007396 ! cdc37-hsp90 physical interaction relationship: participates_in CCO:I0007397 ! cdc37-akt1 physical interaction relationship: participates_in CCO:I0007795 ! bcl10-akt1-1 physical interaction relationship: participates_in CCO:I0007796 ! bcl10-akt1-2 physical interaction relationship: transforms_into CCO:B0010487 ! AKT1_HUMAN-Phosphoserine124 relationship: transforms_into CCO:B0010488 ! AKT1_HUMAN-Phosphoserine126 relationship: transforms_into CCO:B0010489 ! AKT1_HUMAN-Phosphoserine129 relationship: transforms_into CCO:B0010490 ! AKT1_HUMAN-Phosphothreonine308 relationship: transforms_into CCO:B0010491 ! AKT1_HUMAN-Phosphoserine473 relationship: transforms_into CCO:B0010492 ! AKT1_HUMAN-Phosphotyrosine474 [Term] id: CCO:B0005513 name: BCL3_HUMAN def: "B-cell lymphoma 3-encoded protein" [UniProtKB:P20749] synonym: "Protein Bcl-3" EXACT [UniProtKB:P20749] xref: EMBL:AAA51815.1 xref: EMBL:AAA51816.1 xref: EMBL:AAC51348.1 xref: EMBL:AAH64993.1 xref: UniProtKB:P20749 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004152 ! BCL3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006343 ! bcl10-bcl3-3 physical interaction relationship: participates_in CCO:I0007797 ! bcl10-bcl3-1 physical interaction relationship: participates_in CCO:I0007798 ! bcl10-bcl3-2 physical interaction relationship: transforms_into CCO:B0041126 ! BCL3_HUMAN-Phosphoserine394 relationship: transforms_into CCO:B0041127 ! BCL3_HUMAN-Phosphoserine398 [Term] id: CCO:B0005514 name: CEBPB_HUMAN def: "CCAAT/enhancer-binding protein beta" [UniProtKB:P17676] synonym: "C/EBP beta" EXACT [UniProtKB:P17676] synonym: "Nuclear factor NF-IL6" EXACT [UniProtKB:P17676] synonym: "Transcription factor 5" EXACT [UniProtKB:P17676] xref: EMBL:AAH07538.1 xref: EMBL:AAH21931.1 xref: EMBL:AAL55792.1 xref: EMBL:AAN86350.1 xref: EMBL:CAA36794.1 xref: EMBL:CAC14276.1 xref: UniProtKB:P17676 xref: UniProtKB:Q96IH2 xref: UniProtKB:Q9H4Z5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004317 ! CEBPB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006344 ! tp53-lap-2 colocalization relationship: participates_in CCO:I0006554 ! tp53-lip physical interaction relationship: participates_in CCO:I0006555 ! tp53-cebpb physical interaction relationship: participates_in CCO:I0007451 ! tp53-lap-1 physical interaction [Term] id: CCO:B0005515 name: 2A5D_HUMAN def: "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform" [UniProtKB:Q14738] synonym: "PP2A, B subunit, B' delta isoform" EXACT [UniProtKB:Q14738] synonym: "PP2A, B subunit, B56 delta isoform" EXACT [UniProtKB:Q14738] synonym: "PP2A, B subunit, PR61 delta isoform" EXACT [UniProtKB:Q14738] synonym: "PP2A, B subunit, R5 delta isoform" EXACT [UniProtKB:Q14738] xref: EMBL:AAB69751.1 xref: EMBL:AAH01095.1 xref: EMBL:AAH01175.1 xref: EMBL:AAH10692.1 xref: EMBL:BAA11372.1 xref: EMBL:BAA20381.1 xref: EMBL:BAA20382.1 xref: UniProtKB:O00494 xref: UniProtKB:O00696 xref: UniProtKB:Q14738 xref: UniProtKB:Q15171 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004000 ! PPP2R5D_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006347 ! ppp2r5d-sgol1-1 physical interaction relationship: participates_in CCO:I0006353 ! sgol1-pp2r1b-ppp2r5a physical interaction relationship: participates_in CCO:I0007274 ! nek1-ppp2r5d-1 physical interaction relationship: participates_in CCO:I0007278 ! nek1-tsc2-3 physical interaction relationship: participates_in CCO:I0007513 ! ppp2r5d-cdc25c-1 physical interaction relationship: transforms_into CCO:B0010376 ! 2A5D_HUMAN-Phosphoserine598 relationship: transforms_into CCO:B0035967 ! 2A5D_HUMAN-Phosphothreonine553 [Term] id: CCO:B0005516 name: 2A5A_HUMAN def: "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform" [UniProtKB:Q15172] synonym: "PP2A, B subunit, B' alpha isoform" EXACT [UniProtKB:Q15172] synonym: "PP2A, B subunit, B56 alpha isoform" EXACT [UniProtKB:Q15172] synonym: "PP2A, B subunit, PR61 alpha isoform" EXACT [UniProtKB:Q15172] synonym: "PP2A, B subunit, R5 alpha isoform" EXACT [UniProtKB:Q15172] xref: EMBL:AAC37601.1 xref: EMBL:AAH22474.1 xref: EMBL:AAI10884.1 xref: EMBL:CAH71821.1 xref: EMBL:CAH73229.1 xref: UniProtKB:Q15172 xref: UniProtKB:Q2NL72 xref: UniProtKB:Q5VVB2 xref: UniProtKB:Q8TBI9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0003999 ! PPP2R5A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006348 ! ppp2r5a-sgol2-2 physical interaction relationship: participates_in CCO:I0006353 ! sgol1-pp2r1b-ppp2r5a physical interaction relationship: participates_in CCO:I0006558 ! ppp2r5a-sgol1-1 physical interaction relationship: participates_in CCO:I0006760 ! sgol1-ppp2r5a-1 physical interaction relationship: participates_in CCO:I0007297 ! sgol1-ppp2r5a-2 colocalization [Term] id: CCO:B0005517 name: 2AAB_HUMAN def: "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform" [UniProtKB:P30154] synonym: "PP2A, subunit A, PR65-beta isoform" EXACT [UniProtKB:P30154] synonym: "PP2A, subunit A, R1-beta isoform" EXACT [UniProtKB:P30154] xref: EMBL:AAA59983.1 xref: EMBL:AAC63525.1 xref: EMBL:AAC69624.1 xref: EMBL:AAG39644.1 xref: UniProtKB:O75620 xref: UniProtKB:P30154 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004003 ! PPP2R1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006353 ! sgol1-pp2r1b-ppp2r5a physical interaction [Term] id: CCO:B0005518 name: 2A5E_HUMAN def: "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform" [UniProtKB:Q16537] synonym: "PP2A, B subunit, B' epsilon isoform" EXACT [UniProtKB:Q16537] synonym: "PP2A, B subunit, B56 epsilon isoform" EXACT [UniProtKB:Q16537] synonym: "PP2A, B subunit, PR61 epsilon isoform" EXACT [UniProtKB:Q16537] synonym: "PP2A, B subunit, R5 epsilon isoform" EXACT [UniProtKB:Q16537] xref: EMBL:AAB69752.1 xref: EMBL:AAH93766.1 xref: EMBL:CAA93153.1 xref: UniProtKB:Q16537 xref: UniProtKB:Q52LW4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004001 ! PPP2R5E_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006353 ! sgol1-pp2r1b-ppp2r5a physical interaction [Term] id: CCO:B0005519 name: SET_HUMAN def: "Protein SET" [UniProtKB:Q01105] synonym: "HLA-DR-associated protein II" EXACT [UniProtKB:Q01105] synonym: "I-2PP2A" EXACT [UniProtKB:Q01105] synonym: "IGAAD" EXACT [UniProtKB:Q01105] synonym: "Inhibitor of granzyme A-activated DNase" EXACT [UniProtKB:Q01105] synonym: "PHAPII" EXACT [UniProtKB:Q01105] synonym: "Phosphatase 2A inhibitor I2PP2A" EXACT [UniProtKB:Q01105] synonym: "TAF-I" EXACT [UniProtKB:Q01105] synonym: "Template-activating factor I" EXACT [UniProtKB:Q01105] xref: EMBL:AAA60318.1 xref: EMBL:AAC50460.1 xref: EMBL:AAH32749.1 xref: EMBL:AAQ79833.1 xref: EMBL:ABP96841.1 xref: EMBL:BAA08139.1 xref: EMBL:BAD97276.1 xref: EMBL:CAA52982.1 xref: EMBL:CAG38780.1 xref: EMBL:CAG46847.1 xref: EMBL:CAH71410.1 xref: UniProtKB:A5A5H4 xref: UniProtKB:Q01105 xref: UniProtKB:Q15541 xref: UniProtKB:Q5VXV1 xref: UniProtKB:Q6FHZ5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005598 ! SET_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006353 ! sgol1-pp2r1b-ppp2r5a physical interaction relationship: transforms_into CCO:B0014024 ! SET_HUMAN-Phosphoserine7 relationship: transforms_into CCO:B0014025 ! SET_HUMAN-Phosphoserine30 relationship: transforms_into CCO:B0031374 ! SET_HUMAN-Phosphotyrosine146 [Term] id: CCO:B0005520 name: M3K8_HUMAN def: "Mitogen-activated protein kinase kinase kinase 8" [UniProtKB:P41279] synonym: "C-COT" EXACT [UniProtKB:P41279] synonym: "Cancer Osaka thyroid oncogene" EXACT [UniProtKB:P41279] synonym: "COT proto-oncogene serine/threonine-protein kinase" EXACT [UniProtKB:P41279] synonym: "EC 2.7.11.25" EXACT [UniProtKB:P41279] synonym: "TPL-2" EXACT [UniProtKB:P41279] synonym: "Tumor progression locus 2" EXACT [UniProtKB:P41279] xref: EMBL:AAG13454.1 xref: EMBL:AAI04834.1 xref: EMBL:AAI13567.1 xref: EMBL:AAP45053.1 xref: EMBL:BAA03387.1 xref: EMBL:CAA78512.1 xref: EMBL:CAI14227.1 xref: UniProtKB:P41279 xref: UniProtKB:Q14275 xref: UniProtKB:Q5T855 xref: UniProtKB:Q9HC81 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005010 ! MAP3K8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006354 ! map3k8-ruvbl1 physical interaction [Term] id: CCO:B0005521 name: IKBA_HUMAN def: "NF-kappa-B inhibitor alpha" [UniProtKB:P25963] synonym: "I-kappa-B-alpha" EXACT [UniProtKB:P25963] synonym: "IkappaBalpha" EXACT [UniProtKB:P25963] synonym: "IkB-alpha" EXACT [UniProtKB:P25963] synonym: "Major histocompatibility complex enhancer-binding protein MAD3" EXACT [UniProtKB:P25963] xref: EMBL:AAA16489.1 xref: EMBL:AAH02601.1 xref: EMBL:AAH04983.1 xref: EMBL:AAK51149.1 xref: EMBL:AAP35754.1 xref: EMBL:AAR29599.1 xref: EMBL:CAB65556.2 xref: UniProtKB:P25963 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004871 ! NFKBIA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006355 ! nfkbia-mcm3 physical interaction relationship: participates_in CCO:I0006424 ! nfkbia-mcm7 physical interaction relationship: transforms_into CCO:B0012340 ! IKBA_HUMAN-Phosphoserine32 relationship: transforms_into CCO:B0012341 ! IKBA_HUMAN-Phosphoserine36 relationship: transforms_into CCO:B0012342 ! IKBA_HUMAN-Phosphotyrosine42 relationship: transforms_into CCO:B0041145 ! IKBA_HUMAN-Phosphoserine283 relationship: transforms_into CCO:B0041146 ! IKBA_HUMAN-Phosphoserine288 relationship: transforms_into CCO:B0041147 ! IKBA_HUMAN-Phosphothreonine291 relationship: transforms_into CCO:B0041148 ! IKBA_HUMAN-Phosphoserine293 relationship: transforms_into CCO:B0041149 ! IKBA_HUMAN-Phosphothreonine299 [Term] id: CCO:B0005522 name: IKKB_HUMAN def: "Inhibitor of nuclear factor kappa-B kinase subunit beta" [UniProtKB:O14920] synonym: "EC 2.7.11.10" EXACT [UniProtKB:O14920] synonym: "I-kappa-B kinase 2" EXACT [UniProtKB:O14920] synonym: "I-kappa-B-kinase beta" EXACT [UniProtKB:O14920] synonym: "IkBKB" EXACT [UniProtKB:O14920] synonym: "IKK-B" EXACT [UniProtKB:O14920] synonym: "IKK-beta" EXACT [UniProtKB:O14920] synonym: "IKK2" EXACT [UniProtKB:O14920] synonym: "NFKBIKB" EXACT [UniProtKB:O14920] synonym: "Nuclear factor NF-kappa-B inhibitor kinase beta" EXACT [UniProtKB:O14920] xref: EMBL:AAC51860.1 xref: EMBL:AAC64675.1 xref: EMBL:AAD08997.1 xref: EMBL:AAH06231.1 xref: EMBL:AAT65965.1 xref: UniProtKB:O14920 xref: UniProtKB:O75327 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004875 ! IKBKB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006431 ! ikbkb-cdc37 physical interaction relationship: participates_in CCO:I0008543 ! ikbkb-myh10 physical interaction relationship: transforms_into CCO:B0012349 ! IKKB_HUMAN-Phosphothreonine23 relationship: transforms_into CCO:B0012350 ! IKKB_HUMAN-Phosphoserine177 relationship: transforms_into CCO:B0012351 ! IKKB_HUMAN-Phosphoserine181 relationship: transforms_into CCO:B0012352 ! IKKB_HUMAN-Phosphoserine670 relationship: transforms_into CCO:B0012353 ! IKKB_HUMAN-Phosphoserine672 relationship: transforms_into CCO:B0012354 ! IKKB_HUMAN-Phosphoserine675 relationship: transforms_into CCO:B0012355 ! IKKB_HUMAN-Phosphoserine682 relationship: transforms_into CCO:B0012356 ! IKKB_HUMAN-Phosphoserine689 relationship: transforms_into CCO:B0012357 ! IKKB_HUMAN-Phosphoserine692 relationship: transforms_into CCO:B0012358 ! IKKB_HUMAN-Phosphoserine695 relationship: transforms_into CCO:B0012359 ! IKKB_HUMAN-Phosphoserine697 relationship: transforms_into CCO:B0012360 ! IKKB_HUMAN-Phosphoserine705 relationship: transforms_into CCO:B0012361 ! IKKB_HUMAN-Phosphoserine733 relationship: transforms_into CCO:B0012362 ! IKKB_HUMAN-Phosphoserine740 relationship: transforms_into CCO:B0012363 ! IKKB_HUMAN-Phosphoserine750 relationship: transforms_into CCO:B0041152 ! IKKB_HUMAN-S-nitrosocysteine179 [Term] id: CCO:B0005523 name: IKKE_HUMAN def: "Inhibitor of nuclear factor kappa-B kinase subunit epsilon" [UniProtKB:Q14164] synonym: "EC 2.7.11.10" EXACT [UniProtKB:Q14164] synonym: "I kappa-B kinase epsilon" EXACT [UniProtKB:Q14164] synonym: "IkBKE" EXACT [UniProtKB:Q14164] synonym: "IKK-E" EXACT [UniProtKB:Q14164] synonym: "IKK-epsilon" EXACT [UniProtKB:Q14164] synonym: "IKK-i" EXACT [UniProtKB:Q14164] synonym: "Inducible I kappa-B kinase" EXACT [UniProtKB:Q14164] xref: EMBL:AAF45307.1 xref: EMBL:AAI05924.1 xref: EMBL:AAI05925.1 xref: EMBL:ABG25921.1 xref: EMBL:BAA09772.2 xref: EMBL:BAA85155.1 xref: EMBL:CAI15250.1 xref: UniProtKB:Q14164 xref: UniProtKB:Q3KR43 xref: UniProtKB:Q5JTS6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004876 ! IKBKE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006358 ! ikbke-kif11 physical interaction relationship: participates_in CCO:I0006359 ! ikbke-ruvbl1 physical interaction relationship: participates_in CCO:I0006432 ! ikbke-cdc37 physical interaction relationship: participates_in CCO:I0008544 ! ikbke-myh10 physical interaction relationship: transforms_into CCO:B0012364 ! IKKE_HUMAN-Phosphoserine172 [Term] id: CCO:B0005524 name: NEMO_HUMAN def: "NF-kappa-B essential modulator" [UniProtKB:Q9Y6K9] synonym: "FIP-3" EXACT [UniProtKB:Q9Y6K9] synonym: "I-kappa-B kinase gamma" EXACT [UniProtKB:Q9Y6K9] synonym: "IkB kinase subunit gamma" EXACT [UniProtKB:Q9Y6K9] synonym: "IkB kinase-associated protein 1" EXACT [UniProtKB:Q9Y6K9] synonym: "IKK-gamma" EXACT [UniProtKB:Q9Y6K9] synonym: "IKKAP1" EXACT [UniProtKB:Q9Y6K9] synonym: "IKKG" EXACT [UniProtKB:Q9Y6K9] synonym: "Inhibitor of nuclear factor kappa-B kinase subunit gamma" EXACT [UniProtKB:Q9Y6K9] synonym: "NEMO" EXACT [UniProtKB:Q9Y6K9] synonym: "NF-kappa-B essential modifier" EXACT [UniProtKB:Q9Y6K9] xref: EMBL:AAC36330.1 xref: EMBL:AAD12183.1 xref: EMBL:AAD38081.1 xref: EMBL:AAF99679.1 xref: EMBL:AAH00299.1 xref: EMBL:AAH12114.1 xref: EMBL:AAH50612.1 xref: EMBL:AAV38427.1 xref: EMBL:CAB93146.1 xref: UniProtKB:Q9Y6K9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005183 ! IKBKG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006360 ! ikbkg-smc2l1 physical interaction relationship: participates_in CCO:I0006361 ! ikbkg-msh2 physical interaction relationship: participates_in CCO:I0006362 ! ikbkg-mcm7 physical interaction relationship: participates_in CCO:I0006363 ! ikbkg-dnch1 physical interaction relationship: participates_in CCO:I0006364 ! ikbkg-smc4l1 physical interaction relationship: participates_in CCO:I0006365 ! ikbkg-q8ix12 physical interaction relationship: participates_in CCO:I0006366 ! ikbkg-ppp1cc physical interaction relationship: participates_in CCO:I0006367 ! ikbkg-ppp1cb physical interaction relationship: participates_in CCO:I0006433 ! ikbkg-cdc37 physical interaction relationship: participates_in CCO:I0008518 ! ikbkg-ddb1 physical interaction relationship: participates_in CCO:I0008545 ! ikbkg-myh10 physical interaction relationship: transforms_into CCO:B0041163 ! NEMO_HUMAN-Phosphoserine31 relationship: transforms_into CCO:B0041164 ! NEMO_HUMAN-Phosphoserine43 relationship: transforms_into CCO:B0041165 ! NEMO_HUMAN-Phosphoserine68 relationship: transforms_into CCO:B0041166 ! NEMO_HUMAN-Phosphoserine85 relationship: transforms_into CCO:B0041167 ! NEMO_HUMAN-Phosphoserine376 [Term] id: CCO:B0005525 name: M3K1_HUMAN def: "Mitogen-activated protein kinase kinase kinase 1" [UniProtKB:Q13233] synonym: "EC 2.7.11.25" EXACT [UniProtKB:Q13233] synonym: "MAPK/ERK kinase kinase 1" EXACT [UniProtKB:Q13233] synonym: "MEK kinase 1" EXACT [UniProtKB:Q13233] synonym: "MEKK 1" EXACT [UniProtKB:Q13233] xref: EMBL:AAB05828.1 xref: EMBL:AAC97073.1 xref: UniProtKB:Q13233 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005006 ! MAP3K1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006434 ! map3k1-cdc37 physical interaction relationship: participates_in CCO:I0008519 ! map3k1-ddb1 physical interaction relationship: participates_in CCO:I0008546 ! map3k1-myh10 physical interaction relationship: transforms_into CCO:B0012731 ! M3K1_HUMAN-Phosphothreonine1402 relationship: transforms_into CCO:B0012732 ! M3K1_HUMAN-Phosphothreonine1414 relationship: transforms_into CCO:B0036011 ! M3K1_HUMAN-Phosphothreonine657 relationship: transforms_into CCO:B0036012 ! M3K1_HUMAN-Phosphothreonine665 [Term] id: CCO:B0005526 name: M3K3_HUMAN def: "Mitogen-activated protein kinase kinase kinase 3" [UniProtKB:Q99759] synonym: "EC 2.7.11.25" EXACT [UniProtKB:Q99759] synonym: "MAPK/ERK kinase kinase 3" EXACT [UniProtKB:Q99759] synonym: "MEK kinase 3" EXACT [UniProtKB:Q99759] synonym: "MEKK 3" EXACT [UniProtKB:Q99759] xref: EMBL:AAB41729.1 xref: EMBL:AAH90859.1 xref: EMBL:AAH93672.1 xref: EMBL:AAH93674.1 xref: EMBL:EAW94298.1 xref: UniProtKB:Q5BKZ6 xref: UniProtKB:Q99759 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005007 ! MAP3K3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006372 ! map3k3-pfdn1 physical interaction relationship: participates_in CCO:I0006373 ! map3k3-hspa2 physical interaction relationship: participates_in CCO:I0006374 ! map3k3-sugt1 physical interaction relationship: participates_in CCO:I0006375 ! map3k3-mcc physical interaction relationship: participates_in CCO:I0006378 ! map3k3-ruvbl1 physical interaction relationship: participates_in CCO:I0006379 ! map3k3-ppp1ca physical interaction relationship: participates_in CCO:I0006381 ! map3k3-nudc physical interaction relationship: participates_in CCO:I0006385 ! map3k3-ppp1cc physical interaction relationship: participates_in CCO:I0006386 ! map3k3-dlg1 physical interaction relationship: participates_in CCO:I0006436 ! map3k3-cdc37 physical interaction relationship: participates_in CCO:I0008520 ! map3k3-ddb1 physical interaction relationship: participates_in CCO:I0008547 ! map3k3-myh10 physical interaction relationship: transforms_into CCO:B0012733 ! M3K3_HUMAN-Phosphotyrosine288 relationship: transforms_into CCO:B0012734 ! M3K3_HUMAN-Phosphoserine289 relationship: transforms_into CCO:B0012735 ! M3K3_HUMAN-Phosphothreonine294 relationship: transforms_into CCO:B0012736 ! M3K3_HUMAN-Phosphoserine337 relationship: transforms_into CCO:B0012737 ! M3K3_HUMAN-Phosphoserine340 relationship: transforms_into CCO:B0012738 ! M3K3_HUMAN-Phosphothreonine530 [Term] id: CCO:B0005528 name: M3K14_HUMAN def: "Mitogen-activated protein kinase kinase kinase 14" [UniProtKB:Q99558] synonym: "EC 2.7.11.25" EXACT [UniProtKB:Q99558] synonym: "HsNIK" EXACT [UniProtKB:Q99558] synonym: "NF-kappa beta-inducing kinase" EXACT [UniProtKB:Q99558] synonym: "Serine/threonine-protein kinase NIK" EXACT [UniProtKB:Q99558] xref: EMBL:AAH35576.1 xref: EMBL:ABC40733.1 xref: EMBL:CAA71306.1 xref: UniProtKB:Q8IYN1 xref: UniProtKB:Q99558 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005005 ! MAP3K14_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006389 ! map3k14-ruvbl1 physical interaction relationship: participates_in CCO:I0006392 ! map3k14-rara physical interaction relationship: participates_in CCO:I0006427 ! map3k14-cdc37 physical interaction [Term] id: CCO:B0005529 name: RELB_HUMAN def: "Transcription factor RelB" [UniProtKB:Q01201] synonym: "I-Rel" EXACT [UniProtKB:Q01201] xref: EMBL:AAA36127.1 xref: EMBL:AAC82346.1 xref: EMBL:AAH28013.1 xref: EMBL:ABC40746.1 xref: UniProtKB:Q01201 xref: UniProtKB:Q6GTX7 xref: UniProtKB:Q9UEI7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005464 ! RELB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006393 ! relb-ruvbl1 physical interaction relationship: participates_in CCO:I0006437 ! relb-hdac6 physical interaction relationship: participates_in CCO:I0006438 ! relb-kpna2 physical interaction relationship: transforms_into CCO:B0041178 ! RELB_HUMAN-Phosphothreonine103 relationship: transforms_into CCO:B0041179 ! RELB_HUMAN-Phosphoserine573 [Term] id: CCO:B0005530 name: Q6P5Y1_HUMAN def: "Receptor-interacting serine-threonine kinase 3" [UniProtKB:Q6P5Y1] synonym: "Receptor interacting protein 3" EXACT [UniProtKB:Q6P5Y1] synonym: "Receptor-interacting serine-threonine kinase 3, isoform CRA_a" EXACT [UniProtKB:Q6P5Y1] xref: EMBL:AAH62584.1 xref: EMBL:AAS16359.1 xref: EMBL:EAW66021.1 xref: UniProtKB:Q6P5Y1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006013 ! RIPK3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006396 ! aah62584-cdc37 physical interaction relationship: participates_in CCO:I0006399 ! aah62584-ruvbl1 physical interaction relationship: participates_in CCO:I0006401 ! aah62584-q96sb3 physical interaction relationship: participates_in CCO:I0006403 ! aah62584-ppp1cc physical interaction relationship: participates_in CCO:I0006404 ! aah62584-ppp1cb physical interaction relationship: participates_in CCO:I0008549 ! aah62584-myh10 physical interaction [Term] id: CCO:B0005531 name: TAB1_HUMAN def: "Mitogen-activated protein kinase kinase kinase 7-interacting protein 1" [UniProtKB:Q15750] synonym: "TAK1-binding protein 1" EXACT [UniProtKB:Q15750] synonym: "TGF-beta-activated kinase 1-binding protein 1" EXACT [UniProtKB:Q15750] xref: EMBL:AAC12660.1 xref: EMBL:AAH50554.1 xref: EMBL:ABC40735.1 xref: EMBL:CAB55304.1 xref: UniProtKB:Q15750 xref: UniProtKB:Q2PP09 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005719 ! MAP3K7IP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006405 ! map3k7ip1-ruvbl1 physical interaction [Term] id: CCO:B0005532 name: TAB2_HUMAN def: "Mitogen-activated protein kinase kinase kinase 7-interacting protein 2" [UniProtKB:Q9NYJ8] synonym: "TAK1-binding protein 2" EXACT [UniProtKB:Q9NYJ8] xref: EMBL:AAF67176.1 xref: EMBL:AAH35910.1 xref: EMBL:ABC40736.1 xref: EMBL:BAA34453.2 xref: EMBL:CAB55907.1 xref: EMBL:CAG33668.1 xref: EMBL:CAI19581.1 xref: EMBL:CAI20026.1 xref: EMBL:CAI20971.1 xref: UniProtKB:O94838 xref: UniProtKB:Q6I9W8 xref: UniProtKB:Q76N06 xref: UniProtKB:Q9NYJ8 xref: UniProtKB:Q9UFP7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005720 ! MAP3K7IP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006407 ! q9nyj8-hspa2 physical interaction relationship: participates_in CCO:I0006408 ! q9nyj8-ruvbl1 physical interaction relationship: transforms_into CCO:B0014292 ! TAB2_HUMAN-Phosphoserine450 [Term] id: CCO:B0005533 name: TBK1_HUMAN def: "Serine/threonine-protein kinase TBK1" [UniProtKB:Q9UHD2] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9UHD2] synonym: "NF-kappa-B-activating kinase" EXACT [UniProtKB:Q9UHD2] synonym: "T2K" EXACT [UniProtKB:Q9UHD2] synonym: "TANK-binding kinase 1" EXACT [UniProtKB:Q9UHD2] xref: EMBL:AAF05989.1 xref: EMBL:AAF69106.1 xref: EMBL:AAH34950.1 xref: EMBL:BAA92129.1 xref: UniProtKB:Q8IYV3 xref: UniProtKB:Q9NUJ5 xref: UniProtKB:Q9UHD2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005741 ! TBK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006410 ! tbk1-ruvbl1 physical interaction relationship: participates_in CCO:I0006439 ! tbk1-cdc37 physical interaction relationship: transforms_into CCO:B0014318 ! TBK1_HUMAN-Phosphoserine172 [Term] id: CCO:B0005534 name: TNR1A_HUMAN def: "Tumor necrosis factor receptor superfamily member 1A precursor" [UniProtKB:P19438] synonym: "CD120a antigen" EXACT [UniProtKB:P19438] synonym: "p55" EXACT [UniProtKB:P19438] synonym: "p60" EXACT [UniProtKB:P19438] synonym: "TNF-R1" EXACT [UniProtKB:P19438] synonym: "TNF-RI" EXACT [UniProtKB:P19438] synonym: "TNFR-I" EXACT [UniProtKB:P19438] xref: EMBL:AAA03210.1 xref: EMBL:AAA36753.1 xref: EMBL:AAA36754.1 xref: EMBL:AAA36756.1 xref: EMBL:AAA61201.1 xref: EMBL:AAH10140.1 xref: EMBL:AAM77802.1 xref: EMBL:CAA01558.1 xref: EMBL:CAA39021.1 xref: UniProtKB:P19438 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005803 ! TNFRSF1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006413 ! tnfrsf1a-ruvbl1 physical interaction relationship: participates_in CCO:I0006440 ! tnfrsf1a-fancd2 physical interaction relationship: participates_in CCO:I0008550 ! tnfrsf1a-myh10 physical interaction [Term] id: CCO:B0005535 name: TNR1B_HUMAN def: "Tumor necrosis factor receptor superfamily member 1B precursor" [UniProtKB:P20333] synonym: "CD120b antigen" EXACT [UniProtKB:P20333] synonym: "Etanercept" EXACT [UniProtKB:P20333] synonym: "p75" EXACT [UniProtKB:P20333] synonym: "p80 TNF-alpha receptor" EXACT [UniProtKB:P20333] synonym: "TNF-R2" EXACT [UniProtKB:P20333] synonym: "Tumor necrosis factor receptor 2" EXACT [UniProtKB:P20333] synonym: "Tumor necrosis factor receptor type II" EXACT [UniProtKB:P20333] xref: EMBL:AAA36755.1 xref: EMBL:AAA59929.1 xref: EMBL:AAA63262.1 xref: EMBL:AAB19824.2 xref: EMBL:AAC50622.1 xref: EMBL:AAH52977.1 xref: EMBL:AAN72434.1 xref: EMBL:AAO89076.1 xref: EMBL:AAP88939.1 xref: EMBL:AAV38730.1 xref: EMBL:BAA89053.1 xref: EMBL:CAH73721.1 xref: UniProtKB:P20333 xref: UniProtKB:Q16042 xref: UniProtKB:Q6YI29 xref: UniProtKB:Q9UIH1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005804 ! TNFRSF1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006415 ! tnfrsf1b-mad2l1 physical interaction relationship: participates_in CCO:I0006442 ! tnfrsf1b-fancd2 physical interaction relationship: participates_in CCO:I0008521 ! tnfrsf1b-ddb1 physical interaction relationship: participates_in CCO:I0008551 ! tnfrsf1b-myh10 physical interaction [Term] id: CCO:B0005536 name: TRAF6_HUMAN def: "TNF receptor-associated factor 6" [UniProtKB:Q9Y4K3] synonym: "Interleukin-1 signal transducer" EXACT [UniProtKB:Q9Y4K3] synonym: "RING finger protein 85" EXACT [UniProtKB:Q9Y4K3] xref: EMBL:AAB38751.1 xref: EMBL:AAH31052.1 xref: EMBL:AAO38054.1 xref: UniProtKB:Q8NEH5 xref: UniProtKB:Q9Y4K3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005824 ! TRAF6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006419 ! traf6-psmd8 physical interaction relationship: participates_in CCO:I0006420 ! traf6-psmd2 physical interaction relationship: participates_in CCO:I0006422 ! traf6-fancd2 physical interaction relationship: participates_in CCO:I0006428 ! traf6-psmd1 physical interaction relationship: participates_in CCO:I0008705 ! traf6-psmb6 physical interaction relationship: participates_in CCO:I0008706 ! traf6-psma4 physical interaction relationship: participates_in CCO:I0008707 ! traf6-psmc6 physical interaction relationship: participates_in CCO:I0008708 ! traf6-psmd4 physical interaction relationship: participates_in CCO:I0008709 ! traf6-psmc5 physical interaction relationship: participates_in CCO:I0008710 ! traf6-psmb2 physical interaction relationship: participates_in CCO:I0008711 ! traf6-psma1 physical interaction relationship: participates_in CCO:I0008712 ! traf6-psmd6 physical interaction relationship: participates_in CCO:I0008713 ! traf6-psmb5 physical interaction relationship: participates_in CCO:I0008714 ! traf6-psmc1 physical interaction relationship: participates_in CCO:I0008715 ! traf6-psmc2 physical interaction relationship: participates_in CCO:I0008716 ! traf6-psmc3 physical interaction relationship: participates_in CCO:I0008717 ! traf6-psmd12 physical interaction relationship: participates_in CCO:I0008718 ! traf6-psmd3 physical interaction relationship: participates_in CCO:I0008719 ! traf6-psmd7 physical interaction [Term] id: CCO:B0005537 name: IKBB_HUMAN def: "NF-kappa-B inhibitor beta" [UniProtKB:Q15653] synonym: "I-kappa-B-beta" EXACT [UniProtKB:Q15653] synonym: "IkappaBbeta" EXACT [UniProtKB:Q15653] synonym: "IkB-B" EXACT [UniProtKB:Q15653] synonym: "IkB-beta" EXACT [UniProtKB:Q15653] synonym: "NF-kappa-BIB" EXACT [UniProtKB:Q15653] synonym: "Thyroid receptor-interacting protein 9" EXACT [UniProtKB:Q15653] synonym: "TR-interacting protein 9" EXACT [UniProtKB:Q15653] synonym: "TRIP-9" EXACT [UniProtKB:Q15653] xref: EMBL:AAC41742.1 xref: EMBL:AAH07197.1 xref: EMBL:AAH15528.1 xref: EMBL:AAP35389.1 xref: EMBL:AAU10088.1 xref: UniProtKB:Q15653 xref: UniProtKB:Q96BJ7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004872 ! NFKBIB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006425 ! nfkbib-kpna2 physical interaction relationship: participates_in CCO:I0006426 ! nfkbib-mcc physical interaction relationship: participates_in CCO:I0007400 ! mcc-nfkbib physical interaction relationship: transforms_into CCO:B0012343 ! IKBB_HUMAN-Phosphoserine19 relationship: transforms_into CCO:B0012344 ! IKBB_HUMAN-Phosphoserine23 relationship: transforms_into CCO:B0041150 ! IKBB_HUMAN-Phosphoserine313 relationship: transforms_into CCO:B0041151 ! IKBB_HUMAN-Phosphoserine315 [Term] id: CCO:B0005538 name: IKBE_HUMAN def: "NF-kappa-B inhibitor epsilon" [UniProtKB:O00221] synonym: "I-kappa-B-epsilon" EXACT [UniProtKB:O00221] synonym: "IkappaBepsilon" EXACT [UniProtKB:O00221] synonym: "IkB-E" EXACT [UniProtKB:O00221] synonym: "IkB-epsilon" EXACT [UniProtKB:O00221] synonym: "NF-kappa-BIE" EXACT [UniProtKB:O00221] xref: EMBL:AAC51216.1 xref: UniProtKB:O00221 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004873 ! NFKBIE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006429 ! nfkbie-ppp6c physical interaction relationship: participates_in CCO:I0008703 ! nfkbie-psma5 physical interaction relationship: participates_in CCO:I0008704 ! nfkbie-psme3 physical interaction relationship: transforms_into CCO:B0012345 ! IKBE_HUMAN-Phosphoserine18 relationship: transforms_into CCO:B0012346 ! IKBE_HUMAN-Phosphoserine22 [Term] id: CCO:B0005539 name: IKKA_HUMAN def: "Inhibitor of nuclear factor kappa-B kinase subunit alpha" [UniProtKB:O15111] synonym: "Conserved helix-loop-helix ubiquitous kinase" EXACT [UniProtKB:O15111] synonym: "EC 2.7.11.10" EXACT [UniProtKB:O15111] synonym: "I kappa-B kinase alpha" EXACT [UniProtKB:O15111] synonym: "I-kappa-B kinase 1" EXACT [UniProtKB:O15111] synonym: "IkappaB kinase" EXACT [UniProtKB:O15111] synonym: "IkBKA" EXACT [UniProtKB:O15111] synonym: "IKK-A" EXACT [UniProtKB:O15111] synonym: "IKK-alpha" EXACT [UniProtKB:O15111] synonym: "IKK1" EXACT [UniProtKB:O15111] synonym: "NFKBIKA" EXACT [UniProtKB:O15111] synonym: "Nuclear factor NF-kappa-B inhibitor kinase alpha" EXACT [UniProtKB:O15111] xref: EMBL:AAC50713.1 xref: EMBL:AAC51662.1 xref: EMBL:AAC51671.1 xref: EMBL:AAD08996.1 xref: EMBL:AAT49098.1 xref: EMBL:CAH72401.1 xref: UniProtKB:O14666 xref: UniProtKB:O15111 xref: UniProtKB:Q13132 xref: UniProtKB:Q5W0I4 xref: UniProtKB:Q92467 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004874 ! CHUK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006430 ! chuk-cdc37 physical interaction relationship: participates_in CCO:I0008542 ! chuk-myh10 physical interaction relationship: transforms_into CCO:B0012347 ! IKKA_HUMAN-Phosphothreonine23 relationship: transforms_into CCO:B0012348 ! IKKA_HUMAN-Phosphoserine176 [Term] id: CCO:B0005540 name: ERBB2_HUMAN def: "Receptor tyrosine-protein kinase erbB-2 precursor" [UniProtKB:P04626] synonym: "C-erbB-2" EXACT [UniProtKB:P04626] synonym: "CD340 antigen" EXACT [UniProtKB:P04626] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P04626] synonym: "MLN 19" EXACT [UniProtKB:P04626] synonym: "NEU proto-oncogene" EXACT [UniProtKB:P04626] synonym: "p185erbB2" EXACT [UniProtKB:P04626] synonym: "Tyrosine kinase-type cell surface receptor HER2" EXACT [UniProtKB:P04626] xref: EMBL:AAA35808.1 xref: EMBL:AAA35809.1 xref: EMBL:AAA35978.1 xref: EMBL:AAA58637.1 xref: EMBL:AAA75493.1 xref: EMBL:AAC37531.1 xref: EMBL:AAO18082.1 xref: EMBL:CAA27060.1 xref: UniProtKB:P04626 xref: UniProtKB:Q14256 xref: UniProtKB:Q6LDV1 xref: UniProtKB:Q9UMK4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004577 ! ERBB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006444 ! erbb2-egfr physical interaction relationship: participates_in CCO:I0006445 ! erbb2-egfr-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007304 ! erbb2-egfr-2 physical interaction relationship: participates_in CCO:I0007305 ! erbb2-egfr-3 physical interaction relationship: participates_in CCO:I0007591 ! erbb1-erbb2-1 physical interaction relationship: participates_in CCO:I0007817 ! erbb2-egfr-4 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0011738 ! ERBB2_HUMAN-Phosphotyrosine1139 relationship: transforms_into CCO:B0011739 ! ERBB2_HUMAN-Phosphotyrosine1196 relationship: transforms_into CCO:B0011740 ! ERBB2_HUMAN-Phosphotyrosine1248 [Term] id: CCO:B0005541 name: UCHL1_HUMAN def: "Ubiquitin carboxyl-terminal hydrolase isozyme L1" [UniProtKB:P09936] synonym: "EC 3.4.19.12" EXACT [UniProtKB:P09936] synonym: "EC 6.-.-.-" EXACT [UniProtKB:P09936] synonym: "Neuron cytoplasmic protein 9.5" EXACT [UniProtKB:P09936] synonym: "PGP 9.5" EXACT [UniProtKB:P09936] synonym: "PGP9.5" EXACT [UniProtKB:P09936] synonym: "Ubiquitin thioesterase L1" EXACT [UniProtKB:P09936] synonym: "UCH-L1" EXACT [UniProtKB:P09936] xref: EMBL:AAD09172.1 xref: EMBL:AAH00332.1 xref: EMBL:AAH05117.1 xref: EMBL:AAH06305.1 xref: EMBL:CAA28443.1 xref: EMBL:CAA35249.1 xref: UniProtKB:P09936 xref: UniProtKB:Q71UM0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005875 ! UCHL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006462 ! cdkn1b-uchl1 physical interaction relationship: participates_in CCO:I0006789 ! uchl1-ube2i physical interaction relationship: participates_in CCO:I0007045 ! cdn1b-uchl1 colocalization [Term] id: CCO:B0005544 name: Q9Y4F8_HUMAN def: "KIAA0387 protein" [UniProtKB:Q9Y4F8] xref: EMBL:BAA20841.2 xref: UniProtKB:Q9Y4F8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006057 ! KIAA0387_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006471 ! kiaa0387-kiaa0097 physical interaction [Term] id: CCO:B0005545 name: NRX1A_HUMAN def: "Neurexin-1-alpha precursor" [UniProtKB:Q9ULB1] synonym: "Neurexin I-alpha" EXACT [UniProtKB:Q9ULB1] xref: EMBL:AAF03536.1 xref: EMBL:AAG38120.1 xref: EMBL:AAG59602.1 xref: EMBL:AAG59642.1 xref: EMBL:AAK06387.1 xref: EMBL:AAY14894.1 xref: EMBL:AAY14944.1 xref: EMBL:BAA25504.2 xref: EMBL:BAA87821.1 xref: UniProtKB:O60323 xref: UniProtKB:Q53TJ9 xref: UniProtKB:Q53TQ1 xref: UniProtKB:Q9C079 xref: UniProtKB:Q9C080 xref: UniProtKB:Q9C081 xref: UniProtKB:Q9H3M2 xref: UniProtKB:Q9UDM6 xref: UniProtKB:Q9ULB1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005215 ! NRXN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006472 ! kiaa0578-kiaa0865 physical interaction [Term] id: CCO:B0005546 name: CELR3_HUMAN def: "Cadherin EGF LAG seven-pass G-type receptor 3 precursor" [UniProtKB:Q9NYQ7] synonym: "Epidermal growth factor-like 1" EXACT [UniProtKB:Q9NYQ7] synonym: "Flamingo homolog 1" EXACT [UniProtKB:Q9NYQ7] synonym: "hFmi1" EXACT [UniProtKB:Q9NYQ7] synonym: "Multiple epidermal growth factor-like domains 2" EXACT [UniProtKB:Q9NYQ7] xref: EMBL:AAF61929.1 xref: EMBL:BAA32464.1 xref: UniProtKB:O75092 xref: UniProtKB:Q9NYQ7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004320 ! CELSR3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006473 ! celsr3-bpag1 physical interaction relationship: transforms_into CCO:B0011132 ! CELR3_HUMAN-3-hydroxyaspartate1963 [Term] id: CCO:B0005547 name: PLXB3_HUMAN def: "Plexin-B3 precursor" [UniProtKB:Q9ULL4] xref: EMBL:AAG01376.1 xref: EMBL:BAA86520.1 xref: UniProtKB:Q9HDA4 xref: UniProtKB:Q9ULL4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005342 ! PLXNB3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006475 ! kiaa1206-parc physical interaction [Term] id: CCO:B0005548 name: Q9HCM3_HUMAN def: "KIAA1549 protein" [UniProtKB:Q9HCM3] xref: EMBL:BAB13375.2 xref: UniProtKB:Q9HCM3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006049 ! KIAA1549_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006476 ! kiaa1549-bpag1 physical interaction [Term] id: CCO:B0005551 name: ARNT_HUMAN def: "Aryl hydrocarbon receptor nuclear translocator" [UniProtKB:P27540] synonym: "ARNT protein" EXACT [UniProtKB:P27540] synonym: "Dioxin receptor, nuclear translocator" EXACT [UniProtKB:P27540] synonym: "HIF-1 beta" EXACT [UniProtKB:P27540] synonym: "Hypoxia-inducible factor 1 beta" EXACT [UniProtKB:P27540] xref: EMBL:AAA51777.1 xref: EMBL:AAQ96598.1 xref: EMBL:CAC21446.1 xref: UniProtKB:P27540 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004099 ! ARNT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006479 ! ahr-arnt-3 physical interaction relationship: participates_in CCO:I0006480 ! ahr-arnt-4 physical interaction relationship: participates_in CCO:I0006545 ! ahr-arnt-1 physical interaction relationship: participates_in CCO:I0006547 ! ahr-arnt-2 physical interaction [Term] id: CCO:B0005552 name: NCOA7_HUMAN def: "Nuclear receptor coactivator 7" [UniProtKB:Q8NI08] synonym: "140 kDa estrogen receptor-associated protein" EXACT [UniProtKB:Q8NI08] synonym: "Estrogen nuclear receptor coactivator 1" EXACT [UniProtKB:Q8NI08] xref: EMBL:AAH36461.1 xref: EMBL:AAH71782.1 xref: EMBL:AAM27392.1 xref: EMBL:BAC04402.1 xref: EMBL:BAE45732.1 xref: EMBL:CAD89948.1 xref: EMBL:CAD97627.1 xref: EMBL:CAI20072.1 xref: EMBL:CAI42386.1 xref: EMBL:CAI42397.1 xref: UniProtKB:Q3LID6 xref: UniProtKB:Q4G0V1 xref: UniProtKB:Q5TF95 xref: UniProtKB:Q6IPQ4 xref: UniProtKB:Q6NE83 xref: UniProtKB:Q86T89 xref: UniProtKB:Q8N1W4 xref: UniProtKB:Q8NI08 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005161 ! NCOA7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006479 ! ahr-arnt-3 physical interaction relationship: participates_in CCO:I0006544 ! ahr-erap_140-1 physical interaction [Term] id: CCO:B0005553 name: NCOR2_HUMAN def: "Nuclear receptor corepressor 2" [UniProtKB:Q9Y618] synonym: "CTG repeat protein 26" EXACT [UniProtKB:Q9Y618] synonym: "N-CoR2" EXACT [UniProtKB:Q9Y618] synonym: "Silencing mediator of retinoic acid and thyroid hormone receptor" EXACT [UniProtKB:Q9Y618] synonym: "SMAP270" EXACT [UniProtKB:Q9Y618] synonym: "SMRT" EXACT [UniProtKB:Q9Y618] synonym: "SMRTe" EXACT [UniProtKB:Q9Y618] synonym: "T3 receptor-associating factor" EXACT [UniProtKB:Q9Y618] synonym: "Thyroid-, retinoic-acid-receptor-associated corepressor" EXACT [UniProtKB:Q9Y618] synonym: "TRAC" EXACT [UniProtKB:Q9Y618] xref: EMBL:AAB50847.1 xref: EMBL:AAB91446.1 xref: EMBL:AAC50236.1 xref: EMBL:AAD20946.1 xref: EMBL:AAD22973.1 xref: UniProtKB:O00613 xref: UniProtKB:O15416 xref: UniProtKB:Q13354 xref: UniProtKB:Q9Y5U0 xref: UniProtKB:Q9Y618 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005162 ! NCOR2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006480 ! ahr-arnt-4 physical interaction relationship: participates_in CCO:I0006546 ! ahr-ncor2-1 physical interaction relationship: participates_in CCO:I0007582 ! bcl6-hdac4 physical interaction relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0013110 ! NCOR2_HUMAN-Phosphoserine149 relationship: transforms_into CCO:B0013111 ! NCOR2_HUMAN-Phosphoserine152 relationship: transforms_into CCO:B0013112 ! NCOR2_HUMAN-Phosphoserine215 relationship: transforms_into CCO:B0013113 ! NCOR2_HUMAN-Phosphothreonine553 relationship: transforms_into CCO:B0013114 ! NCOR2_HUMAN-Phosphoserine554 relationship: transforms_into CCO:B0013115 ! NCOR2_HUMAN-Phosphoserine939 relationship: transforms_into CCO:B0013116 ! NCOR2_HUMAN-Phosphoserine1253 relationship: transforms_into CCO:B0013117 ! NCOR2_HUMAN-Phosphothreonine1383 relationship: transforms_into CCO:B0013118 ! NCOR2_HUMAN-Phosphoserine1576 relationship: transforms_into CCO:B0013119 ! NCOR2_HUMAN-Phosphoserine1974 relationship: transforms_into CCO:B0013120 ! NCOR2_HUMAN-Phosphoserine2008 relationship: transforms_into CCO:B0013121 ! NCOR2_HUMAN-Phosphoserine2049 relationship: transforms_into CCO:B0013122 ! NCOR2_HUMAN-Phosphoserine2057 relationship: transforms_into CCO:B0013123 ! NCOR2_HUMAN-Phosphoserine2061 relationship: transforms_into CCO:B0013124 ! NCOR2_HUMAN-Phosphoserine2197 relationship: transforms_into CCO:B0013125 ! NCOR2_HUMAN-Phosphoserine2200 relationship: transforms_into CCO:B0013126 ! NCOR2_HUMAN-Phosphoserine2261 relationship: transforms_into CCO:B0013127 ! NCOR2_HUMAN-Phosphoserine2455 relationship: transforms_into CCO:B0013128 ! NCOR2_HUMAN-Phosphoserine2514 relationship: transforms_into CCO:B0013129 ! NCOR2_HUMAN-Phosphoserine2516 relationship: transforms_into CCO:B0036018 ! NCOR2_HUMAN-Phosphoserine956 [Term] id: CCO:B0005554 name: EXOS4_HUMAN def: "Exosome complex exonuclease RRP41" [UniProtKB:Q9NPD3] synonym: "EC 3.1.13.-" EXACT [UniProtKB:Q9NPD3] synonym: "Exosome component 4" EXACT [UniProtKB:Q9NPD3] synonym: "p12A" EXACT [UniProtKB:Q9NPD3] synonym: "Ribosomal RNA-processing protein 41" EXACT [UniProtKB:Q9NPD3] xref: EMBL:AAF82134.1 xref: EMBL:AAH02777.1 xref: EMBL:BAA91279.1 xref: UniProtKB:Q9NPD3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004598 ! EXOSC4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006481 ! exosc4-nek1 physical interaction relationship: transforms_into CCO:B0011811 ! EXOS4_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005555 name: EXOS5_HUMAN def: "Exosome complex exonuclease RRP46" [UniProtKB:Q9NQT4] synonym: "Chronic myelogenous leukemia tumor antigen 28" EXACT [UniProtKB:Q9NQT4] synonym: "EC 3.1.13.-" EXACT [UniProtKB:Q9NQT4] synonym: "Exosome component 5" EXACT [UniProtKB:Q9NQT4] synonym: "p12B" EXACT [UniProtKB:Q9NQT4] synonym: "Ribosomal RNA-processing protein 46" EXACT [UniProtKB:Q9NQT4] xref: EMBL:AAF82135.1 xref: EMBL:AAH07742.1 xref: EMBL:AAI07697.1 xref: EMBL:AAM75154.1 xref: UniProtKB:Q32Q81 xref: UniProtKB:Q8NG16 xref: UniProtKB:Q96I89 xref: UniProtKB:Q9NQT4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004599 ! EXOSC5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006482 ! exosc5-cdk5rap1 physical interaction relationship: transforms_into CCO:B0011812 ! EXOS5_HUMAN-Phosphoserine20 relationship: transforms_into CCO:B0011813 ! EXOS5_HUMAN-Phosphoserine27 [Term] id: CCO:B0005556 name: EXOS8_HUMAN def: "Exosome complex exonuclease RRP43" [UniProtKB:Q96B26] synonym: "EC 3.1.13.-" EXACT [UniProtKB:Q96B26] synonym: "Exosome component 8" EXACT [UniProtKB:Q96B26] synonym: "Opa-interacting protein 2" EXACT [UniProtKB:Q96B26] synonym: "p9" EXACT [UniProtKB:Q96B26] synonym: "Ribosomal RNA-processing protein 43" EXACT [UniProtKB:Q96B26] xref: EMBL:AAC39558.1 xref: EMBL:AAH20773.1 xref: UniProtKB:O43480 xref: UniProtKB:Q96B26 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004600 ! EXOSC8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006483 ! exosc8-ches1 physical interaction [Term] id: CCO:B0005557 name: EXOS3_HUMAN def: "Exosome complex exonuclease RRP40" [UniProtKB:Q9NQT5] synonym: "EC 3.1.13.-" EXACT [UniProtKB:Q9NQT5] synonym: "Exosome component 3" EXACT [UniProtKB:Q9NQT5] synonym: "p10" EXACT [UniProtKB:Q9NQT5] synonym: "Ribosomal RNA-processing protein 40" EXACT [UniProtKB:Q9NQT5] xref: EMBL:AAD34097.1 xref: EMBL:AAF82133.1 xref: EMBL:AAH02437.1 xref: EMBL:AAH08880.1 xref: UniProtKB:Q9NQT5 xref: UniProtKB:Q9Y3A8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004597 ! EXOSC3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006484 ! exosc3-cdk5rap1 physical interaction relationship: transforms_into CCO:B0011810 ! EXOS3_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005559 name: SNX9_HUMAN def: "Sorting nexin-9" [UniProtKB:Q9Y5X1] synonym: "Protein SDP1" EXACT [UniProtKB:Q9Y5X1] synonym: "SH3 and PX domain-containing protein 1" EXACT [UniProtKB:Q9Y5X1] synonym: "SH3 and PX domain-containing protein 3A" EXACT [UniProtKB:Q9Y5X1] xref: EMBL:AAD27832.1 xref: EMBL:AAD43001.1 xref: EMBL:AAF04473.1 xref: EMBL:AAH01084.3 xref: EMBL:AAH05022.1 xref: EMBL:AAL54871.1 xref: EMBL:CAI12979.1 xref: EMBL:CAI15180.1 xref: EMBL:CAI20465.1 xref: UniProtKB:Q9BSI7 xref: UniProtKB:Q9BVM1 xref: UniProtKB:Q9UJH6 xref: UniProtKB:Q9UP20 xref: UniProtKB:Q9Y5X1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005647 ! SNX9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006486 ! mphosph6-snx9 physical interaction relationship: transforms_into CCO:B0014151 ! SNX9_HUMAN-Phosphoserine176 [Term] id: CCO:B0005561 name: T4AF1_HUMAN def: "Putative TRAF4-associated factor 1" [UniProtKB:Q9Y448] xref: EMBL:AAD24201.1 xref: EMBL:AAH04543.1 xref: EMBL:AAH14060.1 xref: EMBL:AAH45739.1 xref: EMBL:AAH64344.1 xref: EMBL:AAI07803.1 xref: EMBL:AAI18560.1 xref: EMBL:AAI18640.1 xref: EMBL:AAT66172.1 xref: UniProtKB:Q147U5 xref: UniProtKB:Q32Q57 xref: UniProtKB:Q5ISJ0 xref: UniProtKB:Q6P2S5 xref: UniProtKB:Q6PJM0 xref: UniProtKB:Q86XB4 xref: UniProtKB:Q9Y448 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005718 ! TRAF4AF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006488 ! mphosph6-q9y448 physical interaction [Term] id: CCO:B0005562 name: DLRB1_HUMAN def: "Dynein light chain roadblock-type 1" [UniProtKB:Q9NP97] synonym: "Bithoraxoid-like protein" EXACT [UniProtKB:Q9NP97] synonym: "BLP" EXACT [UniProtKB:Q9NP97] synonym: "Dynein light chain 2A, cytoplasmic" EXACT [UniProtKB:Q9NP97] synonym: "Dynein-associated protein Km23" EXACT [UniProtKB:Q9NP97] xref: EMBL:AAF29126.1 xref: EMBL:AAF86646.1 xref: EMBL:AAH02481.1 xref: EMBL:AAK18712.1 xref: EMBL:AAK95342.1 xref: EMBL:AAL75951.1 xref: EMBL:CAI21456.1 xref: EMBL:CAI23308.1 xref: UniProtKB:Q5TC72 xref: UniProtKB:Q96IV3 xref: UniProtKB:Q9NP97 xref: UniProtKB:Q9NQM2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004482 ! DYNLRB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006489 ! mphosph6-dncl2a physical interaction relationship: transforms_into CCO:B0011543 ! DLRB1_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005563 name: RS20_HUMAN def: "40S ribosomal protein S20" [UniProtKB:P60866] xref: EMBL:AAA60286.1 xref: EMBL:AAH07507.1 xref: EMBL:AAH87850.1 xref: EMBL:BAA25820.1 xref: EMBL:BAB79480.1 xref: UniProtKB:P17075 xref: UniProtKB:P60866 xref: UniProtKB:Q5M8S9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005534 ! RPS20_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006490 ! mphosph6-rps20 physical interaction relationship: transforms_into CCO:B0013939 ! RS20_HUMAN-Phosphothreonine9 [Term] id: CCO:B0005564 name: RHG18_HUMAN def: "Rho GTPase-activating protein 18" [UniProtKB:Q8N392] synonym: "MacGAP" EXACT [UniProtKB:Q8N392] synonym: "Rho-type GTPase-activating protein 18" EXACT [UniProtKB:Q8N392] xref: EMBL:AAH17223.1 xref: EMBL:AAH39611.1 xref: EMBL:AAH62417.1 xref: EMBL:AAI01709.1 xref: EMBL:AAI07417.1 xref: EMBL:AAI11941.1 xref: EMBL:BAB61887.1 xref: EMBL:CAD39167.2 xref: EMBL:CAH72298.1 xref: UniProtKB:Q58EZ3 xref: UniProtKB:Q6P679 xref: UniProtKB:Q6PJD7 xref: UniProtKB:Q8N392 xref: UniProtKB:Q96S64 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005482 ! ARHGAP18_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006493 ! mphosph6-dkfzp762i16 physical interaction [Term] id: CCO:B0005565 name: SKIV2_HUMAN def: "Helicase SKI2W" [UniProtKB:Q15477] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q15477] synonym: "Helicase-like protein" EXACT [UniProtKB:Q15477] synonym: "HLP" EXACT [UniProtKB:Q15477] xref: EMBL:AAB52523.1 xref: EMBL:AAB67978.1 xref: EMBL:CAA67024.1 xref: EMBL:CAA88733.1 xref: UniProtKB:O15005 xref: UniProtKB:Q12902 xref: UniProtKB:Q15476 xref: UniProtKB:Q15477 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005621 ! SKIV2L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006494 ! skiv2l-cdc2l2 physical interaction relationship: transforms_into CCO:B0014064 ! SKIV2_HUMAN-Phosphoserine245 relationship: transforms_into CCO:B0014065 ! SKIV2_HUMAN-Phosphoserine256 relationship: transforms_into CCO:B0014066 ! SKIV2_HUMAN-Phosphoserine366 [Term] id: CCO:B0005566 name: LSM3_HUMAN def: "U6 snRNA-associated Sm-like protein LSm3" [UniProtKB:P62310] xref: EMBL:AAD56227.1 xref: EMBL:AAG14954.1 xref: EMBL:AAH07055.1 xref: EMBL:CAB45866.1 xref: UniProtKB:P62310 xref: UniProtKB:Q9Y4Z1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004992 ! LSM3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006495 ! lsm3-xpc physical interaction relationship: transforms_into CCO:B0012707 ! LSM3_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005568 name: TR112_HUMAN def: "TRM112-like protein" [UniProtKB:Q9UI30] xref: EMBL:AAF14857.1 xref: EMBL:AAF29116.1 xref: EMBL:AAF82266.1 xref: EMBL:AAH17172.1 xref: EMBL:AAH29482.1 xref: EMBL:AAI05295.1 xref: UniProtKB:Q3MHC7 xref: UniProtKB:Q8N2Z4 xref: UniProtKB:Q9UI30 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005820 ! AD-001_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006499 ! rent1-u315 physical interaction [Term] id: CCO:B0005569 name: PKHB2_HUMAN def: "Pleckstrin homology domain-containing family B member 2" [UniProtKB:Q96CS7] synonym: "Evectin-2" EXACT [UniProtKB:Q96CS7] xref: EMBL:AAH01428.1 xref: EMBL:AAH13991.1 xref: EMBL:AAH50695.2 xref: EMBL:BAA91379.1 xref: UniProtKB:Q86W37 xref: UniProtKB:Q96CS7 xref: UniProtKB:Q9BV75 xref: UniProtKB:Q9NWK1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005326 ! PLEKHB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006500 ! rent1-plekhb2 physical interaction relationship: participates_in CCO:I0008807 ! psmd14-plekhb2 physical interaction [Term] id: CCO:B0005570 name: ACSA_HUMAN def: "Acetyl-coenzyme A synthetase, cytoplasmic" [UniProtKB:Q9NR19] synonym: "AceCS" EXACT [UniProtKB:Q9NR19] synonym: "Acetate--CoA ligase" EXACT [UniProtKB:Q9NR19] synonym: "Acetyl-CoA synthetase" EXACT [UniProtKB:Q9NR19] synonym: "ACS" EXACT [UniProtKB:Q9NR19] synonym: "Acyl-activating enzyme" EXACT [UniProtKB:Q9NR19] synonym: "Acyl-CoA synthetase short-chain family member 2" EXACT [UniProtKB:Q9NR19] synonym: "EC 6.2.1.1" EXACT [UniProtKB:Q9NR19] xref: EMBL:AAF75064.1 xref: EMBL:AAH12172.1 xref: EMBL:CAI19312.1 xref: EMBL:CAI19726.1 xref: UniProtKB:Q5QPH2 xref: UniProtKB:Q96EL0 xref: UniProtKB:Q9NQP7 xref: UniProtKB:Q9NR19 xref: UniProtKB:Q9UJ15 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004018 ! ACSS2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006501 ! rent1-acas2 physical interaction relationship: transforms_into CCO:B0010434 ! ACSA_HUMAN-Phosphoserine30 relationship: transforms_into CCO:B0010435 ! ACSA_HUMAN-Phosphoserine263 relationship: transforms_into CCO:B0010436 ! ACSA_HUMAN-Phosphoserine267 [Term] id: CCO:B0005571 name: BAT5_HUMAN def: "Protein BAT5" [UniProtKB:O95870] synonym: "HLA-B-associated transcript 5" EXACT [UniProtKB:O95870] synonym: "Protein G5" EXACT [UniProtKB:O95870] xref: EMBL:AAD18079.1 xref: EMBL:AAG22475.1 xref: EMBL:AAH31839.1 xref: EMBL:BAA91553.1 xref: EMBL:BAB14455.1 xref: EMBL:BAB63383.1 xref: EMBL:CAI17808.2 xref: EMBL:CAI18401.2 xref: EMBL:CAI18530.1 xref: EMBL:CAM26084.1 xref: EMBL:CAM45793.1 xref: UniProtKB:A2BEY3 xref: UniProtKB:O95870 xref: UniProtKB:Q5SRR1 xref: UniProtKB:Q5SRR2 xref: UniProtKB:Q8WYH0 xref: UniProtKB:Q9NW33 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004141 ! BAT5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006502 ! rent1-bat5 physical interaction [Term] id: CCO:B0005572 name: GNPTG_HUMAN def: "N-acetylglucosamine-1-phosphotransferase subunit gamma precursor" [UniProtKB:Q9UJJ9] synonym: "GlcNAc-1-phosphotransferase subunit gamma" EXACT [UniProtKB:Q9UJJ9] synonym: "UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma" EXACT [UniProtKB:Q9UJJ9] xref: EMBL:AAG27706.1 xref: EMBL:AAH14592.1 xref: EMBL:AAP34456.1 xref: EMBL:CAB56184.1 xref: UniProtKB:Q6XYD7 xref: UniProtKB:Q96L13 xref: UniProtKB:Q9UJJ9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004713 ! GNPTG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006504 ! rent1-c316g12_3 physical interaction [Term] id: CCO:B0005573 name: MED10_HUMAN def: "Mediator of RNA polymerase II transcription subunit 10" [UniProtKB:Q9BTT4] synonym: "Mediator complex subunit 10" EXACT [UniProtKB:Q9BTT4] synonym: "Transformation-related gene 17 protein" EXACT [UniProtKB:Q9BTT4] synonym: "Transformation-related gene 20 protein" EXACT [UniProtKB:Q9BTT4] synonym: "TRG-17" EXACT [UniProtKB:Q9BTT4] synonym: "TRG-20" EXACT [UniProtKB:Q9BTT4] xref: EMBL:AAH03353.1 xref: EMBL:AAQ18038.1 xref: EMBL:AAS47514.1 xref: EMBL:AAT06736.1 xref: EMBL:EAX08110.1 xref: UniProtKB:Q9BTT4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005054 ! MED10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006505 ! q9btt4-q71f56-1 physical interaction [Term] id: CCO:B0005574 name: MED29_HUMAN def: "Mediator of RNA polymerase II transcription subunit 29" [UniProtKB:Q9NX70] synonym: "Intersex-like protein" EXACT [UniProtKB:Q9NX70] synonym: "Mediator complex subunit 29" EXACT [UniProtKB:Q9NX70] xref: EMBL:AAH19015.1 xref: EMBL:AAU43732.1 xref: EMBL:BAA91147.1 xref: EMBL:CAB70687.2 xref: UniProtKB:Q5XX09 xref: UniProtKB:Q9NTF4 xref: UniProtKB:Q9NX70 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005072 ! MED29_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006507 ! q9nx70-q71f56-1 physical interaction [Term] id: CCO:B0005576 name: FANCE_HUMAN def: "Fanconi anemia group E protein" [UniProtKB:Q9HB96] synonym: "Protein FACE" EXACT [UniProtKB:Q9HB96] xref: EMBL:AAG16743.1 xref: EMBL:AAH46359.1 xref: EMBL:AAY26395.1 xref: EMBL:CAD92504.1 xref: UniProtKB:Q4ZGH2 xref: UniProtKB:Q9HB96 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004609 ! FANCE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006509 ! fance-fancd2-2 physical interaction relationship: participates_in CCO:I0006611 ! fancd2-fance-1 physical interaction relationship: participates_in CCO:I0007402 ! fance-fanca-1 physical interaction relationship: participates_in CCO:I0007403 ! fance-fanca-2 physical interaction relationship: participates_in CCO:I0007404 ! fance-fancd2-1 physical interaction [Term] id: CCO:B0005578 name: ZN655_HUMAN def: "Zinc finger protein 655" [UniProtKB:Q8N720] synonym: "Vav-interacting Krueppel-like protein" EXACT [UniProtKB:Q8N720] xref: EMBL:AAH11816.1 xref: EMBL:AAH24770.1 xref: EMBL:AAH37407.1 xref: EMBL:AAM33786.1 xref: UniProtKB:Q8IV00 xref: UniProtKB:Q8N720 xref: UniProtKB:Q8TA89 xref: UniProtKB:Q96EZ3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005966 ! ZNF655_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006525 ! zn655-cdk4-2 physical interaction relationship: participates_in CCO:I0006526 ! zn655-cdk4-3 physical interaction relationship: participates_in CCO:I0007424 ! zn655-cdk4-1 physical interaction [Term] id: CCO:B0005579 name: PIAS1_HUMAN def: "E3 SUMO-protein ligase PIAS1" [UniProtKB:O75925] synonym: "DEAD/H box-binding protein 1" EXACT [UniProtKB:O75925] synonym: "GBP" EXACT [UniProtKB:O75925] synonym: "Gu-binding protein" EXACT [UniProtKB:O75925] synonym: "Protein inhibitor of activated STAT protein 1" EXACT [UniProtKB:O75925] synonym: "RNA helicase II-binding protein" EXACT [UniProtKB:O75925] xref: EMBL:AAB58488.1 xref: EMBL:AAC36702.1 xref: EMBL:AAD49722.1 xref: EMBL:AAI18588.1 xref: EMBL:AAI21798.1 xref: UniProtKB:O75925 xref: UniProtKB:Q147X4 xref: UniProtKB:Q99751 xref: UniProtKB:Q9UN02 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005310 ! PIAS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006529 ! pias1-p53-1 direct interaction relationship: participates_in CCO:I0006530 ! pias1-p53-2 direct interaction relationship: participates_in CCO:I0006531 ! pias1-p53-3 direct interaction relationship: transforms_into CCO:B0013506 ! PIAS1_HUMAN-Phosphoserine466 relationship: transforms_into CCO:B0013507 ! PIAS1_HUMAN-Phosphoserine467 relationship: transforms_into CCO:B0013508 ! PIAS1_HUMAN-Phosphoserine468 relationship: transforms_into CCO:B0013509 ! PIAS1_HUMAN-Phosphoserine483 relationship: transforms_into CCO:B0013510 ! PIAS1_HUMAN-Phosphoserine485 relationship: transforms_into CCO:B0013511 ! PIAS1_HUMAN-Phosphothreonine487 [Term] id: CCO:B0005580 name: HS90B_HUMAN def: "Heat shock protein HSP 90-beta" [UniProtKB:P08238] synonym: "HSP 84" EXACT [UniProtKB:P08238] synonym: "HSP 90" EXACT [UniProtKB:P08238] xref: EMBL:AAA36025.1 xref: EMBL:AAA36026.1 xref: EMBL:AAD14062.1 xref: EMBL:AAF82792.1 xref: EMBL:AAH04928.1 xref: EMBL:AAH09206.2 xref: EMBL:AAH12807.1 xref: EMBL:AAH14485.1 xref: EMBL:AAH16753.1 xref: EMBL:AAH68474.1 xref: EMBL:AAQ63401.1 xref: EMBL:ABC40731.1 xref: EMBL:CAB66478.1 xref: EMBL:CAI20095.1 xref: UniProtKB:P08238 xref: UniProtKB:Q5T9W7 xref: UniProtKB:Q9NQW0 xref: UniProtKB:Q9NTK6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004831 ! HSP90AB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006537 ! hspcb-aars physical interaction relationship: participates_in CCO:I0006872 ! eif2ak1-cdc37-8 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007800 ! hspcb-chk1-1 physical interaction relationship: transforms_into CCO:B0012268 ! HS90B_HUMAN-Phosphoserine226 relationship: transforms_into CCO:B0012269 ! HS90B_HUMAN-Phosphoserine255 relationship: transforms_into CCO:B0012270 ! HS90B_HUMAN-Phosphoserine261 relationship: transforms_into CCO:B0012271 ! HS90B_HUMAN-Phosphothreonine297 relationship: transforms_into CCO:B0012272 ! HS90B_HUMAN-Phosphotyrosine484 relationship: transforms_into CCO:B0012273 ! HS90B_HUMAN-N6-acetyllysine624 relationship: transforms_into CCO:B0031333 ! HS90B_HUMAN-Phosphotyrosine305 [Term] id: CCO:B0005582 name: CAZA2_HUMAN def: "F-actin-capping protein subunit alpha-2" [UniProtKB:P47755] synonym: "CapZ alpha-2" EXACT [UniProtKB:P47755] xref: EMBL:AAA88848.1 xref: EMBL:AAC00534.1 xref: EMBL:AAC60382.1 xref: EMBL:AAH05338.1 xref: EMBL:AAP35381.1 xref: UniProtKB:P47755 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004226 ! CAPZA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006540 ! apc-ctbb1-1 physical interaction relationship: transforms_into CCO:B0041285 ! CAZA2_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005583 name: SC23A_HUMAN def: "Protein transport protein Sec23A" [UniProtKB:Q15436] synonym: "SEC23-related protein A" EXACT [UniProtKB:Q15436] xref: EMBL:AAH36649.1 xref: EMBL:CAA65774.1 xref: UniProtKB:Q15436 xref: UniProtKB:Q8NE16 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005569 ! SEC23A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006540 ! apc-ctbb1-1 physical interaction [Term] id: CCO:B0005584 name: DDB1_HUMAN def: "DNA damage-binding protein 1" [UniProtKB:Q16531] synonym: "Damage-specific DNA-binding protein 1" EXACT [UniProtKB:Q16531] synonym: "DDB p127 subunit" EXACT [UniProtKB:Q16531] synonym: "DDBa" EXACT [UniProtKB:Q16531] synonym: "DNA damage-binding protein a" EXACT [UniProtKB:Q16531] synonym: "HBV X-associated protein 1" EXACT [UniProtKB:Q16531] synonym: "UV-damaged DNA-binding factor" EXACT [UniProtKB:Q16531] synonym: "UV-damaged DNA-binding protein 1" EXACT [UniProtKB:Q16531] synonym: "UV-DDB 1" EXACT [UniProtKB:Q16531] synonym: "XAP-1" EXACT [UniProtKB:Q16531] synonym: "Xeroderma pigmentosum group E-complementing protein" EXACT [UniProtKB:Q16531] synonym: "XPCe" EXACT [UniProtKB:Q16531] synonym: "XPE-BF" EXACT [UniProtKB:Q16531] synonym: "XPE-binding factor" EXACT [UniProtKB:Q16531] xref: EMBL:AAA62838.1 xref: EMBL:AAA88883.1 xref: EMBL:AAC50349.1 xref: EMBL:AAH11686.1 xref: EMBL:AAH50530.1 xref: EMBL:AAH51764.1 xref: EMBL:AAX44048.1 xref: EMBL:CAA05770.1 xref: EMBL:EAW73935.1 xref: UniProtKB:A6NG77 xref: UniProtKB:O15176 xref: UniProtKB:Q13289 xref: UniProtKB:Q16531 xref: UniProtKB:Q58F96 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004450 ! DDB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006540 ! apc-ctbb1-1 physical interaction relationship: participates_in CCO:I0006808 ! cul4b-ddb1-2 physical interaction relationship: participates_in CCO:I0006809 ! cul4b-tle2 physical interaction relationship: participates_in CCO:I0006810 ! ddb1-ddb2-1 physical interaction relationship: participates_in CCO:I0006812 ! cul4a-cul4b physical interaction relationship: participates_in CCO:I0006813 ! cul4a-eed physical interaction relationship: participates_in CCO:I0006814 ! cul4a-cul4b-1 physical interaction relationship: participates_in CCO:I0006817 ! l2dtl-cul4b physical interaction relationship: participates_in CCO:I0006818 ! tle2-ddb1-1 physical interaction relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction relationship: participates_in CCO:I0007514 ! h3_peptide-cul4a physical interaction relationship: participates_in CCO:I0008518 ! ikbkg-ddb1 physical interaction relationship: participates_in CCO:I0008519 ! map3k1-ddb1 physical interaction relationship: participates_in CCO:I0008520 ! map3k3-ddb1 physical interaction relationship: participates_in CCO:I0008521 ! tnfrsf1b-ddb1 physical interaction relationship: participates_in CCO:I0008522 ! tle2-ddb1 physical interaction relationship: participates_in CCO:I0008523 ! ddb1-ddb2 physical interaction relationship: participates_in CCO:I0008524 ! rbbp5-wdr5-1 physical interaction relationship: participates_in CCO:I0008525 ! l2dt1-ddb1 physical interaction relationship: participates_in CCO:I0008526 ! eed-ddb1 physical interaction relationship: participates_in CCO:I0008527 ! ddb1-brap physical interaction relationship: participates_in CCO:I0008528 ! ddb1-cops3 physical interaction relationship: participates_in CCO:I0008529 ! cop1-ddb1 physical interaction relationship: participates_in CCO:I0008530 ! l2dtl-ddb1 physical interaction relationship: participates_in CCO:I0008531 ! wdr57-ddb1 physical interaction relationship: participates_in CCO:I0008532 ! wdr26-ddb1 physical interaction relationship: participates_in CCO:I0008533 ! wdr5b-ddb1 physical interaction relationship: participates_in CCO:I0008534 ! wdr5-ddb1 physical interaction relationship: participates_in CCO:I0008535 ! vamp3-ddb1 physical interaction relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: transforms_into CCO:B0011454 ! DDB1_HUMAN-Phosphothreonine8 relationship: transforms_into CCO:B0011455 ! DDB1_HUMAN-Phosphoserine757 relationship: transforms_into CCO:B0011456 ! DDB1_HUMAN-Phosphoserine766 [Term] id: CCO:B0005585 name: TIF1B_HUMAN def: "Transcription intermediary factor 1-beta" [UniProtKB:Q13263] synonym: "KAP-1" EXACT [UniProtKB:Q13263] synonym: "KRAB-associated protein 1" EXACT [UniProtKB:Q13263] synonym: "KRAB-interacting protein 1" EXACT [UniProtKB:Q13263] synonym: "KRIP-1" EXACT [UniProtKB:Q13263] synonym: "Nuclear corepressor KAP-1" EXACT [UniProtKB:Q13263] synonym: "RING finger protein 96" EXACT [UniProtKB:Q13263] synonym: "TIF1-beta" EXACT [UniProtKB:Q13263] synonym: "Tripartite motif-containing protein 28" EXACT [UniProtKB:Q13263] xref: EMBL:AAA74954.1 xref: EMBL:AAB37341.1 xref: EMBL:AAB51517.1 xref: EMBL:AAH04978.1 xref: EMBL:AAH07390.2 xref: EMBL:AAH52986.1 xref: EMBL:CAA66150.1 xref: UniProtKB:O00677 xref: UniProtKB:Q13263 xref: UniProtKB:Q7Z632 xref: UniProtKB:Q93040 xref: UniProtKB:Q96IM1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005781 ! TRIM28_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006540 ! apc-ctbb1-1 physical interaction relationship: transforms_into CCO:B0014362 ! TIF1B_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0014363 ! TIF1B_HUMAN-Phosphoserine19 relationship: transforms_into CCO:B0014364 ! TIF1B_HUMAN-Phosphoserine50 relationship: transforms_into CCO:B0014365 ! TIF1B_HUMAN-Phosphoserine440 relationship: transforms_into CCO:B0014366 ! TIF1B_HUMAN-Phosphoserine466 relationship: transforms_into CCO:B0014367 ! TIF1B_HUMAN-Phosphoserine471 relationship: transforms_into CCO:B0014368 ! TIF1B_HUMAN-Phosphoserine473 relationship: transforms_into CCO:B0014369 ! TIF1B_HUMAN-Phosphoserine501 relationship: transforms_into CCO:B0014370 ! TIF1B_HUMAN-Phosphothreonine541 relationship: transforms_into CCO:B0014371 ! TIF1B_HUMAN-Phosphoserine594 relationship: transforms_into CCO:B0014372 ! TIF1B_HUMAN-Phosphoserine681 relationship: transforms_into CCO:B0014373 ! TIF1B_HUMAN-Phosphoserine683 relationship: transforms_into CCO:B0014374 ! TIF1B_HUMAN-Phosphoserine757 relationship: transforms_into CCO:B0014375 ! TIF1B_HUMAN-Phosphoserine824 [Term] id: CCO:B0005586 name: DSS1_HUMAN def: "26 proteasome complex subunit DSS1" [UniProtKB:P60896] synonym: "Deleted in split hand/split foot protein 1" EXACT [UniProtKB:P60896] synonym: "Split hand/foot deleted protein 1" EXACT [UniProtKB:P60896] synonym: "Split hand/foot malformation type 1 protein" EXACT [UniProtKB:P60896] xref: EMBL:AAA91179.1 xref: EMBL:AAH32782.1 xref: EMBL:AAQ93368.1 xref: UniProtKB:P60896 xref: UniProtKB:Q13437 xref: UniProtKB:Q61067 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004514 ! SHFM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006543 ! brca2-shfdg1-2 physical interaction relationship: participates_in CCO:I0006670 ! brca2-shfdg1-3 physical interaction relationship: participates_in CCO:I0006671 ! shfdg1-brca2-3 physical interaction relationship: participates_in CCO:I0007133 ! brca2-shfdg1-1 physical interaction [Term] id: CCO:B0005587 name: TOP1_HUMAN def: "DNA topoisomerase 1" [UniProtKB:P11387] synonym: "DNA topoisomerase I" EXACT [UniProtKB:P11387] synonym: "EC 5.99.1.2" EXACT [UniProtKB:P11387] xref: EMBL:AAA61206.1 xref: EMBL:AAA61207.1 xref: EMBL:AAA61208.1 xref: EMBL:AAB60379.1 xref: EMBL:AAB60380.1 xref: EMBL:CAA34500.2 xref: EMBL:CAA36834.1 xref: EMBL:CAI19767.1 xref: EMBL:CAI42886.1 xref: UniProtKB:O43256 xref: UniProtKB:P11387 xref: UniProtKB:Q12855 xref: UniProtKB:Q12856 xref: UniProtKB:Q15610 xref: UniProtKB:Q5TFY3 xref: UniProtKB:Q9UJN0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005810 ! TOP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006548 ! top1-npm1 physical interaction relationship: participates_in CCO:I0006549 ! top1-hnrpc physical interaction relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: participates_in CCO:I0007786 ! top1-2 physical interaction [Term] id: CCO:B0005588 name: AKAP9_HUMAN def: "A-kinase anchor protein 9" [UniProtKB:Q99996] synonym: "A-kinase anchor protein 350 kDa" EXACT [UniProtKB:Q99996] synonym: "A-kinase anchor protein 450 kDa" EXACT [UniProtKB:Q99996] synonym: "AKAP 120-like protein" EXACT [UniProtKB:Q99996] synonym: "AKAP 350" EXACT [UniProtKB:Q99996] synonym: "AKAP 450" EXACT [UniProtKB:Q99996] synonym: "Centrosome- and Golgi-localized PKN-associated protein" EXACT [UniProtKB:Q99996] synonym: "CG-NAP" EXACT [UniProtKB:Q99996] synonym: "hgAKAP 350" EXACT [UniProtKB:Q99996] synonym: "PRKA9" EXACT [UniProtKB:Q99996] synonym: "Protein hyperion" EXACT [UniProtKB:Q99996] synonym: "Protein kinase A-anchoring protein 9" EXACT [UniProtKB:Q99996] synonym: "Protein yotiao" EXACT [UniProtKB:Q99996] xref: EMBL:AAB86384.1 xref: EMBL:AAB96867.2 xref: EMBL:AAC60380.1 xref: EMBL:AAD22767.1 xref: EMBL:AAD39719.1 xref: EMBL:AAS07419.1 xref: EMBL:BAA34523.1 xref: EMBL:BAA78718.1 xref: EMBL:CAA09361.1 xref: EMBL:CAB40713.1 xref: UniProtKB:O14869 xref: UniProtKB:O43355 xref: UniProtKB:O94895 xref: UniProtKB:Q75N20 xref: UniProtKB:Q99996 xref: UniProtKB:Q9UQH3 xref: UniProtKB:Q9UQQ4 xref: UniProtKB:Q9Y6B8 xref: UniProtKB:Q9Y6Y2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004043 ! AKAP9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006568 ! cdc5l-akap9 physical interaction relationship: transforms_into CCO:B0010486 ! AKAP9_HUMAN-Phosphoserine3869 [Term] id: CCO:B0005589 name: LSD1_HUMAN def: "Lysine-specific histone demethylase 1" [UniProtKB:O60341] synonym: "BRAF35-HDAC complex protein BHC110" EXACT [UniProtKB:O60341] synonym: "EC 1.-.-.-" EXACT [UniProtKB:O60341] synonym: "Flavin-containing amine oxidase domain-containing protein 2" EXACT [UniProtKB:O60341] xref: EMBL:AAH16639.1 xref: EMBL:AAH25362.1 xref: EMBL:AAH40194.3 xref: EMBL:AAH48134.2 xref: EMBL:BAA25527.1 xref: EMBL:CAD38675.2 xref: EMBL:CAI19707.2 xref: EMBL:CAI19708.2 xref: UniProtKB:O60341 xref: UniProtKB:Q5TH94 xref: UniProtKB:Q5TH95 xref: UniProtKB:Q86VT7 xref: UniProtKB:Q8IXK4 xref: UniProtKB:Q8NDP6 xref: UniProtKB:Q8TAZ3 xref: UniProtKB:Q96AW4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004990 ! AOF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006569 ! cdc5l-aof2 physical interaction relationship: transforms_into CCO:B0012706 ! LSD1_HUMAN-Phosphoserine166 [Term] id: CCO:B0005590 name: CEP63_HUMAN def: "Centrosomal protein of 63 kDa" [UniProtKB:Q96MT8] synonym: "Cep63" EXACT [UniProtKB:Q96MT8] xref: EMBL:AAH14050.1 xref: EMBL:AAH68997.1 xref: EMBL:BAB14578.1 xref: EMBL:BAB14662.1 xref: EMBL:BAB71192.1 xref: EMBL:DAA05503.1 xref: UniProtKB:Q96CR0 xref: UniProtKB:Q96MT8 xref: UniProtKB:Q9H8F5 xref: UniProtKB:Q9H8N0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004330 ! CEP63_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006578 ! cep63-cspg6 physical interaction [Term] id: CCO:B0005591 name: DISC1_HUMAN def: "Disrupted in schizophrenia 1 protein" [UniProtKB:Q9NRI5] xref: EMBL:AAF73874.1 xref: EMBL:AAF73877.1 xref: EMBL:AAF73889.1 xref: EMBL:BAA32302.1 xref: EMBL:CAD44628.1 xref: EMBL:CAD44631.1 xref: EMBL:CAH70955.1 xref: EMBL:CAH70956.1 xref: EMBL:CAH70957.1 xref: EMBL:CAI15677.1 xref: EMBL:CAI15679.1 xref: EMBL:CAI17204.1 xref: EMBL:CAI17206.1 xref: EMBL:CAI17207.1 xref: EMBL:CAI21886.1 xref: EMBL:CAI21888.1 xref: EMBL:CAI22543.1 xref: EMBL:CAI23013.1 xref: UniProtKB:O75045 xref: UniProtKB:Q5VT44 xref: UniProtKB:Q5VT45 xref: UniProtKB:Q8IXJ0 xref: UniProtKB:Q8IXJ1 xref: UniProtKB:Q9BX19 xref: UniProtKB:Q9NRI3 xref: UniProtKB:Q9NRI4 xref: UniProtKB:Q9NRI5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004474 ! DISC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006572 ! disc1-cdc5l physical interaction relationship: participates_in CCO:I0006573 ! disc1-cdc5l-1 physical interaction relationship: participates_in CCO:I0006575 ! disc1-cdk5rap3-1 physical interaction relationship: participates_in CCO:I0006576 ! disc1-cdk5rap3-2 physical interaction relationship: participates_in CCO:I0006579 ! disc1-dnch1 physical interaction relationship: participates_in CCO:I0006580 ! disc1-dnch1-2 physical interaction relationship: participates_in CCO:I0006589 ! disc1-macf1 physical interaction relationship: participates_in CCO:I0006590 ! disc1-macf1-2 physical interaction relationship: participates_in CCO:I0006591 ! disc1-macf1-3 physical interaction relationship: participates_in CCO:I0006592 ! disc1-macf1-4 physical interaction relationship: participates_in CCO:I0006596 ! disc1-pafah1b1 physical interaction relationship: participates_in CCO:I0006597 ! disc1-pafah1b1-1 physical interaction relationship: participates_in CCO:I0006601 ! disc1-rad21 physical interaction relationship: participates_in CCO:I0006602 ! disc1-smc2l1 physical interaction relationship: participates_in CCO:I0006723 ! disc1-tubg colocalization relationship: participates_in CCO:I0006799 ! disc1-cdk5rap3 physical interaction relationship: participates_in CCO:I0006800 ! disc1-dctn1 physical interaction relationship: participates_in CCO:I0006801 ! disc1-dnch1-1 physical interaction relationship: participates_in CCO:I0006802 ! disc1-macf1-1 physical interaction relationship: participates_in CCO:I0006803 ! disc1-ppp5c physical interaction relationship: participates_in CCO:I0007970 ! disc1-tubg-1 physical interaction [Term] id: CCO:B0005592 name: EXOC1_HUMAN def: "Exocyst complex component 1" [UniProtKB:Q9NV70] synonym: "Exocyst complex component Sec3" EXACT [UniProtKB:Q9NV70] xref: EMBL:AAF64268.1 xref: EMBL:AAH20650.1 xref: EMBL:AAH94751.1 xref: EMBL:BAA91886.1 xref: EMBL:BAB55095.1 xref: UniProtKB:Q504V4 xref: UniProtKB:Q8WUE7 xref: UniProtKB:Q96T15 xref: UniProtKB:Q9NV70 xref: UniProtKB:Q9NZE4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004595 ! EXOC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006574 ! exoc1-nuf2 physical interaction relationship: participates_in CCO:I0006594 ! exoc1-macf1 physical interaction [Term] id: CCO:B0005593 name: CRNL1_HUMAN def: "Crooked neck-like protein 1" [UniProtKB:Q9BZJ0] synonym: "Crooked neck homolog" EXACT [UniProtKB:Q9BZJ0] synonym: "hCrn" EXACT [UniProtKB:Q9BZJ0] xref: EMBL:AAF65571.2 xref: EMBL:AAK01924.1 xref: EMBL:AAK01925.1 xref: EMBL:AAK01926.1 xref: EMBL:AAK01927.1 xref: EMBL:AAL39004.1 xref: EMBL:BAB14303.1 xref: EMBL:BAB14485.1 xref: EMBL:BAB14659.1 xref: EMBL:CAI42113.1 xref: UniProtKB:Q5JY64 xref: UniProtKB:Q8WYI5 xref: UniProtKB:Q9BZI9 xref: UniProtKB:Q9BZJ0 xref: UniProtKB:Q9BZJ1 xref: UniProtKB:Q9BZJ2 xref: UniProtKB:Q9GZW7 xref: UniProtKB:Q9H8F8 xref: UniProtKB:Q9NQH5 xref: UniProtKB:Q9NYD8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004398 ! CRNKL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006577 ! cdc5l-crnkl1 physical interaction [Term] id: CCO:B0005594 name: HOOK1_HUMAN def: "Hook homolog 1" [UniProtKB:Q9UJC3] synonym: "h-hook1" EXACT [UniProtKB:Q9UJC3] synonym: "hHK1" EXACT [UniProtKB:Q9UJC3] xref: EMBL:AAC09298.1 xref: EMBL:AAH11621.1 xref: EMBL:CAI22779.1 xref: UniProtKB:O60561 xref: UniProtKB:Q5TG44 xref: UniProtKB:Q9UJC3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004823 ! HOOK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006582 ! cdc5l-hook1 physical interaction relationship: transforms_into CCO:B0012253 ! HOOK1_HUMAN-Phosphoserine235 relationship: transforms_into CCO:B0012254 ! HOOK1_HUMAN-Phosphothreonine699 [Term] id: CCO:B0005595 name: GSE1_HUMAN def: "Genetic suppressor element 1" [UniProtKB:Q14687] xref: EMBL:AAH00753.2 xref: EMBL:AAH09854.2 xref: EMBL:AAH37556.1 xref: EMBL:BAA11499.1 xref: UniProtKB:Q14687 xref: UniProtKB:Q8IY61 xref: UniProtKB:Q96GA4 xref: UniProtKB:Q9BW09 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004734 ! GSE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006583 ! cdc5l-kiaa0182 physical interaction [Term] id: CCO:B0005596 name: K0240_HUMAN def: "Uncharacterized protein KIAA0240" [UniProtKB:Q6AI39] xref: EMBL:BAA13246.2 xref: EMBL:CAH10475.1 xref: EMBL:CAI14820.2 xref: EMBL:CAI21488.2 xref: UniProtKB:Q5TFZ3 xref: UniProtKB:Q6AI39 xref: UniProtKB:Q92514 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004915 ! KIAA0240_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006584 ! cdc5l-kiaa0240 physical interaction [Term] id: CCO:B0005597 name: Q5VVE9_HUMAN def: "Zinc finger protein 451" [UniProtKB:Q5VVE9] xref: EMBL:CAH71222.1 xref: UniProtKB:Q5VVE9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005961 ! ZNF451_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006585 ! cdc5l-znf451 physical interaction [Term] id: CCO:B0005598 name: KIF3C_HUMAN def: "Kinesin-like protein KIF3C" [UniProtKB:O14782] xref: EMBL:AAC05302.1 xref: EMBL:AAC39562.1 xref: EMBL:AAH92406.1 xref: EMBL:AAI30424.1 xref: EMBL:CAA05252.1 xref: EMBL:CAA05253.1 xref: EMBL:CAA05254.1 xref: EMBL:CAA05255.1 xref: EMBL:CAA05256.1 xref: EMBL:CAA05257.1 xref: EMBL:CAA05258.1 xref: UniProtKB:O14782 xref: UniProtKB:O43544 xref: UniProtKB:Q562F7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004949 ! KIF3C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006586 ! cdc5l-kif3c physical interaction relationship: transforms_into CCO:B0012608 ! KIF3C_HUMAN-Phosphothreonine585 [Term] id: CCO:B0005599 name: KINH_HUMAN def: "Kinesin-1 heavy chain" [UniProtKB:P33176] synonym: "Conventional kinesin heavy chain" EXACT [UniProtKB:P33176] synonym: "Ubiquitous kinesin heavy chain" EXACT [UniProtKB:P33176] synonym: "UKHC" EXACT [UniProtKB:P33176] xref: EMBL:AAI26280.1 xref: EMBL:AAI26282.1 xref: EMBL:CAA46703.1 xref: EMBL:CAH71618.1 xref: UniProtKB:A0AVB2 xref: UniProtKB:P33176 xref: UniProtKB:Q5VZ85 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004952 ! KIF5B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006587 ! cdc5l-kif5b physical interaction [Term] id: CCO:B0005600 name: K1267_HUMAN def: "Uncharacterized protein KIAA1267" [UniProtKB:Q7Z3B3] xref: EMBL:AAH06271.1 xref: EMBL:AAH35892.1 xref: EMBL:AAH98376.1 xref: EMBL:BAA86581.1 xref: EMBL:CAB55949.1 xref: EMBL:CAB70694.1 xref: EMBL:CAD97958.1 xref: EMBL:CAH10565.1 xref: UniProtKB:Q6AW85 xref: UniProtKB:Q7Z3B3 xref: UniProtKB:Q8IYH1 xref: UniProtKB:Q9BRH0 xref: UniProtKB:Q9NTE7 xref: UniProtKB:Q9UFT0 xref: UniProtKB:Q9ULF3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004916 ! KIAA1267_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006588 ! cdc5l-kiaa1267 physical interaction relationship: transforms_into CCO:B0012453 ! K1267_HUMAN-Phosphoserine1082 [Term] id: CCO:B0005601 name: MYT1L_HUMAN def: "Myelin transcription factor 1-like protein" [UniProtKB:Q9UL68] synonym: "MyT1-L" EXACT [UniProtKB:Q9UL68] synonym: "MyT1L protein" EXACT [UniProtKB:Q9UL68] xref: EMBL:AAF14051.1 xref: EMBL:AAH71612.1 xref: EMBL:BAA83058.2 xref: UniProtKB:Q6IQ17 xref: UniProtKB:Q9UL68 xref: UniProtKB:Q9UPP6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005152 ! MYT1L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006595 ! cdc5l-myt1l physical interaction [Term] id: CCO:B0005602 name: LIPA2_HUMAN def: "Liprin-alpha-2" [UniProtKB:O75334] synonym: "Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2" EXACT [UniProtKB:O75334] synonym: "PTPRF-interacting protein alpha-2" EXACT [UniProtKB:O75334] xref: EMBL:AAC26100.1 xref: UniProtKB:O75334 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004982 ! PPFIA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006598 ! cdc5l-ppfia2 physical interaction relationship: transforms_into CCO:B0012702 ! LIPA2_HUMAN-Phosphoserine538 relationship: transforms_into CCO:B0012703 ! LIPA2_HUMAN-Phosphoserine689 relationship: transforms_into CCO:B0012704 ! LIPA2_HUMAN-Phosphoserine774 [Term] id: CCO:B0005603 name: TNIK_HUMAN def: "TRAF2 and NCK-interacting protein kinase" [UniProtKB:Q9UKE5] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9UKE5] xref: EMBL:AAF03782.1 xref: EMBL:AAF03783.1 xref: EMBL:AAF03784.1 xref: EMBL:AAF03785.1 xref: EMBL:AAF03786.1 xref: EMBL:AAF03787.1 xref: EMBL:AAF03788.1 xref: EMBL:AAF03789.1 xref: EMBL:AAH19081.2 xref: EMBL:BAA25477.2 xref: UniProtKB:O60298 xref: UniProtKB:Q8WUY7 xref: UniProtKB:Q9UKD8 xref: UniProtKB:Q9UKD9 xref: UniProtKB:Q9UKE0 xref: UniProtKB:Q9UKE1 xref: UniProtKB:Q9UKE2 xref: UniProtKB:Q9UKE3 xref: UniProtKB:Q9UKE4 xref: UniProtKB:Q9UKE5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005800 ! TNIK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006600 ! tnik-ppp1r13b physical interaction relationship: transforms_into CCO:B0014421 ! TNIK_HUMAN-Phosphoserine680 relationship: transforms_into CCO:B0014422 ! TNIK_HUMAN-Phosphoserine764 relationship: transforms_into CCO:B0014423 ! TNIK_HUMAN-Phosphoserine769 relationship: transforms_into CCO:B0014424 ! TNIK_HUMAN-Phosphothreonine987 relationship: transforms_into CCO:B0041218 ! TNIK_HUMAN-Phosphothreonine581 relationship: transforms_into CCO:B0041219 ! TNIK_HUMAN-Phosphoserine640 relationship: transforms_into CCO:B0041220 ! TNIK_HUMAN-Phosphothreonine677 [Term] id: CCO:B0005604 name: SPTB2_HUMAN def: "Spectrin beta chain, brain 1" [UniProtKB:Q01082] synonym: "Beta-II spectrin" EXACT [UniProtKB:Q01082] synonym: "Fodrin beta chain" EXACT [UniProtKB:Q01082] synonym: "Spectrin, non-erythroid beta chain 1" EXACT [UniProtKB:Q01082] xref: EMBL:AAA60580.1 xref: EMBL:AAB28324.1 xref: EMBL:AAO15362.1 xref: EMBL:AAY24229.1 xref: EMBL:BAD92985.1 xref: EMBL:CAA06678.1 xref: EMBL:CAB91088.1 xref: UniProtKB:O60837 xref: UniProtKB:Q01082 xref: UniProtKB:Q16057 xref: UniProtKB:Q53R99 xref: UniProtKB:Q59ER3 xref: UniProtKB:Q8IX99 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005667 ! SPTBN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006603 ! cdc5l-sptbn1 physical interaction relationship: participates_in CCO:I0008499 ! rint1-sptbn1 physical interaction relationship: transforms_into CCO:B0014190 ! SPTB2_HUMAN-Phosphothreonine999 relationship: transforms_into CCO:B0014191 ! SPTB2_HUMAN-Phosphoserine1918 relationship: transforms_into CCO:B0014192 ! SPTB2_HUMAN-Phosphoserine2102 relationship: transforms_into CCO:B0014193 ! SPTB2_HUMAN-Phosphoserine2115 relationship: transforms_into CCO:B0014194 ! SPTB2_HUMAN-Phosphoserine2128 relationship: transforms_into CCO:B0014195 ! SPTB2_HUMAN-Phosphoserine2138 relationship: transforms_into CCO:B0014196 ! SPTB2_HUMAN-Phosphoserine2165 relationship: transforms_into CCO:B0014197 ! SPTB2_HUMAN-Phosphoserine2169 relationship: transforms_into CCO:B0014198 ! SPTB2_HUMAN-Phosphothreonine2195 relationship: transforms_into CCO:B0031375 ! SPTB2_HUMAN-Phosphotyrosine1805 relationship: transforms_into CCO:B0041197 ! SPTB2_HUMAN-Phosphoserine2164 [Term] id: CCO:B0005605 name: CFTR_HUMAN def: "Cystic fibrosis transmembrane conductance regulator" [UniProtKB:P13569] synonym: "ATP-binding cassette transporter sub-family C member 7" EXACT [UniProtKB:P13569] synonym: "cAMP-dependent chloride channel" EXACT [UniProtKB:P13569] synonym: "CFTR" EXACT [UniProtKB:P13569] xref: EMBL:AAA35680.1 xref: EMBL:AAA51979.1 xref: EMBL:AAA51980.1 xref: EMBL:AAC13657.1 xref: EMBL:ABC79050.1 xref: EMBL:ABC79052.1 xref: EMBL:ABC79054.1 xref: EMBL:ABC79056.1 xref: EMBL:ABC87055.1 xref: EMBL:ABC87057.1 xref: EMBL:ABC87061.1 xref: EMBL:ABC87063.1 xref: EMBL:ABC87065.1 xref: EMBL:ABC87067.1 xref: EMBL:ABD72183.1 xref: EMBL:ABD72185.1 xref: EMBL:ABD72189.1 xref: EMBL:ABD72191.1 xref: EMBL:ABD72193.1 xref: EMBL:ABD72195.1 xref: EMBL:ABD72197.1 xref: EMBL:ABD72203.1 xref: EMBL:ABD72205.1 xref: EMBL:ABD72207.1 xref: EMBL:ABD72209.1 xref: EMBL:ABD72211.1 xref: EMBL:ABD72213.1 xref: EMBL:ABD72217.1 xref: EMBL:EAL24353.1 xref: UniProtKB:P13569 xref: UniProtKB:Q20BG8 xref: UniProtKB:Q20BH2 xref: UniProtKB:Q2I0A1 xref: UniProtKB:Q2I102 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004335 ! CFTR_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006606 ! cftr-ebp-1 physical interaction relationship: participates_in CCO:I0007478 ! cftr-ebp physical interaction relationship: participates_in CCO:I0007479 ! cftr-atp2a2 physical interaction relationship: participates_in CCO:I0007836 ! cftr-ebp-2 physical interaction relationship: transforms_into CCO:B0011183 ! CFTR_HUMAN-Phosphoserine660 relationship: transforms_into CCO:B0011184 ! CFTR_HUMAN-Phosphoserine686 relationship: transforms_into CCO:B0011185 ! CFTR_HUMAN-Phosphoserine700 relationship: transforms_into CCO:B0011186 ! CFTR_HUMAN-Phosphoserine712 relationship: transforms_into CCO:B0011187 ! CFTR_HUMAN-Phosphoserine737 relationship: transforms_into CCO:B0011188 ! CFTR_HUMAN-Phosphoserine753 relationship: transforms_into CCO:B0011189 ! CFTR_HUMAN-Phosphoserine768 relationship: transforms_into CCO:B0011190 ! CFTR_HUMAN-Phosphoserine790 relationship: transforms_into CCO:B0011191 ! CFTR_HUMAN-Phosphoserine795 relationship: transforms_into CCO:B0011192 ! CFTR_HUMAN-Phosphoserine813 [Term] id: CCO:B0005606 name: LIMK1_HUMAN def: "LIM domain kinase 1" [UniProtKB:P53667] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P53667] synonym: "LIMK-1" EXACT [UniProtKB:P53667] xref: EMBL:AAB17545.1 xref: EMBL:AAB17546.1 xref: EMBL:AAC13885.1 xref: EMBL:AAC13886.1 xref: EMBL:AAD25742.1 xref: EMBL:AAS07438.1 xref: EMBL:BAA05371.1 xref: UniProtKB:O15283 xref: UniProtKB:P53667 xref: UniProtKB:Q15820 xref: UniProtKB:Q15821 xref: UniProtKB:Q75MU3 xref: UniProtKB:Q9Y5Q1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004980 ! LIMK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006610 ! lats1-limk1-3 physical interaction relationship: participates_in CCO:I0006850 ! lats1-limk1-1 physical interaction relationship: participates_in CCO:I0006851 ! lats1-limk1-2 physical interaction relationship: participates_in CCO:I0007237 ! lats1-limk1-5 colocalization relationship: participates_in CCO:I0007730 ! lats1-limk1-4 physical interaction relationship: transforms_into CCO:B0012698 ! LIMK1_HUMAN-Phosphoserine298 relationship: transforms_into CCO:B0012699 ! LIMK1_HUMAN-Phosphoserine310 relationship: transforms_into CCO:B0012700 ! LIMK1_HUMAN-Phosphothreonine508 [Term] id: CCO:B0005607 name: MYT1_HUMAN def: "Myelin transcription factor 1" [UniProtKB:Q01538] synonym: "MyT1" EXACT [UniProtKB:Q01538] synonym: "MyTI" EXACT [UniProtKB:Q01538] synonym: "PLPB1" EXACT [UniProtKB:Q01538] synonym: "Proteolipid protein-binding protein" EXACT [UniProtKB:Q01538] xref: EMBL:AAA59897.1 xref: EMBL:BAA74858.2 xref: EMBL:BAA83002.1 xref: EMBL:CAC17005.1 xref: UniProtKB:O94922 xref: UniProtKB:Q01538 xref: UniProtKB:Q9UPV2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005153 ! MYT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006614 ! cdc2-myt1-1 phosphorylation [Term] id: CCO:B0005608 name: PTN6_HUMAN def: "Tyrosine-protein phosphatase non-receptor type 6" [UniProtKB:P29350] synonym: "EC 3.1.3.48" EXACT [UniProtKB:P29350] synonym: "Hematopoietic cell protein-tyrosine phosphatase" EXACT [UniProtKB:P29350] synonym: "Protein-tyrosine phosphatase 1C" EXACT [UniProtKB:P29350] synonym: "Protein-tyrosine phosphatase SHP-1" EXACT [UniProtKB:P29350] synonym: "PTP-1C" EXACT [UniProtKB:P29350] synonym: "SH-PTP1" EXACT [UniProtKB:P29350] xref: EMBL:AAA35963.1 xref: EMBL:AAA36610.1 xref: EMBL:AAA82879.1 xref: EMBL:AAA82880.1 xref: EMBL:AAB51322.1 xref: EMBL:AAB51323.1 xref: EMBL:AAH02523.1 xref: EMBL:AAH07667.1 xref: EMBL:BAC81774.1 xref: EMBL:BAC81775.1 xref: EMBL:CAA43982.1 xref: UniProtKB:P29350 xref: UniProtKB:Q969V8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005399 ! PTPN6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006615 ! khdrbs1-ptpn6-1 physical interaction relationship: transforms_into CCO:B0031369 ! PTN6_HUMAN-Phosphotyrosine377 relationship: transforms_into CCO:B0031370 ! PTN6_HUMAN-Phosphotyrosine536 relationship: transforms_into CCO:B0036024 ! PTN6_HUMAN-Phosphotyrosine509 [Term] id: CCO:B0005609 name: FYN_HUMAN def: "Proto-oncogene tyrosine-protein kinase Fyn" [UniProtKB:P06241] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P06241] synonym: "p59-Fyn" EXACT [UniProtKB:P06241] synonym: "Protooncogene Syn" EXACT [UniProtKB:P06241] synonym: "SLK" EXACT [UniProtKB:P06241] xref: EMBL:AAA36615.1 xref: EMBL:AAB33113.2 xref: EMBL:AAC08285.1 xref: EMBL:AAH32496.1 xref: EMBL:CAI22300.1 xref: EMBL:CAI22301.1 xref: UniProtKB:P06241 xref: UniProtKB:Q16248 xref: UniProtKB:Q5R3A6 xref: UniProtKB:Q5R3A7 xref: UniProtKB:Q8N5D7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004666 ! FYN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006616 ! khdrbs1-fyn-1 physical interaction relationship: participates_in CCO:I0007088 ! khdrbs1-fyn-2 physical interaction relationship: participates_in CCO:I0007089 ! khdrbs1-fyn-3 physical interaction relationship: transforms_into CCO:B0011907 ! FYN_HUMAN-Phosphothreonine12 relationship: transforms_into CCO:B0011908 ! FYN_HUMAN-Phosphoserine21 relationship: transforms_into CCO:B0011909 ! FYN_HUMAN-Phosphotyrosine420 relationship: transforms_into CCO:B0011910 ! FYN_HUMAN-Phosphotyrosine531 relationship: transforms_into CCO:B0031321 ! FYN_HUMAN-Phosphotyrosine185 [Term] id: CCO:B0005610 name: PLCG1_HUMAN def: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1" [UniProtKB:P19174] synonym: "EC 3.1.4.11" EXACT [UniProtKB:P19174] synonym: "Phosphoinositide phospholipase C" EXACT [UniProtKB:P19174] synonym: "Phospholipase C-gamma-1" EXACT [UniProtKB:P19174] synonym: "PLC-148" EXACT [UniProtKB:P19174] synonym: "PLC-gamma-1" EXACT [UniProtKB:P19174] synonym: "PLC-II" EXACT [UniProtKB:P19174] xref: EMBL:AAA36452.1 xref: EMBL:ABB84466.1 xref: EMBL:CAA18537.1 xref: UniProtKB:P19174 xref: UniProtKB:Q2V575 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005334 ! PLCG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006617 ! khdrbs1-plcg1-1 physical interaction relationship: transforms_into CCO:B0013564 ! PLCG1_HUMAN-Phosphotyrosine771 relationship: transforms_into CCO:B0013565 ! PLCG1_HUMAN-Phosphotyrosine775 relationship: transforms_into CCO:B0013566 ! PLCG1_HUMAN-Phosphotyrosine783 relationship: transforms_into CCO:B0013567 ! PLCG1_HUMAN-Phosphotyrosine1253 relationship: transforms_into CCO:B0031364 ! PLCG1_HUMAN-Phosphotyrosine379 relationship: transforms_into CCO:B0031365 ! PLCG1_HUMAN-Phosphotyrosine481 relationship: transforms_into CCO:B0031366 ! PLCG1_HUMAN-Phosphotyrosine506 relationship: transforms_into CCO:B0031367 ! PLCG1_HUMAN-Phosphotyrosine977 [Term] id: CCO:B0005611 name: CBL_HUMAN def: "E3 ubiquitin-protein ligase CBL" [UniProtKB:P22681] synonym: "Casitas B-lineage lymphoma proto-oncogene" EXACT [UniProtKB:P22681] synonym: "EC 6.3.2.-" EXACT [UniProtKB:P22681] synonym: "Proto-oncogene c-CBL" EXACT [UniProtKB:P22681] synonym: "RING finger protein 55" EXACT [UniProtKB:P22681] synonym: "Signal transduction protein CBL" EXACT [UniProtKB:P22681] xref: EMBL:CAA40393.1 xref: UniProtKB:P22681 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004228 ! CBL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006619 ! khdrbs1-cbl-1 physical interaction relationship: participates_in CCO:I0007122 ! egfr-cbl1-1 direct interaction relationship: participates_in CCO:I0007123 ! egfr-cbl1-4 direct interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0010944 ! CBL_HUMAN-Phosphotyrosine371 relationship: transforms_into CCO:B0010945 ! CBL_HUMAN-Phosphotyrosine552 relationship: transforms_into CCO:B0010946 ! CBL_HUMAN-Phosphoserine667 relationship: transforms_into CCO:B0010947 ! CBL_HUMAN-Phosphoserine669 relationship: transforms_into CCO:B0010948 ! CBL_HUMAN-Phosphotyrosine674 relationship: transforms_into CCO:B0010949 ! CBL_HUMAN-Phosphoserine675 relationship: transforms_into CCO:B0010950 ! CBL_HUMAN-Phosphotyrosine700 relationship: transforms_into CCO:B0010951 ! CBL_HUMAN-Phosphotyrosine774 relationship: transforms_into CCO:B0010952 ! CBL_HUMAN-Phosphoserine900 relationship: transforms_into CCO:B0031300 ! CBL_HUMAN-Phosphoserine668 [Term] id: CCO:B0005612 name: JAK3_HUMAN def: "Tyrosine-protein kinase JAK3" [UniProtKB:P52333] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P52333] synonym: "JAK-3" EXACT [UniProtKB:P52333] synonym: "Janus kinase 3" EXACT [UniProtKB:P52333] synonym: "L-JAK" EXACT [UniProtKB:P52333] synonym: "Leukocyte janus kinase" EXACT [UniProtKB:P52333] xref: EMBL:AAA19626.1 xref: EMBL:AAC50226.1 xref: EMBL:AAC50227.1 xref: EMBL:AAC50542.1 xref: EMBL:AAD22741.1 xref: EMBL:AAM44860.1 xref: UniProtKB:P52333 xref: UniProtKB:Q13259 xref: UniProtKB:Q13260 xref: UniProtKB:Q13611 xref: UniProtKB:Q9Y6S2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004909 ! JAK3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006620 ! khdrbs1-jak3-1 physical interaction relationship: participates_in CCO:I0006622 ! khdrbs1-jak3-2 physical interaction relationship: transforms_into CCO:B0012434 ! JAK3_HUMAN-Phosphothreonine8 relationship: transforms_into CCO:B0012435 ! JAK3_HUMAN-Phosphotyrosine785 relationship: transforms_into CCO:B0012436 ! JAK3_HUMAN-Phosphotyrosine980 [Term] id: CCO:B0005613 name: SET1A_HUMAN def: "Histone-lysine N-methyltransferase SETD1A" [UniProtKB:O15047] synonym: "EC 2.1.1.43" EXACT [UniProtKB:O15047] synonym: "hSET1A" EXACT [UniProtKB:O15047] synonym: "Lysine N-methyltransferase 2F" EXACT [UniProtKB:O15047] synonym: "SET domain-containing protein 1A" EXACT [UniProtKB:O15047] synonym: "Set1/Ash2 histone methyltransferase complex subunit SET1" EXACT [UniProtKB:O15047] xref: EMBL:AAH27450.1 xref: EMBL:AAH35795.1 xref: EMBL:BAA20797.2 xref: UniProtKB:A6NP62 xref: UniProtKB:O15047 xref: UniProtKB:Q6PIF3 xref: UniProtKB:Q8TAJ6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005596 ! SETD1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006624 ! hcfc1-set1-1 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: transforms_into CCO:B0014018 ! SET1A_HUMAN-Phosphoserine468 relationship: transforms_into CCO:B0014019 ! SET1A_HUMAN-Phosphoserine470 [Term] id: CCO:B0005614 name: ASH2L_HUMAN def: "Set1/Ash2 histone methyltransferase complex subunit ASH2" [UniProtKB:Q9UBL3] synonym: "ASH2-like protein" EXACT [UniProtKB:Q9UBL3] xref: EMBL:AAC13563.1 xref: EMBL:AAC13564.1 xref: EMBL:AAH15936.1 xref: EMBL:BAA35127.1 xref: EMBL:BAA74520.1 xref: UniProtKB:O60659 xref: UniProtKB:O60660 xref: UniProtKB:Q96B62 xref: UniProtKB:Q9UBL3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004107 ! ASH2L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006625 ! hcfc1-ash2l-1 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: participates_in CCO:I0007355 ! hcfc1-many-2 physical interaction relationship: participates_in CCO:I0007562 ! hcfc1-ash2l-2 physical interaction [Term] id: CCO:B0005615 name: WDR5_HUMAN def: "WD repeat-containing protein 5" [UniProtKB:P61964] synonym: "BMP2-induced 3-kb gene protein" EXACT [UniProtKB:P61964] xref: EMBL:AAH01635.1 xref: EMBL:BAA91248.1 xref: EMBL:CAB66159.1 xref: UniProtKB:P61964 xref: UniProtKB:Q91VA5 xref: UniProtKB:Q9NWX7 xref: UniProtKB:Q9UGP9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005923 ! WDR5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006626 ! hcfc1-wdr5-1 physical interaction relationship: participates_in CCO:I0006815 ! cul4a-cul4b-2 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: participates_in CCO:I0007717 ! cul4b-wdr5 physical interaction relationship: participates_in CCO:I0008534 ! wdr5-ddb1 physical interaction relationship: transforms_into CCO:B0014675 ! WDR5_HUMAN-Phosphoserine267 [Term] id: CCO:B0005616 name: PPARG_HUMAN def: "Peroxisome proliferator-activated receptor gamma" [UniProtKB:P37231] synonym: "Nuclear receptor subfamily 1 group C member 3" EXACT [UniProtKB:P37231] synonym: "PPAR-gamma" EXACT [UniProtKB:P37231] xref: EMBL:AAA80314.2 xref: EMBL:AAB04028.1 xref: EMBL:AAC51248.1 xref: EMBL:AAH06811.1 xref: EMBL:AAN38992.2 xref: EMBL:AAP35945.1 xref: EMBL:BAA18949.1 xref: EMBL:BAA23354.1 xref: EMBL:CAA62152.1 xref: EMBL:CAA62153.1 xref: UniProtKB:O00684 xref: UniProtKB:O00710 xref: UniProtKB:O14515 xref: UniProtKB:P37231 xref: UniProtKB:Q15178 xref: UniProtKB:Q15179 xref: UniProtKB:Q15180 xref: UniProtKB:Q15832 xref: UniProtKB:Q86U60 xref: UniProtKB:Q96J12 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005362 ! PPARG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006627 ! pparg-ep300 physical interaction relationship: transforms_into CCO:B0013599 ! PPARG_HUMAN-Phosphoserine112 [Term] id: CCO:B0005617 name: TCP10_HUMAN def: "T-complex protein 10A homolog" [UniProtKB:Q12799] xref: EMBL:AAA82109.1 xref: EMBL:CAI39675.1 xref: EMBL:CAI42705.1 xref: UniProtKB:Q12799 xref: UniProtKB:Q5JR60 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005749 ! TCP10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006631 ! pard6a-tcp10-2 physical interaction relationship: participates_in CCO:I0006633 ! pard6a-tcp10-3 physical interaction [Term] id: CCO:B0005619 name: UBQL4_HUMAN def: "Ubiquilin-4" [UniProtKB:Q9NRR5] synonym: "Ataxin-1 ubiquitin-like-interacting protein A1U" EXACT [UniProtKB:Q9NRR5] xref: EMBL:AAF19084.1 xref: EMBL:AAF80171.1 xref: EMBL:AAH06410.1 xref: EMBL:AAH18403.1 xref: EMBL:AAH63841.1 xref: UniProtKB:Q9BR98 xref: UniProtKB:Q9NRR5 xref: UniProtKB:Q9UHX4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005873 ! UBQLN4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006640 ! hrasls3-ubqln4 physical interaction relationship: participates_in CCO:I0006642 ! pin1-ubqln4 physical interaction relationship: participates_in CCO:I0007611 ! ubqln4-stmn1 physical interaction relationship: participates_in CCO:I0008206 ! ubqln4-smarcb1 physical interaction relationship: participates_in CCO:I0008363 ! ubqln4-appbp1 physical interaction relationship: transforms_into CCO:B0014571 ! UBQL4_HUMAN-Phosphoserine318 [Term] id: CCO:B0005621 name: P80C_HUMAN def: "Coilin" [UniProtKB:P38432] synonym: "p80" EXACT [UniProtKB:P38432] xref: EMBL:AAA36412.1 xref: EMBL:AAB81550.1 xref: EMBL:AAH10385.1 xref: UniProtKB:P38432 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005249 ! COIL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006649 ! mad1l1-coil physical interaction relationship: participates_in CCO:I0008761 ! psma1-coil physical interaction relationship: participates_in CCO:I0008762 ! psme3-coil physical interaction relationship: participates_in CCO:I0008765 ! coil-psme3-1 physical interaction relationship: participates_in CCO:I0008786 ! coil-psme3 physical interaction relationship: transforms_into CCO:B0013362 ! P80C_HUMAN-Phosphothreonine122 relationship: transforms_into CCO:B0013363 ! P80C_HUMAN-Phosphothreonine303 relationship: transforms_into CCO:B0013364 ! P80C_HUMAN-Phosphoserine489 [Term] id: CCO:B0005622 name: RPA12_HUMAN def: "DNA-directed RNA polymerase I subunit RPA12" [UniProtKB:Q9P1U0] synonym: "Zinc ribbon domain-containing protein 1" EXACT [UniProtKB:Q9P1U0] xref: EMBL:AAF40469.1 xref: EMBL:AAG50159.1 xref: EMBL:AAG50160.1 xref: EMBL:AAH10898.1 xref: EMBL:AAH50608.1 xref: EMBL:CAG33390.1 xref: EMBL:CAI17577.1 xref: EMBL:CAI18176.1 xref: EMBL:CAI18538.1 xref: EMBL:CAI95579.1 xref: UniProtKB:Q9P1U0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005524 ! ZNRD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006650 ! znrd1-gfi1b physical interaction [Term] id: CCO:B0005623 name: MEOX2_HUMAN def: "Homeobox protein MOX-2" [UniProtKB:P50222] synonym: "Growth arrest-specific homeobox" EXACT [UniProtKB:P50222] synonym: "Mesenchyme homeobox 2" EXACT [UniProtKB:P50222] xref: EMBL:AAA58497.1 xref: EMBL:AAC06184.1 xref: EMBL:AAC33152.1 xref: EMBL:AAH17021.1 xref: EMBL:CAA57949.1 xref: UniProtKB:O75263 xref: UniProtKB:P50222 xref: UniProtKB:Q9UPL6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005083 ! MEOX2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006654 ! meox2-hspa2 physical interaction [Term] id: CCO:B0005624 name: SCAM1_HUMAN def: "Secretory carrier-associated membrane protein 1" [UniProtKB:O15126] synonym: "Secretory carrier membrane protein 1" EXACT [UniProtKB:O15126] xref: EMBL:AAB62722.1 xref: EMBL:AAC39864.1 xref: EMBL:AAH09787.1 xref: EMBL:AAH15065.1 xref: EMBL:AAH34048.1 xref: UniProtKB:O15126 xref: UniProtKB:O43587 xref: UniProtKB:Q96BX1 xref: UniProtKB:Q96QK5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005570 ! SCAMP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006657 ! scamp1-tp53 physical interaction [Term] id: CCO:B0005625 name: DIPA_HUMAN def: "Delta-interacting protein A" [UniProtKB:Q15834] synonym: "Coiled-coil domain-containing protein 85B" EXACT [UniProtKB:Q15834] synonym: "Hepatitis delta antigen-interacting protein A" EXACT [UniProtKB:Q15834] xref: EMBL:AAB05928.1 xref: EMBL:AAH08796.1 xref: UniProtKB:Q15834 xref: UniProtKB:Q96HA0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004471 ! CCDC85B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006659 ! gfi1b-ccdc85b physical interaction [Term] id: CCO:B0005626 name: BEGIN_HUMAN def: "Brain-enriched guanylate kinase-associated protein" [UniProtKB:Q9BUH8] xref: EMBL:AAH02607.1 xref: EMBL:BAA95970.1 xref: EMBL:CAB99094.1 xref: UniProtKB:Q9BUH8 xref: UniProtKB:Q9NPU3 xref: UniProtKB:Q9P282 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004158 ! BEGAIN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006660 ! gfi1b-begain-1 physical interaction relationship: participates_in CCO:I0007654 ! gfi1b-begain physical interaction relationship: transforms_into CCO:B0010785 ! BEGIN_HUMAN-Phosphoserine194 relationship: transforms_into CCO:B0010786 ! BEGIN_HUMAN-Phosphoserine246 relationship: transforms_into CCO:B0010787 ! BEGIN_HUMAN-Phosphoserine265 relationship: transforms_into CCO:B0010788 ! BEGIN_HUMAN-Phosphoserine465 relationship: transforms_into CCO:B0010789 ! BEGIN_HUMAN-Phosphoserine483 relationship: transforms_into CCO:B0010790 ! BEGIN_HUMAN-Phosphoserine502 relationship: transforms_into CCO:B0010791 ! BEGIN_HUMAN-Phosphoserine563 relationship: transforms_into CCO:B0031299 ! BEGIN_HUMAN-Phosphotyrosine137 [Term] id: CCO:B0005627 name: K1279_HUMAN def: "Uncharacterized protein KIAA1279" [UniProtKB:Q96EK5] xref: EMBL:AAH12180.1 xref: EMBL:BAA86593.1 xref: EMBL:CAB43311.1 xref: EMBL:CAH72378.1 xref: UniProtKB:Q96EK5 xref: UniProtKB:Q9BR89 xref: UniProtKB:Q9ULE1 xref: UniProtKB:Q9Y428 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004917 ! KIAA1279_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006662 ! hbp1-kiaa1279 physical interaction [Term] id: CCO:B0005628 name: ALK_HUMAN def: "ALK tyrosine kinase receptor precursor" [UniProtKB:Q9UM73] synonym: "Anaplastic lymphoma kinase" EXACT [UniProtKB:Q9UM73] synonym: "CD246 antigen" EXACT [UniProtKB:Q9UM73] synonym: "EC 2.7.10.1" EXACT [UniProtKB:Q9UM73] xref: EMBL:AAB71619.1 xref: EMBL:AAC51104.1 xref: EMBL:AAX88892.1 xref: EMBL:AAX93126.1 xref: EMBL:AAY15027.1 xref: EMBL:BAD92714.1 xref: UniProtKB:Q4ZFX9 xref: UniProtKB:Q53QQ6 xref: UniProtKB:Q53RZ4 xref: UniProtKB:Q59FI3 xref: UniProtKB:Q9UM73 xref: UniProtKB:Q9Y4K6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004049 ! ALK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006664 ! npm_alk-gak physical interaction relationship: participates_in CCO:I0006665 ! npm_alk-cdc14 physical interaction relationship: transforms_into CCO:B0010499 ! ALK_HUMAN-Phosphoserine211 relationship: transforms_into CCO:B0010500 ! ALK_HUMAN-Phosphotyrosine1078 relationship: transforms_into CCO:B0010501 ! ALK_HUMAN-Phosphotyrosine1092 relationship: transforms_into CCO:B0010502 ! ALK_HUMAN-Phosphotyrosine1096 relationship: transforms_into CCO:B0010503 ! ALK_HUMAN-Phosphotyrosine1131 relationship: transforms_into CCO:B0010504 ! ALK_HUMAN-Phosphotyrosine1278 relationship: transforms_into CCO:B0010505 ! ALK_HUMAN-Phosphotyrosine1282 relationship: transforms_into CCO:B0010506 ! ALK_HUMAN-Phosphotyrosine1507 relationship: transforms_into CCO:B0010507 ! ALK_HUMAN-Phosphotyrosine1584 relationship: transforms_into CCO:B0010508 ! ALK_HUMAN-Phosphotyrosine1604 [Term] id: CCO:B0005629 name: KS6A4_HUMAN def: "Ribosomal protein S6 kinase alpha-4" [UniProtKB:O75676] synonym: "90 kDa ribosomal protein S6 kinase 4" EXACT [UniProtKB:O75676] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O75676] synonym: "Nuclear mitogen- and stress-activated protein kinase 2" EXACT [UniProtKB:O75676] synonym: "Ribosomal protein kinase B" EXACT [UniProtKB:O75676] synonym: "RSKB" EXACT [UniProtKB:O75676] xref: EMBL:AAC67395.1 xref: EMBL:BAD97281.1 xref: EMBL:CAA09009.1 xref: UniProtKB:O75585 xref: UniProtKB:O75676 xref: UniProtKB:Q53ES8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004961 ! RPS6KA4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006672 ! rps6ka4-mapk3 physical interaction relationship: transforms_into CCO:B0012637 ! KS6A4_HUMAN-Phosphoserine196 relationship: transforms_into CCO:B0012638 ! KS6A4_HUMAN-Phosphoserine343 relationship: transforms_into CCO:B0012639 ! KS6A4_HUMAN-Phosphoserine347 relationship: transforms_into CCO:B0012640 ! KS6A4_HUMAN-Phosphoserine360 relationship: transforms_into CCO:B0012641 ! KS6A4_HUMAN-Phosphothreonine568 relationship: transforms_into CCO:B0012642 ! KS6A4_HUMAN-Phosphoserine681 relationship: transforms_into CCO:B0012643 ! KS6A4_HUMAN-Phosphoserine682 relationship: transforms_into CCO:B0012644 ! KS6A4_HUMAN-Phosphoserine737 [Term] id: CCO:B0005630 name: ANM2_HUMAN def: "Protein arginine N-methyltransferase 2" [UniProtKB:P55345] synonym: "EC 2.1.1.-" EXACT [UniProtKB:P55345] xref: EMBL:AAB48437.1 xref: EMBL:AAH00727.1 xref: EMBL:CAA67599.1 xref: EMBL:CAB52454.1 xref: UniProtKB:P55345 xref: UniProtKB:P78350 xref: UniProtKB:Q9BW15 xref: UniProtKB:Q9UMC2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004064 ! PRMT2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006673 ! hrmt1l1-rara-1 physical interaction [Term] id: CCO:B0005633 name: FBW1A_HUMAN def: "F-box/WD repeat-containing protein 1A" [UniProtKB:Q9Y297] synonym: "E3RSIkappaB" EXACT [UniProtKB:Q9Y297] synonym: "F-box and WD repeats protein beta-TrCP" EXACT [UniProtKB:Q9Y297] synonym: "pIkappaBalpha-E3 receptor subunit" EXACT [UniProtKB:Q9Y297] xref: EMBL:AAD08702.1 xref: EMBL:AAF04464.1 xref: EMBL:AAH27994.1 xref: EMBL:CAA74572.1 xref: UniProtKB:Q9Y213 xref: UniProtKB:Q9Y297 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004619 ! BTRC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006693 ! cul1-tip120a-3 physical interaction relationship: participates_in CCO:I0006696 ! cul1-skp1-2 physical interaction relationship: participates_in CCO:I0007600 ! btrc-skp1-1 physical interaction relationship: participates_in CCO:I0007601 ! btrc-wee1 physical interaction relationship: participates_in CCO:I0008695 ! btrc-trim9 physical interaction relationship: participates_in CCO:I0008720 ! btrc-ctnnb1-1 physical interaction relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0005634 name: SKP1_HUMAN def: "S-phase kinase-associated protein 1" [UniProtKB:P63208] synonym: "Cyclin A/CDK2-associated protein p19" EXACT [UniProtKB:P63208] synonym: "OCP-2" EXACT [UniProtKB:P63208] synonym: "OCP-II" EXACT [UniProtKB:P63208] synonym: "Organ of Corti protein 2" EXACT [UniProtKB:P63208] synonym: "p19A" EXACT [UniProtKB:P63208] synonym: "p19skp1" EXACT [UniProtKB:P63208] synonym: "RNA polymerase II elongation factor-like protein" EXACT [UniProtKB:P63208] synonym: "S-phase kinase-associated protein 1" EXACT [UniProtKB:P63208] synonym: "SIII" EXACT [UniProtKB:P63208] synonym: "Transcription elongation factor B" EXACT [UniProtKB:P63208] xref: EMBL:AAA79202.1 xref: EMBL:AAC50241.1 xref: EMBL:AAH09839.1 xref: EMBL:AAH20798.1 xref: EMBL:AAH25673.1 xref: EMBL:AAH65730.1 xref: EMBL:CAA87392.1 xref: UniProtKB:P34991 xref: UniProtKB:P63208 xref: UniProtKB:Q8TAY2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0010899 ! SKP1_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:I0006242 ! fbxo25-cul1-1 physical interaction relationship: participates_in CCO:I0006243 ! fbxo4-cul1-2 physical interaction relationship: participates_in CCO:I0006244 ! fbxo7-cul1-1 physical interaction relationship: participates_in CCO:I0006693 ! cul1-tip120a-3 physical interaction relationship: participates_in CCO:I0006695 ! cul1-skp1-1 physical interaction relationship: participates_in CCO:I0006696 ! cul1-skp1-2 physical interaction relationship: participates_in CCO:I0006697 ! cul1-skp1-3 physical interaction relationship: participates_in CCO:I0006767 ! skp1a-skp2-1 direct interaction relationship: participates_in CCO:I0006768 ! skp1a-skp2-2 direct interaction relationship: participates_in CCO:I0006769 ! skp1a-skp2-3 direct interaction relationship: participates_in CCO:I0006797 ! cul1-cul1-7 physical interaction relationship: participates_in CCO:I0007106 ! cul1-cand1-1 physical interaction relationship: participates_in CCO:I0007598 ! skp2-skp1 physical interaction relationship: participates_in CCO:I0007599 ! fbxw11-skp1 physical interaction relationship: participates_in CCO:I0007600 ! btrc-skp1-1 physical interaction relationship: participates_in CCO:I0007733 ! skp2-cks1-4 physical interaction relationship: participates_in CCO:I0007943 ! fbxo11-skp1-1 physical interaction relationship: participates_in CCO:I0008720 ! btrc-ctnnb1-1 physical interaction relationship: participates_in CCO:I0008774 ! fbxl7-skp1 physical interaction relationship: participates_in CCO:I0008775 ! fbxl2-skp1 physical interaction relationship: participates_in CCO:I0008776 ! fbw5-skp1 physical interaction relationship: participates_in CCO:I0008777 ! fbw6-skp1 physical interaction relationship: participates_in CCO:I0008778 ! fbw7-skp1 physical interaction relationship: participates_in CCO:I0008779 ! fbxo41-skp1 physical interaction relationship: participates_in CCO:I0008780 ! fbox11-skp1 physical interaction relationship: participates_in CCO:I0008805 ! fbxo34-skp1a physical interaction relationship: participates_in CCO:I0008806 ! skp1a-fbxo34 physical interaction relationship: participates_in CCO:I0008820 ! ddx19b-skp1a physical interaction relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0005636 name: RAF1_HUMAN def: "RAF proto-oncogene serine/threonine-protein kinase" [UniProtKB:P04049] synonym: "C-RAF" EXACT [UniProtKB:P04049] synonym: "cRaf" EXACT [UniProtKB:P04049] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P04049] synonym: "Raf-1" EXACT [UniProtKB:P04049] xref: EMBL:AAH18119.1 xref: EMBL:AAP03432.1 xref: EMBL:CAA27204.1 xref: UniProtKB:P04049 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005421 ! RAF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006916 ! raf1-rap1a-1 direct interaction relationship: participates_in CCO:I0007163 ! raf1-rap1a-2 direct interaction relationship: participates_in CCO:I0007860 ! raf1-pbk physical interaction relationship: transforms_into CCO:B0013679 ! RAF1_HUMAN-Phosphoserine43 relationship: transforms_into CCO:B0013680 ! RAF1_HUMAN-Phosphoserine252 relationship: transforms_into CCO:B0013681 ! RAF1_HUMAN-Phosphoserine259 relationship: transforms_into CCO:B0013682 ! RAF1_HUMAN-Phosphothreonine268 relationship: transforms_into CCO:B0013683 ! RAF1_HUMAN-Phosphoserine294 relationship: transforms_into CCO:B0013684 ! RAF1_HUMAN-Phosphoserine301 relationship: transforms_into CCO:B0013685 ! RAF1_HUMAN-Phosphoserine338 relationship: transforms_into CCO:B0013686 ! RAF1_HUMAN-Phosphoserine499 relationship: transforms_into CCO:B0013687 ! RAF1_HUMAN-Phosphoserine621 [Term] id: CCO:B0005637 name: ELK1_HUMAN def: "ETS domain-containing protein Elk-1" [UniProtKB:P19419] xref: EMBL:AAA52384.1 xref: EMBL:AAC82466.1 xref: EMBL:AAD00862.1 xref: EMBL:AAH56150.1 xref: EMBL:BAA36616.1 xref: EMBL:BAA36617.1 xref: EMBL:CAA15659.1 xref: UniProtKB:O75606 xref: UniProtKB:O95058 xref: UniProtKB:P19419 xref: UniProtKB:Q969X8 xref: UniProtKB:Q9UJM4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004559 ! ELK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006717 ! mapk3-elk1-1 phosphorylation relationship: participates_in CCO:I0006718 ! mapk1-elk1-1 phosphorylation relationship: transforms_into CCO:B0011674 ! ELK1_HUMAN-Phosphoserine324 relationship: transforms_into CCO:B0011675 ! ELK1_HUMAN-Phosphothreonine336 relationship: transforms_into CCO:B0011676 ! ELK1_HUMAN-Phosphoserine383 relationship: transforms_into CCO:B0011677 ! ELK1_HUMAN-Phosphoserine389 relationship: transforms_into CCO:B0011678 ! ELK1_HUMAN-Phosphoserine422 [Term] id: CCO:B0005639 name: MSH6_HUMAN def: "DNA mismatch repair protein Msh6" [UniProtKB:P52701] synonym: "G/T mismatch-binding protein" EXACT [UniProtKB:P52701] synonym: "GTBP" EXACT [UniProtKB:P52701] synonym: "GTMBP" EXACT [UniProtKB:P52701] synonym: "MutS-alpha 160 kDa subunit" EXACT [UniProtKB:P52701] synonym: "p160" EXACT [UniProtKB:P52701] xref: EMBL:AAB39212.2 xref: EMBL:AAB47425.1 xref: EMBL:AAC50461.1 xref: EMBL:AAH04246.1 xref: EMBL:AAL87401.1 xref: EMBL:BAA23674.1 xref: EMBL:BAA23675.1 xref: UniProtKB:O43706 xref: UniProtKB:O43917 xref: UniProtKB:P52701 xref: UniProtKB:Q8TCX4 xref: UniProtKB:Q9BTB5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005130 ! MSH6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006720 ! msh2-msh6-1 physical interaction relationship: participates_in CCO:I0006887 ! brca1-trrap-6 physical interaction relationship: participates_in CCO:I0007030 ! msh2-msh6 physical interaction relationship: participates_in CCO:I0007031 ! msh6-msh2 physical interaction relationship: participates_in CCO:I0007034 ! msh6-msh2-1 physical interaction relationship: participates_in CCO:I0007455 ! brca1-trrap-1 physical interaction relationship: participates_in CCO:I0007838 ! msh2-msh6-2 physical interaction relationship: transforms_into CCO:B0013016 ! MSH6_HUMAN-Phosphoserine14 relationship: transforms_into CCO:B0013017 ! MSH6_HUMAN-Phosphoserine41 relationship: transforms_into CCO:B0013018 ! MSH6_HUMAN-Phosphoserine43 relationship: transforms_into CCO:B0013019 ! MSH6_HUMAN-Phosphoserine137 relationship: transforms_into CCO:B0013020 ! MSH6_HUMAN-Phosphothreonine139 relationship: transforms_into CCO:B0013021 ! MSH6_HUMAN-Phosphoserine219 relationship: transforms_into CCO:B0013022 ! MSH6_HUMAN-Phosphoserine227 relationship: transforms_into CCO:B0013023 ! MSH6_HUMAN-Phosphoserine252 relationship: transforms_into CCO:B0013024 ! MSH6_HUMAN-Phosphoserine254 relationship: transforms_into CCO:B0013025 ! MSH6_HUMAN-Phosphoserine256 relationship: transforms_into CCO:B0013026 ! MSH6_HUMAN-Phosphoserine261 relationship: transforms_into CCO:B0013027 ! MSH6_HUMAN-Phosphoserine348 relationship: transforms_into CCO:B0013028 ! MSH6_HUMAN-Phosphoserine830 relationship: transforms_into CCO:B0013029 ! MSH6_HUMAN-Phosphothreonine924 [Term] id: CCO:B0005640 name: AP2A_HUMAN def: "Transcription factor AP-2 alpha" [UniProtKB:P05549] synonym: "Activating enhancer-binding protein 2 alpha" EXACT [UniProtKB:P05549] synonym: "Activator protein 2" EXACT [UniProtKB:P05549] synonym: "AP-2" EXACT [UniProtKB:P05549] synonym: "AP-2 transcription factor" EXACT [UniProtKB:P05549] synonym: "AP2-alpha" EXACT [UniProtKB:P05549] xref: EMBL:AAA02487.1 xref: EMBL:AAA35539.1 xref: EMBL:CAA36842.1 xref: EMBL:CAB59735.1 xref: UniProtKB:P05549 xref: UniProtKB:Q13777 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004072 ! TFAP2A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006721 ! p300-tfap2a-7 physical interaction relationship: participates_in CCO:I0006724 ! p300-tfap2a-2 physical interaction relationship: participates_in CCO:I0006725 ! p300-tfap2a-3 physical interaction relationship: participates_in CCO:I0006726 ! p300-tfap2a-4 physical interaction relationship: participates_in CCO:I0006727 ! p300-tfap2a-5 physical interaction relationship: participates_in CCO:I0006891 ! cited2-tfap2a-1 physical interaction relationship: participates_in CCO:I0007146 ! p300-tfap2a-1 physical interaction relationship: participates_in CCO:I0007417 ! p300-tfap2a-6 physical interaction relationship: participates_in CCO:I0007918 ! ap2a-ubc9-1 physical interaction relationship: participates_in CCO:I0007921 ! ubc9-ap2a-1 physical interaction relationship: transforms_into CCO:B0010563 ! AP2A_HUMAN-Phosphoserine239 [Term] id: CCO:B0005641 name: SRBS1_HUMAN def: "Sorbin and SH3 domain-containing protein 1" [UniProtKB:Q9BX66] synonym: "c-Cbl-associated protein" EXACT [UniProtKB:Q9BX66] synonym: "CAP" EXACT [UniProtKB:Q9BX66] synonym: "Ponsin" EXACT [UniProtKB:Q9BX66] synonym: "SH3 domain protein 5" EXACT [UniProtKB:Q9BX66] synonym: "SH3P12" EXACT [UniProtKB:Q9BX66] xref: EMBL:AAB93496.1 xref: EMBL:AAD27647.1 xref: EMBL:AAF22175.1 xref: EMBL:AAH42612.1 xref: EMBL:AAK37563.1 xref: EMBL:AAK37564.1 xref: EMBL:AAK37565.1 xref: EMBL:AAK57479.1 xref: EMBL:AAK57480.1 xref: EMBL:BAA92534.1 xref: EMBL:CAB55947.1 xref: EMBL:CAD34588.1 xref: UniProtKB:O43857 xref: UniProtKB:Q7LBE5 xref: UniProtKB:Q8IVK0 xref: UniProtKB:Q8IVQ4 xref: UniProtKB:Q96KF3 xref: UniProtKB:Q96KF4 xref: UniProtKB:Q9BX64 xref: UniProtKB:Q9BX65 xref: UniProtKB:Q9BX66 xref: UniProtKB:Q9P2Q0 xref: UniProtKB:Q9UFT2 xref: UniProtKB:Q9UHN7 xref: UniProtKB:Q9Y338 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005669 ! SORBS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006728 ! abl1-sorbs-2 physical interaction relationship: participates_in CCO:I0007751 ! abl1-sorbs-1 physical interaction relationship: transforms_into CCO:B0014201 ! SRBS1_HUMAN-Phosphoserine89 relationship: transforms_into CCO:B0014202 ! SRBS1_HUMAN-Phosphotyrosine134 relationship: transforms_into CCO:B0014203 ! SRBS1_HUMAN-Phosphothreonine349 relationship: transforms_into CCO:B0014204 ! SRBS1_HUMAN-Phosphoserine481 relationship: transforms_into CCO:B0014205 ! SRBS1_HUMAN-Phosphothreonine497 relationship: transforms_into CCO:B0014206 ! SRBS1_HUMAN-Phosphoserine556 relationship: transforms_into CCO:B0014207 ! SRBS1_HUMAN-Phosphoserine640 [Term] id: CCO:B0005642 name: ACTN2_HUMAN def: "Alpha-actinin-2" [UniProtKB:P35609] synonym: "Alpha-actinin skeletal muscle isoform 2" EXACT [UniProtKB:P35609] synonym: "F-actin cross-linking protein" EXACT [UniProtKB:P35609] xref: EMBL:AAA51583.1 xref: EMBL:AAA51584.1 xref: EMBL:AAH47901.2 xref: EMBL:AAH51770.2 xref: EMBL:CAB61269.1 xref: UniProtKB:P35609 xref: UniProtKB:Q86TF4 xref: UniProtKB:Q86TI8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004022 ! ACTN2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006732 ! actn2-ttn-4 physical interaction relationship: participates_in CCO:I0006874 ! ttn-actn2-5 physical interaction relationship: participates_in CCO:I0007124 ! actn2-ttn-3 physical interaction relationship: participates_in CCO:I0007125 ! actn2-ttn-6 physical interaction relationship: participates_in CCO:I0007571 ! ttn-actn2-1 physical interaction relationship: participates_in CCO:I0007758 ! actn2-ttn-2 physical interaction [Term] id: CCO:B0005643 name: O43397_HUMAN def: "Tumor protein D53" [UniProtKB:O43397] xref: EMBL:AAC98475.1 xref: UniProtKB:O43397 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005817 ! TPD52L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006740 ! hd53-hd53-3 physical interaction [Term] id: CCO:B0005644 name: Q9BWP7_HUMAN def: "Promyelocytic leukemia" [UniProtKB:Q9BWP7] xref: EMBL:AAH00080.2 xref: EMBL:AAH20994.1 xref: EMBL:AAP88913.1 xref: UniProtKB:Q8WUA0 xref: UniProtKB:Q9BWP7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005344 ! PML_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006742 ! pml-suv39h1-2 physical interaction [Term] id: CCO:B0005645 name: OBSCN_HUMAN def: "Obscurin" [UniProtKB:Q5VST9] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q5VST9] synonym: "Obscurin-MLCK" EXACT [UniProtKB:Q5VST9] synonym: "Obscurin-myosin light chain kinase" EXACT [UniProtKB:Q5VST9] synonym: "Obscurin-RhoGEF" EXACT [UniProtKB:Q5VST9] xref: EMBL:AAH43916.1 xref: EMBL:BAB13382.1 xref: EMBL:BAB13465.2 xref: EMBL:CAC44768.1 xref: EMBL:CAC85745.1 xref: EMBL:CAC85746.1 xref: EMBL:CAC85747.1 xref: EMBL:CAC85749.1 xref: EMBL:CAC85750.1 xref: EMBL:CAC85751.1 xref: EMBL:CAC85752.1 xref: EMBL:CAC85753.1 xref: EMBL:CAC85754.1 xref: EMBL:CAC85755.1 xref: EMBL:CAH71670.2 xref: EMBL:CAH71673.1 xref: EMBL:CAI15072.1 xref: EMBL:CAI19283.1 xref: EMBL:CAI19284.1 xref: EMBL:CAI19285.1 xref: EMBL:CAJ76912.1 xref: UniProtKB:Q2A664 xref: UniProtKB:Q5T7G8 xref: UniProtKB:Q5T7G9 xref: UniProtKB:Q5VST9 xref: UniProtKB:Q5VSU2 xref: UniProtKB:Q86YC7 xref: UniProtKB:Q8NHN0 xref: UniProtKB:Q8NHN1 xref: UniProtKB:Q8NHN2 xref: UniProtKB:Q8NHN3 xref: UniProtKB:Q8NHN4 xref: UniProtKB:Q8NHN5 xref: UniProtKB:Q8NHN6 xref: UniProtKB:Q8NHN7 xref: UniProtKB:Q8NHN8 xref: UniProtKB:Q8NHN9 xref: UniProtKB:Q96AA2 xref: UniProtKB:Q9HCD3 xref: UniProtKB:Q9HCL6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005228 ! OBSCN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006743 ! ttn-obscn-3 physical interaction relationship: participates_in CCO:I0007004 ! ttn-obscn-1 physical interaction relationship: participates_in CCO:I0007452 ! ttn-obscn-2 physical interaction [Term] id: CCO:B0005647 name: GCNL2_HUMAN def: "General control of amino acid synthesis protein 5-like 2" [UniProtKB:Q92830] synonym: "EC 2.3.1.48" EXACT [UniProtKB:Q92830] synonym: "Histone acetyltransferase GCN5" EXACT [UniProtKB:Q92830] synonym: "hsGCN5" EXACT [UniProtKB:Q92830] synonym: "STAF97" EXACT [UniProtKB:Q92830] xref: EMBL:AAC39769.1 xref: EMBL:AAC50641.1 xref: UniProtKB:Q92830 xref: UniProtKB:Q9UCW1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004690 ! GCN5L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006748 ! brca1-trrap-2 physical interaction relationship: participates_in CCO:I0006749 ! brca1-trrap-3 physical interaction relationship: participates_in CCO:I0006887 ! brca1-trrap-6 physical interaction relationship: participates_in CCO:I0007454 ! brca1-trrap physical interaction relationship: participates_in CCO:I0007455 ! brca1-trrap-1 physical interaction relationship: participates_in CCO:I0007595 ! brca1-trrap-5 physical interaction relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction relationship: transforms_into CCO:B0011925 ! GCNL2_HUMAN-Phosphotyrosine734 [Term] id: CCO:B0005648 name: DC1I1_HUMAN def: "Cytoplasmic dynein 1 intermediate chain 1" [UniProtKB:O14576] synonym: "Cytoplasmic dynein intermediate chain 1" EXACT [UniProtKB:O14576] synonym: "DH IC-1" EXACT [UniProtKB:O14576] synonym: "Dynein intermediate chain 1, cytosolic" EXACT [UniProtKB:O14576] xref: EMBL:AAB67047.2 xref: EMBL:AAB70113.1 xref: EMBL:AAC33443.1 xref: EMBL:AAD26852.1 xref: EMBL:BAC03639.1 xref: UniProtKB:O14576 xref: UniProtKB:Q9Y2X1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004442 ! DYNC1I1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006754 ! zw10_dync1l1_1 colocalization relationship: transforms_into CCO:B0011441 ! DC1I1_HUMAN-Phosphoserine635 [Term] id: CCO:B0005649 name: PPM1A_HUMAN def: "Protein phosphatase 1A" [UniProtKB:P35813] synonym: "EC 3.1.3.16" EXACT [UniProtKB:P35813] synonym: "IA" EXACT [UniProtKB:P35813] synonym: "PP2C-alpha" EXACT [UniProtKB:P35813] synonym: "Protein phosphatase 2C isoform alpha" EXACT [UniProtKB:P35813] xref: EMBL:AAB21784.1 xref: EMBL:AAC28354.1 xref: EMBL:AAH26691.1 xref: EMBL:AAH63243.1 xref: UniProtKB:O75551 xref: UniProtKB:P35813 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005366 ! PPM1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006759 ! sgol1-ppm1a-1 physical interaction relationship: participates_in CCO:I0006762 ! sgol2-ppm1a-1 physical interaction relationship: transforms_into CCO:B0013604 ! PPM1A_HUMAN-Phosphoserine377 [Term] id: CCO:B0005650 name: SHOC2_HUMAN def: "Leucine-rich repeat protein SHOC-2" [UniProtKB:Q9UQ13] synonym: "Ras-binding protein Sur-8" EXACT [UniProtKB:Q9UQ13] xref: EMBL:AAC25698.1 xref: EMBL:AAC39856.1 xref: EMBL:AAH50445.1 xref: EMBL:BAA74885.2 xref: UniProtKB:O76063 xref: UniProtKB:Q9UQ13 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005611 ! SHOC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006766 ! shoc2-erbb2ip-2 physical interaction relationship: participates_in CCO:I0007382 ! shoc2-erbb2ip physical interaction relationship: participates_in CCO:I0007383 ! shoc2-erbb2ip-3 physical interaction relationship: participates_in CCO:I0007466 ! shoc2-erbb2ip-1 physical interaction [Term] id: CCO:B0005651 name: XRCC4_HUMAN def: "DNA-repair protein XRCC4" [UniProtKB:Q13426] synonym: "X-ray repair cross-complementing protein 4" EXACT [UniProtKB:Q13426] xref: EMBL:AAC50339.1 xref: EMBL:AAD47297.1 xref: EMBL:AAD47298.1 xref: EMBL:AAH05259.1 xref: EMBL:AAH16314.1 xref: EMBL:AAP35880.1 xref: EMBL:AAX14046.1 xref: EMBL:BAB20668.1 xref: UniProtKB:Q13426 xref: UniProtKB:Q9BS72 xref: UniProtKB:Q9UP94 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005946 ! XRCC4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006771 ! lig4-xrcc4-1 direct interaction relationship: transforms_into CCO:B0014719 ! XRCC4_HUMAN-Phosphoserine260 relationship: transforms_into CCO:B0014720 ! XRCC4_HUMAN-Phosphoserine320 [Term] id: CCO:B0005652 name: ESR1_HUMAN def: "Estrogen receptor" [UniProtKB:P03372] synonym: "ER" EXACT [UniProtKB:P03372] synonym: "ER-alpha" EXACT [UniProtKB:P03372] synonym: "Estradiol receptor" EXACT [UniProtKB:P03372] synonym: "Nuclear receptor subfamily 3 group A member 1" EXACT [UniProtKB:P03372] xref: EMBL:AAA52399.1 xref: EMBL:AAB00115.1 xref: EMBL:AAD52984.1 xref: EMBL:AAQ91815.1 xref: EMBL:CAA27284.1 xref: EMBL:CAA51528.1 xref: EMBL:CAA99436.1 xref: EMBL:CAI42285.1 xref: UniProtKB:P03372 xref: UniProtKB:Q13511 xref: UniProtKB:Q14276 xref: UniProtKB:Q9NU51 xref: UniProtKB:Q9UDZ7 xref: UniProtKB:Q9UIS7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004590 ! ESR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006772 ! brca1-esr1 physical interaction relationship: participates_in CCO:I0006773 ! esr1-brca1-10 physical interaction relationship: participates_in CCO:I0006774 ! brca1-esr1-2 physical interaction relationship: participates_in CCO:I0006775 ! esr1-brca1-11 physical interaction relationship: participates_in CCO:I0006914 ! esr1-brca1-5 direct interaction relationship: participates_in CCO:I0006915 ! esr1-brca1-7 direct interaction relationship: participates_in CCO:I0007017 ! brca1-esr1-4 direct interaction relationship: participates_in CCO:I0007018 ! brca1-esr1-5 direct interaction relationship: participates_in CCO:I0007492 ! esr1-brca1-1 direct interaction relationship: participates_in CCO:I0007493 ! esr1-brca1-2 direct interaction relationship: participates_in CCO:I0007494 ! esr1-brca1-3 direct interaction relationship: participates_in CCO:I0007495 ! esr1-brca1-6 direct interaction relationship: transforms_into CCO:B0011768 ! ESR1_HUMAN-Phosphoserine104 relationship: transforms_into CCO:B0011769 ! ESR1_HUMAN-Phosphoserine106 relationship: transforms_into CCO:B0011770 ! ESR1_HUMAN-Phosphoserine118 relationship: transforms_into CCO:B0011771 ! ESR1_HUMAN-Phosphoserine167 relationship: transforms_into CCO:B0011772 ! ESR1_HUMAN-Phosphotyrosine537 relationship: transforms_into CCO:B0036003 ! ESR1_HUMAN-Phosphothreonine7 relationship: transforms_into CCO:B0036004 ! ESR1_HUMAN-Phosphoserine10 [Term] id: CCO:B0005653 name: RANG_HUMAN def: "Ran-specific GTPase-activating protein" [UniProtKB:P43487] synonym: "Ran-binding protein 1" EXACT [UniProtKB:P43487] synonym: "RanBP1" EXACT [UniProtKB:P43487] xref: EMBL:BAA07269.1 xref: EMBL:CAA58592.1 xref: EMBL:CAG30442.1 xref: UniProtKB:P43487 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005424 ! RANBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006776 ! ran-ranbp1-1 physical interaction relationship: participates_in CCO:I0006777 ! ran-ranbp1-2 physical interaction relationship: transforms_into CCO:B0013701 ! RANG_HUMAN-Phosphothreonine13 relationship: transforms_into CCO:B0013702 ! RANG_HUMAN-Phosphoserine14 relationship: transforms_into CCO:B0013703 ! RANG_HUMAN-Phosphothreonine15 relationship: transforms_into CCO:B0013704 ! RANG_HUMAN-Phosphothreonine18 relationship: transforms_into CCO:B0013705 ! RANG_HUMAN-Phosphoserine21 relationship: transforms_into CCO:B0013706 ! RANG_HUMAN-Phosphoserine60 [Term] id: CCO:B0005654 name: FBXW7_HUMAN def: "F-box/WD repeat-containing protein 7" [UniProtKB:Q969H0] synonym: "Archipelago homolog" EXACT [UniProtKB:Q969H0] synonym: "F-box and WD-40 domain-containing protein 7" EXACT [UniProtKB:Q969H0] synonym: "F-box protein FBX30" EXACT [UniProtKB:Q969H0] synonym: "hAgo" EXACT [UniProtKB:Q969H0] synonym: "hCdc4" EXACT [UniProtKB:Q969H0] synonym: "SEL-10" EXACT [UniProtKB:Q969H0] xref: EMBL:AAG16640.1 xref: EMBL:AAH37320.1 xref: EMBL:AAI17245.1 xref: EMBL:AAI17247.1 xref: EMBL:AAK57547.1 xref: EMBL:AAK60269.1 xref: EMBL:AAL06290.1 xref: EMBL:AAL06291.1 xref: EMBL:AAL07271.1 xref: EMBL:BAA91986.1 xref: EMBL:CAH18160.1 xref: UniProtKB:Q68DR0 xref: UniProtKB:Q969H0 xref: UniProtKB:Q96A16 xref: UniProtKB:Q96LE0 xref: UniProtKB:Q96RI2 xref: UniProtKB:Q9NUX6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004628 ! FBXW7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006786 ! myc-fbxw7 physical interaction relationship: participates_in CCO:I0008778 ! fbw7-skp1 physical interaction relationship: transforms_into CCO:B0011874 ! FBXW7_HUMAN-Phosphoserine26 [Term] id: CCO:B0005656 name: DTL_HUMAN def: "Denticleless protein homolog" [UniProtKB:Q9NZJ0] synonym: "Ddb1- and Cul4-associated factor 2" EXACT [UniProtKB:Q9NZJ0] synonym: "Lethal(2) denticleless protein homolog" EXACT [UniProtKB:Q9NZJ0] synonym: "Retinoic acid-regulated nuclear matrix-associated protein" EXACT [UniProtKB:Q9NZJ0] xref: EMBL:AAF35182.1 xref: EMBL:AAH33297.1 xref: EMBL:AAH33540.1 xref: EMBL:AAK54706.1 xref: EMBL:ABG23317.1 xref: EMBL:BAA91355.1 xref: EMBL:BAA91552.1 xref: EMBL:BAA91586.1 xref: EMBL:BAB55267.1 xref: EMBL:CAH70697.1 xref: EMBL:CAH73803.1 xref: UniProtKB:Q5VT77 xref: UniProtKB:Q96SN0 xref: UniProtKB:Q9NW03 xref: UniProtKB:Q9NW34 xref: UniProtKB:Q9NWM5 xref: UniProtKB:Q9NZJ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004516 ! DTL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006808 ! cul4b-ddb1-2 physical interaction relationship: participates_in CCO:I0006817 ! l2dtl-cul4b physical interaction relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: participates_in CCO:I0008525 ! l2dt1-ddb1 physical interaction relationship: participates_in CCO:I0008530 ! l2dtl-ddb1 physical interaction relationship: transforms_into CCO:B0011594 ! DTL_HUMAN-Phosphoserine426 relationship: transforms_into CCO:B0011595 ! DTL_HUMAN-Phosphothreonine516 relationship: transforms_into CCO:B0011596 ! DTL_HUMAN-Phosphoserine599 relationship: transforms_into CCO:B0011597 ! DTL_HUMAN-Phosphoserine717 [Term] id: CCO:B0005657 name: TLE2_HUMAN def: "Transducin-like enhancer protein 2" [UniProtKB:Q04725] synonym: "ESG2" EXACT [UniProtKB:Q04725] xref: EMBL:AAA61193.1 xref: EMBL:AAD38075.1 xref: EMBL:AAH17364.1 xref: UniProtKB:Q04725 xref: UniProtKB:Q8WVY0 xref: UniProtKB:Q9Y6S0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005789 ! TLE2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006809 ! cul4b-tle2 physical interaction relationship: participates_in CCO:I0006818 ! tle2-ddb1-1 physical interaction relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction relationship: participates_in CCO:I0008522 ! tle2-ddb1 physical interaction relationship: transforms_into CCO:B0014394 ! TLE2_HUMAN-Phosphoserine228 relationship: transforms_into CCO:B0014395 ! TLE2_HUMAN-Phosphoserine249 relationship: transforms_into CCO:B0014396 ! TLE2_HUMAN-Phosphothreonine253 [Term] id: CCO:B0005658 name: DDB2_HUMAN def: "DNA damage-binding protein 2" [UniProtKB:Q92466] synonym: "Damage-specific DNA-binding protein 2" EXACT [UniProtKB:Q92466] synonym: "DDB p48 subunit" EXACT [UniProtKB:Q92466] synonym: "DDBb" EXACT [UniProtKB:Q92466] synonym: "UV-damaged DNA-binding protein 2" EXACT [UniProtKB:Q92466] synonym: "UV-DDB 2" EXACT [UniProtKB:Q92466] xref: EMBL:AAB07897.1 xref: EMBL:AAH00093.1 xref: EMBL:AAO25655.1 xref: EMBL:AAP35803.1 xref: EMBL:BAD12557.1 xref: EMBL:BAD12558.1 xref: EMBL:BAD12559.1 xref: EMBL:BAD12560.1 xref: UniProtKB:Q76E54 xref: UniProtKB:Q76E55 xref: UniProtKB:Q76E56 xref: UniProtKB:Q76E57 xref: UniProtKB:Q92466 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004451 ! DDB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006810 ! ddb1-ddb2-1 physical interaction relationship: participates_in CCO:I0006811 ! cul4a-ddb2 physical interaction relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: participates_in CCO:I0008523 ! ddb1-ddb2 physical interaction relationship: transforms_into CCO:B0011457 ! DDB2_HUMAN-Phosphoserine24 relationship: transforms_into CCO:B0011458 ! DDB2_HUMAN-Phosphoserine26 [Term] id: CCO:B0005659 name: O75530_HUMAN def: "Embryonic ectoderm development protein" [UniProtKB:O75530] synonym: "hEED" EXACT [UniProtKB:O75530] synonym: "WAIT-1" EXACT [UniProtKB:O75530] synonym: "WD protein associating with integrin cytoplasmic tails-1" EXACT [UniProtKB:O75530] xref: EMBL:AAC23685.1 xref: UniProtKB:O75530 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005983 ! EED_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006813 ! cul4a-eed physical interaction relationship: participates_in CCO:I0008526 ! eed-ddb1 physical interaction [Term] id: CCO:B0005660 name: RBBP5_HUMAN def: "Retinoblastoma-binding protein 5" [UniProtKB:Q15291] synonym: "RBBP-5" EXACT [UniProtKB:Q15291] synonym: "Retinoblastoma-binding protein RBQ-3" EXACT [UniProtKB:Q15291] xref: EMBL:CAA59446.1 xref: UniProtKB:Q15291 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005439 ! RBBP5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006816 ! cul4a-cul4b-3 physical interaction relationship: participates_in CCO:I0006819 ! rbbp5-cul4a physical interaction relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: participates_in CCO:I0008524 ! rbbp5-wdr5-1 physical interaction relationship: participates_in CCO:I0008569 ! mll-hcfc2-1 physical interaction relationship: transforms_into CCO:B0013720 ! RBBP5_HUMAN-Phosphoserine182 relationship: transforms_into CCO:B0013721 ! RBBP5_HUMAN-Phosphothreonine193 relationship: transforms_into CCO:B0013722 ! RBBP5_HUMAN-Phosphothreonine252 relationship: transforms_into CCO:B0013723 ! RBBP5_HUMAN-Phosphoserine350 relationship: transforms_into CCO:B0013724 ! RBBP5_HUMAN-Phosphoserine388 relationship: transforms_into CCO:B0013725 ! RBBP5_HUMAN-Phosphoserine389 relationship: transforms_into CCO:B0013726 ! RBBP5_HUMAN-Phosphoserine497 [Term] id: CCO:B0005661 name: IPO7_HUMAN def: "Importin-7" [UniProtKB:O95373] synonym: "Imp7" EXACT [UniProtKB:O95373] synonym: "Ran-binding protein 7" EXACT [UniProtKB:O95373] synonym: "RanBP7" EXACT [UniProtKB:O95373] xref: EMBL:AAC68903.1 xref: EMBL:AAI14930.1 xref: EMBL:CAB70698.1 xref: EMBL:CAC17609.1 xref: EMBL:EAW68593.1 xref: UniProtKB:A6NNM5 xref: UniProtKB:O95373 xref: UniProtKB:Q1RMF7 xref: UniProtKB:Q9H177 xref: UniProtKB:Q9NTE3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004901 ! IPO7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006829 ! ran-xpot-1 physical interaction relationship: transforms_into CCO:B0012427 ! IPO7_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0012428 ! IPO7_HUMAN-Phosphotyrosine311 [Term] id: CCO:B0005662 name: XPO2_HUMAN def: "Exportin-2" [UniProtKB:P55060] synonym: "Cellular apoptosis susceptibility protein" EXACT [UniProtKB:P55060] synonym: "Chromosome segregation 1-like protein" EXACT [UniProtKB:P55060] synonym: "Exp2" EXACT [UniProtKB:P55060] synonym: "Importin-alpha re-exporter" EXACT [UniProtKB:P55060] xref: EMBL:AAC35007.1 xref: EMBL:AAC35008.1 xref: EMBL:AAC35009.1 xref: EMBL:AAC35297.1 xref: EMBL:AAC50367.1 xref: EMBL:AAI08310.1 xref: EMBL:AAI09314.1 xref: EMBL:AAI09315.1 xref: EMBL:CAI19615.1 xref: EMBL:CAI42818.1 xref: UniProtKB:O75432 xref: UniProtKB:P55060 xref: UniProtKB:Q32M40 xref: UniProtKB:Q9H5B7 xref: UniProtKB:Q9NTS0 xref: UniProtKB:Q9UP98 xref: UniProtKB:Q9UP99 xref: UniProtKB:Q9UPA0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005941 ! CSE1L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006829 ! ran-xpot-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0008297 ! ppp5c-cse1l physical interaction relationship: transforms_into CCO:B0014715 ! XPO2_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0005663 name: TNPO1_HUMAN def: "Transportin-1" [UniProtKB:Q92973] synonym: "Importin beta-2" EXACT [UniProtKB:Q92973] synonym: "Karyopherin beta-2" EXACT [UniProtKB:Q92973] synonym: "M9 region interaction protein" EXACT [UniProtKB:Q92973] synonym: "MIP" EXACT [UniProtKB:Q92973] xref: EMBL:AAB58254.1 xref: EMBL:AAB68948.1 xref: EMBL:AAC50723.1 xref: EMBL:AAH40340.1 xref: UniProtKB:Q92957 xref: UniProtKB:Q92973 xref: UniProtKB:Q92975 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005801 ! TNPO1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006829 ! ran-xpot-1 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007310 ! ran-tnpo1-1 direct interaction [Term] id: CCO:B0005664 name: XPOT_HUMAN def: "Exportin-T" [UniProtKB:O43592] synonym: "Exportin(tRNA)" EXACT [UniProtKB:O43592] synonym: "tRNA exportin" EXACT [UniProtKB:O43592] xref: EMBL:AAC39793.1 xref: EMBL:AAH00950.1 xref: EMBL:AAH20569.1 xref: EMBL:CAA76202.1 xref: UniProtKB:A6NLH1 xref: UniProtKB:O43592 xref: UniProtKB:O43784 xref: UniProtKB:Q8WUG2 xref: UniProtKB:Q9BVS7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005943 ! XPOT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006829 ! ran-xpot-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction [Term] id: CCO:B0005665 name: XPO7_HUMAN def: "Exportin-7" [UniProtKB:Q9UIA9] synonym: "Exp7" EXACT [UniProtKB:Q9UIA9] synonym: "Ran-binding protein 16" EXACT [UniProtKB:Q9UIA9] xref: EMBL:AAF21771.1 xref: EMBL:AAH14219.1 xref: EMBL:AAH30785.1 xref: EMBL:BAA34465.1 xref: UniProtKB:O94846 xref: UniProtKB:Q6PJK9 xref: UniProtKB:Q8NEK7 xref: UniProtKB:Q9UIA9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005942 ! XPO7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006829 ! ran-xpot-1 physical interaction relationship: transforms_into CCO:B0014716 ! XPO7_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005666 name: SOS2_HUMAN def: "Son of sevenless homolog 2" [UniProtKB:Q07890] synonym: "SOS-2" EXACT [UniProtKB:Q07890] xref: EMBL:AAA35914.1 xref: EMBL:AAA91852.1 xref: UniProtKB:Q07890 xref: UniProtKB:Q15503 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005650 ! SOS2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006844 ! sos2-cd2ap-1 physical interaction [Term] id: CCO:B0005667 name: ELOC_HUMAN def: "Transcription elongation factor B polypeptide 1" [UniProtKB:Q15369] synonym: "EloC" EXACT [UniProtKB:Q15369] synonym: "Elongin 15 kDa subunit" EXACT [UniProtKB:Q15369] synonym: "Elongin-C" EXACT [UniProtKB:Q15369] synonym: "RNA polymerase II transcription factor SIII subunit C" EXACT [UniProtKB:Q15369] synonym: "SIII p15" EXACT [UniProtKB:Q15369] xref: EMBL:AAA67650.1 xref: EMBL:AAH13809.1 xref: EMBL:AAH93065.1 xref: EMBL:AAI00029.1 xref: EMBL:AAI00284.1 xref: UniProtKB:Q15369 xref: UniProtKB:Q567Q6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004562 ! TCEB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006845 ! tceb1-tceb2-vh1 physical interaction [Term] id: CCO:B0005668 name: ELOB_HUMAN def: "Transcription elongation factor B polypeptide 2" [UniProtKB:Q15370] synonym: "EloB" EXACT [UniProtKB:Q15370] synonym: "Elongin 18 kDa subunit" EXACT [UniProtKB:Q15370] synonym: "Elongin B" EXACT [UniProtKB:Q15370] synonym: "RNA polymerase II transcription factor SIII subunit B" EXACT [UniProtKB:Q15370] synonym: "SIII p18" EXACT [UniProtKB:Q15370] xref: EMBL:AAA75522.1 xref: EMBL:AAC08452.1 xref: EMBL:AAH13306.1 xref: EMBL:AAH65000.1 xref: UniProtKB:Q15370 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004561 ! TCEB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006845 ! tceb1-tceb2-vh1 physical interaction relationship: transforms_into CCO:B0011679 ! ELOB_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0005674 name: E2AK1_HUMAN def: "Eukaryotic translation initiation factor 2-alpha kinase 1" [UniProtKB:Q9BQI3] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9BQI3] synonym: "HCR" EXACT [UniProtKB:Q9BQI3] synonym: "Heme-controlled repressor" EXACT [UniProtKB:Q9BQI3] synonym: "Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase" EXACT [UniProtKB:Q9BQI3] synonym: "Heme-regulated inhibitor" EXACT [UniProtKB:Q9BQI3] synonym: "Hemin-sensitive initiation factor 2-alpha kinase" EXACT [UniProtKB:Q9BQI3] xref: EMBL:AAF18391.1 xref: EMBL:AAF66736.1 xref: EMBL:AAF70289.1 xref: EMBL:AAF71057.1 xref: EMBL:AAG09683.1 xref: EMBL:AAH06524.1 xref: EMBL:BAA92607.1 xref: EMBL:BAC11461.1 xref: EMBL:CAB66498.1 xref: EMBL:CAD39152.1 xref: UniProtKB:Q8NBW3 xref: UniProtKB:Q9BQI3 xref: UniProtKB:Q9HC02 xref: UniProtKB:Q9NYE0 xref: UniProtKB:Q9P0V6 xref: UniProtKB:Q9P1J5 xref: UniProtKB:Q9P2H8 xref: UniProtKB:Q9UHG4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004530 ! EIF2AK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006872 ! eif2ak1-cdc37-8 physical interaction relationship: transforms_into CCO:B0011606 ! E2AK1_HUMAN-Phosphoserine275 relationship: transforms_into CCO:B0011607 ! E2AK1_HUMAN-Phosphoserine276 relationship: transforms_into CCO:B0011608 ! E2AK1_HUMAN-Phosphoserine277 relationship: transforms_into CCO:B0011609 ! E2AK1_HUMAN-Phosphoserine278 relationship: transforms_into CCO:B0011610 ! E2AK1_HUMAN-Phosphothreonine488 [Term] id: CCO:B0005675 name: HIPK1_HUMAN def: "Homeodomain-interacting protein kinase 1" [UniProtKB:Q86Z02] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q86Z02] xref: EMBL:AAH28408.1 xref: EMBL:AAH33012.1 xref: EMBL:AAH36057.1 xref: EMBL:BAA31605.1 xref: EMBL:BAC57075.1 xref: EMBL:CAD38689.1 xref: UniProtKB:O75125 xref: UniProtKB:Q86Z02 xref: UniProtKB:Q8IYD7 xref: UniProtKB:Q8NDN5 xref: UniProtKB:Q8NEB6 xref: UniProtKB:Q8TBZ1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004808 ! HIPK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006873 ! tp53-hipk1-2 physical interaction relationship: participates_in CCO:I0007434 ! tp53-hipk1-1 physical interaction relationship: transforms_into CCO:B0012196 ! HIPK1_HUMAN-Phosphotyrosine352 [Term] id: CCO:B0005679 name: IF4A1_HUMAN def: "Eukaryotic initiation factor 4A-I" [UniProtKB:P60842] synonym: "ATP-dependent RNA helicase eIF4A-1" EXACT [UniProtKB:P60842] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P60842] synonym: "eIF-4A-I" EXACT [UniProtKB:P60842] synonym: "eIF4A-I" EXACT [UniProtKB:P60842] xref: EMBL:AAH09585.1 xref: EMBL:AAH73752.1 xref: EMBL:AAV38683.1 xref: EMBL:AAV38684.1 xref: EMBL:BAA02897.1 xref: UniProtKB:P04765 xref: UniProtKB:P60842 xref: UniProtKB:Q5U018 xref: UniProtKB:Q61516 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004862 ! EIF4A1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006888 ! eif4g2-eif4a1-1 direct interaction relationship: participates_in CCO:I0007603 ! eif4g2-eif4a1-2 direct interaction [Term] id: CCO:B0005680 name: AP2B_HUMAN def: "Transcription factor AP-2 beta" [UniProtKB:Q92481] synonym: "Activating enhancer-binding protein 2 beta" EXACT [UniProtKB:Q92481] synonym: "AP2-beta" EXACT [UniProtKB:Q92481] xref: EMBL:AAH37225.1 xref: EMBL:CAA64990.1 xref: EMBL:CAA71047.1 xref: EMBL:CAB41305.1 xref: EMBL:CAB89563.3 xref: EMBL:CAC01130.1 xref: EMBL:CAI20235.2 xref: UniProtKB:Q5JYX6 xref: UniProtKB:Q92481 xref: UniProtKB:Q9NQ63 xref: UniProtKB:Q9NU99 xref: UniProtKB:Q9UJI7 xref: UniProtKB:Q9Y214 xref: UniProtKB:Q9Y3K3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004074 ! TFAP2B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006892 ! cited2-tfap2b-1 physical interaction relationship: participates_in CCO:I0007919 ! ap2b-ubc9-1 physical interaction relationship: participates_in CCO:I0007922 ! ubc9-ap2b-1 physical interaction relationship: transforms_into CCO:B0010565 ! AP2B_HUMAN-Phosphoserine258 [Term] id: CCO:B0005681 name: CREB1_HUMAN def: "cAMP response element-binding protein" [UniProtKB:P16220] synonym: "CREB" EXACT [UniProtKB:P16220] xref: EMBL:AAA35715.1 xref: EMBL:AAA35716.1 xref: EMBL:AAA35717.1 xref: EMBL:AAB20597.1 xref: EMBL:AAD13869.1 xref: EMBL:AAH10636.1 xref: EMBL:CAA39151.1 xref: EMBL:CAA42620.1 xref: UniProtKB:P16220 xref: UniProtKB:P21934 xref: UniProtKB:Q9UMA7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004395 ! CREB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006907 ! atr-creb1-1 phosphorylation relationship: transforms_into CCO:B0011345 ! CREB1_HUMAN-Phosphoserine111 relationship: transforms_into CCO:B0011346 ! CREB1_HUMAN-Phosphothreonine119 relationship: transforms_into CCO:B0011347 ! CREB1_HUMAN-Phosphoserine133 relationship: transforms_into CCO:B0011348 ! CREB1_HUMAN-Phosphoserine142 [Term] id: CCO:B0005682 name: CENPH_HUMAN def: "Centromere protein H" [UniProtKB:Q9H3R5] synonym: "CENP-H" EXACT [UniProtKB:Q9H3R5] synonym: "Interphase centromere complex protein 35" EXACT [UniProtKB:Q9H3R5] xref: EMBL:AAH12024.1 xref: EMBL:AAH15355.1 xref: EMBL:BAB18635.1 xref: UniProtKB:Q9H3R5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004326 ! CENPH_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006909 ! cenph_kntc2_2 physical interaction relationship: participates_in CCO:I0006910 ! cenph_kntc2_4 physical interaction relationship: participates_in CCO:I0007456 ! cenph_kntc2_1 physical interaction [Term] id: CCO:B0005683 name: EDC4_HUMAN def: "Enhancer of mRNA-decapping protein 4" [UniProtKB:Q6P2E9] synonym: "Autoantigen Ge-1" EXACT [UniProtKB:Q6P2E9] synonym: "Autoantigen RCD-8" EXACT [UniProtKB:Q6P2E9] synonym: "Hedls" EXACT [UniProtKB:Q6P2E9] synonym: "Human enhancer of decapping large subunit" EXACT [UniProtKB:Q6P2E9] xref: EMBL:AAA21833.1 xref: EMBL:AAB51444.1 xref: EMBL:AAH43616.1 xref: EMBL:AAH53598.1 xref: EMBL:AAH64567.1 xref: EMBL:BAC87512.1 xref: UniProtKB:Q13025 xref: UniProtKB:Q13826 xref: UniProtKB:Q6P2E9 xref: UniProtKB:Q6ZR12 xref: UniProtKB:Q7Z6H7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004543 ! EDC4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006911 ! dcp1a-rcd8-xrn1 colocalization relationship: participates_in CCO:I0007016 ! upf1-rcd8 physical interaction relationship: transforms_into CCO:B0011625 ! EDC4_HUMAN-Phosphothreonine693 relationship: transforms_into CCO:B0011626 ! EDC4_HUMAN-Phosphoserine729 relationship: transforms_into CCO:B0011627 ! EDC4_HUMAN-Phosphoserine741 relationship: transforms_into CCO:B0011628 ! EDC4_HUMAN-Phosphoserine844 relationship: transforms_into CCO:B0011629 ! EDC4_HUMAN-Phosphoserine875 relationship: transforms_into CCO:B0011630 ! EDC4_HUMAN-Phosphoserine879 relationship: transforms_into CCO:B0011631 ! EDC4_HUMAN-Phosphoserine887 relationship: transforms_into CCO:B0011632 ! EDC4_HUMAN-Phosphoserine1067 relationship: transforms_into CCO:B0011633 ! EDC4_HUMAN-Phosphothreonine1072 [Term] id: CCO:B0005686 name: HNRPD_HUMAN def: "Heterogeneous nuclear ribonucleoprotein D0" [UniProtKB:Q14103] synonym: "AU-rich element RNA-binding protein 1" EXACT [UniProtKB:Q14103] synonym: "hnRNP D0" EXACT [UniProtKB:Q14103] xref: EMBL:AAA35781.1 xref: EMBL:AAB96683.1 xref: EMBL:AAC23474.1 xref: EMBL:AAC23475.1 xref: EMBL:AAC23476.1 xref: EMBL:AAH02401.1 xref: EMBL:AAH23977.1 xref: EMBL:AAH26015.1 xref: EMBL:AAY40913.1 xref: EMBL:BAA09522.1 xref: EMBL:BAA09523.1 xref: EMBL:BAA09524.1 xref: EMBL:BAA09525.1 xref: EMBL:CAA27544.1 xref: UniProtKB:P07029 xref: UniProtKB:Q01858 xref: UniProtKB:Q14100 xref: UniProtKB:Q14101 xref: UniProtKB:Q14102 xref: UniProtKB:Q14103 xref: UniProtKB:Q4W5A1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004818 ! HNRPD_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006928 ! hnrpd-ube2i-2 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007823 ! hnrpd-ube2i physical interaction relationship: transforms_into CCO:B0012222 ! HNRPD_HUMAN-Phosphoserine80 relationship: transforms_into CCO:B0012223 ! HNRPD_HUMAN-Phosphoserine82 relationship: transforms_into CCO:B0012224 ! HNRPD_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0012225 ! HNRPD_HUMAN-Phosphoserine87 relationship: transforms_into CCO:B0012226 ! HNRPD_HUMAN-Phosphothreonine91 relationship: transforms_into CCO:B0012227 ! HNRPD_HUMAN-Phosphoserine190 relationship: transforms_into CCO:B0012228 ! HNRPD_HUMAN-Phosphothreonine193 relationship: transforms_into CCO:B0012229 ! HNRPD_HUMAN-Omega-N-methylated arginine345 [Term] id: CCO:B0005687 name: GRWD1_HUMAN def: "Glutamate-rich WD repeat-containing protein 1" [UniProtKB:Q9BQ67] xref: EMBL:AAH02440.1 xref: EMBL:AAK17998.1 xref: UniProtKB:Q9BQ67 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004733 ! GRWD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: transforms_into CCO:B0011988 ! GRWD1_HUMAN-Phosphoserine119 relationship: transforms_into CCO:B0011989 ! GRWD1_HUMAN-Phosphoserine122 [Term] id: CCO:B0005688 name: WDR82_HUMAN def: "WD repeat-containing protein 82" [UniProtKB:Q6UXN9] synonym: "Swd2" EXACT [UniProtKB:Q6UXN9] xref: EMBL:AAQ88631.1 xref: EMBL:BAB85039.1 xref: UniProtKB:Q6UXN9 xref: UniProtKB:Q8TEB2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005928 ! WDR82_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: transforms_into CCO:B0014688 ! WDR82_HUMAN-Phosphoserine154 [Term] id: CCO:B0005689 name: WDR26_HUMAN def: "WD repeat-containing protein 26" [UniProtKB:Q9H7D7] synonym: "CUL4- and DDB1-associated WDR protein 2" EXACT [UniProtKB:Q9H7D7] synonym: "Myocardial ischemic preconditioning up-regulated protein 2" EXACT [UniProtKB:Q9H7D7] xref: EMBL:AAG35477.1 xref: EMBL:AAH31471.2 xref: EMBL:AAH34498.1 xref: EMBL:AAH52301.2 xref: EMBL:AAH63817.1 xref: EMBL:AAO67709.1 xref: EMBL:AAQ74770.1 xref: EMBL:ABK41102.1 xref: EMBL:BAB14955.1 xref: EMBL:BAD93124.1 xref: UniProtKB:A0MNN3 xref: UniProtKB:Q4G100 xref: UniProtKB:Q59EC4 xref: UniProtKB:Q5GLZ9 xref: UniProtKB:Q86UY4 xref: UniProtKB:Q9H3C2 xref: UniProtKB:Q9H7D7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005917 ! WDR26_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: participates_in CCO:I0008532 ! wdr26-ddb1 physical interaction relationship: transforms_into CCO:B0014673 ! WDR26_HUMAN-Phosphoserine121 [Term] id: CCO:B0005690 name: TLE3_HUMAN def: "Transducin-like enhancer protein 3" [UniProtKB:Q04726] synonym: "ESG3" EXACT [UniProtKB:Q04726] xref: EMBL:AAA61194.1 xref: EMBL:AAH41831.1 xref: EMBL:BAB13373.1 xref: UniProtKB:Q04726 xref: UniProtKB:Q8IVV6 xref: UniProtKB:Q8WVR2 xref: UniProtKB:Q9HCM5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005790 ! TLE3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction relationship: transforms_into CCO:B0014397 ! TLE3_HUMAN-Phosphoserine201 relationship: transforms_into CCO:B0014398 ! TLE3_HUMAN-Phosphoserine203 relationship: transforms_into CCO:B0014399 ! TLE3_HUMAN-Phosphoserine207 relationship: transforms_into CCO:B0014400 ! TLE3_HUMAN-Phosphoserine217 relationship: transforms_into CCO:B0014401 ! TLE3_HUMAN-Phosphoserine240 relationship: transforms_into CCO:B0014402 ! TLE3_HUMAN-Phosphoserine245 relationship: transforms_into CCO:B0014403 ! TLE3_HUMAN-Phosphothreonine259 relationship: transforms_into CCO:B0014404 ! TLE3_HUMAN-Phosphoserine263 relationship: transforms_into CCO:B0014405 ! TLE3_HUMAN-Phosphoserine267 relationship: transforms_into CCO:B0014406 ! TLE3_HUMAN-Phosphoserine286 relationship: transforms_into CCO:B0014407 ! TLE3_HUMAN-Phosphothreonine328 relationship: transforms_into CCO:B0014408 ! TLE3_HUMAN-Phosphothreonine334 relationship: transforms_into CCO:B0036038 ! TLE3_HUMAN-Phosphoserine205 relationship: transforms_into CCO:B0036039 ! TLE3_HUMAN-Phosphoserine292 [Term] id: CCO:B0005691 name: SMU1_HUMAN def: "WD40 repeat-containing protein SMU1" [UniProtKB:Q2TAY7] synonym: "Smu-1 suppressor of mec-8 and unc-52 protein homolog" EXACT [UniProtKB:Q2TAY7] xref: EMBL:AAH02876.1 xref: EMBL:AAI10655.1 xref: EMBL:BAA91822.1 xref: EMBL:BAB13956.1 xref: EMBL:CAI15554.1 xref: UniProtKB:Q2TAY7 xref: UniProtKB:Q9BU59 xref: UniProtKB:Q9HA96 xref: UniProtKB:Q9NVD1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005640 ! SMU1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006931 ! cul4b-ddb1 physical interaction [Term] id: CCO:B0005693 name: ARI4A_HUMAN def: "AT-rich interactive domain-containing protein 4A" [UniProtKB:P29374] synonym: "ARID domain-containing protein 4A" EXACT [UniProtKB:P29374] synonym: "RBBP-1" EXACT [UniProtKB:P29374] synonym: "Retinoblastoma-binding protein 1" EXACT [UniProtKB:P29374] xref: EMBL:AAB25833.1 xref: EMBL:AAB25834.1 xref: EMBL:AAB25835.2 xref: EMBL:AAB28543.1 xref: UniProtKB:P29374 xref: UniProtKB:Q15991 xref: UniProtKB:Q15992 xref: UniProtKB:Q15993 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004093 ! ARID4A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006936 ! brms1-arid4a physical interaction relationship: transforms_into CCO:B0010602 ! ARI4A_HUMAN-Phosphoserine1109 [Term] id: CCO:B0005694 name: SDS3_HUMAN def: "Sin3 histone deacetylase corepressor complex component SDS3" [UniProtKB:Q9H7L9] synonym: "45 kDa Sin3-associated polypeptide" EXACT [UniProtKB:Q9H7L9] synonym: "Suppressor of defective silencing 3 protein homolog" EXACT [UniProtKB:Q9H7L9] xref: EMBL:AAH30252.1 xref: EMBL:AAH98404.1 xref: EMBL:BAB14685.1 xref: EMBL:BAB15750.1 xref: UniProtKB:Q4KMQ5 xref: UniProtKB:Q8N6H0 xref: UniProtKB:Q9H7L9 xref: UniProtKB:Q9H8D2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005577 ! SUDS3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006937 ! brms1-sds3 physical interaction relationship: participates_in CCO:I0007097 ! hcfc1-sds3-1 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: participates_in CCO:I0007719 ! sds3-brms1 physical interaction relationship: transforms_into CCO:B0013982 ! SDS3_HUMAN-Phosphoserine45 relationship: transforms_into CCO:B0013983 ! SDS3_HUMAN-Phosphothreonine49 relationship: transforms_into CCO:B0013984 ! SDS3_HUMAN-Phosphothreonine55 relationship: transforms_into CCO:B0013985 ! SDS3_HUMAN-Phosphoserine234 relationship: transforms_into CCO:B0013986 ! SDS3_HUMAN-Phosphoserine236 relationship: transforms_into CCO:B0013987 ! SDS3_HUMAN-Phosphothreonine244 [Term] id: CCO:B0005695 name: NMI_HUMAN def: "N-myc-interactor" [UniProtKB:Q13287] synonym: "N-myc and STAT interactor" EXACT [UniProtKB:Q13287] synonym: "Nmi" EXACT [UniProtKB:Q13287] xref: EMBL:AAC12949.1 xref: EMBL:AAH01268.1 xref: EMBL:AAY15066.1 xref: UniProtKB:Q13287 xref: UniProtKB:Q53TI8 xref: UniProtKB:Q9BVE5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005199 ! NMI_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006940 ! brms1-nmi physical interaction relationship: participates_in CCO:I0007721 ! nmi-brms1 physical interaction relationship: participates_in CCO:I0007969 ! myc-nmi-1 physical interaction relationship: participates_in CCO:I0008681 ! nmi-psma1 physical interaction [Term] id: CCO:B0005696 name: DNJB6_HUMAN def: "DnaJ homolog subfamily B member 6" [UniProtKB:O75190] synonym: "Heat shock protein J2" EXACT [UniProtKB:O75190] synonym: "HHDJ1" EXACT [UniProtKB:O75190] synonym: "HSJ-2" EXACT [UniProtKB:O75190] synonym: "MRJ" EXACT [UniProtKB:O75190] synonym: "MSJ-1" EXACT [UniProtKB:O75190] xref: EMBL:AAD16010.1 xref: EMBL:AAD43194.1 xref: EMBL:AAF21257.1 xref: EMBL:AAH00177.1 xref: EMBL:AAH02446.1 xref: EMBL:AAS07392.1 xref: EMBL:AAS07393.1 xref: EMBL:BAA32209.1 xref: EMBL:BAA88769.1 xref: EMBL:BAA88770.1 xref: EMBL:BAD93096.1 xref: EMBL:BAD97321.1 xref: EMBL:CAB66642.1 xref: EMBL:CAG38529.1 xref: EMBL:EAL23923.1 xref: EMBL:EAL23924.1 xref: UniProtKB:A4D232 xref: UniProtKB:O75190 xref: UniProtKB:O95806 xref: UniProtKB:Q53EN8 xref: UniProtKB:Q59EF2 xref: UniProtKB:Q6FIC8 xref: UniProtKB:Q75MA2 xref: UniProtKB:Q9UIK6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004490 ! DNAJB6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006941 ! brms1-dnajb6 physical interaction relationship: participates_in CCO:I0007720 ! dnajb6-brms1 physical interaction relationship: transforms_into CCO:B0011552 ! DNJB6_HUMAN-Phosphoserine277 [Term] id: CCO:B0005697 name: IMA5_HUMAN def: "Importin subunit alpha-6" [UniProtKB:O15131] synonym: "Karyopherin subunit alpha-5" EXACT [UniProtKB:O15131] xref: EMBL:AAC51868.1 xref: EMBL:AAH47409.1 xref: EMBL:CAI20500.1 xref: UniProtKB:O15131 xref: UniProtKB:Q86X23 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004888 ! KPNA5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006942 ! brms1-kpna5 physical interaction relationship: participates_in CCO:I0007558 ! cdn1b-kpna5-1 physical interaction relationship: participates_in CCO:I0007559 ! cdn1b-kpna5-2 physical interaction relationship: participates_in CCO:I0007560 ! cdn1b-kpna5-3 physical interaction relationship: participates_in CCO:I0007741 ! cdn1b-kpna5-4 physical interaction relationship: participates_in CCO:I0007862 ! cdn1b-kpna5-5 physical interaction [Term] id: CCO:B0005698 name: HS90A_HUMAN def: "Heat shock protein HSP 90-alpha" [UniProtKB:P07900] synonym: "HSP 86" EXACT [UniProtKB:P07900] synonym: "Renal carcinoma antigen NY-REN-38" EXACT [UniProtKB:P07900] xref: EMBL:AAA36023.1 xref: EMBL:AAA63194.1 xref: EMBL:AAH00987.1 xref: EMBL:AAI21063.1 xref: EMBL:ABC40730.1 xref: EMBL:BAA13430.1 xref: EMBL:BAA13431.1 xref: EMBL:CAA30255.1 xref: EMBL:CAA33259.1 xref: EMBL:CAI64495.1 xref: EMBL:CAI64496.1 xref: UniProtKB:P07900 xref: UniProtKB:Q2PP14 xref: UniProtKB:Q5CAQ6 xref: UniProtKB:Q5CAQ7 xref: UniProtKB:Q9BVQ5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004830 ! HSP90AA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006943 ! brms1-hspa8 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007396 ! cdc37-hsp90 physical interaction relationship: transforms_into CCO:B0012263 ! HS90A_HUMAN-Phosphothreonine5 relationship: transforms_into CCO:B0012264 ! HS90A_HUMAN-Phosphothreonine7 relationship: transforms_into CCO:B0012265 ! HS90A_HUMAN-Phosphoserine231 relationship: transforms_into CCO:B0012266 ! HS90A_HUMAN-Phosphoserine252 relationship: transforms_into CCO:B0012267 ! HS90A_HUMAN-Phosphoserine263 relationship: transforms_into CCO:B0031331 ! HS90A_HUMAN-Phosphotyrosine313 relationship: transforms_into CCO:B0031332 ! HS90A_HUMAN-Phosphotyrosine492 [Term] id: CCO:B0005699 name: HSP7C_HUMAN def: "Heat shock cognate 71 kDa protein" [UniProtKB:P11142] synonym: "Heat shock 70 kDa protein 8" EXACT [UniProtKB:P11142] xref: EMBL:AAH16179.1 xref: EMBL:AAH16660.1 xref: EMBL:AAH19816.1 xref: EMBL:AAK17898.1 xref: EMBL:BAB18615.1 xref: EMBL:CAA68445.1 xref: UniProtKB:P11142 xref: UniProtKB:Q9H3R6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004838 ! HSPA8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006943 ! brms1-hspa8 physical interaction relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0008158 ! rgs2-hspa8 physical interaction relationship: transforms_into CCO:B0012276 ! HSP7C_HUMAN-Phosphotyrosine15 relationship: transforms_into CCO:B0012277 ! HSP7C_HUMAN-Phosphoserine153 relationship: transforms_into CCO:B0012278 ! HSP7C_HUMAN-Phosphothreonine477 relationship: transforms_into CCO:B0031334 ! HSP7C_HUMAN-Phosphotyrosine41 [Term] id: CCO:B0005701 name: HDA11_HUMAN def: "Histone deacetylase 11" [UniProtKB:Q96DB2] synonym: "EC 3.5.1.98" EXACT [UniProtKB:Q96DB2] synonym: "HD11" EXACT [UniProtKB:Q96DB2] xref: EMBL:AAH09676.1 xref: EMBL:BAB15127.1 xref: EMBL:BAB15272.1 xref: EMBL:CAB70712.1 xref: UniProtKB:Q96DB2 xref: UniProtKB:Q9H6I7 xref: UniProtKB:Q9H6X3 xref: UniProtKB:Q9NTC9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004785 ! HDAC11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006950 ! hdac6-hdac11-1 physical interaction relationship: participates_in CCO:I0008372 ! cdkn1a-hdac11 physical interaction [Term] id: CCO:B0005702 name: STK4_HUMAN def: "Serine/threonine-protein kinase 4" [UniProtKB:Q13043] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q13043] synonym: "Mammalian STE20-like protein kinase 1" EXACT [UniProtKB:Q13043] synonym: "MST-1" EXACT [UniProtKB:Q13043] synonym: "Serine/threonine-protein kinase Krs-2" EXACT [UniProtKB:Q13043] synonym: "STE20-like kinase MST1" EXACT [UniProtKB:Q13043] xref: EMBL:AAA83254.1 xref: EMBL:AAB17262.1 xref: EMBL:AAH29511.1 xref: EMBL:AAH58916.1 xref: EMBL:AAH93768.1 xref: EMBL:CAB07508.2 xref: EMBL:CAI19815.1 xref: EMBL:CAI95633.1 xref: EMBL:CAI95634.1 xref: UniProtKB:Q13043 xref: UniProtKB:Q15802 xref: UniProtKB:Q4G156 xref: UniProtKB:Q5H982 xref: UniProtKB:Q6PD60 xref: UniProtKB:Q9BR32 xref: UniProtKB:Q9NTZ4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005694 ! STK4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006951 ! stk4-rassf5-1 physical interaction relationship: transforms_into CCO:B0014254 ! STK4_HUMAN-Phosphothreonine183 relationship: transforms_into CCO:B0014255 ! STK4_HUMAN-Phosphoserine320 relationship: transforms_into CCO:B0014256 ! STK4_HUMAN-Phosphotyrosine433 [Term] id: CCO:B0005703 name: ABI1_HUMAN def: "Abl interactor 1" [UniProtKB:Q8IZP0] synonym: "Abelson interactor 1" EXACT [UniProtKB:Q8IZP0] synonym: "Abi-1" EXACT [UniProtKB:Q8IZP0] synonym: "Abl-binding protein 4" EXACT [UniProtKB:Q8IZP0] synonym: "AblBP4" EXACT [UniProtKB:Q8IZP0] synonym: "e3B1" EXACT [UniProtKB:Q8IZP0] synonym: "Eps8 SH3 domain-binding protein" EXACT [UniProtKB:Q8IZP0] synonym: "Eps8-binding protein" EXACT [UniProtKB:Q8IZP0] synonym: "Nap1-binding protein" EXACT [UniProtKB:Q8IZP0] synonym: "Nap1BP" EXACT [UniProtKB:Q8IZP0] synonym: "Spectrin SH3 domain-binding protein 1" EXACT [UniProtKB:Q8IZP0] xref: EMBL:AAB62569.1 xref: EMBL:AAC39757.1 xref: EMBL:AAD00897.1 xref: EMBL:AAF70309.1 xref: EMBL:AAH24254.1 xref: EMBL:AAN28379.1 xref: EMBL:BAB55675.1 xref: EMBL:CAB88006.1 xref: EMBL:CAH73117.1 xref: EMBL:CAH73119.1 xref: EMBL:CAI17273.1 xref: EMBL:CAI17279.1 xref: UniProtKB:O15147 xref: UniProtKB:O76049 xref: UniProtKB:O95060 xref: UniProtKB:Q5W070 xref: UniProtKB:Q5W072 xref: UniProtKB:Q8IZP0 xref: UniProtKB:Q8TB63 xref: UniProtKB:Q96S81 xref: UniProtKB:Q9NXZ9 xref: UniProtKB:Q9NYB8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004012 ! ABI1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006953 ! abi1-nckap1-1 physical interaction relationship: participates_in CCO:I0007069 ! abi1-abl1-2 physical interaction relationship: participates_in CCO:I0007527 ! abi1-abl1-1 physical interaction relationship: transforms_into CCO:B0010395 ! ABI1_HUMAN-Phosphoserine183 relationship: transforms_into CCO:B0010396 ! ABI1_HUMAN-Phosphoserine225 relationship: transforms_into CCO:B0010397 ! ABI1_HUMAN-Phosphotyrosine333 relationship: transforms_into CCO:B0031286 ! ABI1_HUMAN-Phosphotyrosine455 relationship: transforms_into CCO:B0041283 ! ABI1_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005704 name: ZYX_HUMAN def: "Zyxin" [UniProtKB:Q15942] synonym: "Zyxin-2" EXACT [UniProtKB:Q15942] xref: EMBL:AAH08743.1 xref: EMBL:AAH09360.1 xref: EMBL:AAH10031.1 xref: EMBL:AAS07459.1 xref: EMBL:CAA64447.1 xref: EMBL:CAA65050.1 xref: EMBL:CAG33712.1 xref: UniProtKB:Q15942 xref: UniProtKB:Q6I9S4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005976 ! ZYX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006954 ! lats1-zyx-1 physical interaction relationship: participates_in CCO:I0007236 ! lats1-zyx-6 colocalization relationship: participates_in CCO:I0007728 ! lats1-zyx-4 physical interaction relationship: participates_in CCO:I0007950 ! lats1-zyx-2 physical interaction relationship: participates_in CCO:I0007951 ! lats1-zyx-3 physical interaction relationship: participates_in CCO:I0007952 ! lats1-zyx-5 physical interaction relationship: participates_in CCO:I0007953 ! lats1-zyx-7 physical interaction relationship: participates_in CCO:I0007958 ! lats1-zyx-8 physical interaction relationship: participates_in CCO:I0007959 ! lats1-zyx-9 physical interaction relationship: participates_in CCO:I0007960 ! lats1-zyx-10 physical interaction relationship: transforms_into CCO:B0014769 ! ZYX_HUMAN-Phosphoserine142 relationship: transforms_into CCO:B0014770 ! ZYX_HUMAN-Phosphoserine143 relationship: transforms_into CCO:B0014771 ! ZYX_HUMAN-Phosphothreonine159 relationship: transforms_into CCO:B0014772 ! ZYX_HUMAN-Phosphothreonine179 relationship: transforms_into CCO:B0014773 ! ZYX_HUMAN-Phosphoserine259 relationship: transforms_into CCO:B0014774 ! ZYX_HUMAN-Phosphoserine267 relationship: transforms_into CCO:B0014775 ! ZYX_HUMAN-Phosphoserine281 relationship: transforms_into CCO:B0014776 ! ZYX_HUMAN-Phosphoserine290 relationship: transforms_into CCO:B0014777 ! ZYX_HUMAN-Phosphoserine308 relationship: transforms_into CCO:B0014778 ! ZYX_HUMAN-Phosphoserine344 relationship: transforms_into CCO:B0041223 ! ZYX_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005705 name: MYOD1_HUMAN def: "Myoblast determination protein 1" [UniProtKB:P15172] synonym: "Myf-3" EXACT [UniProtKB:P15172] synonym: "Myogenic factor 3" EXACT [UniProtKB:P15172] xref: EMBL:CAA35640.1 xref: EMBL:CAA40000.1 xref: UniProtKB:P15172 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005147 ! MYOD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006958 ! sirt2-pcaf-myod1-2 physical interaction relationship: participates_in CCO:I0007536 ! sirt2-pcaf-myod1-1 physical interaction [Term] id: CCO:B0005706 name: M4K2_HUMAN def: "Mitogen-activated protein kinase kinase kinase kinase 2" [UniProtKB:Q12851] synonym: "B lymphocyte serine/threonine-protein kinase" EXACT [UniProtKB:Q12851] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q12851] synonym: "GC kinase" EXACT [UniProtKB:Q12851] synonym: "Germinal center kinase" EXACT [UniProtKB:Q12851] synonym: "MAPK/ERK kinase kinase kinase 2" EXACT [UniProtKB:Q12851] synonym: "MEK kinase kinase 2" EXACT [UniProtKB:Q12851] synonym: "MEKKK 2" EXACT [UniProtKB:Q12851] synonym: "Rab8-interacting protein" EXACT [UniProtKB:Q12851] xref: EMBL:AAA20968.1 xref: UniProtKB:Q12851 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005011 ! MAP4K2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006963 ! map4k2-mlk3-1 physical interaction relationship: transforms_into CCO:B0012745 ! M4K2_HUMAN-Phosphoserine327 relationship: transforms_into CCO:B0041158 ! M4K2_HUMAN-Phosphoserine393 [Term] id: CCO:B0005708 name: ARAF_HUMAN def: "A-Raf proto-oncogene serine/threonine-protein kinase" [UniProtKB:P10398] synonym: "A-raf-1" EXACT [UniProtKB:P10398] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P10398] synonym: "Proto-oncogene Pks" EXACT [UniProtKB:P10398] xref: EMBL:AAA65219.1 xref: EMBL:AAB03517.1 xref: EMBL:AAB08754.1 xref: EMBL:AAH02466.1 xref: EMBL:AAV38667.1 xref: EMBL:CAA28476.1 xref: EMBL:CAI42468.1 xref: UniProtKB:P07557 xref: UniProtKB:P10398 xref: UniProtKB:Q5H9B3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004087 ! ARAF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006965 ! araf-pbk physical interaction relationship: participates_in CCO:I0007554 ! araf-pbk-1 physical interaction relationship: participates_in CCO:I0007555 ! araf-pbk-2 physical interaction relationship: transforms_into CCO:B0010585 ! ARAF_HUMAN-Phosphoserine257 relationship: transforms_into CCO:B0010586 ! ARAF_HUMAN-Phosphoserine582 [Term] id: CCO:B0005709 name: HUWE1_HUMAN def: "E3 ubiquitin-protein ligase HUWE1" [UniProtKB:Q7Z6Z7] synonym: "ARF-binding protein 1" EXACT [UniProtKB:Q7Z6Z7] synonym: "ARF-BP1" EXACT [UniProtKB:Q7Z6Z7] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q7Z6Z7] synonym: "HECT, UBA and WWE domain-containing protein 1" EXACT [UniProtKB:Q7Z6Z7] synonym: "Mcl-1 ubiquitin ligase E3" EXACT [UniProtKB:Q7Z6Z7] synonym: "Mule" EXACT [UniProtKB:Q7Z6Z7] synonym: "URE-B1" EXACT [UniProtKB:Q7Z6Z7] xref: EMBL:AAC62492.1 xref: EMBL:AAF28950.1 xref: EMBL:AAH02602.2 xref: EMBL:AAH63505.1 xref: EMBL:AAV90838.1 xref: EMBL:AAX24125.1 xref: EMBL:AAY98258.1 xref: EMBL:BAA20771.2 xref: EMBL:BAB13404.1 xref: EMBL:BAC06833.1 xref: EMBL:CAB82393.1 xref: EMBL:CAG33094.1 xref: EMBL:CAI39580.1 xref: EMBL:CAI42354.1 xref: EMBL:CAI42654.1 xref: UniProtKB:O15029 xref: UniProtKB:Q4G2Z2 xref: UniProtKB:Q5H961 xref: UniProtKB:Q6P4D0 xref: UniProtKB:Q7Z6Z7 xref: UniProtKB:Q8NG67 xref: UniProtKB:Q9BUI0 xref: UniProtKB:Q9HCJ4 xref: UniProtKB:Q9NSL6 xref: UniProtKB:Q9P0A9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004844 ! HUWE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006970 ! huew1-tp53-1 physical interaction relationship: participates_in CCO:I0006971 ! tp53-huew1-2 physical interaction relationship: participates_in CCO:I0007256 ! huew1-cdkn2a-1 physical interaction relationship: participates_in CCO:I0007257 ! cdkn2a-huew1-3 physical interaction relationship: participates_in CCO:I0007426 ! cdkn2a-huew1-2 physical interaction relationship: participates_in CCO:I0007568 ! tp53-huew1-1 physical interaction relationship: participates_in CCO:I0007874 ! cdkn2a-huew1-1 physical interaction relationship: transforms_into CCO:B0012287 ! HUWE1_HUMAN-Phosphoserine1395 relationship: transforms_into CCO:B0012288 ! HUWE1_HUMAN-Phosphoserine1907 relationship: transforms_into CCO:B0012289 ! HUWE1_HUMAN-Phosphoserine2362 relationship: transforms_into CCO:B0012290 ! HUWE1_HUMAN-Phosphoserine2377 relationship: transforms_into CCO:B0012291 ! HUWE1_HUMAN-Phosphoserine2887 relationship: transforms_into CCO:B0012292 ! HUWE1_HUMAN-Phosphoserine2918 relationship: transforms_into CCO:B0012293 ! HUWE1_HUMAN-Phosphoserine3757 relationship: transforms_into CCO:B0012294 ! HUWE1_HUMAN-Phosphoserine3797 relationship: transforms_into CCO:B0012295 ! HUWE1_HUMAN-Phosphoserine3808 relationship: transforms_into CCO:B0012296 ! HUWE1_HUMAN-Phosphoserine3816 relationship: transforms_into CCO:B0012297 ! HUWE1_HUMAN-Phosphothreonine3822 relationship: transforms_into CCO:B0012298 ! HUWE1_HUMAN-Phosphoserine3919 relationship: transforms_into CCO:B0012299 ! HUWE1_HUMAN-Phosphothreonine3924 relationship: transforms_into CCO:B0012300 ! HUWE1_HUMAN-Phosphothreonine3927 relationship: transforms_into CCO:B0012301 ! HUWE1_HUMAN-Phosphotyrosine4271 [Term] id: CCO:B0005710 name: ZHANG_HUMAN def: "CREB/ATF bZIP transcription factor" [UniProtKB:Q9NS37] synonym: "HCF-binding transcription factor Zhangfei" EXACT [UniProtKB:Q9NS37] synonym: "Host cell factor-binding transcription factor Zhangfei" EXACT [UniProtKB:Q9NS37] xref: EMBL:AAD28325.1 xref: EMBL:AAH93796.1 xref: EMBL:AAH93798.1 xref: EMBL:AAZ42189.1 xref: UniProtKB:Q52LT3 xref: UniProtKB:Q9NS37 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005955 ! CREBZF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006973 ! hcfc1-zf-1 physical interaction relationship: participates_in CCO:I0006974 ! hcfc1-zf-3 physical interaction relationship: participates_in CCO:I0007265 ! hcfc1-zf-6 direct interaction relationship: participates_in CCO:I0007267 ! hcfc1-zf-7 direct interaction relationship: participates_in CCO:I0007754 ! hcfc1-zf-4 physical interaction relationship: participates_in CCO:I0007755 ! hcfc1-zf-5 physical interaction relationship: participates_in CCO:I0007875 ! hcfc1-zf-2 physical interaction [Term] id: CCO:B0005711 name: P3C2B_HUMAN def: "Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide" [UniProtKB:O00750] synonym: "C2-PI3K" EXACT [UniProtKB:O00750] synonym: "EC 2.7.1.154" EXACT [UniProtKB:O00750] synonym: "Phosphoinositide 3-Kinase-C2-beta" EXACT [UniProtKB:O00750] synonym: "PI3K-C2beta" EXACT [UniProtKB:O00750] synonym: "PtdIns-3-kinase C2 beta" EXACT [UniProtKB:O00750] xref: EMBL:CAA72168.1 xref: EMBL:CAA74194.1 xref: EMBL:CAI16572.1 xref: UniProtKB:O00750 xref: UniProtKB:O95666 xref: UniProtKB:Q5SW99 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005244 ! PIK3C2B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006978 ! egfr-pik3c2b-2 physical interaction relationship: participates_in CCO:I0006979 ! egfr-pik3c2b-5 physical interaction relationship: participates_in CCO:I0007428 ! egfr-pik3c2b-3 direct interaction relationship: participates_in CCO:I0007429 ! egfr-pik3c2b-6 direct interaction relationship: participates_in CCO:I0007570 ! egfr-pik3c2b-4 physical interaction relationship: participates_in CCO:I0007877 ! egfr-pik3c2a-1 physical interaction relationship: participates_in CCO:I0007878 ! egfr-pik3c2b-1 physical interaction [Term] id: CCO:B0005712 name: ADA17_HUMAN def: "ADAM 17 precursor" [UniProtKB:P78536] synonym: "A disintegrin and metalloproteinase domain 17" EXACT [UniProtKB:P78536] synonym: "CD156b antigen" EXACT [UniProtKB:P78536] synonym: "EC 3.4.24.86" EXACT [UniProtKB:P78536] synonym: "Snake venom-like protease" EXACT [UniProtKB:P78536] synonym: "TNF-alpha convertase" EXACT [UniProtKB:P78536] synonym: "TNF-alpha-converting enzyme" EXACT [UniProtKB:P78536] xref: EMBL:AAB51514.1 xref: EMBL:AAB51586.1 xref: EMBL:AAB53014.1 xref: EMBL:AAC39721.1 xref: UniProtKB:O60226 xref: UniProtKB:P78536 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004027 ! ADAM17_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006988 ! adam17-mad2l1-1 physical interaction relationship: participates_in CCO:I0006989 ! adam17-mad2l1-3 physical interaction relationship: participates_in CCO:I0007360 ! adam17-mad2l1-2 physical interaction relationship: transforms_into CCO:B0010453 ! ADA17_HUMAN-Phosphotyrosine379 relationship: transforms_into CCO:B0010454 ! ADA17_HUMAN-Phosphoserine382 relationship: transforms_into CCO:B0010455 ! ADA17_HUMAN-Phosphothreonine735 relationship: transforms_into CCO:B0010456 ! ADA17_HUMAN-Phosphoserine791 relationship: transforms_into CCO:B0010457 ! ADA17_HUMAN-Phosphoserine819 [Term] id: CCO:B0005713 name: ANM1_HUMAN def: "Protein arginine N-methyltransferase 1" [UniProtKB:Q99873] synonym: "EC 2.1.1.-" EXACT [UniProtKB:Q99873] synonym: "Interferon receptor 1-bound protein 4" EXACT [UniProtKB:Q99873] xref: EMBL:AAF62893.1 xref: EMBL:AAF62894.1 xref: EMBL:AAF62895.1 xref: EMBL:BAA11029.1 xref: EMBL:CAA71763.1 xref: EMBL:CAA71764.1 xref: EMBL:CAA71765.1 xref: UniProtKB:Q15529 xref: UniProtKB:Q99872 xref: UniProtKB:Q99873 xref: UniProtKB:Q99874 xref: UniProtKB:Q9NZ04 xref: UniProtKB:Q9NZ05 xref: UniProtKB:Q9NZ06 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004063 ! PRMT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006991 ! hrmt1l2-ilf3-2 methylation relationship: participates_in CCO:I0007785 ! hrmt1l2-ilf3-3 physical interaction relationship: participates_in CCO:I0008014 ! hrmt1l2-rif1 physical interaction relationship: participates_in CCO:I0008767 ! hrmt1l2-hmga2 physical interaction [Term] id: CCO:B0005714 name: BNI3L_HUMAN def: "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like" [UniProtKB:O60238] synonym: "Adenovirus E1B19K-binding protein B5" EXACT [UniProtKB:O60238] synonym: "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A" EXACT [UniProtKB:O60238] synonym: "NIP3-like protein X" EXACT [UniProtKB:O60238] synonym: "NIP3L" EXACT [UniProtKB:O60238] xref: EMBL:AAC27723.1 xref: EMBL:AAD03589.1 xref: EMBL:AAF70290.1 xref: EMBL:AAH01559.1 xref: EMBL:AAH09603.1 xref: EMBL:AAL50978.1 xref: EMBL:AAN04051.1 xref: EMBL:AAV38308.1 xref: EMBL:BAA28692.1 xref: UniProtKB:O60238 xref: UniProtKB:Q8NF87 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004176 ! BNIP3L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008498 ! rint1-bnip3l physical interaction relationship: transforms_into CCO:B0010816 ! BNI3L_HUMAN-Phosphoserine62 relationship: transforms_into CCO:B0010817 ! BNI3L_HUMAN-Phosphoserine63 relationship: transforms_into CCO:B0010818 ! BNI3L_HUMAN-Phosphoserine117 relationship: transforms_into CCO:B0010819 ! BNI3L_HUMAN-Phosphoserine120 [Term] id: CCO:B0005715 name: ITF2_HUMAN def: "Transcription factor 4" [UniProtKB:P15884] synonym: "Immunoglobulin transcription factor 2" EXACT [UniProtKB:P15884] synonym: "ITF-2" EXACT [UniProtKB:P15884] synonym: "SEF-2" EXACT [UniProtKB:P15884] synonym: "SL3-3 enhancer factor 2" EXACT [UniProtKB:P15884] xref: EMBL:AAA60310.1 xref: EMBL:AAA60311.1 xref: EMBL:AAA60312.1 xref: EMBL:AAC51824.1 xref: EMBL:AAI25085.1 xref: EMBL:AAI25086.1 xref: EMBL:CAA36298.1 xref: UniProtKB:P15884 xref: UniProtKB:Q08AP2 xref: UniProtKB:Q08AP3 xref: UniProtKB:Q15439 xref: UniProtKB:Q15440 xref: UniProtKB:Q15441 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004905 ! TCF4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007000 ! cdc73-tcf4 physical interaction [Term] id: CCO:B0005717 name: EDC3_HUMAN def: "Enhancer of mRNA-decapping protein 3" [UniProtKB:Q96F86] synonym: "LSM16 homolog" EXACT [UniProtKB:Q96F86] synonym: "YjeF domain-containing protein 1" EXACT [UniProtKB:Q96F86] xref: EMBL:AAG22486.1 xref: EMBL:AAH11534.1 xref: EMBL:AAH21271.1 xref: EMBL:BAB15001.1 xref: UniProtKB:Q96F86 xref: UniProtKB:Q9H797 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004542 ! EDC3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007016 ! upf1-rcd8 physical interaction relationship: transforms_into CCO:B0011624 ! EDC3_HUMAN-Phosphoserine131 [Term] id: CCO:B0005720 name: MSH3_HUMAN def: "DNA mismatch repair protein Msh3" [UniProtKB:P20585] synonym: "Divergent upstream protein" EXACT [UniProtKB:P20585] synonym: "DUP" EXACT [UniProtKB:P20585] synonym: "Mismatch repair protein 1" EXACT [UniProtKB:P20585] synonym: "MRP1" EXACT [UniProtKB:P20585] xref: EMBL:AAB06045.1 xref: EMBL:AAB47281.1 xref: EMBL:AAH11817.1 xref: EMBL:AAP13535.1 xref: EMBL:BAD27111.1 xref: UniProtKB:P20585 xref: UniProtKB:Q6PJT5 xref: UniProtKB:Q86UQ6 xref: UniProtKB:Q92867 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005127 ! MSH3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007028 ! msh2-msh3 physical interaction relationship: participates_in CCO:I0007029 ! msh3-msh2-1 physical interaction relationship: participates_in CCO:I0007033 ! msh3-msh2-2 physical interaction relationship: participates_in CCO:I0007035 ! msh3-msh2-3 physical interaction relationship: transforms_into CCO:B0013015 ! MSH3_HUMAN-Phosphoserine201 [Term] id: CCO:B0005721 name: WAPL_HUMAN def: "Wings apart-like protein homolog" [UniProtKB:Q7Z5K2] synonym: "Friend of EBNA2 protein" EXACT [UniProtKB:Q7Z5K2] xref: EMBL:AAO14651.1 xref: EMBL:BAA13391.1 xref: EMBL:BAC78631.1 xref: EMBL:CAH73376.1 xref: EMBL:CAI16708.1 xref: UniProtKB:Q5VSK5 xref: UniProtKB:Q7Z5K2 xref: UniProtKB:Q8IX10 xref: UniProtKB:Q92549 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005910 ! WAPAL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007036 ! wapl-cspg6 physical interaction relationship: participates_in CCO:I0007037 ! wapl-cspg6-3 physical interaction relationship: participates_in CCO:I0007039 ! wapl-cspg6-1 physical interaction relationship: participates_in CCO:I0007040 ! wapl-cspg6-2 physical interaction relationship: participates_in CCO:I0007711 ! wapl-cspg6-4 physical interaction relationship: participates_in CCO:I0007712 ! wapl-cspg6-5 physical interaction relationship: participates_in CCO:I0007713 ! wapl-cspg6-6 physical interaction relationship: participates_in CCO:I0007714 ! wapl-cspg6-7 physical interaction relationship: participates_in CCO:I0007715 ! wapl-cspg6-9 physical interaction relationship: transforms_into CCO:B0014649 ! WAPL_HUMAN-Phosphoserine77 relationship: transforms_into CCO:B0014650 ! WAPL_HUMAN-Phosphoserine221 relationship: transforms_into CCO:B0014651 ! WAPL_HUMAN-Phosphoserine226 relationship: transforms_into CCO:B0014652 ! WAPL_HUMAN-Phosphoserine459 relationship: transforms_into CCO:B0014653 ! WAPL_HUMAN-Phosphoserine461 relationship: transforms_into CCO:B0036040 ! WAPL_HUMAN-Phosphoserine223 [Term] id: CCO:B0005723 name: MTR1A_HUMAN def: "Melatonin receptor type 1A" [UniProtKB:P48039] synonym: "Mel-1A-R" EXACT [UniProtKB:P48039] synonym: "Mel1a melatonin receptor" EXACT [UniProtKB:P48039] xref: EMBL:AAB17720.1 xref: EMBL:AAH74946.1 xref: EMBL:AAH74947.1 xref: EMBL:AAI26298.1 xref: EMBL:AAI26300.1 xref: EMBL:BAA85303.1 xref: UniProtKB:A0AVC5 xref: UniProtKB:P48039 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005134 ! MTNR1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007051 ! mit1a-ef1-fila physical interaction [Term] id: CCO:B0005724 name: MTR1B_HUMAN def: "Melatonin receptor type 1B" [UniProtKB:P49286] synonym: "Mel-1B-R" EXACT [UniProtKB:P49286] synonym: "Mel1b melatonin receptor" EXACT [UniProtKB:P49286] xref: EMBL:AAC50612.1 xref: EMBL:AAH69163.1 xref: EMBL:AAS00461.1 xref: EMBL:BAA92315.1 xref: UniProtKB:P49286 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005135 ! MTNR1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007052 ! mit1b-ef1-fila-1 physical interaction [Term] id: CCO:B0005725 name: ROA2_HUMAN def: "Heterogeneous nuclear ribonucleoproteins A2/B1" [UniProtKB:P22626] synonym: "hnRNP A2 / hnRNP B1" EXACT [UniProtKB:P22626] xref: EMBL:AAA36574.1 xref: EMBL:AAA60271.1 xref: EMBL:AAB60650.1 xref: EMBL:BAA06031.1 xref: EMBL:BAA06032.1 xref: UniProtKB:P22626 xref: UniProtKB:P22627 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006369 ! HNRNPA2B1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013923 ! ROA2_HUMAN-Phosphothreonine176 relationship: transforms_into CCO:B0013924 ! ROA2_HUMAN-Omega-N-methylarginine203 relationship: transforms_into CCO:B0013925 ! ROA2_HUMAN-Phosphoserine212 relationship: transforms_into CCO:B0013926 ! ROA2_HUMAN-Phosphoserine259 relationship: transforms_into CCO:B0013927 ! ROA2_HUMAN-Phosphoserine341 relationship: transforms_into CCO:B0013928 ! ROA2_HUMAN-Phosphoserine344 relationship: transforms_into CCO:B0013929 ! ROA2_HUMAN-Phosphotyrosine347 [Term] id: CCO:B0005726 name: RS24_HUMAN def: "40S ribosomal protein S24" [UniProtKB:P62847] xref: EMBL:AAA36588.1 xref: EMBL:AAB08006.1 xref: EMBL:AAB08007.1 xref: EMBL:AAH00523.1 xref: EMBL:AAH71926.1 xref: UniProtKB:P16632 xref: UniProtKB:P62847 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005535 ! RPS24_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013940 ! RS24_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0031372 ! RS24_HUMAN-Phosphotyrosine81 [Term] id: CCO:B0005727 name: TBB5_HUMAN def: "Tubulin beta chain" [UniProtKB:P07437] synonym: "Tubulin beta-5 chain" EXACT [UniProtKB:P07437] xref: EMBL:AAB59507.1 xref: EMBL:AAC28642.1 xref: EMBL:AAC28650.1 xref: EMBL:AAC28654.1 xref: EMBL:AAD33873.1 xref: EMBL:AAH01938.1 xref: EMBL:AAH02347.1 xref: EMBL:AAH05838.1 xref: EMBL:AAH07605.1 xref: EMBL:AAH13374.1 xref: EMBL:AAH19924.1 xref: EMBL:AAH20946.1 xref: EMBL:AAH21909.1 xref: EMBL:AAH70326.1 xref: EMBL:BAB63321.1 xref: EMBL:BAB93480.1 xref: EMBL:BAC54932.1 xref: UniProtKB:P05218 xref: UniProtKB:P07437 xref: UniProtKB:Q8WUC1 xref: UniProtKB:Q9CY33 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005737 ! TUBB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0014317 ! TBB5_HUMAN-Phosphotyrosine36 relationship: transforms_into CCO:B0031380 ! TBB5_HUMAN-Phosphotyrosine340 [Term] id: CCO:B0005728 name: IF4A2_HUMAN def: "Eukaryotic initiation factor 4A-II" [UniProtKB:Q14240] synonym: "ATP-dependent RNA helicase eIF4A-2" EXACT [UniProtKB:Q14240] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q14240] synonym: "eIF-4A-II" EXACT [UniProtKB:Q14240] synonym: "eIF4A-II" EXACT [UniProtKB:Q14240] xref: EMBL:AAH12547.1 xref: EMBL:AAH13708.1 xref: EMBL:AAH15842.1 xref: EMBL:AAH48105.1 xref: EMBL:BAA06336.1 xref: UniProtKB:Q14240 xref: UniProtKB:Q96B90 xref: UniProtKB:Q96EA8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004863 ! EIF4A2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007328 ! eif4gii-eif4aii physical interaction [Term] id: CCO:B0005729 name: DDX5_HUMAN def: "Probable ATP-dependent RNA helicase DDX5" [UniProtKB:P17844] synonym: "DEAD box protein 5" EXACT [UniProtKB:P17844] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P17844] synonym: "RNA helicase p68" EXACT [UniProtKB:P17844] xref: EMBL:AAB84094.1 xref: EMBL:AAH16027.1 xref: EMBL:AAP35589.1 xref: EMBL:CAA09408.1 xref: EMBL:CAA33751.1 xref: EMBL:CAA36324.1 xref: UniProtKB:O75681 xref: UniProtKB:P17844 xref: UniProtKB:Q53Y61 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004459 ! DDX5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0011481 ! DDX5_HUMAN-Phosphoserine30 relationship: transforms_into CCO:B0011482 ! DDX5_HUMAN-Phosphotyrosine297 relationship: transforms_into CCO:B0011483 ! DDX5_HUMAN-Omega-N-methylated arginine502 relationship: transforms_into CCO:B0011484 ! DDX5_HUMAN-Phosphothreonine507 relationship: transforms_into CCO:B0011485 ! DDX5_HUMAN-Phosphoserine520 [Term] id: CCO:B0005730 name: CH60_HUMAN def: "60 kDa heat shock protein, mitochondrial precursor" [UniProtKB:P10809] synonym: "60 kDa chaperonin" EXACT [UniProtKB:P10809] synonym: "Chaperonin 60" EXACT [UniProtKB:P10809] synonym: "CPN60" EXACT [UniProtKB:P10809] synonym: "Heat shock protein 60" EXACT [UniProtKB:P10809] synonym: "HSP-60" EXACT [UniProtKB:P10809] synonym: "Hsp60" EXACT [UniProtKB:P10809] synonym: "HuCHA60" EXACT [UniProtKB:P10809] synonym: "Mitochondrial matrix protein P1" EXACT [UniProtKB:P10809] synonym: "P60 lymphocyte protein" EXACT [UniProtKB:P10809] xref: EMBL:AAA36022.1 xref: EMBL:AAA60127.1 xref: EMBL:AAH02676.1 xref: EMBL:AAH03030.1 xref: EMBL:AAH67082.1 xref: EMBL:AAH73746.1 xref: EMBL:ABB01006.1 xref: EMBL:CAB75426.1 xref: UniProtKB:P10809 xref: UniProtKB:Q38L19 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004343 ! HSPD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0011197 ! CH60_HUMAN-Phosphoserine70 relationship: transforms_into CCO:B0011198 ! CH60_HUMAN-Phosphotyrosine223 relationship: transforms_into CCO:B0011199 ! CH60_HUMAN-Phosphotyrosine227 [Term] id: CCO:B0005731 name: ANXA6_HUMAN def: "Annexin A6" [UniProtKB:P08133] synonym: "67 kDa calelectrin" EXACT [UniProtKB:P08133] synonym: "Annexin VI" EXACT [UniProtKB:P08133] synonym: "Annexin-6" EXACT [UniProtKB:P08133] synonym: "Calphobindin-II" EXACT [UniProtKB:P08133] synonym: "Chromobindin-20" EXACT [UniProtKB:P08133] synonym: "CPB-II" EXACT [UniProtKB:P08133] synonym: "Lipocortin VI" EXACT [UniProtKB:P08133] synonym: "P68" EXACT [UniProtKB:P08133] synonym: "P70" EXACT [UniProtKB:P08133] synonym: "Protein III" EXACT [UniProtKB:P08133] xref: EMBL:AAA35656.1 xref: EMBL:AAH17046.1 xref: EMBL:BAA00400.1 xref: EMBL:BAC86715.1 xref: EMBL:CAA68286.1 xref: UniProtKB:P08133 xref: UniProtKB:Q6ZT79 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004071 ! ANXA6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0010562 ! ANXA6_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0031291 ! ANXA6_HUMAN-Phosphotyrosine30 relationship: transforms_into CCO:B0031292 ! ANXA6_HUMAN-Phosphotyrosine201 [Term] id: CCO:B0005732 name: HNRH1_HUMAN def: "Heterogeneous nuclear ribonucleoprotein H" [UniProtKB:P31943] synonym: "hnRNP H" EXACT [UniProtKB:P31943] xref: EMBL:AAA91346.1 xref: EMBL:AAH01348.1 xref: UniProtKB:P31943 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004815 ! HNRPH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0012200 ! HNRH1_HUMAN-N-acetylmethionine2 relationship: transforms_into CCO:B0012201 ! HNRH1_HUMAN-Phosphoserine23 relationship: transforms_into CCO:B0012202 ! HNRH1_HUMAN-Phosphoserine63 relationship: transforms_into CCO:B0012203 ! HNRH1_HUMAN-Phosphothreonine100 relationship: transforms_into CCO:B0012204 ! HNRH1_HUMAN-Phosphoserine104 relationship: transforms_into CCO:B0012205 ! HNRH1_HUMAN-Asymmetric dimethylarginine217 relationship: transforms_into CCO:B0012206 ! HNRH1_HUMAN-Phosphotyrosine246 relationship: transforms_into CCO:B0012207 ! HNRH1_HUMAN-Phosphotyrosine306 relationship: transforms_into CCO:B0012208 ! HNRH1_HUMAN-Phosphoserine310 [Term] id: CCO:B0005733 name: NUCL_HUMAN def: "Nucleolin" [UniProtKB:P19338] synonym: "Protein C23" EXACT [UniProtKB:P19338] xref: EMBL:AAA59954.1 xref: EMBL:AAY24247.1 xref: EMBL:BAC03738.1 xref: UniProtKB:P19338 xref: UniProtKB:Q53SK1 xref: UniProtKB:Q8NB06 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005220 ! NCL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: participates_in CCO:I0007294 ! pa2g4-ncl-1 physical interaction relationship: transforms_into CCO:B0013269 ! NUCL_HUMAN-Phosphoserine28 relationship: transforms_into CCO:B0013270 ! NUCL_HUMAN-Phosphoserine34 relationship: transforms_into CCO:B0013271 ! NUCL_HUMAN-Phosphoserine41 relationship: transforms_into CCO:B0013272 ! NUCL_HUMAN-Phosphoserine42 relationship: transforms_into CCO:B0013273 ! NUCL_HUMAN-Phosphoserine67 relationship: transforms_into CCO:B0013274 ! NUCL_HUMAN-Phosphothreonine69 relationship: transforms_into CCO:B0013275 ! NUCL_HUMAN-Phosphothreonine76 relationship: transforms_into CCO:B0013276 ! NUCL_HUMAN-Phosphothreonine121 relationship: transforms_into CCO:B0013277 ! NUCL_HUMAN-Phosphoserine145 relationship: transforms_into CCO:B0013278 ! NUCL_HUMAN-Phosphoserine153 relationship: transforms_into CCO:B0013279 ! NUCL_HUMAN-Phosphoserine184 relationship: transforms_into CCO:B0013280 ! NUCL_HUMAN-Phosphothreonine214 relationship: transforms_into CCO:B0013281 ! NUCL_HUMAN-Phosphoserine563 relationship: transforms_into CCO:B0013282 ! NUCL_HUMAN-Phosphoserine580 relationship: transforms_into CCO:B0013283 ! NUCL_HUMAN-Phosphoserine619 relationship: transforms_into CCO:B0026383 ! NUCL_HUMAN-Phosphothreonine99 relationship: transforms_into CCO:B0026384 ! NUCL_HUMAN-Phosphothreonine105 relationship: transforms_into CCO:B0031361 ! NUCL_HUMAN-Phosphoserine206 [Term] id: CCO:B0005734 name: RS8_HUMAN def: "40S ribosomal protein S8" [UniProtKB:P62241] xref: EMBL:AAH70875.1 xref: EMBL:BAB93488.1 xref: EMBL:CAA47670.1 xref: UniProtKB:P09058 xref: UniProtKB:P62241 xref: UniProtKB:Q6IRL7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005539 ! RPS8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013944 ! RS8_HUMAN-Phosphoserine160 [Term] id: CCO:B0005736 name: ANXA2_HUMAN def: "Annexin A2" [UniProtKB:P07355] synonym: "Annexin II" EXACT [UniProtKB:P07355] synonym: "Annexin-2" EXACT [UniProtKB:P07355] synonym: "Calpactin I heavy chain" EXACT [UniProtKB:P07355] synonym: "Chromobindin-8" EXACT [UniProtKB:P07355] synonym: "Lipocortin II" EXACT [UniProtKB:P07355] synonym: "p36" EXACT [UniProtKB:P07355] synonym: "PAP-IV" EXACT [UniProtKB:P07355] synonym: "Placental anticoagulant protein IV" EXACT [UniProtKB:P07355] synonym: "Protein I" EXACT [UniProtKB:P07355] xref: EMBL:AAH01388.1 xref: EMBL:AAH09564.1 xref: EMBL:AAH15834.1 xref: EMBL:AAH16774.1 xref: EMBL:AAH21114.1 xref: EMBL:AAH52558.1 xref: EMBL:AAH52567.1 xref: EMBL:AAH66955.2 xref: EMBL:AAH68065.1 xref: EMBL:AAH93056.1 xref: EMBL:AAP36100.1 xref: EMBL:BAA00013.1 xref: UniProtKB:P07355 xref: UniProtKB:Q567R4 xref: UniProtKB:Q96DD5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004069 ! ANXA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0010556 ! ANXA2_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0010557 ! ANXA2_HUMAN-Phosphoserine18 relationship: transforms_into CCO:B0010558 ! ANXA2_HUMAN-Phosphothreonine19 relationship: transforms_into CCO:B0010559 ! ANXA2_HUMAN-Phosphotyrosine24 relationship: transforms_into CCO:B0010560 ! ANXA2_HUMAN-Phosphoserine26 relationship: transforms_into CCO:B0010561 ! ANXA2_HUMAN-Phosphotyrosine30 [Term] id: CCO:B0005737 name: VIME_HUMAN def: "Vimentin" [UniProtKB:P08670] xref: EMBL:AAA61279.1 xref: EMBL:AAA61281.2 xref: EMBL:AAA61282.1 xref: EMBL:AAH00163.2 xref: EMBL:AAH30573.1 xref: EMBL:AAH66956.1 xref: EMBL:AAN09720.1 xref: EMBL:BAB71275.1 xref: EMBL:BAC05002.1 xref: EMBL:BAD96227.1 xref: EMBL:BAD96322.1 xref: EMBL:BAF83332.1 xref: EMBL:CAA34499.1 xref: EMBL:CAA39600.1 xref: EMBL:CAA79613.2 xref: EMBL:CAB87963.1 xref: EMBL:CAG28618.1 xref: EMBL:EAW86215.1 xref: UniProtKB:P08670 xref: UniProtKB:Q15867 xref: UniProtKB:Q15868 xref: UniProtKB:Q15869 xref: UniProtKB:Q548L2 xref: UniProtKB:Q6LER9 xref: UniProtKB:Q8N850 xref: UniProtKB:Q96ML2 xref: UniProtKB:Q9NTM3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005903 ! VIM_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0008118 ! hmg20b-vim physical interaction relationship: participates_in CCO:I0008127 ! kif15-vim physical interaction relationship: participates_in CCO:I0008155 ! rad51-vim physical interaction relationship: participates_in CCO:I0008186 ! vim-rif1 physical interaction relationship: participates_in CCO:I0008686 ! psma1-vim physical interaction relationship: participates_in CCO:I0008800 ! psme1-vim physical interaction relationship: transforms_into CCO:B0014619 ! VIME_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0014620 ! VIME_HUMAN-Phosphoserine5 relationship: transforms_into CCO:B0014621 ! VIME_HUMAN-Phosphoserine7 relationship: transforms_into CCO:B0014622 ! VIME_HUMAN-Phosphoserine8 relationship: transforms_into CCO:B0014623 ! VIME_HUMAN-Phosphoserine9 relationship: transforms_into CCO:B0014624 ! VIME_HUMAN-Phosphoserine10 relationship: transforms_into CCO:B0014625 ! VIME_HUMAN-Phosphoserine25 relationship: transforms_into CCO:B0014626 ! VIME_HUMAN-Phosphoserine26 relationship: transforms_into CCO:B0014627 ! VIME_HUMAN-Phosphoserine27 relationship: transforms_into CCO:B0014628 ! VIME_HUMAN-Phosphoserine34 relationship: transforms_into CCO:B0014629 ! VIME_HUMAN-Phosphoserine39 relationship: transforms_into CCO:B0014630 ! VIME_HUMAN-Phosphoserine42 relationship: transforms_into CCO:B0014631 ! VIME_HUMAN-Phosphoserine47 relationship: transforms_into CCO:B0014632 ! VIME_HUMAN-Phosphoserine51 relationship: transforms_into CCO:B0014633 ! VIME_HUMAN-Phosphoserine55 relationship: transforms_into CCO:B0014634 ! VIME_HUMAN-Phosphoserine56 relationship: transforms_into CCO:B0014635 ! VIME_HUMAN-Phosphotyrosine61 relationship: transforms_into CCO:B0014636 ! VIME_HUMAN-Phosphoserine66 relationship: transforms_into CCO:B0014637 ! VIME_HUMAN-Phosphoserine72 relationship: transforms_into CCO:B0014638 ! VIME_HUMAN-Phosphoserine73 relationship: transforms_into CCO:B0014639 ! VIME_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0014640 ! VIME_HUMAN-Phosphotyrosine117 relationship: transforms_into CCO:B0014641 ! VIME_HUMAN-Phosphoserine214 relationship: transforms_into CCO:B0014642 ! VIME_HUMAN-Phosphoserine412 relationship: transforms_into CCO:B0014643 ! VIME_HUMAN-Phosphoserine420 relationship: transforms_into CCO:B0014644 ! VIME_HUMAN-Phosphoserine430 relationship: transforms_into CCO:B0014645 ! VIME_HUMAN-Phosphothreonine446 relationship: transforms_into CCO:B0014646 ! VIME_HUMAN-Phosphothreonine458 relationship: transforms_into CCO:B0014647 ! VIME_HUMAN-Phosphoserine459 relationship: transforms_into CCO:B0031384 ! VIME_HUMAN-Phosphotyrosine53 [Term] id: CCO:B0005738 name: VDAC3_HUMAN def: "Voltage-dependent anion-selective channel protein 3" [UniProtKB:Q9Y277] synonym: "hVDAC3" EXACT [UniProtKB:Q9Y277] synonym: "Outer mitochondrial membrane protein porin 3" EXACT [UniProtKB:Q9Y277] synonym: "VDAC-3" EXACT [UniProtKB:Q9Y277] xref: EMBL:AAB93872.1 xref: EMBL:AAC39876.1 xref: EMBL:AAD49610.1 xref: EMBL:AAH56870.1 xref: UniProtKB:Q9UIS0 xref: UniProtKB:Q9Y277 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005896 ! VDAC3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0014605 ! VDAC3_HUMAN-N6-acetyllysine20 relationship: transforms_into CCO:B0014606 ! VDAC3_HUMAN-Phosphothreonine33 relationship: transforms_into CCO:B0014607 ! VDAC3_HUMAN-N6-acetyllysine61 relationship: transforms_into CCO:B0014608 ! VDAC3_HUMAN-Phosphotyrosine195 relationship: transforms_into CCO:B0014609 ! VDAC3_HUMAN-Phosphoserine241 relationship: transforms_into CCO:B0031383 ! VDAC3_HUMAN-Phosphotyrosine48 [Term] id: CCO:B0005739 name: GBLP_HUMAN def: "Guanine nucleotide-binding protein subunit beta-2-like 1" [UniProtKB:P63244] synonym: "Guanine nucleotide-binding protein subunit beta-like protein 12.3" EXACT [UniProtKB:P63244] synonym: "RACK1" EXACT [UniProtKB:P63244] synonym: "Receptor for activated C kinase" EXACT [UniProtKB:P63244] synonym: "Receptor of activated protein kinase C 1" EXACT [UniProtKB:P63244] xref: EMBL:AAA59626.1 xref: EMBL:AAH00214.1 xref: EMBL:AAH00366.1 xref: EMBL:AAH10119.1 xref: EMBL:AAH14256.1 xref: EMBL:AAH14788.1 xref: EMBL:AAH17287.1 xref: EMBL:AAH19093.1 xref: EMBL:AAH19362.1 xref: EMBL:AAH21993.1 xref: EMBL:AAH32006.1 xref: EMBL:CAG33259.1 xref: UniProtKB:P25388 xref: UniProtKB:P63244 xref: UniProtKB:P99049 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004688 ! GNB2L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0008371 ! cdkn1a-gnb2l1 physical interaction relationship: transforms_into CCO:B0011923 ! GBLP_HUMAN-N-acetylthreonine2 relationship: transforms_into CCO:B0011924 ! GBLP_HUMAN-Phosphotyrosine228 [Term] id: CCO:B0005740 name: CD4_HUMAN def: "T-cell surface glycoprotein CD4 precursor" [UniProtKB:P01730] synonym: "T-cell surface antigen T4/Leu-3" EXACT [UniProtKB:P01730] xref: EMBL:AAA16069.1 xref: EMBL:AAA35572.1 xref: EMBL:AAB51309.1 xref: EMBL:AAH25782.1 xref: EMBL:AAV38594.1 xref: EMBL:AAV38614.1 xref: EMBL:AAY22175.1 xref: UniProtKB:P01730 xref: UniProtKB:Q4ZGK2 xref: UniProtKB:Q5U066 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004278 ! CD4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction [Term] id: CCO:B0005741 name: RL18_HUMAN def: "60S ribosomal protein L18" [UniProtKB:Q07020] xref: EMBL:AAA16329.1 xref: EMBL:AAH00374.1 xref: EMBL:AAH09708.1 xref: EMBL:AAH21743.1 xref: EMBL:BAB79463.1 xref: UniProtKB:Q07020 xref: UniProtKB:Q8WTZ6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005500 ! RPL18_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0013886 ! RL18_HUMAN-Phosphoserine130 [Term] id: CCO:B0005742 name: YBOX1_HUMAN def: "Nuclease-sensitive element-binding protein 1" [UniProtKB:P67809] synonym: "CBF-A" EXACT [UniProtKB:P67809] synonym: "CCAAT-binding transcription factor I subunit A" EXACT [UniProtKB:P67809] synonym: "DBPB" EXACT [UniProtKB:P67809] synonym: "DNA-binding protein B" EXACT [UniProtKB:P67809] synonym: "EFI-A" EXACT [UniProtKB:P67809] synonym: "Enhancer factor I subunit A" EXACT [UniProtKB:P67809] synonym: "Y-box transcription factor" EXACT [UniProtKB:P67809] synonym: "Y-box-binding protein 1" EXACT [UniProtKB:P67809] synonym: "YB-1" EXACT [UniProtKB:P67809] xref: EMBL:AAA20871.1 xref: EMBL:AAA35750.1 xref: EMBL:AAA59949.1 xref: EMBL:AAA61308.1 xref: EMBL:AAH02411.1 xref: EMBL:AAH10430.1 xref: EMBL:AAH15208.1 xref: EMBL:AAH38384.1 xref: EMBL:AAH65571.1 xref: EMBL:AAH70084.1 xref: EMBL:AAH71708.1 xref: EMBL:AAH90038.1 xref: EMBL:AAH98435.1 xref: EMBL:AAI06046.1 xref: UniProtKB:P16990 xref: UniProtKB:P16991 xref: UniProtKB:P67809 xref: UniProtKB:Q14972 xref: UniProtKB:Q15325 xref: UniProtKB:Q5FVF0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005948 ! YBX1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0014723 ! YBOX1_HUMAN-Phosphoserine102 relationship: transforms_into CCO:B0014724 ! YBOX1_HUMAN-Phosphotyrosine162 relationship: transforms_into CCO:B0014725 ! YBOX1_HUMAN-Phosphoserine165 relationship: transforms_into CCO:B0014726 ! YBOX1_HUMAN-Phosphoserine174 relationship: transforms_into CCO:B0014727 ! YBOX1_HUMAN-Phosphoserine176 relationship: transforms_into CCO:B0014728 ! YBOX1_HUMAN-Phosphoserine314 relationship: transforms_into CCO:B0031385 ! YBOX1_HUMAN-Phosphoserine167 [Term] id: CCO:B0005743 name: MYL6_HUMAN def: "Myosin light polypeptide 6" [UniProtKB:P60660] synonym: "LC17" EXACT [UniProtKB:P60660] synonym: "MLC-3" EXACT [UniProtKB:P60660] synonym: "Myosin light chain 3" EXACT [UniProtKB:P60660] synonym: "Myosin light chain alkali 3" EXACT [UniProtKB:P60660] synonym: "Smooth muscle and nonmuscle myosin light chain alkali 6" EXACT [UniProtKB:P60660] xref: EMBL:AAA20643.1 xref: EMBL:AAA36347.1 xref: EMBL:AAA36348.1 xref: EMBL:AAA59853.1 xref: EMBL:AAA59892.1 xref: EMBL:AAA59893.1 xref: EMBL:AAH06781.2 xref: EMBL:AAH17455.1 xref: EMBL:AAH71661.1 xref: EMBL:BAB62402.1 xref: EMBL:CAG33295.1 xref: UniProtKB:P16475 xref: UniProtKB:P24572 xref: UniProtKB:P24573 xref: UniProtKB:P60660 xref: UniProtKB:Q12790 xref: UniProtKB:Q6IAZ0 xref: UniProtKB:Q6IPY5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005144 ! MYL6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013067 ! MYL6_HUMAN-N-acetylcysteine2 [Term] id: CCO:B0005744 name: RS19_HUMAN def: "40S ribosomal protein S19" [UniProtKB:P39019] xref: EMBL:AAA89070.1 xref: EMBL:AAD13668.1 xref: EMBL:AAH00023.1 xref: EMBL:AAH07615.1 xref: EMBL:AAH18616.1 xref: EMBL:BAA28593.1 xref: UniProtKB:P39019 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005533 ! RPS19_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction [Term] id: CCO:B0005746 name: RL7_HUMAN def: "60S ribosomal protein L7" [UniProtKB:P18124] xref: EMBL:AAA03081.1 xref: EMBL:AAH06095.1 xref: EMBL:AAH08850.1 xref: EMBL:AAH09599.1 xref: EMBL:AAH71671.1 xref: EMBL:AAH71894.1 xref: EMBL:AAH71895.1 xref: EMBL:AAH87837.1 xref: EMBL:CAA37139.1 xref: EMBL:CAA41026.1 xref: EMBL:CAA41027.1 xref: EMBL:CAG33054.1 xref: UniProtKB:P18124 xref: UniProtKB:Q15289 xref: UniProtKB:Q5I0X1 xref: UniProtKB:Q6IBM9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005509 ! RPL7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013892 ! RL7_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0013893 ! RL7_HUMAN-Phosphotyrosine139 relationship: transforms_into CCO:B0013894 ! RL7_HUMAN-Phosphotyrosine195 [Term] id: CCO:B0005748 name: RS13_HUMAN def: "40S ribosomal protein S13" [UniProtKB:P62277] xref: EMBL:AAA60283.1 xref: EMBL:AAC15854.1 xref: EMBL:AAH00475.1 xref: EMBL:AAH06772.1 xref: EMBL:AAH29732.1 xref: EMBL:AAH66322.1 xref: EMBL:AAI00033.1 xref: EMBL:BAA13528.1 xref: EMBL:CAA55821.1 xref: UniProtKB:P19116 xref: UniProtKB:P62277 xref: UniProtKB:Q02546 xref: UniProtKB:Q29200 xref: UniProtKB:Q498Y0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005531 ! RPS13_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013935 ! RS13_HUMAN-Phosphotyrosine38 relationship: transforms_into CCO:B0013936 ! RS13_HUMAN-Phosphotyrosine128 relationship: transforms_into CCO:B0013937 ! RS13_HUMAN-Phosphotyrosine129 relationship: transforms_into CCO:B0036030 ! RS13_HUMAN-Phosphoserine30 [Term] id: CCO:B0005749 name: RS10_HUMAN def: "40S ribosomal protein S10" [UniProtKB:P46783] xref: EMBL:AAA85660.1 xref: EMBL:AAH01032.1 xref: EMBL:AAH01955.1 xref: EMBL:AAH05012.1 xref: EMBL:AAH70235.1 xref: EMBL:AAH71946.1 xref: EMBL:AAH73799.1 xref: EMBL:BAA25817.1 xref: EMBL:CAH73100.1 xref: UniProtKB:P46783 xref: UniProtKB:Q5TZC0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005529 ! RPS10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013932 ! RS10_HUMAN-Phosphotyrosine12 relationship: transforms_into CCO:B0013933 ! RS10_HUMAN-Phosphoserine146 [Term] id: CCO:B0005750 name: RS9_HUMAN def: "40S ribosomal protein S9" [UniProtKB:P46781] xref: EMBL:AAA85659.1 xref: EMBL:AAH00802.1 xref: EMBL:AAH07410.1 xref: EMBL:AAH07434.1 xref: EMBL:AAH07857.1 xref: EMBL:AAH68055.1 xref: EMBL:AAH71940.1 xref: EMBL:AAH96756.1 xref: EMBL:BAA25816.1 xref: EMBL:BAB79477.1 xref: UniProtKB:P46781 xref: UniProtKB:Q4QRK7 xref: UniProtKB:Q9BVZ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005540 ! RPS9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction [Term] id: CCO:B0005751 name: RL22_HUMAN def: "60S ribosomal protein L22" [UniProtKB:P35268] synonym: "EAP" EXACT [UniProtKB:P35268] synonym: "EBER-associated protein" EXACT [UniProtKB:P35268] synonym: "Epstein-Barr virus small RNA-associated protein" EXACT [UniProtKB:P35268] synonym: "Heparin-binding protein HBp15" EXACT [UniProtKB:P35268] xref: EMBL:AAH35566.1 xref: EMBL:AAH58887.1 xref: EMBL:AAH66314.1 xref: EMBL:BAA04545.1 xref: EMBL:CAA42007.1 xref: EMBL:CAG33154.1 xref: EMBL:CAI19448.1 xref: EMBL:EAW71518.1 xref: UniProtKB:P35268 xref: UniProtKB:Q6IBD1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005502 ! RPL22_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction [Term] id: CCO:B0005752 name: EF1B_HUMAN def: "Elongation factor 1-beta" [UniProtKB:P24534] synonym: "EF-1-beta" EXACT [UniProtKB:P24534] xref: EMBL:AAH00211.1 xref: EMBL:AAH04931.1 xref: EMBL:AAH67787.1 xref: EMBL:AAP35742.1 xref: EMBL:AAY15062.1 xref: EMBL:CAA43019.1 xref: EMBL:CAA43063.1 xref: EMBL:CAG33106.1 xref: UniProtKB:P24534 xref: UniProtKB:Q6IBH9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004546 ! EEF1B2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0011642 ! EF1B_HUMAN-Phosphothreonine93 relationship: transforms_into CCO:B0011643 ! EF1B_HUMAN-Phosphoserine95 relationship: transforms_into CCO:B0011644 ! EF1B_HUMAN-Phosphoserine106 relationship: transforms_into CCO:B0011645 ! EF1B_HUMAN-Phosphotyrosine126 relationship: transforms_into CCO:B0011646 ! EF1B_HUMAN-Phosphoserine128 relationship: transforms_into CCO:B0011647 ! EF1B_HUMAN-Phosphoserine141 [Term] id: CCO:B0005753 name: SYFB_HUMAN def: "Phenylalanyl-tRNA synthetase beta chain" [UniProtKB:Q9NSD9] synonym: "EC 6.1.1.20" EXACT [UniProtKB:Q9NSD9] synonym: "Phenylalanine--tRNA ligase beta chain" EXACT [UniProtKB:Q9NSD9] synonym: "PheRS" EXACT [UniProtKB:Q9NSD9] xref: EMBL:AAD02220.1 xref: EMBL:AAF29136.1 xref: EMBL:AAH17783.1 xref: EMBL:BAA95608.1 xref: UniProtKB:O95708 xref: UniProtKB:Q9NSD9 xref: UniProtKB:Q9NZZ6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006371 ! FARSB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction [Term] id: CCO:B0005754 name: GNAI2_HUMAN def: "Guanine nucleotide-binding protein G(i), alpha-2 subunit" [UniProtKB:P04899] synonym: "Adenylate cyclase-inhibiting G alpha protein" EXACT [UniProtKB:P04899] xref: EMBL:AAA35894.1 xref: EMBL:AAA52556.1 xref: EMBL:AAH12138.1 xref: EMBL:AAH16995.1 xref: EMBL:AAM12620.1 xref: EMBL:CAA28512.1 xref: EMBL:CAA30703.1 xref: UniProtKB:P04899 xref: UniProtKB:Q8IZ71 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004710 ! GNAI2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0011951 ! GNAI2_HUMAN-ADP-ribosylarginine179 relationship: transforms_into CCO:B0011952 ! GNAI2_HUMAN-ADP-ribosylcysteine352 [Term] id: CCO:B0005755 name: LPPRC_HUMAN def: "Leucine-rich PPR motif-containing protein, mitochondrial precursor" [UniProtKB:P42704] synonym: "130 kDa leucine-rich protein" EXACT [UniProtKB:P42704] synonym: "GP130" EXACT [UniProtKB:P42704] synonym: "LRP 130" EXACT [UniProtKB:P42704] xref: EMBL:AAA67549.1 xref: EMBL:AAH50311.1 xref: EMBL:AAI30286.1 xref: EMBL:AAP41922.1 xref: EMBL:BAC86287.1 xref: UniProtKB:P42704 xref: UniProtKB:Q6ZUD8 xref: UniProtKB:Q7Z7A6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004987 ! LRPPRC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction [Term] id: CCO:B0005756 name: DHRS2_HUMAN def: "Dehydrogenase/reductase SDR family member 2" [UniProtKB:Q13268] synonym: "EC 1.1.-.-" EXACT [UniProtKB:Q13268] synonym: "HEP27 protein" EXACT [UniProtKB:Q13268] synonym: "Protein D" EXACT [UniProtKB:Q13268] xref: EMBL:AAA82048.1 xref: EMBL:AAG33703.1 xref: EMBL:AAH07339.2 xref: UniProtKB:Q13268 xref: UniProtKB:Q9H2R2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004468 ! DHRS2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction [Term] id: CCO:B0005758 name: RS7_HUMAN def: "40S ribosomal protein S7" [UniProtKB:P62081] xref: EMBL:AAB00969.1 xref: EMBL:AAH02866.1 xref: EMBL:AAH61901.1 xref: EMBL:AAH71919.1 xref: EMBL:CAA81022.1 xref: UniProtKB:P23821 xref: UniProtKB:P24818 xref: UniProtKB:P62081 xref: UniProtKB:Q6IPH1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005538 ! RPS7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013943 ! RS7_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0005759 name: MLRM_HUMAN def: "Myosin regulatory light chain 2, nonsarcomeric" [UniProtKB:P19105] synonym: "Myosin RLC" EXACT [UniProtKB:P19105] xref: EMBL:AAH16372.1 xref: EMBL:AAH31972.1 xref: EMBL:AAH32748.1 xref: EMBL:CAA38201.1 xref: UniProtKB:P19105 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005104 ! MRLC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0012961 ! MLRM_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0012962 ! MLRM_HUMAN-Phosphothreonine18 relationship: transforms_into CCO:B0012963 ! MLRM_HUMAN-Phosphoserine19 [Term] id: CCO:B0005760 name: NEP_HUMAN def: "Neprilysin" [UniProtKB:P08473] synonym: "Atriopeptidase" EXACT [UniProtKB:P08473] synonym: "CALLA" EXACT [UniProtKB:P08473] synonym: "CD10 antigen" EXACT [UniProtKB:P08473] synonym: "Common acute lymphocytic leukemia antigen" EXACT [UniProtKB:P08473] synonym: "EC 3.4.24.11" EXACT [UniProtKB:P08473] synonym: "Enkephalinase" EXACT [UniProtKB:P08473] synonym: "NEP" EXACT [UniProtKB:P08473] synonym: "Neutral endopeptidase" EXACT [UniProtKB:P08473] synonym: "Neutral endopeptidase 24.11" EXACT [UniProtKB:P08473] xref: EMBL:AAA51915.1 xref: EMBL:AAA52294.1 xref: EMBL:AAI01633.1 xref: EMBL:AAI01659.1 xref: EMBL:CAA30157.1 xref: EMBL:CAA68752.1 xref: UniProtKB:P08473 xref: UniProtKB:Q3MIX4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005185 ! MME_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction [Term] id: CCO:B0005761 name: RL7A_HUMAN def: "60S ribosomal protein L7a" [UniProtKB:P62424] synonym: "PLA-X polypeptide" EXACT [UniProtKB:P62424] synonym: "Surfeit locus protein 3" EXACT [UniProtKB:P62424] xref: EMBL:AAA60282.1 xref: EMBL:AAH05128.1 xref: EMBL:AAH21979.1 xref: EMBL:AAH23594.1 xref: EMBL:AAH23624.1 xref: EMBL:AAH71900.1 xref: EMBL:AAH71901.1 xref: EMBL:AAH73802.1 xref: EMBL:CAA29889.1 xref: EMBL:CAA36383.1 xref: EMBL:CAA43925.1 xref: UniProtKB:P11518 xref: UniProtKB:P62424 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005508 ! RPL7A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction [Term] id: CCO:B0005762 name: RLA0_HUMAN def: "60S acidic ribosomal protein P0" [UniProtKB:P05388] synonym: "L10E" EXACT [UniProtKB:P05388] xref: EMBL:AAA36470.1 xref: EMBL:AAC05176.1 xref: EMBL:AAH00087.1 xref: EMBL:AAH00345.1 xref: EMBL:AAH00752.1 xref: EMBL:AAH01127.1 xref: EMBL:AAH01834.1 xref: EMBL:AAH03655.1 xref: EMBL:AAH05863.1 xref: EMBL:AAH08092.1 xref: EMBL:AAH08594.1 xref: EMBL:AAH09867.1 xref: EMBL:AAH15173.1 xref: EMBL:AAH15690.1 xref: EMBL:BAA25845.1 xref: UniProtKB:P05388 xref: UniProtKB:Q9BVK4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005511 ! RPLP0_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0013896 ! RLA0_HUMAN-Phosphotyrosine24 relationship: transforms_into CCO:B0013897 ! RLA0_HUMAN-Phosphoserine304 relationship: transforms_into CCO:B0013898 ! RLA0_HUMAN-Phosphoserine307 [Term] id: CCO:B0005763 name: RS18_HUMAN def: "40S ribosomal protein S18" [UniProtKB:P62269] synonym: "Ke-3" EXACT [UniProtKB:P62269] synonym: "Ke3" EXACT [UniProtKB:P62269] xref: EMBL:CAA20231.1 xref: EMBL:CAB56794.1 xref: UniProtKB:P25232 xref: UniProtKB:P62269 xref: UniProtKB:Q6IPF8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005532 ! RPS18_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013938 ! RS18_HUMAN-N-acetylserine2 [Term] id: CCO:B0005765 name: VDAC1_HUMAN def: "Voltage-dependent anion-selective channel protein 1" [UniProtKB:P21796] synonym: "hVDAC1" EXACT [UniProtKB:P21796] synonym: "Outer mitochondrial membrane protein porin 1" EXACT [UniProtKB:P21796] synonym: "Plasmalemmal porin" EXACT [UniProtKB:P21796] synonym: "Porin 31HL" EXACT [UniProtKB:P21796] synonym: "Porin 31HM" EXACT [UniProtKB:P21796] synonym: "VDAC-1" EXACT [UniProtKB:P21796] xref: EMBL:AAA61272.1 xref: EMBL:AAC24723.1 xref: EMBL:AAD54939.1 xref: EMBL:AAH08482.1 xref: EMBL:AAH71168.1 xref: EMBL:AAH90042.1 xref: EMBL:CAB58127.1 xref: UniProtKB:P21796 xref: UniProtKB:Q5FVE7 xref: UniProtKB:Q9UIQ5 xref: UniProtKB:Q9UPL0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005894 ! VDAC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0014592 ! VDAC1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0014593 ! VDAC1_HUMAN-Phosphoserine13 relationship: transforms_into CCO:B0014594 ! VDAC1_HUMAN-N6-acetyllysine20 relationship: transforms_into CCO:B0014595 ! VDAC1_HUMAN-N6-acetyllysine28 relationship: transforms_into CCO:B0014596 ! VDAC1_HUMAN-N6-acetyllysine61 relationship: transforms_into CCO:B0014597 ! VDAC1_HUMAN-Phosphoserine104 relationship: transforms_into CCO:B0014598 ! VDAC1_HUMAN-Phosphoserine137 relationship: transforms_into CCO:B0014599 ! VDAC1_HUMAN-Phosphotyrosine195 relationship: transforms_into CCO:B0014600 ! VDAC1_HUMAN-N6-acetyllysine224 relationship: transforms_into CCO:B0031381 ! VDAC1_HUMAN-Phosphotyrosine67 [Term] id: CCO:B0005767 name: RS12_HUMAN def: "40S ribosomal protein S12" [UniProtKB:P25398] xref: EMBL:BAA25819.1 xref: EMBL:CAA37582.1 xref: UniProtKB:P25398 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005530 ! RPS12_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013934 ! RS12_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005768 name: RS3A_HUMAN def: "40S ribosomal protein S3a" [UniProtKB:P61247] xref: EMBL:AAA35682.1 xref: EMBL:AAA58487.1 xref: EMBL:AAA60290.1 xref: EMBL:AAH00204.1 xref: EMBL:AAH01708.1 xref: EMBL:AAH04981.1 xref: EMBL:AAH06298.1 xref: EMBL:AAH09219.1 xref: EMBL:AAH09404.1 xref: EMBL:AAH17123.1 xref: EMBL:AAH19072.1 xref: EMBL:AAH30161.1 xref: EMBL:AAH70211.1 xref: EMBL:AAH71916.1 xref: EMBL:BAA25814.1 xref: EMBL:CAA60827.1 xref: UniProtKB:P33443 xref: UniProtKB:P49241 xref: UniProtKB:P61247 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005536 ! RPS3A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013941 ! RS3A_HUMAN-Phosphotyrosine256 relationship: transforms_into CCO:B0013942 ! RS3A_HUMAN-Phosphoserine263 [Term] id: CCO:B0005769 name: SSRP1_HUMAN def: "FACT complex subunit SSRP1" [UniProtKB:Q08945] synonym: "Chromatin-specific transcription elongation factor 80 kDa subunit" EXACT [UniProtKB:Q08945] synonym: "Facilitates chromatin transcription complex subunit SSRP1" EXACT [UniProtKB:Q08945] synonym: "FACT 80 kDa subunit" EXACT [UniProtKB:Q08945] synonym: "FACTp80" EXACT [UniProtKB:Q08945] synonym: "hSSRP1" EXACT [UniProtKB:Q08945] synonym: "Recombination signal sequence recognition protein 1" EXACT [UniProtKB:Q08945] synonym: "Structure-specific recognition protein 1" EXACT [UniProtKB:Q08945] synonym: "T160" EXACT [UniProtKB:Q08945] xref: EMBL:AAA58660.1 xref: EMBL:AAH05116.1 xref: EMBL:AAH91486.1 xref: UniProtKB:Q08945 xref: UniProtKB:Q5BJG8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005676 ! SSRP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0014219 ! SSRP1_HUMAN-Phosphotyrosine311 relationship: transforms_into CCO:B0014220 ! SSRP1_HUMAN-Phosphotyrosine441 relationship: transforms_into CCO:B0014221 ! SSRP1_HUMAN-Phosphoserine444 relationship: transforms_into CCO:B0014222 ! SSRP1_HUMAN-Phosphoserine510 relationship: transforms_into CCO:B0014223 ! SSRP1_HUMAN-Phosphotyrosine554 relationship: transforms_into CCO:B0014224 ! SSRP1_HUMAN-Phosphoserine561 relationship: transforms_into CCO:B0014225 ! SSRP1_HUMAN-Phosphoserine657 relationship: transforms_into CCO:B0014226 ! SSRP1_HUMAN-Phosphoserine667 relationship: transforms_into CCO:B0014227 ! SSRP1_HUMAN-Phosphoserine668 relationship: transforms_into CCO:B0014228 ! SSRP1_HUMAN-Phosphoserine671 relationship: transforms_into CCO:B0014229 ! SSRP1_HUMAN-Phosphoserine672 relationship: transforms_into CCO:B0014230 ! SSRP1_HUMAN-Phosphoserine673 relationship: transforms_into CCO:B0014231 ! SSRP1_HUMAN-Phosphoserine688 relationship: transforms_into CCO:B0041341 ! SSRP1_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005770 name: RLA1_HUMAN def: "60S acidic ribosomal protein P1" [UniProtKB:P05386] xref: EMBL:AAA36471.1 xref: EMBL:AAH03369.1 xref: EMBL:AAH07590.1 xref: EMBL:BAB79474.1 xref: UniProtKB:P05386 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005512 ! RPLP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0008046 ! rplp1-rif1 physical interaction relationship: participates_in CCO:I0008147 ! pfdn1-rplp1 physical interaction relationship: transforms_into CCO:B0013899 ! RLA1_HUMAN-Phosphoserine5 relationship: transforms_into CCO:B0013900 ! RLA1_HUMAN-Phosphotyrosine11 relationship: transforms_into CCO:B0013901 ! RLA1_HUMAN-Phosphoserine12 relationship: transforms_into CCO:B0013902 ! RLA1_HUMAN-Phosphoserine101 relationship: transforms_into CCO:B0013903 ! RLA1_HUMAN-Phosphoserine104 [Term] id: CCO:B0005771 name: H2B1C_HUMAN def: "Histone H2B type 1-C/E/F/G/I" [UniProtKB:P62807] synonym: "H2B.1 A" EXACT [UniProtKB:P62807] synonym: "H2B.a/g/h/k/l" EXACT [UniProtKB:P62807] synonym: "H2B/a" EXACT [UniProtKB:P62807] synonym: "H2B/g" EXACT [UniProtKB:P62807] synonym: "H2B/h" EXACT [UniProtKB:P62807] synonym: "H2B/k" EXACT [UniProtKB:P62807] synonym: "H2B/l" EXACT [UniProtKB:P62807] xref: EMBL:AAA63189.1 xref: EMBL:AAH82232.1 xref: EMBL:AAH96120.1 xref: EMBL:AAH96122.1 xref: EMBL:AAH96123.1 xref: EMBL:AAI01654.1 xref: EMBL:AAI01656.1 xref: EMBL:AAI01749.1 xref: EMBL:AAI01751.1 xref: EMBL:AAI06900.1 xref: EMBL:AAN06686.1 xref: EMBL:AAN06688.1 xref: EMBL:AAN06689.1 xref: EMBL:AAN06690.1 xref: EMBL:AAN06692.1 xref: EMBL:CAB02541.1 xref: EMBL:CAB02542.1 xref: EMBL:CAB02544.1 xref: EMBL:CAB02545.1 xref: EMBL:CAC03411.1 xref: EMBL:CAC03417.1 xref: EMBL:CAC03420.1 xref: EMBL:CAC04130.1 xref: UniProtKB:P02278 xref: UniProtKB:P62807 xref: UniProtKB:Q3B872 xref: UniProtKB:Q4VB69 xref: UniProtKB:Q93078 xref: UniProtKB:Q93080 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004744 ! HIST1H2BC_human relationship: encoded_by CCO:G0004745 ! HIST1H2BE_human relationship: encoded_by CCO:G0004746 ! HIST1H2BF_human relationship: encoded_by CCO:G0004747 ! HIST1H2BG_human relationship: encoded_by CCO:G0004748 ! HIST1H2BI_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0012011 ! H2B1C_HUMAN-N6-acetyllysine6 relationship: transforms_into CCO:B0012012 ! H2B1C_HUMAN-N6-acetyllysine12 relationship: transforms_into CCO:B0012013 ! H2B1C_HUMAN-N6-acetyllysine13 relationship: transforms_into CCO:B0012014 ! H2B1C_HUMAN-Phosphoserine15 relationship: transforms_into CCO:B0012015 ! H2B1C_HUMAN-N6-acetyllysine16 relationship: transforms_into CCO:B0012016 ! H2B1C_HUMAN-N6-acetyllysine17 relationship: transforms_into CCO:B0012017 ! H2B1C_HUMAN-N6-acetyllysine21 relationship: transforms_into CCO:B0012018 ! H2B1C_HUMAN-N6-acetyllysine24 relationship: transforms_into CCO:B0012019 ! H2B1C_HUMAN-N6-methyllysine47 relationship: transforms_into CCO:B0012020 ! H2B1C_HUMAN-N6,N6-dimethyllysine58 relationship: transforms_into CCO:B0012021 ! H2B1C_HUMAN-N6-acetyllysine109 relationship: transforms_into CCO:B0012022 ! H2B1C_HUMAN-N6-methyllysine109 [Term] id: CCO:B0005772 name: TBA1A_HUMAN def: "Tubulin alpha-1A chain" [UniProtKB:Q71U36] synonym: "Alpha-tubulin 3" EXACT [UniProtKB:Q71U36] synonym: "Tubulin alpha-3 chain" EXACT [UniProtKB:Q71U36] synonym: "Tubulin B-alpha-1" EXACT [UniProtKB:Q71U36] xref: EMBL:AAA91575.1 xref: EMBL:AAD33871.1 xref: EMBL:AAH06468.1 xref: EMBL:AAH50637.1 xref: EMBL:CAA25855.1 xref: UniProtKB:P04687 xref: UniProtKB:P05209 xref: UniProtKB:Q71U36 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005730 ! TUBA1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0014308 ! TBA1A_HUMAN-Phosphoserine6 relationship: transforms_into CCO:B0014309 ! TBA1A_HUMAN-Phosphotyrosine272 relationship: transforms_into CCO:B0014310 ! TBA1A_HUMAN-Phosphoserine439 [Term] id: CCO:B0005773 name: DDX3X_HUMAN def: "ATP-dependent RNA helicase DDX3X" [UniProtKB:O00571] synonym: "DEAD box protein 3, X-chromosomal" EXACT [UniProtKB:O00571] synonym: "DEAD box, X isoform" EXACT [UniProtKB:O00571] synonym: "EC 3.6.1.-" EXACT [UniProtKB:O00571] synonym: "Helicase-like protein 2" EXACT [UniProtKB:O00571] synonym: "HLP2" EXACT [UniProtKB:O00571] xref: EMBL:AAB95637.1 xref: EMBL:AAC34298.1 xref: EMBL:AAC51829.1 xref: EMBL:AAC51830.1 xref: EMBL:AAH11819.1 xref: UniProtKB:O00571 xref: UniProtKB:O15536 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004458 ! DDX3X_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0011471 ! DDX3X_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0011472 ! DDX3X_HUMAN-Phosphotyrosine69 relationship: transforms_into CCO:B0011473 ! DDX3X_HUMAN-Phosphoserine74 relationship: transforms_into CCO:B0011474 ! DDX3X_HUMAN-Phosphoserine76 relationship: transforms_into CCO:B0011475 ! DDX3X_HUMAN-Phosphoserine78 relationship: transforms_into CCO:B0011476 ! DDX3X_HUMAN-Phosphotyrosine104 relationship: transforms_into CCO:B0011477 ! DDX3X_HUMAN-Phosphoserine125 relationship: transforms_into CCO:B0011478 ! DDX3X_HUMAN-Phosphotyrosine343 relationship: transforms_into CCO:B0011479 ! DDX3X_HUMAN-Phosphoserine590 relationship: transforms_into CCO:B0011480 ! DDX3X_HUMAN-Phosphoserine594 [Term] id: CCO:B0005774 name: ROA1_HUMAN def: "Heterogeneous nuclear ribonucleoprotein A1" [UniProtKB:P09651] synonym: "Helix-destabilizing protein" EXACT [UniProtKB:P09651] synonym: "hnRNP core protein A1" EXACT [UniProtKB:P09651] synonym: "Single-strand RNA-binding protein" EXACT [UniProtKB:P09651] xref: EMBL:AAH02355.1 xref: EMBL:AAH09600.1 xref: EMBL:AAH12158.1 xref: EMBL:AAH33714.1 xref: EMBL:AAH52296.1 xref: EMBL:AAH70315.1 xref: EMBL:AAH74502.1 xref: EMBL:CAA27874.1 xref: EMBL:CAA29922.1 xref: EMBL:CAA31191.1 xref: EMBL:CAA56072.1 xref: UniProtKB:P09651 xref: UniProtKB:Q6PJZ7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006368 ! HNRNPA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013909 ! ROA1_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0013910 ! ROA1_HUMAN-Phosphoserine4 relationship: transforms_into CCO:B0013911 ! ROA1_HUMAN-Phosphoserine6 relationship: transforms_into CCO:B0013912 ! ROA1_HUMAN-Phosphoserine91 relationship: transforms_into CCO:B0013913 ! ROA1_HUMAN-Phosphoserine95 relationship: transforms_into CCO:B0013914 ! ROA1_HUMAN-Phosphothreonine138 relationship: transforms_into CCO:B0013915 ! ROA1_HUMAN-Phosphotyrosine167 relationship: transforms_into CCO:B0013916 ! ROA1_HUMAN-Omega-N-methylated arginine194 relationship: transforms_into CCO:B0013917 ! ROA1_HUMAN-Omega-N-methylated arginine206 relationship: transforms_into CCO:B0013918 ! ROA1_HUMAN-Omega-N-methylated arginine225 relationship: transforms_into CCO:B0013919 ! ROA1_HUMAN-Phosphoserine311 relationship: transforms_into CCO:B0013920 ! ROA1_HUMAN-Phosphoserine338 relationship: transforms_into CCO:B0013921 ! ROA1_HUMAN-Phosphotyrosine347 relationship: transforms_into CCO:B0013922 ! ROA1_HUMAN-N6-acetyllysine350 [Term] id: CCO:B0005775 name: ACTB_HUMAN def: "Actin, cytoplasmic 1" [UniProtKB:P60709] synonym: "Beta-actin" EXACT [UniProtKB:P60709] xref: EMBL:AAA51567.1 xref: EMBL:AAH01301.1 xref: EMBL:AAH02409.1 xref: EMBL:AAH04251.1 xref: EMBL:AAH13380.1 xref: EMBL:AAH14861.1 xref: EMBL:AAH16045.1 xref: EMBL:AAP22343.1 xref: EMBL:AAS79319.1 xref: EMBL:CAA23745.1 xref: EMBL:CAA25099.1 xref: EMBL:CAA45026.1 xref: UniProtKB:P02570 xref: UniProtKB:P60709 xref: UniProtKB:P70514 xref: UniProtKB:P99021 xref: UniProtKB:Q11211 xref: UniProtKB:Q64316 xref: UniProtKB:Q75MN2 xref: UniProtKB:Q96B34 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004020 ! ACTB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0010440 ! ACTB_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0010441 ! ACTB_HUMAN-N-acetylaspartate2 relationship: transforms_into CCO:B0010442 ! ACTB_HUMAN-Tele-methylhistidine73 relationship: transforms_into CCO:B0010443 ! ACTB_HUMAN-Phosphotyrosine166 relationship: transforms_into CCO:B0010444 ! ACTB_HUMAN-Phosphotyrosine218 relationship: transforms_into CCO:B0010445 ! ACTB_HUMAN-Phosphotyrosine294 relationship: transforms_into CCO:B0041109 ! ACTB_HUMAN-Phosphothreonine318 [Term] id: CCO:B0005776 name: RSSA_HUMAN def: "40S ribosomal protein SA" [UniProtKB:P08865] synonym: "34/67 kDa laminin receptor" EXACT [UniProtKB:P08865] synonym: "Colon carcinoma laminin-binding protein" EXACT [UniProtKB:P08865] synonym: "Laminin receptor 1" EXACT [UniProtKB:P08865] synonym: "LamR" EXACT [UniProtKB:P08865] synonym: "Multidrug resistance-associated protein MGr1-Ag" EXACT [UniProtKB:P08865] synonym: "NEM/1CHD4" EXACT [UniProtKB:P08865] synonym: "p40" EXACT [UniProtKB:P08865] xref: EMBL:AAA36161.1 xref: EMBL:AAA36165.1 xref: EMBL:AAB22299.1 xref: EMBL:AAC50313.1 xref: EMBL:AAC50652.1 xref: EMBL:AAH05391.1 xref: EMBL:AAH08867.1 xref: EMBL:AAH10418.1 xref: EMBL:AAH13827.1 xref: EMBL:AAH34537.1 xref: EMBL:AAH50688.1 xref: EMBL:AAH53370.1 xref: EMBL:AAH62714.1 xref: EMBL:AAH66941.1 xref: EMBL:AAH68062.1 xref: EMBL:AAH70263.1 xref: EMBL:AAH71693.1 xref: EMBL:AAH71968.1 xref: EMBL:AAH71969.1 xref: EMBL:AAH71970.1 xref: EMBL:AAH71971.1 xref: EMBL:AAH73863.1 xref: EMBL:AAI07568.1 xref: EMBL:AAM33304.1 xref: EMBL:AAP35883.1 xref: EMBL:BAA25812.1 xref: EMBL:CAA33112.1 xref: EMBL:CAA43469.1 xref: UniProtKB:P08865 xref: UniProtKB:P11085 xref: UniProtKB:P12030 xref: UniProtKB:Q16471 xref: UniProtKB:Q6IPD1 xref: UniProtKB:Q6IPD2 xref: UniProtKB:Q6NSD1 xref: UniProtKB:Q6NXQ8 xref: UniProtKB:Q86VC0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005543 ! RPSA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0013945 ! RSSA_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0013946 ! RSSA_HUMAN-Phosphotyrosine139 [Term] id: CCO:B0005777 name: VDAC2_HUMAN def: "Voltage-dependent anion-selective channel protein 2" [UniProtKB:P45880] synonym: "hVDAC2" EXACT [UniProtKB:P45880] synonym: "Outer mitochondrial membrane protein porin 2" EXACT [UniProtKB:P45880] synonym: "VDAC-2" EXACT [UniProtKB:P45880] xref: EMBL:AAA60144.1 xref: EMBL:AAA60145.1 xref: EMBL:AAB59457.1 xref: EMBL:AAD40241.1 xref: EMBL:AAH00165.2 xref: EMBL:AAH12883.2 xref: EMBL:AAH72407.1 xref: EMBL:CAG33245.1 xref: EMBL:CAH73106.1 xref: EMBL:CAH73107.1 xref: EMBL:CAH73108.1 xref: EMBL:CAI40910.1 xref: EMBL:CAI40911.1 xref: EMBL:CAI40914.1 xref: UniProtKB:P45880 xref: UniProtKB:Q5VWK1 xref: UniProtKB:Q5VWK3 xref: UniProtKB:Q6IB40 xref: UniProtKB:Q7L3J5 xref: UniProtKB:Q9BWK8 xref: UniProtKB:Q9Y5I6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005895 ! VDAC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0014601 ! VDAC2_HUMAN-N6-acetyllysine31 relationship: transforms_into CCO:B0014602 ! VDAC2_HUMAN-N6-acetyllysine74 relationship: transforms_into CCO:B0014603 ! VDAC2_HUMAN-Phosphoserine115 relationship: transforms_into CCO:B0014604 ! VDAC2_HUMAN-Phosphotyrosine236 relationship: transforms_into CCO:B0031382 ! VDAC2_HUMAN-Phosphotyrosine206 [Term] id: CCO:B0005778 name: ATPA_HUMAN def: "ATP synthase subunit alpha, mitochondrial precursor" [UniProtKB:P25705] xref: EMBL:AAH03119.1 xref: EMBL:AAH07299.1 xref: EMBL:AAH08028.2 xref: EMBL:AAH11384.1 xref: EMBL:AAH16046.1 xref: EMBL:AAH19310.1 xref: EMBL:AAH39135.2 xref: EMBL:AAH64562.1 xref: EMBL:AAH67385.1 xref: EMBL:AAP35873.1 xref: EMBL:BAA03531.1 xref: EMBL:BAA05672.1 xref: EMBL:CAA41789.1 xref: EMBL:CAA46452.1 xref: UniProtKB:P25705 xref: UniProtKB:Q53XX6 xref: UniProtKB:Q8IXV2 xref: UniProtKB:Q96FB4 xref: UniProtKB:Q96HW2 xref: UniProtKB:Q96IR6 xref: UniProtKB:Q9BTV8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004119 ! ATP5A1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0010676 ! ATPA_HUMAN-Pyrrolidone carboxylic acid44 relationship: transforms_into CCO:B0010677 ! ATPA_HUMAN-Phosphoserine76 relationship: transforms_into CCO:B0010678 ! ATPA_HUMAN-N6-acetyllysine132 relationship: transforms_into CCO:B0010679 ! ATPA_HUMAN-N6-acetyllysine230 relationship: transforms_into CCO:B0010680 ! ATPA_HUMAN-N6-acetyllysine239 relationship: transforms_into CCO:B0010681 ! ATPA_HUMAN-N6-acetyllysine261 relationship: transforms_into CCO:B0010682 ! ATPA_HUMAN-N6-acetyllysine305 relationship: transforms_into CCO:B0010683 ! ATPA_HUMAN-N6-acetyllysine427 relationship: transforms_into CCO:B0010684 ! ATPA_HUMAN-N6-acetyllysine498 relationship: transforms_into CCO:B0010685 ! ATPA_HUMAN-N6-acetyllysine531 relationship: transforms_into CCO:B0010686 ! ATPA_HUMAN-N6-acetyllysine539 [Term] id: CCO:B0005779 name: ENOA_HUMAN def: "Alpha-enolase" [UniProtKB:P06733] synonym: "2-phospho-D-glycerate hydro-lyase" EXACT [UniProtKB:P06733] synonym: "C-myc promoter-binding protein" EXACT [UniProtKB:P06733] synonym: "EC 4.2.1.11" EXACT [UniProtKB:P06733] synonym: "Enolase 1" EXACT [UniProtKB:P06733] synonym: "MBP-1" EXACT [UniProtKB:P06733] synonym: "MPB-1" EXACT [UniProtKB:P06733] synonym: "NNE" EXACT [UniProtKB:P06733] synonym: "Non-neural enolase" EXACT [UniProtKB:P06733] synonym: "Phosphopyruvate hydratase" EXACT [UniProtKB:P06733] synonym: "Plasminogen-binding protein" EXACT [UniProtKB:P06733] xref: EMBL:AAA35698.1 xref: EMBL:AAA52387.1 xref: EMBL:AAB88178.1 xref: EMBL:AAC39935.1 xref: EMBL:AAH01810.1 xref: EMBL:AAH04458.1 xref: EMBL:AAH09912.1 xref: EMBL:AAH11130.1 xref: EMBL:AAH15641.1 xref: EMBL:AAH21166.2 xref: EMBL:AAH22545.1 xref: EMBL:AAH27725.1 xref: EMBL:AAH50642.1 xref: EMBL:AAP35827.1 xref: EMBL:AAY43128.1 xref: EMBL:CAA34360.1 xref: EMBL:CAA59331.1 xref: EMBL:CAC42425.1 xref: EMBL:CAD97642.1 xref: EMBL:CAH56247.1 xref: UniProtKB:P06733 xref: UniProtKB:P22712 xref: UniProtKB:Q16704 xref: UniProtKB:Q4TUS4 xref: UniProtKB:Q658M5 xref: UniProtKB:Q6GMP2 xref: UniProtKB:Q71V37 xref: UniProtKB:Q7Z3V6 xref: UniProtKB:Q8WU71 xref: UniProtKB:Q9UM55 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004565 ! ENO1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0011687 ! ENOA_HUMAN-Phosphotyrosine44 relationship: transforms_into CCO:B0011688 ! ENOA_HUMAN-Phosphotyrosine57 relationship: transforms_into CCO:B0011689 ! ENOA_HUMAN-Phosphoserine63 relationship: transforms_into CCO:B0011690 ! ENOA_HUMAN-N6-acetyllysine71 relationship: transforms_into CCO:B0011691 ! ENOA_HUMAN-Phosphothreonine72 relationship: transforms_into CCO:B0011692 ! ENOA_HUMAN-Phosphoserine263 relationship: transforms_into CCO:B0011693 ! ENOA_HUMAN-Phosphotyrosine287 [Term] id: CCO:B0005784 name: MED31_HUMAN def: "Mediator of RNA polymerase II transcription subunit 31" [UniProtKB:Q9Y3C7] synonym: "hSOH1" EXACT [UniProtKB:Q9Y3C7] synonym: "Mediator complex subunit 31" EXACT [UniProtKB:Q9Y3C7] synonym: "Mediator complex subunit SOH1" EXACT [UniProtKB:Q9Y3C7] xref: EMBL:AAD34120.1 xref: EMBL:AAH12539.1 xref: UniProtKB:Q9Y3C7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005074 ! MED31_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008056 ! supt5h-med31 physical interaction relationship: participates_in CCO:I0008092 ! dleu1-med31 physical interaction relationship: participates_in CCO:I0008142 ! pfdn1-med31 physical interaction relationship: participates_in CCO:I0008235 ! smpd3-med31 physical interaction relationship: participates_in CCO:I0008291 ! pmf1-med31 physical interaction [Term] id: CCO:B0005793 name: MED23_HUMAN def: "Mediator of RNA polymerase II transcription subunit 23" [UniProtKB:Q9ULK4] synonym: "Activator-recruited cofactor 130 kDa component" EXACT [UniProtKB:Q9ULK4] synonym: "ARC130" EXACT [UniProtKB:Q9ULK4] synonym: "Cofactor required for Sp1 transcriptional activation subunit 3" EXACT [UniProtKB:Q9ULK4] synonym: "CRSP complex subunit 3" EXACT [UniProtKB:Q9ULK4] synonym: "DRIP130" EXACT [UniProtKB:Q9ULK4] synonym: "hSur-2" EXACT [UniProtKB:Q9ULK4] synonym: "Mediator complex subunit 23" EXACT [UniProtKB:Q9ULK4] synonym: "Transcriptional coactivator CRSP130" EXACT [UniProtKB:Q9ULK4] synonym: "Vitamin D3 receptor-interacting protein complex 130 kDa component" EXACT [UniProtKB:Q9ULK4] xref: EMBL:AAD12724.1 xref: EMBL:AAD30202.1 xref: EMBL:AAD31729.1 xref: EMBL:AAH60759.1 xref: EMBL:BAA86530.1 xref: EMBL:CAB66710.1 xref: EMBL:CAB92072.1 xref: EMBL:CAB92073.1 xref: EMBL:CAI23319.1 xref: EMBL:CAI23320.1 xref: EMBL:EAW48052.1 xref: UniProtKB:O95403 xref: UniProtKB:Q5JWT3 xref: UniProtKB:Q5JWT4 xref: UniProtKB:Q6P9H6 xref: UniProtKB:Q9H0J2 xref: UniProtKB:Q9NTT9 xref: UniProtKB:Q9NTU0 xref: UniProtKB:Q9ULK4 xref: UniProtKB:Q9Y5P7 xref: UniProtKB:Q9Y667 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005067 ! MED23_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0005806 name: OGT1_HUMAN def: "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit" [UniProtKB:O15294] synonym: "EC 2.4.1.-" EXACT [UniProtKB:O15294] synonym: "O-GlcNAc transferase subunit p110" EXACT [UniProtKB:O15294] synonym: "O-linked N-acetylglucosamine transferase 110 kDa subunit" EXACT [UniProtKB:O15294] xref: EMBL:AAB63466.1 xref: EMBL:AAH14434.1 xref: EMBL:AAH38180.1 xref: EMBL:CAB62528.1 xref: EMBL:CAC86127.1 xref: EMBL:CAC86128.1 xref: EMBL:CAC86129.1 xref: EMBL:CAD89970.1 xref: EMBL:CAD97853.1 xref: UniProtKB:O15294 xref: UniProtKB:Q7Z3K0 xref: UniProtKB:Q8WWM8 xref: UniProtKB:Q96CC1 xref: UniProtKB:Q9UG57 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005230 ! OGT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007094 ! hcfc1-ogt-1 physical interaction relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: transforms_into CCO:B0041168 ! OGT1_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005807 name: SIN3B_HUMAN def: "Paired amphipathic helix protein Sin3b" [UniProtKB:O75182] synonym: "Histone deacetylase complex subunit Sin3b" EXACT [UniProtKB:O75182] synonym: "Transcriptional corepressor Sin3b" EXACT [UniProtKB:O75182] xref: EMBL:AAH05113.1 xref: EMBL:AAH25026.1 xref: EMBL:AAH63531.1 xref: EMBL:AAU01916.1 xref: EMBL:BAA31675.2 xref: UniProtKB:O75182 xref: UniProtKB:Q68GC2 xref: UniProtKB:Q6P4B8 xref: UniProtKB:Q8TB34 xref: UniProtKB:Q9BSC8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005615 ! SIN3B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007096 ! hcfc1-sin3b-1 physical interaction [Term] id: CCO:B0005808 name: THIO_HUMAN def: "Thioredoxin" [UniProtKB:P10599] synonym: "ADF" EXACT [UniProtKB:P10599] synonym: "ATL-derived factor" EXACT [UniProtKB:P10599] synonym: "SASP" EXACT [UniProtKB:P10599] synonym: "Surface-associated sulphydryl protein" EXACT [UniProtKB:P10599] synonym: "Trx" EXACT [UniProtKB:P10599] xref: EMBL:AAA74596.1 xref: EMBL:AAF86466.1 xref: EMBL:AAF87085.1 xref: EMBL:AAG34699.1 xref: EMBL:AAH03377.1 xref: EMBL:AAH54866.1 xref: EMBL:AAN33187.1 xref: EMBL:CAA38410.1 xref: EMBL:CAA54687.1 xref: UniProtKB:P10599 xref: UniProtKB:Q96KI3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005779 ! TXN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0014350 ! THIO_HUMAN-N6-acetyllysine94 relationship: transforms_into CCO:B0014351 ! THIO_HUMAN-Phosphothreonine100 [Term] id: CCO:B0005809 name: RBBP7_HUMAN def: "Histone-binding protein RBBP7" [UniProtKB:Q16576] synonym: "Histone acetyltransferase type B subunit 2" EXACT [UniProtKB:Q16576] synonym: "Nucleosome-remodeling factor subunit RBAP46" EXACT [UniProtKB:Q16576] synonym: "RBBP-7" EXACT [UniProtKB:Q16576] synonym: "Retinoblastoma-binding protein 7" EXACT [UniProtKB:Q16576] synonym: "Retinoblastoma-binding protein p46" EXACT [UniProtKB:Q16576] xref: EMBL:AAC50231.1 xref: EMBL:CAA51360.1 xref: UniProtKB:Q16576 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005441 ! RBBP7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007121 ! hcfc1-many-1 physical interaction relationship: transforms_into CCO:B0013744 ! RBBP7_HUMAN-N6-acetyllysine119 relationship: transforms_into CCO:B0013745 ! RBBP7_HUMAN-Phosphoserine413 relationship: transforms_into CCO:B0013746 ! RBBP7_HUMAN-Phosphothreonine416 [Term] id: CCO:B0005810 name: ACTA_HUMAN def: "Actin, aortic smooth muscle" [UniProtKB:P62736] synonym: "Alpha-actin-2" EXACT [UniProtKB:P62736] synonym: "Cell growth-inhibiting gene 46 protein" EXACT [UniProtKB:P62736] xref: EMBL:AAA51577.1 xref: EMBL:AAA60560.1 xref: EMBL:AAH17554.1 xref: EMBL:AAH93052.1 xref: EMBL:AAW29811.1 xref: EMBL:CAA32064.1 xref: EMBL:CAG38756.1 xref: EMBL:CAI13864.1 xref: UniProtKB:P03996 xref: UniProtKB:P04108 xref: UniProtKB:P62736 xref: UniProtKB:Q6FI19 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004019 ! ACTA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007125 ! actn2-ttn-6 physical interaction relationship: transforms_into CCO:B0010437 ! ACTA_HUMAN-N-acetylglutamate3 relationship: transforms_into CCO:B0010438 ! ACTA_HUMAN-Tele-methylhistidine75 relationship: transforms_into CCO:B0010439 ! ACTA_HUMAN-Nitrated tyrosine296 [Term] id: CCO:B0005811 name: K2C5_HUMAN def: "Keratin, type II cytoskeletal 5" [UniProtKB:P13647] synonym: "58 kDa cytokeratin" EXACT [UniProtKB:P13647] synonym: "CK-5" EXACT [UniProtKB:P13647] synonym: "Cytokeratin-5" EXACT [UniProtKB:P13647] synonym: "K5" EXACT [UniProtKB:P13647] synonym: "Keratin-5" EXACT [UniProtKB:P13647] xref: EMBL:AAA36143.1 xref: EMBL:AAA36145.1 xref: EMBL:AAF97931.1 xref: EMBL:AAH24292.1 xref: EMBL:AAH42132.1 xref: EMBL:AAH71906.1 xref: EMBL:AAQ81588.1 xref: UniProtKB:P13647 xref: UniProtKB:Q6PI71 xref: UniProtKB:Q6UBJ0 xref: UniProtKB:Q8TA91 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004926 ! KRT5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0012479 ! K2C5_HUMAN-Phosphoserine64 [Term] id: CCO:B0005812 name: FAK1_HUMAN def: "Focal adhesion kinase 1" [UniProtKB:Q05397] synonym: "EC 2.7.10.2" EXACT [UniProtKB:Q05397] synonym: "FADK 1" EXACT [UniProtKB:Q05397] synonym: "pp125FAK" EXACT [UniProtKB:Q05397] synonym: "Protein-tyrosine kinase 2" EXACT [UniProtKB:Q05397] xref: EMBL:AAA35819.1 xref: EMBL:AAA58469.1 xref: UniProtKB:Q05397 xref: UniProtKB:Q14291 xref: UniProtKB:Q9UD85 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004606 ! PTK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0011824 ! FAK1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0011825 ! FAK1_HUMAN-Phosphotyrosine397 relationship: transforms_into CCO:B0011826 ! FAK1_HUMAN-Phosphotyrosine407 relationship: transforms_into CCO:B0011827 ! FAK1_HUMAN-Phosphotyrosine576 relationship: transforms_into CCO:B0011828 ! FAK1_HUMAN-Phosphotyrosine577 relationship: transforms_into CCO:B0011829 ! FAK1_HUMAN-Phosphoserine722 relationship: transforms_into CCO:B0011830 ! FAK1_HUMAN-Phosphoserine840 relationship: transforms_into CCO:B0011831 ! FAK1_HUMAN-Phosphoserine843 relationship: transforms_into CCO:B0011832 ! FAK1_HUMAN-Phosphotyrosine861 relationship: transforms_into CCO:B0011833 ! FAK1_HUMAN-Phosphoserine910 relationship: transforms_into CCO:B0011834 ! FAK1_HUMAN-Phosphotyrosine925 [Term] id: CCO:B0005813 name: ADT2_HUMAN def: "ADP/ATP translocase 2" [UniProtKB:P05141] synonym: "Adenine nucleotide translocator 2" EXACT [UniProtKB:P05141] synonym: "ADP,ATP carrier protein 2" EXACT [UniProtKB:P05141] synonym: "ADP,ATP carrier protein, fibroblast isoform" EXACT [UniProtKB:P05141] synonym: "ANT 2" EXACT [UniProtKB:P05141] synonym: "Solute carrier family 25 member 5" EXACT [UniProtKB:P05141] xref: EMBL:AAA35579.1 xref: EMBL:AAA36749.1 xref: EMBL:AAA51737.1 xref: EMBL:AAB39266.1 xref: EMBL:AAB96347.1 xref: EMBL:AAH56160.1 xref: UniProtKB:O43350 xref: UniProtKB:P05141 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004032 ! SLC25A5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0010460 ! ADT2_HUMAN-N-acetylthreonine2 relationship: transforms_into CCO:B0010461 ! ADT2_HUMAN-N6-acetyllysine23 relationship: transforms_into CCO:B0010462 ! ADT2_HUMAN-Phosphoserine42 relationship: transforms_into CCO:B0010463 ! ADT2_HUMAN-N6-acetyllysine92 relationship: transforms_into CCO:B0010464 ! ADT2_HUMAN-N6-acetyllysine163 relationship: transforms_into CCO:B0010465 ! ADT2_HUMAN-N6-acetyllysine166 relationship: transforms_into CCO:B0010466 ! ADT2_HUMAN-N6-acetyllysine199 relationship: transforms_into CCO:B0031287 ! ADT2_HUMAN-Phosphotyrosine191 relationship: transforms_into CCO:B0031288 ! ADT2_HUMAN-Phosphotyrosine195 [Term] id: CCO:B0005814 name: HNRPF_HUMAN def: "Heterogeneous nuclear ribonucleoprotein F" [UniProtKB:P52597] synonym: "hnRNP F" EXACT [UniProtKB:P52597] synonym: "Nucleolin-like protein mcs94-1" EXACT [UniProtKB:P52597] xref: EMBL:AAC37584.1 xref: EMBL:AAH01432.1 xref: EMBL:AAH04254.1 xref: EMBL:AAH15580.1 xref: EMBL:AAH16736.1 xref: EMBL:AAI06009.1 xref: EMBL:CAI17066.1 xref: UniProtKB:P52597 xref: UniProtKB:Q5T0N2 xref: UniProtKB:Q96AU2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004819 ! HNRPF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0012230 ! HNRPF_HUMAN-N-acetylmethionine2 relationship: transforms_into CCO:B0012231 ! HNRPF_HUMAN-Phosphoserine161 relationship: transforms_into CCO:B0012232 ! HNRPF_HUMAN-Phosphotyrosine246 relationship: transforms_into CCO:B0012233 ! HNRPF_HUMAN-Phosphoserine310 [Term] id: CCO:B0005815 name: EFNB1_HUMAN def: "Ephrin-B1 precursor" [UniProtKB:P98172] synonym: "ELK ligand" EXACT [UniProtKB:P98172] synonym: "ELK-L" EXACT [UniProtKB:P98172] synonym: "EPH-related receptor tyrosine kinase ligand 2" EXACT [UniProtKB:P98172] synonym: "LERK-2" EXACT [UniProtKB:P98172] xref: EMBL:AAA52369.1 xref: EMBL:AAA53093.1 xref: EMBL:AAB41127.1 xref: EMBL:AAH16649.1 xref: EMBL:AAH52979.1 xref: EMBL:CAB86409.1 xref: UniProtKB:P98172 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004549 ! EFNB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0011650 ! EFNB1_HUMAN-Phosphoserine287 [Term] id: CCO:B0005816 name: ATX10_HUMAN def: "Ataxin-10" [UniProtKB:Q9UBB4] synonym: "Brain protein E46 homolog" EXACT [UniProtKB:Q9UBB4] synonym: "Spinocerebellar ataxia type 10 protein" EXACT [UniProtKB:Q9UBB4] xref: EMBL:AAF17219.1 xref: EMBL:AAH07508.1 xref: EMBL:CAB43383.1 xref: EMBL:CAG30454.1 xref: EMBL:CAG33662.1 xref: EMBL:CAI20373.1 xref: EMBL:CAI20419.1 xref: EMBL:CAI41716.1 xref: UniProtKB:O14998 xref: UniProtKB:O15009 xref: UniProtKB:Q6I9X4 xref: UniProtKB:Q9UBB4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004125 ! ATXN10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction [Term] id: CCO:B0005817 name: K1C14_HUMAN def: "Keratin, type I cytoskeletal 14" [UniProtKB:P02533] synonym: "CK-14" EXACT [UniProtKB:P02533] synonym: "Cytokeratin-14" EXACT [UniProtKB:P02533] synonym: "K14" EXACT [UniProtKB:P02533] synonym: "Keratin-14" EXACT [UniProtKB:P02533] xref: EMBL:AAB59562.1 xref: EMBL:AAF04034.1 xref: EMBL:AAF04035.1 xref: EMBL:AAF04036.1 xref: EMBL:AAF04037.1 xref: EMBL:AAF04038.1 xref: EMBL:AAF04039.1 xref: EMBL:AAH02690.1 xref: EMBL:AAH19097.1 xref: EMBL:AAH42437.1 xref: EMBL:AAH94830.1 xref: EMBL:AAP35850.1 xref: EMBL:BAA05967.1 xref: UniProtKB:P02533 xref: UniProtKB:Q14715 xref: UniProtKB:Q53XY3 xref: UniProtKB:Q9BUE3 xref: UniProtKB:Q9UBN2 xref: UniProtKB:Q9UBN3 xref: UniProtKB:Q9UCY4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004920 ! KRT14_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction [Term] id: CCO:B0005818 name: DNJA3_HUMAN def: "DnaJ homolog subfamily A member 3, mitochondrial precursor" [UniProtKB:Q96EY1] synonym: "DnaJ protein Tid-1" EXACT [UniProtKB:Q96EY1] synonym: "Hepatocellular carcinoma-associated antigen 57" EXACT [UniProtKB:Q96EY1] synonym: "hTid-1" EXACT [UniProtKB:Q96EY1] synonym: "Tumorous imaginal discs protein Tid56 homolog" EXACT [UniProtKB:Q96EY1] xref: EMBL:AAC29066.1 xref: EMBL:AAF66245.1 xref: EMBL:AAH07225.1 xref: EMBL:AAH11855.1 xref: EMBL:AAH12343.1 xref: EMBL:AAH14062.1 xref: EMBL:AAH20248.1 xref: EMBL:AAH30145.1 xref: EMBL:AAH32100.1 xref: EMBL:AAL35323.1 xref: UniProtKB:O75472 xref: UniProtKB:Q8WUJ6 xref: UniProtKB:Q8WXJ3 xref: UniProtKB:Q96D76 xref: UniProtKB:Q96EY1 xref: UniProtKB:Q96IV1 xref: UniProtKB:Q9NYH8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004489 ! DNAJA3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007685 ! gfi1b-dnaja3 physical interaction relationship: transforms_into CCO:B0011551 ! DNJA3_HUMAN-Phosphoserine169 [Term] id: CCO:B0005819 name: CBLB_HUMAN def: "E3 ubiquitin-protein ligase CBL-B" [UniProtKB:Q13191] synonym: "Casitas B-lineage lymphoma proto-oncogene b" EXACT [UniProtKB:Q13191] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q13191] synonym: "RING finger protein 56" EXACT [UniProtKB:Q13191] synonym: "SH3-binding protein CBL-B" EXACT [UniProtKB:Q13191] synonym: "Signal transduction protein CBL-B" EXACT [UniProtKB:Q13191] xref: EMBL:AAB09291.1 xref: EMBL:AAB09292.1 xref: EMBL:AAB09293.1 xref: EMBL:AAH32851.1 xref: EMBL:BAE45748.1 xref: EMBL:CAH56175.1 xref: UniProtKB:Q13191 xref: UniProtKB:Q13192 xref: UniProtKB:Q13193 xref: UniProtKB:Q3LIC0 xref: UniProtKB:Q63Z43 xref: UniProtKB:Q8IVC5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004227 ! CBLB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0010939 ! CBLB_HUMAN-Phosphoserine480 relationship: transforms_into CCO:B0010940 ! CBLB_HUMAN-Phosphoserine484 relationship: transforms_into CCO:B0010941 ! CBLB_HUMAN-Phosphotyrosine665 relationship: transforms_into CCO:B0010942 ! CBLB_HUMAN-Phosphotyrosine709 relationship: transforms_into CCO:B0010943 ! CBLB_HUMAN-Phosphotyrosine889 [Term] id: CCO:B0005820 name: PEX19_HUMAN def: "Peroxisomal biogenesis factor 19" [UniProtKB:P40855] synonym: "33 kDa housekeeping protein" EXACT [UniProtKB:P40855] synonym: "Peroxin-19" EXACT [UniProtKB:P40855] synonym: "Peroxisomal farnesylated protein" EXACT [UniProtKB:P40855] xref: EMBL:AAH00496.1 xref: EMBL:AAP35525.1 xref: EMBL:BAA76291.1 xref: EMBL:BAB93469.1 xref: EMBL:CAA53225.1 xref: EMBL:CAA70257.1 xref: UniProtKB:P40855 xref: UniProtKB:Q8NI97 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005299 ! PEX19_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0013487 ! PEX19_HUMAN-Phosphoserine35 relationship: transforms_into CCO:B0013488 ! PEX19_HUMAN-Phosphoserine54 relationship: transforms_into CCO:B0013489 ! PEX19_HUMAN-Phosphoserine146 relationship: transforms_into CCO:B0013490 ! PEX19_HUMAN-Phosphoserine147 relationship: transforms_into CCO:B0013491 ! PEX19_HUMAN-Phosphoserine149 relationship: transforms_into CCO:B0013492 ! PEX19_HUMAN-Phosphoserine177 relationship: transforms_into CCO:B0013493 ! PEX19_HUMAN-Phosphoserine184 [Term] id: CCO:B0005821 name: K2C6A_HUMAN def: "Keratin, type II cytoskeletal 6A" [UniProtKB:P02538] synonym: "Allergen Hom s 5" EXACT [UniProtKB:P02538] synonym: "CK 6A" EXACT [UniProtKB:P02538] synonym: "CK 6D" EXACT [UniProtKB:P02538] synonym: "Cytokeratin-6A" EXACT [UniProtKB:P02538] synonym: "Cytokeratin-6D" EXACT [UniProtKB:P02538] synonym: "K6a keratin" EXACT [UniProtKB:P02538] xref: EMBL:AAB60696.1 xref: EMBL:AAC41767.1 xref: EMBL:AAH08807.1 xref: EMBL:AAH14152.1 xref: EMBL:AAH69269.1 xref: EMBL:AAI25059.1 xref: EMBL:AAP35545.1 xref: EMBL:CAA24760.1 xref: UniProtKB:P02538 xref: UniProtKB:P48667 xref: UniProtKB:Q08AR4 xref: UniProtKB:Q6NT67 xref: UniProtKB:Q96CL4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004927 ! KRT6A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0012480 ! K2C6A_HUMAN-Phosphoserine60 relationship: transforms_into CCO:B0041308 ! K2C6A_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005822 name: HSP71_HUMAN def: "Heat shock 70 kDa protein 1" [UniProtKB:P08107] synonym: "HSP70-1/HSP70-2" EXACT [UniProtKB:P08107] synonym: "HSP70.1" EXACT [UniProtKB:P08107] xref: EMBL:AAA52697.1 xref: EMBL:AAA59844.1 xref: EMBL:AAA59845.1 xref: EMBL:AAA63226.1 xref: EMBL:AAA63227.1 xref: EMBL:AAD21815.1 xref: EMBL:AAD21816.1 xref: EMBL:AAH02453.1 xref: EMBL:AAH09322.1 xref: EMBL:AAH18740.1 xref: EMBL:AAH57397.1 xref: EMBL:AAH63507.1 xref: EMBL:ABD48956.1 xref: EMBL:ABD96830.1 xref: EMBL:BAB63299.1 xref: EMBL:BAB63300.1 xref: EMBL:CAA28381.1 xref: EMBL:CAA28382.1 xref: EMBL:CAI17737.1 xref: EMBL:CAI17738.1 xref: EMBL:CAI18216.1 xref: EMBL:CAI18217.1 xref: EMBL:CAI18464.1 xref: EMBL:CAI18466.1 xref: UniProtKB:P08107 xref: UniProtKB:P19790 xref: UniProtKB:Q5JQI4 xref: UniProtKB:Q5SP17 xref: UniProtKB:Q9UQL9 xref: UniProtKB:Q9UQM0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004834 ! HSPA1A_human relationship: encoded_by CCO:G0004835 ! HSPA1B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0012274 ! HSP71_HUMAN-Phosphotyrosine611 relationship: transforms_into CCO:B0012275 ! HSP71_HUMAN-Phosphoserine631 [Term] id: CCO:B0005823 name: K2C1_HUMAN def: "Keratin, type II cytoskeletal 1" [UniProtKB:P04264] synonym: "67 kDa cytokeratin" EXACT [UniProtKB:P04264] synonym: "CK-1" EXACT [UniProtKB:P04264] synonym: "Cytokeratin-1" EXACT [UniProtKB:P04264] synonym: "Hair alpha protein" EXACT [UniProtKB:P04264] synonym: "K1" EXACT [UniProtKB:P04264] synonym: "Keratin-1" EXACT [UniProtKB:P04264] xref: EMBL:AAA36153.1 xref: EMBL:AAB47721.1 xref: EMBL:AAF60327.1 xref: EMBL:AAG41947.1 xref: EMBL:AAH63697.1 xref: UniProtKB:P04264 xref: UniProtKB:Q14720 xref: UniProtKB:Q6GSJ0 xref: UniProtKB:Q9H298 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004925 ! KRT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007447 ! apc-ctbb1 physical interaction relationship: transforms_into CCO:B0012475 ! K2C1_HUMAN-Phosphoserine21 relationship: transforms_into CCO:B0012476 ! K2C1_HUMAN-Phosphoserine66 relationship: transforms_into CCO:B0012477 ! K2C1_HUMAN-Phosphotyrosine295 relationship: transforms_into CCO:B0012478 ! K2C1_HUMAN-Phosphothreonine297 [Term] id: CCO:B0005824 name: CTNA1_HUMAN def: "Catenin alpha-1" [UniProtKB:P35221] synonym: "Alpha E-catenin" EXACT [UniProtKB:P35221] synonym: "Cadherin-associated protein" EXACT [UniProtKB:P35221] synonym: "NY-REN-13 antigen" EXACT [UniProtKB:P35221] xref: EMBL:AAA18949.1 xref: EMBL:AAA35502.1 xref: EMBL:AAA86430.1 xref: EMBL:AAC99459.1 xref: EMBL:AAH00385.1 xref: EMBL:AAW56940.1 xref: EMBL:BAA02979.1 xref: EMBL:BAA03530.1 xref: UniProtKB:P35221 xref: UniProtKB:Q12795 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004416 ! CTNNA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0011367 ! CTNA1_HUMAN-Phosphoserine641 relationship: transforms_into CCO:B0011368 ! CTNA1_HUMAN-Phosphoserine652 relationship: transforms_into CCO:B0011369 ! CTNA1_HUMAN-Phosphothreonine654 relationship: transforms_into CCO:B0011370 ! CTNA1_HUMAN-Phosphoserine655 relationship: transforms_into CCO:B0011371 ! CTNA1_HUMAN-Phosphothreonine658 [Term] id: CCO:B0005825 name: S10AB_HUMAN def: "Protein S100-A11" [UniProtKB:P31949] synonym: "Calgizzarin" EXACT [UniProtKB:P31949] synonym: "MLN 70" EXACT [UniProtKB:P31949] synonym: "Protein S100C" EXACT [UniProtKB:P31949] synonym: "S100 calcium-binding protein A11" EXACT [UniProtKB:P31949] xref: EMBL:AAH01410.1 xref: EMBL:AAH14354.1 xref: EMBL:AAP88914.1 xref: EMBL:BAA07597.1 xref: EMBL:BAA08354.1 xref: EMBL:BAA23325.1 xref: EMBL:CAA56492.1 xref: EMBL:CAH72895.1 xref: UniProtKB:P31949 xref: UniProtKB:Q5VTK0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005555 ! S100A11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007148 ! s100b-s100a11-s100a6 colocalization relationship: transforms_into CCO:B0013950 ! S10AB_HUMAN-Phosphoserine6 [Term] id: CCO:B0005826 name: PKP2_HUMAN def: "Plakophilin-2" [UniProtKB:Q99959] xref: EMBL:CAA66264.1 xref: EMBL:CAA66265.1 xref: UniProtKB:Q99959 xref: UniProtKB:Q99960 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005330 ! PKP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0013551 ! PKP2_HUMAN-Phosphoserine132 relationship: transforms_into CCO:B0013552 ! PKP2_HUMAN-Phosphoserine169 [Term] id: CCO:B0005827 name: ATPB_HUMAN def: "ATP synthase subunit beta, mitochondrial precursor" [UniProtKB:P06576] synonym: "EC 3.6.3.14" EXACT [UniProtKB:P06576] xref: EMBL:AAA51808.1 xref: EMBL:AAA51809.1 xref: EMBL:AAH16512.1 xref: EMBL:BAA00016.1 xref: EMBL:CAA27246.1 xref: EMBL:CAA29095.1 xref: UniProtKB:P06576 xref: UniProtKB:Q14283 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004120 ! ATP5B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0008808 ! psme3-atp5b physical interaction relationship: transforms_into CCO:B0010687 ! ATPB_HUMAN-N6-acetyllysine133 relationship: transforms_into CCO:B0010688 ! ATPB_HUMAN-N6-acetyllysine259 relationship: transforms_into CCO:B0010689 ! ATPB_HUMAN-N6-acetyllysine522 relationship: transforms_into CCO:B0010690 ! ATPB_HUMAN-Phosphoserine529 [Term] id: CCO:B0005828 name: GRP75_HUMAN def: "Stress-70 protein, mitochondrial precursor" [UniProtKB:P38646] synonym: "75 kDa glucose-regulated protein" EXACT [UniProtKB:P38646] synonym: "GRP 75" EXACT [UniProtKB:P38646] synonym: "Heat shock 70 kDa protein 9" EXACT [UniProtKB:P38646] synonym: "Mortalin" EXACT [UniProtKB:P38646] synonym: "MOT" EXACT [UniProtKB:P38646] synonym: "PBP74" EXACT [UniProtKB:P38646] synonym: "Peptide-binding protein 74" EXACT [UniProtKB:P38646] xref: EMBL:AAA67526.1 xref: EMBL:AAH00478.1 xref: EMBL:AAH24034.1 xref: UniProtKB:P30036 xref: UniProtKB:P31932 xref: UniProtKB:P38646 xref: UniProtKB:Q6GU03 xref: UniProtKB:Q9BWB7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004731 ! HSPA9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0011982 ! GRP75_HUMAN-Phosphoserine200 relationship: transforms_into CCO:B0011983 ! GRP75_HUMAN-N6-acetyllysine288 relationship: transforms_into CCO:B0011984 ! GRP75_HUMAN-N6-acetyllysine300 [Term] id: CCO:B0005829 name: CKAP4_HUMAN def: "Cytoskeleton-associated protein 4" [UniProtKB:Q07065] synonym: "63 kDa membrane protein" EXACT [UniProtKB:Q07065] synonym: "p63" EXACT [UniProtKB:Q07065] xref: EMBL:AAH82972.1 xref: EMBL:AAH94824.1 xref: EMBL:BAD97283.1 xref: EMBL:CAA49535.2 xref: UniProtKB:Q07065 xref: UniProtKB:Q504S5 xref: UniProtKB:Q53ES6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004362 ! CKAP4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0011242 ! CKAP4_HUMAN-Phosphoserine17 [Term] id: CCO:B0005830 name: FHL2_HUMAN def: "Four and a half LIM domains protein 2" [UniProtKB:Q14192] synonym: "FHL-2" EXACT [UniProtKB:Q14192] synonym: "LIM domain protein DRAL" EXACT [UniProtKB:Q14192] synonym: "Skeletal muscle LIM-protein 3" EXACT [UniProtKB:Q14192] synonym: "SLIM 3" EXACT [UniProtKB:Q14192] xref: EMBL:AAA85333.1 xref: EMBL:AAC50794.1 xref: EMBL:AAC52073.1 xref: EMBL:AAH14397.1 xref: EMBL:BAA92253.1 xref: UniProtKB:Q13229 xref: UniProtKB:Q13644 xref: UniProtKB:Q14192 xref: UniProtKB:Q9P294 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004646 ! FHL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction [Term] id: CCO:B0005831 name: EF1A1_HUMAN def: "Elongation factor 1-alpha 1" [UniProtKB:P68104] synonym: "eEF1A-1" EXACT [UniProtKB:P68104] synonym: "EF-1-alpha-1" EXACT [UniProtKB:P68104] synonym: "EF-Tu" EXACT [UniProtKB:P68104] synonym: "Elongation factor 1 A-1" EXACT [UniProtKB:P68104] synonym: "Elongation factor Tu" EXACT [UniProtKB:P68104] synonym: "Leukocyte receptor cluster member 7" EXACT [UniProtKB:P68104] xref: EMBL:AAA52343.1 xref: EMBL:AAA52367.1 xref: EMBL:AAH08587.1 xref: EMBL:AAH09733.1 xref: EMBL:AAH09875.1 xref: EMBL:AAH10735.1 xref: EMBL:AAH12891.1 xref: EMBL:AAH14224.1 xref: EMBL:AAH18150.1 xref: EMBL:AAH18641.1 xref: EMBL:AAH19669.1 xref: EMBL:AAH21686.1 xref: EMBL:AAH28674.1 xref: EMBL:AAH38339.1 xref: EMBL:AAH57391.1 xref: EMBL:AAH66893.1 xref: EMBL:AAH72385.1 xref: EMBL:AAH82268.1 xref: EMBL:AAK95378.1 xref: EMBL:CAA27245.1 xref: EMBL:CAA27325.1 xref: EMBL:CAA34756.1 xref: UniProtKB:P04719 xref: UniProtKB:P04720 xref: UniProtKB:P68104 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004545 ! EEF1A1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: participates_in CCO:I0007985 ! dleu1-eef1a1 physical interaction relationship: participates_in CCO:I0007998 ! axin1-eef1a1 physical interaction relationship: participates_in CCO:I0008006 ! cks2-eef1a1 physical interaction relationship: participates_in CCO:I0008130 ! mad2l1bp-eef1a1 physical interaction relationship: participates_in CCO:I0008178 ! tp53bp2-eef1a1 physical interaction relationship: participates_in CCO:I0008202 ! brms1-eef1a1 physical interaction relationship: participates_in CCO:I0008270 ! mnat1-eef1a1 physical interaction relationship: transforms_into CCO:B0011634 ! EF1A1_HUMAN-Phosphotyrosine29 relationship: transforms_into CCO:B0011635 ! EF1A1_HUMAN-N6,N6,N6-trimethyllysine36 relationship: transforms_into CCO:B0011636 ! EF1A1_HUMAN-N6,N6-dimethyllysine55 relationship: transforms_into CCO:B0011637 ! EF1A1_HUMAN-N6,N6,N6-trimethyllysine79 relationship: transforms_into CCO:B0011638 ! EF1A1_HUMAN-Phosphotyrosine162 relationship: transforms_into CCO:B0011639 ! EF1A1_HUMAN-N6,N6-dimethyllysine165 relationship: transforms_into CCO:B0011640 ! EF1A1_HUMAN-N6,N6,N6-trimethyllysine318 relationship: transforms_into CCO:B0011641 ! EF1A1_HUMAN-N6-acetyllysine318 [Term] id: CCO:B0005832 name: EPHA2_HUMAN def: "Ephrin type-A receptor 2 precursor" [UniProtKB:P29317] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P29317] synonym: "Epithelial cell kinase" EXACT [UniProtKB:P29317] synonym: "Tyrosine-protein kinase receptor ECK" EXACT [UniProtKB:P29317] xref: EMBL:AAA53375.1 xref: UniProtKB:P29317 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004573 ! EPHA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0011720 ! EPHA2_HUMAN-Phosphoserine570 relationship: transforms_into CCO:B0011721 ! EPHA2_HUMAN-Phosphotyrosine588 relationship: transforms_into CCO:B0011722 ! EPHA2_HUMAN-Phosphotyrosine594 relationship: transforms_into CCO:B0011723 ! EPHA2_HUMAN-Phosphotyrosine772 relationship: transforms_into CCO:B0011724 ! EPHA2_HUMAN-Phosphoserine897 relationship: transforms_into CCO:B0011725 ! EPHA2_HUMAN-Phosphothreonine898 relationship: transforms_into CCO:B0011726 ! EPHA2_HUMAN-Phosphoserine901 relationship: transforms_into CCO:B0011727 ! EPHA2_HUMAN-Phosphotyrosine921 relationship: transforms_into CCO:B0011728 ! EPHA2_HUMAN-Phosphotyrosine930 [Term] id: CCO:B0005833 name: EPHB4_HUMAN def: "Ephrin type-B receptor 4 precursor" [UniProtKB:P54760] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P54760] synonym: "Tyrosine-protein kinase receptor HTK" EXACT [UniProtKB:P54760] synonym: "Tyrosine-protein kinase TYRO11" EXACT [UniProtKB:P54760] xref: EMBL:AAA20598.1 xref: EMBL:AAH04264.1 xref: EMBL:AAK21010.1 xref: UniProtKB:P54760 xref: UniProtKB:Q9BTA5 xref: UniProtKB:Q9BXP0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004575 ! EPHB4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0011734 ! EPHB4_HUMAN-Phosphotyrosine590 relationship: transforms_into CCO:B0011735 ! EPHB4_HUMAN-Phosphotyrosine596 relationship: transforms_into CCO:B0011736 ! EPHB4_HUMAN-Phosphotyrosine774 relationship: transforms_into CCO:B0011737 ! EPHB4_HUMAN-Phosphotyrosine924 [Term] id: CCO:B0005834 name: EI2BG_HUMAN def: "Translation initiation factor eIF-2B subunit gamma" [UniProtKB:Q9NR50] synonym: "eIF-2B GDP-GTP exchange factor subunit gamma" EXACT [UniProtKB:Q9NR50] xref: EMBL:AAF91351.1 xref: EMBL:AAH18728.1 xref: EMBL:BAB14770.1 xref: EMBL:CAD38962.1 xref: EMBL:CAI23131.1 xref: EMBL:CAI23132.1 xref: UniProtKB:Q5QP89 xref: UniProtKB:Q5QP90 xref: UniProtKB:Q8NDB5 xref: UniProtKB:Q8WV57 xref: UniProtKB:Q9H850 xref: UniProtKB:Q9NR50 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004556 ! EIF2B3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0041299 ! EI2BG_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0005835 name: DNJA1_HUMAN def: "DnaJ homolog subfamily A member 1" [UniProtKB:P31689] synonym: "DnaJ protein homolog 2" EXACT [UniProtKB:P31689] synonym: "HDJ-2" EXACT [UniProtKB:P31689] synonym: "Heat shock 40 kDa protein 4" EXACT [UniProtKB:P31689] synonym: "HSDJ" EXACT [UniProtKB:P31689] synonym: "HSJ-2" EXACT [UniProtKB:P31689] xref: EMBL:AAC37517.1 xref: EMBL:AAH08182.1 xref: EMBL:AAP35956.1 xref: EMBL:BAA02656.1 xref: UniProtKB:P31689 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004487 ! DNAJA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0008477 ! fzr1-dnaja1 physical interaction relationship: transforms_into CCO:B0011547 ! DNJA1_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0011548 ! DNJA1_HUMAN-Phosphoserine335 relationship: transforms_into CCO:B0011549 ! DNJA1_HUMAN-Phosphotyrosine381 [Term] id: CCO:B0005836 name: ACK1_HUMAN def: "Activated CDC42 kinase 1" [UniProtKB:Q07912] synonym: "ACK-1" EXACT [UniProtKB:Q07912] synonym: "EC 2.7.10.2" EXACT [UniProtKB:Q07912] synonym: "Tyrosine kinase non-receptor protein 2" EXACT [UniProtKB:Q07912] xref: EMBL:AAA53570.2 xref: EMBL:AAH08884.1 xref: EMBL:AAH28164.1 xref: EMBL:BAD18675.1 xref: UniProtKB:Q07912 xref: UniProtKB:Q6ZMQ0 xref: UniProtKB:Q8N6U7 xref: UniProtKB:Q96H59 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004016 ! TNK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0010427 ! ACK1_HUMAN-Phosphoserine149 relationship: transforms_into CCO:B0010428 ! ACK1_HUMAN-Phosphotyrosine284 relationship: transforms_into CCO:B0010429 ! ACK1_HUMAN-Phosphotyrosine518 relationship: transforms_into CCO:B0010430 ! ACK1_HUMAN-Phosphotyrosine826 relationship: transforms_into CCO:B0010431 ! ACK1_HUMAN-Phosphotyrosine857 relationship: transforms_into CCO:B0010432 ! ACK1_HUMAN-Phosphotyrosine858 [Term] id: CCO:B0005837 name: PAXI_HUMAN def: "Paxillin" [UniProtKB:P49023] xref: EMBL:AAC05175.1 xref: EMBL:AAC50104.1 xref: EMBL:AAD00648.1 xref: EMBL:BAA18997.1 xref: EMBL:BAA18998.1 xref: UniProtKB:O14970 xref: UniProtKB:O14971 xref: UniProtKB:O60360 xref: UniProtKB:P49023 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005271 ! PXN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0013418 ! PAXI_HUMAN-Phosphotyrosine31 relationship: transforms_into CCO:B0013419 ! PAXI_HUMAN-Phosphotyrosine88 relationship: transforms_into CCO:B0013420 ! PAXI_HUMAN-Phosphoserine106 relationship: transforms_into CCO:B0013421 ! PAXI_HUMAN-Phosphoserine109 relationship: transforms_into CCO:B0013422 ! PAXI_HUMAN-Phosphotyrosine118 relationship: transforms_into CCO:B0013423 ! PAXI_HUMAN-Phosphotyrosine181 relationship: transforms_into CCO:B0013424 ! PAXI_HUMAN-Phosphoserine303 [Term] id: CCO:B0005838 name: H14_HUMAN def: "Histone H1.4" [UniProtKB:P10412] synonym: "Histone H1b" EXACT [UniProtKB:P10412] xref: EMBL:AAA63187.1 xref: EMBL:AAH96168.1 xref: EMBL:AAH96169.1 xref: EMBL:AAH99632.1 xref: EMBL:AAN06702.1 xref: EMBL:CAC04132.1 xref: UniProtKB:P10412 xref: UniProtKB:Q4VB25 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004742 ! HIST1H1E_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0012001 ! H14_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0012002 ! H14_HUMAN-Phosphothreonine4 relationship: transforms_into CCO:B0012003 ! H14_HUMAN-Phosphothreonine18 relationship: transforms_into CCO:B0012004 ! H14_HUMAN-N6-methyllysine26 relationship: transforms_into CCO:B0012005 ! H14_HUMAN-Phosphoserine27 relationship: transforms_into CCO:B0012006 ! H14_HUMAN-Phosphoserine36 relationship: transforms_into CCO:B0012007 ! H14_HUMAN-Phosphoserine187 [Term] id: CCO:B0005839 name: CTND1_HUMAN def: "Catenin delta-1" [UniProtKB:O60716] synonym: "Cadherin-associated Src substrate" EXACT [UniProtKB:O60716] synonym: "CAS" EXACT [UniProtKB:O60716] synonym: "p120 catenin" EXACT [UniProtKB:O60716] synonym: "p120(cas)" EXACT [UniProtKB:O60716] synonym: "p120(ctn)" EXACT [UniProtKB:O60716] xref: EMBL:AAC39802.1 xref: EMBL:AAC39803.1 xref: EMBL:AAC39804.1 xref: EMBL:AAC39805.1 xref: EMBL:AAC39806.1 xref: EMBL:AAC39807.1 xref: EMBL:AAC39808.1 xref: EMBL:AAC39809.1 xref: EMBL:AAC39810.1 xref: EMBL:AAC39811.1 xref: EMBL:AAC39812.1 xref: EMBL:AAC39813.1 xref: EMBL:AAC39814.1 xref: EMBL:AAC39815.1 xref: EMBL:AAC39816.1 xref: EMBL:AAC39817.1 xref: EMBL:AAC39818.1 xref: EMBL:AAC39819.1 xref: EMBL:AAC39820.1 xref: EMBL:AAC39821.1 xref: EMBL:AAC39822.1 xref: EMBL:AAC39823.1 xref: EMBL:AAC39824.1 xref: EMBL:AAC39825.1 xref: EMBL:AAC39826.1 xref: EMBL:AAC39827.1 xref: EMBL:AAC39828.1 xref: EMBL:AAC39829.1 xref: EMBL:AAH75795.1 xref: EMBL:AAR84236.1 xref: EMBL:BAA20838.2 xref: EMBL:BAF85243.1 xref: UniProtKB:A8K939 xref: UniProtKB:O15088 xref: UniProtKB:O60713 xref: UniProtKB:O60714 xref: UniProtKB:O60715 xref: UniProtKB:O60716 xref: UniProtKB:O60935 xref: UniProtKB:Q6DHZ7 xref: UniProtKB:Q6RBX8 xref: UniProtKB:Q9UP71 xref: UniProtKB:Q9UP72 xref: UniProtKB:Q9UP73 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004418 ! CTNND1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0011385 ! CTND1_HUMAN-Phosphoserine47 relationship: transforms_into CCO:B0011386 ! CTND1_HUMAN-Phosphotyrosine96 relationship: transforms_into CCO:B0011387 ! CTND1_HUMAN-Phosphotyrosine174 relationship: transforms_into CCO:B0011388 ! CTND1_HUMAN-Phosphotyrosine217 relationship: transforms_into CCO:B0011389 ! CTND1_HUMAN-Phosphotyrosine228 relationship: transforms_into CCO:B0011390 ! CTND1_HUMAN-Phosphotyrosine257 relationship: transforms_into CCO:B0011391 ! CTND1_HUMAN-Phosphoserine268 relationship: transforms_into CCO:B0011392 ! CTND1_HUMAN-Phosphoserine269 relationship: transforms_into CCO:B0011393 ! CTND1_HUMAN-Phosphotyrosine280 relationship: transforms_into CCO:B0011394 ! CTND1_HUMAN-Phosphoserine288 relationship: transforms_into CCO:B0011395 ! CTND1_HUMAN-Phosphotyrosine291 relationship: transforms_into CCO:B0011396 ! CTND1_HUMAN-Phosphotyrosine302 relationship: transforms_into CCO:B0011397 ! CTND1_HUMAN-Phosphothreonine310 relationship: transforms_into CCO:B0011398 ! CTND1_HUMAN-Phosphoserine320 relationship: transforms_into CCO:B0011399 ! CTND1_HUMAN-Phosphotyrosine321 relationship: transforms_into CCO:B0011400 ! CTND1_HUMAN-Phosphotyrosine334 relationship: transforms_into CCO:B0011401 ! CTND1_HUMAN-Phosphoserine349 relationship: transforms_into CCO:B0011402 ! CTND1_HUMAN-Phosphoserine352 relationship: transforms_into CCO:B0011403 ! CTND1_HUMAN-Phosphoserine859 relationship: transforms_into CCO:B0011404 ! CTND1_HUMAN-Phosphotyrosine865 relationship: transforms_into CCO:B0011405 ! CTND1_HUMAN-Phosphothreonine916 relationship: transforms_into CCO:B0031307 ! CTND1_HUMAN-Phosphotyrosine904 [Term] id: CCO:B0005840 name: AT2A2_HUMAN def: "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2" [UniProtKB:P16615] synonym: "Calcium pump 2" EXACT [UniProtKB:P16615] synonym: "Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform" EXACT [UniProtKB:P16615] synonym: "EC 3.6.3.8" EXACT [UniProtKB:P16615] synonym: "Endoplasmic reticulum class 1/2 Ca(2+) ATPase" EXACT [UniProtKB:P16615] synonym: "SERCA2" EXACT [UniProtKB:P16615] synonym: "SR Ca(2+)-ATPase 2" EXACT [UniProtKB:P16615] xref: EMBL:AAA52757.1 xref: EMBL:AAA52758.1 xref: EMBL:AAA53193.1 xref: EMBL:AAA53194.1 xref: EMBL:AAH35588.1 xref: UniProtKB:P16614 xref: UniProtKB:P16615 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004113 ! ATP2A2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0010641 ! AT2A2_HUMAN-Phosphothreonine537 relationship: transforms_into CCO:B0010642 ! AT2A2_HUMAN-Phosphoserine663 [Term] id: CCO:B0005841 name: BCAR1_HUMAN def: "Breast cancer anti-estrogen resistance protein 1" [UniProtKB:P56945] synonym: "CRK-associated substrate" EXACT [UniProtKB:P56945] synonym: "p130cas" EXACT [UniProtKB:P56945] xref: EMBL:AAF27527.1 xref: EMBL:BAA92711.1 xref: EMBL:BAB55230.1 xref: EMBL:CAB75875.2 xref: UniProtKB:P56945 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004146 ! BCAR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: participates_in CCO:I0008200 ! bcar1-ppp1r15a physical interaction relationship: participates_in CCO:I0008361 ! bcar1-e2f2 physical interaction relationship: transforms_into CCO:B0010753 ! BCAR1_HUMAN-Phosphotyrosine128 relationship: transforms_into CCO:B0010754 ! BCAR1_HUMAN-Phosphoserine139 relationship: transforms_into CCO:B0010755 ! BCAR1_HUMAN-Phosphotyrosine222 relationship: transforms_into CCO:B0010756 ! BCAR1_HUMAN-Phosphotyrosine224 relationship: transforms_into CCO:B0010757 ! BCAR1_HUMAN-Phosphotyrosine234 relationship: transforms_into CCO:B0010758 ! BCAR1_HUMAN-Phosphotyrosine249 relationship: transforms_into CCO:B0010759 ! BCAR1_HUMAN-Phosphotyrosine327 relationship: transforms_into CCO:B0010760 ! BCAR1_HUMAN-Phosphotyrosine362 relationship: transforms_into CCO:B0010761 ! BCAR1_HUMAN-Phosphotyrosine387 relationship: transforms_into CCO:B0010762 ! BCAR1_HUMAN-Phosphotyrosine410 relationship: transforms_into CCO:B0010763 ! BCAR1_HUMAN-Phosphoserine639 [Term] id: CCO:B0005842 name: HSPB1_HUMAN def: "Heat shock protein beta-1" [UniProtKB:P04792] synonym: "28 kDa heat shock protein" EXACT [UniProtKB:P04792] synonym: "Estrogen-regulated 24 kDa protein" EXACT [UniProtKB:P04792] synonym: "Heat shock 27 kDa protein" EXACT [UniProtKB:P04792] synonym: "HSP 27" EXACT [UniProtKB:P04792] synonym: "HspB1" EXACT [UniProtKB:P04792] synonym: "SRP27" EXACT [UniProtKB:P04792] synonym: "Stress-responsive protein 27" EXACT [UniProtKB:P04792] xref: EMBL:AAA62175.1 xref: EMBL:AAB20722.1 xref: EMBL:AAB51056.1 xref: EMBL:AAH00510.1 xref: EMBL:AAH12768.1 xref: EMBL:AAH73768.1 xref: EMBL:AAV38691.1 xref: EMBL:ABC88475.1 xref: EMBL:BAB17232.1 xref: EMBL:CAA34498.1 xref: EMBL:CAA38016.1 xref: EMBL:CAA80636.1 xref: EMBL:CAG28542.1 xref: EMBL:CAG38728.1 xref: UniProtKB:P04792 xref: UniProtKB:Q6FI47 xref: UniProtKB:Q9UC31 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004839 ! HSPB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0008123 ! hspb1-rif1 physical interaction relationship: participates_in CCO:I0008124 ! hspb1-tp53 physical interaction relationship: transforms_into CCO:B0012279 ! HSPB1_HUMAN-Phosphoserine15 relationship: transforms_into CCO:B0012280 ! HSPB1_HUMAN-Phosphoserine26 relationship: transforms_into CCO:B0012281 ! HSPB1_HUMAN-Phosphoserine65 relationship: transforms_into CCO:B0012282 ! HSPB1_HUMAN-Phosphoserine78 relationship: transforms_into CCO:B0012283 ! HSPB1_HUMAN-Phosphoserine82 relationship: transforms_into CCO:B0012284 ! HSPB1_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0012285 ! HSPB1_HUMAN-N6-acetyllysine123 [Term] id: CCO:B0005843 name: GRP78_HUMAN def: "78 kDa glucose-regulated protein precursor" [UniProtKB:P11021] synonym: "BiP" EXACT [UniProtKB:P11021] synonym: "Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78" EXACT [UniProtKB:P11021] synonym: "GRP 78" EXACT [UniProtKB:P11021] synonym: "Heat shock 70 kDa protein 5" EXACT [UniProtKB:P11021] synonym: "Immunoglobulin heavy chain-binding protein" EXACT [UniProtKB:P11021] xref: EMBL:AAA52614.1 xref: EMBL:AAF13605.1 xref: EMBL:AAF42836.1 xref: EMBL:AAH20235.1 xref: EMBL:ABD04090.1 xref: EMBL:CAA42595.1 xref: EMBL:CAA61201.1 xref: EMBL:CAB71335.1 xref: UniProtKB:P11021 xref: UniProtKB:Q2EF78 xref: UniProtKB:Q9NPF1 xref: UniProtKB:Q9UK02 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004732 ! HSPA5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0008801 ! psme3-hspa5 physical interaction relationship: transforms_into CCO:B0011985 ! GRP78_HUMAN-Phosphothreonine166 relationship: transforms_into CCO:B0011986 ! GRP78_HUMAN-Phosphotyrosine466 relationship: transforms_into CCO:B0011987 ! GRP78_HUMAN-Phosphoserine571 [Term] id: CCO:B0005844 name: K1C17_HUMAN def: "Keratin, type I cytoskeletal 17" [UniProtKB:Q04695] synonym: "39.1" EXACT [UniProtKB:Q04695] synonym: "CK-17" EXACT [UniProtKB:Q04695] synonym: "Cytokeratin-17" EXACT [UniProtKB:Q04695] synonym: "K17" EXACT [UniProtKB:Q04695] synonym: "Keratin-17" EXACT [UniProtKB:Q04695] xref: EMBL:AAB34565.1 xref: EMBL:AAH00159.2 xref: EMBL:AAH11901.1 xref: EMBL:AAH56421.1 xref: EMBL:AAH72018.1 xref: EMBL:AAH72019.1 xref: EMBL:ABQ96595.1 xref: EMBL:ABQ96596.1 xref: EMBL:ABQ96597.1 xref: EMBL:ABQ96598.1 xref: EMBL:BAC04534.1 xref: EMBL:CAA44451.1 xref: EMBL:CAA79626.1 xref: UniProtKB:A5Z1M9 xref: UniProtKB:A5Z1N0 xref: UniProtKB:A5Z1N1 xref: UniProtKB:A5Z1N2 xref: UniProtKB:A6NDV6 xref: UniProtKB:A6NKQ2 xref: UniProtKB:Q04695 xref: UniProtKB:Q6IP98 xref: UniProtKB:Q8N1P6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004922 ! KRT17_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0012458 ! K1C17_HUMAN-Phosphoserine32 relationship: transforms_into CCO:B0012459 ! K1C17_HUMAN-Phosphoserine319 [Term] id: CCO:B0005845 name: LRC59_HUMAN def: "Leucine-rich repeat-containing protein 59" [UniProtKB:Q96AG4] xref: EMBL:AAF69611.1 xref: EMBL:AAH17168.1 xref: EMBL:AAH52279.1 xref: UniProtKB:Q96AG4 xref: UniProtKB:Q9P189 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004988 ! LRRC59_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction [Term] id: CCO:B0005846 name: FAK2_HUMAN def: "Protein tyrosine kinase 2 beta" [UniProtKB:Q14289] synonym: "CADTK" EXACT [UniProtKB:Q14289] synonym: "CAK beta" EXACT [UniProtKB:Q14289] synonym: "Calcium-dependent tyrosine kinase" EXACT [UniProtKB:Q14289] synonym: "Cell adhesion kinase beta" EXACT [UniProtKB:Q14289] synonym: "EC 2.7.10.2" EXACT [UniProtKB:Q14289] synonym: "FADK 2" EXACT [UniProtKB:Q14289] synonym: "Focal adhesion kinase 2" EXACT [UniProtKB:Q14289] synonym: "Proline-rich tyrosine kinase 2" EXACT [UniProtKB:Q14289] synonym: "RAFTK" EXACT [UniProtKB:Q14289] synonym: "Related adhesion focal tyrosine kinase" EXACT [UniProtKB:Q14289] xref: EMBL:AAB35701.1 xref: EMBL:AAB47217.1 xref: EMBL:AAC05330.1 xref: EMBL:AAC50203.1 xref: EMBL:AAH42599.1 xref: EMBL:BAA08289.1 xref: UniProtKB:Q13475 xref: UniProtKB:Q14289 xref: UniProtKB:Q14290 xref: UniProtKB:Q16709 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004607 ! PTK2B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction relationship: transforms_into CCO:B0011835 ! FAK2_HUMAN-Phosphoserine375 relationship: transforms_into CCO:B0011836 ! FAK2_HUMAN-Phosphotyrosine402 relationship: transforms_into CCO:B0011837 ! FAK2_HUMAN-Phosphotyrosine579 relationship: transforms_into CCO:B0011838 ! FAK2_HUMAN-Phosphotyrosine580 relationship: transforms_into CCO:B0011839 ! FAK2_HUMAN-Phosphotyrosine881 relationship: transforms_into CCO:B0031316 ! FAK2_HUMAN-Phosphotyrosine440 [Term] id: CCO:B0005847 name: MPCP_HUMAN def: "Phosphate carrier protein, mitochondrial precursor" [UniProtKB:Q00325] synonym: "PTP" EXACT [UniProtKB:Q00325] synonym: "Solute carrier family 25 member 3" EXACT [UniProtKB:Q00325] xref: EMBL:AAH00998.1 xref: EMBL:AAH01328.1 xref: EMBL:AAH03504.1 xref: EMBL:AAH04345.1 xref: EMBL:AAH06455.1 xref: EMBL:AAH11574.1 xref: EMBL:AAH11641.1 xref: EMBL:AAH14019.1 xref: EMBL:AAH15379.2 xref: EMBL:BAB93517.1 xref: EMBL:CAA42641.1 xref: EMBL:CAB56611.1 xref: EMBL:CAB56612.1 xref: UniProtKB:Q00325 xref: UniProtKB:Q96A03 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005115 ! SLC25A3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction relationship: transforms_into CCO:B0012980 ! MPCP_HUMAN-N6-acetyllysine99 relationship: transforms_into CCO:B0012981 ! MPCP_HUMAN-N6-acetyllysine209 [Term] id: CCO:B0005849 name: KI13B_HUMAN def: "Kinesin-like protein KIF13B" [UniProtKB:Q9NQT8] synonym: "Kinesin-like protein GAKIN" EXACT [UniProtKB:Q9NQT8] xref: EMBL:AAF81263.1 xref: EMBL:BAA31614.3 xref: EMBL:CAC29496.1 xref: UniProtKB:O75134 xref: UniProtKB:Q9BYJ6 xref: UniProtKB:Q9NQT8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004939 ! KIF13B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007135 ! dlg1-kif13b-3 physical interaction relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0012529 ! KI13B_HUMAN-Phosphoserine1410 relationship: transforms_into CCO:B0041155 ! KI13B_HUMAN-Phosphoserine1644 [Term] id: CCO:B0005850 name: GLI3_HUMAN def: "Zinc finger protein GLI3" [UniProtKB:P10071] xref: EMBL:AAA52564.1 xref: EMBL:AAI13617.1 xref: EMBL:AAI17169.1 xref: EMBL:AAP21869.1 xref: EMBL:AAS01998.1 xref: EMBL:AAS02015.1 xref: EMBL:CAB59315.1 xref: EMBL:EAL24002.1 xref: UniProtKB:A4D1W1 xref: UniProtKB:O75219 xref: UniProtKB:P10071 xref: UniProtKB:Q17RW4 xref: UniProtKB:Q75MT0 xref: UniProtKB:Q75MU9 xref: UniProtKB:Q9UDT5 xref: UniProtKB:Q9UJ39 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004702 ! GLI3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007136 ! gli3-sufu-1 direct interaction relationship: transforms_into CCO:B0011941 ! GLI3_HUMAN-Phosphoserine19 [Term] id: CCO:B0005852 name: ERBB3_HUMAN def: "Receptor tyrosine-protein kinase erbB-3 precursor" [UniProtKB:P21860] synonym: "c-erbB3" EXACT [UniProtKB:P21860] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P21860] synonym: "Tyrosine kinase-type cell surface receptor HER3" EXACT [UniProtKB:P21860] xref: EMBL:AAA35790.1 xref: EMBL:AAA35979.1 xref: EMBL:AAB26935.1 xref: EMBL:AAH82992.1 xref: UniProtKB:P21860 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004578 ! ERBB3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007143 ! erbb3-pa2g4-1 physical interaction relationship: participates_in CCO:I0007365 ! erbb1-erbb3-2 physical interaction relationship: participates_in CCO:I0007592 ! erbb1-erbb3-1 physical interaction [Term] id: CCO:B0005853 name: RL28_HUMAN def: "60S ribosomal protein L28" [UniProtKB:P46779] xref: EMBL:AAA85657.1 xref: EMBL:AAH10173.1 xref: EMBL:AAH10182.1 xref: EMBL:AAH11582.1 xref: EMBL:CAG33305.1 xref: UniProtKB:P46779 xref: UniProtKB:Q6IAY0 xref: UniProtKB:Q96FX1 xref: UniProtKB:Q9BWQ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005505 ! RPL28_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0013889 ! RL28_HUMAN-N-acetylserine2 [Term] id: CCO:B0005854 name: PABP1_HUMAN def: "Polyadenylate-binding protein 1" [UniProtKB:P11940] synonym: "PABP 1" EXACT [UniProtKB:P11940] synonym: "Poly(A)-binding protein 1" EXACT [UniProtKB:P11940] xref: EMBL:AAD08718.1 xref: EMBL:AAH15958.1 xref: EMBL:AAH23520.1 xref: EMBL:AAH41863.1 xref: EMBL:CAA68428.1 xref: EMBL:CAA88401.1 xref: UniProtKB:P11940 xref: UniProtKB:Q15097 xref: UniProtKB:Q93004 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005253 ! PABPC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0013369 ! PABP1_HUMAN-Phosphotyrosine364 relationship: transforms_into CCO:B0013370 ! PABP1_HUMAN-arginine455 relationship: transforms_into CCO:B0013371 ! PABP1_HUMAN-arginine460 relationship: transforms_into CCO:B0013372 ! PABP1_HUMAN-Omega-N-methylated arginine493 relationship: transforms_into CCO:B0031362 ! PABP1_HUMAN-Phosphotyrosine116 [Term] id: CCO:B0005855 name: RL12_HUMAN def: "60S ribosomal protein L12" [UniProtKB:P30050] xref: EMBL:AAA36157.1 xref: EMBL:AAH50644.1 xref: EMBL:AAH94831.1 xref: EMBL:AAI05604.1 xref: EMBL:CAH72929.1 xref: UniProtKB:P30050 xref: UniProtKB:Q5VVV2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005497 ! RPL12_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0013881 ! RL12_HUMAN-Phosphotyrosine14 relationship: transforms_into CCO:B0013882 ! RL12_HUMAN-Phosphoserine38 relationship: transforms_into CCO:B0013883 ! RL12_HUMAN-Phosphoserine165 [Term] id: CCO:B0005856 name: RL24_HUMAN def: "60S ribosomal protein L24" [UniProtKB:P83731] synonym: "Ribosomal protein L30" EXACT [UniProtKB:P83731] xref: EMBL:AAC28251.1 xref: EMBL:AAH00690.1 xref: EMBL:AAH70193.1 xref: EMBL:BAA25836.1 xref: EMBL:BAB79466.1 xref: EMBL:CAG33010.1 xref: UniProtKB:P38663 xref: UniProtKB:P83731 xref: UniProtKB:Q6IBS3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005503 ! RPL24_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0013887 ! RL24_HUMAN-Phosphothreonine83 relationship: transforms_into CCO:B0013888 ! RL24_HUMAN-Phosphoserine86 [Term] id: CCO:B0005857 name: RL15_HUMAN def: "60S ribosomal protein L15" [UniProtKB:P61313] xref: EMBL:AAA36583.1 xref: EMBL:AAG15591.1 xref: EMBL:AAG44837.1 xref: EMBL:AAH14837.1 xref: EMBL:AAH68198.1 xref: EMBL:AAH70328.1 xref: EMBL:AAH71672.1 xref: EMBL:AAQ24859.1 xref: EMBL:BAB79461.1 xref: UniProtKB:P39030 xref: UniProtKB:P41051 xref: UniProtKB:P61313 xref: UniProtKB:Q6IPX6 xref: UniProtKB:Q8WYP2 xref: UniProtKB:Q96C44 xref: UniProtKB:Q9H2E5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005498 ! RPL15_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction [Term] id: CCO:B0005858 name: RL11_HUMAN def: "60S ribosomal protein L11" [UniProtKB:P62913] synonym: "CLL-associated antigen KW-12" EXACT [UniProtKB:P62913] xref: EMBL:AAC15856.1 xref: EMBL:AAD20460.3 xref: EMBL:AAH18970.1 xref: EMBL:AAL99919.1 xref: EMBL:BAA25831.1 xref: EMBL:CAA55816.1 xref: UniProtKB:P25121 xref: UniProtKB:P39026 xref: UniProtKB:P62913 xref: UniProtKB:Q8TDH2 xref: UniProtKB:Q9Y674 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005496 ! RPL11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0013880 ! RL11_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005859 name: RL27_HUMAN def: "60S ribosomal protein L27" [UniProtKB:P61353] xref: EMBL:AAA19815.1 xref: EMBL:AAC15857.1 xref: EMBL:AAH01700.1 xref: EMBL:AAH02588.1 xref: EMBL:AAH07273.1 xref: EMBL:AAH10026.1 xref: EMBL:AAH98560.1 xref: EMBL:BAB79492.1 xref: UniProtKB:P08526 xref: UniProtKB:P61353 xref: UniProtKB:Q4G0A9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005504 ! RPL27_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction [Term] id: CCO:B0005860 name: RL8_HUMAN def: "60S ribosomal protein L8" [UniProtKB:P62917] xref: EMBL:AAH00047.2 xref: EMBL:AAH00077.1 xref: EMBL:AAH12197.1 xref: EMBL:AAH13104.1 xref: EMBL:AAH93064.1 xref: EMBL:AAP36043.1 xref: EMBL:BAA25829.1 xref: EMBL:BAB79459.1 xref: EMBL:CAA82248.1 xref: EMBL:CAG33327.1 xref: UniProtKB:P25120 xref: UniProtKB:P62917 xref: UniProtKB:Q567Q7 xref: UniProtKB:Q969V7 xref: UniProtKB:Q9BWQ9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005510 ! RPL8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: participates_in CCO:I0008171 ! supt5h-rpl8 physical interaction relationship: transforms_into CCO:B0013895 ! RL8_HUMAN-Phosphotyrosine133 [Term] id: CCO:B0005861 name: RL4_HUMAN def: "60S ribosomal protein L4" [UniProtKB:P36578] synonym: "L1" EXACT [UniProtKB:P36578] xref: EMBL:AAA60281.2 xref: EMBL:AAH01365.1 xref: EMBL:AAH05817.1 xref: EMBL:AAH07748.1 xref: EMBL:AAH07996.1 xref: EMBL:AAH09888.1 xref: EMBL:AAH10151.1 xref: EMBL:AAH14653.1 xref: EMBL:AAH66925.1 xref: EMBL:AAH95427.1 xref: EMBL:BAA04887.1 xref: EMBL:BAB79458.1 xref: UniProtKB:P36578 xref: UniProtKB:P39029 xref: UniProtKB:Q4VBR0 xref: UniProtKB:Q969Z9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005507 ! RPL4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0013890 ! RL4_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013891 ! RL4_HUMAN-Phosphoserine295 [Term] id: CCO:B0005862 name: RL21_HUMAN def: "60S ribosomal protein L21" [UniProtKB:P46778] xref: EMBL:AAA80462.1 xref: EMBL:AAA85655.1 xref: EMBL:AAA93231.1 xref: EMBL:AAH01603.1 xref: EMBL:AAH07505.1 xref: EMBL:AAH62981.1 xref: EMBL:AAH70184.1 xref: EMBL:AAH70323.1 xref: EMBL:AAH70330.1 xref: EMBL:BAA25835.1 xref: EMBL:BAB79464.1 xref: EMBL:CAA61582.1 xref: UniProtKB:P46778 xref: UniProtKB:Q16699 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005501 ! RPL21_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: participates_in CCO:I0008501 ! rpl21-pim2 physical interaction relationship: transforms_into CCO:B0036028 ! RL21_HUMAN-Phosphothreonine47 [Term] id: CCO:B0005863 name: H11_HUMAN def: "Histone H1.1" [UniProtKB:Q02539] xref: EMBL:AAH69492.1 xref: EMBL:AAI01594.1 xref: EMBL:AAI12141.1 xref: EMBL:AAN06699.1 xref: EMBL:CAA40409.1 xref: UniProtKB:Q02539 xref: UniProtKB:Q3MJ34 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004741 ! HIST1H1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0011999 ! H11_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0012000 ! H11_HUMAN-Phosphothreonine162 [Term] id: CCO:B0005864 name: RLA2_HUMAN def: "60S acidic ribosomal protein P2" [UniProtKB:P05387] synonym: "Renal carcinoma antigen NY-REN-44" EXACT [UniProtKB:P05387] xref: EMBL:AAA36472.1 xref: EMBL:AAH05354.1 xref: EMBL:AAH05920.1 xref: EMBL:AAH07573.1 xref: EMBL:AAH62314.1 xref: EMBL:BAB79475.1 xref: UniProtKB:P05387 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005513 ! RPLP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007145 ! pa2g4-ncl-top1-1 physical interaction relationship: transforms_into CCO:B0013904 ! RLA2_HUMAN-Phosphoserine17 relationship: transforms_into CCO:B0013905 ! RLA2_HUMAN-Phosphoserine102 relationship: transforms_into CCO:B0013906 ! RLA2_HUMAN-Phosphoserine105 relationship: transforms_into CCO:B0036029 ! RLA2_HUMAN-Phosphoserine16 [Term] id: CCO:B0005865 name: TF65_HUMAN def: "Transcription factor p65" [UniProtKB:Q04206] synonym: "Nuclear factor NF-kappa-B p65 subunit" EXACT [UniProtKB:Q04206] xref: EMBL:AAA20946.1 xref: EMBL:AAA36408.1 xref: EMBL:AAH33522.1 xref: EMBL:AAR13863.1 xref: EMBL:CAA80524.2 xref: UniProtKB:Q04206 xref: UniProtKB:Q6GTV1 xref: UniProtKB:Q6SLK1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005765 ! RELA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007150 ! cbp-atf3 physical interaction relationship: transforms_into CCO:B0014345 ! TF65_HUMAN-Phosphoserine276 relationship: transforms_into CCO:B0041207 ! TF65_HUMAN-N6-acetyllysine122 relationship: transforms_into CCO:B0041208 ! TF65_HUMAN-N6-acetyllysine123 relationship: transforms_into CCO:B0041209 ! TF65_HUMAN-Phosphothreonine254 relationship: transforms_into CCO:B0041210 ! TF65_HUMAN-Phosphoserine281 relationship: transforms_into CCO:B0041211 ! TF65_HUMAN-N6-acetyllysine310 relationship: transforms_into CCO:B0041212 ! TF65_HUMAN-Phosphoserine311 relationship: transforms_into CCO:B0041213 ! TF65_HUMAN-Phosphothreonine435 relationship: transforms_into CCO:B0041214 ! TF65_HUMAN-Phosphoserine468 relationship: transforms_into CCO:B0041215 ! TF65_HUMAN-Phosphothreonine505 relationship: transforms_into CCO:B0041216 ! TF65_HUMAN-Phosphoserine529 relationship: transforms_into CCO:B0041217 ! TF65_HUMAN-Phosphoserine536 [Term] id: CCO:B0005866 name: RANB3_HUMAN def: "Ran-binding protein 3" [UniProtKB:Q9H6Z4] synonym: "RanBP3" EXACT [UniProtKB:Q9H6Z4] xref: EMBL:AAC14485.1 xref: EMBL:AAH04349.1 xref: EMBL:BAB15106.1 xref: EMBL:CAA69956.1 xref: EMBL:CAA69957.1 xref: EMBL:CAB43293.1 xref: UniProtKB:O60405 xref: UniProtKB:O75759 xref: UniProtKB:O75760 xref: UniProtKB:Q9BT47 xref: UniProtKB:Q9H6Z4 xref: UniProtKB:Q9UG74 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005423 ! RANBP3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007153 ! ranbp3-ran-1 physical interaction relationship: participates_in CCO:I0007154 ! ranbp3-rcc1-1 physical interaction relationship: participates_in CCO:I0007298 ! rcc1-ranbp3-1 physical interaction relationship: transforms_into CCO:B0013692 ! RANB3_HUMAN-Phosphoserine96 relationship: transforms_into CCO:B0013693 ! RANB3_HUMAN-Phosphoserine100 relationship: transforms_into CCO:B0013694 ! RANB3_HUMAN-Phosphoserine101 relationship: transforms_into CCO:B0013695 ! RANB3_HUMAN-Phosphoserine108 relationship: transforms_into CCO:B0013696 ! RANB3_HUMAN-Phosphotyrosine115 relationship: transforms_into CCO:B0013697 ! RANB3_HUMAN-Phosphoserine126 relationship: transforms_into CCO:B0013698 ! RANB3_HUMAN-Phosphoserine133 relationship: transforms_into CCO:B0013699 ! RANB3_HUMAN-Phosphoserine221 relationship: transforms_into CCO:B0013700 ! RANB3_HUMAN-Phosphoserine359 relationship: transforms_into CCO:B0036025 ! RANB3_HUMAN-Phosphoserine333 [Term] id: CCO:B0005867 name: XPO1_HUMAN def: "Exportin-1" [UniProtKB:O14980] synonym: "Chromosome region maintenance 1 protein homolog" EXACT [UniProtKB:O14980] synonym: "Exp1" EXACT [UniProtKB:O14980] xref: EMBL:AAH32847.1 xref: EMBL:AAY14949.1 xref: EMBL:BAA23415.1 xref: EMBL:CAA69905.2 xref: EMBL:CAH18695.1 xref: EMBL:CAH56174.1 xref: UniProtKB:O14980 xref: UniProtKB:Q63HP8 xref: UniProtKB:Q68CP3 xref: UniProtKB:Q99433 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005940 ! XPO1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007155 ! rcc1-xpo1-1 physical interaction relationship: transforms_into CCO:B0014714 ! XPO1_HUMAN-Phosphoserine397 [Term] id: CCO:B0005870 name: TGFA_HUMAN def: "Protransforming growth factor alpha precursor" [UniProtKB:P01135] xref: EMBL:AAA52530.1 xref: EMBL:AAA61157.1 xref: EMBL:AAA61159.1 xref: EMBL:AAF13491.1 xref: EMBL:CAA49806.1 xref: UniProtKB:P01135 xref: UniProtKB:Q15577 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005772 ! TGFA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007167 ! egfr-tgfa-1 direct interaction relationship: participates_in CCO:P0000251 ! positive regulation of mitosis [Term] id: CCO:B0005872 name: AAPK1_HUMAN def: "5'-AMP-activated protein kinase catalytic subunit alpha-1" [UniProtKB:Q13131] synonym: "AMPK alpha-1 chain" EXACT [UniProtKB:Q13131] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q13131] xref: EMBL:AAA64850.1 xref: EMBL:AAD43027.1 xref: EMBL:AAH37303.1 xref: EMBL:BAA36547.1 xref: EMBL:CAA73361.1 xref: UniProtKB:O00286 xref: UniProtKB:Q13131 xref: UniProtKB:Q5D0E1 xref: UniProtKB:Q9UNQ4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004008 ! PRKAA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007179 ! prkaa1-aakg1-1 physical interaction relationship: transforms_into CCO:B0010388 ! AAPK1_HUMAN-Phosphothreonine174 relationship: transforms_into CCO:B0010389 ! AAPK1_HUMAN-Phosphoserine175 relationship: transforms_into CCO:B0010390 ! AAPK1_HUMAN-Phosphoserine499 relationship: transforms_into CCO:B0026336 ! AAPK1_HUMAN-Phosphoserine487 [Term] id: CCO:B0005874 name: NUAK2_HUMAN def: "NUAK family SNF1-like kinase 2" [UniProtKB:Q9H093] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9H093] synonym: "SNARK" EXACT [UniProtKB:Q9H093] synonym: "SNF1/AMP kinase-related kinase" EXACT [UniProtKB:Q9H093] xref: EMBL:AAH17306.1 xref: EMBL:BAC11234.1 xref: EMBL:CAB66825.1 xref: UniProtKB:Q9H093 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005219 ! NUAK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007182 ! nuak2-cdc37-1 physical interaction relationship: transforms_into CCO:B0013264 ! NUAK2_HUMAN-Phosphothreonine208 relationship: transforms_into CCO:B0013265 ! NUAK2_HUMAN-Phosphoserine212 relationship: transforms_into CCO:B0013266 ! NUAK2_HUMAN-Phosphoserine377 relationship: transforms_into CCO:B0013267 ! NUAK2_HUMAN-Phosphoserine386 relationship: transforms_into CCO:B0013268 ! NUAK2_HUMAN-Phosphoserine585 [Term] id: CCO:B0005875 name: CD59_HUMAN def: "CD59 glycoprotein precursor" [UniProtKB:P13987] synonym: "1F5 antigen" EXACT [UniProtKB:P13987] synonym: "20 kDa homologous restriction factor" EXACT [UniProtKB:P13987] synonym: "HRF-20" EXACT [UniProtKB:P13987] synonym: "HRF20" EXACT [UniProtKB:P13987] synonym: "MAC-inhibitory protein" EXACT [UniProtKB:P13987] synonym: "MAC-IP" EXACT [UniProtKB:P13987] synonym: "MACIF" EXACT [UniProtKB:P13987] synonym: "MEM43 antigen" EXACT [UniProtKB:P13987] synonym: "Membrane attack complex inhibition factor" EXACT [UniProtKB:P13987] synonym: "Membrane inhibitor of reactive lysis" EXACT [UniProtKB:P13987] synonym: "MIRL" EXACT [UniProtKB:P13987] synonym: "Protectin" EXACT [UniProtKB:P13987] xref: EMBL:AAA51952.1 xref: EMBL:AAA60543.1 xref: EMBL:AAA60957.1 xref: EMBL:AAA88793.1 xref: EMBL:AAH01506.1 xref: EMBL:AAP35768.1 xref: EMBL:CAA34467.1 xref: EMBL:CAA35059.1 xref: EMBL:CAA78486.1 xref: UniProtKB:P13987 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004279 ! CD59_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007198 ! egfr-cd59-1 direct interaction [Term] id: CCO:B0005876 name: CAB39_HUMAN def: "Calcium-binding protein 39" [UniProtKB:Q9Y376] synonym: "Protein Mo25" EXACT [UniProtKB:Q9Y376] xref: EMBL:AAD34061.1 xref: EMBL:AAF14873.1 xref: EMBL:AAH20570.1 xref: UniProtKB:Q9Y376 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004202 ! CAB39_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007201 ! stk11-mo25-1 physical interaction relationship: participates_in CCO:I0007209 ! mo25-als2cr2-1 physical interaction relationship: participates_in CCO:I0007222 ! mo25-stk11-1 physical interaction [Term] id: CCO:B0005877 name: PNMA1_HUMAN def: "Paraneoplastic antigen Ma1" [UniProtKB:Q8ND90] synonym: "37 kDa neuronal protein" EXACT [UniProtKB:Q8ND90] synonym: "Neuron- and testis-specific protein 1" EXACT [UniProtKB:Q8ND90] xref: EMBL:AAD13810.3 xref: EMBL:AAH39577.1 xref: EMBL:AAN05100.1 xref: EMBL:CAD38995.1 xref: UniProtKB:O95144 xref: UniProtKB:Q8ND90 xref: UniProtKB:Q8NG07 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005348 ! PNMA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007227 ! pard6b-pnma1-1 physical interaction relationship: participates_in CCO:I0007228 ! pnma1-pard6b-1 physical interaction relationship: participates_in CCO:I0007230 ! pard6b-pard3-2 physical interaction relationship: participates_in CCO:I0007231 ! pard3-pnma1-1 physical interaction relationship: participates_in CCO:I0007232 ! pnma1-pard3-1 physical interaction [Term] id: CCO:B0005878 name: GABPA_HUMAN def: "GA-binding protein alpha chain" [UniProtKB:Q06546] synonym: "GABP subunit alpha" EXACT [UniProtKB:Q06546] synonym: "Nuclear respiratory factor 2 subunit alpha" EXACT [UniProtKB:Q06546] synonym: "Transcription factor E4TF1-60" EXACT [UniProtKB:Q06546] xref: EMBL:AAA65706.1 xref: EMBL:BAA02575.1 xref: UniProtKB:Q06546 xref: UniProtKB:Q12939 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004679 ! GABPA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007262 ! hcfc1-gabpa-1 physical interaction relationship: participates_in CCO:I0007263 ! hcfc1-gabp2-4 direct interaction [Term] id: CCO:B0005879 name: ATRX_HUMAN def: "Transcriptional regulator ATRX" [UniProtKB:P46100] synonym: "ATP-dependent helicase ATRX" EXACT [UniProtKB:P46100] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P46100] synonym: "X-linked helicase II" EXACT [UniProtKB:P46100] synonym: "X-linked nuclear protein" EXACT [UniProtKB:P46100] synonym: "XNP" EXACT [UniProtKB:P46100] synonym: "Znf-HX" EXACT [UniProtKB:P46100] xref: EMBL:AAA20872.1 xref: EMBL:AAB40698.1 xref: EMBL:AAB40699.1 xref: EMBL:AAB40700.1 xref: EMBL:AAB49969.1 xref: EMBL:AAB49970.2 xref: EMBL:AAB49971.2 xref: EMBL:AAC50069.1 xref: EMBL:AAC51655.1 xref: EMBL:AAC51657.1 xref: EMBL:BAC80270.1 xref: EMBL:BAC80271.1 xref: EMBL:BAC80272.1 xref: EMBL:BAC80273.1 xref: EMBL:BAC80274.1 xref: EMBL:BAC80275.1 xref: EMBL:BAC80276.1 xref: EMBL:BAC80277.1 xref: EMBL:BAC80278.1 xref: EMBL:BAC80279.1 xref: EMBL:BAC80280.1 xref: EMBL:BAC80281.1 xref: EMBL:BAC80282.1 xref: EMBL:BAC80283.1 xref: EMBL:BAC80284.1 xref: EMBL:BAC80285.1 xref: EMBL:BAC80286.1 xref: EMBL:BAC80287.1 xref: EMBL:BAC80288.1 xref: EMBL:BAC80289.1 xref: EMBL:BAC81110.1 xref: EMBL:BAD92165.1 xref: EMBL:BAD92782.1 xref: EMBL:CAA58711.1 xref: EMBL:CAB90351.2 xref: EMBL:CAI40710.1 xref: EMBL:CAI42674.1 xref: EMBL:CAI42675.1 xref: EMBL:CAI43115.1 xref: EMBL:CAI43116.1 xref: UniProtKB:P46100 xref: UniProtKB:P51068 xref: UniProtKB:Q15886 xref: UniProtKB:Q59FB5 xref: UniProtKB:Q59H31 xref: UniProtKB:Q5H9A2 xref: UniProtKB:Q5JWI4 xref: UniProtKB:Q7Z2J1 xref: UniProtKB:Q9H0Z1 xref: UniProtKB:Q9NTS3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004123 ! ATRX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007270 ! nek1-xh2-1 physical interaction relationship: transforms_into CCO:B0010695 ! ATRX_HUMAN-Phosphoserine34 relationship: transforms_into CCO:B0010696 ! ATRX_HUMAN-Phosphoserine71 relationship: transforms_into CCO:B0010697 ! ATRX_HUMAN-Phosphoserine74 relationship: transforms_into CCO:B0010698 ! ATRX_HUMAN-Phosphothreonine87 relationship: transforms_into CCO:B0010699 ! ATRX_HUMAN-Phosphoserine92 relationship: transforms_into CCO:B0010700 ! ATRX_HUMAN-Phosphoserine634 relationship: transforms_into CCO:B0010701 ! ATRX_HUMAN-Phosphoserine729 relationship: transforms_into CCO:B0010702 ! ATRX_HUMAN-Phosphoserine731 relationship: transforms_into CCO:B0010703 ! ATRX_HUMAN-Phosphoserine849 relationship: transforms_into CCO:B0010704 ! ATRX_HUMAN-Phosphoserine850 relationship: transforms_into CCO:B0010705 ! ATRX_HUMAN-Phosphoserine871 relationship: transforms_into CCO:B0010706 ! ATRX_HUMAN-Phosphoserine1348 relationship: transforms_into CCO:B0010707 ! ATRX_HUMAN-Phosphoserine1352 relationship: transforms_into CCO:B0010708 ! ATRX_HUMAN-Phosphoserine1527 [Term] id: CCO:B0005880 name: KIF3A_HUMAN def: "Kinesin-like protein KIF3A" [UniProtKB:Q9Y496] synonym: "Microtubule plus end-directed kinesin motor 3A" EXACT [UniProtKB:Q9Y496] xref: EMBL:AAC04475.1 xref: EMBL:AAC72294.1 xref: EMBL:AAH45542.1 xref: EMBL:BAD93017.1 xref: UniProtKB:Q59EN1 xref: UniProtKB:Q86XE9 xref: UniProtKB:Q9Y496 xref: UniProtKB:Q9Y6V4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004948 ! KIF3A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007273 ! nek1-kif3a physical interaction relationship: transforms_into CCO:B0012607 ! KIF3A_HUMAN-Phosphoserine690 [Term] id: CCO:B0005881 name: CTNL1_HUMAN def: "Alpha-catulin" [UniProtKB:Q9UBT7] synonym: "ACRP" EXACT [UniProtKB:Q9UBT7] synonym: "Alpha-catenin-related protein" EXACT [UniProtKB:Q9UBT7] synonym: "Catenin alpha-like protein 1" EXACT [UniProtKB:Q9UBT7] xref: EMBL:AAC26011.1 xref: EMBL:AAC27693.1 xref: EMBL:AAC69576.1 xref: EMBL:AAC83460.1 xref: EMBL:AAF07819.1 xref: EMBL:AAF07820.1 xref: EMBL:AAF07821.1 xref: EMBL:AAI17209.1 xref: EMBL:AAI17235.1 xref: EMBL:AAR92479.1 xref: EMBL:BAD96950.1 xref: EMBL:CAB43238.1 xref: EMBL:CAI39471.1 xref: EMBL:CAI39472.1 xref: UniProtKB:O76084 xref: UniProtKB:Q53FQ2 xref: UniProtKB:Q5JTQ7 xref: UniProtKB:Q5JTQ8 xref: UniProtKB:Q9UBT7 xref: UniProtKB:Q9Y401 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004419 ! CTNNAL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007276 ! nek1-ctnnal1-1 physical interaction [Term] id: CCO:B0005882 name: DPOD4_HUMAN def: "DNA polymerase subunit delta-4" [UniProtKB:Q9HCU8] synonym: "DNA polymerase subunit delta p12" EXACT [UniProtKB:Q9HCU8] xref: EMBL:AAG08966.1 xref: EMBL:AAX09676.1 xref: UniProtKB:Q9HCU8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004504 ! POLD4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007289 ! pold1-pold2-4 physical interaction relationship: participates_in CCO:I0007588 ! pold1-pold2-1 physical interaction relationship: participates_in CCO:I0007590 ! pold1-pold4-1 direct interaction relationship: participates_in CCO:I0007910 ! pold1-pold2-6 physical interaction relationship: participates_in CCO:I0007911 ! pold1-pold2-7 physical interaction relationship: participates_in CCO:I0007912 ! dpol-delta_human physical interaction relationship: participates_in CCO:I0007968 ! pold1pold2-8 physical interaction [Term] id: CCO:B0005883 name: DPOD2_HUMAN def: "DNA polymerase subunit delta-2" [UniProtKB:P49005] synonym: "DNA polymerase subunit delta p50" EXACT [UniProtKB:P49005] synonym: "EC 2.7.7.7" EXACT [UniProtKB:P49005] xref: EMBL:AAC50216.1 xref: EMBL:AAG09763.1 xref: EMBL:AAH00459.1 xref: EMBL:AAM51148.1 xref: UniProtKB:P49005 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004502 ! POLD2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007289 ! pold1-pold2-4 physical interaction relationship: participates_in CCO:I0007290 ! pold1-pold2-5 physical interaction relationship: participates_in CCO:I0007588 ! pold1-pold2-1 physical interaction relationship: participates_in CCO:I0007589 ! pold1-pold2-3 physical interaction relationship: participates_in CCO:I0007910 ! pold1-pold2-6 physical interaction relationship: participates_in CCO:I0007911 ! pold1-pold2-7 physical interaction relationship: participates_in CCO:I0007912 ! dpol-delta_human physical interaction [Term] id: CCO:B0005884 name: DPOD3_HUMAN def: "DNA polymerase subunit delta-3" [UniProtKB:Q15054] synonym: "DNA polymerase subunit delta p66" EXACT [UniProtKB:Q15054] xref: EMBL:BAA05039.1 xref: UniProtKB:Q15054 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004503 ! POLD3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007289 ! pold1-pold2-4 physical interaction relationship: participates_in CCO:I0007588 ! pold1-pold2-1 physical interaction relationship: participates_in CCO:I0007910 ! pold1-pold2-6 physical interaction relationship: participates_in CCO:I0007911 ! pold1-pold2-7 physical interaction relationship: participates_in CCO:I0007912 ! dpol-delta_human physical interaction relationship: transforms_into CCO:B0011572 ! DPOD3_HUMAN-Phosphoserine307 relationship: transforms_into CCO:B0011573 ! DPOD3_HUMAN-Phosphoserine407 relationship: transforms_into CCO:B0011574 ! DPOD3_HUMAN-Phosphoserine409 relationship: transforms_into CCO:B0011575 ! DPOD3_HUMAN-Phosphothreonine411 relationship: transforms_into CCO:B0011576 ! DPOD3_HUMAN-Phosphoserine413 [Term] id: CCO:B0005885 name: DPOE3_HUMAN def: "DNA polymerase epsilon subunit 3" [UniProtKB:Q9NRF9] synonym: "Arsenic-transactivated protein" EXACT [UniProtKB:Q9NRF9] synonym: "AsTP" EXACT [UniProtKB:Q9NRF9] synonym: "CHRAC-17" EXACT [UniProtKB:Q9NRF9] synonym: "Chromatin accessibility complex 17" EXACT [UniProtKB:Q9NRF9] synonym: "DNA polymerase epsilon subunit p17" EXACT [UniProtKB:Q9NRF9] synonym: "DNA polymerase II subunit 3" EXACT [UniProtKB:Q9NRF9] synonym: "EC 2.7.7.7" EXACT [UniProtKB:Q9NRF9] synonym: "HuCHRAC17" EXACT [UniProtKB:Q9NRF9] xref: EMBL:AAF72417.1 xref: EMBL:AAF90133.1 xref: EMBL:AAH03166.1 xref: EMBL:AAH04170.1 xref: EMBL:AAU15052.1 xref: EMBL:AAY57326.1 xref: EMBL:BAC11099.1 xref: EMBL:BAC11190.1 xref: EMBL:BAC11206.1 xref: EMBL:CAH70100.1 xref: UniProtKB:Q5W0U1 xref: UniProtKB:Q8N758 xref: UniProtKB:Q8NCE5 xref: UniProtKB:Q9NR32 xref: UniProtKB:Q9NRF9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004507 ! POLE3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007291 ! pole3-pole4-6 physical interaction relationship: participates_in CCO:I0007364 ! pole3-pole4-4 physical interaction relationship: participates_in CCO:I0007913 ! dpol-epsilon_human physical interaction relationship: transforms_into CCO:B0011578 ! DPOE3_HUMAN-Phosphoserine122 [Term] id: CCO:B0005886 name: DAZ1_HUMAN def: "Deleted in azoospermia protein 1" [UniProtKB:Q9NQZ3] xref: EMBL:AAF91405.1 xref: EMBL:AAF91406.1 xref: UniProtKB:Q9NQZ3 xref: UniProtKB:Q9NQZ4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004438 ! DAZ1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007300 ! daz1-boll-1 physical interaction [Term] id: CCO:B0005887 name: RFC1_HUMAN def: "Replication factor C subunit 1" [UniProtKB:P35251] synonym: "A1 140 kDa subunit" EXACT [UniProtKB:P35251] synonym: "Activator 1 140 kDa subunit" EXACT [UniProtKB:P35251] synonym: "Activator 1 large subunit" EXACT [UniProtKB:P35251] synonym: "Activator 1 subunit 1" EXACT [UniProtKB:P35251] synonym: "DNA-binding protein PO-GA" EXACT [UniProtKB:P35251] synonym: "Replication factor C large subunit" EXACT [UniProtKB:P35251] synonym: "RF-C 140 kDa subunit" EXACT [UniProtKB:P35251] xref: EMBL:AAA16121.1 xref: EMBL:AAB99788.1 xref: EMBL:AAH35297.1 xref: EMBL:AAH51751.1 xref: EMBL:AAH51786.1 xref: EMBL:AAS94325.1 xref: EMBL:CAA80355.1 xref: UniProtKB:P35251 xref: UniProtKB:Q5XKF5 xref: UniProtKB:Q6PKU0 xref: UniProtKB:Q86V41 xref: UniProtKB:Q86V46 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005472 ! RFC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007307 ! smc1-rfc1-1 physical interaction relationship: transforms_into CCO:B0013827 ! RFC1_HUMAN-Phosphoserine69 relationship: transforms_into CCO:B0013828 ! RFC1_HUMAN-Phosphoserine71 relationship: transforms_into CCO:B0013829 ! RFC1_HUMAN-Phosphoserine73 relationship: transforms_into CCO:B0013830 ! RFC1_HUMAN-Phosphoserine108 relationship: transforms_into CCO:B0013831 ! RFC1_HUMAN-Phosphothreonine110 relationship: transforms_into CCO:B0013832 ! RFC1_HUMAN-Phosphoserine156 relationship: transforms_into CCO:B0013833 ! RFC1_HUMAN-Phosphothreonine161 relationship: transforms_into CCO:B0013834 ! RFC1_HUMAN-Phosphoserine173 relationship: transforms_into CCO:B0013835 ! RFC1_HUMAN-Phosphoserine190 [Term] id: CCO:B0005888 name: BHLH2_HUMAN def: "Class B basic helix-loop-helix protein 2" [UniProtKB:O14503] synonym: "bHLHB2" EXACT [UniProtKB:O14503] synonym: "DEC1" EXACT [UniProtKB:O14503] synonym: "Differentially expressed in chondrocytes protein 1" EXACT [UniProtKB:O14503] synonym: "Enhancer-of-split and hairy-related protein 2" EXACT [UniProtKB:O14503] synonym: "SHARP-2" EXACT [UniProtKB:O14503] synonym: "Stimulated by retinoic acid gene 13 protein" EXACT [UniProtKB:O14503] xref: EMBL:AAH82238.1 xref: EMBL:AAK49525.1 xref: EMBL:BAA21720.1 xref: EMBL:BAB18565.1 xref: UniProtKB:O14503 xref: UniProtKB:Q96TD3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004159 ! BHLHB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007316 ! bhlbh2-ube2i physical interaction relationship: participates_in CCO:I0007476 ! bhlbh2-ube2i-2 physical interaction relationship: participates_in CCO:I0007511 ! bhlbh2-ube2i-1 physical interaction [Term] id: CCO:B0005891 name: MAPK5_HUMAN def: "MAP kinase-activated protein kinase 5" [UniProtKB:Q8IW41] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q8IW41] synonym: "MAPK-activated protein kinase 5" EXACT [UniProtKB:Q8IW41] synonym: "MAPKAP kinase 5" EXACT [UniProtKB:Q8IW41] synonym: "p38-regulated/activated protein kinase" EXACT [UniProtKB:Q8IW41] xref: EMBL:AAC39863.1 xref: EMBL:AAH00833.1 xref: EMBL:AAH41049.1 xref: EMBL:AAH47284.2 xref: EMBL:CAB53747.1 xref: UniProtKB:O60491 xref: UniProtKB:Q86X46 xref: UniProtKB:Q8IW41 xref: UniProtKB:Q9BVX9 xref: UniProtKB:Q9UG86 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005023 ! MAPKAPK5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007322 ! mapkapk5-tp53 phosphorylation relationship: participates_in CCO:I0007324 ! mapkapk5-tp53-1 phosphorylation relationship: transforms_into CCO:B0012762 ! MAPK5_HUMAN-Phosphothreonine182 [Term] id: CCO:B0005892 name: MK11_HUMAN def: "Mitogen-activated protein kinase 11" [UniProtKB:Q15759] synonym: "EC 2.7.11.24" EXACT [UniProtKB:Q15759] synonym: "MAP kinase p38 beta" EXACT [UniProtKB:Q15759] synonym: "Mitogen-activated protein kinase p38 beta" EXACT [UniProtKB:Q15759] synonym: "p38-2" EXACT [UniProtKB:Q15759] synonym: "p38b" EXACT [UniProtKB:Q15759] synonym: "Stress-activated protein kinase 2" EXACT [UniProtKB:Q15759] xref: EMBL:AAB05036.1 xref: EMBL:AAB66313.1 xref: EMBL:AAC12714.1 xref: EMBL:AAC51250.1 xref: EMBL:AAC51373.1 xref: EMBL:AAH27933.1 xref: EMBL:ABB72677.1 xref: EMBL:CAA74792.1 xref: EMBL:CAB51539.1 xref: EMBL:CAG30400.1 xref: UniProtKB:O00284 xref: UniProtKB:O15472 xref: UniProtKB:Q15759 xref: UniProtKB:Q2XNF2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005094 ! MAPK11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007325 ! mapk11-tp53-1 phosphorylation relationship: transforms_into CCO:B0012954 ! MK11_HUMAN-Phosphothreonine180 relationship: transforms_into CCO:B0012955 ! MK11_HUMAN-Phosphotyrosine182 [Term] id: CCO:B0005893 name: NCOA6_HUMAN def: "Nuclear receptor coactivator 6" [UniProtKB:Q14686] synonym: "Activating signal cointegrator 2" EXACT [UniProtKB:Q14686] synonym: "Amplified in breast cancer protein 3" EXACT [UniProtKB:Q14686] synonym: "ASC-2" EXACT [UniProtKB:Q14686] synonym: "Cancer-amplified transcriptional coactivator ASC-2" EXACT [UniProtKB:Q14686] synonym: "NRC RAP250" EXACT [UniProtKB:Q14686] synonym: "Nuclear receptor coactivator RAP250" EXACT [UniProtKB:Q14686] synonym: "Nuclear receptor-activating protein, 250 kDa" EXACT [UniProtKB:Q14686] synonym: "Peroxisome proliferator-activated receptor-interacting protein" EXACT [UniProtKB:Q14686] synonym: "PPAR-interacting protein" EXACT [UniProtKB:Q14686] synonym: "PRIP" EXACT [UniProtKB:Q14686] synonym: "Thyroid hormone receptor-binding protein" EXACT [UniProtKB:Q14686] xref: EMBL:AAF13595.1 xref: EMBL:AAF16403.1 xref: EMBL:AAF37003.1 xref: EMBL:AAF71829.1 xref: EMBL:AAF78480.1 xref: EMBL:BAA11498.2 xref: EMBL:CAB92721.2 xref: EMBL:EAW76254.1 xref: UniProtKB:A6NLF1 xref: UniProtKB:Q14686 xref: UniProtKB:Q9NTZ9 xref: UniProtKB:Q9UH74 xref: UniProtKB:Q9UK86 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005160 ! NCOA6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007326 ! ncoa6-rara-1 physical interaction relationship: participates_in CCO:I0007327 ! ncoa6-rara-2 physical interaction relationship: transforms_into CCO:B0013108 ! NCOA6_HUMAN-Phosphoserine884 relationship: transforms_into CCO:B0013109 ! NCOA6_HUMAN-Phosphothreonine1321 [Term] id: CCO:B0005894 name: HCK_HUMAN def: "Tyrosine-protein kinase HCK" [UniProtKB:P08631] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P08631] synonym: "Hemopoietic cell kinase" EXACT [UniProtKB:P08631] synonym: "p59-HCK/p60-HCK" EXACT [UniProtKB:P08631] xref: EMBL:AAA52643.1 xref: EMBL:AAA52644.1 xref: EMBL:AAH14435.2 xref: EMBL:AAH94847.2 xref: EMBL:AAI08931.2 xref: EMBL:AAI08932.2 xref: EMBL:AAI13855.2 xref: EMBL:AAI14464.2 xref: EMBL:BAB15482.1 xref: EMBL:CAA41565.2 xref: EMBL:CAI19694.1 xref: EMBL:CAI19695.1 xref: EMBL:CAI22966.1 xref: EMBL:CAI22967.1 xref: UniProtKB:P08631 xref: UniProtKB:Q29RX1 xref: UniProtKB:Q2VPE2 xref: UniProtKB:Q504R5 xref: UniProtKB:Q5T7K1 xref: UniProtKB:Q5T7K2 xref: UniProtKB:Q96CC0 xref: UniProtKB:Q9H5Y5 xref: UniProtKB:Q9NUA4 xref: UniProtKB:Q9UMJ5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004783 ! HCK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007329 ! hck-dnm2-1 physical interaction relationship: participates_in CCO:I0007330 ! hck-p62-1 physical interaction relationship: participates_in CCO:I0007331 ! hck-cd2ap-1 physical interaction relationship: participates_in CCO:I0007964 ! hck-sam68-1 physical interaction relationship: transforms_into CCO:B0012154 ! HCK_HUMAN-Phosphotyrosine411 [Term] id: CCO:B0005895 name: PBX2_HUMAN def: "Pre-B-cell leukemia transcription factor 2" [UniProtKB:P40425] synonym: "Homeobox protein PBX2" EXACT [UniProtKB:P40425] synonym: "Protein G17" EXACT [UniProtKB:P40425] xref: EMBL:AAB47490.1 xref: EMBL:AAH82261.1 xref: EMBL:BAA05957.1 xref: EMBL:CAA42503.1 xref: EMBL:CAA56717.1 xref: EMBL:CAI17539.1 xref: EMBL:CAI18358.1 xref: EMBL:CAI41814.1 xref: UniProtKB:P40425 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005273 ! PBX2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007333 ! pbx2-p22 physical interaction relationship: transforms_into CCO:B0013431 ! PBX2_HUMAN-Phosphoserine105 [Term] id: CCO:B0005896 name: STK19_HUMAN def: "Serine/threonine-protein kinase 19" [UniProtKB:P49842] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P49842] synonym: "Protein G11" EXACT [UniProtKB:P49842] synonym: "Protein RP1" EXACT [UniProtKB:P49842] xref: EMBL:AAA20120.1 xref: EMBL:AAA20122.1 xref: EMBL:AAA99716.1 xref: EMBL:AAB67976.1 xref: EMBL:CAA54565.1 xref: EMBL:CAA54622.1 xref: EMBL:CAA54623.1 xref: EMBL:CAB89303.1 xref: EMBL:CAB89304.1 xref: EMBL:CAI17470.2 xref: EMBL:CAI41739.1 xref: EMBL:CAM26056.1 xref: EMBL:CAM26064.1 xref: EMBL:EAX03567.1 xref: UniProtKB:A6NFW8 xref: UniProtKB:P49842 xref: UniProtKB:Q13159 xref: UniProtKB:Q31617 xref: UniProtKB:Q5ST75 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005692 ! STK19_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007334 ! stk19-pole physical interaction [Term] id: CCO:B0005898 name: BAT2_HUMAN def: "Large proline-rich protein BAT2" [UniProtKB:P48634] synonym: "HLA-B-associated transcript 2" EXACT [UniProtKB:P48634] xref: EMBL:AAA35585.1 xref: EMBL:AAA35586.1 xref: EMBL:AAD18086.1 xref: EMBL:AAH30127.1 xref: EMBL:AAH32134.1 xref: EMBL:AAH42295.1 xref: EMBL:AAH60668.1 xref: EMBL:BAB63391.1 xref: EMBL:BAE06116.1 xref: EMBL:CAA78744.1 xref: EMBL:CAH18101.1 xref: EMBL:CAI17698.2 xref: EMBL:CAI17699.1 xref: EMBL:CAI18313.1 xref: EMBL:CAI18499.1 xref: EMBL:CAI18500.1 xref: EMBL:CAI95572.1 xref: UniProtKB:O95875 xref: UniProtKB:P48634 xref: UniProtKB:Q05BK4 xref: UniProtKB:Q4LE37 xref: UniProtKB:Q5SQ29 xref: UniProtKB:Q5SQ30 xref: UniProtKB:Q5ST84 xref: UniProtKB:Q5STX6 xref: UniProtKB:Q5STX7 xref: UniProtKB:Q68DW9 xref: UniProtKB:Q6P9P7 xref: UniProtKB:Q6PIN1 xref: UniProtKB:Q8MGQ9 xref: UniProtKB:Q96QC6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004139 ! BAT2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007337 ! bat2-mad2l2 physical interaction relationship: participates_in CCO:I0008772 ! bat2-psma3 physical interaction relationship: transforms_into CCO:B0010729 ! BAT2_HUMAN-Phosphoserine114 relationship: transforms_into CCO:B0010730 ! BAT2_HUMAN-Phosphoserine204 relationship: transforms_into CCO:B0010731 ! BAT2_HUMAN-Phosphoserine342 relationship: transforms_into CCO:B0010732 ! BAT2_HUMAN-Phosphoserine350 relationship: transforms_into CCO:B0010733 ! BAT2_HUMAN-Phosphoserine380 relationship: transforms_into CCO:B0010734 ! BAT2_HUMAN-Phosphoserine456 relationship: transforms_into CCO:B0010735 ! BAT2_HUMAN-Phosphothreonine517 relationship: transforms_into CCO:B0010736 ! BAT2_HUMAN-Phosphothreonine610 relationship: transforms_into CCO:B0010737 ! BAT2_HUMAN-Phosphoserine759 relationship: transforms_into CCO:B0010738 ! BAT2_HUMAN-Phosphoserine761 relationship: transforms_into CCO:B0010739 ! BAT2_HUMAN-Phosphoserine764 relationship: transforms_into CCO:B0010740 ! BAT2_HUMAN-Phosphothreonine782 relationship: transforms_into CCO:B0010741 ! BAT2_HUMAN-Phosphoserine1004 relationship: transforms_into CCO:B0010742 ! BAT2_HUMAN-Phosphoserine1089 relationship: transforms_into CCO:B0010743 ! BAT2_HUMAN-Phosphoserine1092 relationship: transforms_into CCO:B0010744 ! BAT2_HUMAN-Phosphoserine1219 relationship: transforms_into CCO:B0010745 ! BAT2_HUMAN-Phosphothreonine1347 relationship: transforms_into CCO:B0010746 ! BAT2_HUMAN-Phosphothreonine1353 relationship: transforms_into CCO:B0026348 ! BAT2_HUMAN-Phosphoserine1014 [Term] id: CCO:B0005899 name: UAP56_HUMAN def: "Spliceosome RNA helicase BAT1" [UniProtKB:Q13838] synonym: "56 kDa U2AF65-associated protein" EXACT [UniProtKB:Q13838] synonym: "ATP-dependent RNA helicase p47" EXACT [UniProtKB:Q13838] synonym: "DEAD box protein UAP56" EXACT [UniProtKB:Q13838] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q13838] synonym: "HLA-B-associated transcript-1" EXACT [UniProtKB:Q13838] xref: EMBL:AAB94615.1 xref: EMBL:AAC63046.1 xref: EMBL:AAH00361.1 xref: EMBL:AAH13006.1 xref: EMBL:AAP88911.1 xref: EMBL:BAB63306.1 xref: EMBL:BAC54953.1 xref: EMBL:BAD96632.1 xref: EMBL:BAE78637.1 xref: EMBL:BAF31287.1 xref: EMBL:CAA85523.1 xref: EMBL:CAI17664.2 xref: EMBL:CAI17665.2 xref: EMBL:CAI18279.2 xref: EMBL:CAI18280.1 xref: EMBL:CAI18281.2 xref: EMBL:CAI18282.2 xref: EMBL:CAI18283.2 xref: EMBL:CAI18634.1 xref: EMBL:CAI18635.1 xref: EMBL:CAI18637.1 xref: EMBL:CAI41922.1 xref: UniProtKB:O43496 xref: UniProtKB:Q0EFA1 xref: UniProtKB:Q13838 xref: UniProtKB:Q2L6F9 xref: UniProtKB:Q53GL9 xref: UniProtKB:Q5RJ64 xref: UniProtKB:Q5RJ66 xref: UniProtKB:Q5ST94 xref: UniProtKB:Q5STB4 xref: UniProtKB:Q5STB5 xref: UniProtKB:Q5STB7 xref: UniProtKB:Q5STB8 xref: UniProtKB:Q5STU4 xref: UniProtKB:Q5STU5 xref: UniProtKB:Q5STU6 xref: UniProtKB:Q5STU8 xref: UniProtKB:Q71V76 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005852 ! BAT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008383 ! dnm2-bat1 physical interaction [Term] id: CCO:B0005900 name: K2C8_HUMAN def: "Keratin, type II cytoskeletal 8" [UniProtKB:P05787] synonym: "CK-8" EXACT [UniProtKB:P05787] synonym: "Cytokeratin-8" EXACT [UniProtKB:P05787] synonym: "K8" EXACT [UniProtKB:P05787] synonym: "Keratin-8" EXACT [UniProtKB:P05787] xref: EMBL:AAA35748.1 xref: EMBL:AAA35763.1 xref: EMBL:AAA51542.1 xref: EMBL:AAB18966.1 xref: EMBL:AAH00654.3 xref: EMBL:AAH63513.2 xref: EMBL:AAH73760.1 xref: EMBL:AAH75839.1 xref: EMBL:BAD96661.1 xref: EMBL:CAA31376.1 xref: EMBL:CAA52882.1 xref: EMBL:CAA52916.1 xref: EMBL:CAA67203.1 xref: UniProtKB:P05787 xref: UniProtKB:Q14099 xref: UniProtKB:Q14716 xref: UniProtKB:Q14717 xref: UniProtKB:Q53GJ0 xref: UniProtKB:Q6DHW5 xref: UniProtKB:Q6GMY0 xref: UniProtKB:Q6P4C7 xref: UniProtKB:Q96J60 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004929 ! KRT8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007341 ! krt8-krt18 physical interaction relationship: transforms_into CCO:B0012487 ! K2C8_HUMAN-Phosphoserine9 relationship: transforms_into CCO:B0012488 ! K2C8_HUMAN-Phosphoserine13 relationship: transforms_into CCO:B0012489 ! K2C8_HUMAN-Phosphoserine21 relationship: transforms_into CCO:B0012490 ! K2C8_HUMAN-Phosphoserine22 relationship: transforms_into CCO:B0012491 ! K2C8_HUMAN-Phosphoserine24 relationship: transforms_into CCO:B0012492 ! K2C8_HUMAN-Phosphothreonine26 relationship: transforms_into CCO:B0012493 ! K2C8_HUMAN-Phosphoserine27 relationship: transforms_into CCO:B0012494 ! K2C8_HUMAN-Phosphoserine34 relationship: transforms_into CCO:B0012495 ! K2C8_HUMAN-Phosphoserine37 relationship: transforms_into CCO:B0012496 ! K2C8_HUMAN-Phosphoserine43 relationship: transforms_into CCO:B0012497 ! K2C8_HUMAN-Phosphoserine44 relationship: transforms_into CCO:B0012498 ! K2C8_HUMAN-Phosphoserine74 relationship: transforms_into CCO:B0012499 ! K2C8_HUMAN-Phosphoserine253 relationship: transforms_into CCO:B0012500 ! K2C8_HUMAN-Phosphoserine330 relationship: transforms_into CCO:B0012501 ! K2C8_HUMAN-Phosphoserine417 relationship: transforms_into CCO:B0012502 ! K2C8_HUMAN-Phosphoserine424 relationship: transforms_into CCO:B0012503 ! K2C8_HUMAN-Phosphoserine432 relationship: transforms_into CCO:B0012504 ! K2C8_HUMAN-Phosphoserine451 relationship: transforms_into CCO:B0012505 ! K2C8_HUMAN-Phosphoserine475 relationship: transforms_into CCO:B0012506 ! K2C8_HUMAN-Phosphoserine478 [Term] id: CCO:B0005901 name: BCLX_HUMAN def: "Apoptosis regulator Bcl-X" [UniProtKB:Q07817] synonym: "Bcl-2-like 1 protein" EXACT [UniProtKB:Q07817] xref: EMBL:AAB17354.1 xref: EMBL:AAH19307.1 xref: EMBL:AAP35872.1 xref: EMBL:CAA80661.1 xref: EMBL:CAA80662.1 xref: EMBL:CAI12811.1 xref: EMBL:CAI23025.1 xref: UniProtKB:Q07817 xref: UniProtKB:Q5TE65 xref: UniProtKB:Q92976 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004155 ! BCL2L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007343 ! bcl_xl-bax physical interaction [Term] id: CCO:B0005902 name: LEPR_HUMAN def: "Leptin receptor precursor" [UniProtKB:P48357] synonym: "CD295 antigen" EXACT [UniProtKB:P48357] synonym: "HuB219" EXACT [UniProtKB:P48357] synonym: "LEP-R" EXACT [UniProtKB:P48357] synonym: "OB receptor" EXACT [UniProtKB:P48357] synonym: "OB-R" EXACT [UniProtKB:P48357] xref: EMBL:AAA93015.1 xref: EMBL:AAB07495.1 xref: EMBL:AAB07496.1 xref: EMBL:AAB07497.1 xref: EMBL:AAB09673.1 xref: EMBL:AAC23650.1 xref: EMBL:AAC50509.1 xref: EMBL:AAC50510.1 xref: EMBL:AAC50511.1 xref: UniProtKB:P48357 xref: UniProtKB:Q13592 xref: UniProtKB:Q13593 xref: UniProtKB:Q13594 xref: UniProtKB:Q92919 xref: UniProtKB:Q92920 xref: UniProtKB:Q92921 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004976 ! LEPR_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008259 ! lepr-pin1 physical interaction relationship: transforms_into CCO:B0012696 ! LEPR_HUMAN-Phosphotyrosine986 relationship: transforms_into CCO:B0012697 ! LEPR_HUMAN-Phosphotyrosine1141 [Term] id: CCO:B0005903 name: CASP9_HUMAN def: "Caspase-9 precursor" [UniProtKB:P55211] synonym: "APAF-3" EXACT [UniProtKB:P55211] synonym: "Apoptotic protease Mch-6" EXACT [UniProtKB:P55211] synonym: "Apoptotic protease-activating factor 3" EXACT [UniProtKB:P55211] synonym: "CASP-9" EXACT [UniProtKB:P55211] synonym: "EC 3.4.22.62" EXACT [UniProtKB:P55211] synonym: "ICE-LAP6" EXACT [UniProtKB:P55211] synonym: "ICE-like apoptotic protease 6" EXACT [UniProtKB:P55211] xref: EMBL:AAC50640.1 xref: EMBL:AAC50776.1 xref: EMBL:AAD12248.1 xref: EMBL:AAD13615.1 xref: EMBL:AAH02452.1 xref: EMBL:AAH06463.1 xref: EMBL:AAO21133.1 xref: EMBL:BAA78780.1 xref: EMBL:BAA82697.1 xref: EMBL:BAA87905.1 xref: EMBL:CAC42423.1 xref: UniProtKB:O95348 xref: UniProtKB:P55211 xref: UniProtKB:Q92852 xref: UniProtKB:Q9BQ62 xref: UniProtKB:Q9UEQ3 xref: UniProtKB:Q9UIJ8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004222 ! CASP9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007348 ! birc5-casp9 physical interaction [Term] id: CCO:B0005904 name: DPOE2_HUMAN def: "DNA polymerase epsilon subunit 2" [UniProtKB:P56282] synonym: "DNA polymerase epsilon subunit B" EXACT [UniProtKB:P56282] synonym: "DNA polymerase II subunit 2" EXACT [UniProtKB:P56282] synonym: "EC 2.7.7.7" EXACT [UniProtKB:P56282] xref: EMBL:AAC39610.1 xref: EMBL:AAC51920.1 xref: EMBL:AAI26219.1 xref: EMBL:AAI26221.1 xref: EMBL:AAK72254.1 xref: UniProtKB:A0AV55 xref: UniProtKB:O43560 xref: UniProtKB:P56282 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004506 ! POLE2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007363 ! pole3-pole4-3 physical interaction relationship: participates_in CCO:I0007913 ! dpol-epsilon_human physical interaction [Term] id: CCO:B0005905 name: DPOE4_HUMAN def: "DNA polymerase epsilon subunit 4" [UniProtKB:Q9NR33] synonym: "DNA polymerase epsilon subunit p12" EXACT [UniProtKB:Q9NR33] synonym: "DNA polymerase II subunit 4" EXACT [UniProtKB:Q9NR33] synonym: "EC 2.7.7.7" EXACT [UniProtKB:Q9NR33] xref: EMBL:AAF90132.1 xref: EMBL:AAH31331.1 xref: EMBL:AAY15030.1 xref: UniProtKB:Q53TR2 xref: UniProtKB:Q9NR33 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004508 ! POLE4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007364 ! pole3-pole4-4 physical interaction relationship: participates_in CCO:I0007913 ! dpol-epsilon_human physical interaction relationship: transforms_into CCO:B0011579 ! DPOE4_HUMAN-Phosphoserine25 [Term] id: CCO:B0005906 name: ERBB4_HUMAN def: "Receptor tyrosine-protein kinase erbB-4 precursor" [UniProtKB:Q15303] synonym: "EC 2.7.10.1" EXACT [UniProtKB:Q15303] synonym: "p180erbB4" EXACT [UniProtKB:Q15303] synonym: "Tyrosine kinase-type cell surface receptor HER4" EXACT [UniProtKB:Q15303] xref: EMBL:AAB59446.1 xref: EMBL:AAI12200.1 xref: EMBL:BAD92934.1 xref: UniProtKB:Q15303 xref: UniProtKB:Q2M1W1 xref: UniProtKB:Q59EW4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004579 ! ERBB4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007366 ! erbb1-erbb4-2 physical interaction relationship: participates_in CCO:I0007593 ! erbb1-erbb4-1 physical interaction relationship: transforms_into CCO:B0011741 ! ERBB4_HUMAN-Phosphotyrosine1162 relationship: transforms_into CCO:B0011742 ! ERBB4_HUMAN-Phosphotyrosine1188 relationship: transforms_into CCO:B0011743 ! ERBB4_HUMAN-Phosphotyrosine1258 relationship: transforms_into CCO:B0011744 ! ERBB4_HUMAN-Phosphotyrosine1284 [Term] id: CCO:B0005907 name: P66A_HUMAN def: "Transcriptional repressor p66-alpha" [UniProtKB:Q86YP4] synonym: "GATA zinc finger domain-containing protein 2A" EXACT [UniProtKB:Q86YP4] synonym: "Hp66alpha" EXACT [UniProtKB:Q86YP4] xref: EMBL:AAH11684.1 xref: EMBL:AAH12902.2 xref: EMBL:AAO31797.1 xref: EMBL:BAA90939.1 xref: EMBL:CAB99095.1 xref: UniProtKB:Q7L3J2 xref: UniProtKB:Q86YP4 xref: UniProtKB:Q96F28 xref: UniProtKB:Q9NPU2 xref: UniProtKB:Q9NXS1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005246 ! GATAD2A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007368 ! pcaf-p66a physical interaction relationship: transforms_into CCO:B0013351 ! P66A_HUMAN-Phosphoserine100 relationship: transforms_into CCO:B0013352 ! P66A_HUMAN-Phosphoserine107 relationship: transforms_into CCO:B0013353 ! P66A_HUMAN-Phosphoserine114 relationship: transforms_into CCO:B0013354 ! P66A_HUMAN-Phosphoserine546 relationship: transforms_into CCO:B0013355 ! P66A_HUMAN-Phosphoserine598 [Term] id: CCO:B0005908 name: P66B_HUMAN def: "Transcriptional repressor p66-beta" [UniProtKB:Q8WXI9] synonym: "GATA zinc finger domain-containing protein 2B" EXACT [UniProtKB:Q8WXI9] synonym: "p66/p68" EXACT [UniProtKB:Q8WXI9] xref: EMBL:AAH69419.1 xref: EMBL:AAI12053.1 xref: EMBL:AAI12081.1 xref: EMBL:AAL39080.1 xref: EMBL:BAA86464.1 xref: EMBL:CAH71425.1 xref: UniProtKB:Q5VUR2 xref: UniProtKB:Q7LG68 xref: UniProtKB:Q8WXI9 xref: UniProtKB:Q9ULS0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005247 ! GATAD2B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007369 ! pcaf-p66b-1 physical interaction relationship: transforms_into CCO:B0013356 ! P66B_HUMAN-Phosphothreonine120 relationship: transforms_into CCO:B0013357 ! P66B_HUMAN-Phosphoserine122 relationship: transforms_into CCO:B0013358 ! P66B_HUMAN-Phosphoserine129 relationship: transforms_into CCO:B0013359 ! P66B_HUMAN-Phosphoserine135 relationship: transforms_into CCO:B0013360 ! P66B_HUMAN-Phosphoserine486 [Term] id: CCO:B0005909 name: ADA15_HUMAN def: "ADAM 15 precursor" [UniProtKB:Q13444] synonym: "A disintegrin and metalloproteinase domain 15" EXACT [UniProtKB:Q13444] synonym: "EC 3.4.24.-" EXACT [UniProtKB:Q13444] synonym: "MDC-15" EXACT [UniProtKB:Q13444] synonym: "Metalloprotease RGD disintegrin protein" EXACT [UniProtKB:Q13444] synonym: "Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15" EXACT [UniProtKB:Q13444] synonym: "Metargidin" EXACT [UniProtKB:Q13444] xref: EMBL:AAC50404.1 xref: EMBL:AAC51112.1 xref: EMBL:AAH14566.1 xref: EMBL:AAM44189.1 xref: EMBL:AAP88766.1 xref: EMBL:AAS72992.1 xref: UniProtKB:Q13444 xref: UniProtKB:Q13493 xref: UniProtKB:Q53XQ0 xref: UniProtKB:Q96C78 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004026 ! ADAM15_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007391 ! adam15-mad2l2-1 physical interaction relationship: transforms_into CCO:B0010451 ! ADA15_HUMAN-Phosphotyrosine715 relationship: transforms_into CCO:B0010452 ! ADA15_HUMAN-Phosphotyrosine735 [Term] id: CCO:B0005910 name: AKT2_HUMAN def: "RAC-beta serine/threonine-protein kinase" [UniProtKB:P31751] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P31751] synonym: "PKB beta" EXACT [UniProtKB:P31751] synonym: "Protein kinase Akt-2" EXACT [UniProtKB:P31751] synonym: "Protein kinase B, beta" EXACT [UniProtKB:P31751] synonym: "RAC-PK-beta" EXACT [UniProtKB:P31751] xref: EMBL:AAA36585.1 xref: EMBL:AAA58364.1 xref: EMBL:AAI20995.1 xref: EMBL:AAT97984.1 xref: UniProtKB:P31751 xref: UniProtKB:Q0VAN1 xref: UniProtKB:Q68GC0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004046 ! AKT2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007398 ! cdc37-akt2 physical interaction relationship: transforms_into CCO:B0010493 ! AKT2_HUMAN-Phosphothreonine309 relationship: transforms_into CCO:B0010494 ! AKT2_HUMAN-Phosphoserine474 [Term] id: CCO:B0005911 name: AKT3_HUMAN def: "RAC-gamma serine/threonine-protein kinase" [UniProtKB:Q9Y243] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9Y243] synonym: "PKB gamma" EXACT [UniProtKB:Q9Y243] synonym: "Protein kinase Akt-3" EXACT [UniProtKB:Q9Y243] synonym: "Protein kinase B, gamma" EXACT [UniProtKB:Q9Y243] synonym: "RAC-PK-gamma" EXACT [UniProtKB:Q9Y243] synonym: "STK-2" EXACT [UniProtKB:Q9Y243] xref: EMBL:AAD24196.1 xref: EMBL:AAD29089.1 xref: EMBL:AAF91073.1 xref: EMBL:AAI21155.1 xref: EMBL:AAL40392.1 xref: EMBL:CAB53537.1 xref: EMBL:CAB55977.1 xref: EMBL:CAH71866.1 xref: EMBL:CAH71867.1 xref: EMBL:CAH72891.1 xref: EMBL:CAH72892.1 xref: EMBL:CAH73072.1 xref: EMBL:CAH73073.1 xref: EMBL:EAW77093.1 xref: EMBL:EAW77094.1 xref: UniProtKB:Q0VAA6 xref: UniProtKB:Q5VTI1 xref: UniProtKB:Q5VTI2 xref: UniProtKB:Q96QV3 xref: UniProtKB:Q9UFP5 xref: UniProtKB:Q9Y243 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004047 ! AKT3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007399 ! cdc37-akt3 physical interaction relationship: transforms_into CCO:B0010495 ! AKT3_HUMAN-Phosphoserine120 relationship: transforms_into CCO:B0010496 ! AKT3_HUMAN-Phosphoserine123 relationship: transforms_into CCO:B0010497 ! AKT3_HUMAN-Phosphothreonine305 relationship: transforms_into CCO:B0010498 ! AKT3_HUMAN-Phosphoserine472 [Term] id: CCO:B0005915 name: M3K4_HUMAN def: "Mitogen-activated protein kinase kinase kinase 4" [UniProtKB:Q9Y6R4] synonym: "EC 2.7.11.25" EXACT [UniProtKB:Q9Y6R4] synonym: "MAP three kinase 1" EXACT [UniProtKB:Q9Y6R4] synonym: "MAPK/ERK kinase kinase 4" EXACT [UniProtKB:Q9Y6R4] synonym: "MEK kinase 4" EXACT [UniProtKB:Q9Y6R4] synonym: "MEKK 4" EXACT [UniProtKB:Q9Y6R4] xref: EMBL:AAB68804.1 xref: EMBL:BAA13204.2 xref: UniProtKB:Q92612 xref: UniProtKB:Q9Y6R4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005008 ! MAP3K4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007408 ! map3k4-map2k61 physical interaction relationship: participates_in CCO:I0007530 ! map3k4-gadd45 physical interaction relationship: participates_in CCO:I0007531 ! map3k4-gadd45-2 physical interaction relationship: participates_in CCO:I0007532 ! map3k4-gadd45-3 physical interaction relationship: transforms_into CCO:B0012739 ! M3K4_HUMAN-Phosphoserine499 relationship: transforms_into CCO:B0012740 ! M3K4_HUMAN-Phosphothreonine1504 [Term] id: CCO:B0005916 name: EP400_HUMAN def: "E1A-binding protein p400" [UniProtKB:Q96L91] synonym: "CAG repeat protein 32" EXACT [UniProtKB:Q96L91] synonym: "Domino homolog" EXACT [UniProtKB:Q96L91] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q96L91] synonym: "hDomino" EXACT [UniProtKB:Q96L91] synonym: "p400 kDa SWI2/SNF2-related protein" EXACT [UniProtKB:Q96L91] synonym: "Trinucleotide repeat-containing gene 12 protein" EXACT [UniProtKB:Q96L91] xref: EMBL:AAB91441.1 xref: EMBL:AAH37208.1 xref: EMBL:AAH64554.1 xref: EMBL:AAK97789.1 xref: EMBL:BAA96022.1 xref: EMBL:BAB47447.1 xref: EMBL:BAC04759.1 xref: UniProtKB:O15411 xref: UniProtKB:Q6P2F5 xref: UniProtKB:Q8N8Q7 xref: UniProtKB:Q8NE05 xref: UniProtKB:Q96JK7 xref: UniProtKB:Q96L91 xref: UniProtKB:Q9P230 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004569 ! EP400_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007410 ! c20orf20-epc1-4 physical interaction relationship: transforms_into CCO:B0011712 ! EP400_HUMAN-Phosphoserine736 relationship: transforms_into CCO:B0011713 ! EP400_HUMAN-Phosphoserine755 relationship: transforms_into CCO:B0011714 ! EP400_HUMAN-Phosphoserine1547 [Term] id: CCO:B0005917 name: MO4L1_HUMAN def: "Mortality factor 4-like protein 1" [UniProtKB:Q9UBU8] synonym: "MORF-related gene 15 protein" EXACT [UniProtKB:Q9UBU8] synonym: "MSL3-1 protein" EXACT [UniProtKB:Q9UBU8] synonym: "Transcription factor-like protein MRG15" EXACT [UniProtKB:Q9UBU8] xref: EMBL:AAD20058.1 xref: EMBL:AAD20970.1 xref: EMBL:AAD29872.1 xref: EMBL:AAF29033.1 xref: EMBL:AAF80854.1 xref: EMBL:AAG17253.1 xref: EMBL:AAH02936.1 xref: EMBL:AAH22845.1 xref: EMBL:AAH67826.1 xref: EMBL:AAN65338.1 xref: EMBL:AAQ13497.1 xref: EMBL:CAB70879.2 xref: UniProtKB:O95899 xref: UniProtKB:Q5QTS1 xref: UniProtKB:Q6NVX8 xref: UniProtKB:Q86YT7 xref: UniProtKB:Q9HBP6 xref: UniProtKB:Q9NSW5 xref: UniProtKB:Q9UBU8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005108 ! MORF4L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007410 ! c20orf20-epc1-4 physical interaction [Term] id: CCO:B0005918 name: TPD55_HUMAN def: "Tumor protein D55" [UniProtKB:Q96J77] synonym: "hD55" EXACT [UniProtKB:Q96J77] synonym: "Testis development protein NYD-SP25" EXACT [UniProtKB:Q96J77] synonym: "Tumor protein D52-like 3" EXACT [UniProtKB:Q96J77] xref: EMBL:AAH17589.1 xref: EMBL:AAH33792.1 xref: EMBL:AAH42113.1 xref: EMBL:AAK66820.1 xref: EMBL:BAB71505.1 xref: EMBL:CAI13289.1 xref: EMBL:CAI13290.1 xref: EMBL:CAI13291.1 xref: UniProtKB:Q5TCR3 xref: UniProtKB:Q5TCR4 xref: UniProtKB:Q5TCR5 xref: UniProtKB:Q8N4P5 xref: UniProtKB:Q8WWF7 xref: UniProtKB:Q96J77 xref: UniProtKB:Q96M09 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005818 ! TPD52L3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007413 ! nyd_sp25-tpd53 physical interaction [Term] id: CCO:B0005919 name: RMI1_HUMAN def: "Protein RMI1 homolog" [UniProtKB:Q9H9A7] synonym: "75 kDa BLM-associated protein" EXACT [UniProtKB:Q9H9A7] synonym: "BLAP75" EXACT [UniProtKB:Q9H9A7] synonym: "FAAP75" EXACT [UniProtKB:Q9H9A7] xref: EMBL:AAH39999.1 xref: EMBL:AAH53549.1 xref: EMBL:AAH64937.1 xref: EMBL:BAB14325.1 xref: EMBL:CAI13575.1 xref: EMBL:CAI13576.1 xref: UniProtKB:Q5SQG8 xref: UniProtKB:Q5SQG9 xref: UniProtKB:Q6P1Q4 xref: UniProtKB:Q6PI89 xref: UniProtKB:Q7Z6L6 xref: UniProtKB:Q9H9A7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005516 ! RMI1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007422 ! blm-c9orf76-2 physical interaction relationship: participates_in CCO:I0007427 ! c9orf76-blm-2 physical interaction relationship: participates_in CCO:I0007748 ! c9orf76-blm-1 physical interaction relationship: participates_in CCO:I0007749 ! blm-c9orf76-1 physical interaction relationship: participates_in CCO:I0008561 ! c9orf76-blm-4 colocalization relationship: participates_in CCO:I0008565 ! c9orf76-blm-3 physical interaction relationship: transforms_into CCO:B0013907 ! RMI1_HUMAN-Phosphoserine292 [Term] id: CCO:B0005920 name: FGFR3_HUMAN def: "Fibroblast growth factor receptor 3 precursor" [UniProtKB:P22607] synonym: "CD333 antigen" EXACT [UniProtKB:P22607] synonym: "EC 2.7.10.1" EXACT [UniProtKB:P22607] synonym: "FGFR-3" EXACT [UniProtKB:P22607] xref: EMBL:AAA52450.1 xref: EMBL:AAA58470.1 xref: EMBL:AAA63209.1 xref: EMBL:AAA67781.1 xref: EMBL:AAB33323.1 xref: EMBL:AAF63380.1 xref: EMBL:AAU89726.1 xref: EMBL:CAA59334.1 xref: UniProtKB:P22607 xref: UniProtKB:Q14308 xref: UniProtKB:Q16294 xref: UniProtKB:Q16608 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004644 ! FGFR3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008232 ! fgfr3-centd2 physical interaction relationship: participates_in CCO:I0008387 ! fgfr3-flj22624 physical interaction relationship: transforms_into CCO:B0011880 ! FGFR3_HUMAN-Phosphotyrosine648 relationship: transforms_into CCO:B0031317 ! FGFR3_HUMAN-Phosphotyrosine647 [Term] id: CCO:B0005921 name: IGHA1_HUMAN def: "Ig alpha-1 chain C region" [UniProtKB:P01876] xref: EMBL:AAC82528.1 xref: UniProtKB:P01876 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004869 ! IGHA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007447 ! apc-ctbb1 physical interaction [Term] id: CCO:B0005922 name: K1C9_HUMAN def: "Keratin, type I cytoskeletal 9" [UniProtKB:P35527] synonym: "CK-9" EXACT [UniProtKB:P35527] synonym: "Cytokeratin-9" EXACT [UniProtKB:P35527] synonym: "K9" EXACT [UniProtKB:P35527] synonym: "Keratin-9" EXACT [UniProtKB:P35527] xref: EMBL:AAC60619.1 xref: EMBL:AAI21171.1 xref: EMBL:BAA19418.1 xref: EMBL:CAA52924.1 xref: EMBL:CAA82315.1 xref: UniProtKB:O00109 xref: UniProtKB:P35527 xref: UniProtKB:Q0IJ47 xref: UniProtKB:Q14665 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004924 ! KRT9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007447 ! apc-ctbb1 physical interaction [Term] id: CCO:B0005923 name: BMX_HUMAN def: "Cytoplasmic tyrosine-protein kinase BMX" [UniProtKB:P51813] synonym: "Bone marrow tyrosine kinase gene in chromosome X protein" EXACT [UniProtKB:P51813] synonym: "EC 2.7.10.2" EXACT [UniProtKB:P51813] synonym: "Epithelial and endothelial tyrosine kinase" EXACT [UniProtKB:P51813] synonym: "ETK" EXACT [UniProtKB:P51813] synonym: "NTK38" EXACT [UniProtKB:P51813] xref: EMBL:AAA17744.1 xref: EMBL:AAC08966.1 xref: EMBL:AAH16652.1 xref: EMBL:CAA58169.1 xref: EMBL:EAW98889.1 xref: UniProtKB:A6NIH9 xref: UniProtKB:O60564 xref: UniProtKB:P51813 xref: UniProtKB:Q12871 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004175 ! BMX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007449 ! bmx-tp53-1 physical interaction relationship: transforms_into CCO:B0010815 ! BMX_HUMAN-Phosphotyrosine566 [Term] id: CCO:B0005924 name: GAB2_HUMAN def: "GRB2-associated-binding protein 2" [UniProtKB:Q9UQC2] synonym: "GRB2-associated binder 2" EXACT [UniProtKB:Q9UQC2] synonym: "Growth factor receptor bound protein 2-associated protein 2" EXACT [UniProtKB:Q9UQC2] synonym: "pp100" EXACT [UniProtKB:Q9UQC2] xref: EMBL:BAA25497.2 xref: EMBL:BAA76737.1 xref: UniProtKB:O60317 xref: UniProtKB:Q9UQC2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004677 ! GAB2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007453 ! gab2-grb2-1 physical interaction relationship: transforms_into CCO:B0011917 ! GAB2_HUMAN-Phosphotyrosine266 relationship: transforms_into CCO:B0011918 ! GAB2_HUMAN-Phosphoserine405 relationship: transforms_into CCO:B0031324 ! GAB2_HUMAN-Phosphoserine264 relationship: transforms_into CCO:B0031325 ! GAB2_HUMAN-Phosphothreonine265 relationship: transforms_into CCO:B0031326 ! GAB2_HUMAN-Phosphotyrosine293 [Term] id: CCO:B0005925 name: SMCA2_HUMAN def: "Probable global transcription activator SNF2L2" [UniProtKB:P51531] synonym: "ATP-dependent helicase SMARCA2" EXACT [UniProtKB:P51531] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P51531] synonym: "hBRM" EXACT [UniProtKB:P51531] synonym: "SNF2-alpha" EXACT [UniProtKB:P51531] synonym: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2" EXACT [UniProtKB:P51531] xref: EMBL:BAA05142.1 xref: EMBL:CAA51407.1 xref: UniProtKB:P51531 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005630 ! SMARCA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007477 ! smarca2-sam68 physical interaction relationship: participates_in CCO:I0007512 ! smarca2-sam68-1 physical interaction relationship: transforms_into CCO:B0014086 ! SMCA2_HUMAN-Phosphoserine325 relationship: transforms_into CCO:B0014087 ! SMCA2_HUMAN-Phosphoserine587 relationship: transforms_into CCO:B0014088 ! SMCA2_HUMAN-Phosphoserine952 relationship: transforms_into CCO:B0014089 ! SMCA2_HUMAN-Phosphoserine1373 relationship: transforms_into CCO:B0014090 ! SMCA2_HUMAN-Phosphoserine1406 relationship: transforms_into CCO:B0014091 ! SMCA2_HUMAN-Phosphoserine1414 relationship: transforms_into CCO:B0014092 ! SMCA2_HUMAN-Phosphoserine1415 relationship: transforms_into CCO:B0014093 ! SMCA2_HUMAN-N6-acetyllysine1547 relationship: transforms_into CCO:B0014094 ! SMCA2_HUMAN-N6-acetyllysine1549 relationship: transforms_into CCO:B0014095 ! SMCA2_HUMAN-N6-acetyllysine1551 relationship: transforms_into CCO:B0014096 ! SMCA2_HUMAN-Phosphoserine1564 relationship: transforms_into CCO:B0014097 ! SMCA2_HUMAN-Phosphoserine1568 [Term] id: CCO:B0005926 name: NDEL1_HUMAN def: "Nuclear distribution protein nudE-like 1" [UniProtKB:Q9GZM8] synonym: "Mitosin-associated protein 1" EXACT [UniProtKB:Q9GZM8] synonym: "Protein Nudel" EXACT [UniProtKB:Q9GZM8] xref: EMBL:AAF24516.3 xref: EMBL:AAF97497.1 xref: EMBL:AAG43425.1 xref: EMBL:AAH26101.1 xref: EMBL:CAD89957.3 xref: UniProtKB:Q86T80 xref: UniProtKB:Q8TAR7 xref: UniProtKB:Q9GZM8 xref: UniProtKB:Q9UH50 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005164 ! NDEL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007489 ! ndel1_pafah1b1_1 physical interaction relationship: participates_in CCO:I0007490 ! pafah1b1_ndel1_1 physical interaction relationship: transforms_into CCO:B0013135 ! NDEL1_HUMAN-Phosphoserine215 relationship: transforms_into CCO:B0013136 ! NDEL1_HUMAN-Phosphothreonine219 relationship: transforms_into CCO:B0013137 ! NDEL1_HUMAN-Phosphoserine242 relationship: transforms_into CCO:B0013138 ! NDEL1_HUMAN-Phosphothreonine245 [Term] id: CCO:B0005927 name: H33_HUMAN def: "Histone H3.3" [UniProtKB:P84243] xref: EMBL:AAA52653.1 xref: EMBL:AAA52654.1 xref: EMBL:AAG17271.1 xref: EMBL:AAH01124.1 xref: EMBL:AAH06497.1 xref: EMBL:AAH12813.1 xref: EMBL:AAH17558.1 xref: EMBL:AAH29405.1 xref: EMBL:AAH38989.1 xref: EMBL:AAH66901.1 xref: EMBL:AAH67757.1 xref: EMBL:AAH81560.1 xref: EMBL:AAH81561.1 xref: EMBL:AAH95447.1 xref: EMBL:AAI08702.1 xref: EMBL:CAA29288.1 xref: EMBL:CAA88778.1 xref: EMBL:CAD97621.1 xref: EMBL:CAH73371.1 xref: EMBL:CAH73372.1 xref: UniProtKB:P06351 xref: UniProtKB:P33155 xref: UniProtKB:P84243 xref: UniProtKB:Q5VV55 xref: UniProtKB:Q5VV56 xref: UniProtKB:Q66I33 xref: UniProtKB:Q9V3W4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004761 ! H3F3A_human relationship: encoded_by CCO:G0004762 ! H3F3B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007514 ! h3_peptide-cul4a physical interaction relationship: transforms_into CCO:B0012096 ! H33_HUMAN-Phosphothreonine4 relationship: transforms_into CCO:B0012097 ! H33_HUMAN-N6-acetyllysine5 relationship: transforms_into CCO:B0012098 ! H33_HUMAN-N6-methyllysine5 relationship: transforms_into CCO:B0012099 ! H33_HUMAN-Citrulline9 relationship: transforms_into CCO:B0012100 ! H33_HUMAN-dimethylarginine9 relationship: transforms_into CCO:B0012101 ! H33_HUMAN-N6,N6,N6-trimethyllysine10 relationship: transforms_into CCO:B0012102 ! H33_HUMAN-N6,N6-dimethyllysine10 relationship: transforms_into CCO:B0012103 ! H33_HUMAN-N6-acetyllysine10 relationship: transforms_into CCO:B0012104 ! H33_HUMAN-N6-methyllysine10 relationship: transforms_into CCO:B0012105 ! H33_HUMAN-Phosphoserine11 relationship: transforms_into CCO:B0012106 ! H33_HUMAN-Phosphothreonine12 relationship: transforms_into CCO:B0012107 ! H33_HUMAN-N6-acetyllysine15 relationship: transforms_into CCO:B0012108 ! H33_HUMAN-dimethylarginine18 relationship: transforms_into CCO:B0012109 ! H33_HUMAN-Citrulline18 relationship: transforms_into CCO:B0012110 ! H33_HUMAN-N6-acetyllysine19 relationship: transforms_into CCO:B0012111 ! H33_HUMAN-N6-methyllysine19 relationship: transforms_into CCO:B0012112 ! H33_HUMAN-N6-acetyllysine24 relationship: transforms_into CCO:B0012113 ! H33_HUMAN-N6-methyllysine24 relationship: transforms_into CCO:B0012114 ! H33_HUMAN-N6,N6,N6-trimethyllysine28 relationship: transforms_into CCO:B0012115 ! H33_HUMAN-N6,N6-dimethyllysine28 relationship: transforms_into CCO:B0012116 ! H33_HUMAN-N6-acetyllysine28 relationship: transforms_into CCO:B0012117 ! H33_HUMAN-N6-methyllysine28 relationship: transforms_into CCO:B0012118 ! H33_HUMAN-Phosphoserine29 relationship: transforms_into CCO:B0012119 ! H33_HUMAN-Phosphoserine32 relationship: transforms_into CCO:B0012120 ! H33_HUMAN-N6,N6,N6-trimethyllysine37 relationship: transforms_into CCO:B0012121 ! H33_HUMAN-N6,N6-dimethyllysine37 relationship: transforms_into CCO:B0012122 ! H33_HUMAN-N6-acetyllysine37 relationship: transforms_into CCO:B0012123 ! H33_HUMAN-N6-methyllysine37 relationship: transforms_into CCO:B0012124 ! H33_HUMAN-N6,N6,N6-trimethyllysine57 relationship: transforms_into CCO:B0012125 ! H33_HUMAN-N6-acetyllysine57 relationship: transforms_into CCO:B0012126 ! H33_HUMAN-N6-methyllysine57 relationship: transforms_into CCO:B0012127 ! H33_HUMAN-N6-methyllysine65 relationship: transforms_into CCO:B0012128 ! H33_HUMAN-N6,N6,N6-trimethyllysine80 relationship: transforms_into CCO:B0012129 ! H33_HUMAN-N6,N6-dimethyllysine80 relationship: transforms_into CCO:B0012130 ! H33_HUMAN-N6-acetyllysine80 relationship: transforms_into CCO:B0012131 ! H33_HUMAN-N6-methyllysine80 relationship: transforms_into CCO:B0012132 ! H33_HUMAN-N6-methyllysine123 [Term] id: CCO:B0005929 name: HMGB1_HUMAN def: "High mobility group protein B1" [UniProtKB:P09429] synonym: "High mobility group protein 1" EXACT [UniProtKB:P09429] synonym: "HMG-1" EXACT [UniProtKB:P09429] xref: EMBL:AAB08987.1 xref: EMBL:AAH03378.1 xref: EMBL:AAH30981.1 xref: EMBL:AAH66889.1 xref: EMBL:AAH67732.1 xref: EMBL:AAP35586.1 xref: EMBL:AAQ91389.1 xref: EMBL:AAV38961.1 xref: EMBL:CAA31110.1 xref: EMBL:CAG33144.1 xref: EMBL:CAH18408.1 xref: UniProtKB:P09429 xref: UniProtKB:Q6IBE1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004812 ! HMGB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007526 ! hmgb1-tp73-1 physical interaction relationship: participates_in CCO:I0007949 ! tp53-hmgb1 physical interaction relationship: participates_in CCO:I0008119 ! hmgb1-rif1 physical interaction relationship: transforms_into CCO:B0012197 ! HMGB1_HUMAN-N6-acetyllysine30 relationship: transforms_into CCO:B0012198 ! HMGB1_HUMAN-Phosphoserine35 [Term] id: CCO:B0005931 name: IMA3_HUMAN def: "Importin subunit alpha-3" [UniProtKB:O00505] synonym: "Karyopherin subunit alpha-3" EXACT [UniProtKB:O00505] synonym: "SRP1-gamma" EXACT [UniProtKB:O00505] xref: EMBL:AAB87693.1 xref: EMBL:AAH17355.1 xref: EMBL:AAH24202.1 xref: EMBL:BAA20378.1 xref: EMBL:CAA73026.1 xref: UniProtKB:O00191 xref: UniProtKB:O00505 xref: UniProtKB:O43195 xref: UniProtKB:Q96AA7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004887 ! KPNA3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007556 ! cdn1b-kpna3-1 physical interaction relationship: participates_in CCO:I0007557 ! cdn1b-kpna3-2 physical interaction relationship: participates_in CCO:I0007861 ! cdn1b-kpna3-3 physical interaction relationship: participates_in CCO:I0007862 ! cdn1b-kpna5-5 physical interaction relationship: transforms_into CCO:B0012378 ! IMA3_HUMAN-Phosphoserine60 [Term] id: CCO:B0005932 name: UBL5_HUMAN def: "Ubiquitin-like protein 5" [UniProtKB:Q9BZL1] xref: EMBL:AAH07053.1 xref: EMBL:AAI10840.1 xref: EMBL:AAK14178.1 xref: EMBL:AAP36019.1 xref: UniProtKB:Q2NL89 xref: UniProtKB:Q9BZL1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005867 ! UBL5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007564 ! ubl5-sart1-1 physical interaction [Term] id: CCO:B0005933 name: BTBD2_HUMAN def: "BTB/POZ domain-containing protein 2" [UniProtKB:Q9BX70] xref: EMBL:AAC16070.1 xref: EMBL:AAC26984.1 xref: EMBL:AAG45443.1 xref: EMBL:AAH00564.2 xref: EMBL:AAH08035.2 xref: EMBL:AAH53986.1 xref: EMBL:AAH94820.1 xref: EMBL:AAK25826.1 xref: EMBL:BAA91136.1 xref: EMBL:BAB55143.1 xref: EMBL:CAB96527.1 xref: EMBL:CAG33511.1 xref: UniProtKB:O60418 xref: UniProtKB:O75248 xref: UniProtKB:Q4VBZ1 xref: UniProtKB:Q6IAC5 xref: UniProtKB:Q7Z5W0 xref: UniProtKB:Q96SX8 xref: UniProtKB:Q9BX70 xref: UniProtKB:Q9NPS1 xref: UniProtKB:Q9NX81 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004193 ! BTBD2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007577 ! tp53-btbd2-1 physical interaction relationship: participates_in CCO:I0007999 ! btbd2-tp53 physical interaction [Term] id: CCO:B0005934 name: WNK4_HUMAN def: "Serine/threonine-protein kinase WNK4" [UniProtKB:Q96J92] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q96J92] synonym: "Protein kinase with no lysine 4" EXACT [UniProtKB:Q96J92] synonym: "Protein kinase, lysine-deficient 4" EXACT [UniProtKB:Q96J92] xref: EMBL:AAK91995.1 xref: EMBL:BAC04669.1 xref: EMBL:BAC04688.1 xref: EMBL:CAC32991.1 xref: EMBL:CAC48387.1 xref: UniProtKB:Q8N8X3 xref: UniProtKB:Q8N8Z2 xref: UniProtKB:Q96DT8 xref: UniProtKB:Q96J92 xref: UniProtKB:Q9BYS5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005931 ! WNK4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007582 ! bcl6-hdac4 physical interaction relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0014695 ! WNK4_HUMAN-Phosphoserine331 relationship: transforms_into CCO:B0014696 ! WNK4_HUMAN-Phosphoserine335 [Term] id: CCO:B0005935 name: PKCB1_HUMAN def: "Protein kinase C-binding protein 1" [UniProtKB:Q9ULU4] synonym: "CTCL tumor antigen se14-3" EXACT [UniProtKB:Q9ULU4] synonym: "Cutaneous T-cell lymphoma-associated antigen se14-3" EXACT [UniProtKB:Q9ULU4] synonym: "Rack7" EXACT [UniProtKB:Q9ULU4] synonym: "Zinc finger MYND domain-containing protein 8" EXACT [UniProtKB:Q9ULU4] xref: EMBL:AAC72244.1 xref: EMBL:AAF71262.1 xref: EMBL:AAG34905.1 xref: EMBL:AAH30721.2 xref: EMBL:AAL50790.1 xref: EMBL:AAY85630.1 xref: EMBL:AAY85631.1 xref: EMBL:BAA86439.1 xref: EMBL:CAE46008.1 xref: EMBL:CAI20089.1 xref: EMBL:CAI21842.1 xref: EMBL:CAI23169.1 xref: UniProtKB:Q13517 xref: UniProtKB:Q4JJ94 xref: UniProtKB:Q4JJ95 xref: UniProtKB:Q5TH09 xref: UniProtKB:Q6MZM1 xref: UniProtKB:Q8WXC5 xref: UniProtKB:Q9H1F3 xref: UniProtKB:Q9H1F4 xref: UniProtKB:Q9H1F5 xref: UniProtKB:Q9H1L8 xref: UniProtKB:Q9H1L9 xref: UniProtKB:Q9H2G5 xref: UniProtKB:Q9NYN3 xref: UniProtKB:Q9UIX6 xref: UniProtKB:Q9ULU4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005323 ! ZMYND8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007582 ! bcl6-hdac4 physical interaction relationship: participates_in CCO:I0007584 ! pkc-bcl6 physical interaction relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0013534 ! PKCB1_HUMAN-Phosphoserine486 relationship: transforms_into CCO:B0013535 ! PKCB1_HUMAN-Phosphoserine490 relationship: transforms_into CCO:B0013536 ! PKCB1_HUMAN-Phosphoserine547 relationship: transforms_into CCO:B0013537 ! PKCB1_HUMAN-Phosphoserine652 relationship: transforms_into CCO:B0013538 ! PKCB1_HUMAN-Phosphoserine668 relationship: transforms_into CCO:B0013539 ! PKCB1_HUMAN-Phosphoserine1086 [Term] id: CCO:B0005936 name: FANCF_HUMAN def: "Fanconi anemia group F protein" [UniProtKB:Q9NPI8] synonym: "Protein FACF" EXACT [UniProtKB:Q9NPI8] xref: EMBL:AAF26297.1 xref: EMBL:AAF26298.1 xref: EMBL:AAH47028.1 xref: EMBL:AAH93867.1 xref: EMBL:AAI01808.1 xref: EMBL:AAX09677.1 xref: EMBL:BAB14433.1 xref: UniProtKB:Q52LM0 xref: UniProtKB:Q9NPI8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004610 ! FANCF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007587 ! fancg-fancf-1 physical interaction [Term] id: CCO:B0005937 name: TAF10_HUMAN def: "Transcription initiation factor TFIID subunit 10" [UniProtKB:Q12962] synonym: "STAF28" EXACT [UniProtKB:Q12962] synonym: "TAF(II)30" EXACT [UniProtKB:Q12962] synonym: "TAFII-30" EXACT [UniProtKB:Q12962] synonym: "TAFII30" EXACT [UniProtKB:Q12962] synonym: "Transcription initiation factor TFIID 30 kDa subunit" EXACT [UniProtKB:Q12962] xref: EMBL:AAA62230.1 xref: EMBL:AAB61242.1 xref: EMBL:AAH12088.1 xref: EMBL:AAM14627.1 xref: UniProtKB:O00703 xref: UniProtKB:Q12962 xref: UniProtKB:Q13175 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005724 ! TAF10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction relationship: transforms_into CCO:B0032858 ! TAF10_HUMAN-N6-methyllysine189 [Term] id: CCO:B0005938 name: TAF9_HUMAN def: "Transcription initiation factor TFIID subunit 9" [UniProtKB:Q16594] synonym: "RNA polymerase II TBP-associated factor subunit G" EXACT [UniProtKB:Q16594] synonym: "STAF31/32" EXACT [UniProtKB:Q16594] synonym: "TAFII-31" EXACT [UniProtKB:Q16594] synonym: "TAFII-32" EXACT [UniProtKB:Q16594] synonym: "TAFII32" EXACT [UniProtKB:Q16594] synonym: "Transcription initiation factor TFIID 31 kDa subunit" EXACT [UniProtKB:Q16594] xref: EMBL:AAA84389.1 xref: EMBL:AAA91318.1 xref: EMBL:AAC50153.1 xref: EMBL:AAH03400.1 xref: EMBL:AAH33320.1 xref: EMBL:AAN84793.1 xref: EMBL:AAV38458.1 xref: UniProtKB:Q16594 xref: UniProtKB:Q5U0D1 xref: UniProtKB:Q9BTS1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005727 ! TAF9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction relationship: transforms_into CCO:B0014307 ! TAF9_HUMAN-Phosphoserine85 [Term] id: CCO:B0005940 name: Q9UC27_HUMAN def: "94 kDa epididymal cytokeratin-like protein" [UniProtKB:Q9UC27] xref: UniProtKB:Q9UC27 is_a: CCO:U0000007 ! cell cycle protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007598 ! skp2-skp1 physical interaction [Term] id: CCO:B0005941 name: FBW1B_HUMAN def: "F-box/WD repeat-containing protein 11" [UniProtKB:Q9UKB1] synonym: "F-box and WD repeats protein beta-TrCP2" EXACT [UniProtKB:Q9UKB1] synonym: "F-box/WD repeat-containing protein 1B" EXACT [UniProtKB:Q9UKB1] synonym: "Homologous to Slimb protein" EXACT [UniProtKB:Q9UKB1] synonym: "HOS" EXACT [UniProtKB:Q9UKB1] xref: EMBL:AAF04528.1 xref: EMBL:AAH26213.1 xref: EMBL:BAA31671.1 xref: EMBL:BAA92329.1 xref: EMBL:BAA92330.1 xref: EMBL:BAA92331.1 xref: UniProtKB:Q9P2S8 xref: UniProtKB:Q9P2S9 xref: UniProtKB:Q9UKB1 xref: UniProtKB:Q9Y4C6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004620 ! FBXW11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007599 ! fbxw11-skp1 physical interaction relationship: participates_in CCO:I0007602 ! fbxw11-wee1 physical interaction [Term] id: CCO:B0005943 name: APTX_HUMAN def: "Aprataxin" [UniProtKB:Q7Z2E3] synonym: "EC 3.-.-.-" EXACT [UniProtKB:Q7Z2E3] synonym: "FHA-HIT" EXACT [UniProtKB:Q7Z2E3] synonym: "Forkhead-associated domain histidine triad-like protein" EXACT [UniProtKB:Q7Z2E3] xref: EMBL:AAH01628.1 xref: EMBL:AAK91768.1 xref: EMBL:AAP86319.1 xref: EMBL:AAP86320.1 xref: EMBL:AAP86321.1 xref: EMBL:AAP86322.1 xref: EMBL:AAP86323.1 xref: EMBL:AAP86324.1 xref: EMBL:AAP86325.1 xref: EMBL:AAP86326.1 xref: EMBL:AAP86327.1 xref: EMBL:AAP86328.1 xref: EMBL:AAP86329.1 xref: EMBL:AAP86330.1 xref: EMBL:AAP86331.1 xref: EMBL:AAP86332.1 xref: EMBL:BAA90985.1 xref: EMBL:CAD92454.1 xref: EMBL:CAD92455.1 xref: EMBL:CAD92456.1 xref: EMBL:CAD92457.1 xref: EMBL:CAD92458.1 xref: EMBL:CAD92459.1 xref: EMBL:CAD98041.1 xref: EMBL:CAE01427.1 xref: EMBL:CAI15734.1 xref: UniProtKB:Q5T781 xref: UniProtKB:Q7Z2E3 xref: UniProtKB:Q7Z2F3 xref: UniProtKB:Q7Z336 xref: UniProtKB:Q7Z5R5 xref: UniProtKB:Q7Z6V7 xref: UniProtKB:Q7Z6V8 xref: UniProtKB:Q9NXM5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004086 ! APTX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007613 ! aptx-cntrob physical interaction [Term] id: CCO:B0005944 name: ATN1_HUMAN def: "Atrophin-1" [UniProtKB:P54259] synonym: "Dentatorubral-pallidoluysian atrophy protein" EXACT [UniProtKB:P54259] xref: EMBL:AAB50276.1 xref: EMBL:AAB51321.1 xref: EMBL:BAA06626.1 xref: EMBL:BAA07534.1 xref: EMBL:BAA23631.1 xref: UniProtKB:P54259 xref: UniProtKB:Q99495 xref: UniProtKB:Q99621 xref: UniProtKB:Q9UEK7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004118 ! ATN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007614 ! atn1-jag2 physical interaction relationship: participates_in CCO:I0007615 ! atn1-jag2-1 physical interaction relationship: participates_in CCO:I0007616 ! atn1-siah1 physical interaction relationship: participates_in CCO:I0007617 ! atn1-siah2 physical interaction relationship: participates_in CCO:I0007618 ! atn1-spag5 physical interaction relationship: participates_in CCO:I0008764 ! atn1-psme3-2 physical interaction relationship: participates_in CCO:I0008781 ! atn1-psme3 physical interaction relationship: participates_in CCO:I0008782 ! atn1-psma3 physical interaction relationship: participates_in CCO:I0008783 ! atn1-psme3-1 physical interaction relationship: participates_in CCO:I0008784 ! atn1-psma3-1 physical interaction relationship: transforms_into CCO:B0010660 ! ATN1_HUMAN-Phosphoserine34 relationship: transforms_into CCO:B0010661 ! ATN1_HUMAN-Phosphoserine77 relationship: transforms_into CCO:B0010662 ! ATN1_HUMAN-Phosphoserine79 relationship: transforms_into CCO:B0010663 ! ATN1_HUMAN-Phosphoserine101 relationship: transforms_into CCO:B0010664 ! ATN1_HUMAN-Phosphoserine103 relationship: transforms_into CCO:B0010665 ! ATN1_HUMAN-Phosphoserine107 relationship: transforms_into CCO:B0010666 ! ATN1_HUMAN-Phosphoserine112 relationship: transforms_into CCO:B0010667 ! ATN1_HUMAN-Phosphoserine119 relationship: transforms_into CCO:B0010668 ! ATN1_HUMAN-Phosphoserine627 relationship: transforms_into CCO:B0010669 ! ATN1_HUMAN-Phosphoserine640 relationship: transforms_into CCO:B0010670 ! ATN1_HUMAN-Phosphothreonine648 relationship: transforms_into CCO:B0010671 ! ATN1_HUMAN-Phosphoserine656 relationship: transforms_into CCO:B0010672 ! ATN1_HUMAN-Phosphothreonine664 relationship: transforms_into CCO:B0010673 ! ATN1_HUMAN-Phosphoserine734 relationship: transforms_into CCO:B0010674 ! ATN1_HUMAN-Phosphoserine741 relationship: transforms_into CCO:B0010675 ! ATN1_HUMAN-Phosphoserine743 [Term] id: CCO:B0005945 name: ATX7_HUMAN def: "Ataxin-7" [UniProtKB:O15265] synonym: "Spinocerebellar ataxia type 7 protein" EXACT [UniProtKB:O15265] xref: EMBL:AAC19162.1 xref: EMBL:AAC19163.1 xref: EMBL:AAC39765.1 xref: EMBL:CAA04154.1 xref: UniProtKB:O15265 xref: UniProtKB:O75328 xref: UniProtKB:O75329 xref: UniProtKB:Q9Y6P8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004128 ! ATXN7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007626 ! atxn7-tp53bp2 physical interaction relationship: transforms_into CCO:B0010719 ! ATX7_HUMAN-Phosphoserine840 relationship: transforms_into CCO:B0010720 ! ATX7_HUMAN-Phosphoserine849 relationship: transforms_into CCO:B0010721 ! ATX7_HUMAN-Phosphothreonine854 [Term] id: CCO:B0005946 name: Q8IY68_HUMAN def: "Ataxin-7-like protein 3" [UniProtKB:Q8IY68] xref: EMBL:AAH37418.1 xref: UniProtKB:Q8IY68 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006019 ! ATXN7L3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007627 ! atxn7l3-sertad1 physical interaction [Term] id: CCO:B0005947 name: PICK1_HUMAN def: "PRKCA-binding protein" [UniProtKB:Q9NRD5] synonym: "Protein interacting with C kinase 1" EXACT [UniProtKB:Q9NRD5] synonym: "Protein kinase C-alpha-binding protein" EXACT [UniProtKB:Q9NRD5] xref: EMBL:AAF97502.1 xref: EMBL:AAH17561.1 xref: EMBL:BAA89294.1 xref: EMBL:CAB37478.1 xref: EMBL:CAB41082.1 xref: EMBL:CAG30436.1 xref: UniProtKB:O95906 xref: UniProtKB:Q9NRD5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005313 ! PICK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007629 ! gfi1-prkcabp physical interaction relationship: participates_in CCO:I0007671 ! gfi1b-prkcabp physical interaction relationship: participates_in CCO:I0007690 ! gfi1b-prkcabp-1 physical interaction [Term] id: CCO:B0005948 name: ACTN1_HUMAN def: "Alpha-actinin-1" [UniProtKB:P12814] synonym: "Alpha-actinin cytoskeletal isoform" EXACT [UniProtKB:P12814] synonym: "F-actin cross-linking protein" EXACT [UniProtKB:P12814] synonym: "Non-muscle alpha-actinin-1" EXACT [UniProtKB:P12814] xref: EMBL:AAA51582.1 xref: EMBL:AAH03576.1 xref: EMBL:AAH15766.1 xref: EMBL:AAP35871.1 xref: EMBL:CAA33803.1 xref: EMBL:CAA38970.1 xref: UniProtKB:P12814 xref: UniProtKB:Q9BTN1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004021 ! ACTN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007630 ! gfi1b-actn1 physical interaction relationship: participates_in CCO:I0007682 ! gfi1b-actn1-1 physical interaction relationship: transforms_into CCO:B0010446 ! ACTN1_HUMAN-Phosphotyrosine12 relationship: transforms_into CCO:B0010447 ! ACTN1_HUMAN-Phosphothreonine50 relationship: transforms_into CCO:B0010448 ! ACTN1_HUMAN-Phosphoserine140 [Term] id: CCO:B0005949 name: AGRIN_HUMAN def: "Agrin precursor" [UniProtKB:O00468] xref: EMBL:AAB52917.1 xref: EMBL:AAC39776.1 xref: EMBL:AAH04220.2 xref: EMBL:AAH07649.1 xref: EMBL:AAH34009.1 xref: EMBL:AAH63620.1 xref: EMBL:BAD52440.1 xref: EMBL:CAI15575.2 xref: UniProtKB:O00468 xref: UniProtKB:Q5SVA2 xref: UniProtKB:Q60FE1 xref: UniProtKB:Q7KYS8 xref: UniProtKB:Q8N4J5 xref: UniProtKB:Q96IC1 xref: UniProtKB:Q9BTD4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006344 ! AGRN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007631 ! gfi1b-agrn physical interaction [Term] id: CCO:B0005950 name: BECN1_HUMAN def: "Beclin-1" [UniProtKB:Q14457] synonym: "Coiled-coil myosin-like BCL2-interacting protein" EXACT [UniProtKB:Q14457] synonym: "Protein GT197" EXACT [UniProtKB:Q14457] xref: EMBL:AAB59573.1 xref: EMBL:AAC68653.1 xref: EMBL:AAD27650.1 xref: EMBL:AAH10276.1 xref: UniProtKB:O75595 xref: UniProtKB:Q14457 xref: UniProtKB:Q9UNA8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004157 ! BECN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007632 ! gfi1b-becn1 physical interaction [Term] id: CCO:B0005951 name: BRE_HUMAN def: "Protein BRE" [UniProtKB:Q9NXR7] synonym: "Brain and reproductive organ-expressed protein" EXACT [UniProtKB:Q9NXR7] synonym: "BRCA1/BRCA2-containing complex subunit 45" EXACT [UniProtKB:Q9NXR7] xref: EMBL:AAA64231.1 xref: EMBL:AAB69387.1 xref: EMBL:AAH01251.1 xref: EMBL:AAL17818.1 xref: EMBL:AAR30499.1 xref: EMBL:BAA90943.1 xref: UniProtKB:Q13880 xref: UniProtKB:Q96P06 xref: UniProtKB:Q9NXR7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004190 ! BRE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007634 ! gfi1b-bre physical interaction [Term] id: CCO:B0005952 name: CT012_HUMAN def: "Ankyrin repeat-containing protein C20orf12" [UniProtKB:Q9NVP4] xref: EMBL:AAZ13595.1 xref: EMBL:BAA91706.1 xref: EMBL:BAB70949.1 xref: EMBL:BAD18596.1 xref: EMBL:CAH18182.1 xref: EMBL:CAI12510.1 xref: EMBL:CAI12511.1 xref: EMBL:CAI21830.1 xref: EMBL:CAI21831.1 xref: UniProtKB:Q4F7X1 xref: UniProtKB:Q5QPD9 xref: UniProtKB:Q5QPE0 xref: UniProtKB:Q68DN8 xref: UniProtKB:Q6ZMX9 xref: UniProtKB:Q96NF0 xref: UniProtKB:Q9H1E0 xref: UniProtKB:Q9H442 xref: UniProtKB:Q9NVP4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004411 ! C20orf12_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007635 ! gfi1b-c20orf12 physical interaction [Term] id: CCO:B0005953 name: Q8NDD3_HUMAN def: "Putative uncharacterized protein DKFZp586M1819" [UniProtKB:Q8NDD3] xref: EMBL:CAD38930.1 xref: UniProtKB:Q8NDD3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006026 ! DKFZp586M1819_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007638 ! gfi1b-dkfzp586m1819 physical interaction [Term] id: CCO:B0005954 name: DTNA_HUMAN def: "Dystrobrevin alpha" [UniProtKB:Q9Y4J8] synonym: "Dystrobrevin-alpha" EXACT [UniProtKB:Q9Y4J8] synonym: "Dystrophin-related protein 3" EXACT [UniProtKB:Q9Y4J8] xref: EMBL:AAB58541.1 xref: EMBL:AAB58542.1 xref: EMBL:AAB58543.1 xref: EMBL:AAC50424.1 xref: EMBL:AAC50425.1 xref: EMBL:AAC50426.1 xref: EMBL:AAC50429.1 xref: EMBL:AAC50430.1 xref: EMBL:AAC50431.1 xref: EMBL:CAA08769.1 xref: UniProtKB:O15332 xref: UniProtKB:O15333 xref: UniProtKB:O75697 xref: UniProtKB:Q13197 xref: UniProtKB:Q13198 xref: UniProtKB:Q13199 xref: UniProtKB:Q13498 xref: UniProtKB:Q13499 xref: UniProtKB:Q13500 xref: UniProtKB:Q9Y4J8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004517 ! DTNA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007639 ! gfi1b-dtna physical interaction [Term] id: CCO:B0005955 name: FBLN3_HUMAN def: "EGF-containing fibulin-like extracellular matrix protein 1 precursor" [UniProtKB:Q12805] synonym: "Extracellular protein S1-5" EXACT [UniProtKB:Q12805] synonym: "FIBL-3" EXACT [UniProtKB:Q12805] synonym: "Fibrillin-like protein" EXACT [UniProtKB:Q12805] synonym: "Fibulin-3" EXACT [UniProtKB:Q12805] xref: EMBL:AAA65590.1 xref: EMBL:AAH14410.1 xref: EMBL:AAH98561.1 xref: EMBL:AAK11491.1 xref: UniProtKB:Q12805 xref: UniProtKB:Q541U7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004615 ! EFEMP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007640 ! gfi1b-efemp1 physical interaction relationship: participates_in CCO:I0007686 ! gfi1b-efemp1-1 physical interaction [Term] id: CCO:B0005956 name: MEGF6_HUMAN def: "Multiple epidermal growth factor-like domains 6 precursor" [UniProtKB:O75095] synonym: "EGF-like domain-containing protein 3" EXACT [UniProtKB:O75095] synonym: "Multiple EGF-like domain protein 3" EXACT [UniProtKB:O75095] xref: EMBL:BAA32467.2 xref: EMBL:CAH70834.1 xref: EMBL:CAI14334.1 xref: UniProtKB:O75095 xref: UniProtKB:Q5VV39 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005081 ! MEGF6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007642 ! gfi1b-megf6 physical interaction [Term] id: CCO:B0005957 name: MEGF8_HUMAN def: "Multiple epidermal growth factor-like domains 8" [UniProtKB:Q7Z7M0] synonym: "EGF-like domain-containing protein 4" EXACT [UniProtKB:Q7Z7M0] synonym: "Multiple EGF-like domain protein 4" EXACT [UniProtKB:Q7Z7M0] xref: EMBL:AAP35084.1 xref: EMBL:BAA32469.2 xref: UniProtKB:O75097 xref: UniProtKB:Q7Z7M0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005082 ! MEGF8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007643 ! gfi1b-megf8 physical interaction [Term] id: CCO:B0005958 name: EGFL7_HUMAN def: "EGF-like domain-containing protein 7 precursor" [UniProtKB:Q9UHF1] synonym: "Multiple EGF-like domain protein 7" EXACT [UniProtKB:Q9UHF1] synonym: "Multiple epidermal growth factor-like domain protein 7" EXACT [UniProtKB:Q9UHF1] synonym: "NOTCH4-like protein" EXACT [UniProtKB:Q9UHF1] synonym: "Vascular endothelial statin" EXACT [UniProtKB:Q9UHF1] synonym: "VE-statin" EXACT [UniProtKB:Q9UHF1] synonym: "ZNEU1" EXACT [UniProtKB:Q9UHF1] xref: EMBL:AAF01429.1 xref: EMBL:AAH12377.1 xref: EMBL:AAH88371.1 xref: EMBL:AAQ89260.1 xref: EMBL:AAQ89261.1 xref: EMBL:AAQ89262.1 xref: EMBL:BAD01469.1 xref: EMBL:CAC21666.1 xref: EMBL:CAH71721.1 xref: UniProtKB:Q5M7Y5 xref: UniProtKB:Q5VUD5 xref: UniProtKB:Q96EG0 xref: UniProtKB:Q9UHF1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004551 ! EGFL7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007644 ! gfi1b-egfl7 physical interaction [Term] id: CCO:B0005959 name: FBLN1_HUMAN def: "Fibulin-1 precursor" [UniProtKB:P23142] xref: EMBL:AAB17099.1 xref: EMBL:AAG17241.1 xref: EMBL:AAH22497.1 xref: EMBL:AAK37822.1 xref: EMBL:AAK82945.1 xref: EMBL:CAA37770.1 xref: EMBL:CAA37771.1 xref: EMBL:CAA37772.1 xref: EMBL:CAI18930.1 xref: EMBL:CAI19628.1 xref: EMBL:CAI41717.1 xref: UniProtKB:P23142 xref: UniProtKB:P23143 xref: UniProtKB:P23144 xref: UniProtKB:P37888 xref: UniProtKB:Q5TIC4 xref: UniProtKB:Q8TBH8 xref: UniProtKB:Q9HBQ5 xref: UniProtKB:Q9UC21 xref: UniProtKB:Q9UGR4 xref: UniProtKB:Q9UH41 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004614 ! FBLN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007645 ! gfi1b-fbln1 physical interaction [Term] id: CCO:B0005960 name: GRIP2_HUMAN def: "Glutamate receptor-interacting protein 2" [UniProtKB:Q9C0E4] synonym: "GRIP2 protein" EXACT [UniProtKB:Q9C0E4] xref: EMBL:BAB15797.1 xref: EMBL:BAB21810.2 xref: EMBL:BAB84971.1 xref: UniProtKB:Q8TEH9 xref: UniProtKB:Q9C0E4 xref: UniProtKB:Q9H7H3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004728 ! GRIP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007646 ! gfi1b-grip2 physical interaction [Term] id: CCO:B0005961 name: GRN_HUMAN def: "Granulins precursor" [UniProtKB:P28799] synonym: "PEPI" EXACT [UniProtKB:P28799] synonym: "Proepithelin" EXACT [UniProtKB:P28799] xref: EMBL:AAA58617.1 xref: EMBL:AAC09359.1 xref: EMBL:AAH00324.1 xref: EMBL:AAH10577.1 xref: EMBL:CAA44196.1 xref: UniProtKB:P23781 xref: UniProtKB:P23782 xref: UniProtKB:P23783 xref: UniProtKB:P23784 xref: UniProtKB:P28799 xref: UniProtKB:Q9BWE7 xref: UniProtKB:Q9UCH0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004730 ! GRN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007647 ! gfi1b-grn physical interaction [Term] id: CCO:B0005962 name: HECW1_HUMAN def: "E3 ubiquitin-protein ligase HECW1" [UniProtKB:Q76N89] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q76N89] synonym: "HECT, C2 and WW domain-containing protein 1" EXACT [UniProtKB:Q76N89] synonym: "hNEDL1" EXACT [UniProtKB:Q76N89] synonym: "NEDD4-like E3 ubiquitin-protein ligase 1" EXACT [UniProtKB:Q76N89] xref: EMBL:BAA20780.2 xref: EMBL:BAB13352.1 xref: UniProtKB:O15036 xref: UniProtKB:Q76N89 xref: UniProtKB:Q9HCC7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004798 ! HECW1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007648 ! gfi1b-hecw1 physical interaction [Term] id: CCO:B0005963 name: Q6P593_HUMAN def: "HOM-TES-103 protein" [UniProtKB:Q6P593] xref: EMBL:AAH63004.1 xref: UniProtKB:Q6P593 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006012 ! HOM-TES-103_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007651 ! gfi1b-hom_tes_103 physical interaction [Term] id: CCO:B0005964 name: PGBM_HUMAN def: "Basement membrane-specific heparan sulfate proteoglycan core protein precursor" [UniProtKB:P98160] synonym: "HSPG" EXACT [UniProtKB:P98160] synonym: "Perlecan" EXACT [UniProtKB:P98160] synonym: "PLC" EXACT [UniProtKB:P98160] xref: EMBL:AAA52699.1 xref: EMBL:AAA52700.1 xref: EMBL:AAB21121.2 xref: EMBL:CAA44373.1 xref: EMBL:CAC18534.1 xref: UniProtKB:P98160 xref: UniProtKB:Q16287 xref: UniProtKB:Q9H3V5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005303 ! HSPG2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007652 ! gfi1b-hspg2 physical interaction [Term] id: CCO:B0005965 name: ANKS3_HUMAN def: "Ankyrin repeat and SAM domain-containing protein 3" [UniProtKB:Q6ZW76] xref: EMBL:BAB85563.1 xref: EMBL:BAC85629.1 xref: UniProtKB:Q6ZW76 xref: UniProtKB:Q8TF25 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004060 ! ANKS3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007655 ! gfi1b-anks3 physical interaction relationship: transforms_into CCO:B0010529 ! ANKS3_HUMAN-Phosphoserine2 relationship: transforms_into CCO:B0010530 ! ANKS3_HUMAN-Phosphoserine5 relationship: transforms_into CCO:B0010531 ! ANKS3_HUMAN-Phosphoserine9 relationship: transforms_into CCO:B0010532 ! ANKS3_HUMAN-Phosphoserine320 [Term] id: CCO:B0005966 name: KIF17_HUMAN def: "Kinesin-like protein KIF17" [UniProtKB:Q9P2E2] synonym: "KIF3-related motor protein" EXACT [UniProtKB:Q9P2E2] xref: EMBL:AAD01428.1 xref: EMBL:AAH36871.1 xref: EMBL:AAH65927.1 xref: EMBL:AAR33039.1 xref: EMBL:BAA92643.2 xref: EMBL:CAH73471.1 xref: EMBL:CAI23390.1 xref: UniProtKB:O95077 xref: UniProtKB:Q53YS6 xref: UniProtKB:Q5VWA9 xref: UniProtKB:Q6GSA8 xref: UniProtKB:Q8N411 xref: UniProtKB:Q9P2E2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004942 ! KIF17_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007656 ! gfi1b-kif17 physical interaction [Term] id: CCO:B0005967 name: LAMB1_HUMAN def: "Laminin subunit beta-1 precursor" [UniProtKB:P07942] synonym: "Laminin B1 chain" EXACT [UniProtKB:P07942] xref: EMBL:AAA59482.1 xref: EMBL:AAA59485.1 xref: EMBL:AAA59486.1 xref: EMBL:AAA59487.1 xref: EMBL:AAI13456.1 xref: EMBL:EAL24388.1 xref: UniProtKB:P07942 xref: UniProtKB:Q14D91 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004969 ! LAMB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007657 ! gfi1b-lamb1 physical interaction [Term] id: CCO:B0005968 name: MATR3_HUMAN def: "Matrin-3" [UniProtKB:P43243] xref: EMBL:AAF17217.1 xref: EMBL:AAH15031.1 xref: EMBL:BAA34443.2 xref: UniProtKB:P43243 xref: UniProtKB:Q9UHW0 xref: UniProtKB:Q9UQ27 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005032 ! MATR3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007659 ! gfi1b-matr3 physical interaction relationship: transforms_into CCO:B0012782 ! MATR3_HUMAN-Phosphoserine188 relationship: transforms_into CCO:B0012783 ! MATR3_HUMAN-Phosphoserine195 relationship: transforms_into CCO:B0012784 ! MATR3_HUMAN-Phosphoserine208 relationship: transforms_into CCO:B0012785 ! MATR3_HUMAN-Phosphoserine397 relationship: transforms_into CCO:B0012786 ! MATR3_HUMAN-Phosphoserine596 relationship: transforms_into CCO:B0012787 ! MATR3_HUMAN-Phosphoserine598 relationship: transforms_into CCO:B0012788 ! MATR3_HUMAN-Phosphoserine604 relationship: transforms_into CCO:B0012789 ! MATR3_HUMAN-Phosphoserine654 relationship: transforms_into CCO:B0012790 ! MATR3_HUMAN-Phosphoserine671 relationship: transforms_into CCO:B0012791 ! MATR3_HUMAN-Phosphoserine673 relationship: transforms_into CCO:B0012792 ! MATR3_HUMAN-Phosphoserine674 relationship: transforms_into CCO:B0012793 ! MATR3_HUMAN-Phosphoserine696 [Term] id: CCO:B0005969 name: TRIM1_HUMAN def: "Midline-2" [UniProtKB:Q9UJV3] synonym: "Midin-2" EXACT [UniProtKB:Q9UJV3] synonym: "Midline defect 2" EXACT [UniProtKB:Q9UJV3] synonym: "RING finger protein 60" EXACT [UniProtKB:Q9UJV3] synonym: "Tripartite motif-containing protein 1" EXACT [UniProtKB:Q9UJV3] xref: EMBL:AAF07341.1 xref: EMBL:AAH17707.1 xref: EMBL:AAP35309.1 xref: EMBL:CAB56154.1 xref: EMBL:CAI42073.1 xref: EMBL:CAO72053.1 xref: UniProtKB:A6NEL8 xref: UniProtKB:A6PVI5 xref: UniProtKB:Q5JYF5 xref: UniProtKB:Q8WWK1 xref: UniProtKB:Q9UJR9 xref: UniProtKB:Q9UJV3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005834 ! MID2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007660 ! gfi1b-mid2 physical interaction [Term] id: CCO:B0005970 name: MON1A_HUMAN def: "Vacuolar fusion protein MON1 homolog A" [UniProtKB:Q86VX9] xref: EMBL:AAH06299.1 xref: EMBL:AAH09459.1 xref: EMBL:AAH47022.1 xref: EMBL:BAC03790.1 xref: UniProtKB:Q86VX9 xref: UniProtKB:Q8NAV7 xref: UniProtKB:Q9BRF3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005111 ! MON1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007661 ! gfi1b-mon1a physical interaction relationship: transforms_into CCO:B0012969 ! MON1A_HUMAN-Phosphoserine56 relationship: transforms_into CCO:B0012970 ! MON1A_HUMAN-Phosphotyrosine57 relationship: transforms_into CCO:B0012971 ! MON1A_HUMAN-Phosphoserine69 relationship: transforms_into CCO:B0012972 ! MON1A_HUMAN-Phosphoserine72 [Term] id: CCO:B0005971 name: MYH14_HUMAN def: "Myosin-14" [UniProtKB:Q7Z406] synonym: "Myosin heavy chain 14" EXACT [UniProtKB:Q7Z406] synonym: "Myosin heavy chain, non-muscle IIc" EXACT [UniProtKB:Q7Z406] synonym: "NMHC II-C" EXACT [UniProtKB:Q7Z406] synonym: "Non-muscle myosin heavy chain IIc" EXACT [UniProtKB:Q7Z406] xref: EMBL:AAH00676.2 xref: EMBL:AAH04396.1 xref: EMBL:AAH07877.2 xref: EMBL:AAH18933.2 xref: EMBL:AAO39147.1 xref: EMBL:AAP34449.1 xref: EMBL:BAB14735.1 xref: EMBL:BAC98374.1 xref: EMBL:CAI56791.1 xref: UniProtKB:Q5CZ75 xref: UniProtKB:Q6XYE4 xref: UniProtKB:Q76B62 xref: UniProtKB:Q7Z406 xref: UniProtKB:Q8WV23 xref: UniProtKB:Q96I22 xref: UniProtKB:Q9BT27 xref: UniProtKB:Q9BW35 xref: UniProtKB:Q9H882 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005143 ! MYH14_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007662 ! gfi1b-myh14 physical interaction relationship: transforms_into CCO:B0013066 ! MYH14_HUMAN-N-acetylalanine2 [Term] id: CCO:B0005972 name: NELF_HUMAN def: "Nasal embryonic luteinizing hormone-releasing hormone factor" [UniProtKB:Q6X4W1] synonym: "Nasal embryonic LHRH factor" EXACT [UniProtKB:Q6X4W1] xref: EMBL:AAH72412.1 xref: EMBL:AAP83576.1 xref: EMBL:AAP83577.1 xref: EMBL:AAP83578.1 xref: EMBL:AAP83579.1 xref: EMBL:AAP83580.1 xref: EMBL:BAB55139.1 xref: EMBL:BAC11086.1 xref: EMBL:CAB97524.1 xref: EMBL:CAB97525.1 xref: EMBL:CAB97542.1 xref: EMBL:CAI14577.1 xref: EMBL:CAI14578.1 xref: UniProtKB:Q6X4V7 xref: UniProtKB:Q6X4V8 xref: UniProtKB:Q6X4V9 xref: UniProtKB:Q6X4W1 xref: UniProtKB:Q8N2M2 xref: UniProtKB:Q96SY1 xref: UniProtKB:Q9NPM4 xref: UniProtKB:Q9NPP3 xref: UniProtKB:Q9NPS3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005180 ! NELF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007663 ! gfi1b-nelf physical interaction relationship: transforms_into CCO:B0013157 ! NELF_HUMAN-Phosphoserine288 [Term] id: CCO:B0005973 name: NELL1_HUMAN def: "Protein kinase C-binding protein NELL1 precursor" [UniProtKB:Q92832] synonym: "NEL-like protein 1" EXACT [UniProtKB:Q92832] synonym: "Nel-related protein 1" EXACT [UniProtKB:Q92832] xref: EMBL:AAB06946.1 xref: EMBL:AAH96101.1 xref: EMBL:BAA11680.1 xref: UniProtKB:Q4VB90 xref: UniProtKB:Q92832 xref: UniProtKB:Q9Y472 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005181 ! NELL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007664 ! gfi1b-nell1 physical interaction [Term] id: CCO:B0005974 name: NOTC1_HUMAN def: "Neurogenic locus notch homolog protein 1 precursor" [UniProtKB:P46531] synonym: "hN1" EXACT [UniProtKB:P46531] synonym: "Notch 1" EXACT [UniProtKB:P46531] synonym: "Translocation-associated notch protein TAN-1" EXACT [UniProtKB:P46531] xref: EMBL:AAA60614.1 xref: EMBL:AAG33848.1 xref: UniProtKB:P46531 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005208 ! NOTCH1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007666 ! gfi1b-notch1 physical interaction [Term] id: CCO:B0005975 name: Q5TB27_HUMAN def: "Phosphodiesterase 4D interacting protein" [UniProtKB:Q5TB27] synonym: "Myomegalin" EXACT [UniProtKB:Q5TB27] xref: EMBL:CAI22526.1 xref: UniProtKB:Q5TB27 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006001 ! PDE4DIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007667 ! gfi1b-pde4dip physical interaction [Term] id: CCO:B0005976 name: PDLI5_HUMAN def: "PDZ and LIM domain protein 5" [UniProtKB:Q96HC4] synonym: "Enigma homolog" EXACT [UniProtKB:Q96HC4] synonym: "Enigma-like PDZ and LIM domains protein" EXACT [UniProtKB:Q96HC4] xref: EMBL:AAC15767.1 xref: EMBL:AAH08741.1 xref: EMBL:AAP35992.1 xref: UniProtKB:O60705 xref: UniProtKB:Q96HC4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005292 ! PDLIM5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007668 ! gfi1b-enh physical interaction relationship: transforms_into CCO:B0013464 ! PDLI5_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0013465 ! PDLI5_HUMAN-Phosphothreonine110 relationship: transforms_into CCO:B0013466 ! PDLI5_HUMAN-Phosphoserine111 relationship: transforms_into CCO:B0013467 ! PDLI5_HUMAN-Phosphoserine134 relationship: transforms_into CCO:B0013468 ! PDLI5_HUMAN-Phosphoserine136 relationship: transforms_into CCO:B0013469 ! PDLI5_HUMAN-Phosphoserine137 relationship: transforms_into CCO:B0013470 ! PDLI5_HUMAN-Phosphoserine228 relationship: transforms_into CCO:B0013471 ! PDLI5_HUMAN-Phosphotyrosine251 relationship: transforms_into CCO:B0013472 ! PDLI5_HUMAN-Phosphoserine309 relationship: transforms_into CCO:B0013473 ! PDLI5_HUMAN-Phosphoserine313 relationship: transforms_into CCO:B0013474 ! PDLI5_HUMAN-Phosphoserine335 [Term] id: CCO:B0005977 name: PDZD4_HUMAN def: "PDZ domain-containing protein 4" [UniProtKB:Q76G19] synonym: "PDZ domain-containing RING finger protein 4-like protein" EXACT [UniProtKB:Q76G19] xref: EMBL:AAH02606.2 xref: EMBL:AAH80584.1 xref: EMBL:BAA95968.1 xref: EMBL:BAC03666.1 xref: EMBL:BAD16631.1 xref: UniProtKB:Q76G19 xref: UniProtKB:Q8NB75 xref: UniProtKB:Q9BUH9 xref: UniProtKB:Q9P284 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005296 ! PDZD4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007669 ! gfi1b-pdzk4 physical interaction [Term] id: CCO:B0005978 name: PHC2_HUMAN def: "Polyhomeotic-like protein 2" [UniProtKB:Q8IXK0] synonym: "Early development regulatory protein 2" EXACT [UniProtKB:Q8IXK0] synonym: "hPH2" EXACT [UniProtKB:Q8IXK0] xref: EMBL:AAH15450.1 xref: EMBL:AAH28396.3 xref: EMBL:AAH29269.1 xref: EMBL:AAH68573.1 xref: EMBL:AAH92492.1 xref: EMBL:AAI10864.2 xref: EMBL:AAI30631.1 xref: EMBL:BAC87622.1 xref: EMBL:CAB44779.1 xref: EMBL:CAD11673.1 xref: EMBL:CAI13955.1 xref: EMBL:CAI13956.1 xref: EMBL:CAI13957.1 xref: UniProtKB:A1L4Q1 xref: UniProtKB:Q2TAL3 xref: UniProtKB:Q5T0C1 xref: UniProtKB:Q6NUJ6 xref: UniProtKB:Q6ZQR1 xref: UniProtKB:Q8IXK0 xref: UniProtKB:Q8N306 xref: UniProtKB:Q8TAG8 xref: UniProtKB:Q96BL4 xref: UniProtKB:Q9Y4Y7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005308 ! PHC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007670 ! gfi1b-phc2 physical interaction relationship: transforms_into CCO:B0013502 ! PHC2_HUMAN-Phosphoserine701 relationship: transforms_into CCO:B0013503 ! PHC2_HUMAN-Phosphoserine704 relationship: transforms_into CCO:B0013504 ! PHC2_HUMAN-Phosphoserine733 relationship: transforms_into CCO:B0013505 ! PHC2_HUMAN-Phosphoserine745 [Term] id: CCO:B0005979 name: RFIP4_HUMAN def: "Rab11 family-interacting protein 4" [UniProtKB:Q86YS3] synonym: "Rab11-FIP4" EXACT [UniProtKB:Q86YS3] xref: EMBL:AAH93914.1 xref: EMBL:AAI01518.1 xref: EMBL:AAO21970.1 xref: EMBL:BAB47450.1 xref: EMBL:BAC05045.1 xref: EMBL:CAC44535.1 xref: EMBL:CAD38543.1 xref: UniProtKB:Q52LI1 xref: UniProtKB:Q86YS3 xref: UniProtKB:Q8N829 xref: UniProtKB:Q8NDT7 xref: UniProtKB:Q969D8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005474 ! RAB11FIP4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007672 ! gfi1b-rab11fip4 physical interaction [Term] id: CCO:B0005980 name: ZN363_HUMAN def: "RING finger and CHY zinc finger domain-containing protein 1" [UniProtKB:Q96PM5] synonym: "Androgen receptor N-terminal-interacting protein" EXACT [UniProtKB:Q96PM5] synonym: "CH-rich-interacting match with PLAG1" EXACT [UniProtKB:Q96PM5] synonym: "hPirh2" EXACT [UniProtKB:Q96PM5] synonym: "p53-induced RING-H2 protein" EXACT [UniProtKB:Q96PM5] synonym: "RING finger protein 199" EXACT [UniProtKB:Q96PM5] synonym: "Zinc finger protein 363" EXACT [UniProtKB:Q96PM5] xref: EMBL:AAK96896.1 xref: EMBL:AAL09356.1 xref: EMBL:AAL76101.1 xref: UniProtKB:Q96PM5 xref: UniProtKB:Q96PR5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005959 ! RCHY1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007673 ! gfi1b-rchy1 physical interaction relationship: transforms_into CCO:B0041222 ! ZN363_HUMAN-Phosphoserine257 [Term] id: CCO:B0005981 name: TRI27_HUMAN def: "Zinc finger protein RFP" [UniProtKB:P14373] synonym: "Ret finger protein" EXACT [UniProtKB:P14373] synonym: "RING finger protein 76" EXACT [UniProtKB:P14373] synonym: "Tripartite motif-containing protein 27" EXACT [UniProtKB:P14373] xref: EMBL:AAA36564.1 xref: EMBL:AAG50172.1 xref: EMBL:AAG50173.1 xref: EMBL:AAH13580.1 xref: EMBL:AAH66924.1 xref: EMBL:CAB06480.2 xref: EMBL:CAI17553.1 xref: EMBL:CAI18381.1 xref: EMBL:CAI18619.1 xref: EMBL:CAI18646.1 xref: EMBL:CAI19959.1 xref: UniProtKB:P14373 xref: UniProtKB:Q5ST26 xref: UniProtKB:Q6LA73 xref: UniProtKB:Q6NXR9 xref: UniProtKB:Q9BZY6 xref: UniProtKB:Q9UJL3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005828 ! TRIM27_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007674 ! gfi1b-rfp physical interaction [Term] id: CCO:B0005982 name: RNF31_HUMAN def: "RING finger protein 31" [UniProtKB:Q96EP0] synonym: "Zinc in-between-RING-finger ubiquitin-associated domain protein" EXACT [UniProtKB:Q96EP0] xref: EMBL:AAH09821.3 xref: EMBL:AAH12077.1 xref: EMBL:AAH17376.3 xref: EMBL:AAP12522.1 xref: EMBL:BAA91450.1 xref: EMBL:BAB15675.1 xref: EMBL:BAB70948.1 xref: EMBL:BAB84970.1 xref: UniProtKB:Q86VI2 xref: UniProtKB:Q8TEI0 xref: UniProtKB:Q96EP0 xref: UniProtKB:Q96GB4 xref: UniProtKB:Q96NF1 xref: UniProtKB:Q9H5F1 xref: UniProtKB:Q9NWD2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005520 ! RNF31_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007676 ! gfi1b-rnf31 physical interaction [Term] id: CCO:B0005984 name: TMF1_HUMAN def: "TATA element modulatory factor" [UniProtKB:P82094] synonym: "TMF" EXACT [UniProtKB:P82094] xref: EMBL:AAD54608.1 xref: UniProtKB:P82094 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005796 ! TMF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007679 ! gfi1b-tmf1 physical interaction relationship: transforms_into CCO:B0014418 ! TMF1_HUMAN-Phosphoserine72 relationship: transforms_into CCO:B0014419 ! TMF1_HUMAN-Phosphoserine77 [Term] id: CCO:B0005985 name: TRIP6_HUMAN def: "Thyroid receptor-interacting protein 6" [UniProtKB:Q15654] synonym: "OPA-interacting protein 1" EXACT [UniProtKB:Q15654] synonym: "TRIP-6" EXACT [UniProtKB:Q15654] synonym: "ZRP-1" EXACT [UniProtKB:Q15654] synonym: "Zyxin-related protein 1" EXACT [UniProtKB:Q15654] xref: EMBL:AAB62222.1 xref: EMBL:AAC41740.1 xref: EMBL:AAD03037.1 xref: EMBL:AAH02680.1 xref: EMBL:AAH04249.1 xref: EMBL:AAH04999.1 xref: EMBL:AAH21540.1 xref: EMBL:AAH28985.1 xref: EMBL:AAK21007.1 xref: EMBL:CAA05080.1 xref: UniProtKB:O15170 xref: UniProtKB:O15275 xref: UniProtKB:Q15654 xref: UniProtKB:Q9BTB2 xref: UniProtKB:Q9BUE5 xref: UniProtKB:Q9BXP3 xref: UniProtKB:Q9UNT4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005835 ! TRIP6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007680 ! gfi1b-trip6 physical interaction relationship: participates_in CCO:I0007693 ! gfi1b-trip6-1 physical interaction relationship: transforms_into CCO:B0014536 ! TRIP6_HUMAN-Phosphoserine92 [Term] id: CCO:B0005986 name: VISL1_HUMAN def: "Visinin-like protein 1" [UniProtKB:P62760] synonym: "Hippocalcin-like protein 3" EXACT [UniProtKB:P62760] synonym: "HLP3" EXACT [UniProtKB:P62760] synonym: "VILIP" EXACT [UniProtKB:P62760] xref: EMBL:AAA91295.1 xref: EMBL:AAD02174.1 xref: EMBL:AAH22012.1 xref: EMBL:BAA86891.1 xref: UniProtKB:P28677 xref: UniProtKB:P29103 xref: UniProtKB:P42323 xref: UniProtKB:P62760 xref: UniProtKB:Q9UM20 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005904 ! VSNL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007681 ! gfi1b-vsnl1 physical interaction [Term] id: CCO:B0005987 name: AES_HUMAN def: "Amino-terminal enhancer of split" [UniProtKB:Q08117] synonym: "Amino enhancer of split" EXACT [UniProtKB:Q08117] synonym: "Gp130-associated protein GAM" EXACT [UniProtKB:Q08117] synonym: "GRG protein" EXACT [UniProtKB:Q08117] synonym: "Protein ESP1" EXACT [UniProtKB:Q08117] xref: EMBL:AAA16223.1 xref: EMBL:AAC35517.1 xref: EMBL:AAC72103.1 xref: EMBL:AAD00654.1 xref: EMBL:CAA51768.1 xref: UniProtKB:Q08117 xref: UniProtKB:Q12808 xref: UniProtKB:Q96TG9 xref: UniProtKB:Q9UDY9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004033 ! AES_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007683 ! gfi1b-aes physical interaction [Term] id: CCO:B0005988 name: ATX2_HUMAN def: "Ataxin-2" [UniProtKB:Q99700] synonym: "Spinocerebellar ataxia type 2 protein" EXACT [UniProtKB:Q99700] synonym: "Trinucleotide repeat-containing gene 13 protein" EXACT [UniProtKB:Q99700] xref: EMBL:AAB19200.1 xref: EMBL:BAC87528.1 xref: EMBL:CAA69589.1 xref: UniProtKB:Q6ZQZ7 xref: UniProtKB:Q99493 xref: UniProtKB:Q99700 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004127 ! ATXN2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007684 ! gfi1b-atxn2 physical interaction relationship: transforms_into CCO:B0010710 ! ATX2_HUMAN-Phosphoserine643 relationship: transforms_into CCO:B0010711 ! ATX2_HUMAN-Phosphoserine683 relationship: transforms_into CCO:B0010712 ! ATX2_HUMAN-Phosphothreonine770 relationship: transforms_into CCO:B0010713 ! ATX2_HUMAN-Phosphoserine771 relationship: transforms_into CCO:B0010714 ! ATX2_HUMAN-Phosphoserine775 relationship: transforms_into CCO:B0010715 ! ATX2_HUMAN-Phosphoserine827 relationship: transforms_into CCO:B0010716 ! ATX2_HUMAN-Phosphoserine838 relationship: transforms_into CCO:B0010717 ! ATX2_HUMAN-Phosphoserine860 relationship: transforms_into CCO:B0010718 ! ATX2_HUMAN-Phosphoserine864 [Term] id: CCO:B0005989 name: FBLN5_HUMAN def: "Fibulin-5 precursor" [UniProtKB:Q9UBX5] synonym: "Dance" EXACT [UniProtKB:Q9UBX5] synonym: "Developmental arteries and neural crest EGF-like protein" EXACT [UniProtKB:Q9UBX5] synonym: "FIBL-5" EXACT [UniProtKB:Q9UBX5] synonym: "UP50" EXACT [UniProtKB:Q9UBX5] synonym: "Urine p50 protein" EXACT [UniProtKB:Q9UBX5] xref: EMBL:AAC62107.1 xref: EMBL:AAD41768.1 xref: EMBL:AAH22280.1 xref: EMBL:AAQ89257.1 xref: EMBL:CAB38568.1 xref: UniProtKB:O75966 xref: UniProtKB:Q6UWA3 xref: UniProtKB:Q9UBX5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004617 ! FBLN5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007688 ! gfi1b-fbln5 physical interaction [Term] id: CCO:B0005991 name: PSA3_HUMAN def: "Proteasome subunit alpha type-3" [UniProtKB:P25788] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P25788] synonym: "Macropain subunit C8" EXACT [UniProtKB:P25788] synonym: "Multicatalytic endopeptidase complex subunit C8" EXACT [UniProtKB:P25788] synonym: "Proteasome component C8" EXACT [UniProtKB:P25788] xref: EMBL:AAH05265.1 xref: EMBL:AAH29402.1 xref: EMBL:AAH38990.1 xref: EMBL:AAP35357.1 xref: EMBL:AAV38520.1 xref: EMBL:BAA00659.1 xref: UniProtKB:P25788 xref: UniProtKB:Q86U83 xref: UniProtKB:Q8N1D8 xref: UniProtKB:Q9BS70 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005386 ! PSMA3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007691 ! gfi1b-psma3 physical interaction relationship: participates_in CCO:I0008723 ! xrn2-psma3 physical interaction relationship: participates_in CCO:I0008730 ! alpha3-alpha4 physical interaction relationship: participates_in CCO:I0008731 ! alpha3-alpha2 physical interaction relationship: participates_in CCO:I0008732 ! alpha4-alpha3 physical interaction relationship: participates_in CCO:I0008753 ! beta5-alpha3 physical interaction relationship: participates_in CCO:I0008772 ! bat2-psma3 physical interaction relationship: participates_in CCO:I0008782 ! atn1-psma3 physical interaction relationship: participates_in CCO:I0008784 ! atn1-psma3-1 physical interaction relationship: participates_in CCO:I0008787 ! prnp-psma3 physical interaction relationship: participates_in CCO:I0008788 ! rere-psma3 physical interaction relationship: participates_in CCO:I0008789 ! rere-psma3-1 physical interaction relationship: participates_in CCO:I0008792 ! psma3-psma6-1 physical interaction relationship: participates_in CCO:I0008795 ! psma6-psma3 physical interaction relationship: participates_in CCO:I0008797 ! snrpf-psma3 physical interaction relationship: participates_in CCO:I0008802 ! snrpb-psma3 physical interaction relationship: participates_in CCO:I0008803 ! stx11-psma3 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0013619 ! PSA3_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0013620 ! PSA3_HUMAN-Phosphotyrosine161 relationship: transforms_into CCO:B0013621 ! PSA3_HUMAN-Phosphoserine243 relationship: transforms_into CCO:B0013622 ! PSA3_HUMAN-Phosphoserine250 [Term] id: CCO:B0005992 name: TRAF1_HUMAN def: "TNF receptor-associated factor 1" [UniProtKB:Q13077] synonym: "Epstein-Barr virus-induced protein 6" EXACT [UniProtKB:Q13077] xref: EMBL:AAA62309.1 xref: EMBL:AAH24145.1 xref: EMBL:AAV38215.1 xref: EMBL:BAC03449.1 xref: UniProtKB:Q13077 xref: UniProtKB:Q8NF13 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005822 ! TRAF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007692 ! gfi1b-traf1 physical interaction [Term] id: CCO:B0005993 name: TXD11_HUMAN def: "Thioredoxin domain-containing protein 11" [UniProtKB:Q6PKC3] synonym: "EF-hand-binding protein 1" EXACT [UniProtKB:Q6PKC3] xref: EMBL:AAD20043.1 xref: EMBL:AAH02856.1 xref: EMBL:AAH13727.1 xref: EMBL:AAH18635.1 xref: EMBL:BAB55129.1 xref: EMBL:BAB55262.1 xref: EMBL:BAC11044.1 xref: EMBL:CAG33433.1 xref: UniProtKB:O95887 xref: UniProtKB:Q6PJA6 xref: UniProtKB:Q6PKC3 xref: UniProtKB:Q8N2Q4 xref: UniProtKB:Q96K45 xref: UniProtKB:Q96K53 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005846 ! TXNDC11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007694 ! gfi1b-txndc11 physical interaction relationship: transforms_into CCO:B0041221 ! TXD11_HUMAN-Phosphoserine828 [Term] id: CCO:B0005996 name: WDR57_HUMAN def: "WD repeat-containing protein 57" [UniProtKB:Q96DI7] synonym: "38 kDa-splicing factor" EXACT [UniProtKB:Q96DI7] synonym: "hPRP8BP" EXACT [UniProtKB:Q96DI7] synonym: "Prp8-binding protein" EXACT [UniProtKB:Q96DI7] synonym: "U5 snRNP-specific 40 kDa protein" EXACT [UniProtKB:Q96DI7] xref: EMBL:AAC64084.1 xref: EMBL:AAC69625.1 xref: EMBL:AAH01494.1 xref: EMBL:CAH71848.1 xref: UniProtKB:O75938 xref: UniProtKB:O95320 xref: UniProtKB:Q96DI7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005921 ! WDR57_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: participates_in CCO:I0008531 ! wdr57-ddb1 physical interaction [Term] id: CCO:B0005997 name: WDR76_HUMAN def: "WD repeat-containing protein 76" [UniProtKB:Q9H967] xref: EMBL:AAH51855.1 xref: EMBL:BAB14369.1 xref: UniProtKB:Q9H967 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005927 ! WDR76_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction [Term] id: CCO:B0005998 name: WD51B_HUMAN def: "WD repeat-containing protein 51B" [UniProtKB:Q8TC44] xref: EMBL:AAH26080.1 xref: EMBL:BAC11198.1 xref: UniProtKB:Q8TC44 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005916 ! WDR51B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction [Term] id: CCO:B0005999 name: WDR61_HUMAN def: "WD repeat-containing protein 61" [UniProtKB:Q9GZS3] synonym: "Meiotic recombination REC14 protein homolog" EXACT [UniProtKB:Q9GZS3] xref: EMBL:AAG31639.1 xref: EMBL:AAH10080.1 xref: EMBL:AAP97225.1 xref: EMBL:AAP97249.1 xref: EMBL:BAB14986.1 xref: EMBL:CAG33614.1 xref: UniProtKB:Q6IA22 xref: UniProtKB:Q7Z4X4 xref: UniProtKB:Q9GZS3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005924 ! WDR61_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: transforms_into CCO:B0014676 ! WDR61_HUMAN-N-acetylthreonine2 [Term] id: CCO:B0006000 name: WDR5B_HUMAN def: "WD repeat-containing protein 5B" [UniProtKB:Q86VZ2] xref: EMBL:AAH43494.1 xref: EMBL:BAA92110.1 xref: EMBL:CAG33560.1 xref: UniProtKB:Q86VZ2 xref: UniProtKB:Q9NUL4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005922 ! WDR5B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: participates_in CCO:I0008533 ! wdr5b-ddb1 physical interaction [Term] id: CCO:B0006001 name: RFWD2_HUMAN def: "E3 ubiquitin-protein ligase RFWD2" [UniProtKB:Q8NHY2] synonym: "Constitutive photomorphogenesis protein 1 homolog" EXACT [UniProtKB:Q8NHY2] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q8NHY2] synonym: "hCOP1" EXACT [UniProtKB:Q8NHY2] synonym: "RING finger and WD repeat domain protein 2" EXACT [UniProtKB:Q8NHY2] synonym: "RING finger protein 200" EXACT [UniProtKB:Q8NHY2] xref: EMBL:AAM34692.1 xref: EMBL:AAS82851.1 xref: EMBL:BAB15239.1 xref: EMBL:DAA01050.1 xref: UniProtKB:Q6H103 xref: UniProtKB:Q8NHY2 xref: UniProtKB:Q9H6L7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005475 ! RFWD2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007716 ! cul4b-ddb1-1 physical interaction relationship: participates_in CCO:I0008529 ! cop1-ddb1 physical interaction [Term] id: CCO:B0006004 name: CSMD1_HUMAN def: "CUB and sushi domain-containing protein 1 precursor" [UniProtKB:Q96PZ7] synonym: "CUB and sushi multiple domains protein 1" EXACT [UniProtKB:Q96PZ7] xref: EMBL:AAG52948.1 xref: EMBL:AAK73475.2 xref: EMBL:AAQ88541.1 xref: EMBL:BAB67783.1 xref: EMBL:BAC86754.1 xref: UniProtKB:Q96PZ7 xref: UniProtKB:Q96QU9 xref: UniProtKB:Q96RM4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004406 ! CSMD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006005 name: LSM1_HUMAN def: "U6 snRNA-associated Sm-like protein LSm1" [UniProtKB:O15116] synonym: "Cancer-associated Sm-like" EXACT [UniProtKB:O15116] synonym: "Small nuclear ribonuclear CaSm" EXACT [UniProtKB:O15116] xref: EMBL:AAB62189.1 xref: EMBL:AAH01767.1 xref: EMBL:CAB45865.1 xref: UniProtKB:O15116 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004991 ! LSM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: participates_in CCO:I0008721 ! lsm1-psmb8 physical interaction relationship: participates_in CCO:I0008722 ! lsm1-psmb5 physical interaction [Term] id: CCO:B0006006 name: EHMT1_HUMAN def: "Histone-lysine N-methyltransferase, H3 lysine-9 specific 5" [UniProtKB:Q9H9B1] synonym: "EC 2.1.1.43" EXACT [UniProtKB:Q9H9B1] synonym: "Eu-HMTase1" EXACT [UniProtKB:Q9H9B1] synonym: "Euchromatic histone-lysine N-methyltransferase 1" EXACT [UniProtKB:Q9H9B1] synonym: "G9a-like protein 1" EXACT [UniProtKB:Q9H9B1] synonym: "GLP1" EXACT [UniProtKB:Q9H9B1] synonym: "H3-K9-HMTase 5" EXACT [UniProtKB:Q9H9B1] synonym: "Histone H3-K9 methyltransferase 5" EXACT [UniProtKB:Q9H9B1] synonym: "Lysine N-methyltransferase 1D" EXACT [UniProtKB:Q9H9B1] xref: EMBL:AAH11608.2 xref: EMBL:AAM09024.1 xref: EMBL:BAB14321.1 xref: EMBL:BAB47505.2 xref: EMBL:BAB56104.1 xref: EMBL:CAD28534.1 xref: UniProtKB:Q8TCN7 xref: UniProtKB:Q96F53 xref: UniProtKB:Q96JF1 xref: UniProtKB:Q96KH4 xref: UniProtKB:Q9H9B1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004555 ! EHMT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0011669 ! EHMT1_HUMAN-Phosphoserine466 [Term] id: CCO:B0006007 name: ARI1A_HUMAN def: "AT-rich interactive domain-containing protein 1A" [UniProtKB:O14497] synonym: "ARID domain-containing protein 1A" EXACT [UniProtKB:O14497] synonym: "B120" EXACT [UniProtKB:O14497] synonym: "BAF250" EXACT [UniProtKB:O14497] synonym: "BAF250A" EXACT [UniProtKB:O14497] synonym: "BRG1-associated factor 250" EXACT [UniProtKB:O14497] synonym: "BRG1-associated factor 250a" EXACT [UniProtKB:O14497] synonym: "hELD" EXACT [UniProtKB:O14497] synonym: "hOSA1" EXACT [UniProtKB:O14497] synonym: "Osa homolog 1" EXACT [UniProtKB:O14497] synonym: "SWI-like protein" EXACT [UniProtKB:O14497] synonym: "SWI-SNF complex protein p270" EXACT [UniProtKB:O14497] synonym: "SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1" EXACT [UniProtKB:O14497] xref: EMBL:AAF75765.1 xref: EMBL:AAG17549.2 xref: EMBL:AAG33967.1 xref: EMBL:AAK54505.1 xref: EMBL:AAN03446.1 xref: EMBL:BAA23269.1 xref: EMBL:BAA83073.1 xref: EMBL:BAD96995.1 xref: EMBL:CAI21621.1 xref: EMBL:CAI21622.1 xref: EMBL:CAI21623.1 xref: EMBL:CAI23482.1 xref: EMBL:CAI23483.1 xref: EMBL:CAI23484.1 xref: UniProtKB:O14497 xref: UniProtKB:Q53FK9 xref: UniProtKB:Q5T0W1 xref: UniProtKB:Q5T0W2 xref: UniProtKB:Q5T0W3 xref: UniProtKB:Q8NFD6 xref: UniProtKB:Q96T89 xref: UniProtKB:Q9BY33 xref: UniProtKB:Q9HBJ5 xref: UniProtKB:Q9UPZ1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004091 ! ARID1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0010596 ! ARI1A_HUMAN-Phosphoserine363 relationship: transforms_into CCO:B0010597 ! ARI1A_HUMAN-Phosphoserine604 relationship: transforms_into CCO:B0010598 ! ARI1A_HUMAN-Phosphoserine696 relationship: transforms_into CCO:B0010599 ! ARI1A_HUMAN-Phosphoserine772 relationship: transforms_into CCO:B0010600 ! ARI1A_HUMAN-Phosphoserine1755 [Term] id: CCO:B0006008 name: HNF1A_HUMAN def: "Hepatocyte nuclear factor 1-alpha" [UniProtKB:P20823] synonym: "HNF-1A" EXACT [UniProtKB:P20823] synonym: "LFB1" EXACT [UniProtKB:P20823] synonym: "Liver-specific transcription factor LF-B1" EXACT [UniProtKB:P20823] synonym: "TCF-1" EXACT [UniProtKB:P20823] synonym: "Transcription factor 1" EXACT [UniProtKB:P20823] xref: EMBL:AAA88077.1 xref: EMBL:AAC51137.1 xref: EMBL:AAI04909.1 xref: EMBL:AAI04911.1 xref: EMBL:CAB59201.1 xref: UniProtKB:P20823 xref: UniProtKB:Q2M3H2 xref: UniProtKB:Q99861 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006359 ! HNF1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0012199 ! HNF1A_HUMAN-Phosphothreonine74 [Term] id: CCO:B0006009 name: OSBL1_HUMAN def: "Oxysterol-binding protein-related protein 1" [UniProtKB:Q9BXW6] synonym: "ORP-1" EXACT [UniProtKB:Q9BXW6] synonym: "OSBP-related protein 1" EXACT [UniProtKB:Q9BXW6] xref: EMBL:AAG53407.2 xref: EMBL:AAK15154.1 xref: EMBL:AAL40662.1 xref: EMBL:AAL40663.1 xref: EMBL:BAA91496.1 xref: UniProtKB:Q9BXW6 xref: UniProtKB:Q9BZF5 xref: UniProtKB:Q9NW87 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005238 ! OSBPL1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0013338 ! OSBL1_HUMAN-Phosphoserine499 [Term] id: CCO:B0006010 name: TNR8_HUMAN def: "Tumor necrosis factor receptor superfamily member 8 precursor" [UniProtKB:P28908] synonym: "CD30L receptor" EXACT [UniProtKB:P28908] synonym: "KI-1 antigen" EXACT [UniProtKB:P28908] synonym: "Lymphocyte activation antigen CD30" EXACT [UniProtKB:P28908] xref: EMBL:AAA51947.1 xref: EMBL:AAD14188.1 xref: EMBL:AAR32099.1 xref: EMBL:BAA12973.1 xref: EMBL:CAC16652.1 xref: UniProtKB:P28908 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005806 ! TNFRSF8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006011 name: TYY1_HUMAN def: "Transcriptional repressor protein YY1" [UniProtKB:P25490] synonym: "Delta transcription factor" EXACT [UniProtKB:P25490] synonym: "NF-E1" EXACT [UniProtKB:P25490] synonym: "Yin and yang 1" EXACT [UniProtKB:P25490] synonym: "YY-1" EXACT [UniProtKB:P25490] xref: EMBL:AAA59467.1 xref: EMBL:AAA59926.1 xref: EMBL:AAH37308.1 xref: EMBL:AAH65366.1 xref: EMBL:CAA78455.1 xref: UniProtKB:P25490 xref: UniProtKB:Q14935 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005851 ! YY1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0014559 ! TYY1_HUMAN-Phosphoserine118 relationship: transforms_into CCO:B0014560 ! TYY1_HUMAN-Phosphoserine184 relationship: transforms_into CCO:B0014561 ! TYY1_HUMAN-Phosphoserine247 relationship: transforms_into CCO:B0014562 ! TYY1_HUMAN-Phosphothreonine348 [Term] id: CCO:B0006012 name: 4ET_HUMAN def: "Eukaryotic translation initiation factor 4E transporter" [UniProtKB:Q9NRA8] synonym: "4E-T" EXACT [UniProtKB:Q9NRA8] synonym: "eIF4E transporter" EXACT [UniProtKB:Q9NRA8] synonym: "Eukaryotic translation initiation factor 4E nuclear import factor 1" EXACT [UniProtKB:Q9NRA8] xref: EMBL:AAF81693.1 xref: EMBL:AAH32941.1 xref: EMBL:AAH33028.1 xref: EMBL:BAB15092.1 xref: EMBL:BAC11194.1 xref: EMBL:CAG30272.1 xref: UniProtKB:Q8NCF2 xref: UniProtKB:Q9H708 xref: UniProtKB:Q9NRA8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004004 ! EIF4ENIF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0010378 ! 4ET_HUMAN-Phosphoserine78 relationship: transforms_into CCO:B0010379 ! 4ET_HUMAN-Phosphoserine587 relationship: transforms_into CCO:B0041107 ! 4ET_HUMAN-Phosphoserine914 relationship: transforms_into CCO:B0041108 ! 4ET_HUMAN-Phosphoserine920 [Term] id: CCO:B0006013 name: DDX6_HUMAN def: "Probable ATP-dependent RNA helicase DDX6" [UniProtKB:P26196] synonym: "ATP-dependent RNA helicase p54" EXACT [UniProtKB:P26196] synonym: "DEAD box protein 6" EXACT [UniProtKB:P26196] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P26196] synonym: "Oncogene RCK" EXACT [UniProtKB:P26196] xref: EMBL:AAH65007.1 xref: EMBL:BAA04482.1 xref: UniProtKB:P26196 xref: UniProtKB:Q5D048 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004460 ! DDX6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0011486 ! DDX6_HUMAN-Phosphothreonine36 [Term] id: CCO:B0006014 name: ZN443_HUMAN def: "Zinc finger protein 443" [UniProtKB:Q9Y2A4] synonym: "Krueppel-type zinc finger protein ZK1" EXACT [UniProtKB:Q9Y2A4] xref: EMBL:AAH32753.1 xref: EMBL:BAA75543.1 xref: UniProtKB:Q9Y2A4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005960 ! ZNF443_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006015 name: E2AK3_HUMAN def: "Eukaryotic translation initiation factor 2-alpha kinase 3 precursor" [UniProtKB:Q9NZJ5] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q9NZJ5] synonym: "HsPEK" EXACT [UniProtKB:Q9NZJ5] synonym: "Pancreatic eIF2-alpha kinase" EXACT [UniProtKB:Q9NZJ5] synonym: "PRKR-like endoplasmic reticulum kinase" EXACT [UniProtKB:Q9NZJ5] xref: EMBL:AAD19961.1 xref: EMBL:AAF61199.1 xref: EMBL:AAF91480.1 xref: EMBL:AAI26357.1 xref: UniProtKB:A0AVH2 xref: UniProtKB:O95846 xref: UniProtKB:Q9NZJ5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004532 ! EIF2AK3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006016 name: ATF7_HUMAN def: "Cyclic AMP-dependent transcription factor ATF-7" [UniProtKB:P17544] synonym: "Activating transcription factor 7" EXACT [UniProtKB:P17544] synonym: "Transcription factor ATF-A" EXACT [UniProtKB:P17544] xref: EMBL:CAA37118.1 xref: EMBL:CAA40483.1 xref: UniProtKB:P17544 xref: UniProtKB:Q13814 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004116 ! ATF7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0010643 ! ATF7_HUMAN-Phosphothreonine51 relationship: transforms_into CCO:B0010644 ! ATF7_HUMAN-Phosphothreonine53 relationship: transforms_into CCO:B0010645 ! ATF7_HUMAN-Phosphoserine111 relationship: transforms_into CCO:B0010646 ! ATF7_HUMAN-Phosphothreonine112 relationship: transforms_into CCO:B0010647 ! ATF7_HUMAN-Phosphoserine127 relationship: transforms_into CCO:B0010648 ! ATF7_HUMAN-Phosphoserine128 relationship: transforms_into CCO:B0010649 ! ATF7_HUMAN-Phosphoserine132 relationship: transforms_into CCO:B0010650 ! ATF7_HUMAN-Phosphoserine135 relationship: transforms_into CCO:B0010651 ! ATF7_HUMAN-Phosphoserine136 relationship: transforms_into CCO:B0010652 ! ATF7_HUMAN-Phosphoserine139 [Term] id: CCO:B0006017 name: SPTC2_HUMAN def: "Serine palmitoyltransferase 2" [UniProtKB:O15270] synonym: "EC 2.3.1.50" EXACT [UniProtKB:O15270] synonym: "LCB 2" EXACT [UniProtKB:O15270] synonym: "Long chain base biosynthesis protein 2" EXACT [UniProtKB:O15270] synonym: "Serine-palmitoyl-CoA transferase 2" EXACT [UniProtKB:O15270] synonym: "SPT 2" EXACT [UniProtKB:O15270] xref: EMBL:AAC50871.1 xref: EMBL:AAD09621.1 xref: EMBL:AAH05123.1 xref: EMBL:BAA25452.2 xref: EMBL:CAA69942.1 xref: UniProtKB:O15270 xref: UniProtKB:Q16685 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005668 ! SPTLC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0014199 ! SPTC2_HUMAN-Phosphoserine384 relationship: transforms_into CCO:B0014200 ! SPTC2_HUMAN-Phosphotyrosine387 [Term] id: CCO:B0006018 name: SENP7_HUMAN def: "Sentrin-specific protease 7" [UniProtKB:Q9BQF6] synonym: "EC 3.4.22.-" EXACT [UniProtKB:Q9BQF6] synonym: "Sentrin/SUMO-specific protease SENP7" EXACT [UniProtKB:Q9BQF6] synonym: "SUMO-1-specific protease 2" EXACT [UniProtKB:Q9BQF6] xref: EMBL:AAG09703.1 xref: EMBL:AAL25651.1 xref: EMBL:BAB21798.1 xref: EMBL:CAB66534.1 xref: EMBL:CAD97911.1 xref: UniProtKB:Q7Z3F4 xref: UniProtKB:Q96PS5 xref: UniProtKB:Q9BQF6 xref: UniProtKB:Q9C0F6 xref: UniProtKB:Q9HBT5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005580 ! SENP7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0013988 ! SENP7_HUMAN-Phosphoserine377 relationship: transforms_into CCO:B0013989 ! SENP7_HUMAN-Phosphoserine378 [Term] id: CCO:B0006019 name: LPP3_HUMAN def: "Lipid phosphate phosphohydrolase 3" [UniProtKB:O14495] synonym: "EC 3.1.3.4" EXACT [UniProtKB:O14495] synonym: "PAP-2b" EXACT [UniProtKB:O14495] synonym: "PAP2-beta" EXACT [UniProtKB:O14495] synonym: "PAP2b" EXACT [UniProtKB:O14495] synonym: "Phosphatidate phosphohydrolase type 2b" EXACT [UniProtKB:O14495] synonym: "Phosphatidic acid phosphatase 2b" EXACT [UniProtKB:O14495] synonym: "Vascular endothelial growth factor and type I collagen-inducible protein" EXACT [UniProtKB:O14495] synonym: "VCIP" EXACT [UniProtKB:O14495] xref: EMBL:AAB50222.1 xref: EMBL:AAC63433.1 xref: EMBL:AAD02271.1 xref: EMBL:AAH09196.1 xref: EMBL:AAO84481.1 xref: EMBL:BAA22594.1 xref: UniProtKB:O14495 xref: UniProtKB:Q96GW0 xref: UniProtKB:Q99782 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004986 ! PPAP2B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0012705 ! LPP3_HUMAN-Phosphotyrosine110 [Term] id: CCO:B0006020 name: BC11A_HUMAN def: "B-cell lymphoma/leukemia 11A" [UniProtKB:Q9H165] synonym: "B-cell CLL/lymphoma 11A" EXACT [UniProtKB:Q9H165] synonym: "COUP-TF-interacting protein 1" EXACT [UniProtKB:Q9H165] synonym: "Ecotropic viral integration site 9 protein homolog" EXACT [UniProtKB:Q9H165] synonym: "EVI-9" EXACT [UniProtKB:Q9H165] xref: EMBL:AAG49025.1 xref: EMBL:AAH21098.1 xref: EMBL:AAO88272.1 xref: EMBL:BAA91476.1 xref: EMBL:BAB47438.1 xref: EMBL:CAC17723.1 xref: EMBL:CAC17724.1 xref: EMBL:CAC17725.1 xref: UniProtKB:Q86W14 xref: UniProtKB:Q8WU92 xref: UniProtKB:Q96JL6 xref: UniProtKB:Q9H163 xref: UniProtKB:Q9H164 xref: UniProtKB:Q9H165 xref: UniProtKB:Q9H3G9 xref: UniProtKB:Q9NWA7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004145 ! BCL11A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006021 name: IDI2_HUMAN def: "Isopentenyl-diphosphate Delta-isomerase 2" [UniProtKB:Q9BXS1] synonym: "EC 5.3.3.2" EXACT [UniProtKB:Q9BXS1] synonym: "IPP isomerase 2" EXACT [UniProtKB:Q9BXS1] synonym: "IPPI2" EXACT [UniProtKB:Q9BXS1] synonym: "Isopentenyl pyrophosphate isomerase 2" EXACT [UniProtKB:Q9BXS1] xref: EMBL:AAH17778.1 xref: EMBL:AAK29358.1 xref: EMBL:AAK49436.1 xref: EMBL:AAK49437.1 xref: EMBL:BAB71322.1 xref: UniProtKB:Q9BXS1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004850 ! IDI2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006022 name: PCDH9_HUMAN def: "Protocadherin-9 precursor" [UniProtKB:Q9HC56] xref: EMBL:AAF89689.2 xref: EMBL:CAH72612.1 xref: EMBL:CAH72759.1 xref: EMBL:CAI12502.1 xref: UniProtKB:Q5VT83 xref: UniProtKB:Q9HC56 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005276 ! PCDH9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006023 name: T3JAM_HUMAN def: "TRAF3-interacting JNK-activating modulator" [UniProtKB:Q9Y228] synonym: "TRAF3-interacting protein 3" EXACT [UniProtKB:Q9Y228] xref: EMBL:AAI10303.1 xref: EMBL:CAB41242.1 xref: EMBL:CAI95687.1 xref: UniProtKB:Q2YDB5 xref: UniProtKB:Q4VY06 xref: UniProtKB:Q7Z706 xref: UniProtKB:Q9Y228 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005717 ! TRAF3IP3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006024 name: EPHB6_HUMAN def: "Ephrin type-B receptor 6 precursor" [UniProtKB:O15197] synonym: "HEP" EXACT [UniProtKB:O15197] synonym: "Tyrosine-protein kinase-defective receptor EPH-6" EXACT [UniProtKB:O15197] xref: EMBL:AAD03058.1 xref: EMBL:AAP20939.1 xref: EMBL:BAA21560.1 xref: UniProtKB:O15197 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004576 ! EPHB6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006025 name: WDR35_HUMAN def: "WD repeat-containing protein 35" [UniProtKB:Q9P2L0] xref: EMBL:AAH36659.1 xref: EMBL:BAA92574.2 xref: UniProtKB:Q8NE11 xref: UniProtKB:Q9P2L0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005919 ! WDR35_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006026 name: RNC_HUMAN def: "Ribonuclease 3" [UniProtKB:Q9NRR4] synonym: "Drosha" EXACT [UniProtKB:Q9NRR4] synonym: "EC 3.1.26.3" EXACT [UniProtKB:Q9NRR4] synonym: "p241" EXACT [UniProtKB:Q9NRR4] synonym: "Ribonuclease III" EXACT [UniProtKB:Q9NRR4] synonym: "RNase III" EXACT [UniProtKB:Q9NRR4] xref: EMBL:AAD29637.1 xref: EMBL:AAF80558.1 xref: EMBL:AAH41162.1 xref: EMBL:AAH54003.1 xref: EMBL:BAA91511.1 xref: EMBL:CAB45133.1 xref: UniProtKB:Q7Z5V2 xref: UniProtKB:Q86YH0 xref: UniProtKB:Q9NRR4 xref: UniProtKB:Q9NW73 xref: UniProtKB:Q9Y2V9 xref: UniProtKB:Q9Y4Y0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005518 ! RNASEN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0013908 ! RNC_HUMAN-Phosphoserine284 [Term] id: CCO:B0006027 name: ELF1_HUMAN def: "ETS-related transcription factor Elf-1" [UniProtKB:P32519] synonym: "E74-like factor 1" EXACT [UniProtKB:P32519] xref: UniProtKB:P32519 xref: UniProtKB:Q9UDE1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004558 ! ELF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0011670 ! ELF1_HUMAN-Phosphoserine168 relationship: transforms_into CCO:B0011671 ! ELF1_HUMAN-Phosphoserine432 relationship: transforms_into CCO:B0011672 ! ELF1_HUMAN-Phosphoserine474 relationship: transforms_into CCO:B0011673 ! ELF1_HUMAN-Phosphothreonine566 [Term] id: CCO:B0006028 name: DYH9_HUMAN def: "Dynein heavy chain 9, axonemal" [UniProtKB:Q9NYC9] synonym: "Axonemal beta dynein heavy chain 9" EXACT [UniProtKB:Q9NYC9] synonym: "Ciliary dynein heavy chain 9" EXACT [UniProtKB:Q9NYC9] xref: EMBL:AAF69004.1 xref: EMBL:CAA10561.1 xref: EMBL:CAB94756.1 xref: UniProtKB:O95494 xref: UniProtKB:Q9NQ28 xref: UniProtKB:Q9NYC9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004525 ! DNAH9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006029 name: PANX3_HUMAN def: "Pannexin-3" [UniProtKB:Q96QZ0] xref: EMBL:AAK95655.1 xref: UniProtKB:Q96QZ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005257 ! PANX3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006030 name: COE1_HUMAN def: "Transcription factor COE1" [UniProtKB:Q9UH73] synonym: "Early B-cell factor" EXACT [UniProtKB:Q9UH73] synonym: "O/E-1" EXACT [UniProtKB:Q9UH73] synonym: "OE-1" EXACT [UniProtKB:Q9UH73] xref: EMBL:AAF19643.1 xref: EMBL:AAH38805.1 xref: EMBL:AAH41178.1 xref: UniProtKB:Q8IW11 xref: UniProtKB:Q9UH73 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004384 ! EBF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006031 name: PRGC1_HUMAN def: "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha" [UniProtKB:Q9UBK2] synonym: "Ligand effect modulator 6" EXACT [UniProtKB:Q9UBK2] synonym: "PGC-1-alpha" EXACT [UniProtKB:Q9UBK2] synonym: "PPAR-gamma coactivator 1-alpha" EXACT [UniProtKB:Q9UBK2] synonym: "PPARGC-1-alpha" EXACT [UniProtKB:Q9UBK2] xref: EMBL:AAD51615.1 xref: EMBL:AAD56250.1 xref: EMBL:AAF18573.1 xref: EMBL:AAF19083.1 xref: UniProtKB:Q9UBK2 xref: UniProtKB:Q9UN32 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005374 ! PPARGC1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006032 name: WBP7_HUMAN def: "WW domain-binding protein 7" [UniProtKB:Q9UMN6] synonym: "Lysine N-methyltransferase 2D" EXACT [UniProtKB:Q9UMN6] synonym: "Myeloid/lymphoid or mixed-lineage leukemia protein 4" EXACT [UniProtKB:Q9UMN6] synonym: "Trithorax homolog 2" EXACT [UniProtKB:Q9UMN6] synonym: "WBP-7" EXACT [UniProtKB:Q9UMN6] xref: EMBL:AAD17932.1 xref: EMBL:AAD26112.1 xref: EMBL:AAD26113.1 xref: EMBL:AAD56420.1 xref: EMBL:AAH07353.2 xref: EMBL:AAH09337.2 xref: EMBL:BAA20763.3 xref: EMBL:CAB45385.1 xref: UniProtKB:O15022 xref: UniProtKB:O95836 xref: UniProtKB:Q96GP2 xref: UniProtKB:Q96IP3 xref: UniProtKB:Q9UK25 xref: UniProtKB:Q9UMN6 xref: UniProtKB:Q9Y668 xref: UniProtKB:Q9Y669 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005915 ! WBP7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0014669 ! WBP7_HUMAN-Phosphothreonine159 relationship: transforms_into CCO:B0014670 ! WBP7_HUMAN-Phosphoserine320 relationship: transforms_into CCO:B0014671 ! WBP7_HUMAN-Phosphoserine861 relationship: transforms_into CCO:B0014672 ! WBP7_HUMAN-Phosphoserine1164 [Term] id: CCO:B0006033 name: ARNT2_HUMAN def: "Aryl hydrocarbon receptor nuclear translocator 2" [UniProtKB:Q9HBZ2] synonym: "ARNT protein 2" EXACT [UniProtKB:Q9HBZ2] xref: EMBL:AAG15310.1 xref: EMBL:AAH36099.1 xref: EMBL:BAA20766.2 xref: UniProtKB:O15024 xref: UniProtKB:Q8IYC2 xref: UniProtKB:Q9HBZ2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004098 ! ARNT2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006034 name: JIP3_HUMAN def: "C-jun-amino-terminal kinase-interacting protein 3" [UniProtKB:Q9UPT6] synonym: "JIP-3" EXACT [UniProtKB:Q9UPT6] synonym: "JNK MAP kinase scaffold protein 3" EXACT [UniProtKB:Q9UPT6] synonym: "JNK-interacting protein 3" EXACT [UniProtKB:Q9UPT6] synonym: "Mitogen-activated protein kinase 8-interacting protein 3" EXACT [UniProtKB:Q9UPT6] xref: EMBL:AAK61290.1 xref: EMBL:BAA83018.2 xref: EMBL:BAB15727.1 xref: EMBL:CAB72318.1 xref: EMBL:CAM26364.1 xref: EMBL:CAM26394.1 xref: UniProtKB:A2A2B3 xref: UniProtKB:Q96RY4 xref: UniProtKB:Q9H4I4 xref: UniProtKB:Q9H7P1 xref: UniProtKB:Q9NUG0 xref: UniProtKB:Q9UPT6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004911 ! MAPK8IP3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0012440 ! JIP3_HUMAN-Phosphothreonine265 relationship: transforms_into CCO:B0012441 ! JIP3_HUMAN-Phosphoserine267 relationship: transforms_into CCO:B0012442 ! JIP3_HUMAN-Phosphothreonine275 relationship: transforms_into CCO:B0012443 ! JIP3_HUMAN-Phosphothreonine286 relationship: transforms_into CCO:B0012444 ! JIP3_HUMAN-Phosphoserine365 relationship: transforms_into CCO:B0012445 ! JIP3_HUMAN-Phosphoserine585 relationship: transforms_into CCO:B0012446 ! JIP3_HUMAN-Phosphoserine676 [Term] id: CCO:B0006035 name: PR285_HUMAN def: "Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein" [UniProtKB:Q9BYK8] synonym: "ATP-dependent helicase PRIC285" EXACT [UniProtKB:Q9BYK8] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9BYK8] synonym: "PDIP1" EXACT [UniProtKB:Q9BYK8] synonym: "PPAR-alpha-interacting complex protein 285" EXACT [UniProtKB:Q9BYK8] synonym: "PPAR-gamma DBD-interacting protein 1" EXACT [UniProtKB:Q9BYK8] synonym: "PPAR-gamma DNA-binding domain-interacting protein 1" EXACT [UniProtKB:Q9BYK8] xref: EMBL:AAM74197.1 xref: EMBL:BAB21860.2 xref: EMBL:BAB70969.1 xref: EMBL:BAB84997.1 xref: EMBL:BAE46995.1 xref: EMBL:CAI95749.1 xref: UniProtKB:Q3C2G2 xref: UniProtKB:Q4VXQ1 xref: UniProtKB:Q8TEF3 xref: UniProtKB:Q96ND3 xref: UniProtKB:Q9BYK8 xref: UniProtKB:Q9C094 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005372 ! PRIC285_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0013607 ! PR285_HUMAN-Phosphoserine338 [Term] id: CCO:B0006036 name: ERCC5_HUMAN def: "DNA-repair protein complementing XP-G cells" [UniProtKB:P28715] synonym: "DNA excision repair protein ERCC-5" EXACT [UniProtKB:P28715] synonym: "Xeroderma pigmentosum group G-complementing protein" EXACT [UniProtKB:P28715] xref: EMBL:AAC37533.1 xref: EMBL:AAF89179.1 xref: EMBL:AAH31522.1 xref: EMBL:AAN46091.1 xref: EMBL:AAP97715.1 xref: EMBL:BAA03812.1 xref: EMBL:CAA49598.1 xref: EMBL:CAA50481.1 xref: UniProtKB:P28715 xref: UniProtKB:Q7Z2V3 xref: UniProtKB:Q8IZL6 xref: UniProtKB:Q8N1B7 xref: UniProtKB:Q9HD59 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004580 ! ERCC5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0011745 ! ERCC5_HUMAN-Phosphoserine156 relationship: transforms_into CCO:B0011746 ! ERCC5_HUMAN-Phosphoserine157 relationship: transforms_into CCO:B0011747 ! ERCC5_HUMAN-Phosphothreonine338 relationship: transforms_into CCO:B0011748 ! ERCC5_HUMAN-Phosphoserine341 relationship: transforms_into CCO:B0011749 ! ERCC5_HUMAN-Phosphoserine355 relationship: transforms_into CCO:B0011750 ! ERCC5_HUMAN-Phosphoserine356 relationship: transforms_into CCO:B0011751 ! ERCC5_HUMAN-Phosphoserine357 relationship: transforms_into CCO:B0011752 ! ERCC5_HUMAN-Phosphoserine384 relationship: transforms_into CCO:B0011753 ! ERCC5_HUMAN-Phosphoserine428 relationship: transforms_into CCO:B0011754 ! ERCC5_HUMAN-Phosphoserine526 relationship: transforms_into CCO:B0011755 ! ERCC5_HUMAN-Phosphoserine563 relationship: transforms_into CCO:B0011756 ! ERCC5_HUMAN-Phosphoserine705 relationship: transforms_into CCO:B0011757 ! ERCC5_HUMAN-Phosphoserine724 [Term] id: CCO:B0006037 name: PAR12_HUMAN def: "Poly [ADP-ribose] polymerase 12" [UniProtKB:Q9H0J9] synonym: "EC 2.4.2.30" EXACT [UniProtKB:Q9H0J9] synonym: "PARP-12" EXACT [UniProtKB:Q9H0J9] synonym: "Zinc finger CCCH domain-containing protein 1" EXACT [UniProtKB:Q9H0J9] xref: EMBL:AAF66161.1 xref: EMBL:AAH81541.1 xref: EMBL:AAS00360.1 xref: EMBL:BAB15457.1 xref: EMBL:CAB66700.1 xref: EMBL:CAB70657.1 xref: UniProtKB:Q9H0J9 xref: UniProtKB:Q9H610 xref: UniProtKB:Q9NP36 xref: UniProtKB:Q9NTI3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005259 ! PARP12_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006038 name: NKRF_HUMAN def: "NF-kappa-B-repressing factor" [UniProtKB:O15226] synonym: "ITBA4 protein" EXACT [UniProtKB:O15226] synonym: "NFkB-repressing factor" EXACT [UniProtKB:O15226] synonym: "Transcription factor NRF" EXACT [UniProtKB:O15226] xref: EMBL:AAH40379.1 xref: EMBL:AAH47878.1 xref: EMBL:AAP43025.1 xref: EMBL:CAA68976.1 xref: EMBL:CAB56459.1 xref: UniProtKB:O15226 xref: UniProtKB:Q4VC41 xref: UniProtKB:Q9UJ91 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005198 ! NKRF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006039 name: SMO_HUMAN def: "Smoothened homolog precursor" [UniProtKB:Q99835] synonym: "Gx protein" EXACT [UniProtKB:Q99835] synonym: "SMO" EXACT [UniProtKB:Q99835] xref: EMBL:AAB41788.1 xref: EMBL:AAC24863.1 xref: EMBL:AAD17202.1 xref: EMBL:AAF31757.1 xref: EMBL:AAH09989.1 xref: UniProtKB:Q99835 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005635 ! SMO_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006040 name: OLA1_HUMAN def: "Obg-like ATPase 1" [UniProtKB:Q9NTK5] synonym: "EC 3.6.3.-" EXACT [UniProtKB:Q9NTK5] synonym: "GTP-binding protein 9" EXACT [UniProtKB:Q9NTK5] xref: EMBL:AAD44491.1 xref: EMBL:AAD44500.1 xref: EMBL:AAF71123.1 xref: EMBL:AAH12842.1 xref: EMBL:AAH13925.1 xref: EMBL:AAH29376.1 xref: EMBL:AAH91522.1 xref: EMBL:AAP97255.1 xref: EMBL:BAB55174.1 xref: EMBL:BAC11153.1 xref: EMBL:CAB66481.1 xref: UniProtKB:Q5BJD7 xref: UniProtKB:Q8NCI8 xref: UniProtKB:Q96CU1 xref: UniProtKB:Q96SV2 xref: UniProtKB:Q9NTK5 xref: UniProtKB:Q9P1D3 xref: UniProtKB:Q9UNY9 xref: UniProtKB:Q9Y6G4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005231 ! OLA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006041 name: TBL1R_HUMAN def: "F-box-like/WD repeat-containing protein TBL1XR1" [UniProtKB:Q9BZK7] synonym: "Nuclear receptor corepressor/HDAC3 complex subunit TBLR1" EXACT [UniProtKB:Q9BZK7] synonym: "TBL1-related protein 1" EXACT [UniProtKB:Q9BZK7] synonym: "Transducin beta-like 1X-related protein 1" EXACT [UniProtKB:Q9BZK7] xref: EMBL:AAG44736.1 xref: EMBL:AAH60320.1 xref: EMBL:AAI13422.1 xref: EMBL:AAK00301.1 xref: EMBL:BAB14331.1 xref: UniProtKB:Q14DC3 xref: UniProtKB:Q9BZK7 xref: UniProtKB:Q9H2I1 xref: UniProtKB:Q9H9A1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005742 ! TBL1XR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0014319 ! TBL1R_HUMAN-Phosphoserine119 [Term] id: CCO:B0006042 name: MINT_HUMAN def: "Msx2-interacting protein" [UniProtKB:Q96T58] synonym: "SMART/HDAC1-associated repressor protein" EXACT [UniProtKB:Q96T58] synonym: "SPEN homolog" EXACT [UniProtKB:Q96T58] xref: EMBL:AAK52750.1 xref: EMBL:BAA76773.1 xref: EMBL:BAA91405.1 xref: EMBL:BAB14324.1 xref: EMBL:CAB51072.1 xref: EMBL:CAH70858.1 xref: EMBL:CAI19526.1 xref: UniProtKB:Q96T58 xref: UniProtKB:Q9H9A8 xref: UniProtKB:Q9NWH5 xref: UniProtKB:Q9UQ01 xref: UniProtKB:Q9Y556 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005087 ! SPEN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0012917 ! MINT_HUMAN-Phosphoserine260 relationship: transforms_into CCO:B0012918 ! MINT_HUMAN-Phosphoserine263 relationship: transforms_into CCO:B0012919 ! MINT_HUMAN-Phosphothreonine266 relationship: transforms_into CCO:B0012920 ! MINT_HUMAN-Phosphoserine725 relationship: transforms_into CCO:B0012921 ! MINT_HUMAN-Phosphoserine727 relationship: transforms_into CCO:B0012922 ! MINT_HUMAN-Phosphoserine736 relationship: transforms_into CCO:B0012923 ! MINT_HUMAN-Phosphoserine740 relationship: transforms_into CCO:B0012924 ! MINT_HUMAN-Phosphoserine1261 relationship: transforms_into CCO:B0012925 ! MINT_HUMAN-Phosphoserine1268 relationship: transforms_into CCO:B0012926 ! MINT_HUMAN-Phosphoserine1278 relationship: transforms_into CCO:B0012927 ! MINT_HUMAN-Phosphoserine1283 relationship: transforms_into CCO:B0012928 ! MINT_HUMAN-Phosphoserine1380 relationship: transforms_into CCO:B0012929 ! MINT_HUMAN-Phosphoserine1382 relationship: transforms_into CCO:B0012930 ! MINT_HUMAN-Phosphothreonine1619 relationship: transforms_into CCO:B0012931 ! MINT_HUMAN-Phosphoserine1797 relationship: transforms_into CCO:B0012932 ! MINT_HUMAN-Phosphoserine1857 relationship: transforms_into CCO:B0012933 ! MINT_HUMAN-Phosphoserine2101 relationship: transforms_into CCO:B0012934 ! MINT_HUMAN-Phosphoserine2120 relationship: transforms_into CCO:B0012935 ! MINT_HUMAN-Phosphoserine2126 relationship: transforms_into CCO:B0012936 ! MINT_HUMAN-Phosphothreonine2393 [Term] id: CCO:B0006043 name: EDG4_HUMAN def: "Lysophosphatidic acid receptor Edg-4" [UniProtKB:Q9HBW0] synonym: "LPA receptor 2" EXACT [UniProtKB:Q9HBW0] synonym: "LPA-2" EXACT [UniProtKB:Q9HBW0] xref: EMBL:AAB61528.1 xref: EMBL:AAC27728.1 xref: EMBL:AAF43409.1 xref: EMBL:AAG28521.1 xref: EMBL:AAH25695.1 xref: EMBL:AAP84361.1 xref: UniProtKB:O00543 xref: UniProtKB:O43431 xref: UniProtKB:Q9HBW0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004544 ! EDG4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006044 name: CAC1A_HUMAN def: "Voltage-dependent P/Q-type calcium channel subunit alpha-1A" [UniProtKB:O00555] synonym: "BI" EXACT [UniProtKB:O00555] synonym: "Brain calcium channel I" EXACT [UniProtKB:O00555] synonym: "Calcium channel, L type, alpha-1 polypeptide isoform 4" EXACT [UniProtKB:O00555] synonym: "Voltage-gated calcium channel subunit alpha Cav2.1" EXACT [UniProtKB:O00555] xref: EMBL:AAB33068.1 xref: EMBL:AAB49674.1 xref: EMBL:AAB49675.1 xref: EMBL:AAB49676.1 xref: EMBL:AAB49677.1 xref: EMBL:AAB49678.1 xref: EMBL:AAB61612.1 xref: EMBL:AAB61613.1 xref: EMBL:AAB64179.1 xref: EMBL:AAC26839.1 xref: EMBL:CAA68172.1 xref: UniProtKB:O00555 xref: UniProtKB:P78510 xref: UniProtKB:P78511 xref: UniProtKB:Q16290 xref: UniProtKB:Q92690 xref: UniProtKB:Q99790 xref: UniProtKB:Q99791 xref: UniProtKB:Q99792 xref: UniProtKB:Q99793 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004205 ! CACNA1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0010873 ! CAC1A_HUMAN-Phosphoserine750 relationship: transforms_into CCO:B0010874 ! CAC1A_HUMAN-Phosphoserine1822 relationship: transforms_into CCO:B0010875 ! CAC1A_HUMAN-Phosphoserine2030 relationship: transforms_into CCO:B0010876 ! CAC1A_HUMAN-Phosphotyrosine2076 relationship: transforms_into CCO:B0010877 ! CAC1A_HUMAN-Phosphoserine2269 relationship: transforms_into CCO:B0010878 ! CAC1A_HUMAN-Phosphoserine2378 [Term] id: CCO:B0006045 name: P2RY9_HUMAN def: "Lysophosphatidic acid receptor 4" [UniProtKB:Q99677] synonym: "G-protein coupled receptor 23" EXACT [UniProtKB:Q99677] synonym: "LPA receptor 4" EXACT [UniProtKB:Q99677] synonym: "LPA-4" EXACT [UniProtKB:Q99677] synonym: "P2Y purinoceptor 9" EXACT [UniProtKB:Q99677] synonym: "P2Y5-like receptor" EXACT [UniProtKB:Q99677] synonym: "P2Y9" EXACT [UniProtKB:Q99677] synonym: "Purinergic receptor 9" EXACT [UniProtKB:Q99677] xref: EMBL:AAB62087.1 xref: EMBL:AAB62088.1 xref: EMBL:AAB66322.1 xref: EMBL:AAC51301.1 xref: EMBL:AAH69996.1 xref: EMBL:AAH74722.1 xref: EMBL:AAH95538.1 xref: EMBL:AAP58404.1 xref: EMBL:CAD18851.1 xref: UniProtKB:O15132 xref: UniProtKB:Q502U9 xref: UniProtKB:Q6NSP5 xref: UniProtKB:Q99677 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005242 ! GPR23_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006046 name: SAE1_HUMAN def: "SUMO-activating enzyme subunit 1" [UniProtKB:Q9UBE0] synonym: "Ubiquitin-like 1-activating enzyme E1A" EXACT [UniProtKB:Q9UBE0] xref: EMBL:AAD12785.2 xref: EMBL:AAD23902.2 xref: EMBL:AAD24433.1 xref: EMBL:AAF29104.1 xref: EMBL:AAH00344.1 xref: EMBL:AAH03611.1 xref: EMBL:AAH18271.1 xref: EMBL:AAP35954.1 xref: UniProtKB:O95717 xref: UniProtKB:Q9P020 xref: UniProtKB:Q9UBE0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005560 ! SAE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0013956 ! SAE1_HUMAN-Phosphoserine185 [Term] id: CCO:B0006047 name: WNT16_HUMAN def: "Protein Wnt-16 precursor" [UniProtKB:Q9UBV4] xref: EMBL:AAD38052.1 xref: EMBL:AAD49351.1 xref: EMBL:AAI04920.1 xref: EMBL:AAI04946.1 xref: UniProtKB:Q2M3G1 xref: UniProtKB:Q9UBV4 xref: UniProtKB:Q9Y5C0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005932 ! WNT16_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006048 name: HSF4_HUMAN def: "Heat shock factor protein 4" [UniProtKB:Q9ULV5] synonym: "Heat shock transcription factor 4" EXACT [UniProtKB:Q9ULV5] synonym: "hHSF4" EXACT [UniProtKB:Q9ULV5] synonym: "HSF 4" EXACT [UniProtKB:Q9ULV5] synonym: "HSTF 4" EXACT [UniProtKB:Q9ULV5] xref: EMBL:BAA13433.1 xref: EMBL:BAA84581.1 xref: EMBL:BAA84582.1 xref: UniProtKB:Q99472 xref: UniProtKB:Q9ULV5 xref: UniProtKB:Q9ULV6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004832 ! HSF4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006049 name: PO2F3_HUMAN def: "POU domain, class 2, transcription factor 3" [UniProtKB:Q9UKI9] synonym: "Oct-11" EXACT [UniProtKB:Q9UKI9] synonym: "Octamer-binding transcription factor 11" EXACT [UniProtKB:Q9UKI9] synonym: "PLA-1 protein" EXACT [UniProtKB:Q9UKI9] synonym: "Transcription factor Skn-1" EXACT [UniProtKB:Q9UKI9] xref: EMBL:AAD55245.1 xref: EMBL:AAF00199.1 xref: EMBL:CAB45383.1 xref: UniProtKB:Q9UKI9 xref: UniProtKB:Q9UKR7 xref: UniProtKB:Q9Y504 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005352 ! POU2F3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006050 name: UTP6_HUMAN def: "U3 small nucleolar RNA-associated protein 6 homolog" [UniProtKB:Q9NYH9] synonym: "Hepatocellular carcinoma-associated antigen 66" EXACT [UniProtKB:Q9NYH9] synonym: "Multiple hat domains protein" EXACT [UniProtKB:Q9NYH9] xref: EMBL:AAF66244.1 xref: EMBL:AAH15454.1 xref: EMBL:AAH35325.1 xref: EMBL:AAO15382.1 xref: EMBL:CAB77268.1 xref: UniProtKB:Q8IX96 xref: UniProtKB:Q96BL2 xref: UniProtKB:Q9NQ91 xref: UniProtKB:Q9NYH9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005891 ! UTP6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction [Term] id: CCO:B0006051 name: JHD1A_HUMAN def: "JmjC domain-containing histone demethylation protein 1A" [UniProtKB:Q9Y2K7] synonym: "[Histone-H3]-lysine-36 demethylase 1A" EXACT [UniProtKB:Q9Y2K7] synonym: "CXXC-type zinc finger protein 8" EXACT [UniProtKB:Q9Y2K7] synonym: "EC 1.14.11.27" EXACT [UniProtKB:Q9Y2K7] synonym: "F-box and leucine-rich repeat protein 11" EXACT [UniProtKB:Q9Y2K7] synonym: "F-box protein FBL7" EXACT [UniProtKB:Q9Y2K7] synonym: "F-box protein Lilina" EXACT [UniProtKB:Q9Y2K7] synonym: "F-box/LRR-repeat protein 11" EXACT [UniProtKB:Q9Y2K7] xref: EMBL:AAD56012.1 xref: EMBL:AAH01203.1 xref: EMBL:AAH47371.1 xref: EMBL:AAH47486.1 xref: EMBL:AAH64360.1 xref: EMBL:BAA76848.2 xref: EMBL:BAB15795.1 xref: EMBL:CAH10721.1 xref: UniProtKB:Q49A21 xref: UniProtKB:Q4G0M3 xref: UniProtKB:Q69YY8 xref: UniProtKB:Q9BVH5 xref: UniProtKB:Q9H7H5 xref: UniProtKB:Q9UK66 xref: UniProtKB:Q9Y2K7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004910 ! FBXL11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: participates_in CCO:I0008780 ! fbox11-skp1 physical interaction relationship: transforms_into CCO:B0012437 ! JHD1A_HUMAN-Phosphoserine28 relationship: transforms_into CCO:B0012438 ! JHD1A_HUMAN-Phosphothreonine534 relationship: transforms_into CCO:B0012439 ! JHD1A_HUMAN-Phosphothreonine632 [Term] id: CCO:B0006052 name: MTMR6_HUMAN def: "Myotubularin-related protein 6" [UniProtKB:Q9Y217] synonym: "EC 3.1.3.-" EXACT [UniProtKB:Q9Y217] xref: EMBL:AAC78841.1 xref: EMBL:AAH40012.1 xref: EMBL:AAL01037.1 xref: EMBL:CAD89918.1 xref: EMBL:CAI39897.1 xref: UniProtKB:Q5JRG6 xref: UniProtKB:Q86TB7 xref: UniProtKB:Q86YH4 xref: UniProtKB:Q96P80 xref: UniProtKB:Q9Y217 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005133 ! MTMR6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction relationship: transforms_into CCO:B0013035 ! MTMR6_HUMAN-Phosphoserine561 [Term] id: CCO:B0006053 name: CCD95_HUMAN def: "Coiled-coil domain-containing protein 95" [UniProtKB:Q8NBZ0] xref: EMBL:AAH47712.1 xref: EMBL:BAC11424.1 xref: UniProtKB:Q8NBZ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004238 ! CCDC95_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: participates_in CCO:I0007778 ! fj90652-ruvbl-1 physical interaction [Term] id: CCO:B0006055 name: ZNHI4_HUMAN def: "Zinc finger HIT domain-containing protein 4" [UniProtKB:Q9C086] synonym: "High mobility group AT-hook 1-like 4" EXACT [UniProtKB:Q9C086] synonym: "PAP-1-associated protein 1" EXACT [UniProtKB:Q9C086] synonym: "PAPA-1" EXACT [UniProtKB:Q9C086] xref: EMBL:AAH50666.1 xref: EMBL:AAH64425.1 xref: EMBL:BAB21111.1 xref: UniProtKB:Q9C086 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005971 ! ZNHIT4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: participates_in CCO:I0007774 ! znhit4-ruvbl-1 physical interaction [Term] id: CCO:B0006056 name: INOC1_HUMAN def: "Putative DNA helicase INO80 complex homolog 1" [UniProtKB:Q9ULG1] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9ULG1] synonym: "hINO80" EXACT [UniProtKB:Q9ULG1] xref: EMBL:BAA86573.1 xref: EMBL:CAB70675.1 xref: UniProtKB:Q9NTG6 xref: UniProtKB:Q9ULG1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004898 ! INOC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction relationship: transforms_into CCO:B0041153 ! INOC1_HUMAN-Phosphothreonine1550 [Term] id: CCO:B0006057 name: TFE2_HUMAN def: "Transcription factor E2-alpha" [UniProtKB:P15923] synonym: "Immunoglobulin enhancer-binding factor E12/E47" EXACT [UniProtKB:P15923] synonym: "Immunoglobulin transcription factor 1" EXACT [UniProtKB:P15923] synonym: "Kappa-E2-binding factor" EXACT [UniProtKB:P15923] synonym: "TCF-3" EXACT [UniProtKB:P15923] synonym: "Transcription factor 3" EXACT [UniProtKB:P15923] synonym: "Transcription factor ITF-1" EXACT [UniProtKB:P15923] xref: EMBL:AAA36764.1 xref: EMBL:AAA52331.1 xref: EMBL:AAA56829.1 xref: EMBL:AAA56830.1 xref: EMBL:AAA61146.1 xref: EMBL:AAC27373.1 xref: EMBL:AAC41693.1 xref: EMBL:AAC99797.1 xref: EMBL:CAA36297.1 xref: UniProtKB:P15883 xref: UniProtKB:P15923 xref: UniProtKB:Q14208 xref: UniProtKB:Q14635 xref: UniProtKB:Q14636 xref: UniProtKB:Q9UPI9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005771 ! TCF3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction [Term] id: CCO:B0006058 name: ARP8_HUMAN def: "Actin-related protein 8" [UniProtKB:Q9H981] xref: EMBL:BAB14352.1 xref: EMBL:BAB15402.1 xref: UniProtKB:Q9H663 xref: UniProtKB:Q9H981 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004101 ! ACTR8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007775 ! actr8-ruvbl physical interaction relationship: transforms_into CCO:B0010604 ! ARP8_HUMAN-Phosphoserine132 [Term] id: CCO:B0006061 name: BCL9_HUMAN def: "B-cell CLL/lymphoma 9 protein" [UniProtKB:O00512] synonym: "B-cell lymphoma 9 protein" EXACT [UniProtKB:O00512] synonym: "Bcl-9" EXACT [UniProtKB:O00512] synonym: "Protein legless homolog" EXACT [UniProtKB:O00512] xref: EMBL:CAA73942.1 xref: UniProtKB:O00512 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004154 ! BCL9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007791 ! cdc73-ctnnb1-6 physical interaction relationship: transforms_into CCO:B0010774 ! BCL9_HUMAN-Phosphothreonine315 relationship: transforms_into CCO:B0010775 ! BCL9_HUMAN-Phosphoserine318 relationship: transforms_into CCO:B0010776 ! BCL9_HUMAN-Phosphoserine352 relationship: transforms_into CCO:B0010777 ! BCL9_HUMAN-Phosphoserine687 [Term] id: CCO:B0006062 name: PYGO2_HUMAN def: "Pygopus homolog 2" [UniProtKB:Q9BRQ0] xref: EMBL:AAH06132.2 xref: EMBL:AAH13725.1 xref: EMBL:AAH32099.1 xref: EMBL:AAL55782.1 xref: EMBL:AAL91371.1 xref: UniProtKB:Q8WYZ4 xref: UniProtKB:Q96CY2 xref: UniProtKB:Q9BRQ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005404 ! PYGO2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007792 ! cdc73-ctnnb1-7 physical interaction relationship: transforms_into CCO:B0013651 ! PYGO2_HUMAN-Phosphoserine97 relationship: transforms_into CCO:B0013652 ! PYGO2_HUMAN-Phosphothreonine302 [Term] id: CCO:B0006063 name: ST5_HUMAN def: "Suppression of tumorigenicity 5" [UniProtKB:P78524] synonym: "DENN domain-containing protein 2B" EXACT [UniProtKB:P78524] synonym: "HeLa tumor suppression 1" EXACT [UniProtKB:P78524] xref: EMBL:AAB23647.1 xref: EMBL:AAB97097.1 xref: EMBL:AAC50925.1 xref: EMBL:AAC50926.1 xref: EMBL:AAH36655.1 xref: EMBL:CAC35387.1 xref: UniProtKB:P78523 xref: UniProtKB:P78524 xref: UniProtKB:Q16492 xref: UniProtKB:Q7KYY2 xref: UniProtKB:Q7KZ12 xref: UniProtKB:Q8NE12 xref: UniProtKB:Q9BQQ6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005678 ! ST5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007799 ! st5-abl1-1 physical interaction relationship: transforms_into CCO:B0014232 ! ST5_HUMAN-Phosphoserine1011 relationship: transforms_into CCO:B0014233 ! ST5_HUMAN-Phosphoserine1013 relationship: transforms_into CCO:B0014234 ! ST5_HUMAN-Phosphoserine1015 [Term] id: CCO:B0006064 name: CASC5_HUMAN def: "Protein CASC5" [UniProtKB:Q8NG31] synonym: "AF15q14" EXACT [UniProtKB:Q8NG31] synonym: "ALL1-fused gene from chromosome 15q14" EXACT [UniProtKB:Q8NG31] synonym: "Cancer susceptibility candidate gene 5 protein" EXACT [UniProtKB:Q8NG31] synonym: "Cancer/testis antigen 29" EXACT [UniProtKB:Q8NG31] synonym: "CT29" EXACT [UniProtKB:Q8NG31] synonym: "Protein D40/AF15q14" EXACT [UniProtKB:Q8NG31] xref: EMBL:AAF97513.1 xref: EMBL:AAL67803.1 xref: EMBL:AAM45143.1 xref: EMBL:BAB13396.1 xref: EMBL:BAC05691.1 xref: UniProtKB:Q8NG31 xref: UniProtKB:Q8NHE1 xref: UniProtKB:Q8WXA6 xref: UniProtKB:Q9HCK2 xref: UniProtKB:Q9NR92 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004220 ! CASC5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction relationship: transforms_into CCO:B0010915 ! CASC5_HUMAN-Phosphoserine32 relationship: transforms_into CCO:B0010916 ! CASC5_HUMAN-Phosphoserine60 relationship: transforms_into CCO:B0010917 ! CASC5_HUMAN-Phosphoserine765 relationship: transforms_into CCO:B0010918 ! CASC5_HUMAN-Phosphoserine767 relationship: transforms_into CCO:B0010919 ! CASC5_HUMAN-Phosphoserine956 relationship: transforms_into CCO:B0010920 ! CASC5_HUMAN-Phosphoserine1039 relationship: transforms_into CCO:B0010921 ! CASC5_HUMAN-Phosphothreonine1042 relationship: transforms_into CCO:B0010922 ! CASC5_HUMAN-Phosphoserine1076 relationship: transforms_into CCO:B0010923 ! CASC5_HUMAN-Phosphoserine1773 [Term] id: CCO:B0006066 name: CS025_HUMAN def: "UPF0449 protein C19orf25" [UniProtKB:Q9UFG5] xref: EMBL:AAH18441.1 xref: EMBL:BAC04262.1 xref: EMBL:CAB59260.2 xref: UniProtKB:Q8N9R7 xref: UniProtKB:Q8WV94 xref: UniProtKB:Q9UFG5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004400 ! C19orf25_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007819 ! zw10_zwilch_1 physical interaction relationship: transforms_into CCO:B0031306 ! CS025_HUMAN-Phosphotyrosine63 [Term] id: CCO:B0006067 name: NTF2_HUMAN def: "Nuclear transport factor 2" [UniProtKB:P61970] synonym: "NTF-2" EXACT [UniProtKB:P61970] synonym: "Placental protein 15" EXACT [UniProtKB:P61970] synonym: "PP15" EXACT [UniProtKB:P61970] xref: EMBL:AAA85905.1 xref: EMBL:AAH02348.1 xref: EMBL:CAA30278.1 xref: EMBL:CAG33218.1 xref: UniProtKB:P13662 xref: UniProtKB:P61970 xref: UniProtKB:Q6IB67 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005218 ! NUTF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007861 ! cdn1b-kpna3-3 physical interaction relationship: participates_in CCO:I0007862 ! cdn1b-kpna5-5 physical interaction [Term] id: CCO:B0006068 name: PKN1_HUMAN def: "Serine/threonine-protein kinase N1" [UniProtKB:Q16512] synonym: "EC 2.7.11.13" EXACT [UniProtKB:Q16512] synonym: "Protein kinase C-like 1" EXACT [UniProtKB:Q16512] synonym: "Protein kinase C-like PKN" EXACT [UniProtKB:Q16512] synonym: "Protein kinase PKN-alpha" EXACT [UniProtKB:Q16512] synonym: "Protein-kinase C-related kinase 1" EXACT [UniProtKB:Q16512] synonym: "Serine-threonine protein kinase N" EXACT [UniProtKB:Q16512] xref: EMBL:AAB33345.1 xref: EMBL:AAC50209.1 xref: EMBL:AAH40061.1 xref: EMBL:BAA05169.1 xref: UniProtKB:Q15143 xref: UniProtKB:Q16512 xref: UniProtKB:Q8IUV5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005329 ! PKN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007865 ! pkn1-mapk12-1 physical interaction relationship: participates_in CCO:I0007866 ! pkn1-mapk12-2 physical interaction relationship: participates_in CCO:I0007867 ! pkn1-map2k6-2 physical interaction relationship: transforms_into CCO:B0013547 ! PKN1_HUMAN-Phosphoserine376 relationship: transforms_into CCO:B0013548 ! PKN1_HUMAN-Phosphoserine562 relationship: transforms_into CCO:B0013549 ! PKN1_HUMAN-Phosphothreonine774 relationship: transforms_into CCO:B0013550 ! PKN1_HUMAN-Phosphoserine916 [Term] id: CCO:B0006069 name: PO2F1_HUMAN def: "POU domain, class 2, transcription factor 1" [UniProtKB:P14859] synonym: "NF-A1" EXACT [UniProtKB:P14859] synonym: "Oct-1" EXACT [UniProtKB:P14859] synonym: "Octamer-binding transcription factor 1" EXACT [UniProtKB:P14859] synonym: "OTF-1" EXACT [UniProtKB:P14859] xref: EMBL:AAH01664.1 xref: EMBL:AAH03571.1 xref: EMBL:AAH07388.1 xref: EMBL:AAH52274.1 xref: EMBL:AAM77920.1 xref: EMBL:CAA31767.1 xref: EMBL:CAI15170.1 xref: EMBL:CAI15171.1 xref: UniProtKB:P14859 xref: UniProtKB:Q5TBT7 xref: UniProtKB:Q6PK46 xref: UniProtKB:Q8NEU9 xref: UniProtKB:Q9BPV1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005351 ! POU2F1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007872 ! hcfc1-pou2f1-1 physical interaction relationship: transforms_into CCO:B0013593 ! PO2F1_HUMAN-Phosphoserine448 [Term] id: CCO:B0006070 name: EGR2_HUMAN def: "Early growth response protein 2" [UniProtKB:P11161] synonym: "AT591" EXACT [UniProtKB:P11161] synonym: "EGR-2" EXACT [UniProtKB:P11161] synonym: "Protein Krox-20" EXACT [UniProtKB:P11161] xref: EMBL:AAA52372.1 xref: EMBL:AAD24588.1 xref: EMBL:AAH35625.1 xref: EMBL:CAH18435.1 xref: EMBL:CAH73827.2 xref: UniProtKB:P11161 xref: UniProtKB:Q68CZ5 xref: UniProtKB:Q8IV26 xref: UniProtKB:Q9UNA6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004554 ! EGR2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007873 ! hcfc1-egr2-1 physical interaction [Term] id: CCO:B0006071 name: P3C2A_HUMAN def: "Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide" [UniProtKB:O00443] synonym: "EC 2.7.1.154" EXACT [UniProtKB:O00443] synonym: "Phosphoinositide 3-Kinase-C2-alpha" EXACT [UniProtKB:O00443] synonym: "PI3K-C2alpha" EXACT [UniProtKB:O00443] synonym: "PtdIns-3-kinase C2 alpha" EXACT [UniProtKB:O00443] xref: EMBL:AAI13659.1 xref: EMBL:CAA73797.1 xref: UniProtKB:O00443 xref: UniProtKB:Q14CQ9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005243 ! PIK3C2A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007877 ! egfr-pik3c2a-1 physical interaction relationship: transforms_into CCO:B0013339 ! P3C2A_HUMAN-Phosphoserine259 [Term] id: CCO:B0006072 name: PPIA_HUMAN def: "Peptidyl-prolyl cis-trans isomerase A" [UniProtKB:P62937] synonym: "Cyclophilin A" EXACT [UniProtKB:P62937] synonym: "Cyclosporin A-binding protein" EXACT [UniProtKB:P62937] synonym: "EC 5.2.1.8" EXACT [UniProtKB:P62937] synonym: "PPIase A" EXACT [UniProtKB:P62937] synonym: "Rotamase A" EXACT [UniProtKB:P62937] xref: EMBL:AAH00689.1 xref: EMBL:AAH03026.2 xref: EMBL:AAH05320.1 xref: EMBL:AAH05982.1 xref: EMBL:AAH07104.1 xref: EMBL:AAH13915.1 xref: EMBL:AAH73992.1 xref: EMBL:AAI06031.1 xref: EMBL:AAU13906.1 xref: EMBL:CAA37039.1 xref: EMBL:CAA68264.1 xref: EMBL:CAG32988.1 xref: UniProtKB:P05092 xref: UniProtKB:P62937 xref: UniProtKB:Q3KQW3 xref: UniProtKB:Q6IBU5 xref: UniProtKB:Q96IX3 xref: UniProtKB:Q9BRU4 xref: UniProtKB:Q9BTY9 xref: UniProtKB:Q9UC61 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005364 ! PPIA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007885 ! supt5h-ppia-1 physical interaction relationship: participates_in CCO:I0008332 ! supt5h-ppia physical interaction relationship: transforms_into CCO:B0013600 ! PPIA_HUMAN-N-acetylvaline2 relationship: transforms_into CCO:B0013601 ! PPIA_HUMAN-Phosphoserine21 relationship: transforms_into CCO:B0013602 ! PPIA_HUMAN-N6-acetyllysine125 relationship: transforms_into CCO:B0013603 ! PPIA_HUMAN-Phosphothreonine157 [Term] id: CCO:B0006073 name: AN32A_HUMAN def: "Acidic leucine-rich nuclear phosphoprotein 32 family member A" [UniProtKB:P39687] synonym: "Acidic nuclear phosphoprotein pp32" EXACT [UniProtKB:P39687] synonym: "Lanp" EXACT [UniProtKB:P39687] synonym: "Leucine-rich acidic nuclear protein" EXACT [UniProtKB:P39687] synonym: "Mapmodulin" EXACT [UniProtKB:P39687] synonym: "PHAPI" EXACT [UniProtKB:P39687] synonym: "Potent heat-stable protein phosphatase 2A inhibitor I1PP2A" EXACT [UniProtKB:P39687] synonym: "Putative HLA-DR-associated protein I" EXACT [UniProtKB:P39687] xref: EMBL:AAB39706.1 xref: EMBL:AAB91548.1 xref: EMBL:AAC50570.1 xref: EMBL:AAH07200.1 xref: EMBL:AAP36104.1 xref: EMBL:CAA52981.1 xref: UniProtKB:P39687 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004052 ! ANP32A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007886 ! axin1-anp32a-1 physical interaction relationship: participates_in CCO:I0008071 ! axin1-anp32a physical interaction relationship: transforms_into CCO:B0010509 ! AN32A_HUMAN-Phosphoserine158 [Term] id: CCO:B0006074 name: DPYL1_HUMAN def: "Dihydropyrimidinase-related protein 1" [UniProtKB:Q14194] synonym: "Collapsin response mediator protein 1" EXACT [UniProtKB:Q14194] synonym: "CRMP-1" EXACT [UniProtKB:Q14194] synonym: "DRP-1" EXACT [UniProtKB:Q14194] xref: EMBL:AAA93201.1 xref: EMBL:AAH00252.1 xref: EMBL:AAH07613.1 xref: EMBL:AAK55500.1 xref: EMBL:AAP35452.1 xref: EMBL:BAA11190.1 xref: UniProtKB:Q13024 xref: UniProtKB:Q14194 xref: UniProtKB:Q96TC8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004510 ! CRMP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007887 ! axin1-crmp1 physical interaction relationship: participates_in CCO:I0007997 ! axin1-crmp1-1 physical interaction relationship: participates_in CCO:I0008237 ! smpd3-crmp1 physical interaction relationship: participates_in CCO:I0008292 ! pmf1-crmp1 physical interaction relationship: participates_in CCO:I0008370 ! cdk5rap3-crmp1 physical interaction relationship: transforms_into CCO:B0011581 ! DPYL1_HUMAN-Phosphothreonine509 relationship: transforms_into CCO:B0031312 ! DPYL1_HUMAN-Phosphotyrosine431 relationship: transforms_into CCO:B0031313 ! DPYL1_HUMAN-Phosphotyrosine504 [Term] id: CCO:B0006076 name: CNBP1_HUMAN def: "Beta-catenin-interacting protein 1" [UniProtKB:Q9NSA3] synonym: "Inhibitor of beta-catenin and Tcf-4" EXACT [UniProtKB:Q9NSA3] xref: EMBL:AAH14300.1 xref: EMBL:BAB03458.1 xref: UniProtKB:Q9NSA3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004375 ! CTNNBIP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007942 ! apc-ctnnb1-1 physical interaction [Term] id: CCO:B0006077 name: EPAS1_HUMAN def: "Endothelial PAS domain-containing protein 1" [UniProtKB:Q99814] synonym: "Basic-helix-loop-helix-PAS protein MOP2" EXACT [UniProtKB:Q99814] synonym: "EPAS-1" EXACT [UniProtKB:Q99814] synonym: "HIF-1 alpha-like factor" EXACT [UniProtKB:Q99814] synonym: "HIF-2 alpha" EXACT [UniProtKB:Q99814] synonym: "HIF2 alpha" EXACT [UniProtKB:Q99814] synonym: "HLF" EXACT [UniProtKB:Q99814] synonym: "Hypoxia-inducible factor 2 alpha" EXACT [UniProtKB:Q99814] synonym: "Member of PAS protein 2" EXACT [UniProtKB:Q99814] xref: EMBL:AAB41495.1 xref: EMBL:AAC51212.1 xref: EMBL:AAH51338.1 xref: UniProtKB:Q86VA2 xref: UniProtKB:Q99630 xref: UniProtKB:Q99814 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004570 ! EPAS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007956 ! epas1-ep300-1 physical interaction relationship: transforms_into CCO:B0011715 ! EPAS1_HUMAN-4-hydroxyproline405 relationship: transforms_into CCO:B0011716 ! EPAS1_HUMAN-4-hydroxyproline531 relationship: transforms_into CCO:B0011717 ! EPAS1_HUMAN-Phosphothreonine840 relationship: transforms_into CCO:B0011718 ! EPAS1_HUMAN-3-hydroxyasparagine847 [Term] id: CCO:B0006078 name: PCNT_HUMAN def: "Pericentrin" [UniProtKB:O95613] synonym: "Kendrin" EXACT [UniProtKB:O95613] synonym: "Pericentrin B" EXACT [UniProtKB:O95613] xref: EMBL:AAD10838.1 xref: EMBL:AAP46636.1 xref: EMBL:BAA23698.3 xref: EMBL:BAC04252.1 xref: UniProtKB:O43152 xref: UniProtKB:O95613 xref: UniProtKB:Q7Z7C9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005280 ! PCNT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007970 ! disc1-tubg-1 physical interaction relationship: transforms_into CCO:B0013439 ! PCNT_HUMAN-Phosphoserine1703 [Term] id: CCO:B0006079 name: EF1G_HUMAN def: "Elongation factor 1-gamma" [UniProtKB:P26641] synonym: "eEF-1B gamma" EXACT [UniProtKB:P26641] synonym: "EF-1-gamma" EXACT [UniProtKB:P26641] xref: EMBL:AAC18414.1 xref: EMBL:AAF69604.1 xref: EMBL:AAH00384.1 xref: EMBL:AAH06509.1 xref: EMBL:AAH06520.1 xref: EMBL:AAH07949.2 xref: EMBL:AAH09865.1 xref: EMBL:AAH13918.1 xref: EMBL:AAH15813.1 xref: EMBL:AAH21974.2 xref: EMBL:AAH28179.1 xref: EMBL:AAH31012.1 xref: EMBL:AAH67738.1 xref: EMBL:CAA45089.1 xref: EMBL:CAA77630.1 xref: UniProtKB:P26641 xref: UniProtKB:Q6PJ62 xref: UniProtKB:Q6PK31 xref: UniProtKB:Q96CU2 xref: UniProtKB:Q9P196 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004547 ! EEF1G_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007986 ! dleu1-eef1g physical interaction relationship: participates_in CCO:I0008375 ! chfr-eef1g physical interaction relationship: transforms_into CCO:B0011648 ! EF1G_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0011649 ! EF1G_HUMAN-Phosphothreonine43 [Term] id: CCO:B0006080 name: UN119_HUMAN def: "Protein unc-119 homolog" [UniProtKB:Q13432] synonym: "hRG4" EXACT [UniProtKB:Q13432] synonym: "Retinal protein 4" EXACT [UniProtKB:Q13432] xref: EMBL:AAC50360.1 xref: EMBL:AAD01875.1 xref: EMBL:AAD01876.1 xref: EMBL:AAD31422.1 xref: EMBL:AAH27176.1 xref: UniProtKB:O95126 xref: UniProtKB:Q13432 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005883 ! UNC119_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007983 ! cdkn2c-unc119 physical interaction relationship: participates_in CCO:I0008007 ! cks2-unc119 physical interaction relationship: participates_in CCO:I0008039 ! psmd2-unc119 physical interaction relationship: participates_in CCO:I0008087 ! cetn3-unc119 physical interaction relationship: participates_in CCO:I0008135 ! mphosph6-unc119 physical interaction relationship: participates_in CCO:I0008182 ! tp53bp2-unc119 physical interaction relationship: participates_in CCO:I0008184 ! ube2i-unc119 physical interaction relationship: transforms_into CCO:B0014580 ! UN119_HUMAN-Phosphoserine37 [Term] id: CCO:B0006081 name: CBPE_HUMAN def: "Carboxypeptidase E precursor" [UniProtKB:P16870] synonym: "Carboxypeptidase H" EXACT [UniProtKB:P16870] synonym: "CPE" EXACT [UniProtKB:P16870] synonym: "CPH" EXACT [UniProtKB:P16870] synonym: "EC 3.4.17.10" EXACT [UniProtKB:P16870] synonym: "Enkephalin convertase" EXACT [UniProtKB:P16870] synonym: "Prohormone-processing carboxypeptidase" EXACT [UniProtKB:P16870] xref: EMBL:AAH33866.1 xref: EMBL:AAH53612.1 xref: EMBL:BAA86053.1 xref: EMBL:CAA35767.1 xref: UniProtKB:P16870 xref: UniProtKB:Q9UIU9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004229 ! CPE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007984 ! cpe-rif1 physical interaction [Term] id: CCO:B0006082 name: CHD3_HUMAN def: "Chromodomain-helicase-DNA-binding protein 3" [UniProtKB:Q12873] synonym: "ATP-dependent helicase CHD3" EXACT [UniProtKB:Q12873] synonym: "CHD-3" EXACT [UniProtKB:Q12873] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q12873] synonym: "hZFH" EXACT [UniProtKB:Q12873] synonym: "Mi-2 autoantigen 240 kDa protein" EXACT [UniProtKB:Q12873] synonym: "Mi2-alpha" EXACT [UniProtKB:Q12873] synonym: "Zinc finger helicase" EXACT [UniProtKB:Q12873] xref: EMBL:AAB87383.1 xref: EMBL:AAC39923.1 xref: EMBL:AAC50228.1 xref: UniProtKB:Q12873 xref: UniProtKB:Q9Y4I0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004344 ! CHD3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008041 ! rad51-chd3 physical interaction relationship: participates_in CCO:I0008111 ! gps2-chd3 physical interaction relationship: participates_in CCO:I0008126 ! kif15-chd3 physical interaction relationship: participates_in CCO:I0008348 ! ube1c-chd3 physical interaction relationship: participates_in CCO:I0008796 ! psme1-chd3 physical interaction relationship: transforms_into CCO:B0011200 ! CHD3_HUMAN-Phosphoserine324 relationship: transforms_into CCO:B0011201 ! CHD3_HUMAN-Phosphoserine713 relationship: transforms_into CCO:B0011202 ! CHD3_HUMAN-Phosphoserine1601 relationship: transforms_into CCO:B0011203 ! CHD3_HUMAN-Phosphoserine1605 relationship: transforms_into CCO:B0035992 ! CHD3_HUMAN-Phosphoserine43 [Term] id: CCO:B0006083 name: SBP1_HUMAN def: "Selenium-binding protein 1" [UniProtKB:Q13228] synonym: "56 kDa selenium-binding protein" EXACT [UniProtKB:Q13228] synonym: "SP56" EXACT [UniProtKB:Q13228] xref: EMBL:AAB02395.1 xref: EMBL:AAH09084.1 xref: EMBL:CAG33133.1 xref: EMBL:CAH70328.1 xref: EMBL:EAW53443.1 xref: UniProtKB:A6NML9 xref: UniProtKB:Q13228 xref: UniProtKB:Q96GX7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005568 ! SELENBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007991 ! selenbp1-rif1 physical interaction relationship: transforms_into CCO:B0013965 ! SBP1_HUMAN-Phosphoserine467 [Term] id: CCO:B0006085 name: ZNF24_HUMAN def: "Zinc finger protein 24" [UniProtKB:P17028] synonym: "Retinoic acid suppression protein A" EXACT [UniProtKB:P17028] synonym: "RSG-A" EXACT [UniProtKB:P17028] synonym: "Zinc finger and SCAN domain-containing protein 3" EXACT [UniProtKB:P17028] synonym: "Zinc finger protein 191" EXACT [UniProtKB:P17028] synonym: "Zinc finger protein KOX17" EXACT [UniProtKB:P17028] xref: EMBL:AAB37275.1 xref: EMBL:AAB70216.1 xref: EMBL:AAD19827.1 xref: EMBL:AAH03566.1 xref: EMBL:AAH16801.1 xref: EMBL:CAA36574.1 xref: UniProtKB:O14754 xref: UniProtKB:P17028 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005968 ! ZNF24_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007993 ! znf24-tp53 physical interaction relationship: participates_in CCO:I0008062 ! znf24-rif1 physical interaction relationship: transforms_into CCO:B0014746 ! ZNF24_HUMAN-Phosphoserine261 relationship: transforms_into CCO:B0014747 ! ZNF24_HUMAN-Phosphotyrosine279 relationship: transforms_into CCO:B0014748 ! ZNF24_HUMAN-Phosphotyrosine335 [Term] id: CCO:B0006087 name: CCL18_HUMAN def: "C-C motif chemokine 18 precursor" [UniProtKB:P55774] synonym: "Alternative macrophage activation-associated CC chemokine 1" EXACT [UniProtKB:P55774] synonym: "AMAC-1" EXACT [UniProtKB:P55774] synonym: "CC chemokine PARC" EXACT [UniProtKB:P55774] synonym: "DC-CK1" EXACT [UniProtKB:P55774] synonym: "Dendritic cell chemokine 1" EXACT [UniProtKB:P55774] synonym: "Macrophage inflammatory protein 4" EXACT [UniProtKB:P55774] synonym: "MIP-4" EXACT [UniProtKB:P55774] synonym: "Pulmonary and activation-regulated chemokine" EXACT [UniProtKB:P55774] synonym: "Small-inducible cytokine A18" EXACT [UniProtKB:P55774] xref: EMBL:AAC32287.1 xref: EMBL:AAD30390.1 xref: EMBL:AAH69700.1 xref: EMBL:AAH96124.1 xref: EMBL:AAH96125.1 xref: EMBL:AAH96126.1 xref: EMBL:AAH96127.1 xref: EMBL:BAA21670.1 xref: EMBL:BAA34368.1 xref: EMBL:CAA74039.1 xref: EMBL:CAG28588.1 xref: UniProtKB:P55774 xref: UniProtKB:Q53X71 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004241 ! CCL18_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008000 ! ccl18-tp53 physical interaction [Term] id: CCO:B0006088 name: CPNS1_HUMAN def: "Calpain small subunit 1" [UniProtKB:P04632] synonym: "Calcium-activated neutral proteinase small subunit" EXACT [UniProtKB:P04632] synonym: "Calcium-dependent protease small subunit" EXACT [UniProtKB:P04632] synonym: "Calcium-dependent protease small subunit 1" EXACT [UniProtKB:P04632] synonym: "Calpain regulatory subunit" EXACT [UniProtKB:P04632] synonym: "CANP small subunit" EXACT [UniProtKB:P04632] synonym: "CDPS" EXACT [UniProtKB:P04632] synonym: "CSS1" EXACT [UniProtKB:P04632] xref: EMBL:AAA35646.1 xref: EMBL:AAB51183.1 xref: EMBL:AAB81546.1 xref: EMBL:AAH00592.1 xref: EMBL:AAH07779.1 xref: EMBL:AAH11903.1 xref: EMBL:AAH17308.1 xref: EMBL:AAH18931.1 xref: EMBL:AAH21933.1 xref: EMBL:AAH23643.1 xref: EMBL:AAH64998.1 xref: EMBL:AAP88777.1 xref: EMBL:AAV40829.1 xref: EMBL:CAA27726.1 xref: UniProtKB:P04632 xref: UniProtKB:Q8WTX3 xref: UniProtKB:Q96EW0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004391 ! CAPNS1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008004 ! cdk4-capns1 physical interaction relationship: participates_in CCO:I0008437 ! terf1-capns1 physical interaction relationship: transforms_into CCO:B0011338 ! CPNS1_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0006089 name: COX17_HUMAN def: "Cytochrome c oxidase copper chaperone" [UniProtKB:Q14061] xref: EMBL:AAA98114.1 xref: EMBL:AAF82569.1 xref: EMBL:AAH10933.1 xref: EMBL:AAI05281.1 xref: EMBL:AAI08318.1 xref: UniProtKB:Q14061 xref: UniProtKB:Q3MHD6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004386 ! COX17_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008008 ! cox17-rif1 physical interaction relationship: participates_in CCO:I0008089 ! cox17-tp53 physical interaction [Term] id: CCO:B0006090 name: IF2B_HUMAN def: "Eukaryotic translation initiation factor 2 subunit 2" [UniProtKB:P20042] synonym: "eIF-2-beta" EXACT [UniProtKB:P20042] synonym: "Eukaryotic translation initiation factor 2 subunit beta" EXACT [UniProtKB:P20042] xref: EMBL:AAA52383.1 xref: EMBL:AAH00461.1 xref: EMBL:AAH00934.1 xref: EMBL:CAB43741.1 xref: UniProtKB:P20042 xref: UniProtKB:Q9BVU0 xref: UniProtKB:Q9UJE4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004851 ! EIF2S2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008010 ! eif2s2-tp53 physical interaction relationship: transforms_into CCO:B0012302 ! IF2B_HUMAN-Phosphoserine2 relationship: transforms_into CCO:B0012303 ! IF2B_HUMAN-Phosphoserine67 [Term] id: CCO:B0006092 name: CH10_HUMAN def: "10 kDa heat shock protein, mitochondrial" [UniProtKB:P61604] synonym: "10 kDa chaperonin" EXACT [UniProtKB:P61604] synonym: "CPN10" EXACT [UniProtKB:P61604] synonym: "Early-pregnancy factor" EXACT [UniProtKB:P61604] synonym: "EPF" EXACT [UniProtKB:P61604] synonym: "Hsp10" EXACT [UniProtKB:P61604] xref: EMBL:AAA50953.1 xref: EMBL:AAC95387.1 xref: EMBL:AAH23518.1 xref: EMBL:CAA53455.1 xref: EMBL:CAB75425.1 xref: UniProtKB:O95421 xref: UniProtKB:P61604 xref: UniProtKB:Q04984 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004342 ! HSPE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008015 ! hspe1-rif1 physical interaction relationship: transforms_into CCO:B0011196 ! CH10_HUMAN-N-acetylalanine2 [Term] id: CCO:B0006093 name: LAMA4_HUMAN def: "Laminin subunit alpha-4 precursor" [UniProtKB:Q16363] xref: EMBL:AAB34635.1 xref: EMBL:BAE06109.1 xref: EMBL:CAA50261.1 xref: EMBL:CAA54258.1 xref: EMBL:CAA62596.1 xref: EMBL:CAA74636.1 xref: EMBL:CAI12950.1 xref: EMBL:CAI42325.1 xref: UniProtKB:Q14731 xref: UniProtKB:Q14735 xref: UniProtKB:Q15335 xref: UniProtKB:Q16363 xref: UniProtKB:Q4LE44 xref: UniProtKB:Q5SZG8 xref: UniProtKB:Q9UE18 xref: UniProtKB:Q9UJN9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004968 ! LAMA4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008017 ! lama4-rif1 physical interaction relationship: participates_in CCO:I0008018 ! lama4-tp53 physical interaction relationship: transforms_into CCO:B0012658 ! LAMA4_HUMAN-Phosphotyrosine1593 [Term] id: CCO:B0006095 name: RT12_HUMAN def: "28S ribosomal protein S12, mitochondrial precursor" [UniProtKB:O15235] synonym: "MRP-S12" EXACT [UniProtKB:O15235] synonym: "MT-RPS12" EXACT [UniProtKB:O15235] synonym: "S12mt" EXACT [UniProtKB:O15235] xref: EMBL:AAC64704.1 xref: EMBL:AAH01617.1 xref: EMBL:AAH06424.1 xref: EMBL:AAH07499.1 xref: EMBL:CAA72377.1 xref: UniProtKB:O15235 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005545 ! MRPS12_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008024 ! mrps12-rif1 physical interaction [Term] id: CCO:B0006096 name: NACA_HUMAN def: "Nascent polypeptide-associated complex subunit alpha" [UniProtKB:Q13765] synonym: "Allergen Hom s 2" EXACT [UniProtKB:Q13765] synonym: "Alpha-NAC" EXACT [UniProtKB:Q13765] synonym: "NAC-alpha" EXACT [UniProtKB:Q13765] xref: EMBL:AAC99403.1 xref: EMBL:AAI05121.1 xref: EMBL:AAI05123.1 xref: EMBL:AAI06042.1 xref: EMBL:AAK57544.1 xref: EMBL:AAV83778.1 xref: EMBL:AAX14393.1 xref: EMBL:BAD96805.1 xref: EMBL:CAA56869.1 xref: EMBL:CAG29291.1 xref: UniProtKB:Q13765 xref: UniProtKB:Q3KQV4 xref: UniProtKB:Q53A18 xref: UniProtKB:Q53G46 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005154 ! NACA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008025 ! naca-rif1 physical interaction relationship: transforms_into CCO:B0013085 ! NACA_HUMAN-Phosphoserine43 relationship: transforms_into CCO:B0013086 ! NACA_HUMAN-Phosphothreonine92 relationship: transforms_into CCO:B0013087 ! NACA_HUMAN-Phosphothreonine159 relationship: transforms_into CCO:B0013088 ! NACA_HUMAN-Phosphothreonine161 relationship: transforms_into CCO:B0013089 ! NACA_HUMAN-Phosphoserine166 relationship: transforms_into CCO:B0013090 ! NACA_HUMAN-Phosphoserine186 [Term] id: CCO:B0006097 name: PNPH_HUMAN def: "Purine nucleoside phosphorylase" [UniProtKB:P00491] synonym: "EC 2.4.2.1" EXACT [UniProtKB:P00491] synonym: "Inosine phosphorylase" EXACT [UniProtKB:P00491] synonym: "PNP" EXACT [UniProtKB:P00491] xref: EMBL:AAA36460.1 xref: EMBL:AAI04207.1 xref: EMBL:AAI04208.1 xref: EMBL:AAI06075.1 xref: EMBL:AAV68044.1 xref: EMBL:CAA25320.1 xref: EMBL:CAG28535.1 xref: UniProtKB:P00491 xref: UniProtKB:Q15160 xref: UniProtKB:Q5PZ03 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005350 ! NP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008027 ! np-rif1 physical interaction relationship: participates_in CCO:I0008138 ! np-tp53 physical interaction relationship: transforms_into CCO:B0013592 ! PNPH_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0006098 name: PA1B3_HUMAN def: "Platelet-activating factor acetylhydrolase IB subunit gamma" [UniProtKB:Q15102] synonym: "EC 3.1.1.47" EXACT [UniProtKB:Q15102] synonym: "PAF acetylhydrolase 29 kDa subunit" EXACT [UniProtKB:Q15102] synonym: "PAF-AH 29 kDa subunit" EXACT [UniProtKB:Q15102] synonym: "PAF-AH subunit gamma" EXACT [UniProtKB:Q15102] synonym: "PAFAH subunit gamma" EXACT [UniProtKB:Q15102] xref: EMBL:AAD11989.1 xref: EMBL:AAH03016.1 xref: EMBL:AAH07863.1 xref: EMBL:BAA09706.1 xref: UniProtKB:Q15102 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005251 ! PAFAH1B3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008028 ! pafah1b3-rif1 physical interaction relationship: participates_in CCO:I0008029 ! pafah1b3-tp53 physical interaction [Term] id: CCO:B0006099 name: PCDA4_HUMAN def: "Protocadherin alpha-4 precursor" [UniProtKB:Q9UN74] synonym: "PCDH-alpha-4" EXACT [UniProtKB:Q9UN74] xref: EMBL:AAC34322.1 xref: EMBL:AAD43706.1 xref: EMBL:AAD43743.1 xref: UniProtKB:O75285 xref: UniProtKB:Q9UN74 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005275 ! PCDHA4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008030 ! pcdha4-tp53 physical interaction relationship: participates_in CCO:I0008140 ! pcdha4-rif1 physical interaction [Term] id: CCO:B0006100 name: RPB3_HUMAN def: "DNA-directed RNA polymerase II subunit RPB3" [UniProtKB:P19387] synonym: "DNA-directed RNA polymerase II 33 kDa polypeptide" EXACT [UniProtKB:P19387] synonym: "DNA-directed RNA polymerase II subunit C" EXACT [UniProtKB:P19387] synonym: "RNA polymerase II subunit 3" EXACT [UniProtKB:P19387] synonym: "RNA polymerase II subunit B3" EXACT [UniProtKB:P19387] synonym: "RPB31" EXACT [UniProtKB:P19387] synonym: "RPB33" EXACT [UniProtKB:P19387] xref: EMBL:AAA36586.1 xref: EMBL:AAC14355.1 xref: EMBL:AAC24309.1 xref: EMBL:AAH00409.1 xref: EMBL:AAH03159.1 xref: EMBL:AAH28157.1 xref: EMBL:CAA11842.1 xref: EMBL:CAA11843.1 xref: UniProtKB:O15161 xref: UniProtKB:P19387 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005526 ! POLR2C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008031 ! polr2c-rif1 physical interaction [Term] id: CCO:B0006101 name: RPC6_HUMAN def: "DNA-directed RNA polymerase III subunit RPC6" [UniProtKB:Q9H1D9] synonym: "DNA-directed RNA polymerase III 39 kDa polypeptide" EXACT [UniProtKB:Q9H1D9] synonym: "DNA-directed RNA polymerase III subunit F" EXACT [UniProtKB:Q9H1D9] synonym: "RNA polymerase III subunit C6" EXACT [UniProtKB:Q9H1D9] synonym: "RPC39" EXACT [UniProtKB:Q9H1D9] xref: EMBL:AAB63677.1 xref: EMBL:AAH12588.1 xref: EMBL:CAC11110.1 xref: UniProtKB:O15319 xref: UniProtKB:Q9H1D9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005528 ! POLR3F_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008032 ! polr3f-rif1 physical interaction [Term] id: CCO:B0006102 name: IPYR_HUMAN def: "Inorganic pyrophosphatase" [UniProtKB:Q15181] synonym: "EC 3.6.1.1" EXACT [UniProtKB:Q15181] synonym: "PPase" EXACT [UniProtKB:Q15181] synonym: "Pyrophosphate phospho-hydrolase" EXACT [UniProtKB:Q15181] xref: EMBL:AAD24964.1 xref: EMBL:AAD34643.1 xref: EMBL:AAF17222.1 xref: EMBL:AAG36780.1 xref: EMBL:AAH01022.3 xref: EMBL:AAH61581.2 xref: EMBL:AAI05035.1 xref: EMBL:AAI05037.1 xref: EMBL:AAI07883.1 xref: EMBL:AAP97214.1 xref: EMBL:BAA84702.1 xref: EMBL:CAA88494.1 xref: EMBL:CAI13692.1 xref: UniProtKB:Q15181 xref: UniProtKB:Q2M348 xref: UniProtKB:Q5SQT7 xref: UniProtKB:Q6P7P4 xref: UniProtKB:Q9UQJ5 xref: UniProtKB:Q9Y5B1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004902 ! PPA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008033 ! pp-tp53 physical interaction [Term] id: CCO:B0006103 name: PSD11_HUMAN def: "26S proteasome non-ATPase regulatory subunit 11" [UniProtKB:O00231] synonym: "26S proteasome regulatory subunit p44.5" EXACT [UniProtKB:O00231] synonym: "26S proteasome regulatory subunit S9" EXACT [UniProtKB:O00231] xref: EMBL:AAB58732.1 xref: EMBL:AAH00437.1 xref: EMBL:AAH04430.1 xref: EMBL:BAA19748.1 xref: UniProtKB:O00231 xref: UniProtKB:O00495 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005388 ! PSMD11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008036 ! psmd11-rif1 physical interaction relationship: participates_in CCO:I0008037 ! psmd11-tp53 physical interaction relationship: transforms_into CCO:B0013623 ! PSD11_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013624 ! PSD11_HUMAN-Phosphoserine14 relationship: transforms_into CCO:B0013625 ! PSD11_HUMAN-Phosphoserine79 relationship: transforms_into CCO:B0013626 ! PSD11_HUMAN-Phosphoserine272 [Term] id: CCO:B0006105 name: RFC5_HUMAN def: "Replication factor C subunit 5" [UniProtKB:P40937] synonym: "A1 36 kDa subunit" EXACT [UniProtKB:P40937] synonym: "Activator 1 36 kDa subunit" EXACT [UniProtKB:P40937] synonym: "Activator 1 subunit 5" EXACT [UniProtKB:P40937] synonym: "Replication factor C 36 kDa subunit" EXACT [UniProtKB:P40937] synonym: "RF-C 36 kDa subunit" EXACT [UniProtKB:P40937] synonym: "RFC36" EXACT [UniProtKB:P40937] xref: EMBL:AAB09784.1 xref: EMBL:AAH01866.1 xref: EMBL:AAH13961.1 xref: EMBL:AAO63493.1 xref: UniProtKB:P40937 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005473 ! RFC5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008042 ! rfc5-rif1 physical interaction [Term] id: CCO:B0006107 name: SAT1_HUMAN def: "Diamine acetyltransferase 1" [UniProtKB:P21673] synonym: "EC 2.3.1.57" EXACT [UniProtKB:P21673] synonym: "Polyamine N-acetyltransferase 1" EXACT [UniProtKB:P21673] synonym: "Putrescine acetyltransferase" EXACT [UniProtKB:P21673] synonym: "Spermidine/spermine N(1)-acetyltransferase 1" EXACT [UniProtKB:P21673] synonym: "SSAT" EXACT [UniProtKB:P21673] synonym: "SSAT-1" EXACT [UniProtKB:P21673] xref: EMBL:AAA60573.1 xref: EMBL:AAA63260.1 xref: EMBL:AAA98854.1 xref: EMBL:AAH02503.1 xref: EMBL:AAH08424.1 xref: EMBL:AAP35471.1 xref: EMBL:CAA78509.1 xref: UniProtKB:P21673 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005566 ! SAT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008047 ! sat-rif1 physical interaction relationship: participates_in CCO:I0008048 ! sat-tp53 physical interaction [Term] id: CCO:B0006108 name: SPB9_HUMAN def: "Serpin B9" [UniProtKB:P50453] synonym: "CAP-3" EXACT [UniProtKB:P50453] synonym: "CAP3" EXACT [UniProtKB:P50453] synonym: "Cytoplasmic antiproteinase 3" EXACT [UniProtKB:P50453] synonym: "Proteinase inhibitor 9" EXACT [UniProtKB:P50453] xref: EMBL:AAC41940.1 xref: EMBL:AAC50793.1 xref: EMBL:AAH02538.1 xref: EMBL:AAP35319.1 xref: EMBL:BAB91078.1 xref: EMBL:CAG28555.1 xref: EMBL:CAI23290.1 xref: EMBL:EAW55093.1 xref: UniProtKB:P50453 xref: UniProtKB:Q5TD03 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005653 ! SERPINB9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008050 ! serpinb9-rif1 physical interaction relationship: participates_in CCO:I0008051 ! serpinb9-tp53 physical interaction [Term] id: CCO:B0006110 name: SMN_HUMAN def: "Survival motor neuron protein" [UniProtKB:Q16637] synonym: "Component of gems 1" EXACT [UniProtKB:Q16637] synonym: "Gemin-1" EXACT [UniProtKB:Q16637] xref: EMBL:AAA64505.1 xref: EMBL:AAA66242.1 xref: EMBL:AAC50473.1 xref: EMBL:AAC52048.1 xref: EMBL:AAC62262.1 xref: EMBL:AAC83178.1 xref: EMBL:AAH00908.1 xref: EMBL:AAH15308.1 xref: EMBL:AAH62723.1 xref: EMBL:AAH70242.1 xref: UniProtKB:Q13119 xref: UniProtKB:Q16637 xref: UniProtKB:Q549U5 xref: UniProtKB:Q96J51 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005633 ! SMN1_human relationship: encoded_by CCO:G0005634 ! SMN2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008053 ! smn1-rif1 physical interaction relationship: transforms_into CCO:B0014108 ! SMN_HUMAN-Phosphoserine4 relationship: transforms_into CCO:B0014109 ! SMN_HUMAN-Phosphoserine5 relationship: transforms_into CCO:B0014110 ! SMN_HUMAN-Phosphoserine8 relationship: transforms_into CCO:B0014111 ! SMN_HUMAN-Phosphoserine28 relationship: transforms_into CCO:B0014112 ! SMN_HUMAN-Phosphoserine31 [Term] id: CCO:B0006111 name: RSMN_HUMAN def: "Small nuclear ribonucleoprotein-associated protein N" [UniProtKB:P63162] synonym: "Sm protein N" EXACT [UniProtKB:P63162] synonym: "Sm-D" EXACT [UniProtKB:P63162] synonym: "Sm-N" EXACT [UniProtKB:P63162] synonym: "SmN" EXACT [UniProtKB:P63162] synonym: "snRNP-N" EXACT [UniProtKB:P63162] synonym: "Tissue-specific-splicing protein" EXACT [UniProtKB:P63162] xref: EMBL:AAA36617.1 xref: EMBL:AAA98969.1 xref: EMBL:AAH00611.1 xref: EMBL:AAH03180.1 xref: EMBL:AAH24777.1 xref: EMBL:AAH25178.1 xref: EMBL:AAK92481.1 xref: EMBL:CAA33901.1 xref: EMBL:CAG29346.1 xref: UniProtKB:P14648 xref: UniProtKB:P17135 xref: UniProtKB:P63162 xref: UniProtKB:Q0D2Q5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005541 ! SNRPN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008054 ! snrpn-tp53 physical interaction relationship: participates_in CCO:I0008164 ! snrpn-rif1 physical interaction [Term] id: CCO:B0006112 name: ST1E1_HUMAN def: "Estrogen sulfotransferase" [UniProtKB:P49888] synonym: "EC 2.8.2.4" EXACT [UniProtKB:P49888] synonym: "EST-1" EXACT [UniProtKB:P49888] synonym: "Sulfotransferase, estrogen-preferring" EXACT [UniProtKB:P49888] xref: EMBL:AAA82125.1 xref: EMBL:AAB34601.1 xref: EMBL:AAB51658.1 xref: EMBL:AAC50286.1 xref: EMBL:AAH27956.1 xref: EMBL:AAQ97179.1 xref: EMBL:CAA72079.1 xref: UniProtKB:P49888 xref: UniProtKB:Q8N6X5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005677 ! SULT1E1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008055 ! sult1e1-tp53 physical interaction relationship: participates_in CCO:I0008169 ! sult1e1-rif1 physical interaction [Term] id: CCO:B0006114 name: KITH_HUMAN def: "Thymidine kinase, cytosolic" [UniProtKB:P04183] synonym: "EC 2.7.1.21" EXACT [UniProtKB:P04183] xref: EMBL:AAA61187.1 xref: EMBL:AAA61189.1 xref: EMBL:AAA61191.1 xref: EMBL:AAH06484.1 xref: EMBL:AAH07872.1 xref: EMBL:AAH07986.1 xref: EMBL:AAP35587.1 xref: UniProtKB:P04183 xref: UniProtKB:Q969V0 xref: UniProtKB:Q9UMG9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004953 ! TK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008058 ! tk1-rif1 physical interaction relationship: participates_in CCO:I0008059 ! tk1-tp53 physical interaction relationship: transforms_into CCO:B0012611 ! KITH_HUMAN-Phosphoserine13 relationship: transforms_into CCO:B0012612 ! KITH_HUMAN-Phosphoserine231 [Term] id: CCO:B0006115 name: TYB4_HUMAN def: "Thymosin beta-4" [UniProtKB:P62328] synonym: "Fx" EXACT [UniProtKB:P62328] synonym: "T beta 4" EXACT [UniProtKB:P62328] xref: EMBL:AAA36745.1 xref: EMBL:AAP35753.1 xref: EMBL:CAA26323.1 xref: EMBL:CAC43317.1 xref: UniProtKB:P01253 xref: UniProtKB:P01254 xref: UniProtKB:P62328 xref: UniProtKB:Q546P5 xref: UniProtKB:Q63576 xref: UniProtKB:Q9UE55 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005850 ! TMSB4X_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008060 ! tmsb4x-tp53 physical interaction relationship: participates_in CCO:I0008175 ! tmsb4x-rif1 physical interaction relationship: transforms_into CCO:B0014557 ! TYB4_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0014558 ! TYB4_HUMAN-Phosphothreonine23 [Term] id: CCO:B0006117 name: AK1C3_HUMAN def: "Aldo-keto reductase family 1 member C3" [UniProtKB:P42330] synonym: "17-beta-HSD 5" EXACT [UniProtKB:P42330] synonym: "17-beta-hydroxysteroid dehydrogenase type 5" EXACT [UniProtKB:P42330] synonym: "3-alpha-HSD type 2" EXACT [UniProtKB:P42330] synonym: "3-alpha-HSD type II, brain" EXACT [UniProtKB:P42330] synonym: "3-alpha-hydroxysteroid dehydrogenase type 2" EXACT [UniProtKB:P42330] synonym: "Chlordecone reductase homolog HAKRb" EXACT [UniProtKB:P42330] synonym: "DD-3" EXACT [UniProtKB:P42330] synonym: "DD3" EXACT [UniProtKB:P42330] synonym: "Dihydrodiol dehydrogenase 3" EXACT [UniProtKB:P42330] synonym: "Dihydrodiol dehydrogenase type I" EXACT [UniProtKB:P42330] synonym: "EC 1.-.-.-" EXACT [UniProtKB:P42330] synonym: "EC 1.1.1.188" EXACT [UniProtKB:P42330] synonym: "EC 1.1.1.213" EXACT [UniProtKB:P42330] synonym: "EC 1.1.1.63" EXACT [UniProtKB:P42330] synonym: "EC 1.1.1.64" EXACT [UniProtKB:P42330] synonym: "EC 1.3.1.20" EXACT [UniProtKB:P42330] synonym: "HA1753" EXACT [UniProtKB:P42330] synonym: "PGFS" EXACT [UniProtKB:P42330] synonym: "Prostaglandin F synthase" EXACT [UniProtKB:P42330] synonym: "Testosterone 17-beta-dehydrogenase 5" EXACT [UniProtKB:P42330] synonym: "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase" EXACT [UniProtKB:P42330] xref: EMBL:AAB41916.1 xref: EMBL:AAD14011.1 xref: EMBL:AAF07272.2 xref: EMBL:AAH01479.1 xref: EMBL:AAH19230.1 xref: EMBL:AAP35950.1 xref: EMBL:BAA04619.2 xref: EMBL:BAA88488.1 xref: EMBL:BAA88489.1 xref: EMBL:BAA92892.1 xref: EMBL:CAI14729.1 xref: UniProtKB:P42330 xref: UniProtKB:Q5T2L1 xref: UniProtKB:Q96DJ1 xref: UniProtKB:Q96KI8 xref: UniProtKB:Q99530 xref: UniProtKB:Q9UCX1 xref: UniProtKB:Q9UII3 xref: UniProtKB:Q9UKL9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004041 ! AKR1C3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008063 ! akr1c3-rif1 physical interaction [Term] id: CCO:B0006119 name: ANXA3_HUMAN def: "Annexin A3" [UniProtKB:P12429] synonym: "35-alpha calcimedin" EXACT [UniProtKB:P12429] synonym: "Annexin III" EXACT [UniProtKB:P12429] synonym: "Annexin-3" EXACT [UniProtKB:P12429] synonym: "Inositol 1,2-cyclic phosphate 2-phosphohydrolase" EXACT [UniProtKB:P12429] synonym: "Lipocortin III" EXACT [UniProtKB:P12429] synonym: "PAP-III" EXACT [UniProtKB:P12429] synonym: "Placental anticoagulant protein III" EXACT [UniProtKB:P12429] xref: EMBL:AAA16713.1 xref: EMBL:AAA52284.1 xref: EMBL:AAA59496.1 xref: EMBL:AAH00871.1 xref: EMBL:CAG28576.1 xref: UniProtKB:P12429 xref: UniProtKB:Q6LET2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004070 ! ANXA3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008065 ! anxa3-tp53 physical interaction relationship: transforms_into CCO:B0041284 ! ANXA3_HUMAN-N-acetylalanine2 [Term] id: CCO:B0006120 name: ARL3_HUMAN def: "ADP-ribosylation factor-like protein 3" [UniProtKB:P36405] xref: EMBL:AAA21654.1 xref: EMBL:AAH09841.1 xref: EMBL:AAM12603.1 xref: UniProtKB:P36405 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004095 ! ARL3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008067 ! arl3-rif1 physical interaction relationship: participates_in CCO:I0008068 ! arl3-tp53 physical interaction [Term] id: CCO:B0006121 name: ATF3_HUMAN def: "Cyclic AMP-dependent transcription factor ATF-3" [UniProtKB:P18847] synonym: "Activating transcription factor 3" EXACT [UniProtKB:P18847] xref: EMBL:AAA20506.1 xref: EMBL:AAH06322.1 xref: EMBL:AAQ93358.1 xref: UniProtKB:P18847 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004114 ! ATF3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008069 ! atf3-tp53 physical interaction relationship: participates_in CCO:I0008192 ! atf3-rif1 physical interaction [Term] id: CCO:B0006122 name: ATPG_HUMAN def: "ATP synthase subunit gamma, mitochondrial precursor" [UniProtKB:P36542] xref: EMBL:AAH00470.1 xref: EMBL:AAH00931.1 xref: EMBL:AAH13394.1 xref: EMBL:AAH16812.1 xref: EMBL:AAH20824.1 xref: EMBL:BAA03994.1 xref: EMBL:BAA03995.1 xref: EMBL:BAA03996.1 xref: EMBL:BAA03997.1 xref: EMBL:CAH73454.1 xref: EMBL:CAI12961.1 xref: UniProtKB:P36542 xref: UniProtKB:Q5VYP3 xref: UniProtKB:Q96AS8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004121 ! ATP5C1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008194 ! atp5c1-ccnd3 physical interaction relationship: participates_in CCO:I0008360 ! atp5c1-egfr physical interaction relationship: transforms_into CCO:B0010691 ! ATPG_HUMAN-N6-acetyllysine79 relationship: transforms_into CCO:B0010692 ! ATPG_HUMAN-N6-acetyllysine90 relationship: transforms_into CCO:B0010693 ! ATPG_HUMAN-N6-acetyllysine115 [Term] id: CCO:B0006123 name: BCR_HUMAN def: "Breakpoint cluster region protein" [UniProtKB:P11274] synonym: "EC 2.7.11.1" EXACT [UniProtKB:P11274] synonym: "Renal carcinoma antigen NY-REN-26" EXACT [UniProtKB:P11274] xref: EMBL:AAA35594.1 xref: EMBL:AAB60388.1 xref: EMBL:BAE06073.1 xref: EMBL:CAA26441.1 xref: EMBL:CAA32806.1 xref: EMBL:CAA37010.1 xref: EMBL:CAA37011.1 xref: EMBL:CAA68676.1 xref: UniProtKB:P11274 xref: UniProtKB:P78501 xref: UniProtKB:Q12842 xref: UniProtKB:Q4LE80 xref: UniProtKB:Q6NZI3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004156 ! BCR_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008072 ! bcr-tp53 physical interaction relationship: transforms_into CCO:B0010778 ! BCR_HUMAN-Phosphotyrosine177 relationship: transforms_into CCO:B0010779 ! BCR_HUMAN-Phosphothreonine310 relationship: transforms_into CCO:B0010780 ! BCR_HUMAN-Phosphoserine459 relationship: transforms_into CCO:B0010781 ! BCR_HUMAN-Phosphoserine463 relationship: transforms_into CCO:B0010782 ! BCR_HUMAN-Phosphotyrosine591 relationship: transforms_into CCO:B0010783 ! BCR_HUMAN-Phosphotyrosine644 relationship: transforms_into CCO:B0010784 ! BCR_HUMAN-Phosphoserine1264 relationship: transforms_into CCO:B0031297 ! BCR_HUMAN-Phosphoserine236 relationship: transforms_into CCO:B0031298 ! BCR_HUMAN-Phosphotyrosine246 [Term] id: CCO:B0006124 name: Q5T8Z1_HUMAN def: "BMI1 polycomb ring finger oncogene" [UniProtKB:Q5T8Z1] xref: EMBL:CAI15957.1 xref: UniProtKB:Q5T8Z1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005999 ! BMI1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008073 ! bmi1-rif1 physical interaction [Term] id: CCO:B0006126 name: CBX1_HUMAN def: "Chromobox protein homolog 1" [UniProtKB:P83916] synonym: "Heterochromatin protein 1 homolog beta" EXACT [UniProtKB:P83916] synonym: "Heterochromatin protein p25" EXACT [UniProtKB:P83916] synonym: "HP1 beta" EXACT [UniProtKB:P83916] synonym: "HP1Hsbeta" EXACT [UniProtKB:P83916] synonym: "M31" EXACT [UniProtKB:P83916] synonym: "Modifier 1 protein" EXACT [UniProtKB:P83916] synonym: "p25beta" EXACT [UniProtKB:P83916] xref: EMBL:AAB81548.1 xref: EMBL:AAH02609.1 xref: EMBL:AAH21302.1 xref: UniProtKB:P23197 xref: UniProtKB:P83916 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004231 ! CBX1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008075 ! cbx1-rif1 physical interaction relationship: transforms_into CCO:B0010965 ! CBX1_HUMAN-Phosphoserine89 relationship: transforms_into CCO:B0010966 ! CBX1_HUMAN-Phosphoserine175 [Term] id: CCO:B0006127 name: BAT3_HUMAN def: "Large proline-rich protein BAT3" [UniProtKB:P46379] synonym: "HLA-B-associated transcript 3" EXACT [UniProtKB:P46379] synonym: "Protein G3" EXACT [UniProtKB:P46379] xref: EMBL:AAA35587.1 xref: EMBL:AAA35588.1 xref: EMBL:AAD18085.1 xref: EMBL:AAH03133.1 xref: EMBL:BAB63390.1 xref: EMBL:CAI17658.1 xref: EMBL:CAI17659.1 xref: EMBL:CAI17784.1 xref: EMBL:CAI17785.1 xref: EMBL:CAI17786.1 xref: EMBL:CAI18314.1 xref: EMBL:CAI18315.1 xref: EMBL:CAI18316.2 xref: EMBL:CAI18318.2 xref: EMBL:CAI18501.1 xref: EMBL:CAI18504.1 xref: EMBL:CAI18508.2 xref: EMBL:CAI18509.1 xref: EMBL:CAI46045.1 xref: EMBL:CAM25014.1 xref: EMBL:CAM45799.1 xref: EMBL:CAM45800.1 xref: EMBL:CAM45801.1 xref: EMBL:CAO72072.1 xref: UniProtKB:A2ADJ7 xref: UniProtKB:A3KQ42 xref: UniProtKB:A3KQ44 xref: UniProtKB:A6NGY6 xref: UniProtKB:A6PWF7 xref: UniProtKB:O95874 xref: UniProtKB:P46379 xref: UniProtKB:Q5HYL9 xref: UniProtKB:Q5SQ35 xref: UniProtKB:Q5SQ36 xref: UniProtKB:Q5SQ37 xref: UniProtKB:Q5SQ41 xref: UniProtKB:Q5SRP8 xref: UniProtKB:Q5SRP9 xref: UniProtKB:Q5STC1 xref: UniProtKB:Q5STX1 xref: UniProtKB:Q5STX3 xref: UniProtKB:Q96SA6 xref: UniProtKB:Q9BCN4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004140 ! BAT3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008079 ! cdk4-bat3 physical interaction relationship: transforms_into CCO:B0010747 ! BAT3_HUMAN-Phosphoserine113 relationship: transforms_into CCO:B0010748 ! BAT3_HUMAN-Phosphoserine964 relationship: transforms_into CCO:B0010749 ! BAT3_HUMAN-Phosphoserine973 relationship: transforms_into CCO:B0010750 ! BAT3_HUMAN-Phosphoserine1039 relationship: transforms_into CCO:B0010751 ! BAT3_HUMAN-Phosphotyrosine1042 relationship: transforms_into CCO:B0010752 ! BAT3_HUMAN-Phosphoserine1117 [Term] id: CCO:B0006130 name: PDE6D_HUMAN def: "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta" [UniProtKB:O43924] synonym: "EC 3.1.4.17" EXACT [UniProtKB:O43924] synonym: "GMP-PDE delta" EXACT [UniProtKB:O43924] synonym: "p17 protein" EXACT [UniProtKB:O43924] xref: EMBL:AAB87872.1 xref: EMBL:AAC25953.1 xref: EMBL:AAC39720.1 xref: EMBL:AAH07831.1 xref: EMBL:AAP35942.1 xref: EMBL:CAA04880.1 xref: UniProtKB:O43250 xref: UniProtKB:O43924 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005286 ! PDE6D_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008085 ! cetn3-pde6d physical interaction [Term] id: CCO:B0006131 name: KCRS_HUMAN def: "Creatine kinase, sarcomeric mitochondrial precursor" [UniProtKB:P17540] synonym: "Basic-type mitochondrial creatine kinase" EXACT [UniProtKB:P17540] synonym: "EC 2.7.3.2" EXACT [UniProtKB:P17540] synonym: "Mib-CK" EXACT [UniProtKB:P17540] synonym: "S-MtCK" EXACT [UniProtKB:P17540] xref: EMBL:AAA60561.1 xref: EMBL:AAH29140.1 xref: EMBL:CAG29311.1 xref: UniProtKB:P17540 xref: UniProtKB:Q6ICS8 xref: UniProtKB:Q8N1E1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004935 ! CKMT2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008088 ! ckmt2-rif1 physical interaction [Term] id: CCO:B0006133 name: CSN6_HUMAN def: "COP9 signalosome complex subunit 6" [UniProtKB:Q7L5N1] synonym: "hVIP" EXACT [UniProtKB:Q7L5N1] synonym: "JAB1-containing signalosome subunit 6" EXACT [UniProtKB:Q7L5N1] synonym: "MOV34 homolog" EXACT [UniProtKB:Q7L5N1] synonym: "SGN6" EXACT [UniProtKB:Q7L5N1] synonym: "Signalosome subunit 6" EXACT [UniProtKB:Q7L5N1] synonym: "Vpr-interacting protein" EXACT [UniProtKB:Q7L5N1] xref: EMBL:AAD03469.1 xref: EMBL:AAH02520.2 xref: UniProtKB:O15387 xref: UniProtKB:Q7L5N1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004409 ! COPS6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008093 ! dleu1-cops6 physical interaction relationship: participates_in CCO:I0008149 ! pmf1-cops6 physical interaction relationship: participates_in CCO:I0008214 ! cdkn2c-cops6 physical interaction relationship: participates_in CCO:I0008227 ! ep300-cops6 physical interaction relationship: participates_in CCO:I0008236 ! smpd3-cops6 physical interaction relationship: participates_in CCO:I0008268 ! mnat1-cops6 physical interaction relationship: participates_in CCO:I0008303 ! pten-cops6 physical interaction [Term] id: CCO:B0006134 name: UT14A_HUMAN def: "U3 small nucleolar RNA-associated protein 14 homolog A" [UniProtKB:Q9BVJ6] synonym: "Antigen NY-CO-16" EXACT [UniProtKB:Q9BVJ6] synonym: "Serologically defined colon cancer antigen 16" EXACT [UniProtKB:Q9BVJ6] xref: EMBL:AAH01149.1 xref: EMBL:AAH09649.1 xref: EMBL:AAH14987.1 xref: EMBL:CAI42908.1 xref: EMBL:CAI42909.1 xref: UniProtKB:Q5JYF1 xref: UniProtKB:Q9BVJ6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005889 ! UTP14A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008096 ! dleu1-utp14a physical interaction relationship: participates_in CCO:I0008181 ! tp53bp2-utp14a physical interaction relationship: participates_in CCO:I0008199 ! axin1-utp14a physical interaction relationship: participates_in CCO:I0008337 ! terf1-utp14a physical interaction relationship: participates_in CCO:I0008422 ! pten-utp14a physical interaction relationship: transforms_into CCO:B0014585 ! UT14A_HUMAN-Phosphoserine29 relationship: transforms_into CCO:B0014586 ! UT14A_HUMAN-Phosphoserine31 relationship: transforms_into CCO:B0014587 ! UT14A_HUMAN-Phosphoserine434 relationship: transforms_into CCO:B0014588 ! UT14A_HUMAN-Phosphoserine437 relationship: transforms_into CCO:B0014589 ! UT14A_HUMAN-Phosphoserine445 relationship: transforms_into CCO:B0014590 ! UT14A_HUMAN-Phosphoserine451 relationship: transforms_into CCO:B0014591 ! UT14A_HUMAN-Phosphoserine453 [Term] id: CCO:B0006135 name: UBR1_HUMAN def: "E3 ubiquitin-protein ligase UBR1" [UniProtKB:Q8IWV7] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q8IWV7] synonym: "N-recognin-1" EXACT [UniProtKB:Q8IWV7] synonym: "Ubiquitin-protein ligase E3-alpha-1" EXACT [UniProtKB:Q8IWV7] synonym: "Ubiquitin-protein ligase E3-alpha-I" EXACT [UniProtKB:Q8IWV7] xref: EMBL:AAC23677.1 xref: EMBL:AAC39845.1 xref: EMBL:AAI13506.1 xref: EMBL:AAI13508.1 xref: EMBL:AAL32103.1 xref: EMBL:AAO14997.1 xref: EMBL:BAB55380.1 xref: EMBL:CAH18181.1 xref: UniProtKB:O60708 xref: UniProtKB:O75492 xref: UniProtKB:Q14D45 xref: UniProtKB:Q68DN9 xref: UniProtKB:Q8IWV7 xref: UniProtKB:Q8IWY6 xref: UniProtKB:Q96JY4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005874 ! UBR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008098 ! dleu1-ubr1 physical interaction relationship: transforms_into CCO:B0014572 ! UBR1_HUMAN-Phosphothreonine21 relationship: transforms_into CCO:B0014573 ! UBR1_HUMAN-Phosphoserine1179 [Term] id: CCO:B0006137 name: DNJB9_HUMAN def: "DnaJ homolog subfamily B member 9" [UniProtKB:Q9UBS3] synonym: "Mdg-1" EXACT [UniProtKB:Q9UBS3] synonym: "Microvascular endothelial differentiation gene 1 protein" EXACT [UniProtKB:Q9UBS3] xref: EMBL:AAD39845.1 xref: EMBL:AAH28912.1 xref: EMBL:AAQ89404.1 xref: EMBL:BAA84703.1 xref: EMBL:CAB45701.1 xref: UniProtKB:Q9UBS3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004491 ! DNAJB9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008100 ! dnajb9-plk1 physical interaction [Term] id: CCO:B0006138 name: TRDMT_HUMAN def: "tRNA (cytosine-5-)-methyltransferase" [UniProtKB:O14717] synonym: "DNA (cytosine-5)-methyltransferase-like protein 2" EXACT [UniProtKB:O14717] synonym: "DNA methyltransferase homolog HsaIIP" EXACT [UniProtKB:O14717] synonym: "DNA MTase homolog HsaIIP" EXACT [UniProtKB:O14717] synonym: "Dnmt2" EXACT [UniProtKB:O14717] synonym: "EC 2.1.1.29" EXACT [UniProtKB:O14717] synonym: "M.HsaIIP" EXACT [UniProtKB:O14717] synonym: "PuMet" EXACT [UniProtKB:O14717] xref: EMBL:AAC39764.1 xref: EMBL:AAC51939.1 xref: EMBL:AAK68033.1 xref: EMBL:AAK68034.1 xref: EMBL:AAK68035.1 xref: EMBL:AAK68036.1 xref: EMBL:AAK68037.1 xref: EMBL:CAA11272.1 xref: EMBL:CAB87964.1 xref: UniProtKB:O14717 xref: UniProtKB:O43669 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005826 ! TRDMT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008101 ! dnmt2-rif1 physical interaction [Term] id: CCO:B0006140 name: FXR1_HUMAN def: "Fragile X mental retardation syndrome-related protein 1" [UniProtKB:P51114] synonym: "hFXR1p" EXACT [UniProtKB:P51114] xref: EMBL:AAC50155.1 xref: EMBL:AAH28983.1 xref: EMBL:AAQ20045.1 xref: UniProtKB:P51114 xref: UniProtKB:Q7Z450 xref: UniProtKB:Q8N6R8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004664 ! FXR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008107 ! fxr1-rif1 physical interaction relationship: transforms_into CCO:B0011903 ! FXR1_HUMAN-Phosphoserine406 relationship: transforms_into CCO:B0011904 ! FXR1_HUMAN-Phosphoserine409 relationship: transforms_into CCO:B0011905 ! FXR1_HUMAN-Omega-N-methylated arginine445 relationship: transforms_into CCO:B0011906 ! FXR1_HUMAN-Phosphotyrosine477 relationship: transforms_into CCO:B0031320 ! FXR1_HUMAN-Phosphotyrosine68 [Term] id: CCO:B0006141 name: FXYD6_HUMAN def: "FXYD domain-containing ion transport regulator 6 precursor" [UniProtKB:Q9H0Q3] xref: EMBL:AAH18652.1 xref: EMBL:AAH93040.1 xref: EMBL:AAP35363.1 xref: EMBL:AAQ89335.1 xref: EMBL:CAB66634.1 xref: EMBL:CAG38488.1 xref: EMBL:CAI46171.1 xref: UniProtKB:Q6FIG9 xref: UniProtKB:Q6UW52 xref: UniProtKB:Q9H0Q3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004665 ! FXYD6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008108 ! fxyd6-tp53 physical interaction [Term] id: CCO:B0006142 name: GBB5_HUMAN def: "Guanine nucleotide-binding protein subunit beta-5" [UniProtKB:O14775] synonym: "Gbeta5" EXACT [UniProtKB:O14775] synonym: "Transducin beta chain 5" EXACT [UniProtKB:O14775] xref: EMBL:AAC63826.1 xref: EMBL:AAG18444.1 xref: EMBL:AAH13997.1 xref: EMBL:AAM15921.1 xref: UniProtKB:O14775 xref: UniProtKB:Q9HAU9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004686 ! GNB5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008109 ! gnb5-mcm2 physical interaction [Term] id: CCO:B0006144 name: GSTM4_HUMAN def: "Glutathione S-transferase Mu 4" [UniProtKB:Q03013] synonym: "EC 2.5.1.18" EXACT [UniProtKB:Q03013] synonym: "GST class-mu 4" EXACT [UniProtKB:Q03013] synonym: "GSTM4-4" EXACT [UniProtKB:Q03013] synonym: "GTS-Mu2" EXACT [UniProtKB:Q03013] xref: EMBL:AAA57346.1 xref: EMBL:AAA57347.1 xref: EMBL:AAA58623.1 xref: EMBL:AAH15513.1 xref: EMBL:AAI08730.1 xref: EMBL:CAA40167.1 xref: EMBL:CAA48637.1 xref: EMBL:CAG46667.1 xref: UniProtKB:Q03013 xref: UniProtKB:Q05465 xref: UniProtKB:Q32NC1 xref: UniProtKB:Q6FH87 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004736 ! GSTM4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008113 ! gstm4-rif1 physical interaction relationship: participates_in CCO:I0008114 ! gstm4-tp53 physical interaction [Term] id: CCO:B0006147 name: HA23_HUMAN def: "HLA class II histocompatibility antigen, DQ(3) alpha chain precursor" [UniProtKB:P01909] synonym: "DC-alpha" EXACT [UniProtKB:P01909] synonym: "HLA-DCA" EXACT [UniProtKB:P01909] synonym: "HLA-DQA1*05011" EXACT [UniProtKB:P01909] synonym: "HLA-DQA1*0502" EXACT [UniProtKB:P01909] xref: EMBL:AAA35772.1 xref: EMBL:AAA59774.1 xref: EMBL:AAB60341.1 xref: EMBL:AAB91990.1 xref: EMBL:AAH08585.1 xref: EMBL:CAB06491.1 xref: UniProtKB:O19630 xref: UniProtKB:P01909 xref: UniProtKB:Q30101 xref: UniProtKB:Q9UM31 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004776 ! HLA-DQA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008117 ! hla_dqa1-rif1 physical interaction [Term] id: CCO:B0006148 name: HMOX2_HUMAN def: "Heme oxygenase 2" [UniProtKB:P30519] synonym: "EC 1.14.99.3" EXACT [UniProtKB:P30519] synonym: "HO-2" EXACT [UniProtKB:P30519] xref: EMBL:AAB22110.2 xref: EMBL:AAC05297.1 xref: EMBL:AAH02396.1 xref: EMBL:AAV28730.1 xref: EMBL:AAV38591.1 xref: EMBL:BAA04789.1 xref: UniProtKB:O60605 xref: UniProtKB:P30519 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004813 ! HMOX2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008120 ! hmox2-rif1 physical interaction [Term] id: CCO:B0006149 name: ID2_HUMAN def: "DNA-binding protein inhibitor ID-2" [UniProtKB:Q02363] synonym: "Inhibitor of DNA binding 2" EXACT [UniProtKB:Q02363] xref: EMBL:AAA58681.1 xref: EMBL:AAH30639.1 xref: EMBL:BAA02990.1 xref: UniProtKB:Q02363 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004848 ! ID2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008125 ! id2-rif1 physical interaction [Term] id: CCO:B0006150 name: LC7L2_HUMAN def: "Putative RNA-binding protein Luc7-like 2" [UniProtKB:Q9Y383] xref: EMBL:AAD34054.1 xref: EMBL:AAD34069.1 xref: EMBL:AAH17163.1 xref: EMBL:AAH42625.1 xref: EMBL:AAH50708.1 xref: EMBL:AAH56886.1 xref: EMBL:BAA91713.1 xref: EMBL:BAA91737.1 xref: EMBL:BAB14297.1 xref: UniProtKB:Q8IUP9 xref: UniProtKB:Q9NVL3 xref: UniProtKB:Q9NVN7 xref: UniProtKB:Q9UQN1 xref: UniProtKB:Q9Y383 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004973 ! LUC7L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008279 ! nasp-luc7l2 physical interaction relationship: transforms_into CCO:B0012683 ! LC7L2_HUMAN-Phosphothreonine17 relationship: transforms_into CCO:B0012684 ! LC7L2_HUMAN-Phosphoserine18 relationship: transforms_into CCO:B0012685 ! LC7L2_HUMAN-Phosphothreonine111 relationship: transforms_into CCO:B0012686 ! LC7L2_HUMAN-Phosphoserine354 relationship: transforms_into CCO:B0012687 ! LC7L2_HUMAN-Phosphoserine358 relationship: transforms_into CCO:B0012688 ! LC7L2_HUMAN-Phosphoserine383 relationship: transforms_into CCO:B0012689 ! LC7L2_HUMAN-Phosphoserine384 [Term] id: CCO:B0006152 name: PDCD5_HUMAN def: "Programmed cell death protein 5" [UniProtKB:O14737] synonym: "Protein TFAR19" EXACT [UniProtKB:O14737] synonym: "TF-1 cell apoptosis-related protein 19" EXACT [UniProtKB:O14737] xref: EMBL:AAD11579.1 xref: EMBL:AAH15519.1 xref: EMBL:AAP35340.1 xref: EMBL:CAG33215.1 xref: UniProtKB:O14737 xref: UniProtKB:Q53YC9 xref: UniProtKB:Q6IB70 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005285 ! PDCD5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008141 ! pdcd5-rif1 physical interaction relationship: transforms_into CCO:B0013454 ! PDCD5_HUMAN-Phosphoserine119 [Term] id: CCO:B0006153 name: HAP1_HUMAN def: "Huntingtin-associated protein 1" [UniProtKB:P54257] synonym: "HAP-1" EXACT [UniProtKB:P54257] synonym: "Neuroan 1" EXACT [UniProtKB:P54257] xref: EMBL:AAC39861.1 xref: EMBL:AAC50297.1 xref: EMBL:BAB13952.1 xref: EMBL:CAB82785.1 xref: EMBL:CAC09418.1 xref: UniProtKB:O75358 xref: UniProtKB:P54257 xref: UniProtKB:Q9H4G3 xref: UniProtKB:Q9HA98 xref: UniProtKB:Q9NY90 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004777 ! HAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008144 ! pfdn1-hap1 physical interaction [Term] id: CCO:B0006154 name: PROF1_HUMAN def: "Profilin-1" [UniProtKB:P07737] synonym: "Profilin I" EXACT [UniProtKB:P07737] xref: EMBL:AAA36486.1 xref: EMBL:AAH02475.1 xref: EMBL:AAH06768.1 xref: EMBL:AAH13439.1 xref: EMBL:AAH15164.1 xref: EMBL:AAH57828.1 xref: UniProtKB:P07737 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005380 ! PFN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008148 ! pfn1-rif1 physical interaction relationship: transforms_into CCO:B0013613 ! PROF1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013614 ! PROF1_HUMAN-N6-acetyllysine105 relationship: transforms_into CCO:B0013615 ! PROF1_HUMAN-Phosphotyrosine129 [Term] id: CCO:B0006155 name: PROF2_HUMAN def: "Profilin-2" [UniProtKB:P35080] synonym: "Profilin II" EXACT [UniProtKB:P35080] xref: EMBL:AAA03022.1 xref: EMBL:AAG24949.1 xref: EMBL:AAH18049.1 xref: EMBL:AAH43646.1 xref: UniProtKB:P35080 xref: UniProtKB:Q8WVF9 xref: UniProtKB:Q9HBK2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005381 ! PFN2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008151 ! sept5-pfn2 physical interaction relationship: participates_in CCO:I0008173 ! terf1-pfn2 physical interaction relationship: transforms_into CCO:B0013616 ! PROF2_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0031368 ! PROF2_HUMAN-Phosphotyrosine99 [Term] id: CCO:B0006157 name: PSG9_HUMAN def: "Pregnancy-specific beta-1-glycoprotein 9 precursor" [UniProtKB:Q00887] synonym: "Pregnancy-specific beta-1 glycoprotein B" EXACT [UniProtKB:Q00887] synonym: "Pregnancy-specific glycoprotein 7" EXACT [UniProtKB:Q00887] synonym: "Pregnancy-specific glycoprotein 9" EXACT [UniProtKB:Q00887] synonym: "PS-beta-B" EXACT [UniProtKB:Q00887] synonym: "PS34" EXACT [UniProtKB:Q00887] synonym: "PSBG-9" EXACT [UniProtKB:Q00887] synonym: "PSG7" EXACT [UniProtKB:Q00887] xref: EMBL:AAA52605.1 xref: EMBL:AAA60203.1 xref: EMBL:AAA63251.1 xref: EMBL:AAA63252.1 xref: EMBL:AAA74512.1 xref: EMBL:AAA78266.1 xref: EMBL:AAD21023.1 xref: EMBL:AAH20759.1 xref: EMBL:CAA35612.1 xref: UniProtKB:Q00887 xref: UniProtKB:Q15236 xref: UniProtKB:Q15237 xref: UniProtKB:Q8WW78 xref: UniProtKB:Q9UQ73 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005389 ! PSG9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008154 ! psg9-rif1 physical interaction [Term] id: CCO:B0006158 name: DDR1_HUMAN def: "Epithelial discoidin domain-containing receptor 1 precursor" [UniProtKB:Q08345] synonym: "CD167a antigen" EXACT [UniProtKB:Q08345] synonym: "Cell adhesion kinase" EXACT [UniProtKB:Q08345] synonym: "Discoidin receptor tyrosine kinase" EXACT [UniProtKB:Q08345] synonym: "EC 2.7.10.1" EXACT [UniProtKB:Q08345] synonym: "Epithelial discoidin domain receptor 1" EXACT [UniProtKB:Q08345] synonym: "HGK2" EXACT [UniProtKB:Q08345] synonym: "Protein-tyrosine kinase RTK 6" EXACT [UniProtKB:Q08345] synonym: "TRK E" EXACT [UniProtKB:Q08345] synonym: "Tyrosine kinase DDR" EXACT [UniProtKB:Q08345] synonym: "Tyrosine-protein kinase CAK" EXACT [UniProtKB:Q08345] xref: EMBL:AAA02866.1 xref: EMBL:AAA18019.1 xref: EMBL:AAB05208.1 xref: EMBL:AAC50917.1 xref: EMBL:AAH08716.1 xref: EMBL:AAH13400.1 xref: EMBL:BAB63318.1 xref: EMBL:CAA52915.1 xref: EMBL:CAA66871.1 xref: EMBL:CAA82335.1 xref: EMBL:CAI17434.1 xref: EMBL:CAI18441.1 xref: EMBL:CAI18450.1 xref: EMBL:CAI18534.1 xref: UniProtKB:Q08345 xref: UniProtKB:Q14196 xref: UniProtKB:Q16562 xref: UniProtKB:Q5ST12 xref: UniProtKB:Q9UD37 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004453 ! DDR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008157 ! rgs2-ddr1 physical interaction relationship: transforms_into CCO:B0011459 ! DDR1_HUMAN-Phosphotyrosine513 relationship: transforms_into CCO:B0011460 ! DDR1_HUMAN-Phosphotyrosine792 relationship: transforms_into CCO:B0011461 ! DDR1_HUMAN-Phosphotyrosine796 relationship: transforms_into CCO:B0011462 ! DDR1_HUMAN-Phosphotyrosine797 [Term] id: CCO:B0006159 name: S10A8_HUMAN def: "Protein S100-A8" [UniProtKB:P05109] synonym: "Calgranulin-A" EXACT [UniProtKB:P05109] synonym: "Calprotectin L1L subunit" EXACT [UniProtKB:P05109] synonym: "CFAG" EXACT [UniProtKB:P05109] synonym: "Cystic fibrosis antigen" EXACT [UniProtKB:P05109] synonym: "Leukocyte L1 complex light chain" EXACT [UniProtKB:P05109] synonym: "Migration inhibitory factor-related protein 8" EXACT [UniProtKB:P05109] synonym: "MRP-8" EXACT [UniProtKB:P05109] synonym: "P8" EXACT [UniProtKB:P05109] synonym: "S100 calcium-binding protein A8" EXACT [UniProtKB:P05109] synonym: "Urinary stone protein band A" EXACT [UniProtKB:P05109] xref: EMBL:AAA36327.1 xref: EMBL:AAH05928.1 xref: EMBL:AAP36042.1 xref: EMBL:CAA29580.1 xref: EMBL:CAA68390.1 xref: EMBL:CAG28602.1 xref: EMBL:CAI19497.1 xref: UniProtKB:P05109 xref: UniProtKB:Q5SY70 xref: UniProtKB:Q9UC92 xref: UniProtKB:Q9UCJ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005553 ! S100A8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008159 ! s100a8-rif1 physical interaction relationship: participates_in CCO:I0008319 ! s100a8-tp53 physical interaction [Term] id: CCO:B0006162 name: SOCS3_HUMAN def: "Suppressor of cytokine signaling 3" [UniProtKB:O14543] synonym: "CIS-3" EXACT [UniProtKB:O14543] synonym: "Cytokine-inducible SH2 protein 3" EXACT [UniProtKB:O14543] synonym: "SOCS-3" EXACT [UniProtKB:O14543] synonym: "SSI-3" EXACT [UniProtKB:O14543] synonym: "STAT-induced STAT inhibitor 3" EXACT [UniProtKB:O14543] xref: EMBL:AAD42231.1 xref: EMBL:AAH60858.1 xref: EMBL:BAA22430.1 xref: EMBL:BAA22537.1 xref: UniProtKB:O14509 xref: UniProtKB:O14543 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005648 ! SOCS3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008165 ! socs3-pin1 physical interaction [Term] id: CCO:B0006164 name: STX5_HUMAN def: "Syntaxin-5" [UniProtKB:Q13190] xref: EMBL:AAC71078.1 xref: EMBL:AAH02645.1 xref: EMBL:AAH12137.2 xref: EMBL:AAV38452.1 xref: EMBL:AAV38453.1 xref: EMBL:CAD97668.1 xref: UniProtKB:Q13190 xref: UniProtKB:Q5U0D4 xref: UniProtKB:Q7Z3T6 xref: UniProtKB:Q9BUG1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005701 ! STX5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008168 ! stx5a-tp53 physical interaction relationship: participates_in CCO:I0008326 ! stx5a-rif1 physical interaction [Term] id: CCO:B0006165 name: Q52MB0_HUMAN def: "Tumor protein p53-activated protein 1" [UniProtKB:Q52MB0] xref: EMBL:AAH61927.1 xref: UniProtKB:Q52MB0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005991 ! TP53AP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008177 ! tp53ap1-tp53 physical interaction [Term] id: CCO:B0006166 name: KIF5A_HUMAN def: "Kinesin heavy chain isoform 5A" [UniProtKB:Q12840] synonym: "Kinesin heavy chain neuron-specific 1" EXACT [UniProtKB:Q12840] synonym: "Neuronal kinesin heavy chain" EXACT [UniProtKB:Q12840] synonym: "NKHC" EXACT [UniProtKB:Q12840] xref: EMBL:AAA20231.1 xref: EMBL:BAE06127.1 xref: UniProtKB:Q12840 xref: UniProtKB:Q4LE26 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004950 ! KIF5A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008179 ! tp53bp2-kif5a physical interaction [Term] id: CCO:B0006167 name: TBB4_HUMAN def: "Tubulin beta-4 chain" [UniProtKB:P04350] synonym: "Tubulin 5 beta" EXACT [UniProtKB:P04350] xref: EMBL:AAH06570.1 xref: EMBL:AAH13683.1 xref: EMBL:CAA25318.1 xref: UniProtKB:P04350 xref: UniProtKB:Q969E5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005736 ! TUBB4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008183 ! tubb4-khdrbs1 physical interaction relationship: participates_in CCO:I0008513 ! tubb4-lig1 physical interaction relationship: transforms_into CCO:B0014315 ! TBB4_HUMAN-Phosphothreonine290 relationship: transforms_into CCO:B0014316 ! TBB4_HUMAN-Phosphothreonine366 relationship: transforms_into CCO:B0031379 ! TBB4_HUMAN-Phosphotyrosine36 [Term] id: CCO:B0006168 name: IGS21_HUMAN def: "Immunoglobulin superfamily member 21 precursor" [UniProtKB:Q96ID5] xref: EMBL:AAH07618.1 xref: EMBL:BAC11542.1 xref: EMBL:CAH70256.1 xref: EMBL:CAH70900.1 xref: EMBL:CAH71695.1 xref: EMBL:CAI22205.1 xref: UniProtKB:Q8NBR8 xref: UniProtKB:Q96ID5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004870 ! IGSF21_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008261 ! mad2l1bp-igsf21 physical interaction [Term] id: CCO:B0006169 name: WDR33_HUMAN def: "WD repeat-containing protein 33" [UniProtKB:Q9C0J8] synonym: "WD repeat-containing protein WDC146" EXACT [UniProtKB:Q9C0J8] xref: EMBL:BAB32435.1 xref: UniProtKB:Q9C0J8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005918 ! WDR33_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008187 ! wdr33-tp53 physical interaction relationship: transforms_into CCO:B0014674 ! WDR33_HUMAN-Phosphoserine7 [Term] id: CCO:B0006170 name: Q5ZF45_HUMAN def: "KLEIP" [UniProtKB:Q5ZF45] synonym: "Kelch-like ECT2 interacting protein" EXACT [UniProtKB:Q5ZF45] xref: EMBL:CAH59617.1 xref: UniProtKB:Q5ZF45 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006004 ! KLHLX_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008188 ! klhlx-rif1 physical interaction relationship: participates_in CCO:I0008353 ! klhlx-pin1 physical interaction [Term] id: CCO:B0006171 name: Q6ICP4_HUMAN def: "ARHH protein" [UniProtKB:Q6ICP4] synonym: "Ras homolog gene family, member H, isoform CRA_a" EXACT [UniProtKB:Q6ICP4] xref: EMBL:CAG29345.1 xref: EMBL:EAW92960.1 xref: UniProtKB:Q6ICP4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006008 ! ARHH_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008189 ! arhh-rif1 physical interaction [Term] id: CCO:B0006172 name: ARPC3_HUMAN def: "Actin-related protein 2/3 complex subunit 3" [UniProtKB:O15145] synonym: "Arp2/3 complex 21 kDa subunit" EXACT [UniProtKB:O15145] synonym: "p21-ARC" EXACT [UniProtKB:O15145] xref: EMBL:AAB61466.1 xref: EMBL:AAB64191.1 xref: EMBL:AAH67747.1 xref: EMBL:AAH78162.1 xref: EMBL:CAG28595.1 xref: UniProtKB:O00554 xref: UniProtKB:O15145 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004102 ! ARPC3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008191 ! arpc3-cdkn2b physical interaction relationship: participates_in CCO:I0008358 ! arpc3-centd2 physical interaction relationship: transforms_into CCO:B0031294 ! ARPC3_HUMAN-Phosphotyrosine47 [Term] id: CCO:B0006173 name: WDR62_HUMAN def: "WD repeat-containing protein 62" [UniProtKB:O43379] xref: EMBL:AAC27979.1 xref: EMBL:AAH17261.1 xref: EMBL:BAC03488.1 xref: EMBL:CAH56191.1 xref: EMBL:CAH56390.1 xref: UniProtKB:O43379 xref: UniProtKB:Q63HP9 xref: UniProtKB:Q659D7 xref: UniProtKB:Q8NBF7 xref: UniProtKB:Q96AD9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005925 ! WDR62_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008205 ! c19orf14-rif1 physical interaction relationship: transforms_into CCO:B0014677 ! WDR62_HUMAN-Phosphoserine33 relationship: transforms_into CCO:B0014678 ! WDR62_HUMAN-Phosphoserine987 relationship: transforms_into CCO:B0014679 ! WDR62_HUMAN-Phosphoserine992 relationship: transforms_into CCO:B0014680 ! WDR62_HUMAN-Phosphoserine995 relationship: transforms_into CCO:B0014681 ! WDR62_HUMAN-Phosphothreonine1053 relationship: transforms_into CCO:B0014682 ! WDR62_HUMAN-Phosphoserine1070 relationship: transforms_into CCO:B0014683 ! WDR62_HUMAN-Phosphoserine1093 relationship: transforms_into CCO:B0014684 ! WDR62_HUMAN-Phosphoserine1101 relationship: transforms_into CCO:B0014685 ! WDR62_HUMAN-Phosphoserine1228 relationship: transforms_into CCO:B0014686 ! WDR62_HUMAN-Phosphoserine1348 relationship: transforms_into CCO:B0014687 ! WDR62_HUMAN-Phosphoserine1405 [Term] id: CCO:B0006174 name: CG020_HUMAN def: "UPF0363 protein C7orf20" [UniProtKB:Q7L5D6] xref: EMBL:AAD27729.1 xref: EMBL:AAH03550.2 xref: EMBL:CAB61355.1 xref: UniProtKB:Q7L5D6 xref: UniProtKB:Q9UFC9 xref: UniProtKB:Q9Y309 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004336 ! C7orf20_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008207 ! c7orf20-plk1 physical interaction relationship: participates_in CCO:I0008365 ! c7orf20-cdkn1a physical interaction relationship: transforms_into CCO:B0041286 ! CG020_HUMAN-N-acetylalanine2 [Term] id: CCO:B0006179 name: APLP1_HUMAN def: "Amyloid-like protein 1 precursor" [UniProtKB:P51693] synonym: "APLP" EXACT [UniProtKB:P51693] synonym: "APLP-1" EXACT [UniProtKB:P51693] xref: EMBL:AAB50173.1 xref: EMBL:AAB96331.1 xref: EMBL:AAH12889.1 xref: UniProtKB:O00113 xref: UniProtKB:P51693 xref: UniProtKB:Q96A92 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004082 ! APLP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008213 ! cdkn2c-aplp1 physical interaction relationship: participates_in CCO:I0008272 ! mphosph6-aplp1 physical interaction [Term] id: CCO:B0006180 name: GDF9_HUMAN def: "Growth/differentiation factor 9 precursor" [UniProtKB:O60383] synonym: "GDF-9" EXACT [UniProtKB:O60383] xref: EMBL:AAC08450.1 xref: EMBL:AAH96228.1 xref: EMBL:AAH96229.1 xref: EMBL:AAH96230.1 xref: EMBL:AAH96231.1 xref: UniProtKB:O60383 xref: UniProtKB:Q4VAW5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004691 ! GDF9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008215 ! cdkn2c-gdf9 physical interaction relationship: participates_in CCO:I0008240 ! smpd3-gdf9 physical interaction relationship: participates_in CCO:I0008251 ! ilf3-gdf9 physical interaction relationship: participates_in CCO:I0008255 ! kif22-gdf9 physical interaction relationship: participates_in CCO:I0008274 ! mphosph6-gdf9 physical interaction relationship: participates_in CCO:I0008382 ! dleu1-gdf9 physical interaction relationship: participates_in CCO:I0008419 ! pmf1-gdf9 physical interaction [Term] id: CCO:B0006182 name: CRADD_HUMAN def: "Death domain-containing protein CRADD" [UniProtKB:P78560] synonym: "Caspase and RIP adapter with death domain" EXACT [UniProtKB:P78560] synonym: "RIP-associated protein with a death domain" EXACT [UniProtKB:P78560] xref: EMBL:AAB42217.1 xref: EMBL:AAC50952.1 xref: EMBL:AAH17042.1 xref: UniProtKB:P78560 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004393 ! CRADD_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008217 ! cradd-rif1 physical interaction [Term] id: CCO:B0006183 name: DDX24_HUMAN def: "ATP-dependent RNA helicase DDX24" [UniProtKB:Q9GZR7] synonym: "DEAD box protein 24" EXACT [UniProtKB:Q9GZR7] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9GZR7] xref: EMBL:AAG02169.1 xref: EMBL:AAH08847.1 xref: EMBL:AAH09406.1 xref: EMBL:BAB15079.1 xref: EMBL:CAB66820.1 xref: UniProtKB:Q9GZR7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004457 ! DDX24_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008218 ! ddx24-pin1 physical interaction relationship: transforms_into CCO:B0011467 ! DDX24_HUMAN-Phosphoserine82 relationship: transforms_into CCO:B0011468 ! DDX24_HUMAN-Phosphoserine166 relationship: transforms_into CCO:B0011469 ! DDX24_HUMAN-Phosphoserine192 relationship: transforms_into CCO:B0011470 ! DDX24_HUMAN-Phosphothreonine302 [Term] id: CCO:B0006184 name: GLYC_HUMAN def: "Serine hydroxymethyltransferase, cytosolic" [UniProtKB:P34896] synonym: "EC 2.1.2.1" EXACT [UniProtKB:P34896] synonym: "Glycine hydroxymethyltransferase" EXACT [UniProtKB:P34896] synonym: "Serine methylase" EXACT [UniProtKB:P34896] synonym: "SHMT" EXACT [UniProtKB:P34896] xref: EMBL:AAA36018.1 xref: EMBL:AAA36019.1 xref: EMBL:AAA36020.1 xref: EMBL:AAA63257.1 xref: EMBL:AAH22874.1 xref: EMBL:AAH38598.1 xref: EMBL:CAB54838.1 xref: EMBL:CAB54839.1 xref: EMBL:CAB54840.1 xref: UniProtKB:P34896 xref: UniProtKB:Q9UMD1 xref: UniProtKB:Q9UMD2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004706 ! SHMT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008221 ! dleu1-shmt1 physical interaction relationship: transforms_into CCO:B0011947 ! GLYC_HUMAN-Phosphotyrosine34 [Term] id: CCO:B0006187 name: SH3G3_HUMAN def: "Endophilin-A3" [UniProtKB:Q99963] synonym: "EEN-B2" EXACT [UniProtKB:Q99963] synonym: "Endophilin-3" EXACT [UniProtKB:Q99963] synonym: "SH3 domain protein 2C" EXACT [UniProtKB:Q99963] synonym: "SH3 domain-containing GRB2-like protein 3" EXACT [UniProtKB:Q99963] xref: EMBL:AAC04765.1 xref: EMBL:AAC04766.1 xref: EMBL:AAC04767.1 xref: EMBL:AAC04768.1 xref: EMBL:CAA67978.1 xref: UniProtKB:O43553 xref: UniProtKB:O43554 xref: UniProtKB:Q99963 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005609 ! SH3GL3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008225 ! egfl6-sh3gl3 physical interaction relationship: participates_in CCO:I0008439 ! terf1-sh3gl3 physical interaction [Term] id: CCO:B0006188 name: SH3G2_HUMAN def: "Endophilin-A1" [UniProtKB:Q99962] synonym: "EEN-B1" EXACT [UniProtKB:Q99962] synonym: "Endophilin-1" EXACT [UniProtKB:Q99962] synonym: "SH3 domain protein 2A" EXACT [UniProtKB:Q99962] synonym: "SH3 domain-containing GRB2-like protein 2" EXACT [UniProtKB:Q99962] xref: EMBL:AAC04764.1 xref: EMBL:AAV38488.1 xref: EMBL:CAA67971.1 xref: EMBL:CAB92765.2 xref: EMBL:CAG46883.1 xref: EMBL:CAG46899.1 xref: EMBL:CAH70742.1 xref: UniProtKB:Q99962 xref: UniProtKB:Q9NQK5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005608 ! SH3GL2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008385 ! egfl6-sh3gl2 physical interaction relationship: transforms_into CCO:B0014054 ! SH3G2_HUMAN-Phosphoserine75 [Term] id: CCO:B0006189 name: ETHE1_HUMAN def: "ETHE1 protein, mitochondrial precursor" [UniProtKB:O95571] synonym: "EC 3.-.-.-" EXACT [UniProtKB:O95571] synonym: "Ethylmalonic encephalopathy protein 1" EXACT [UniProtKB:O95571] synonym: "Hepatoma subtracted clone one protein" EXACT [UniProtKB:O95571] xref: EMBL:AAG09063.1 xref: EMBL:AAH08250.1 xref: EMBL:BAA34595.2 xref: UniProtKB:O95571 xref: UniProtKB:Q96HR0 xref: UniProtKB:Q9H001 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004591 ! ETHE1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008231 ! ethe1-rif1 physical interaction [Term] id: CCO:B0006191 name: CCD99_HUMAN def: "Coiled-coil domain-containing protein 99" [UniProtKB:Q96EA4] synonym: "Arsenite-related gene 1 protein" EXACT [UniProtKB:Q96EA4] synonym: "Rrhabdomyosarcoma antigen protein MU-RMS-40.4A" EXACT [UniProtKB:Q96EA4] xref: EMBL:AAG01408.1 xref: EMBL:AAH12568.1 xref: EMBL:AAT44530.1 xref: EMBL:BAA91119.1 xref: EMBL:BAB85022.1 xref: UniProtKB:Q8TEC8 xref: UniProtKB:Q96EA4 xref: UniProtKB:Q9HD44 xref: UniProtKB:Q9NX97 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004239 ! CCDC99_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008234 ! flj20364-gps2 physical interaction relationship: transforms_into CCO:B0010983 ! CCD99_HUMAN-Phosphotyrosine279 relationship: transforms_into CCO:B0010984 ! CCD99_HUMAN-Phosphothreonine487 relationship: transforms_into CCO:B0010985 ! CCD99_HUMAN-Phosphoserine515 relationship: transforms_into CCO:B0010986 ! CCD99_HUMAN-Phosphoserine555 [Term] id: CCO:B0006192 name: FRIL_HUMAN def: "Ferritin light chain" [UniProtKB:P02792] synonym: "Ferritin L subunit" EXACT [UniProtKB:P02792] xref: EMBL:AAA35831.1 xref: EMBL:AAA52439.1 xref: EMBL:AAA52440.1 xref: EMBL:AAH02991.2 xref: EMBL:AAH04245.1 xref: EMBL:AAH08439.1 xref: EMBL:AAH16346.1 xref: EMBL:AAH16354.1 xref: EMBL:AAH18990.1 xref: EMBL:AAH58820.1 xref: EMBL:AAH62708.1 xref: EMBL:CAA27382.1 xref: EMBL:CAA27383.1 xref: EMBL:CAA27384.1 xref: EMBL:CAE11873.1 xref: UniProtKB:P02792 xref: UniProtKB:Q7Z2W1 xref: UniProtKB:Q9BTZ8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004658 ! FTL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008475 ! ftl-gadd45a physical interaction relationship: transforms_into CCO:B0011895 ! FRIL_HUMAN-N-acetylserine2 [Term] id: CCO:B0006193 name: VTDB_HUMAN def: "Vitamin D-binding protein precursor" [UniProtKB:P02774] synonym: "DBP" EXACT [UniProtKB:P02774] synonym: "Gc-globulin" EXACT [UniProtKB:P02774] synonym: "Group-specific component" EXACT [UniProtKB:P02774] synonym: "VDB" EXACT [UniProtKB:P02774] xref: EMBL:AAA19662.2 xref: EMBL:AAA52173.1 xref: EMBL:AAA61704.1 xref: EMBL:AAB29423.1 xref: EMBL:AAD14249.1 xref: EMBL:AAD14250.1 xref: EMBL:CAA26938.1 xref: UniProtKB:P02774 xref: UniProtKB:Q16309 xref: UniProtKB:Q16310 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005909 ! GC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008244 ! gc-rif1 physical interaction [Term] id: CCO:B0006197 name: HSPB3_HUMAN def: "Heat shock protein beta-3" [UniProtKB:Q12988] synonym: "Heat shock 17 kDa protein" EXACT [UniProtKB:Q12988] synonym: "HspB3" EXACT [UniProtKB:Q12988] xref: EMBL:AAD05360.1 xref: EMBL:CAA76848.1 xref: UniProtKB:Q12988 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004840 ! HSPB3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008249 ! hspb3-rif1 physical interaction [Term] id: CCO:B0006198 name: CENPR_HUMAN def: "Centromere protein R" [UniProtKB:Q13352] synonym: "Beta3-endonexin" EXACT [UniProtKB:Q13352] synonym: "CENP-R" EXACT [UniProtKB:Q13352] synonym: "Integrin beta-3-binding protein" EXACT [UniProtKB:Q13352] synonym: "Nuclear receptor-interacting factor 3" EXACT [UniProtKB:Q13352] xref: EMBL:AAC50294.1 xref: EMBL:AAC50295.1 xref: EMBL:AAF00239.1 xref: EMBL:AAH09929.1 xref: EMBL:AAH14385.1 xref: EMBL:CAI15771.1 xref: EMBL:CAI15772.1 xref: EMBL:CAI18958.1 xref: EMBL:CAI18959.1 xref: UniProtKB:Q13352 xref: UniProtKB:Q13353 xref: UniProtKB:Q5RJ42 xref: UniProtKB:Q5RJ44 xref: UniProtKB:Q5RJ45 xref: UniProtKB:Q7KYX2 xref: UniProtKB:Q96CD5 xref: UniProtKB:Q9UKB6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004328 ! ITGB3BP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008252 ! itgb3bp-rif1 physical interaction relationship: participates_in CCO:I0008794 ! itgb3bp-psme1 physical interaction relationship: transforms_into CCO:B0011177 ! CENPR_HUMAN-Phosphoserine28 [Term] id: CCO:B0006200 name: WWC1_HUMAN def: "Protein WWC1" [UniProtKB:Q8IX03] synonym: "HBeAg-binding protein 3" EXACT [UniProtKB:Q8IX03] synonym: "KIBRA" EXACT [UniProtKB:Q8IX03] synonym: "Kidney and brain protein" EXACT [UniProtKB:Q8IX03] synonym: "WW domain-containing protein 1" EXACT [UniProtKB:Q8IX03] xref: EMBL:AAH04394.1 xref: EMBL:AAH17746.1 xref: EMBL:AAO15881.1 xref: EMBL:AAO73817.1 xref: EMBL:AAQ09942.1 xref: EMBL:BAA74892.1 xref: EMBL:CAE45903.1 xref: UniProtKB:O94946 xref: UniProtKB:Q6MZX4 xref: UniProtKB:Q6Y2F8 xref: UniProtKB:Q7Z4G8 xref: UniProtKB:Q8IX03 xref: UniProtKB:Q8WVM4 xref: UniProtKB:Q9BT29 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005935 ! WWC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008254 ! kibra-rif1 physical interaction relationship: transforms_into CCO:B0014699 ! WWC1_HUMAN-Phosphoserine899 relationship: transforms_into CCO:B0014700 ! WWC1_HUMAN-Phosphoserine922 relationship: transforms_into CCO:B0014701 ! WWC1_HUMAN-Phosphothreonine923 relationship: transforms_into CCO:B0014702 ! WWC1_HUMAN-Phosphoserine927 [Term] id: CCO:B0006201 name: IMMT_HUMAN def: "Mitochondrial inner membrane protein" [UniProtKB:Q16891] synonym: "Cell proliferation-inducing gene 4 protein" EXACT [UniProtKB:Q16891] synonym: "Mitofilin" EXACT [UniProtKB:Q16891] synonym: "p87/89" EXACT [UniProtKB:Q16891] xref: EMBL:AAA85336.1 xref: EMBL:AAF73126.1 xref: EMBL:AAH02412.1 xref: EMBL:AAH27458.1 xref: EMBL:AAP69987.1 xref: EMBL:BAA04653.1 xref: EMBL:BAA04654.1 xref: EMBL:BAA04655.1 xref: EMBL:BAA04656.1 xref: EMBL:CAD97612.1 xref: EMBL:CAG33074.1 xref: EMBL:CAH18389.1 xref: UniProtKB:Q14539 xref: UniProtKB:Q15092 xref: UniProtKB:Q16891 xref: UniProtKB:Q68D41 xref: UniProtKB:Q69HW5 xref: UniProtKB:Q6IBL0 xref: UniProtKB:Q7Z3X1 xref: UniProtKB:Q8TAJ5 xref: UniProtKB:Q9P0V2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004890 ! IMMT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008256 ! kif22-immt physical interaction relationship: participates_in CCO:I0008287 ! pfdn1-immt physical interaction relationship: transforms_into CCO:B0012380 ! IMMT_HUMAN-N6-acetyllysine506 [Term] id: CCO:B0006202 name: PJA1_HUMAN def: "E3 ubiquitin-protein ligase Praja1" [UniProtKB:Q8NG27] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q8NG27] synonym: "Praja-1" EXACT [UniProtKB:Q8NG27] synonym: "RING finger protein 70" EXACT [UniProtKB:Q8NG27] xref: EMBL:AAH48323.1 xref: EMBL:AAH75803.1 xref: EMBL:AAI05052.1 xref: EMBL:AAI05054.1 xref: EMBL:AAM53039.1 xref: EMBL:AAM53040.1 xref: EMBL:BAB13928.1 xref: EMBL:CAI41604.1 xref: UniProtKB:Q5JUT9 xref: UniProtKB:Q8NG27 xref: UniProtKB:Q8NG28 xref: UniProtKB:Q9HAC1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005320 ! PJA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008257 ! kif22-pja1 physical interaction [Term] id: CCO:B0006203 name: TM1L1_HUMAN def: "TOM1-like protein 1" [UniProtKB:O75674] synonym: "Src-activating and signaling molecule protein" EXACT [UniProtKB:O75674] synonym: "Target of Myb-like protein 1" EXACT [UniProtKB:O75674] xref: EMBL:CAA08993.1 xref: UniProtKB:O75674 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005795 ! TOM1L1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008258 ! kntc2-tom1l1 physical interaction relationship: transforms_into CCO:B0014415 ! TM1L1_HUMAN-Phosphoserine314 relationship: transforms_into CCO:B0014416 ! TM1L1_HUMAN-Phosphoserine323 relationship: transforms_into CCO:B0014417 ! TM1L1_HUMAN-Phosphotyrosine460 [Term] id: CCO:B0006204 name: MAGD1_HUMAN def: "Melanoma-associated antigen D1" [UniProtKB:Q9Y5V3] synonym: "MAGE tumor antigen CCF" EXACT [UniProtKB:Q9Y5V3] synonym: "MAGE-D1 antigen" EXACT [UniProtKB:Q9Y5V3] synonym: "Neurotrophin receptor-interacting MAGE homolog" EXACT [UniProtKB:Q9Y5V3] xref: EMBL:AAD31421.1 xref: EMBL:AAG09704.1 xref: EMBL:AAG23757.1 xref: EMBL:AAG35551.1 xref: EMBL:AAH14070.1 xref: EMBL:AAH32473.1 xref: EMBL:AAQ14483.1 xref: EMBL:CAB63752.1 xref: EMBL:CAH71560.1 xref: EMBL:CAH71561.1 xref: UniProtKB:Q5VSH6 xref: UniProtKB:Q8IZ84 xref: UniProtKB:Q8WY92 xref: UniProtKB:Q9H352 xref: UniProtKB:Q9HBT4 xref: UniProtKB:Q9UF36 xref: UniProtKB:Q9Y5V3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005020 ! MAGED1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008263 ! maged1-plk1 physical interaction [Term] id: CCO:B0006205 name: CP024_HUMAN def: "Uncharacterized protein C16orf24" [UniProtKB:Q9BQD7] xref: EMBL:AAH01181.1 xref: EMBL:AAH02624.1 xref: EMBL:AAK61248.1 xref: UniProtKB:Q9BQD7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004388 ! C16orf24_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008265 ! c16orf24-tp53 physical interaction [Term] id: CCO:B0006206 name: AF9_HUMAN def: "Protein AF-9" [UniProtKB:P42568] synonym: "ALL1 fused gene from chromosome 9 protein" EXACT [UniProtKB:P42568] synonym: "Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein" EXACT [UniProtKB:P42568] synonym: "YEATS domain-containing protein 3" EXACT [UniProtKB:P42568] xref: EMBL:AAA58361.1 xref: UniProtKB:P42568 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004035 ! MLLT3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008267 ! mllt3-rif1 physical interaction [Term] id: CCO:B0006207 name: MPP3_HUMAN def: "MAGUK p55 subfamily member 3" [UniProtKB:Q13368] synonym: "Discs large homolog 3" EXACT [UniProtKB:Q13368] synonym: "Protein MPP3" EXACT [UniProtKB:Q13368] xref: EMBL:AAB36964.1 xref: EMBL:AAH47017.1 xref: EMBL:AAH56865.1 xref: EMBL:CAJ18313.1 xref: EMBL:CAJ18315.1 xref: UniProtKB:Q13368 xref: UniProtKB:Q4GX05 xref: UniProtKB:Q6PGR3 xref: UniProtKB:Q86SV1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005120 ! MPP3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008275 ! mpp3-mcm2 physical interaction [Term] id: CCO:B0006208 name: RT06_HUMAN def: "Mitochondrial 28S ribosomal protein S6" [UniProtKB:P82932] synonym: "MRP-S6" EXACT [UniProtKB:P82932] synonym: "S6mt" EXACT [UniProtKB:P82932] xref: EMBL:AAH00547.2 xref: EMBL:AAH04976.2 xref: EMBL:AAH10076.1 xref: EMBL:AAH51302.1 xref: EMBL:AAL35739.1 xref: EMBL:BAB40995.1 xref: EMBL:BAB54937.1 xref: UniProtKB:P82932 xref: UniProtKB:Q96Q64 xref: UniProtKB:Q9BSK8 xref: UniProtKB:Q9BW89 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005544 ! MRPS6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008276 ! mrps6-rif1 physical interaction [Term] id: CCO:B0006211 name: TF3C1_HUMAN def: "General transcription factor 3C polypeptide 1" [UniProtKB:Q12789] synonym: "TF3C-alpha" EXACT [UniProtKB:Q12789] synonym: "TFIIIC 220 kDa subunit" EXACT [UniProtKB:Q12789] synonym: "TFIIIC box B-binding subunit" EXACT [UniProtKB:Q12789] synonym: "TFIIIC220" EXACT [UniProtKB:Q12789] synonym: "Transcription factor IIIC subunit alpha" EXACT [UniProtKB:Q12789] xref: EMBL:AAA17985.1 xref: EMBL:AAA85638.1 xref: EMBL:AAB67637.1 xref: EMBL:AAC05811.1 xref: EMBL:AAH44857.1 xref: UniProtKB:Q12789 xref: UniProtKB:Q12838 xref: UniProtKB:Q6DKN9 xref: UniProtKB:Q9Y4W9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005764 ! GTF3C1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008328 ! supt5h-gtf3c1 physical interaction relationship: transforms_into CCO:B0014337 ! TF3C1_HUMAN-Phosphoserine739 relationship: transforms_into CCO:B0014338 ! TF3C1_HUMAN-Phosphoserine751 relationship: transforms_into CCO:B0014339 ! TF3C1_HUMAN-Phosphoserine1062 relationship: transforms_into CCO:B0014340 ! TF3C1_HUMAN-Phosphoserine1068 relationship: transforms_into CCO:B0014341 ! TF3C1_HUMAN-Phosphoserine1653 relationship: transforms_into CCO:B0014342 ! TF3C1_HUMAN-Phosphoserine1865 relationship: transforms_into CCO:B0014343 ! TF3C1_HUMAN-Phosphoserine1868 relationship: transforms_into CCO:B0014344 ! TF3C1_HUMAN-Phosphoserine1969 [Term] id: CCO:B0006212 name: PAEP_HUMAN def: "Glycodelin precursor" [UniProtKB:P09466] synonym: "GD" EXACT [UniProtKB:P09466] synonym: "PAEG" EXACT [UniProtKB:P09466] synonym: "PEG" EXACT [UniProtKB:P09466] synonym: "Placental protein 14" EXACT [UniProtKB:P09466] synonym: "PP14" EXACT [UniProtKB:P09466] synonym: "Pregnancy-associated endometrial alpha-2 globulin" EXACT [UniProtKB:P09466] synonym: "Progestagen-associated endometrial protein" EXACT [UniProtKB:P09466] synonym: "Progesterone-associated endometrial protein" EXACT [UniProtKB:P09466] xref: EMBL:AAA35801.1 xref: EMBL:AAA35802.1 xref: EMBL:AAA60147.1 xref: EMBL:AAA60148.1 xref: EMBL:AAH69451.1 xref: EMBL:AAH69562.1 xref: EMBL:AAI12305.1 xref: EMBL:AAI13729.1 xref: EMBL:CAB43305.1 xref: EMBL:CAI17197.1 xref: UniProtKB:P09466 xref: UniProtKB:Q5T6T1 xref: UniProtKB:Q9UG92 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005255 ! PAEP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008284 ! paep-rif1 physical interaction relationship: participates_in CCO:I0008813 ! ube2e1-paep physical interaction [Term] id: CCO:B0006214 name: HIP1_HUMAN def: "Huntingtin-interacting protein 1" [UniProtKB:O00291] synonym: "HIP-I" EXACT [UniProtKB:O00291] xref: EMBL:AAC33564.1 xref: EMBL:AAC51257.1 xref: EMBL:AAL87037.1 xref: EMBL:CAA70574.1 xref: UniProtKB:O00291 xref: UniProtKB:O00328 xref: UniProtKB:Q8TDL4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004807 ! HIP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008286 ! pfdn1-hip1 physical interaction [Term] id: CCO:B0006215 name: PSME1_HUMAN def: "Proteasome activator complex subunit 1" [UniProtKB:Q06323] synonym: "11S regulator complex subunit alpha" EXACT [UniProtKB:Q06323] synonym: "Activator of multicatalytic protease subunit 1" EXACT [UniProtKB:Q06323] synonym: "IGUP I-5111" EXACT [UniProtKB:Q06323] synonym: "Interferon gamma up-regulated I-5111 protein" EXACT [UniProtKB:Q06323] synonym: "PA28a" EXACT [UniProtKB:Q06323] synonym: "PA28alpha" EXACT [UniProtKB:Q06323] synonym: "Proteasome activator 28 subunit alpha" EXACT [UniProtKB:Q06323] synonym: "REG-alpha" EXACT [UniProtKB:Q06323] xref: EMBL:AAA16521.1 xref: EMBL:AAA53230.1 xref: EMBL:AAF02217.1 xref: EMBL:AAH00352.1 xref: EMBL:AAH07503.1 xref: EMBL:AAV38144.1 xref: EMBL:BAA28836.1 xref: UniProtKB:Q06323 xref: UniProtKB:Q9UEF4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005393 ! PSME1_human relationship: has_function CCO:F0001986 ! proteasome activator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0000548 ! proteasome activator complex relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: participates_in CCO:I0008288 ! pfdn1-psme1 physical interaction relationship: participates_in CCO:I0008698 ! psme1-psme2 physical interaction relationship: participates_in CCO:I0008794 ! itgb3bp-psme1 physical interaction relationship: participates_in CCO:I0008796 ! psme1-chd3 physical interaction relationship: participates_in CCO:I0008798 ! psme1-psme1 physical interaction relationship: participates_in CCO:I0008799 ! psme1-vcl physical interaction relationship: participates_in CCO:I0008800 ! psme1-vim physical interaction relationship: participates_in CCO:I0008816 ! usp22-psme1 physical interaction relationship: participates_in CCO:I0008819 ! c2f-psme1 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0006216 name: PKHA4_HUMAN def: "Pleckstrin homology domain-containing family A member 4" [UniProtKB:Q9H4M7] synonym: "PEPP-1" EXACT [UniProtKB:Q9H4M7] synonym: "Phosphoinositol 3-phosphate-binding protein 1" EXACT [UniProtKB:Q9H4M7] xref: EMBL:AAG01896.1 xref: EMBL:AAH24157.1 xref: EMBL:AAH33832.1 xref: EMBL:AAH64601.1 xref: UniProtKB:Q8N4M8 xref: UniProtKB:Q8N658 xref: UniProtKB:Q9H4M7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005325 ! PLEKHA4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008290 ! plekha4-rif1 physical interaction [Term] id: CCO:B0006217 name: SCG1_HUMAN def: "Secretogranin-1 precursor" [UniProtKB:P05060] synonym: "CgB" EXACT [UniProtKB:P05060] synonym: "Chromogranin-B" EXACT [UniProtKB:P05060] synonym: "Secretogranin I" EXACT [UniProtKB:P05060] synonym: "SgI" EXACT [UniProtKB:P05060] xref: EMBL:AAH00375.1 xref: EMBL:CAA68271.1 xref: EMBL:CAB55272.1 xref: EMBL:CAC34360.1 xref: UniProtKB:P05060 xref: UniProtKB:Q9BQV6 xref: UniProtKB:Q9UJA6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005572 ! CHGB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008295 ! pold1-chgb physical interaction relationship: participates_in CCO:I0008302 ! pten-chgb physical interaction relationship: transforms_into CCO:B0013968 ! SCG1_HUMAN-Phosphoserine149 relationship: transforms_into CCO:B0013969 ! SCG1_HUMAN-N6-acetyllysine153 relationship: transforms_into CCO:B0013971 ! SCG1_HUMAN-Phosphoserine182 relationship: transforms_into CCO:B0013972 ! SCG1_HUMAN-Phosphoserine183 relationship: transforms_into CCO:B0013973 ! SCG1_HUMAN-Phosphoserine259 relationship: transforms_into CCO:B0013974 ! SCG1_HUMAN-Phosphoserine263 relationship: transforms_into CCO:B0013975 ! SCG1_HUMAN-Phosphoserine311 relationship: transforms_into CCO:B0013976 ! SCG1_HUMAN-Phosphoserine335 relationship: transforms_into CCO:B0013977 ! SCG1_HUMAN-Sulfotyrosine341 relationship: transforms_into CCO:B0013978 ! SCG1_HUMAN-Phosphoserine377 relationship: transforms_into CCO:B0013979 ! SCG1_HUMAN-Phosphoserine405 relationship: transforms_into CCO:B0013980 ! SCG1_HUMAN-Phosphoserine617 relationship: transforms_into CCO:B0013981 ! SCG1_HUMAN-Phosphoserine626 relationship: transforms_into CCO:B0041181 ! SCG1_HUMAN-Phosphothreonine79 relationship: transforms_into CCO:B0041182 ! SCG1_HUMAN-Phosphoserine99 relationship: transforms_into CCO:B0041183 ! SCG1_HUMAN-Phosphoserine100 relationship: transforms_into CCO:B0041184 ! SCG1_HUMAN-Phosphoserine293 relationship: transforms_into CCO:B0041185 ! SCG1_HUMAN-Phosphoserine294 relationship: transforms_into CCO:B0041186 ! SCG1_HUMAN-Phosphoserine380 relationship: transforms_into CCO:B0041187 ! SCG1_HUMAN-Sulfotyrosine471 relationship: transforms_into CCO:B0041188 ! SCG1_HUMAN-Sulfotyrosine474 relationship: transforms_into CCO:B0041189 ! SCG1_HUMAN-Phosphoserine533 relationship: transforms_into CCO:B0041190 ! SCG1_HUMAN-Phosphoserine534 relationship: transforms_into CCO:B0041191 ! SCG1_HUMAN-Sulfotyrosine566 relationship: transforms_into CCO:B0041192 ! SCG1_HUMAN-Sulfotyrosine568 relationship: transforms_into CCO:B0041193 ! SCG1_HUMAN-Phosphoserine631 [Term] id: CCO:B0006218 name: PQBP1_HUMAN def: "Polyglutamine-binding protein 1" [UniProtKB:O60828] synonym: "38 kDa nuclear protein containing a WW domain" EXACT [UniProtKB:O60828] synonym: "Npw38" EXACT [UniProtKB:O60828] synonym: "Polyglutamine tract-binding protein 1" EXACT [UniProtKB:O60828] synonym: "PQBP-1" EXACT [UniProtKB:O60828] xref: EMBL:AAH12358.1 xref: EMBL:BAA76400.1 xref: EMBL:BAB16702.1 xref: EMBL:BAB16703.1 xref: EMBL:BAB16704.1 xref: EMBL:BAB16705.1 xref: EMBL:BAB16706.1 xref: EMBL:BAB16707.1 xref: EMBL:BAB16708.1 xref: EMBL:BAB16709.1 xref: EMBL:CAA06750.1 xref: EMBL:CAB44309.1 xref: EMBL:CAJ00537.1 xref: EMBL:CAJ00538.1 xref: EMBL:CAJ00539.1 xref: EMBL:CAJ00540.1 xref: EMBL:CAJ00541.1 xref: EMBL:CAJ00542.1 xref: EMBL:CAJ00543.1 xref: EMBL:CAJ00544.1 xref: EMBL:CAJ00545.1 xref: EMBL:CAJ00546.1 xref: EMBL:CAJ00547.1 xref: EMBL:CAJ00548.1 xref: EMBL:CAJ00549.1 xref: EMBL:CAJ00550.1 xref: UniProtKB:O60828 xref: UniProtKB:Q4VY25 xref: UniProtKB:Q4VY26 xref: UniProtKB:Q4VY27 xref: UniProtKB:Q4VY29 xref: UniProtKB:Q4VY30 xref: UniProtKB:Q4VY34 xref: UniProtKB:Q4VY35 xref: UniProtKB:Q4VY36 xref: UniProtKB:Q4VY37 xref: UniProtKB:Q4VY38 xref: UniProtKB:Q9GZP2 xref: UniProtKB:Q9GZU4 xref: UniProtKB:Q9GZZ4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005371 ! PQBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008298 ! pqbp1-rif1 physical interaction [Term] id: CCO:B0006219 name: PSB10_HUMAN def: "Proteasome subunit beta type-10 precursor" [UniProtKB:P40306] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P40306] synonym: "Macropain subunit MECl-1" EXACT [UniProtKB:P40306] synonym: "Multicatalytic endopeptidase complex subunit MECl-1" EXACT [UniProtKB:P40306] synonym: "Proteasome MECl-1" EXACT [UniProtKB:P40306] synonym: "Proteasome subunit beta-2i" EXACT [UniProtKB:P40306] xref: EMBL:AAH17198.1 xref: EMBL:AAH52369.1 xref: EMBL:AAV38528.1 xref: EMBL:AAV38529.1 xref: EMBL:CAA50709.1 xref: EMBL:CAA73982.1 xref: UniProtKB:P40306 xref: UniProtKB:Q5U098 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005387 ! PSMB10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008300 ! psmb10-ptn physical interaction relationship: participates_in CCO:I0008727 ! alpha1-beta2i physical interaction relationship: participates_in CCO:I0008747 ! beta2i-beta3 physical interaction relationship: participates_in CCO:I0008748 ! beta3-beta2i physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0006220 name: ANGI_HUMAN def: "Angiogenin precursor" [UniProtKB:P03950] synonym: "EC 3.1.27.-" EXACT [UniProtKB:P03950] synonym: "Ribonuclease 5" EXACT [UniProtKB:P03950] synonym: "RNase 5" EXACT [UniProtKB:P03950] xref: EMBL:AAA51678.1 xref: EMBL:AAH54880.1 xref: EMBL:AAL67710.1 xref: EMBL:AAL67711.1 xref: EMBL:AAL67712.1 xref: EMBL:AAL67713.1 xref: EMBL:AAL67714.1 xref: UniProtKB:P03950 xref: UniProtKB:Q8WXE7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004059 ! ANG_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008301 ! pten-ang physical interaction relationship: transforms_into CCO:B0010528 ! ANGI_HUMAN-Pyrrolidone carboxylic acid25 [Term] id: CCO:B0006221 name: HBA_HUMAN def: "Hemoglobin subunit alpha" [UniProtKB:P69905] synonym: "Alpha-globin" EXACT [UniProtKB:P69905] synonym: "Hemoglobin alpha chain" EXACT [UniProtKB:P69905] xref: EMBL:AAB59407.1 xref: EMBL:AAB59408.1 xref: EMBL:AAC72839.1 xref: EMBL:AAC97373.1 xref: EMBL:AAF72612.1 xref: EMBL:AAH05931.1 xref: EMBL:AAH08572.1 xref: EMBL:AAH32122.1 xref: EMBL:AAH50661.1 xref: EMBL:AAI01847.1 xref: EMBL:AAI01849.1 xref: EMBL:AAK37554.1 xref: EMBL:AAK61215.1 xref: EMBL:AAK61216.1 xref: EMBL:AAM83102.1 xref: EMBL:AAN04486.1 xref: EMBL:ABD95910.1 xref: EMBL:ABD95911.1 xref: EMBL:ABF56144.1 xref: EMBL:CAA23748.1 xref: EMBL:CAA23750.1 xref: EMBL:CAA23752.1 xref: EMBL:CAA23774.1 xref: EMBL:CAB06554.1 xref: EMBL:CAB06555.1 xref: UniProtKB:P01922 xref: UniProtKB:P69905 xref: UniProtKB:Q3MIF5 xref: UniProtKB:Q96KF1 xref: UniProtKB:Q9NYR7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004779 ! HBA1_human relationship: encoded_by CCO:G0004780 ! HBA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008304 ! pten-hba1 physical interaction [Term] id: CCO:B0006222 name: RAB1A_HUMAN def: "Ras-related protein Rab-1A" [UniProtKB:P62820] synonym: "YPT1-related protein" EXACT [UniProtKB:P62820] xref: EMBL:AAA60240.1 xref: EMBL:AAH00905.1 xref: EMBL:AAM21077.1 xref: EMBL:BAB71048.1 xref: EMBL:CAB43369.1 xref: EMBL:CAE11872.1 xref: UniProtKB:P11476 xref: UniProtKB:P62820 xref: UniProtKB:Q96N61 xref: UniProtKB:Q9Y3T2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005409 ! RAB1A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008305 ! rab1a-cdkn1a physical interaction relationship: participates_in CCO:I0008492 ! rab1a-mapre3 physical interaction relationship: participates_in CCO:I0008824 ! rab1a-psmd7 physical interaction relationship: transforms_into CCO:B0013655 ! RAB1A_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0013656 ! RAB1A_HUMAN-Phosphoserine194 [Term] id: CCO:B0006223 name: RB27A_HUMAN def: "Ras-related protein Rab-27A" [UniProtKB:P51159] synonym: "GTP-binding protein Ram" EXACT [UniProtKB:P51159] synonym: "Rab-27" EXACT [UniProtKB:P51159] xref: EMBL:AAC50271.2 xref: EMBL:AAC51195.1 xref: EMBL:AAD43049.1 xref: EMBL:AAD47629.1 xref: EMBL:AAI07681.1 xref: EMBL:AAL39097.1 xref: EMBL:AAM21101.1 xref: EMBL:CAG38735.1 xref: EMBL:CAG46494.1 xref: UniProtKB:O00195 xref: UniProtKB:P51159 xref: UniProtKB:Q6FI40 xref: UniProtKB:Q9UIR9 xref: UniProtKB:Q9Y5U3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005437 ! RAB27A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008306 ! rab27a-rif1 physical interaction relationship: transforms_into CCO:B0013718 ! RB27A_HUMAN-Cysteine methyl ester221 [Term] id: CCO:B0006224 name: RECQ5_HUMAN def: "ATP-dependent DNA helicase Q5" [UniProtKB:O94762] synonym: "EC 3.6.1.-" EXACT [UniProtKB:O94762] synonym: "RecQ protein-like 5" EXACT [UniProtKB:O94762] synonym: "RecQ5" EXACT [UniProtKB:O94762] xref: EMBL:AAD43061.1 xref: EMBL:AAD43062.1 xref: EMBL:AAH16911.1 xref: EMBL:BAA74454.1 xref: EMBL:BAA95952.1 xref: EMBL:BAA95953.1 xref: EMBL:BAA95954.1 xref: UniProtKB:O94762 xref: UniProtKB:Q9P1W7 xref: UniProtKB:Q9UNC8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005462 ! RECQL5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008308 ! recql5-plk1 physical interaction relationship: participates_in CCO:I0008426 ! recql5-mtss1 physical interaction [Term] id: CCO:B0006225 name: ARFG1_HUMAN def: "ADP-ribosylation factor GTPase-activating protein 1" [UniProtKB:Q8N6T3] synonym: "ADP-ribosylation factor 1 GTPase-activating protein" EXACT [UniProtKB:Q8N6T3] synonym: "ARF1 GAP" EXACT [UniProtKB:Q8N6T3] synonym: "ARF1-directed GTPase-activating protein" EXACT [UniProtKB:Q8N6T3] synonym: "GAP protein" EXACT [UniProtKB:Q8N6T3] xref: EMBL:AAH00786.1 xref: EMBL:AAH06085.1 xref: EMBL:AAH11876.1 xref: EMBL:AAH28233.1 xref: EMBL:BAA88117.1 xref: EMBL:BAA91796.1 xref: EMBL:BAB55009.1 xref: EMBL:BAB55113.1 xref: EMBL:CAB70901.1 xref: UniProtKB:Q6PK71 xref: UniProtKB:Q8N6T3 xref: UniProtKB:Q96KC4 xref: UniProtKB:Q96T02 xref: UniProtKB:Q9NSU3 xref: UniProtKB:Q9NVF6 xref: UniProtKB:Q9UIL0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004089 ! ARFGAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008309 ! rgs2-arfgap1 physical interaction relationship: transforms_into CCO:B0010589 ! ARFG1_HUMAN-Phosphothreonine135 relationship: transforms_into CCO:B0010590 ! ARFG1_HUMAN-Phosphothreonine189 relationship: transforms_into CCO:B0010591 ! ARFG1_HUMAN-Phosphoserine246 relationship: transforms_into CCO:B0010592 ! ARFG1_HUMAN-Phosphoserine343 relationship: transforms_into CCO:B0010593 ! ARFG1_HUMAN-Phosphoserine345 relationship: transforms_into CCO:B0010594 ! ARFG1_HUMAN-Phosphoserine348 relationship: transforms_into CCO:B0010595 ! ARFG1_HUMAN-Phosphoserine361 [Term] id: CCO:B0006226 name: DYL1_HUMAN def: "Dynein light chain 1, cytoplasmic" [UniProtKB:P63167] synonym: "8 kDa dynein light chain" EXACT [UniProtKB:P63167] synonym: "DLC8" EXACT [UniProtKB:P63167] synonym: "Dynein light chain LC8-type 1" EXACT [UniProtKB:P63167] synonym: "PIN" EXACT [UniProtKB:P63167] synonym: "Protein inhibitor of neuronal nitric oxide synthase" EXACT [UniProtKB:P63167] xref: EMBL:AAB04149.1 xref: EMBL:CAG28600.1 xref: UniProtKB:P63167 xref: UniProtKB:Q15701 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004527 ! DYNLL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008310 ! rgs2-dncl1 physical interaction [Term] id: CCO:B0006227 name: PRKN2_HUMAN def: "E3 ubiquitin-protein ligase parkin" [UniProtKB:O60260] synonym: "EC 6.3.2.-" EXACT [UniProtKB:O60260] synonym: "Parkinson disease protein 2" EXACT [UniProtKB:O60260] synonym: "Parkinson juvenile disease protein 2" EXACT [UniProtKB:O60260] xref: EMBL:AAH22014.1 xref: EMBL:AAM21457.1 xref: EMBL:AAM21458.1 xref: EMBL:AAM21461.1 xref: EMBL:AAS88422.1 xref: EMBL:BAA25751.1 xref: EMBL:CAH73681.1 xref: EMBL:CAI21385.1 xref: EMBL:CAI23601.1 xref: UniProtKB:O60260 xref: UniProtKB:Q5TFV8 xref: UniProtKB:Q6Q2I6 xref: UniProtKB:Q8NI41 xref: UniProtKB:Q8NI43 xref: UniProtKB:Q8NI44 xref: UniProtKB:Q8WW07 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005377 ! PARK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008311 ! rgs2-park2 physical interaction relationship: participates_in CCO:I0008415 ! park2-rad1 physical interaction [Term] id: CCO:B0006228 name: GLU2B_HUMAN def: "Glucosidase 2 subunit beta precursor" [UniProtKB:P14314] synonym: "80K-H protein" EXACT [UniProtKB:P14314] synonym: "Glucosidase II subunit beta" EXACT [UniProtKB:P14314] synonym: "PKCSH" EXACT [UniProtKB:P14314] synonym: "Protein kinase C substrate, 60.1 kDa protein, heavy chain" EXACT [UniProtKB:P14314] xref: EMBL:AAA52493.1 xref: EMBL:AAA98668.1 xref: EMBL:AAF66686.1 xref: EMBL:AAH13586.1 xref: EMBL:AAH15154.1 xref: EMBL:AAP88860.1 xref: UniProtKB:P14314 xref: UniProtKB:Q96BU9 xref: UniProtKB:Q96D06 xref: UniProtKB:Q9P0W9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004704 ! PRKCSH_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008312 ! rgs2-prkcsh physical interaction relationship: transforms_into CCO:B0011942 ! GLU2B_HUMAN-Phosphoserine89 relationship: transforms_into CCO:B0011943 ! GLU2B_HUMAN-Phosphoserine383 relationship: transforms_into CCO:B0011944 ! GLU2B_HUMAN-Phosphoserine390 relationship: transforms_into CCO:B0011945 ! GLU2B_HUMAN-Phosphoserine434 [Term] id: CCO:B0006229 name: RIT1_HUMAN def: "GTP-binding protein Rit1" [UniProtKB:Q92963] synonym: "Ras-like protein expressed in many tissues" EXACT [UniProtKB:Q92963] synonym: "Ras-like without CAAX protein 1" EXACT [UniProtKB:Q92963] xref: EMBL:AAB42213.1 xref: EMBL:AAB64246.1 xref: EMBL:AAD13021.1 xref: EMBL:AAM12637.1 xref: EMBL:CAA68851.1 xref: UniProtKB:O00646 xref: UniProtKB:O00720 xref: UniProtKB:Q92963 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005495 ! RIT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008314 ! rit1-rif1 physical interaction [Term] id: CCO:B0006230 name: RNF10_HUMAN def: "RING finger protein 10" [UniProtKB:Q8N5U6] xref: EMBL:AAH16622.1 xref: EMBL:AAH31596.1 xref: EMBL:AAI01710.1 xref: EMBL:AAI01716.1 xref: EMBL:AAP35620.1 xref: EMBL:BAA13392.2 xref: EMBL:BAA84708.1 xref: EMBL:CAB97533.1 xref: UniProtKB:Q8N5U6 xref: UniProtKB:Q92550 xref: UniProtKB:Q9NPP8 xref: UniProtKB:Q9ULW4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005519 ! RNF10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008315 ! rnf10-rif1 physical interaction [Term] id: CCO:B0006231 name: RL37A_HUMAN def: "60S ribosomal protein L37a" [UniProtKB:P61513] xref: EMBL:AAA60280.1 xref: EMBL:AAH00555.2 xref: EMBL:AAH14262.1 xref: EMBL:AAH16748.1 xref: EMBL:AAH82239.1 xref: EMBL:CAA47244.1 xref: UniProtKB:P12751 xref: UniProtKB:P61513 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005506 ! RPL37A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008317 ! rpl37a-rif1 physical interaction [Term] id: CCO:B0006232 name: RIR1_HUMAN def: "Ribonucleoside-diphosphate reductase large subunit" [UniProtKB:P23921] synonym: "EC 1.17.4.1" EXACT [UniProtKB:P23921] synonym: "Ribonucleoside-diphosphate reductase subunit M1" EXACT [UniProtKB:P23921] synonym: "Ribonucleotide reductase large subunit" EXACT [UniProtKB:P23921] xref: EMBL:AAD37491.1 xref: EMBL:AAH06498.1 xref: EMBL:CAA42118.1 xref: EMBL:CAA42180.1 xref: UniProtKB:P23921 xref: UniProtKB:Q9UNN2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005494 ! RRM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008318 ! rrm1-rif1 physical interaction [Term] id: CCO:B0006233 name: PDPK1_HUMAN def: "3-phosphoinositide-dependent protein kinase 1" [UniProtKB:O15530] synonym: "EC 2.7.11.1" EXACT [UniProtKB:O15530] synonym: "hPDK1" EXACT [UniProtKB:O15530] xref: EMBL:AAC51825.1 xref: EMBL:AAH12103.1 xref: EMBL:CAA75341.1 xref: UniProtKB:O15530 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005294 ! PDPK1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008320 ! pnn-pdpk1 physical interaction relationship: transforms_into CCO:B0013476 ! PDPK1_HUMAN-Phosphotyrosine9 relationship: transforms_into CCO:B0013477 ! PDPK1_HUMAN-Phosphoserine25 relationship: transforms_into CCO:B0013478 ! PDPK1_HUMAN-Phosphoserine241 relationship: transforms_into CCO:B0013479 ! PDPK1_HUMAN-Phosphothreonine245 relationship: transforms_into CCO:B0013480 ! PDPK1_HUMAN-Phosphotyrosine373 relationship: transforms_into CCO:B0013481 ! PDPK1_HUMAN-Phosphotyrosine376 relationship: transforms_into CCO:B0013482 ! PDPK1_HUMAN-Phosphoserine393 relationship: transforms_into CCO:B0013483 ! PDPK1_HUMAN-Phosphoserine396 relationship: transforms_into CCO:B0013484 ! PDPK1_HUMAN-Phosphoserine410 [Term] id: CCO:B0006234 name: S25BP_HUMAN def: "SNARE-associated protein Snapin" [UniProtKB:O95295] synonym: "SNAP-associated protein" EXACT [UniProtKB:O95295] synonym: "Synaptosomal-associated protein 25-binding protein" EXACT [UniProtKB:O95295] xref: EMBL:AAD11417.1 xref: EMBL:AAH00761.1 xref: EMBL:AAH04494.1 xref: EMBL:AAP35399.1 xref: EMBL:BAB14927.1 xref: UniProtKB:O95295 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005557 ! SNAPAP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008321 ! snapap-spag5 physical interaction relationship: transforms_into CCO:B0013952 ! S25BP_HUMAN-Phosphoserine50 relationship: transforms_into CCO:B0013953 ! S25BP_HUMAN-Phosphoserine133 [Term] id: CCO:B0006236 name: SPG7_HUMAN def: "Paraplegin" [UniProtKB:Q9UQ90] synonym: "EC 3.4.24.-" EXACT [UniProtKB:Q9UQ90] synonym: "Spastic paraplegia protein 7" EXACT [UniProtKB:Q9UQ90] xref: EMBL:AAD28099.1 xref: EMBL:AAH35929.1 xref: EMBL:AAH36104.1 xref: EMBL:CAA76314.1 xref: UniProtKB:O75756 xref: UniProtKB:Q2TB70 xref: UniProtKB:Q58F00 xref: UniProtKB:Q96IB0 xref: UniProtKB:Q9UQ90 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005658 ! SPG7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008323 ! spg7-rif1 physical interaction relationship: transforms_into CCO:B0014175 ! SPG7_HUMAN-Nitrated tyrosine505 [Term] id: CCO:B0006238 name: Q6GVN4_HUMAN def: "Hepatocellular carcinoma-associated antigen 59" [UniProtKB:Q6GVN4] xref: EMBL:AAT46619.1 xref: UniProtKB:Q6GVN4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006005 ! C9orf78_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008327 ! supt5h-c9orf78 physical interaction [Term] id: CCO:B0006239 name: RED_HUMAN def: "Protein Red" [UniProtKB:Q13123] synonym: "Cytokine IK" EXACT [UniProtKB:Q13123] synonym: "IK factor" EXACT [UniProtKB:Q13123] synonym: "Protein RER" EXACT [UniProtKB:Q13123] xref: EMBL:AAB32531.1 xref: EMBL:CAA06607.1 xref: UniProtKB:Q13123 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005463 ! IK_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008329 ! supt5h-ik physical interaction relationship: transforms_into CCO:B0013818 ! RED_HUMAN-Phosphothreonine485 [Term] id: CCO:B0006240 name: PNO1_HUMAN def: "RNA-binding protein PNO1" [UniProtKB:Q9NRX1] xref: EMBL:AAF80763.1 xref: EMBL:AAH08304.1 xref: EMBL:AAH18152.1 xref: EMBL:AAK29434.1 xref: EMBL:AAY14714.1 xref: EMBL:BAD96838.1 xref: UniProtKB:Q53G13 xref: UniProtKB:Q8WVB8 xref: UniProtKB:Q9NRX1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005349 ! PNO1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008330 ! supt5h-loc56902 physical interaction [Term] id: CCO:B0006241 name: PHYIP_HUMAN def: "Phytanoyl-CoA hydroxylase-interacting protein" [UniProtKB:Q92561] synonym: "PAHX-AP1" EXACT [UniProtKB:Q92561] synonym: "PAHXAP1" EXACT [UniProtKB:Q92561] synonym: "Phytanoyl-CoA hydroxylase-associated protein 1" EXACT [UniProtKB:Q92561] xref: EMBL:AAH34034.1 xref: EMBL:AAH35940.1 xref: EMBL:BAA13402.2 xref: UniProtKB:Q8N4I9 xref: UniProtKB:Q92561 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005309 ! PHYHIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008331 ! supt5h-phyhip physical interaction relationship: participates_in CCO:I0008416 ! phyhip-skb1 physical interaction [Term] id: CCO:B0006244 name: TDGF1_HUMAN def: "Teratocarcinoma-derived growth factor 1 precursor" [UniProtKB:P13385] synonym: "CRGF" EXACT [UniProtKB:P13385] synonym: "Cripto-1 growth factor" EXACT [UniProtKB:P13385] synonym: "Epidermal growth factor-like cripto protein CR1" EXACT [UniProtKB:P13385] xref: EMBL:AAA61134.1 xref: EMBL:CAA32467.1 xref: UniProtKB:P13385 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005756 ! TDGF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008336 ! tdgf1-rif1 physical interaction [Term] id: CCO:B0006245 name: TINF2_HUMAN def: "TERF1-interacting nuclear factor 2" [UniProtKB:Q9BSI4] synonym: "TRF1-interacting nuclear protein 2" EXACT [UniProtKB:Q9BSI4] xref: EMBL:AAF18439.1 xref: EMBL:AAH05030.1 xref: EMBL:AAH19343.1 xref: EMBL:BAB14440.1 xref: UniProtKB:Q9BSI4 xref: UniProtKB:Q9H904 xref: UniProtKB:Q9UHC2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005783 ! TINF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008338 ! terf1-tinf2 physical interaction [Term] id: CCO:B0006246 name: TGIF1_HUMAN def: "Homeobox protein TGIF1" [UniProtKB:Q15583] synonym: "5'-TG-3'-interacting factor 1" EXACT [UniProtKB:Q15583] xref: EMBL:AAF81643.1 xref: EMBL:AAH00814.1 xref: EMBL:AAH31268.1 xref: EMBL:CAA61897.1 xref: EMBL:CAG29329.1 xref: UniProtKB:Q15583 xref: UniProtKB:Q6ICR0 xref: UniProtKB:Q8N5X9 xref: UniProtKB:Q9NRS0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005777 ! TGIF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008339 ! tgif-rif1 physical interaction [Term] id: CCO:B0006247 name: Q6IAN9_HUMAN def: "TM4SF6 protein" [UniProtKB:Q6IAN9] synonym: "Tetraspanin 6, isoform CRA_b" EXACT [UniProtKB:Q6IAN9] xref: EMBL:CAG33396.1 xref: EMBL:EAX02811.1 xref: UniProtKB:Q6IAN9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006007 ! TM4SF6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008340 ! tm4sf6-rif1 physical interaction [Term] id: CCO:B0006248 name: RM20_HUMAN def: "39S ribosomal protein L20, mitochondrial precursor" [UniProtKB:Q9BYC9] synonym: "L20mt" EXACT [UniProtKB:Q9BYC9] synonym: "MRP-L20" EXACT [UniProtKB:Q9BYC9] xref: EMBL:AAH09515.1 xref: EMBL:AAH14316.1 xref: EMBL:AAH59945.1 xref: EMBL:BAB40849.1 xref: EMBL:CAI22658.1 xref: UniProtKB:Q9BYC9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005514 ! MRPL20_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008343 ! tp53bp2-mrpl20 physical interaction [Term] id: CCO:B0006249 name: CG036_HUMAN def: "Uncharacterized protein C7orf36" [UniProtKB:Q9NRH1] xref: EMBL:AAF86946.1 xref: EMBL:AAH22043.1 xref: EMBL:AAQ96864.1 xref: EMBL:CAG33479.1 xref: UniProtKB:Q6IAF7 xref: UniProtKB:Q8WVZ5 xref: UniProtKB:Q9NRH1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004338 ! C7orf36_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008344 ! tpd52l1-c7orf36 physical interaction [Term] id: CCO:B0006251 name: Q8N3Z8_HUMAN def: "TRBV21-1 protein" [UniProtKB:Q8N3Z8] xref: EMBL:AAH36926.1 xref: UniProtKB:Q8N3Z8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006022 ! TRBV21-1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008346 ! trbv21_1-rif1 physical interaction [Term] id: CCO:B0006252 name: ULK2_HUMAN def: "Serine/threonine-protein kinase ULK2" [UniProtKB:Q8IYT8] synonym: "EC 2.7.11.1" EXACT [UniProtKB:Q8IYT8] synonym: "Unc-51-like kinase 2" EXACT [UniProtKB:Q8IYT8] xref: EMBL:AAH34988.1 xref: EMBL:BAA31598.2 xref: UniProtKB:O75119 xref: UniProtKB:Q8IYT8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005882 ! ULK2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008350 ! ulk2-nasp physical interaction [Term] id: CCO:B0006253 name: ZCH10_HUMAN def: "Zinc finger CCHC domain-containing protein 10" [UniProtKB:Q8TBK6] xref: EMBL:AAH05211.1 xref: EMBL:AAH22443.1 xref: EMBL:BAA90946.1 xref: UniProtKB:Q8TBK6 xref: UniProtKB:Q9NXR4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005954 ! ZCCHC10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008351 ! zcchc10-tp53 physical interaction relationship: participates_in CCO:I0008447 ! zcchc10-pin1 physical interaction relationship: participates_in CCO:I0008679 ! psme3-zcchc10 physical interaction [Term] id: CCO:B0006256 name: ARL4D_HUMAN def: "ADP-ribosylation factor-like protein 4D" [UniProtKB:P49703] synonym: "ADP-ribosylation factor-like protein 4L" EXACT [UniProtKB:P49703] xref: EMBL:AAA57126.1 xref: EMBL:AAA93229.1 xref: EMBL:AAH00043.1 xref: EMBL:BAB91080.1 xref: UniProtKB:P49703 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004096 ! ARL4D_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008355 ! arf4l-eml4 physical interaction [Term] id: CCO:B0006259 name: BOC_HUMAN def: "Brother of CDO precursor" [UniProtKB:Q9BWV1] synonym: "Protein BOC" EXACT [UniProtKB:Q9BWV1] xref: EMBL:AAK14795.1 xref: EMBL:AAQ88694.1 xref: EMBL:BAC03436.1 xref: EMBL:BAC11057.1 xref: UniProtKB:Q6UXJ5 xref: UniProtKB:Q8N2P7 xref: UniProtKB:Q8NF26 xref: UniProtKB:Q9BWV1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004179 ! BOC_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008362 ! boc-rif1 physical interaction [Term] id: CCO:B0006260 name: NEP1_HUMAN def: "Probable ribosome biogenesis protein NEP1" [UniProtKB:Q92979] synonym: "Nucleolar protein EMG1 homolog" EXACT [UniProtKB:Q92979] synonym: "Protein C2f" EXACT [UniProtKB:Q92979] xref: EMBL:AAB51325.1 xref: EMBL:AAC51641.1 xref: EMBL:AAH55314.1 xref: UniProtKB:O00675 xref: UniProtKB:O00726 xref: UniProtKB:Q92979 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005184 ! EMG1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008364 ! c2f-khdrbs1 physical interaction relationship: participates_in CCO:I0008451 ! c2f-nat6 physical interaction relationship: participates_in CCO:I0008818 ! c2f-psmb7 physical interaction relationship: participates_in CCO:I0008819 ! c2f-psme1 physical interaction relationship: transforms_into CCO:B0013158 ! NEP1_HUMAN-N-acetylalanine2 [Term] id: CCO:B0006268 name: ABCD4_HUMAN def: "ATP-binding cassette sub-family D member 4" [UniProtKB:O14678] synonym: "P70R" EXACT [UniProtKB:O14678] synonym: "Peroxisomal membrane protein 1-like" EXACT [UniProtKB:O14678] synonym: "Peroxisomal membrane protein 69" EXACT [UniProtKB:O14678] synonym: "PMP69" EXACT [UniProtKB:O14678] synonym: "PXMP1-L" EXACT [UniProtKB:O14678] xref: EMBL:AAB83967.1 xref: EMBL:AAH12815.1 xref: EMBL:AAP36080.1 xref: EMBL:CAA74699.1 xref: EMBL:CAG33385.1 xref: UniProtKB:O14678 xref: UniProtKB:Q6IAQ0 xref: UniProtKB:Q96E75 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004011 ! ABCD4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008381 ! dleu1-abcd4 physical interaction [Term] id: CCO:B0006270 name: ENOG_HUMAN def: "Gamma-enolase" [UniProtKB:P09104] synonym: "2-phospho-D-glycerate hydro-lyase" EXACT [UniProtKB:P09104] synonym: "EC 4.2.1.11" EXACT [UniProtKB:P09104] synonym: "Enolase 2" EXACT [UniProtKB:P09104] synonym: "Neural enolase" EXACT [UniProtKB:P09104] synonym: "Neuron-specific enolase" EXACT [UniProtKB:P09104] synonym: "NSE" EXACT [UniProtKB:P09104] xref: EMBL:AAA52388.1 xref: EMBL:AAB51320.1 xref: EMBL:AAB59554.1 xref: EMBL:AAH02745.1 xref: EMBL:AAP36047.1 xref: EMBL:CAA31512.1 xref: EMBL:CAA32505.1 xref: EMBL:CAA36215.1 xref: UniProtKB:P09104 xref: UniProtKB:Q96J33 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004566 ! ENO2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008386 ! eno2-ube2c physical interaction relationship: transforms_into CCO:B0011694 ! ENOG_HUMAN-Phosphotyrosine44 relationship: transforms_into CCO:B0011695 ! ENOG_HUMAN-Phosphoserine80 relationship: transforms_into CCO:B0031315 ! ENOG_HUMAN-Phosphotyrosine25 [Term] id: CCO:B0006272 name: GOGB1_HUMAN def: "Golgin subfamily B member 1" [UniProtKB:Q14789] synonym: "372 kDa Golgi complex-associated protein" EXACT [UniProtKB:Q14789] synonym: "GCP372" EXACT [UniProtKB:Q14789] synonym: "Giantin" EXACT [UniProtKB:Q14789] synonym: "Macrogolgin" EXACT [UniProtKB:Q14789] xref: EMBL:BAA05025.1 xref: EMBL:CAA53052.1 xref: UniProtKB:Q14398 xref: UniProtKB:Q14789 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004715 ! GOLGB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008391 ! golgb1-brms1 physical interaction [Term] id: CCO:B0006273 name: GPAA1_HUMAN def: "Glycosylphosphatidylinositol anchor attachment 1 protein" [UniProtKB:O43292] synonym: "GAA1 protein homolog" EXACT [UniProtKB:O43292] synonym: "GPI anchor attachment protein 1" EXACT [UniProtKB:O43292] synonym: "hGAA1" EXACT [UniProtKB:O43292] xref: EMBL:AAH03171.1 xref: EMBL:AAH04129.1 xref: EMBL:AAH06383.2 xref: EMBL:BAA24035.1 xref: EMBL:BAA82587.1 xref: EMBL:BAA82588.1 xref: EMBL:BAA82590.1 xref: EMBL:CAB75660.2 xref: UniProtKB:O43292 xref: UniProtKB:Q9NSS0 xref: UniProtKB:Q9UQ31 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004721 ! GPAA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008392 ! gpaa1-pin1 physical interaction [Term] id: CCO:B0006274 name: GOGA2_HUMAN def: "Golgin subfamily A member 2" [UniProtKB:Q08379] synonym: "Cis-Golgi matrix protein GM130" EXACT [UniProtKB:Q08379] synonym: "Gm130 autoantigen" EXACT [UniProtKB:Q08379] synonym: "Golgin-95" EXACT [UniProtKB:Q08379] xref: EMBL:AAA35920.1 xref: EMBL:AAF65550.1 xref: EMBL:AAH14188.2 xref: EMBL:AAH69268.1 xref: EMBL:AAP35912.1 xref: EMBL:CAI13841.1 xref: UniProtKB:Q08379 xref: UniProtKB:Q6GRM9 xref: UniProtKB:Q9BRB0 xref: UniProtKB:Q9NYF9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004714 ! GOLGA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008393 ! gps2-golga2 physical interaction relationship: transforms_into CCO:B0011954 ! GOGA2_HUMAN-Phosphoserine8 relationship: transforms_into CCO:B0011955 ! GOGA2_HUMAN-Phosphoserine25 relationship: transforms_into CCO:B0011956 ! GOGA2_HUMAN-Phosphoserine111 [Term] id: CCO:B0006275 name: HNRPL_HUMAN def: "Heterogeneous nuclear ribonucleoprotein L" [UniProtKB:P14866] synonym: "hnRNP L" EXACT [UniProtKB:P14866] xref: EMBL:BAB18649.1 xref: EMBL:CAA34261.1 xref: UniProtKB:P14866 xref: UniProtKB:Q9H3P3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006361 ! HNRNPL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008395 ! hmg20b-hnrpl physical interaction [Term] id: CCO:B0006276 name: TACC2_HUMAN def: "Transforming acidic coiled-coil-containing protein 2" [UniProtKB:O95359] synonym: "Anti Zuai-1" EXACT [UniProtKB:O95359] synonym: "AZU-1" EXACT [UniProtKB:O95359] xref: EMBL:AAC64968.2 xref: EMBL:AAF29537.2 xref: EMBL:AAF63433.1 xref: EMBL:AAH00999.1 xref: EMBL:AAH39311.1 xref: EMBL:AAO62629.1 xref: EMBL:AAO62630.1 xref: EMBL:CAD28509.1 xref: EMBL:CAI95127.1 xref: EMBL:CAI95128.1 xref: EMBL:CAI95131.1 xref: EMBL:CAI95134.1 xref: UniProtKB:O95359 xref: UniProtKB:Q4VXL0 xref: UniProtKB:Q4VXL3 xref: UniProtKB:Q4VXL6 xref: UniProtKB:Q4VXL7 xref: UniProtKB:Q5U5T7 xref: UniProtKB:Q86WG6 xref: UniProtKB:Q86WG7 xref: UniProtKB:Q8TCK9 xref: UniProtKB:Q9BVQ1 xref: UniProtKB:Q9NZ41 xref: UniProtKB:Q9NZR5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005722 ! TACC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008396 ! hmg20b-tacc2 physical interaction relationship: transforms_into CCO:B0014300 ! TACC2_HUMAN-Phosphoserine1946 relationship: transforms_into CCO:B0014301 ! TACC2_HUMAN-Phosphoserine1949 relationship: transforms_into CCO:B0014302 ! TACC2_HUMAN-Phosphoserine2256 relationship: transforms_into CCO:B0014303 ! TACC2_HUMAN-Phosphoserine2317 relationship: transforms_into CCO:B0014304 ! TACC2_HUMAN-Phosphoserine2512 [Term] id: CCO:B0006277 name: HNRH3_HUMAN def: "Heterogeneous nuclear ribonucleoprotein H3" [UniProtKB:P31942] synonym: "hnRNP 2H9" EXACT [UniProtKB:P31942] synonym: "hnRNP H3" EXACT [UniProtKB:P31942] xref: EMBL:AAD45179.1 xref: EMBL:AAF68843.1 xref: EMBL:AAF68844.1 xref: EMBL:AAF68845.1 xref: EMBL:AAF68846.1 xref: EMBL:AAF68847.1 xref: EMBL:AAF68848.1 xref: EMBL:AAF68849.1 xref: EMBL:AAF68850.1 xref: EMBL:AAF68851.1 xref: EMBL:AAF68852.1 xref: EMBL:AAH04511.2 xref: EMBL:AAH39824.1 xref: EMBL:CAB55897.1 xref: UniProtKB:P31942 xref: UniProtKB:Q9BSX1 xref: UniProtKB:Q9NP53 xref: UniProtKB:Q9NP96 xref: UniProtKB:Q9NPA7 xref: UniProtKB:Q9NPI4 xref: UniProtKB:Q9UFU4 xref: UniProtKB:Q9Y4J5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004816 ! HNRPH3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008397 ! hnrph3-pim2 physical interaction relationship: transforms_into CCO:B0012209 ! HNRH3_HUMAN-Asymmetric dimethylarginine121 relationship: transforms_into CCO:B0012210 ! HNRH3_HUMAN-Phosphoserine216 relationship: transforms_into CCO:B0012211 ! HNRH3_HUMAN-Phosphotyrosine296 [Term] id: CCO:B0006279 name: SYK_HUMAN def: "Lysyl-tRNA synthetase" [UniProtKB:Q15046] synonym: "EC 6.1.1.6" EXACT [UniProtKB:Q15046] synonym: "Lysine--tRNA ligase" EXACT [UniProtKB:Q15046] synonym: "LysRS" EXACT [UniProtKB:Q15046] xref: EMBL:AAH04132.1 xref: EMBL:BAA06688.1 xref: EMBL:BAA22084.1 xref: UniProtKB:O14946 xref: UniProtKB:Q15046 xref: UniProtKB:Q96J25 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005714 ! KARS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008400 ! kars-pafah1b1 physical interaction relationship: transforms_into CCO:B0014274 ! SYK_HUMAN-Phosphoserine596 relationship: transforms_into CCO:B0041343 ! SYK_HUMAN-N-acetylalanine2 [Term] id: CCO:B0006280 name: K0087_HUMAN def: "Uncharacterized protein KIAA0087" [UniProtKB:Q14695] xref: EMBL:BAA07639.2 xref: UniProtKB:Q14695 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004914 ! KIAA0087_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008401 ! kiaa0087-tp53 physical interaction relationship: transforms_into CCO:B0012451 ! K0087_HUMAN-Phosphoserine6 relationship: transforms_into CCO:B0012452 ! K0087_HUMAN-Phosphoserine7 [Term] id: CCO:B0006281 name: MLP3A_HUMAN def: "Microtubule-associated proteins 1A/1B light chain 3A precursor" [UniProtKB:Q9H492] synonym: "Autophagy-related protein LC3 A" EXACT [UniProtKB:Q9H492] synonym: "Autophagy-related ubiquitin-like modifier LC3 A" EXACT [UniProtKB:Q9H492] synonym: "MAP1 light chain 3-like protein 1" EXACT [UniProtKB:Q9H492] synonym: "MAP1A/1B light chain 3 A" EXACT [UniProtKB:Q9H492] synonym: "MAP1A/MAP1B LC3 A" EXACT [UniProtKB:Q9H492] synonym: "Microtubule-associated protein 1 light chain 3 alpha" EXACT [UniProtKB:Q9H492] xref: EMBL:AAH15810.1 xref: EMBL:AAK35151.1 xref: EMBL:AAP36120.1 xref: EMBL:CAC14078.1 xref: EMBL:CAD38714.1 xref: EMBL:CAI40290.1 xref: UniProtKB:Q9BXW5 xref: UniProtKB:Q9H492 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005102 ! MAP1LC3A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008403 ! kif15-map1lc3a physical interaction [Term] id: CCO:B0006283 name: TRP13_HUMAN def: "Thyroid receptor-interacting protein 13" [UniProtKB:Q15645] synonym: "16E1-BP" EXACT [UniProtKB:Q15645] synonym: "HPV16 E1 protein-binding protein" EXACT [UniProtKB:Q15645] synonym: "Human papillomavirus type 16 E1 protein-binding protein" EXACT [UniProtKB:Q15645] synonym: "Thyroid hormone receptor interactor 13" EXACT [UniProtKB:Q15645] synonym: "TRIP-13" EXACT [UniProtKB:Q15645] xref: EMBL:AAB64095.1 xref: EMBL:AAC41732.1 xref: EMBL:AAH00404.1 xref: EMBL:AAH19294.1 xref: EMBL:CAG33025.1 xref: UniProtKB:O15324 xref: UniProtKB:Q15645 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005836 ! TRIP13_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008405 ! mad2l1bp-trip13-1 physical interaction relationship: transforms_into CCO:B0014537 ! TRP13_HUMAN-Phosphotyrosine56 [Term] id: CCO:B0006285 name: GRIK5_HUMAN def: "Glutamate receptor, ionotropic kainate 5 precursor" [UniProtKB:Q16478] synonym: "EAA2" EXACT [UniProtKB:Q16478] synonym: "Excitatory amino acid receptor 2" EXACT [UniProtKB:Q16478] synonym: "Glutamate receptor KA-2" EXACT [UniProtKB:Q16478] synonym: "KA2" EXACT [UniProtKB:Q16478] xref: EMBL:AAB22591.1 xref: UniProtKB:Q16478 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004726 ! GRIK5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008407 ! mlf1-grik5 physical interaction [Term] id: CCO:B0006286 name: HPS6_HUMAN def: "Hermansky-Pudlak syndrome 6 protein" [UniProtKB:Q86YV9] synonym: "Ru" EXACT [UniProtKB:Q86YV9] synonym: "Ruby-eye protein homolog" EXACT [UniProtKB:Q86YV9] xref: EMBL:AAH11594.2 xref: EMBL:AAH14993.2 xref: EMBL:AAO25965.1 xref: EMBL:BAB15378.1 xref: UniProtKB:Q86YV9 xref: UniProtKB:Q9H685 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004827 ! HPS6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008408 ! mnat1-hps6 physical interaction [Term] id: CCO:B0006287 name: ERG28_HUMAN def: "Probable ergosterol biosynthetic protein 28" [UniProtKB:Q9UKR5] xref: EMBL:AAD51373.1 xref: EMBL:AAD54079.1 xref: EMBL:AAF28966.1 xref: EMBL:AAG49432.1 xref: EMBL:AAH02444.1 xref: EMBL:CAB66593.1 xref: UniProtKB:Q9P093 xref: UniProtKB:Q9UKR5 xref: UniProtKB:Q9UPI2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004583 ! C14orf1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008409 ! mphosph6-c14orf1 physical interaction [Term] id: CCO:B0006289 name: NDUB8_HUMAN def: "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor" [UniProtKB:O95169] synonym: "CI-ASHI" EXACT [UniProtKB:O95169] synonym: "Complex I-ASHI" EXACT [UniProtKB:O95169] synonym: "NADH-ubiquinone oxidoreductase ASHI subunit" EXACT [UniProtKB:O95169] xref: EMBL:AAD05422.1 xref: EMBL:AAD27761.1 xref: EMBL:AAH00466.1 xref: EMBL:AAH19276.1 xref: EMBL:AAP97239.1 xref: EMBL:CAB45691.1 xref: EMBL:CAB46274.1 xref: EMBL:CAG38521.1 xref: EMBL:CAH73563.1 xref: UniProtKB:O95169 xref: UniProtKB:Q5W144 xref: UniProtKB:Q9UG53 xref: UniProtKB:Q9UJR4 xref: UniProtKB:Q9UQF3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005170 ! NDUFB8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008412 ! ndufb8-pim2 physical interaction [Term] id: CCO:B0006291 name: PA1B2_HUMAN def: "Platelet-activating factor acetylhydrolase IB subunit beta" [UniProtKB:P68402] synonym: "EC 3.1.1.47" EXACT [UniProtKB:P68402] synonym: "PAF acetylhydrolase 30 kDa subunit" EXACT [UniProtKB:P68402] synonym: "PAF-AH 30 kDa subunit" EXACT [UniProtKB:P68402] synonym: "PAF-AH subunit beta" EXACT [UniProtKB:P68402] synonym: "PAFAH subunit beta" EXACT [UniProtKB:P68402] xref: EMBL:AAH00398.1 xref: EMBL:AAH19301.1 xref: EMBL:BAA19917.1 xref: UniProtKB:O00687 xref: UniProtKB:P68402 xref: UniProtKB:Q29459 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005250 ! PAFAH1B2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008414 ! pafah1b2-pinx1 physical interaction [Term] id: CCO:B0006293 name: Q53SQ6_HUMAN def: "Putative uncharacterized protein PTD004" [UniProtKB:Q53SQ6] xref: EMBL:AAY14876.1 xref: UniProtKB:Q53SQ6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005992 ! PTD004_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008421 ! ptd004-skb1 physical interaction [Term] id: CCO:B0006294 name: PTOV1_HUMAN def: "Prostate tumor overexpressed gene 1 protein" [UniProtKB:Q86YD1] synonym: "Activator interaction domain-containing protein 2" EXACT [UniProtKB:Q86YD1] synonym: "PTOV-1" EXACT [UniProtKB:Q86YD1] xref: EMBL:AAF70635.1 xref: EMBL:AAG17268.1 xref: EMBL:AAH15172.1 xref: EMBL:AAH42921.1 xref: EMBL:AAQ88535.1 xref: EMBL:CAE84582.1 xref: EMBL:EAW52558.1 xref: UniProtKB:Q6UXX7 xref: UniProtKB:Q86YD1 xref: UniProtKB:Q96BU3 xref: UniProtKB:Q9HBN4 xref: UniProtKB:Q9NYL1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005401 ! PTOV1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008423 ! ptov1-pin1 physical interaction [Term] id: CCO:B0006295 name: RAB4A_HUMAN def: "Ras-related protein Rab-4A" [UniProtKB:P20338] xref: EMBL:AAA60244.1 xref: EMBL:AAH02438.1 xref: EMBL:AAH04309.1 xref: EMBL:AAM21082.1 xref: UniProtKB:P20338 xref: UniProtKB:Q9BQ44 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005410 ! RAB4A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008424 ! rab4a-tp53 physical interaction relationship: transforms_into CCO:B0013657 ! RAB4A_HUMAN-Phosphoserine199 relationship: transforms_into CCO:B0013658 ! RAB4A_HUMAN-Cysteine methyl ester213 [Term] id: CCO:B0006296 name: WDR74_HUMAN def: "WD repeat-containing protein 74" [UniProtKB:Q6RFH5] synonym: "NOP seven-associated protein 1" EXACT [UniProtKB:Q6RFH5] xref: EMBL:AAH06351.1 xref: EMBL:AAS48499.1 xref: EMBL:BAA91610.1 xref: EMBL:BAB15122.1 xref: UniProtKB:Q6RFH5 xref: UniProtKB:Q9BRC9 xref: UniProtKB:Q9H6X8 xref: UniProtKB:Q9NVY2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005926 ! WDR74_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008427 ! rgs2-wdr74 physical interaction [Term] id: CCO:B0006297 name: Q8TBS9_HUMAN def: "LRFN1 protein" [UniProtKB:Q8TBS9] xref: EMBL:AAH25310.1 xref: UniProtKB:Q8TBS9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006031 ! LRFN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008428 ! rgs2-lrfn1 physical interaction [Term] id: CCO:B0006298 name: NIPS1_HUMAN def: "Protein NipSnap homolog 1" [UniProtKB:Q9BPW8] synonym: "NipSnap1" EXACT [UniProtKB:Q9BPW8] xref: EMBL:AAH02371.1 xref: EMBL:AAH06473.1 xref: EMBL:CAA04632.1 xref: UniProtKB:O43800 xref: UniProtKB:Q9BPW8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005197 ! NIPSNAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008429 ! rgs2-nipsnap1 physical interaction [Term] id: CCO:B0006299 name: VPS29_HUMAN def: "Vacuolar protein sorting-associated protein 29" [UniProtKB:Q9UBQ0] synonym: "EC 3.1.3.3" EXACT [UniProtKB:Q9UBQ0] synonym: "hVPS29" EXACT [UniProtKB:Q9UBQ0] synonym: "PEP11" EXACT [UniProtKB:Q9UBQ0] synonym: "Vesicle protein sorting 29" EXACT [UniProtKB:Q9UBQ0] xref: EMBL:AAF04596.1 xref: EMBL:AAF17238.1 xref: EMBL:AAF86872.1 xref: EMBL:AAF87318.1 xref: EMBL:AAF89952.1 xref: EMBL:AAH00880.1 xref: EMBL:AAH95446.1 xref: EMBL:CAB66549.1 xref: UniProtKB:Q502Y5 xref: UniProtKB:Q9H0W0 xref: UniProtKB:Q9NRP1 xref: UniProtKB:Q9NRU7 xref: UniProtKB:Q9UBQ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005905 ! VPS29_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008430 ! rgs2-vps29 physical interaction [Term] id: CCO:B0006302 name: DREB_HUMAN def: "Drebrin" [UniProtKB:Q16643] synonym: "Developmentally-regulated brain protein" EXACT [UniProtKB:Q16643] xref: EMBL:AAA16256.1 xref: EMBL:AAH00283.1 xref: EMBL:AAH07281.1 xref: EMBL:AAH07567.1 xref: EMBL:BAA04480.1 xref: EMBL:CAB53683.1 xref: UniProtKB:Q16643 xref: UniProtKB:Q9UFZ5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004512 ! DBN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008434 ! supt5h-dbn1 physical interaction relationship: participates_in CCO:I0008465 ! dbn1-nipbl physical interaction relationship: transforms_into CCO:B0011582 ! DREB_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0011583 ! DREB_HUMAN-Phosphoserine134 relationship: transforms_into CCO:B0011584 ! DREB_HUMAN-Phosphoserine141 relationship: transforms_into CCO:B0011585 ! DREB_HUMAN-Phosphoserine142 relationship: transforms_into CCO:B0011586 ! DREB_HUMAN-Phosphoserine337 relationship: transforms_into CCO:B0011587 ! DREB_HUMAN-Phosphoserine339 relationship: transforms_into CCO:B0011588 ! DREB_HUMAN-Phosphoserine342 relationship: transforms_into CCO:B0011589 ! DREB_HUMAN-Phosphothreonine346 relationship: transforms_into CCO:B0011590 ! DREB_HUMAN-Phosphotyrosine622 [Term] id: CCO:B0006304 name: THAP8_HUMAN def: "THAP domain-containing protein 8" [UniProtKB:Q8NA92] xref: EMBL:AAH72416.1 xref: EMBL:BAB71493.1 xref: EMBL:BAC04034.1 xref: UniProtKB:Q8NA92 xref: UniProtKB:Q96M21 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005778 ! THAP8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008440 ! thap8-tp53 physical interaction [Term] id: CCO:B0006305 name: UBP4_HUMAN def: "Ubiquitin carboxyl-terminal hydrolase 4" [UniProtKB:Q13107] synonym: "Deubiquitinating enzyme 4" EXACT [UniProtKB:Q13107] synonym: "EC 3.1.2.15" EXACT [UniProtKB:Q13107] synonym: "Ubiquitin thioesterase 4" EXACT [UniProtKB:Q13107] synonym: "Ubiquitin-specific-processing protease 4" EXACT [UniProtKB:Q13107] synonym: "Ubiquitous nuclear protein homolog" EXACT [UniProtKB:Q13107] xref: EMBL:AAB72237.1 xref: EMBL:AAC27355.1 xref: EMBL:AAC27356.1 xref: EMBL:AAI25131.1 xref: UniProtKB:O43452 xref: UniProtKB:O43453 xref: UniProtKB:Q08AK8 xref: UniProtKB:Q13107 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005869 ! USP4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008442 ! tp53bp2-usp4 physical interaction [Term] id: CCO:B0006306 name: GP135_HUMAN def: "Probable G-protein coupled receptor 135" [UniProtKB:Q8IZ08] xref: EMBL:AAH32831.2 xref: EMBL:AAO85100.1 xref: EMBL:AAP72127.1 xref: EMBL:BAC05800.1 xref: UniProtKB:Q7Z604 xref: UniProtKB:Q86SM3 xref: UniProtKB:Q8IZ08 xref: UniProtKB:Q8NH39 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004719 ! GPR135_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008443 ! tpd52l1-gpr135 physical interaction [Term] id: CCO:B0006309 name: TBL3_HUMAN def: "WD repeat-containing protein SAZD" [UniProtKB:Q12788] synonym: "Transducin beta-like 3 protein" EXACT [UniProtKB:Q12788] xref: EMBL:AAA18945.1 xref: UniProtKB:Q12788 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005743 ! TBL3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008448 ! aurkb-tbl3 physical interaction [Term] id: CCO:B0006310 name: SH3G1_HUMAN def: "Endophilin-A2" [UniProtKB:Q99961] synonym: "EEN" EXACT [UniProtKB:Q99961] synonym: "EEN fusion partner of MLL" EXACT [UniProtKB:Q99961] synonym: "Endophilin-2" EXACT [UniProtKB:Q99961] synonym: "Extra eleven-nineteen leukemia fusion gene protein" EXACT [UniProtKB:Q99961] synonym: "SH3 domain protein 2B" EXACT [UniProtKB:Q99961] synonym: "SH3 domain-containing GRB2-like protein 1" EXACT [UniProtKB:Q99961] xref: EMBL:AAB86800.1 xref: EMBL:AAF04290.1 xref: EMBL:AAH01270.1 xref: EMBL:CAA67970.1 xref: UniProtKB:Q99668 xref: UniProtKB:Q99961 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005607 ! SH3GL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008449 ! axin1-sh3gl1 physical interaction relationship: transforms_into CCO:B0014053 ! SH3G1_HUMAN-Phosphoserine288 [Term] id: CCO:B0006311 name: BRD4_HUMAN def: "Bromodomain-containing protein 4" [UniProtKB:O60885] synonym: "HUNK1 protein" EXACT [UniProtKB:O60885] xref: EMBL:AAC27978.1 xref: EMBL:AAL26987.1 xref: EMBL:AAO22237.1 xref: EMBL:CAA72780.1 xref: UniProtKB:O60433 xref: UniProtKB:O60885 xref: UniProtKB:Q86YS8 xref: UniProtKB:Q96PD3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004188 ! BRD4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008450 ! brd4-chfr physical interaction relationship: transforms_into CCO:B0010861 ! BRD4_HUMAN-Phosphoserine470 relationship: transforms_into CCO:B0010862 ! BRD4_HUMAN-Phosphoserine601 relationship: transforms_into CCO:B0010863 ! BRD4_HUMAN-Phosphoserine1045 relationship: transforms_into CCO:B0010864 ! BRD4_HUMAN-Phosphoserine1117 [Term] id: CCO:B0006312 name: URM1_HUMAN def: "Ubiquitin-related modifier 1 homolog" [UniProtKB:Q9BTM9] xref: EMBL:AAH03581.1 xref: EMBL:CAI13493.1 xref: UniProtKB:Q9BTM9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005886 ! URM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008453 ! cdc2l1-c9orf74 physical interaction [Term] id: CCO:B0006313 name: SRPRB_HUMAN def: "Signal recognition particle receptor subunit beta" [UniProtKB:Q9Y5M8] synonym: "Protein APMCF1" EXACT [UniProtKB:Q9Y5M8] synonym: "SR-beta" EXACT [UniProtKB:Q9Y5M8] xref: EMBL:AAD34888.3 xref: EMBL:AAH65299.1 xref: EMBL:BAB55176.1 xref: EMBL:BAC11675.1 xref: UniProtKB:Q8N2D8 xref: UniProtKB:Q9Y5M8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005672 ! SRPRB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008455 ! cdk5rap3-srprb physical interaction [Term] id: CCO:B0006314 name: CA123_HUMAN def: "Uncharacterized protein C1orf123" [UniProtKB:Q9NWV4] xref: EMBL:AAH10908.1 xref: EMBL:BAA91272.1 xref: EMBL:CAG33527.1 xref: EMBL:CAI18911.1 xref: UniProtKB:Q9NWV4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004201 ! C1orf123_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008456 ! cdkn1a-flj20580 physical interaction [Term] id: CCO:B0006315 name: NRK2_HUMAN def: "Nicotinamide riboside kinase 2" [UniProtKB:Q9NPI5] synonym: "EC 2.7.1.-" EXACT [UniProtKB:Q9NPI5] synonym: "Integrin beta-1-binding protein 3" EXACT [UniProtKB:Q9NPI5] synonym: "MIBP" EXACT [UniProtKB:Q9NPI5] synonym: "Muscle integrin-binding protein" EXACT [UniProtKB:Q9NPI5] xref: EMBL:AAF26711.1 xref: EMBL:AAH93637.1 xref: EMBL:AAI01576.1 xref: EMBL:AAT11929.1 xref: EMBL:BAA91820.1 xref: EMBL:BAB14071.1 xref: EMBL:CAB96949.1 xref: UniProtKB:Q52M81 xref: UniProtKB:Q9NPI5 xref: UniProtKB:Q9NZK3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005213 ! ITGB1BP3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008457 ! cdkn1a-itgb1bp3 physical interaction [Term] id: CCO:B0006316 name: M2OM_HUMAN def: "Mitochondrial 2-oxoglutarate/malate carrier protein" [UniProtKB:Q02978] synonym: "OGCP" EXACT [UniProtKB:Q02978] synonym: "Solute carrier family 25 member 11" EXACT [UniProtKB:Q02978] xref: EMBL:AAC28637.1 xref: EMBL:AAH06508.1 xref: EMBL:AAH06519.1 xref: EMBL:AAH16294.1 xref: EMBL:AAH17170.1 xref: EMBL:CAA46905.1 xref: UniProtKB:O75537 xref: UniProtKB:Q02978 xref: UniProtKB:Q969P7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005003 ! SLC25A11_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008458 ! cdkn1a-slc25a11 physical interaction relationship: transforms_into CCO:B0012714 ! M2OM_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0031338 ! M2OM_HUMAN-Phosphotyrosine102 relationship: transforms_into CCO:B0031339 ! M2OM_HUMAN-Phosphotyrosine202 [Term] id: CCO:B0006317 name: GABR1_HUMAN def: "Gamma-aminobutyric acid type B receptor subunit 1 precursor" [UniProtKB:Q9UBS5] synonym: "GABA-B receptor 1" EXACT [UniProtKB:Q9UBS5] synonym: "GABA-B-R1" EXACT [UniProtKB:Q9UBS5] synonym: "Gb1" EXACT [UniProtKB:Q9UBS5] xref: EMBL:AAC98508.1 xref: EMBL:AAH42598.1 xref: EMBL:AAH50532.2 xref: EMBL:CAA09031.1 xref: EMBL:CAA09939.1 xref: EMBL:CAA09940.1 xref: EMBL:CAA09941.1 xref: EMBL:CAA09980.1 xref: EMBL:CAA12359.1 xref: EMBL:CAA12360.1 xref: EMBL:CAA21453.1 xref: EMBL:CAA21454.1 xref: UniProtKB:O95375 xref: UniProtKB:O95468 xref: UniProtKB:O95975 xref: UniProtKB:O96022 xref: UniProtKB:Q86W60 xref: UniProtKB:Q9UBS5 xref: UniProtKB:Q9UQQ0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004680 ! GABBR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008459 ! chfr-gabbr1 physical interaction relationship: transforms_into CCO:B0011919 ! GABR1_HUMAN-Phosphothreonine930 [Term] id: CCO:B0006318 name: ITAE_HUMAN def: "Integrin alpha-E precursor" [UniProtKB:P38570] synonym: "CD103 antigen" EXACT [UniProtKB:P38570] synonym: "HML-1 antigen" EXACT [UniProtKB:P38570] synonym: "Integrin alpha-IEL" EXACT [UniProtKB:P38570] synonym: "Mucosal lymphocyte 1 antigen" EXACT [UniProtKB:P38570] xref: EMBL:AAB59359.2 xref: EMBL:AAF43107.1 xref: EMBL:AAI13437.1 xref: EMBL:AAI17208.1 xref: UniProtKB:P38570 xref: UniProtKB:Q17RS6 xref: UniProtKB:Q9NZU9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004904 ! ITGAE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008460 ! chfr-itgae physical interaction [Term] id: CCO:B0006319 name: WDR47_HUMAN def: "WD repeat-containing protein 47" [UniProtKB:O94967] xref: EMBL:AAH34964.1 xref: EMBL:AAH39254.1 xref: EMBL:BAA74916.2 xref: UniProtKB:O94967 xref: UniProtKB:Q8IXT7 xref: UniProtKB:Q8IYU9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005920 ! WDR47_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008461 ! chfr-wdr47 physical interaction [Term] id: CCO:B0006320 name: CHSS2_HUMAN def: "Chondroitin sulfate synthase 2" [UniProtKB:Q8IZ52] synonym: "Chondroitin glucuronyltransferase II" EXACT [UniProtKB:Q8IZ52] synonym: "Chondroitin-polymerizing factor" EXACT [UniProtKB:Q8IZ52] synonym: "EC 2.4.1.175" EXACT [UniProtKB:Q8IZ52] synonym: "EC 2.4.1.226" EXACT [UniProtKB:Q8IZ52] synonym: "Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II" EXACT [UniProtKB:Q8IZ52] synonym: "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II" EXACT [UniProtKB:Q8IZ52] synonym: "N-acetylgalactosaminyltransferase" EXACT [UniProtKB:Q8IZ52] xref: EMBL:AAH08878.2 xref: EMBL:AAH21223.2 xref: EMBL:AAH23531.1 xref: EMBL:AAQ88769.1 xref: EMBL:BAB15449.1 xref: EMBL:BAC78393.1 xref: EMBL:BAC81536.1 xref: EMBL:CAB66748.2 xref: UniProtKB:Q6UXD6 xref: UniProtKB:Q7L4G1 xref: UniProtKB:Q8IZ52 xref: UniProtKB:Q9H0F8 xref: UniProtKB:Q9H618 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0013372 ! CHPF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008462 ! css2-pin1 physical interaction relationship: transforms_into CCO:B0011218 ! CHSS2_HUMAN-Phosphoserine126 relationship: transforms_into CCO:B0011219 ! CHSS2_HUMAN-Phosphothreonine129 [Term] id: CCO:B0006321 name: MTFR1_HUMAN def: "Mitochondrial fission regulator 1" [UniProtKB:Q15390] synonym: "Chondrocyte protein with a poly-proline region" EXACT [UniProtKB:Q15390] xref: EMBL:AAH36116.1 xref: EMBL:AAH43498.1 xref: EMBL:BAA02798.1 xref: EMBL:CAG33191.1 xref: UniProtKB:Q15390 xref: UniProtKB:Q6IB94 xref: UniProtKB:Q86XH5 xref: UniProtKB:Q8IVD7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005132 ! MTFR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008463 ! mtfr1-pin1 physical interaction relationship: transforms_into CCO:B0013030 ! MTFR1_HUMAN-Phosphotyrosine30 relationship: transforms_into CCO:B0013031 ! MTFR1_HUMAN-Phosphoserine32 relationship: transforms_into CCO:B0013032 ! MTFR1_HUMAN-Phosphoserine33 relationship: transforms_into CCO:B0013033 ! MTFR1_HUMAN-Phosphoserine119 relationship: transforms_into CCO:B0013034 ! MTFR1_HUMAN-Phosphoserine290 [Term] id: CCO:B0006323 name: PGAM1_HUMAN def: "Phosphoglycerate mutase 1" [UniProtKB:P18669] synonym: "BPG-dependent PGAM 1" EXACT [UniProtKB:P18669] synonym: "EC 3.1.3.13" EXACT [UniProtKB:P18669] synonym: "EC 5.4.2.1" EXACT [UniProtKB:P18669] synonym: "EC 5.4.2.4" EXACT [UniProtKB:P18669] synonym: "PGAM-B" EXACT [UniProtKB:P18669] synonym: "Phosphoglycerate mutase isozyme B" EXACT [UniProtKB:P18669] xref: EMBL:AAA60071.1 xref: EMBL:AAG01990.1 xref: EMBL:AAH10038.1 xref: EMBL:AAH11678.1 xref: EMBL:AAH53356.1 xref: EMBL:AAH66959.1 xref: EMBL:AAH73742.1 xref: UniProtKB:P18669 xref: UniProtKB:Q9BWC0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005302 ! PGAM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008466 ! dctn1-pgam1 physical interaction relationship: transforms_into CCO:B0013494 ! PGAM1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0013495 ! PGAM1_HUMAN-Phosphoserine14 relationship: transforms_into CCO:B0013496 ! PGAM1_HUMAN-Phosphotyrosine26 relationship: transforms_into CCO:B0013497 ! PGAM1_HUMAN-Phosphoserine118 [Term] id: CCO:B0006324 name: ARL8B_HUMAN def: "ADP-ribosylation factor-like protein 8B" [UniProtKB:Q9NVJ2] synonym: "ADP-ribosylation factor-like protein 10C" EXACT [UniProtKB:Q9NVJ2] synonym: "Novel small G protein indispensable for equal chromosome segregation 1" EXACT [UniProtKB:Q9NVJ2] xref: EMBL:AAH13131.1 xref: EMBL:AAH63125.1 xref: EMBL:BAA91759.1 xref: EMBL:BAD23992.1 xref: EMBL:CAG33545.1 xref: UniProtKB:Q9NVJ2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004097 ! ARL8B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008467 ! dleu1-arl10c physical interaction relationship: transforms_into CCO:B0010603 ! ARL8B_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0006326 name: PEF1_HUMAN def: "Peflin" [UniProtKB:Q9UBV8] synonym: "PEF protein with a long N-terminal hydrophobic domain" EXACT [UniProtKB:Q9UBV8] synonym: "Penta-EF hand domain-containing protein 1" EXACT [UniProtKB:Q9UBV8] xref: EMBL:AAH02773.1 xref: EMBL:AAH12561.1 xref: EMBL:AAQ89370.1 xref: EMBL:BAA84922.1 xref: EMBL:BAA85163.1 xref: EMBL:BAA91680.1 xref: EMBL:CAG46936.1 xref: UniProtKB:Q9UBV8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005297 ! PEF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008471 ! dnm2-pef1 physical interaction [Term] id: CCO:B0006327 name: PPIB_HUMAN def: "Peptidyl-prolyl cis-trans isomerase B precursor" [UniProtKB:P23284] synonym: "Cyclophilin B" EXACT [UniProtKB:P23284] synonym: "CYP-S1" EXACT [UniProtKB:P23284] synonym: "EC 5.2.1.8" EXACT [UniProtKB:P23284] synonym: "PPIase" EXACT [UniProtKB:P23284] synonym: "Rotamase" EXACT [UniProtKB:P23284] synonym: "S-cyclophilin" EXACT [UniProtKB:P23284] synonym: "SCYLP" EXACT [UniProtKB:P23284] xref: EMBL:AAA35733.1 xref: EMBL:AAA36601.1 xref: EMBL:AAA52150.1 xref: EMBL:AAH01125.1 xref: EMBL:AAH08848.1 xref: EMBL:AAH20800.1 xref: EMBL:AAH32138.1 xref: EMBL:AAX44050.1 xref: UniProtKB:P23284 xref: UniProtKB:Q9BVK5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005365 ! PPIB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008472 ! dnm2-ppib physical interaction [Term] id: CCO:B0006328 name: FBX18_HUMAN def: "F-box only protein 18" [UniProtKB:Q8NFZ0] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q8NFZ0] synonym: "F-box DNA helicase 1" EXACT [UniProtKB:Q8NFZ0] xref: EMBL:AAH12762.2 xref: EMBL:AAH32674.2 xref: EMBL:AAI13378.1 xref: EMBL:AAM73631.1 xref: EMBL:AAP97700.1 xref: EMBL:AAP97705.1 xref: EMBL:BAB55073.1 xref: EMBL:BAB55154.1 xref: EMBL:BAC04535.1 xref: EMBL:CAB61392.1 xref: EMBL:CAI41073.1 xref: UniProtKB:Q5JVB1 xref: UniProtKB:Q7Z4Q6 xref: UniProtKB:Q7Z4R0 xref: UniProtKB:Q8N1P5 xref: UniProtKB:Q8N586 xref: UniProtKB:Q8NFZ0 xref: UniProtKB:Q96E82 xref: UniProtKB:Q96K67 xref: UniProtKB:Q96SW7 xref: UniProtKB:Q9UFB2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004622 ! FBXO18_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008473 ! fbxo18-pim2 physical interaction [Term] id: CCO:B0006329 name: ANKZ1_HUMAN def: "Ankyrin repeat and zinc finger domain-containing protein 1" [UniProtKB:Q9H8Y5] synonym: "Zinc finger protein 744" EXACT [UniProtKB:Q9H8Y5] xref: EMBL:AAH00238.1 xref: EMBL:AAH08948.1 xref: EMBL:ABD65410.1 xref: EMBL:BAA91596.1 xref: EMBL:BAB14462.1 xref: UniProtKB:Q9H8Y5 xref: UniProtKB:Q9NVZ4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004061 ! ANKZF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008474 ! flj10415-aurkb physical interaction relationship: transforms_into CCO:B0010533 ! ANKZ1_HUMAN-Phosphoserine258 relationship: transforms_into CCO:B0010534 ! ANKZ1_HUMAN-Phosphoserine361 relationship: transforms_into CCO:B0010535 ! ANKZ1_HUMAN-Phosphoserine398 relationship: transforms_into CCO:B0010536 ! ANKZ1_HUMAN-Phosphothreonine607 [Term] id: CCO:B0006330 name: CG025_HUMAN def: "UPF0415 protein C7orf25" [UniProtKB:Q9BPX7] xref: EMBL:AAH00769.1 xref: EMBL:AAH01845.1 xref: EMBL:BAB15019.1 xref: UniProtKB:Q9BPX7 xref: UniProtKB:Q9H779 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004337 ! C7orf25_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008476 ! fzr1-c7orf25 physical interaction relationship: transforms_into CCO:B0011193 ! CG025_HUMAN-Phosphoserine208 relationship: transforms_into CCO:B0011194 ! CG025_HUMAN-Phosphoserine210 relationship: transforms_into CCO:B0011195 ! CG025_HUMAN-Phosphoserine212 [Term] id: CCO:B0006332 name: INPP_HUMAN def: "Inositol polyphosphate 1-phosphatase" [UniProtKB:P49441] synonym: "EC 3.1.3.57" EXACT [UniProtKB:P49441] synonym: "IPP" EXACT [UniProtKB:P49441] synonym: "IPPase" EXACT [UniProtKB:P49441] xref: EMBL:AAA36117.1 xref: EMBL:AAD46766.1 xref: EMBL:AAH15496.1 xref: UniProtKB:P49441 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004899 ! INPP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008480 ! inpp1-lig1 physical interaction [Term] id: CCO:B0006333 name: TTLL5_HUMAN def: "Tubulin polyglutamylase TTLL5" [UniProtKB:Q6EMB2] synonym: "EC 6.-.-.-" EXACT [UniProtKB:Q6EMB2] synonym: "SRC1 and TIF2-associated modulatory protein" EXACT [UniProtKB:Q6EMB2] synonym: "Tubulin--tyrosine ligase-like protein 5" EXACT [UniProtKB:Q6EMB2] xref: EMBL:AAF23275.2 xref: EMBL:AAP75557.1 xref: EMBL:BAA76842.1 xref: UniProtKB:Q6EMB2 xref: UniProtKB:Q9P1V5 xref: UniProtKB:Q9UPZ4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005843 ! TTLL5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008481 ! kiaa0998-cdkn1a physical interaction relationship: transforms_into CCO:B0014555 ! TTLL5_HUMAN-Phosphothreonine515 [Term] id: CCO:B0006334 name: AMRP_HUMAN def: "Alpha-2-macroglobulin receptor-associated protein precursor" [UniProtKB:P30533] synonym: "Alpha-2-MRAP" EXACT [UniProtKB:P30533] synonym: "Low density lipoprotein receptor-related protein-associated protein 1" EXACT [UniProtKB:P30533] synonym: "RAP" EXACT [UniProtKB:P30533] xref: EMBL:AAA51553.1 xref: EMBL:AAA87889.1 xref: EMBL:AAC67373.1 xref: EMBL:AAI05075.1 xref: EMBL:AAI12068.1 xref: EMBL:BAD96224.1 xref: EMBL:BAD96247.1 xref: EMBL:CAM21451.1 xref: UniProtKB:P30533 xref: UniProtKB:Q2M310 xref: UniProtKB:Q53HQ3 xref: UniProtKB:Q53HS6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004051 ! LRPAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008482 ! lrpap1-ppm1g physical interaction [Term] id: CCO:B0006335 name: LRSM1_HUMAN def: "E3 ubiquitin-protein ligase LRSAM1" [UniProtKB:Q6UWE0] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q6UWE0] synonym: "hTAL" EXACT [UniProtKB:Q6UWE0] synonym: "Leucine-rich repeat and sterile alpha motif-containing protein 1" EXACT [UniProtKB:Q6UWE0] synonym: "Tsg101-associated ligase" EXACT [UniProtKB:Q6UWE0] xref: EMBL:AAH09239.1 xref: EMBL:AAQ89189.1 xref: EMBL:BAB71119.1 xref: EMBL:BAB71144.1 xref: EMBL:BAC03703.1 xref: EMBL:CAH72930.1 xref: EMBL:CAH72931.1 xref: UniProtKB:Q5VVV0 xref: UniProtKB:Q6UWE0 xref: UniProtKB:Q8NB40 xref: UniProtKB:Q96GT5 xref: UniProtKB:Q96MX5 xref: UniProtKB:Q96MZ7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004989 ! LRSAM1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008483 ! lrsam1-mutyh physical interaction [Term] id: CCO:B0006336 name: NOL12_HUMAN def: "Nucleolar protein 12" [UniProtKB:Q9UGY1] xref: EMBL:AAH02808.1 xref: EMBL:CAB63039.1 xref: EMBL:CAB77148.1 xref: EMBL:CAG30349.1 xref: UniProtKB:Q9UGY1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005204 ! NOL12_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008484 ! mgc3731-cdk4 physical interaction relationship: transforms_into CCO:B0013204 ! NOL12_HUMAN-Phosphothreonine124 relationship: transforms_into CCO:B0013205 ! NOL12_HUMAN-Phosphoserine139 relationship: transforms_into CCO:B0013206 ! NOL12_HUMAN-Phosphoserine140 relationship: transforms_into CCO:B0013207 ! NOL12_HUMAN-Phosphothreonine141 [Term] id: CCO:B0006337 name: MYP0_HUMAN def: "Myelin P0 protein precursor" [UniProtKB:P25189] synonym: "MPP" EXACT [UniProtKB:P25189] synonym: "Myelin peripheral protein" EXACT [UniProtKB:P25189] synonym: "Myelin protein zero" EXACT [UniProtKB:P25189] xref: EMBL:AAA18981.1 xref: EMBL:AAA20656.1 xref: EMBL:AAB28708.1 xref: EMBL:AAH06491.1 xref: EMBL:AAP35411.1 xref: EMBL:BAA01395.1 xref: EMBL:BAA03540.1 xref: UniProtKB:P25189 xref: UniProtKB:Q16072 xref: UniProtKB:Q92677 xref: UniProtKB:Q9BR67 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005150 ! MPZ_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008485 ! mpz-pinx1 physical interaction relationship: transforms_into CCO:B0013070 ! MYP0_HUMAN-Phosphoserine226 relationship: transforms_into CCO:B0013071 ! MYP0_HUMAN-Phosphoserine228 relationship: transforms_into CCO:B0013072 ! MYP0_HUMAN-Phosphoserine233 relationship: transforms_into CCO:B0013073 ! MYP0_HUMAN-Phosphoserine243 [Term] id: CCO:B0006339 name: DEF1_HUMAN def: "Neutrophil defensin 1 precursor" [UniProtKB:P59665] synonym: "Defensin, alpha 1" EXACT [UniProtKB:P59665] synonym: "HNP-1" EXACT [UniProtKB:P59665] synonym: "HP-1" EXACT [UniProtKB:P59665] synonym: "HP1" EXACT [UniProtKB:P59665] xref: EMBL:AAA36382.1 xref: EMBL:AAA52302.1 xref: EMBL:AAA52303.1 xref: EMBL:AAH69423.1 xref: EMBL:CAA36280.1 xref: UniProtKB:P11479 xref: UniProtKB:P59665 xref: UniProtKB:Q14125 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004462 ! DEFA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008488 ! pfdn1-defa1 physical interaction [Term] id: CCO:B0006341 name: PO3F3_HUMAN def: "POU domain, class 3, transcription factor 3" [UniProtKB:P20264] synonym: "Brain-1" EXACT [UniProtKB:P20264] synonym: "Brain-specific homeobox/POU domain protein 1" EXACT [UniProtKB:P20264] synonym: "Brn-1 protein" EXACT [UniProtKB:P20264] xref: EMBL:BAA19459.1 xref: UniProtKB:P20264 xref: UniProtKB:P78379 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005353 ! POU3F3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008490 ! pou3f3-ppp1r15a physical interaction [Term] id: CCO:B0006342 name: MLP3B_HUMAN def: "Microtubule-associated proteins 1A/1B light chain 3B precursor" [UniProtKB:Q9GZQ8] synonym: "Autophagy-related protein LC3 B" EXACT [UniProtKB:Q9GZQ8] synonym: "Autophagy-related ubiquitin-like modifier LC3 B" EXACT [UniProtKB:Q9GZQ8] synonym: "MAP1 light chain 3-like protein 2" EXACT [UniProtKB:Q9GZQ8] synonym: "MAP1A/1B light chain 3 B" EXACT [UniProtKB:Q9GZQ8] synonym: "MAP1A/MAP1B LC3 B" EXACT [UniProtKB:Q9GZQ8] synonym: "Microtubule-associated protein 1 light chain 3 beta" EXACT [UniProtKB:Q9GZQ8] xref: EMBL:AAG09686.1 xref: EMBL:AAG23182.1 xref: EMBL:AAH18634.1 xref: EMBL:AAH41874.1 xref: EMBL:AAH67797.1 xref: EMBL:AAM10499.1 xref: EMBL:BAB15169.1 xref: UniProtKB:Q6NW02 xref: UniProtKB:Q9GZQ8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005103 ! MAP1LC3B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008493 ! rad1-map1lc3b physical interaction [Term] id: CCO:B0006343 name: NFL_HUMAN def: "Neurofilament light polypeptide" [UniProtKB:P07196] synonym: "68 kDa neurofilament protein" EXACT [UniProtKB:P07196] synonym: "Neurofilament triplet L protein" EXACT [UniProtKB:P07196] synonym: "NF-L" EXACT [UniProtKB:P07196] xref: EMBL:AAD14057.1 xref: EMBL:AAH39237.1 xref: EMBL:AAN74826.1 xref: EMBL:CAA29097.1 xref: UniProtKB:P07196 xref: UniProtKB:Q16154 xref: UniProtKB:Q8IU72 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005188 ! NEFL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008494 ! ran-nefl physical interaction relationship: transforms_into CCO:B0013169 ! NFL_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0013170 ! NFL_HUMAN-Phosphoserine56 relationship: transforms_into CCO:B0013171 ! NFL_HUMAN-Phosphoserine67 relationship: transforms_into CCO:B0013172 ! NFL_HUMAN-Phosphoserine472 relationship: transforms_into CCO:B0031358 ! NFL_HUMAN-Phosphotyrosine43 relationship: transforms_into CCO:B0031359 ! NFL_HUMAN-Phosphotyrosine424 relationship: transforms_into CCO:B0031360 ! NFL_HUMAN-Phosphotyrosine432 [Term] id: CCO:B0006344 name: NUD10_HUMAN def: "Diphosphoinositol polyphosphate phosphohydrolase 3 alpha" [UniProtKB:Q8NFP7] synonym: "Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3 alpha" EXACT [UniProtKB:Q8NFP7] synonym: "DIPP-3 alpha" EXACT [UniProtKB:Q8NFP7] synonym: "DIPP3 alpha" EXACT [UniProtKB:Q8NFP7] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q8NFP7] synonym: "EC 3.6.1.52" EXACT [UniProtKB:Q8NFP7] synonym: "hAps2" EXACT [UniProtKB:Q8NFP7] synonym: "hDIPP3alpha" EXACT [UniProtKB:Q8NFP7] synonym: "Nucleoside diphosphate-linked moiety X motif 10" EXACT [UniProtKB:Q8NFP7] synonym: "Nudix motif 10" EXACT [UniProtKB:Q8NFP7] xref: EMBL:AAH49383.1 xref: EMBL:AAH50700.1 xref: EMBL:AAM64113.1 xref: EMBL:CAI40295.1 xref: UniProtKB:Q86VK1 xref: UniProtKB:Q86VR0 xref: UniProtKB:Q8NFP7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005221 ! NUDT10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008495 ! rassf1-nudt10 physical interaction [Term] id: CCO:B0006345 name: CATB_HUMAN def: "Cathepsin B precursor" [UniProtKB:P07858] synonym: "APP secretase" EXACT [UniProtKB:P07858] synonym: "APPS" EXACT [UniProtKB:P07858] synonym: "Cathepsin B1" EXACT [UniProtKB:P07858] synonym: "EC 3.4.22.1" EXACT [UniProtKB:P07858] xref: EMBL:AAA52125.1 xref: EMBL:AAA52129.1 xref: EMBL:AAC37547.1 xref: EMBL:AAH10240.1 xref: EMBL:AAH95408.1 xref: UniProtKB:P07858 xref: UniProtKB:Q503A6 xref: UniProtKB:Q96D87 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004223 ! CTSB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008496 ! rgs2-ctsb physical interaction [Term] id: CCO:B0006346 name: SCN5A_HUMAN def: "Sodium channel protein type 5 subunit alpha" [UniProtKB:Q14524] synonym: "HH1" EXACT [UniProtKB:Q14524] synonym: "Sodium channel protein cardiac muscle subunit alpha" EXACT [UniProtKB:Q14524] synonym: "Sodium channel protein type V subunit alpha" EXACT [UniProtKB:Q14524] synonym: "Voltage-gated sodium channel subunit alpha Nav1.5" EXACT [UniProtKB:Q14524] xref: EMBL:AAA58644.1 xref: UniProtKB:Q14524 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005573 ! SCN5A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008497 ! rgs2-scn5a physical interaction [Term] id: CCO:B0006347 name: XPP1_HUMAN def: "Xaa-Pro aminopeptidase 1" [UniProtKB:Q9NQW7] synonym: "Aminoacylproline aminopeptidase" EXACT [UniProtKB:Q9NQW7] synonym: "Cytosolic aminopeptidase P" EXACT [UniProtKB:Q9NQW7] synonym: "EC 3.4.11.9" EXACT [UniProtKB:Q9NQW7] synonym: "sAmp" EXACT [UniProtKB:Q9NQW7] synonym: "Soluble aminopeptidase P" EXACT [UniProtKB:Q9NQW7] synonym: "X-Pro aminopeptidase 1" EXACT [UniProtKB:Q9NQW7] synonym: "X-prolyl aminopeptidase 1, soluble" EXACT [UniProtKB:Q9NQW7] xref: EMBL:AAF75795.1 xref: EMBL:AAF97866.1 xref: EMBL:AAH05126.1 xref: EMBL:AAH07579.1 xref: EMBL:AAH13417.4 xref: EMBL:BAD97233.1 xref: EMBL:CAA65068.1 xref: EMBL:CAD38640.1 xref: EMBL:CAG33203.1 xref: EMBL:CAI14248.1 xref: UniProtKB:O15250 xref: UniProtKB:Q53EX6 xref: UniProtKB:Q8N3Q0 xref: UniProtKB:Q96D23 xref: UniProtKB:Q9NQW7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005944 ! XPNPEP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008500 ! rint1-xpnpep1 physical interaction [Term] id: CCO:B0006349 name: SCFD1_HUMAN def: "Sec1 family domain-containing protein 1" [UniProtKB:Q8WVM8] synonym: "Sly1p" EXACT [UniProtKB:Q8WVM8] synonym: "Syntaxin-binding protein 1-like 2" EXACT [UniProtKB:Q8WVM8] xref: EMBL:AAC17907.1 xref: EMBL:AAD40381.1 xref: EMBL:AAD48586.1 xref: EMBL:AAG50273.1 xref: EMBL:AAH17734.1 xref: EMBL:AAP97146.1 xref: EMBL:BAA74940.2 xref: UniProtKB:O60754 xref: UniProtKB:O94990 xref: UniProtKB:Q7Z529 xref: UniProtKB:Q8WVM8 xref: UniProtKB:Q9BZI3 xref: UniProtKB:Q9UNL3 xref: UniProtKB:Q9Y6A8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005571 ! SCFD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008817 ! usp22-scfd1 physical interaction relationship: transforms_into CCO:B0013966 ! SCFD1_HUMAN-Phosphoserine57 relationship: transforms_into CCO:B0013967 ! SCFD1_HUMAN-Phosphoserine528 [Term] id: CCO:B0006350 name: VAMP8_HUMAN def: "Vesicle-associated membrane protein 8" [UniProtKB:Q9BV40] synonym: "EDB" EXACT [UniProtKB:Q9BV40] synonym: "Endobrevin" EXACT [UniProtKB:Q9BV40] synonym: "VAMP-8" EXACT [UniProtKB:Q9BV40] xref: EMBL:AAC08434.1 xref: EMBL:AAH01634.1 xref: EMBL:AAP35346.1 xref: EMBL:AAY24341.1 xref: EMBL:CAG33276.1 xref: UniProtKB:O60625 xref: UniProtKB:Q53SP9 xref: UniProtKB:Q6IB09 xref: UniProtKB:Q9BV40 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005892 ! VAMP8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008504 ! pnn-vamp8 physical interaction [Term] id: CCO:B0006351 name: WBP2_HUMAN def: "WW domain-binding protein 2" [UniProtKB:Q969T9] synonym: "WBP-2" EXACT [UniProtKB:Q969T9] xref: EMBL:AAD10951.1 xref: EMBL:AAH07452.1 xref: EMBL:AAH10616.1 xref: UniProtKB:O95638 xref: UniProtKB:Q969T9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005914 ! WBP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008505 ! sept3-wbp2 physical interaction relationship: transforms_into CCO:B0014668 ! WBP2_HUMAN-Phosphotyrosine232 [Term] id: CCO:B0006352 name: STRN4_HUMAN def: "Striatin-4" [UniProtKB:Q9NRL3] synonym: "Zinedin" EXACT [UniProtKB:Q9NRL3] xref: EMBL:AAF29527.1 xref: EMBL:AAH04910.2 xref: EMBL:AAH34604.1 xref: UniProtKB:Q8NE53 xref: UniProtKB:Q9NRL3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005699 ! STRN4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008552 ! strn4-asns physical interaction relationship: transforms_into CCO:B0014269 ! STRN4_HUMAN-Phosphoserine206 [Term] id: CCO:B0006353 name: Q9P0U0_HUMAN def: "PC326 protein" [UniProtKB:Q9P0U0] xref: EMBL:AAF67474.1 xref: UniProtKB:Q9H0M1 xref: UniProtKB:Q9P0U0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006055 ! IQWD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008509 ! supt5h-iqwd1 physical interaction [Term] id: CCO:B0010364 name: 1433B_HUMAN-N-acetylthreonine2 def: "Protein 1433B_HUMAN with the residue 2 substituted with N-acetylthreonine" [UniProtKB:P31946] comment: By similarity xref: UniProtKB:P31946 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005480 ! 1433B_HUMAN [Term] id: CCO:B0010365 name: 1433B_HUMAN-Phosphoserine186 def: "Protein 1433B_HUMAN with the residue 186 substituted with Phosphoserine" [UniProtKB:P31946] comment: By similarity xref: UniProtKB:P31946 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005480 ! 1433B_HUMAN [Term] id: CCO:B0010366 name: 1433E_HUMAN-N-acetylmethionine1 def: "Protein 1433E_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P62258] xref: UniProtKB:P62258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005488 ! 1433E_HUMAN [Term] id: CCO:B0010367 name: 1433E_HUMAN-Phosphoserine210 def: "Protein 1433E_HUMAN with the residue 210 substituted with Phosphoserine" [UniProtKB:P62258] comment: By similarity xref: UniProtKB:P62258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005488 ! 1433E_HUMAN [Term] id: CCO:B0010368 name: 1433F_HUMAN-N-acetylglycine2 def: "Protein 1433F_HUMAN with the residue 2 substituted with N-acetylglycine" [UniProtKB:Q04917] xref: UniProtKB:Q04917 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005490 ! 1433F_HUMAN [Term] id: CCO:B0010369 name: 1433G_HUMAN-N-acetylvaline2 def: "Protein 1433G_HUMAN with the residue 2 substituted with N-acetylvaline" [UniProtKB:P61981] xref: UniProtKB:P61981 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005489 ! 1433G_HUMAN [Term] id: CCO:B0010370 name: 1433S_HUMAN-Phosphoserine64 def: "Protein 1433S_HUMAN with the residue 64 substituted with Phosphoserine" [UniProtKB:P31947] comment: By similarity xref: UniProtKB:P31947 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001584 ! 1433S_HUMAN [Term] id: CCO:B0010371 name: 1433S_HUMAN-Phosphoserine216 def: "Protein 1433S_HUMAN with the residue 216 substituted with Phosphoserine" [UniProtKB:P31947] comment: By similarity xref: UniProtKB:P31947 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001584 ! 1433S_HUMAN [Term] id: CCO:B0010372 name: 1433S_HUMAN-Phosphoserine248 def: "Protein 1433S_HUMAN with the residue 248 substituted with Phosphoserine" [UniProtKB:P31947] xref: UniProtKB:P31947 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001584 ! 1433S_HUMAN [Term] id: CCO:B0010373 name: 1433Z_HUMAN-N-acetylmethionine1 def: "Protein 1433Z_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P63104] xref: UniProtKB:P63104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:B0010374 name: 1433Z_HUMAN-Phosphoserine184 def: "Protein 1433Z_HUMAN with the residue 184 substituted with Phosphoserine" [UniProtKB:P63104] comment: By similarity xref: UniProtKB:P63104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:B0010375 name: 1433Z_HUMAN-Phosphothreonine232 def: "Protein 1433Z_HUMAN with the residue 232 substituted with Phosphothreonine" [UniProtKB:P63104] xref: UniProtKB:P63104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:B0010376 name: 2A5D_HUMAN-Phosphoserine598 def: "Protein 2A5D_HUMAN with the residue 598 substituted with Phosphoserine" [UniProtKB:Q14738] xref: UniProtKB:Q14738 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005515 ! 2A5D_HUMAN [Term] id: CCO:B0010378 name: 4ET_HUMAN-Phosphoserine78 def: "Protein 4ET_HUMAN with the residue 78 substituted with Phosphoserine" [UniProtKB:Q9NRA8] comment: By similarity xref: UniProtKB:Q9NRA8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006012 ! 4ET_HUMAN [Term] id: CCO:B0010379 name: 4ET_HUMAN-Phosphoserine587 def: "Protein 4ET_HUMAN with the residue 587 substituted with Phosphoserine" [UniProtKB:Q9NRA8] comment: By similarity xref: UniProtKB:Q9NRA8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006012 ! 4ET_HUMAN [Term] id: CCO:B0010380 name: 4F2_HUMAN-Phosphoserine2 def: "Protein 4F2_HUMAN with the residue 2 substituted with Phosphoserine" [UniProtKB:P08195] xref: UniProtKB:P08195 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005463 ! 4F2_HUMAN [Term] id: CCO:B0010381 name: 4F2_HUMAN-Phosphothreonine5 def: "Protein 4F2_HUMAN with the residue 5 substituted with Phosphothreonine" [UniProtKB:P08195] xref: UniProtKB:P08195 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005463 ! 4F2_HUMAN [Term] id: CCO:B0010382 name: A4_HUMAN-Phosphoserine198 def: "Protein A4_HUMAN with the residue 198 substituted with Phosphoserine" [UniProtKB:P05067] comment: by CK2; xref: UniProtKB:P05067 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005474 ! A4_HUMAN [Term] id: CCO:B0010383 name: A4_HUMAN-Phosphoserine206 def: "Protein A4_HUMAN with the residue 206 substituted with Phosphoserine" [UniProtKB:P05067] comment: by CK1; xref: UniProtKB:P05067 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005474 ! A4_HUMAN [Term] id: CCO:B0010384 name: A4_HUMAN-Phosphothreonine729 def: "Protein A4_HUMAN with the residue 729 substituted with Phosphothreonine" [UniProtKB:P05067] comment: By similarity xref: UniProtKB:P05067 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005474 ! A4_HUMAN [Term] id: CCO:B0010385 name: A4_HUMAN-Phosphoserine730 def: "Protein A4_HUMAN with the residue 730 substituted with Phosphoserine" [UniProtKB:P05067] comment: by APP-kinase I; By similarity xref: UniProtKB:P05067 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005474 ! A4_HUMAN [Term] id: CCO:B0010386 name: A4_HUMAN-Phosphothreonine743 def: "Protein A4_HUMAN with the residue 743 substituted with Phosphothreonine" [UniProtKB:P05067] comment: by CDK5 and MAPK10; xref: UniProtKB:P05067 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005474 ! A4_HUMAN [Term] id: CCO:B0010387 name: A4_HUMAN-Phosphotyrosine757 def: "Protein A4_HUMAN with the residue 757 substituted with Phosphotyrosine" [UniProtKB:P05067] comment: By similarity xref: UniProtKB:P05067 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005474 ! A4_HUMAN [Term] id: CCO:B0010388 name: AAPK1_HUMAN-Phosphothreonine174 def: "Protein AAPK1_HUMAN with the residue 174 substituted with Phosphothreonine" [UniProtKB:Q13131] comment: by STK11; By similarity xref: UniProtKB:Q13131 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005872 ! AAPK1_HUMAN [Term] id: CCO:B0010389 name: AAPK1_HUMAN-Phosphoserine175 def: "Protein AAPK1_HUMAN with the residue 175 substituted with Phosphoserine" [UniProtKB:Q13131] comment: By similarity xref: UniProtKB:Q13131 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005872 ! AAPK1_HUMAN [Term] id: CCO:B0010390 name: AAPK1_HUMAN-Phosphoserine499 def: "Protein AAPK1_HUMAN with the residue 499 substituted with Phosphoserine" [UniProtKB:Q13131] comment: By similarity xref: UniProtKB:Q13131 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005872 ! AAPK1_HUMAN [Term] id: CCO:B0010391 name: AATF_HUMAN-Phosphoserine203 def: "Protein AATF_HUMAN with the residue 203 substituted with Phosphoserine" [UniProtKB:Q9NY61] xref: UniProtKB:Q9NY61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:B0010392 name: AATF_HUMAN-Phosphoserine316 def: "Protein AATF_HUMAN with the residue 316 substituted with Phosphoserine" [UniProtKB:Q9NY61] xref: UniProtKB:Q9NY61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:B0010393 name: AATF_HUMAN-Phosphoserine320 def: "Protein AATF_HUMAN with the residue 320 substituted with Phosphoserine" [UniProtKB:Q9NY61] xref: UniProtKB:Q9NY61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:B0010394 name: AATF_HUMAN-Phosphoserine321 def: "Protein AATF_HUMAN with the residue 321 substituted with Phosphoserine" [UniProtKB:Q9NY61] xref: UniProtKB:Q9NY61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:B0010395 name: ABI1_HUMAN-Phosphoserine183 def: "Protein ABI1_HUMAN with the residue 183 substituted with Phosphoserine" [UniProtKB:Q8IZP0] xref: UniProtKB:Q8IZP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005703 ! ABI1_HUMAN [Term] id: CCO:B0010396 name: ABI1_HUMAN-Phosphoserine225 def: "Protein ABI1_HUMAN with the residue 225 substituted with Phosphoserine" [UniProtKB:Q8IZP0] xref: UniProtKB:Q8IZP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005703 ! ABI1_HUMAN [Term] id: CCO:B0010397 name: ABI1_HUMAN-Phosphotyrosine333 def: "Protein ABI1_HUMAN with the residue 333 substituted with Phosphotyrosine" [UniProtKB:Q8IZP0] xref: UniProtKB:Q8IZP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005703 ! ABI1_HUMAN [Term] id: CCO:B0010398 name: ABL1_HUMAN-Phosphotyrosine185 def: "Protein ABL1_HUMAN with the residue 185 substituted with Phosphotyrosine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010399 name: ABL1_HUMAN-Phosphotyrosine226 def: "Protein ABL1_HUMAN with the residue 226 substituted with Phosphotyrosine" [UniProtKB:P00519] comment: by autocatalysis; xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010400 name: ABL1_HUMAN-Phosphotyrosine253 def: "Protein ABL1_HUMAN with the residue 253 substituted with Phosphotyrosine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010401 name: ABL1_HUMAN-Phosphotyrosine257 def: "Protein ABL1_HUMAN with the residue 257 substituted with Phosphotyrosine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010402 name: ABL1_HUMAN-Phosphotyrosine264 def: "Protein ABL1_HUMAN with the residue 264 substituted with Phosphotyrosine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010403 name: ABL1_HUMAN-Phosphotyrosine393 def: "Protein ABL1_HUMAN with the residue 393 substituted with Phosphotyrosine" [UniProtKB:P00519] comment: by autocatalysis and SRC-type Tyr-kinases; xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010404 name: ABL1_HUMAN-Phosphothreonine394 def: "Protein ABL1_HUMAN with the residue 394 substituted with Phosphothreonine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010405 name: ABL1_HUMAN-Phosphoserine446 def: "Protein ABL1_HUMAN with the residue 446 substituted with Phosphoserine" [UniProtKB:P00519] comment: By similarity xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010406 name: ABL1_HUMAN-Phosphotyrosine469 def: "Protein ABL1_HUMAN with the residue 469 substituted with Phosphotyrosine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010407 name: ABL1_HUMAN-Phosphoserine569 def: "Protein ABL1_HUMAN with the residue 569 substituted with Phosphoserine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010408 name: ABL1_HUMAN-Phosphoserine683 def: "Protein ABL1_HUMAN with the residue 683 substituted with Phosphoserine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010409 name: ABL1_HUMAN-Phosphoserine805 def: "Protein ABL1_HUMAN with the residue 805 substituted with Phosphoserine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010410 name: ABL1_HUMAN-Phosphoserine809 def: "Protein ABL1_HUMAN with the residue 809 substituted with Phosphoserine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010411 name: ABL1_HUMAN-Phosphoserine949 def: "Protein ABL1_HUMAN with the residue 949 substituted with Phosphoserine" [UniProtKB:P00519] xref: UniProtKB:P00519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001461 ! ABL1_HUMAN [Term] id: CCO:B0010427 name: ACK1_HUMAN-Phosphoserine149 def: "Protein ACK1_HUMAN with the residue 149 substituted with Phosphoserine" [UniProtKB:Q07912] xref: UniProtKB:Q07912 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005836 ! ACK1_HUMAN [Term] id: CCO:B0010428 name: ACK1_HUMAN-Phosphotyrosine284 def: "Protein ACK1_HUMAN with the residue 284 substituted with Phosphotyrosine" [UniProtKB:Q07912] comment: by autocatalysis; xref: UniProtKB:Q07912 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005836 ! ACK1_HUMAN [Term] id: CCO:B0010429 name: ACK1_HUMAN-Phosphotyrosine518 def: "Protein ACK1_HUMAN with the residue 518 substituted with Phosphotyrosine" [UniProtKB:Q07912] xref: UniProtKB:Q07912 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005836 ! ACK1_HUMAN [Term] id: CCO:B0010430 name: ACK1_HUMAN-Phosphotyrosine826 def: "Protein ACK1_HUMAN with the residue 826 substituted with Phosphotyrosine" [UniProtKB:Q07912] xref: UniProtKB:Q07912 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005836 ! ACK1_HUMAN [Term] id: CCO:B0010431 name: ACK1_HUMAN-Phosphotyrosine857 def: "Protein ACK1_HUMAN with the residue 857 substituted with Phosphotyrosine" [UniProtKB:Q07912] xref: UniProtKB:Q07912 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005836 ! ACK1_HUMAN [Term] id: CCO:B0010432 name: ACK1_HUMAN-Phosphotyrosine858 def: "Protein ACK1_HUMAN with the residue 858 substituted with Phosphotyrosine" [UniProtKB:Q07912] xref: UniProtKB:Q07912 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005836 ! ACK1_HUMAN [Term] id: CCO:B0010433 name: ACL6A_HUMAN-Phosphoserine233 def: "Protein ACL6A_HUMAN with the residue 233 substituted with Phosphoserine" [UniProtKB:O96019] xref: UniProtKB:O96019 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005366 ! ACL6A_HUMAN [Term] id: CCO:B0010434 name: ACSA_HUMAN-Phosphoserine30 def: "Protein ACSA_HUMAN with the residue 30 substituted with Phosphoserine" [UniProtKB:Q9NR19] xref: UniProtKB:Q9NR19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005570 ! ACSA_HUMAN [Term] id: CCO:B0010435 name: ACSA_HUMAN-Phosphoserine263 def: "Protein ACSA_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:Q9NR19] comment: By similarity xref: UniProtKB:Q9NR19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005570 ! ACSA_HUMAN [Term] id: CCO:B0010436 name: ACSA_HUMAN-Phosphoserine267 def: "Protein ACSA_HUMAN with the residue 267 substituted with Phosphoserine" [UniProtKB:Q9NR19] comment: By similarity xref: UniProtKB:Q9NR19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005570 ! ACSA_HUMAN [Term] id: CCO:B0010437 name: ACTA_HUMAN-N-acetylglutamate3 def: "Protein ACTA_HUMAN with the residue 3 substituted with N-acetylglutamate" [UniProtKB:P62736] comment: By similarity xref: UniProtKB:P62736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005810 ! ACTA_HUMAN [Term] id: CCO:B0010438 name: ACTA_HUMAN-Tele-methylhistidine75 def: "Protein ACTA_HUMAN with the residue 75 substituted with Tele-methylhistidine" [UniProtKB:P62736] comment: By similarity xref: UniProtKB:P62736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005810 ! ACTA_HUMAN [Term] id: CCO:B0010439 name: ACTA_HUMAN-Nitrated tyrosine296 def: "Protein ACTA_HUMAN with the residue 296 substituted with Nitrated tyrosine" [UniProtKB:P62736] xref: UniProtKB:P62736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005810 ! ACTA_HUMAN [Term] id: CCO:B0010440 name: ACTB_HUMAN-N-acetylmethionine1 def: "Protein ACTB_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P60709] comment: By similarity xref: UniProtKB:P60709 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005775 ! ACTB_HUMAN [Term] id: CCO:B0010441 name: ACTB_HUMAN-N-acetylaspartate2 def: "Protein ACTB_HUMAN with the residue 2 substituted with N-acetylaspartate" [UniProtKB:P60709] xref: UniProtKB:P60709 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005775 ! ACTB_HUMAN [Term] id: CCO:B0010442 name: ACTB_HUMAN-Tele-methylhistidine73 def: "Protein ACTB_HUMAN with the residue 73 substituted with Tele-methylhistidine" [UniProtKB:P60709] comment: By similarity xref: UniProtKB:P60709 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005775 ! ACTB_HUMAN [Term] id: CCO:B0010443 name: ACTB_HUMAN-Phosphotyrosine166 def: "Protein ACTB_HUMAN with the residue 166 substituted with Phosphotyrosine" [UniProtKB:P60709] xref: UniProtKB:P60709 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005775 ! ACTB_HUMAN [Term] id: CCO:B0010444 name: ACTB_HUMAN-Phosphotyrosine218 def: "Protein ACTB_HUMAN with the residue 218 substituted with Phosphotyrosine" [UniProtKB:P60709] xref: UniProtKB:P60709 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005775 ! ACTB_HUMAN [Term] id: CCO:B0010445 name: ACTB_HUMAN-Phosphotyrosine294 def: "Protein ACTB_HUMAN with the residue 294 substituted with Phosphotyrosine" [UniProtKB:P60709] xref: UniProtKB:P60709 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005775 ! ACTB_HUMAN [Term] id: CCO:B0010446 name: ACTN1_HUMAN-Phosphotyrosine12 def: "Protein ACTN1_HUMAN with the residue 12 substituted with Phosphotyrosine" [UniProtKB:P12814] comment: by FAK1; xref: UniProtKB:P12814 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005948 ! ACTN1_HUMAN [Term] id: CCO:B0010447 name: ACTN1_HUMAN-Phosphothreonine50 def: "Protein ACTN1_HUMAN with the residue 50 substituted with Phosphothreonine" [UniProtKB:P12814] xref: UniProtKB:P12814 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005948 ! ACTN1_HUMAN [Term] id: CCO:B0010448 name: ACTN1_HUMAN-Phosphoserine140 def: "Protein ACTN1_HUMAN with the residue 140 substituted with Phosphoserine" [UniProtKB:P12814] xref: UniProtKB:P12814 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005948 ! ACTN1_HUMAN [Term] id: CCO:B0010450 name: ACV1B_HUMAN-Phosphotyrosine380 def: "Protein ACV1B_HUMAN with the residue 380 substituted with Phosphotyrosine" [UniProtKB:P36896] xref: UniProtKB:P36896 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001597 ! ACV1B_HUMAN [Term] id: CCO:B0010451 name: ADA15_HUMAN-Phosphotyrosine715 def: "Protein ADA15_HUMAN with the residue 715 substituted with Phosphotyrosine" [UniProtKB:Q13444] xref: UniProtKB:Q13444 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005909 ! ADA15_HUMAN [Term] id: CCO:B0010452 name: ADA15_HUMAN-Phosphotyrosine735 def: "Protein ADA15_HUMAN with the residue 735 substituted with Phosphotyrosine" [UniProtKB:Q13444] xref: UniProtKB:Q13444 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005909 ! ADA15_HUMAN [Term] id: CCO:B0010453 name: ADA17_HUMAN-Phosphotyrosine379 def: "Protein ADA17_HUMAN with the residue 379 substituted with Phosphotyrosine" [UniProtKB:P78536] xref: UniProtKB:P78536 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005712 ! ADA17_HUMAN [Term] id: CCO:B0010454 name: ADA17_HUMAN-Phosphoserine382 def: "Protein ADA17_HUMAN with the residue 382 substituted with Phosphoserine" [UniProtKB:P78536] xref: UniProtKB:P78536 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005712 ! ADA17_HUMAN [Term] id: CCO:B0010455 name: ADA17_HUMAN-Phosphothreonine735 def: "Protein ADA17_HUMAN with the residue 735 substituted with Phosphothreonine" [UniProtKB:P78536] comment: by MAPK; xref: UniProtKB:P78536 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005712 ! ADA17_HUMAN [Term] id: CCO:B0010456 name: ADA17_HUMAN-Phosphoserine791 def: "Protein ADA17_HUMAN with the residue 791 substituted with Phosphoserine" [UniProtKB:P78536] xref: UniProtKB:P78536 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005712 ! ADA17_HUMAN [Term] id: CCO:B0010457 name: ADA17_HUMAN-Phosphoserine819 def: "Protein ADA17_HUMAN with the residue 819 substituted with Phosphoserine" [UniProtKB:P78536] xref: UniProtKB:P78536 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005712 ! ADA17_HUMAN [Term] id: CCO:B0010458 name: ADAM9_HUMAN-Phosphoserine758 def: "Protein ADAM9_HUMAN with the residue 758 substituted with Phosphoserine" [UniProtKB:Q13443] xref: UniProtKB:Q13443 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005372 ! ADAM9_HUMAN [Term] id: CCO:B0010459 name: ADAM9_HUMAN-Phosphothreonine761 def: "Protein ADAM9_HUMAN with the residue 761 substituted with Phosphothreonine" [UniProtKB:Q13443] xref: UniProtKB:Q13443 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005372 ! ADAM9_HUMAN [Term] id: CCO:B0010460 name: ADT2_HUMAN-N-acetylthreonine2 def: "Protein ADT2_HUMAN with the residue 2 substituted with N-acetylthreonine" [UniProtKB:P05141] xref: UniProtKB:P05141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005813 ! ADT2_HUMAN [Term] id: CCO:B0010461 name: ADT2_HUMAN-N6-acetyllysine23 def: "Protein ADT2_HUMAN with the residue 23 substituted with N6-acetyllysine" [UniProtKB:P05141] comment: By similarity xref: UniProtKB:P05141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005813 ! ADT2_HUMAN [Term] id: CCO:B0010462 name: ADT2_HUMAN-Phosphoserine42 def: "Protein ADT2_HUMAN with the residue 42 substituted with Phosphoserine" [UniProtKB:P05141] comment: By similarity xref: UniProtKB:P05141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005813 ! ADT2_HUMAN [Term] id: CCO:B0010463 name: ADT2_HUMAN-N6-acetyllysine92 def: "Protein ADT2_HUMAN with the residue 92 substituted with N6-acetyllysine" [UniProtKB:P05141] comment: By similarity xref: UniProtKB:P05141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005813 ! ADT2_HUMAN [Term] id: CCO:B0010464 name: ADT2_HUMAN-N6-acetyllysine163 def: "Protein ADT2_HUMAN with the residue 163 substituted with N6-acetyllysine" [UniProtKB:P05141] comment: By similarity xref: UniProtKB:P05141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005813 ! ADT2_HUMAN [Term] id: CCO:B0010465 name: ADT2_HUMAN-N6-acetyllysine166 def: "Protein ADT2_HUMAN with the residue 166 substituted with N6-acetyllysine" [UniProtKB:P05141] comment: By similarity xref: UniProtKB:P05141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005813 ! ADT2_HUMAN [Term] id: CCO:B0010466 name: ADT2_HUMAN-N6-acetyllysine199 def: "Protein ADT2_HUMAN with the residue 199 substituted with N6-acetyllysine" [UniProtKB:P05141] comment: By similarity xref: UniProtKB:P05141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005813 ! ADT2_HUMAN [Term] id: CCO:B0010467 name: AF1L2_HUMAN-Phosphothreonine345 def: "Protein AF1L2_HUMAN with the residue 345 substituted with Phosphothreonine" [UniProtKB:Q8N4X5] comment: By similarity xref: UniProtKB:Q8N4X5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001964 ! AF1L2_HUMAN [Term] id: CCO:B0010468 name: AF1L2_HUMAN-Phosphotyrosine413 def: "Protein AF1L2_HUMAN with the residue 413 substituted with Phosphotyrosine" [UniProtKB:Q8N4X5] xref: UniProtKB:Q8N4X5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001964 ! AF1L2_HUMAN [Term] id: CCO:B0010469 name: AF1L2_HUMAN-Phosphotyrosine668 def: "Protein AF1L2_HUMAN with the residue 668 substituted with Phosphotyrosine" [UniProtKB:Q8N4X5] xref: UniProtKB:Q8N4X5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001964 ! AF1L2_HUMAN [Term] id: CCO:B0010470 name: AF1L2_HUMAN-Phosphothreonine669 def: "Protein AF1L2_HUMAN with the residue 669 substituted with Phosphothreonine" [UniProtKB:Q8N4X5] xref: UniProtKB:Q8N4X5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001964 ! AF1L2_HUMAN [Term] id: CCO:B0010481 name: AIP_HUMAN-Phosphotyrosine248 def: "Protein AIP_HUMAN with the residue 248 substituted with Phosphotyrosine" [UniProtKB:O00170] xref: UniProtKB:O00170 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005380 ! AIP_HUMAN [Term] id: CCO:B0010482 name: AKAP8_HUMAN-Phosphoserine112 def: "Protein AKAP8_HUMAN with the residue 112 substituted with Phosphoserine" [UniProtKB:O43823] xref: UniProtKB:O43823 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_function CCO:F0008036 ! protein kinase A binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000785 ! nuclear matrix relationship: transformation_of CCO:B0001399 ! AKAP8_HUMAN [Term] id: CCO:B0010483 name: AKAP8_HUMAN-Phosphoserine323 def: "Protein AKAP8_HUMAN with the residue 323 substituted with Phosphoserine" [UniProtKB:O43823] xref: UniProtKB:O43823 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001399 ! AKAP8_HUMAN [Term] id: CCO:B0010484 name: AKAP8_HUMAN-Phosphoserine328 def: "Protein AKAP8_HUMAN with the residue 328 substituted with Phosphoserine" [UniProtKB:O43823] xref: UniProtKB:O43823 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001399 ! AKAP8_HUMAN [Term] id: CCO:B0010485 name: AKAP8_HUMAN-Phosphoserine339 def: "Protein AKAP8_HUMAN with the residue 339 substituted with Phosphoserine" [UniProtKB:O43823] xref: UniProtKB:O43823 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001399 ! AKAP8_HUMAN [Term] id: CCO:B0010486 name: AKAP9_HUMAN-Phosphoserine3869 def: "Protein AKAP9_HUMAN with the residue 3869 substituted with Phosphoserine" [UniProtKB:Q99996] xref: UniProtKB:Q99996 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005588 ! AKAP9_HUMAN [Term] id: CCO:B0010487 name: AKT1_HUMAN-Phosphoserine124 def: "Protein AKT1_HUMAN with the residue 124 substituted with Phosphoserine" [UniProtKB:P31749] xref: UniProtKB:P31749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:B0010488 name: AKT1_HUMAN-Phosphoserine126 def: "Protein AKT1_HUMAN with the residue 126 substituted with Phosphoserine" [UniProtKB:P31749] xref: UniProtKB:P31749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:B0010489 name: AKT1_HUMAN-Phosphoserine129 def: "Protein AKT1_HUMAN with the residue 129 substituted with Phosphoserine" [UniProtKB:P31749] xref: UniProtKB:P31749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:B0010490 name: AKT1_HUMAN-Phosphothreonine308 def: "Protein AKT1_HUMAN with the residue 308 substituted with Phosphothreonine" [UniProtKB:P31749] comment: by PDPK1; xref: UniProtKB:P31749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:B0010491 name: AKT1_HUMAN-Phosphoserine473 def: "Protein AKT1_HUMAN with the residue 473 substituted with Phosphoserine" [UniProtKB:P31749] xref: UniProtKB:P31749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:B0010492 name: AKT1_HUMAN-Phosphotyrosine474 def: "Protein AKT1_HUMAN with the residue 474 substituted with Phosphotyrosine" [UniProtKB:P31749] xref: UniProtKB:P31749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:B0010493 name: AKT2_HUMAN-Phosphothreonine309 def: "Protein AKT2_HUMAN with the residue 309 substituted with Phosphothreonine" [UniProtKB:P31751] comment: by PDPK1; xref: UniProtKB:P31751 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005910 ! AKT2_HUMAN [Term] id: CCO:B0010494 name: AKT2_HUMAN-Phosphoserine474 def: "Protein AKT2_HUMAN with the residue 474 substituted with Phosphoserine" [UniProtKB:P31751] xref: UniProtKB:P31751 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005910 ! AKT2_HUMAN [Term] id: CCO:B0010495 name: AKT3_HUMAN-Phosphoserine120 def: "Protein AKT3_HUMAN with the residue 120 substituted with Phosphoserine" [UniProtKB:Q9Y243] xref: UniProtKB:Q9Y243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005911 ! AKT3_HUMAN [Term] id: CCO:B0010496 name: AKT3_HUMAN-Phosphoserine123 def: "Protein AKT3_HUMAN with the residue 123 substituted with Phosphoserine" [UniProtKB:Q9Y243] xref: UniProtKB:Q9Y243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005911 ! AKT3_HUMAN [Term] id: CCO:B0010497 name: AKT3_HUMAN-Phosphothreonine305 def: "Protein AKT3_HUMAN with the residue 305 substituted with Phosphothreonine" [UniProtKB:Q9Y243] comment: by PDPK1; xref: UniProtKB:Q9Y243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005911 ! AKT3_HUMAN [Term] id: CCO:B0010498 name: AKT3_HUMAN-Phosphoserine472 def: "Protein AKT3_HUMAN with the residue 472 substituted with Phosphoserine" [UniProtKB:Q9Y243] comment: By similarity xref: UniProtKB:Q9Y243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005911 ! AKT3_HUMAN [Term] id: CCO:B0010499 name: ALK_HUMAN-Phosphoserine211 def: "Protein ALK_HUMAN with the residue 211 substituted with Phosphoserine" [UniProtKB:Q9UM73] xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010500 name: ALK_HUMAN-Phosphotyrosine1078 def: "Protein ALK_HUMAN with the residue 1078 substituted with Phosphotyrosine" [UniProtKB:Q9UM73] xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010501 name: ALK_HUMAN-Phosphotyrosine1092 def: "Protein ALK_HUMAN with the residue 1092 substituted with Phosphotyrosine" [UniProtKB:Q9UM73] xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010502 name: ALK_HUMAN-Phosphotyrosine1096 def: "Protein ALK_HUMAN with the residue 1096 substituted with Phosphotyrosine" [UniProtKB:Q9UM73] xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010503 name: ALK_HUMAN-Phosphotyrosine1131 def: "Protein ALK_HUMAN with the residue 1131 substituted with Phosphotyrosine" [UniProtKB:Q9UM73] xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010504 name: ALK_HUMAN-Phosphotyrosine1278 def: "Protein ALK_HUMAN with the residue 1278 substituted with Phosphotyrosine" [UniProtKB:Q9UM73] xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010505 name: ALK_HUMAN-Phosphotyrosine1282 def: "Protein ALK_HUMAN with the residue 1282 substituted with Phosphotyrosine" [UniProtKB:Q9UM73] comment: by autocatalysis; xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010506 name: ALK_HUMAN-Phosphotyrosine1507 def: "Protein ALK_HUMAN with the residue 1507 substituted with Phosphotyrosine" [UniProtKB:Q9UM73] xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010507 name: ALK_HUMAN-Phosphotyrosine1584 def: "Protein ALK_HUMAN with the residue 1584 substituted with Phosphotyrosine" [UniProtKB:Q9UM73] xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010508 name: ALK_HUMAN-Phosphotyrosine1604 def: "Protein ALK_HUMAN with the residue 1604 substituted with Phosphotyrosine" [UniProtKB:Q9UM73] xref: UniProtKB:Q9UM73 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:B0010509 name: AN32A_HUMAN-Phosphoserine158 def: "Protein AN32A_HUMAN with the residue 158 substituted with Phosphoserine" [UniProtKB:P39687] xref: UniProtKB:P39687 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006073 ! AN32A_HUMAN [Term] id: CCO:B0010521 name: ANC2_HUMAN-Phosphoserine218 def: "Protein ANC2_HUMAN with the residue 218 substituted with Phosphoserine" [UniProtKB:Q9UJX6] xref: UniProtKB:Q9UJX6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002216 ! ANC2_HUMAN [Term] id: CCO:B0010522 name: ANC2_HUMAN-Phosphoserine314 def: "Protein ANC2_HUMAN with the residue 314 substituted with Phosphoserine" [UniProtKB:Q9UJX6] xref: UniProtKB:Q9UJX6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002216 ! ANC2_HUMAN [Term] id: CCO:B0010523 name: ANC2_HUMAN-Phosphoserine534 def: "Protein ANC2_HUMAN with the residue 534 substituted with Phosphoserine" [UniProtKB:Q9UJX6] xref: UniProtKB:Q9UJX6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002216 ! ANC2_HUMAN [Term] id: CCO:B0010528 name: ANGI_HUMAN-Pyrrolidone carboxylic acid25 def: "Protein ANGI_HUMAN with the residue 25 substituted with Pyrrolidone carboxylic acid" [UniProtKB:P03950] xref: UniProtKB:P03950 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006220 ! ANGI_HUMAN [Term] id: CCO:B0010529 name: ANKS3_HUMAN-Phosphoserine2 def: "Protein ANKS3_HUMAN with the residue 2 substituted with Phosphoserine" [UniProtKB:Q6ZW76] xref: UniProtKB:Q6ZW76 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005965 ! ANKS3_HUMAN [Term] id: CCO:B0010530 name: ANKS3_HUMAN-Phosphoserine5 def: "Protein ANKS3_HUMAN with the residue 5 substituted with Phosphoserine" [UniProtKB:Q6ZW76] xref: UniProtKB:Q6ZW76 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005965 ! ANKS3_HUMAN [Term] id: CCO:B0010531 name: ANKS3_HUMAN-Phosphoserine9 def: "Protein ANKS3_HUMAN with the residue 9 substituted with Phosphoserine" [UniProtKB:Q6ZW76] xref: UniProtKB:Q6ZW76 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005965 ! ANKS3_HUMAN [Term] id: CCO:B0010532 name: ANKS3_HUMAN-Phosphoserine320 def: "Protein ANKS3_HUMAN with the residue 320 substituted with Phosphoserine" [UniProtKB:Q6ZW76] xref: UniProtKB:Q6ZW76 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005965 ! ANKS3_HUMAN [Term] id: CCO:B0010533 name: ANKZ1_HUMAN-Phosphoserine258 def: "Protein ANKZ1_HUMAN with the residue 258 substituted with Phosphoserine" [UniProtKB:Q9H8Y5] xref: UniProtKB:Q9H8Y5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006329 ! ANKZ1_HUMAN [Term] id: CCO:B0010534 name: ANKZ1_HUMAN-Phosphoserine361 def: "Protein ANKZ1_HUMAN with the residue 361 substituted with Phosphoserine" [UniProtKB:Q9H8Y5] xref: UniProtKB:Q9H8Y5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006329 ! ANKZ1_HUMAN [Term] id: CCO:B0010535 name: ANKZ1_HUMAN-Phosphoserine398 def: "Protein ANKZ1_HUMAN with the residue 398 substituted with Phosphoserine" [UniProtKB:Q9H8Y5] xref: UniProtKB:Q9H8Y5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006329 ! ANKZ1_HUMAN [Term] id: CCO:B0010536 name: ANKZ1_HUMAN-Phosphothreonine607 def: "Protein ANKZ1_HUMAN with the residue 607 substituted with Phosphothreonine" [UniProtKB:Q9H8Y5] xref: UniProtKB:Q9H8Y5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006329 ! ANKZ1_HUMAN [Term] id: CCO:B0010537 name: ANLN_HUMAN-Phosphoserine99 def: "Protein ANLN_HUMAN with the residue 99 substituted with Phosphoserine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010538 name: ANLN_HUMAN-Phosphoserine182 def: "Protein ANLN_HUMAN with the residue 182 substituted with Phosphoserine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010539 name: ANLN_HUMAN-Phosphothreonine194 def: "Protein ANLN_HUMAN with the residue 194 substituted with Phosphothreonine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010540 name: ANLN_HUMAN-Phosphothreonine320 def: "Protein ANLN_HUMAN with the residue 320 substituted with Phosphothreonine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010541 name: ANLN_HUMAN-Phosphoserine323 def: "Protein ANLN_HUMAN with the residue 323 substituted with Phosphoserine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010542 name: ANLN_HUMAN-Phosphoserine362 def: "Protein ANLN_HUMAN with the residue 362 substituted with Phosphoserine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010543 name: ANLN_HUMAN-Phosphothreonine368 def: "Protein ANLN_HUMAN with the residue 368 substituted with Phosphothreonine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010544 name: ANLN_HUMAN-Phosphothreonine401 def: "Protein ANLN_HUMAN with the residue 401 substituted with Phosphothreonine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010545 name: ANLN_HUMAN-Phosphoserine449 def: "Protein ANLN_HUMAN with the residue 449 substituted with Phosphoserine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010546 name: ANLN_HUMAN-Phosphoserine485 def: "Protein ANLN_HUMAN with the residue 485 substituted with Phosphoserine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010547 name: ANLN_HUMAN-Phosphothreonine515 def: "Protein ANLN_HUMAN with the residue 515 substituted with Phosphothreonine" [UniProtKB:Q9NQW6] comment: By similarity xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010548 name: ANLN_HUMAN-Phosphoserine637 def: "Protein ANLN_HUMAN with the residue 637 substituted with Phosphoserine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010549 name: ANLN_HUMAN-Phosphoserine927 def: "Protein ANLN_HUMAN with the residue 927 substituted with Phosphoserine" [UniProtKB:Q9NQW6] xref: UniProtKB:Q9NQW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002155 ! ANLN_HUMAN [Term] id: CCO:B0010550 name: ANXA1_HUMAN-N-acetylalanine2 def: "Protein ANXA1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P04083] xref: UniProtKB:P04083 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001479 ! ANXA1_HUMAN [Term] id: CCO:B0010551 name: ANXA1_HUMAN-Phosphoserine5 def: "Protein ANXA1_HUMAN with the residue 5 substituted with Phosphoserine" [UniProtKB:P04083] comment: by TRPM7; xref: UniProtKB:P04083 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001479 ! ANXA1_HUMAN [Term] id: CCO:B0010552 name: ANXA1_HUMAN-Phosphotyrosine21 def: "Protein ANXA1_HUMAN with the residue 21 substituted with Phosphotyrosine" [UniProtKB:P04083] comment: by EGFR; xref: UniProtKB:P04083 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001479 ! ANXA1_HUMAN [Term] id: CCO:B0010553 name: ANXA1_HUMAN-Phosphothreonine24 def: "Protein ANXA1_HUMAN with the residue 24 substituted with Phosphothreonine" [UniProtKB:P04083] xref: UniProtKB:P04083 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001479 ! ANXA1_HUMAN [Term] id: CCO:B0010554 name: ANXA1_HUMAN-Phosphoserine27 def: "Protein ANXA1_HUMAN with the residue 27 substituted with Phosphoserine" [UniProtKB:P04083] comment: by PKC; xref: UniProtKB:P04083 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001479 ! ANXA1_HUMAN [Term] id: CCO:B0010555 name: ANXA1_HUMAN-Phosphotyrosine207 def: "Protein ANXA1_HUMAN with the residue 207 substituted with Phosphotyrosine" [UniProtKB:P04083] xref: UniProtKB:P04083 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001479 ! ANXA1_HUMAN [Term] id: CCO:B0010556 name: ANXA2_HUMAN-N-acetylserine2 def: "Protein ANXA2_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P07355] xref: UniProtKB:P07355 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005736 ! ANXA2_HUMAN [Term] id: CCO:B0010557 name: ANXA2_HUMAN-Phosphoserine18 def: "Protein ANXA2_HUMAN with the residue 18 substituted with Phosphoserine" [UniProtKB:P07355] xref: UniProtKB:P07355 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005736 ! ANXA2_HUMAN [Term] id: CCO:B0010558 name: ANXA2_HUMAN-Phosphothreonine19 def: "Protein ANXA2_HUMAN with the residue 19 substituted with Phosphothreonine" [UniProtKB:P07355] xref: UniProtKB:P07355 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005736 ! ANXA2_HUMAN [Term] id: CCO:B0010559 name: ANXA2_HUMAN-Phosphotyrosine24 def: "Protein ANXA2_HUMAN with the residue 24 substituted with Phosphotyrosine" [UniProtKB:P07355] comment: by SRC; xref: UniProtKB:P07355 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005736 ! ANXA2_HUMAN [Term] id: CCO:B0010560 name: ANXA2_HUMAN-Phosphoserine26 def: "Protein ANXA2_HUMAN with the residue 26 substituted with Phosphoserine" [UniProtKB:P07355] comment: by PKC; xref: UniProtKB:P07355 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005736 ! ANXA2_HUMAN [Term] id: CCO:B0010561 name: ANXA2_HUMAN-Phosphotyrosine30 def: "Protein ANXA2_HUMAN with the residue 30 substituted with Phosphotyrosine" [UniProtKB:P07355] xref: UniProtKB:P07355 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005736 ! ANXA2_HUMAN [Term] id: CCO:B0010562 name: ANXA6_HUMAN-N-acetylalanine2 def: "Protein ANXA6_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P08133] xref: UniProtKB:P08133 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005731 ! ANXA6_HUMAN [Term] id: CCO:B0010563 name: AP2A_HUMAN-Phosphoserine239 def: "Protein AP2A_HUMAN with the residue 239 substituted with Phosphoserine" [UniProtKB:P05549] comment: by PKA; xref: UniProtKB:P05549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:B0010564 name: AP2B1_HUMAN-Phosphotyrosine737 def: "Protein AP2B1_HUMAN with the residue 737 substituted with Phosphotyrosine" [UniProtKB:P63010] xref: UniProtKB:P63010 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005197 ! AP2B1_HUMAN [Term] id: CCO:B0010565 name: AP2B_HUMAN-Phosphoserine258 def: "Protein AP2B_HUMAN with the residue 258 substituted with Phosphoserine" [UniProtKB:Q92481] comment: by PKA; By similarity xref: UniProtKB:Q92481 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005680 ! AP2B_HUMAN [Term] id: CCO:B0010566 name: AP2C_HUMAN-Phosphoserine252 def: "Protein AP2C_HUMAN with the residue 252 substituted with Phosphoserine" [UniProtKB:Q92754] comment: by PKA; By similarity xref: UniProtKB:Q92754 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005377 ! AP2C_HUMAN [Term] id: CCO:B0010567 name: APC_HUMAN-Phosphoserine1038 def: "Protein APC_HUMAN with the residue 1038 substituted with Phosphoserine" [UniProtKB:P25054] comment: By similarity xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001678 ! beta-catenin binding relationship: has_function CCO:F0001679 ! microtubule binding relationship: has_function CCO:F0002008 ! protein kinase CK2 regulator activity relationship: has_function CCO:F0004210 ! protein kinase binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000103 ! kinetochore relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0000783 ! lateral plasma membrane relationship: located_in CCO:C0001067 ! beta-catenin destruction complex relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010568 name: APC_HUMAN-Phosphoserine1180 def: "Protein APC_HUMAN with the residue 1180 substituted with Phosphoserine" [UniProtKB:P25054] comment: By similarity xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010569 name: APC_HUMAN-Phosphoserine1371 def: "Protein APC_HUMAN with the residue 1371 substituted with Phosphoserine" [UniProtKB:P25054] comment: By similarity xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010570 name: APC_HUMAN-Phosphothreonine1697 def: "Protein APC_HUMAN with the residue 1697 substituted with Phosphothreonine" [UniProtKB:P25054] comment: By similarity xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010571 name: APC_HUMAN-Phosphoserine1861 def: "Protein APC_HUMAN with the residue 1861 substituted with Phosphoserine" [UniProtKB:P25054] xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010572 name: APC_HUMAN-Phosphoserine1863 def: "Protein APC_HUMAN with the residue 1863 substituted with Phosphoserine" [UniProtKB:P25054] xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010573 name: APC_HUMAN-Phosphoserine1864 def: "Protein APC_HUMAN with the residue 1864 substituted with Phosphoserine" [UniProtKB:P25054] xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010574 name: APC_HUMAN-Phosphoserine2283 def: "Protein APC_HUMAN with the residue 2283 substituted with Phosphoserine" [UniProtKB:P25054] xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010575 name: APC_HUMAN-Phosphoserine2398 def: "Protein APC_HUMAN with the residue 2398 substituted with Phosphoserine" [UniProtKB:P25054] xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010576 name: APC_HUMAN-Phosphoserine2674 def: "Protein APC_HUMAN with the residue 2674 substituted with Phosphoserine" [UniProtKB:P25054] comment: By similarity xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010577 name: APC_HUMAN-Phosphoserine2710 def: "Protein APC_HUMAN with the residue 2710 substituted with Phosphoserine" [UniProtKB:P25054] comment: By similarity xref: UniProtKB:P25054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001556 ! APC_HUMAN [Term] id: CCO:B0010585 name: ARAF_HUMAN-Phosphoserine257 def: "Protein ARAF_HUMAN with the residue 257 substituted with Phosphoserine" [UniProtKB:P10398] xref: UniProtKB:P10398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005708 ! ARAF_HUMAN [Term] id: CCO:B0010586 name: ARAF_HUMAN-Phosphoserine582 def: "Protein ARAF_HUMAN with the residue 582 substituted with Phosphoserine" [UniProtKB:P10398] xref: UniProtKB:P10398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005708 ! ARAF_HUMAN [Term] id: CCO:B0010587 name: ARD1A_HUMAN-Phosphoserine182 def: "Protein ARD1A_HUMAN with the residue 182 substituted with Phosphoserine" [UniProtKB:P41227] xref: UniProtKB:P41227 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005243 ! ARD1A_HUMAN [Term] id: CCO:B0010588 name: ARD1A_HUMAN-Phosphoserine186 def: "Protein ARD1A_HUMAN with the residue 186 substituted with Phosphoserine" [UniProtKB:P41227] xref: UniProtKB:P41227 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005243 ! ARD1A_HUMAN [Term] id: CCO:B0010589 name: ARFG1_HUMAN-Phosphothreonine135 def: "Protein ARFG1_HUMAN with the residue 135 substituted with Phosphothreonine" [UniProtKB:Q8N6T3] xref: UniProtKB:Q8N6T3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006225 ! ARFG1_HUMAN [Term] id: CCO:B0010590 name: ARFG1_HUMAN-Phosphothreonine189 def: "Protein ARFG1_HUMAN with the residue 189 substituted with Phosphothreonine" [UniProtKB:Q8N6T3] xref: UniProtKB:Q8N6T3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006225 ! ARFG1_HUMAN [Term] id: CCO:B0010591 name: ARFG1_HUMAN-Phosphoserine246 def: "Protein ARFG1_HUMAN with the residue 246 substituted with Phosphoserine" [UniProtKB:Q8N6T3] xref: UniProtKB:Q8N6T3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006225 ! ARFG1_HUMAN [Term] id: CCO:B0010592 name: ARFG1_HUMAN-Phosphoserine343 def: "Protein ARFG1_HUMAN with the residue 343 substituted with Phosphoserine" [UniProtKB:Q8N6T3] comment: By similarity xref: UniProtKB:Q8N6T3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006225 ! ARFG1_HUMAN [Term] id: CCO:B0010593 name: ARFG1_HUMAN-Phosphoserine345 def: "Protein ARFG1_HUMAN with the residue 345 substituted with Phosphoserine" [UniProtKB:Q8N6T3] comment: By similarity xref: UniProtKB:Q8N6T3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006225 ! ARFG1_HUMAN [Term] id: CCO:B0010594 name: ARFG1_HUMAN-Phosphoserine348 def: "Protein ARFG1_HUMAN with the residue 348 substituted with Phosphoserine" [UniProtKB:Q8N6T3] comment: By similarity xref: UniProtKB:Q8N6T3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006225 ! ARFG1_HUMAN [Term] id: CCO:B0010595 name: ARFG1_HUMAN-Phosphoserine361 def: "Protein ARFG1_HUMAN with the residue 361 substituted with Phosphoserine" [UniProtKB:Q8N6T3] comment: By similarity xref: UniProtKB:Q8N6T3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006225 ! ARFG1_HUMAN [Term] id: CCO:B0010596 name: ARI1A_HUMAN-Phosphoserine363 def: "Protein ARI1A_HUMAN with the residue 363 substituted with Phosphoserine" [UniProtKB:O14497] xref: UniProtKB:O14497 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006007 ! ARI1A_HUMAN [Term] id: CCO:B0010597 name: ARI1A_HUMAN-Phosphoserine604 def: "Protein ARI1A_HUMAN with the residue 604 substituted with Phosphoserine" [UniProtKB:O14497] xref: UniProtKB:O14497 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006007 ! ARI1A_HUMAN [Term] id: CCO:B0010598 name: ARI1A_HUMAN-Phosphoserine696 def: "Protein ARI1A_HUMAN with the residue 696 substituted with Phosphoserine" [UniProtKB:O14497] xref: UniProtKB:O14497 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006007 ! ARI1A_HUMAN [Term] id: CCO:B0010599 name: ARI1A_HUMAN-Phosphoserine772 def: "Protein ARI1A_HUMAN with the residue 772 substituted with Phosphoserine" [UniProtKB:O14497] xref: UniProtKB:O14497 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006007 ! ARI1A_HUMAN [Term] id: CCO:B0010600 name: ARI1A_HUMAN-Phosphoserine1755 def: "Protein ARI1A_HUMAN with the residue 1755 substituted with Phosphoserine" [UniProtKB:O14497] xref: UniProtKB:O14497 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006007 ! ARI1A_HUMAN [Term] id: CCO:B0010601 name: ARI2_HUMAN-Phosphoserine353 def: "Protein ARI2_HUMAN with the residue 353 substituted with Phosphoserine" [UniProtKB:O95376] xref: UniProtKB:O95376 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005288 ! ARI2_HUMAN [Term] id: CCO:B0010602 name: ARI4A_HUMAN-Phosphoserine1109 def: "Protein ARI4A_HUMAN with the residue 1109 substituted with Phosphoserine" [UniProtKB:P29374] xref: UniProtKB:P29374 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005693 ! ARI4A_HUMAN [Term] id: CCO:B0010603 name: ARL8B_HUMAN-N-acetylmethionine1 def: "Protein ARL8B_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:Q9NVJ2] xref: UniProtKB:Q9NVJ2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006324 ! ARL8B_HUMAN [Term] id: CCO:B0010604 name: ARP8_HUMAN-Phosphoserine132 def: "Protein ARP8_HUMAN with the residue 132 substituted with Phosphoserine" [UniProtKB:Q9H981] xref: UniProtKB:Q9H981 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006058 ! ARP8_HUMAN [Term] id: CCO:B0010607 name: ASPM_HUMAN-Phosphoserine14 def: "Protein ASPM_HUMAN with the residue 14 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010608 name: ASPM_HUMAN-Phosphoserine35 def: "Protein ASPM_HUMAN with the residue 35 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010609 name: ASPM_HUMAN-Phosphoserine222 def: "Protein ASPM_HUMAN with the residue 222 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010610 name: ASPM_HUMAN-Phosphoserine225 def: "Protein ASPM_HUMAN with the residue 225 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010611 name: ASPM_HUMAN-Phosphoserine263 def: "Protein ASPM_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010612 name: ASPM_HUMAN-Phosphoserine267 def: "Protein ASPM_HUMAN with the residue 267 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010613 name: ASPM_HUMAN-Phosphoserine270 def: "Protein ASPM_HUMAN with the residue 270 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010614 name: ASPM_HUMAN-Phosphoserine280 def: "Protein ASPM_HUMAN with the residue 280 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010615 name: ASPM_HUMAN-Phosphoserine283 def: "Protein ASPM_HUMAN with the residue 283 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010616 name: ASPM_HUMAN-Phosphoserine348 def: "Protein ASPM_HUMAN with the residue 348 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010617 name: ASPM_HUMAN-Phosphoserine367 def: "Protein ASPM_HUMAN with the residue 367 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010618 name: ASPM_HUMAN-Phosphoserine370 def: "Protein ASPM_HUMAN with the residue 370 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010619 name: ASPM_HUMAN-Phosphoserine392 def: "Protein ASPM_HUMAN with the residue 392 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010620 name: ASPM_HUMAN-Phosphoserine425 def: "Protein ASPM_HUMAN with the residue 425 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010621 name: ASPM_HUMAN-Phosphoserine463 def: "Protein ASPM_HUMAN with the residue 463 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010622 name: ASPM_HUMAN-Phosphothreonine563 def: "Protein ASPM_HUMAN with the residue 563 substituted with Phosphothreonine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010623 name: ASPM_HUMAN-Phosphoserine605 def: "Protein ASPM_HUMAN with the residue 605 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010624 name: ASPM_HUMAN-Phosphothreonine647 def: "Protein ASPM_HUMAN with the residue 647 substituted with Phosphothreonine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010625 name: ASPM_HUMAN-Phosphoserine1103 def: "Protein ASPM_HUMAN with the residue 1103 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010626 name: ASPM_HUMAN-Phosphoserine2429 def: "Protein ASPM_HUMAN with the residue 2429 substituted with Phosphoserine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010627 name: ASPM_HUMAN-Phosphothreonine3435 def: "Protein ASPM_HUMAN with the residue 3435 substituted with Phosphothreonine" [UniProtKB:Q8IZT6] xref: UniProtKB:Q8IZT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001956 ! ASPM_HUMAN [Term] id: CCO:B0010628 name: ASPP1_HUMAN-Phosphoserine332 def: "Protein ASPP1_HUMAN with the residue 332 substituted with Phosphoserine" [UniProtKB:Q96KQ4] comment: By similarity xref: UniProtKB:Q96KQ4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0002046 ! ASPP1_HUMAN [Term] id: CCO:B0010629 name: ASPP1_HUMAN-Phosphoserine335 def: "Protein ASPP1_HUMAN with the residue 335 substituted with Phosphoserine" [UniProtKB:Q96KQ4] comment: By similarity xref: UniProtKB:Q96KQ4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002046 ! ASPP1_HUMAN [Term] id: CCO:B0010630 name: ASPP1_HUMAN-Phosphoserine671 def: "Protein ASPP1_HUMAN with the residue 671 substituted with Phosphoserine" [UniProtKB:Q96KQ4] comment: By similarity xref: UniProtKB:Q96KQ4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002046 ! ASPP1_HUMAN [Term] id: CCO:B0010631 name: ASPP2_HUMAN-Phosphoserine480 def: "Protein ASPP2_HUMAN with the residue 480 substituted with Phosphoserine" [UniProtKB:Q13625] comment: By similarity xref: UniProtKB:Q13625 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001764 ! ASPP2_HUMAN [Term] id: CCO:B0010632 name: ASPP2_HUMAN-Phosphoserine698 def: "Protein ASPP2_HUMAN with the residue 698 substituted with Phosphoserine" [UniProtKB:Q13625] xref: UniProtKB:Q13625 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001764 ! ASPP2_HUMAN [Term] id: CCO:B0010633 name: AT1A1_HUMAN-Phosphotyrosine10 def: "Protein AT1A1_HUMAN with the residue 10 substituted with Phosphotyrosine" [UniProtKB:P05023] comment: By similarity xref: UniProtKB:P05023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005459 ! AT1A1_HUMAN [Term] id: CCO:B0010634 name: AT1A1_HUMAN-Phosphoserine16 def: "Protein AT1A1_HUMAN with the residue 16 substituted with Phosphoserine" [UniProtKB:P05023] comment: by PKC; By similarity xref: UniProtKB:P05023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005459 ! AT1A1_HUMAN [Term] id: CCO:B0010635 name: AT1A1_HUMAN-Phosphoserine47 def: "Protein AT1A1_HUMAN with the residue 47 substituted with Phosphoserine" [UniProtKB:P05023] comment: By similarity xref: UniProtKB:P05023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005459 ! AT1A1_HUMAN [Term] id: CCO:B0010636 name: AT1A1_HUMAN-Phosphoserine217 def: "Protein AT1A1_HUMAN with the residue 217 substituted with Phosphoserine" [UniProtKB:P05023] comment: By similarity xref: UniProtKB:P05023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005459 ! AT1A1_HUMAN [Term] id: CCO:B0010637 name: AT1A1_HUMAN-Phosphothreonine219 def: "Protein AT1A1_HUMAN with the residue 219 substituted with Phosphothreonine" [UniProtKB:P05023] comment: By similarity xref: UniProtKB:P05023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005459 ! AT1A1_HUMAN [Term] id: CCO:B0010638 name: AT1A1_HUMAN-Phosphoserine228 def: "Protein AT1A1_HUMAN with the residue 228 substituted with Phosphoserine" [UniProtKB:P05023] comment: By similarity xref: UniProtKB:P05023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005459 ! AT1A1_HUMAN [Term] id: CCO:B0010639 name: AT1A1_HUMAN-Phosphoserine452 def: "Protein AT1A1_HUMAN with the residue 452 substituted with Phosphoserine" [UniProtKB:P05023] comment: By similarity xref: UniProtKB:P05023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005459 ! AT1A1_HUMAN [Term] id: CCO:B0010640 name: AT1A1_HUMAN-Phosphoserine943 def: "Protein AT1A1_HUMAN with the residue 943 substituted with Phosphoserine" [UniProtKB:P05023] comment: by PKA; By similarity xref: UniProtKB:P05023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005459 ! AT1A1_HUMAN [Term] id: CCO:B0010641 name: AT2A2_HUMAN-Phosphothreonine537 def: "Protein AT2A2_HUMAN with the residue 537 substituted with Phosphothreonine" [UniProtKB:P16615] comment: By similarity xref: UniProtKB:P16615 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005840 ! AT2A2_HUMAN [Term] id: CCO:B0010642 name: AT2A2_HUMAN-Phosphoserine663 def: "Protein AT2A2_HUMAN with the residue 663 substituted with Phosphoserine" [UniProtKB:P16615] xref: UniProtKB:P16615 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005840 ! AT2A2_HUMAN [Term] id: CCO:B0010643 name: ATF7_HUMAN-Phosphothreonine51 def: "Protein ATF7_HUMAN with the residue 51 substituted with Phosphothreonine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010644 name: ATF7_HUMAN-Phosphothreonine53 def: "Protein ATF7_HUMAN with the residue 53 substituted with Phosphothreonine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010645 name: ATF7_HUMAN-Phosphoserine111 def: "Protein ATF7_HUMAN with the residue 111 substituted with Phosphoserine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010646 name: ATF7_HUMAN-Phosphothreonine112 def: "Protein ATF7_HUMAN with the residue 112 substituted with Phosphothreonine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010647 name: ATF7_HUMAN-Phosphoserine127 def: "Protein ATF7_HUMAN with the residue 127 substituted with Phosphoserine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010648 name: ATF7_HUMAN-Phosphoserine128 def: "Protein ATF7_HUMAN with the residue 128 substituted with Phosphoserine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010649 name: ATF7_HUMAN-Phosphoserine132 def: "Protein ATF7_HUMAN with the residue 132 substituted with Phosphoserine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010650 name: ATF7_HUMAN-Phosphoserine135 def: "Protein ATF7_HUMAN with the residue 135 substituted with Phosphoserine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010651 name: ATF7_HUMAN-Phosphoserine136 def: "Protein ATF7_HUMAN with the residue 136 substituted with Phosphoserine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010652 name: ATF7_HUMAN-Phosphoserine139 def: "Protein ATF7_HUMAN with the residue 139 substituted with Phosphoserine" [UniProtKB:P17544] xref: UniProtKB:P17544 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006016 ! ATF7_HUMAN [Term] id: CCO:B0010653 name: ATM_HUMAN-Phosphothreonine72 def: "Protein ATM_HUMAN with the residue 72 substituted with Phosphothreonine" [UniProtKB:Q13315] xref: UniProtKB:Q13315 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003115 ! 1-phosphatidylinositol-3-kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor relationship: has_function CCO:F0006791 ! protein N-terminus binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0001235 ! cytoplasmic vesicle relationship: transformation_of CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:B0010654 name: ATM_HUMAN-Phosphoserine85 def: "Protein ATM_HUMAN with the residue 85 substituted with Phosphoserine" [UniProtKB:Q13315] xref: UniProtKB:Q13315 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:B0010655 name: ATM_HUMAN-Phosphothreonine86 def: "Protein ATM_HUMAN with the residue 86 substituted with Phosphothreonine" [UniProtKB:Q13315] xref: UniProtKB:Q13315 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:B0010656 name: ATM_HUMAN-Phosphoserine367 def: "Protein ATM_HUMAN with the residue 367 substituted with Phosphoserine" [UniProtKB:Q13315] xref: UniProtKB:Q13315 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:B0010657 name: ATM_HUMAN-Phosphothreonine373 def: "Protein ATM_HUMAN with the residue 373 substituted with Phosphothreonine" [UniProtKB:Q13315] xref: UniProtKB:Q13315 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:B0010658 name: ATM_HUMAN-Phosphoserine1981 def: "Protein ATM_HUMAN with the residue 1981 substituted with Phosphoserine" [UniProtKB:Q13315] comment: by autocatalysis; xref: UniProtKB:Q13315 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:B0010659 name: ATM_HUMAN-Phosphothreonine1985 def: "Protein ATM_HUMAN with the residue 1985 substituted with Phosphothreonine" [UniProtKB:Q13315] xref: UniProtKB:Q13315 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:B0010660 name: ATN1_HUMAN-Phosphoserine34 def: "Protein ATN1_HUMAN with the residue 34 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010661 name: ATN1_HUMAN-Phosphoserine77 def: "Protein ATN1_HUMAN with the residue 77 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010662 name: ATN1_HUMAN-Phosphoserine79 def: "Protein ATN1_HUMAN with the residue 79 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010663 name: ATN1_HUMAN-Phosphoserine101 def: "Protein ATN1_HUMAN with the residue 101 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010664 name: ATN1_HUMAN-Phosphoserine103 def: "Protein ATN1_HUMAN with the residue 103 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010665 name: ATN1_HUMAN-Phosphoserine107 def: "Protein ATN1_HUMAN with the residue 107 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010666 name: ATN1_HUMAN-Phosphoserine112 def: "Protein ATN1_HUMAN with the residue 112 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010667 name: ATN1_HUMAN-Phosphoserine119 def: "Protein ATN1_HUMAN with the residue 119 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010668 name: ATN1_HUMAN-Phosphoserine627 def: "Protein ATN1_HUMAN with the residue 627 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010669 name: ATN1_HUMAN-Phosphoserine640 def: "Protein ATN1_HUMAN with the residue 640 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010670 name: ATN1_HUMAN-Phosphothreonine648 def: "Protein ATN1_HUMAN with the residue 648 substituted with Phosphothreonine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010671 name: ATN1_HUMAN-Phosphoserine656 def: "Protein ATN1_HUMAN with the residue 656 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010672 name: ATN1_HUMAN-Phosphothreonine664 def: "Protein ATN1_HUMAN with the residue 664 substituted with Phosphothreonine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010673 name: ATN1_HUMAN-Phosphoserine734 def: "Protein ATN1_HUMAN with the residue 734 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010674 name: ATN1_HUMAN-Phosphoserine741 def: "Protein ATN1_HUMAN with the residue 741 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010675 name: ATN1_HUMAN-Phosphoserine743 def: "Protein ATN1_HUMAN with the residue 743 substituted with Phosphoserine" [UniProtKB:P54259] xref: UniProtKB:P54259 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:B0010676 name: ATPA_HUMAN-Pyrrolidone carboxylic acid44 def: "Protein ATPA_HUMAN with the residue 44 substituted with Pyrrolidone carboxylic acid" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010677 name: ATPA_HUMAN-Phosphoserine76 def: "Protein ATPA_HUMAN with the residue 76 substituted with Phosphoserine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010678 name: ATPA_HUMAN-N6-acetyllysine132 def: "Protein ATPA_HUMAN with the residue 132 substituted with N6-acetyllysine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010679 name: ATPA_HUMAN-N6-acetyllysine230 def: "Protein ATPA_HUMAN with the residue 230 substituted with N6-acetyllysine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010680 name: ATPA_HUMAN-N6-acetyllysine239 def: "Protein ATPA_HUMAN with the residue 239 substituted with N6-acetyllysine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010681 name: ATPA_HUMAN-N6-acetyllysine261 def: "Protein ATPA_HUMAN with the residue 261 substituted with N6-acetyllysine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010682 name: ATPA_HUMAN-N6-acetyllysine305 def: "Protein ATPA_HUMAN with the residue 305 substituted with N6-acetyllysine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010683 name: ATPA_HUMAN-N6-acetyllysine427 def: "Protein ATPA_HUMAN with the residue 427 substituted with N6-acetyllysine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010684 name: ATPA_HUMAN-N6-acetyllysine498 def: "Protein ATPA_HUMAN with the residue 498 substituted with N6-acetyllysine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010685 name: ATPA_HUMAN-N6-acetyllysine531 def: "Protein ATPA_HUMAN with the residue 531 substituted with N6-acetyllysine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010686 name: ATPA_HUMAN-N6-acetyllysine539 def: "Protein ATPA_HUMAN with the residue 539 substituted with N6-acetyllysine" [UniProtKB:P25705] comment: By similarity xref: UniProtKB:P25705 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005778 ! ATPA_HUMAN [Term] id: CCO:B0010687 name: ATPB_HUMAN-N6-acetyllysine133 def: "Protein ATPB_HUMAN with the residue 133 substituted with N6-acetyllysine" [UniProtKB:P06576] comment: By similarity xref: UniProtKB:P06576 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005827 ! ATPB_HUMAN [Term] id: CCO:B0010688 name: ATPB_HUMAN-N6-acetyllysine259 def: "Protein ATPB_HUMAN with the residue 259 substituted with N6-acetyllysine" [UniProtKB:P06576] comment: By similarity xref: UniProtKB:P06576 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005827 ! ATPB_HUMAN [Term] id: CCO:B0010689 name: ATPB_HUMAN-N6-acetyllysine522 def: "Protein ATPB_HUMAN with the residue 522 substituted with N6-acetyllysine" [UniProtKB:P06576] comment: By similarity xref: UniProtKB:P06576 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005827 ! ATPB_HUMAN [Term] id: CCO:B0010690 name: ATPB_HUMAN-Phosphoserine529 def: "Protein ATPB_HUMAN with the residue 529 substituted with Phosphoserine" [UniProtKB:P06576] comment: By similarity xref: UniProtKB:P06576 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005827 ! ATPB_HUMAN [Term] id: CCO:B0010691 name: ATPG_HUMAN-N6-acetyllysine79 def: "Protein ATPG_HUMAN with the residue 79 substituted with N6-acetyllysine" [UniProtKB:P36542] comment: By similarity xref: UniProtKB:P36542 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006122 ! ATPG_HUMAN [Term] id: CCO:B0010692 name: ATPG_HUMAN-N6-acetyllysine90 def: "Protein ATPG_HUMAN with the residue 90 substituted with N6-acetyllysine" [UniProtKB:P36542] comment: By similarity xref: UniProtKB:P36542 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006122 ! ATPG_HUMAN [Term] id: CCO:B0010693 name: ATPG_HUMAN-N6-acetyllysine115 def: "Protein ATPG_HUMAN with the residue 115 substituted with N6-acetyllysine" [UniProtKB:P36542] comment: By similarity xref: UniProtKB:P36542 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006122 ! ATPG_HUMAN [Term] id: CCO:B0010694 name: ATRIP_HUMAN-Phosphoserine518 def: "Protein ATRIP_HUMAN with the residue 518 substituted with Phosphoserine" [UniProtKB:Q8WXE1] xref: UniProtKB:Q8WXE1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002009 ! ATRIP_HUMAN [Term] id: CCO:B0010695 name: ATRX_HUMAN-Phosphoserine34 def: "Protein ATRX_HUMAN with the residue 34 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010696 name: ATRX_HUMAN-Phosphoserine71 def: "Protein ATRX_HUMAN with the residue 71 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010697 name: ATRX_HUMAN-Phosphoserine74 def: "Protein ATRX_HUMAN with the residue 74 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010698 name: ATRX_HUMAN-Phosphothreonine87 def: "Protein ATRX_HUMAN with the residue 87 substituted with Phosphothreonine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010699 name: ATRX_HUMAN-Phosphoserine92 def: "Protein ATRX_HUMAN with the residue 92 substituted with Phosphoserine" [UniProtKB:P46100] comment: By similarity xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010700 name: ATRX_HUMAN-Phosphoserine634 def: "Protein ATRX_HUMAN with the residue 634 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010701 name: ATRX_HUMAN-Phosphoserine729 def: "Protein ATRX_HUMAN with the residue 729 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010702 name: ATRX_HUMAN-Phosphoserine731 def: "Protein ATRX_HUMAN with the residue 731 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010703 name: ATRX_HUMAN-Phosphoserine849 def: "Protein ATRX_HUMAN with the residue 849 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010704 name: ATRX_HUMAN-Phosphoserine850 def: "Protein ATRX_HUMAN with the residue 850 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010705 name: ATRX_HUMAN-Phosphoserine871 def: "Protein ATRX_HUMAN with the residue 871 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010706 name: ATRX_HUMAN-Phosphoserine1348 def: "Protein ATRX_HUMAN with the residue 1348 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010707 name: ATRX_HUMAN-Phosphoserine1352 def: "Protein ATRX_HUMAN with the residue 1352 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010708 name: ATRX_HUMAN-Phosphoserine1527 def: "Protein ATRX_HUMAN with the residue 1527 substituted with Phosphoserine" [UniProtKB:P46100] xref: UniProtKB:P46100 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:B0010709 name: ATR_HUMAN-Phosphoserine919 def: "Protein ATR_HUMAN with the residue 919 substituted with Phosphoserine" [UniProtKB:Q13535] xref: UniProtKB:Q13535 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001756 ! ATR_HUMAN [Term] id: CCO:B0010710 name: ATX2_HUMAN-Phosphoserine643 def: "Protein ATX2_HUMAN with the residue 643 substituted with Phosphoserine" [UniProtKB:Q99700] comment: By similarity xref: UniProtKB:Q99700 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:B0010711 name: ATX2_HUMAN-Phosphoserine683 def: "Protein ATX2_HUMAN with the residue 683 substituted with Phosphoserine" [UniProtKB:Q99700] comment: By similarity xref: UniProtKB:Q99700 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:B0010712 name: ATX2_HUMAN-Phosphothreonine770 def: "Protein ATX2_HUMAN with the residue 770 substituted with Phosphothreonine" [UniProtKB:Q99700] xref: UniProtKB:Q99700 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:B0010713 name: ATX2_HUMAN-Phosphoserine771 def: "Protein ATX2_HUMAN with the residue 771 substituted with Phosphoserine" [UniProtKB:Q99700] xref: UniProtKB:Q99700 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:B0010714 name: ATX2_HUMAN-Phosphoserine775 def: "Protein ATX2_HUMAN with the residue 775 substituted with Phosphoserine" [UniProtKB:Q99700] xref: UniProtKB:Q99700 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:B0010715 name: ATX2_HUMAN-Phosphoserine827 def: "Protein ATX2_HUMAN with the residue 827 substituted with Phosphoserine" [UniProtKB:Q99700] xref: UniProtKB:Q99700 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:B0010716 name: ATX2_HUMAN-Phosphoserine838 def: "Protein ATX2_HUMAN with the residue 838 substituted with Phosphoserine" [UniProtKB:Q99700] xref: UniProtKB:Q99700 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:B0010717 name: ATX2_HUMAN-Phosphoserine860 def: "Protein ATX2_HUMAN with the residue 860 substituted with Phosphoserine" [UniProtKB:Q99700] comment: By similarity xref: UniProtKB:Q99700 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:B0010718 name: ATX2_HUMAN-Phosphoserine864 def: "Protein ATX2_HUMAN with the residue 864 substituted with Phosphoserine" [UniProtKB:Q99700] comment: By similarity xref: UniProtKB:Q99700 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:B0010719 name: ATX7_HUMAN-Phosphoserine840 def: "Protein ATX7_HUMAN with the residue 840 substituted with Phosphoserine" [UniProtKB:O15265] xref: UniProtKB:O15265 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005945 ! ATX7_HUMAN [Term] id: CCO:B0010720 name: ATX7_HUMAN-Phosphoserine849 def: "Protein ATX7_HUMAN with the residue 849 substituted with Phosphoserine" [UniProtKB:O15265] xref: UniProtKB:O15265 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005945 ! ATX7_HUMAN [Term] id: CCO:B0010721 name: ATX7_HUMAN-Phosphothreonine854 def: "Protein ATX7_HUMAN with the residue 854 substituted with Phosphothreonine" [UniProtKB:O15265] xref: UniProtKB:O15265 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005945 ! ATX7_HUMAN [Term] id: CCO:B0010722 name: AURKB_HUMAN-Phosphoserine7 def: "Protein AURKB_HUMAN with the residue 7 substituted with Phosphoserine" [UniProtKB:Q96GD4] xref: UniProtKB:Q96GD4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:B0010723 name: AURKB_HUMAN-Phosphotyrosine12 def: "Protein AURKB_HUMAN with the residue 12 substituted with Phosphotyrosine" [UniProtKB:Q96GD4] xref: UniProtKB:Q96GD4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:B0010724 name: AURKB_HUMAN-Phosphothreonine232 def: "Protein AURKB_HUMAN with the residue 232 substituted with Phosphothreonine" [UniProtKB:Q96GD4] xref: UniProtKB:Q96GD4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:B0010729 name: BAT2_HUMAN-Phosphoserine114 def: "Protein BAT2_HUMAN with the residue 114 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010730 name: BAT2_HUMAN-Phosphoserine204 def: "Protein BAT2_HUMAN with the residue 204 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010731 name: BAT2_HUMAN-Phosphoserine342 def: "Protein BAT2_HUMAN with the residue 342 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010732 name: BAT2_HUMAN-Phosphoserine350 def: "Protein BAT2_HUMAN with the residue 350 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010733 name: BAT2_HUMAN-Phosphoserine380 def: "Protein BAT2_HUMAN with the residue 380 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010734 name: BAT2_HUMAN-Phosphoserine456 def: "Protein BAT2_HUMAN with the residue 456 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010735 name: BAT2_HUMAN-Phosphothreonine517 def: "Protein BAT2_HUMAN with the residue 517 substituted with Phosphothreonine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010736 name: BAT2_HUMAN-Phosphothreonine610 def: "Protein BAT2_HUMAN with the residue 610 substituted with Phosphothreonine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010737 name: BAT2_HUMAN-Phosphoserine759 def: "Protein BAT2_HUMAN with the residue 759 substituted with Phosphoserine" [UniProtKB:P48634] comment: By similarity xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010738 name: BAT2_HUMAN-Phosphoserine761 def: "Protein BAT2_HUMAN with the residue 761 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010739 name: BAT2_HUMAN-Phosphoserine764 def: "Protein BAT2_HUMAN with the residue 764 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010740 name: BAT2_HUMAN-Phosphothreonine782 def: "Protein BAT2_HUMAN with the residue 782 substituted with Phosphothreonine" [UniProtKB:P48634] comment: By similarity xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010741 name: BAT2_HUMAN-Phosphoserine1004 def: "Protein BAT2_HUMAN with the residue 1004 substituted with Phosphoserine" [UniProtKB:P48634] comment: By similarity xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010742 name: BAT2_HUMAN-Phosphoserine1089 def: "Protein BAT2_HUMAN with the residue 1089 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010743 name: BAT2_HUMAN-Phosphoserine1092 def: "Protein BAT2_HUMAN with the residue 1092 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010744 name: BAT2_HUMAN-Phosphoserine1219 def: "Protein BAT2_HUMAN with the residue 1219 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010745 name: BAT2_HUMAN-Phosphothreonine1347 def: "Protein BAT2_HUMAN with the residue 1347 substituted with Phosphothreonine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010746 name: BAT2_HUMAN-Phosphothreonine1353 def: "Protein BAT2_HUMAN with the residue 1353 substituted with Phosphothreonine" [UniProtKB:P48634] comment: By similarity xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0010747 name: BAT3_HUMAN-Phosphoserine113 def: "Protein BAT3_HUMAN with the residue 113 substituted with Phosphoserine" [UniProtKB:P46379] xref: UniProtKB:P46379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006127 ! BAT3_HUMAN [Term] id: CCO:B0010748 name: BAT3_HUMAN-Phosphoserine964 def: "Protein BAT3_HUMAN with the residue 964 substituted with Phosphoserine" [UniProtKB:P46379] xref: UniProtKB:P46379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006127 ! BAT3_HUMAN [Term] id: CCO:B0010749 name: BAT3_HUMAN-Phosphoserine973 def: "Protein BAT3_HUMAN with the residue 973 substituted with Phosphoserine" [UniProtKB:P46379] xref: UniProtKB:P46379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006127 ! BAT3_HUMAN [Term] id: CCO:B0010750 name: BAT3_HUMAN-Phosphoserine1039 def: "Protein BAT3_HUMAN with the residue 1039 substituted with Phosphoserine" [UniProtKB:P46379] xref: UniProtKB:P46379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006127 ! BAT3_HUMAN [Term] id: CCO:B0010751 name: BAT3_HUMAN-Phosphotyrosine1042 def: "Protein BAT3_HUMAN with the residue 1042 substituted with Phosphotyrosine" [UniProtKB:P46379] xref: UniProtKB:P46379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006127 ! BAT3_HUMAN [Term] id: CCO:B0010752 name: BAT3_HUMAN-Phosphoserine1117 def: "Protein BAT3_HUMAN with the residue 1117 substituted with Phosphoserine" [UniProtKB:P46379] xref: UniProtKB:P46379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006127 ! BAT3_HUMAN [Term] id: CCO:B0010753 name: BCAR1_HUMAN-Phosphotyrosine128 def: "Protein BCAR1_HUMAN with the residue 128 substituted with Phosphotyrosine" [UniProtKB:P56945] xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010754 name: BCAR1_HUMAN-Phosphoserine139 def: "Protein BCAR1_HUMAN with the residue 139 substituted with Phosphoserine" [UniProtKB:P56945] xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010755 name: BCAR1_HUMAN-Phosphotyrosine222 def: "Protein BCAR1_HUMAN with the residue 222 substituted with Phosphotyrosine" [UniProtKB:P56945] xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010756 name: BCAR1_HUMAN-Phosphotyrosine224 def: "Protein BCAR1_HUMAN with the residue 224 substituted with Phosphotyrosine" [UniProtKB:P56945] xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010757 name: BCAR1_HUMAN-Phosphotyrosine234 def: "Protein BCAR1_HUMAN with the residue 234 substituted with Phosphotyrosine" [UniProtKB:P56945] xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010758 name: BCAR1_HUMAN-Phosphotyrosine249 def: "Protein BCAR1_HUMAN with the residue 249 substituted with Phosphotyrosine" [UniProtKB:P56945] xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010759 name: BCAR1_HUMAN-Phosphotyrosine327 def: "Protein BCAR1_HUMAN with the residue 327 substituted with Phosphotyrosine" [UniProtKB:P56945] xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010760 name: BCAR1_HUMAN-Phosphotyrosine362 def: "Protein BCAR1_HUMAN with the residue 362 substituted with Phosphotyrosine" [UniProtKB:P56945] comment: By similarity xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010761 name: BCAR1_HUMAN-Phosphotyrosine387 def: "Protein BCAR1_HUMAN with the residue 387 substituted with Phosphotyrosine" [UniProtKB:P56945] xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010762 name: BCAR1_HUMAN-Phosphotyrosine410 def: "Protein BCAR1_HUMAN with the residue 410 substituted with Phosphotyrosine" [UniProtKB:P56945] comment: By similarity xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010763 name: BCAR1_HUMAN-Phosphoserine639 def: "Protein BCAR1_HUMAN with the residue 639 substituted with Phosphoserine" [UniProtKB:P56945] xref: UniProtKB:P56945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:B0010764 name: BCAR3_HUMAN-Phosphothreonine130 def: "Protein BCAR3_HUMAN with the residue 130 substituted with Phosphothreonine" [UniProtKB:O75815] xref: UniProtKB:O75815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001437 ! BCAR3_HUMAN [Term] id: CCO:B0010765 name: BCAR3_HUMAN-Phosphoserine182 def: "Protein BCAR3_HUMAN with the residue 182 substituted with Phosphoserine" [UniProtKB:O75815] xref: UniProtKB:O75815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001437 ! BCAR3_HUMAN [Term] id: CCO:B0010766 name: BCAR3_HUMAN-Phosphoserine290 def: "Protein BCAR3_HUMAN with the residue 290 substituted with Phosphoserine" [UniProtKB:O75815] xref: UniProtKB:O75815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001437 ! BCAR3_HUMAN [Term] id: CCO:B0010767 name: BCAR3_HUMAN-Phosphoserine370 def: "Protein BCAR3_HUMAN with the residue 370 substituted with Phosphoserine" [UniProtKB:O75815] comment: By similarity xref: UniProtKB:O75815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001437 ! BCAR3_HUMAN [Term] id: CCO:B0010768 name: BCAR3_HUMAN-Phosphoserine375 def: "Protein BCAR3_HUMAN with the residue 375 substituted with Phosphoserine" [UniProtKB:O75815] xref: UniProtKB:O75815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001437 ! BCAR3_HUMAN [Term] id: CCO:B0010769 name: BCCIP_HUMAN-Phosphoserine12 def: "Protein BCCIP_HUMAN with the residue 12 substituted with Phosphoserine" [UniProtKB:Q9P287] xref: UniProtKB:Q9P287 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002187 ! BCCIP_HUMAN [Term] id: CCO:B0010770 name: BCCIP_HUMAN-Phosphoserine42 def: "Protein BCCIP_HUMAN with the residue 42 substituted with Phosphoserine" [UniProtKB:Q9P287] xref: UniProtKB:Q9P287 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002187 ! BCCIP_HUMAN [Term] id: CCO:B0010771 name: BCCIP_HUMAN-Phosphoserine112 def: "Protein BCCIP_HUMAN with the residue 112 substituted with Phosphoserine" [UniProtKB:Q9P287] xref: UniProtKB:Q9P287 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: transformation_of CCO:B0002187 ! BCCIP_HUMAN [Term] id: CCO:B0010772 name: BCCIP_HUMAN-Phosphoserine115 def: "Protein BCCIP_HUMAN with the residue 115 substituted with Phosphoserine" [UniProtKB:Q9P287] xref: UniProtKB:Q9P287 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002187 ! BCCIP_HUMAN [Term] id: CCO:B0010773 name: BCL2_HUMAN-Phosphoserine70 def: "Protein BCL2_HUMAN with the residue 70 substituted with Phosphoserine" [UniProtKB:P10415] comment: by PKC; By similarity xref: UniProtKB:P10415 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001506 ! BCL2_HUMAN [Term] id: CCO:B0010774 name: BCL9_HUMAN-Phosphothreonine315 def: "Protein BCL9_HUMAN with the residue 315 substituted with Phosphothreonine" [UniProtKB:O00512] xref: UniProtKB:O00512 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006061 ! BCL9_HUMAN [Term] id: CCO:B0010775 name: BCL9_HUMAN-Phosphoserine318 def: "Protein BCL9_HUMAN with the residue 318 substituted with Phosphoserine" [UniProtKB:O00512] xref: UniProtKB:O00512 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006061 ! BCL9_HUMAN [Term] id: CCO:B0010776 name: BCL9_HUMAN-Phosphoserine352 def: "Protein BCL9_HUMAN with the residue 352 substituted with Phosphoserine" [UniProtKB:O00512] comment: By similarity xref: UniProtKB:O00512 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006061 ! BCL9_HUMAN [Term] id: CCO:B0010777 name: BCL9_HUMAN-Phosphoserine687 def: "Protein BCL9_HUMAN with the residue 687 substituted with Phosphoserine" [UniProtKB:O00512] xref: UniProtKB:O00512 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006061 ! BCL9_HUMAN [Term] id: CCO:B0010778 name: BCR_HUMAN-Phosphotyrosine177 def: "Protein BCR_HUMAN with the residue 177 substituted with Phosphotyrosine" [UniProtKB:P11274] xref: UniProtKB:P11274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:B0010779 name: BCR_HUMAN-Phosphothreonine310 def: "Protein BCR_HUMAN with the residue 310 substituted with Phosphothreonine" [UniProtKB:P11274] xref: UniProtKB:P11274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:B0010780 name: BCR_HUMAN-Phosphoserine459 def: "Protein BCR_HUMAN with the residue 459 substituted with Phosphoserine" [UniProtKB:P11274] xref: UniProtKB:P11274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:B0010781 name: BCR_HUMAN-Phosphoserine463 def: "Protein BCR_HUMAN with the residue 463 substituted with Phosphoserine" [UniProtKB:P11274] xref: UniProtKB:P11274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:B0010782 name: BCR_HUMAN-Phosphotyrosine591 def: "Protein BCR_HUMAN with the residue 591 substituted with Phosphotyrosine" [UniProtKB:P11274] xref: UniProtKB:P11274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:B0010783 name: BCR_HUMAN-Phosphotyrosine644 def: "Protein BCR_HUMAN with the residue 644 substituted with Phosphotyrosine" [UniProtKB:P11274] xref: UniProtKB:P11274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:B0010784 name: BCR_HUMAN-Phosphoserine1264 def: "Protein BCR_HUMAN with the residue 1264 substituted with Phosphoserine" [UniProtKB:P11274] xref: UniProtKB:P11274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:B0010785 name: BEGIN_HUMAN-Phosphoserine194 def: "Protein BEGIN_HUMAN with the residue 194 substituted with Phosphoserine" [UniProtKB:Q9BUH8] comment: By similarity xref: UniProtKB:Q9BUH8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:B0010786 name: BEGIN_HUMAN-Phosphoserine246 def: "Protein BEGIN_HUMAN with the residue 246 substituted with Phosphoserine" [UniProtKB:Q9BUH8] xref: UniProtKB:Q9BUH8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:B0010787 name: BEGIN_HUMAN-Phosphoserine265 def: "Protein BEGIN_HUMAN with the residue 265 substituted with Phosphoserine" [UniProtKB:Q9BUH8] comment: By similarity xref: UniProtKB:Q9BUH8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:B0010788 name: BEGIN_HUMAN-Phosphoserine465 def: "Protein BEGIN_HUMAN with the residue 465 substituted with Phosphoserine" [UniProtKB:Q9BUH8] comment: By similarity xref: UniProtKB:Q9BUH8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:B0010789 name: BEGIN_HUMAN-Phosphoserine483 def: "Protein BEGIN_HUMAN with the residue 483 substituted with Phosphoserine" [UniProtKB:Q9BUH8] xref: UniProtKB:Q9BUH8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:B0010790 name: BEGIN_HUMAN-Phosphoserine502 def: "Protein BEGIN_HUMAN with the residue 502 substituted with Phosphoserine" [UniProtKB:Q9BUH8] xref: UniProtKB:Q9BUH8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:B0010791 name: BEGIN_HUMAN-Phosphoserine563 def: "Protein BEGIN_HUMAN with the residue 563 substituted with Phosphoserine" [UniProtKB:Q9BUH8] xref: UniProtKB:Q9BUH8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:B0010794 name: BIN1_HUMAN-Phosphoserine296 def: "Protein BIN1_HUMAN with the residue 296 substituted with Phosphoserine" [UniProtKB:O00499] xref: UniProtKB:O00499 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001349 ! BIN1_HUMAN [Term] id: CCO:B0010795 name: BIN1_HUMAN-Phosphoserine298 def: "Protein BIN1_HUMAN with the residue 298 substituted with Phosphoserine" [UniProtKB:O00499] xref: UniProtKB:O00499 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001349 ! BIN1_HUMAN [Term] id: CCO:B0010796 name: BIN1_HUMAN-Phosphoserine303 def: "Protein BIN1_HUMAN with the residue 303 substituted with Phosphoserine" [UniProtKB:O00499] xref: UniProtKB:O00499 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001349 ! BIN1_HUMAN [Term] id: CCO:B0010797 name: BIN1_HUMAN-Phosphothreonine307 def: "Protein BIN1_HUMAN with the residue 307 substituted with Phosphothreonine" [UniProtKB:O00499] comment: By similarity xref: UniProtKB:O00499 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001349 ! BIN1_HUMAN [Term] id: CCO:B0010798 name: BIN1_HUMAN-Phosphoserine331 def: "Protein BIN1_HUMAN with the residue 331 substituted with Phosphoserine" [UniProtKB:O00499] xref: UniProtKB:O00499 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001349 ! BIN1_HUMAN [Term] id: CCO:B0010799 name: BIRC5_HUMAN-Phosphothreonine34 def: "Protein BIRC5_HUMAN with the residue 34 substituted with Phosphothreonine" [UniProtKB:O15392] comment: by CDC2; xref: UniProtKB:O15392 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001377 ! BIRC5_HUMAN [Term] id: CCO:B0010800 name: BLM_HUMAN-Phosphoserine419 def: "Protein BLM_HUMAN with the residue 419 substituted with Phosphoserine" [UniProtKB:P54132] xref: UniProtKB:P54132 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000087 ! bubble DNA binding relationship: has_function CCO:F0000099 ! DNA strand annealing activity relationship: has_function CCO:F0000257 ! p53 binding relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000288 ! single-stranded DNA binding relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0000487 ! ATP-dependent DNA helicase activity relationship: has_function CCO:F0000803 ! helicase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001682 ! ATP-dependent helicase activity relationship: has_function CCO:F0002383 ! four-way junction helicase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0003386 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides relationship: has_function CCO:F0003445 ! ATPase activity relationship: has_function CCO:F0008203 ! G-quadruplex DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000108 ! chromosome, telomeric region relationship: located_in CCO:C0000127 ! lateral element relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000320 ! nucleolus relationship: located_in CCO:C0000785 ! nuclear matrix relationship: located_in CCO:C0000818 ! PML body relationship: transformation_of CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:B0010801 name: BLM_HUMAN-Phosphoserine422 def: "Protein BLM_HUMAN with the residue 422 substituted with Phosphoserine" [UniProtKB:P54132] xref: UniProtKB:P54132 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:B0010802 name: BLM_HUMAN-Phosphoserine480 def: "Protein BLM_HUMAN with the residue 480 substituted with Phosphoserine" [UniProtKB:P54132] xref: UniProtKB:P54132 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:B0010803 name: BLM_HUMAN-Phosphoserine499 def: "Protein BLM_HUMAN with the residue 499 substituted with Phosphoserine" [UniProtKB:P54132] xref: UniProtKB:P54132 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:B0010804 name: BLM_HUMAN-Phosphothreonine508 def: "Protein BLM_HUMAN with the residue 508 substituted with Phosphothreonine" [UniProtKB:P54132] xref: UniProtKB:P54132 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:B0010805 name: BLM_HUMAN-Phosphoserine1296 def: "Protein BLM_HUMAN with the residue 1296 substituted with Phosphoserine" [UniProtKB:P54132] xref: UniProtKB:P54132 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:B0010806 name: BMCC1_HUMAN-Phosphoserine217 def: "Protein BMCC1_HUMAN with the residue 217 substituted with Phosphoserine" [UniProtKB:Q58A63] xref: UniProtKB:Q58A63 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001842 ! BMCC1_HUMAN [Term] id: CCO:B0010807 name: BMCC1_HUMAN-Phosphoserine227 def: "Protein BMCC1_HUMAN with the residue 227 substituted with Phosphoserine" [UniProtKB:Q58A63] xref: UniProtKB:Q58A63 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001842 ! BMCC1_HUMAN [Term] id: CCO:B0010808 name: BMCC1_HUMAN-Phosphoserine236 def: "Protein BMCC1_HUMAN with the residue 236 substituted with Phosphoserine" [UniProtKB:Q58A63] xref: UniProtKB:Q58A63 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001842 ! BMCC1_HUMAN [Term] id: CCO:B0010809 name: BMCC1_HUMAN-Phosphoserine238 def: "Protein BMCC1_HUMAN with the residue 238 substituted with Phosphoserine" [UniProtKB:Q58A63] xref: UniProtKB:Q58A63 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001842 ! BMCC1_HUMAN [Term] id: CCO:B0010810 name: BMCC1_HUMAN-Phosphoserine340 def: "Protein BMCC1_HUMAN with the residue 340 substituted with Phosphoserine" [UniProtKB:Q58A63] xref: UniProtKB:Q58A63 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001842 ! BMCC1_HUMAN [Term] id: CCO:B0010811 name: BMR1A_HUMAN-Phosphoserine215 def: "Protein BMR1A_HUMAN with the residue 215 substituted with Phosphoserine" [UniProtKB:P36894] xref: UniProtKB:P36894 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005437 ! BMR1A_HUMAN [Term] id: CCO:B0010812 name: BMR1A_HUMAN-Phosphoserine216 def: "Protein BMR1A_HUMAN with the residue 216 substituted with Phosphoserine" [UniProtKB:P36894] xref: UniProtKB:P36894 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005437 ! BMR1A_HUMAN [Term] id: CCO:B0010813 name: BMR1A_HUMAN-Phosphoserine218 def: "Protein BMR1A_HUMAN with the residue 218 substituted with Phosphoserine" [UniProtKB:P36894] xref: UniProtKB:P36894 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005437 ! BMR1A_HUMAN [Term] id: CCO:B0010814 name: BMR1A_HUMAN-Phosphoserine220 def: "Protein BMR1A_HUMAN with the residue 220 substituted with Phosphoserine" [UniProtKB:P36894] xref: UniProtKB:P36894 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005437 ! BMR1A_HUMAN [Term] id: CCO:B0010815 name: BMX_HUMAN-Phosphotyrosine566 def: "Protein BMX_HUMAN with the residue 566 substituted with Phosphotyrosine" [UniProtKB:P51813] comment: by autocatalysis; By similarity xref: UniProtKB:P51813 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005923 ! BMX_HUMAN [Term] id: CCO:B0010816 name: BNI3L_HUMAN-Phosphoserine62 def: "Protein BNI3L_HUMAN with the residue 62 substituted with Phosphoserine" [UniProtKB:O60238] comment: By similarity xref: UniProtKB:O60238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005714 ! BNI3L_HUMAN [Term] id: CCO:B0010817 name: BNI3L_HUMAN-Phosphoserine63 def: "Protein BNI3L_HUMAN with the residue 63 substituted with Phosphoserine" [UniProtKB:O60238] comment: By similarity xref: UniProtKB:O60238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005714 ! BNI3L_HUMAN [Term] id: CCO:B0010818 name: BNI3L_HUMAN-Phosphoserine117 def: "Protein BNI3L_HUMAN with the residue 117 substituted with Phosphoserine" [UniProtKB:O60238] comment: By similarity xref: UniProtKB:O60238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005714 ! BNI3L_HUMAN [Term] id: CCO:B0010819 name: BNI3L_HUMAN-Phosphoserine120 def: "Protein BNI3L_HUMAN with the residue 120 substituted with Phosphoserine" [UniProtKB:O60238] xref: UniProtKB:O60238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005714 ! BNI3L_HUMAN [Term] id: CCO:B0010823 name: BOREA_HUMAN-Phosphothreonine106 def: "Protein BOREA_HUMAN with the residue 106 substituted with Phosphothreonine" [UniProtKB:Q53HL2] xref: UniProtKB:Q53HL2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001839 ! BOREA_HUMAN [Term] id: CCO:B0010824 name: BOREA_HUMAN-Phosphoserine165 def: "Protein BOREA_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:Q53HL2] comment: Probable xref: UniProtKB:Q53HL2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000296 ! chromosome relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0001750 ! protein complex relationship: transformation_of CCO:B0001839 ! BOREA_HUMAN [Term] id: CCO:B0010825 name: BOREA_HUMAN-Phosphoserine219 def: "Protein BOREA_HUMAN with the residue 219 substituted with Phosphoserine" [UniProtKB:Q53HL2] xref: UniProtKB:Q53HL2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001839 ! BOREA_HUMAN [Term] id: CCO:B0010826 name: BPAEA_HUMAN-Phosphoserine1558 def: "Protein BPAEA_HUMAN with the residue 1558 substituted with Phosphoserine" [UniProtKB:O94833] xref: UniProtKB:O94833 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001443 ! BPAEA_HUMAN [Term] id: CCO:B0010827 name: BPAEA_HUMAN-Phosphoserine5111 def: "Protein BPAEA_HUMAN with the residue 5111 substituted with Phosphoserine" [UniProtKB:O94833] xref: UniProtKB:O94833 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001443 ! BPAEA_HUMAN [Term] id: CCO:B0010828 name: BPAEA_HUMAN-Phosphoserine5114 def: "Protein BPAEA_HUMAN with the residue 5114 substituted with Phosphoserine" [UniProtKB:O94833] xref: UniProtKB:O94833 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001443 ! BPAEA_HUMAN [Term] id: CCO:B0010829 name: BPAEA_HUMAN-Phosphoserine5163 def: "Protein BPAEA_HUMAN with the residue 5163 substituted with Phosphoserine" [UniProtKB:O94833] xref: UniProtKB:O94833 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001443 ! BPAEA_HUMAN [Term] id: CCO:B0010838 name: BRAP_HUMAN-Phosphoserine117 def: "Protein BRAP_HUMAN with the residue 117 substituted with Phosphoserine" [UniProtKB:Q7Z569] comment: By similarity xref: UniProtKB:Q7Z569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005471 ! BRAP_HUMAN [Term] id: CCO:B0010839 name: BRCA1_HUMAN-Phosphoserine840 def: "Protein BRCA1_HUMAN with the residue 840 substituted with Phosphoserine" [UniProtKB:P38398] comment: By similarity xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010840 name: BRCA1_HUMAN-Phosphoserine1143 def: "Protein BRCA1_HUMAN with the residue 1143 substituted with Phosphoserine" [UniProtKB:P38398] comment: by ATR; in vitro; xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010841 name: BRCA1_HUMAN-Phosphoserine1211 def: "Protein BRCA1_HUMAN with the residue 1211 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010842 name: BRCA1_HUMAN-Phosphoserine1212 def: "Protein BRCA1_HUMAN with the residue 1212 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010843 name: BRCA1_HUMAN-Phosphoserine1217 def: "Protein BRCA1_HUMAN with the residue 1217 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010844 name: BRCA1_HUMAN-Phosphoserine1218 def: "Protein BRCA1_HUMAN with the residue 1218 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010845 name: BRCA1_HUMAN-Phosphoserine1239 def: "Protein BRCA1_HUMAN with the residue 1239 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010846 name: BRCA1_HUMAN-Phosphoserine1245 def: "Protein BRCA1_HUMAN with the residue 1245 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010847 name: BRCA1_HUMAN-Phosphoserine1280 def: "Protein BRCA1_HUMAN with the residue 1280 substituted with Phosphoserine" [UniProtKB:P38398] comment: by ATR; in vitro; xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010848 name: BRCA1_HUMAN-Phosphoserine1330 def: "Protein BRCA1_HUMAN with the residue 1330 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000300 ! transcription coactivator activity relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0002987 ! tubulin binding relationship: has_function CCO:F0003205 ! transcription activator activity relationship: has_function CCO:F0004208 ! enzyme binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_function CCO:F0007990 ! androgen receptor binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000026 ! ubiquitin ligase complex relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000536 ! gamma-tubulin ring complex relationship: located_in CCO:C0001247 ! BRCA1-BARD1 complex relationship: located_in CCO:C0001750 ! protein complex relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010849 name: BRCA1_HUMAN-Phosphoserine1336 def: "Protein BRCA1_HUMAN with the residue 1336 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010850 name: BRCA1_HUMAN-Phosphoserine1342 def: "Protein BRCA1_HUMAN with the residue 1342 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010851 name: BRCA1_HUMAN-Phosphoserine1387 def: "Protein BRCA1_HUMAN with the residue 1387 substituted with Phosphoserine" [UniProtKB:P38398] comment: by ATM and ATR; xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010852 name: BRCA1_HUMAN-Phosphothreonine1394 def: "Protein BRCA1_HUMAN with the residue 1394 substituted with Phosphothreonine" [UniProtKB:P38398] comment: by ATR; in vitro; xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010853 name: BRCA1_HUMAN-Phosphoserine1423 def: "Protein BRCA1_HUMAN with the residue 1423 substituted with Phosphoserine" [UniProtKB:P38398] comment: by ATM and ATR; xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010854 name: BRCA1_HUMAN-Phosphoserine1457 def: "Protein BRCA1_HUMAN with the residue 1457 substituted with Phosphoserine" [UniProtKB:P38398] comment: by ATR; in vitro; xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010855 name: BRCA1_HUMAN-Phosphoserine1466 def: "Protein BRCA1_HUMAN with the residue 1466 substituted with Phosphoserine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010856 name: BRCA1_HUMAN-Phosphoserine1524 def: "Protein BRCA1_HUMAN with the residue 1524 substituted with Phosphoserine" [UniProtKB:P38398] comment: by ATM; xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010857 name: BRCA1_HUMAN-Phosphothreonine1700 def: "Protein BRCA1_HUMAN with the residue 1700 substituted with Phosphothreonine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010858 name: BRCA1_HUMAN-Phosphothreonine1720 def: "Protein BRCA1_HUMAN with the residue 1720 substituted with Phosphothreonine" [UniProtKB:P38398] xref: UniProtKB:P38398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:B0010859 name: BRCA2_HUMAN-Phosphoserine683 def: "Protein BRCA2_HUMAN with the residue 683 substituted with Phosphoserine" [UniProtKB:P51587] xref: UniProtKB:P51587 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000288 ! single-stranded DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003205 ! transcription activator activity relationship: has_function CCO:F0005782 ! gamma-tubulin binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000985 ! secretory granule relationship: located_in CCO:C0001583 ! BRCA2-MAGE-D1 complex relationship: located_in CCO:C0001750 ! protein complex relationship: transformation_of CCO:B0001649 ! BRCA2_HUMAN [Term] id: CCO:B0010860 name: BRCA2_HUMAN-Phosphoserine755 def: "Protein BRCA2_HUMAN with the residue 755 substituted with Phosphoserine" [UniProtKB:P51587] xref: UniProtKB:P51587 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001649 ! BRCA2_HUMAN [Term] id: CCO:B0010861 name: BRD4_HUMAN-Phosphoserine470 def: "Protein BRD4_HUMAN with the residue 470 substituted with Phosphoserine" [UniProtKB:O60885] xref: UniProtKB:O60885 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006311 ! BRD4_HUMAN [Term] id: CCO:B0010862 name: BRD4_HUMAN-Phosphoserine601 def: "Protein BRD4_HUMAN with the residue 601 substituted with Phosphoserine" [UniProtKB:O60885] xref: UniProtKB:O60885 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006311 ! BRD4_HUMAN [Term] id: CCO:B0010863 name: BRD4_HUMAN-Phosphoserine1045 def: "Protein BRD4_HUMAN with the residue 1045 substituted with Phosphoserine" [UniProtKB:O60885] xref: UniProtKB:O60885 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006311 ! BRD4_HUMAN [Term] id: CCO:B0010864 name: BRD4_HUMAN-Phosphoserine1117 def: "Protein BRD4_HUMAN with the residue 1117 substituted with Phosphoserine" [UniProtKB:O60885] xref: UniProtKB:O60885 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006311 ! BRD4_HUMAN [Term] id: CCO:B0010865 name: BRD7_HUMAN-Phosphoserine279 def: "Protein BRD7_HUMAN with the residue 279 substituted with Phosphoserine" [UniProtKB:Q9NPI1] xref: UniProtKB:Q9NPI1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005400 ! BRD7_HUMAN [Term] id: CCO:B0010866 name: BRSK1_HUMAN-Phosphothreonine205 def: "Protein BRSK1_HUMAN with the residue 205 substituted with Phosphothreonine" [UniProtKB:Q8TDC3] xref: UniProtKB:Q8TDC3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001992 ! BRSK1_HUMAN [Term] id: CCO:B0010867 name: BRSK1_HUMAN-Phosphoserine209 def: "Protein BRSK1_HUMAN with the residue 209 substituted with Phosphoserine" [UniProtKB:Q8TDC3] comment: By similarity xref: UniProtKB:Q8TDC3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001992 ! BRSK1_HUMAN [Term] id: CCO:B0010869 name: BUB1_HUMAN-Phosphoserine314 def: "Protein BUB1_HUMAN with the residue 314 substituted with Phosphoserine" [UniProtKB:O43683] xref: UniProtKB:O43683 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001395 ! BUB1_HUMAN [Term] id: CCO:B0010870 name: BUB3_HUMAN-Phosphoserine211 def: "Protein BUB3_HUMAN with the residue 211 substituted with Phosphoserine" [UniProtKB:O43684] xref: UniProtKB:O43684 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001396 ! BUB3_HUMAN [Term] id: CCO:B0010871 name: CABL1_HUMAN-Phosphoserine168 def: "Protein CABL1_HUMAN with the residue 168 substituted with Phosphoserine" [UniProtKB:Q8TDN4] xref: UniProtKB:Q8TDN4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001994 ! CABL1_HUMAN [Term] id: CCO:B0010872 name: CABL1_HUMAN-Phosphoserine313 def: "Protein CABL1_HUMAN with the residue 313 substituted with Phosphoserine" [UniProtKB:Q8TDN4] comment: by CDK2 and CDK3; By similarity xref: UniProtKB:Q8TDN4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001994 ! CABL1_HUMAN [Term] id: CCO:B0010873 name: CAC1A_HUMAN-Phosphoserine750 def: "Protein CAC1A_HUMAN with the residue 750 substituted with Phosphoserine" [UniProtKB:O00555] comment: By similarity xref: UniProtKB:O00555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006044 ! CAC1A_HUMAN [Term] id: CCO:B0010874 name: CAC1A_HUMAN-Phosphoserine1822 def: "Protein CAC1A_HUMAN with the residue 1822 substituted with Phosphoserine" [UniProtKB:O00555] comment: by PKA; Potential xref: UniProtKB:O00555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006044 ! CAC1A_HUMAN [Term] id: CCO:B0010875 name: CAC1A_HUMAN-Phosphoserine2030 def: "Protein CAC1A_HUMAN with the residue 2030 substituted with Phosphoserine" [UniProtKB:O00555] comment: By similarity xref: UniProtKB:O00555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006044 ! CAC1A_HUMAN [Term] id: CCO:B0010876 name: CAC1A_HUMAN-Phosphotyrosine2076 def: "Protein CAC1A_HUMAN with the residue 2076 substituted with Phosphotyrosine" [UniProtKB:O00555] comment: By similarity xref: UniProtKB:O00555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006044 ! CAC1A_HUMAN [Term] id: CCO:B0010877 name: CAC1A_HUMAN-Phosphoserine2269 def: "Protein CAC1A_HUMAN with the residue 2269 substituted with Phosphoserine" [UniProtKB:O00555] comment: By similarity xref: UniProtKB:O00555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006044 ! CAC1A_HUMAN [Term] id: CCO:B0010878 name: CAC1A_HUMAN-Phosphoserine2378 def: "Protein CAC1A_HUMAN with the residue 2378 substituted with Phosphoserine" [UniProtKB:O00555] comment: By similarity xref: UniProtKB:O00555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006044 ! CAC1A_HUMAN [Term] id: CCO:B0010891 name: CAF1A_HUMAN-Phosphoserine47 def: "Protein CAF1A_HUMAN with the residue 47 substituted with Phosphoserine" [UniProtKB:Q13111] xref: UniProtKB:Q13111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:B0010892 name: CAF1A_HUMAN-Phosphoserine123 def: "Protein CAF1A_HUMAN with the residue 123 substituted with Phosphoserine" [UniProtKB:Q13111] xref: UniProtKB:Q13111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:B0010893 name: CAF1A_HUMAN-Phosphoserine181 def: "Protein CAF1A_HUMAN with the residue 181 substituted with Phosphoserine" [UniProtKB:Q13111] xref: UniProtKB:Q13111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:B0010894 name: CAF1A_HUMAN-Phosphoserine185 def: "Protein CAF1A_HUMAN with the residue 185 substituted with Phosphoserine" [UniProtKB:Q13111] xref: UniProtKB:Q13111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:B0010895 name: CAF1A_HUMAN-Phosphoserine188 def: "Protein CAF1A_HUMAN with the residue 188 substituted with Phosphoserine" [UniProtKB:Q13111] xref: UniProtKB:Q13111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:B0010896 name: CAF1A_HUMAN-Phosphoserine237 def: "Protein CAF1A_HUMAN with the residue 237 substituted with Phosphoserine" [UniProtKB:Q13111] xref: UniProtKB:Q13111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:B0010897 name: CAF1A_HUMAN-Phosphothreonine241 def: "Protein CAF1A_HUMAN with the residue 241 substituted with Phosphothreonine" [UniProtKB:Q13111] xref: UniProtKB:Q13111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:B0010898 name: CAF1A_HUMAN-Phosphoserine754 def: "Protein CAF1A_HUMAN with the residue 754 substituted with Phosphoserine" [UniProtKB:Q13111] xref: UniProtKB:Q13111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:B0010899 name: CAF1A_HUMAN-Phosphoserine933 def: "Protein CAF1A_HUMAN with the residue 933 substituted with Phosphoserine" [UniProtKB:Q13111] xref: UniProtKB:Q13111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:B0010900 name: CAF1B_HUMAN-Phosphoserine429 def: "Protein CAF1B_HUMAN with the residue 429 substituted with Phosphoserine" [UniProtKB:Q13112] xref: UniProtKB:Q13112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001743 ! CAF1B_HUMAN [Term] id: CCO:B0010901 name: CAF1B_HUMAN-Phosphoserine458 def: "Protein CAF1B_HUMAN with the residue 458 substituted with Phosphoserine" [UniProtKB:Q13112] xref: UniProtKB:Q13112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001743 ! CAF1B_HUMAN [Term] id: CCO:B0010902 name: CAF1B_HUMAN-Phosphothreonine485 def: "Protein CAF1B_HUMAN with the residue 485 substituted with Phosphothreonine" [UniProtKB:Q13112] xref: UniProtKB:Q13112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001743 ! CAF1B_HUMAN [Term] id: CCO:B0010903 name: CAF1B_HUMAN-Phosphothreonine495 def: "Protein CAF1B_HUMAN with the residue 495 substituted with Phosphothreonine" [UniProtKB:Q13112] comment: Potential xref: UniProtKB:Q13112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000278 ! chromatin binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0005669 ! histone binding relationship: has_function CCO:F0008055 ! unfolded protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000281 ! chromatin assembly complex relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001743 ! CAF1B_HUMAN [Term] id: CCO:B0010904 name: CAF1B_HUMAN-Phosphothreonine503 def: "Protein CAF1B_HUMAN with the residue 503 substituted with Phosphothreonine" [UniProtKB:Q13112] comment: Potential xref: UniProtKB:Q13112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001743 ! CAF1B_HUMAN [Term] id: CCO:B0010905 name: CAF1B_HUMAN-Phosphothreonine509 def: "Protein CAF1B_HUMAN with the residue 509 substituted with Phosphothreonine" [UniProtKB:Q13112] comment: Potential xref: UniProtKB:Q13112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001743 ! CAF1B_HUMAN [Term] id: CCO:B0010906 name: CAF1B_HUMAN-Phosphothreonine521 def: "Protein CAF1B_HUMAN with the residue 521 substituted with Phosphothreonine" [UniProtKB:Q13112] comment: Potential xref: UniProtKB:Q13112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001743 ! CAF1B_HUMAN [Term] id: CCO:B0010907 name: CAF1B_HUMAN-Phosphothreonine531 def: "Protein CAF1B_HUMAN with the residue 531 substituted with Phosphothreonine" [UniProtKB:Q13112] comment: Potential xref: UniProtKB:Q13112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001743 ! CAF1B_HUMAN [Term] id: CCO:B0010908 name: CAF1B_HUMAN-Phosphoserine538 def: "Protein CAF1B_HUMAN with the residue 538 substituted with Phosphoserine" [UniProtKB:Q13112] xref: UniProtKB:Q13112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001743 ! CAF1B_HUMAN [Term] id: CCO:B0010909 name: CALM_HUMAN-N-acetylalanine2 def: "Protein CALM_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P62158] xref: UniProtKB:P62158 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001690 ! CALM_HUMAN [Term] id: CCO:B0010910 name: CALM_HUMAN-Phosphothreonine45 def: "Protein CALM_HUMAN with the residue 45 substituted with Phosphothreonine" [UniProtKB:P62158] comment: by CaMK4; By similarity xref: UniProtKB:P62158 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001690 ! CALM_HUMAN [Term] id: CCO:B0010911 name: CALM_HUMAN-Phosphotyrosine100 def: "Protein CALM_HUMAN with the residue 100 substituted with Phosphotyrosine" [UniProtKB:P62158] xref: UniProtKB:P62158 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001690 ! CALM_HUMAN [Term] id: CCO:B0010912 name: CALM_HUMAN-N6,N6,N6-trimethyllysine116 def: "Protein CALM_HUMAN with the residue 116 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P62158] xref: UniProtKB:P62158 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001690 ! CALM_HUMAN [Term] id: CCO:B0010915 name: CASC5_HUMAN-Phosphoserine32 def: "Protein CASC5_HUMAN with the residue 32 substituted with Phosphoserine" [UniProtKB:Q8NG31] xref: UniProtKB:Q8NG31 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:B0010916 name: CASC5_HUMAN-Phosphoserine60 def: "Protein CASC5_HUMAN with the residue 60 substituted with Phosphoserine" [UniProtKB:Q8NG31] xref: UniProtKB:Q8NG31 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:B0010917 name: CASC5_HUMAN-Phosphoserine765 def: "Protein CASC5_HUMAN with the residue 765 substituted with Phosphoserine" [UniProtKB:Q8NG31] xref: UniProtKB:Q8NG31 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:B0010918 name: CASC5_HUMAN-Phosphoserine767 def: "Protein CASC5_HUMAN with the residue 767 substituted with Phosphoserine" [UniProtKB:Q8NG31] xref: UniProtKB:Q8NG31 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:B0010919 name: CASC5_HUMAN-Phosphoserine956 def: "Protein CASC5_HUMAN with the residue 956 substituted with Phosphoserine" [UniProtKB:Q8NG31] xref: UniProtKB:Q8NG31 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:B0010920 name: CASC5_HUMAN-Phosphoserine1039 def: "Protein CASC5_HUMAN with the residue 1039 substituted with Phosphoserine" [UniProtKB:Q8NG31] xref: UniProtKB:Q8NG31 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:B0010921 name: CASC5_HUMAN-Phosphothreonine1042 def: "Protein CASC5_HUMAN with the residue 1042 substituted with Phosphothreonine" [UniProtKB:Q8NG31] xref: UniProtKB:Q8NG31 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:B0010922 name: CASC5_HUMAN-Phosphoserine1076 def: "Protein CASC5_HUMAN with the residue 1076 substituted with Phosphoserine" [UniProtKB:Q8NG31] xref: UniProtKB:Q8NG31 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:B0010923 name: CASC5_HUMAN-Phosphoserine1773 def: "Protein CASC5_HUMAN with the residue 1773 substituted with Phosphoserine" [UniProtKB:Q8NG31] xref: UniProtKB:Q8NG31 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:B0010924 name: CASL_HUMAN-Phosphotyrosine12 def: "Protein CASL_HUMAN with the residue 12 substituted with Phosphotyrosine" [UniProtKB:Q14511] xref: UniProtKB:Q14511 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001782 ! CASL_HUMAN [Term] id: CCO:B0010925 name: CASL_HUMAN-Phosphotyrosine92 def: "Protein CASL_HUMAN with the residue 92 substituted with Phosphotyrosine" [UniProtKB:Q14511] comment: By similarity xref: UniProtKB:Q14511 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001782 ! CASL_HUMAN [Term] id: CCO:B0010926 name: CASL_HUMAN-Phosphotyrosine166 def: "Protein CASL_HUMAN with the residue 166 substituted with Phosphotyrosine" [UniProtKB:Q14511] xref: UniProtKB:Q14511 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000375 ! Golgi apparatus relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000421 ! cytoskeleton relationship: located_in CCO:C0000936 ! cell junction relationship: located_in CCO:C0001706 ! cell projection relationship: transformation_of CCO:B0001782 ! CASL_HUMAN [Term] id: CCO:B0010927 name: CASL_HUMAN-Phosphotyrosine177 def: "Protein CASL_HUMAN with the residue 177 substituted with Phosphotyrosine" [UniProtKB:Q14511] comment: By similarity xref: UniProtKB:Q14511 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001782 ! CASL_HUMAN [Term] id: CCO:B0010928 name: CASL_HUMAN-Phosphotyrosine189 def: "Protein CASL_HUMAN with the residue 189 substituted with Phosphotyrosine" [UniProtKB:Q14511] comment: By similarity xref: UniProtKB:Q14511 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001782 ! CASL_HUMAN [Term] id: CCO:B0010929 name: CAV1_HUMAN-N-acetylserine2 def: "Protein CAV1_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:Q03135] xref: UniProtKB:Q03135 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005456 ! CAV1_HUMAN [Term] id: CCO:B0010930 name: CAV1_HUMAN-Phosphotyrosine6 def: "Protein CAV1_HUMAN with the residue 6 substituted with Phosphotyrosine" [UniProtKB:Q03135] xref: UniProtKB:Q03135 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005456 ! CAV1_HUMAN [Term] id: CCO:B0010931 name: CAV1_HUMAN-Phosphotyrosine14 def: "Protein CAV1_HUMAN with the residue 14 substituted with Phosphotyrosine" [UniProtKB:Q03135] xref: UniProtKB:Q03135 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005456 ! CAV1_HUMAN [Term] id: CCO:B0010932 name: CAV1_HUMAN-Phosphotyrosine25 def: "Protein CAV1_HUMAN with the residue 25 substituted with Phosphotyrosine" [UniProtKB:Q03135] xref: UniProtKB:Q03135 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005456 ! CAV1_HUMAN [Term] id: CCO:B0010933 name: CAV1_HUMAN-Phosphoserine37 def: "Protein CAV1_HUMAN with the residue 37 substituted with Phosphoserine" [UniProtKB:Q03135] xref: UniProtKB:Q03135 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005456 ! CAV1_HUMAN [Term] id: CCO:B0010934 name: CAV2_HUMAN-Phosphotyrosine19 def: "Protein CAV2_HUMAN with the residue 19 substituted with Phosphotyrosine" [UniProtKB:P51636] xref: UniProtKB:P51636 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005462 ! CAV2_HUMAN [Term] id: CCO:B0010935 name: CAV2_HUMAN-Phosphoserine20 def: "Protein CAV2_HUMAN with the residue 20 substituted with Phosphoserine" [UniProtKB:P51636] xref: UniProtKB:P51636 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005462 ! CAV2_HUMAN [Term] id: CCO:B0010936 name: CAV2_HUMAN-Phosphoserine23 def: "Protein CAV2_HUMAN with the residue 23 substituted with Phosphoserine" [UniProtKB:P51636] xref: UniProtKB:P51636 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005462 ! CAV2_HUMAN [Term] id: CCO:B0010937 name: CAV2_HUMAN-Phosphotyrosine27 def: "Protein CAV2_HUMAN with the residue 27 substituted with Phosphotyrosine" [UniProtKB:P51636] xref: UniProtKB:P51636 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005462 ! CAV2_HUMAN [Term] id: CCO:B0010938 name: CAV2_HUMAN-Phosphoserine36 def: "Protein CAV2_HUMAN with the residue 36 substituted with Phosphoserine" [UniProtKB:P51636] xref: UniProtKB:P51636 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005462 ! CAV2_HUMAN [Term] id: CCO:B0010939 name: CBLB_HUMAN-Phosphoserine480 def: "Protein CBLB_HUMAN with the residue 480 substituted with Phosphoserine" [UniProtKB:Q13191] xref: UniProtKB:Q13191 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005819 ! CBLB_HUMAN [Term] id: CCO:B0010940 name: CBLB_HUMAN-Phosphoserine484 def: "Protein CBLB_HUMAN with the residue 484 substituted with Phosphoserine" [UniProtKB:Q13191] xref: UniProtKB:Q13191 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005819 ! CBLB_HUMAN [Term] id: CCO:B0010941 name: CBLB_HUMAN-Phosphotyrosine665 def: "Protein CBLB_HUMAN with the residue 665 substituted with Phosphotyrosine" [UniProtKB:Q13191] xref: UniProtKB:Q13191 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005819 ! CBLB_HUMAN [Term] id: CCO:B0010942 name: CBLB_HUMAN-Phosphotyrosine709 def: "Protein CBLB_HUMAN with the residue 709 substituted with Phosphotyrosine" [UniProtKB:Q13191] xref: UniProtKB:Q13191 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005819 ! CBLB_HUMAN [Term] id: CCO:B0010943 name: CBLB_HUMAN-Phosphotyrosine889 def: "Protein CBLB_HUMAN with the residue 889 substituted with Phosphotyrosine" [UniProtKB:Q13191] comment: By similarity xref: UniProtKB:Q13191 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005819 ! CBLB_HUMAN [Term] id: CCO:B0010944 name: CBL_HUMAN-Phosphotyrosine371 def: "Protein CBL_HUMAN with the residue 371 substituted with Phosphotyrosine" [UniProtKB:P22681] comment: by INSR; xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0010945 name: CBL_HUMAN-Phosphotyrosine552 def: "Protein CBL_HUMAN with the residue 552 substituted with Phosphotyrosine" [UniProtKB:P22681] xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0010946 name: CBL_HUMAN-Phosphoserine667 def: "Protein CBL_HUMAN with the residue 667 substituted with Phosphoserine" [UniProtKB:P22681] xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0010947 name: CBL_HUMAN-Phosphoserine669 def: "Protein CBL_HUMAN with the residue 669 substituted with Phosphoserine" [UniProtKB:P22681] xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0010948 name: CBL_HUMAN-Phosphotyrosine674 def: "Protein CBL_HUMAN with the residue 674 substituted with Phosphotyrosine" [UniProtKB:P22681] xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0010949 name: CBL_HUMAN-Phosphoserine675 def: "Protein CBL_HUMAN with the residue 675 substituted with Phosphoserine" [UniProtKB:P22681] xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0010950 name: CBL_HUMAN-Phosphotyrosine700 def: "Protein CBL_HUMAN with the residue 700 substituted with Phosphotyrosine" [UniProtKB:P22681] xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0010951 name: CBL_HUMAN-Phosphotyrosine774 def: "Protein CBL_HUMAN with the residue 774 substituted with Phosphotyrosine" [UniProtKB:P22681] xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0010952 name: CBL_HUMAN-Phosphoserine900 def: "Protein CBL_HUMAN with the residue 900 substituted with Phosphoserine" [UniProtKB:P22681] xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0010953 name: CBP_HUMAN-Phosphoserine124 def: "Protein CBP_HUMAN with the residue 124 substituted with Phosphoserine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010954 name: CBP_HUMAN-Omega-N-methylated arginine601 def: "Protein CBP_HUMAN with the residue 601 substituted with Omega-N-methylated arginine" [UniProtKB:Q92793] comment: By similarity xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010955 name: CBP_HUMAN-Omega-N-methylated arginine625 def: "Protein CBP_HUMAN with the residue 625 substituted with Omega-N-methylated arginine" [UniProtKB:Q92793] comment: By similarity xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010956 name: CBP_HUMAN-Phosphothreonine1001 def: "Protein CBP_HUMAN with the residue 1001 substituted with Phosphothreonine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010957 name: CBP_HUMAN-Phosphoserine1030 def: "Protein CBP_HUMAN with the residue 1030 substituted with Phosphoserine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010958 name: CBP_HUMAN-Phosphoserine1072 def: "Protein CBP_HUMAN with the residue 1072 substituted with Phosphoserine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010959 name: CBP_HUMAN-N6-acetyllysine1588 def: "Protein CBP_HUMAN with the residue 1588 substituted with N6-acetyllysine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010960 name: CBP_HUMAN-N6-acetyllysine1591 def: "Protein CBP_HUMAN with the residue 1591 substituted with N6-acetyllysine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010961 name: CBP_HUMAN-N6-acetyllysine1592 def: "Protein CBP_HUMAN with the residue 1592 substituted with N6-acetyllysine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010962 name: CBP_HUMAN-N6-acetyllysine1595 def: "Protein CBP_HUMAN with the residue 1595 substituted with N6-acetyllysine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010963 name: CBP_HUMAN-N6-acetyllysine1597 def: "Protein CBP_HUMAN with the residue 1597 substituted with N6-acetyllysine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010964 name: CBP_HUMAN-Phosphoserine1755 def: "Protein CBP_HUMAN with the residue 1755 substituted with Phosphoserine" [UniProtKB:Q92793] xref: UniProtKB:Q92793 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:B0010965 name: CBX1_HUMAN-Phosphoserine89 def: "Protein CBX1_HUMAN with the residue 89 substituted with Phosphoserine" [UniProtKB:P83916] xref: UniProtKB:P83916 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006126 ! CBX1_HUMAN [Term] id: CCO:B0010966 name: CBX1_HUMAN-Phosphoserine175 def: "Protein CBX1_HUMAN with the residue 175 substituted with Phosphoserine" [UniProtKB:P83916] xref: UniProtKB:P83916 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006126 ! CBX1_HUMAN [Term] id: CCO:B0010967 name: CBX5_HUMAN-Phosphothreonine8 def: "Protein CBX5_HUMAN with the residue 8 substituted with Phosphothreonine" [UniProtKB:P45973] xref: UniProtKB:P45973 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:B0010968 name: CBX5_HUMAN-Phosphoserine11 def: "Protein CBX5_HUMAN with the residue 11 substituted with Phosphoserine" [UniProtKB:P45973] xref: UniProtKB:P45973 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:B0010969 name: CBX5_HUMAN-Phosphoserine12 def: "Protein CBX5_HUMAN with the residue 12 substituted with Phosphoserine" [UniProtKB:P45973] xref: UniProtKB:P45973 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:B0010970 name: CBX5_HUMAN-Phosphoserine13 def: "Protein CBX5_HUMAN with the residue 13 substituted with Phosphoserine" [UniProtKB:P45973] xref: UniProtKB:P45973 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:B0010971 name: CBX5_HUMAN-Phosphoserine14 def: "Protein CBX5_HUMAN with the residue 14 substituted with Phosphoserine" [UniProtKB:P45973] xref: UniProtKB:P45973 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:B0010972 name: CBX5_HUMAN-Phosphoserine92 def: "Protein CBX5_HUMAN with the residue 92 substituted with Phosphoserine" [UniProtKB:P45973] xref: UniProtKB:P45973 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:B0010973 name: CBX5_HUMAN-Phosphoserine110 def: "Protein CBX5_HUMAN with the residue 110 substituted with Phosphoserine" [UniProtKB:P45973] xref: UniProtKB:P45973 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:B0010974 name: CCAR1_HUMAN-Phosphoserine214 def: "Protein CCAR1_HUMAN with the residue 214 substituted with Phosphoserine" [UniProtKB:Q8IX12] xref: UniProtKB:Q8IX12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001950 ! CCAR1_HUMAN [Term] id: CCO:B0010975 name: CCAR1_HUMAN-Phosphoserine329 def: "Protein CCAR1_HUMAN with the residue 329 substituted with Phosphoserine" [UniProtKB:Q8IX12] xref: UniProtKB:Q8IX12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001950 ! CCAR1_HUMAN [Term] id: CCO:B0010976 name: CCAR1_HUMAN-Phosphoserine333 def: "Protein CCAR1_HUMAN with the residue 333 substituted with Phosphoserine" [UniProtKB:Q8IX12] xref: UniProtKB:Q8IX12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001950 ! CCAR1_HUMAN [Term] id: CCO:B0010977 name: CCAR1_HUMAN-Phosphoserine339 def: "Protein CCAR1_HUMAN with the residue 339 substituted with Phosphoserine" [UniProtKB:Q8IX12] xref: UniProtKB:Q8IX12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001950 ! CCAR1_HUMAN [Term] id: CCO:B0010978 name: CCAR1_HUMAN-Phosphoserine343 def: "Protein CCAR1_HUMAN with the residue 343 substituted with Phosphoserine" [UniProtKB:Q8IX12] xref: UniProtKB:Q8IX12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001950 ! CCAR1_HUMAN [Term] id: CCO:B0010979 name: CCAR1_HUMAN-Phosphoserine1149 def: "Protein CCAR1_HUMAN with the residue 1149 substituted with Phosphoserine" [UniProtKB:Q8IX12] xref: UniProtKB:Q8IX12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001950 ! CCAR1_HUMAN [Term] id: CCO:B0010980 name: CCD16_HUMAN-Phosphoserine89 def: "Protein CCD16_HUMAN with the residue 89 substituted with Phosphoserine" [UniProtKB:Q96NB3] xref: UniProtKB:Q96NB3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002051 ! CCD16_HUMAN [Term] id: CCO:B0010981 name: CCD16_HUMAN-Phosphoserine351 def: "Protein CCD16_HUMAN with the residue 351 substituted with Phosphoserine" [UniProtKB:Q96NB3] xref: UniProtKB:Q96NB3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002051 ! CCD16_HUMAN [Term] id: CCO:B0010982 name: CCD16_HUMAN-Phosphoserine362 def: "Protein CCD16_HUMAN with the residue 362 substituted with Phosphoserine" [UniProtKB:Q96NB3] xref: UniProtKB:Q96NB3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002051 ! CCD16_HUMAN [Term] id: CCO:B0010983 name: CCD99_HUMAN-Phosphotyrosine279 def: "Protein CCD99_HUMAN with the residue 279 substituted with Phosphotyrosine" [UniProtKB:Q96EA4] comment: By similarity xref: UniProtKB:Q96EA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006191 ! CCD99_HUMAN [Term] id: CCO:B0010984 name: CCD99_HUMAN-Phosphothreonine487 def: "Protein CCD99_HUMAN with the residue 487 substituted with Phosphothreonine" [UniProtKB:Q96EA4] xref: UniProtKB:Q96EA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006191 ! CCD99_HUMAN [Term] id: CCO:B0010985 name: CCD99_HUMAN-Phosphoserine515 def: "Protein CCD99_HUMAN with the residue 515 substituted with Phosphoserine" [UniProtKB:Q96EA4] xref: UniProtKB:Q96EA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006191 ! CCD99_HUMAN [Term] id: CCO:B0010986 name: CCD99_HUMAN-Phosphoserine555 def: "Protein CCD99_HUMAN with the residue 555 substituted with Phosphoserine" [UniProtKB:Q96EA4] xref: UniProtKB:Q96EA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006191 ! CCD99_HUMAN [Term] id: CCO:B0010992 name: CCNE1_HUMAN-Phosphoserine59 def: "Protein CCNE1_HUMAN with the residue 59 substituted with Phosphoserine" [UniProtKB:P24864] xref: UniProtKB:P24864 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001554 ! CCNE1_HUMAN [Term] id: CCO:B0010993 name: CCNE1_HUMAN-Phosphothreonine77 def: "Protein CCNE1_HUMAN with the residue 77 substituted with Phosphothreonine" [UniProtKB:P24864] xref: UniProtKB:P24864 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001554 ! CCNE1_HUMAN [Term] id: CCO:B0010994 name: CCNE1_HUMAN-Phosphoserine387 def: "Protein CCNE1_HUMAN with the residue 387 substituted with Phosphoserine" [UniProtKB:P24864] xref: UniProtKB:P24864 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001554 ! CCNE1_HUMAN [Term] id: CCO:B0010995 name: CCNE1_HUMAN-Phosphothreonine395 def: "Protein CCNE1_HUMAN with the residue 395 substituted with Phosphothreonine" [UniProtKB:P24864] comment: by GSK3; xref: UniProtKB:P24864 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001554 ! CCNE1_HUMAN [Term] id: CCO:B0010996 name: CCNE1_HUMAN-Phosphoserine399 def: "Protein CCNE1_HUMAN with the residue 399 substituted with Phosphoserine" [UniProtKB:P24864] comment: by CDK2; xref: UniProtKB:P24864 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001554 ! CCNE1_HUMAN [Term] id: CCO:B0010997 name: CCNE2_HUMAN-Phosphothreonine392 def: "Protein CCNE2_HUMAN with the residue 392 substituted with Phosphothreonine" [UniProtKB:O96020] comment: Probable xref: UniProtKB:O96020 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0001460 ! CCNE2_HUMAN [Term] id: CCO:B0010998 name: CCNH_HUMAN-Phosphoserine5 def: "Protein CCNH_HUMAN with the residue 5 substituted with Phosphoserine" [UniProtKB:P51946] comment: by CDK8; xref: UniProtKB:P51946 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000901 ! cyclin-dependent protein kinase activating kinase holoenzyme complex relationship: transformation_of CCO:B0001652 ! CCNH_HUMAN [Term] id: CCO:B0010999 name: CCNH_HUMAN-Phosphoserine304 def: "Protein CCNH_HUMAN with the residue 304 substituted with Phosphoserine" [UniProtKB:P51946] comment: by CDK8; xref: UniProtKB:P51946 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001652 ! CCNH_HUMAN [Term] id: CCO:B0011000 name: CCNH_HUMAN-Phosphothreonine315 def: "Protein CCNH_HUMAN with the residue 315 substituted with Phosphothreonine" [UniProtKB:P51946] xref: UniProtKB:P51946 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001652 ! CCNH_HUMAN [Term] id: CCO:B0011001 name: CCNK_HUMAN-Phosphoserine324 def: "Protein CCNK_HUMAN with the residue 324 substituted with Phosphoserine" [UniProtKB:O75909] xref: UniProtKB:O75909 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001439 ! CCNK_HUMAN [Term] id: CCO:B0011002 name: CCNK_HUMAN-Phosphoserine329 def: "Protein CCNK_HUMAN with the residue 329 substituted with Phosphoserine" [UniProtKB:O75909] xref: UniProtKB:O75909 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001439 ! CCNK_HUMAN [Term] id: CCO:B0011003 name: CCNK_HUMAN-Phosphoserine340 def: "Protein CCNK_HUMAN with the residue 340 substituted with Phosphoserine" [UniProtKB:O75909] xref: UniProtKB:O75909 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001439 ! CCNK_HUMAN [Term] id: CCO:B0011006 name: CCNT1_HUMAN-N6-acetyllysine492 def: "Protein CCNT1_HUMAN with the residue 492 substituted with N6-acetyllysine" [UniProtKB:O60563] xref: UniProtKB:O60563 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001410 ! CCNT1_HUMAN [Term] id: CCO:B0011007 name: CCNT2_HUMAN-Phosphoserine480 def: "Protein CCNT2_HUMAN with the residue 480 substituted with Phosphoserine" [UniProtKB:O60583] xref: UniProtKB:O60583 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001412 ! CCNT2_HUMAN [Term] id: CCO:B0011011 name: CCPG1_HUMAN-Phosphothreonine99 def: "Protein CCPG1_HUMAN with the residue 99 substituted with Phosphothreonine" [UniProtKB:Q9ULG6] xref: UniProtKB:Q9ULG6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002225 ! CCPG1_HUMAN [Term] id: CCO:B0011012 name: CCPG1_HUMAN-Phosphoserine101 def: "Protein CCPG1_HUMAN with the residue 101 substituted with Phosphoserine" [UniProtKB:Q9ULG6] xref: UniProtKB:Q9ULG6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002225 ! CCPG1_HUMAN [Term] id: CCO:B0011013 name: CCPG1_HUMAN-Phosphoserine104 def: "Protein CCPG1_HUMAN with the residue 104 substituted with Phosphoserine" [UniProtKB:Q9ULG6] xref: UniProtKB:Q9ULG6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002225 ! CCPG1_HUMAN [Term] id: CCO:B0011014 name: CD28_HUMAN-Phosphotyrosine191 def: "Protein CD28_HUMAN with the residue 191 substituted with Phosphotyrosine" [UniProtKB:P10747] xref: UniProtKB:P10747 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001508 ! CD28_HUMAN [Term] id: CCO:B0011015 name: CD28_HUMAN-Phosphotyrosine209 def: "Protein CD28_HUMAN with the residue 209 substituted with Phosphotyrosine" [UniProtKB:P10747] xref: UniProtKB:P10747 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001508 ! CD28_HUMAN [Term] id: CCO:B0011016 name: CD2AP_HUMAN-Phosphotyrosine88 def: "Protein CD2AP_HUMAN with the residue 88 substituted with Phosphotyrosine" [UniProtKB:Q9Y5K6] xref: UniProtKB:Q9Y5K6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002257 ! CD2AP_HUMAN [Term] id: CCO:B0011017 name: CD2AP_HUMAN-Phosphoserine510 def: "Protein CD2AP_HUMAN with the residue 510 substituted with Phosphoserine" [UniProtKB:Q9Y5K6] xref: UniProtKB:Q9Y5K6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002257 ! CD2AP_HUMAN [Term] id: CCO:B0011018 name: CD2L1_HUMAN-Phosphoserine283 def: "Protein CD2L1_HUMAN with the residue 283 substituted with Phosphoserine" [UniProtKB:P21127] xref: UniProtKB:P21127 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001540 ! CD2L1_HUMAN [Term] id: CCO:B0011019 name: CD2L1_HUMAN-Phosphothreonine448 def: "Protein CD2L1_HUMAN with the residue 448 substituted with Phosphothreonine" [UniProtKB:P21127] comment: By similarity xref: UniProtKB:P21127 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001540 ! CD2L1_HUMAN [Term] id: CCO:B0011020 name: CD2L1_HUMAN-Phosphotyrosine449 def: "Protein CD2L1_HUMAN with the residue 449 substituted with Phosphotyrosine" [UniProtKB:P21127] comment: By similarity xref: UniProtKB:P21127 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001540 ! CD2L1_HUMAN [Term] id: CCO:B0011021 name: CD2L1_HUMAN-Phosphoserine589 def: "Protein CD2L1_HUMAN with the residue 589 substituted with Phosphoserine" [UniProtKB:P21127] xref: UniProtKB:P21127 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001540 ! CD2L1_HUMAN [Term] id: CCO:B0011022 name: CD2L1_HUMAN-Phosphothreonine595 def: "Protein CD2L1_HUMAN with the residue 595 substituted with Phosphothreonine" [UniProtKB:P21127] xref: UniProtKB:P21127 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001540 ! CD2L1_HUMAN [Term] id: CCO:B0011023 name: CD2L1_HUMAN-Phosphothreonine751 def: "Protein CD2L1_HUMAN with the residue 751 substituted with Phosphothreonine" [UniProtKB:P21127] comment: By similarity xref: UniProtKB:P21127 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001540 ! CD2L1_HUMAN [Term] id: CCO:B0011024 name: CD2L1_HUMAN-Phosphoserine752 def: "Protein CD2L1_HUMAN with the residue 752 substituted with Phosphoserine" [UniProtKB:P21127] comment: By similarity xref: UniProtKB:P21127 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001540 ! CD2L1_HUMAN [Term] id: CCO:B0011025 name: CD2L2_HUMAN-Phosphoserine222 def: "Protein CD2L2_HUMAN with the residue 222 substituted with Phosphoserine" [UniProtKB:Q9UQ88] xref: UniProtKB:Q9UQ88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002241 ! CD2L2_HUMAN [Term] id: CCO:B0011026 name: CD2L2_HUMAN-Phosphoserine271 def: "Protein CD2L2_HUMAN with the residue 271 substituted with Phosphoserine" [UniProtKB:Q9UQ88] xref: UniProtKB:Q9UQ88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002241 ! CD2L2_HUMAN [Term] id: CCO:B0011027 name: CD2L2_HUMAN-Phosphothreonine433 def: "Protein CD2L2_HUMAN with the residue 433 substituted with Phosphothreonine" [UniProtKB:Q9UQ88] comment: By similarity xref: UniProtKB:Q9UQ88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002241 ! CD2L2_HUMAN [Term] id: CCO:B0011028 name: CD2L2_HUMAN-Phosphotyrosine434 def: "Protein CD2L2_HUMAN with the residue 434 substituted with Phosphotyrosine" [UniProtKB:Q9UQ88] comment: By similarity xref: UniProtKB:Q9UQ88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002241 ! CD2L2_HUMAN [Term] id: CCO:B0011029 name: CD2L2_HUMAN-Phosphothreonine580 def: "Protein CD2L2_HUMAN with the residue 580 substituted with Phosphothreonine" [UniProtKB:Q9UQ88] comment: By similarity xref: UniProtKB:Q9UQ88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002241 ! CD2L2_HUMAN [Term] id: CCO:B0011030 name: CD2L2_HUMAN-Phosphothreonine736 def: "Protein CD2L2_HUMAN with the residue 736 substituted with Phosphothreonine" [UniProtKB:Q9UQ88] xref: UniProtKB:Q9UQ88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002241 ! CD2L2_HUMAN [Term] id: CCO:B0011031 name: CD2L2_HUMAN-Phosphoserine737 def: "Protein CD2L2_HUMAN with the residue 737 substituted with Phosphoserine" [UniProtKB:Q9UQ88] xref: UniProtKB:Q9UQ88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002241 ! CD2L2_HUMAN [Term] id: CCO:B0011032 name: CD2L5_HUMAN-Phosphoserine315 def: "Protein CD2L5_HUMAN with the residue 315 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011033 name: CD2L5_HUMAN-Phosphoserine317 def: "Protein CD2L5_HUMAN with the residue 317 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011034 name: CD2L5_HUMAN-Phosphoserine325 def: "Protein CD2L5_HUMAN with the residue 325 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011035 name: CD2L5_HUMAN-Phosphoserine340 def: "Protein CD2L5_HUMAN with the residue 340 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011036 name: CD2L5_HUMAN-Phosphoserine342 def: "Protein CD2L5_HUMAN with the residue 342 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011037 name: CD2L5_HUMAN-Phosphoserine367 def: "Protein CD2L5_HUMAN with the residue 367 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011038 name: CD2L5_HUMAN-Phosphoserine383 def: "Protein CD2L5_HUMAN with the residue 383 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011039 name: CD2L5_HUMAN-Phosphoserine395 def: "Protein CD2L5_HUMAN with the residue 395 substituted with Phosphoserine" [UniProtKB:Q14004] comment: By similarity xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011040 name: CD2L5_HUMAN-Phosphoserine397 def: "Protein CD2L5_HUMAN with the residue 397 substituted with Phosphoserine" [UniProtKB:Q14004] comment: By similarity xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011041 name: CD2L5_HUMAN-Phosphoserine400 def: "Protein CD2L5_HUMAN with the residue 400 substituted with Phosphoserine" [UniProtKB:Q14004] comment: By similarity xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011042 name: CD2L5_HUMAN-Phosphoserine436 def: "Protein CD2L5_HUMAN with the residue 436 substituted with Phosphoserine" [UniProtKB:Q14004] comment: By similarity xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011043 name: CD2L5_HUMAN-Phosphoserine437 def: "Protein CD2L5_HUMAN with the residue 437 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011044 name: CD2L5_HUMAN-Phosphoserine439 def: "Protein CD2L5_HUMAN with the residue 439 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011045 name: CD2L5_HUMAN-Phosphoserine441 def: "Protein CD2L5_HUMAN with the residue 441 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011046 name: CD2L5_HUMAN-Phosphothreonine442 def: "Protein CD2L5_HUMAN with the residue 442 substituted with Phosphothreonine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011047 name: CD2L5_HUMAN-Phosphoserine1066 def: "Protein CD2L5_HUMAN with the residue 1066 substituted with Phosphoserine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011048 name: CD2L5_HUMAN-Phosphothreonine1246 def: "Protein CD2L5_HUMAN with the residue 1246 substituted with Phosphothreonine" [UniProtKB:Q14004] xref: UniProtKB:Q14004 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001771 ! CD2L5_HUMAN [Term] id: CCO:B0011049 name: CD45_HUMAN-Phosphoserine995 def: "Protein CD45_HUMAN with the residue 995 substituted with Phosphoserine" [UniProtKB:P08575] xref: UniProtKB:P08575 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001499 ! CD45_HUMAN [Term] id: CCO:B0011050 name: CD45_HUMAN-Phosphoserine1003 def: "Protein CD45_HUMAN with the residue 1003 substituted with Phosphoserine" [UniProtKB:P08575] xref: UniProtKB:P08575 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001499 ! CD45_HUMAN [Term] id: CCO:B0011051 name: CD45_HUMAN-Phosphoserine1007 def: "Protein CD45_HUMAN with the residue 1007 substituted with Phosphoserine" [UniProtKB:P08575] xref: UniProtKB:P08575 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001499 ! CD45_HUMAN [Term] id: CCO:B0011052 name: CDC16_HUMAN-Phosphoserine112 def: "Protein CDC16_HUMAN with the residue 112 substituted with Phosphoserine" [UniProtKB:Q13042] xref: UniProtKB:Q13042 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001739 ! CDC16_HUMAN [Term] id: CCO:B0011053 name: CDC16_HUMAN-Phosphoserine490 def: "Protein CDC16_HUMAN with the residue 490 substituted with Phosphoserine" [UniProtKB:Q13042] xref: UniProtKB:Q13042 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001739 ! CDC16_HUMAN [Term] id: CCO:B0011054 name: CDC16_HUMAN-Phosphoserine560 def: "Protein CDC16_HUMAN with the residue 560 substituted with Phosphoserine" [UniProtKB:Q13042] xref: UniProtKB:Q13042 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001739 ! CDC16_HUMAN [Term] id: CCO:B0011055 name: CDC16_HUMAN-Phosphothreonine581 def: "Protein CDC16_HUMAN with the residue 581 substituted with Phosphothreonine" [UniProtKB:Q13042] xref: UniProtKB:Q13042 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001739 ! CDC16_HUMAN [Term] id: CCO:B0011056 name: CDC16_HUMAN-Phosphoserine595 def: "Protein CDC16_HUMAN with the residue 595 substituted with Phosphoserine" [UniProtKB:Q13042] xref: UniProtKB:Q13042 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001739 ! CDC16_HUMAN [Term] id: CCO:B0011057 name: CDC16_HUMAN-Phosphothreonine599 def: "Protein CDC16_HUMAN with the residue 599 substituted with Phosphothreonine" [UniProtKB:Q13042] xref: UniProtKB:Q13042 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001739 ! CDC16_HUMAN [Term] id: CCO:B0011058 name: CDC20_HUMAN-Phosphothreonine70 def: "Protein CDC20_HUMAN with the residue 70 substituted with Phosphothreonine" [UniProtKB:Q12834] xref: UniProtKB:Q12834 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001733 ! CDC20_HUMAN [Term] id: CCO:B0011059 name: CDC20_HUMAN-Phosphothreonine106 def: "Protein CDC20_HUMAN with the residue 106 substituted with Phosphothreonine" [UniProtKB:Q12834] xref: UniProtKB:Q12834 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001733 ! CDC20_HUMAN [Term] id: CCO:B0011060 name: CDC23_HUMAN-Phosphotyrosine267 def: "Protein CDC23_HUMAN with the residue 267 substituted with Phosphotyrosine" [UniProtKB:Q9UJX2] xref: UniProtKB:Q9UJX2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002212 ! CDC23_HUMAN [Term] id: CCO:B0011061 name: CDC23_HUMAN-Phosphothreonine556 def: "Protein CDC23_HUMAN with the residue 556 substituted with Phosphothreonine" [UniProtKB:Q9UJX2] xref: UniProtKB:Q9UJX2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002212 ! CDC23_HUMAN [Term] id: CCO:B0011062 name: CDC23_HUMAN-Phosphothreonine559 def: "Protein CDC23_HUMAN with the residue 559 substituted with Phosphothreonine" [UniProtKB:Q9UJX2] xref: UniProtKB:Q9UJX2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0001633 ! binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000282 ! anaphase-promoting complex relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0002212 ! CDC23_HUMAN [Term] id: CCO:B0011063 name: CDC23_HUMAN-Phosphoserine572 def: "Protein CDC23_HUMAN with the residue 572 substituted with Phosphoserine" [UniProtKB:Q9UJX2] comment: By similarity xref: UniProtKB:Q9UJX2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002212 ! CDC23_HUMAN [Term] id: CCO:B0011064 name: CDC23_HUMAN-Phosphoserine582 def: "Protein CDC23_HUMAN with the residue 582 substituted with Phosphoserine" [UniProtKB:Q9UJX2] xref: UniProtKB:Q9UJX2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002212 ! CDC23_HUMAN [Term] id: CCO:B0011065 name: CDC23_HUMAN-Phosphothreonine590 def: "Protein CDC23_HUMAN with the residue 590 substituted with Phosphothreonine" [UniProtKB:Q9UJX2] xref: UniProtKB:Q9UJX2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002212 ! CDC23_HUMAN [Term] id: CCO:B0011066 name: CDC26_HUMAN-Phosphoserine78 def: "Protein CDC26_HUMAN with the residue 78 substituted with Phosphoserine" [UniProtKB:Q8NHZ8] xref: UniProtKB:Q8NHZ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000282 ! anaphase-promoting complex relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0001986 ! CDC26_HUMAN [Term] id: CCO:B0011067 name: CDC26_HUMAN-Phosphoserine82 def: "Protein CDC26_HUMAN with the residue 82 substituted with Phosphoserine" [UniProtKB:Q8NHZ8] xref: UniProtKB:Q8NHZ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001986 ! CDC26_HUMAN [Term] id: CCO:B0011068 name: CDC27_HUMAN-Phosphothreonine205 def: "Protein CDC27_HUMAN with the residue 205 substituted with Phosphothreonine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011069 name: CDC27_HUMAN-Phosphothreonine209 def: "Protein CDC27_HUMAN with the residue 209 substituted with Phosphothreonine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011070 name: CDC27_HUMAN-Phosphothreonine244 def: "Protein CDC27_HUMAN with the residue 244 substituted with Phosphothreonine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011071 name: CDC27_HUMAN-Phosphoserine291 def: "Protein CDC27_HUMAN with the residue 291 substituted with Phosphoserine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011072 name: CDC27_HUMAN-Phosphothreonine313 def: "Protein CDC27_HUMAN with the residue 313 substituted with Phosphothreonine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011073 name: CDC27_HUMAN-Phosphoserine426 def: "Protein CDC27_HUMAN with the residue 426 substituted with Phosphoserine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011074 name: CDC27_HUMAN-Phosphothreonine430 def: "Protein CDC27_HUMAN with the residue 430 substituted with Phosphothreonine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000282 ! anaphase-promoting complex relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0000436 ! spindle microtubule relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011075 name: CDC27_HUMAN-Phosphoserine435 def: "Protein CDC27_HUMAN with the residue 435 substituted with Phosphoserine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011076 name: CDC27_HUMAN-Phosphoserine438 def: "Protein CDC27_HUMAN with the residue 438 substituted with Phosphoserine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011077 name: CDC27_HUMAN-Phosphothreonine446 def: "Protein CDC27_HUMAN with the residue 446 substituted with Phosphothreonine" [UniProtKB:P30260] xref: UniProtKB:P30260 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001572 ! CDC27_HUMAN [Term] id: CCO:B0011078 name: CDC2_HUMAN-Phosphothreonine14 def: "Protein CDC2_HUMAN with the residue 14 substituted with Phosphothreonine" [UniProtKB:P06493] xref: UniProtKB:P06493 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001493 ! CDC2_HUMAN [Term] id: CCO:B0011079 name: CDC2_HUMAN-Phosphotyrosine15 def: "Protein CDC2_HUMAN with the residue 15 substituted with Phosphotyrosine" [UniProtKB:P06493] xref: UniProtKB:P06493 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001493 ! CDC2_HUMAN [Term] id: CCO:B0011080 name: CDC2_HUMAN-Phosphotyrosine19 def: "Protein CDC2_HUMAN with the residue 19 substituted with Phosphotyrosine" [UniProtKB:P06493] xref: UniProtKB:P06493 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001493 ! CDC2_HUMAN [Term] id: CCO:B0011081 name: CDC2_HUMAN-Phosphothreonine161 def: "Protein CDC2_HUMAN with the residue 161 substituted with Phosphothreonine" [UniProtKB:P06493] xref: UniProtKB:P06493 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001493 ! CDC2_HUMAN [Term] id: CCO:B0011082 name: CDC37_HUMAN-Phosphotyrosine298 def: "Protein CDC37_HUMAN with the residue 298 substituted with Phosphotyrosine" [UniProtKB:Q16543] xref: UniProtKB:Q16543 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0008055 ! unfolded protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001819 ! CDC37_HUMAN [Term] id: CCO:B0011083 name: CDC42_HUMAN-Cysteine methyl ester188 def: "Protein CDC42_HUMAN with the residue 188 substituted with Cysteine methyl ester" [UniProtKB:P60953] xref: UniProtKB:P60953 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:B0011084 name: CDC5L_HUMAN-Phosphoserine303 def: "Protein CDC5L_HUMAN with the residue 303 substituted with Phosphoserine" [UniProtKB:Q99459] xref: UniProtKB:Q99459 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002065 ! CDC5L_HUMAN [Term] id: CCO:B0011085 name: CDC5L_HUMAN-Phosphothreonine385 def: "Protein CDC5L_HUMAN with the residue 385 substituted with Phosphothreonine" [UniProtKB:Q99459] comment: By similarity xref: UniProtKB:Q99459 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002065 ! CDC5L_HUMAN [Term] id: CCO:B0011086 name: CDC5L_HUMAN-Phosphothreonine396 def: "Protein CDC5L_HUMAN with the residue 396 substituted with Phosphothreonine" [UniProtKB:Q99459] comment: By similarity xref: UniProtKB:Q99459 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002065 ! CDC5L_HUMAN [Term] id: CCO:B0011087 name: CDC6_HUMAN-Phosphothreonine166 def: "Protein CDC6_HUMAN with the residue 166 substituted with Phosphothreonine" [UniProtKB:Q99741] xref: UniProtKB:Q99741 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003574 ! nucleoside-triphosphatase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0002087 ! CDC6_HUMAN [Term] id: CCO:B0011088 name: CDCA2_HUMAN-Phosphoserine99 def: "Protein CDCA2_HUMAN with the residue 99 substituted with Phosphoserine" [UniProtKB:Q69YH5] xref: UniProtKB:Q69YH5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001905 ! CDCA2_HUMAN [Term] id: CCO:B0011089 name: CDCA2_HUMAN-Phosphoserine292 def: "Protein CDCA2_HUMAN with the residue 292 substituted with Phosphoserine" [UniProtKB:Q69YH5] xref: UniProtKB:Q69YH5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001905 ! CDCA2_HUMAN [Term] id: CCO:B0011090 name: CDCA2_HUMAN-Phosphoserine336 def: "Protein CDCA2_HUMAN with the residue 336 substituted with Phosphoserine" [UniProtKB:Q69YH5] xref: UniProtKB:Q69YH5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001905 ! CDCA2_HUMAN [Term] id: CCO:B0011091 name: CDCA2_HUMAN-Phosphoserine401 def: "Protein CDCA2_HUMAN with the residue 401 substituted with Phosphoserine" [UniProtKB:Q69YH5] xref: UniProtKB:Q69YH5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001905 ! CDCA2_HUMAN [Term] id: CCO:B0011092 name: CDCA3_HUMAN-Phosphoserine68 def: "Protein CDCA3_HUMAN with the residue 68 substituted with Phosphoserine" [UniProtKB:Q99618] xref: UniProtKB:Q99618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000272 ! molecular_function relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0002076 ! CDCA3_HUMAN [Term] id: CCO:B0011093 name: CDCA3_HUMAN-Phosphothreonine159 def: "Protein CDCA3_HUMAN with the residue 159 substituted with Phosphothreonine" [UniProtKB:Q99618] xref: UniProtKB:Q99618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002076 ! CDCA3_HUMAN [Term] id: CCO:B0011094 name: CDCA3_HUMAN-Phosphoserine165 def: "Protein CDCA3_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:Q99618] xref: UniProtKB:Q99618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002076 ! CDCA3_HUMAN [Term] id: CCO:B0011095 name: CDCA3_HUMAN-Phosphothreonine177 def: "Protein CDCA3_HUMAN with the residue 177 substituted with Phosphothreonine" [UniProtKB:Q99618] xref: UniProtKB:Q99618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002076 ! CDCA3_HUMAN [Term] id: CCO:B0011096 name: CDCA3_HUMAN-Phosphoserine199 def: "Protein CDCA3_HUMAN with the residue 199 substituted with Phosphoserine" [UniProtKB:Q99618] xref: UniProtKB:Q99618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002076 ! CDCA3_HUMAN [Term] id: CCO:B0011097 name: CDCA3_HUMAN-Phosphoserine209 def: "Protein CDCA3_HUMAN with the residue 209 substituted with Phosphoserine" [UniProtKB:Q99618] xref: UniProtKB:Q99618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002076 ! CDCA3_HUMAN [Term] id: CCO:B0011098 name: CDCA5_HUMAN-Phosphothreonine48 def: "Protein CDCA5_HUMAN with the residue 48 substituted with Phosphothreonine" [UniProtKB:Q96FF9] xref: UniProtKB:Q96FF9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000278 ! chromatin binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000538 ! cohesin complex relationship: transformation_of CCO:B0002038 ! CDCA5_HUMAN [Term] id: CCO:B0011099 name: CDCA5_HUMAN-Phosphoserine50 def: "Protein CDCA5_HUMAN with the residue 50 substituted with Phosphoserine" [UniProtKB:Q96FF9] xref: UniProtKB:Q96FF9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002038 ! CDCA5_HUMAN [Term] id: CCO:B0011100 name: CDCA5_HUMAN-Phosphoserine75 def: "Protein CDCA5_HUMAN with the residue 75 substituted with Phosphoserine" [UniProtKB:Q96FF9] xref: UniProtKB:Q96FF9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002038 ! CDCA5_HUMAN [Term] id: CCO:B0011101 name: CDCA5_HUMAN-Phosphoserine79 def: "Protein CDCA5_HUMAN with the residue 79 substituted with Phosphoserine" [UniProtKB:Q96FF9] xref: UniProtKB:Q96FF9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002038 ! CDCA5_HUMAN [Term] id: CCO:B0011102 name: CDK10_HUMAN-Phosphothreonine196 def: "Protein CDK10_HUMAN with the residue 196 substituted with Phosphothreonine" [UniProtKB:Q15131] xref: UniProtKB:Q15131 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001803 ! CDK10_HUMAN [Term] id: CCO:B0011103 name: CDK2_HUMAN-Phosphothreonine14 def: "Protein CDK2_HUMAN with the residue 14 substituted with Phosphothreonine" [UniProtKB:P24941] xref: UniProtKB:P24941 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:B0011104 name: CDK2_HUMAN-Phosphotyrosine15 def: "Protein CDK2_HUMAN with the residue 15 substituted with Phosphotyrosine" [UniProtKB:P24941] comment: by WEE1; xref: UniProtKB:P24941 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:B0011105 name: CDK2_HUMAN-Phosphotyrosine19 def: "Protein CDK2_HUMAN with the residue 19 substituted with Phosphotyrosine" [UniProtKB:P24941] xref: UniProtKB:P24941 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001060 ! cyclin-dependent protein kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0005564 ! histone kinase activity relationship: has_function CCO:F0005713 ! identical protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000053 ! cyclin-dependent protein kinase holoenzyme complex relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:B0011106 name: CDK2_HUMAN-Phosphothreonine160 def: "Protein CDK2_HUMAN with the residue 160 substituted with Phosphothreonine" [UniProtKB:P24941] comment: by CAK and CCRK; xref: UniProtKB:P24941 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:B0011107 name: CDK3_HUMAN-Phosphothreonine14 def: "Protein CDK3_HUMAN with the residue 14 substituted with Phosphothreonine" [UniProtKB:Q00526] xref: UniProtKB:Q00526 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001707 ! CDK3_HUMAN [Term] id: CCO:B0011108 name: CDK3_HUMAN-Phosphotyrosine15 def: "Protein CDK3_HUMAN with the residue 15 substituted with Phosphotyrosine" [UniProtKB:Q00526] xref: UniProtKB:Q00526 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001707 ! CDK3_HUMAN [Term] id: CCO:B0011109 name: CDK3_HUMAN-Phosphotyrosine19 def: "Protein CDK3_HUMAN with the residue 19 substituted with Phosphotyrosine" [UniProtKB:Q00526] xref: UniProtKB:Q00526 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001707 ! CDK3_HUMAN [Term] id: CCO:B0011110 name: CDK3_HUMAN-Phosphothreonine160 def: "Protein CDK3_HUMAN with the residue 160 substituted with Phosphothreonine" [UniProtKB:Q00526] comment: By similarity xref: UniProtKB:Q00526 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001060 ! cyclin-dependent protein kinase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001707 ! CDK3_HUMAN [Term] id: CCO:B0011111 name: CDK3_HUMAN-Phosphoserine207 def: "Protein CDK3_HUMAN with the residue 207 substituted with Phosphoserine" [UniProtKB:Q00526] xref: UniProtKB:Q00526 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001707 ! CDK3_HUMAN [Term] id: CCO:B0011112 name: CDK4_HUMAN-Phosphothreonine172 def: "Protein CDK4_HUMAN with the residue 172 substituted with Phosphothreonine" [UniProtKB:P11802] comment: by CAK; By similarity xref: UniProtKB:P11802 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001512 ! CDK4_HUMAN [Term] id: CCO:B0011113 name: CDK5_HUMAN-Phosphothreonine14 def: "Protein CDK5_HUMAN with the residue 14 substituted with Phosphothreonine" [UniProtKB:Q00535] comment: By similarity xref: UniProtKB:Q00535 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001709 ! CDK5_HUMAN [Term] id: CCO:B0011114 name: CDK5_HUMAN-Phosphotyrosine15 def: "Protein CDK5_HUMAN with the residue 15 substituted with Phosphotyrosine" [UniProtKB:Q00535] comment: by ABL1; By similarity xref: UniProtKB:Q00535 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001709 ! CDK5_HUMAN [Term] id: CCO:B0011115 name: CDK5_HUMAN-Phosphoserine159 def: "Protein CDK5_HUMAN with the residue 159 substituted with Phosphoserine" [UniProtKB:Q00535] comment: By similarity xref: UniProtKB:Q00535 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001060 ! cyclin-dependent protein kinase activity relationship: has_function CCO:F0001477 ! ErbB-2 class receptor binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0004461 ! acetylcholine receptor activator activity relationship: has_function CCO:F0005796 ! ErbB-3 class receptor binding relationship: has_function CCO:F0007673 ! tau-protein kinase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0001004 ! axon relationship: located_in CCO:C0001005 ! dendrite relationship: located_in CCO:C0001006 ! growth cone relationship: located_in CCO:C0001300 ! neuromuscular junction relationship: located_in CCO:C0001706 ! cell projection relationship: located_in CCO:C0001709 ! cell soma relationship: transformation_of CCO:B0001709 ! CDK5_HUMAN [Term] id: CCO:B0011116 name: CDK6_HUMAN-Phosphotyrosine13 def: "Protein CDK6_HUMAN with the residue 13 substituted with Phosphotyrosine" [UniProtKB:Q00534] xref: UniProtKB:Q00534 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:B0011117 name: CDK6_HUMAN-Phosphotyrosine24 def: "Protein CDK6_HUMAN with the residue 24 substituted with Phosphotyrosine" [UniProtKB:Q00534] xref: UniProtKB:Q00534 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:B0011118 name: CDK7_HUMAN-Phosphoserine164 def: "Protein CDK7_HUMAN with the residue 164 substituted with Phosphoserine" [UniProtKB:P50613] xref: UniProtKB:P50613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001644 ! CDK7_HUMAN [Term] id: CCO:B0011119 name: CDK7_HUMAN-Phosphothreonine170 def: "Protein CDK7_HUMAN with the residue 170 substituted with Phosphothreonine" [UniProtKB:P50613] xref: UniProtKB:P50613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001644 ! CDK7_HUMAN [Term] id: CCO:B0011121 name: CDN1A_HUMAN-N-acetylserine2 def: "Protein CDN1A_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P38936] xref: UniProtKB:P38936 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:B0011122 name: CDN1A_HUMAN-Phosphoserine130 def: "Protein CDN1A_HUMAN with the residue 130 substituted with Phosphoserine" [UniProtKB:P38936] xref: UniProtKB:P38936 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:B0011123 name: CDN1A_HUMAN-Phosphothreonine145 def: "Protein CDN1A_HUMAN with the residue 145 substituted with Phosphothreonine" [UniProtKB:P38936] comment: by PKA and PKB/AKT1; xref: UniProtKB:P38936 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:B0011124 name: CDN1A_HUMAN-Phosphoserine146 def: "Protein CDN1A_HUMAN with the residue 146 substituted with Phosphoserine" [UniProtKB:P38936] comment: by PKC; xref: UniProtKB:P38936 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:B0011125 name: CDN1A_HUMAN-Phosphoserine160 def: "Protein CDN1A_HUMAN with the residue 160 substituted with Phosphoserine" [UniProtKB:P38936] comment: by PKC; in vitro; xref: UniProtKB:P38936 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:B0011126 name: CDN1B_HUMAN-Phosphoserine10 def: "Protein CDN1B_HUMAN with the residue 10 substituted with Phosphoserine" [UniProtKB:P46527] comment: by UHMK1; xref: UniProtKB:P46527 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:B0011127 name: CDN1B_HUMAN-Phosphoserine140 def: "Protein CDN1B_HUMAN with the residue 140 substituted with Phosphoserine" [UniProtKB:P46527] xref: UniProtKB:P46527 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001216 ! protein kinase inhibitor activity relationship: has_function CCO:F0001217 ! cyclin-dependent protein kinase inhibitor activity relationship: has_function CCO:F0001382 ! transforming growth factor beta receptor, cytoplasmic mediator activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:B0011128 name: CDN2D_HUMAN-N-acetylmethionine1 def: "Protein CDN2D_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P55273] xref: UniProtKB:P55273 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001675 ! CDN2D_HUMAN [Term] id: CCO:B0011129 name: CDT1_HUMAN-Phosphoserine318 def: "Protein CDT1_HUMAN with the residue 318 substituted with Phosphoserine" [UniProtKB:Q9H211] xref: UniProtKB:Q9H211 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002126 ! CDT1_HUMAN [Term] id: CCO:B0011130 name: CE110_HUMAN-Phosphoserine641 def: "Protein CE110_HUMAN with the residue 641 substituted with Phosphoserine" [UniProtKB:O43303] xref: UniProtKB:O43303 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001389 ! CE110_HUMAN [Term] id: CCO:B0011132 name: CELR3_HUMAN-3-hydroxyaspartate1963 def: "Protein CELR3_HUMAN with the residue 1963 substituted with 3-hydroxyaspartate" [UniProtKB:Q9NYQ7] comment: Potential xref: UniProtKB:Q9NYQ7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005546 ! CELR3_HUMAN [Term] id: CCO:B0011133 name: CEND2_HUMAN-Phosphothreonine114 def: "Protein CEND2_HUMAN with the residue 114 substituted with Phosphothreonine" [UniProtKB:Q96P48] xref: UniProtKB:Q96P48 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002052 ! CEND2_HUMAN [Term] id: CCO:B0011134 name: CEND2_HUMAN-Phosphotyrosine497 def: "Protein CEND2_HUMAN with the residue 497 substituted with Phosphotyrosine" [UniProtKB:Q96P48] xref: UniProtKB:Q96P48 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002052 ! CEND2_HUMAN [Term] id: CCO:B0011135 name: CENPB_HUMAN-Phosphoserine156 def: "Protein CENPB_HUMAN with the residue 156 substituted with Phosphoserine" [UniProtKB:P07199] xref: UniProtKB:P07199 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005431 ! CENPB_HUMAN [Term] id: CCO:B0011136 name: CENPB_HUMAN-Phosphoserine165 def: "Protein CENPB_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:P07199] xref: UniProtKB:P07199 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005431 ! CENPB_HUMAN [Term] id: CCO:B0011146 name: CENPE_HUMAN-Phosphothreonine422 def: "Protein CENPE_HUMAN with the residue 422 substituted with Phosphothreonine" [UniProtKB:Q02224] xref: UniProtKB:Q02224 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001715 ! CENPE_HUMAN [Term] id: CCO:B0011147 name: CENPE_HUMAN-Phosphoserine454 def: "Protein CENPE_HUMAN with the residue 454 substituted with Phosphoserine" [UniProtKB:Q02224] xref: UniProtKB:Q02224 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000321 ! motor activity relationship: has_function CCO:F0000322 ! microtubule motor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0005864 ! kinetochore binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: located_in CCO:C0000159 ! outer kinetochore of condensed chromosome relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000434 ! microtubule relationship: located_in CCO:C0000435 ! microtubule associated complex relationship: transformation_of CCO:B0001715 ! CENPE_HUMAN [Term] id: CCO:B0011148 name: CENPE_HUMAN-Phosphothreonine544 def: "Protein CENPE_HUMAN with the residue 544 substituted with Phosphothreonine" [UniProtKB:Q02224] xref: UniProtKB:Q02224 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001715 ! CENPE_HUMAN [Term] id: CCO:B0011149 name: CENPE_HUMAN-Phosphoserine611 def: "Protein CENPE_HUMAN with the residue 611 substituted with Phosphoserine" [UniProtKB:Q02224] xref: UniProtKB:Q02224 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001715 ! CENPE_HUMAN [Term] id: CCO:B0011150 name: CENPE_HUMAN-Phosphoserine1211 def: "Protein CENPE_HUMAN with the residue 1211 substituted with Phosphoserine" [UniProtKB:Q02224] xref: UniProtKB:Q02224 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001715 ! CENPE_HUMAN [Term] id: CCO:B0011151 name: CENPE_HUMAN-Phosphothreonine1268 def: "Protein CENPE_HUMAN with the residue 1268 substituted with Phosphothreonine" [UniProtKB:Q02224] xref: UniProtKB:Q02224 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001715 ! CENPE_HUMAN [Term] id: CCO:B0011152 name: CENPE_HUMAN-Phosphoserine2639 def: "Protein CENPE_HUMAN with the residue 2639 substituted with Phosphoserine" [UniProtKB:Q02224] xref: UniProtKB:Q02224 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001715 ! CENPE_HUMAN [Term] id: CCO:B0011153 name: CENPE_HUMAN-Phosphoserine2651 def: "Protein CENPE_HUMAN with the residue 2651 substituted with Phosphoserine" [UniProtKB:Q02224] xref: UniProtKB:Q02224 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001715 ! CENPE_HUMAN [Term] id: CCO:B0011154 name: CENPE_HUMAN-Phosphoserine2654 def: "Protein CENPE_HUMAN with the residue 2654 substituted with Phosphoserine" [UniProtKB:Q02224] xref: UniProtKB:Q02224 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001715 ! CENPE_HUMAN [Term] id: CCO:B0011155 name: CENPF_HUMAN-Phosphoserine268 def: "Protein CENPF_HUMAN with the residue 268 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011156 name: CENPF_HUMAN-Phosphoserine274 def: "Protein CENPF_HUMAN with the residue 274 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011157 name: CENPF_HUMAN-Phosphoserine276 def: "Protein CENPF_HUMAN with the residue 276 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011158 name: CENPF_HUMAN-Phosphoserine821 def: "Protein CENPF_HUMAN with the residue 821 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011159 name: CENPF_HUMAN-Phosphoserine1255 def: "Protein CENPF_HUMAN with the residue 1255 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011160 name: CENPF_HUMAN-Phosphoserine1282 def: "Protein CENPF_HUMAN with the residue 1282 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011161 name: CENPF_HUMAN-Phosphotyrosine1315 def: "Protein CENPF_HUMAN with the residue 1315 substituted with Phosphotyrosine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011162 name: CENPF_HUMAN-Phosphothreonine1319 def: "Protein CENPF_HUMAN with the residue 1319 substituted with Phosphothreonine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011163 name: CENPF_HUMAN-Phosphoserine1324 def: "Protein CENPF_HUMAN with the residue 1324 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011164 name: CENPF_HUMAN-Phosphoserine1747 def: "Protein CENPF_HUMAN with the residue 1747 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011165 name: CENPF_HUMAN-Phosphoserine1750 def: "Protein CENPF_HUMAN with the residue 1750 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011166 name: CENPF_HUMAN-Phosphoserine1988 def: "Protein CENPF_HUMAN with the residue 1988 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011167 name: CENPF_HUMAN-Phosphoserine2513 def: "Protein CENPF_HUMAN with the residue 2513 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011168 name: CENPF_HUMAN-Phosphoserine2638 def: "Protein CENPF_HUMAN with the residue 2638 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011169 name: CENPF_HUMAN-Phosphoserine2996 def: "Protein CENPF_HUMAN with the residue 2996 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011170 name: CENPF_HUMAN-Phosphoserine3007 def: "Protein CENPF_HUMAN with the residue 3007 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011171 name: CENPF_HUMAN-Phosphoserine3094 def: "Protein CENPF_HUMAN with the residue 3094 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011172 name: CENPF_HUMAN-Phosphoserine3119 def: "Protein CENPF_HUMAN with the residue 3119 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011173 name: CENPF_HUMAN-Phosphoserine3150 def: "Protein CENPF_HUMAN with the residue 3150 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011174 name: CENPF_HUMAN-Phosphoserine3175 def: "Protein CENPF_HUMAN with the residue 3175 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011175 name: CENPF_HUMAN-Phosphoserine3179 def: "Protein CENPF_HUMAN with the residue 3179 substituted with Phosphoserine" [UniProtKB:P49454] xref: UniProtKB:P49454 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001629 ! CENPF_HUMAN [Term] id: CCO:B0011176 name: CENPJ_HUMAN-Phosphoserine1109 def: "Protein CENPJ_HUMAN with the residue 1109 substituted with Phosphoserine" [UniProtKB:Q9HC77] xref: UniProtKB:Q9HC77 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005426 ! CENPJ_HUMAN [Term] id: CCO:B0011177 name: CENPR_HUMAN-Phosphoserine28 def: "Protein CENPR_HUMAN with the residue 28 substituted with Phosphoserine" [UniProtKB:Q13352] comment: Probable xref: UniProtKB:Q13352 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006198 ! CENPR_HUMAN [Term] id: CCO:B0011178 name: CEP55_HUMAN-Phosphoserine425 def: "Protein CEP55_HUMAN with the residue 425 substituted with Phosphoserine" [UniProtKB:Q53EZ4] comment: by CDC2 and MAPK1; xref: UniProtKB:Q53EZ4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001837 ! CEP55_HUMAN [Term] id: CCO:B0011179 name: CEP55_HUMAN-Phosphoserine428 def: "Protein CEP55_HUMAN with the residue 428 substituted with Phosphoserine" [UniProtKB:Q53EZ4] comment: by CDC2 and MAPK1; xref: UniProtKB:Q53EZ4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001837 ! CEP55_HUMAN [Term] id: CCO:B0011180 name: CEP55_HUMAN-Phosphoserine436 def: "Protein CEP55_HUMAN with the residue 436 substituted with Phosphoserine" [UniProtKB:Q53EZ4] comment: by PLK1; xref: UniProtKB:Q53EZ4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001837 ! CEP55_HUMAN [Term] id: CCO:B0011181 name: CETN2_HUMAN-Phosphoserine20 def: "Protein CETN2_HUMAN with the residue 20 substituted with Phosphoserine" [UniProtKB:P41208] xref: UniProtKB:P41208 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001604 ! CETN2_HUMAN [Term] id: CCO:B0011182 name: CETN2_HUMAN-Phosphothreonine26 def: "Protein CETN2_HUMAN with the residue 26 substituted with Phosphothreonine" [UniProtKB:P41208] xref: UniProtKB:P41208 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001604 ! CETN2_HUMAN [Term] id: CCO:B0011183 name: CFTR_HUMAN-Phosphoserine660 def: "Protein CFTR_HUMAN with the residue 660 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKA; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011184 name: CFTR_HUMAN-Phosphoserine686 def: "Protein CFTR_HUMAN with the residue 686 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKC; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011185 name: CFTR_HUMAN-Phosphoserine700 def: "Protein CFTR_HUMAN with the residue 700 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKA; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011186 name: CFTR_HUMAN-Phosphoserine712 def: "Protein CFTR_HUMAN with the residue 712 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKA; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011187 name: CFTR_HUMAN-Phosphoserine737 def: "Protein CFTR_HUMAN with the residue 737 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKA; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011188 name: CFTR_HUMAN-Phosphoserine753 def: "Protein CFTR_HUMAN with the residue 753 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKA; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011189 name: CFTR_HUMAN-Phosphoserine768 def: "Protein CFTR_HUMAN with the residue 768 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKA; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011190 name: CFTR_HUMAN-Phosphoserine790 def: "Protein CFTR_HUMAN with the residue 790 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKC; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011191 name: CFTR_HUMAN-Phosphoserine795 def: "Protein CFTR_HUMAN with the residue 795 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKA; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011192 name: CFTR_HUMAN-Phosphoserine813 def: "Protein CFTR_HUMAN with the residue 813 substituted with Phosphoserine" [UniProtKB:P13569] comment: by PKA; xref: UniProtKB:P13569 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:B0011193 name: CG025_HUMAN-Phosphoserine208 def: "Protein CG025_HUMAN with the residue 208 substituted with Phosphoserine" [UniProtKB:Q9BPX7] xref: UniProtKB:Q9BPX7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006330 ! CG025_HUMAN [Term] id: CCO:B0011194 name: CG025_HUMAN-Phosphoserine210 def: "Protein CG025_HUMAN with the residue 210 substituted with Phosphoserine" [UniProtKB:Q9BPX7] xref: UniProtKB:Q9BPX7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006330 ! CG025_HUMAN [Term] id: CCO:B0011195 name: CG025_HUMAN-Phosphoserine212 def: "Protein CG025_HUMAN with the residue 212 substituted with Phosphoserine" [UniProtKB:Q9BPX7] xref: UniProtKB:Q9BPX7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006330 ! CG025_HUMAN [Term] id: CCO:B0011196 name: CH10_HUMAN-N-acetylalanine2 def: "Protein CH10_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P61604] xref: UniProtKB:P61604 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006092 ! CH10_HUMAN [Term] id: CCO:B0011197 name: CH60_HUMAN-Phosphoserine70 def: "Protein CH60_HUMAN with the residue 70 substituted with Phosphoserine" [UniProtKB:P10809] xref: UniProtKB:P10809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005730 ! CH60_HUMAN [Term] id: CCO:B0011198 name: CH60_HUMAN-Phosphotyrosine223 def: "Protein CH60_HUMAN with the residue 223 substituted with Phosphotyrosine" [UniProtKB:P10809] comment: By similarity xref: UniProtKB:P10809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005730 ! CH60_HUMAN [Term] id: CCO:B0011199 name: CH60_HUMAN-Phosphotyrosine227 def: "Protein CH60_HUMAN with the residue 227 substituted with Phosphotyrosine" [UniProtKB:P10809] xref: UniProtKB:P10809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005730 ! CH60_HUMAN [Term] id: CCO:B0011200 name: CHD3_HUMAN-Phosphoserine324 def: "Protein CHD3_HUMAN with the residue 324 substituted with Phosphoserine" [UniProtKB:Q12873] xref: UniProtKB:Q12873 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006082 ! CHD3_HUMAN [Term] id: CCO:B0011201 name: CHD3_HUMAN-Phosphoserine713 def: "Protein CHD3_HUMAN with the residue 713 substituted with Phosphoserine" [UniProtKB:Q12873] xref: UniProtKB:Q12873 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006082 ! CHD3_HUMAN [Term] id: CCO:B0011202 name: CHD3_HUMAN-Phosphoserine1601 def: "Protein CHD3_HUMAN with the residue 1601 substituted with Phosphoserine" [UniProtKB:Q12873] xref: UniProtKB:Q12873 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006082 ! CHD3_HUMAN [Term] id: CCO:B0011203 name: CHD3_HUMAN-Phosphoserine1605 def: "Protein CHD3_HUMAN with the residue 1605 substituted with Phosphoserine" [UniProtKB:Q12873] xref: UniProtKB:Q12873 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006082 ! CHD3_HUMAN [Term] id: CCO:B0011204 name: CHD8_HUMAN-Phosphothreonine258 def: "Protein CHD8_HUMAN with the residue 258 substituted with Phosphothreonine" [UniProtKB:Q9HCK8] xref: UniProtKB:Q9HCK8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005444 ! CHD8_HUMAN [Term] id: CCO:B0011205 name: CHD8_HUMAN-Phosphothreonine1119 def: "Protein CHD8_HUMAN with the residue 1119 substituted with Phosphothreonine" [UniProtKB:Q9HCK8] xref: UniProtKB:Q9HCK8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005444 ! CHD8_HUMAN [Term] id: CCO:B0011206 name: CHD8_HUMAN-Phosphoserine1141 def: "Protein CHD8_HUMAN with the residue 1141 substituted with Phosphoserine" [UniProtKB:Q9HCK8] xref: UniProtKB:Q9HCK8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005444 ! CHD8_HUMAN [Term] id: CCO:B0011207 name: CHD8_HUMAN-Phosphoserine1145 def: "Protein CHD8_HUMAN with the residue 1145 substituted with Phosphoserine" [UniProtKB:Q9HCK8] xref: UniProtKB:Q9HCK8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005444 ! CHD8_HUMAN [Term] id: CCO:B0011208 name: CHD8_HUMAN-Phosphoserine1790 def: "Protein CHD8_HUMAN with the residue 1790 substituted with Phosphoserine" [UniProtKB:Q9HCK8] xref: UniProtKB:Q9HCK8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005444 ! CHD8_HUMAN [Term] id: CCO:B0011209 name: CHD8_HUMAN-Phosphoserine1792 def: "Protein CHD8_HUMAN with the residue 1792 substituted with Phosphoserine" [UniProtKB:Q9HCK8] xref: UniProtKB:Q9HCK8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005444 ! CHD8_HUMAN [Term] id: CCO:B0011210 name: CHFR_HUMAN-Phosphothreonine130 def: "Protein CHFR_HUMAN with the residue 130 substituted with Phosphothreonine" [UniProtKB:Q96EP1] comment: By similarity xref: UniProtKB:Q96EP1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002035 ! CHFR_HUMAN [Term] id: CCO:B0011211 name: CHFR_HUMAN-Phosphothreonine386 def: "Protein CHFR_HUMAN with the residue 386 substituted with Phosphothreonine" [UniProtKB:Q96EP1] comment: By similarity xref: UniProtKB:Q96EP1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002035 ! CHFR_HUMAN [Term] id: CCO:B0011212 name: CHK1_HUMAN-Phosphoserine280 def: "Protein CHK1_HUMAN with the residue 280 substituted with Phosphoserine" [UniProtKB:O14757] comment: by PKB/AKT1; By similarity xref: UniProtKB:O14757 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001359 ! CHK1_HUMAN [Term] id: CCO:B0011213 name: CHK1_HUMAN-Phosphoserine296 def: "Protein CHK1_HUMAN with the residue 296 substituted with Phosphoserine" [UniProtKB:O14757] xref: UniProtKB:O14757 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000121 ! condensed nuclear chromosome relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001359 ! CHK1_HUMAN [Term] id: CCO:B0011214 name: CHK1_HUMAN-Phosphoserine308 def: "Protein CHK1_HUMAN with the residue 308 substituted with Phosphoserine" [UniProtKB:O14757] xref: UniProtKB:O14757 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001359 ! CHK1_HUMAN [Term] id: CCO:B0011215 name: CHK1_HUMAN-Phosphoserine317 def: "Protein CHK1_HUMAN with the residue 317 substituted with Phosphoserine" [UniProtKB:O14757] comment: by ATM and ATR; xref: UniProtKB:O14757 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001359 ! CHK1_HUMAN [Term] id: CCO:B0011216 name: CHK1_HUMAN-Phosphoserine345 def: "Protein CHK1_HUMAN with the residue 345 substituted with Phosphoserine" [UniProtKB:O14757] comment: by ATM and ATR; xref: UniProtKB:O14757 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001359 ! CHK1_HUMAN [Term] id: CCO:B0011217 name: CHK2_HUMAN-Phosphothreonine68 def: "Protein CHK2_HUMAN with the residue 68 substituted with Phosphothreonine" [UniProtKB:O96017] comment: by MLTK; xref: UniProtKB:O96017 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001459 ! CHK2_HUMAN [Term] id: CCO:B0011218 name: CHSS2_HUMAN-Phosphoserine126 def: "Protein CHSS2_HUMAN with the residue 126 substituted with Phosphoserine" [UniProtKB:Q8IZ52] xref: UniProtKB:Q8IZ52 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006320 ! CHSS2_HUMAN [Term] id: CCO:B0011219 name: CHSS2_HUMAN-Phosphothreonine129 def: "Protein CHSS2_HUMAN with the residue 129 substituted with Phosphothreonine" [UniProtKB:Q8IZ52] xref: UniProtKB:Q8IZ52 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006320 ! CHSS2_HUMAN [Term] id: CCO:B0011225 name: CJ119_HUMAN-Phosphoserine154 def: "Protein CJ119_HUMAN with the residue 154 substituted with Phosphoserine" [UniProtKB:Q9BTE3] xref: UniProtKB:Q9BTE3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005262 ! CJ119_HUMAN [Term] id: CCO:B0011226 name: CJ119_HUMAN-Phosphothreonine160 def: "Protein CJ119_HUMAN with the residue 160 substituted with Phosphothreonine" [UniProtKB:Q9BTE3] xref: UniProtKB:Q9BTE3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005262 ! CJ119_HUMAN [Term] id: CCO:B0011235 name: CKAP2_HUMAN-Phosphoserine534 def: "Protein CKAP2_HUMAN with the residue 534 substituted with Phosphoserine" [UniProtKB:Q8WWK9] xref: UniProtKB:Q8WWK9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002006 ! CKAP2_HUMAN [Term] id: CCO:B0011236 name: CKAP2_HUMAN-Phosphothreonine579 def: "Protein CKAP2_HUMAN with the residue 579 substituted with Phosphothreonine" [UniProtKB:Q8WWK9] xref: UniProtKB:Q8WWK9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002006 ! CKAP2_HUMAN [Term] id: CCO:B0011237 name: CKAP2_HUMAN-Phosphothreonine582 def: "Protein CKAP2_HUMAN with the residue 582 substituted with Phosphothreonine" [UniProtKB:Q8WWK9] xref: UniProtKB:Q8WWK9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002006 ! CKAP2_HUMAN [Term] id: CCO:B0011238 name: CKAP2_HUMAN-Phosphothreonine597 def: "Protein CKAP2_HUMAN with the residue 597 substituted with Phosphothreonine" [UniProtKB:Q8WWK9] xref: UniProtKB:Q8WWK9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002006 ! CKAP2_HUMAN [Term] id: CCO:B0011239 name: CKAP2_HUMAN-Phosphoserine602 def: "Protein CKAP2_HUMAN with the residue 602 substituted with Phosphoserine" [UniProtKB:Q8WWK9] xref: UniProtKB:Q8WWK9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002006 ! CKAP2_HUMAN [Term] id: CCO:B0011240 name: CKAP2_HUMAN-Phosphoserine614 def: "Protein CKAP2_HUMAN with the residue 614 substituted with Phosphoserine" [UniProtKB:Q8WWK9] xref: UniProtKB:Q8WWK9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002006 ! CKAP2_HUMAN [Term] id: CCO:B0011241 name: CKAP2_HUMAN-Phosphothreonine623 def: "Protein CKAP2_HUMAN with the residue 623 substituted with Phosphothreonine" [UniProtKB:Q8WWK9] xref: UniProtKB:Q8WWK9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002006 ! CKAP2_HUMAN [Term] id: CCO:B0011242 name: CKAP4_HUMAN-Phosphoserine17 def: "Protein CKAP4_HUMAN with the residue 17 substituted with Phosphoserine" [UniProtKB:Q07065] xref: UniProtKB:Q07065 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005829 ! CKAP4_HUMAN [Term] id: CCO:B0011243 name: CKAP5_HUMAN-Phosphoserine816 def: "Protein CKAP5_HUMAN with the residue 816 substituted with Phosphoserine" [UniProtKB:Q14008] xref: UniProtKB:Q14008 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000149 ! gamma-tubulin complex relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000754 ! microtubule cytoskeleton relationship: transformation_of CCO:B0001772 ! CKAP5_HUMAN [Term] id: CCO:B0011244 name: CLAP1_HUMAN-Phosphoserine545 def: "Protein CLAP1_HUMAN with the residue 545 substituted with Phosphoserine" [UniProtKB:Q7Z460] comment: By similarity xref: UniProtKB:Q7Z460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001933 ! CLAP1_HUMAN [Term] id: CCO:B0011245 name: CLAP1_HUMAN-Phosphoserine559 def: "Protein CLAP1_HUMAN with the residue 559 substituted with Phosphoserine" [UniProtKB:Q7Z460] xref: UniProtKB:Q7Z460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001933 ! CLAP1_HUMAN [Term] id: CCO:B0011246 name: CLAP1_HUMAN-Phosphoserine568 def: "Protein CLAP1_HUMAN with the residue 568 substituted with Phosphoserine" [UniProtKB:Q7Z460] xref: UniProtKB:Q7Z460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001933 ! CLAP1_HUMAN [Term] id: CCO:B0011247 name: CLAP1_HUMAN-Phosphoserine598 def: "Protein CLAP1_HUMAN with the residue 598 substituted with Phosphoserine" [UniProtKB:Q7Z460] comment: By similarity xref: UniProtKB:Q7Z460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001933 ! CLAP1_HUMAN [Term] id: CCO:B0011248 name: CLAP1_HUMAN-Phosphoserine600 def: "Protein CLAP1_HUMAN with the residue 600 substituted with Phosphoserine" [UniProtKB:Q7Z460] comment: By similarity xref: UniProtKB:Q7Z460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001933 ! CLAP1_HUMAN [Term] id: CCO:B0011249 name: CLAP1_HUMAN-Phosphoserine609 def: "Protein CLAP1_HUMAN with the residue 609 substituted with Phosphoserine" [UniProtKB:Q7Z460] xref: UniProtKB:Q7Z460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001933 ! CLAP1_HUMAN [Term] id: CCO:B0011250 name: CLAP1_HUMAN-Phosphoserine1196 def: "Protein CLAP1_HUMAN with the residue 1196 substituted with Phosphoserine" [UniProtKB:Q7Z460] xref: UniProtKB:Q7Z460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001933 ! CLAP1_HUMAN [Term] id: CCO:B0011251 name: CLAP1_HUMAN-Phosphoserine1223 def: "Protein CLAP1_HUMAN with the residue 1223 substituted with Phosphoserine" [UniProtKB:Q7Z460] xref: UniProtKB:Q7Z460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001933 ! CLAP1_HUMAN [Term] id: CCO:B0011252 name: CLAP2_HUMAN-Phosphoserine326 def: "Protein CLAP2_HUMAN with the residue 326 substituted with Phosphoserine" [UniProtKB:O75122] xref: UniProtKB:O75122 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001422 ! CLAP2_HUMAN [Term] id: CCO:B0011253 name: CLAP2_HUMAN-Phosphoserine327 def: "Protein CLAP2_HUMAN with the residue 327 substituted with Phosphoserine" [UniProtKB:O75122] xref: UniProtKB:O75122 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001422 ! CLAP2_HUMAN [Term] id: CCO:B0011254 name: CLAP2_HUMAN-Phosphoserine330 def: "Protein CLAP2_HUMAN with the residue 330 substituted with Phosphoserine" [UniProtKB:O75122] xref: UniProtKB:O75122 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001422 ! CLAP2_HUMAN [Term] id: CCO:B0011255 name: CLAP2_HUMAN-Phosphoserine507 def: "Protein CLAP2_HUMAN with the residue 507 substituted with Phosphoserine" [UniProtKB:O75122] comment: By similarity xref: UniProtKB:O75122 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001422 ! CLAP2_HUMAN [Term] id: CCO:B0011256 name: CLAP2_HUMAN-Phosphoserine525 def: "Protein CLAP2_HUMAN with the residue 525 substituted with Phosphoserine" [UniProtKB:O75122] xref: UniProtKB:O75122 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001422 ! CLAP2_HUMAN [Term] id: CCO:B0011257 name: CLAP2_HUMAN-Phosphoserine529 def: "Protein CLAP2_HUMAN with the residue 529 substituted with Phosphoserine" [UniProtKB:O75122] xref: UniProtKB:O75122 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001422 ! CLAP2_HUMAN [Term] id: CCO:B0011258 name: CLAP2_HUMAN-Phosphoserine596 def: "Protein CLAP2_HUMAN with the residue 596 substituted with Phosphoserine" [UniProtKB:O75122] comment: By similarity xref: UniProtKB:O75122 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001422 ! CLAP2_HUMAN [Term] id: CCO:B0011259 name: CLAP2_HUMAN-Phosphoserine994 def: "Protein CLAP2_HUMAN with the residue 994 substituted with Phosphoserine" [UniProtKB:O75122] xref: UniProtKB:O75122 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001422 ! CLAP2_HUMAN [Term] id: CCO:B0011260 name: CLH2_HUMAN-Phosphothreonine103 def: "Protein CLH2_HUMAN with the residue 103 substituted with Phosphothreonine" [UniProtKB:P53675] xref: UniProtKB:P53675 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005460 ! CLH2_HUMAN [Term] id: CCO:B0011261 name: CLIP1_HUMAN-Phosphothreonine182 def: "Protein CLIP1_HUMAN with the residue 182 substituted with Phosphothreonine" [UniProtKB:P30622] xref: UniProtKB:P30622 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001580 ! CLIP1_HUMAN [Term] id: CCO:B0011262 name: CLIP1_HUMAN-Phosphoserine195 def: "Protein CLIP1_HUMAN with the residue 195 substituted with Phosphoserine" [UniProtKB:P30622] xref: UniProtKB:P30622 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001580 ! CLIP1_HUMAN [Term] id: CCO:B0011263 name: CLIP1_HUMAN-Phosphoserine200 def: "Protein CLIP1_HUMAN with the residue 200 substituted with Phosphoserine" [UniProtKB:P30622] xref: UniProtKB:P30622 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001679 ! microtubule binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0005714 ! protein homodimerization activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000103 ! kinetochore relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000351 ! endosome relationship: located_in CCO:C0000421 ! cytoskeleton relationship: located_in CCO:C0000434 ! microtubule relationship: located_in CCO:C0000440 ! intermediate filament relationship: located_in CCO:C0000754 ! microtubule cytoskeleton relationship: transformation_of CCO:B0001580 ! CLIP1_HUMAN [Term] id: CCO:B0011264 name: CLIP1_HUMAN-Phosphoserine204 def: "Protein CLIP1_HUMAN with the residue 204 substituted with Phosphoserine" [UniProtKB:P30622] xref: UniProtKB:P30622 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001580 ! CLIP1_HUMAN [Term] id: CCO:B0011267 name: CLSPN_HUMAN-Phosphoserine65 def: "Protein CLSPN_HUMAN with the residue 65 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011268 name: CLSPN_HUMAN-Phosphoserine67 def: "Protein CLSPN_HUMAN with the residue 67 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011269 name: CLSPN_HUMAN-Phosphoserine75 def: "Protein CLSPN_HUMAN with the residue 75 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011270 name: CLSPN_HUMAN-Phosphoserine762 def: "Protein CLSPN_HUMAN with the residue 762 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011271 name: CLSPN_HUMAN-Phosphoserine764 def: "Protein CLSPN_HUMAN with the residue 764 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011272 name: CLSPN_HUMAN-Phosphoserine833 def: "Protein CLSPN_HUMAN with the residue 833 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011273 name: CLSPN_HUMAN-Phosphoserine839 def: "Protein CLSPN_HUMAN with the residue 839 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011274 name: CLSPN_HUMAN-Phosphoserine846 def: "Protein CLSPN_HUMAN with the residue 846 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011275 name: CLSPN_HUMAN-Phosphoserine950 def: "Protein CLSPN_HUMAN with the residue 950 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011276 name: CLSPN_HUMAN-Phosphothreonine1287 def: "Protein CLSPN_HUMAN with the residue 1287 substituted with Phosphothreonine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011277 name: CLSPN_HUMAN-Phosphoserine1289 def: "Protein CLSPN_HUMAN with the residue 1289 substituted with Phosphoserine" [UniProtKB:Q9HAW4] xref: UniProtKB:Q9HAW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002142 ! CLSPN_HUMAN [Term] id: CCO:B0011280 name: CND1_HUMAN-Phosphothreonine103 def: "Protein CND1_HUMAN with the residue 103 substituted with Phosphothreonine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011281 name: CND1_HUMAN-Phosphothreonine577 def: "Protein CND1_HUMAN with the residue 577 substituted with Phosphothreonine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011282 name: CND1_HUMAN-Phosphoserine585 def: "Protein CND1_HUMAN with the residue 585 substituted with Phosphoserine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011283 name: CND1_HUMAN-Phosphoserine1310 def: "Protein CND1_HUMAN with the residue 1310 substituted with Phosphoserine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011284 name: CND1_HUMAN-Phosphoserine1330 def: "Protein CND1_HUMAN with the residue 1330 substituted with Phosphoserine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011285 name: CND1_HUMAN-Phosphothreonine1331 def: "Protein CND1_HUMAN with the residue 1331 substituted with Phosphothreonine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011286 name: CND1_HUMAN-Phosphoserine1333 def: "Protein CND1_HUMAN with the residue 1333 substituted with Phosphoserine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011287 name: CND1_HUMAN-Phosphothreonine1339 def: "Protein CND1_HUMAN with the residue 1339 substituted with Phosphothreonine" [UniProtKB:Q15021] comment: by CDC2; By similarity xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011288 name: CND1_HUMAN-Phosphoserine1366 def: "Protein CND1_HUMAN with the residue 1366 substituted with Phosphoserine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011289 name: CND1_HUMAN-Phosphoserine1367 def: "Protein CND1_HUMAN with the residue 1367 substituted with Phosphoserine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011290 name: CND1_HUMAN-Phosphoserine1370 def: "Protein CND1_HUMAN with the residue 1370 substituted with Phosphoserine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011291 name: CND1_HUMAN-Phosphoserine1371 def: "Protein CND1_HUMAN with the residue 1371 substituted with Phosphoserine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011292 name: CND1_HUMAN-Phosphoserine1376 def: "Protein CND1_HUMAN with the residue 1376 substituted with Phosphoserine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011293 name: CND1_HUMAN-Phosphothreonine1384 def: "Protein CND1_HUMAN with the residue 1384 substituted with Phosphothreonine" [UniProtKB:Q15021] comment: by CDC2; By similarity xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011294 name: CND1_HUMAN-Phosphothreonine1388 def: "Protein CND1_HUMAN with the residue 1388 substituted with Phosphothreonine" [UniProtKB:Q15021] xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011295 name: CND1_HUMAN-Phosphothreonine1389 def: "Protein CND1_HUMAN with the residue 1389 substituted with Phosphothreonine" [UniProtKB:Q15021] comment: by CDC2; By similarity xref: UniProtKB:Q15021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001801 ! CND1_HUMAN [Term] id: CCO:B0011296 name: CND2_HUMAN-Phosphothreonine49 def: "Protein CND2_HUMAN with the residue 49 substituted with Phosphothreonine" [UniProtKB:Q15003] xref: UniProtKB:Q15003 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001797 ! CND2_HUMAN [Term] id: CCO:B0011297 name: CND2_HUMAN-Phosphoserine78 def: "Protein CND2_HUMAN with the residue 78 substituted with Phosphoserine" [UniProtKB:Q15003] xref: UniProtKB:Q15003 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001797 ! CND2_HUMAN [Term] id: CCO:B0011298 name: CND2_HUMAN-Phosphoserine81 def: "Protein CND2_HUMAN with the residue 81 substituted with Phosphoserine" [UniProtKB:Q15003] xref: UniProtKB:Q15003 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001797 ! CND2_HUMAN [Term] id: CCO:B0011299 name: CND2_HUMAN-Phosphoserine92 def: "Protein CND2_HUMAN with the residue 92 substituted with Phosphoserine" [UniProtKB:Q15003] xref: UniProtKB:Q15003 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001797 ! CND2_HUMAN [Term] id: CCO:B0011300 name: CND2_HUMAN-Phosphoserine96 def: "Protein CND2_HUMAN with the residue 96 substituted with Phosphoserine" [UniProtKB:Q15003] xref: UniProtKB:Q15003 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001797 ! CND2_HUMAN [Term] id: CCO:B0011301 name: CND2_HUMAN-Phosphoserine201 def: "Protein CND2_HUMAN with the residue 201 substituted with Phosphoserine" [UniProtKB:Q15003] xref: UniProtKB:Q15003 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001797 ! CND2_HUMAN [Term] id: CCO:B0011302 name: CND2_HUMAN-Phosphoserine335 def: "Protein CND2_HUMAN with the residue 335 substituted with Phosphoserine" [UniProtKB:Q15003] xref: UniProtKB:Q15003 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001797 ! CND2_HUMAN [Term] id: CCO:B0011303 name: CND2_HUMAN-Phosphothreonine605 def: "Protein CND2_HUMAN with the residue 605 substituted with Phosphothreonine" [UniProtKB:Q15003] xref: UniProtKB:Q15003 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001797 ! CND2_HUMAN [Term] id: CCO:B0011304 name: CND3_HUMAN-Phosphoserine390 def: "Protein CND3_HUMAN with the residue 390 substituted with Phosphoserine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0011305 name: CND3_HUMAN-Phosphothreonine463 def: "Protein CND3_HUMAN with the residue 463 substituted with Phosphothreonine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0011306 name: CND3_HUMAN-Phosphoserine467 def: "Protein CND3_HUMAN with the residue 467 substituted with Phosphoserine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0011307 name: CND3_HUMAN-Phosphoserine674 def: "Protein CND3_HUMAN with the residue 674 substituted with Phosphoserine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0011308 name: CND3_HUMAN-Phosphoserine944 def: "Protein CND3_HUMAN with the residue 944 substituted with Phosphoserine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0011309 name: CND3_HUMAN-Phosphoserine959 def: "Protein CND3_HUMAN with the residue 959 substituted with Phosphoserine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0011310 name: CND3_HUMAN-Phosphoserine973 def: "Protein CND3_HUMAN with the residue 973 substituted with Phosphoserine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0011311 name: CND3_HUMAN-Phosphoserine975 def: "Protein CND3_HUMAN with the residue 975 substituted with Phosphoserine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0011312 name: CND3_HUMAN-Phosphoserine1015 def: "Protein CND3_HUMAN with the residue 1015 substituted with Phosphoserine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0011313 name: CNDD3_HUMAN-Phosphoserine531 def: "Protein CNDD3_HUMAN with the residue 531 substituted with Phosphoserine" [UniProtKB:P42695] xref: UniProtKB:P42695 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001614 ! CNDD3_HUMAN [Term] id: CCO:B0011314 name: CNDD3_HUMAN-Phosphotyrosine972 def: "Protein CNDD3_HUMAN with the residue 972 substituted with Phosphotyrosine" [UniProtKB:P42695] xref: UniProtKB:P42695 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001614 ! CNDD3_HUMAN [Term] id: CCO:B0011315 name: CNDD3_HUMAN-Phosphoserine1384 def: "Protein CNDD3_HUMAN with the residue 1384 substituted with Phosphoserine" [UniProtKB:P42695] xref: UniProtKB:P42695 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001614 ! CNDD3_HUMAN [Term] id: CCO:B0011316 name: CNDD3_HUMAN-Phosphoserine1393 def: "Protein CNDD3_HUMAN with the residue 1393 substituted with Phosphoserine" [UniProtKB:P42695] xref: UniProtKB:P42695 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001614 ! CNDD3_HUMAN [Term] id: CCO:B0011317 name: CNDG2_HUMAN-Phosphothreonine805 def: "Protein CNDG2_HUMAN with the residue 805 substituted with Phosphothreonine" [UniProtKB:Q86XI2] xref: UniProtKB:Q86XI2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001943 ! CNDG2_HUMAN [Term] id: CCO:B0011318 name: CNDG2_HUMAN-Phosphothreonine1119 def: "Protein CNDG2_HUMAN with the residue 1119 substituted with Phosphothreonine" [UniProtKB:Q86XI2] xref: UniProtKB:Q86XI2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001943 ! CNDG2_HUMAN [Term] id: CCO:B0011319 name: CNTRB_HUMAN-Phosphoserine781 def: "Protein CNTRB_HUMAN with the residue 781 substituted with Phosphoserine" [UniProtKB:Q8N137] xref: UniProtKB:Q8N137 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000384 ! centriole relationship: transformation_of CCO:B0001961 ! CNTRB_HUMAN [Term] id: CCO:B0011338 name: CPNS1_HUMAN-N-acetylmethionine1 def: "Protein CPNS1_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P04632] xref: UniProtKB:P04632 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006088 ! CPNS1_HUMAN [Term] id: CCO:B0011339 name: CR025_HUMAN-Phosphoserine39 def: "Protein CR025_HUMAN with the residue 39 substituted with Phosphoserine" [UniProtKB:Q96B23] xref: UniProtKB:Q96B23 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005186 ! CR025_HUMAN [Term] id: CCO:B0011340 name: CR025_HUMAN-Phosphoserine66 def: "Protein CR025_HUMAN with the residue 66 substituted with Phosphoserine" [UniProtKB:Q96B23] xref: UniProtKB:Q96B23 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005186 ! CR025_HUMAN [Term] id: CCO:B0011341 name: CR025_HUMAN-Phosphoserine69 def: "Protein CR025_HUMAN with the residue 69 substituted with Phosphoserine" [UniProtKB:Q96B23] xref: UniProtKB:Q96B23 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005186 ! CR025_HUMAN [Term] id: CCO:B0011342 name: CR025_HUMAN-Phosphoserine327 def: "Protein CR025_HUMAN with the residue 327 substituted with Phosphoserine" [UniProtKB:Q96B23] xref: UniProtKB:Q96B23 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005186 ! CR025_HUMAN [Term] id: CCO:B0011343 name: CR025_HUMAN-Phosphoserine328 def: "Protein CR025_HUMAN with the residue 328 substituted with Phosphoserine" [UniProtKB:Q96B23] xref: UniProtKB:Q96B23 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005186 ! CR025_HUMAN [Term] id: CCO:B0011344 name: CR025_HUMAN-Phosphoserine330 def: "Protein CR025_HUMAN with the residue 330 substituted with Phosphoserine" [UniProtKB:Q96B23] xref: UniProtKB:Q96B23 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005186 ! CR025_HUMAN [Term] id: CCO:B0011345 name: CREB1_HUMAN-Phosphoserine111 def: "Protein CREB1_HUMAN with the residue 111 substituted with Phosphoserine" [UniProtKB:P16220] xref: UniProtKB:P16220 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005681 ! CREB1_HUMAN [Term] id: CCO:B0011346 name: CREB1_HUMAN-Phosphothreonine119 def: "Protein CREB1_HUMAN with the residue 119 substituted with Phosphothreonine" [UniProtKB:P16220] xref: UniProtKB:P16220 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005681 ! CREB1_HUMAN [Term] id: CCO:B0011347 name: CREB1_HUMAN-Phosphoserine133 def: "Protein CREB1_HUMAN with the residue 133 substituted with Phosphoserine" [UniProtKB:P16220] comment: by CaMK1, CaMK2 and CaMK4; xref: UniProtKB:P16220 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005681 ! CREB1_HUMAN [Term] id: CCO:B0011348 name: CREB1_HUMAN-Phosphoserine142 def: "Protein CREB1_HUMAN with the residue 142 substituted with Phosphoserine" [UniProtKB:P16220] comment: by CaMK2; By similarity xref: UniProtKB:P16220 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005681 ! CREB1_HUMAN [Term] id: CCO:B0011349 name: CROCC_HUMAN-Phosphoserine1619 def: "Protein CROCC_HUMAN with the residue 1619 substituted with Phosphoserine" [UniProtKB:Q5TZA2] xref: UniProtKB:Q5TZA2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001895 ! CROCC_HUMAN [Term] id: CCO:B0011357 name: CSN1_HUMAN-Phosphoserine448 def: "Protein CSN1_HUMAN with the residue 448 substituted with Phosphoserine" [UniProtKB:Q13098] xref: UniProtKB:Q13098 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001740 ! CSN1_HUMAN [Term] id: CCO:B0011358 name: CSN1_HUMAN-Phosphoserine454 def: "Protein CSN1_HUMAN with the residue 454 substituted with Phosphoserine" [UniProtKB:Q13098] xref: UniProtKB:Q13098 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001740 ! CSN1_HUMAN [Term] id: CCO:B0011359 name: CSN1_HUMAN-Phosphothreonine459 def: "Protein CSN1_HUMAN with the residue 459 substituted with Phosphothreonine" [UniProtKB:Q13098] xref: UniProtKB:Q13098 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001740 ! CSN1_HUMAN [Term] id: CCO:B0011360 name: CSN1_HUMAN-Phosphoserine463 def: "Protein CSN1_HUMAN with the residue 463 substituted with Phosphoserine" [UniProtKB:Q13098] xref: UniProtKB:Q13098 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001740 ! CSN1_HUMAN [Term] id: CCO:B0011361 name: CSN1_HUMAN-Phosphoserine468 def: "Protein CSN1_HUMAN with the residue 468 substituted with Phosphoserine" [UniProtKB:Q13098] xref: UniProtKB:Q13098 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001740 ! CSN1_HUMAN [Term] id: CCO:B0011362 name: CSN5_HUMAN-N-acetylalanine2 def: "Protein CSN5_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q92905] xref: UniProtKB:Q92905 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002025 ! CSN5_HUMAN [Term] id: CCO:B0011364 name: CTCF_HUMAN-Phosphoserine609 def: "Protein CTCF_HUMAN with the residue 609 substituted with Phosphoserine" [UniProtKB:P49711] xref: UniProtKB:P49711 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001630 ! CTCF_HUMAN [Term] id: CCO:B0011365 name: CTCF_HUMAN-Phosphoserine610 def: "Protein CTCF_HUMAN with the residue 610 substituted with Phosphoserine" [UniProtKB:P49711] xref: UniProtKB:P49711 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001630 ! CTCF_HUMAN [Term] id: CCO:B0011366 name: CTCF_HUMAN-Phosphoserine612 def: "Protein CTCF_HUMAN with the residue 612 substituted with Phosphoserine" [UniProtKB:P49711] xref: UniProtKB:P49711 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001630 ! CTCF_HUMAN [Term] id: CCO:B0011367 name: CTNA1_HUMAN-Phosphoserine641 def: "Protein CTNA1_HUMAN with the residue 641 substituted with Phosphoserine" [UniProtKB:P35221] xref: UniProtKB:P35221 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005824 ! CTNA1_HUMAN [Term] id: CCO:B0011368 name: CTNA1_HUMAN-Phosphoserine652 def: "Protein CTNA1_HUMAN with the residue 652 substituted with Phosphoserine" [UniProtKB:P35221] xref: UniProtKB:P35221 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005824 ! CTNA1_HUMAN [Term] id: CCO:B0011369 name: CTNA1_HUMAN-Phosphothreonine654 def: "Protein CTNA1_HUMAN with the residue 654 substituted with Phosphothreonine" [UniProtKB:P35221] comment: By similarity xref: UniProtKB:P35221 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005824 ! CTNA1_HUMAN [Term] id: CCO:B0011370 name: CTNA1_HUMAN-Phosphoserine655 def: "Protein CTNA1_HUMAN with the residue 655 substituted with Phosphoserine" [UniProtKB:P35221] comment: By similarity xref: UniProtKB:P35221 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005824 ! CTNA1_HUMAN [Term] id: CCO:B0011371 name: CTNA1_HUMAN-Phosphothreonine658 def: "Protein CTNA1_HUMAN with the residue 658 substituted with Phosphothreonine" [UniProtKB:P35221] xref: UniProtKB:P35221 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005824 ! CTNA1_HUMAN [Term] id: CCO:B0011372 name: CTNB1_HUMAN-Phosphoserine23 def: "Protein CTNB1_HUMAN with the residue 23 substituted with Phosphoserine" [UniProtKB:P35222] comment: by GSK3-beta; xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011373 name: CTNB1_HUMAN-Phosphoserine29 def: "Protein CTNB1_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:P35222] comment: by GSK3-beta; xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011374 name: CTNB1_HUMAN-Phosphoserine33 def: "Protein CTNB1_HUMAN with the residue 33 substituted with Phosphoserine" [UniProtKB:P35222] comment: by GSK3-beta; xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011375 name: CTNB1_HUMAN-Phosphoserine37 def: "Protein CTNB1_HUMAN with the residue 37 substituted with Phosphoserine" [UniProtKB:P35222] comment: by GSK3-beta; xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011376 name: CTNB1_HUMAN-Phosphothreonine41 def: "Protein CTNB1_HUMAN with the residue 41 substituted with Phosphothreonine" [UniProtKB:P35222] comment: by GSK3-beta; xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011377 name: CTNB1_HUMAN-Phosphoserine45 def: "Protein CTNB1_HUMAN with the residue 45 substituted with Phosphoserine" [UniProtKB:P35222] xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011378 name: CTNB1_HUMAN-Phosphotyrosine86 def: "Protein CTNB1_HUMAN with the residue 86 substituted with Phosphotyrosine" [UniProtKB:P35222] comment: by CSK; xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011379 name: CTNB1_HUMAN-Phosphoserine191 def: "Protein CTNB1_HUMAN with the residue 191 substituted with Phosphoserine" [UniProtKB:P35222] comment: By similarity xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011380 name: CTNB1_HUMAN-Phosphothreonine551 def: "Protein CTNB1_HUMAN with the residue 551 substituted with Phosphothreonine" [UniProtKB:P35222] comment: By similarity xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011381 name: CTNB1_HUMAN-Phosphoserine552 def: "Protein CTNB1_HUMAN with the residue 552 substituted with Phosphoserine" [UniProtKB:P35222] xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011382 name: CTNB1_HUMAN-Phosphothreonine556 def: "Protein CTNB1_HUMAN with the residue 556 substituted with Phosphothreonine" [UniProtKB:P35222] comment: By similarity xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011383 name: CTNB1_HUMAN-Phosphotyrosine654 def: "Protein CTNB1_HUMAN with the residue 654 substituted with Phosphotyrosine" [UniProtKB:P35222] comment: by CSK; xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011384 name: CTNB1_HUMAN-Phosphoserine675 def: "Protein CTNB1_HUMAN with the residue 675 substituted with Phosphoserine" [UniProtKB:P35222] xref: UniProtKB:P35222 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:B0011385 name: CTND1_HUMAN-Phosphoserine47 def: "Protein CTND1_HUMAN with the residue 47 substituted with Phosphoserine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011386 name: CTND1_HUMAN-Phosphotyrosine96 def: "Protein CTND1_HUMAN with the residue 96 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011387 name: CTND1_HUMAN-Phosphotyrosine174 def: "Protein CTND1_HUMAN with the residue 174 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011388 name: CTND1_HUMAN-Phosphotyrosine217 def: "Protein CTND1_HUMAN with the residue 217 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011389 name: CTND1_HUMAN-Phosphotyrosine228 def: "Protein CTND1_HUMAN with the residue 228 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011390 name: CTND1_HUMAN-Phosphotyrosine257 def: "Protein CTND1_HUMAN with the residue 257 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011391 name: CTND1_HUMAN-Phosphoserine268 def: "Protein CTND1_HUMAN with the residue 268 substituted with Phosphoserine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011392 name: CTND1_HUMAN-Phosphoserine269 def: "Protein CTND1_HUMAN with the residue 269 substituted with Phosphoserine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011393 name: CTND1_HUMAN-Phosphotyrosine280 def: "Protein CTND1_HUMAN with the residue 280 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011394 name: CTND1_HUMAN-Phosphoserine288 def: "Protein CTND1_HUMAN with the residue 288 substituted with Phosphoserine" [UniProtKB:O60716] comment: By similarity xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011395 name: CTND1_HUMAN-Phosphotyrosine291 def: "Protein CTND1_HUMAN with the residue 291 substituted with Phosphotyrosine" [UniProtKB:O60716] comment: By similarity xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011396 name: CTND1_HUMAN-Phosphotyrosine302 def: "Protein CTND1_HUMAN with the residue 302 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011397 name: CTND1_HUMAN-Phosphothreonine310 def: "Protein CTND1_HUMAN with the residue 310 substituted with Phosphothreonine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011398 name: CTND1_HUMAN-Phosphoserine320 def: "Protein CTND1_HUMAN with the residue 320 substituted with Phosphoserine" [UniProtKB:O60716] comment: By similarity xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011399 name: CTND1_HUMAN-Phosphotyrosine321 def: "Protein CTND1_HUMAN with the residue 321 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011400 name: CTND1_HUMAN-Phosphotyrosine334 def: "Protein CTND1_HUMAN with the residue 334 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011401 name: CTND1_HUMAN-Phosphoserine349 def: "Protein CTND1_HUMAN with the residue 349 substituted with Phosphoserine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011402 name: CTND1_HUMAN-Phosphoserine352 def: "Protein CTND1_HUMAN with the residue 352 substituted with Phosphoserine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011403 name: CTND1_HUMAN-Phosphoserine859 def: "Protein CTND1_HUMAN with the residue 859 substituted with Phosphoserine" [UniProtKB:O60716] comment: By similarity xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011404 name: CTND1_HUMAN-Phosphotyrosine865 def: "Protein CTND1_HUMAN with the residue 865 substituted with Phosphotyrosine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011405 name: CTND1_HUMAN-Phosphothreonine916 def: "Protein CTND1_HUMAN with the residue 916 substituted with Phosphothreonine" [UniProtKB:O60716] xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0011406 name: CTRO_HUMAN-Phosphoserine440 def: "Protein CTRO_HUMAN with the residue 440 substituted with Phosphoserine" [UniProtKB:O14578] xref: UniProtKB:O14578 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001388 ! small GTPase regulator activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0004248 ! diacylglycerol binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001356 ! CTRO_HUMAN [Term] id: CCO:B0011407 name: CTRO_HUMAN-Phosphoserine480 def: "Protein CTRO_HUMAN with the residue 480 substituted with Phosphoserine" [UniProtKB:O14578] comment: By similarity xref: UniProtKB:O14578 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001356 ! CTRO_HUMAN [Term] id: CCO:B0011408 name: CTRO_HUMAN-Phosphoserine1582 def: "Protein CTRO_HUMAN with the residue 1582 substituted with Phosphoserine" [UniProtKB:O14578] comment: By similarity xref: UniProtKB:O14578 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001356 ! CTRO_HUMAN [Term] id: CCO:B0011409 name: CTRO_HUMAN-Phosphoserine1971 def: "Protein CTRO_HUMAN with the residue 1971 substituted with Phosphoserine" [UniProtKB:O14578] xref: UniProtKB:O14578 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001356 ! CTRO_HUMAN [Term] id: CCO:B0011410 name: CTRO_HUMAN-Phosphoserine1993 def: "Protein CTRO_HUMAN with the residue 1993 substituted with Phosphoserine" [UniProtKB:O14578] xref: UniProtKB:O14578 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001356 ! CTRO_HUMAN [Term] id: CCO:B0011411 name: CUL2_HUMAN-Phosphotyrosine394 def: "Protein CUL2_HUMAN with the residue 394 substituted with Phosphotyrosine" [UniProtKB:Q13617] comment: By similarity xref: UniProtKB:Q13617 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001760 ! CUL2_HUMAN [Term] id: CCO:B0011412 name: CUL3_HUMAN-Phosphotyrosine58 def: "Protein CUL3_HUMAN with the residue 58 substituted with Phosphotyrosine" [UniProtKB:Q13618] xref: UniProtKB:Q13618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001761 ! CUL3_HUMAN [Term] id: CCO:B0011413 name: CUL3_HUMAN-Phosphoserine737 def: "Protein CUL3_HUMAN with the residue 737 substituted with Phosphoserine" [UniProtKB:Q13618] xref: UniProtKB:Q13618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001761 ! CUL3_HUMAN [Term] id: CCO:B0011419 name: CYLD_HUMAN-Phosphoserine399 def: "Protein CYLD_HUMAN with the residue 399 substituted with Phosphoserine" [UniProtKB:Q9NQC7] xref: UniProtKB:Q9NQC7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002153 ! CYLD_HUMAN [Term] id: CCO:B0011420 name: CYTSA_HUMAN-Phosphoserine54 def: "Protein CYTSA_HUMAN with the residue 54 substituted with Phosphoserine" [UniProtKB:Q69YQ0] comment: By similarity xref: UniProtKB:Q69YQ0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001906 ! CYTSA_HUMAN [Term] id: CCO:B0011421 name: CYTSA_HUMAN-Phosphoserine220 def: "Protein CYTSA_HUMAN with the residue 220 substituted with Phosphoserine" [UniProtKB:Q69YQ0] xref: UniProtKB:Q69YQ0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001906 ! CYTSA_HUMAN [Term] id: CCO:B0011422 name: DAB2P_HUMAN-Phosphoserine702 def: "Protein DAB2P_HUMAN with the residue 702 substituted with Phosphoserine" [UniProtKB:Q5VWQ8] xref: UniProtKB:Q5VWQ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001899 ! DAB2P_HUMAN [Term] id: CCO:B0011423 name: DACH1_HUMAN-Phosphothreonine578 def: "Protein DACH1_HUMAN with the residue 578 substituted with Phosphothreonine" [UniProtKB:Q9UI36] xref: UniProtKB:Q9UI36 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005195 ! DACH1_HUMAN [Term] id: CCO:B0011424 name: DACH1_HUMAN-Phosphoserine581 def: "Protein DACH1_HUMAN with the residue 581 substituted with Phosphoserine" [UniProtKB:Q9UI36] xref: UniProtKB:Q9UI36 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005195 ! DACH1_HUMAN [Term] id: CCO:B0011425 name: DACH1_HUMAN-Phosphothreonine582 def: "Protein DACH1_HUMAN with the residue 582 substituted with Phosphothreonine" [UniProtKB:Q9UI36] xref: UniProtKB:Q9UI36 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005195 ! DACH1_HUMAN [Term] id: CCO:B0011426 name: DACH1_HUMAN-Phosphothreonine584 def: "Protein DACH1_HUMAN with the residue 584 substituted with Phosphothreonine" [UniProtKB:Q9UI36] xref: UniProtKB:Q9UI36 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005195 ! DACH1_HUMAN [Term] id: CCO:B0011427 name: DAPK1_HUMAN-Phosphoserine308 def: "Protein DAPK1_HUMAN with the residue 308 substituted with Phosphoserine" [UniProtKB:P53355] comment: by autocatalysis; xref: UniProtKB:P53355 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005482 ! DAPK1_HUMAN [Term] id: CCO:B0011428 name: DAXX_HUMAN-Phosphoserine213 def: "Protein DAXX_HUMAN with the residue 213 substituted with Phosphoserine" [UniProtKB:Q9UER7] comment: By similarity xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011429 name: DAXX_HUMAN-Phosphothreonine459 def: "Protein DAXX_HUMAN with the residue 459 substituted with Phosphothreonine" [UniProtKB:Q9UER7] comment: By similarity xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011430 name: DAXX_HUMAN-Phosphoserine495 def: "Protein DAXX_HUMAN with the residue 495 substituted with Phosphoserine" [UniProtKB:Q9UER7] comment: By similarity xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011431 name: DAXX_HUMAN-Phosphotyrosine648 def: "Protein DAXX_HUMAN with the residue 648 substituted with Phosphotyrosine" [UniProtKB:Q9UER7] xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011432 name: DAXX_HUMAN-Phosphoserine668 def: "Protein DAXX_HUMAN with the residue 668 substituted with Phosphoserine" [UniProtKB:Q9UER7] comment: Probable xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011433 name: DAXX_HUMAN-Phosphoserine671 def: "Protein DAXX_HUMAN with the residue 671 substituted with Phosphoserine" [UniProtKB:Q9UER7] xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011434 name: DAXX_HUMAN-Phosphothreonine709 def: "Protein DAXX_HUMAN with the residue 709 substituted with Phosphothreonine" [UniProtKB:Q9UER7] xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011435 name: DAXX_HUMAN-Phosphoserine712 def: "Protein DAXX_HUMAN with the residue 712 substituted with Phosphoserine" [UniProtKB:Q9UER7] xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011436 name: DAXX_HUMAN-Phosphoserine737 def: "Protein DAXX_HUMAN with the residue 737 substituted with Phosphoserine" [UniProtKB:Q9UER7] xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011437 name: DAXX_HUMAN-Phosphoserine739 def: "Protein DAXX_HUMAN with the residue 739 substituted with Phosphoserine" [UniProtKB:Q9UER7] xref: UniProtKB:Q9UER7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:B0011441 name: DC1I1_HUMAN-Phosphoserine635 def: "Protein DC1I1_HUMAN with the residue 635 substituted with Phosphoserine" [UniProtKB:O14576] comment: By similarity xref: UniProtKB:O14576 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005648 ! DC1I1_HUMAN [Term] id: CCO:B0011442 name: DCP1A_HUMAN-Phosphoserine353 def: "Protein DCP1A_HUMAN with the residue 353 substituted with Phosphoserine" [UniProtKB:Q9NPI6] xref: UniProtKB:Q9NPI6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005432 ! DCP1A_HUMAN [Term] id: CCO:B0011443 name: DCP1A_HUMAN-Phosphoserine523 def: "Protein DCP1A_HUMAN with the residue 523 substituted with Phosphoserine" [UniProtKB:Q9NPI6] xref: UniProtKB:Q9NPI6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005432 ! DCP1A_HUMAN [Term] id: CCO:B0011444 name: DCP1A_HUMAN-Phosphoserine525 def: "Protein DCP1A_HUMAN with the residue 525 substituted with Phosphoserine" [UniProtKB:Q9NPI6] xref: UniProtKB:Q9NPI6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005432 ! DCP1A_HUMAN [Term] id: CCO:B0011445 name: DCP2_HUMAN-Phosphoserine246 def: "Protein DCP2_HUMAN with the residue 246 substituted with Phosphoserine" [UniProtKB:Q8IU60] xref: UniProtKB:Q8IU60 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005433 ! DCP2_HUMAN [Term] id: CCO:B0011446 name: DCP2_HUMAN-Phosphoserine247 def: "Protein DCP2_HUMAN with the residue 247 substituted with Phosphoserine" [UniProtKB:Q8IU60] xref: UniProtKB:Q8IU60 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005433 ! DCP2_HUMAN [Term] id: CCO:B0011447 name: DCP2_HUMAN-Phosphoserine249 def: "Protein DCP2_HUMAN with the residue 249 substituted with Phosphoserine" [UniProtKB:Q8IU60] xref: UniProtKB:Q8IU60 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005433 ! DCP2_HUMAN [Term] id: CCO:B0011448 name: DCP2_HUMAN-Phosphoserine276 def: "Protein DCP2_HUMAN with the residue 276 substituted with Phosphoserine" [UniProtKB:Q8IU60] xref: UniProtKB:Q8IU60 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005433 ! DCP2_HUMAN [Term] id: CCO:B0011449 name: DCP2_HUMAN-Phosphoserine284 def: "Protein DCP2_HUMAN with the residue 284 substituted with Phosphoserine" [UniProtKB:Q8IU60] xref: UniProtKB:Q8IU60 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005433 ! DCP2_HUMAN [Term] id: CCO:B0011450 name: DCP2_HUMAN-Phosphoserine347 def: "Protein DCP2_HUMAN with the residue 347 substituted with Phosphoserine" [UniProtKB:Q8IU60] xref: UniProtKB:Q8IU60 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005433 ! DCP2_HUMAN [Term] id: CCO:B0011451 name: DCR1A_HUMAN-Phosphoserine590 def: "Protein DCR1A_HUMAN with the residue 590 substituted with Phosphoserine" [UniProtKB:Q6PJP8] comment: By similarity xref: UniProtKB:Q6PJP8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001916 ! DCR1A_HUMAN [Term] id: CCO:B0011452 name: DCTN1_HUMAN-Phosphoserine541 def: "Protein DCTN1_HUMAN with the residue 541 substituted with Phosphoserine" [UniProtKB:Q14203] comment: By similarity xref: UniProtKB:Q14203 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000321 ! motor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000144 ! spindle pole relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000421 ! cytoskeleton relationship: located_in CCO:C0000434 ! microtubule relationship: located_in CCO:C0000995 ! dynein complex relationship: transformation_of CCO:B0001779 ! DCTN1_HUMAN [Term] id: CCO:B0011453 name: DCTN2_HUMAN-Phosphoserine83 def: "Protein DCTN2_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:Q13561] comment: By similarity xref: UniProtKB:Q13561 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005177 ! DCTN2_HUMAN [Term] id: CCO:B0011454 name: DDB1_HUMAN-Phosphothreonine8 def: "Protein DDB1_HUMAN with the residue 8 substituted with Phosphothreonine" [UniProtKB:Q16531] comment: By similarity xref: UniProtKB:Q16531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:B0011455 name: DDB1_HUMAN-Phosphoserine757 def: "Protein DDB1_HUMAN with the residue 757 substituted with Phosphoserine" [UniProtKB:Q16531] comment: By similarity xref: UniProtKB:Q16531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:B0011456 name: DDB1_HUMAN-Phosphoserine766 def: "Protein DDB1_HUMAN with the residue 766 substituted with Phosphoserine" [UniProtKB:Q16531] comment: By similarity xref: UniProtKB:Q16531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000279 ! damaged DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:B0011457 name: DDB2_HUMAN-Phosphoserine24 def: "Protein DDB2_HUMAN with the residue 24 substituted with Phosphoserine" [UniProtKB:Q92466] xref: UniProtKB:Q92466 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005658 ! DDB2_HUMAN [Term] id: CCO:B0011458 name: DDB2_HUMAN-Phosphoserine26 def: "Protein DDB2_HUMAN with the residue 26 substituted with Phosphoserine" [UniProtKB:Q92466] xref: UniProtKB:Q92466 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005658 ! DDB2_HUMAN [Term] id: CCO:B0011459 name: DDR1_HUMAN-Phosphotyrosine513 def: "Protein DDR1_HUMAN with the residue 513 substituted with Phosphotyrosine" [UniProtKB:Q08345] comment: by autocatalysis; By similarity xref: UniProtKB:Q08345 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006158 ! DDR1_HUMAN [Term] id: CCO:B0011460 name: DDR1_HUMAN-Phosphotyrosine792 def: "Protein DDR1_HUMAN with the residue 792 substituted with Phosphotyrosine" [UniProtKB:Q08345] comment: by autocatalysis; By similarity xref: UniProtKB:Q08345 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006158 ! DDR1_HUMAN [Term] id: CCO:B0011461 name: DDR1_HUMAN-Phosphotyrosine796 def: "Protein DDR1_HUMAN with the residue 796 substituted with Phosphotyrosine" [UniProtKB:Q08345] comment: by autocatalysis; By similarity xref: UniProtKB:Q08345 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006158 ! DDR1_HUMAN [Term] id: CCO:B0011462 name: DDR1_HUMAN-Phosphotyrosine797 def: "Protein DDR1_HUMAN with the residue 797 substituted with Phosphotyrosine" [UniProtKB:Q08345] comment: by autocatalysis; By similarity xref: UniProtKB:Q08345 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006158 ! DDR1_HUMAN [Term] id: CCO:B0011467 name: DDX24_HUMAN-Phosphoserine82 def: "Protein DDX24_HUMAN with the residue 82 substituted with Phosphoserine" [UniProtKB:Q9GZR7] xref: UniProtKB:Q9GZR7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006183 ! DDX24_HUMAN [Term] id: CCO:B0011468 name: DDX24_HUMAN-Phosphoserine166 def: "Protein DDX24_HUMAN with the residue 166 substituted with Phosphoserine" [UniProtKB:Q9GZR7] xref: UniProtKB:Q9GZR7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006183 ! DDX24_HUMAN [Term] id: CCO:B0011469 name: DDX24_HUMAN-Phosphoserine192 def: "Protein DDX24_HUMAN with the residue 192 substituted with Phosphoserine" [UniProtKB:Q9GZR7] xref: UniProtKB:Q9GZR7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006183 ! DDX24_HUMAN [Term] id: CCO:B0011470 name: DDX24_HUMAN-Phosphothreonine302 def: "Protein DDX24_HUMAN with the residue 302 substituted with Phosphothreonine" [UniProtKB:Q9GZR7] xref: UniProtKB:Q9GZR7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006183 ! DDX24_HUMAN [Term] id: CCO:B0011471 name: DDX3X_HUMAN-N-acetylserine2 def: "Protein DDX3X_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011472 name: DDX3X_HUMAN-Phosphotyrosine69 def: "Protein DDX3X_HUMAN with the residue 69 substituted with Phosphotyrosine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011473 name: DDX3X_HUMAN-Phosphoserine74 def: "Protein DDX3X_HUMAN with the residue 74 substituted with Phosphoserine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011474 name: DDX3X_HUMAN-Phosphoserine76 def: "Protein DDX3X_HUMAN with the residue 76 substituted with Phosphoserine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011475 name: DDX3X_HUMAN-Phosphoserine78 def: "Protein DDX3X_HUMAN with the residue 78 substituted with Phosphoserine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011476 name: DDX3X_HUMAN-Phosphotyrosine104 def: "Protein DDX3X_HUMAN with the residue 104 substituted with Phosphotyrosine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011477 name: DDX3X_HUMAN-Phosphoserine125 def: "Protein DDX3X_HUMAN with the residue 125 substituted with Phosphoserine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011478 name: DDX3X_HUMAN-Phosphotyrosine343 def: "Protein DDX3X_HUMAN with the residue 343 substituted with Phosphotyrosine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011479 name: DDX3X_HUMAN-Phosphoserine590 def: "Protein DDX3X_HUMAN with the residue 590 substituted with Phosphoserine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011480 name: DDX3X_HUMAN-Phosphoserine594 def: "Protein DDX3X_HUMAN with the residue 594 substituted with Phosphoserine" [UniProtKB:O00571] xref: UniProtKB:O00571 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005773 ! DDX3X_HUMAN [Term] id: CCO:B0011481 name: DDX5_HUMAN-Phosphoserine30 def: "Protein DDX5_HUMAN with the residue 30 substituted with Phosphoserine" [UniProtKB:P17844] xref: UniProtKB:P17844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005729 ! DDX5_HUMAN [Term] id: CCO:B0011482 name: DDX5_HUMAN-Phosphotyrosine297 def: "Protein DDX5_HUMAN with the residue 297 substituted with Phosphotyrosine" [UniProtKB:P17844] xref: UniProtKB:P17844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005729 ! DDX5_HUMAN [Term] id: CCO:B0011483 name: DDX5_HUMAN-Omega-N-methylated arginine502 def: "Protein DDX5_HUMAN with the residue 502 substituted with Omega-N-methylated arginine" [UniProtKB:P17844] xref: UniProtKB:P17844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005729 ! DDX5_HUMAN [Term] id: CCO:B0011484 name: DDX5_HUMAN-Phosphothreonine507 def: "Protein DDX5_HUMAN with the residue 507 substituted with Phosphothreonine" [UniProtKB:P17844] xref: UniProtKB:P17844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005729 ! DDX5_HUMAN [Term] id: CCO:B0011485 name: DDX5_HUMAN-Phosphoserine520 def: "Protein DDX5_HUMAN with the residue 520 substituted with Phosphoserine" [UniProtKB:P17844] xref: UniProtKB:P17844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005729 ! DDX5_HUMAN [Term] id: CCO:B0011486 name: DDX6_HUMAN-Phosphothreonine36 def: "Protein DDX6_HUMAN with the residue 36 substituted with Phosphothreonine" [UniProtKB:P26196] xref: UniProtKB:P26196 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006013 ! DDX6_HUMAN [Term] id: CCO:B0011501 name: DHC24_HUMAN-Phosphothreonine110 def: "Protein DHC24_HUMAN with the residue 110 substituted with Phosphothreonine" [UniProtKB:Q15392] xref: UniProtKB:Q15392 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001806 ! DHC24_HUMAN [Term] id: CCO:B0011520 name: DLG1_HUMAN-Phosphoserine232 def: "Protein DLG1_HUMAN with the residue 232 substituted with Phosphoserine" [UniProtKB:Q12959] comment: By similarity xref: UniProtKB:Q12959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001736 ! DLG1_HUMAN [Term] id: CCO:B0011521 name: DLG1_HUMAN-Phosphoserine301 def: "Protein DLG1_HUMAN with the residue 301 substituted with Phosphoserine" [UniProtKB:Q12959] comment: By similarity xref: UniProtKB:Q12959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000802 ! guanylate kinase activity relationship: has_function CCO:F0001086 ! phosphoprotein phosphatase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0001705 ! cytoskeletal protein binding relationship: has_function CCO:F0002867 ! potassium channel regulator activity relationship: has_function CCO:F0004210 ! protein kinase binding relationship: has_function CCO:F0004211 ! phosphatase binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000364 ! endoplasmic reticulum relationship: located_in CCO:C0000370 ! endoplasmic reticulum membrane relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000463 ! intercellular junction relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000780 ! basolateral plasma membrane relationship: located_in CCO:C0000936 ! cell junction relationship: located_in CCO:C0001900 ! synapse relationship: located_in CCO:C0001902 ! postsynaptic membrane relationship: transformation_of CCO:B0001736 ! DLG1_HUMAN [Term] id: CCO:B0011522 name: DLG1_HUMAN-Phosphothreonine683 def: "Protein DLG1_HUMAN with the residue 683 substituted with Phosphothreonine" [UniProtKB:Q12959] comment: By similarity xref: UniProtKB:Q12959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001736 ! DLG1_HUMAN [Term] id: CCO:B0011523 name: DLG1_HUMAN-Phosphoserine684 def: "Protein DLG1_HUMAN with the residue 684 substituted with Phosphoserine" [UniProtKB:Q12959] xref: UniProtKB:Q12959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001736 ! DLG1_HUMAN [Term] id: CCO:B0011524 name: DLG1_HUMAN-Phosphoserine687 def: "Protein DLG1_HUMAN with the residue 687 substituted with Phosphoserine" [UniProtKB:Q12959] xref: UniProtKB:Q12959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001736 ! DLG1_HUMAN [Term] id: CCO:B0011525 name: DLG5_HUMAN-Phosphothreonine984 def: "Protein DLG5_HUMAN with the residue 984 substituted with Phosphothreonine" [UniProtKB:Q8TDM6] xref: UniProtKB:Q8TDM6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001993 ! DLG5_HUMAN [Term] id: CCO:B0011526 name: DLG5_HUMAN-Phosphoserine1000 def: "Protein DLG5_HUMAN with the residue 1000 substituted with Phosphoserine" [UniProtKB:Q8TDM6] xref: UniProtKB:Q8TDM6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001993 ! DLG5_HUMAN [Term] id: CCO:B0011527 name: DLG5_HUMAN-Phosphothreonine1011 def: "Protein DLG5_HUMAN with the residue 1011 substituted with Phosphothreonine" [UniProtKB:Q8TDM6] xref: UniProtKB:Q8TDM6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001993 ! DLG5_HUMAN [Term] id: CCO:B0011528 name: DLG7_HUMAN-Phosphoserine67 def: "Protein DLG7_HUMAN with the residue 67 substituted with Phosphoserine" [UniProtKB:Q15398] comment: by CDC2; xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011529 name: DLG7_HUMAN-Phosphothreonine219 def: "Protein DLG7_HUMAN with the residue 219 substituted with Phosphothreonine" [UniProtKB:Q15398] comment: By similarity xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011530 name: DLG7_HUMAN-Phosphothreonine224 def: "Protein DLG7_HUMAN with the residue 224 substituted with Phosphothreonine" [UniProtKB:Q15398] comment: By similarity xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011531 name: DLG7_HUMAN-Phosphothreonine329 def: "Protein DLG7_HUMAN with the residue 329 substituted with Phosphothreonine" [UniProtKB:Q15398] comment: by CDC2; xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011532 name: DLG7_HUMAN-Phosphothreonine401 def: "Protein DLG7_HUMAN with the residue 401 substituted with Phosphothreonine" [UniProtKB:Q15398] comment: by CDC2; xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011533 name: DLG7_HUMAN-Phosphothreonine402 def: "Protein DLG7_HUMAN with the residue 402 substituted with Phosphothreonine" [UniProtKB:Q15398] comment: by CDC2; xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011534 name: DLG7_HUMAN-Phosphoserine618 def: "Protein DLG7_HUMAN with the residue 618 substituted with Phosphoserine" [UniProtKB:Q15398] comment: by CDC2; xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011535 name: DLG7_HUMAN-Phosphothreonine639 def: "Protein DLG7_HUMAN with the residue 639 substituted with Phosphothreonine" [UniProtKB:Q15398] comment: by CDC2; xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011536 name: DLG7_HUMAN-Phosphoserine642 def: "Protein DLG7_HUMAN with the residue 642 substituted with Phosphoserine" [UniProtKB:Q15398] comment: by CDC2; xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011537 name: DLG7_HUMAN-Phosphoserine662 def: "Protein DLG7_HUMAN with the residue 662 substituted with Phosphoserine" [UniProtKB:Q15398] xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011538 name: DLG7_HUMAN-Phosphoserine689 def: "Protein DLG7_HUMAN with the residue 689 substituted with Phosphoserine" [UniProtKB:Q15398] xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011539 name: DLG7_HUMAN-Phosphothreonine759 def: "Protein DLG7_HUMAN with the residue 759 substituted with Phosphothreonine" [UniProtKB:Q15398] comment: by CDC2; xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011540 name: DLG7_HUMAN-Phosphoserine774 def: "Protein DLG7_HUMAN with the residue 774 substituted with Phosphoserine" [UniProtKB:Q15398] xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011541 name: DLG7_HUMAN-Phosphoserine777 def: "Protein DLG7_HUMAN with the residue 777 substituted with Phosphoserine" [UniProtKB:Q15398] xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011542 name: DLG7_HUMAN-Phosphoserine839 def: "Protein DLG7_HUMAN with the residue 839 substituted with Phosphoserine" [UniProtKB:Q15398] comment: by CDC2; xref: UniProtKB:Q15398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001807 ! DLG7_HUMAN [Term] id: CCO:B0011543 name: DLRB1_HUMAN-N-acetylalanine2 def: "Protein DLRB1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9NP97] comment: By similarity xref: UniProtKB:Q9NP97 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005562 ! DLRB1_HUMAN [Term] id: CCO:B0011544 name: DMAP1_HUMAN-Phosphothreonine445 def: "Protein DMAP1_HUMAN with the residue 445 substituted with Phosphothreonine" [UniProtKB:Q9NPF5] xref: UniProtKB:Q9NPF5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005365 ! DMAP1_HUMAN [Term] id: CCO:B0011545 name: DMAP1_HUMAN-Phosphoserine456 def: "Protein DMAP1_HUMAN with the residue 456 substituted with Phosphoserine" [UniProtKB:Q9NPF5] xref: UniProtKB:Q9NPF5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005365 ! DMAP1_HUMAN [Term] id: CCO:B0011546 name: DMWD_HUMAN-Phosphoserine530 def: "Protein DMWD_HUMAN with the residue 530 substituted with Phosphoserine" [UniProtKB:Q09019] xref: UniProtKB:Q09019 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000272 ! molecular_function relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: transformation_of CCO:B0001726 ! DMWD_HUMAN [Term] id: CCO:B0011547 name: DNJA1_HUMAN-Phosphoserine83 def: "Protein DNJA1_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:P31689] xref: UniProtKB:P31689 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005835 ! DNJA1_HUMAN [Term] id: CCO:B0011548 name: DNJA1_HUMAN-Phosphoserine335 def: "Protein DNJA1_HUMAN with the residue 335 substituted with Phosphoserine" [UniProtKB:P31689] xref: UniProtKB:P31689 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005835 ! DNJA1_HUMAN [Term] id: CCO:B0011549 name: DNJA1_HUMAN-Phosphotyrosine381 def: "Protein DNJA1_HUMAN with the residue 381 substituted with Phosphotyrosine" [UniProtKB:P31689] xref: UniProtKB:P31689 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005835 ! DNJA1_HUMAN [Term] id: CCO:B0011550 name: DNJA2_HUMAN-Phosphoserine78 def: "Protein DNJA2_HUMAN with the residue 78 substituted with Phosphoserine" [UniProtKB:O60884] xref: UniProtKB:O60884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001418 ! DNJA2_HUMAN [Term] id: CCO:B0011551 name: DNJA3_HUMAN-Phosphoserine169 def: "Protein DNJA3_HUMAN with the residue 169 substituted with Phosphoserine" [UniProtKB:Q96EY1] xref: UniProtKB:Q96EY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005818 ! DNJA3_HUMAN [Term] id: CCO:B0011552 name: DNJB6_HUMAN-Phosphoserine277 def: "Protein DNJB6_HUMAN with the residue 277 substituted with Phosphoserine" [UniProtKB:O75190] xref: UniProtKB:O75190 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005696 ! DNJB6_HUMAN [Term] id: CCO:B0011553 name: DNL1_HUMAN-Phosphoserine49 def: "Protein DNL1_HUMAN with the residue 49 substituted with Phosphoserine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011554 name: DNL1_HUMAN-Phosphoserine51 def: "Protein DNL1_HUMAN with the residue 51 substituted with Phosphoserine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011555 name: DNL1_HUMAN-Phosphoserine66 def: "Protein DNL1_HUMAN with the residue 66 substituted with Phosphoserine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011556 name: DNL1_HUMAN-Phosphoserine76 def: "Protein DNL1_HUMAN with the residue 76 substituted with Phosphoserine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011557 name: DNL1_HUMAN-Phosphoserine141 def: "Protein DNL1_HUMAN with the residue 141 substituted with Phosphoserine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011558 name: DNL1_HUMAN-Phosphothreonine195 def: "Protein DNL1_HUMAN with the residue 195 substituted with Phosphothreonine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011559 name: DNL1_HUMAN-Phosphoserine201 def: "Protein DNL1_HUMAN with the residue 201 substituted with Phosphoserine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011560 name: DNL1_HUMAN-Phosphoserine230 def: "Protein DNL1_HUMAN with the residue 230 substituted with Phosphoserine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011561 name: DNL1_HUMAN-Phosphothreonine233 def: "Protein DNL1_HUMAN with the residue 233 substituted with Phosphothreonine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011562 name: DNL1_HUMAN-Phosphoserine911 def: "Protein DNL1_HUMAN with the residue 911 substituted with Phosphoserine" [UniProtKB:P18858] xref: UniProtKB:P18858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001534 ! DNL1_HUMAN [Term] id: CCO:B0011563 name: DNL3_HUMAN-Phosphothreonine122 def: "Protein DNL3_HUMAN with the residue 122 substituted with Phosphothreonine" [UniProtKB:P49916] comment: By similarity xref: UniProtKB:P49916 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000413 ! DNA ligase activity relationship: has_function CCO:F0000414 ! DNA ligase (ATP) activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0003433 ! ligase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: transformation_of CCO:B0001638 ! DNL3_HUMAN [Term] id: CCO:B0011564 name: DNL3_HUMAN-Phosphoserine123 def: "Protein DNL3_HUMAN with the residue 123 substituted with Phosphoserine" [UniProtKB:P49916] xref: UniProtKB:P49916 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001638 ! DNL3_HUMAN [Term] id: CCO:B0011566 name: DP13A_HUMAN-Phosphoserine401 def: "Protein DP13A_HUMAN with the residue 401 substituted with Phosphoserine" [UniProtKB:Q9UKG1] comment: By similarity xref: UniProtKB:Q9UKG1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002219 ! DP13A_HUMAN [Term] id: CCO:B0011567 name: DP13A_HUMAN-Phosphoserine691 def: "Protein DP13A_HUMAN with the residue 691 substituted with Phosphoserine" [UniProtKB:Q9UKG1] xref: UniProtKB:Q9UKG1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000351 ! endosome relationship: located_in CCO:C0000713 ! endosome membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000805 ! NuRD complex relationship: located_in CCO:C0001339 ! early endosome membrane relationship: transformation_of CCO:B0002219 ! DP13A_HUMAN [Term] id: CCO:B0011568 name: DPOA2_HUMAN-Phosphothreonine127 def: "Protein DPOA2_HUMAN with the residue 127 substituted with Phosphothreonine" [UniProtKB:Q14181] xref: UniProtKB:Q14181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005509 ! DPOA2_HUMAN [Term] id: CCO:B0011569 name: DPOA2_HUMAN-Phosphothreonine130 def: "Protein DPOA2_HUMAN with the residue 130 substituted with Phosphothreonine" [UniProtKB:Q14181] xref: UniProtKB:Q14181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005509 ! DPOA2_HUMAN [Term] id: CCO:B0011570 name: DPOA2_HUMAN-Phosphoserine141 def: "Protein DPOA2_HUMAN with the residue 141 substituted with Phosphoserine" [UniProtKB:Q14181] xref: UniProtKB:Q14181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005509 ! DPOA2_HUMAN [Term] id: CCO:B0011571 name: DPOA2_HUMAN-Phosphoserine152 def: "Protein DPOA2_HUMAN with the residue 152 substituted with Phosphoserine" [UniProtKB:Q14181] xref: UniProtKB:Q14181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005509 ! DPOA2_HUMAN [Term] id: CCO:B0011572 name: DPOD3_HUMAN-Phosphoserine307 def: "Protein DPOD3_HUMAN with the residue 307 substituted with Phosphoserine" [UniProtKB:Q15054] xref: UniProtKB:Q15054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:B0011573 name: DPOD3_HUMAN-Phosphoserine407 def: "Protein DPOD3_HUMAN with the residue 407 substituted with Phosphoserine" [UniProtKB:Q15054] xref: UniProtKB:Q15054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:B0011574 name: DPOD3_HUMAN-Phosphoserine409 def: "Protein DPOD3_HUMAN with the residue 409 substituted with Phosphoserine" [UniProtKB:Q15054] xref: UniProtKB:Q15054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:B0011575 name: DPOD3_HUMAN-Phosphothreonine411 def: "Protein DPOD3_HUMAN with the residue 411 substituted with Phosphothreonine" [UniProtKB:Q15054] xref: UniProtKB:Q15054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:B0011576 name: DPOD3_HUMAN-Phosphoserine413 def: "Protein DPOD3_HUMAN with the residue 413 substituted with Phosphoserine" [UniProtKB:Q15054] xref: UniProtKB:Q15054 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:B0011577 name: DPOE1_HUMAN-Phosphoserine1940 def: "Protein DPOE1_HUMAN with the residue 1940 substituted with Phosphoserine" [UniProtKB:Q07864] xref: UniProtKB:Q07864 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001724 ! DPOE1_HUMAN [Term] id: CCO:B0011578 name: DPOE3_HUMAN-Phosphoserine122 def: "Protein DPOE3_HUMAN with the residue 122 substituted with Phosphoserine" [UniProtKB:Q9NRF9] xref: UniProtKB:Q9NRF9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005885 ! DPOE3_HUMAN [Term] id: CCO:B0011579 name: DPOE4_HUMAN-Phosphoserine25 def: "Protein DPOE4_HUMAN with the residue 25 substituted with Phosphoserine" [UniProtKB:Q9NR33] xref: UniProtKB:Q9NR33 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005905 ! DPOE4_HUMAN [Term] id: CCO:B0011580 name: DPOLA_HUMAN-Phosphoserine186 def: "Protein DPOLA_HUMAN with the residue 186 substituted with Phosphoserine" [UniProtKB:P09884] comment: By similarity xref: UniProtKB:P09884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001503 ! DPOLA_HUMAN [Term] id: CCO:B0011581 name: DPYL1_HUMAN-Phosphothreonine509 def: "Protein DPYL1_HUMAN with the residue 509 substituted with Phosphothreonine" [UniProtKB:Q14194] comment: By similarity xref: UniProtKB:Q14194 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006074 ! DPYL1_HUMAN [Term] id: CCO:B0011582 name: DREB_HUMAN-N-acetylalanine2 def: "Protein DREB_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q16643] xref: UniProtKB:Q16643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:B0011583 name: DREB_HUMAN-Phosphoserine134 def: "Protein DREB_HUMAN with the residue 134 substituted with Phosphoserine" [UniProtKB:Q16643] comment: By similarity xref: UniProtKB:Q16643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:B0011584 name: DREB_HUMAN-Phosphoserine141 def: "Protein DREB_HUMAN with the residue 141 substituted with Phosphoserine" [UniProtKB:Q16643] xref: UniProtKB:Q16643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:B0011585 name: DREB_HUMAN-Phosphoserine142 def: "Protein DREB_HUMAN with the residue 142 substituted with Phosphoserine" [UniProtKB:Q16643] xref: UniProtKB:Q16643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:B0011586 name: DREB_HUMAN-Phosphoserine337 def: "Protein DREB_HUMAN with the residue 337 substituted with Phosphoserine" [UniProtKB:Q16643] comment: By similarity xref: UniProtKB:Q16643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:B0011587 name: DREB_HUMAN-Phosphoserine339 def: "Protein DREB_HUMAN with the residue 339 substituted with Phosphoserine" [UniProtKB:Q16643] xref: UniProtKB:Q16643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:B0011588 name: DREB_HUMAN-Phosphoserine342 def: "Protein DREB_HUMAN with the residue 342 substituted with Phosphoserine" [UniProtKB:Q16643] comment: By similarity xref: UniProtKB:Q16643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:B0011589 name: DREB_HUMAN-Phosphothreonine346 def: "Protein DREB_HUMAN with the residue 346 substituted with Phosphothreonine" [UniProtKB:Q16643] xref: UniProtKB:Q16643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:B0011590 name: DREB_HUMAN-Phosphotyrosine622 def: "Protein DREB_HUMAN with the residue 622 substituted with Phosphotyrosine" [UniProtKB:Q16643] xref: UniProtKB:Q16643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:B0011591 name: DSN1_HUMAN-Phosphoserine28 def: "Protein DSN1_HUMAN with the residue 28 substituted with Phosphoserine" [UniProtKB:Q9H410] xref: UniProtKB:Q9H410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002134 ! DSN1_HUMAN [Term] id: CCO:B0011592 name: DSN1_HUMAN-Phosphoserine30 def: "Protein DSN1_HUMAN with the residue 30 substituted with Phosphoserine" [UniProtKB:Q9H410] xref: UniProtKB:Q9H410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002134 ! DSN1_HUMAN [Term] id: CCO:B0011593 name: DSN1_HUMAN-Phosphoserine86 def: "Protein DSN1_HUMAN with the residue 86 substituted with Phosphoserine" [UniProtKB:Q9H410] xref: UniProtKB:Q9H410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002134 ! DSN1_HUMAN [Term] id: CCO:B0011594 name: DTL_HUMAN-Phosphoserine426 def: "Protein DTL_HUMAN with the residue 426 substituted with Phosphoserine" [UniProtKB:Q9NZJ0] xref: UniProtKB:Q9NZJ0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005656 ! DTL_HUMAN [Term] id: CCO:B0011595 name: DTL_HUMAN-Phosphothreonine516 def: "Protein DTL_HUMAN with the residue 516 substituted with Phosphothreonine" [UniProtKB:Q9NZJ0] comment: By similarity xref: UniProtKB:Q9NZJ0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005656 ! DTL_HUMAN [Term] id: CCO:B0011596 name: DTL_HUMAN-Phosphoserine599 def: "Protein DTL_HUMAN with the residue 599 substituted with Phosphoserine" [UniProtKB:Q9NZJ0] comment: By similarity xref: UniProtKB:Q9NZJ0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005656 ! DTL_HUMAN [Term] id: CCO:B0011597 name: DTL_HUMAN-Phosphoserine717 def: "Protein DTL_HUMAN with the residue 717 substituted with Phosphoserine" [UniProtKB:Q9NZJ0] xref: UniProtKB:Q9NZJ0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005656 ! DTL_HUMAN [Term] id: CCO:B0011602 name: DYN2_HUMAN-Phosphoserine298 def: "Protein DYN2_HUMAN with the residue 298 substituted with Phosphoserine" [UniProtKB:P50570] comment: By similarity xref: UniProtKB:P50570 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001643 ! DYN2_HUMAN [Term] id: CCO:B0011603 name: DYN2_HUMAN-Phosphoserine302 def: "Protein DYN2_HUMAN with the residue 302 substituted with Phosphoserine" [UniProtKB:P50570] comment: By similarity xref: UniProtKB:P50570 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001643 ! DYN2_HUMAN [Term] id: CCO:B0011604 name: DYN2_HUMAN-Phosphotyrosine597 def: "Protein DYN2_HUMAN with the residue 597 substituted with Phosphotyrosine" [UniProtKB:P50570] comment: By similarity xref: UniProtKB:P50570 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001643 ! DYN2_HUMAN [Term] id: CCO:B0011605 name: DYN2_HUMAN-Phosphothreonine766 def: "Protein DYN2_HUMAN with the residue 766 substituted with Phosphothreonine" [UniProtKB:P50570] xref: UniProtKB:P50570 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001643 ! DYN2_HUMAN [Term] id: CCO:B0011606 name: E2AK1_HUMAN-Phosphoserine275 def: "Protein E2AK1_HUMAN with the residue 275 substituted with Phosphoserine" [UniProtKB:Q9BQI3] xref: UniProtKB:Q9BQI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005674 ! E2AK1_HUMAN [Term] id: CCO:B0011607 name: E2AK1_HUMAN-Phosphoserine276 def: "Protein E2AK1_HUMAN with the residue 276 substituted with Phosphoserine" [UniProtKB:Q9BQI3] xref: UniProtKB:Q9BQI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005674 ! E2AK1_HUMAN [Term] id: CCO:B0011608 name: E2AK1_HUMAN-Phosphoserine277 def: "Protein E2AK1_HUMAN with the residue 277 substituted with Phosphoserine" [UniProtKB:Q9BQI3] xref: UniProtKB:Q9BQI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005674 ! E2AK1_HUMAN [Term] id: CCO:B0011609 name: E2AK1_HUMAN-Phosphoserine278 def: "Protein E2AK1_HUMAN with the residue 278 substituted with Phosphoserine" [UniProtKB:Q9BQI3] xref: UniProtKB:Q9BQI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005674 ! E2AK1_HUMAN [Term] id: CCO:B0011610 name: E2AK1_HUMAN-Phosphothreonine488 def: "Protein E2AK1_HUMAN with the residue 488 substituted with Phosphothreonine" [UniProtKB:Q9BQI3] comment: by autocatalysis; By similarity xref: UniProtKB:Q9BQI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005674 ! E2AK1_HUMAN [Term] id: CCO:B0011611 name: E2AK2_HUMAN-Phosphoserine83 def: "Protein E2AK2_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:P19525] comment: by autocatalysis; Probable xref: UniProtKB:P19525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001535 ! E2AK2_HUMAN [Term] id: CCO:B0011612 name: E2AK2_HUMAN-Phosphothreonine88 def: "Protein E2AK2_HUMAN with the residue 88 substituted with Phosphothreonine" [UniProtKB:P19525] comment: by autocatalysis; Probable xref: UniProtKB:P19525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000308 ! RNA binding relationship: has_function CCO:F0000310 ! double-stranded RNA binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001061 ! eukaryotic translation initiation factor 2alpha kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0002006 ! protein phosphatase type 2A regulator activity relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: transformation_of CCO:B0001535 ! E2AK2_HUMAN [Term] id: CCO:B0011613 name: E2AK2_HUMAN-Phosphothreonine89 def: "Protein E2AK2_HUMAN with the residue 89 substituted with Phosphothreonine" [UniProtKB:P19525] comment: by autocatalysis; Probable xref: UniProtKB:P19525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001535 ! E2AK2_HUMAN [Term] id: CCO:B0011614 name: E2AK2_HUMAN-Phosphothreonine90 def: "Protein E2AK2_HUMAN with the residue 90 substituted with Phosphothreonine" [UniProtKB:P19525] comment: by autocatalysis; Probable xref: UniProtKB:P19525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001535 ! E2AK2_HUMAN [Term] id: CCO:B0011615 name: E2AK2_HUMAN-Phosphoserine242 def: "Protein E2AK2_HUMAN with the residue 242 substituted with Phosphoserine" [UniProtKB:P19525] comment: by autocatalysis; Probable xref: UniProtKB:P19525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001535 ! E2AK2_HUMAN [Term] id: CCO:B0011616 name: E2AK2_HUMAN-Phosphothreonine255 def: "Protein E2AK2_HUMAN with the residue 255 substituted with Phosphothreonine" [UniProtKB:P19525] comment: by autocatalysis; Probable xref: UniProtKB:P19525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001535 ! E2AK2_HUMAN [Term] id: CCO:B0011617 name: E2AK2_HUMAN-Phosphothreonine258 def: "Protein E2AK2_HUMAN with the residue 258 substituted with Phosphothreonine" [UniProtKB:P19525] comment: by autocatalysis; Probable xref: UniProtKB:P19525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001535 ! E2AK2_HUMAN [Term] id: CCO:B0011618 name: E2AK2_HUMAN-Phosphothreonine446 def: "Protein E2AK2_HUMAN with the residue 446 substituted with Phosphothreonine" [UniProtKB:P19525] comment: by autocatalysis; xref: UniProtKB:P19525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001535 ! E2AK2_HUMAN [Term] id: CCO:B0011619 name: E2AK2_HUMAN-Phosphothreonine451 def: "Protein E2AK2_HUMAN with the residue 451 substituted with Phosphothreonine" [UniProtKB:P19525] comment: by autocatalysis; xref: UniProtKB:P19525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001535 ! E2AK2_HUMAN [Term] id: CCO:B0011620 name: E2F1_HUMAN-Phosphoserine375 def: "Protein E2F1_HUMAN with the residue 375 substituted with Phosphoserine" [UniProtKB:Q01094] xref: UniProtKB:Q01094 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001713 ! E2F1_HUMAN [Term] id: CCO:B0011621 name: E2F6_HUMAN-Phosphoserine67 def: "Protein E2F6_HUMAN with the residue 67 substituted with Phosphoserine" [UniProtKB:O75461] comment: By similarity xref: UniProtKB:O75461 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001429 ! E2F6_HUMAN [Term] id: CCO:B0011622 name: EAF1_HUMAN-Phosphoserine158 def: "Protein EAF1_HUMAN with the residue 158 substituted with Phosphoserine" [UniProtKB:Q96JC9] comment: By similarity xref: UniProtKB:Q96JC9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005363 ! EAF1_HUMAN [Term] id: CCO:B0011623 name: EAF1_HUMAN-Phosphoserine165 def: "Protein EAF1_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:Q96JC9] xref: UniProtKB:Q96JC9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005363 ! EAF1_HUMAN [Term] id: CCO:B0011624 name: EDC3_HUMAN-Phosphoserine131 def: "Protein EDC3_HUMAN with the residue 131 substituted with Phosphoserine" [UniProtKB:Q96F86] xref: UniProtKB:Q96F86 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005717 ! EDC3_HUMAN [Term] id: CCO:B0011625 name: EDC4_HUMAN-Phosphothreonine693 def: "Protein EDC4_HUMAN with the residue 693 substituted with Phosphothreonine" [UniProtKB:Q6P2E9] xref: UniProtKB:Q6P2E9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:B0011626 name: EDC4_HUMAN-Phosphoserine729 def: "Protein EDC4_HUMAN with the residue 729 substituted with Phosphoserine" [UniProtKB:Q6P2E9] xref: UniProtKB:Q6P2E9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:B0011627 name: EDC4_HUMAN-Phosphoserine741 def: "Protein EDC4_HUMAN with the residue 741 substituted with Phosphoserine" [UniProtKB:Q6P2E9] xref: UniProtKB:Q6P2E9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:B0011628 name: EDC4_HUMAN-Phosphoserine844 def: "Protein EDC4_HUMAN with the residue 844 substituted with Phosphoserine" [UniProtKB:Q6P2E9] xref: UniProtKB:Q6P2E9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:B0011629 name: EDC4_HUMAN-Phosphoserine875 def: "Protein EDC4_HUMAN with the residue 875 substituted with Phosphoserine" [UniProtKB:Q6P2E9] comment: By similarity xref: UniProtKB:Q6P2E9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:B0011630 name: EDC4_HUMAN-Phosphoserine879 def: "Protein EDC4_HUMAN with the residue 879 substituted with Phosphoserine" [UniProtKB:Q6P2E9] comment: By similarity xref: UniProtKB:Q6P2E9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:B0011631 name: EDC4_HUMAN-Phosphoserine887 def: "Protein EDC4_HUMAN with the residue 887 substituted with Phosphoserine" [UniProtKB:Q6P2E9] comment: By similarity xref: UniProtKB:Q6P2E9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:B0011632 name: EDC4_HUMAN-Phosphoserine1067 def: "Protein EDC4_HUMAN with the residue 1067 substituted with Phosphoserine" [UniProtKB:Q6P2E9] xref: UniProtKB:Q6P2E9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:B0011633 name: EDC4_HUMAN-Phosphothreonine1072 def: "Protein EDC4_HUMAN with the residue 1072 substituted with Phosphothreonine" [UniProtKB:Q6P2E9] xref: UniProtKB:Q6P2E9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:B0011634 name: EF1A1_HUMAN-Phosphotyrosine29 def: "Protein EF1A1_HUMAN with the residue 29 substituted with Phosphotyrosine" [UniProtKB:P68104] xref: UniProtKB:P68104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:B0011635 name: EF1A1_HUMAN-N6,N6,N6-trimethyllysine36 def: "Protein EF1A1_HUMAN with the residue 36 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P68104] comment: By similarity xref: UniProtKB:P68104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:B0011636 name: EF1A1_HUMAN-N6,N6-dimethyllysine55 def: "Protein EF1A1_HUMAN with the residue 55 substituted with N6,N6-dimethyllysine" [UniProtKB:P68104] comment: By similarity xref: UniProtKB:P68104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:B0011637 name: EF1A1_HUMAN-N6,N6,N6-trimethyllysine79 def: "Protein EF1A1_HUMAN with the residue 79 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P68104] comment: By similarity xref: UniProtKB:P68104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:B0011638 name: EF1A1_HUMAN-Phosphotyrosine162 def: "Protein EF1A1_HUMAN with the residue 162 substituted with Phosphotyrosine" [UniProtKB:P68104] xref: UniProtKB:P68104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:B0011639 name: EF1A1_HUMAN-N6,N6-dimethyllysine165 def: "Protein EF1A1_HUMAN with the residue 165 substituted with N6,N6-dimethyllysine" [UniProtKB:P68104] comment: By similarity xref: UniProtKB:P68104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:B0011640 name: EF1A1_HUMAN-N6,N6,N6-trimethyllysine318 def: "Protein EF1A1_HUMAN with the residue 318 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P68104] comment: alternate; By similarity xref: UniProtKB:P68104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:B0011641 name: EF1A1_HUMAN-N6-acetyllysine318 def: "Protein EF1A1_HUMAN with the residue 318 substituted with N6-acetyllysine" [UniProtKB:P68104] comment: alternate; xref: UniProtKB:P68104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:B0011642 name: EF1B_HUMAN-Phosphothreonine93 def: "Protein EF1B_HUMAN with the residue 93 substituted with Phosphothreonine" [UniProtKB:P24534] xref: UniProtKB:P24534 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005752 ! EF1B_HUMAN [Term] id: CCO:B0011643 name: EF1B_HUMAN-Phosphoserine95 def: "Protein EF1B_HUMAN with the residue 95 substituted with Phosphoserine" [UniProtKB:P24534] xref: UniProtKB:P24534 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005752 ! EF1B_HUMAN [Term] id: CCO:B0011644 name: EF1B_HUMAN-Phosphoserine106 def: "Protein EF1B_HUMAN with the residue 106 substituted with Phosphoserine" [UniProtKB:P24534] xref: UniProtKB:P24534 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005752 ! EF1B_HUMAN [Term] id: CCO:B0011645 name: EF1B_HUMAN-Phosphotyrosine126 def: "Protein EF1B_HUMAN with the residue 126 substituted with Phosphotyrosine" [UniProtKB:P24534] xref: UniProtKB:P24534 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005752 ! EF1B_HUMAN [Term] id: CCO:B0011646 name: EF1B_HUMAN-Phosphoserine128 def: "Protein EF1B_HUMAN with the residue 128 substituted with Phosphoserine" [UniProtKB:P24534] xref: UniProtKB:P24534 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005752 ! EF1B_HUMAN [Term] id: CCO:B0011647 name: EF1B_HUMAN-Phosphoserine141 def: "Protein EF1B_HUMAN with the residue 141 substituted with Phosphoserine" [UniProtKB:P24534] xref: UniProtKB:P24534 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005752 ! EF1B_HUMAN [Term] id: CCO:B0011648 name: EF1G_HUMAN-N-acetylalanine2 def: "Protein EF1G_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P26641] xref: UniProtKB:P26641 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006079 ! EF1G_HUMAN [Term] id: CCO:B0011649 name: EF1G_HUMAN-Phosphothreonine43 def: "Protein EF1G_HUMAN with the residue 43 substituted with Phosphothreonine" [UniProtKB:P26641] xref: UniProtKB:P26641 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006079 ! EF1G_HUMAN [Term] id: CCO:B0011650 name: EFNB1_HUMAN-Phosphoserine287 def: "Protein EFNB1_HUMAN with the residue 287 substituted with Phosphoserine" [UniProtKB:P98172] comment: By similarity xref: UniProtKB:P98172 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005815 ! EFNB1_HUMAN [Term] id: CCO:B0011651 name: EGFR_HUMAN-Phosphothreonine678 def: "Protein EGFR_HUMAN with the residue 678 substituted with Phosphothreonine" [UniProtKB:P00533] comment: by PKC; xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011652 name: EGFR_HUMAN-Phosphothreonine693 def: "Protein EGFR_HUMAN with the residue 693 substituted with Phosphothreonine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011653 name: EGFR_HUMAN-Phosphoserine695 def: "Protein EGFR_HUMAN with the residue 695 substituted with Phosphoserine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011654 name: EGFR_HUMAN-Phosphotyrosine978 def: "Protein EGFR_HUMAN with the residue 978 substituted with Phosphotyrosine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011655 name: EGFR_HUMAN-Phosphoserine991 def: "Protein EGFR_HUMAN with the residue 991 substituted with Phosphoserine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011656 name: EGFR_HUMAN-Phosphoserine995 def: "Protein EGFR_HUMAN with the residue 995 substituted with Phosphoserine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011657 name: EGFR_HUMAN-Phosphotyrosine998 def: "Protein EGFR_HUMAN with the residue 998 substituted with Phosphotyrosine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011658 name: EGFR_HUMAN-Phosphoserine1026 def: "Protein EGFR_HUMAN with the residue 1026 substituted with Phosphoserine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011659 name: EGFR_HUMAN-Phosphoserine1064 def: "Protein EGFR_HUMAN with the residue 1064 substituted with Phosphoserine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011660 name: EGFR_HUMAN-Phosphotyrosine1069 def: "Protein EGFR_HUMAN with the residue 1069 substituted with Phosphotyrosine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011661 name: EGFR_HUMAN-Phosphoserine1070 def: "Protein EGFR_HUMAN with the residue 1070 substituted with Phosphoserine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011662 name: EGFR_HUMAN-Phosphoserine1071 def: "Protein EGFR_HUMAN with the residue 1071 substituted with Phosphoserine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011663 name: EGFR_HUMAN-Phosphotyrosine1092 def: "Protein EGFR_HUMAN with the residue 1092 substituted with Phosphotyrosine" [UniProtKB:P00533] comment: by autocatalysis; xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011664 name: EGFR_HUMAN-Phosphotyrosine1110 def: "Protein EGFR_HUMAN with the residue 1110 substituted with Phosphotyrosine" [UniProtKB:P00533] comment: by autocatalysis; xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011665 name: EGFR_HUMAN-Phosphotyrosine1138 def: "Protein EGFR_HUMAN with the residue 1138 substituted with Phosphotyrosine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011666 name: EGFR_HUMAN-Phosphoserine1166 def: "Protein EGFR_HUMAN with the residue 1166 substituted with Phosphoserine" [UniProtKB:P00533] xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011667 name: EGFR_HUMAN-Phosphotyrosine1172 def: "Protein EGFR_HUMAN with the residue 1172 substituted with Phosphotyrosine" [UniProtKB:P00533] comment: by autocatalysis; xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011668 name: EGFR_HUMAN-Phosphotyrosine1197 def: "Protein EGFR_HUMAN with the residue 1197 substituted with Phosphotyrosine" [UniProtKB:P00533] comment: by autocatalysis; xref: UniProtKB:P00533 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001462 ! EGFR_HUMAN [Term] id: CCO:B0011669 name: EHMT1_HUMAN-Phosphoserine466 def: "Protein EHMT1_HUMAN with the residue 466 substituted with Phosphoserine" [UniProtKB:Q9H9B1] xref: UniProtKB:Q9H9B1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006006 ! EHMT1_HUMAN [Term] id: CCO:B0011670 name: ELF1_HUMAN-Phosphoserine168 def: "Protein ELF1_HUMAN with the residue 168 substituted with Phosphoserine" [UniProtKB:P32519] xref: UniProtKB:P32519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006027 ! ELF1_HUMAN [Term] id: CCO:B0011671 name: ELF1_HUMAN-Phosphoserine432 def: "Protein ELF1_HUMAN with the residue 432 substituted with Phosphoserine" [UniProtKB:P32519] xref: UniProtKB:P32519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006027 ! ELF1_HUMAN [Term] id: CCO:B0011672 name: ELF1_HUMAN-Phosphoserine474 def: "Protein ELF1_HUMAN with the residue 474 substituted with Phosphoserine" [UniProtKB:P32519] xref: UniProtKB:P32519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006027 ! ELF1_HUMAN [Term] id: CCO:B0011673 name: ELF1_HUMAN-Phosphothreonine566 def: "Protein ELF1_HUMAN with the residue 566 substituted with Phosphothreonine" [UniProtKB:P32519] xref: UniProtKB:P32519 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006027 ! ELF1_HUMAN [Term] id: CCO:B0011674 name: ELK1_HUMAN-Phosphoserine324 def: "Protein ELK1_HUMAN with the residue 324 substituted with Phosphoserine" [UniProtKB:P19419] comment: by MAPK1; xref: UniProtKB:P19419 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005637 ! ELK1_HUMAN [Term] id: CCO:B0011675 name: ELK1_HUMAN-Phosphothreonine336 def: "Protein ELK1_HUMAN with the residue 336 substituted with Phosphothreonine" [UniProtKB:P19419] comment: by MAPK1; xref: UniProtKB:P19419 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005637 ! ELK1_HUMAN [Term] id: CCO:B0011676 name: ELK1_HUMAN-Phosphoserine383 def: "Protein ELK1_HUMAN with the residue 383 substituted with Phosphoserine" [UniProtKB:P19419] comment: by MAPK1; xref: UniProtKB:P19419 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005637 ! ELK1_HUMAN [Term] id: CCO:B0011677 name: ELK1_HUMAN-Phosphoserine389 def: "Protein ELK1_HUMAN with the residue 389 substituted with Phosphoserine" [UniProtKB:P19419] comment: by MAPK1; xref: UniProtKB:P19419 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005637 ! ELK1_HUMAN [Term] id: CCO:B0011678 name: ELK1_HUMAN-Phosphoserine422 def: "Protein ELK1_HUMAN with the residue 422 substituted with Phosphoserine" [UniProtKB:P19419] comment: by MAPK1; xref: UniProtKB:P19419 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005637 ! ELK1_HUMAN [Term] id: CCO:B0011679 name: ELOB_HUMAN-N-acetylmethionine1 def: "Protein ELOB_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:Q15370] comment: By similarity xref: UniProtKB:Q15370 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005668 ! ELOB_HUMAN [Term] id: CCO:B0011680 name: EMAL4_HUMAN-Phosphoserine87 def: "Protein EMAL4_HUMAN with the residue 87 substituted with Phosphoserine" [UniProtKB:Q9HC35] xref: UniProtKB:Q9HC35 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002144 ! EMAL4_HUMAN [Term] id: CCO:B0011681 name: EMAL4_HUMAN-Phosphoserine144 def: "Protein EMAL4_HUMAN with the residue 144 substituted with Phosphoserine" [UniProtKB:Q9HC35] xref: UniProtKB:Q9HC35 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002144 ! EMAL4_HUMAN [Term] id: CCO:B0011682 name: EMAL4_HUMAN-Phosphoserine146 def: "Protein EMAL4_HUMAN with the residue 146 substituted with Phosphoserine" [UniProtKB:Q9HC35] xref: UniProtKB:Q9HC35 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002144 ! EMAL4_HUMAN [Term] id: CCO:B0011683 name: EMAL4_HUMAN-Phosphotyrosine226 def: "Protein EMAL4_HUMAN with the residue 226 substituted with Phosphotyrosine" [UniProtKB:Q9HC35] xref: UniProtKB:Q9HC35 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002144 ! EMAL4_HUMAN [Term] id: CCO:B0011684 name: EMAL4_HUMAN-Phosphotyrosine499 def: "Protein EMAL4_HUMAN with the residue 499 substituted with Phosphotyrosine" [UniProtKB:Q9HC35] xref: UniProtKB:Q9HC35 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002144 ! EMAL4_HUMAN [Term] id: CCO:B0011685 name: EMAL4_HUMAN-Phosphoserine502 def: "Protein EMAL4_HUMAN with the residue 502 substituted with Phosphoserine" [UniProtKB:Q9HC35] xref: UniProtKB:Q9HC35 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002144 ! EMAL4_HUMAN [Term] id: CCO:B0011686 name: EMAL4_HUMAN-Phosphothreonine899 def: "Protein EMAL4_HUMAN with the residue 899 substituted with Phosphothreonine" [UniProtKB:Q9HC35] xref: UniProtKB:Q9HC35 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002144 ! EMAL4_HUMAN [Term] id: CCO:B0011687 name: ENOA_HUMAN-Phosphotyrosine44 def: "Protein ENOA_HUMAN with the residue 44 substituted with Phosphotyrosine" [UniProtKB:P06733] xref: UniProtKB:P06733 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005779 ! ENOA_HUMAN [Term] id: CCO:B0011688 name: ENOA_HUMAN-Phosphotyrosine57 def: "Protein ENOA_HUMAN with the residue 57 substituted with Phosphotyrosine" [UniProtKB:P06733] xref: UniProtKB:P06733 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005779 ! ENOA_HUMAN [Term] id: CCO:B0011689 name: ENOA_HUMAN-Phosphoserine63 def: "Protein ENOA_HUMAN with the residue 63 substituted with Phosphoserine" [UniProtKB:P06733] xref: UniProtKB:P06733 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005779 ! ENOA_HUMAN [Term] id: CCO:B0011690 name: ENOA_HUMAN-N6-acetyllysine71 def: "Protein ENOA_HUMAN with the residue 71 substituted with N6-acetyllysine" [UniProtKB:P06733] xref: UniProtKB:P06733 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005779 ! ENOA_HUMAN [Term] id: CCO:B0011691 name: ENOA_HUMAN-Phosphothreonine72 def: "Protein ENOA_HUMAN with the residue 72 substituted with Phosphothreonine" [UniProtKB:P06733] xref: UniProtKB:P06733 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005779 ! ENOA_HUMAN [Term] id: CCO:B0011692 name: ENOA_HUMAN-Phosphoserine263 def: "Protein ENOA_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:P06733] comment: By similarity xref: UniProtKB:P06733 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005779 ! ENOA_HUMAN [Term] id: CCO:B0011693 name: ENOA_HUMAN-Phosphotyrosine287 def: "Protein ENOA_HUMAN with the residue 287 substituted with Phosphotyrosine" [UniProtKB:P06733] xref: UniProtKB:P06733 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005779 ! ENOA_HUMAN [Term] id: CCO:B0011694 name: ENOG_HUMAN-Phosphotyrosine44 def: "Protein ENOG_HUMAN with the residue 44 substituted with Phosphotyrosine" [UniProtKB:P09104] xref: UniProtKB:P09104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006270 ! ENOG_HUMAN [Term] id: CCO:B0011695 name: ENOG_HUMAN-Phosphoserine80 def: "Protein ENOG_HUMAN with the residue 80 substituted with Phosphoserine" [UniProtKB:P09104] comment: By similarity xref: UniProtKB:P09104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006270 ! ENOG_HUMAN [Term] id: CCO:B0011696 name: EP15_HUMAN-Phosphoserine323 def: "Protein EP15_HUMAN with the residue 323 substituted with Phosphoserine" [UniProtKB:P42566] xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0011697 name: EP15_HUMAN-Phosphoserine324 def: "Protein EP15_HUMAN with the residue 324 substituted with Phosphoserine" [UniProtKB:P42566] xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0011698 name: EP15_HUMAN-Phosphoserine485 def: "Protein EP15_HUMAN with the residue 485 substituted with Phosphoserine" [UniProtKB:P42566] xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0011699 name: EP15_HUMAN-Phosphoserine562 def: "Protein EP15_HUMAN with the residue 562 substituted with Phosphoserine" [UniProtKB:P42566] comment: By similarity xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0011700 name: EP15_HUMAN-Phosphoserine563 def: "Protein EP15_HUMAN with the residue 563 substituted with Phosphoserine" [UniProtKB:P42566] comment: By similarity xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0011701 name: EP15_HUMAN-Phosphothreonine779 def: "Protein EP15_HUMAN with the residue 779 substituted with Phosphothreonine" [UniProtKB:P42566] comment: By similarity xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0011702 name: EP15_HUMAN-Phosphoserine814 def: "Protein EP15_HUMAN with the residue 814 substituted with Phosphoserine" [UniProtKB:P42566] xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0011703 name: EP15_HUMAN-Phosphotyrosine849 def: "Protein EP15_HUMAN with the residue 849 substituted with Phosphotyrosine" [UniProtKB:P42566] comment: by EGFR; By similarity xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0011704 name: EP300_HUMAN-Omega-N-methylated arginine580 def: "Protein EP300_HUMAN with the residue 580 substituted with Omega-N-methylated arginine" [UniProtKB:Q09472] xref: UniProtKB:Q09472 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:B0011705 name: EP300_HUMAN-Omega-N-methylated arginine604 def: "Protein EP300_HUMAN with the residue 604 substituted with Omega-N-methylated arginine" [UniProtKB:Q09472] xref: UniProtKB:Q09472 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0000299 ! transcription cofactor activity relationship: has_function CCO:F0000300 ! transcription coactivator activity relationship: has_function CCO:F0000813 ! histone acetyltransferase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0001738 ! transcription factor binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0003130 ! acetyltransferase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000011 ! histone acetyltransferase complex relationship: located_in CCO:C0000252 ! nucleus relationship: transformation_of CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:B0011706 name: EP300_HUMAN-N6-acetyllysine1554 def: "Protein EP300_HUMAN with the residue 1554 substituted with N6-acetyllysine" [UniProtKB:Q09472] xref: UniProtKB:Q09472 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:B0011707 name: EP300_HUMAN-N6-acetyllysine1555 def: "Protein EP300_HUMAN with the residue 1555 substituted with N6-acetyllysine" [UniProtKB:Q09472] xref: UniProtKB:Q09472 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:B0011708 name: EP300_HUMAN-N6-acetyllysine1558 def: "Protein EP300_HUMAN with the residue 1558 substituted with N6-acetyllysine" [UniProtKB:Q09472] xref: UniProtKB:Q09472 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:B0011709 name: EP300_HUMAN-N6-acetyllysine1560 def: "Protein EP300_HUMAN with the residue 1560 substituted with N6-acetyllysine" [UniProtKB:Q09472] xref: UniProtKB:Q09472 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:B0011710 name: EP300_HUMAN-dimethylarginine2142 def: "Protein EP300_HUMAN with the residue 2142 substituted with dimethylarginine" [UniProtKB:Q09472] comment: alternate; xref: UniProtKB:Q09472 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:B0011711 name: EP300_HUMAN-Citrulline2142 def: "Protein EP300_HUMAN with the residue 2142 substituted with Citrulline" [UniProtKB:Q09472] comment: alternate; xref: UniProtKB:Q09472 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:B0011712 name: EP400_HUMAN-Phosphoserine736 def: "Protein EP400_HUMAN with the residue 736 substituted with Phosphoserine" [UniProtKB:Q96L91] xref: UniProtKB:Q96L91 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005916 ! EP400_HUMAN [Term] id: CCO:B0011713 name: EP400_HUMAN-Phosphoserine755 def: "Protein EP400_HUMAN with the residue 755 substituted with Phosphoserine" [UniProtKB:Q96L91] comment: By similarity xref: UniProtKB:Q96L91 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005916 ! EP400_HUMAN [Term] id: CCO:B0011714 name: EP400_HUMAN-Phosphoserine1547 def: "Protein EP400_HUMAN with the residue 1547 substituted with Phosphoserine" [UniProtKB:Q96L91] xref: UniProtKB:Q96L91 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005916 ! EP400_HUMAN [Term] id: CCO:B0011715 name: EPAS1_HUMAN-4-hydroxyproline405 def: "Protein EPAS1_HUMAN with the residue 405 substituted with 4-hydroxyproline" [UniProtKB:Q99814] comment: By similarity xref: UniProtKB:Q99814 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006077 ! EPAS1_HUMAN [Term] id: CCO:B0011716 name: EPAS1_HUMAN-4-hydroxyproline531 def: "Protein EPAS1_HUMAN with the residue 531 substituted with 4-hydroxyproline" [UniProtKB:Q99814] comment: By similarity xref: UniProtKB:Q99814 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006077 ! EPAS1_HUMAN [Term] id: CCO:B0011717 name: EPAS1_HUMAN-Phosphothreonine840 def: "Protein EPAS1_HUMAN with the residue 840 substituted with Phosphothreonine" [UniProtKB:Q99814] comment: By similarity xref: UniProtKB:Q99814 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006077 ! EPAS1_HUMAN [Term] id: CCO:B0011718 name: EPAS1_HUMAN-3-hydroxyasparagine847 def: "Protein EPAS1_HUMAN with the residue 847 substituted with 3-hydroxyasparagine" [UniProtKB:Q99814] comment: By similarity xref: UniProtKB:Q99814 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006077 ! EPAS1_HUMAN [Term] id: CCO:B0011719 name: EPC1_HUMAN-Phosphoserine357 def: "Protein EPC1_HUMAN with the residue 357 substituted with Phosphoserine" [UniProtKB:Q9H2F5] xref: UniProtKB:Q9H2F5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005369 ! EPC1_HUMAN [Term] id: CCO:B0011720 name: EPHA2_HUMAN-Phosphoserine570 def: "Protein EPHA2_HUMAN with the residue 570 substituted with Phosphoserine" [UniProtKB:P29317] xref: UniProtKB:P29317 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005832 ! EPHA2_HUMAN [Term] id: CCO:B0011721 name: EPHA2_HUMAN-Phosphotyrosine588 def: "Protein EPHA2_HUMAN with the residue 588 substituted with Phosphotyrosine" [UniProtKB:P29317] comment: by autocatalysis; Potential xref: UniProtKB:P29317 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005832 ! EPHA2_HUMAN [Term] id: CCO:B0011722 name: EPHA2_HUMAN-Phosphotyrosine594 def: "Protein EPHA2_HUMAN with the residue 594 substituted with Phosphotyrosine" [UniProtKB:P29317] comment: by autocatalysis; xref: UniProtKB:P29317 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005832 ! EPHA2_HUMAN [Term] id: CCO:B0011723 name: EPHA2_HUMAN-Phosphotyrosine772 def: "Protein EPHA2_HUMAN with the residue 772 substituted with Phosphotyrosine" [UniProtKB:P29317] comment: by autocatalysis; xref: UniProtKB:P29317 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005832 ! EPHA2_HUMAN [Term] id: CCO:B0011724 name: EPHA2_HUMAN-Phosphoserine897 def: "Protein EPHA2_HUMAN with the residue 897 substituted with Phosphoserine" [UniProtKB:P29317] xref: UniProtKB:P29317 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005832 ! EPHA2_HUMAN [Term] id: CCO:B0011725 name: EPHA2_HUMAN-Phosphothreonine898 def: "Protein EPHA2_HUMAN with the residue 898 substituted with Phosphothreonine" [UniProtKB:P29317] xref: UniProtKB:P29317 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005832 ! EPHA2_HUMAN [Term] id: CCO:B0011726 name: EPHA2_HUMAN-Phosphoserine901 def: "Protein EPHA2_HUMAN with the residue 901 substituted with Phosphoserine" [UniProtKB:P29317] xref: UniProtKB:P29317 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005832 ! EPHA2_HUMAN [Term] id: CCO:B0011727 name: EPHA2_HUMAN-Phosphotyrosine921 def: "Protein EPHA2_HUMAN with the residue 921 substituted with Phosphotyrosine" [UniProtKB:P29317] comment: by autocatalysis; Potential xref: UniProtKB:P29317 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005832 ! EPHA2_HUMAN [Term] id: CCO:B0011728 name: EPHA2_HUMAN-Phosphotyrosine930 def: "Protein EPHA2_HUMAN with the residue 930 substituted with Phosphotyrosine" [UniProtKB:P29317] xref: UniProtKB:P29317 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005832 ! EPHA2_HUMAN [Term] id: CCO:B0011729 name: EPHB2_HUMAN-Phosphotyrosine596 def: "Protein EPHB2_HUMAN with the residue 596 substituted with Phosphotyrosine" [UniProtKB:P29323] comment: by autocatalysis; Potential xref: UniProtKB:P29323 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001568 ! EPHB2_HUMAN [Term] id: CCO:B0011730 name: EPHB2_HUMAN-Phosphotyrosine602 def: "Protein EPHB2_HUMAN with the residue 602 substituted with Phosphotyrosine" [UniProtKB:P29323] comment: by autocatalysis; Potential xref: UniProtKB:P29323 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001568 ! EPHB2_HUMAN [Term] id: CCO:B0011731 name: EPHB2_HUMAN-Phosphothreonine775 def: "Protein EPHB2_HUMAN with the residue 775 substituted with Phosphothreonine" [UniProtKB:P29323] xref: UniProtKB:P29323 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001568 ! EPHB2_HUMAN [Term] id: CCO:B0011732 name: EPHB2_HUMAN-Phosphotyrosine780 def: "Protein EPHB2_HUMAN with the residue 780 substituted with Phosphotyrosine" [UniProtKB:P29323] comment: by autocatalysis; Potential xref: UniProtKB:P29323 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001568 ! EPHB2_HUMAN [Term] id: CCO:B0011733 name: EPHB2_HUMAN-Phosphotyrosine930 def: "Protein EPHB2_HUMAN with the residue 930 substituted with Phosphotyrosine" [UniProtKB:P29323] comment: by autocatalysis; By similarity xref: UniProtKB:P29323 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001568 ! EPHB2_HUMAN [Term] id: CCO:B0011734 name: EPHB4_HUMAN-Phosphotyrosine590 def: "Protein EPHB4_HUMAN with the residue 590 substituted with Phosphotyrosine" [UniProtKB:P54760] comment: by autocatalysis; By similarity xref: UniProtKB:P54760 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005833 ! EPHB4_HUMAN [Term] id: CCO:B0011735 name: EPHB4_HUMAN-Phosphotyrosine596 def: "Protein EPHB4_HUMAN with the residue 596 substituted with Phosphotyrosine" [UniProtKB:P54760] comment: by autocatalysis; By similarity xref: UniProtKB:P54760 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005833 ! EPHB4_HUMAN [Term] id: CCO:B0011736 name: EPHB4_HUMAN-Phosphotyrosine774 def: "Protein EPHB4_HUMAN with the residue 774 substituted with Phosphotyrosine" [UniProtKB:P54760] comment: by autocatalysis; Potential xref: UniProtKB:P54760 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005833 ! EPHB4_HUMAN [Term] id: CCO:B0011737 name: EPHB4_HUMAN-Phosphotyrosine924 def: "Protein EPHB4_HUMAN with the residue 924 substituted with Phosphotyrosine" [UniProtKB:P54760] comment: by autocatalysis; By similarity xref: UniProtKB:P54760 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005833 ! EPHB4_HUMAN [Term] id: CCO:B0011738 name: ERBB2_HUMAN-Phosphotyrosine1139 def: "Protein ERBB2_HUMAN with the residue 1139 substituted with Phosphotyrosine" [UniProtKB:P04626] comment: by autocatalysis; By similarity xref: UniProtKB:P04626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005540 ! ERBB2_HUMAN [Term] id: CCO:B0011739 name: ERBB2_HUMAN-Phosphotyrosine1196 def: "Protein ERBB2_HUMAN with the residue 1196 substituted with Phosphotyrosine" [UniProtKB:P04626] comment: Potential xref: UniProtKB:P04626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005540 ! ERBB2_HUMAN [Term] id: CCO:B0011740 name: ERBB2_HUMAN-Phosphotyrosine1248 def: "Protein ERBB2_HUMAN with the residue 1248 substituted with Phosphotyrosine" [UniProtKB:P04626] comment: by autocatalysis; By similarity xref: UniProtKB:P04626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005540 ! ERBB2_HUMAN [Term] id: CCO:B0011741 name: ERBB4_HUMAN-Phosphotyrosine1162 def: "Protein ERBB4_HUMAN with the residue 1162 substituted with Phosphotyrosine" [UniProtKB:Q15303] comment: by autocatalysis; By similarity xref: UniProtKB:Q15303 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005906 ! ERBB4_HUMAN [Term] id: CCO:B0011742 name: ERBB4_HUMAN-Phosphotyrosine1188 def: "Protein ERBB4_HUMAN with the residue 1188 substituted with Phosphotyrosine" [UniProtKB:Q15303] comment: by autocatalysis; By similarity xref: UniProtKB:Q15303 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005906 ! ERBB4_HUMAN [Term] id: CCO:B0011743 name: ERBB4_HUMAN-Phosphotyrosine1258 def: "Protein ERBB4_HUMAN with the residue 1258 substituted with Phosphotyrosine" [UniProtKB:Q15303] comment: by autocatalysis; By similarity xref: UniProtKB:Q15303 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005906 ! ERBB4_HUMAN [Term] id: CCO:B0011744 name: ERBB4_HUMAN-Phosphotyrosine1284 def: "Protein ERBB4_HUMAN with the residue 1284 substituted with Phosphotyrosine" [UniProtKB:Q15303] comment: by autocatalysis; By similarity xref: UniProtKB:Q15303 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005906 ! ERBB4_HUMAN [Term] id: CCO:B0011745 name: ERCC5_HUMAN-Phosphoserine156 def: "Protein ERCC5_HUMAN with the residue 156 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011746 name: ERCC5_HUMAN-Phosphoserine157 def: "Protein ERCC5_HUMAN with the residue 157 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011747 name: ERCC5_HUMAN-Phosphothreonine338 def: "Protein ERCC5_HUMAN with the residue 338 substituted with Phosphothreonine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011748 name: ERCC5_HUMAN-Phosphoserine341 def: "Protein ERCC5_HUMAN with the residue 341 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011749 name: ERCC5_HUMAN-Phosphoserine355 def: "Protein ERCC5_HUMAN with the residue 355 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011750 name: ERCC5_HUMAN-Phosphoserine356 def: "Protein ERCC5_HUMAN with the residue 356 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011751 name: ERCC5_HUMAN-Phosphoserine357 def: "Protein ERCC5_HUMAN with the residue 357 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011752 name: ERCC5_HUMAN-Phosphoserine384 def: "Protein ERCC5_HUMAN with the residue 384 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011753 name: ERCC5_HUMAN-Phosphoserine428 def: "Protein ERCC5_HUMAN with the residue 428 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011754 name: ERCC5_HUMAN-Phosphoserine526 def: "Protein ERCC5_HUMAN with the residue 526 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011755 name: ERCC5_HUMAN-Phosphoserine563 def: "Protein ERCC5_HUMAN with the residue 563 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011756 name: ERCC5_HUMAN-Phosphoserine705 def: "Protein ERCC5_HUMAN with the residue 705 substituted with Phosphoserine" [UniProtKB:P28715] comment: By similarity xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011757 name: ERCC5_HUMAN-Phosphoserine724 def: "Protein ERCC5_HUMAN with the residue 724 substituted with Phosphoserine" [UniProtKB:P28715] xref: UniProtKB:P28715 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006036 ! ERCC5_HUMAN [Term] id: CCO:B0011764 name: ESCO1_HUMAN-Phosphoserine31 def: "Protein ESCO1_HUMAN with the residue 31 substituted with Phosphoserine" [UniProtKB:Q5FWF5] xref: UniProtKB:Q5FWF5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001848 ! ESCO1_HUMAN [Term] id: CCO:B0011765 name: ESCO2_HUMAN-Phosphoserine29 def: "Protein ESCO2_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:Q56NI9] xref: UniProtKB:Q56NI9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001841 ! ESCO2_HUMAN [Term] id: CCO:B0011766 name: ESPL1_HUMAN-Phosphoserine1126 def: "Protein ESPL1_HUMAN with the residue 1126 substituted with Phosphoserine" [UniProtKB:Q14674] xref: UniProtKB:Q14674 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001787 ! ESPL1_HUMAN [Term] id: CCO:B0011767 name: ESPL1_HUMAN-Phosphoserine1508 def: "Protein ESPL1_HUMAN with the residue 1508 substituted with Phosphoserine" [UniProtKB:Q14674] xref: UniProtKB:Q14674 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001783 ! peptidase activity relationship: has_function CCO:F0001784 ! cysteine-type peptidase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: transformation_of CCO:B0001787 ! ESPL1_HUMAN [Term] id: CCO:B0011768 name: ESR1_HUMAN-Phosphoserine104 def: "Protein ESR1_HUMAN with the residue 104 substituted with Phosphoserine" [UniProtKB:P03372] comment: by CDK2; xref: UniProtKB:P03372 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:B0011769 name: ESR1_HUMAN-Phosphoserine106 def: "Protein ESR1_HUMAN with the residue 106 substituted with Phosphoserine" [UniProtKB:P03372] comment: by CDK2; xref: UniProtKB:P03372 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:B0011770 name: ESR1_HUMAN-Phosphoserine118 def: "Protein ESR1_HUMAN with the residue 118 substituted with Phosphoserine" [UniProtKB:P03372] xref: UniProtKB:P03372 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:B0011771 name: ESR1_HUMAN-Phosphoserine167 def: "Protein ESR1_HUMAN with the residue 167 substituted with Phosphoserine" [UniProtKB:P03372] comment: by CK2; xref: UniProtKB:P03372 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:B0011772 name: ESR1_HUMAN-Phosphotyrosine537 def: "Protein ESR1_HUMAN with the residue 537 substituted with Phosphotyrosine" [UniProtKB:P03372] comment: by Tyr-kinases; xref: UniProtKB:P03372 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:B0011773 name: EVI5_HUMAN-Phosphoserine477 def: "Protein EVI5_HUMAN with the residue 477 substituted with Phosphoserine" [UniProtKB:O60447] xref: UniProtKB:O60447 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001408 ! EVI5_HUMAN [Term] id: CCO:B0011774 name: EVI5_HUMAN-Phosphoserine776 def: "Protein EVI5_HUMAN with the residue 776 substituted with Phosphoserine" [UniProtKB:O60447] comment: By similarity xref: UniProtKB:O60447 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001408 ! EVI5_HUMAN [Term] id: CCO:B0011775 name: EVI5_HUMAN-Phosphoserine778 def: "Protein EVI5_HUMAN with the residue 778 substituted with Phosphoserine" [UniProtKB:O60447] comment: By similarity xref: UniProtKB:O60447 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001408 ! EVI5_HUMAN [Term] id: CCO:B0011776 name: EWS_HUMAN-Phosphoserine266 def: "Protein EWS_HUMAN with the residue 266 substituted with Phosphoserine" [UniProtKB:Q01844] comment: by PKC; By similarity xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011777 name: EWS_HUMAN-Asymmetric dimethylarginine300 def: "Protein EWS_HUMAN with the residue 300 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011778 name: EWS_HUMAN-Asymmetric dimethylarginine302 def: "Protein EWS_HUMAN with the residue 302 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011779 name: EWS_HUMAN-Asymmetric dimethylarginine304 def: "Protein EWS_HUMAN with the residue 304 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011780 name: EWS_HUMAN-Asymmetric dimethylarginine309 def: "Protein EWS_HUMAN with the residue 309 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011781 name: EWS_HUMAN-Asymmetric dimethylarginine314 def: "Protein EWS_HUMAN with the residue 314 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011782 name: EWS_HUMAN-Asymmetric dimethylarginine317 def: "Protein EWS_HUMAN with the residue 317 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011783 name: EWS_HUMAN-Asymmetric dimethylarginine321 def: "Protein EWS_HUMAN with the residue 321 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011784 name: EWS_HUMAN-Asymmetric dimethylarginine455 def: "Protein EWS_HUMAN with the residue 455 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011785 name: EWS_HUMAN-Asymmetric dimethylarginine464 def: "Protein EWS_HUMAN with the residue 464 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011786 name: EWS_HUMAN-dimethylarginine471 def: "Protein EWS_HUMAN with the residue 471 substituted with dimethylarginine" [UniProtKB:Q01844] comment: alternate; xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011787 name: EWS_HUMAN-Omega-N-methylarginine471 def: "Protein EWS_HUMAN with the residue 471 substituted with Omega-N-methylarginine" [UniProtKB:Q01844] comment: alternate; xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011788 name: EWS_HUMAN-Asymmetric dimethylarginine490 def: "Protein EWS_HUMAN with the residue 490 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011789 name: EWS_HUMAN-Asymmetric dimethylarginine494 def: "Protein EWS_HUMAN with the residue 494 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011790 name: EWS_HUMAN-Asymmetric dimethylarginine500 def: "Protein EWS_HUMAN with the residue 500 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011791 name: EWS_HUMAN-Asymmetric dimethylarginine503 def: "Protein EWS_HUMAN with the residue 503 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011792 name: EWS_HUMAN-Asymmetric dimethylarginine506 def: "Protein EWS_HUMAN with the residue 506 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011793 name: EWS_HUMAN-Asymmetric dimethylarginine563 def: "Protein EWS_HUMAN with the residue 563 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011794 name: EWS_HUMAN-Asymmetric dimethylarginine565 def: "Protein EWS_HUMAN with the residue 565 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011795 name: EWS_HUMAN-Asymmetric dimethylarginine572 def: "Protein EWS_HUMAN with the residue 572 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011796 name: EWS_HUMAN-Asymmetric dimethylarginine575 def: "Protein EWS_HUMAN with the residue 575 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011797 name: EWS_HUMAN-Asymmetric dimethylarginine581 def: "Protein EWS_HUMAN with the residue 581 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011798 name: EWS_HUMAN-Asymmetric dimethylarginine589 def: "Protein EWS_HUMAN with the residue 589 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011799 name: EWS_HUMAN-Asymmetric dimethylarginine592 def: "Protein EWS_HUMAN with the residue 592 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011800 name: EWS_HUMAN-Asymmetric dimethylarginine596 def: "Protein EWS_HUMAN with the residue 596 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011801 name: EWS_HUMAN-Asymmetric dimethylarginine600 def: "Protein EWS_HUMAN with the residue 600 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011802 name: EWS_HUMAN-Asymmetric dimethylarginine603 def: "Protein EWS_HUMAN with the residue 603 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011803 name: EWS_HUMAN-Asymmetric dimethylarginine607 def: "Protein EWS_HUMAN with the residue 607 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011804 name: EWS_HUMAN-Asymmetric dimethylarginine615 def: "Protein EWS_HUMAN with the residue 615 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011805 name: EWS_HUMAN-Asymmetric dimethylarginine633 def: "Protein EWS_HUMAN with the residue 633 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011806 name: EWS_HUMAN-Asymmetric dimethylarginine636 def: "Protein EWS_HUMAN with the residue 636 substituted with Asymmetric dimethylarginine" [UniProtKB:Q01844] xref: UniProtKB:Q01844 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:B0011807 name: EXO1_HUMAN-Phosphoserine598 def: "Protein EXO1_HUMAN with the residue 598 substituted with Phosphoserine" [UniProtKB:Q9UQ84] xref: UniProtKB:Q9UQ84 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002240 ! EXO1_HUMAN [Term] id: CCO:B0011808 name: EXO1_HUMAN-Phosphoserine714 def: "Protein EXO1_HUMAN with the residue 714 substituted with Phosphoserine" [UniProtKB:Q9UQ84] xref: UniProtKB:Q9UQ84 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002240 ! EXO1_HUMAN [Term] id: CCO:B0011809 name: EXOC8_HUMAN-Phosphoserine19 def: "Protein EXOC8_HUMAN with the residue 19 substituted with Phosphoserine" [UniProtKB:Q8IYI6] xref: UniProtKB:Q8IYI6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005255 ! EXOC8_HUMAN [Term] id: CCO:B0011810 name: EXOS3_HUMAN-N-acetylalanine2 def: "Protein EXOS3_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9NQT5] xref: UniProtKB:Q9NQT5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005557 ! EXOS3_HUMAN [Term] id: CCO:B0011811 name: EXOS4_HUMAN-N-acetylalanine2 def: "Protein EXOS4_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9NPD3] xref: UniProtKB:Q9NPD3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005554 ! EXOS4_HUMAN [Term] id: CCO:B0011812 name: EXOS5_HUMAN-Phosphoserine20 def: "Protein EXOS5_HUMAN with the residue 20 substituted with Phosphoserine" [UniProtKB:Q9NQT4] xref: UniProtKB:Q9NQT4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005555 ! EXOS5_HUMAN [Term] id: CCO:B0011813 name: EXOS5_HUMAN-Phosphoserine27 def: "Protein EXOS5_HUMAN with the residue 27 substituted with Phosphoserine" [UniProtKB:Q9NQT4] comment: By similarity xref: UniProtKB:Q9NQT4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005555 ! EXOS5_HUMAN [Term] id: CCO:B0011814 name: FACD2_HUMAN-Phosphoserine167 def: "Protein FACD2_HUMAN with the residue 167 substituted with Phosphoserine" [UniProtKB:Q9BXW9] xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011815 name: FACD2_HUMAN-Phosphoserine178 def: "Protein FACD2_HUMAN with the residue 178 substituted with Phosphoserine" [UniProtKB:Q9BXW9] xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011816 name: FACD2_HUMAN-Phosphoserine222 def: "Protein FACD2_HUMAN with the residue 222 substituted with Phosphoserine" [UniProtKB:Q9BXW9] comment: by ATM; xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011817 name: FACD2_HUMAN-Phosphoserine592 def: "Protein FACD2_HUMAN with the residue 592 substituted with Phosphoserine" [UniProtKB:Q9BXW9] xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011818 name: FACD2_HUMAN-Phosphothreonine596 def: "Protein FACD2_HUMAN with the residue 596 substituted with Phosphothreonine" [UniProtKB:Q9BXW9] xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011819 name: FACD2_HUMAN-Phosphoserine717 def: "Protein FACD2_HUMAN with the residue 717 substituted with Phosphoserine" [UniProtKB:Q9BXW9] xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011820 name: FACD2_HUMAN-Phosphoserine1401 def: "Protein FACD2_HUMAN with the residue 1401 substituted with Phosphoserine" [UniProtKB:Q9BXW9] comment: by ATM; Probable xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011821 name: FACD2_HUMAN-Phosphoserine1404 def: "Protein FACD2_HUMAN with the residue 1404 substituted with Phosphoserine" [UniProtKB:Q9BXW9] comment: by ATM; xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011822 name: FACD2_HUMAN-Phosphoserine1412 def: "Protein FACD2_HUMAN with the residue 1412 substituted with Phosphoserine" [UniProtKB:Q9BXW9] xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011823 name: FACD2_HUMAN-Phosphoserine1418 def: "Protein FACD2_HUMAN with the residue 1418 substituted with Phosphoserine" [UniProtKB:Q9BXW9] xref: UniProtKB:Q9BXW9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:B0011824 name: FAK1_HUMAN-N-acetylalanine2 def: "Protein FAK1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q05397] xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011825 name: FAK1_HUMAN-Phosphotyrosine397 def: "Protein FAK1_HUMAN with the residue 397 substituted with Phosphotyrosine" [UniProtKB:Q05397] xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011826 name: FAK1_HUMAN-Phosphotyrosine407 def: "Protein FAK1_HUMAN with the residue 407 substituted with Phosphotyrosine" [UniProtKB:Q05397] xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011827 name: FAK1_HUMAN-Phosphotyrosine576 def: "Protein FAK1_HUMAN with the residue 576 substituted with Phosphotyrosine" [UniProtKB:Q05397] comment: by autocatalysis; xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011828 name: FAK1_HUMAN-Phosphotyrosine577 def: "Protein FAK1_HUMAN with the residue 577 substituted with Phosphotyrosine" [UniProtKB:Q05397] comment: by autocatalysis; xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011829 name: FAK1_HUMAN-Phosphoserine722 def: "Protein FAK1_HUMAN with the residue 722 substituted with Phosphoserine" [UniProtKB:Q05397] xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011830 name: FAK1_HUMAN-Phosphoserine840 def: "Protein FAK1_HUMAN with the residue 840 substituted with Phosphoserine" [UniProtKB:Q05397] xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011831 name: FAK1_HUMAN-Phosphoserine843 def: "Protein FAK1_HUMAN with the residue 843 substituted with Phosphoserine" [UniProtKB:Q05397] xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011832 name: FAK1_HUMAN-Phosphotyrosine861 def: "Protein FAK1_HUMAN with the residue 861 substituted with Phosphotyrosine" [UniProtKB:Q05397] xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011833 name: FAK1_HUMAN-Phosphoserine910 def: "Protein FAK1_HUMAN with the residue 910 substituted with Phosphoserine" [UniProtKB:Q05397] xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011834 name: FAK1_HUMAN-Phosphotyrosine925 def: "Protein FAK1_HUMAN with the residue 925 substituted with Phosphotyrosine" [UniProtKB:Q05397] xref: UniProtKB:Q05397 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005812 ! FAK1_HUMAN [Term] id: CCO:B0011835 name: FAK2_HUMAN-Phosphoserine375 def: "Protein FAK2_HUMAN with the residue 375 substituted with Phosphoserine" [UniProtKB:Q14289] xref: UniProtKB:Q14289 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005846 ! FAK2_HUMAN [Term] id: CCO:B0011836 name: FAK2_HUMAN-Phosphotyrosine402 def: "Protein FAK2_HUMAN with the residue 402 substituted with Phosphotyrosine" [UniProtKB:Q14289] xref: UniProtKB:Q14289 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005846 ! FAK2_HUMAN [Term] id: CCO:B0011837 name: FAK2_HUMAN-Phosphotyrosine579 def: "Protein FAK2_HUMAN with the residue 579 substituted with Phosphotyrosine" [UniProtKB:Q14289] comment: by autocatalysis; xref: UniProtKB:Q14289 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005846 ! FAK2_HUMAN [Term] id: CCO:B0011838 name: FAK2_HUMAN-Phosphotyrosine580 def: "Protein FAK2_HUMAN with the residue 580 substituted with Phosphotyrosine" [UniProtKB:Q14289] xref: UniProtKB:Q14289 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005846 ! FAK2_HUMAN [Term] id: CCO:B0011839 name: FAK2_HUMAN-Phosphotyrosine881 def: "Protein FAK2_HUMAN with the residue 881 substituted with Phosphotyrosine" [UniProtKB:Q14289] comment: By similarity xref: UniProtKB:Q14289 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005846 ! FAK2_HUMAN [Term] id: CCO:B0011840 name: FANCA_HUMAN-Phosphoserine849 def: "Protein FANCA_HUMAN with the residue 849 substituted with Phosphoserine" [UniProtKB:O15360] xref: UniProtKB:O15360 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005323 ! FANCA_HUMAN [Term] id: CCO:B0011841 name: FANCA_HUMAN-Phosphoserine850 def: "Protein FANCA_HUMAN with the residue 850 substituted with Phosphoserine" [UniProtKB:O15360] xref: UniProtKB:O15360 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005323 ! FANCA_HUMAN [Term] id: CCO:B0011842 name: FANCA_HUMAN-Phosphoserine858 def: "Protein FANCA_HUMAN with the residue 858 substituted with Phosphoserine" [UniProtKB:O15360] xref: UniProtKB:O15360 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005323 ! FANCA_HUMAN [Term] id: CCO:B0011843 name: FANCA_HUMAN-Phosphoserine1449 def: "Protein FANCA_HUMAN with the residue 1449 substituted with Phosphoserine" [UniProtKB:O15360] xref: UniProtKB:O15360 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005323 ! FANCA_HUMAN [Term] id: CCO:B0011844 name: FANCI_HUMAN-Phosphoserine407 def: "Protein FANCI_HUMAN with the residue 407 substituted with Phosphoserine" [UniProtKB:Q9NVI1] xref: UniProtKB:Q9NVI1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002170 ! FANCI_HUMAN [Term] id: CCO:B0011845 name: FANCI_HUMAN-Phosphoserine556 def: "Protein FANCI_HUMAN with the residue 556 substituted with Phosphoserine" [UniProtKB:Q9NVI1] comment: By similarity xref: UniProtKB:Q9NVI1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002170 ! FANCI_HUMAN [Term] id: CCO:B0011846 name: FANCI_HUMAN-Phosphoserine730 def: "Protein FANCI_HUMAN with the residue 730 substituted with Phosphoserine" [UniProtKB:Q9NVI1] xref: UniProtKB:Q9NVI1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002170 ! FANCI_HUMAN [Term] id: CCO:B0011847 name: FANCI_HUMAN-Phosphothreonine952 def: "Protein FANCI_HUMAN with the residue 952 substituted with Phosphothreonine" [UniProtKB:Q9NVI1] xref: UniProtKB:Q9NVI1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002170 ! FANCI_HUMAN [Term] id: CCO:B0011848 name: FANCI_HUMAN-Phosphoserine1121 def: "Protein FANCI_HUMAN with the residue 1121 substituted with Phosphoserine" [UniProtKB:Q9NVI1] xref: UniProtKB:Q9NVI1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002170 ! FANCI_HUMAN [Term] id: CCO:B0011849 name: FANCJ_HUMAN-Phosphoserine990 def: "Protein FANCJ_HUMAN with the residue 990 substituted with Phosphoserine" [UniProtKB:Q9BX63] xref: UniProtKB:Q9BX63 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002107 ! FANCJ_HUMAN [Term] id: CCO:B0011850 name: FANCJ_HUMAN-Phosphoserine1032 def: "Protein FANCJ_HUMAN with the residue 1032 substituted with Phosphoserine" [UniProtKB:Q9BX63] xref: UniProtKB:Q9BX63 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002107 ! FANCJ_HUMAN [Term] id: CCO:B0011866 name: FBX43_HUMAN-Phosphoserine76 def: "Protein FBX43_HUMAN with the residue 76 substituted with Phosphoserine" [UniProtKB:Q4G163] comment: Probable xref: UniProtKB:Q4G163 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001835 ! FBX43_HUMAN [Term] id: CCO:B0011867 name: FBX43_HUMAN-Phosphothreonine234 def: "Protein FBX43_HUMAN with the residue 234 substituted with Phosphothreonine" [UniProtKB:Q4G163] xref: UniProtKB:Q4G163 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001835 ! FBX43_HUMAN [Term] id: CCO:B0011868 name: FBX43_HUMAN-Phosphoserine334 def: "Protein FBX43_HUMAN with the residue 334 substituted with Phosphoserine" [UniProtKB:Q4G163] comment: Probable xref: UniProtKB:Q4G163 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001835 ! FBX43_HUMAN [Term] id: CCO:B0011869 name: FBX43_HUMAN-Phosphotyrosine503 def: "Protein FBX43_HUMAN with the residue 503 substituted with Phosphotyrosine" [UniProtKB:Q4G163] comment: By similarity xref: UniProtKB:Q4G163 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001835 ! FBX43_HUMAN [Term] id: CCO:B0011870 name: FBX4_HUMAN-Phosphoserine12 def: "Protein FBX4_HUMAN with the residue 12 substituted with Phosphoserine" [UniProtKB:Q9UKT5] xref: UniProtKB:Q9UKT5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005441 ! FBX4_HUMAN [Term] id: CCO:B0011871 name: FBX4_HUMAN-Phosphoserine238 def: "Protein FBX4_HUMAN with the residue 238 substituted with Phosphoserine" [UniProtKB:Q9UKT5] xref: UniProtKB:Q9UKT5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005441 ! FBX4_HUMAN [Term] id: CCO:B0011872 name: FBX4_HUMAN-Phosphothreonine239 def: "Protein FBX4_HUMAN with the residue 239 substituted with Phosphothreonine" [UniProtKB:Q9UKT5] xref: UniProtKB:Q9UKT5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005441 ! FBX4_HUMAN [Term] id: CCO:B0011873 name: FBX4_HUMAN-Phosphothreonine240 def: "Protein FBX4_HUMAN with the residue 240 substituted with Phosphothreonine" [UniProtKB:Q9UKT5] xref: UniProtKB:Q9UKT5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005441 ! FBX4_HUMAN [Term] id: CCO:B0011874 name: FBXW7_HUMAN-Phosphoserine26 def: "Protein FBXW7_HUMAN with the residue 26 substituted with Phosphoserine" [UniProtKB:Q969H0] xref: UniProtKB:Q969H0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005654 ! FBXW7_HUMAN [Term] id: CCO:B0011875 name: FEZ1_HUMAN-Phosphoserine58 def: "Protein FEZ1_HUMAN with the residue 58 substituted with Phosphoserine" [UniProtKB:Q99689] comment: By similarity xref: UniProtKB:Q99689 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005393 ! FEZ1_HUMAN [Term] id: CCO:B0011880 name: FGFR3_HUMAN-Phosphotyrosine648 def: "Protein FGFR3_HUMAN with the residue 648 substituted with Phosphotyrosine" [UniProtKB:P22607] comment: by autocatalysis; By similarity xref: UniProtKB:P22607 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005920 ! FGFR3_HUMAN [Term] id: CCO:B0011881 name: FHIT_HUMAN-Phosphotyrosine114 def: "Protein FHIT_HUMAN with the residue 114 substituted with Phosphotyrosine" [UniProtKB:P49789] comment: by SRC; xref: UniProtKB:P49789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001636 ! FHIT_HUMAN [Term] id: CCO:B0011882 name: FHIT_HUMAN-Phosphotyrosine145 def: "Protein FHIT_HUMAN with the residue 145 substituted with Phosphotyrosine" [UniProtKB:P49789] xref: UniProtKB:P49789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_function CCO:F0007012 ! bis(5'-adenosyl)-triphosphatase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001636 ! FHIT_HUMAN [Term] id: CCO:B0011883 name: FL2D_HUMAN-Phosphoserine244 def: "Protein FL2D_HUMAN with the residue 244 substituted with Phosphoserine" [UniProtKB:Q15007] xref: UniProtKB:Q15007 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001798 ! FL2D_HUMAN [Term] id: CCO:B0011884 name: FL2D_HUMAN-Phosphoserine306 def: "Protein FL2D_HUMAN with the residue 306 substituted with Phosphoserine" [UniProtKB:Q15007] xref: UniProtKB:Q15007 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001798 ! FL2D_HUMAN [Term] id: CCO:B0011885 name: FNBP1_HUMAN-Phosphothreonine294 def: "Protein FNBP1_HUMAN with the residue 294 substituted with Phosphothreonine" [UniProtKB:Q96RU3] xref: UniProtKB:Q96RU3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005386 ! FNBP1_HUMAN [Term] id: CCO:B0011886 name: FNBP1_HUMAN-Phosphoserine296 def: "Protein FNBP1_HUMAN with the residue 296 substituted with Phosphoserine" [UniProtKB:Q96RU3] xref: UniProtKB:Q96RU3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005386 ! FNBP1_HUMAN [Term] id: CCO:B0011887 name: FNBP1_HUMAN-Phosphoserine299 def: "Protein FNBP1_HUMAN with the residue 299 substituted with Phosphoserine" [UniProtKB:Q96RU3] xref: UniProtKB:Q96RU3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005386 ! FNBP1_HUMAN [Term] id: CCO:B0011888 name: FNBP1_HUMAN-Phosphotyrosine522 def: "Protein FNBP1_HUMAN with the residue 522 substituted with Phosphotyrosine" [UniProtKB:Q96RU3] xref: UniProtKB:Q96RU3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005386 ! FNBP1_HUMAN [Term] id: CCO:B0011889 name: FOXN3_HUMAN-Phosphoserine85 def: "Protein FOXN3_HUMAN with the residue 85 substituted with Phosphoserine" [UniProtKB:O00409] comment: By similarity xref: UniProtKB:O00409 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0003206 ! transcription repressor activity relationship: has_function CCO:F0005877 ! sequence-specific DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: transformation_of CCO:B0001347 ! FOXN3_HUMAN [Term] id: CCO:B0011890 name: FOXO4_HUMAN-Phosphothreonine32 def: "Protein FOXO4_HUMAN with the residue 32 substituted with Phosphothreonine" [UniProtKB:P98177] comment: by PKB/AKT1; xref: UniProtKB:P98177 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001706 ! FOXO4_HUMAN [Term] id: CCO:B0011891 name: FOXO4_HUMAN-Phosphoserine197 def: "Protein FOXO4_HUMAN with the residue 197 substituted with Phosphoserine" [UniProtKB:P98177] comment: by PKB/AKT1; xref: UniProtKB:P98177 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001706 ! FOXO4_HUMAN [Term] id: CCO:B0011892 name: FOXO4_HUMAN-Phosphoserine262 def: "Protein FOXO4_HUMAN with the residue 262 substituted with Phosphoserine" [UniProtKB:P98177] comment: by PKB/AKT1; xref: UniProtKB:P98177 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001706 ! FOXO4_HUMAN [Term] id: CCO:B0011895 name: FRIL_HUMAN-N-acetylserine2 def: "Protein FRIL_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P02792] xref: UniProtKB:P02792 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006192 ! FRIL_HUMAN [Term] id: CCO:B0011898 name: FRMD6_HUMAN-Phosphoserine522 def: "Protein FRMD6_HUMAN with the residue 522 substituted with Phosphoserine" [UniProtKB:Q96NE9] comment: By similarity xref: UniProtKB:Q96NE9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005267 ! FRMD6_HUMAN [Term] id: CCO:B0011899 name: FRMD6_HUMAN-Phosphoserine525 def: "Protein FRMD6_HUMAN with the residue 525 substituted with Phosphoserine" [UniProtKB:Q96NE9] comment: By similarity xref: UniProtKB:Q96NE9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005267 ! FRMD6_HUMAN [Term] id: CCO:B0011900 name: FUMH_HUMAN-N6-acetyllysine66 def: "Protein FUMH_HUMAN with the residue 66 substituted with N6-acetyllysine" [UniProtKB:P07954] comment: By similarity xref: UniProtKB:P07954 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001496 ! FUMH_HUMAN [Term] id: CCO:B0011901 name: FUMH_HUMAN-N6-acetyllysine115 def: "Protein FUMH_HUMAN with the residue 115 substituted with N6-acetyllysine" [UniProtKB:P07954] comment: By similarity xref: UniProtKB:P07954 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001496 ! FUMH_HUMAN [Term] id: CCO:B0011902 name: FUMH_HUMAN-N6-acetyllysine477 def: "Protein FUMH_HUMAN with the residue 477 substituted with N6-acetyllysine" [UniProtKB:P07954] comment: By similarity xref: UniProtKB:P07954 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001496 ! FUMH_HUMAN [Term] id: CCO:B0011903 name: FXR1_HUMAN-Phosphoserine406 def: "Protein FXR1_HUMAN with the residue 406 substituted with Phosphoserine" [UniProtKB:P51114] comment: By similarity xref: UniProtKB:P51114 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006140 ! FXR1_HUMAN [Term] id: CCO:B0011904 name: FXR1_HUMAN-Phosphoserine409 def: "Protein FXR1_HUMAN with the residue 409 substituted with Phosphoserine" [UniProtKB:P51114] xref: UniProtKB:P51114 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006140 ! FXR1_HUMAN [Term] id: CCO:B0011905 name: FXR1_HUMAN-Omega-N-methylated arginine445 def: "Protein FXR1_HUMAN with the residue 445 substituted with Omega-N-methylated arginine" [UniProtKB:P51114] xref: UniProtKB:P51114 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006140 ! FXR1_HUMAN [Term] id: CCO:B0011906 name: FXR1_HUMAN-Phosphotyrosine477 def: "Protein FXR1_HUMAN with the residue 477 substituted with Phosphotyrosine" [UniProtKB:P51114] xref: UniProtKB:P51114 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006140 ! FXR1_HUMAN [Term] id: CCO:B0011907 name: FYN_HUMAN-Phosphothreonine12 def: "Protein FYN_HUMAN with the residue 12 substituted with Phosphothreonine" [UniProtKB:P06241] comment: by PKC; By similarity xref: UniProtKB:P06241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005609 ! FYN_HUMAN [Term] id: CCO:B0011908 name: FYN_HUMAN-Phosphoserine21 def: "Protein FYN_HUMAN with the residue 21 substituted with Phosphoserine" [UniProtKB:P06241] xref: UniProtKB:P06241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005609 ! FYN_HUMAN [Term] id: CCO:B0011909 name: FYN_HUMAN-Phosphotyrosine420 def: "Protein FYN_HUMAN with the residue 420 substituted with Phosphotyrosine" [UniProtKB:P06241] comment: by autocatalysis; xref: UniProtKB:P06241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005609 ! FYN_HUMAN [Term] id: CCO:B0011910 name: FYN_HUMAN-Phosphotyrosine531 def: "Protein FYN_HUMAN with the residue 531 substituted with Phosphotyrosine" [UniProtKB:P06241] xref: UniProtKB:P06241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005609 ! FYN_HUMAN [Term] id: CCO:B0011911 name: FZR_HUMAN-Phosphoserine36 def: "Protein FZR_HUMAN with the residue 36 substituted with Phosphoserine" [UniProtKB:Q9UM11] comment: By similarity xref: UniProtKB:Q9UM11 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002229 ! FZR_HUMAN [Term] id: CCO:B0011912 name: FZR_HUMAN-Phosphoserine151 def: "Protein FZR_HUMAN with the residue 151 substituted with Phosphoserine" [UniProtKB:Q9UM11] comment: By similarity xref: UniProtKB:Q9UM11 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002229 ! FZR_HUMAN [Term] id: CCO:B0011913 name: G3P_HUMAN-Phosphotyrosine42 def: "Protein G3P_HUMAN with the residue 42 substituted with Phosphotyrosine" [UniProtKB:P04406] xref: UniProtKB:P04406 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005458 ! G3P_HUMAN [Term] id: CCO:B0011914 name: G3P_HUMAN-Phosphoserine83 def: "Protein G3P_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:P04406] xref: UniProtKB:P04406 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005458 ! G3P_HUMAN [Term] id: CCO:B0011915 name: G3P_HUMAN-Phosphothreonine211 def: "Protein G3P_HUMAN with the residue 211 substituted with Phosphothreonine" [UniProtKB:P04406] comment: By similarity xref: UniProtKB:P04406 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005458 ! G3P_HUMAN [Term] id: CCO:B0011916 name: GA2L1_HUMAN-Phosphoserine384 def: "Protein GA2L1_HUMAN with the residue 384 substituted with Phosphoserine" [UniProtKB:Q99501] xref: UniProtKB:Q99501 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002067 ! GA2L1_HUMAN [Term] id: CCO:B0011917 name: GAB2_HUMAN-Phosphotyrosine266 def: "Protein GAB2_HUMAN with the residue 266 substituted with Phosphotyrosine" [UniProtKB:Q9UQC2] xref: UniProtKB:Q9UQC2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005924 ! GAB2_HUMAN [Term] id: CCO:B0011918 name: GAB2_HUMAN-Phosphoserine405 def: "Protein GAB2_HUMAN with the residue 405 substituted with Phosphoserine" [UniProtKB:Q9UQC2] comment: By similarity xref: UniProtKB:Q9UQC2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005924 ! GAB2_HUMAN [Term] id: CCO:B0011919 name: GABR1_HUMAN-Phosphothreonine930 def: "Protein GABR1_HUMAN with the residue 930 substituted with Phosphothreonine" [UniProtKB:Q9UBS5] comment: By similarity xref: UniProtKB:Q9UBS5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006317 ! GABR1_HUMAN [Term] id: CCO:B0011920 name: GAK_HUMAN-Phosphoserine829 def: "Protein GAK_HUMAN with the residue 829 substituted with Phosphoserine" [UniProtKB:O14976] comment: By similarity xref: UniProtKB:O14976 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001364 ! GAK_HUMAN [Term] id: CCO:B0011923 name: GBLP_HUMAN-N-acetylthreonine2 def: "Protein GBLP_HUMAN with the residue 2 substituted with N-acetylthreonine" [UniProtKB:P63244] xref: UniProtKB:P63244 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005739 ! GBLP_HUMAN [Term] id: CCO:B0011924 name: GBLP_HUMAN-Phosphotyrosine228 def: "Protein GBLP_HUMAN with the residue 228 substituted with Phosphotyrosine" [UniProtKB:P63244] xref: UniProtKB:P63244 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005739 ! GBLP_HUMAN [Term] id: CCO:B0011925 name: GCNL2_HUMAN-Phosphotyrosine734 def: "Protein GCNL2_HUMAN with the residue 734 substituted with Phosphotyrosine" [UniProtKB:Q92830] xref: UniProtKB:Q92830 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005647 ! GCNL2_HUMAN [Term] id: CCO:B0011928 name: GEMI_HUMAN-Phosphoserine64 def: "Protein GEMI_HUMAN with the residue 64 substituted with Phosphoserine" [UniProtKB:O75496] xref: UniProtKB:O75496 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001432 ! GEMI_HUMAN [Term] id: CCO:B0011929 name: GFI1B_HUMAN-Phosphoserine261 def: "Protein GFI1B_HUMAN with the residue 261 substituted with Phosphoserine" [UniProtKB:Q5VTD9] xref: UniProtKB:Q5VTD9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001898 ! GFI1B_HUMAN [Term] id: CCO:B0011932 name: GIT1_HUMAN-Phosphoserine134 def: "Protein GIT1_HUMAN with the residue 134 substituted with Phosphoserine" [UniProtKB:Q9Y2X7] xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0011933 name: GIT1_HUMAN-Phosphoserine361 def: "Protein GIT1_HUMAN with the residue 361 substituted with Phosphoserine" [UniProtKB:Q9Y2X7] comment: By similarity xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0011934 name: GIT1_HUMAN-Phosphoserine362 def: "Protein GIT1_HUMAN with the residue 362 substituted with Phosphoserine" [UniProtKB:Q9Y2X7] comment: By similarity xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0011935 name: GIT1_HUMAN-Phosphoserine385 def: "Protein GIT1_HUMAN with the residue 385 substituted with Phosphoserine" [UniProtKB:Q9Y2X7] xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0011936 name: GIT1_HUMAN-Phosphoserine388 def: "Protein GIT1_HUMAN with the residue 388 substituted with Phosphoserine" [UniProtKB:Q9Y2X7] xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0011937 name: GIT1_HUMAN-Phosphotyrosine545 def: "Protein GIT1_HUMAN with the residue 545 substituted with Phosphotyrosine" [UniProtKB:Q9Y2X7] xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0011938 name: GIT1_HUMAN-Phosphotyrosine554 def: "Protein GIT1_HUMAN with the residue 554 substituted with Phosphotyrosine" [UniProtKB:Q9Y2X7] xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0011939 name: GIT1_HUMAN-Phosphoserine592 def: "Protein GIT1_HUMAN with the residue 592 substituted with Phosphoserine" [UniProtKB:Q9Y2X7] xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0011940 name: GIT1_HUMAN-Phosphotyrosine598 def: "Protein GIT1_HUMAN with the residue 598 substituted with Phosphotyrosine" [UniProtKB:Q9Y2X7] xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0011941 name: GLI3_HUMAN-Phosphoserine19 def: "Protein GLI3_HUMAN with the residue 19 substituted with Phosphoserine" [UniProtKB:P10071] xref: UniProtKB:P10071 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005850 ! GLI3_HUMAN [Term] id: CCO:B0011942 name: GLU2B_HUMAN-Phosphoserine89 def: "Protein GLU2B_HUMAN with the residue 89 substituted with Phosphoserine" [UniProtKB:P14314] comment: by PKC; Potential xref: UniProtKB:P14314 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006228 ! GLU2B_HUMAN [Term] id: CCO:B0011943 name: GLU2B_HUMAN-Phosphoserine383 def: "Protein GLU2B_HUMAN with the residue 383 substituted with Phosphoserine" [UniProtKB:P14314] comment: by PKC; Potential xref: UniProtKB:P14314 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006228 ! GLU2B_HUMAN [Term] id: CCO:B0011944 name: GLU2B_HUMAN-Phosphoserine390 def: "Protein GLU2B_HUMAN with the residue 390 substituted with Phosphoserine" [UniProtKB:P14314] comment: by PKC; Potential xref: UniProtKB:P14314 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006228 ! GLU2B_HUMAN [Term] id: CCO:B0011945 name: GLU2B_HUMAN-Phosphoserine434 def: "Protein GLU2B_HUMAN with the residue 434 substituted with Phosphoserine" [UniProtKB:P14314] comment: by PKC; Potential xref: UniProtKB:P14314 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006228 ! GLU2B_HUMAN [Term] id: CCO:B0011947 name: GLYC_HUMAN-Phosphotyrosine34 def: "Protein GLYC_HUMAN with the residue 34 substituted with Phosphotyrosine" [UniProtKB:P34896] comment: By similarity xref: UniProtKB:P34896 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006184 ! GLYC_HUMAN [Term] id: CCO:B0011949 name: GNAI1_HUMAN-ADP-ribosylarginine178 def: "Protein GNAI1_HUMAN with the residue 178 substituted with ADP-ribosylarginine" [UniProtKB:P63096] comment: by cholera toxin; By similarity xref: UniProtKB:P63096 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005493 ! GNAI1_HUMAN [Term] id: CCO:B0011950 name: GNAI1_HUMAN-ADP-ribosylcysteine351 def: "Protein GNAI1_HUMAN with the residue 351 substituted with ADP-ribosylcysteine" [UniProtKB:P63096] comment: by pertussis toxin; By similarity xref: UniProtKB:P63096 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005493 ! GNAI1_HUMAN [Term] id: CCO:B0011951 name: GNAI2_HUMAN-ADP-ribosylarginine179 def: "Protein GNAI2_HUMAN with the residue 179 substituted with ADP-ribosylarginine" [UniProtKB:P04899] comment: by cholera toxin; By similarity xref: UniProtKB:P04899 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005754 ! GNAI2_HUMAN [Term] id: CCO:B0011952 name: GNAI2_HUMAN-ADP-ribosylcysteine352 def: "Protein GNAI2_HUMAN with the residue 352 substituted with ADP-ribosylcysteine" [UniProtKB:P04899] comment: by pertussis toxin; By similarity xref: UniProtKB:P04899 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005754 ! GNAI2_HUMAN [Term] id: CCO:B0011954 name: GOGA2_HUMAN-Phosphoserine8 def: "Protein GOGA2_HUMAN with the residue 8 substituted with Phosphoserine" [UniProtKB:Q08379] xref: UniProtKB:Q08379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006274 ! GOGA2_HUMAN [Term] id: CCO:B0011955 name: GOGA2_HUMAN-Phosphoserine25 def: "Protein GOGA2_HUMAN with the residue 25 substituted with Phosphoserine" [UniProtKB:Q08379] xref: UniProtKB:Q08379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006274 ! GOGA2_HUMAN [Term] id: CCO:B0011956 name: GOGA2_HUMAN-Phosphoserine111 def: "Protein GOGA2_HUMAN with the residue 111 substituted with Phosphoserine" [UniProtKB:Q08379] comment: By similarity xref: UniProtKB:Q08379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006274 ! GOGA2_HUMAN [Term] id: CCO:B0011957 name: GORS2_HUMAN-Omega-N-methylated arginine30 def: "Protein GORS2_HUMAN with the residue 30 substituted with Omega-N-methylated arginine" [UniProtKB:Q9H8Y8] comment: By similarity xref: UniProtKB:Q9H8Y8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:B0011958 name: GORS2_HUMAN-Omega-N-methylated arginine47 def: "Protein GORS2_HUMAN with the residue 47 substituted with Omega-N-methylated arginine" [UniProtKB:Q9H8Y8] comment: By similarity xref: UniProtKB:Q9H8Y8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:B0011959 name: GORS2_HUMAN-Phosphoserine214 def: "Protein GORS2_HUMAN with the residue 214 substituted with Phosphoserine" [UniProtKB:Q9H8Y8] xref: UniProtKB:Q9H8Y8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:B0011960 name: GORS2_HUMAN-Phosphothreonine222 def: "Protein GORS2_HUMAN with the residue 222 substituted with Phosphothreonine" [UniProtKB:Q9H8Y8] xref: UniProtKB:Q9H8Y8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:B0011961 name: GORS2_HUMAN-Phosphothreonine225 def: "Protein GORS2_HUMAN with the residue 225 substituted with Phosphothreonine" [UniProtKB:Q9H8Y8] xref: UniProtKB:Q9H8Y8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:B0011962 name: GORS2_HUMAN-Phosphoserine409 def: "Protein GORS2_HUMAN with the residue 409 substituted with Phosphoserine" [UniProtKB:Q9H8Y8] comment: By similarity xref: UniProtKB:Q9H8Y8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:B0011963 name: GORS2_HUMAN-Phosphothreonine415 def: "Protein GORS2_HUMAN with the residue 415 substituted with Phosphothreonine" [UniProtKB:Q9H8Y8] xref: UniProtKB:Q9H8Y8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:B0011964 name: GORS2_HUMAN-Phosphoserine451 def: "Protein GORS2_HUMAN with the residue 451 substituted with Phosphoserine" [UniProtKB:Q9H8Y8] xref: UniProtKB:Q9H8Y8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:B0011968 name: GPSM2_HUMAN-Phosphoserine125 def: "Protein GPSM2_HUMAN with the residue 125 substituted with Phosphoserine" [UniProtKB:P81274] comment: by PKG; Potential xref: UniProtKB:P81274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:B0011969 name: GPSM2_HUMAN-Phosphoserine345 def: "Protein GPSM2_HUMAN with the residue 345 substituted with Phosphoserine" [UniProtKB:P81274] comment: by PKG; Potential xref: UniProtKB:P81274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:B0011970 name: GPSM2_HUMAN-Phosphoserine401 def: "Protein GPSM2_HUMAN with the residue 401 substituted with Phosphoserine" [UniProtKB:P81274] comment: by PKA; Potential xref: UniProtKB:P81274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:B0011971 name: GPSM2_HUMAN-Phosphoserine494 def: "Protein GPSM2_HUMAN with the residue 494 substituted with Phosphoserine" [UniProtKB:P81274] comment: by PKC; Potential xref: UniProtKB:P81274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:B0011972 name: GPSM2_HUMAN-Phosphoserine600 def: "Protein GPSM2_HUMAN with the residue 600 substituted with Phosphoserine" [UniProtKB:P81274] comment: by PKG; Potential xref: UniProtKB:P81274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:B0011973 name: GRB2_HUMAN-Phosphotyrosine160 def: "Protein GRB2_HUMAN with the residue 160 substituted with Phosphotyrosine" [UniProtKB:P62993] xref: UniProtKB:P62993 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005454 ! GRB2_HUMAN [Term] id: CCO:B0011974 name: GRB2_HUMAN-Phosphotyrosine209 def: "Protein GRB2_HUMAN with the residue 209 substituted with Phosphotyrosine" [UniProtKB:P62993] xref: UniProtKB:P62993 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005454 ! GRB2_HUMAN [Term] id: CCO:B0011975 name: GRLF1_HUMAN-Phosphothreonine685 def: "Protein GRLF1_HUMAN with the residue 685 substituted with Phosphothreonine" [UniProtKB:Q9NRY4] xref: UniProtKB:Q9NRY4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002160 ! GRLF1_HUMAN [Term] id: CCO:B0011976 name: GRLF1_HUMAN-Phosphoserine773 def: "Protein GRLF1_HUMAN with the residue 773 substituted with Phosphoserine" [UniProtKB:Q9NRY4] comment: By similarity xref: UniProtKB:Q9NRY4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002160 ! GRLF1_HUMAN [Term] id: CCO:B0011977 name: GRLF1_HUMAN-Phosphoserine980 def: "Protein GRLF1_HUMAN with the residue 980 substituted with Phosphoserine" [UniProtKB:Q9NRY4] comment: By similarity xref: UniProtKB:Q9NRY4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002160 ! GRLF1_HUMAN [Term] id: CCO:B0011978 name: GRLF1_HUMAN-Phosphotyrosine1105 def: "Protein GRLF1_HUMAN with the residue 1105 substituted with Phosphotyrosine" [UniProtKB:Q9NRY4] xref: UniProtKB:Q9NRY4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002160 ! GRLF1_HUMAN [Term] id: CCO:B0011979 name: GRLF1_HUMAN-Phosphoserine1134 def: "Protein GRLF1_HUMAN with the residue 1134 substituted with Phosphoserine" [UniProtKB:Q9NRY4] xref: UniProtKB:Q9NRY4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002160 ! GRLF1_HUMAN [Term] id: CCO:B0011980 name: GRLF1_HUMAN-Phosphoserine1179 def: "Protein GRLF1_HUMAN with the residue 1179 substituted with Phosphoserine" [UniProtKB:Q9NRY4] xref: UniProtKB:Q9NRY4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000301 ! transcription corepressor activity relationship: has_function CCO:F0001401 ! GTPase activator activity relationship: has_function CCO:F0001656 ! GTP binding relationship: has_function CCO:F0003206 ! transcription repressor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0002160 ! GRLF1_HUMAN [Term] id: CCO:B0011981 name: GRLF1_HUMAN-Phosphoserine1195 def: "Protein GRLF1_HUMAN with the residue 1195 substituted with Phosphoserine" [UniProtKB:Q9NRY4] xref: UniProtKB:Q9NRY4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002160 ! GRLF1_HUMAN [Term] id: CCO:B0011982 name: GRP75_HUMAN-Phosphoserine200 def: "Protein GRP75_HUMAN with the residue 200 substituted with Phosphoserine" [UniProtKB:P38646] xref: UniProtKB:P38646 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005828 ! GRP75_HUMAN [Term] id: CCO:B0011983 name: GRP75_HUMAN-N6-acetyllysine288 def: "Protein GRP75_HUMAN with the residue 288 substituted with N6-acetyllysine" [UniProtKB:P38646] comment: By similarity xref: UniProtKB:P38646 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005828 ! GRP75_HUMAN [Term] id: CCO:B0011984 name: GRP75_HUMAN-N6-acetyllysine300 def: "Protein GRP75_HUMAN with the residue 300 substituted with N6-acetyllysine" [UniProtKB:P38646] comment: By similarity xref: UniProtKB:P38646 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005828 ! GRP75_HUMAN [Term] id: CCO:B0011985 name: GRP78_HUMAN-Phosphothreonine166 def: "Protein GRP78_HUMAN with the residue 166 substituted with Phosphothreonine" [UniProtKB:P11021] comment: By similarity xref: UniProtKB:P11021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005843 ! GRP78_HUMAN [Term] id: CCO:B0011986 name: GRP78_HUMAN-Phosphotyrosine466 def: "Protein GRP78_HUMAN with the residue 466 substituted with Phosphotyrosine" [UniProtKB:P11021] xref: UniProtKB:P11021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005843 ! GRP78_HUMAN [Term] id: CCO:B0011987 name: GRP78_HUMAN-Phosphoserine571 def: "Protein GRP78_HUMAN with the residue 571 substituted with Phosphoserine" [UniProtKB:P11021] comment: By similarity xref: UniProtKB:P11021 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005843 ! GRP78_HUMAN [Term] id: CCO:B0011988 name: GRWD1_HUMAN-Phosphoserine119 def: "Protein GRWD1_HUMAN with the residue 119 substituted with Phosphoserine" [UniProtKB:Q9BQ67] xref: UniProtKB:Q9BQ67 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005687 ! GRWD1_HUMAN [Term] id: CCO:B0011989 name: GRWD1_HUMAN-Phosphoserine122 def: "Protein GRWD1_HUMAN with the residue 122 substituted with Phosphoserine" [UniProtKB:Q9BQ67] xref: UniProtKB:Q9BQ67 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005687 ! GRWD1_HUMAN [Term] id: CCO:B0011990 name: GTSE1_HUMAN-Phosphoserine168 def: "Protein GTSE1_HUMAN with the residue 168 substituted with Phosphoserine" [UniProtKB:Q9NYZ3] xref: UniProtKB:Q9NYZ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:B0011991 name: GTSE1_HUMAN-Phosphoserine494 def: "Protein GTSE1_HUMAN with the residue 494 substituted with Phosphoserine" [UniProtKB:Q9NYZ3] xref: UniProtKB:Q9NYZ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:B0011992 name: GTSE1_HUMAN-Phosphoserine495 def: "Protein GTSE1_HUMAN with the residue 495 substituted with Phosphoserine" [UniProtKB:Q9NYZ3] xref: UniProtKB:Q9NYZ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:B0011993 name: GTSE1_HUMAN-Phosphoserine501 def: "Protein GTSE1_HUMAN with the residue 501 substituted with Phosphoserine" [UniProtKB:Q9NYZ3] xref: UniProtKB:Q9NYZ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:B0011994 name: GTSE1_HUMAN-Phosphoserine504 def: "Protein GTSE1_HUMAN with the residue 504 substituted with Phosphoserine" [UniProtKB:Q9NYZ3] xref: UniProtKB:Q9NYZ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:B0011995 name: GTSE1_HUMAN-Phosphoserine536 def: "Protein GTSE1_HUMAN with the residue 536 substituted with Phosphoserine" [UniProtKB:Q9NYZ3] xref: UniProtKB:Q9NYZ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:B0011996 name: GTSE1_HUMAN-Phosphoserine575 def: "Protein GTSE1_HUMAN with the residue 575 substituted with Phosphoserine" [UniProtKB:Q9NYZ3] xref: UniProtKB:Q9NYZ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:B0011997 name: GTSE1_HUMAN-Phosphoserine580 def: "Protein GTSE1_HUMAN with the residue 580 substituted with Phosphoserine" [UniProtKB:Q9NYZ3] xref: UniProtKB:Q9NYZ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:B0011998 name: GTSE1_HUMAN-Phosphoserine592 def: "Protein GTSE1_HUMAN with the residue 592 substituted with Phosphoserine" [UniProtKB:Q9NYZ3] xref: UniProtKB:Q9NYZ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:B0011999 name: H11_HUMAN-N-acetylserine2 def: "Protein H11_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:Q02539] comment: By similarity xref: UniProtKB:Q02539 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005863 ! H11_HUMAN [Term] id: CCO:B0012000 name: H11_HUMAN-Phosphothreonine162 def: "Protein H11_HUMAN with the residue 162 substituted with Phosphothreonine" [UniProtKB:Q02539] xref: UniProtKB:Q02539 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005863 ! H11_HUMAN [Term] id: CCO:B0012001 name: H14_HUMAN-N-acetylserine2 def: "Protein H14_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P10412] xref: UniProtKB:P10412 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005838 ! H14_HUMAN [Term] id: CCO:B0012002 name: H14_HUMAN-Phosphothreonine4 def: "Protein H14_HUMAN with the residue 4 substituted with Phosphothreonine" [UniProtKB:P10412] comment: By similarity xref: UniProtKB:P10412 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005838 ! H14_HUMAN [Term] id: CCO:B0012003 name: H14_HUMAN-Phosphothreonine18 def: "Protein H14_HUMAN with the residue 18 substituted with Phosphothreonine" [UniProtKB:P10412] xref: UniProtKB:P10412 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005838 ! H14_HUMAN [Term] id: CCO:B0012004 name: H14_HUMAN-N6-methyllysine26 def: "Protein H14_HUMAN with the residue 26 substituted with N6-methyllysine" [UniProtKB:P10412] comment: partial; xref: UniProtKB:P10412 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005838 ! H14_HUMAN [Term] id: CCO:B0012005 name: H14_HUMAN-Phosphoserine27 def: "Protein H14_HUMAN with the residue 27 substituted with Phosphoserine" [UniProtKB:P10412] xref: UniProtKB:P10412 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005838 ! H14_HUMAN [Term] id: CCO:B0012006 name: H14_HUMAN-Phosphoserine36 def: "Protein H14_HUMAN with the residue 36 substituted with Phosphoserine" [UniProtKB:P10412] xref: UniProtKB:P10412 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005838 ! H14_HUMAN [Term] id: CCO:B0012007 name: H14_HUMAN-Phosphoserine187 def: "Protein H14_HUMAN with the residue 187 substituted with Phosphoserine" [UniProtKB:P10412] xref: UniProtKB:P10412 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005838 ! H14_HUMAN [Term] id: CCO:B0012008 name: H2AX_HUMAN-N-acetylserine2 def: "Protein H2AX_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P16104] comment: By similarity xref: UniProtKB:P16104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:B0012009 name: H2AX_HUMAN-Phosphoserine2 def: "Protein H2AX_HUMAN with the residue 2 substituted with Phosphoserine" [UniProtKB:P16104] comment: By similarity xref: UniProtKB:P16104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:B0012010 name: H2AX_HUMAN-Phosphoserine140 def: "Protein H2AX_HUMAN with the residue 140 substituted with Phosphoserine" [UniProtKB:P16104] comment: by ATM, ATR and PRKDC; xref: UniProtKB:P16104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000113 ! nucleosome relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000296 ! chromosome relationship: transformation_of CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:B0012011 name: H2B1C_HUMAN-N6-acetyllysine6 def: "Protein H2B1C_HUMAN with the residue 6 substituted with N6-acetyllysine" [UniProtKB:P62807] xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012012 name: H2B1C_HUMAN-N6-acetyllysine12 def: "Protein H2B1C_HUMAN with the residue 12 substituted with N6-acetyllysine" [UniProtKB:P62807] xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012013 name: H2B1C_HUMAN-N6-acetyllysine13 def: "Protein H2B1C_HUMAN with the residue 13 substituted with N6-acetyllysine" [UniProtKB:P62807] xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012014 name: H2B1C_HUMAN-Phosphoserine15 def: "Protein H2B1C_HUMAN with the residue 15 substituted with Phosphoserine" [UniProtKB:P62807] comment: by STK4; xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012015 name: H2B1C_HUMAN-N6-acetyllysine16 def: "Protein H2B1C_HUMAN with the residue 16 substituted with N6-acetyllysine" [UniProtKB:P62807] xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012016 name: H2B1C_HUMAN-N6-acetyllysine17 def: "Protein H2B1C_HUMAN with the residue 17 substituted with N6-acetyllysine" [UniProtKB:P62807] xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012017 name: H2B1C_HUMAN-N6-acetyllysine21 def: "Protein H2B1C_HUMAN with the residue 21 substituted with N6-acetyllysine" [UniProtKB:P62807] xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012018 name: H2B1C_HUMAN-N6-acetyllysine24 def: "Protein H2B1C_HUMAN with the residue 24 substituted with N6-acetyllysine" [UniProtKB:P62807] xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012019 name: H2B1C_HUMAN-N6-methyllysine47 def: "Protein H2B1C_HUMAN with the residue 47 substituted with N6-methyllysine" [UniProtKB:P62807] xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012020 name: H2B1C_HUMAN-N6,N6-dimethyllysine58 def: "Protein H2B1C_HUMAN with the residue 58 substituted with N6,N6-dimethyllysine" [UniProtKB:P62807] xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012021 name: H2B1C_HUMAN-N6-acetyllysine109 def: "Protein H2B1C_HUMAN with the residue 109 substituted with N6-acetyllysine" [UniProtKB:P62807] comment: alternate; xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012022 name: H2B1C_HUMAN-N6-methyllysine109 def: "Protein H2B1C_HUMAN with the residue 109 substituted with N6-methyllysine" [UniProtKB:P62807] comment: alternate; xref: UniProtKB:P62807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005771 ! H2B1C_HUMAN [Term] id: CCO:B0012023 name: H31_HUMAN-Phosphothreonine4 def: "Protein H31_HUMAN with the residue 4 substituted with Phosphothreonine" [UniProtKB:P68431] xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012024 name: H31_HUMAN-N6-acetyllysine5 def: "Protein H31_HUMAN with the residue 5 substituted with N6-acetyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012025 name: H31_HUMAN-N6-methyllysine5 def: "Protein H31_HUMAN with the residue 5 substituted with N6-methyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012026 name: H31_HUMAN-Citrulline9 def: "Protein H31_HUMAN with the residue 9 substituted with Citrulline" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012027 name: H31_HUMAN-dimethylarginine9 def: "Protein H31_HUMAN with the residue 9 substituted with dimethylarginine" [UniProtKB:P68431] comment: by PRMT5; alternate; By similarity xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012028 name: H31_HUMAN-N6,N6,N6-trimethyllysine10 def: "Protein H31_HUMAN with the residue 10 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012029 name: H31_HUMAN-N6,N6-dimethyllysine10 def: "Protein H31_HUMAN with the residue 10 substituted with N6,N6-dimethyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012030 name: H31_HUMAN-N6-acetyllysine10 def: "Protein H31_HUMAN with the residue 10 substituted with N6-acetyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012031 name: H31_HUMAN-N6-methyllysine10 def: "Protein H31_HUMAN with the residue 10 substituted with N6-methyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012032 name: H31_HUMAN-Phosphoserine11 def: "Protein H31_HUMAN with the residue 11 substituted with Phosphoserine" [UniProtKB:P68431] xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012033 name: H31_HUMAN-Phosphothreonine12 def: "Protein H31_HUMAN with the residue 12 substituted with Phosphothreonine" [UniProtKB:P68431] xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012034 name: H31_HUMAN-N6-acetyllysine15 def: "Protein H31_HUMAN with the residue 15 substituted with N6-acetyllysine" [UniProtKB:P68431] xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012035 name: H31_HUMAN-dimethylarginine18 def: "Protein H31_HUMAN with the residue 18 substituted with dimethylarginine" [UniProtKB:P68431] comment: by CARM1; alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012036 name: H31_HUMAN-Citrulline18 def: "Protein H31_HUMAN with the residue 18 substituted with Citrulline" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012037 name: H31_HUMAN-N6-acetyllysine19 def: "Protein H31_HUMAN with the residue 19 substituted with N6-acetyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012038 name: H31_HUMAN-N6-methyllysine19 def: "Protein H31_HUMAN with the residue 19 substituted with N6-methyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012039 name: H31_HUMAN-N6-acetyllysine24 def: "Protein H31_HUMAN with the residue 24 substituted with N6-acetyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012040 name: H31_HUMAN-N6-methyllysine24 def: "Protein H31_HUMAN with the residue 24 substituted with N6-methyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012041 name: H31_HUMAN-N6,N6,N6-trimethyllysine28 def: "Protein H31_HUMAN with the residue 28 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012042 name: H31_HUMAN-N6,N6-dimethyllysine28 def: "Protein H31_HUMAN with the residue 28 substituted with N6,N6-dimethyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012043 name: H31_HUMAN-N6-acetyllysine28 def: "Protein H31_HUMAN with the residue 28 substituted with N6-acetyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012044 name: H31_HUMAN-N6-methyllysine28 def: "Protein H31_HUMAN with the residue 28 substituted with N6-methyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012045 name: H31_HUMAN-Phosphoserine29 def: "Protein H31_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:P68431] xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012046 name: H31_HUMAN-N6,N6,N6-trimethyllysine37 def: "Protein H31_HUMAN with the residue 37 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012047 name: H31_HUMAN-N6,N6-dimethyllysine37 def: "Protein H31_HUMAN with the residue 37 substituted with N6,N6-dimethyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012048 name: H31_HUMAN-N6-acetyllysine37 def: "Protein H31_HUMAN with the residue 37 substituted with N6-acetyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012049 name: H31_HUMAN-N6-methyllysine37 def: "Protein H31_HUMAN with the residue 37 substituted with N6-methyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012050 name: H31_HUMAN-N6-methyllysine38 def: "Protein H31_HUMAN with the residue 38 substituted with N6-methyllysine" [UniProtKB:P68431] xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012051 name: H31_HUMAN-N6,N6,N6-trimethyllysine57 def: "Protein H31_HUMAN with the residue 57 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012052 name: H31_HUMAN-N6-acetyllysine57 def: "Protein H31_HUMAN with the residue 57 substituted with N6-acetyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012053 name: H31_HUMAN-N6-methyllysine57 def: "Protein H31_HUMAN with the residue 57 substituted with N6-methyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012054 name: H31_HUMAN-N6-methyllysine65 def: "Protein H31_HUMAN with the residue 65 substituted with N6-methyllysine" [UniProtKB:P68431] xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012055 name: H31_HUMAN-N6,N6,N6-trimethyllysine80 def: "Protein H31_HUMAN with the residue 80 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P68431] comment: alternate; By similarity xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012056 name: H31_HUMAN-N6,N6-dimethyllysine80 def: "Protein H31_HUMAN with the residue 80 substituted with N6,N6-dimethyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012057 name: H31_HUMAN-N6-acetyllysine80 def: "Protein H31_HUMAN with the residue 80 substituted with N6-acetyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012058 name: H31_HUMAN-N6-methyllysine80 def: "Protein H31_HUMAN with the residue 80 substituted with N6-methyllysine" [UniProtKB:P68431] comment: alternate; xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012059 name: H31_HUMAN-N6-methyllysine123 def: "Protein H31_HUMAN with the residue 123 substituted with N6-methyllysine" [UniProtKB:P68431] xref: UniProtKB:P68431 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005221 ! H31_HUMAN [Term] id: CCO:B0012060 name: H32_HUMAN-Phosphothreonine4 def: "Protein H32_HUMAN with the residue 4 substituted with Phosphothreonine" [UniProtKB:Q71DI3] xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012061 name: H32_HUMAN-N6-acetyllysine5 def: "Protein H32_HUMAN with the residue 5 substituted with N6-acetyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012062 name: H32_HUMAN-N6-methyllysine5 def: "Protein H32_HUMAN with the residue 5 substituted with N6-methyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012063 name: H32_HUMAN-Citrulline9 def: "Protein H32_HUMAN with the residue 9 substituted with Citrulline" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012064 name: H32_HUMAN-dimethylarginine9 def: "Protein H32_HUMAN with the residue 9 substituted with dimethylarginine" [UniProtKB:Q71DI3] comment: by PRMT5; alternate; By similarity xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012065 name: H32_HUMAN-N6,N6,N6-trimethyllysine10 def: "Protein H32_HUMAN with the residue 10 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012066 name: H32_HUMAN-N6,N6-dimethyllysine10 def: "Protein H32_HUMAN with the residue 10 substituted with N6,N6-dimethyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012067 name: H32_HUMAN-N6-acetyllysine10 def: "Protein H32_HUMAN with the residue 10 substituted with N6-acetyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012068 name: H32_HUMAN-N6-methyllysine10 def: "Protein H32_HUMAN with the residue 10 substituted with N6-methyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012069 name: H32_HUMAN-Phosphoserine11 def: "Protein H32_HUMAN with the residue 11 substituted with Phosphoserine" [UniProtKB:Q71DI3] xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012070 name: H32_HUMAN-Phosphothreonine12 def: "Protein H32_HUMAN with the residue 12 substituted with Phosphothreonine" [UniProtKB:Q71DI3] xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012071 name: H32_HUMAN-N6-acetyllysine15 def: "Protein H32_HUMAN with the residue 15 substituted with N6-acetyllysine" [UniProtKB:Q71DI3] xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012072 name: H32_HUMAN-dimethylarginine18 def: "Protein H32_HUMAN with the residue 18 substituted with dimethylarginine" [UniProtKB:Q71DI3] comment: by CARM1; alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012073 name: H32_HUMAN-Citrulline18 def: "Protein H32_HUMAN with the residue 18 substituted with Citrulline" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012074 name: H32_HUMAN-N6-acetyllysine19 def: "Protein H32_HUMAN with the residue 19 substituted with N6-acetyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012075 name: H32_HUMAN-N6-methyllysine19 def: "Protein H32_HUMAN with the residue 19 substituted with N6-methyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012076 name: H32_HUMAN-N6-acetyllysine24 def: "Protein H32_HUMAN with the residue 24 substituted with N6-acetyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012077 name: H32_HUMAN-N6-methyllysine24 def: "Protein H32_HUMAN with the residue 24 substituted with N6-methyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012078 name: H32_HUMAN-N6,N6,N6-trimethyllysine28 def: "Protein H32_HUMAN with the residue 28 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012079 name: H32_HUMAN-N6,N6-dimethyllysine28 def: "Protein H32_HUMAN with the residue 28 substituted with N6,N6-dimethyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012080 name: H32_HUMAN-N6-acetyllysine28 def: "Protein H32_HUMAN with the residue 28 substituted with N6-acetyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012081 name: H32_HUMAN-N6-methyllysine28 def: "Protein H32_HUMAN with the residue 28 substituted with N6-methyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012082 name: H32_HUMAN-Phosphoserine29 def: "Protein H32_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:Q71DI3] xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012083 name: H32_HUMAN-N6,N6,N6-trimethyllysine37 def: "Protein H32_HUMAN with the residue 37 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012084 name: H32_HUMAN-N6,N6-dimethyllysine37 def: "Protein H32_HUMAN with the residue 37 substituted with N6,N6-dimethyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012085 name: H32_HUMAN-N6-acetyllysine37 def: "Protein H32_HUMAN with the residue 37 substituted with N6-acetyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012086 name: H32_HUMAN-N6-methyllysine37 def: "Protein H32_HUMAN with the residue 37 substituted with N6-methyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012087 name: H32_HUMAN-N6,N6,N6-trimethyllysine57 def: "Protein H32_HUMAN with the residue 57 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012088 name: H32_HUMAN-N6-acetyllysine57 def: "Protein H32_HUMAN with the residue 57 substituted with N6-acetyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012089 name: H32_HUMAN-N6-methyllysine57 def: "Protein H32_HUMAN with the residue 57 substituted with N6-methyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012090 name: H32_HUMAN-N6-methyllysine65 def: "Protein H32_HUMAN with the residue 65 substituted with N6-methyllysine" [UniProtKB:Q71DI3] xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012091 name: H32_HUMAN-N6,N6,N6-trimethyllysine80 def: "Protein H32_HUMAN with the residue 80 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:Q71DI3] comment: alternate; By similarity xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012092 name: H32_HUMAN-N6,N6-dimethyllysine80 def: "Protein H32_HUMAN with the residue 80 substituted with N6,N6-dimethyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012093 name: H32_HUMAN-N6-acetyllysine80 def: "Protein H32_HUMAN with the residue 80 substituted with N6-acetyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012094 name: H32_HUMAN-N6-methyllysine80 def: "Protein H32_HUMAN with the residue 80 substituted with N6-methyllysine" [UniProtKB:Q71DI3] comment: alternate; xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012095 name: H32_HUMAN-N6-methyllysine123 def: "Protein H32_HUMAN with the residue 123 substituted with N6-methyllysine" [UniProtKB:Q71DI3] xref: UniProtKB:Q71DI3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005285 ! H32_HUMAN [Term] id: CCO:B0012096 name: H33_HUMAN-Phosphothreonine4 def: "Protein H33_HUMAN with the residue 4 substituted with Phosphothreonine" [UniProtKB:P84243] xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012097 name: H33_HUMAN-N6-acetyllysine5 def: "Protein H33_HUMAN with the residue 5 substituted with N6-acetyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012098 name: H33_HUMAN-N6-methyllysine5 def: "Protein H33_HUMAN with the residue 5 substituted with N6-methyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012099 name: H33_HUMAN-Citrulline9 def: "Protein H33_HUMAN with the residue 9 substituted with Citrulline" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012100 name: H33_HUMAN-dimethylarginine9 def: "Protein H33_HUMAN with the residue 9 substituted with dimethylarginine" [UniProtKB:P84243] comment: by PRMT5; alternate; By similarity xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012101 name: H33_HUMAN-N6,N6,N6-trimethyllysine10 def: "Protein H33_HUMAN with the residue 10 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012102 name: H33_HUMAN-N6,N6-dimethyllysine10 def: "Protein H33_HUMAN with the residue 10 substituted with N6,N6-dimethyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012103 name: H33_HUMAN-N6-acetyllysine10 def: "Protein H33_HUMAN with the residue 10 substituted with N6-acetyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012104 name: H33_HUMAN-N6-methyllysine10 def: "Protein H33_HUMAN with the residue 10 substituted with N6-methyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012105 name: H33_HUMAN-Phosphoserine11 def: "Protein H33_HUMAN with the residue 11 substituted with Phosphoserine" [UniProtKB:P84243] xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012106 name: H33_HUMAN-Phosphothreonine12 def: "Protein H33_HUMAN with the residue 12 substituted with Phosphothreonine" [UniProtKB:P84243] xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012107 name: H33_HUMAN-N6-acetyllysine15 def: "Protein H33_HUMAN with the residue 15 substituted with N6-acetyllysine" [UniProtKB:P84243] xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012108 name: H33_HUMAN-dimethylarginine18 def: "Protein H33_HUMAN with the residue 18 substituted with dimethylarginine" [UniProtKB:P84243] comment: by CARM1; alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012109 name: H33_HUMAN-Citrulline18 def: "Protein H33_HUMAN with the residue 18 substituted with Citrulline" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012110 name: H33_HUMAN-N6-acetyllysine19 def: "Protein H33_HUMAN with the residue 19 substituted with N6-acetyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012111 name: H33_HUMAN-N6-methyllysine19 def: "Protein H33_HUMAN with the residue 19 substituted with N6-methyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012112 name: H33_HUMAN-N6-acetyllysine24 def: "Protein H33_HUMAN with the residue 24 substituted with N6-acetyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012113 name: H33_HUMAN-N6-methyllysine24 def: "Protein H33_HUMAN with the residue 24 substituted with N6-methyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012114 name: H33_HUMAN-N6,N6,N6-trimethyllysine28 def: "Protein H33_HUMAN with the residue 28 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012115 name: H33_HUMAN-N6,N6-dimethyllysine28 def: "Protein H33_HUMAN with the residue 28 substituted with N6,N6-dimethyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012116 name: H33_HUMAN-N6-acetyllysine28 def: "Protein H33_HUMAN with the residue 28 substituted with N6-acetyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012117 name: H33_HUMAN-N6-methyllysine28 def: "Protein H33_HUMAN with the residue 28 substituted with N6-methyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012118 name: H33_HUMAN-Phosphoserine29 def: "Protein H33_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:P84243] xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012119 name: H33_HUMAN-Phosphoserine32 def: "Protein H33_HUMAN with the residue 32 substituted with Phosphoserine" [UniProtKB:P84243] xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012120 name: H33_HUMAN-N6,N6,N6-trimethyllysine37 def: "Protein H33_HUMAN with the residue 37 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012121 name: H33_HUMAN-N6,N6-dimethyllysine37 def: "Protein H33_HUMAN with the residue 37 substituted with N6,N6-dimethyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012122 name: H33_HUMAN-N6-acetyllysine37 def: "Protein H33_HUMAN with the residue 37 substituted with N6-acetyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012123 name: H33_HUMAN-N6-methyllysine37 def: "Protein H33_HUMAN with the residue 37 substituted with N6-methyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012124 name: H33_HUMAN-N6,N6,N6-trimethyllysine57 def: "Protein H33_HUMAN with the residue 57 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012125 name: H33_HUMAN-N6-acetyllysine57 def: "Protein H33_HUMAN with the residue 57 substituted with N6-acetyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012126 name: H33_HUMAN-N6-methyllysine57 def: "Protein H33_HUMAN with the residue 57 substituted with N6-methyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012127 name: H33_HUMAN-N6-methyllysine65 def: "Protein H33_HUMAN with the residue 65 substituted with N6-methyllysine" [UniProtKB:P84243] xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012128 name: H33_HUMAN-N6,N6,N6-trimethyllysine80 def: "Protein H33_HUMAN with the residue 80 substituted with N6,N6,N6-trimethyllysine" [UniProtKB:P84243] comment: alternate; Probable xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012129 name: H33_HUMAN-N6,N6-dimethyllysine80 def: "Protein H33_HUMAN with the residue 80 substituted with N6,N6-dimethyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012130 name: H33_HUMAN-N6-acetyllysine80 def: "Protein H33_HUMAN with the residue 80 substituted with N6-acetyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012131 name: H33_HUMAN-N6-methyllysine80 def: "Protein H33_HUMAN with the residue 80 substituted with N6-methyllysine" [UniProtKB:P84243] comment: alternate; xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012132 name: H33_HUMAN-N6-methyllysine123 def: "Protein H33_HUMAN with the residue 123 substituted with N6-methyllysine" [UniProtKB:P84243] xref: UniProtKB:P84243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005927 ! H33_HUMAN [Term] id: CCO:B0012142 name: HASP_HUMAN-Phosphoserine220 def: "Protein HASP_HUMAN with the residue 220 substituted with Phosphoserine" [UniProtKB:Q8TF76] xref: UniProtKB:Q8TF76 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001999 ! HASP_HUMAN [Term] id: CCO:B0012143 name: HASP_HUMAN-Phosphothreonine253 def: "Protein HASP_HUMAN with the residue 253 substituted with Phosphothreonine" [UniProtKB:Q8TF76] xref: UniProtKB:Q8TF76 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001999 ! HASP_HUMAN [Term] id: CCO:B0012144 name: HCFC1_HUMAN-Phosphoserine598 def: "Protein HCFC1_HUMAN with the residue 598 substituted with Phosphoserine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012145 name: HCFC1_HUMAN-Phosphoserine666 def: "Protein HCFC1_HUMAN with the residue 666 substituted with Phosphoserine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012146 name: HCFC1_HUMAN-Phosphothreonine733 def: "Protein HCFC1_HUMAN with the residue 733 substituted with Phosphothreonine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012147 name: HCFC1_HUMAN-Phosphothreonine737 def: "Protein HCFC1_HUMAN with the residue 737 substituted with Phosphothreonine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012148 name: HCFC1_HUMAN-Phosphothreonine738 def: "Protein HCFC1_HUMAN with the residue 738 substituted with Phosphothreonine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012149 name: HCFC1_HUMAN-Phosphothreonine1491 def: "Protein HCFC1_HUMAN with the residue 1491 substituted with Phosphothreonine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012150 name: HCFC1_HUMAN-Phosphoserine1507 def: "Protein HCFC1_HUMAN with the residue 1507 substituted with Phosphoserine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012151 name: HCFC1_HUMAN-Phosphoserine2007 def: "Protein HCFC1_HUMAN with the residue 2007 substituted with Phosphoserine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012152 name: HCFC1_HUMAN-Phosphoserine2008 def: "Protein HCFC1_HUMAN with the residue 2008 substituted with Phosphoserine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012153 name: HCFC1_HUMAN-Phosphoserine2020 def: "Protein HCFC1_HUMAN with the residue 2020 substituted with Phosphoserine" [UniProtKB:P51610] xref: UniProtKB:P51610 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:B0012154 name: HCK_HUMAN-Phosphotyrosine411 def: "Protein HCK_HUMAN with the residue 411 substituted with Phosphotyrosine" [UniProtKB:P08631] comment: by autocatalysis; By similarity xref: UniProtKB:P08631 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005894 ! HCK_HUMAN [Term] id: CCO:B0012155 name: HDAC1_HUMAN-Phosphotyrosine221 def: "Protein HDAC1_HUMAN with the residue 221 substituted with Phosphotyrosine" [UniProtKB:Q13547] xref: UniProtKB:Q13547 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:B0012156 name: HDAC1_HUMAN-Phosphoserine393 def: "Protein HDAC1_HUMAN with the residue 393 substituted with Phosphoserine" [UniProtKB:Q13547] xref: UniProtKB:Q13547 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:B0012157 name: HDAC1_HUMAN-Phosphoserine421 def: "Protein HDAC1_HUMAN with the residue 421 substituted with Phosphoserine" [UniProtKB:Q13547] comment: by CK2; xref: UniProtKB:Q13547 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:B0012158 name: HDAC1_HUMAN-Phosphoserine423 def: "Protein HDAC1_HUMAN with the residue 423 substituted with Phosphoserine" [UniProtKB:Q13547] comment: by CK2; xref: UniProtKB:Q13547 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:B0012159 name: HDAC2_HUMAN-Phosphoserine394 def: "Protein HDAC2_HUMAN with the residue 394 substituted with Phosphoserine" [UniProtKB:Q92769] xref: UniProtKB:Q92769 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:B0012160 name: HDAC2_HUMAN-Phosphoserine407 def: "Protein HDAC2_HUMAN with the residue 407 substituted with Phosphoserine" [UniProtKB:Q92769] xref: UniProtKB:Q92769 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:B0012161 name: HDAC2_HUMAN-Phosphoserine422 def: "Protein HDAC2_HUMAN with the residue 422 substituted with Phosphoserine" [UniProtKB:Q92769] xref: UniProtKB:Q92769 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:B0012162 name: HDAC2_HUMAN-Phosphoserine424 def: "Protein HDAC2_HUMAN with the residue 424 substituted with Phosphoserine" [UniProtKB:Q92769] xref: UniProtKB:Q92769 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:B0012163 name: HDAC4_HUMAN-Phosphoserine246 def: "Protein HDAC4_HUMAN with the residue 246 substituted with Phosphoserine" [UniProtKB:P56524] comment: by CaMK4; xref: UniProtKB:P56524 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001679 ! HDAC4_HUMAN [Term] id: CCO:B0012164 name: HDAC4_HUMAN-Phosphoserine467 def: "Protein HDAC4_HUMAN with the residue 467 substituted with Phosphoserine" [UniProtKB:P56524] comment: by CaMK4; xref: UniProtKB:P56524 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001679 ! HDAC4_HUMAN [Term] id: CCO:B0012165 name: HDAC4_HUMAN-Phosphoserine632 def: "Protein HDAC4_HUMAN with the residue 632 substituted with Phosphoserine" [UniProtKB:P56524] comment: by CaMK4; xref: UniProtKB:P56524 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001679 ! HDAC4_HUMAN [Term] id: CCO:B0012166 name: HDAC5_HUMAN-Phosphoserine259 def: "Protein HDAC5_HUMAN with the residue 259 substituted with Phosphoserine" [UniProtKB:Q9UQL6] comment: by CaMK; xref: UniProtKB:Q9UQL6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002244 ! HDAC5_HUMAN [Term] id: CCO:B0012167 name: HDAC5_HUMAN-Phosphoserine498 def: "Protein HDAC5_HUMAN with the residue 498 substituted with Phosphoserine" [UniProtKB:Q9UQL6] comment: by CaMK; xref: UniProtKB:Q9UQL6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002244 ! HDAC5_HUMAN [Term] id: CCO:B0012168 name: HDAC6_HUMAN-Phosphoserine22 def: "Protein HDAC6_HUMAN with the residue 22 substituted with Phosphoserine" [UniProtKB:Q9UBN7] xref: UniProtKB:Q9UBN7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002192 ! HDAC6_HUMAN [Term] id: CCO:B0012169 name: HDAC6_HUMAN-Phosphothreonine30 def: "Protein HDAC6_HUMAN with the residue 30 substituted with Phosphothreonine" [UniProtKB:Q9UBN7] xref: UniProtKB:Q9UBN7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000323 ! actin binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0003208 ! specific transcriptional repressor activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0004208 ! enzyme binding relationship: has_function CCO:F0005720 ! histone deacetylase binding relationship: has_function CCO:F0005738 ! tubulin deacetylase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000008 ! histone deacetylase complex relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000434 ! microtubule relationship: transformation_of CCO:B0002192 ! HDAC6_HUMAN [Term] id: CCO:B0012172 name: HDAC9_HUMAN-Phosphoserine220 def: "Protein HDAC9_HUMAN with the residue 220 substituted with Phosphoserine" [UniProtKB:Q9UKV0] comment: By similarity xref: UniProtKB:Q9UKV0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002222 ! HDAC9_HUMAN [Term] id: CCO:B0012173 name: HDAC9_HUMAN-Phosphoserine240 def: "Protein HDAC9_HUMAN with the residue 240 substituted with Phosphoserine" [UniProtKB:Q9UKV0] comment: By similarity xref: UniProtKB:Q9UKV0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002222 ! HDAC9_HUMAN [Term] id: CCO:B0012174 name: HDAC9_HUMAN-Phosphoserine451 def: "Protein HDAC9_HUMAN with the residue 451 substituted with Phosphoserine" [UniProtKB:Q9UKV0] comment: By similarity xref: UniProtKB:Q9UKV0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002222 ! HDAC9_HUMAN [Term] id: CCO:B0012175 name: HD_HUMAN-Phosphoserine421 def: "Protein HD_HUMAN with the residue 421 substituted with Phosphoserine" [UniProtKB:P42858] xref: UniProtKB:P42858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005407 ! HD_HUMAN [Term] id: CCO:B0012176 name: HD_HUMAN-Phosphoserine1876 def: "Protein HD_HUMAN with the residue 1876 substituted with Phosphoserine" [UniProtKB:P42858] comment: By similarity xref: UniProtKB:P42858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005407 ! HD_HUMAN [Term] id: CCO:B0012177 name: HECAM_HUMAN-Phosphoserine278 def: "Protein HECAM_HUMAN with the residue 278 substituted with Phosphoserine" [UniProtKB:Q14CZ8] comment: By similarity xref: UniProtKB:Q14CZ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001796 ! HECAM_HUMAN [Term] id: CCO:B0012178 name: HECAM_HUMAN-Phosphoserine318 def: "Protein HECAM_HUMAN with the residue 318 substituted with Phosphoserine" [UniProtKB:Q14CZ8] comment: By similarity xref: UniProtKB:Q14CZ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001796 ! HECAM_HUMAN [Term] id: CCO:B0012179 name: HECAM_HUMAN-Phosphoserine350 def: "Protein HECAM_HUMAN with the residue 350 substituted with Phosphoserine" [UniProtKB:Q14CZ8] comment: By similarity xref: UniProtKB:Q14CZ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001796 ! HECAM_HUMAN [Term] id: CCO:B0012180 name: HEXI1_HUMAN-Phosphoserine97 def: "Protein HEXI1_HUMAN with the residue 97 substituted with Phosphoserine" [UniProtKB:O94992] xref: UniProtKB:O94992 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001217 ! cyclin-dependent protein kinase inhibitor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003206 ! transcription repressor activity relationship: has_function CCO:F0003544 ! snRNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001445 ! HEXI1_HUMAN [Term] id: CCO:B0012181 name: HEXI1_HUMAN-Phosphoserine98 def: "Protein HEXI1_HUMAN with the residue 98 substituted with Phosphoserine" [UniProtKB:O94992] xref: UniProtKB:O94992 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001445 ! HEXI1_HUMAN [Term] id: CCO:B0012182 name: HEXI2_HUMAN-Phosphoserine51 def: "Protein HEXI2_HUMAN with the residue 51 substituted with Phosphoserine" [UniProtKB:Q96MH2] xref: UniProtKB:Q96MH2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002049 ! HEXI2_HUMAN [Term] id: CCO:B0012183 name: HEXI2_HUMAN-Phosphoserine53 def: "Protein HEXI2_HUMAN with the residue 53 substituted with Phosphoserine" [UniProtKB:Q96MH2] xref: UniProtKB:Q96MH2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002049 ! HEXI2_HUMAN [Term] id: CCO:B0012184 name: HGF_HUMAN-Pyrrolidone carboxylic acid32 def: "Protein HGF_HUMAN with the residue 32 substituted with Pyrrolidone carboxylic acid" [UniProtKB:P14210] xref: UniProtKB:P14210 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001518 ! HGF_HUMAN [Term] id: CCO:B0012185 name: HGS_HUMAN-Phosphotyrosine216 def: "Protein HGS_HUMAN with the residue 216 substituted with Phosphotyrosine" [UniProtKB:O14964] xref: UniProtKB:O14964 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005280 ! HGS_HUMAN [Term] id: CCO:B0012186 name: HGS_HUMAN-Phosphotyrosine308 def: "Protein HGS_HUMAN with the residue 308 substituted with Phosphotyrosine" [UniProtKB:O14964] xref: UniProtKB:O14964 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005280 ! HGS_HUMAN [Term] id: CCO:B0012187 name: HGS_HUMAN-Phosphotyrosine329 def: "Protein HGS_HUMAN with the residue 329 substituted with Phosphotyrosine" [UniProtKB:O14964] comment: By similarity xref: UniProtKB:O14964 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005280 ! HGS_HUMAN [Term] id: CCO:B0012188 name: HGS_HUMAN-Phosphotyrosine334 def: "Protein HGS_HUMAN with the residue 334 substituted with Phosphotyrosine" [UniProtKB:O14964] comment: By similarity xref: UniProtKB:O14964 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005280 ! HGS_HUMAN [Term] id: CCO:B0012189 name: HIC1_HUMAN-Phosphoserine313 def: "Protein HIC1_HUMAN with the residue 313 substituted with Phosphoserine" [UniProtKB:Q14526] comment: By similarity xref: UniProtKB:Q14526 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001783 ! HIC1_HUMAN [Term] id: CCO:B0012190 name: HIC1_HUMAN-N6-acetyllysine333 def: "Protein HIC1_HUMAN with the residue 333 substituted with N6-acetyllysine" [UniProtKB:Q14526] comment: alternate; xref: UniProtKB:Q14526 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001783 ! HIC1_HUMAN [Term] id: CCO:B0012191 name: HIF1A_HUMAN-4-hydroxyproline402 def: "Protein HIF1A_HUMAN with the residue 402 substituted with 4-hydroxyproline" [UniProtKB:Q16665] xref: UniProtKB:Q16665 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:B0012192 name: HIF1A_HUMAN-N6-acetyllysine532 def: "Protein HIF1A_HUMAN with the residue 532 substituted with N6-acetyllysine" [UniProtKB:Q16665] xref: UniProtKB:Q16665 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:B0012193 name: HIF1A_HUMAN-4-hydroxyproline564 def: "Protein HIF1A_HUMAN with the residue 564 substituted with 4-hydroxyproline" [UniProtKB:Q16665] xref: UniProtKB:Q16665 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:B0012194 name: HIF1A_HUMAN-S-nitrosocysteine800 def: "Protein HIF1A_HUMAN with the residue 800 substituted with S-nitrosocysteine" [UniProtKB:Q16665] comment: Probable xref: UniProtKB:Q16665 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:B0012195 name: HIF1A_HUMAN-3-hydroxyasparagine803 def: "Protein HIF1A_HUMAN with the residue 803 substituted with 3-hydroxyasparagine" [UniProtKB:Q16665] xref: UniProtKB:Q16665 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:B0012196 name: HIPK1_HUMAN-Phosphotyrosine352 def: "Protein HIPK1_HUMAN with the residue 352 substituted with Phosphotyrosine" [UniProtKB:Q86Z02] comment: By similarity xref: UniProtKB:Q86Z02 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005675 ! HIPK1_HUMAN [Term] id: CCO:B0012197 name: HMGB1_HUMAN-N6-acetyllysine30 def: "Protein HMGB1_HUMAN with the residue 30 substituted with N6-acetyllysine" [UniProtKB:P09429] xref: UniProtKB:P09429 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005929 ! HMGB1_HUMAN [Term] id: CCO:B0012198 name: HMGB1_HUMAN-Phosphoserine35 def: "Protein HMGB1_HUMAN with the residue 35 substituted with Phosphoserine" [UniProtKB:P09429] xref: UniProtKB:P09429 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005929 ! HMGB1_HUMAN [Term] id: CCO:B0012199 name: HNF1A_HUMAN-Phosphothreonine74 def: "Protein HNF1A_HUMAN with the residue 74 substituted with Phosphothreonine" [UniProtKB:P20823] comment: By similarity xref: UniProtKB:P20823 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006008 ! HNF1A_HUMAN [Term] id: CCO:B0012200 name: HNRH1_HUMAN-N-acetylmethionine2 def: "Protein HNRH1_HUMAN with the residue 2 substituted with N-acetylmethionine" [UniProtKB:P31943] xref: UniProtKB:P31943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005732 ! HNRH1_HUMAN [Term] id: CCO:B0012201 name: HNRH1_HUMAN-Phosphoserine23 def: "Protein HNRH1_HUMAN with the residue 23 substituted with Phosphoserine" [UniProtKB:P31943] xref: UniProtKB:P31943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005732 ! HNRH1_HUMAN [Term] id: CCO:B0012202 name: HNRH1_HUMAN-Phosphoserine63 def: "Protein HNRH1_HUMAN with the residue 63 substituted with Phosphoserine" [UniProtKB:P31943] xref: UniProtKB:P31943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005732 ! HNRH1_HUMAN [Term] id: CCO:B0012203 name: HNRH1_HUMAN-Phosphothreonine100 def: "Protein HNRH1_HUMAN with the residue 100 substituted with Phosphothreonine" [UniProtKB:P31943] xref: UniProtKB:P31943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005732 ! HNRH1_HUMAN [Term] id: CCO:B0012204 name: HNRH1_HUMAN-Phosphoserine104 def: "Protein HNRH1_HUMAN with the residue 104 substituted with Phosphoserine" [UniProtKB:P31943] xref: UniProtKB:P31943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005732 ! HNRH1_HUMAN [Term] id: CCO:B0012205 name: HNRH1_HUMAN-Asymmetric dimethylarginine217 def: "Protein HNRH1_HUMAN with the residue 217 substituted with Asymmetric dimethylarginine" [UniProtKB:P31943] comment: By similarity xref: UniProtKB:P31943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005732 ! HNRH1_HUMAN [Term] id: CCO:B0012206 name: HNRH1_HUMAN-Phosphotyrosine246 def: "Protein HNRH1_HUMAN with the residue 246 substituted with Phosphotyrosine" [UniProtKB:P31943] xref: UniProtKB:P31943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005732 ! HNRH1_HUMAN [Term] id: CCO:B0012207 name: HNRH1_HUMAN-Phosphotyrosine306 def: "Protein HNRH1_HUMAN with the residue 306 substituted with Phosphotyrosine" [UniProtKB:P31943] xref: UniProtKB:P31943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005732 ! HNRH1_HUMAN [Term] id: CCO:B0012208 name: HNRH1_HUMAN-Phosphoserine310 def: "Protein HNRH1_HUMAN with the residue 310 substituted with Phosphoserine" [UniProtKB:P31943] xref: UniProtKB:P31943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005732 ! HNRH1_HUMAN [Term] id: CCO:B0012209 name: HNRH3_HUMAN-Asymmetric dimethylarginine121 def: "Protein HNRH3_HUMAN with the residue 121 substituted with Asymmetric dimethylarginine" [UniProtKB:P31942] xref: UniProtKB:P31942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006277 ! HNRH3_HUMAN [Term] id: CCO:B0012210 name: HNRH3_HUMAN-Phosphoserine216 def: "Protein HNRH3_HUMAN with the residue 216 substituted with Phosphoserine" [UniProtKB:P31942] xref: UniProtKB:P31942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006277 ! HNRH3_HUMAN [Term] id: CCO:B0012211 name: HNRH3_HUMAN-Phosphotyrosine296 def: "Protein HNRH3_HUMAN with the residue 296 substituted with Phosphotyrosine" [UniProtKB:P31942] xref: UniProtKB:P31942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006277 ! HNRH3_HUMAN [Term] id: CCO:B0012212 name: HNRPC_HUMAN-Phosphoserine138 def: "Protein HNRPC_HUMAN with the residue 138 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012213 name: HNRPC_HUMAN-Phosphoserine162 def: "Protein HNRPC_HUMAN with the residue 162 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012214 name: HNRPC_HUMAN-Phosphoserine233 def: "Protein HNRPC_HUMAN with the residue 233 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012215 name: HNRPC_HUMAN-Phosphoserine238 def: "Protein HNRPC_HUMAN with the residue 238 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012216 name: HNRPC_HUMAN-Phosphoserine239 def: "Protein HNRPC_HUMAN with the residue 239 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012217 name: HNRPC_HUMAN-Phosphoserine240 def: "Protein HNRPC_HUMAN with the residue 240 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012218 name: HNRPC_HUMAN-Phosphoserine241 def: "Protein HNRPC_HUMAN with the residue 241 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012219 name: HNRPC_HUMAN-Phosphoserine253 def: "Protein HNRPC_HUMAN with the residue 253 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012220 name: HNRPC_HUMAN-Phosphoserine260 def: "Protein HNRPC_HUMAN with the residue 260 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012221 name: HNRPC_HUMAN-Phosphoserine299 def: "Protein HNRPC_HUMAN with the residue 299 substituted with Phosphoserine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0012222 name: HNRPD_HUMAN-Phosphoserine80 def: "Protein HNRPD_HUMAN with the residue 80 substituted with Phosphoserine" [UniProtKB:Q14103] xref: UniProtKB:Q14103 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:B0012223 name: HNRPD_HUMAN-Phosphoserine82 def: "Protein HNRPD_HUMAN with the residue 82 substituted with Phosphoserine" [UniProtKB:Q14103] xref: UniProtKB:Q14103 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:B0012224 name: HNRPD_HUMAN-Phosphoserine83 def: "Protein HNRPD_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:Q14103] xref: UniProtKB:Q14103 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:B0012225 name: HNRPD_HUMAN-Phosphoserine87 def: "Protein HNRPD_HUMAN with the residue 87 substituted with Phosphoserine" [UniProtKB:Q14103] xref: UniProtKB:Q14103 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:B0012226 name: HNRPD_HUMAN-Phosphothreonine91 def: "Protein HNRPD_HUMAN with the residue 91 substituted with Phosphothreonine" [UniProtKB:Q14103] xref: UniProtKB:Q14103 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:B0012227 name: HNRPD_HUMAN-Phosphoserine190 def: "Protein HNRPD_HUMAN with the residue 190 substituted with Phosphoserine" [UniProtKB:Q14103] xref: UniProtKB:Q14103 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:B0012228 name: HNRPD_HUMAN-Phosphothreonine193 def: "Protein HNRPD_HUMAN with the residue 193 substituted with Phosphothreonine" [UniProtKB:Q14103] xref: UniProtKB:Q14103 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:B0012229 name: HNRPD_HUMAN-Omega-N-methylated arginine345 def: "Protein HNRPD_HUMAN with the residue 345 substituted with Omega-N-methylated arginine" [UniProtKB:Q14103] xref: UniProtKB:Q14103 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:B0012230 name: HNRPF_HUMAN-N-acetylmethionine2 def: "Protein HNRPF_HUMAN with the residue 2 substituted with N-acetylmethionine" [UniProtKB:P52597] xref: UniProtKB:P52597 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005814 ! HNRPF_HUMAN [Term] id: CCO:B0012231 name: HNRPF_HUMAN-Phosphoserine161 def: "Protein HNRPF_HUMAN with the residue 161 substituted with Phosphoserine" [UniProtKB:P52597] xref: UniProtKB:P52597 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005814 ! HNRPF_HUMAN [Term] id: CCO:B0012232 name: HNRPF_HUMAN-Phosphotyrosine246 def: "Protein HNRPF_HUMAN with the residue 246 substituted with Phosphotyrosine" [UniProtKB:P52597] xref: UniProtKB:P52597 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005814 ! HNRPF_HUMAN [Term] id: CCO:B0012233 name: HNRPF_HUMAN-Phosphoserine310 def: "Protein HNRPF_HUMAN with the residue 310 substituted with Phosphoserine" [UniProtKB:P52597] xref: UniProtKB:P52597 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005814 ! HNRPF_HUMAN [Term] id: CCO:B0012234 name: HNRPG_HUMAN-N-acetylmethionine1 def: "Protein HNRPG_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P38159] comment: alternate; xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012235 name: HNRPG_HUMAN-N-acetylvaline2 def: "Protein HNRPG_HUMAN with the residue 2 substituted with N-acetylvaline" [UniProtKB:P38159] xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012236 name: HNRPG_HUMAN-Phosphoserine58 def: "Protein HNRPG_HUMAN with the residue 58 substituted with Phosphoserine" [UniProtKB:P38159] xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012237 name: HNRPG_HUMAN-Phosphoserine88 def: "Protein HNRPG_HUMAN with the residue 88 substituted with Phosphoserine" [UniProtKB:P38159] xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012238 name: HNRPG_HUMAN-Phosphoserine165 def: "Protein HNRPG_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:P38159] comment: By similarity xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012239 name: HNRPG_HUMAN-Omega-N-methylated arginine185 def: "Protein HNRPG_HUMAN with the residue 185 substituted with Omega-N-methylated arginine" [UniProtKB:P38159] xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012240 name: HNRPG_HUMAN-Phosphoserine208 def: "Protein HNRPG_HUMAN with the residue 208 substituted with Phosphoserine" [UniProtKB:P38159] xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012241 name: HNRPG_HUMAN-Phosphoserine330 def: "Protein HNRPG_HUMAN with the residue 330 substituted with Phosphoserine" [UniProtKB:P38159] xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012242 name: HNRPG_HUMAN-Phosphoserine332 def: "Protein HNRPG_HUMAN with the residue 332 substituted with Phosphoserine" [UniProtKB:P38159] xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012243 name: HNRPG_HUMAN-Phosphoserine352 def: "Protein HNRPG_HUMAN with the residue 352 substituted with Phosphoserine" [UniProtKB:P38159] xref: UniProtKB:P38159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:B0012244 name: HNRPK_HUMAN-Phosphothreonine3 def: "Protein HNRPK_HUMAN with the residue 3 substituted with Phosphothreonine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0012245 name: HNRPK_HUMAN-Phosphoserine36 def: "Protein HNRPK_HUMAN with the residue 36 substituted with Phosphoserine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0012246 name: HNRPK_HUMAN-Phosphoserine116 def: "Protein HNRPK_HUMAN with the residue 116 substituted with Phosphoserine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0012247 name: HNRPK_HUMAN-Phosphoserine214 def: "Protein HNRPK_HUMAN with the residue 214 substituted with Phosphoserine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0012248 name: HNRPK_HUMAN-Phosphoserine216 def: "Protein HNRPK_HUMAN with the residue 216 substituted with Phosphoserine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0012249 name: HNRPK_HUMAN-Phosphoserine284 def: "Protein HNRPK_HUMAN with the residue 284 substituted with Phosphoserine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0012250 name: HNRPK_HUMAN-Omega-N-methylated arginine296 def: "Protein HNRPK_HUMAN with the residue 296 substituted with Omega-N-methylated arginine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0012251 name: HNRPK_HUMAN-Omega-N-methylated arginine299 def: "Protein HNRPK_HUMAN with the residue 299 substituted with Omega-N-methylated arginine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0012252 name: HNRPK_HUMAN-Phosphoserine379 def: "Protein HNRPK_HUMAN with the residue 379 substituted with Phosphoserine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0012253 name: HOOK1_HUMAN-Phosphoserine235 def: "Protein HOOK1_HUMAN with the residue 235 substituted with Phosphoserine" [UniProtKB:Q9UJC3] xref: UniProtKB:Q9UJC3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005594 ! HOOK1_HUMAN [Term] id: CCO:B0012254 name: HOOK1_HUMAN-Phosphothreonine699 def: "Protein HOOK1_HUMAN with the residue 699 substituted with Phosphothreonine" [UniProtKB:Q9UJC3] xref: UniProtKB:Q9UJC3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005594 ! HOOK1_HUMAN [Term] id: CCO:B0012255 name: HRX_HUMAN-Phosphoserine279 def: "Protein HRX_HUMAN with the residue 279 substituted with Phosphoserine" [UniProtKB:Q03164] xref: UniProtKB:Q03164 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005486 ! HRX_HUMAN [Term] id: CCO:B0012256 name: HRX_HUMAN-Phosphothreonine337 def: "Protein HRX_HUMAN with the residue 337 substituted with Phosphothreonine" [UniProtKB:Q03164] xref: UniProtKB:Q03164 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005486 ! HRX_HUMAN [Term] id: CCO:B0012257 name: HRX_HUMAN-Phosphoserine1837 def: "Protein HRX_HUMAN with the residue 1837 substituted with Phosphoserine" [UniProtKB:Q03164] xref: UniProtKB:Q03164 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005486 ! HRX_HUMAN [Term] id: CCO:B0012258 name: HRX_HUMAN-Phosphoserine2151 def: "Protein HRX_HUMAN with the residue 2151 substituted with Phosphoserine" [UniProtKB:Q03164] xref: UniProtKB:Q03164 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005486 ! HRX_HUMAN [Term] id: CCO:B0012259 name: HRX_HUMAN-Phosphoserine2866 def: "Protein HRX_HUMAN with the residue 2866 substituted with Phosphoserine" [UniProtKB:Q03164] xref: UniProtKB:Q03164 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005486 ! HRX_HUMAN [Term] id: CCO:B0012260 name: HRX_HUMAN-Phosphothreonine2940 def: "Protein HRX_HUMAN with the residue 2940 substituted with Phosphothreonine" [UniProtKB:Q03164] xref: UniProtKB:Q03164 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005486 ! HRX_HUMAN [Term] id: CCO:B0012261 name: HRX_HUMAN-Phosphoserine3036 def: "Protein HRX_HUMAN with the residue 3036 substituted with Phosphoserine" [UniProtKB:Q03164] xref: UniProtKB:Q03164 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005486 ! HRX_HUMAN [Term] id: CCO:B0012262 name: HRX_HUMAN-Phosphoserine3511 def: "Protein HRX_HUMAN with the residue 3511 substituted with Phosphoserine" [UniProtKB:Q03164] xref: UniProtKB:Q03164 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005486 ! HRX_HUMAN [Term] id: CCO:B0012263 name: HS90A_HUMAN-Phosphothreonine5 def: "Protein HS90A_HUMAN with the residue 5 substituted with Phosphothreonine" [UniProtKB:P07900] comment: by PRKDC; xref: UniProtKB:P07900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005698 ! HS90A_HUMAN [Term] id: CCO:B0012264 name: HS90A_HUMAN-Phosphothreonine7 def: "Protein HS90A_HUMAN with the residue 7 substituted with Phosphothreonine" [UniProtKB:P07900] comment: by PRKDC; xref: UniProtKB:P07900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005698 ! HS90A_HUMAN [Term] id: CCO:B0012265 name: HS90A_HUMAN-Phosphoserine231 def: "Protein HS90A_HUMAN with the residue 231 substituted with Phosphoserine" [UniProtKB:P07900] xref: UniProtKB:P07900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005698 ! HS90A_HUMAN [Term] id: CCO:B0012266 name: HS90A_HUMAN-Phosphoserine252 def: "Protein HS90A_HUMAN with the residue 252 substituted with Phosphoserine" [UniProtKB:P07900] xref: UniProtKB:P07900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005698 ! HS90A_HUMAN [Term] id: CCO:B0012267 name: HS90A_HUMAN-Phosphoserine263 def: "Protein HS90A_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:P07900] xref: UniProtKB:P07900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005698 ! HS90A_HUMAN [Term] id: CCO:B0012268 name: HS90B_HUMAN-Phosphoserine226 def: "Protein HS90B_HUMAN with the residue 226 substituted with Phosphoserine" [UniProtKB:P08238] xref: UniProtKB:P08238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005580 ! HS90B_HUMAN [Term] id: CCO:B0012269 name: HS90B_HUMAN-Phosphoserine255 def: "Protein HS90B_HUMAN with the residue 255 substituted with Phosphoserine" [UniProtKB:P08238] xref: UniProtKB:P08238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005580 ! HS90B_HUMAN [Term] id: CCO:B0012270 name: HS90B_HUMAN-Phosphoserine261 def: "Protein HS90B_HUMAN with the residue 261 substituted with Phosphoserine" [UniProtKB:P08238] xref: UniProtKB:P08238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005580 ! HS90B_HUMAN [Term] id: CCO:B0012271 name: HS90B_HUMAN-Phosphothreonine297 def: "Protein HS90B_HUMAN with the residue 297 substituted with Phosphothreonine" [UniProtKB:P08238] xref: UniProtKB:P08238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005580 ! HS90B_HUMAN [Term] id: CCO:B0012272 name: HS90B_HUMAN-Phosphotyrosine484 def: "Protein HS90B_HUMAN with the residue 484 substituted with Phosphotyrosine" [UniProtKB:P08238] xref: UniProtKB:P08238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005580 ! HS90B_HUMAN [Term] id: CCO:B0012273 name: HS90B_HUMAN-N6-acetyllysine624 def: "Protein HS90B_HUMAN with the residue 624 substituted with N6-acetyllysine" [UniProtKB:P08238] xref: UniProtKB:P08238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005580 ! HS90B_HUMAN [Term] id: CCO:B0012274 name: HSP71_HUMAN-Phosphotyrosine611 def: "Protein HSP71_HUMAN with the residue 611 substituted with Phosphotyrosine" [UniProtKB:P08107] xref: UniProtKB:P08107 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005822 ! HSP71_HUMAN [Term] id: CCO:B0012275 name: HSP71_HUMAN-Phosphoserine631 def: "Protein HSP71_HUMAN with the residue 631 substituted with Phosphoserine" [UniProtKB:P08107] xref: UniProtKB:P08107 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005822 ! HSP71_HUMAN [Term] id: CCO:B0012276 name: HSP7C_HUMAN-Phosphotyrosine15 def: "Protein HSP7C_HUMAN with the residue 15 substituted with Phosphotyrosine" [UniProtKB:P11142] xref: UniProtKB:P11142 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005699 ! HSP7C_HUMAN [Term] id: CCO:B0012277 name: HSP7C_HUMAN-Phosphoserine153 def: "Protein HSP7C_HUMAN with the residue 153 substituted with Phosphoserine" [UniProtKB:P11142] xref: UniProtKB:P11142 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005699 ! HSP7C_HUMAN [Term] id: CCO:B0012278 name: HSP7C_HUMAN-Phosphothreonine477 def: "Protein HSP7C_HUMAN with the residue 477 substituted with Phosphothreonine" [UniProtKB:P11142] xref: UniProtKB:P11142 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005699 ! HSP7C_HUMAN [Term] id: CCO:B0012279 name: HSPB1_HUMAN-Phosphoserine15 def: "Protein HSPB1_HUMAN with the residue 15 substituted with Phosphoserine" [UniProtKB:P04792] xref: UniProtKB:P04792 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005842 ! HSPB1_HUMAN [Term] id: CCO:B0012280 name: HSPB1_HUMAN-Phosphoserine26 def: "Protein HSPB1_HUMAN with the residue 26 substituted with Phosphoserine" [UniProtKB:P04792] comment: By similarity xref: UniProtKB:P04792 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005842 ! HSPB1_HUMAN [Term] id: CCO:B0012281 name: HSPB1_HUMAN-Phosphoserine65 def: "Protein HSPB1_HUMAN with the residue 65 substituted with Phosphoserine" [UniProtKB:P04792] xref: UniProtKB:P04792 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005842 ! HSPB1_HUMAN [Term] id: CCO:B0012282 name: HSPB1_HUMAN-Phosphoserine78 def: "Protein HSPB1_HUMAN with the residue 78 substituted with Phosphoserine" [UniProtKB:P04792] xref: UniProtKB:P04792 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005842 ! HSPB1_HUMAN [Term] id: CCO:B0012283 name: HSPB1_HUMAN-Phosphoserine82 def: "Protein HSPB1_HUMAN with the residue 82 substituted with Phosphoserine" [UniProtKB:P04792] xref: UniProtKB:P04792 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005842 ! HSPB1_HUMAN [Term] id: CCO:B0012284 name: HSPB1_HUMAN-Phosphoserine83 def: "Protein HSPB1_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:P04792] xref: UniProtKB:P04792 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005842 ! HSPB1_HUMAN [Term] id: CCO:B0012285 name: HSPB1_HUMAN-N6-acetyllysine123 def: "Protein HSPB1_HUMAN with the residue 123 substituted with N6-acetyllysine" [UniProtKB:P04792] xref: UniProtKB:P04792 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005842 ! HSPB1_HUMAN [Term] id: CCO:B0012286 name: HTAI2_HUMAN-Phosphoserine45 def: "Protein HTAI2_HUMAN with the residue 45 substituted with Phosphoserine" [UniProtKB:Q9BUP3] comment: By similarity xref: UniProtKB:Q9BUP3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002098 ! HTAI2_HUMAN [Term] id: CCO:B0012287 name: HUWE1_HUMAN-Phosphoserine1395 def: "Protein HUWE1_HUMAN with the residue 1395 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012288 name: HUWE1_HUMAN-Phosphoserine1907 def: "Protein HUWE1_HUMAN with the residue 1907 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012289 name: HUWE1_HUMAN-Phosphoserine2362 def: "Protein HUWE1_HUMAN with the residue 2362 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012290 name: HUWE1_HUMAN-Phosphoserine2377 def: "Protein HUWE1_HUMAN with the residue 2377 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012291 name: HUWE1_HUMAN-Phosphoserine2887 def: "Protein HUWE1_HUMAN with the residue 2887 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012292 name: HUWE1_HUMAN-Phosphoserine2918 def: "Protein HUWE1_HUMAN with the residue 2918 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012293 name: HUWE1_HUMAN-Phosphoserine3757 def: "Protein HUWE1_HUMAN with the residue 3757 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] comment: By similarity xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012294 name: HUWE1_HUMAN-Phosphoserine3797 def: "Protein HUWE1_HUMAN with the residue 3797 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012295 name: HUWE1_HUMAN-Phosphoserine3808 def: "Protein HUWE1_HUMAN with the residue 3808 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012296 name: HUWE1_HUMAN-Phosphoserine3816 def: "Protein HUWE1_HUMAN with the residue 3816 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012297 name: HUWE1_HUMAN-Phosphothreonine3822 def: "Protein HUWE1_HUMAN with the residue 3822 substituted with Phosphothreonine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012298 name: HUWE1_HUMAN-Phosphoserine3919 def: "Protein HUWE1_HUMAN with the residue 3919 substituted with Phosphoserine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012299 name: HUWE1_HUMAN-Phosphothreonine3924 def: "Protein HUWE1_HUMAN with the residue 3924 substituted with Phosphothreonine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012300 name: HUWE1_HUMAN-Phosphothreonine3927 def: "Protein HUWE1_HUMAN with the residue 3927 substituted with Phosphothreonine" [UniProtKB:Q7Z6Z7] xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012301 name: HUWE1_HUMAN-Phosphotyrosine4271 def: "Protein HUWE1_HUMAN with the residue 4271 substituted with Phosphotyrosine" [UniProtKB:Q7Z6Z7] comment: By similarity xref: UniProtKB:Q7Z6Z7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:B0012302 name: IF2B_HUMAN-Phosphoserine2 def: "Protein IF2B_HUMAN with the residue 2 substituted with Phosphoserine" [UniProtKB:P20042] xref: UniProtKB:P20042 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006090 ! IF2B_HUMAN [Term] id: CCO:B0012303 name: IF2B_HUMAN-Phosphoserine67 def: "Protein IF2B_HUMAN with the residue 67 substituted with Phosphoserine" [UniProtKB:P20042] comment: By similarity xref: UniProtKB:P20042 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006090 ! IF2B_HUMAN [Term] id: CCO:B0012333 name: IF4G2_HUMAN-N-acetylmethionine1 def: "Protein IF4G2_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P78344] xref: UniProtKB:P78344 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001699 ! IF4G2_HUMAN [Term] id: CCO:B0012334 name: IF4G2_HUMAN-Phosphoserine395 def: "Protein IF4G2_HUMAN with the residue 395 substituted with Phosphoserine" [UniProtKB:P78344] xref: UniProtKB:P78344 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001699 ! IF4G2_HUMAN [Term] id: CCO:B0012335 name: IF4G2_HUMAN-Phosphothreonine508 def: "Protein IF4G2_HUMAN with the residue 508 substituted with Phosphothreonine" [UniProtKB:P78344] xref: UniProtKB:P78344 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001699 ! IF4G2_HUMAN [Term] id: CCO:B0012336 name: IGF1R_HUMAN-Phosphotyrosine980 def: "Protein IGF1R_HUMAN with the residue 980 substituted with Phosphotyrosine" [UniProtKB:P08069] comment: by autocatalysis; xref: UniProtKB:P08069 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001497 ! IGF1R_HUMAN [Term] id: CCO:B0012337 name: IGF1R_HUMAN-Phosphotyrosine1161 def: "Protein IGF1R_HUMAN with the residue 1161 substituted with Phosphotyrosine" [UniProtKB:P08069] comment: by autocatalysis; By similarity xref: UniProtKB:P08069 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001497 ! IGF1R_HUMAN [Term] id: CCO:B0012338 name: IGF1R_HUMAN-Phosphotyrosine1165 def: "Protein IGF1R_HUMAN with the residue 1165 substituted with Phosphotyrosine" [UniProtKB:P08069] comment: by autocatalysis; By similarity xref: UniProtKB:P08069 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001497 ! IGF1R_HUMAN [Term] id: CCO:B0012339 name: IGF1R_HUMAN-Phosphotyrosine1166 def: "Protein IGF1R_HUMAN with the residue 1166 substituted with Phosphotyrosine" [UniProtKB:P08069] comment: by autocatalysis; By similarity xref: UniProtKB:P08069 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001497 ! IGF1R_HUMAN [Term] id: CCO:B0012340 name: IKBA_HUMAN-Phosphoserine32 def: "Protein IKBA_HUMAN with the residue 32 substituted with Phosphoserine" [UniProtKB:P25963] comment: by IKKA and IKKE; xref: UniProtKB:P25963 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:B0012341 name: IKBA_HUMAN-Phosphoserine36 def: "Protein IKBA_HUMAN with the residue 36 substituted with Phosphoserine" [UniProtKB:P25963] comment: by IKKA, IKKB and IKKE; xref: UniProtKB:P25963 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:B0012342 name: IKBA_HUMAN-Phosphotyrosine42 def: "Protein IKBA_HUMAN with the residue 42 substituted with Phosphotyrosine" [UniProtKB:P25963] comment: by Tyr-kinases; xref: UniProtKB:P25963 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:B0012343 name: IKBB_HUMAN-Phosphoserine19 def: "Protein IKBB_HUMAN with the residue 19 substituted with Phosphoserine" [UniProtKB:Q15653] comment: By similarity xref: UniProtKB:Q15653 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005537 ! IKBB_HUMAN [Term] id: CCO:B0012344 name: IKBB_HUMAN-Phosphoserine23 def: "Protein IKBB_HUMAN with the residue 23 substituted with Phosphoserine" [UniProtKB:Q15653] comment: By similarity xref: UniProtKB:Q15653 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005537 ! IKBB_HUMAN [Term] id: CCO:B0012345 name: IKBE_HUMAN-Phosphoserine18 def: "Protein IKBE_HUMAN with the residue 18 substituted with Phosphoserine" [UniProtKB:O00221] comment: Probable xref: UniProtKB:O00221 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005538 ! IKBE_HUMAN [Term] id: CCO:B0012346 name: IKBE_HUMAN-Phosphoserine22 def: "Protein IKBE_HUMAN with the residue 22 substituted with Phosphoserine" [UniProtKB:O00221] comment: Probable xref: UniProtKB:O00221 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005538 ! IKBE_HUMAN [Term] id: CCO:B0012347 name: IKKA_HUMAN-Phosphothreonine23 def: "Protein IKKA_HUMAN with the residue 23 substituted with Phosphothreonine" [UniProtKB:O15111] comment: by PKB/AKT1; xref: UniProtKB:O15111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005539 ! IKKA_HUMAN [Term] id: CCO:B0012348 name: IKKA_HUMAN-Phosphoserine176 def: "Protein IKKA_HUMAN with the residue 176 substituted with Phosphoserine" [UniProtKB:O15111] comment: by MAP3K14; xref: UniProtKB:O15111 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005539 ! IKKA_HUMAN [Term] id: CCO:B0012349 name: IKKB_HUMAN-Phosphothreonine23 def: "Protein IKKB_HUMAN with the residue 23 substituted with Phosphothreonine" [UniProtKB:O14920] comment: By similarity xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012350 name: IKKB_HUMAN-Phosphoserine177 def: "Protein IKKB_HUMAN with the residue 177 substituted with Phosphoserine" [UniProtKB:O14920] xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012351 name: IKKB_HUMAN-Phosphoserine181 def: "Protein IKKB_HUMAN with the residue 181 substituted with Phosphoserine" [UniProtKB:O14920] xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012352 name: IKKB_HUMAN-Phosphoserine670 def: "Protein IKKB_HUMAN with the residue 670 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012353 name: IKKB_HUMAN-Phosphoserine672 def: "Protein IKKB_HUMAN with the residue 672 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012354 name: IKKB_HUMAN-Phosphoserine675 def: "Protein IKKB_HUMAN with the residue 675 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012355 name: IKKB_HUMAN-Phosphoserine682 def: "Protein IKKB_HUMAN with the residue 682 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012356 name: IKKB_HUMAN-Phosphoserine689 def: "Protein IKKB_HUMAN with the residue 689 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012357 name: IKKB_HUMAN-Phosphoserine692 def: "Protein IKKB_HUMAN with the residue 692 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012358 name: IKKB_HUMAN-Phosphoserine695 def: "Protein IKKB_HUMAN with the residue 695 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012359 name: IKKB_HUMAN-Phosphoserine697 def: "Protein IKKB_HUMAN with the residue 697 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012360 name: IKKB_HUMAN-Phosphoserine705 def: "Protein IKKB_HUMAN with the residue 705 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012361 name: IKKB_HUMAN-Phosphoserine733 def: "Protein IKKB_HUMAN with the residue 733 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012362 name: IKKB_HUMAN-Phosphoserine740 def: "Protein IKKB_HUMAN with the residue 740 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012363 name: IKKB_HUMAN-Phosphoserine750 def: "Protein IKKB_HUMAN with the residue 750 substituted with Phosphoserine" [UniProtKB:O14920] comment: by autocatalysis; Probable xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0012364 name: IKKE_HUMAN-Phosphoserine172 def: "Protein IKKE_HUMAN with the residue 172 substituted with Phosphoserine" [UniProtKB:Q14164] xref: UniProtKB:Q14164 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005523 ! IKKE_HUMAN [Term] id: CCO:B0012366 name: ILF3_HUMAN-Phosphoserine62 def: "Protein ILF3_HUMAN with the residue 62 substituted with Phosphoserine" [UniProtKB:Q12906] xref: UniProtKB:Q12906 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001734 ! ILF3_HUMAN [Term] id: CCO:B0012367 name: ILF3_HUMAN-Phosphoserine190 def: "Protein ILF3_HUMAN with the residue 190 substituted with Phosphoserine" [UniProtKB:Q12906] xref: UniProtKB:Q12906 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001734 ! ILF3_HUMAN [Term] id: CCO:B0012368 name: ILF3_HUMAN-Phosphoserine382 def: "Protein ILF3_HUMAN with the residue 382 substituted with Phosphoserine" [UniProtKB:Q12906] xref: UniProtKB:Q12906 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001734 ! ILF3_HUMAN [Term] id: CCO:B0012369 name: ILF3_HUMAN-Phosphoserine384 def: "Protein ILF3_HUMAN with the residue 384 substituted with Phosphoserine" [UniProtKB:Q12906] xref: UniProtKB:Q12906 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001734 ! ILF3_HUMAN [Term] id: CCO:B0012370 name: ILF3_HUMAN-Phosphoserine482 def: "Protein ILF3_HUMAN with the residue 482 substituted with Phosphoserine" [UniProtKB:Q12906] xref: UniProtKB:Q12906 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001734 ! ILF3_HUMAN [Term] id: CCO:B0012371 name: ILF3_HUMAN-Phosphothreonine592 def: "Protein ILF3_HUMAN with the residue 592 substituted with Phosphothreonine" [UniProtKB:Q12906] xref: UniProtKB:Q12906 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001734 ! ILF3_HUMAN [Term] id: CCO:B0012372 name: ILF3_HUMAN-Omega-N-methylated arginine609 def: "Protein ILF3_HUMAN with the residue 609 substituted with Omega-N-methylated arginine" [UniProtKB:Q12906] xref: UniProtKB:Q12906 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001734 ! ILF3_HUMAN [Term] id: CCO:B0012373 name: ILF3_HUMAN-Phosphoserine812 def: "Protein ILF3_HUMAN with the residue 812 substituted with Phosphoserine" [UniProtKB:Q12906] xref: UniProtKB:Q12906 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001734 ! ILF3_HUMAN [Term] id: CCO:B0012375 name: IMA2_HUMAN-Phosphoserine24 def: "Protein IMA2_HUMAN with the residue 24 substituted with Phosphoserine" [UniProtKB:P52292] xref: UniProtKB:P52292 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001657 ! IMA2_HUMAN [Term] id: CCO:B0012376 name: IMA2_HUMAN-Phosphoserine62 def: "Protein IMA2_HUMAN with the residue 62 substituted with Phosphoserine" [UniProtKB:P52292] xref: UniProtKB:P52292 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001657 ! IMA2_HUMAN [Term] id: CCO:B0012377 name: IMA2_HUMAN-Phosphoserine490 def: "Protein IMA2_HUMAN with the residue 490 substituted with Phosphoserine" [UniProtKB:P52292] xref: UniProtKB:P52292 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001633 ! binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001742 ! nuclear localization sequence binding relationship: has_function CCO:F0001997 ! protein transporter activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000260 ! nuclear pore relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001657 ! IMA2_HUMAN [Term] id: CCO:B0012378 name: IMA3_HUMAN-Phosphoserine60 def: "Protein IMA3_HUMAN with the residue 60 substituted with Phosphoserine" [UniProtKB:O00505] xref: UniProtKB:O00505 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005931 ! IMA3_HUMAN [Term] id: CCO:B0012379 name: IMB1_HUMAN-N-acetylmethionine1 def: "Protein IMB1_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:Q14974] xref: UniProtKB:Q14974 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005409 ! IMB1_HUMAN [Term] id: CCO:B0012380 name: IMMT_HUMAN-N6-acetyllysine506 def: "Protein IMMT_HUMAN with the residue 506 substituted with N6-acetyllysine" [UniProtKB:Q16891] comment: By similarity xref: UniProtKB:Q16891 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006201 ! IMMT_HUMAN [Term] id: CCO:B0012381 name: INCE_HUMAN-Phosphotyrosine73 def: "Protein INCE_HUMAN with the residue 73 substituted with Phosphotyrosine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012382 name: INCE_HUMAN-Phosphoserine119 def: "Protein INCE_HUMAN with the residue 119 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012383 name: INCE_HUMAN-Phosphoserine142 def: "Protein INCE_HUMAN with the residue 142 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012384 name: INCE_HUMAN-Phosphoserine143 def: "Protein INCE_HUMAN with the residue 143 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012385 name: INCE_HUMAN-Phosphoserine148 def: "Protein INCE_HUMAN with the residue 148 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012386 name: INCE_HUMAN-Phosphoserine197 def: "Protein INCE_HUMAN with the residue 197 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012387 name: INCE_HUMAN-Phosphothreonine199 def: "Protein INCE_HUMAN with the residue 199 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012388 name: INCE_HUMAN-Phosphothreonine213 def: "Protein INCE_HUMAN with the residue 213 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012389 name: INCE_HUMAN-Phosphoserine214 def: "Protein INCE_HUMAN with the residue 214 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012390 name: INCE_HUMAN-Phosphothreonine219 def: "Protein INCE_HUMAN with the residue 219 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012391 name: INCE_HUMAN-Phosphoserine230 def: "Protein INCE_HUMAN with the residue 230 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012392 name: INCE_HUMAN-Phosphothreonine239 def: "Protein INCE_HUMAN with the residue 239 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012393 name: INCE_HUMAN-Phosphoserine263 def: "Protein INCE_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012394 name: INCE_HUMAN-Phosphoserine269 def: "Protein INCE_HUMAN with the residue 269 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012395 name: INCE_HUMAN-Phosphoserine275 def: "Protein INCE_HUMAN with the residue 275 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012396 name: INCE_HUMAN-Phosphoserine291 def: "Protein INCE_HUMAN with the residue 291 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012397 name: INCE_HUMAN-Phosphothreonine292 def: "Protein INCE_HUMAN with the residue 292 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012398 name: INCE_HUMAN-Phosphothreonine294 def: "Protein INCE_HUMAN with the residue 294 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012399 name: INCE_HUMAN-Phosphoserine296 def: "Protein INCE_HUMAN with the residue 296 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012400 name: INCE_HUMAN-Phosphothreonine298 def: "Protein INCE_HUMAN with the residue 298 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012401 name: INCE_HUMAN-Phosphoserine306 def: "Protein INCE_HUMAN with the residue 306 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012402 name: INCE_HUMAN-Phosphoserine312 def: "Protein INCE_HUMAN with the residue 312 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012403 name: INCE_HUMAN-Phosphoserine314 def: "Protein INCE_HUMAN with the residue 314 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012404 name: INCE_HUMAN-Phosphoserine421 def: "Protein INCE_HUMAN with the residue 421 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012405 name: INCE_HUMAN-Phosphothreonine424 def: "Protein INCE_HUMAN with the residue 424 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012406 name: INCE_HUMAN-Phosphoserine481 def: "Protein INCE_HUMAN with the residue 481 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012407 name: INCE_HUMAN-Phosphoserine833 def: "Protein INCE_HUMAN with the residue 833 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012408 name: INCE_HUMAN-Phosphoserine836 def: "Protein INCE_HUMAN with the residue 836 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012409 name: INCE_HUMAN-Phosphothreonine837 def: "Protein INCE_HUMAN with the residue 837 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012410 name: INCE_HUMAN-Phosphothreonine897 def: "Protein INCE_HUMAN with the residue 897 substituted with Phosphothreonine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012411 name: INCE_HUMAN-Phosphoserine898 def: "Protein INCE_HUMAN with the residue 898 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012412 name: INCE_HUMAN-Phosphoserine899 def: "Protein INCE_HUMAN with the residue 899 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012413 name: INCE_HUMAN-Phosphoserine904 def: "Protein INCE_HUMAN with the residue 904 substituted with Phosphoserine" [UniProtKB:Q9NQS7] xref: UniProtKB:Q9NQS7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002154 ! INCE_HUMAN [Term] id: CCO:B0012414 name: ING4_HUMAN-N6-acetyllysine127 def: "Protein ING4_HUMAN with the residue 127 substituted with N6-acetyllysine" [UniProtKB:Q9UNL4] xref: UniProtKB:Q9UNL4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: transformation_of CCO:B0002234 ! ING4_HUMAN [Term] id: CCO:B0012415 name: ING4_HUMAN-N6-acetyllysine129 def: "Protein ING4_HUMAN with the residue 129 substituted with N6-acetyllysine" [UniProtKB:Q9UNL4] xref: UniProtKB:Q9UNL4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002234 ! ING4_HUMAN [Term] id: CCO:B0012416 name: ING4_HUMAN-N6-acetyllysine146 def: "Protein ING4_HUMAN with the residue 146 substituted with N6-acetyllysine" [UniProtKB:Q9UNL4] xref: UniProtKB:Q9UNL4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002234 ! ING4_HUMAN [Term] id: CCO:B0012417 name: ING4_HUMAN-N6-acetyllysine148 def: "Protein ING4_HUMAN with the residue 148 substituted with N6-acetyllysine" [UniProtKB:Q9UNL4] xref: UniProtKB:Q9UNL4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002234 ! ING4_HUMAN [Term] id: CCO:B0012418 name: ING5_HUMAN-Phosphoserine118 def: "Protein ING5_HUMAN with the residue 118 substituted with Phosphoserine" [UniProtKB:Q8WYH8] xref: UniProtKB:Q8WYH8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005284 ! ING5_HUMAN [Term] id: CCO:B0012419 name: INSR_HUMAN-Phosphotyrosine992 def: "Protein INSR_HUMAN with the residue 992 substituted with Phosphotyrosine" [UniProtKB:P06213] comment: by autocatalysis; Probable xref: UniProtKB:P06213 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005478 ! INSR_HUMAN [Term] id: CCO:B0012420 name: INSR_HUMAN-Phosphotyrosine999 def: "Protein INSR_HUMAN with the residue 999 substituted with Phosphotyrosine" [UniProtKB:P06213] comment: by autocatalysis; xref: UniProtKB:P06213 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005478 ! INSR_HUMAN [Term] id: CCO:B0012421 name: INSR_HUMAN-Phosphotyrosine1011 def: "Protein INSR_HUMAN with the residue 1011 substituted with Phosphotyrosine" [UniProtKB:P06213] comment: by autocatalysis; Probable xref: UniProtKB:P06213 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005478 ! INSR_HUMAN [Term] id: CCO:B0012422 name: INSR_HUMAN-Phosphotyrosine1185 def: "Protein INSR_HUMAN with the residue 1185 substituted with Phosphotyrosine" [UniProtKB:P06213] comment: by autocatalysis; xref: UniProtKB:P06213 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005478 ! INSR_HUMAN [Term] id: CCO:B0012423 name: INSR_HUMAN-Phosphotyrosine1189 def: "Protein INSR_HUMAN with the residue 1189 substituted with Phosphotyrosine" [UniProtKB:P06213] comment: by autocatalysis; xref: UniProtKB:P06213 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005478 ! INSR_HUMAN [Term] id: CCO:B0012424 name: INSR_HUMAN-Phosphotyrosine1190 def: "Protein INSR_HUMAN with the residue 1190 substituted with Phosphotyrosine" [UniProtKB:P06213] comment: by autocatalysis; xref: UniProtKB:P06213 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005478 ! INSR_HUMAN [Term] id: CCO:B0012425 name: INSR_HUMAN-Phosphotyrosine1355 def: "Protein INSR_HUMAN with the residue 1355 substituted with Phosphotyrosine" [UniProtKB:P06213] comment: by autocatalysis; xref: UniProtKB:P06213 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005478 ! INSR_HUMAN [Term] id: CCO:B0012426 name: INSR_HUMAN-Phosphotyrosine1361 def: "Protein INSR_HUMAN with the residue 1361 substituted with Phosphotyrosine" [UniProtKB:P06213] comment: by autocatalysis; xref: UniProtKB:P06213 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005478 ! INSR_HUMAN [Term] id: CCO:B0012427 name: IPO7_HUMAN-N-acetylmethionine1 def: "Protein IPO7_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:O95373] xref: UniProtKB:O95373 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005661 ! IPO7_HUMAN [Term] id: CCO:B0012428 name: IPO7_HUMAN-Phosphotyrosine311 def: "Protein IPO7_HUMAN with the residue 311 substituted with Phosphotyrosine" [UniProtKB:O95373] xref: UniProtKB:O95373 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005661 ! IPO7_HUMAN [Term] id: CCO:B0012434 name: JAK3_HUMAN-Phosphothreonine8 def: "Protein JAK3_HUMAN with the residue 8 substituted with Phosphothreonine" [UniProtKB:P52333] comment: By similarity xref: UniProtKB:P52333 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005612 ! JAK3_HUMAN [Term] id: CCO:B0012435 name: JAK3_HUMAN-Phosphotyrosine785 def: "Protein JAK3_HUMAN with the residue 785 substituted with Phosphotyrosine" [UniProtKB:P52333] xref: UniProtKB:P52333 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005612 ! JAK3_HUMAN [Term] id: CCO:B0012436 name: JAK3_HUMAN-Phosphotyrosine980 def: "Protein JAK3_HUMAN with the residue 980 substituted with Phosphotyrosine" [UniProtKB:P52333] comment: by autocatalysis; By similarity xref: UniProtKB:P52333 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005612 ! JAK3_HUMAN [Term] id: CCO:B0012437 name: JHD1A_HUMAN-Phosphoserine28 def: "Protein JHD1A_HUMAN with the residue 28 substituted with Phosphoserine" [UniProtKB:Q9Y2K7] xref: UniProtKB:Q9Y2K7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006051 ! JHD1A_HUMAN [Term] id: CCO:B0012438 name: JHD1A_HUMAN-Phosphothreonine534 def: "Protein JHD1A_HUMAN with the residue 534 substituted with Phosphothreonine" [UniProtKB:Q9Y2K7] xref: UniProtKB:Q9Y2K7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006051 ! JHD1A_HUMAN [Term] id: CCO:B0012439 name: JHD1A_HUMAN-Phosphothreonine632 def: "Protein JHD1A_HUMAN with the residue 632 substituted with Phosphothreonine" [UniProtKB:Q9Y2K7] xref: UniProtKB:Q9Y2K7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006051 ! JHD1A_HUMAN [Term] id: CCO:B0012440 name: JIP3_HUMAN-Phosphothreonine265 def: "Protein JIP3_HUMAN with the residue 265 substituted with Phosphothreonine" [UniProtKB:Q9UPT6] comment: by MAPK; By similarity xref: UniProtKB:Q9UPT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006034 ! JIP3_HUMAN [Term] id: CCO:B0012441 name: JIP3_HUMAN-Phosphoserine267 def: "Protein JIP3_HUMAN with the residue 267 substituted with Phosphoserine" [UniProtKB:Q9UPT6] comment: By similarity xref: UniProtKB:Q9UPT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006034 ! JIP3_HUMAN [Term] id: CCO:B0012442 name: JIP3_HUMAN-Phosphothreonine275 def: "Protein JIP3_HUMAN with the residue 275 substituted with Phosphothreonine" [UniProtKB:Q9UPT6] comment: by MAPK; By similarity xref: UniProtKB:Q9UPT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006034 ! JIP3_HUMAN [Term] id: CCO:B0012443 name: JIP3_HUMAN-Phosphothreonine286 def: "Protein JIP3_HUMAN with the residue 286 substituted with Phosphothreonine" [UniProtKB:Q9UPT6] comment: by MAPK; By similarity xref: UniProtKB:Q9UPT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006034 ! JIP3_HUMAN [Term] id: CCO:B0012444 name: JIP3_HUMAN-Phosphoserine365 def: "Protein JIP3_HUMAN with the residue 365 substituted with Phosphoserine" [UniProtKB:Q9UPT6] comment: By similarity xref: UniProtKB:Q9UPT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006034 ! JIP3_HUMAN [Term] id: CCO:B0012445 name: JIP3_HUMAN-Phosphoserine585 def: "Protein JIP3_HUMAN with the residue 585 substituted with Phosphoserine" [UniProtKB:Q9UPT6] xref: UniProtKB:Q9UPT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006034 ! JIP3_HUMAN [Term] id: CCO:B0012446 name: JIP3_HUMAN-Phosphoserine676 def: "Protein JIP3_HUMAN with the residue 676 substituted with Phosphoserine" [UniProtKB:Q9UPT6] comment: By similarity xref: UniProtKB:Q9UPT6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006034 ! JIP3_HUMAN [Term] id: CCO:B0012451 name: K0087_HUMAN-Phosphoserine6 def: "Protein K0087_HUMAN with the residue 6 substituted with Phosphoserine" [UniProtKB:Q14695] xref: UniProtKB:Q14695 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006280 ! K0087_HUMAN [Term] id: CCO:B0012452 name: K0087_HUMAN-Phosphoserine7 def: "Protein K0087_HUMAN with the residue 7 substituted with Phosphoserine" [UniProtKB:Q14695] xref: UniProtKB:Q14695 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006280 ! K0087_HUMAN [Term] id: CCO:B0012453 name: K1267_HUMAN-Phosphoserine1082 def: "Protein K1267_HUMAN with the residue 1082 substituted with Phosphoserine" [UniProtKB:Q7Z3B3] xref: UniProtKB:Q7Z3B3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005600 ! K1267_HUMAN [Term] id: CCO:B0012458 name: K1C17_HUMAN-Phosphoserine32 def: "Protein K1C17_HUMAN with the residue 32 substituted with Phosphoserine" [UniProtKB:Q04695] xref: UniProtKB:Q04695 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005844 ! K1C17_HUMAN [Term] id: CCO:B0012459 name: K1C17_HUMAN-Phosphoserine319 def: "Protein K1C17_HUMAN with the residue 319 substituted with Phosphoserine" [UniProtKB:Q04695] comment: By similarity xref: UniProtKB:Q04695 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005844 ! K1C17_HUMAN [Term] id: CCO:B0012460 name: K1C18_HUMAN-N-acetylserine2 def: "Protein K1C18_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P05783] xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012461 name: K1C18_HUMAN-Phosphoserine7 def: "Protein K1C18_HUMAN with the residue 7 substituted with Phosphoserine" [UniProtKB:P05783] xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012462 name: K1C18_HUMAN-Phosphothreonine8 def: "Protein K1C18_HUMAN with the residue 8 substituted with Phosphothreonine" [UniProtKB:P05783] comment: By similarity xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012463 name: K1C18_HUMAN-Phosphothreonine11 def: "Protein K1C18_HUMAN with the residue 11 substituted with Phosphothreonine" [UniProtKB:P05783] comment: By similarity xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012464 name: K1C18_HUMAN-Phosphoserine15 def: "Protein K1C18_HUMAN with the residue 15 substituted with Phosphoserine" [UniProtKB:P05783] xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012465 name: K1C18_HUMAN-Phosphoserine18 def: "Protein K1C18_HUMAN with the residue 18 substituted with Phosphoserine" [UniProtKB:P05783] xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012466 name: K1C18_HUMAN-Phosphoserine30 def: "Protein K1C18_HUMAN with the residue 30 substituted with Phosphoserine" [UniProtKB:P05783] comment: By similarity xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012467 name: K1C18_HUMAN-Phosphoserine31 def: "Protein K1C18_HUMAN with the residue 31 substituted with Phosphoserine" [UniProtKB:P05783] comment: By similarity xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012468 name: K1C18_HUMAN-Phosphoserine34 def: "Protein K1C18_HUMAN with the residue 34 substituted with Phosphoserine" [UniProtKB:P05783] comment: by CDC2; xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012469 name: K1C18_HUMAN-Phosphotyrosine36 def: "Protein K1C18_HUMAN with the residue 36 substituted with Phosphotyrosine" [UniProtKB:P05783] comment: By similarity xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012470 name: K1C18_HUMAN-Phosphoserine42 def: "Protein K1C18_HUMAN with the residue 42 substituted with Phosphoserine" [UniProtKB:P05783] comment: By similarity xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012471 name: K1C18_HUMAN-Phosphoserine53 def: "Protein K1C18_HUMAN with the residue 53 substituted with Phosphoserine" [UniProtKB:P05783] comment: by CAMK, PKC/PRKCE and STK6; xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012472 name: K1C18_HUMAN-Phosphoserine60 def: "Protein K1C18_HUMAN with the residue 60 substituted with Phosphoserine" [UniProtKB:P05783] xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012473 name: K1C18_HUMAN-Phosphoserine401 def: "Protein K1C18_HUMAN with the residue 401 substituted with Phosphoserine" [UniProtKB:P05783] comment: By similarity xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012474 name: K1C18_HUMAN-Phosphothreonine404 def: "Protein K1C18_HUMAN with the residue 404 substituted with Phosphothreonine" [UniProtKB:P05783] comment: By similarity xref: UniProtKB:P05783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001489 ! K1C18_HUMAN [Term] id: CCO:B0012475 name: K2C1_HUMAN-Phosphoserine21 def: "Protein K2C1_HUMAN with the residue 21 substituted with Phosphoserine" [UniProtKB:P04264] xref: UniProtKB:P04264 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005823 ! K2C1_HUMAN [Term] id: CCO:B0012476 name: K2C1_HUMAN-Phosphoserine66 def: "Protein K2C1_HUMAN with the residue 66 substituted with Phosphoserine" [UniProtKB:P04264] comment: By similarity xref: UniProtKB:P04264 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005823 ! K2C1_HUMAN [Term] id: CCO:B0012477 name: K2C1_HUMAN-Phosphotyrosine295 def: "Protein K2C1_HUMAN with the residue 295 substituted with Phosphotyrosine" [UniProtKB:P04264] xref: UniProtKB:P04264 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005823 ! K2C1_HUMAN [Term] id: CCO:B0012478 name: K2C1_HUMAN-Phosphothreonine297 def: "Protein K2C1_HUMAN with the residue 297 substituted with Phosphothreonine" [UniProtKB:P04264] xref: UniProtKB:P04264 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005823 ! K2C1_HUMAN [Term] id: CCO:B0012479 name: K2C5_HUMAN-Phosphoserine64 def: "Protein K2C5_HUMAN with the residue 64 substituted with Phosphoserine" [UniProtKB:P13647] comment: By similarity xref: UniProtKB:P13647 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005811 ! K2C5_HUMAN [Term] id: CCO:B0012480 name: K2C6A_HUMAN-Phosphoserine60 def: "Protein K2C6A_HUMAN with the residue 60 substituted with Phosphoserine" [UniProtKB:P02538] comment: By similarity xref: UniProtKB:P02538 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005821 ! K2C6A_HUMAN [Term] id: CCO:B0012481 name: K2C7_HUMAN-Phosphoserine14 def: "Protein K2C7_HUMAN with the residue 14 substituted with Phosphoserine" [UniProtKB:P08729] comment: By similarity xref: UniProtKB:P08729 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001501 ! K2C7_HUMAN [Term] id: CCO:B0012482 name: K2C7_HUMAN-Omega-N-methylated arginine20 def: "Protein K2C7_HUMAN with the residue 20 substituted with Omega-N-methylated arginine" [UniProtKB:P08729] xref: UniProtKB:P08729 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001501 ! K2C7_HUMAN [Term] id: CCO:B0012483 name: K2C7_HUMAN-Phosphoserine45 def: "Protein K2C7_HUMAN with the residue 45 substituted with Phosphoserine" [UniProtKB:P08729] xref: UniProtKB:P08729 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001501 ! K2C7_HUMAN [Term] id: CCO:B0012484 name: K2C7_HUMAN-Phosphoserine254 def: "Protein K2C7_HUMAN with the residue 254 substituted with Phosphoserine" [UniProtKB:P08729] xref: UniProtKB:P08729 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001501 ! K2C7_HUMAN [Term] id: CCO:B0012485 name: K2C7_HUMAN-Phosphotyrosine375 def: "Protein K2C7_HUMAN with the residue 375 substituted with Phosphotyrosine" [UniProtKB:P08729] xref: UniProtKB:P08729 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001501 ! K2C7_HUMAN [Term] id: CCO:B0012486 name: K2C7_HUMAN-Phosphoserine380 def: "Protein K2C7_HUMAN with the residue 380 substituted with Phosphoserine" [UniProtKB:P08729] xref: UniProtKB:P08729 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001501 ! K2C7_HUMAN [Term] id: CCO:B0012487 name: K2C8_HUMAN-Phosphoserine9 def: "Protein K2C8_HUMAN with the residue 9 substituted with Phosphoserine" [UniProtKB:P05787] comment: By similarity xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012488 name: K2C8_HUMAN-Phosphoserine13 def: "Protein K2C8_HUMAN with the residue 13 substituted with Phosphoserine" [UniProtKB:P05787] comment: By similarity xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012489 name: K2C8_HUMAN-Phosphoserine21 def: "Protein K2C8_HUMAN with the residue 21 substituted with Phosphoserine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012490 name: K2C8_HUMAN-Phosphoserine22 def: "Protein K2C8_HUMAN with the residue 22 substituted with Phosphoserine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012491 name: K2C8_HUMAN-Phosphoserine24 def: "Protein K2C8_HUMAN with the residue 24 substituted with Phosphoserine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012492 name: K2C8_HUMAN-Phosphothreonine26 def: "Protein K2C8_HUMAN with the residue 26 substituted with Phosphothreonine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012493 name: K2C8_HUMAN-Phosphoserine27 def: "Protein K2C8_HUMAN with the residue 27 substituted with Phosphoserine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012494 name: K2C8_HUMAN-Phosphoserine34 def: "Protein K2C8_HUMAN with the residue 34 substituted with Phosphoserine" [UniProtKB:P05787] comment: By similarity xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012495 name: K2C8_HUMAN-Phosphoserine37 def: "Protein K2C8_HUMAN with the residue 37 substituted with Phosphoserine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012496 name: K2C8_HUMAN-Phosphoserine43 def: "Protein K2C8_HUMAN with the residue 43 substituted with Phosphoserine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012497 name: K2C8_HUMAN-Phosphoserine44 def: "Protein K2C8_HUMAN with the residue 44 substituted with Phosphoserine" [UniProtKB:P05787] comment: By similarity xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012498 name: K2C8_HUMAN-Phosphoserine74 def: "Protein K2C8_HUMAN with the residue 74 substituted with Phosphoserine" [UniProtKB:P05787] comment: by MAPK; xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012499 name: K2C8_HUMAN-Phosphoserine253 def: "Protein K2C8_HUMAN with the residue 253 substituted with Phosphoserine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012500 name: K2C8_HUMAN-Phosphoserine330 def: "Protein K2C8_HUMAN with the residue 330 substituted with Phosphoserine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012501 name: K2C8_HUMAN-Phosphoserine417 def: "Protein K2C8_HUMAN with the residue 417 substituted with Phosphoserine" [UniProtKB:P05787] comment: By similarity xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012502 name: K2C8_HUMAN-Phosphoserine424 def: "Protein K2C8_HUMAN with the residue 424 substituted with Phosphoserine" [UniProtKB:P05787] comment: By similarity xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012503 name: K2C8_HUMAN-Phosphoserine432 def: "Protein K2C8_HUMAN with the residue 432 substituted with Phosphoserine" [UniProtKB:P05787] comment: by CaMK2 and MAPK; xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012504 name: K2C8_HUMAN-Phosphoserine451 def: "Protein K2C8_HUMAN with the residue 451 substituted with Phosphoserine" [UniProtKB:P05787] xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012505 name: K2C8_HUMAN-Phosphoserine475 def: "Protein K2C8_HUMAN with the residue 475 substituted with Phosphoserine" [UniProtKB:P05787] comment: By similarity xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012506 name: K2C8_HUMAN-Phosphoserine478 def: "Protein K2C8_HUMAN with the residue 478 substituted with Phosphoserine" [UniProtKB:P05787] comment: By similarity xref: UniProtKB:P05787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:B0012507 name: KAP0_HUMAN-N-acetylmethionine1 def: "Protein KAP0_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P10644] xref: UniProtKB:P10644 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005298 ! KAP0_HUMAN [Term] id: CCO:B0012508 name: KAP0_HUMAN-Phosphoserine77 def: "Protein KAP0_HUMAN with the residue 77 substituted with Phosphoserine" [UniProtKB:P10644] comment: By similarity xref: UniProtKB:P10644 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005298 ! KAP0_HUMAN [Term] id: CCO:B0012509 name: KAP0_HUMAN-Phosphoserine83 def: "Protein KAP0_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:P10644] xref: UniProtKB:P10644 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005298 ! KAP0_HUMAN [Term] id: CCO:B0012510 name: KAP0_HUMAN-Phosphoserine101 def: "Protein KAP0_HUMAN with the residue 101 substituted with Phosphoserine" [UniProtKB:P10644] comment: By similarity xref: UniProtKB:P10644 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005298 ! KAP0_HUMAN [Term] id: CCO:B0012511 name: KC1E_HUMAN-Phosphothreonine362 def: "Protein KC1E_HUMAN with the residue 362 substituted with Phosphothreonine" [UniProtKB:P49674] xref: UniProtKB:P49674 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005272 ! KC1E_HUMAN [Term] id: CCO:B0012512 name: KC1E_HUMAN-Phosphoserine363 def: "Protein KC1E_HUMAN with the residue 363 substituted with Phosphoserine" [UniProtKB:P49674] xref: UniProtKB:P49674 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005272 ! KC1E_HUMAN [Term] id: CCO:B0012514 name: KHDR1_HUMAN-Phosphoserine18 def: "Protein KHDR1_HUMAN with the residue 18 substituted with Phosphoserine" [UniProtKB:Q07666] xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012515 name: KHDR1_HUMAN-Phosphoserine20 def: "Protein KHDR1_HUMAN with the residue 20 substituted with Phosphoserine" [UniProtKB:Q07666] xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012516 name: KHDR1_HUMAN-Phosphothreonine33 def: "Protein KHDR1_HUMAN with the residue 33 substituted with Phosphothreonine" [UniProtKB:Q07666] xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012517 name: KHDR1_HUMAN-dimethylarginine45 def: "Protein KHDR1_HUMAN with the residue 45 substituted with dimethylarginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012518 name: KHDR1_HUMAN-dimethylarginine52 def: "Protein KHDR1_HUMAN with the residue 52 substituted with dimethylarginine" [UniProtKB:Q07666] comment: partial; by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012519 name: KHDR1_HUMAN-arginine291 def: "Protein KHDR1_HUMAN with the residue 291 substituted with arginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012520 name: KHDR1_HUMAN-dimethylarginine304 def: "Protein KHDR1_HUMAN with the residue 304 substituted with dimethylarginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012521 name: KHDR1_HUMAN-Omega-N-methylarginine310 def: "Protein KHDR1_HUMAN with the residue 310 substituted with Omega-N-methylarginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012522 name: KHDR1_HUMAN-Omega-N-methylarginine315 def: "Protein KHDR1_HUMAN with the residue 315 substituted with Omega-N-methylarginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012523 name: KHDR1_HUMAN-Omega-N-methylarginine320 def: "Protein KHDR1_HUMAN with the residue 320 substituted with Omega-N-methylarginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012524 name: KHDR1_HUMAN-Omega-N-methylarginine325 def: "Protein KHDR1_HUMAN with the residue 325 substituted with Omega-N-methylarginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012525 name: KHDR1_HUMAN-arginine331 def: "Protein KHDR1_HUMAN with the residue 331 substituted with arginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012526 name: KHDR1_HUMAN-Omega-N-methylarginine340 def: "Protein KHDR1_HUMAN with the residue 340 substituted with Omega-N-methylarginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012527 name: KHDR1_HUMAN-arginine346 def: "Protein KHDR1_HUMAN with the residue 346 substituted with arginine" [UniProtKB:Q07666] comment: by PRMT1; xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0012528 name: KHDR3_HUMAN-Phosphotyrosine5 def: "Protein KHDR3_HUMAN with the residue 5 substituted with Phosphotyrosine" [UniProtKB:O75525] xref: UniProtKB:O75525 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005275 ! KHDR3_HUMAN [Term] id: CCO:B0012529 name: KI13B_HUMAN-Phosphoserine1410 def: "Protein KI13B_HUMAN with the residue 1410 substituted with Phosphoserine" [UniProtKB:Q9NQT8] xref: UniProtKB:Q9NQT8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005849 ! KI13B_HUMAN [Term] id: CCO:B0012530 name: KI67_HUMAN-Phosphoserine108 def: "Protein KI67_HUMAN with the residue 108 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012531 name: KI67_HUMAN-Phosphoserine125 def: "Protein KI67_HUMAN with the residue 125 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012532 name: KI67_HUMAN-Phosphoserine128 def: "Protein KI67_HUMAN with the residue 128 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012533 name: KI67_HUMAN-Phosphoserine308 def: "Protein KI67_HUMAN with the residue 308 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012534 name: KI67_HUMAN-Phosphothreonine328 def: "Protein KI67_HUMAN with the residue 328 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012535 name: KI67_HUMAN-Phosphoserine357 def: "Protein KI67_HUMAN with the residue 357 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012536 name: KI67_HUMAN-Phosphoserine374 def: "Protein KI67_HUMAN with the residue 374 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012537 name: KI67_HUMAN-Phosphothreonine543 def: "Protein KI67_HUMAN with the residue 543 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012538 name: KI67_HUMAN-Phosphoserine579 def: "Protein KI67_HUMAN with the residue 579 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012539 name: KI67_HUMAN-Phosphoserine584 def: "Protein KI67_HUMAN with the residue 584 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012540 name: KI67_HUMAN-Phosphoserine648 def: "Protein KI67_HUMAN with the residue 648 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012541 name: KI67_HUMAN-Phosphoserine1098 def: "Protein KI67_HUMAN with the residue 1098 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012542 name: KI67_HUMAN-Phosphoserine1131 def: "Protein KI67_HUMAN with the residue 1131 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012543 name: KI67_HUMAN-Phosphothreonine1139 def: "Protein KI67_HUMAN with the residue 1139 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012544 name: KI67_HUMAN-Phosphothreonine1193 def: "Protein KI67_HUMAN with the residue 1193 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012545 name: KI67_HUMAN-Phosphoserine1207 def: "Protein KI67_HUMAN with the residue 1207 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012546 name: KI67_HUMAN-Phosphothreonine1233 def: "Protein KI67_HUMAN with the residue 1233 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012547 name: KI67_HUMAN-Phosphoserine1253 def: "Protein KI67_HUMAN with the residue 1253 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012548 name: KI67_HUMAN-Phosphothreonine1298 def: "Protein KI67_HUMAN with the residue 1298 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012549 name: KI67_HUMAN-Phosphoserine1302 def: "Protein KI67_HUMAN with the residue 1302 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012550 name: KI67_HUMAN-Phosphothreonine1327 def: "Protein KI67_HUMAN with the residue 1327 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012551 name: KI67_HUMAN-Phosphothreonine1335 def: "Protein KI67_HUMAN with the residue 1335 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012552 name: KI67_HUMAN-Phosphothreonine1355 def: "Protein KI67_HUMAN with the residue 1355 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012553 name: KI67_HUMAN-Phosphoserine1375 def: "Protein KI67_HUMAN with the residue 1375 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012554 name: KI67_HUMAN-Phosphoserine1376 def: "Protein KI67_HUMAN with the residue 1376 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012555 name: KI67_HUMAN-Phosphothreonine1557 def: "Protein KI67_HUMAN with the residue 1557 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012556 name: KI67_HUMAN-Phosphothreonine1569 def: "Protein KI67_HUMAN with the residue 1569 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012557 name: KI67_HUMAN-Phosphoserine1618 def: "Protein KI67_HUMAN with the residue 1618 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012558 name: KI67_HUMAN-Phosphoserine1629 def: "Protein KI67_HUMAN with the residue 1629 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012559 name: KI67_HUMAN-Phosphoserine1636 def: "Protein KI67_HUMAN with the residue 1636 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012560 name: KI67_HUMAN-Phosphoserine1679 def: "Protein KI67_HUMAN with the residue 1679 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012561 name: KI67_HUMAN-Phosphoserine1740 def: "Protein KI67_HUMAN with the residue 1740 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012562 name: KI67_HUMAN-Phosphothreonine1764 def: "Protein KI67_HUMAN with the residue 1764 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012563 name: KI67_HUMAN-Phosphothreonine1801 def: "Protein KI67_HUMAN with the residue 1801 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012564 name: KI67_HUMAN-Phosphoserine1815 def: "Protein KI67_HUMAN with the residue 1815 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012565 name: KI67_HUMAN-Phosphoserine1861 def: "Protein KI67_HUMAN with the residue 1861 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012566 name: KI67_HUMAN-Phosphothreonine1897 def: "Protein KI67_HUMAN with the residue 1897 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012567 name: KI67_HUMAN-Phosphothreonine1923 def: "Protein KI67_HUMAN with the residue 1923 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012568 name: KI67_HUMAN-Phosphoserine1937 def: "Protein KI67_HUMAN with the residue 1937 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012569 name: KI67_HUMAN-Phosphoserine2002 def: "Protein KI67_HUMAN with the residue 2002 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012570 name: KI67_HUMAN-Phosphothreonine2085 def: "Protein KI67_HUMAN with the residue 2085 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012571 name: KI67_HUMAN-Phosphoserine2105 def: "Protein KI67_HUMAN with the residue 2105 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012572 name: KI67_HUMAN-Phosphoserine2223 def: "Protein KI67_HUMAN with the residue 2223 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012573 name: KI67_HUMAN-Phosphothreonine2231 def: "Protein KI67_HUMAN with the residue 2231 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012574 name: KI67_HUMAN-Phosphothreonine2285 def: "Protein KI67_HUMAN with the residue 2285 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012575 name: KI67_HUMAN-Phosphothreonine2305 def: "Protein KI67_HUMAN with the residue 2305 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012576 name: KI67_HUMAN-Phosphothreonine2406 def: "Protein KI67_HUMAN with the residue 2406 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012577 name: KI67_HUMAN-Phosphoserine2505 def: "Protein KI67_HUMAN with the residue 2505 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012578 name: KI67_HUMAN-Phosphothreonine2508 def: "Protein KI67_HUMAN with the residue 2508 substituted with Phosphothreonine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012579 name: KI67_HUMAN-Phosphoserine2528 def: "Protein KI67_HUMAN with the residue 2528 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012580 name: KI67_HUMAN-Phosphoserine2708 def: "Protein KI67_HUMAN with the residue 2708 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012581 name: KI67_HUMAN-Phosphoserine2827 def: "Protein KI67_HUMAN with the residue 2827 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012582 name: KI67_HUMAN-Phosphoserine2828 def: "Protein KI67_HUMAN with the residue 2828 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0012583 name: KIF11_HUMAN-Phosphothreonine458 def: "Protein KIF11_HUMAN with the residue 458 substituted with Phosphothreonine" [UniProtKB:P52732] xref: UniProtKB:P52732 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001659 ! KIF11_HUMAN [Term] id: CCO:B0012584 name: KIF11_HUMAN-Phosphothreonine926 def: "Protein KIF11_HUMAN with the residue 926 substituted with Phosphothreonine" [UniProtKB:P52732] comment: by CDC2; xref: UniProtKB:P52732 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001659 ! KIF11_HUMAN [Term] id: CCO:B0012585 name: KIF11_HUMAN-Phosphoserine931 def: "Protein KIF11_HUMAN with the residue 931 substituted with Phosphoserine" [UniProtKB:P52732] xref: UniProtKB:P52732 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001659 ! KIF11_HUMAN [Term] id: CCO:B0012586 name: KIF22_HUMAN-Phosphoserine452 def: "Protein KIF22_HUMAN with the residue 452 substituted with Phosphoserine" [UniProtKB:Q14807] xref: UniProtKB:Q14807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001792 ! KIF22_HUMAN [Term] id: CCO:B0012587 name: KIF22_HUMAN-Phosphoserine543 def: "Protein KIF22_HUMAN with the residue 543 substituted with Phosphoserine" [UniProtKB:Q14807] xref: UniProtKB:Q14807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001792 ! KIF22_HUMAN [Term] id: CCO:B0012588 name: KIF22_HUMAN-Phosphoserine562 def: "Protein KIF22_HUMAN with the residue 562 substituted with Phosphoserine" [UniProtKB:Q14807] xref: UniProtKB:Q14807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001792 ! KIF22_HUMAN [Term] id: CCO:B0012589 name: KIF22_HUMAN-Phosphoserine581 def: "Protein KIF22_HUMAN with the residue 581 substituted with Phosphoserine" [UniProtKB:Q14807] xref: UniProtKB:Q14807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001792 ! KIF22_HUMAN [Term] id: CCO:B0012590 name: KIF23_HUMAN-Phosphotyrosine29 def: "Protein KIF23_HUMAN with the residue 29 substituted with Phosphotyrosine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012591 name: KIF23_HUMAN-Phosphoserine155 def: "Protein KIF23_HUMAN with the residue 155 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012592 name: KIF23_HUMAN-Phosphoserine160 def: "Protein KIF23_HUMAN with the residue 160 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012593 name: KIF23_HUMAN-Phosphothreonine450 def: "Protein KIF23_HUMAN with the residue 450 substituted with Phosphothreonine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012594 name: KIF23_HUMAN-Phosphoserine682 def: "Protein KIF23_HUMAN with the residue 682 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000321 ! motor activity relationship: has_function CCO:F0000322 ! microtubule motor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000431 ! kinesin complex relationship: located_in CCO:C0000434 ! microtubule relationship: located_in CCO:C0000435 ! microtubule associated complex relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012595 name: KIF23_HUMAN-Phosphoserine684 def: "Protein KIF23_HUMAN with the residue 684 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012596 name: KIF23_HUMAN-Phosphoserine686 def: "Protein KIF23_HUMAN with the residue 686 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012597 name: KIF23_HUMAN-Phosphothreonine738 def: "Protein KIF23_HUMAN with the residue 738 substituted with Phosphothreonine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012598 name: KIF23_HUMAN-Phosphoserine814 def: "Protein KIF23_HUMAN with the residue 814 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012599 name: KIF23_HUMAN-Phosphoserine867 def: "Protein KIF23_HUMAN with the residue 867 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012600 name: KIF23_HUMAN-Phosphoserine902 def: "Protein KIF23_HUMAN with the residue 902 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012601 name: KIF23_HUMAN-Phosphoserine911 def: "Protein KIF23_HUMAN with the residue 911 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012602 name: KIF23_HUMAN-Phosphoserine912 def: "Protein KIF23_HUMAN with the residue 912 substituted with Phosphoserine" [UniProtKB:Q02241] xref: UniProtKB:Q02241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001716 ! KIF23_HUMAN [Term] id: CCO:B0012603 name: KIF2C_HUMAN-Phosphoserine628 def: "Protein KIF2C_HUMAN with the residue 628 substituted with Phosphoserine" [UniProtKB:Q99661] xref: UniProtKB:Q99661 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002080 ! KIF2C_HUMAN [Term] id: CCO:B0012604 name: KIF2C_HUMAN-Phosphoserine629 def: "Protein KIF2C_HUMAN with the residue 629 substituted with Phosphoserine" [UniProtKB:Q99661] xref: UniProtKB:Q99661 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002080 ! KIF2C_HUMAN [Term] id: CCO:B0012605 name: KIF2C_HUMAN-Phosphoserine632 def: "Protein KIF2C_HUMAN with the residue 632 substituted with Phosphoserine" [UniProtKB:Q99661] xref: UniProtKB:Q99661 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002080 ! KIF2C_HUMAN [Term] id: CCO:B0012606 name: KIF2C_HUMAN-Phosphoserine633 def: "Protein KIF2C_HUMAN with the residue 633 substituted with Phosphoserine" [UniProtKB:Q99661] xref: UniProtKB:Q99661 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002080 ! KIF2C_HUMAN [Term] id: CCO:B0012607 name: KIF3A_HUMAN-Phosphoserine690 def: "Protein KIF3A_HUMAN with the residue 690 substituted with Phosphoserine" [UniProtKB:Q9Y496] comment: By similarity xref: UniProtKB:Q9Y496 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005880 ! KIF3A_HUMAN [Term] id: CCO:B0012608 name: KIF3C_HUMAN-Phosphothreonine585 def: "Protein KIF3C_HUMAN with the residue 585 substituted with Phosphothreonine" [UniProtKB:O14782] xref: UniProtKB:O14782 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005598 ! KIF3C_HUMAN [Term] id: CCO:B0012609 name: KIFC1_HUMAN-Phosphoserine33 def: "Protein KIFC1_HUMAN with the residue 33 substituted with Phosphoserine" [UniProtKB:Q9BW19] xref: UniProtKB:Q9BW19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000321 ! motor activity relationship: has_function CCO:F0000322 ! microtubule motor activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000351 ! endosome relationship: located_in CCO:C0000352 ! early endosome relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000434 ! microtubule relationship: located_in CCO:C0000435 ! microtubule associated complex relationship: transformation_of CCO:B0002105 ! KIFC1_HUMAN [Term] id: CCO:B0012610 name: KIFC1_HUMAN-Phosphoserine351 def: "Protein KIFC1_HUMAN with the residue 351 substituted with Phosphoserine" [UniProtKB:Q9BW19] xref: UniProtKB:Q9BW19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002105 ! KIFC1_HUMAN [Term] id: CCO:B0012611 name: KITH_HUMAN-Phosphoserine13 def: "Protein KITH_HUMAN with the residue 13 substituted with Phosphoserine" [UniProtKB:P04183] xref: UniProtKB:P04183 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006114 ! KITH_HUMAN [Term] id: CCO:B0012612 name: KITH_HUMAN-Phosphoserine231 def: "Protein KITH_HUMAN with the residue 231 substituted with Phosphoserine" [UniProtKB:P04183] xref: UniProtKB:P04183 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006114 ! KITH_HUMAN [Term] id: CCO:B0012613 name: KNTC1_HUMAN-Phosphoserine2098 def: "Protein KNTC1_HUMAN with the residue 2098 substituted with Phosphoserine" [UniProtKB:P50748] xref: UniProtKB:P50748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000144 ! spindle pole relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000396 ! kinetochore microtubule relationship: transformation_of CCO:B0001645 ! KNTC1_HUMAN [Term] id: CCO:B0012629 name: KPCI_HUMAN-Phosphotyrosine256 def: "Protein KPCI_HUMAN with the residue 256 substituted with Phosphotyrosine" [UniProtKB:P41743] comment: by Src; xref: UniProtKB:P41743 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:B0012630 name: KPCI_HUMAN-Phosphotyrosine271 def: "Protein KPCI_HUMAN with the residue 271 substituted with Phosphotyrosine" [UniProtKB:P41743] comment: by Src; xref: UniProtKB:P41743 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:B0012631 name: KPCI_HUMAN-Phosphotyrosine325 def: "Protein KPCI_HUMAN with the residue 325 substituted with Phosphotyrosine" [UniProtKB:P41743] comment: by Src; xref: UniProtKB:P41743 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:B0012632 name: KPCI_HUMAN-Phosphothreonine403 def: "Protein KPCI_HUMAN with the residue 403 substituted with Phosphothreonine" [UniProtKB:P41743] xref: UniProtKB:P41743 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:B0012633 name: KPCI_HUMAN-Phosphothreonine555 def: "Protein KPCI_HUMAN with the residue 555 substituted with Phosphothreonine" [UniProtKB:P41743] xref: UniProtKB:P41743 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:B0012634 name: KPCZ_HUMAN-Phosphoserine223 def: "Protein KPCZ_HUMAN with the residue 223 substituted with Phosphoserine" [UniProtKB:Q05513] xref: UniProtKB:Q05513 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005315 ! KPCZ_HUMAN [Term] id: CCO:B0012635 name: KPCZ_HUMAN-Phosphothreonine410 def: "Protein KPCZ_HUMAN with the residue 410 substituted with Phosphothreonine" [UniProtKB:Q05513] comment: by PDPK1; xref: UniProtKB:Q05513 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005315 ! KPCZ_HUMAN [Term] id: CCO:B0012636 name: KPCZ_HUMAN-Phosphothreonine560 def: "Protein KPCZ_HUMAN with the residue 560 substituted with Phosphothreonine" [UniProtKB:Q05513] comment: By similarity xref: UniProtKB:Q05513 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005315 ! KPCZ_HUMAN [Term] id: CCO:B0012637 name: KS6A4_HUMAN-Phosphoserine196 def: "Protein KS6A4_HUMAN with the residue 196 substituted with Phosphoserine" [UniProtKB:O75676] comment: By similarity xref: UniProtKB:O75676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005629 ! KS6A4_HUMAN [Term] id: CCO:B0012638 name: KS6A4_HUMAN-Phosphoserine343 def: "Protein KS6A4_HUMAN with the residue 343 substituted with Phosphoserine" [UniProtKB:O75676] comment: By similarity xref: UniProtKB:O75676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005629 ! KS6A4_HUMAN [Term] id: CCO:B0012639 name: KS6A4_HUMAN-Phosphoserine347 def: "Protein KS6A4_HUMAN with the residue 347 substituted with Phosphoserine" [UniProtKB:O75676] comment: By similarity xref: UniProtKB:O75676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005629 ! KS6A4_HUMAN [Term] id: CCO:B0012640 name: KS6A4_HUMAN-Phosphoserine360 def: "Protein KS6A4_HUMAN with the residue 360 substituted with Phosphoserine" [UniProtKB:O75676] comment: By similarity xref: UniProtKB:O75676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005629 ! KS6A4_HUMAN [Term] id: CCO:B0012641 name: KS6A4_HUMAN-Phosphothreonine568 def: "Protein KS6A4_HUMAN with the residue 568 substituted with Phosphothreonine" [UniProtKB:O75676] comment: By similarity xref: UniProtKB:O75676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005629 ! KS6A4_HUMAN [Term] id: CCO:B0012642 name: KS6A4_HUMAN-Phosphoserine681 def: "Protein KS6A4_HUMAN with the residue 681 substituted with Phosphoserine" [UniProtKB:O75676] xref: UniProtKB:O75676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005629 ! KS6A4_HUMAN [Term] id: CCO:B0012643 name: KS6A4_HUMAN-Phosphoserine682 def: "Protein KS6A4_HUMAN with the residue 682 substituted with Phosphoserine" [UniProtKB:O75676] xref: UniProtKB:O75676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005629 ! KS6A4_HUMAN [Term] id: CCO:B0012644 name: KS6A4_HUMAN-Phosphoserine737 def: "Protein KS6A4_HUMAN with the residue 737 substituted with Phosphoserine" [UniProtKB:O75676] comment: By similarity xref: UniProtKB:O75676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005629 ! KS6A4_HUMAN [Term] id: CCO:B0012647 name: KTNB1_HUMAN-Phosphothreonine395 def: "Protein KTNB1_HUMAN with the residue 395 substituted with Phosphothreonine" [UniProtKB:Q9BVA0] xref: UniProtKB:Q9BVA0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002100 ! KTNB1_HUMAN [Term] id: CCO:B0012648 name: KU70_HUMAN-N-acetylserine2 def: "Protein KU70_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P12956] comment: Potential xref: UniProtKB:P12956 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:B0012649 name: KU70_HUMAN-Phosphoserine6 def: "Protein KU70_HUMAN with the residue 6 substituted with Phosphoserine" [UniProtKB:P12956] comment: by PRKDC; xref: UniProtKB:P12956 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:B0012650 name: KU70_HUMAN-Phosphoserine27 def: "Protein KU70_HUMAN with the residue 27 substituted with Phosphoserine" [UniProtKB:P12956] xref: UniProtKB:P12956 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:B0012651 name: KU70_HUMAN-Phosphoserine51 def: "Protein KU70_HUMAN with the residue 51 substituted with Phosphoserine" [UniProtKB:P12956] comment: by PRKDC; xref: UniProtKB:P12956 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:B0012652 name: KU70_HUMAN-Phosphoserine222 def: "Protein KU70_HUMAN with the residue 222 substituted with Phosphoserine" [UniProtKB:P12956] xref: UniProtKB:P12956 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:B0012657 name: L2GL2_HUMAN-Phosphoserine664 def: "Protein L2GL2_HUMAN with the residue 664 substituted with Phosphoserine" [UniProtKB:Q6P1M3] xref: UniProtKB:Q6P1M3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001913 ! L2GL2_HUMAN [Term] id: CCO:B0012658 name: LAMA4_HUMAN-Phosphotyrosine1593 def: "Protein LAMA4_HUMAN with the residue 1593 substituted with Phosphotyrosine" [UniProtKB:Q16363] xref: UniProtKB:Q16363 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006093 ! LAMA4_HUMAN [Term] id: CCO:B0012659 name: LAP2_HUMAN-Phosphoserine440 def: "Protein LAP2_HUMAN with the residue 440 substituted with Phosphoserine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012660 name: LAP2_HUMAN-Phosphotyrosine483 def: "Protein LAP2_HUMAN with the residue 483 substituted with Phosphotyrosine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012661 name: LAP2_HUMAN-Phosphothreonine485 def: "Protein LAP2_HUMAN with the residue 485 substituted with Phosphothreonine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012662 name: LAP2_HUMAN-Phosphotyrosine487 def: "Protein LAP2_HUMAN with the residue 487 substituted with Phosphotyrosine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012663 name: LAP2_HUMAN-Phosphoserine598 def: "Protein LAP2_HUMAN with the residue 598 substituted with Phosphoserine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012664 name: LAP2_HUMAN-Phosphoserine602 def: "Protein LAP2_HUMAN with the residue 602 substituted with Phosphoserine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012665 name: LAP2_HUMAN-Phosphoserine603 def: "Protein LAP2_HUMAN with the residue 603 substituted with Phosphoserine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012666 name: LAP2_HUMAN-Phosphotyrosine733 def: "Protein LAP2_HUMAN with the residue 733 substituted with Phosphotyrosine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012667 name: LAP2_HUMAN-Phosphothreonine853 def: "Protein LAP2_HUMAN with the residue 853 substituted with Phosphothreonine" [UniProtKB:Q96RT1] comment: By similarity xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012668 name: LAP2_HUMAN-Phosphoserine857 def: "Protein LAP2_HUMAN with the residue 857 substituted with Phosphoserine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012669 name: LAP2_HUMAN-Phosphothreonine917 def: "Protein LAP2_HUMAN with the residue 917 substituted with Phosphothreonine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012670 name: LAP2_HUMAN-Phosphotyrosine920 def: "Protein LAP2_HUMAN with the residue 920 substituted with Phosphotyrosine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012671 name: LAP2_HUMAN-Phosphotyrosine972 def: "Protein LAP2_HUMAN with the residue 972 substituted with Phosphotyrosine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012672 name: LAP2_HUMAN-Phosphotyrosine981 def: "Protein LAP2_HUMAN with the residue 981 substituted with Phosphotyrosine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012673 name: LAP2_HUMAN-Phosphotyrosine1104 def: "Protein LAP2_HUMAN with the residue 1104 substituted with Phosphotyrosine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012674 name: LAP2_HUMAN-Phosphotyrosine1107 def: "Protein LAP2_HUMAN with the residue 1107 substituted with Phosphotyrosine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012675 name: LAP2_HUMAN-Phosphotyrosine1132 def: "Protein LAP2_HUMAN with the residue 1132 substituted with Phosphotyrosine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012676 name: LAP2_HUMAN-Phosphoserine1271 def: "Protein LAP2_HUMAN with the residue 1271 substituted with Phosphoserine" [UniProtKB:Q96RT1] xref: UniProtKB:Q96RT1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002059 ! LAP2_HUMAN [Term] id: CCO:B0012677 name: LATS1_HUMAN-Phosphoserine244 def: "Protein LATS1_HUMAN with the residue 244 substituted with Phosphoserine" [UniProtKB:O95835] xref: UniProtKB:O95835 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001454 ! LATS1_HUMAN [Term] id: CCO:B0012678 name: LATS1_HUMAN-Phosphoserine464 def: "Protein LATS1_HUMAN with the residue 464 substituted with Phosphoserine" [UniProtKB:O95835] comment: By similarity xref: UniProtKB:O95835 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001454 ! LATS1_HUMAN [Term] id: CCO:B0012679 name: LATS1_HUMAN-Phosphoserine674 def: "Protein LATS1_HUMAN with the residue 674 substituted with Phosphoserine" [UniProtKB:O95835] xref: UniProtKB:O95835 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001454 ! LATS1_HUMAN [Term] id: CCO:B0012680 name: LATS1_HUMAN-Phosphoserine909 def: "Protein LATS1_HUMAN with the residue 909 substituted with Phosphoserine" [UniProtKB:O95835] comment: by STK3; xref: UniProtKB:O95835 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0004210 ! protein kinase binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000144 ! spindle pole relationship: located_in CCO:C0000383 ! centrosome relationship: transformation_of CCO:B0001454 ! LATS1_HUMAN [Term] id: CCO:B0012681 name: LATS1_HUMAN-Phosphothreonine1079 def: "Protein LATS1_HUMAN with the residue 1079 substituted with Phosphothreonine" [UniProtKB:O95835] comment: by STK3; xref: UniProtKB:O95835 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001454 ! LATS1_HUMAN [Term] id: CCO:B0012682 name: LATS2_HUMAN-Phosphoserine83 def: "Protein LATS2_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:Q9NRM7] comment: by STK6; xref: UniProtKB:Q9NRM7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002159 ! LATS2_HUMAN [Term] id: CCO:B0012683 name: LC7L2_HUMAN-Phosphothreonine17 def: "Protein LC7L2_HUMAN with the residue 17 substituted with Phosphothreonine" [UniProtKB:Q9Y383] xref: UniProtKB:Q9Y383 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006150 ! LC7L2_HUMAN [Term] id: CCO:B0012684 name: LC7L2_HUMAN-Phosphoserine18 def: "Protein LC7L2_HUMAN with the residue 18 substituted with Phosphoserine" [UniProtKB:Q9Y383] xref: UniProtKB:Q9Y383 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006150 ! LC7L2_HUMAN [Term] id: CCO:B0012685 name: LC7L2_HUMAN-Phosphothreonine111 def: "Protein LC7L2_HUMAN with the residue 111 substituted with Phosphothreonine" [UniProtKB:Q9Y383] xref: UniProtKB:Q9Y383 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006150 ! LC7L2_HUMAN [Term] id: CCO:B0012686 name: LC7L2_HUMAN-Phosphoserine354 def: "Protein LC7L2_HUMAN with the residue 354 substituted with Phosphoserine" [UniProtKB:Q9Y383] xref: UniProtKB:Q9Y383 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006150 ! LC7L2_HUMAN [Term] id: CCO:B0012687 name: LC7L2_HUMAN-Phosphoserine358 def: "Protein LC7L2_HUMAN with the residue 358 substituted with Phosphoserine" [UniProtKB:Q9Y383] xref: UniProtKB:Q9Y383 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006150 ! LC7L2_HUMAN [Term] id: CCO:B0012688 name: LC7L2_HUMAN-Phosphoserine383 def: "Protein LC7L2_HUMAN with the residue 383 substituted with Phosphoserine" [UniProtKB:Q9Y383] comment: By similarity xref: UniProtKB:Q9Y383 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006150 ! LC7L2_HUMAN [Term] id: CCO:B0012689 name: LC7L2_HUMAN-Phosphoserine384 def: "Protein LC7L2_HUMAN with the residue 384 substituted with Phosphoserine" [UniProtKB:Q9Y383] comment: By similarity xref: UniProtKB:Q9Y383 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006150 ! LC7L2_HUMAN [Term] id: CCO:B0012690 name: LCK_HUMAN-Phosphoserine162 def: "Protein LCK_HUMAN with the residue 162 substituted with Phosphoserine" [UniProtKB:P06239] xref: UniProtKB:P06239 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001490 ! LCK_HUMAN [Term] id: CCO:B0012691 name: LCK_HUMAN-Phosphotyrosine192 def: "Protein LCK_HUMAN with the residue 192 substituted with Phosphotyrosine" [UniProtKB:P06239] xref: UniProtKB:P06239 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001490 ! LCK_HUMAN [Term] id: CCO:B0012692 name: LCK_HUMAN-Phosphoserine213 def: "Protein LCK_HUMAN with the residue 213 substituted with Phosphoserine" [UniProtKB:P06239] xref: UniProtKB:P06239 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001490 ! LCK_HUMAN [Term] id: CCO:B0012693 name: LCK_HUMAN-Phosphotyrosine394 def: "Protein LCK_HUMAN with the residue 394 substituted with Phosphotyrosine" [UniProtKB:P06239] comment: by autocatalysis; xref: UniProtKB:P06239 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001490 ! LCK_HUMAN [Term] id: CCO:B0012694 name: LCK_HUMAN-Phosphothreonine501 def: "Protein LCK_HUMAN with the residue 501 substituted with Phosphothreonine" [UniProtKB:P06239] xref: UniProtKB:P06239 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001490 ! LCK_HUMAN [Term] id: CCO:B0012695 name: LCK_HUMAN-Phosphotyrosine505 def: "Protein LCK_HUMAN with the residue 505 substituted with Phosphotyrosine" [UniProtKB:P06239] xref: UniProtKB:P06239 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001490 ! LCK_HUMAN [Term] id: CCO:B0012696 name: LEPR_HUMAN-Phosphotyrosine986 def: "Protein LEPR_HUMAN with the residue 986 substituted with Phosphotyrosine" [UniProtKB:P48357] comment: by JAK2; By similarity xref: UniProtKB:P48357 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005902 ! LEPR_HUMAN [Term] id: CCO:B0012697 name: LEPR_HUMAN-Phosphotyrosine1141 def: "Protein LEPR_HUMAN with the residue 1141 substituted with Phosphotyrosine" [UniProtKB:P48357] comment: by JAK2; By similarity xref: UniProtKB:P48357 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005902 ! LEPR_HUMAN [Term] id: CCO:B0012698 name: LIMK1_HUMAN-Phosphoserine298 def: "Protein LIMK1_HUMAN with the residue 298 substituted with Phosphoserine" [UniProtKB:P53667] xref: UniProtKB:P53667 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005606 ! LIMK1_HUMAN [Term] id: CCO:B0012699 name: LIMK1_HUMAN-Phosphoserine310 def: "Protein LIMK1_HUMAN with the residue 310 substituted with Phosphoserine" [UniProtKB:P53667] xref: UniProtKB:P53667 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005606 ! LIMK1_HUMAN [Term] id: CCO:B0012700 name: LIMK1_HUMAN-Phosphothreonine508 def: "Protein LIMK1_HUMAN with the residue 508 substituted with Phosphothreonine" [UniProtKB:P53667] comment: by ROCK1; xref: UniProtKB:P53667 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005606 ! LIMK1_HUMAN [Term] id: CCO:B0012701 name: LIN9_HUMAN-Phosphoserine309 def: "Protein LIN9_HUMAN with the residue 309 substituted with Phosphoserine" [UniProtKB:Q5TKA1] xref: UniProtKB:Q5TKA1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001894 ! LIN9_HUMAN [Term] id: CCO:B0012702 name: LIPA2_HUMAN-Phosphoserine538 def: "Protein LIPA2_HUMAN with the residue 538 substituted with Phosphoserine" [UniProtKB:O75334] comment: By similarity xref: UniProtKB:O75334 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005602 ! LIPA2_HUMAN [Term] id: CCO:B0012703 name: LIPA2_HUMAN-Phosphoserine689 def: "Protein LIPA2_HUMAN with the residue 689 substituted with Phosphoserine" [UniProtKB:O75334] comment: By similarity xref: UniProtKB:O75334 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005602 ! LIPA2_HUMAN [Term] id: CCO:B0012704 name: LIPA2_HUMAN-Phosphoserine774 def: "Protein LIPA2_HUMAN with the residue 774 substituted with Phosphoserine" [UniProtKB:O75334] comment: By similarity xref: UniProtKB:O75334 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005602 ! LIPA2_HUMAN [Term] id: CCO:B0012705 name: LPP3_HUMAN-Phosphotyrosine110 def: "Protein LPP3_HUMAN with the residue 110 substituted with Phosphotyrosine" [UniProtKB:O14495] xref: UniProtKB:O14495 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006019 ! LPP3_HUMAN [Term] id: CCO:B0012706 name: LSD1_HUMAN-Phosphoserine166 def: "Protein LSD1_HUMAN with the residue 166 substituted with Phosphoserine" [UniProtKB:O60341] xref: UniProtKB:O60341 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005589 ! LSD1_HUMAN [Term] id: CCO:B0012707 name: LSM3_HUMAN-N-acetylalanine2 def: "Protein LSM3_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P62310] xref: UniProtKB:P62310 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005566 ! LSM3_HUMAN [Term] id: CCO:B0012708 name: LSM8_HUMAN-N-acetylthreonine2 def: "Protein LSM8_HUMAN with the residue 2 substituted with N-acetylthreonine" [UniProtKB:O95777] xref: UniProtKB:O95777 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005349 ! LSM8_HUMAN [Term] id: CCO:B0012709 name: LYN_HUMAN-Phosphoserine11 def: "Protein LYN_HUMAN with the residue 11 substituted with Phosphoserine" [UniProtKB:P07948] xref: UniProtKB:P07948 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005457 ! LYN_HUMAN [Term] id: CCO:B0012710 name: LYN_HUMAN-Phosphoserine13 def: "Protein LYN_HUMAN with the residue 13 substituted with Phosphoserine" [UniProtKB:P07948] xref: UniProtKB:P07948 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005457 ! LYN_HUMAN [Term] id: CCO:B0012711 name: LYN_HUMAN-Phosphotyrosine397 def: "Protein LYN_HUMAN with the residue 397 substituted with Phosphotyrosine" [UniProtKB:P07948] comment: by autocatalysis; By similarity xref: UniProtKB:P07948 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005457 ! LYN_HUMAN [Term] id: CCO:B0012712 name: LYN_HUMAN-Phosphotyrosine508 def: "Protein LYN_HUMAN with the residue 508 substituted with Phosphotyrosine" [UniProtKB:P07948] xref: UniProtKB:P07948 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005457 ! LYN_HUMAN [Term] id: CCO:B0012713 name: M1IP1_HUMAN-Phosphoserine75 def: "Protein M1IP1_HUMAN with the residue 75 substituted with Phosphoserine" [UniProtKB:Q9NPA3] comment: By similarity xref: UniProtKB:Q9NPA3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005281 ! M1IP1_HUMAN [Term] id: CCO:B0012714 name: M2OM_HUMAN-N-acetylalanine2 def: "Protein M2OM_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q02978] xref: UniProtKB:Q02978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006316 ! M2OM_HUMAN [Term] id: CCO:B0012715 name: M3K11_HUMAN-Phosphothreonine277 def: "Protein M3K11_HUMAN with the residue 277 substituted with Phosphothreonine" [UniProtKB:Q16584] comment: by autocatalysis; xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012716 name: M3K11_HUMAN-Phosphoserine281 def: "Protein M3K11_HUMAN with the residue 281 substituted with Phosphoserine" [UniProtKB:Q16584] comment: by autocatalysis and MAP4K1; xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012717 name: M3K11_HUMAN-Phosphoserine507 def: "Protein M3K11_HUMAN with the residue 507 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012718 name: M3K11_HUMAN-Phosphoserine524 def: "Protein M3K11_HUMAN with the residue 524 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012719 name: M3K11_HUMAN-Phosphoserine555 def: "Protein M3K11_HUMAN with the residue 555 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012720 name: M3K11_HUMAN-Phosphoserine556 def: "Protein M3K11_HUMAN with the residue 556 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012721 name: M3K11_HUMAN-Phosphoserine654 def: "Protein M3K11_HUMAN with the residue 654 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012722 name: M3K11_HUMAN-Phosphoserine705 def: "Protein M3K11_HUMAN with the residue 705 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012723 name: M3K11_HUMAN-Phosphoserine724 def: "Protein M3K11_HUMAN with the residue 724 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012724 name: M3K11_HUMAN-Phosphoserine727 def: "Protein M3K11_HUMAN with the residue 727 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012725 name: M3K11_HUMAN-Phosphothreonine738 def: "Protein M3K11_HUMAN with the residue 738 substituted with Phosphothreonine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012726 name: M3K11_HUMAN-Phosphoserine740 def: "Protein M3K11_HUMAN with the residue 740 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001072 ! JUN kinase kinase kinase activity relationship: has_function CCO:F0001075 ! MAP kinase kinase kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0005714 ! protein homodimerization activity relationship: has_function CCO:F0008374 ! protein tyrosine kinase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000434 ! microtubule relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012727 name: M3K11_HUMAN-Phosphoserine746 def: "Protein M3K11_HUMAN with the residue 746 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012728 name: M3K11_HUMAN-Phosphoserine758 def: "Protein M3K11_HUMAN with the residue 758 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012729 name: M3K11_HUMAN-Phosphoserine770 def: "Protein M3K11_HUMAN with the residue 770 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012730 name: M3K11_HUMAN-Phosphoserine793 def: "Protein M3K11_HUMAN with the residue 793 substituted with Phosphoserine" [UniProtKB:Q16584] xref: UniProtKB:Q16584 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001820 ! M3K11_HUMAN [Term] id: CCO:B0012731 name: M3K1_HUMAN-Phosphothreonine1402 def: "Protein M3K1_HUMAN with the residue 1402 substituted with Phosphothreonine" [UniProtKB:Q13233] comment: by autocatalysis; By similarity xref: UniProtKB:Q13233 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005525 ! M3K1_HUMAN [Term] id: CCO:B0012732 name: M3K1_HUMAN-Phosphothreonine1414 def: "Protein M3K1_HUMAN with the residue 1414 substituted with Phosphothreonine" [UniProtKB:Q13233] comment: by autocatalysis; By similarity xref: UniProtKB:Q13233 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005525 ! M3K1_HUMAN [Term] id: CCO:B0012733 name: M3K3_HUMAN-Phosphotyrosine288 def: "Protein M3K3_HUMAN with the residue 288 substituted with Phosphotyrosine" [UniProtKB:Q99759] xref: UniProtKB:Q99759 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:B0012734 name: M3K3_HUMAN-Phosphoserine289 def: "Protein M3K3_HUMAN with the residue 289 substituted with Phosphoserine" [UniProtKB:Q99759] xref: UniProtKB:Q99759 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:B0012735 name: M3K3_HUMAN-Phosphothreonine294 def: "Protein M3K3_HUMAN with the residue 294 substituted with Phosphothreonine" [UniProtKB:Q99759] xref: UniProtKB:Q99759 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:B0012736 name: M3K3_HUMAN-Phosphoserine337 def: "Protein M3K3_HUMAN with the residue 337 substituted with Phosphoserine" [UniProtKB:Q99759] comment: By similarity xref: UniProtKB:Q99759 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:B0012737 name: M3K3_HUMAN-Phosphoserine340 def: "Protein M3K3_HUMAN with the residue 340 substituted with Phosphoserine" [UniProtKB:Q99759] comment: By similarity xref: UniProtKB:Q99759 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:B0012738 name: M3K3_HUMAN-Phosphothreonine530 def: "Protein M3K3_HUMAN with the residue 530 substituted with Phosphothreonine" [UniProtKB:Q99759] comment: By similarity xref: UniProtKB:Q99759 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:B0012739 name: M3K4_HUMAN-Phosphoserine499 def: "Protein M3K4_HUMAN with the residue 499 substituted with Phosphoserine" [UniProtKB:Q9Y6R4] comment: By similarity xref: UniProtKB:Q9Y6R4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005915 ! M3K4_HUMAN [Term] id: CCO:B0012740 name: M3K4_HUMAN-Phosphothreonine1504 def: "Protein M3K4_HUMAN with the residue 1504 substituted with Phosphothreonine" [UniProtKB:Q9Y6R4] comment: By similarity xref: UniProtKB:Q9Y6R4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005915 ! M3K4_HUMAN [Term] id: CCO:B0012745 name: M4K2_HUMAN-Phosphoserine327 def: "Protein M4K2_HUMAN with the residue 327 substituted with Phosphoserine" [UniProtKB:Q12851] xref: UniProtKB:Q12851 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005706 ! M4K2_HUMAN [Term] id: CCO:B0012746 name: MACF1_HUMAN-Phosphoserine280 def: "Protein MACF1_HUMAN with the residue 280 substituted with Phosphoserine" [UniProtKB:Q9UPN3] comment: By similarity xref: UniProtKB:Q9UPN3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002237 ! MACF1_HUMAN [Term] id: CCO:B0012747 name: MACF1_HUMAN-Phosphoserine1860 def: "Protein MACF1_HUMAN with the residue 1860 substituted with Phosphoserine" [UniProtKB:Q9UPN3] xref: UniProtKB:Q9UPN3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002237 ! MACF1_HUMAN [Term] id: CCO:B0012748 name: MACF1_HUMAN-Phosphoserine2454 def: "Protein MACF1_HUMAN with the residue 2454 substituted with Phosphoserine" [UniProtKB:Q9UPN3] xref: UniProtKB:Q9UPN3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002237 ! MACF1_HUMAN [Term] id: CCO:B0012749 name: MACF1_HUMAN-Phosphoserine4074 def: "Protein MACF1_HUMAN with the residue 4074 substituted with Phosphoserine" [UniProtKB:Q9UPN3] comment: By similarity xref: UniProtKB:Q9UPN3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002237 ! MACF1_HUMAN [Term] id: CCO:B0012750 name: MACF1_HUMAN-Phosphoserine5372 def: "Protein MACF1_HUMAN with the residue 5372 substituted with Phosphoserine" [UniProtKB:Q9UPN3] comment: By similarity xref: UniProtKB:Q9UPN3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002237 ! MACF1_HUMAN [Term] id: CCO:B0012751 name: MACF1_HUMAN-Phosphoserine5375 def: "Protein MACF1_HUMAN with the residue 5375 substituted with Phosphoserine" [UniProtKB:Q9UPN3] comment: By similarity xref: UniProtKB:Q9UPN3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002237 ! MACF1_HUMAN [Term] id: CCO:B0012752 name: MACF4_HUMAN-Phosphoserine2576 def: "Protein MACF4_HUMAN with the residue 2576 substituted with Phosphoserine" [UniProtKB:Q96PK2] xref: UniProtKB:Q96PK2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002053 ! MACF4_HUMAN [Term] id: CCO:B0012753 name: MACF4_HUMAN-Phosphoserine2577 def: "Protein MACF4_HUMAN with the residue 2577 substituted with Phosphoserine" [UniProtKB:Q96PK2] xref: UniProtKB:Q96PK2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002053 ! MACF4_HUMAN [Term] id: CCO:B0012754 name: MACF4_HUMAN-Phosphoserine2579 def: "Protein MACF4_HUMAN with the residue 2579 substituted with Phosphoserine" [UniProtKB:Q96PK2] xref: UniProtKB:Q96PK2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002053 ! MACF4_HUMAN [Term] id: CCO:B0012755 name: MACF4_HUMAN-Phosphothreonine5627 def: "Protein MACF4_HUMAN with the residue 5627 substituted with Phosphothreonine" [UniProtKB:Q96PK2] xref: UniProtKB:Q96PK2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002053 ! MACF4_HUMAN [Term] id: CCO:B0012756 name: MACF4_HUMAN-Phosphothreonine5823 def: "Protein MACF4_HUMAN with the residue 5823 substituted with Phosphothreonine" [UniProtKB:Q96PK2] xref: UniProtKB:Q96PK2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002053 ! MACF4_HUMAN [Term] id: CCO:B0012757 name: MADD_HUMAN-Phosphoserine1059 def: "Protein MADD_HUMAN with the residue 1059 substituted with Phosphoserine" [UniProtKB:Q8WXG6] comment: By similarity xref: UniProtKB:Q8WXG6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001390 ! guanyl-nucleotide exchange factor activity relationship: has_function CCO:F0001425 ! death receptor binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003575 ! Rab guanyl-nucleotide exchange factor activity relationship: has_function CCO:F0004382 ! protein kinase activator activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: transformation_of CCO:B0002010 ! MADD_HUMAN [Term] id: CCO:B0012758 name: MADD_HUMAN-Phosphothreonine1061 def: "Protein MADD_HUMAN with the residue 1061 substituted with Phosphothreonine" [UniProtKB:Q8WXG6] comment: By similarity xref: UniProtKB:Q8WXG6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002010 ! MADD_HUMAN [Term] id: CCO:B0012759 name: MAF1_HUMAN-Phosphoserine75 def: "Protein MAF1_HUMAN with the residue 75 substituted with Phosphoserine" [UniProtKB:Q9H063] xref: UniProtKB:Q9H063 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005301 ! MAF1_HUMAN [Term] id: CCO:B0012760 name: MAGAB_HUMAN-Phosphoserine76 def: "Protein MAGAB_HUMAN with the residue 76 substituted with Phosphoserine" [UniProtKB:P43364] xref: UniProtKB:P43364 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005212 ! MAGAB_HUMAN [Term] id: CCO:B0012761 name: MAP9_HUMAN-Phosphoserine132 def: "Protein MAP9_HUMAN with the residue 132 substituted with Phosphoserine" [UniProtKB:Q49MG5] xref: UniProtKB:Q49MG5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001834 ! MAP9_HUMAN [Term] id: CCO:B0012762 name: MAPK5_HUMAN-Phosphothreonine182 def: "Protein MAPK5_HUMAN with the residue 182 substituted with Phosphothreonine" [UniProtKB:Q8IW41] xref: UniProtKB:Q8IW41 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005891 ! MAPK5_HUMAN [Term] id: CCO:B0012763 name: MARE1_HUMAN-N-acetylalanine2 def: "Protein MARE1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q15691] xref: UniProtKB:Q15691 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001812 ! MARE1_HUMAN [Term] id: CCO:B0012764 name: MARE1_HUMAN-Phosphotyrosine124 def: "Protein MARE1_HUMAN with the residue 124 substituted with Phosphotyrosine" [UniProtKB:Q15691] xref: UniProtKB:Q15691 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001812 ! MARE1_HUMAN [Term] id: CCO:B0012765 name: MARE1_HUMAN-Phosphoserine155 def: "Protein MARE1_HUMAN with the residue 155 substituted with Phosphoserine" [UniProtKB:Q15691] xref: UniProtKB:Q15691 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001812 ! MARE1_HUMAN [Term] id: CCO:B0012766 name: MARE1_HUMAN-Phosphothreonine166 def: "Protein MARE1_HUMAN with the residue 166 substituted with Phosphothreonine" [UniProtKB:Q15691] xref: UniProtKB:Q15691 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001812 ! MARE1_HUMAN [Term] id: CCO:B0012767 name: MARE2_HUMAN-Phosphotyrosine167 def: "Protein MARE2_HUMAN with the residue 167 substituted with Phosphotyrosine" [UniProtKB:Q15555] xref: UniProtKB:Q15555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001811 ! MARE2_HUMAN [Term] id: CCO:B0012768 name: MARE2_HUMAN-Phosphoserine200 def: "Protein MARE2_HUMAN with the residue 200 substituted with Phosphoserine" [UniProtKB:Q15555] xref: UniProtKB:Q15555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001811 ! MARE2_HUMAN [Term] id: CCO:B0012769 name: MARE2_HUMAN-Phosphoserine219 def: "Protein MARE2_HUMAN with the residue 219 substituted with Phosphoserine" [UniProtKB:Q15555] xref: UniProtKB:Q15555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001811 ! MARE2_HUMAN [Term] id: CCO:B0012770 name: MARE2_HUMAN-Phosphoserine223 def: "Protein MARE2_HUMAN with the residue 223 substituted with Phosphoserine" [UniProtKB:Q15555] xref: UniProtKB:Q15555 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001811 ! MARE2_HUMAN [Term] id: CCO:B0012771 name: MARE3_HUMAN-Phosphothreonine161 def: "Protein MARE3_HUMAN with the residue 161 substituted with Phosphothreonine" [UniProtKB:Q9UPY8] comment: By similarity xref: UniProtKB:Q9UPY8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002238 ! MARE3_HUMAN [Term] id: CCO:B0012776 name: MARK4_HUMAN-Phosphoserine26 def: "Protein MARK4_HUMAN with the residue 26 substituted with Phosphoserine" [UniProtKB:Q96L34] xref: UniProtKB:Q96L34 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005344 ! MARK4_HUMAN [Term] id: CCO:B0012777 name: MARK4_HUMAN-Phosphothreonine214 def: "Protein MARK4_HUMAN with the residue 214 substituted with Phosphothreonine" [UniProtKB:Q96L34] xref: UniProtKB:Q96L34 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005344 ! MARK4_HUMAN [Term] id: CCO:B0012778 name: MAST3_HUMAN-Phosphoserine1223 def: "Protein MAST3_HUMAN with the residue 1223 substituted with Phosphoserine" [UniProtKB:O60307] comment: By similarity xref: UniProtKB:O60307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005499 ! MAST3_HUMAN [Term] id: CCO:B0012779 name: MAST3_HUMAN-Phosphoserine1273 def: "Protein MAST3_HUMAN with the residue 1273 substituted with Phosphoserine" [UniProtKB:O60307] comment: By similarity xref: UniProtKB:O60307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005499 ! MAST3_HUMAN [Term] id: CCO:B0012782 name: MATR3_HUMAN-Phosphoserine188 def: "Protein MATR3_HUMAN with the residue 188 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012783 name: MATR3_HUMAN-Phosphoserine195 def: "Protein MATR3_HUMAN with the residue 195 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012784 name: MATR3_HUMAN-Phosphoserine208 def: "Protein MATR3_HUMAN with the residue 208 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012785 name: MATR3_HUMAN-Phosphoserine397 def: "Protein MATR3_HUMAN with the residue 397 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012786 name: MATR3_HUMAN-Phosphoserine596 def: "Protein MATR3_HUMAN with the residue 596 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012787 name: MATR3_HUMAN-Phosphoserine598 def: "Protein MATR3_HUMAN with the residue 598 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012788 name: MATR3_HUMAN-Phosphoserine604 def: "Protein MATR3_HUMAN with the residue 604 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012789 name: MATR3_HUMAN-Phosphoserine654 def: "Protein MATR3_HUMAN with the residue 654 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012790 name: MATR3_HUMAN-Phosphoserine671 def: "Protein MATR3_HUMAN with the residue 671 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012791 name: MATR3_HUMAN-Phosphoserine673 def: "Protein MATR3_HUMAN with the residue 673 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012792 name: MATR3_HUMAN-Phosphoserine674 def: "Protein MATR3_HUMAN with the residue 674 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012793 name: MATR3_HUMAN-Phosphoserine696 def: "Protein MATR3_HUMAN with the residue 696 substituted with Phosphoserine" [UniProtKB:P43243] xref: UniProtKB:P43243 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:B0012794 name: MAX_HUMAN-Phosphoserine2 def: "Protein MAX_HUMAN with the residue 2 substituted with Phosphoserine" [UniProtKB:P61244] xref: UniProtKB:P61244 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005336 ! MAX_HUMAN [Term] id: CCO:B0012795 name: MAX_HUMAN-Phosphoserine11 def: "Protein MAX_HUMAN with the residue 11 substituted with Phosphoserine" [UniProtKB:P61244] xref: UniProtKB:P61244 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005336 ! MAX_HUMAN [Term] id: CCO:B0012796 name: MAX_HUMAN-N6-acetyllysine66 def: "Protein MAX_HUMAN with the residue 66 substituted with N6-acetyllysine" [UniProtKB:P61244] comment: Probable xref: UniProtKB:P61244 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005336 ! MAX_HUMAN [Term] id: CCO:B0012797 name: MAX_HUMAN-Phosphotyrosine123 def: "Protein MAX_HUMAN with the residue 123 substituted with Phosphotyrosine" [UniProtKB:P61244] xref: UniProtKB:P61244 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005336 ! MAX_HUMAN [Term] id: CCO:B0012798 name: MAX_HUMAN-N6-acetyllysine153 def: "Protein MAX_HUMAN with the residue 153 substituted with N6-acetyllysine" [UniProtKB:P61244] comment: alternate; xref: UniProtKB:P61244 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005336 ! MAX_HUMAN [Term] id: CCO:B0012799 name: MAX_HUMAN-N6-acetyllysine154 def: "Protein MAX_HUMAN with the residue 154 substituted with N6-acetyllysine" [UniProtKB:P61244] comment: alternate; xref: UniProtKB:P61244 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005336 ! MAX_HUMAN [Term] id: CCO:B0012800 name: MBD1_HUMAN-Phosphotyrosine52 def: "Protein MBD1_HUMAN with the residue 52 substituted with Phosphotyrosine" [UniProtKB:Q9UIS9] xref: UniProtKB:Q9UIS9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005510 ! MBD1_HUMAN [Term] id: CCO:B0012801 name: MBD1_HUMAN-Phosphoserine295 def: "Protein MBD1_HUMAN with the residue 295 substituted with Phosphoserine" [UniProtKB:Q9UIS9] xref: UniProtKB:Q9UIS9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005510 ! MBD1_HUMAN [Term] id: CCO:B0012802 name: MBD1_HUMAN-Phosphothreonine301 def: "Protein MBD1_HUMAN with the residue 301 substituted with Phosphothreonine" [UniProtKB:Q9UIS9] xref: UniProtKB:Q9UIS9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005510 ! MBD1_HUMAN [Term] id: CCO:B0012803 name: MCM10_HUMAN-Phosphothreonine85 def: "Protein MCM10_HUMAN with the residue 85 substituted with Phosphothreonine" [UniProtKB:Q7L590] xref: UniProtKB:Q7L590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:B0012804 name: MCM10_HUMAN-Phosphoserine93 def: "Protein MCM10_HUMAN with the residue 93 substituted with Phosphoserine" [UniProtKB:Q7L590] xref: UniProtKB:Q7L590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:B0012805 name: MCM2_HUMAN-Phosphoserine13 def: "Protein MCM2_HUMAN with the residue 13 substituted with Phosphoserine" [UniProtKB:P49736] xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0012806 name: MCM2_HUMAN-Phosphoserine26 def: "Protein MCM2_HUMAN with the residue 26 substituted with Phosphoserine" [UniProtKB:P49736] xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0012807 name: MCM2_HUMAN-Phosphoserine27 def: "Protein MCM2_HUMAN with the residue 27 substituted with Phosphoserine" [UniProtKB:P49736] xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0012808 name: MCM2_HUMAN-Phosphothreonine39 def: "Protein MCM2_HUMAN with the residue 39 substituted with Phosphothreonine" [UniProtKB:P49736] xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0012809 name: MCM2_HUMAN-Phosphoserine40 def: "Protein MCM2_HUMAN with the residue 40 substituted with Phosphoserine" [UniProtKB:P49736] comment: by CDC7; xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0012810 name: MCM2_HUMAN-Phosphoserine41 def: "Protein MCM2_HUMAN with the residue 41 substituted with Phosphoserine" [UniProtKB:P49736] xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0012811 name: MCM2_HUMAN-Phosphothreonine106 def: "Protein MCM2_HUMAN with the residue 106 substituted with Phosphothreonine" [UniProtKB:P49736] xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0012812 name: MCM2_HUMAN-Phosphoserine108 def: "Protein MCM2_HUMAN with the residue 108 substituted with Phosphoserine" [UniProtKB:P49736] comment: by ATR; xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0012813 name: MCM2_HUMAN-Phosphoserine139 def: "Protein MCM2_HUMAN with the residue 139 substituted with Phosphoserine" [UniProtKB:P49736] xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0012814 name: MCM3_HUMAN-N-acetylalanine2 def: "Protein MCM3_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012815 name: MCM3_HUMAN-Phosphoserine535 def: "Protein MCM3_HUMAN with the residue 535 substituted with Phosphoserine" [UniProtKB:P25205] comment: by ATM; xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012816 name: MCM3_HUMAN-Phosphoserine668 def: "Protein MCM3_HUMAN with the residue 668 substituted with Phosphoserine" [UniProtKB:P25205] comment: By similarity xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012817 name: MCM3_HUMAN-Phosphoserine672 def: "Protein MCM3_HUMAN with the residue 672 substituted with Phosphoserine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012818 name: MCM3_HUMAN-Phosphothreonine674 def: "Protein MCM3_HUMAN with the residue 674 substituted with Phosphothreonine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012819 name: MCM3_HUMAN-Phosphoserine681 def: "Protein MCM3_HUMAN with the residue 681 substituted with Phosphoserine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012820 name: MCM3_HUMAN-Phosphoserine704 def: "Protein MCM3_HUMAN with the residue 704 substituted with Phosphoserine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012821 name: MCM3_HUMAN-Phosphoserine711 def: "Protein MCM3_HUMAN with the residue 711 substituted with Phosphoserine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012822 name: MCM3_HUMAN-Phosphothreonine713 def: "Protein MCM3_HUMAN with the residue 713 substituted with Phosphothreonine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012823 name: MCM3_HUMAN-Phosphothreonine722 def: "Protein MCM3_HUMAN with the residue 722 substituted with Phosphothreonine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012824 name: MCM3_HUMAN-Phosphoserine728 def: "Protein MCM3_HUMAN with the residue 728 substituted with Phosphoserine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012825 name: MCM3_HUMAN-Phosphoserine734 def: "Protein MCM3_HUMAN with the residue 734 substituted with Phosphoserine" [UniProtKB:P25205] xref: UniProtKB:P25205 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:B0012826 name: MCM4_HUMAN-Phosphothreonine19 def: "Protein MCM4_HUMAN with the residue 19 substituted with Phosphothreonine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012827 name: MCM4_HUMAN-Phosphoserine26 def: "Protein MCM4_HUMAN with the residue 26 substituted with Phosphoserine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012828 name: MCM4_HUMAN-Phosphoserine32 def: "Protein MCM4_HUMAN with the residue 32 substituted with Phosphoserine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012829 name: MCM4_HUMAN-Phosphoserine105 def: "Protein MCM4_HUMAN with the residue 105 substituted with Phosphoserine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012830 name: MCM4_HUMAN-Phosphothreonine110 def: "Protein MCM4_HUMAN with the residue 110 substituted with Phosphothreonine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012831 name: MCM4_HUMAN-Phosphoserine120 def: "Protein MCM4_HUMAN with the residue 120 substituted with Phosphoserine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012832 name: MCM4_HUMAN-Phosphoserine131 def: "Protein MCM4_HUMAN with the residue 131 substituted with Phosphoserine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012833 name: MCM4_HUMAN-Phosphoserine142 def: "Protein MCM4_HUMAN with the residue 142 substituted with Phosphoserine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012834 name: MCM4_HUMAN-Phosphoserine145 def: "Protein MCM4_HUMAN with the residue 145 substituted with Phosphoserine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012835 name: MCM4_HUMAN-Phosphoserine326 def: "Protein MCM4_HUMAN with the residue 326 substituted with Phosphoserine" [UniProtKB:P33991] xref: UniProtKB:P33991 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:B0012836 name: MCM6_HUMAN-Phosphoserine271 def: "Protein MCM6_HUMAN with the residue 271 substituted with Phosphoserine" [UniProtKB:Q14566] xref: UniProtKB:Q14566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:B0012837 name: MCM6_HUMAN-Phosphoserine762 def: "Protein MCM6_HUMAN with the residue 762 substituted with Phosphoserine" [UniProtKB:Q14566] xref: UniProtKB:Q14566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:B0012838 name: MCM6_HUMAN-Phosphothreonine791 def: "Protein MCM6_HUMAN with the residue 791 substituted with Phosphothreonine" [UniProtKB:Q14566] xref: UniProtKB:Q14566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:B0012839 name: MCM7_HUMAN-Phosphoserine549 def: "Protein MCM7_HUMAN with the residue 549 substituted with Phosphoserine" [UniProtKB:P33993] xref: UniProtKB:P33993 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001589 ! MCM7_HUMAN [Term] id: CCO:B0012840 name: MCRS1_HUMAN-Phosphothreonine103 def: "Protein MCRS1_HUMAN with the residue 103 substituted with Phosphothreonine" [UniProtKB:Q96EZ8] xref: UniProtKB:Q96EZ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002036 ! MCRS1_HUMAN [Term] id: CCO:B0012841 name: MCRS1_HUMAN-Phosphoserine108 def: "Protein MCRS1_HUMAN with the residue 108 substituted with Phosphoserine" [UniProtKB:Q96EZ8] xref: UniProtKB:Q96EZ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002036 ! MCRS1_HUMAN [Term] id: CCO:B0012842 name: MCRS1_HUMAN-Phosphoserine282 def: "Protein MCRS1_HUMAN with the residue 282 substituted with Phosphoserine" [UniProtKB:Q96EZ8] xref: UniProtKB:Q96EZ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002036 ! MCRS1_HUMAN [Term] id: CCO:B0012844 name: MD1L1_HUMAN-Phosphoserine214 def: "Protein MD1L1_HUMAN with the residue 214 substituted with Phosphoserine" [UniProtKB:Q9Y6D9] xref: UniProtKB:Q9Y6D9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002264 ! MD1L1_HUMAN [Term] id: CCO:B0012845 name: MD1L1_HUMAN-Phosphoserine428 def: "Protein MD1L1_HUMAN with the residue 428 substituted with Phosphoserine" [UniProtKB:Q9Y6D9] xref: UniProtKB:Q9Y6D9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002264 ! MD1L1_HUMAN [Term] id: CCO:B0012846 name: MD2BP_HUMAN-Phosphoserine29 def: "Protein MD2BP_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:Q15013] xref: UniProtKB:Q15013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001799 ! MD2BP_HUMAN [Term] id: CCO:B0012847 name: MD2BP_HUMAN-Phosphothreonine39 def: "Protein MD2BP_HUMAN with the residue 39 substituted with Phosphothreonine" [UniProtKB:Q15013] xref: UniProtKB:Q15013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001799 ! MD2BP_HUMAN [Term] id: CCO:B0012848 name: MDC1_HUMAN-Phosphoserine168 def: "Protein MDC1_HUMAN with the residue 168 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012849 name: MDC1_HUMAN-Phosphoserine329 def: "Protein MDC1_HUMAN with the residue 329 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012850 name: MDC1_HUMAN-Phosphothreonine331 def: "Protein MDC1_HUMAN with the residue 331 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012851 name: MDC1_HUMAN-Phosphoserine372 def: "Protein MDC1_HUMAN with the residue 372 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012852 name: MDC1_HUMAN-Phosphoserine376 def: "Protein MDC1_HUMAN with the residue 376 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012853 name: MDC1_HUMAN-Phosphothreonine378 def: "Protein MDC1_HUMAN with the residue 378 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012854 name: MDC1_HUMAN-Phosphoserine402 def: "Protein MDC1_HUMAN with the residue 402 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012855 name: MDC1_HUMAN-Phosphothreonine404 def: "Protein MDC1_HUMAN with the residue 404 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012856 name: MDC1_HUMAN-Phosphoserine422 def: "Protein MDC1_HUMAN with the residue 422 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012857 name: MDC1_HUMAN-Phosphoserine453 def: "Protein MDC1_HUMAN with the residue 453 substituted with Phosphoserine" [UniProtKB:Q14676] comment: By similarity xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012858 name: MDC1_HUMAN-Phosphothreonine455 def: "Protein MDC1_HUMAN with the residue 455 substituted with Phosphothreonine" [UniProtKB:Q14676] comment: By similarity xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012859 name: MDC1_HUMAN-Phosphoserine495 def: "Protein MDC1_HUMAN with the residue 495 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012860 name: MDC1_HUMAN-Phosphoserine498 def: "Protein MDC1_HUMAN with the residue 498 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012861 name: MDC1_HUMAN-Phosphoserine513 def: "Protein MDC1_HUMAN with the residue 513 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012862 name: MDC1_HUMAN-Phosphoserine516 def: "Protein MDC1_HUMAN with the residue 516 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012863 name: MDC1_HUMAN-Phosphothreonine523 def: "Protein MDC1_HUMAN with the residue 523 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012864 name: MDC1_HUMAN-Phosphothreonine652 def: "Protein MDC1_HUMAN with the residue 652 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012865 name: MDC1_HUMAN-Phosphothreonine659 def: "Protein MDC1_HUMAN with the residue 659 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012866 name: MDC1_HUMAN-Phosphoserine763 def: "Protein MDC1_HUMAN with the residue 763 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012867 name: MDC1_HUMAN-Phosphothreonine765 def: "Protein MDC1_HUMAN with the residue 765 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012868 name: MDC1_HUMAN-Phosphoserine780 def: "Protein MDC1_HUMAN with the residue 780 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012869 name: MDC1_HUMAN-Phosphoserine882 def: "Protein MDC1_HUMAN with the residue 882 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012870 name: MDC1_HUMAN-Phosphoserine955 def: "Protein MDC1_HUMAN with the residue 955 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012871 name: MDC1_HUMAN-Phosphoserine964 def: "Protein MDC1_HUMAN with the residue 964 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012872 name: MDC1_HUMAN-Phosphoserine986 def: "Protein MDC1_HUMAN with the residue 986 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012873 name: MDC1_HUMAN-Phosphoserine988 def: "Protein MDC1_HUMAN with the residue 988 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012874 name: MDC1_HUMAN-Phosphoserine995 def: "Protein MDC1_HUMAN with the residue 995 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012875 name: MDC1_HUMAN-Phosphoserine1068 def: "Protein MDC1_HUMAN with the residue 1068 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012876 name: MDC1_HUMAN-Phosphoserine1086 def: "Protein MDC1_HUMAN with the residue 1086 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012877 name: MDC1_HUMAN-Phosphoserine1095 def: "Protein MDC1_HUMAN with the residue 1095 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012878 name: MDC1_HUMAN-Phosphothreonine1425 def: "Protein MDC1_HUMAN with the residue 1425 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012879 name: MDC1_HUMAN-Phosphoserine1430 def: "Protein MDC1_HUMAN with the residue 1430 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012880 name: MDC1_HUMAN-Phosphothreonine1461 def: "Protein MDC1_HUMAN with the residue 1461 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012881 name: MDC1_HUMAN-Phosphothreonine1623 def: "Protein MDC1_HUMAN with the residue 1623 substituted with Phosphothreonine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012882 name: MDC1_HUMAN-Phosphoserine1797 def: "Protein MDC1_HUMAN with the residue 1797 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012883 name: MDC1_HUMAN-Phosphoserine1814 def: "Protein MDC1_HUMAN with the residue 1814 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012884 name: MDC1_HUMAN-Phosphoserine1820 def: "Protein MDC1_HUMAN with the residue 1820 substituted with Phosphoserine" [UniProtKB:Q14676] xref: UniProtKB:Q14676 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:B0012910 name: MERL_HUMAN-Phosphoserine518 def: "Protein MERL_HUMAN with the residue 518 substituted with Phosphoserine" [UniProtKB:P35240] xref: UniProtKB:P35240 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001592 ! MERL_HUMAN [Term] id: CCO:B0012911 name: MET_HUMAN-Phosphothreonine977 def: "Protein MET_HUMAN with the residue 977 substituted with Phosphothreonine" [UniProtKB:P08581] xref: UniProtKB:P08581 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005438 ! MET_HUMAN [Term] id: CCO:B0012912 name: MET_HUMAN-Phosphoserine988 def: "Protein MET_HUMAN with the residue 988 substituted with Phosphoserine" [UniProtKB:P08581] xref: UniProtKB:P08581 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005438 ! MET_HUMAN [Term] id: CCO:B0012913 name: MET_HUMAN-Phosphoserine990 def: "Protein MET_HUMAN with the residue 990 substituted with Phosphoserine" [UniProtKB:P08581] xref: UniProtKB:P08581 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005438 ! MET_HUMAN [Term] id: CCO:B0012914 name: MET_HUMAN-Phosphotyrosine1003 def: "Protein MET_HUMAN with the residue 1003 substituted with Phosphotyrosine" [UniProtKB:P08581] xref: UniProtKB:P08581 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005438 ! MET_HUMAN [Term] id: CCO:B0012915 name: MET_HUMAN-Phosphotyrosine1235 def: "Protein MET_HUMAN with the residue 1235 substituted with Phosphotyrosine" [UniProtKB:P08581] comment: by autocatalysis; xref: UniProtKB:P08581 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005438 ! MET_HUMAN [Term] id: CCO:B0012916 name: MET_HUMAN-Phosphotyrosine1356 def: "Protein MET_HUMAN with the residue 1356 substituted with Phosphotyrosine" [UniProtKB:P08581] xref: UniProtKB:P08581 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005438 ! MET_HUMAN [Term] id: CCO:B0012917 name: MINT_HUMAN-Phosphoserine260 def: "Protein MINT_HUMAN with the residue 260 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012918 name: MINT_HUMAN-Phosphoserine263 def: "Protein MINT_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012919 name: MINT_HUMAN-Phosphothreonine266 def: "Protein MINT_HUMAN with the residue 266 substituted with Phosphothreonine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012920 name: MINT_HUMAN-Phosphoserine725 def: "Protein MINT_HUMAN with the residue 725 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012921 name: MINT_HUMAN-Phosphoserine727 def: "Protein MINT_HUMAN with the residue 727 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012922 name: MINT_HUMAN-Phosphoserine736 def: "Protein MINT_HUMAN with the residue 736 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012923 name: MINT_HUMAN-Phosphoserine740 def: "Protein MINT_HUMAN with the residue 740 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012924 name: MINT_HUMAN-Phosphoserine1261 def: "Protein MINT_HUMAN with the residue 1261 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012925 name: MINT_HUMAN-Phosphoserine1268 def: "Protein MINT_HUMAN with the residue 1268 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012926 name: MINT_HUMAN-Phosphoserine1278 def: "Protein MINT_HUMAN with the residue 1278 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012927 name: MINT_HUMAN-Phosphoserine1283 def: "Protein MINT_HUMAN with the residue 1283 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012928 name: MINT_HUMAN-Phosphoserine1380 def: "Protein MINT_HUMAN with the residue 1380 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012929 name: MINT_HUMAN-Phosphoserine1382 def: "Protein MINT_HUMAN with the residue 1382 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012930 name: MINT_HUMAN-Phosphothreonine1619 def: "Protein MINT_HUMAN with the residue 1619 substituted with Phosphothreonine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012931 name: MINT_HUMAN-Phosphoserine1797 def: "Protein MINT_HUMAN with the residue 1797 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012932 name: MINT_HUMAN-Phosphoserine1857 def: "Protein MINT_HUMAN with the residue 1857 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012933 name: MINT_HUMAN-Phosphoserine2101 def: "Protein MINT_HUMAN with the residue 2101 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012934 name: MINT_HUMAN-Phosphoserine2120 def: "Protein MINT_HUMAN with the residue 2120 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012935 name: MINT_HUMAN-Phosphoserine2126 def: "Protein MINT_HUMAN with the residue 2126 substituted with Phosphoserine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012936 name: MINT_HUMAN-Phosphothreonine2393 def: "Protein MINT_HUMAN with the residue 2393 substituted with Phosphothreonine" [UniProtKB:Q96T58] xref: UniProtKB:Q96T58 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006042 ! MINT_HUMAN [Term] id: CCO:B0012937 name: MK01_HUMAN-N-acetylalanine2 def: "Protein MK01_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P28482] xref: UniProtKB:P28482 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001565 ! MK01_HUMAN [Term] id: CCO:B0012938 name: MK01_HUMAN-Phosphothreonine185 def: "Protein MK01_HUMAN with the residue 185 substituted with Phosphothreonine" [UniProtKB:P28482] xref: UniProtKB:P28482 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001565 ! MK01_HUMAN [Term] id: CCO:B0012939 name: MK01_HUMAN-Phosphotyrosine187 def: "Protein MK01_HUMAN with the residue 187 substituted with Phosphotyrosine" [UniProtKB:P28482] xref: UniProtKB:P28482 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001073 ! MAP kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0001565 ! MK01_HUMAN [Term] id: CCO:B0012940 name: MK01_HUMAN-Phosphothreonine190 def: "Protein MK01_HUMAN with the residue 190 substituted with Phosphothreonine" [UniProtKB:P28482] comment: By similarity xref: UniProtKB:P28482 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001565 ! MK01_HUMAN [Term] id: CCO:B0012941 name: MK03_HUMAN-N-acetylalanine2 def: "Protein MK03_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P27361] xref: UniProtKB:P27361 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001073 ! MAP kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000200 ! cellular_component relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0001560 ! MK03_HUMAN [Term] id: CCO:B0012942 name: MK03_HUMAN-Phosphothreonine202 def: "Protein MK03_HUMAN with the residue 202 substituted with Phosphothreonine" [UniProtKB:P27361] xref: UniProtKB:P27361 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001560 ! MK03_HUMAN [Term] id: CCO:B0012943 name: MK03_HUMAN-Phosphotyrosine204 def: "Protein MK03_HUMAN with the residue 204 substituted with Phosphotyrosine" [UniProtKB:P27361] xref: UniProtKB:P27361 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001560 ! MK03_HUMAN [Term] id: CCO:B0012944 name: MK06_HUMAN-Phosphothreonine626 def: "Protein MK06_HUMAN with the residue 626 substituted with Phosphothreonine" [UniProtKB:Q16659] comment: By similarity xref: UniProtKB:Q16659 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001822 ! MK06_HUMAN [Term] id: CCO:B0012945 name: MK06_HUMAN-Phosphotyrosine628 def: "Protein MK06_HUMAN with the residue 628 substituted with Phosphotyrosine" [UniProtKB:Q16659] comment: By similarity xref: UniProtKB:Q16659 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001822 ! MK06_HUMAN [Term] id: CCO:B0012954 name: MK11_HUMAN-Phosphothreonine180 def: "Protein MK11_HUMAN with the residue 180 substituted with Phosphothreonine" [UniProtKB:Q15759] comment: Probable xref: UniProtKB:Q15759 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005892 ! MK11_HUMAN [Term] id: CCO:B0012955 name: MK11_HUMAN-Phosphotyrosine182 def: "Protein MK11_HUMAN with the residue 182 substituted with Phosphotyrosine" [UniProtKB:Q15759] comment: Probable xref: UniProtKB:Q15759 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005892 ! MK11_HUMAN [Term] id: CCO:B0012956 name: MK12_HUMAN-Phosphotyrosine27 def: "Protein MK12_HUMAN with the residue 27 substituted with Phosphotyrosine" [UniProtKB:P53778] xref: UniProtKB:P53778 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001665 ! MK12_HUMAN [Term] id: CCO:B0012957 name: MK12_HUMAN-Phosphothreonine183 def: "Protein MK12_HUMAN with the residue 183 substituted with Phosphothreonine" [UniProtKB:P53778] comment: By similarity xref: UniProtKB:P53778 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001665 ! MK12_HUMAN [Term] id: CCO:B0012958 name: MK12_HUMAN-Phosphotyrosine185 def: "Protein MK12_HUMAN with the residue 185 substituted with Phosphotyrosine" [UniProtKB:P53778] xref: UniProtKB:P53778 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001665 ! MK12_HUMAN [Term] id: CCO:B0012959 name: MK13_HUMAN-Phosphothreonine180 def: "Protein MK13_HUMAN with the residue 180 substituted with Phosphothreonine" [UniProtKB:O15264] xref: UniProtKB:O15264 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001369 ! MK13_HUMAN [Term] id: CCO:B0012960 name: MK13_HUMAN-Phosphotyrosine182 def: "Protein MK13_HUMAN with the residue 182 substituted with Phosphotyrosine" [UniProtKB:O15264] xref: UniProtKB:O15264 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001369 ! MK13_HUMAN [Term] id: CCO:B0012961 name: MLRM_HUMAN-N-acetylserine2 def: "Protein MLRM_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P19105] comment: By similarity xref: UniProtKB:P19105 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005759 ! MLRM_HUMAN [Term] id: CCO:B0012962 name: MLRM_HUMAN-Phosphothreonine18 def: "Protein MLRM_HUMAN with the residue 18 substituted with Phosphothreonine" [UniProtKB:P19105] comment: by MLCK; By similarity xref: UniProtKB:P19105 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005759 ! MLRM_HUMAN [Term] id: CCO:B0012963 name: MLRM_HUMAN-Phosphoserine19 def: "Protein MLRM_HUMAN with the residue 19 substituted with Phosphoserine" [UniProtKB:P19105] xref: UniProtKB:P19105 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005759 ! MLRM_HUMAN [Term] id: CCO:B0012964 name: MLTK_HUMAN-Phosphothreonine161 def: "Protein MLTK_HUMAN with the residue 161 substituted with Phosphothreonine" [UniProtKB:Q9NYL2] comment: by autocatalysis; xref: UniProtKB:Q9NYL2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002178 ! MLTK_HUMAN [Term] id: CCO:B0012965 name: MLTK_HUMAN-Phosphoserine165 def: "Protein MLTK_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:Q9NYL2] comment: by autocatalysis; xref: UniProtKB:Q9NYL2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002178 ! MLTK_HUMAN [Term] id: CCO:B0012966 name: MLTK_HUMAN-Phosphoserine635 def: "Protein MLTK_HUMAN with the residue 635 substituted with Phosphoserine" [UniProtKB:Q9NYL2] comment: By similarity xref: UniProtKB:Q9NYL2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002178 ! MLTK_HUMAN [Term] id: CCO:B0012967 name: MLTK_HUMAN-Phosphoserine637 def: "Protein MLTK_HUMAN with the residue 637 substituted with Phosphoserine" [UniProtKB:Q9NYL2] xref: UniProtKB:Q9NYL2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002178 ! MLTK_HUMAN [Term] id: CCO:B0012968 name: MLTK_HUMAN-Phosphothreonine639 def: "Protein MLTK_HUMAN with the residue 639 substituted with Phosphothreonine" [UniProtKB:Q9NYL2] comment: By similarity xref: UniProtKB:Q9NYL2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002178 ! MLTK_HUMAN [Term] id: CCO:B0012969 name: MON1A_HUMAN-Phosphoserine56 def: "Protein MON1A_HUMAN with the residue 56 substituted with Phosphoserine" [UniProtKB:Q86VX9] comment: By similarity xref: UniProtKB:Q86VX9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005970 ! MON1A_HUMAN [Term] id: CCO:B0012970 name: MON1A_HUMAN-Phosphotyrosine57 def: "Protein MON1A_HUMAN with the residue 57 substituted with Phosphotyrosine" [UniProtKB:Q86VX9] comment: By similarity xref: UniProtKB:Q86VX9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005970 ! MON1A_HUMAN [Term] id: CCO:B0012971 name: MON1A_HUMAN-Phosphoserine69 def: "Protein MON1A_HUMAN with the residue 69 substituted with Phosphoserine" [UniProtKB:Q86VX9] comment: By similarity xref: UniProtKB:Q86VX9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005970 ! MON1A_HUMAN [Term] id: CCO:B0012972 name: MON1A_HUMAN-Phosphoserine72 def: "Protein MON1A_HUMAN with the residue 72 substituted with Phosphoserine" [UniProtKB:Q86VX9] comment: By similarity xref: UniProtKB:Q86VX9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005970 ! MON1A_HUMAN [Term] id: CCO:B0012973 name: MORN_HUMAN-Pyrrolidone carboxylic acid1 def: "Protein MORN_HUMAN with the residue 1 substituted with Pyrrolidone carboxylic acid" [UniProtKB:P69208] xref: UniProtKB:P69208 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001698 ! MORN_HUMAN [Term] id: CCO:B0012976 name: MP2K6_HUMAN-O-acetylserine207 def: "Protein MP2K6_HUMAN with the residue 207 substituted with O-acetylserine" [UniProtKB:P52564] comment: by Yersinia yopJ; alternate; xref: UniProtKB:P52564 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001658 ! MP2K6_HUMAN [Term] id: CCO:B0012977 name: MP2K6_HUMAN-Phosphoserine207 def: "Protein MP2K6_HUMAN with the residue 207 substituted with Phosphoserine" [UniProtKB:P52564] comment: alternate; xref: UniProtKB:P52564 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001074 ! MAP kinase kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0008374 ! protein tyrosine kinase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001658 ! MP2K6_HUMAN [Term] id: CCO:B0012978 name: MP2K6_HUMAN-O-acetylthreonine211 def: "Protein MP2K6_HUMAN with the residue 211 substituted with O-acetylthreonine" [UniProtKB:P52564] comment: by Yersinia yopJ; alternate; xref: UniProtKB:P52564 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001658 ! MP2K6_HUMAN [Term] id: CCO:B0012979 name: MP2K6_HUMAN-Phosphothreonine211 def: "Protein MP2K6_HUMAN with the residue 211 substituted with Phosphothreonine" [UniProtKB:P52564] comment: alternate; xref: UniProtKB:P52564 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001658 ! MP2K6_HUMAN [Term] id: CCO:B0012980 name: MPCP_HUMAN-N6-acetyllysine99 def: "Protein MPCP_HUMAN with the residue 99 substituted with N6-acetyllysine" [UniProtKB:Q00325] comment: By similarity xref: UniProtKB:Q00325 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005847 ! MPCP_HUMAN [Term] id: CCO:B0012981 name: MPCP_HUMAN-N6-acetyllysine209 def: "Protein MPCP_HUMAN with the residue 209 substituted with N6-acetyllysine" [UniProtKB:Q00325] comment: By similarity xref: UniProtKB:Q00325 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005847 ! MPCP_HUMAN [Term] id: CCO:B0012982 name: MPH6_HUMAN-Phosphothreonine147 def: "Protein MPH6_HUMAN with the residue 147 substituted with Phosphothreonine" [UniProtKB:Q99547] xref: UniProtKB:Q99547 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002071 ! MPH6_HUMAN [Term] id: CCO:B0012983 name: MPIP1_HUMAN-Phosphoserine76 def: "Protein MPIP1_HUMAN with the residue 76 substituted with Phosphoserine" [UniProtKB:P30304] comment: by CHK1; xref: UniProtKB:P30304 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001576 ! MPIP1_HUMAN [Term] id: CCO:B0012984 name: MPIP1_HUMAN-Phosphoserine124 def: "Protein MPIP1_HUMAN with the residue 124 substituted with Phosphoserine" [UniProtKB:P30304] comment: by CHK1 and CHK2; xref: UniProtKB:P30304 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001576 ! MPIP1_HUMAN [Term] id: CCO:B0012985 name: MPIP1_HUMAN-Phosphoserine178 def: "Protein MPIP1_HUMAN with the residue 178 substituted with Phosphoserine" [UniProtKB:P30304] comment: by CHK1; xref: UniProtKB:P30304 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001576 ! MPIP1_HUMAN [Term] id: CCO:B0012986 name: MPIP1_HUMAN-Phosphoserine279 def: "Protein MPIP1_HUMAN with the residue 279 substituted with Phosphoserine" [UniProtKB:P30304] comment: by CHK1 and CHK2; xref: UniProtKB:P30304 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001576 ! MPIP1_HUMAN [Term] id: CCO:B0012987 name: MPIP1_HUMAN-Phosphoserine293 def: "Protein MPIP1_HUMAN with the residue 293 substituted with Phosphoserine" [UniProtKB:P30304] comment: by CHK1 and CHK2; xref: UniProtKB:P30304 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001576 ! MPIP1_HUMAN [Term] id: CCO:B0012988 name: MPIP1_HUMAN-Phosphothreonine507 def: "Protein MPIP1_HUMAN with the residue 507 substituted with Phosphothreonine" [UniProtKB:P30304] comment: by CHK1; xref: UniProtKB:P30304 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001576 ! MPIP1_HUMAN [Term] id: CCO:B0012989 name: MPIP3_HUMAN-Phosphoserine168 def: "Protein MPIP3_HUMAN with the residue 168 substituted with Phosphoserine" [UniProtKB:P30307] xref: UniProtKB:P30307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001578 ! MPIP3_HUMAN [Term] id: CCO:B0012990 name: MPIP3_HUMAN-Phosphoserine216 def: "Protein MPIP3_HUMAN with the residue 216 substituted with Phosphoserine" [UniProtKB:P30307] comment: by CHK1, CHK2 and BRSK1; xref: UniProtKB:P30307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001578 ! MPIP3_HUMAN [Term] id: CCO:B0012991 name: MPP8_HUMAN-Phosphoserine51 def: "Protein MPP8_HUMAN with the residue 51 substituted with Phosphoserine" [UniProtKB:Q99549] xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0012992 name: MPP8_HUMAN-Phosphoserine136 def: "Protein MPP8_HUMAN with the residue 136 substituted with Phosphoserine" [UniProtKB:Q99549] xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0012993 name: MPP8_HUMAN-Phosphoserine138 def: "Protein MPP8_HUMAN with the residue 138 substituted with Phosphoserine" [UniProtKB:Q99549] xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0012994 name: MPP8_HUMAN-Phosphoserine164 def: "Protein MPP8_HUMAN with the residue 164 substituted with Phosphoserine" [UniProtKB:Q99549] xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0012995 name: MPP8_HUMAN-Phosphoserine272 def: "Protein MPP8_HUMAN with the residue 272 substituted with Phosphoserine" [UniProtKB:Q99549] comment: Potential xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0012996 name: MPP8_HUMAN-Phosphoserine319 def: "Protein MPP8_HUMAN with the residue 319 substituted with Phosphoserine" [UniProtKB:Q99549] xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0012997 name: MPP8_HUMAN-Phosphothreonine334 def: "Protein MPP8_HUMAN with the residue 334 substituted with Phosphothreonine" [UniProtKB:Q99549] comment: Potential xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0012998 name: MPP8_HUMAN-Phosphothreonine385 def: "Protein MPP8_HUMAN with the residue 385 substituted with Phosphothreonine" [UniProtKB:Q99549] comment: Potential xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0012999 name: MPP8_HUMAN-Phosphoserine392 def: "Protein MPP8_HUMAN with the residue 392 substituted with Phosphoserine" [UniProtKB:Q99549] xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0013000 name: MPP8_HUMAN-Phosphothreonine454 def: "Protein MPP8_HUMAN with the residue 454 substituted with Phosphothreonine" [UniProtKB:Q99549] comment: Potential xref: UniProtKB:Q99549 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002072 ! MPP8_HUMAN [Term] id: CCO:B0013001 name: MPPH1_HUMAN-Phosphoserine303 def: "Protein MPPH1_HUMAN with the residue 303 substituted with Phosphoserine" [UniProtKB:Q96Q89] comment: By similarity xref: UniProtKB:Q96Q89 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002056 ! MPPH1_HUMAN [Term] id: CCO:B0013002 name: MPPH1_HUMAN-Phosphoserine310 def: "Protein MPPH1_HUMAN with the residue 310 substituted with Phosphoserine" [UniProtKB:Q96Q89] xref: UniProtKB:Q96Q89 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002056 ! MPPH1_HUMAN [Term] id: CCO:B0013003 name: MPPH1_HUMAN-Phosphoserine321 def: "Protein MPPH1_HUMAN with the residue 321 substituted with Phosphoserine" [UniProtKB:Q96Q89] xref: UniProtKB:Q96Q89 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002056 ! MPPH1_HUMAN [Term] id: CCO:B0013004 name: MPPH1_HUMAN-Phosphoserine323 def: "Protein MPPH1_HUMAN with the residue 323 substituted with Phosphoserine" [UniProtKB:Q96Q89] xref: UniProtKB:Q96Q89 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002056 ! MPPH1_HUMAN [Term] id: CCO:B0013005 name: MPPH1_HUMAN-Phosphoserine488 def: "Protein MPPH1_HUMAN with the residue 488 substituted with Phosphoserine" [UniProtKB:Q96Q89] xref: UniProtKB:Q96Q89 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002056 ! MPPH1_HUMAN [Term] id: CCO:B0013006 name: MPPH1_HUMAN-Phosphoserine999 def: "Protein MPPH1_HUMAN with the residue 999 substituted with Phosphoserine" [UniProtKB:Q96Q89] xref: UniProtKB:Q96Q89 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002056 ! MPPH1_HUMAN [Term] id: CCO:B0013007 name: MPPH1_HUMAN-Phosphoserine1071 def: "Protein MPPH1_HUMAN with the residue 1071 substituted with Phosphoserine" [UniProtKB:Q96Q89] xref: UniProtKB:Q96Q89 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002056 ! MPPH1_HUMAN [Term] id: CCO:B0013008 name: MPPH1_HUMAN-Phosphoserine1072 def: "Protein MPPH1_HUMAN with the residue 1072 substituted with Phosphoserine" [UniProtKB:Q96Q89] xref: UniProtKB:Q96Q89 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002056 ! MPPH1_HUMAN [Term] id: CCO:B0013009 name: MPPH1_HUMAN-Phosphothreonine1644 def: "Protein MPPH1_HUMAN with the residue 1644 substituted with Phosphothreonine" [UniProtKB:Q96Q89] comment: by CDC2; xref: UniProtKB:Q96Q89 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002056 ! MPPH1_HUMAN [Term] id: CCO:B0013010 name: MRE11_HUMAN-Phosphothreonine74 def: "Protein MRE11_HUMAN with the residue 74 substituted with Phosphothreonine" [UniProtKB:P49959] xref: UniProtKB:P49959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001641 ! MRE11_HUMAN [Term] id: CCO:B0013011 name: MRE11_HUMAN-Phosphoserine678 def: "Protein MRE11_HUMAN with the residue 678 substituted with Phosphoserine" [UniProtKB:P49959] xref: UniProtKB:P49959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001641 ! MRE11_HUMAN [Term] id: CCO:B0013012 name: MRE11_HUMAN-Phosphoserine688 def: "Protein MRE11_HUMAN with the residue 688 substituted with Phosphoserine" [UniProtKB:P49959] xref: UniProtKB:P49959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000005 ! single-stranded DNA specific endodeoxyribonuclease activity relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000282 ! double-stranded DNA binding relationship: has_function CCO:F0000915 ! nuclease activity relationship: has_function CCO:F0000916 ! endonuclease activity relationship: has_function CCO:F0000917 ! endodeoxyribonuclease activity relationship: has_function CCO:F0000923 ! exonuclease activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0001875 ! 3'-5' exonuclease activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: transformation_of CCO:B0001641 ! MRE11_HUMAN [Term] id: CCO:B0013013 name: MRE11_HUMAN-Phosphoserine689 def: "Protein MRE11_HUMAN with the residue 689 substituted with Phosphoserine" [UniProtKB:P49959] xref: UniProtKB:P49959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001641 ! MRE11_HUMAN [Term] id: CCO:B0013014 name: MSH2_HUMAN-Phosphoserine860 def: "Protein MSH2_HUMAN with the residue 860 substituted with Phosphoserine" [UniProtKB:P43246] xref: UniProtKB:P43246 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0000082 ! four-way junction DNA binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000282 ! double-stranded DNA binding relationship: has_function CCO:F0000288 ! single-stranded DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0003445 ! ATPase activity relationship: has_function CCO:F0004616 ! mismatched DNA binding relationship: has_function CCO:F0004950 ! mispaired DNA binding relationship: has_function CCO:F0004953 ! guanine/thymine mispair binding relationship: has_function CCO:F0004955 ! dinucleotide insertion or deletion binding relationship: has_function CCO:F0004958 ! single guanine insertion binding relationship: has_function CCO:F0004959 ! single thymine insertion binding relationship: has_function CCO:F0004962 ! dinucleotide repeat insertion binding relationship: has_function CCO:F0004975 ! oxidized purine DNA binding relationship: has_function CCO:F0004985 ! MutLalpha complex binding relationship: has_function CCO:F0005713 ! identical protein binding relationship: has_function CCO:F0005714 ! protein homodimerization activity relationship: has_function CCO:F0005867 ! ADP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0001438 ! MutSalpha complex relationship: located_in CCO:C0001439 ! MutSbeta complex relationship: transformation_of CCO:B0001620 ! MSH2_HUMAN [Term] id: CCO:B0013015 name: MSH3_HUMAN-Phosphoserine201 def: "Protein MSH3_HUMAN with the residue 201 substituted with Phosphoserine" [UniProtKB:P20585] xref: UniProtKB:P20585 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005720 ! MSH3_HUMAN [Term] id: CCO:B0013016 name: MSH6_HUMAN-Phosphoserine14 def: "Protein MSH6_HUMAN with the residue 14 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013017 name: MSH6_HUMAN-Phosphoserine41 def: "Protein MSH6_HUMAN with the residue 41 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013018 name: MSH6_HUMAN-Phosphoserine43 def: "Protein MSH6_HUMAN with the residue 43 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013019 name: MSH6_HUMAN-Phosphoserine137 def: "Protein MSH6_HUMAN with the residue 137 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013020 name: MSH6_HUMAN-Phosphothreonine139 def: "Protein MSH6_HUMAN with the residue 139 substituted with Phosphothreonine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013021 name: MSH6_HUMAN-Phosphoserine219 def: "Protein MSH6_HUMAN with the residue 219 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013022 name: MSH6_HUMAN-Phosphoserine227 def: "Protein MSH6_HUMAN with the residue 227 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013023 name: MSH6_HUMAN-Phosphoserine252 def: "Protein MSH6_HUMAN with the residue 252 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013024 name: MSH6_HUMAN-Phosphoserine254 def: "Protein MSH6_HUMAN with the residue 254 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013025 name: MSH6_HUMAN-Phosphoserine256 def: "Protein MSH6_HUMAN with the residue 256 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013026 name: MSH6_HUMAN-Phosphoserine261 def: "Protein MSH6_HUMAN with the residue 261 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013027 name: MSH6_HUMAN-Phosphoserine348 def: "Protein MSH6_HUMAN with the residue 348 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013028 name: MSH6_HUMAN-Phosphoserine830 def: "Protein MSH6_HUMAN with the residue 830 substituted with Phosphoserine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013029 name: MSH6_HUMAN-Phosphothreonine924 def: "Protein MSH6_HUMAN with the residue 924 substituted with Phosphothreonine" [UniProtKB:P52701] xref: UniProtKB:P52701 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:B0013030 name: MTFR1_HUMAN-Phosphotyrosine30 def: "Protein MTFR1_HUMAN with the residue 30 substituted with Phosphotyrosine" [UniProtKB:Q15390] xref: UniProtKB:Q15390 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006321 ! MTFR1_HUMAN [Term] id: CCO:B0013031 name: MTFR1_HUMAN-Phosphoserine32 def: "Protein MTFR1_HUMAN with the residue 32 substituted with Phosphoserine" [UniProtKB:Q15390] xref: UniProtKB:Q15390 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006321 ! MTFR1_HUMAN [Term] id: CCO:B0013032 name: MTFR1_HUMAN-Phosphoserine33 def: "Protein MTFR1_HUMAN with the residue 33 substituted with Phosphoserine" [UniProtKB:Q15390] xref: UniProtKB:Q15390 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006321 ! MTFR1_HUMAN [Term] id: CCO:B0013033 name: MTFR1_HUMAN-Phosphoserine119 def: "Protein MTFR1_HUMAN with the residue 119 substituted with Phosphoserine" [UniProtKB:Q15390] comment: By similarity xref: UniProtKB:Q15390 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006321 ! MTFR1_HUMAN [Term] id: CCO:B0013034 name: MTFR1_HUMAN-Phosphoserine290 def: "Protein MTFR1_HUMAN with the residue 290 substituted with Phosphoserine" [UniProtKB:Q15390] xref: UniProtKB:Q15390 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006321 ! MTFR1_HUMAN [Term] id: CCO:B0013035 name: MTMR6_HUMAN-Phosphoserine561 def: "Protein MTMR6_HUMAN with the residue 561 substituted with Phosphoserine" [UniProtKB:Q9Y217] xref: UniProtKB:Q9Y217 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006052 ! MTMR6_HUMAN [Term] id: CCO:B0013036 name: MTSS1_HUMAN-Phosphothreonine258 def: "Protein MTSS1_HUMAN with the residue 258 substituted with Phosphothreonine" [UniProtKB:O43312] xref: UniProtKB:O43312 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001390 ! MTSS1_HUMAN [Term] id: CCO:B0013037 name: MTSS1_HUMAN-Phosphoserine272 def: "Protein MTSS1_HUMAN with the residue 272 substituted with Phosphoserine" [UniProtKB:O43312] comment: By similarity xref: UniProtKB:O43312 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001390 ! MTSS1_HUMAN [Term] id: CCO:B0013038 name: MTSS1_HUMAN-Phosphoserine315 def: "Protein MTSS1_HUMAN with the residue 315 substituted with Phosphoserine" [UniProtKB:O43312] comment: By similarity xref: UniProtKB:O43312 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001390 ! MTSS1_HUMAN [Term] id: CCO:B0013039 name: MTSS1_HUMAN-Phosphoserine316 def: "Protein MTSS1_HUMAN with the residue 316 substituted with Phosphoserine" [UniProtKB:O43312] comment: By similarity xref: UniProtKB:O43312 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001390 ! MTSS1_HUMAN [Term] id: CCO:B0013040 name: MTSS1_HUMAN-Phosphoserine569 def: "Protein MTSS1_HUMAN with the residue 569 substituted with Phosphoserine" [UniProtKB:O43312] comment: By similarity xref: UniProtKB:O43312 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001390 ! MTSS1_HUMAN [Term] id: CCO:B0013041 name: MTUS1_HUMAN-Phosphoserine381 def: "Protein MTUS1_HUMAN with the residue 381 substituted with Phosphoserine" [UniProtKB:Q9ULD2] comment: By similarity xref: UniProtKB:Q9ULD2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002224 ! MTUS1_HUMAN [Term] id: CCO:B0013042 name: MTUS1_HUMAN-Phosphoserine443 def: "Protein MTUS1_HUMAN with the residue 443 substituted with Phosphoserine" [UniProtKB:Q9ULD2] xref: UniProtKB:Q9ULD2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002224 ! MTUS1_HUMAN [Term] id: CCO:B0013043 name: MTUS1_HUMAN-Phosphoserine620 def: "Protein MTUS1_HUMAN with the residue 620 substituted with Phosphoserine" [UniProtKB:Q9ULD2] comment: By similarity xref: UniProtKB:Q9ULD2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002224 ! MTUS1_HUMAN [Term] id: CCO:B0013044 name: MTUS1_HUMAN-Phosphoserine1245 def: "Protein MTUS1_HUMAN with the residue 1245 substituted with Phosphoserine" [UniProtKB:Q9ULD2] comment: By similarity xref: UniProtKB:Q9ULD2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002224 ! MTUS1_HUMAN [Term] id: CCO:B0013045 name: MTUS1_HUMAN-Phosphoserine1255 def: "Protein MTUS1_HUMAN with the residue 1255 substituted with Phosphoserine" [UniProtKB:Q9ULD2] comment: By similarity xref: UniProtKB:Q9ULD2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002224 ! MTUS1_HUMAN [Term] id: CCO:B0013046 name: MTUS1_HUMAN-Phosphoserine1264 def: "Protein MTUS1_HUMAN with the residue 1264 substituted with Phosphoserine" [UniProtKB:Q9ULD2] xref: UniProtKB:Q9ULD2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000325 ! mitochondrion relationship: located_in CCO:C0000375 ! Golgi apparatus relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: transformation_of CCO:B0002224 ! MTUS1_HUMAN [Term] id: CCO:B0013047 name: MTUS1_HUMAN-Phosphoserine1266 def: "Protein MTUS1_HUMAN with the residue 1266 substituted with Phosphoserine" [UniProtKB:Q9ULD2] comment: By similarity xref: UniProtKB:Q9ULD2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002224 ! MTUS1_HUMAN [Term] id: CCO:B0013048 name: MTUS1_HUMAN-Phosphoserine1268 def: "Protein MTUS1_HUMAN with the residue 1268 substituted with Phosphoserine" [UniProtKB:Q9ULD2] xref: UniProtKB:Q9ULD2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002224 ! MTUS1_HUMAN [Term] id: CCO:B0013057 name: MYC_HUMAN-Phosphothreonine8 def: "Protein MYC_HUMAN with the residue 8 substituted with Phosphothreonine" [UniProtKB:P01106] comment: by RAF; in vitro; xref: UniProtKB:P01106 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001465 ! MYC_HUMAN [Term] id: CCO:B0013058 name: MYC_HUMAN-Phosphothreonine58 def: "Protein MYC_HUMAN with the residue 58 substituted with Phosphothreonine" [UniProtKB:P01106] comment: alternate; xref: UniProtKB:P01106 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001465 ! MYC_HUMAN [Term] id: CCO:B0013059 name: MYC_HUMAN-Phosphoserine62 def: "Protein MYC_HUMAN with the residue 62 substituted with Phosphoserine" [UniProtKB:P01106] xref: UniProtKB:P01106 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001465 ! MYC_HUMAN [Term] id: CCO:B0013060 name: MYC_HUMAN-N6-acetyllysine143 def: "Protein MYC_HUMAN with the residue 143 substituted with N6-acetyllysine" [UniProtKB:P01106] comment: by PCAF; xref: UniProtKB:P01106 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001465 ! MYC_HUMAN [Term] id: CCO:B0013061 name: MYC_HUMAN-N6-acetyllysine157 def: "Protein MYC_HUMAN with the residue 157 substituted with N6-acetyllysine" [UniProtKB:P01106] comment: by PCAF; xref: UniProtKB:P01106 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001465 ! MYC_HUMAN [Term] id: CCO:B0013062 name: MYC_HUMAN-N6-acetyllysine275 def: "Protein MYC_HUMAN with the residue 275 substituted with N6-acetyllysine" [UniProtKB:P01106] comment: by PCAF; xref: UniProtKB:P01106 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001465 ! MYC_HUMAN [Term] id: CCO:B0013063 name: MYC_HUMAN-N6-acetyllysine317 def: "Protein MYC_HUMAN with the residue 317 substituted with N6-acetyllysine" [UniProtKB:P01106] comment: by PCAF; xref: UniProtKB:P01106 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001465 ! MYC_HUMAN [Term] id: CCO:B0013064 name: MYC_HUMAN-N6-acetyllysine323 def: "Protein MYC_HUMAN with the residue 323 substituted with N6-acetyllysine" [UniProtKB:P01106] comment: by PCAF; xref: UniProtKB:P01106 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001465 ! MYC_HUMAN [Term] id: CCO:B0013065 name: MYC_HUMAN-N6-acetyllysine371 def: "Protein MYC_HUMAN with the residue 371 substituted with N6-acetyllysine" [UniProtKB:P01106] comment: by PCAF; xref: UniProtKB:P01106 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001465 ! MYC_HUMAN [Term] id: CCO:B0013066 name: MYH14_HUMAN-N-acetylalanine2 def: "Protein MYH14_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q7Z406] xref: UniProtKB:Q7Z406 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005971 ! MYH14_HUMAN [Term] id: CCO:B0013067 name: MYL6_HUMAN-N-acetylcysteine2 def: "Protein MYL6_HUMAN with the residue 2 substituted with N-acetylcysteine" [UniProtKB:P60660] xref: UniProtKB:P60660 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005743 ! MYL6_HUMAN [Term] id: CCO:B0013070 name: MYP0_HUMAN-Phosphoserine226 def: "Protein MYP0_HUMAN with the residue 226 substituted with Phosphoserine" [UniProtKB:P25189] comment: By similarity xref: UniProtKB:P25189 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006337 ! MYP0_HUMAN [Term] id: CCO:B0013071 name: MYP0_HUMAN-Phosphoserine228 def: "Protein MYP0_HUMAN with the residue 228 substituted with Phosphoserine" [UniProtKB:P25189] comment: By similarity xref: UniProtKB:P25189 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006337 ! MYP0_HUMAN [Term] id: CCO:B0013072 name: MYP0_HUMAN-Phosphoserine233 def: "Protein MYP0_HUMAN with the residue 233 substituted with Phosphoserine" [UniProtKB:P25189] comment: By similarity xref: UniProtKB:P25189 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006337 ! MYP0_HUMAN [Term] id: CCO:B0013073 name: MYP0_HUMAN-Phosphoserine243 def: "Protein MYP0_HUMAN with the residue 243 substituted with Phosphoserine" [UniProtKB:P25189] comment: By similarity xref: UniProtKB:P25189 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006337 ! MYP0_HUMAN [Term] id: CCO:B0013074 name: MYST2_HUMAN-Phosphoserine50 def: "Protein MYST2_HUMAN with the residue 50 substituted with Phosphoserine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013075 name: MYST2_HUMAN-Phosphoserine52 def: "Protein MYST2_HUMAN with the residue 52 substituted with Phosphoserine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013076 name: MYST2_HUMAN-Phosphoserine53 def: "Protein MYST2_HUMAN with the residue 53 substituted with Phosphoserine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013077 name: MYST2_HUMAN-Phosphoserine56 def: "Protein MYST2_HUMAN with the residue 56 substituted with Phosphoserine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013078 name: MYST2_HUMAN-Phosphoserine57 def: "Protein MYST2_HUMAN with the residue 57 substituted with Phosphoserine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013079 name: MYST2_HUMAN-Phosphothreonine88 def: "Protein MYST2_HUMAN with the residue 88 substituted with Phosphothreonine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013080 name: MYST2_HUMAN-Phosphoserine99 def: "Protein MYST2_HUMAN with the residue 99 substituted with Phosphoserine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013081 name: MYST2_HUMAN-Phosphoserine100 def: "Protein MYST2_HUMAN with the residue 100 substituted with Phosphoserine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013082 name: MYST2_HUMAN-Phosphoserine102 def: "Protein MYST2_HUMAN with the residue 102 substituted with Phosphoserine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013083 name: MYST2_HUMAN-Phosphoserine124 def: "Protein MYST2_HUMAN with the residue 124 substituted with Phosphoserine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013084 name: MYST2_HUMAN-Phosphothreonine128 def: "Protein MYST2_HUMAN with the residue 128 substituted with Phosphothreonine" [UniProtKB:O95251] xref: UniProtKB:O95251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:B0013085 name: NACA_HUMAN-Phosphoserine43 def: "Protein NACA_HUMAN with the residue 43 substituted with Phosphoserine" [UniProtKB:Q13765] comment: by ILK1; By similarity xref: UniProtKB:Q13765 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006096 ! NACA_HUMAN [Term] id: CCO:B0013086 name: NACA_HUMAN-Phosphothreonine92 def: "Protein NACA_HUMAN with the residue 92 substituted with Phosphothreonine" [UniProtKB:Q13765] xref: UniProtKB:Q13765 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006096 ! NACA_HUMAN [Term] id: CCO:B0013087 name: NACA_HUMAN-Phosphothreonine159 def: "Protein NACA_HUMAN with the residue 159 substituted with Phosphothreonine" [UniProtKB:Q13765] comment: by GSK3-beta; By similarity xref: UniProtKB:Q13765 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006096 ! NACA_HUMAN [Term] id: CCO:B0013088 name: NACA_HUMAN-Phosphothreonine161 def: "Protein NACA_HUMAN with the residue 161 substituted with Phosphothreonine" [UniProtKB:Q13765] comment: By similarity xref: UniProtKB:Q13765 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006096 ! NACA_HUMAN [Term] id: CCO:B0013089 name: NACA_HUMAN-Phosphoserine166 def: "Protein NACA_HUMAN with the residue 166 substituted with Phosphoserine" [UniProtKB:Q13765] xref: UniProtKB:Q13765 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006096 ! NACA_HUMAN [Term] id: CCO:B0013090 name: NACA_HUMAN-Phosphoserine186 def: "Protein NACA_HUMAN with the residue 186 substituted with Phosphoserine" [UniProtKB:Q13765] xref: UniProtKB:Q13765 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006096 ! NACA_HUMAN [Term] id: CCO:B0013091 name: NASP_HUMAN-Phosphoserine189 def: "Protein NASP_HUMAN with the residue 189 substituted with Phosphoserine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013092 name: NASP_HUMAN-Phosphothreonine228 def: "Protein NASP_HUMAN with the residue 228 substituted with Phosphothreonine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013093 name: NASP_HUMAN-Phosphoserine244 def: "Protein NASP_HUMAN with the residue 244 substituted with Phosphoserine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013094 name: NASP_HUMAN-Phosphothreonine390 def: "Protein NASP_HUMAN with the residue 390 substituted with Phosphothreonine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013095 name: NASP_HUMAN-Phosphoserine421 def: "Protein NASP_HUMAN with the residue 421 substituted with Phosphoserine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013096 name: NASP_HUMAN-Phosphoserine451 def: "Protein NASP_HUMAN with the residue 451 substituted with Phosphoserine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013097 name: NASP_HUMAN-Phosphothreonine464 def: "Protein NASP_HUMAN with the residue 464 substituted with Phosphothreonine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013098 name: NASP_HUMAN-Phosphothreonine477 def: "Protein NASP_HUMAN with the residue 477 substituted with Phosphothreonine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013099 name: NASP_HUMAN-Phosphoserine480 def: "Protein NASP_HUMAN with the residue 480 substituted with Phosphoserine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013100 name: NASP_HUMAN-Phosphoserine497 def: "Protein NASP_HUMAN with the residue 497 substituted with Phosphoserine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013101 name: NASP_HUMAN-Phosphoserine503 def: "Protein NASP_HUMAN with the residue 503 substituted with Phosphoserine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013102 name: NASP_HUMAN-Phosphoserine726 def: "Protein NASP_HUMAN with the residue 726 substituted with Phosphoserine" [UniProtKB:P49321] xref: UniProtKB:P49321 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001626 ! NASP_HUMAN [Term] id: CCO:B0013103 name: NBN_HUMAN-Phosphoserine278 def: "Protein NBN_HUMAN with the residue 278 substituted with Phosphoserine" [UniProtKB:O60934] comment: by ATM; xref: UniProtKB:O60934 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001421 ! NBN_HUMAN [Term] id: CCO:B0013104 name: NBN_HUMAN-Phosphoserine343 def: "Protein NBN_HUMAN with the residue 343 substituted with Phosphoserine" [UniProtKB:O60934] comment: by ATM; xref: UniProtKB:O60934 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001421 ! NBN_HUMAN [Term] id: CCO:B0013105 name: NBN_HUMAN-Phosphoserine397 def: "Protein NBN_HUMAN with the residue 397 substituted with Phosphoserine" [UniProtKB:O60934] xref: UniProtKB:O60934 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001421 ! NBN_HUMAN [Term] id: CCO:B0013106 name: NBN_HUMAN-Phosphoserine432 def: "Protein NBN_HUMAN with the residue 432 substituted with Phosphoserine" [UniProtKB:O60934] xref: UniProtKB:O60934 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001421 ! NBN_HUMAN [Term] id: CCO:B0013107 name: NBN_HUMAN-Phosphoserine615 def: "Protein NBN_HUMAN with the residue 615 substituted with Phosphoserine" [UniProtKB:O60934] xref: UniProtKB:O60934 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001421 ! NBN_HUMAN [Term] id: CCO:B0013108 name: NCOA6_HUMAN-Phosphoserine884 def: "Protein NCOA6_HUMAN with the residue 884 substituted with Phosphoserine" [UniProtKB:Q14686] comment: by MAPK; in vitro; xref: UniProtKB:Q14686 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005893 ! NCOA6_HUMAN [Term] id: CCO:B0013109 name: NCOA6_HUMAN-Phosphothreonine1321 def: "Protein NCOA6_HUMAN with the residue 1321 substituted with Phosphothreonine" [UniProtKB:Q14686] xref: UniProtKB:Q14686 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005893 ! NCOA6_HUMAN [Term] id: CCO:B0013110 name: NCOR2_HUMAN-Phosphoserine149 def: "Protein NCOR2_HUMAN with the residue 149 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013111 name: NCOR2_HUMAN-Phosphoserine152 def: "Protein NCOR2_HUMAN with the residue 152 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013112 name: NCOR2_HUMAN-Phosphoserine215 def: "Protein NCOR2_HUMAN with the residue 215 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013113 name: NCOR2_HUMAN-Phosphothreonine553 def: "Protein NCOR2_HUMAN with the residue 553 substituted with Phosphothreonine" [UniProtKB:Q9Y618] comment: By similarity xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013114 name: NCOR2_HUMAN-Phosphoserine554 def: "Protein NCOR2_HUMAN with the residue 554 substituted with Phosphoserine" [UniProtKB:Q9Y618] comment: By similarity xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013115 name: NCOR2_HUMAN-Phosphoserine939 def: "Protein NCOR2_HUMAN with the residue 939 substituted with Phosphoserine" [UniProtKB:Q9Y618] comment: By similarity xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013116 name: NCOR2_HUMAN-Phosphoserine1253 def: "Protein NCOR2_HUMAN with the residue 1253 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013117 name: NCOR2_HUMAN-Phosphothreonine1383 def: "Protein NCOR2_HUMAN with the residue 1383 substituted with Phosphothreonine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013118 name: NCOR2_HUMAN-Phosphoserine1576 def: "Protein NCOR2_HUMAN with the residue 1576 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013119 name: NCOR2_HUMAN-Phosphoserine1974 def: "Protein NCOR2_HUMAN with the residue 1974 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013120 name: NCOR2_HUMAN-Phosphoserine2008 def: "Protein NCOR2_HUMAN with the residue 2008 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013121 name: NCOR2_HUMAN-Phosphoserine2049 def: "Protein NCOR2_HUMAN with the residue 2049 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013122 name: NCOR2_HUMAN-Phosphoserine2057 def: "Protein NCOR2_HUMAN with the residue 2057 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013123 name: NCOR2_HUMAN-Phosphoserine2061 def: "Protein NCOR2_HUMAN with the residue 2061 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013124 name: NCOR2_HUMAN-Phosphoserine2197 def: "Protein NCOR2_HUMAN with the residue 2197 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013125 name: NCOR2_HUMAN-Phosphoserine2200 def: "Protein NCOR2_HUMAN with the residue 2200 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013126 name: NCOR2_HUMAN-Phosphoserine2261 def: "Protein NCOR2_HUMAN with the residue 2261 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013127 name: NCOR2_HUMAN-Phosphoserine2455 def: "Protein NCOR2_HUMAN with the residue 2455 substituted with Phosphoserine" [UniProtKB:Q9Y618] comment: By similarity xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013128 name: NCOR2_HUMAN-Phosphoserine2514 def: "Protein NCOR2_HUMAN with the residue 2514 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013129 name: NCOR2_HUMAN-Phosphoserine2516 def: "Protein NCOR2_HUMAN with the residue 2516 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0013130 name: NDE1_HUMAN-Phosphothreonine246 def: "Protein NDE1_HUMAN with the residue 246 substituted with Phosphothreonine" [UniProtKB:Q9NXR1] comment: By similarity xref: UniProtKB:Q9NXR1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002173 ! NDE1_HUMAN [Term] id: CCO:B0013131 name: NDE1_HUMAN-Phosphotyrosine279 def: "Protein NDE1_HUMAN with the residue 279 substituted with Phosphotyrosine" [UniProtKB:Q9NXR1] xref: UniProtKB:Q9NXR1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002173 ! NDE1_HUMAN [Term] id: CCO:B0013132 name: NDE1_HUMAN-Phosphoserine282 def: "Protein NDE1_HUMAN with the residue 282 substituted with Phosphoserine" [UniProtKB:Q9NXR1] xref: UniProtKB:Q9NXR1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002173 ! NDE1_HUMAN [Term] id: CCO:B0013133 name: NDE1_HUMAN-Phosphoserine306 def: "Protein NDE1_HUMAN with the residue 306 substituted with Phosphoserine" [UniProtKB:Q9NXR1] xref: UniProtKB:Q9NXR1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001679 ! microtubule binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000421 ! cytoskeleton relationship: located_in CCO:C0000434 ! microtubule relationship: located_in CCO:C0001322 ! spindle pole centrosome relationship: transformation_of CCO:B0002173 ! NDE1_HUMAN [Term] id: CCO:B0013134 name: NDE1_HUMAN-Phosphoserine307 def: "Protein NDE1_HUMAN with the residue 307 substituted with Phosphoserine" [UniProtKB:Q9NXR1] xref: UniProtKB:Q9NXR1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002173 ! NDE1_HUMAN [Term] id: CCO:B0013135 name: NDEL1_HUMAN-Phosphoserine215 def: "Protein NDEL1_HUMAN with the residue 215 substituted with Phosphoserine" [UniProtKB:Q9GZM8] comment: By similarity xref: UniProtKB:Q9GZM8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005926 ! NDEL1_HUMAN [Term] id: CCO:B0013136 name: NDEL1_HUMAN-Phosphothreonine219 def: "Protein NDEL1_HUMAN with the residue 219 substituted with Phosphothreonine" [UniProtKB:Q9GZM8] comment: by CDC2 and MAPK1; xref: UniProtKB:Q9GZM8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005926 ! NDEL1_HUMAN [Term] id: CCO:B0013137 name: NDEL1_HUMAN-Phosphoserine242 def: "Protein NDEL1_HUMAN with the residue 242 substituted with Phosphoserine" [UniProtKB:Q9GZM8] comment: by CDC2; xref: UniProtKB:Q9GZM8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005926 ! NDEL1_HUMAN [Term] id: CCO:B0013138 name: NDEL1_HUMAN-Phosphothreonine245 def: "Protein NDEL1_HUMAN with the residue 245 substituted with Phosphothreonine" [UniProtKB:Q9GZM8] comment: by CDC2 and MAPK1; xref: UniProtKB:Q9GZM8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005926 ! NDEL1_HUMAN [Term] id: CCO:B0013139 name: NEB2_HUMAN-Phosphoserine15 def: "Protein NEB2_HUMAN with the residue 15 substituted with Phosphoserine" [UniProtKB:Q96SB3] comment: By similarity xref: UniProtKB:Q96SB3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002060 ! NEB2_HUMAN [Term] id: CCO:B0013140 name: NEB2_HUMAN-Phosphoserine17 def: "Protein NEB2_HUMAN with the residue 17 substituted with Phosphoserine" [UniProtKB:Q96SB3] comment: By similarity xref: UniProtKB:Q96SB3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002060 ! NEB2_HUMAN [Term] id: CCO:B0013141 name: NEB2_HUMAN-Phosphoserine94 def: "Protein NEB2_HUMAN with the residue 94 substituted with Phosphoserine" [UniProtKB:Q96SB3] comment: By similarity xref: UniProtKB:Q96SB3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002060 ! NEB2_HUMAN [Term] id: CCO:B0013142 name: NEB2_HUMAN-Phosphoserine100 def: "Protein NEB2_HUMAN with the residue 100 substituted with Phosphoserine" [UniProtKB:Q96SB3] comment: By similarity xref: UniProtKB:Q96SB3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002060 ! NEB2_HUMAN [Term] id: CCO:B0013143 name: NEB2_HUMAN-Phosphoserine116 def: "Protein NEB2_HUMAN with the residue 116 substituted with Phosphoserine" [UniProtKB:Q96SB3] comment: By similarity xref: UniProtKB:Q96SB3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002060 ! NEB2_HUMAN [Term] id: CCO:B0013144 name: NEB2_HUMAN-Phosphoserine203 def: "Protein NEB2_HUMAN with the residue 203 substituted with Phosphoserine" [UniProtKB:Q96SB3] comment: By similarity xref: UniProtKB:Q96SB3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002060 ! NEB2_HUMAN [Term] id: CCO:B0013145 name: NEK1_HUMAN-Phosphothreonine162 def: "Protein NEK1_HUMAN with the residue 162 substituted with Phosphothreonine" [UniProtKB:Q96PY6] comment: by autocatalysis; By similarity xref: UniProtKB:Q96PY6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002055 ! NEK1_HUMAN [Term] id: CCO:B0013146 name: NEK1_HUMAN-Phosphoserine664 def: "Protein NEK1_HUMAN with the residue 664 substituted with Phosphoserine" [UniProtKB:Q96PY6] comment: By similarity xref: UniProtKB:Q96PY6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002055 ! NEK1_HUMAN [Term] id: CCO:B0013147 name: NEK1_HUMAN-Phosphoserine1126 def: "Protein NEK1_HUMAN with the residue 1126 substituted with Phosphoserine" [UniProtKB:Q96PY6] comment: By similarity xref: UniProtKB:Q96PY6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002055 ! NEK1_HUMAN [Term] id: CCO:B0013148 name: NEK2_HUMAN-Phosphothreonine175 def: "Protein NEK2_HUMAN with the residue 175 substituted with Phosphothreonine" [UniProtKB:P51955] comment: by autocatalysis; xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0013149 name: NEK4_HUMAN-Phosphothreonine165 def: "Protein NEK4_HUMAN with the residue 165 substituted with Phosphothreonine" [UniProtKB:P51957] comment: by autocatalysis; By similarity xref: UniProtKB:P51957 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001655 ! NEK4_HUMAN [Term] id: CCO:B0013150 name: NEK4_HUMAN-Phosphoserine563 def: "Protein NEK4_HUMAN with the residue 563 substituted with Phosphoserine" [UniProtKB:P51957] xref: UniProtKB:P51957 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001655 ! NEK4_HUMAN [Term] id: CCO:B0013151 name: NEK9_HUMAN-Phosphothreonine210 def: "Protein NEK9_HUMAN with the residue 210 substituted with Phosphothreonine" [UniProtKB:Q8TD19] comment: by autocatalysis; Probable xref: UniProtKB:Q8TD19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001991 ! NEK9_HUMAN [Term] id: CCO:B0013152 name: NEK9_HUMAN-Phosphoserine332 def: "Protein NEK9_HUMAN with the residue 332 substituted with Phosphoserine" [UniProtKB:Q8TD19] xref: UniProtKB:Q8TD19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001991 ! NEK9_HUMAN [Term] id: CCO:B0013153 name: NEK9_HUMAN-Phosphothreonine333 def: "Protein NEK9_HUMAN with the residue 333 substituted with Phosphothreonine" [UniProtKB:Q8TD19] xref: UniProtKB:Q8TD19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001991 ! NEK9_HUMAN [Term] id: CCO:B0013154 name: NEK9_HUMAN-Phosphothreonine358 def: "Protein NEK9_HUMAN with the residue 358 substituted with Phosphothreonine" [UniProtKB:Q8TD19] xref: UniProtKB:Q8TD19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001991 ! NEK9_HUMAN [Term] id: CCO:B0013155 name: NEK9_HUMAN-Phosphoserine868 def: "Protein NEK9_HUMAN with the residue 868 substituted with Phosphoserine" [UniProtKB:Q8TD19] xref: UniProtKB:Q8TD19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001991 ! NEK9_HUMAN [Term] id: CCO:B0013156 name: NEK9_HUMAN-Phosphoserine869 def: "Protein NEK9_HUMAN with the residue 869 substituted with Phosphoserine" [UniProtKB:Q8TD19] xref: UniProtKB:Q8TD19 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001991 ! NEK9_HUMAN [Term] id: CCO:B0013157 name: NELF_HUMAN-Phosphoserine288 def: "Protein NELF_HUMAN with the residue 288 substituted with Phosphoserine" [UniProtKB:Q6X4W1] xref: UniProtKB:Q6X4W1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005972 ! NELF_HUMAN [Term] id: CCO:B0013158 name: NEP1_HUMAN-N-acetylalanine2 def: "Protein NEP1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q92979] xref: UniProtKB:Q92979 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006260 ! NEP1_HUMAN [Term] id: CCO:B0013159 name: NF1_HUMAN-N-acetylalanine2 def: "Protein NF1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P21359] comment: By similarity xref: UniProtKB:P21359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001542 ! NF1_HUMAN [Term] id: CCO:B0013160 name: NF1_HUMAN-Phosphoserine864 def: "Protein NF1_HUMAN with the residue 864 substituted with Phosphoserine" [UniProtKB:P21359] xref: UniProtKB:P21359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001542 ! NF1_HUMAN [Term] id: CCO:B0013161 name: NF1_HUMAN-Phosphoserine2188 def: "Protein NF1_HUMAN with the residue 2188 substituted with Phosphoserine" [UniProtKB:P21359] xref: UniProtKB:P21359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001542 ! NF1_HUMAN [Term] id: CCO:B0013162 name: NF1_HUMAN-Phosphothreonine2514 def: "Protein NF1_HUMAN with the residue 2514 substituted with Phosphothreonine" [UniProtKB:P21359] comment: By similarity xref: UniProtKB:P21359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001542 ! NF1_HUMAN [Term] id: CCO:B0013163 name: NF1_HUMAN-Phosphoserine2515 def: "Protein NF1_HUMAN with the residue 2515 substituted with Phosphoserine" [UniProtKB:P21359] xref: UniProtKB:P21359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001542 ! NF1_HUMAN [Term] id: CCO:B0013169 name: NFL_HUMAN-N-acetylserine2 def: "Protein NFL_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P07196] comment: By similarity xref: UniProtKB:P07196 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006343 ! NFL_HUMAN [Term] id: CCO:B0013170 name: NFL_HUMAN-Phosphoserine56 def: "Protein NFL_HUMAN with the residue 56 substituted with Phosphoserine" [UniProtKB:P07196] comment: By similarity xref: UniProtKB:P07196 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006343 ! NFL_HUMAN [Term] id: CCO:B0013171 name: NFL_HUMAN-Phosphoserine67 def: "Protein NFL_HUMAN with the residue 67 substituted with Phosphoserine" [UniProtKB:P07196] comment: By similarity xref: UniProtKB:P07196 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006343 ! NFL_HUMAN [Term] id: CCO:B0013172 name: NFL_HUMAN-Phosphoserine472 def: "Protein NFL_HUMAN with the residue 472 substituted with Phosphoserine" [UniProtKB:P07196] xref: UniProtKB:P07196 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006343 ! NFL_HUMAN [Term] id: CCO:B0013173 name: NH2L1_HUMAN-N-acetylthreonine2 def: "Protein NH2L1_HUMAN with the residue 2 substituted with N-acetylthreonine" [UniProtKB:P55769] xref: UniProtKB:P55769 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001676 ! NH2L1_HUMAN [Term] id: CCO:B0013174 name: NIPA_HUMAN-Phosphoserine24 def: "Protein NIPA_HUMAN with the residue 24 substituted with Phosphoserine" [UniProtKB:Q86WB0] xref: UniProtKB:Q86WB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001941 ! NIPA_HUMAN [Term] id: CCO:B0013175 name: NIPA_HUMAN-Phosphothreonine28 def: "Protein NIPA_HUMAN with the residue 28 substituted with Phosphothreonine" [UniProtKB:Q86WB0] xref: UniProtKB:Q86WB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001941 ! NIPA_HUMAN [Term] id: CCO:B0013176 name: NIPA_HUMAN-Phosphoserine62 def: "Protein NIPA_HUMAN with the residue 62 substituted with Phosphoserine" [UniProtKB:Q86WB0] comment: By similarity xref: UniProtKB:Q86WB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001941 ! NIPA_HUMAN [Term] id: CCO:B0013177 name: NIPA_HUMAN-Phosphoserine321 def: "Protein NIPA_HUMAN with the residue 321 substituted with Phosphoserine" [UniProtKB:Q86WB0] xref: UniProtKB:Q86WB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001941 ! NIPA_HUMAN [Term] id: CCO:B0013178 name: NIPA_HUMAN-Phosphoserine354 def: "Protein NIPA_HUMAN with the residue 354 substituted with Phosphoserine" [UniProtKB:Q86WB0] xref: UniProtKB:Q86WB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001941 ! NIPA_HUMAN [Term] id: CCO:B0013179 name: NIPA_HUMAN-Phosphoserine370 def: "Protein NIPA_HUMAN with the residue 370 substituted with Phosphoserine" [UniProtKB:Q86WB0] comment: By similarity xref: UniProtKB:Q86WB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001941 ! NIPA_HUMAN [Term] id: CCO:B0013180 name: NIPBL_HUMAN-Phosphoserine280 def: "Protein NIPBL_HUMAN with the residue 280 substituted with Phosphoserine" [UniProtKB:Q6KC79] comment: By similarity xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013181 name: NIPBL_HUMAN-Phosphoserine318 def: "Protein NIPBL_HUMAN with the residue 318 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013182 name: NIPBL_HUMAN-Phosphoserine553 def: "Protein NIPBL_HUMAN with the residue 553 substituted with Phosphoserine" [UniProtKB:Q6KC79] comment: By similarity xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013183 name: NIPBL_HUMAN-Phosphothreonine558 def: "Protein NIPBL_HUMAN with the residue 558 substituted with Phosphothreonine" [UniProtKB:Q6KC79] comment: By similarity xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013184 name: NIPBL_HUMAN-Phosphothreonine646 def: "Protein NIPBL_HUMAN with the residue 646 substituted with Phosphothreonine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013185 name: NIPBL_HUMAN-Phosphothreonine746 def: "Protein NIPBL_HUMAN with the residue 746 substituted with Phosphothreonine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013186 name: NIPBL_HUMAN-Phosphoserine849 def: "Protein NIPBL_HUMAN with the residue 849 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013187 name: NIPBL_HUMAN-Phosphoserine850 def: "Protein NIPBL_HUMAN with the residue 850 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013188 name: NIPBL_HUMAN-Phosphoserine912 def: "Protein NIPBL_HUMAN with the residue 912 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013189 name: NIPBL_HUMAN-Phosphothreonine914 def: "Protein NIPBL_HUMAN with the residue 914 substituted with Phosphothreonine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013190 name: NIPBL_HUMAN-Phosphoserine1089 def: "Protein NIPBL_HUMAN with the residue 1089 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013191 name: NIPBL_HUMAN-Phosphoserine1090 def: "Protein NIPBL_HUMAN with the residue 1090 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013192 name: NIPBL_HUMAN-Phosphoserine1096 def: "Protein NIPBL_HUMAN with the residue 1096 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013193 name: NIPBL_HUMAN-Phosphoserine1150 def: "Protein NIPBL_HUMAN with the residue 1150 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013194 name: NIPBL_HUMAN-Phosphoserine1152 def: "Protein NIPBL_HUMAN with the residue 1152 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013195 name: NIPBL_HUMAN-Phosphoserine1154 def: "Protein NIPBL_HUMAN with the residue 1154 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013196 name: NIPBL_HUMAN-Phosphotyrosine1159 def: "Protein NIPBL_HUMAN with the residue 1159 substituted with Phosphotyrosine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013197 name: NIPBL_HUMAN-Phosphoserine2658 def: "Protein NIPBL_HUMAN with the residue 2658 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013198 name: NIPBL_HUMAN-Phosphothreonine2667 def: "Protein NIPBL_HUMAN with the residue 2667 substituted with Phosphothreonine" [UniProtKB:Q6KC79] comment: By similarity xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013199 name: NIPBL_HUMAN-Phosphoserine2672 def: "Protein NIPBL_HUMAN with the residue 2672 substituted with Phosphoserine" [UniProtKB:Q6KC79] xref: UniProtKB:Q6KC79 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001908 ! NIPBL_HUMAN [Term] id: CCO:B0013200 name: NOG1_HUMAN-N-acetylalanine2 def: "Protein NOG1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9BZE4] xref: UniProtKB:Q9BZE4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002116 ! NOG1_HUMAN [Term] id: CCO:B0013201 name: NOG1_HUMAN-Phosphoserine468 def: "Protein NOG1_HUMAN with the residue 468 substituted with Phosphoserine" [UniProtKB:Q9BZE4] xref: UniProtKB:Q9BZE4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002116 ! NOG1_HUMAN [Term] id: CCO:B0013202 name: NOG1_HUMAN-Phosphoserine470 def: "Protein NOG1_HUMAN with the residue 470 substituted with Phosphoserine" [UniProtKB:Q9BZE4] xref: UniProtKB:Q9BZE4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002116 ! NOG1_HUMAN [Term] id: CCO:B0013203 name: NOG1_HUMAN-Phosphoserine472 def: "Protein NOG1_HUMAN with the residue 472 substituted with Phosphoserine" [UniProtKB:Q9BZE4] xref: UniProtKB:Q9BZE4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002116 ! NOG1_HUMAN [Term] id: CCO:B0013204 name: NOL12_HUMAN-Phosphothreonine124 def: "Protein NOL12_HUMAN with the residue 124 substituted with Phosphothreonine" [UniProtKB:Q9UGY1] xref: UniProtKB:Q9UGY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006336 ! NOL12_HUMAN [Term] id: CCO:B0013205 name: NOL12_HUMAN-Phosphoserine139 def: "Protein NOL12_HUMAN with the residue 139 substituted with Phosphoserine" [UniProtKB:Q9UGY1] xref: UniProtKB:Q9UGY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006336 ! NOL12_HUMAN [Term] id: CCO:B0013206 name: NOL12_HUMAN-Phosphoserine140 def: "Protein NOL12_HUMAN with the residue 140 substituted with Phosphoserine" [UniProtKB:Q9UGY1] xref: UniProtKB:Q9UGY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006336 ! NOL12_HUMAN [Term] id: CCO:B0013207 name: NOL12_HUMAN-Phosphothreonine141 def: "Protein NOL12_HUMAN with the residue 141 substituted with Phosphothreonine" [UniProtKB:Q9UGY1] xref: UniProtKB:Q9UGY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006336 ! NOL12_HUMAN [Term] id: CCO:B0013221 name: NOLC1_HUMAN-Phosphoserine83 def: "Protein NOLC1_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013222 name: NOLC1_HUMAN-Phosphoserine84 def: "Protein NOLC1_HUMAN with the residue 84 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013223 name: NOLC1_HUMAN-Phosphoserine85 def: "Protein NOLC1_HUMAN with the residue 85 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013224 name: NOLC1_HUMAN-Phosphoserine87 def: "Protein NOLC1_HUMAN with the residue 87 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013225 name: NOLC1_HUMAN-Phosphoserine90 def: "Protein NOLC1_HUMAN with the residue 90 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013226 name: NOLC1_HUMAN-Phosphoserine91 def: "Protein NOLC1_HUMAN with the residue 91 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013227 name: NOLC1_HUMAN-Phosphoserine397 def: "Protein NOLC1_HUMAN with the residue 397 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013228 name: NOLC1_HUMAN-Phosphoserine508 def: "Protein NOLC1_HUMAN with the residue 508 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013229 name: NOLC1_HUMAN-Phosphoserine538 def: "Protein NOLC1_HUMAN with the residue 538 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013230 name: NOLC1_HUMAN-Phosphoserine563 def: "Protein NOLC1_HUMAN with the residue 563 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013231 name: NOLC1_HUMAN-Phosphothreonine607 def: "Protein NOLC1_HUMAN with the residue 607 substituted with Phosphothreonine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013232 name: NOLC1_HUMAN-Phosphothreonine610 def: "Protein NOLC1_HUMAN with the residue 610 substituted with Phosphothreonine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013233 name: NOLC1_HUMAN-Phosphoserine623 def: "Protein NOLC1_HUMAN with the residue 623 substituted with Phosphoserine" [UniProtKB:Q14978] comment: By similarity xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013234 name: NOLC1_HUMAN-Phosphoserine643 def: "Protein NOLC1_HUMAN with the residue 643 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013235 name: NOLC1_HUMAN-Phosphoserine698 def: "Protein NOLC1_HUMAN with the residue 698 substituted with Phosphoserine" [UniProtKB:Q14978] xref: UniProtKB:Q14978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001793 ! NOLC1_HUMAN [Term] id: CCO:B0013236 name: NONO_HUMAN-Phosphothreonine428 def: "Protein NONO_HUMAN with the residue 428 substituted with Phosphothreonine" [UniProtKB:Q15233] xref: UniProtKB:Q15233 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005234 ! NONO_HUMAN [Term] id: CCO:B0013237 name: NONO_HUMAN-Phosphothreonine450 def: "Protein NONO_HUMAN with the residue 450 substituted with Phosphothreonine" [UniProtKB:Q15233] xref: UniProtKB:Q15233 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005234 ! NONO_HUMAN [Term] id: CCO:B0013238 name: NOTC2_HUMAN-Phosphothreonine1808 def: "Protein NOTC2_HUMAN with the residue 1808 substituted with Phosphothreonine" [UniProtKB:Q04721] xref: UniProtKB:Q04721 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001719 ! NOTC2_HUMAN [Term] id: CCO:B0013239 name: NOTC2_HUMAN-Phosphoserine1841 def: "Protein NOTC2_HUMAN with the residue 1841 substituted with Phosphoserine" [UniProtKB:Q04721] xref: UniProtKB:Q04721 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001719 ! NOTC2_HUMAN [Term] id: CCO:B0013240 name: NOTC2_HUMAN-Phosphoserine1842 def: "Protein NOTC2_HUMAN with the residue 1842 substituted with Phosphoserine" [UniProtKB:Q04721] xref: UniProtKB:Q04721 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001719 ! NOTC2_HUMAN [Term] id: CCO:B0013241 name: NOTC2_HUMAN-Phosphoserine1845 def: "Protein NOTC2_HUMAN with the residue 1845 substituted with Phosphoserine" [UniProtKB:Q04721] xref: UniProtKB:Q04721 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001719 ! NOTC2_HUMAN [Term] id: CCO:B0013242 name: NOTC2_HUMAN-Phosphoserine2070 def: "Protein NOTC2_HUMAN with the residue 2070 substituted with Phosphoserine" [UniProtKB:Q04721] xref: UniProtKB:Q04721 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001719 ! NOTC2_HUMAN [Term] id: CCO:B0013243 name: NOTC2_HUMAN-Phosphoserine2078 def: "Protein NOTC2_HUMAN with the residue 2078 substituted with Phosphoserine" [UniProtKB:Q04721] comment: By similarity xref: UniProtKB:Q04721 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001719 ! NOTC2_HUMAN [Term] id: CCO:B0013244 name: NP1L1_HUMAN-Phosphoserine10 def: "Protein NP1L1_HUMAN with the residue 10 substituted with Phosphoserine" [UniProtKB:P55209] xref: UniProtKB:P55209 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005376 ! NP1L1_HUMAN [Term] id: CCO:B0013245 name: NP1L1_HUMAN-Phosphothreonine62 def: "Protein NP1L1_HUMAN with the residue 62 substituted with Phosphothreonine" [UniProtKB:P55209] xref: UniProtKB:P55209 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005376 ! NP1L1_HUMAN [Term] id: CCO:B0013246 name: NPM_HUMAN-Phosphoserine4 def: "Protein NPM_HUMAN with the residue 4 substituted with Phosphoserine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013247 name: NPM_HUMAN-Phosphoserine10 def: "Protein NPM_HUMAN with the residue 10 substituted with Phosphoserine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013248 name: NPM_HUMAN-Phosphoserine70 def: "Protein NPM_HUMAN with the residue 70 substituted with Phosphoserine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013249 name: NPM_HUMAN-Phosphothreonine75 def: "Protein NPM_HUMAN with the residue 75 substituted with Phosphothreonine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013250 name: NPM_HUMAN-Phosphothreonine95 def: "Protein NPM_HUMAN with the residue 95 substituted with Phosphothreonine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013251 name: NPM_HUMAN-Phosphoserine106 def: "Protein NPM_HUMAN with the residue 106 substituted with Phosphoserine" [UniProtKB:P06748] comment: By similarity xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013252 name: NPM_HUMAN-Phosphoserine125 def: "Protein NPM_HUMAN with the residue 125 substituted with Phosphoserine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013253 name: NPM_HUMAN-Phosphoserine137 def: "Protein NPM_HUMAN with the residue 137 substituted with Phosphoserine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013254 name: NPM_HUMAN-N6-acetyllysine150 def: "Protein NPM_HUMAN with the residue 150 substituted with N6-acetyllysine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013255 name: NPM_HUMAN-N6-acetyllysine154 def: "Protein NPM_HUMAN with the residue 154 substituted with N6-acetyllysine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013256 name: NPM_HUMAN-Phosphothreonine199 def: "Protein NPM_HUMAN with the residue 199 substituted with Phosphothreonine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013257 name: NPM_HUMAN-N6-acetyllysine212 def: "Protein NPM_HUMAN with the residue 212 substituted with N6-acetyllysine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013258 name: NPM_HUMAN-Phosphothreonine234 def: "Protein NPM_HUMAN with the residue 234 substituted with Phosphothreonine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013259 name: NPM_HUMAN-Phosphothreonine237 def: "Protein NPM_HUMAN with the residue 237 substituted with Phosphothreonine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013260 name: NPM_HUMAN-Phosphoserine254 def: "Protein NPM_HUMAN with the residue 254 substituted with Phosphoserine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013261 name: NPM_HUMAN-Phosphoserine260 def: "Protein NPM_HUMAN with the residue 260 substituted with Phosphoserine" [UniProtKB:P06748] xref: UniProtKB:P06748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:B0013262 name: NSL1_HUMAN-Phosphoserine24 def: "Protein NSL1_HUMAN with the residue 24 substituted with Phosphoserine" [UniProtKB:Q96IY1] xref: UniProtKB:Q96IY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002043 ! NSL1_HUMAN [Term] id: CCO:B0013263 name: NSL1_HUMAN-Phosphothreonine242 def: "Protein NSL1_HUMAN with the residue 242 substituted with Phosphothreonine" [UniProtKB:Q96IY1] xref: UniProtKB:Q96IY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002043 ! NSL1_HUMAN [Term] id: CCO:B0013264 name: NUAK2_HUMAN-Phosphothreonine208 def: "Protein NUAK2_HUMAN with the residue 208 substituted with Phosphothreonine" [UniProtKB:Q9H093] xref: UniProtKB:Q9H093 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005874 ! NUAK2_HUMAN [Term] id: CCO:B0013265 name: NUAK2_HUMAN-Phosphoserine212 def: "Protein NUAK2_HUMAN with the residue 212 substituted with Phosphoserine" [UniProtKB:Q9H093] comment: By similarity xref: UniProtKB:Q9H093 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005874 ! NUAK2_HUMAN [Term] id: CCO:B0013266 name: NUAK2_HUMAN-Phosphoserine377 def: "Protein NUAK2_HUMAN with the residue 377 substituted with Phosphoserine" [UniProtKB:Q9H093] comment: By similarity xref: UniProtKB:Q9H093 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005874 ! NUAK2_HUMAN [Term] id: CCO:B0013267 name: NUAK2_HUMAN-Phosphoserine386 def: "Protein NUAK2_HUMAN with the residue 386 substituted with Phosphoserine" [UniProtKB:Q9H093] comment: By similarity xref: UniProtKB:Q9H093 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005874 ! NUAK2_HUMAN [Term] id: CCO:B0013268 name: NUAK2_HUMAN-Phosphoserine585 def: "Protein NUAK2_HUMAN with the residue 585 substituted with Phosphoserine" [UniProtKB:Q9H093] comment: By similarity xref: UniProtKB:Q9H093 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005874 ! NUAK2_HUMAN [Term] id: CCO:B0013269 name: NUCL_HUMAN-Phosphoserine28 def: "Protein NUCL_HUMAN with the residue 28 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013270 name: NUCL_HUMAN-Phosphoserine34 def: "Protein NUCL_HUMAN with the residue 34 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013271 name: NUCL_HUMAN-Phosphoserine41 def: "Protein NUCL_HUMAN with the residue 41 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013272 name: NUCL_HUMAN-Phosphoserine42 def: "Protein NUCL_HUMAN with the residue 42 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013273 name: NUCL_HUMAN-Phosphoserine67 def: "Protein NUCL_HUMAN with the residue 67 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013274 name: NUCL_HUMAN-Phosphothreonine69 def: "Protein NUCL_HUMAN with the residue 69 substituted with Phosphothreonine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013275 name: NUCL_HUMAN-Phosphothreonine76 def: "Protein NUCL_HUMAN with the residue 76 substituted with Phosphothreonine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013276 name: NUCL_HUMAN-Phosphothreonine121 def: "Protein NUCL_HUMAN with the residue 121 substituted with Phosphothreonine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013277 name: NUCL_HUMAN-Phosphoserine145 def: "Protein NUCL_HUMAN with the residue 145 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013278 name: NUCL_HUMAN-Phosphoserine153 def: "Protein NUCL_HUMAN with the residue 153 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013279 name: NUCL_HUMAN-Phosphoserine184 def: "Protein NUCL_HUMAN with the residue 184 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013280 name: NUCL_HUMAN-Phosphothreonine214 def: "Protein NUCL_HUMAN with the residue 214 substituted with Phosphothreonine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013281 name: NUCL_HUMAN-Phosphoserine563 def: "Protein NUCL_HUMAN with the residue 563 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013282 name: NUCL_HUMAN-Phosphoserine580 def: "Protein NUCL_HUMAN with the residue 580 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013283 name: NUCL_HUMAN-Phosphoserine619 def: "Protein NUCL_HUMAN with the residue 619 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0013284 name: NUDC3_HUMAN-Phosphoserine146 def: "Protein NUDC3_HUMAN with the residue 146 substituted with Phosphoserine" [UniProtKB:Q8IVD9] xref: UniProtKB:Q8IVD9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005198 ! NUDC3_HUMAN [Term] id: CCO:B0013285 name: NUDC3_HUMAN-Phosphoserine340 def: "Protein NUDC3_HUMAN with the residue 340 substituted with Phosphoserine" [UniProtKB:Q8IVD9] xref: UniProtKB:Q8IVD9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005198 ! NUDC3_HUMAN [Term] id: CCO:B0013286 name: NUDC_HUMAN-Phosphoserine139 def: "Protein NUDC_HUMAN with the residue 139 substituted with Phosphoserine" [UniProtKB:Q9Y266] xref: UniProtKB:Q9Y266 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002250 ! NUDC_HUMAN [Term] id: CCO:B0013287 name: NUDC_HUMAN-Phosphothreonine145 def: "Protein NUDC_HUMAN with the residue 145 substituted with Phosphothreonine" [UniProtKB:Q9Y266] xref: UniProtKB:Q9Y266 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002250 ! NUDC_HUMAN [Term] id: CCO:B0013288 name: NUDC_HUMAN-Phosphoserine274 def: "Protein NUDC_HUMAN with the residue 274 substituted with Phosphoserine" [UniProtKB:Q9Y266] comment: by PLK1; xref: UniProtKB:Q9Y266 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002250 ! NUDC_HUMAN [Term] id: CCO:B0013289 name: NUDC_HUMAN-Phosphoserine285 def: "Protein NUDC_HUMAN with the residue 285 substituted with Phosphoserine" [UniProtKB:Q9Y266] xref: UniProtKB:Q9Y266 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002250 ! NUDC_HUMAN [Term] id: CCO:B0013290 name: NUDC_HUMAN-Phosphoserine326 def: "Protein NUDC_HUMAN with the residue 326 substituted with Phosphoserine" [UniProtKB:Q9Y266] comment: by PLK1; xref: UniProtKB:Q9Y266 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002250 ! NUDC_HUMAN [Term] id: CCO:B0013291 name: NUF2_HUMAN-Phosphoserine247 def: "Protein NUF2_HUMAN with the residue 247 substituted with Phosphoserine" [UniProtKB:Q9BZD4] xref: UniProtKB:Q9BZD4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002115 ! NUF2_HUMAN [Term] id: CCO:B0013292 name: NUF2_HUMAN-Phosphothreonine261 def: "Protein NUF2_HUMAN with the residue 261 substituted with Phosphothreonine" [UniProtKB:Q9BZD4] xref: UniProtKB:Q9BZD4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002115 ! NUF2_HUMAN [Term] id: CCO:B0013293 name: NUMA1_HUMAN-Phosphoserine169 def: "Protein NUMA1_HUMAN with the residue 169 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013294 name: NUMA1_HUMAN-Phosphoserine172 def: "Protein NUMA1_HUMAN with the residue 172 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013295 name: NUMA1_HUMAN-Phosphoserine200 def: "Protein NUMA1_HUMAN with the residue 200 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013296 name: NUMA1_HUMAN-Phosphoserine203 def: "Protein NUMA1_HUMAN with the residue 203 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013297 name: NUMA1_HUMAN-Phosphothreonine211 def: "Protein NUMA1_HUMAN with the residue 211 substituted with Phosphothreonine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013298 name: NUMA1_HUMAN-Phosphoserine388 def: "Protein NUMA1_HUMAN with the residue 388 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013299 name: NUMA1_HUMAN-Phosphoserine395 def: "Protein NUMA1_HUMAN with the residue 395 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013300 name: NUMA1_HUMAN-Phosphoserine820 def: "Protein NUMA1_HUMAN with the residue 820 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013301 name: NUMA1_HUMAN-Phosphothreonine963 def: "Protein NUMA1_HUMAN with the residue 963 substituted with Phosphothreonine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013302 name: NUMA1_HUMAN-Phosphoserine1262 def: "Protein NUMA1_HUMAN with the residue 1262 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013303 name: NUMA1_HUMAN-Phosphoserine1601 def: "Protein NUMA1_HUMAN with the residue 1601 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013304 name: NUMA1_HUMAN-Phosphoserine1721 def: "Protein NUMA1_HUMAN with the residue 1721 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013305 name: NUMA1_HUMAN-Phosphoserine1724 def: "Protein NUMA1_HUMAN with the residue 1724 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013306 name: NUMA1_HUMAN-Phosphoserine1728 def: "Protein NUMA1_HUMAN with the residue 1728 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013307 name: NUMA1_HUMAN-Phosphothreonine1733 def: "Protein NUMA1_HUMAN with the residue 1733 substituted with Phosphothreonine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013308 name: NUMA1_HUMAN-Phosphoserine1757 def: "Protein NUMA1_HUMAN with the residue 1757 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013309 name: NUMA1_HUMAN-Phosphoserine1760 def: "Protein NUMA1_HUMAN with the residue 1760 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013310 name: NUMA1_HUMAN-Phosphoserine1769 def: "Protein NUMA1_HUMAN with the residue 1769 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013311 name: NUMA1_HUMAN-Phosphoserine1772 def: "Protein NUMA1_HUMAN with the residue 1772 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013312 name: NUMA1_HUMAN-Phosphotyrosine1774 def: "Protein NUMA1_HUMAN with the residue 1774 substituted with Phosphotyrosine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013313 name: NUMA1_HUMAN-Phosphothreonine1776 def: "Protein NUMA1_HUMAN with the residue 1776 substituted with Phosphothreonine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013314 name: NUMA1_HUMAN-Phosphoserine1830 def: "Protein NUMA1_HUMAN with the residue 1830 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013315 name: NUMA1_HUMAN-Phosphoserine1833 def: "Protein NUMA1_HUMAN with the residue 1833 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013316 name: NUMA1_HUMAN-Phosphoserine1834 def: "Protein NUMA1_HUMAN with the residue 1834 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013317 name: NUMA1_HUMAN-Phosphoserine1840 def: "Protein NUMA1_HUMAN with the residue 1840 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013318 name: NUMA1_HUMAN-Phosphoserine1847 def: "Protein NUMA1_HUMAN with the residue 1847 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013319 name: NUMA1_HUMAN-Phosphoserine1853 def: "Protein NUMA1_HUMAN with the residue 1853 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013320 name: NUMA1_HUMAN-Phosphoserine1862 def: "Protein NUMA1_HUMAN with the residue 1862 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013321 name: NUMA1_HUMAN-Phosphoserine1872 def: "Protein NUMA1_HUMAN with the residue 1872 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013322 name: NUMA1_HUMAN-Phosphoserine1945 def: "Protein NUMA1_HUMAN with the residue 1945 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013323 name: NUMA1_HUMAN-Phosphothreonine2000 def: "Protein NUMA1_HUMAN with the residue 2000 substituted with Phosphothreonine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013324 name: NUMA1_HUMAN-Phosphothreonine2055 def: "Protein NUMA1_HUMAN with the residue 2055 substituted with Phosphothreonine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013325 name: NUMA1_HUMAN-Phosphoserine2077 def: "Protein NUMA1_HUMAN with the residue 2077 substituted with Phosphoserine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001484 ! structural molecule activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000144 ! spindle pole relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000436 ! spindle microtubule relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013326 name: NUMA1_HUMAN-Phosphothreonine2106 def: "Protein NUMA1_HUMAN with the residue 2106 substituted with Phosphothreonine" [UniProtKB:Q14980] xref: UniProtKB:Q14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001794 ! NUMA1_HUMAN [Term] id: CCO:B0013327 name: NUSAP_HUMAN-Phosphoserine124 def: "Protein NUSAP_HUMAN with the residue 124 substituted with Phosphoserine" [UniProtKB:Q9BXS6] xref: UniProtKB:Q9BXS6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002108 ! NUSAP_HUMAN [Term] id: CCO:B0013328 name: NUSAP_HUMAN-Phosphoserine135 def: "Protein NUSAP_HUMAN with the residue 135 substituted with Phosphoserine" [UniProtKB:Q9BXS6] xref: UniProtKB:Q9BXS6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002108 ! NUSAP_HUMAN [Term] id: CCO:B0013329 name: NUSAP_HUMAN-Phosphothreonine314 def: "Protein NUSAP_HUMAN with the residue 314 substituted with Phosphothreonine" [UniProtKB:Q9BXS6] xref: UniProtKB:Q9BXS6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002108 ! NUSAP_HUMAN [Term] id: CCO:B0013330 name: ORC1_HUMAN-Phosphoserine417 def: "Protein ORC1_HUMAN with the residue 417 substituted with Phosphoserine" [UniProtKB:Q13415] xref: UniProtKB:Q13415 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005352 ! ORC1_HUMAN [Term] id: CCO:B0013331 name: ORC1_HUMAN-Phosphoserine419 def: "Protein ORC1_HUMAN with the residue 419 substituted with Phosphoserine" [UniProtKB:Q13415] xref: UniProtKB:Q13415 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005352 ! ORC1_HUMAN [Term] id: CCO:B0013332 name: ORC1_HUMAN-Phosphoserine420 def: "Protein ORC1_HUMAN with the residue 420 substituted with Phosphoserine" [UniProtKB:Q13415] xref: UniProtKB:Q13415 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005352 ! ORC1_HUMAN [Term] id: CCO:B0013333 name: ORC1_HUMAN-Phosphoserine421 def: "Protein ORC1_HUMAN with the residue 421 substituted with Phosphoserine" [UniProtKB:Q13415] xref: UniProtKB:Q13415 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005352 ! ORC1_HUMAN [Term] id: CCO:B0013334 name: ORC3_HUMAN-Phosphoserine208 def: "Protein ORC3_HUMAN with the residue 208 substituted with Phosphoserine" [UniProtKB:Q9UBD5] xref: UniProtKB:Q9UBD5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005392 ! ORC3_HUMAN [Term] id: CCO:B0013335 name: ORC3_HUMAN-Phosphoserine516 def: "Protein ORC3_HUMAN with the residue 516 substituted with Phosphoserine" [UniProtKB:Q9UBD5] xref: UniProtKB:Q9UBD5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005392 ! ORC3_HUMAN [Term] id: CCO:B0013336 name: ORC6_HUMAN-Phosphothreonine195 def: "Protein ORC6_HUMAN with the residue 195 substituted with Phosphothreonine" [UniProtKB:Q9Y5N6] xref: UniProtKB:Q9Y5N6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005388 ! ORC6_HUMAN [Term] id: CCO:B0013337 name: ORC6_HUMAN-Phosphothreonine229 def: "Protein ORC6_HUMAN with the residue 229 substituted with Phosphothreonine" [UniProtKB:Q9Y5N6] xref: UniProtKB:Q9Y5N6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005388 ! ORC6_HUMAN [Term] id: CCO:B0013338 name: OSBL1_HUMAN-Phosphoserine499 def: "Protein OSBL1_HUMAN with the residue 499 substituted with Phosphoserine" [UniProtKB:Q9BXW6] xref: UniProtKB:Q9BXW6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006009 ! OSBL1_HUMAN [Term] id: CCO:B0013339 name: P3C2A_HUMAN-Phosphoserine259 def: "Protein P3C2A_HUMAN with the residue 259 substituted with Phosphoserine" [UniProtKB:O00443] xref: UniProtKB:O00443 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006071 ! P3C2A_HUMAN [Term] id: CCO:B0013340 name: P53_HUMAN-Phosphoserine15 def: "Protein P53_HUMAN with the residue 15 substituted with Phosphoserine" [UniProtKB:P04637] comment: by PRPK; xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013341 name: P53_HUMAN-Phosphothreonine18 def: "Protein P53_HUMAN with the residue 18 substituted with Phosphothreonine" [UniProtKB:P04637] comment: by VRK1; xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013342 name: P53_HUMAN-Phosphoserine46 def: "Protein P53_HUMAN with the residue 46 substituted with Phosphoserine" [UniProtKB:P04637] comment: by HIPK2; xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013343 name: P53_HUMAN-Phosphothreonine55 def: "Protein P53_HUMAN with the residue 55 substituted with Phosphothreonine" [UniProtKB:P04637] comment: by TAF1; xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013344 name: P53_HUMAN-Phosphoserine99 def: "Protein P53_HUMAN with the residue 99 substituted with Phosphoserine" [UniProtKB:P04637] xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013345 name: P53_HUMAN-N6-acetyllysine305 def: "Protein P53_HUMAN with the residue 305 substituted with N6-acetyllysine" [UniProtKB:P04637] xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013346 name: P53_HUMAN-Phosphoserine315 def: "Protein P53_HUMAN with the residue 315 substituted with Phosphoserine" [UniProtKB:P04637] comment: by CDC2; xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013347 name: P53_HUMAN-N6-acetyllysine373 def: "Protein P53_HUMAN with the residue 373 substituted with N6-acetyllysine" [UniProtKB:P04637] xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013348 name: P53_HUMAN-N6-acetyllysine382 def: "Protein P53_HUMAN with the residue 382 substituted with N6-acetyllysine" [UniProtKB:P04637] xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013349 name: P53_HUMAN-O-(5'-phospho-RNA)-serine392 def: "Protein P53_HUMAN with the residue 392 substituted with O-(5'-phospho-RNA)-serine" [UniProtKB:P04637] xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013350 name: P53_HUMAN-Phosphoserine392 def: "Protein P53_HUMAN with the residue 392 substituted with Phosphoserine" [UniProtKB:P04637] comment: by CK2; xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0013351 name: P66A_HUMAN-Phosphoserine100 def: "Protein P66A_HUMAN with the residue 100 substituted with Phosphoserine" [UniProtKB:Q86YP4] xref: UniProtKB:Q86YP4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005907 ! P66A_HUMAN [Term] id: CCO:B0013352 name: P66A_HUMAN-Phosphoserine107 def: "Protein P66A_HUMAN with the residue 107 substituted with Phosphoserine" [UniProtKB:Q86YP4] xref: UniProtKB:Q86YP4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005907 ! P66A_HUMAN [Term] id: CCO:B0013353 name: P66A_HUMAN-Phosphoserine114 def: "Protein P66A_HUMAN with the residue 114 substituted with Phosphoserine" [UniProtKB:Q86YP4] xref: UniProtKB:Q86YP4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005907 ! P66A_HUMAN [Term] id: CCO:B0013354 name: P66A_HUMAN-Phosphoserine546 def: "Protein P66A_HUMAN with the residue 546 substituted with Phosphoserine" [UniProtKB:Q86YP4] xref: UniProtKB:Q86YP4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005907 ! P66A_HUMAN [Term] id: CCO:B0013355 name: P66A_HUMAN-Phosphoserine598 def: "Protein P66A_HUMAN with the residue 598 substituted with Phosphoserine" [UniProtKB:Q86YP4] xref: UniProtKB:Q86YP4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005907 ! P66A_HUMAN [Term] id: CCO:B0013356 name: P66B_HUMAN-Phosphothreonine120 def: "Protein P66B_HUMAN with the residue 120 substituted with Phosphothreonine" [UniProtKB:Q8WXI9] xref: UniProtKB:Q8WXI9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005908 ! P66B_HUMAN [Term] id: CCO:B0013357 name: P66B_HUMAN-Phosphoserine122 def: "Protein P66B_HUMAN with the residue 122 substituted with Phosphoserine" [UniProtKB:Q8WXI9] xref: UniProtKB:Q8WXI9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005908 ! P66B_HUMAN [Term] id: CCO:B0013358 name: P66B_HUMAN-Phosphoserine129 def: "Protein P66B_HUMAN with the residue 129 substituted with Phosphoserine" [UniProtKB:Q8WXI9] xref: UniProtKB:Q8WXI9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005908 ! P66B_HUMAN [Term] id: CCO:B0013359 name: P66B_HUMAN-Phosphoserine135 def: "Protein P66B_HUMAN with the residue 135 substituted with Phosphoserine" [UniProtKB:Q8WXI9] xref: UniProtKB:Q8WXI9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005908 ! P66B_HUMAN [Term] id: CCO:B0013360 name: P66B_HUMAN-Phosphoserine486 def: "Protein P66B_HUMAN with the residue 486 substituted with Phosphoserine" [UniProtKB:Q8WXI9] xref: UniProtKB:Q8WXI9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005908 ! P66B_HUMAN [Term] id: CCO:B0013361 name: P73_HUMAN-Phosphotyrosine99 def: "Protein P73_HUMAN with the residue 99 substituted with Phosphotyrosine" [UniProtKB:O15350] comment: by ABL; in isoform Beta; xref: UniProtKB:O15350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001374 ! P73_HUMAN [Term] id: CCO:B0013362 name: P80C_HUMAN-Phosphothreonine122 def: "Protein P80C_HUMAN with the residue 122 substituted with Phosphothreonine" [UniProtKB:P38432] xref: UniProtKB:P38432 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005621 ! P80C_HUMAN [Term] id: CCO:B0013363 name: P80C_HUMAN-Phosphothreonine303 def: "Protein P80C_HUMAN with the residue 303 substituted with Phosphothreonine" [UniProtKB:P38432] xref: UniProtKB:P38432 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005621 ! P80C_HUMAN [Term] id: CCO:B0013364 name: P80C_HUMAN-Phosphoserine489 def: "Protein P80C_HUMAN with the residue 489 substituted with Phosphoserine" [UniProtKB:P38432] xref: UniProtKB:P38432 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005621 ! P80C_HUMAN [Term] id: CCO:B0013365 name: PA2G4_HUMAN-N-acetylserine2 def: "Protein PA2G4_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:Q9UQ80] comment: By similarity xref: UniProtKB:Q9UQ80 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:B0013366 name: PA2G4_HUMAN-Phosphoserine2 def: "Protein PA2G4_HUMAN with the residue 2 substituted with Phosphoserine" [UniProtKB:Q9UQ80] xref: UniProtKB:Q9UQ80 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:B0013367 name: PA2G4_HUMAN-Phosphothreonine366 def: "Protein PA2G4_HUMAN with the residue 366 substituted with Phosphothreonine" [UniProtKB:Q9UQ80] comment: Probable xref: UniProtKB:Q9UQ80 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:B0013368 name: PA2G4_HUMAN-Phosphothreonine386 def: "Protein PA2G4_HUMAN with the residue 386 substituted with Phosphothreonine" [UniProtKB:Q9UQ80] xref: UniProtKB:Q9UQ80 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:B0013369 name: PABP1_HUMAN-Phosphotyrosine364 def: "Protein PABP1_HUMAN with the residue 364 substituted with Phosphotyrosine" [UniProtKB:P11940] xref: UniProtKB:P11940 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005854 ! PABP1_HUMAN [Term] id: CCO:B0013370 name: PABP1_HUMAN-arginine455 def: "Protein PABP1_HUMAN with the residue 455 substituted with arginine" [UniProtKB:P11940] comment: by CARM1; partial; Probable xref: UniProtKB:P11940 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005854 ! PABP1_HUMAN [Term] id: CCO:B0013371 name: PABP1_HUMAN-arginine460 def: "Protein PABP1_HUMAN with the residue 460 substituted with arginine" [UniProtKB:P11940] comment: by CARM1; partial; Probable xref: UniProtKB:P11940 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005854 ! PABP1_HUMAN [Term] id: CCO:B0013372 name: PABP1_HUMAN-Omega-N-methylated arginine493 def: "Protein PABP1_HUMAN with the residue 493 substituted with Omega-N-methylated arginine" [UniProtKB:P11940] xref: UniProtKB:P11940 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005854 ! PABP1_HUMAN [Term] id: CCO:B0013375 name: PAK1_HUMAN-Phosphoserine21 def: "Protein PAK1_HUMAN with the residue 21 substituted with Phosphoserine" [UniProtKB:Q13153] comment: by autocatalysis; By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013376 name: PAK1_HUMAN-Phosphoserine57 def: "Protein PAK1_HUMAN with the residue 57 substituted with Phosphoserine" [UniProtKB:Q13153] comment: by autocatalysis; By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013377 name: PAK1_HUMAN-Phosphothreonine84 def: "Protein PAK1_HUMAN with the residue 84 substituted with Phosphothreonine" [UniProtKB:Q13153] comment: by OXSR1; By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013378 name: PAK1_HUMAN-Phosphoserine144 def: "Protein PAK1_HUMAN with the residue 144 substituted with Phosphoserine" [UniProtKB:Q13153] comment: by autocatalysis; By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013379 name: PAK1_HUMAN-Phosphoserine149 def: "Protein PAK1_HUMAN with the residue 149 substituted with Phosphoserine" [UniProtKB:Q13153] comment: by autocatalysis; By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013380 name: PAK1_HUMAN-Phosphoserine199 def: "Protein PAK1_HUMAN with the residue 199 substituted with Phosphoserine" [UniProtKB:Q13153] comment: by autocatalysis; By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013381 name: PAK1_HUMAN-Phosphoserine204 def: "Protein PAK1_HUMAN with the residue 204 substituted with Phosphoserine" [UniProtKB:Q13153] comment: by autocatalysis; By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013382 name: PAK1_HUMAN-Phosphothreonine212 def: "Protein PAK1_HUMAN with the residue 212 substituted with Phosphothreonine" [UniProtKB:Q13153] xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013383 name: PAK1_HUMAN-Phosphoserine220 def: "Protein PAK1_HUMAN with the residue 220 substituted with Phosphoserine" [UniProtKB:Q13153] comment: By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013384 name: PAK1_HUMAN-Phosphoserine223 def: "Protein PAK1_HUMAN with the residue 223 substituted with Phosphoserine" [UniProtKB:Q13153] comment: By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013385 name: PAK1_HUMAN-Phosphothreonine225 def: "Protein PAK1_HUMAN with the residue 225 substituted with Phosphothreonine" [UniProtKB:Q13153] comment: By similarity xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013386 name: PAK1_HUMAN-Phosphothreonine423 def: "Protein PAK1_HUMAN with the residue 423 substituted with Phosphothreonine" [UniProtKB:Q13153] comment: by autocatalysis; Probable xref: UniProtKB:Q13153 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:B0013387 name: PAR3L_HUMAN-Phosphoserine368 def: "Protein PAR3L_HUMAN with the residue 368 substituted with Phosphoserine" [UniProtKB:Q8TEW8] comment: By similarity xref: UniProtKB:Q8TEW8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001997 ! PAR3L_HUMAN [Term] id: CCO:B0013388 name: PAR3L_HUMAN-Phosphoserine730 def: "Protein PAR3L_HUMAN with the residue 730 substituted with Phosphoserine" [UniProtKB:Q8TEW8] comment: By similarity xref: UniProtKB:Q8TEW8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001997 ! PAR3L_HUMAN [Term] id: CCO:B0013389 name: PAR3L_HUMAN-Phosphoserine746 def: "Protein PAR3L_HUMAN with the residue 746 substituted with Phosphoserine" [UniProtKB:Q8TEW8] comment: By similarity xref: UniProtKB:Q8TEW8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001997 ! PAR3L_HUMAN [Term] id: CCO:B0013390 name: PAR3L_HUMAN-Phosphoserine749 def: "Protein PAR3L_HUMAN with the residue 749 substituted with Phosphoserine" [UniProtKB:Q8TEW8] comment: By similarity xref: UniProtKB:Q8TEW8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001997 ! PAR3L_HUMAN [Term] id: CCO:B0013391 name: PARD3_HUMAN-Phosphoserine144 def: "Protein PARD3_HUMAN with the residue 144 substituted with Phosphoserine" [UniProtKB:Q8TEW0] xref: UniProtKB:Q8TEW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001996 ! PARD3_HUMAN [Term] id: CCO:B0013392 name: PARD3_HUMAN-Phosphoserine383 def: "Protein PARD3_HUMAN with the residue 383 substituted with Phosphoserine" [UniProtKB:Q8TEW0] xref: UniProtKB:Q8TEW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001996 ! PARD3_HUMAN [Term] id: CCO:B0013393 name: PARD3_HUMAN-Phosphoserine717 def: "Protein PARD3_HUMAN with the residue 717 substituted with Phosphoserine" [UniProtKB:Q8TEW0] comment: By similarity xref: UniProtKB:Q8TEW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001996 ! PARD3_HUMAN [Term] id: CCO:B0013394 name: PARD3_HUMAN-Phosphoserine827 def: "Protein PARD3_HUMAN with the residue 827 substituted with Phosphoserine" [UniProtKB:Q8TEW0] comment: By similarity xref: UniProtKB:Q8TEW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001996 ! PARD3_HUMAN [Term] id: CCO:B0013395 name: PARD3_HUMAN-Phosphotyrosine1127 def: "Protein PARD3_HUMAN with the residue 1127 substituted with Phosphotyrosine" [UniProtKB:Q8TEW0] xref: UniProtKB:Q8TEW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001996 ! PARD3_HUMAN [Term] id: CCO:B0013396 name: PARK7_HUMAN-Phosphotyrosine67 def: "Protein PARK7_HUMAN with the residue 67 substituted with Phosphotyrosine" [UniProtKB:Q99497] xref: UniProtKB:Q99497 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005443 ! PARK7_HUMAN [Term] id: CCO:B0013397 name: PARK7_HUMAN-Cysteine sulfinic acid (-SO2H)106 def: "Protein PARK7_HUMAN with the residue 106 substituted with Cysteine sulfinic acid (-SO2H)" [UniProtKB:Q99497] xref: UniProtKB:Q99497 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005443 ! PARK7_HUMAN [Term] id: CCO:B0013398 name: PARN_HUMAN-Phosphoserine163 def: "Protein PARN_HUMAN with the residue 163 substituted with Phosphoserine" [UniProtKB:O95453] xref: UniProtKB:O95453 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005347 ! PARN_HUMAN [Term] id: CCO:B0013399 name: PARN_HUMAN-Phosphoserine557 def: "Protein PARN_HUMAN with the residue 557 substituted with Phosphoserine" [UniProtKB:O95453] xref: UniProtKB:O95453 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005347 ! PARN_HUMAN [Term] id: CCO:B0013400 name: PARN_HUMAN-Phosphoserine587 def: "Protein PARN_HUMAN with the residue 587 substituted with Phosphoserine" [UniProtKB:O95453] comment: By similarity xref: UniProtKB:O95453 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005347 ! PARN_HUMAN [Term] id: CCO:B0013401 name: PARN_HUMAN-Phosphoserine619 def: "Protein PARN_HUMAN with the residue 619 substituted with Phosphoserine" [UniProtKB:O95453] xref: UniProtKB:O95453 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005347 ! PARN_HUMAN [Term] id: CCO:B0013418 name: PAXI_HUMAN-Phosphotyrosine31 def: "Protein PAXI_HUMAN with the residue 31 substituted with Phosphotyrosine" [UniProtKB:P49023] xref: UniProtKB:P49023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005837 ! PAXI_HUMAN [Term] id: CCO:B0013419 name: PAXI_HUMAN-Phosphotyrosine88 def: "Protein PAXI_HUMAN with the residue 88 substituted with Phosphotyrosine" [UniProtKB:P49023] xref: UniProtKB:P49023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005837 ! PAXI_HUMAN [Term] id: CCO:B0013420 name: PAXI_HUMAN-Phosphoserine106 def: "Protein PAXI_HUMAN with the residue 106 substituted with Phosphoserine" [UniProtKB:P49023] xref: UniProtKB:P49023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005837 ! PAXI_HUMAN [Term] id: CCO:B0013421 name: PAXI_HUMAN-Phosphoserine109 def: "Protein PAXI_HUMAN with the residue 109 substituted with Phosphoserine" [UniProtKB:P49023] comment: By similarity xref: UniProtKB:P49023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005837 ! PAXI_HUMAN [Term] id: CCO:B0013422 name: PAXI_HUMAN-Phosphotyrosine118 def: "Protein PAXI_HUMAN with the residue 118 substituted with Phosphotyrosine" [UniProtKB:P49023] xref: UniProtKB:P49023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005837 ! PAXI_HUMAN [Term] id: CCO:B0013423 name: PAXI_HUMAN-Phosphotyrosine181 def: "Protein PAXI_HUMAN with the residue 181 substituted with Phosphotyrosine" [UniProtKB:P49023] xref: UniProtKB:P49023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005837 ! PAXI_HUMAN [Term] id: CCO:B0013424 name: PAXI_HUMAN-Phosphoserine303 def: "Protein PAXI_HUMAN with the residue 303 substituted with Phosphoserine" [UniProtKB:P49023] xref: UniProtKB:P49023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005837 ! PAXI_HUMAN [Term] id: CCO:B0013425 name: PB1_HUMAN-Phosphoserine39 def: "Protein PB1_HUMAN with the residue 39 substituted with Phosphoserine" [UniProtKB:Q86U86] xref: UniProtKB:Q86U86 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001938 ! PB1_HUMAN [Term] id: CCO:B0013426 name: PB1_HUMAN-Phosphotyrosine54 def: "Protein PB1_HUMAN with the residue 54 substituted with Phosphotyrosine" [UniProtKB:Q86U86] xref: UniProtKB:Q86U86 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001938 ! PB1_HUMAN [Term] id: CCO:B0013427 name: PB1_HUMAN-Phosphothreonine301 def: "Protein PB1_HUMAN with the residue 301 substituted with Phosphothreonine" [UniProtKB:Q86U86] xref: UniProtKB:Q86U86 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001938 ! PB1_HUMAN [Term] id: CCO:B0013428 name: PB1_HUMAN-Phosphoserine636 def: "Protein PB1_HUMAN with the residue 636 substituted with Phosphoserine" [UniProtKB:Q86U86] xref: UniProtKB:Q86U86 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001938 ! PB1_HUMAN [Term] id: CCO:B0013429 name: PB1_HUMAN-Phosphoserine948 def: "Protein PB1_HUMAN with the residue 948 substituted with Phosphoserine" [UniProtKB:Q86U86] xref: UniProtKB:Q86U86 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001938 ! PB1_HUMAN [Term] id: CCO:B0013430 name: PB1_HUMAN-Phosphoserine1453 def: "Protein PB1_HUMAN with the residue 1453 substituted with Phosphoserine" [UniProtKB:Q86U86] xref: UniProtKB:Q86U86 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001938 ! PB1_HUMAN [Term] id: CCO:B0013431 name: PBX2_HUMAN-Phosphoserine105 def: "Protein PBX2_HUMAN with the residue 105 substituted with Phosphoserine" [UniProtKB:P40425] xref: UniProtKB:P40425 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005895 ! PBX2_HUMAN [Term] id: CCO:B0013433 name: PCNP_HUMAN-Phosphothreonine66 def: "Protein PCNP_HUMAN with the residue 66 substituted with Phosphothreonine" [UniProtKB:Q8WW12] xref: UniProtKB:Q8WW12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002005 ! PCNP_HUMAN [Term] id: CCO:B0013434 name: PCNP_HUMAN-Phosphoserine69 def: "Protein PCNP_HUMAN with the residue 69 substituted with Phosphoserine" [UniProtKB:Q8WW12] xref: UniProtKB:Q8WW12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002005 ! PCNP_HUMAN [Term] id: CCO:B0013435 name: PCNP_HUMAN-Phosphoserine77 def: "Protein PCNP_HUMAN with the residue 77 substituted with Phosphoserine" [UniProtKB:Q8WW12] xref: UniProtKB:Q8WW12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002005 ! PCNP_HUMAN [Term] id: CCO:B0013436 name: PCNP_HUMAN-Phosphothreonine139 def: "Protein PCNP_HUMAN with the residue 139 substituted with Phosphothreonine" [UniProtKB:Q8WW12] xref: UniProtKB:Q8WW12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002005 ! PCNP_HUMAN [Term] id: CCO:B0013437 name: PCNP_HUMAN-Phosphoserine142 def: "Protein PCNP_HUMAN with the residue 142 substituted with Phosphoserine" [UniProtKB:Q8WW12] xref: UniProtKB:Q8WW12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002005 ! PCNP_HUMAN [Term] id: CCO:B0013438 name: PCNP_HUMAN-Phosphoserine147 def: "Protein PCNP_HUMAN with the residue 147 substituted with Phosphoserine" [UniProtKB:Q8WW12] xref: UniProtKB:Q8WW12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002005 ! PCNP_HUMAN [Term] id: CCO:B0013439 name: PCNT_HUMAN-Phosphoserine1703 def: "Protein PCNT_HUMAN with the residue 1703 substituted with Phosphoserine" [UniProtKB:O95613] xref: UniProtKB:O95613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006078 ! PCNT_HUMAN [Term] id: CCO:B0013446 name: PCTK3_HUMAN-Phosphoserine12 def: "Protein PCTK3_HUMAN with the residue 12 substituted with Phosphoserine" [UniProtKB:Q07002] xref: UniProtKB:Q07002 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005295 ! PCTK3_HUMAN [Term] id: CCO:B0013447 name: PCTK3_HUMAN-Phosphoserine87 def: "Protein PCTK3_HUMAN with the residue 87 substituted with Phosphoserine" [UniProtKB:Q07002] xref: UniProtKB:Q07002 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005295 ! PCTK3_HUMAN [Term] id: CCO:B0013448 name: PCTK3_HUMAN-Phosphoserine130 def: "Protein PCTK3_HUMAN with the residue 130 substituted with Phosphoserine" [UniProtKB:Q07002] xref: UniProtKB:Q07002 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005295 ! PCTK3_HUMAN [Term] id: CCO:B0013449 name: PCTK3_HUMAN-Phosphoserine132 def: "Protein PCTK3_HUMAN with the residue 132 substituted with Phosphoserine" [UniProtKB:Q07002] comment: By similarity xref: UniProtKB:Q07002 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005295 ! PCTK3_HUMAN [Term] id: CCO:B0013450 name: PDCD4_HUMAN-Phosphoserine76 def: "Protein PDCD4_HUMAN with the residue 76 substituted with Phosphoserine" [UniProtKB:Q53EL6] xref: UniProtKB:Q53EL6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001836 ! PDCD4_HUMAN [Term] id: CCO:B0013451 name: PDCD4_HUMAN-Phosphothreonine93 def: "Protein PDCD4_HUMAN with the residue 93 substituted with Phosphothreonine" [UniProtKB:Q53EL6] xref: UniProtKB:Q53EL6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001836 ! PDCD4_HUMAN [Term] id: CCO:B0013452 name: PDCD4_HUMAN-Phosphotyrosine152 def: "Protein PDCD4_HUMAN with the residue 152 substituted with Phosphotyrosine" [UniProtKB:Q53EL6] xref: UniProtKB:Q53EL6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001836 ! PDCD4_HUMAN [Term] id: CCO:B0013453 name: PDCD4_HUMAN-Phosphoserine457 def: "Protein PDCD4_HUMAN with the residue 457 substituted with Phosphoserine" [UniProtKB:Q53EL6] xref: UniProtKB:Q53EL6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000308 ! RNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0001836 ! PDCD4_HUMAN [Term] id: CCO:B0013454 name: PDCD5_HUMAN-Phosphoserine119 def: "Protein PDCD5_HUMAN with the residue 119 substituted with Phosphoserine" [UniProtKB:O14737] xref: UniProtKB:O14737 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006152 ! PDCD5_HUMAN [Term] id: CCO:B0013464 name: PDLI5_HUMAN-N-acetylserine2 def: "Protein PDLI5_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:Q96HC4] xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013465 name: PDLI5_HUMAN-Phosphothreonine110 def: "Protein PDLI5_HUMAN with the residue 110 substituted with Phosphothreonine" [UniProtKB:Q96HC4] xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013466 name: PDLI5_HUMAN-Phosphoserine111 def: "Protein PDLI5_HUMAN with the residue 111 substituted with Phosphoserine" [UniProtKB:Q96HC4] xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013467 name: PDLI5_HUMAN-Phosphoserine134 def: "Protein PDLI5_HUMAN with the residue 134 substituted with Phosphoserine" [UniProtKB:Q96HC4] xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013468 name: PDLI5_HUMAN-Phosphoserine136 def: "Protein PDLI5_HUMAN with the residue 136 substituted with Phosphoserine" [UniProtKB:Q96HC4] xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013469 name: PDLI5_HUMAN-Phosphoserine137 def: "Protein PDLI5_HUMAN with the residue 137 substituted with Phosphoserine" [UniProtKB:Q96HC4] xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013470 name: PDLI5_HUMAN-Phosphoserine228 def: "Protein PDLI5_HUMAN with the residue 228 substituted with Phosphoserine" [UniProtKB:Q96HC4] comment: By similarity xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013471 name: PDLI5_HUMAN-Phosphotyrosine251 def: "Protein PDLI5_HUMAN with the residue 251 substituted with Phosphotyrosine" [UniProtKB:Q96HC4] xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013472 name: PDLI5_HUMAN-Phosphoserine309 def: "Protein PDLI5_HUMAN with the residue 309 substituted with Phosphoserine" [UniProtKB:Q96HC4] xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013473 name: PDLI5_HUMAN-Phosphoserine313 def: "Protein PDLI5_HUMAN with the residue 313 substituted with Phosphoserine" [UniProtKB:Q96HC4] xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013474 name: PDLI5_HUMAN-Phosphoserine335 def: "Protein PDLI5_HUMAN with the residue 335 substituted with Phosphoserine" [UniProtKB:Q96HC4] comment: By similarity xref: UniProtKB:Q96HC4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:B0013475 name: PDLI7_HUMAN-Phosphothreonine251 def: "Protein PDLI7_HUMAN with the residue 251 substituted with Phosphothreonine" [UniProtKB:Q9NR12] xref: UniProtKB:Q9NR12 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005224 ! PDLI7_HUMAN [Term] id: CCO:B0013476 name: PDPK1_HUMAN-Phosphotyrosine9 def: "Protein PDPK1_HUMAN with the residue 9 substituted with Phosphotyrosine" [UniProtKB:O15530] xref: UniProtKB:O15530 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:B0013477 name: PDPK1_HUMAN-Phosphoserine25 def: "Protein PDPK1_HUMAN with the residue 25 substituted with Phosphoserine" [UniProtKB:O15530] xref: UniProtKB:O15530 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:B0013478 name: PDPK1_HUMAN-Phosphoserine241 def: "Protein PDPK1_HUMAN with the residue 241 substituted with Phosphoserine" [UniProtKB:O15530] comment: by autocatalysis; xref: UniProtKB:O15530 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:B0013479 name: PDPK1_HUMAN-Phosphothreonine245 def: "Protein PDPK1_HUMAN with the residue 245 substituted with Phosphothreonine" [UniProtKB:O15530] xref: UniProtKB:O15530 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:B0013480 name: PDPK1_HUMAN-Phosphotyrosine373 def: "Protein PDPK1_HUMAN with the residue 373 substituted with Phosphotyrosine" [UniProtKB:O15530] xref: UniProtKB:O15530 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:B0013481 name: PDPK1_HUMAN-Phosphotyrosine376 def: "Protein PDPK1_HUMAN with the residue 376 substituted with Phosphotyrosine" [UniProtKB:O15530] xref: UniProtKB:O15530 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:B0013482 name: PDPK1_HUMAN-Phosphoserine393 def: "Protein PDPK1_HUMAN with the residue 393 substituted with Phosphoserine" [UniProtKB:O15530] xref: UniProtKB:O15530 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:B0013483 name: PDPK1_HUMAN-Phosphoserine396 def: "Protein PDPK1_HUMAN with the residue 396 substituted with Phosphoserine" [UniProtKB:O15530] xref: UniProtKB:O15530 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:B0013484 name: PDPK1_HUMAN-Phosphoserine410 def: "Protein PDPK1_HUMAN with the residue 410 substituted with Phosphoserine" [UniProtKB:O15530] xref: UniProtKB:O15530 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:B0013485 name: PDS5A_HUMAN-Phosphothreonine1208 def: "Protein PDS5A_HUMAN with the residue 1208 substituted with Phosphothreonine" [UniProtKB:Q29RF7] xref: UniProtKB:Q29RF7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001829 ! PDS5A_HUMAN [Term] id: CCO:B0013486 name: PDS5A_HUMAN-Phosphoserine1305 def: "Protein PDS5A_HUMAN with the residue 1305 substituted with Phosphoserine" [UniProtKB:Q29RF7] xref: UniProtKB:Q29RF7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001829 ! PDS5A_HUMAN [Term] id: CCO:B0013487 name: PEX19_HUMAN-Phosphoserine35 def: "Protein PEX19_HUMAN with the residue 35 substituted with Phosphoserine" [UniProtKB:P40855] xref: UniProtKB:P40855 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005820 ! PEX19_HUMAN [Term] id: CCO:B0013488 name: PEX19_HUMAN-Phosphoserine54 def: "Protein PEX19_HUMAN with the residue 54 substituted with Phosphoserine" [UniProtKB:P40855] xref: UniProtKB:P40855 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005820 ! PEX19_HUMAN [Term] id: CCO:B0013489 name: PEX19_HUMAN-Phosphoserine146 def: "Protein PEX19_HUMAN with the residue 146 substituted with Phosphoserine" [UniProtKB:P40855] xref: UniProtKB:P40855 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005820 ! PEX19_HUMAN [Term] id: CCO:B0013490 name: PEX19_HUMAN-Phosphoserine147 def: "Protein PEX19_HUMAN with the residue 147 substituted with Phosphoserine" [UniProtKB:P40855] xref: UniProtKB:P40855 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005820 ! PEX19_HUMAN [Term] id: CCO:B0013491 name: PEX19_HUMAN-Phosphoserine149 def: "Protein PEX19_HUMAN with the residue 149 substituted with Phosphoserine" [UniProtKB:P40855] xref: UniProtKB:P40855 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005820 ! PEX19_HUMAN [Term] id: CCO:B0013492 name: PEX19_HUMAN-Phosphoserine177 def: "Protein PEX19_HUMAN with the residue 177 substituted with Phosphoserine" [UniProtKB:P40855] xref: UniProtKB:P40855 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005820 ! PEX19_HUMAN [Term] id: CCO:B0013493 name: PEX19_HUMAN-Phosphoserine184 def: "Protein PEX19_HUMAN with the residue 184 substituted with Phosphoserine" [UniProtKB:P40855] xref: UniProtKB:P40855 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005820 ! PEX19_HUMAN [Term] id: CCO:B0013494 name: PGAM1_HUMAN-N-acetylalanine2 def: "Protein PGAM1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P18669] xref: UniProtKB:P18669 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006323 ! PGAM1_HUMAN [Term] id: CCO:B0013495 name: PGAM1_HUMAN-Phosphoserine14 def: "Protein PGAM1_HUMAN with the residue 14 substituted with Phosphoserine" [UniProtKB:P18669] comment: By similarity xref: UniProtKB:P18669 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006323 ! PGAM1_HUMAN [Term] id: CCO:B0013496 name: PGAM1_HUMAN-Phosphotyrosine26 def: "Protein PGAM1_HUMAN with the residue 26 substituted with Phosphotyrosine" [UniProtKB:P18669] xref: UniProtKB:P18669 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006323 ! PGAM1_HUMAN [Term] id: CCO:B0013497 name: PGAM1_HUMAN-Phosphoserine118 def: "Protein PGAM1_HUMAN with the residue 118 substituted with Phosphoserine" [UniProtKB:P18669] comment: By similarity xref: UniProtKB:P18669 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006323 ! PGAM1_HUMAN [Term] id: CCO:B0013500 name: PHB_HUMAN-Phosphoserine252 def: "Protein PHB_HUMAN with the residue 252 substituted with Phosphoserine" [UniProtKB:P35232] xref: UniProtKB:P35232 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001591 ! PHB_HUMAN [Term] id: CCO:B0013501 name: PHB_HUMAN-Phosphoserine254 def: "Protein PHB_HUMAN with the residue 254 substituted with Phosphoserine" [UniProtKB:P35232] xref: UniProtKB:P35232 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001591 ! PHB_HUMAN [Term] id: CCO:B0013502 name: PHC2_HUMAN-Phosphoserine701 def: "Protein PHC2_HUMAN with the residue 701 substituted with Phosphoserine" [UniProtKB:Q8IXK0] xref: UniProtKB:Q8IXK0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005978 ! PHC2_HUMAN [Term] id: CCO:B0013503 name: PHC2_HUMAN-Phosphoserine704 def: "Protein PHC2_HUMAN with the residue 704 substituted with Phosphoserine" [UniProtKB:Q8IXK0] xref: UniProtKB:Q8IXK0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005978 ! PHC2_HUMAN [Term] id: CCO:B0013504 name: PHC2_HUMAN-Phosphoserine733 def: "Protein PHC2_HUMAN with the residue 733 substituted with Phosphoserine" [UniProtKB:Q8IXK0] xref: UniProtKB:Q8IXK0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005978 ! PHC2_HUMAN [Term] id: CCO:B0013505 name: PHC2_HUMAN-Phosphoserine745 def: "Protein PHC2_HUMAN with the residue 745 substituted with Phosphoserine" [UniProtKB:Q8IXK0] xref: UniProtKB:Q8IXK0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005978 ! PHC2_HUMAN [Term] id: CCO:B0013506 name: PIAS1_HUMAN-Phosphoserine466 def: "Protein PIAS1_HUMAN with the residue 466 substituted with Phosphoserine" [UniProtKB:O75925] xref: UniProtKB:O75925 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005579 ! PIAS1_HUMAN [Term] id: CCO:B0013507 name: PIAS1_HUMAN-Phosphoserine467 def: "Protein PIAS1_HUMAN with the residue 467 substituted with Phosphoserine" [UniProtKB:O75925] xref: UniProtKB:O75925 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005579 ! PIAS1_HUMAN [Term] id: CCO:B0013508 name: PIAS1_HUMAN-Phosphoserine468 def: "Protein PIAS1_HUMAN with the residue 468 substituted with Phosphoserine" [UniProtKB:O75925] xref: UniProtKB:O75925 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005579 ! PIAS1_HUMAN [Term] id: CCO:B0013509 name: PIAS1_HUMAN-Phosphoserine483 def: "Protein PIAS1_HUMAN with the residue 483 substituted with Phosphoserine" [UniProtKB:O75925] comment: By similarity xref: UniProtKB:O75925 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005579 ! PIAS1_HUMAN [Term] id: CCO:B0013510 name: PIAS1_HUMAN-Phosphoserine485 def: "Protein PIAS1_HUMAN with the residue 485 substituted with Phosphoserine" [UniProtKB:O75925] comment: By similarity xref: UniProtKB:O75925 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005579 ! PIAS1_HUMAN [Term] id: CCO:B0013511 name: PIAS1_HUMAN-Phosphothreonine487 def: "Protein PIAS1_HUMAN with the residue 487 substituted with Phosphothreonine" [UniProtKB:O75925] comment: By similarity xref: UniProtKB:O75925 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005579 ! PIAS1_HUMAN [Term] id: CCO:B0013512 name: PIM2_HUMAN-Phosphothreonine195 def: "Protein PIM2_HUMAN with the residue 195 substituted with Phosphothreonine" [UniProtKB:Q9P1W9] xref: UniProtKB:Q9P1W9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002185 ! PIM2_HUMAN [Term] id: CCO:B0013513 name: PIM2_HUMAN-Phosphoserine204 def: "Protein PIM2_HUMAN with the residue 204 substituted with Phosphoserine" [UniProtKB:Q9P1W9] xref: UniProtKB:Q9P1W9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002185 ! PIM2_HUMAN [Term] id: CCO:B0013514 name: PIN1_HUMAN-Phosphoserine108 def: "Protein PIN1_HUMAN with the residue 108 substituted with Phosphoserine" [UniProtKB:Q13526] xref: UniProtKB:Q13526 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001755 ! PIN1_HUMAN [Term] id: CCO:B0013515 name: PININ_HUMAN-N-acetylalanine2 def: "Protein PININ_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013516 name: PININ_HUMAN-Phosphoserine66 def: "Protein PININ_HUMAN with the residue 66 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013517 name: PININ_HUMAN-Phosphoserine96 def: "Protein PININ_HUMAN with the residue 96 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013518 name: PININ_HUMAN-Phosphoserine100 def: "Protein PININ_HUMAN with the residue 100 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013519 name: PININ_HUMAN-Phosphoserine114 def: "Protein PININ_HUMAN with the residue 114 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013520 name: PININ_HUMAN-Phosphoserine347 def: "Protein PININ_HUMAN with the residue 347 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013521 name: PININ_HUMAN-Phosphoserine381 def: "Protein PININ_HUMAN with the residue 381 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013522 name: PININ_HUMAN-Phosphoserine441 def: "Protein PININ_HUMAN with the residue 441 substituted with Phosphoserine" [UniProtKB:Q9H307] comment: By similarity xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013523 name: PININ_HUMAN-Phosphoserine443 def: "Protein PININ_HUMAN with the residue 443 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013524 name: PININ_HUMAN-Phosphoserine649 def: "Protein PININ_HUMAN with the residue 649 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013525 name: PININ_HUMAN-Phosphoserine658 def: "Protein PININ_HUMAN with the residue 658 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013526 name: PININ_HUMAN-Phosphoserine663 def: "Protein PININ_HUMAN with the residue 663 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013527 name: PININ_HUMAN-Phosphoserine666 def: "Protein PININ_HUMAN with the residue 666 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013528 name: PININ_HUMAN-Phosphoserine667 def: "Protein PININ_HUMAN with the residue 667 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013529 name: PININ_HUMAN-Phosphoserine671 def: "Protein PININ_HUMAN with the residue 671 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013530 name: PININ_HUMAN-Phosphoserine672 def: "Protein PININ_HUMAN with the residue 672 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013531 name: PININ_HUMAN-Phosphoserine690 def: "Protein PININ_HUMAN with the residue 690 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013532 name: PININ_HUMAN-Phosphoserine692 def: "Protein PININ_HUMAN with the residue 692 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013533 name: PININ_HUMAN-Phosphoserine695 def: "Protein PININ_HUMAN with the residue 695 substituted with Phosphoserine" [UniProtKB:Q9H307] xref: UniProtKB:Q9H307 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002131 ! PININ_HUMAN [Term] id: CCO:B0013534 name: PKCB1_HUMAN-Phosphoserine486 def: "Protein PKCB1_HUMAN with the residue 486 substituted with Phosphoserine" [UniProtKB:Q9ULU4] xref: UniProtKB:Q9ULU4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005935 ! PKCB1_HUMAN [Term] id: CCO:B0013535 name: PKCB1_HUMAN-Phosphoserine490 def: "Protein PKCB1_HUMAN with the residue 490 substituted with Phosphoserine" [UniProtKB:Q9ULU4] xref: UniProtKB:Q9ULU4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005935 ! PKCB1_HUMAN [Term] id: CCO:B0013536 name: PKCB1_HUMAN-Phosphoserine547 def: "Protein PKCB1_HUMAN with the residue 547 substituted with Phosphoserine" [UniProtKB:Q9ULU4] xref: UniProtKB:Q9ULU4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005935 ! PKCB1_HUMAN [Term] id: CCO:B0013537 name: PKCB1_HUMAN-Phosphoserine652 def: "Protein PKCB1_HUMAN with the residue 652 substituted with Phosphoserine" [UniProtKB:Q9ULU4] xref: UniProtKB:Q9ULU4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005935 ! PKCB1_HUMAN [Term] id: CCO:B0013538 name: PKCB1_HUMAN-Phosphoserine668 def: "Protein PKCB1_HUMAN with the residue 668 substituted with Phosphoserine" [UniProtKB:Q9ULU4] xref: UniProtKB:Q9ULU4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005935 ! PKCB1_HUMAN [Term] id: CCO:B0013539 name: PKCB1_HUMAN-Phosphoserine1086 def: "Protein PKCB1_HUMAN with the residue 1086 substituted with Phosphoserine" [UniProtKB:Q9ULU4] xref: UniProtKB:Q9ULU4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005935 ! PKCB1_HUMAN [Term] id: CCO:B0013547 name: PKN1_HUMAN-Phosphoserine376 def: "Protein PKN1_HUMAN with the residue 376 substituted with Phosphoserine" [UniProtKB:Q16512] xref: UniProtKB:Q16512 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006068 ! PKN1_HUMAN [Term] id: CCO:B0013548 name: PKN1_HUMAN-Phosphoserine562 def: "Protein PKN1_HUMAN with the residue 562 substituted with Phosphoserine" [UniProtKB:Q16512] xref: UniProtKB:Q16512 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006068 ! PKN1_HUMAN [Term] id: CCO:B0013549 name: PKN1_HUMAN-Phosphothreonine774 def: "Protein PKN1_HUMAN with the residue 774 substituted with Phosphothreonine" [UniProtKB:Q16512] comment: Probable xref: UniProtKB:Q16512 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006068 ! PKN1_HUMAN [Term] id: CCO:B0013550 name: PKN1_HUMAN-Phosphoserine916 def: "Protein PKN1_HUMAN with the residue 916 substituted with Phosphoserine" [UniProtKB:Q16512] xref: UniProtKB:Q16512 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006068 ! PKN1_HUMAN [Term] id: CCO:B0013551 name: PKP2_HUMAN-Phosphoserine132 def: "Protein PKP2_HUMAN with the residue 132 substituted with Phosphoserine" [UniProtKB:Q99959] xref: UniProtKB:Q99959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005826 ! PKP2_HUMAN [Term] id: CCO:B0013552 name: PKP2_HUMAN-Phosphoserine169 def: "Protein PKP2_HUMAN with the residue 169 substituted with Phosphoserine" [UniProtKB:Q99959] xref: UniProtKB:Q99959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005826 ! PKP2_HUMAN [Term] id: CCO:B0013564 name: PLCG1_HUMAN-Phosphotyrosine771 def: "Protein PLCG1_HUMAN with the residue 771 substituted with Phosphotyrosine" [UniProtKB:P19174] xref: UniProtKB:P19174 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005610 ! PLCG1_HUMAN [Term] id: CCO:B0013565 name: PLCG1_HUMAN-Phosphotyrosine775 def: "Protein PLCG1_HUMAN with the residue 775 substituted with Phosphotyrosine" [UniProtKB:P19174] xref: UniProtKB:P19174 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005610 ! PLCG1_HUMAN [Term] id: CCO:B0013566 name: PLCG1_HUMAN-Phosphotyrosine783 def: "Protein PLCG1_HUMAN with the residue 783 substituted with Phosphotyrosine" [UniProtKB:P19174] xref: UniProtKB:P19174 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005610 ! PLCG1_HUMAN [Term] id: CCO:B0013567 name: PLCG1_HUMAN-Phosphotyrosine1253 def: "Protein PLCG1_HUMAN with the residue 1253 substituted with Phosphotyrosine" [UniProtKB:P19174] xref: UniProtKB:P19174 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005610 ! PLCG1_HUMAN [Term] id: CCO:B0013568 name: PLK1_HUMAN-Phosphoserine137 def: "Protein PLK1_HUMAN with the residue 137 substituted with Phosphoserine" [UniProtKB:P53350] comment: Probable xref: UniProtKB:P53350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:B0013569 name: PLK1_HUMAN-Phosphothreonine210 def: "Protein PLK1_HUMAN with the residue 210 substituted with Phosphothreonine" [UniProtKB:P53350] xref: UniProtKB:P53350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:B0013570 name: PLK1_HUMAN-Phosphoserine269 def: "Protein PLK1_HUMAN with the residue 269 substituted with Phosphoserine" [UniProtKB:P53350] comment: by autocatalysis; By similarity xref: UniProtKB:P53350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:B0013571 name: PLK1_HUMAN-Phosphoserine335 def: "Protein PLK1_HUMAN with the residue 335 substituted with Phosphoserine" [UniProtKB:P53350] xref: UniProtKB:P53350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:B0013572 name: PML_HUMAN-Phosphoserine8 def: "Protein PML_HUMAN with the residue 8 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013573 name: PML_HUMAN-Phosphoserine403 def: "Protein PML_HUMAN with the residue 403 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013574 name: PML_HUMAN-Phosphoserine504 def: "Protein PML_HUMAN with the residue 504 substituted with Phosphoserine" [UniProtKB:P29590] comment: By similarity xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013575 name: PML_HUMAN-Phosphoserine505 def: "Protein PML_HUMAN with the residue 505 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013576 name: PML_HUMAN-Phosphoserine512 def: "Protein PML_HUMAN with the residue 512 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013577 name: PML_HUMAN-Phosphoserine518 def: "Protein PML_HUMAN with the residue 518 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013578 name: PML_HUMAN-Phosphoserine527 def: "Protein PML_HUMAN with the residue 527 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013579 name: PML_HUMAN-Phosphoserine530 def: "Protein PML_HUMAN with the residue 530 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013580 name: PML_HUMAN-Phosphoserine535 def: "Protein PML_HUMAN with the residue 535 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013581 name: PML_HUMAN-Phosphoserine560 def: "Protein PML_HUMAN with the residue 560 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013582 name: PML_HUMAN-Phosphoserine561 def: "Protein PML_HUMAN with the residue 561 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013583 name: PML_HUMAN-Phosphoserine562 def: "Protein PML_HUMAN with the residue 562 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013584 name: PML_HUMAN-Phosphoserine565 def: "Protein PML_HUMAN with the residue 565 substituted with Phosphoserine" [UniProtKB:P29590] xref: UniProtKB:P29590 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001570 ! PML_HUMAN [Term] id: CCO:B0013585 name: PMS2_HUMAN-Phosphotyrosine181 def: "Protein PMS2_HUMAN with the residue 181 substituted with Phosphotyrosine" [UniProtKB:P54278] comment: By similarity xref: UniProtKB:P54278 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001669 ! PMS2_HUMAN [Term] id: CCO:B0013586 name: PMS2_HUMAN-Phosphoserine403 def: "Protein PMS2_HUMAN with the residue 403 substituted with Phosphoserine" [UniProtKB:P54278] xref: UniProtKB:P54278 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001669 ! PMS2_HUMAN [Term] id: CCO:B0013587 name: PMS2_HUMAN-Phosphothreonine573 def: "Protein PMS2_HUMAN with the residue 573 substituted with Phosphothreonine" [UniProtKB:P54278] xref: UniProtKB:P54278 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001669 ! PMS2_HUMAN [Term] id: CCO:B0013588 name: PMYT1_HUMAN-Phosphoserine94 def: "Protein PMYT1_HUMAN with the residue 94 substituted with Phosphoserine" [UniProtKB:Q99640] xref: UniProtKB:Q99640 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002078 ! PMYT1_HUMAN [Term] id: CCO:B0013589 name: PMYT1_HUMAN-Phosphoserine143 def: "Protein PMYT1_HUMAN with the residue 143 substituted with Phosphoserine" [UniProtKB:Q99640] xref: UniProtKB:Q99640 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002078 ! PMYT1_HUMAN [Term] id: CCO:B0013590 name: PMYT1_HUMAN-Phosphoserine426 def: "Protein PMYT1_HUMAN with the residue 426 substituted with Phosphoserine" [UniProtKB:Q99640] comment: by PLK1; xref: UniProtKB:Q99640 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002078 ! PMYT1_HUMAN [Term] id: CCO:B0013591 name: PMYT1_HUMAN-Phosphothreonine495 def: "Protein PMYT1_HUMAN with the residue 495 substituted with Phosphothreonine" [UniProtKB:Q99640] comment: by PLK1; xref: UniProtKB:Q99640 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002078 ! PMYT1_HUMAN [Term] id: CCO:B0013592 name: PNPH_HUMAN-N-acetylmethionine1 def: "Protein PNPH_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P00491] xref: UniProtKB:P00491 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006097 ! PNPH_HUMAN [Term] id: CCO:B0013593 name: PO2F1_HUMAN-Phosphoserine448 def: "Protein PO2F1_HUMAN with the residue 448 substituted with Phosphoserine" [UniProtKB:P14859] xref: UniProtKB:P14859 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006069 ! PO2F1_HUMAN [Term] id: CCO:B0013594 name: PP1B_HUMAN-N-acetylalanine2 def: "Protein PP1B_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P62140] xref: UniProtKB:P62140 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001689 ! PP1B_HUMAN [Term] id: CCO:B0013595 name: PP1B_HUMAN-Phosphoserine41 def: "Protein PP1B_HUMAN with the residue 41 substituted with Phosphoserine" [UniProtKB:P62140] xref: UniProtKB:P62140 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001689 ! PP1B_HUMAN [Term] id: CCO:B0013596 name: PP1B_HUMAN-Phosphoserine47 def: "Protein PP1B_HUMAN with the residue 47 substituted with Phosphoserine" [UniProtKB:P62140] xref: UniProtKB:P62140 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001689 ! PP1B_HUMAN [Term] id: CCO:B0013597 name: PP2AA_HUMAN-Phosphotyrosine307 def: "Protein PP2AA_HUMAN with the residue 307 substituted with Phosphotyrosine" [UniProtKB:P67775] xref: UniProtKB:P67775 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001697 ! PP2AA_HUMAN [Term] id: CCO:B0013598 name: PP2AA_HUMAN-Leucine methyl ester309 def: "Protein PP2AA_HUMAN with the residue 309 substituted with Leucine methyl ester" [UniProtKB:P67775] xref: UniProtKB:P67775 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001697 ! PP2AA_HUMAN [Term] id: CCO:B0013599 name: PPARG_HUMAN-Phosphoserine112 def: "Protein PPARG_HUMAN with the residue 112 substituted with Phosphoserine" [UniProtKB:P37231] comment: by MAPK; By similarity xref: UniProtKB:P37231 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005616 ! PPARG_HUMAN [Term] id: CCO:B0013600 name: PPIA_HUMAN-N-acetylvaline2 def: "Protein PPIA_HUMAN with the residue 2 substituted with N-acetylvaline" [UniProtKB:P62937] comment: partial; xref: UniProtKB:P62937 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006072 ! PPIA_HUMAN [Term] id: CCO:B0013601 name: PPIA_HUMAN-Phosphoserine21 def: "Protein PPIA_HUMAN with the residue 21 substituted with Phosphoserine" [UniProtKB:P62937] comment: By similarity xref: UniProtKB:P62937 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006072 ! PPIA_HUMAN [Term] id: CCO:B0013602 name: PPIA_HUMAN-N6-acetyllysine125 def: "Protein PPIA_HUMAN with the residue 125 substituted with N6-acetyllysine" [UniProtKB:P62937] xref: UniProtKB:P62937 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006072 ! PPIA_HUMAN [Term] id: CCO:B0013603 name: PPIA_HUMAN-Phosphothreonine157 def: "Protein PPIA_HUMAN with the residue 157 substituted with Phosphothreonine" [UniProtKB:P62937] xref: UniProtKB:P62937 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006072 ! PPIA_HUMAN [Term] id: CCO:B0013604 name: PPM1A_HUMAN-Phosphoserine377 def: "Protein PPM1A_HUMAN with the residue 377 substituted with Phosphoserine" [UniProtKB:P35813] comment: By similarity xref: UniProtKB:P35813 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005649 ! PPM1A_HUMAN [Term] id: CCO:B0013605 name: PPM1G_HUMAN-Phosphoserine183 def: "Protein PPM1G_HUMAN with the residue 183 substituted with Phosphoserine" [UniProtKB:O15355] xref: UniProtKB:O15355 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001375 ! PPM1G_HUMAN [Term] id: CCO:B0013606 name: PPM1G_HUMAN-Phosphoserine527 def: "Protein PPM1G_HUMAN with the residue 527 substituted with Phosphoserine" [UniProtKB:O15355] xref: UniProtKB:O15355 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0000343 ! catalytic activity relationship: has_function CCO:F0001086 ! phosphoprotein phosphatase activity relationship: has_function CCO:F0001087 ! protein serine/threonine phosphatase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000541 ! protein serine/threonine phosphatase complex relationship: transformation_of CCO:B0001375 ! PPM1G_HUMAN [Term] id: CCO:B0013607 name: PR285_HUMAN-Phosphoserine338 def: "Protein PR285_HUMAN with the residue 338 substituted with Phosphoserine" [UniProtKB:Q9BYK8] xref: UniProtKB:Q9BYK8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006035 ! PR285_HUMAN [Term] id: CCO:B0013608 name: PRC1_HUMAN-Phosphoserine195 def: "Protein PRC1_HUMAN with the residue 195 substituted with Phosphoserine" [UniProtKB:O43663] xref: UniProtKB:O43663 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001394 ! PRC1_HUMAN [Term] id: CCO:B0013609 name: PRC1_HUMAN-Phosphothreonine470 def: "Protein PRC1_HUMAN with the residue 470 substituted with Phosphothreonine" [UniProtKB:O43663] comment: by CDK2; in vitro; xref: UniProtKB:O43663 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001394 ! PRC1_HUMAN [Term] id: CCO:B0013610 name: PRC1_HUMAN-Phosphothreonine481 def: "Protein PRC1_HUMAN with the residue 481 substituted with Phosphothreonine" [UniProtKB:O43663] xref: UniProtKB:O43663 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001394 ! PRC1_HUMAN [Term] id: CCO:B0013611 name: PRC1_HUMAN-Phosphoserine592 def: "Protein PRC1_HUMAN with the residue 592 substituted with Phosphoserine" [UniProtKB:O43663] xref: UniProtKB:O43663 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001394 ! PRC1_HUMAN [Term] id: CCO:B0013612 name: PRI2_HUMAN-Phosphotyrosine381 def: "Protein PRI2_HUMAN with the residue 381 substituted with Phosphotyrosine" [UniProtKB:P49643] xref: UniProtKB:P49643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005508 ! PRI2_HUMAN [Term] id: CCO:B0013613 name: PROF1_HUMAN-N-acetylalanine2 def: "Protein PROF1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P07737] xref: UniProtKB:P07737 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006154 ! PROF1_HUMAN [Term] id: CCO:B0013614 name: PROF1_HUMAN-N6-acetyllysine105 def: "Protein PROF1_HUMAN with the residue 105 substituted with N6-acetyllysine" [UniProtKB:P07737] xref: UniProtKB:P07737 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006154 ! PROF1_HUMAN [Term] id: CCO:B0013615 name: PROF1_HUMAN-Phosphotyrosine129 def: "Protein PROF1_HUMAN with the residue 129 substituted with Phosphotyrosine" [UniProtKB:P07737] xref: UniProtKB:P07737 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006154 ! PROF1_HUMAN [Term] id: CCO:B0013616 name: PROF2_HUMAN-N-acetylalanine2 def: "Protein PROF2_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P35080] comment: By similarity xref: UniProtKB:P35080 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006155 ! PROF2_HUMAN [Term] id: CCO:B0013617 name: PRS4_HUMAN-Phosphotyrosine439 def: "Protein PRS4_HUMAN with the residue 439 substituted with Phosphotyrosine" [UniProtKB:P62191] xref: UniProtKB:P62191 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0003445 ! ATPase activity relationship: has_function CCO:F0003574 ! nucleoside-triphosphatase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: transformation_of CCO:B0005314 ! PRS4_HUMAN [Term] id: CCO:B0013618 name: PSA1_HUMAN-N-acetylmethionine1 def: "Protein PSA1_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P25786] xref: UniProtKB:P25786 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000308 ! RNA binding relationship: has_function CCO:F0000644 ! endopeptidase activity relationship: has_function CCO:F0000721 ! threonine endopeptidase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001783 ! peptidase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0000410 ! polysome relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: located_in CCO:C0002080 ! proteasome core complex relationship: transformation_of CCO:B0005233 ! PSA1_HUMAN [Term] id: CCO:B0013619 name: PSA3_HUMAN-N-acetylserine2 def: "Protein PSA3_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P25788] xref: UniProtKB:P25788 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005991 ! PSA3_HUMAN [Term] id: CCO:B0013620 name: PSA3_HUMAN-Phosphotyrosine161 def: "Protein PSA3_HUMAN with the residue 161 substituted with Phosphotyrosine" [UniProtKB:P25788] xref: UniProtKB:P25788 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005991 ! PSA3_HUMAN [Term] id: CCO:B0013621 name: PSA3_HUMAN-Phosphoserine243 def: "Protein PSA3_HUMAN with the residue 243 substituted with Phosphoserine" [UniProtKB:P25788] xref: UniProtKB:P25788 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005991 ! PSA3_HUMAN [Term] id: CCO:B0013622 name: PSA3_HUMAN-Phosphoserine250 def: "Protein PSA3_HUMAN with the residue 250 substituted with Phosphoserine" [UniProtKB:P25788] xref: UniProtKB:P25788 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005991 ! PSA3_HUMAN [Term] id: CCO:B0013623 name: PSD11_HUMAN-N-acetylalanine2 def: "Protein PSD11_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:O00231] xref: UniProtKB:O00231 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006103 ! PSD11_HUMAN [Term] id: CCO:B0013624 name: PSD11_HUMAN-Phosphoserine14 def: "Protein PSD11_HUMAN with the residue 14 substituted with Phosphoserine" [UniProtKB:O00231] xref: UniProtKB:O00231 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006103 ! PSD11_HUMAN [Term] id: CCO:B0013625 name: PSD11_HUMAN-Phosphoserine79 def: "Protein PSD11_HUMAN with the residue 79 substituted with Phosphoserine" [UniProtKB:O00231] xref: UniProtKB:O00231 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006103 ! PSD11_HUMAN [Term] id: CCO:B0013626 name: PSD11_HUMAN-Phosphoserine272 def: "Protein PSD11_HUMAN with the residue 272 substituted with Phosphoserine" [UniProtKB:O00231] xref: UniProtKB:O00231 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006103 ! PSD11_HUMAN [Term] id: CCO:B0013627 name: PSMD1_HUMAN-N-acetylmethionine1 def: "Protein PSMD1_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:Q99460] comment: partial; xref: UniProtKB:Q99460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002066 ! PSMD1_HUMAN [Term] id: CCO:B0013628 name: PSMD1_HUMAN-Phosphotyrosine49 def: "Protein PSMD1_HUMAN with the residue 49 substituted with Phosphotyrosine" [UniProtKB:Q99460] xref: UniProtKB:Q99460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002066 ! PSMD1_HUMAN [Term] id: CCO:B0013629 name: PSMD1_HUMAN-Phosphothreonine273 def: "Protein PSMD1_HUMAN with the residue 273 substituted with Phosphothreonine" [UniProtKB:Q99460] xref: UniProtKB:Q99460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002066 ! PSMD1_HUMAN [Term] id: CCO:B0013630 name: PSMD1_HUMAN-Phosphothreonine311 def: "Protein PSMD1_HUMAN with the residue 311 substituted with Phosphothreonine" [UniProtKB:Q99460] xref: UniProtKB:Q99460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002066 ! PSMD1_HUMAN [Term] id: CCO:B0013631 name: PSMD1_HUMAN-Phosphoserine315 def: "Protein PSMD1_HUMAN with the residue 315 substituted with Phosphoserine" [UniProtKB:Q99460] xref: UniProtKB:Q99460 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002066 ! PSMD1_HUMAN [Term] id: CCO:B0013632 name: PSMD2_HUMAN-N-acetylmethionine1 def: "Protein PSMD2_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:Q13200] xref: UniProtKB:Q13200 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001745 ! PSMD2_HUMAN [Term] id: CCO:B0013633 name: PSMD2_HUMAN-Phosphoserine16 def: "Protein PSMD2_HUMAN with the residue 16 substituted with Phosphoserine" [UniProtKB:Q13200] xref: UniProtKB:Q13200 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001745 ! PSMD2_HUMAN [Term] id: CCO:B0013634 name: PSMD2_HUMAN-Phosphothreonine90 def: "Protein PSMD2_HUMAN with the residue 90 substituted with Phosphothreonine" [UniProtKB:Q13200] xref: UniProtKB:Q13200 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001745 ! PSMD2_HUMAN [Term] id: CCO:B0013635 name: PSMD2_HUMAN-Phosphoserine361 def: "Protein PSMD2_HUMAN with the residue 361 substituted with Phosphoserine" [UniProtKB:Q13200] xref: UniProtKB:Q13200 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001745 ! PSMD2_HUMAN [Term] id: CCO:B0013640 name: PTEN_HUMAN-Phosphothreonine366 def: "Protein PTEN_HUMAN with the residue 366 substituted with Phosphothreonine" [UniProtKB:P60484] xref: UniProtKB:P60484 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001685 ! PTEN_HUMAN [Term] id: CCO:B0013641 name: PTEN_HUMAN-Phosphoserine370 def: "Protein PTEN_HUMAN with the residue 370 substituted with Phosphoserine" [UniProtKB:P60484] comment: by CK2; xref: UniProtKB:P60484 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001685 ! PTEN_HUMAN [Term] id: CCO:B0013642 name: PTEN_HUMAN-Phosphoserine385 def: "Protein PTEN_HUMAN with the residue 385 substituted with Phosphoserine" [UniProtKB:P60484] comment: by CK2; xref: UniProtKB:P60484 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001685 ! PTEN_HUMAN [Term] id: CCO:B0013643 name: PTEN_HUMAN-Phosphothreonine401 def: "Protein PTEN_HUMAN with the residue 401 substituted with Phosphothreonine" [UniProtKB:P60484] xref: UniProtKB:P60484 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001685 ! PTEN_HUMAN [Term] id: CCO:B0013650 name: PTTG1_HUMAN-Phosphoserine165 def: "Protein PTTG1_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:O95997] comment: by CDC2; xref: UniProtKB:O95997 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001224 ! cysteine protease inhibitor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: transformation_of CCO:B0001457 ! PTTG1_HUMAN [Term] id: CCO:B0013651 name: PYGO2_HUMAN-Phosphoserine97 def: "Protein PYGO2_HUMAN with the residue 97 substituted with Phosphoserine" [UniProtKB:Q9BRQ0] xref: UniProtKB:Q9BRQ0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006062 ! PYGO2_HUMAN [Term] id: CCO:B0013652 name: PYGO2_HUMAN-Phosphothreonine302 def: "Protein PYGO2_HUMAN with the residue 302 substituted with Phosphothreonine" [UniProtKB:Q9BRQ0] xref: UniProtKB:Q9BRQ0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006062 ! PYGO2_HUMAN [Term] id: CCO:B0013653 name: QN1_HUMAN-Phosphoserine770 def: "Protein QN1_HUMAN with the residue 770 substituted with Phosphoserine" [UniProtKB:Q5TB80] xref: UniProtKB:Q5TB80 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001883 ! QN1_HUMAN [Term] id: CCO:B0013654 name: QN1_HUMAN-Phosphoserine776 def: "Protein QN1_HUMAN with the residue 776 substituted with Phosphoserine" [UniProtKB:Q5TB80] xref: UniProtKB:Q5TB80 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001883 ! QN1_HUMAN [Term] id: CCO:B0013655 name: RAB1A_HUMAN-N-acetylserine2 def: "Protein RAB1A_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P62820] xref: UniProtKB:P62820 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006222 ! RAB1A_HUMAN [Term] id: CCO:B0013656 name: RAB1A_HUMAN-Phosphoserine194 def: "Protein RAB1A_HUMAN with the residue 194 substituted with Phosphoserine" [UniProtKB:P62820] comment: by CDC2; Probable xref: UniProtKB:P62820 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006222 ! RAB1A_HUMAN [Term] id: CCO:B0013657 name: RAB4A_HUMAN-Phosphoserine199 def: "Protein RAB4A_HUMAN with the residue 199 substituted with Phosphoserine" [UniProtKB:P20338] comment: by CDC2; xref: UniProtKB:P20338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006295 ! RAB4A_HUMAN [Term] id: CCO:B0013658 name: RAB4A_HUMAN-Cysteine methyl ester213 def: "Protein RAB4A_HUMAN with the residue 213 substituted with Cysteine methyl ester" [UniProtKB:P20338] comment: By similarity xref: UniProtKB:P20338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006295 ! RAB4A_HUMAN [Term] id: CCO:B0013659 name: RAC1_HUMAN-ADP-ribosylasparagine39 def: "Protein RAC1_HUMAN with the residue 39 substituted with ADP-ribosylasparagine" [UniProtKB:P63000] comment: by botulinum toxin; By similarity xref: UniProtKB:P63000 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005337 ! RAC1_HUMAN [Term] id: CCO:B0013660 name: RAC1_HUMAN-Cysteine methyl ester189 def: "Protein RAC1_HUMAN with the residue 189 substituted with Cysteine methyl ester" [UniProtKB:P63000] xref: UniProtKB:P63000 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005337 ! RAC1_HUMAN [Term] id: CCO:B0013661 name: RAD17_HUMAN-Phosphothreonine55 def: "Protein RAD17_HUMAN with the residue 55 substituted with Phosphothreonine" [UniProtKB:O75943] comment: By similarity xref: UniProtKB:O75943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001441 ! RAD17_HUMAN [Term] id: CCO:B0013662 name: RAD17_HUMAN-Phosphothreonine304 def: "Protein RAD17_HUMAN with the residue 304 substituted with Phosphothreonine" [UniProtKB:O75943] xref: UniProtKB:O75943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001441 ! RAD17_HUMAN [Term] id: CCO:B0013663 name: RAD17_HUMAN-Phosphoserine646 def: "Protein RAD17_HUMAN with the residue 646 substituted with Phosphoserine" [UniProtKB:O75943] comment: by ATR and ATM; xref: UniProtKB:O75943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001441 ! RAD17_HUMAN [Term] id: CCO:B0013664 name: RAD17_HUMAN-Phosphoserine656 def: "Protein RAD17_HUMAN with the residue 656 substituted with Phosphoserine" [UniProtKB:O75943] comment: by ATR and ATM; xref: UniProtKB:O75943 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001441 ! RAD17_HUMAN [Term] id: CCO:B0013665 name: RAD50_HUMAN-Phosphoserine237 def: "Protein RAD50_HUMAN with the residue 237 substituted with Phosphoserine" [UniProtKB:Q92878] comment: By similarity xref: UniProtKB:Q92878 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002021 ! RAD50_HUMAN [Term] id: CCO:B0013666 name: RAD50_HUMAN-Phosphoserine635 def: "Protein RAD50_HUMAN with the residue 635 substituted with Phosphoserine" [UniProtKB:Q92878] xref: UniProtKB:Q92878 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002021 ! RAD50_HUMAN [Term] id: CCO:B0013667 name: RAD50_HUMAN-Phosphoserine640 def: "Protein RAD50_HUMAN with the residue 640 substituted with Phosphoserine" [UniProtKB:Q92878] xref: UniProtKB:Q92878 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002021 ! RAD50_HUMAN [Term] id: CCO:B0013668 name: RAD50_HUMAN-Phosphothreonine690 def: "Protein RAD50_HUMAN with the residue 690 substituted with Phosphothreonine" [UniProtKB:Q92878] xref: UniProtKB:Q92878 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002021 ! RAD50_HUMAN [Term] id: CCO:B0013669 name: RAD51_HUMAN-Phosphothreonine309 def: "Protein RAD51_HUMAN with the residue 309 substituted with Phosphothreonine" [UniProtKB:Q06609] comment: by CHK1; xref: UniProtKB:Q06609 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:B0013670 name: RAD52_HUMAN-Phosphothreonine318 def: "Protein RAD52_HUMAN with the residue 318 substituted with Phosphothreonine" [UniProtKB:P43351] xref: UniProtKB:P43351 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001621 ! RAD52_HUMAN [Term] id: CCO:B0013671 name: RAD9A_HUMAN-Phosphotyrosine28 def: "Protein RAD9A_HUMAN with the residue 28 substituted with Phosphotyrosine" [UniProtKB:Q99638] xref: UniProtKB:Q99638 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002077 ! RAD9A_HUMAN [Term] id: CCO:B0013672 name: RAD9A_HUMAN-Phosphoserine272 def: "Protein RAD9A_HUMAN with the residue 272 substituted with Phosphoserine" [UniProtKB:Q99638] xref: UniProtKB:Q99638 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002077 ! RAD9A_HUMAN [Term] id: CCO:B0013673 name: RAD9A_HUMAN-Phosphoserine277 def: "Protein RAD9A_HUMAN with the residue 277 substituted with Phosphoserine" [UniProtKB:Q99638] xref: UniProtKB:Q99638 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002077 ! RAD9A_HUMAN [Term] id: CCO:B0013674 name: RAD9A_HUMAN-Phosphoserine328 def: "Protein RAD9A_HUMAN with the residue 328 substituted with Phosphoserine" [UniProtKB:Q99638] xref: UniProtKB:Q99638 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002077 ! RAD9A_HUMAN [Term] id: CCO:B0013675 name: RAD9A_HUMAN-Phosphoserine341 def: "Protein RAD9A_HUMAN with the residue 341 substituted with Phosphoserine" [UniProtKB:Q99638] xref: UniProtKB:Q99638 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002077 ! RAD9A_HUMAN [Term] id: CCO:B0013676 name: RAD9A_HUMAN-Phosphoserine375 def: "Protein RAD9A_HUMAN with the residue 375 substituted with Phosphoserine" [UniProtKB:Q99638] xref: UniProtKB:Q99638 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002077 ! RAD9A_HUMAN [Term] id: CCO:B0013677 name: RAD9A_HUMAN-Phosphoserine380 def: "Protein RAD9A_HUMAN with the residue 380 substituted with Phosphoserine" [UniProtKB:Q99638] xref: UniProtKB:Q99638 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002077 ! RAD9A_HUMAN [Term] id: CCO:B0013678 name: RAD9A_HUMAN-Phosphoserine387 def: "Protein RAD9A_HUMAN with the residue 387 substituted with Phosphoserine" [UniProtKB:Q99638] xref: UniProtKB:Q99638 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002077 ! RAD9A_HUMAN [Term] id: CCO:B0013679 name: RAF1_HUMAN-Phosphoserine43 def: "Protein RAF1_HUMAN with the residue 43 substituted with Phosphoserine" [UniProtKB:P04049] xref: UniProtKB:P04049 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:B0013680 name: RAF1_HUMAN-Phosphoserine252 def: "Protein RAF1_HUMAN with the residue 252 substituted with Phosphoserine" [UniProtKB:P04049] xref: UniProtKB:P04049 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:B0013681 name: RAF1_HUMAN-Phosphoserine259 def: "Protein RAF1_HUMAN with the residue 259 substituted with Phosphoserine" [UniProtKB:P04049] comment: by PKC; xref: UniProtKB:P04049 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:B0013682 name: RAF1_HUMAN-Phosphothreonine268 def: "Protein RAF1_HUMAN with the residue 268 substituted with Phosphothreonine" [UniProtKB:P04049] comment: by autocatalysis; xref: UniProtKB:P04049 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:B0013683 name: RAF1_HUMAN-Phosphoserine294 def: "Protein RAF1_HUMAN with the residue 294 substituted with Phosphoserine" [UniProtKB:P04049] xref: UniProtKB:P04049 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:B0013684 name: RAF1_HUMAN-Phosphoserine301 def: "Protein RAF1_HUMAN with the residue 301 substituted with Phosphoserine" [UniProtKB:P04049] xref: UniProtKB:P04049 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:B0013685 name: RAF1_HUMAN-Phosphoserine338 def: "Protein RAF1_HUMAN with the residue 338 substituted with Phosphoserine" [UniProtKB:P04049] comment: by PAK2 and PAK3; xref: UniProtKB:P04049 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:B0013686 name: RAF1_HUMAN-Phosphoserine499 def: "Protein RAF1_HUMAN with the residue 499 substituted with Phosphoserine" [UniProtKB:P04049] comment: by PKC; xref: UniProtKB:P04049 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:B0013687 name: RAF1_HUMAN-Phosphoserine621 def: "Protein RAF1_HUMAN with the residue 621 substituted with Phosphoserine" [UniProtKB:P04049] xref: UniProtKB:P04049 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:B0013688 name: RAI1_HUMAN-Phosphoserine568 def: "Protein RAI1_HUMAN with the residue 568 substituted with Phosphoserine" [UniProtKB:Q7Z5J4] xref: UniProtKB:Q7Z5J4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005192 ! RAI1_HUMAN [Term] id: CCO:B0013689 name: RAI1_HUMAN-Phosphoserine571 def: "Protein RAI1_HUMAN with the residue 571 substituted with Phosphoserine" [UniProtKB:Q7Z5J4] xref: UniProtKB:Q7Z5J4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005192 ! RAI1_HUMAN [Term] id: CCO:B0013690 name: RAI1_HUMAN-Phosphoserine574 def: "Protein RAI1_HUMAN with the residue 574 substituted with Phosphoserine" [UniProtKB:Q7Z5J4] xref: UniProtKB:Q7Z5J4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005192 ! RAI1_HUMAN [Term] id: CCO:B0013691 name: RAI1_HUMAN-Phosphothreonine1476 def: "Protein RAI1_HUMAN with the residue 1476 substituted with Phosphothreonine" [UniProtKB:Q7Z5J4] xref: UniProtKB:Q7Z5J4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005192 ! RAI1_HUMAN [Term] id: CCO:B0013692 name: RANB3_HUMAN-Phosphoserine96 def: "Protein RANB3_HUMAN with the residue 96 substituted with Phosphoserine" [UniProtKB:Q9H6Z4] xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0013693 name: RANB3_HUMAN-Phosphoserine100 def: "Protein RANB3_HUMAN with the residue 100 substituted with Phosphoserine" [UniProtKB:Q9H6Z4] xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0013694 name: RANB3_HUMAN-Phosphoserine101 def: "Protein RANB3_HUMAN with the residue 101 substituted with Phosphoserine" [UniProtKB:Q9H6Z4] xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0013695 name: RANB3_HUMAN-Phosphoserine108 def: "Protein RANB3_HUMAN with the residue 108 substituted with Phosphoserine" [UniProtKB:Q9H6Z4] xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0013696 name: RANB3_HUMAN-Phosphotyrosine115 def: "Protein RANB3_HUMAN with the residue 115 substituted with Phosphotyrosine" [UniProtKB:Q9H6Z4] comment: By similarity xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0013697 name: RANB3_HUMAN-Phosphoserine126 def: "Protein RANB3_HUMAN with the residue 126 substituted with Phosphoserine" [UniProtKB:Q9H6Z4] xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0013698 name: RANB3_HUMAN-Phosphoserine133 def: "Protein RANB3_HUMAN with the residue 133 substituted with Phosphoserine" [UniProtKB:Q9H6Z4] xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0013699 name: RANB3_HUMAN-Phosphoserine221 def: "Protein RANB3_HUMAN with the residue 221 substituted with Phosphoserine" [UniProtKB:Q9H6Z4] comment: By similarity xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0013700 name: RANB3_HUMAN-Phosphoserine359 def: "Protein RANB3_HUMAN with the residue 359 substituted with Phosphoserine" [UniProtKB:Q9H6Z4] xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0013701 name: RANG_HUMAN-Phosphothreonine13 def: "Protein RANG_HUMAN with the residue 13 substituted with Phosphothreonine" [UniProtKB:P43487] xref: UniProtKB:P43487 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005653 ! RANG_HUMAN [Term] id: CCO:B0013702 name: RANG_HUMAN-Phosphoserine14 def: "Protein RANG_HUMAN with the residue 14 substituted with Phosphoserine" [UniProtKB:P43487] xref: UniProtKB:P43487 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005653 ! RANG_HUMAN [Term] id: CCO:B0013703 name: RANG_HUMAN-Phosphothreonine15 def: "Protein RANG_HUMAN with the residue 15 substituted with Phosphothreonine" [UniProtKB:P43487] xref: UniProtKB:P43487 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005653 ! RANG_HUMAN [Term] id: CCO:B0013704 name: RANG_HUMAN-Phosphothreonine18 def: "Protein RANG_HUMAN with the residue 18 substituted with Phosphothreonine" [UniProtKB:P43487] xref: UniProtKB:P43487 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005653 ! RANG_HUMAN [Term] id: CCO:B0013705 name: RANG_HUMAN-Phosphoserine21 def: "Protein RANG_HUMAN with the residue 21 substituted with Phosphoserine" [UniProtKB:P43487] xref: UniProtKB:P43487 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005653 ! RANG_HUMAN [Term] id: CCO:B0013706 name: RANG_HUMAN-Phosphoserine60 def: "Protein RANG_HUMAN with the residue 60 substituted with Phosphoserine" [UniProtKB:P43487] comment: By similarity xref: UniProtKB:P43487 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005653 ! RANG_HUMAN [Term] id: CCO:B0013707 name: RAN_HUMAN-N-acetylalanine2 def: "Protein RAN_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P62826] xref: UniProtKB:P62826 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001693 ! RAN_HUMAN [Term] id: CCO:B0013708 name: RAN_HUMAN-Phosphotyrosine147 def: "Protein RAN_HUMAN with the residue 147 substituted with Phosphotyrosine" [UniProtKB:P62826] xref: UniProtKB:P62826 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001693 ! RAN_HUMAN [Term] id: CCO:B0013709 name: RAP1A_HUMAN-Cysteine methyl ester181 def: "Protein RAP1A_HUMAN with the residue 181 substituted with Cysteine methyl ester" [UniProtKB:P62834] xref: UniProtKB:P62834 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000427 ! GTPase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: transformation_of CCO:B0001694 ! RAP1A_HUMAN [Term] id: CCO:B0013715 name: RASH_HUMAN-Cysteine methyl ester186 def: "Protein RASH_HUMAN with the residue 186 substituted with Cysteine methyl ester" [UniProtKB:P01112] xref: UniProtKB:P01112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001467 ! RASH_HUMAN [Term] id: CCO:B0013716 name: RASK_HUMAN-ester186 def: "Protein RASK_HUMAN with the residue 186 substituted with ester" [UniProtKB:P01116] comment: in isoform 2A; xref: UniProtKB:P01116 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001468 ! RASK_HUMAN [Term] id: CCO:B0013718 name: RB27A_HUMAN-Cysteine methyl ester221 def: "Protein RB27A_HUMAN with the residue 221 substituted with Cysteine methyl ester" [UniProtKB:P51159] comment: By similarity xref: UniProtKB:P51159 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006223 ! RB27A_HUMAN [Term] id: CCO:B0013719 name: RBBP4_HUMAN-N-acetylalanine2 def: "Protein RBBP4_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q09028] xref: UniProtKB:Q09028 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001727 ! RBBP4_HUMAN [Term] id: CCO:B0013720 name: RBBP5_HUMAN-Phosphoserine182 def: "Protein RBBP5_HUMAN with the residue 182 substituted with Phosphoserine" [UniProtKB:Q15291] xref: UniProtKB:Q15291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:B0013721 name: RBBP5_HUMAN-Phosphothreonine193 def: "Protein RBBP5_HUMAN with the residue 193 substituted with Phosphothreonine" [UniProtKB:Q15291] xref: UniProtKB:Q15291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:B0013722 name: RBBP5_HUMAN-Phosphothreonine252 def: "Protein RBBP5_HUMAN with the residue 252 substituted with Phosphothreonine" [UniProtKB:Q15291] comment: by CDC2; xref: UniProtKB:Q15291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:B0013723 name: RBBP5_HUMAN-Phosphoserine350 def: "Protein RBBP5_HUMAN with the residue 350 substituted with Phosphoserine" [UniProtKB:Q15291] xref: UniProtKB:Q15291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:B0013724 name: RBBP5_HUMAN-Phosphoserine388 def: "Protein RBBP5_HUMAN with the residue 388 substituted with Phosphoserine" [UniProtKB:Q15291] xref: UniProtKB:Q15291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:B0013725 name: RBBP5_HUMAN-Phosphoserine389 def: "Protein RBBP5_HUMAN with the residue 389 substituted with Phosphoserine" [UniProtKB:Q15291] xref: UniProtKB:Q15291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:B0013726 name: RBBP5_HUMAN-Phosphoserine497 def: "Protein RBBP5_HUMAN with the residue 497 substituted with Phosphoserine" [UniProtKB:Q15291] comment: by CDC2; xref: UniProtKB:Q15291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:B0013744 name: RBBP7_HUMAN-N6-acetyllysine119 def: "Protein RBBP7_HUMAN with the residue 119 substituted with N6-acetyllysine" [UniProtKB:Q16576] xref: UniProtKB:Q16576 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005809 ! RBBP7_HUMAN [Term] id: CCO:B0013745 name: RBBP7_HUMAN-Phosphoserine413 def: "Protein RBBP7_HUMAN with the residue 413 substituted with Phosphoserine" [UniProtKB:Q16576] xref: UniProtKB:Q16576 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005809 ! RBBP7_HUMAN [Term] id: CCO:B0013746 name: RBBP7_HUMAN-Phosphothreonine416 def: "Protein RBBP7_HUMAN with the residue 416 substituted with Phosphothreonine" [UniProtKB:Q16576] xref: UniProtKB:Q16576 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005809 ! RBBP7_HUMAN [Term] id: CCO:B0013747 name: RBBP8_HUMAN-Phosphoserine327 def: "Protein RBBP8_HUMAN with the residue 327 substituted with Phosphoserine" [UniProtKB:Q99708] xref: UniProtKB:Q99708 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002084 ! RBBP8_HUMAN [Term] id: CCO:B0013748 name: RBBP8_HUMAN-Phosphoserine664 def: "Protein RBBP8_HUMAN with the residue 664 substituted with Phosphoserine" [UniProtKB:Q99708] comment: by ATM; xref: UniProtKB:Q99708 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002084 ! RBBP8_HUMAN [Term] id: CCO:B0013749 name: RBBP8_HUMAN-Phosphoserine679 def: "Protein RBBP8_HUMAN with the residue 679 substituted with Phosphoserine" [UniProtKB:Q99708] xref: UniProtKB:Q99708 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002084 ! RBBP8_HUMAN [Term] id: CCO:B0013750 name: RBBP8_HUMAN-Phosphoserine745 def: "Protein RBBP8_HUMAN with the residue 745 substituted with Phosphoserine" [UniProtKB:Q99708] comment: by ATM; xref: UniProtKB:Q99708 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002084 ! RBBP8_HUMAN [Term] id: CCO:B0013751 name: RBCC1_HUMAN-Phosphoserine237 def: "Protein RBCC1_HUMAN with the residue 237 substituted with Phosphoserine" [UniProtKB:Q8TDY2] comment: By similarity xref: UniProtKB:Q8TDY2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001995 ! RBCC1_HUMAN [Term] id: CCO:B0013752 name: RBCC1_HUMAN-Phosphoserine537 def: "Protein RBCC1_HUMAN with the residue 537 substituted with Phosphoserine" [UniProtKB:Q8TDY2] xref: UniProtKB:Q8TDY2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001995 ! RBCC1_HUMAN [Term] id: CCO:B0013753 name: RBCC1_HUMAN-Phosphothreonine666 def: "Protein RBCC1_HUMAN with the residue 666 substituted with Phosphothreonine" [UniProtKB:Q8TDY2] comment: By similarity xref: UniProtKB:Q8TDY2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001995 ! RBCC1_HUMAN [Term] id: CCO:B0013754 name: RBL1_HUMAN-Phosphothreonine332 def: "Protein RBL1_HUMAN with the residue 332 substituted with Phosphothreonine" [UniProtKB:P28749] comment: by CDK2; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013755 name: RBL1_HUMAN-Phosphothreonine369 def: "Protein RBL1_HUMAN with the residue 369 substituted with Phosphothreonine" [UniProtKB:P28749] comment: by CDK4; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013756 name: RBL1_HUMAN-Phosphothreonine385 def: "Protein RBL1_HUMAN with the residue 385 substituted with Phosphothreonine" [UniProtKB:P28749] comment: by CDK2; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013757 name: RBL1_HUMAN-Phosphoserine640 def: "Protein RBL1_HUMAN with the residue 640 substituted with Phosphoserine" [UniProtKB:P28749] comment: by CDK2 and CDK4; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013758 name: RBL1_HUMAN-Phosphoserine650 def: "Protein RBL1_HUMAN with the residue 650 substituted with Phosphoserine" [UniProtKB:P28749] xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013759 name: RBL1_HUMAN-Phosphoserine762 def: "Protein RBL1_HUMAN with the residue 762 substituted with Phosphoserine" [UniProtKB:P28749] comment: by CDK2; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013760 name: RBL1_HUMAN-Phosphoserine964 def: "Protein RBL1_HUMAN with the residue 964 substituted with Phosphoserine" [UniProtKB:P28749] comment: by CDK2 and CDK4; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013761 name: RBL1_HUMAN-Phosphoserine975 def: "Protein RBL1_HUMAN with the residue 975 substituted with Phosphoserine" [UniProtKB:P28749] comment: by CDK2 and CDK4; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013762 name: RBL1_HUMAN-Phosphoserine988 def: "Protein RBL1_HUMAN with the residue 988 substituted with Phosphoserine" [UniProtKB:P28749] comment: by CDK2; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013763 name: RBL1_HUMAN-Phosphothreonine997 def: "Protein RBL1_HUMAN with the residue 997 substituted with Phosphothreonine" [UniProtKB:P28749] comment: by CDK2; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013764 name: RBL1_HUMAN-Phosphoserine1009 def: "Protein RBL1_HUMAN with the residue 1009 substituted with Phosphoserine" [UniProtKB:P28749] comment: by CDK2; xref: UniProtKB:P28749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001567 ! RBL1_HUMAN [Term] id: CCO:B0013765 name: RBL2_HUMAN-Phosphoserine413 def: "Protein RBL2_HUMAN with the residue 413 substituted with Phosphoserine" [UniProtKB:Q08999] comment: By similarity xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013766 name: RBL2_HUMAN-Phosphothreonine417 def: "Protein RBL2_HUMAN with the residue 417 substituted with Phosphothreonine" [UniProtKB:Q08999] comment: By similarity xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013767 name: RBL2_HUMAN-Phosphoserine639 def: "Protein RBL2_HUMAN with the residue 639 substituted with Phosphoserine" [UniProtKB:Q08999] xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013768 name: RBL2_HUMAN-Phosphothreonine642 def: "Protein RBL2_HUMAN with the residue 642 substituted with Phosphothreonine" [UniProtKB:Q08999] comment: By similarity xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013769 name: RBL2_HUMAN-Phosphoserine672 def: "Protein RBL2_HUMAN with the residue 672 substituted with Phosphoserine" [UniProtKB:Q08999] xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013770 name: RBL2_HUMAN-Phosphoserine948 def: "Protein RBL2_HUMAN with the residue 948 substituted with Phosphoserine" [UniProtKB:Q08999] comment: By similarity xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013771 name: RBL2_HUMAN-Phosphoserine952 def: "Protein RBL2_HUMAN with the residue 952 substituted with Phosphoserine" [UniProtKB:Q08999] xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013772 name: RBL2_HUMAN-Phosphoserine966 def: "Protein RBL2_HUMAN with the residue 966 substituted with Phosphoserine" [UniProtKB:Q08999] xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013773 name: RBL2_HUMAN-Phosphoserine971 def: "Protein RBL2_HUMAN with the residue 971 substituted with Phosphoserine" [UniProtKB:Q08999] comment: Probable xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013774 name: RBL2_HUMAN-Phosphoserine972 def: "Protein RBL2_HUMAN with the residue 972 substituted with Phosphoserine" [UniProtKB:Q08999] comment: Probable xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013775 name: RBL2_HUMAN-Phosphoserine973 def: "Protein RBL2_HUMAN with the residue 973 substituted with Phosphoserine" [UniProtKB:Q08999] comment: Probable xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013776 name: RBL2_HUMAN-Phosphothreonine974 def: "Protein RBL2_HUMAN with the residue 974 substituted with Phosphothreonine" [UniProtKB:Q08999] comment: Probable xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013777 name: RBL2_HUMAN-Phosphoserine981 def: "Protein RBL2_HUMAN with the residue 981 substituted with Phosphoserine" [UniProtKB:Q08999] comment: Probable xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013778 name: RBL2_HUMAN-Phosphoserine982 def: "Protein RBL2_HUMAN with the residue 982 substituted with Phosphoserine" [UniProtKB:Q08999] comment: Probable xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013779 name: RBL2_HUMAN-Phosphothreonine986 def: "Protein RBL2_HUMAN with the residue 986 substituted with Phosphothreonine" [UniProtKB:Q08999] xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0013789 name: RBM5_HUMAN-Phosphoserine59 def: "Protein RBM5_HUMAN with the residue 59 substituted with Phosphoserine" [UniProtKB:P52756] xref: UniProtKB:P52756 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001660 ! RBM5_HUMAN [Term] id: CCO:B0013790 name: RBM5_HUMAN-Phosphoserine69 def: "Protein RBM5_HUMAN with the residue 69 substituted with Phosphoserine" [UniProtKB:P52756] comment: By similarity xref: UniProtKB:P52756 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001660 ! RBM5_HUMAN [Term] id: CCO:B0013791 name: RBM5_HUMAN-Phosphoserine621 def: "Protein RBM5_HUMAN with the residue 621 substituted with Phosphoserine" [UniProtKB:P52756] comment: By similarity xref: UniProtKB:P52756 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001660 ! RBM5_HUMAN [Term] id: CCO:B0013792 name: RBM5_HUMAN-Phosphoserine624 def: "Protein RBM5_HUMAN with the residue 624 substituted with Phosphoserine" [UniProtKB:P52756] xref: UniProtKB:P52756 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001660 ! RBM5_HUMAN [Term] id: CCO:B0013793 name: RBM7_HUMAN-Phosphoserine136 def: "Protein RBM7_HUMAN with the residue 136 substituted with Phosphoserine" [UniProtKB:Q9Y580] xref: UniProtKB:Q9Y580 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002255 ! RBM7_HUMAN [Term] id: CCO:B0013794 name: RBM7_HUMAN-Phosphoserine137 def: "Protein RBM7_HUMAN with the residue 137 substituted with Phosphoserine" [UniProtKB:Q9Y580] xref: UniProtKB:Q9Y580 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002255 ! RBM7_HUMAN [Term] id: CCO:B0013795 name: RBM8A_HUMAN-Phosphoserine42 def: "Protein RBM8A_HUMAN with the residue 42 substituted with Phosphoserine" [UniProtKB:Q9Y5S9] xref: UniProtKB:Q9Y5S9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005223 ! RBM8A_HUMAN [Term] id: CCO:B0013796 name: RBM8A_HUMAN-Phosphoserine46 def: "Protein RBM8A_HUMAN with the residue 46 substituted with Phosphoserine" [UniProtKB:Q9Y5S9] xref: UniProtKB:Q9Y5S9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005223 ! RBM8A_HUMAN [Term] id: CCO:B0013797 name: RBM8A_HUMAN-Phosphoserine166 def: "Protein RBM8A_HUMAN with the residue 166 substituted with Phosphoserine" [UniProtKB:Q9Y5S9] xref: UniProtKB:Q9Y5S9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005223 ! RBM8A_HUMAN [Term] id: CCO:B0013798 name: RBM8A_HUMAN-Phosphoserine168 def: "Protein RBM8A_HUMAN with the residue 168 substituted with Phosphoserine" [UniProtKB:Q9Y5S9] xref: UniProtKB:Q9Y5S9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005223 ! RBM8A_HUMAN [Term] id: CCO:B0013799 name: RB_HUMAN-Phosphoserine249 def: "Protein RB_HUMAN with the residue 249 substituted with Phosphoserine" [UniProtKB:P06400] comment: by CDC2; xref: UniProtKB:P06400 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001491 ! RB_HUMAN [Term] id: CCO:B0013800 name: RB_HUMAN-Phosphothreonine252 def: "Protein RB_HUMAN with the residue 252 substituted with Phosphothreonine" [UniProtKB:P06400] comment: by CDC2; xref: UniProtKB:P06400 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001491 ! RB_HUMAN [Term] id: CCO:B0013801 name: RB_HUMAN-Phosphothreonine373 def: "Protein RB_HUMAN with the residue 373 substituted with Phosphothreonine" [UniProtKB:P06400] comment: by CDC2; xref: UniProtKB:P06400 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001491 ! RB_HUMAN [Term] id: CCO:B0013802 name: RB_HUMAN-Phosphoserine807 def: "Protein RB_HUMAN with the residue 807 substituted with Phosphoserine" [UniProtKB:P06400] comment: by CDC2; xref: UniProtKB:P06400 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001491 ! RB_HUMAN [Term] id: CCO:B0013803 name: RB_HUMAN-Phosphoserine811 def: "Protein RB_HUMAN with the residue 811 substituted with Phosphoserine" [UniProtKB:P06400] comment: by CDC2; xref: UniProtKB:P06400 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001491 ! RB_HUMAN [Term] id: CCO:B0013804 name: RB_HUMAN-Phosphothreonine826 def: "Protein RB_HUMAN with the residue 826 substituted with Phosphothreonine" [UniProtKB:P06400] comment: By similarity xref: UniProtKB:P06400 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001491 ! RB_HUMAN [Term] id: CCO:B0013805 name: RCC1_HUMAN-Phosphoserine11 def: "Protein RCC1_HUMAN with the residue 11 substituted with Phosphoserine" [UniProtKB:P18754] xref: UniProtKB:P18754 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001533 ! RCC1_HUMAN [Term] id: CCO:B0013806 name: RCC1_HUMAN-Phosphoserine403 def: "Protein RCC1_HUMAN with the residue 403 substituted with Phosphoserine" [UniProtKB:P18754] xref: UniProtKB:P18754 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001533 ! RCC1_HUMAN [Term] id: CCO:B0013807 name: RCC1_HUMAN-Phosphoserine405 def: "Protein RCC1_HUMAN with the residue 405 substituted with Phosphoserine" [UniProtKB:P18754] xref: UniProtKB:P18754 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001533 ! RCC1_HUMAN [Term] id: CCO:B0013808 name: RCC1_HUMAN-Phosphoserine406 def: "Protein RCC1_HUMAN with the residue 406 substituted with Phosphoserine" [UniProtKB:P18754] xref: UniProtKB:P18754 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000278 ! chromatin binding relationship: has_function CCO:F0001390 ! guanyl-nucleotide exchange factor activity relationship: has_function CCO:F0001392 ! Ran guanyl-nucleotide exchange factor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0005669 ! histone binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000117 ! nuclear chromatin relationship: located_in CCO:C0000121 ! condensed nuclear chromosome relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001533 ! RCC1_HUMAN [Term] id: CCO:B0013809 name: RCC1_HUMAN-Phosphothreonine411 def: "Protein RCC1_HUMAN with the residue 411 substituted with Phosphothreonine" [UniProtKB:P18754] xref: UniProtKB:P18754 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001533 ! RCC1_HUMAN [Term] id: CCO:B0013810 name: RCC2_HUMAN-Phosphothreonine20 def: "Protein RCC2_HUMAN with the residue 20 substituted with Phosphothreonine" [UniProtKB:Q9P258] xref: UniProtKB:Q9P258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000434 ! microtubule relationship: transformation_of CCO:B0002186 ! RCC2_HUMAN [Term] id: CCO:B0013811 name: RCC2_HUMAN-Phosphoserine43 def: "Protein RCC2_HUMAN with the residue 43 substituted with Phosphoserine" [UniProtKB:Q9P258] xref: UniProtKB:Q9P258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002186 ! RCC2_HUMAN [Term] id: CCO:B0013812 name: RCC2_HUMAN-Phosphoserine44 def: "Protein RCC2_HUMAN with the residue 44 substituted with Phosphoserine" [UniProtKB:Q9P258] xref: UniProtKB:Q9P258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002186 ! RCC2_HUMAN [Term] id: CCO:B0013813 name: RCC2_HUMAN-Phosphoserine45 def: "Protein RCC2_HUMAN with the residue 45 substituted with Phosphoserine" [UniProtKB:Q9P258] xref: UniProtKB:Q9P258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002186 ! RCC2_HUMAN [Term] id: CCO:B0013814 name: RCC2_HUMAN-Phosphoserine46 def: "Protein RCC2_HUMAN with the residue 46 substituted with Phosphoserine" [UniProtKB:Q9P258] xref: UniProtKB:Q9P258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002186 ! RCC2_HUMAN [Term] id: CCO:B0013815 name: RCC2_HUMAN-Phosphoserine50 def: "Protein RCC2_HUMAN with the residue 50 substituted with Phosphoserine" [UniProtKB:Q9P258] xref: UniProtKB:Q9P258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002186 ! RCC2_HUMAN [Term] id: CCO:B0013816 name: RCC2_HUMAN-Phosphoserine51 def: "Protein RCC2_HUMAN with the residue 51 substituted with Phosphoserine" [UniProtKB:Q9P258] xref: UniProtKB:Q9P258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002186 ! RCC2_HUMAN [Term] id: CCO:B0013817 name: RCC2_HUMAN-Phosphoserine347 def: "Protein RCC2_HUMAN with the residue 347 substituted with Phosphoserine" [UniProtKB:Q9P258] xref: UniProtKB:Q9P258 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002186 ! RCC2_HUMAN [Term] id: CCO:B0013818 name: RED_HUMAN-Phosphothreonine485 def: "Protein RED_HUMAN with the residue 485 substituted with Phosphothreonine" [UniProtKB:Q13123] xref: UniProtKB:Q13123 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006239 ! RED_HUMAN [Term] id: CCO:B0013819 name: RENT1_HUMAN-Phosphoserine1089 def: "Protein RENT1_HUMAN with the residue 1089 substituted with Phosphoserine" [UniProtKB:Q92900] comment: Probable xref: UniProtKB:Q92900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002024 ! RENT1_HUMAN [Term] id: CCO:B0013820 name: RENT1_HUMAN-Phosphoserine1107 def: "Protein RENT1_HUMAN with the residue 1107 substituted with Phosphoserine" [UniProtKB:Q92900] xref: UniProtKB:Q92900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002024 ! RENT1_HUMAN [Term] id: CCO:B0013821 name: RENT1_HUMAN-Phosphoserine1127 def: "Protein RENT1_HUMAN with the residue 1127 substituted with Phosphoserine" [UniProtKB:Q92900] xref: UniProtKB:Q92900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002024 ! RENT1_HUMAN [Term] id: CCO:B0013822 name: RFA1_HUMAN-Phosphothreonine180 def: "Protein RFA1_HUMAN with the residue 180 substituted with Phosphothreonine" [UniProtKB:P27694] xref: UniProtKB:P27694 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001562 ! RFA1_HUMAN [Term] id: CCO:B0013823 name: RFA2_HUMAN-N-acetylmethionine1 def: "Protein RFA2_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P15927] xref: UniProtKB:P15927 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005500 ! RFA2_HUMAN [Term] id: CCO:B0013824 name: RFA2_HUMAN-Phosphothreonine21 def: "Protein RFA2_HUMAN with the residue 21 substituted with Phosphothreonine" [UniProtKB:P15927] comment: by PRKDC; in vitro; xref: UniProtKB:P15927 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005500 ! RFA2_HUMAN [Term] id: CCO:B0013825 name: RFA2_HUMAN-Phosphoserine29 def: "Protein RFA2_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:P15927] comment: by CDC2; in vitro; xref: UniProtKB:P15927 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005500 ! RFA2_HUMAN [Term] id: CCO:B0013826 name: RFA2_HUMAN-Phosphoserine33 def: "Protein RFA2_HUMAN with the residue 33 substituted with Phosphoserine" [UniProtKB:P15927] comment: by PRKDC; in vitro; xref: UniProtKB:P15927 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005500 ! RFA2_HUMAN [Term] id: CCO:B0013827 name: RFC1_HUMAN-Phosphoserine69 def: "Protein RFC1_HUMAN with the residue 69 substituted with Phosphoserine" [UniProtKB:P35251] xref: UniProtKB:P35251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:B0013828 name: RFC1_HUMAN-Phosphoserine71 def: "Protein RFC1_HUMAN with the residue 71 substituted with Phosphoserine" [UniProtKB:P35251] xref: UniProtKB:P35251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:B0013829 name: RFC1_HUMAN-Phosphoserine73 def: "Protein RFC1_HUMAN with the residue 73 substituted with Phosphoserine" [UniProtKB:P35251] xref: UniProtKB:P35251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:B0013830 name: RFC1_HUMAN-Phosphoserine108 def: "Protein RFC1_HUMAN with the residue 108 substituted with Phosphoserine" [UniProtKB:P35251] xref: UniProtKB:P35251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:B0013831 name: RFC1_HUMAN-Phosphothreonine110 def: "Protein RFC1_HUMAN with the residue 110 substituted with Phosphothreonine" [UniProtKB:P35251] comment: By similarity xref: UniProtKB:P35251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:B0013832 name: RFC1_HUMAN-Phosphoserine156 def: "Protein RFC1_HUMAN with the residue 156 substituted with Phosphoserine" [UniProtKB:P35251] xref: UniProtKB:P35251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:B0013833 name: RFC1_HUMAN-Phosphothreonine161 def: "Protein RFC1_HUMAN with the residue 161 substituted with Phosphothreonine" [UniProtKB:P35251] xref: UniProtKB:P35251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:B0013834 name: RFC1_HUMAN-Phosphoserine173 def: "Protein RFC1_HUMAN with the residue 173 substituted with Phosphoserine" [UniProtKB:P35251] xref: UniProtKB:P35251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:B0013835 name: RFC1_HUMAN-Phosphoserine190 def: "Protein RFC1_HUMAN with the residue 190 substituted with Phosphoserine" [UniProtKB:P35251] xref: UniProtKB:P35251 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:B0013837 name: RGAP1_HUMAN-Phosphothreonine161 def: "Protein RGAP1_HUMAN with the residue 161 substituted with Phosphothreonine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013838 name: RGAP1_HUMAN-Phosphoserine164 def: "Protein RGAP1_HUMAN with the residue 164 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013839 name: RGAP1_HUMAN-Phosphoserine170 def: "Protein RGAP1_HUMAN with the residue 170 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013840 name: RGAP1_HUMAN-Phosphoserine185 def: "Protein RGAP1_HUMAN with the residue 185 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013841 name: RGAP1_HUMAN-Phosphoserine187 def: "Protein RGAP1_HUMAN with the residue 187 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013842 name: RGAP1_HUMAN-Phosphoserine203 def: "Protein RGAP1_HUMAN with the residue 203 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013843 name: RGAP1_HUMAN-Phosphoserine206 def: "Protein RGAP1_HUMAN with the residue 206 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013844 name: RGAP1_HUMAN-Phosphoserine214 def: "Protein RGAP1_HUMAN with the residue 214 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013845 name: RGAP1_HUMAN-Phosphothreonine342 def: "Protein RGAP1_HUMAN with the residue 342 substituted with Phosphothreonine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013846 name: RGAP1_HUMAN-Phosphoserine387 def: "Protein RGAP1_HUMAN with the residue 387 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013847 name: RGAP1_HUMAN-Phosphothreonine580 def: "Protein RGAP1_HUMAN with the residue 580 substituted with Phosphothreonine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013848 name: RGAP1_HUMAN-Phosphothreonine588 def: "Protein RGAP1_HUMAN with the residue 588 substituted with Phosphothreonine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013849 name: RGAP1_HUMAN-Phosphoserine590 def: "Protein RGAP1_HUMAN with the residue 590 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013850 name: RGAP1_HUMAN-Phosphothreonine606 def: "Protein RGAP1_HUMAN with the residue 606 substituted with Phosphothreonine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013851 name: RGAP1_HUMAN-Phosphoserine628 def: "Protein RGAP1_HUMAN with the residue 628 substituted with Phosphoserine" [UniProtKB:Q9H0H5] xref: UniProtKB:Q9H0H5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:B0013852 name: RGC32_HUMAN-Phosphoserine9 def: "Protein RGC32_HUMAN with the residue 9 substituted with Phosphoserine" [UniProtKB:Q9H4X1] xref: UniProtKB:Q9H4X1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002137 ! RGC32_HUMAN [Term] id: CCO:B0013853 name: RGC32_HUMAN-Phosphoserine29 def: "Protein RGC32_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:Q9H4X1] xref: UniProtKB:Q9H4X1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002137 ! RGC32_HUMAN [Term] id: CCO:B0013854 name: RGC32_HUMAN-Phosphoserine44 def: "Protein RGC32_HUMAN with the residue 44 substituted with Phosphoserine" [UniProtKB:Q9H4X1] xref: UniProtKB:Q9H4X1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002137 ! RGC32_HUMAN [Term] id: CCO:B0013855 name: RGC32_HUMAN-Phosphothreonine111 def: "Protein RGC32_HUMAN with the residue 111 substituted with Phosphothreonine" [UniProtKB:Q9H4X1] comment: by CDC2; xref: UniProtKB:Q9H4X1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: transformation_of CCO:B0002137 ! RGC32_HUMAN [Term] id: CCO:B0013856 name: RHOB_HUMAN-ADP-ribosylasparagine41 def: "Protein RHOB_HUMAN with the residue 41 substituted with ADP-ribosylasparagine" [UniProtKB:P62745] comment: by botulinum toxin; By similarity xref: UniProtKB:P62745 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001692 ! RHOB_HUMAN [Term] id: CCO:B0013857 name: RHOB_HUMAN-Cysteine methyl ester193 def: "Protein RHOB_HUMAN with the residue 193 substituted with Cysteine methyl ester" [UniProtKB:P62745] xref: UniProtKB:P62745 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001692 ! RHOB_HUMAN [Term] id: CCO:B0013860 name: RIF1_HUMAN-Phosphoserine782 def: "Protein RIF1_HUMAN with the residue 782 substituted with Phosphoserine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013861 name: RIF1_HUMAN-Phosphoserine1454 def: "Protein RIF1_HUMAN with the residue 1454 substituted with Phosphoserine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013862 name: RIF1_HUMAN-Phosphoserine1513 def: "Protein RIF1_HUMAN with the residue 1513 substituted with Phosphoserine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013863 name: RIF1_HUMAN-Phosphothreonine1518 def: "Protein RIF1_HUMAN with the residue 1518 substituted with Phosphothreonine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013864 name: RIF1_HUMAN-Phosphoserine1542 def: "Protein RIF1_HUMAN with the residue 1542 substituted with Phosphoserine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013865 name: RIF1_HUMAN-Phosphoserine1579 def: "Protein RIF1_HUMAN with the residue 1579 substituted with Phosphoserine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013866 name: RIF1_HUMAN-Phosphoserine1688 def: "Protein RIF1_HUMAN with the residue 1688 substituted with Phosphoserine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013867 name: RIF1_HUMAN-Phosphoserine1851 def: "Protein RIF1_HUMAN with the residue 1851 substituted with Phosphoserine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013868 name: RIF1_HUMAN-Phosphoserine2161 def: "Protein RIF1_HUMAN with the residue 2161 substituted with Phosphoserine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013869 name: RIF1_HUMAN-Phosphoserine2243 def: "Protein RIF1_HUMAN with the residue 2243 substituted with Phosphoserine" [UniProtKB:Q5UIP0] xref: UniProtKB:Q5UIP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:B0013870 name: RIN1_HUMAN-Phosphotyrosine36 def: "Protein RIN1_HUMAN with the residue 36 substituted with Phosphotyrosine" [UniProtKB:Q13671] xref: UniProtKB:Q13671 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005385 ! RIN1_HUMAN [Term] id: CCO:B0013871 name: RIN1_HUMAN-Phosphoserine333 def: "Protein RIN1_HUMAN with the residue 333 substituted with Phosphoserine" [UniProtKB:Q13671] xref: UniProtKB:Q13671 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005385 ! RIN1_HUMAN [Term] id: CCO:B0013872 name: RIN1_HUMAN-Phosphoserine337 def: "Protein RIN1_HUMAN with the residue 337 substituted with Phosphoserine" [UniProtKB:Q13671] xref: UniProtKB:Q13671 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005385 ! RIN1_HUMAN [Term] id: CCO:B0013873 name: RIN1_HUMAN-Phosphoserine351 def: "Protein RIN1_HUMAN with the residue 351 substituted with Phosphoserine" [UniProtKB:Q13671] comment: by PKD; xref: UniProtKB:Q13671 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005385 ! RIN1_HUMAN [Term] id: CCO:B0013874 name: RIN1_HUMAN-Phosphoserine601 def: "Protein RIN1_HUMAN with the residue 601 substituted with Phosphoserine" [UniProtKB:Q13671] comment: By similarity xref: UniProtKB:Q13671 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005385 ! RIN1_HUMAN [Term] id: CCO:B0013878 name: RIPK2_HUMAN-Phosphoserine176 def: "Protein RIPK2_HUMAN with the residue 176 substituted with Phosphoserine" [UniProtKB:O43353] xref: UniProtKB:O43353 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005216 ! RIPK2_HUMAN [Term] id: CCO:B0013879 name: RIPK2_HUMAN-Phosphoserine531 def: "Protein RIPK2_HUMAN with the residue 531 substituted with Phosphoserine" [UniProtKB:O43353] xref: UniProtKB:O43353 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005216 ! RIPK2_HUMAN [Term] id: CCO:B0013880 name: RL11_HUMAN-N-acetylalanine2 def: "Protein RL11_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P62913] xref: UniProtKB:P62913 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005858 ! RL11_HUMAN [Term] id: CCO:B0013881 name: RL12_HUMAN-Phosphotyrosine14 def: "Protein RL12_HUMAN with the residue 14 substituted with Phosphotyrosine" [UniProtKB:P30050] xref: UniProtKB:P30050 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005855 ! RL12_HUMAN [Term] id: CCO:B0013882 name: RL12_HUMAN-Phosphoserine38 def: "Protein RL12_HUMAN with the residue 38 substituted with Phosphoserine" [UniProtKB:P30050] xref: UniProtKB:P30050 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005855 ! RL12_HUMAN [Term] id: CCO:B0013883 name: RL12_HUMAN-Phosphoserine165 def: "Protein RL12_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:P30050] xref: UniProtKB:P30050 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005855 ! RL12_HUMAN [Term] id: CCO:B0013886 name: RL18_HUMAN-Phosphoserine130 def: "Protein RL18_HUMAN with the residue 130 substituted with Phosphoserine" [UniProtKB:Q07020] xref: UniProtKB:Q07020 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005741 ! RL18_HUMAN [Term] id: CCO:B0013887 name: RL24_HUMAN-Phosphothreonine83 def: "Protein RL24_HUMAN with the residue 83 substituted with Phosphothreonine" [UniProtKB:P83731] xref: UniProtKB:P83731 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005856 ! RL24_HUMAN [Term] id: CCO:B0013888 name: RL24_HUMAN-Phosphoserine86 def: "Protein RL24_HUMAN with the residue 86 substituted with Phosphoserine" [UniProtKB:P83731] xref: UniProtKB:P83731 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005856 ! RL24_HUMAN [Term] id: CCO:B0013889 name: RL28_HUMAN-N-acetylserine2 def: "Protein RL28_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P46779] xref: UniProtKB:P46779 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005853 ! RL28_HUMAN [Term] id: CCO:B0013890 name: RL4_HUMAN-N-acetylalanine2 def: "Protein RL4_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P36578] xref: UniProtKB:P36578 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005861 ! RL4_HUMAN [Term] id: CCO:B0013891 name: RL4_HUMAN-Phosphoserine295 def: "Protein RL4_HUMAN with the residue 295 substituted with Phosphoserine" [UniProtKB:P36578] xref: UniProtKB:P36578 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005861 ! RL4_HUMAN [Term] id: CCO:B0013892 name: RL7_HUMAN-N-acetylmethionine1 def: "Protein RL7_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P18124] comment: By similarity xref: UniProtKB:P18124 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005746 ! RL7_HUMAN [Term] id: CCO:B0013893 name: RL7_HUMAN-Phosphotyrosine139 def: "Protein RL7_HUMAN with the residue 139 substituted with Phosphotyrosine" [UniProtKB:P18124] xref: UniProtKB:P18124 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005746 ! RL7_HUMAN [Term] id: CCO:B0013894 name: RL7_HUMAN-Phosphotyrosine195 def: "Protein RL7_HUMAN with the residue 195 substituted with Phosphotyrosine" [UniProtKB:P18124] xref: UniProtKB:P18124 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005746 ! RL7_HUMAN [Term] id: CCO:B0013895 name: RL8_HUMAN-Phosphotyrosine133 def: "Protein RL8_HUMAN with the residue 133 substituted with Phosphotyrosine" [UniProtKB:P62917] xref: UniProtKB:P62917 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005860 ! RL8_HUMAN [Term] id: CCO:B0013896 name: RLA0_HUMAN-Phosphotyrosine24 def: "Protein RLA0_HUMAN with the residue 24 substituted with Phosphotyrosine" [UniProtKB:P05388] xref: UniProtKB:P05388 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005762 ! RLA0_HUMAN [Term] id: CCO:B0013897 name: RLA0_HUMAN-Phosphoserine304 def: "Protein RLA0_HUMAN with the residue 304 substituted with Phosphoserine" [UniProtKB:P05388] xref: UniProtKB:P05388 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005762 ! RLA0_HUMAN [Term] id: CCO:B0013898 name: RLA0_HUMAN-Phosphoserine307 def: "Protein RLA0_HUMAN with the residue 307 substituted with Phosphoserine" [UniProtKB:P05388] xref: UniProtKB:P05388 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005762 ! RLA0_HUMAN [Term] id: CCO:B0013899 name: RLA1_HUMAN-Phosphoserine5 def: "Protein RLA1_HUMAN with the residue 5 substituted with Phosphoserine" [UniProtKB:P05386] xref: UniProtKB:P05386 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005770 ! RLA1_HUMAN [Term] id: CCO:B0013900 name: RLA1_HUMAN-Phosphotyrosine11 def: "Protein RLA1_HUMAN with the residue 11 substituted with Phosphotyrosine" [UniProtKB:P05386] xref: UniProtKB:P05386 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005770 ! RLA1_HUMAN [Term] id: CCO:B0013901 name: RLA1_HUMAN-Phosphoserine12 def: "Protein RLA1_HUMAN with the residue 12 substituted with Phosphoserine" [UniProtKB:P05386] xref: UniProtKB:P05386 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005770 ! RLA1_HUMAN [Term] id: CCO:B0013902 name: RLA1_HUMAN-Phosphoserine101 def: "Protein RLA1_HUMAN with the residue 101 substituted with Phosphoserine" [UniProtKB:P05386] xref: UniProtKB:P05386 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005770 ! RLA1_HUMAN [Term] id: CCO:B0013903 name: RLA1_HUMAN-Phosphoserine104 def: "Protein RLA1_HUMAN with the residue 104 substituted with Phosphoserine" [UniProtKB:P05386] xref: UniProtKB:P05386 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005770 ! RLA1_HUMAN [Term] id: CCO:B0013904 name: RLA2_HUMAN-Phosphoserine17 def: "Protein RLA2_HUMAN with the residue 17 substituted with Phosphoserine" [UniProtKB:P05387] xref: UniProtKB:P05387 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005864 ! RLA2_HUMAN [Term] id: CCO:B0013905 name: RLA2_HUMAN-Phosphoserine102 def: "Protein RLA2_HUMAN with the residue 102 substituted with Phosphoserine" [UniProtKB:P05387] xref: UniProtKB:P05387 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005864 ! RLA2_HUMAN [Term] id: CCO:B0013906 name: RLA2_HUMAN-Phosphoserine105 def: "Protein RLA2_HUMAN with the residue 105 substituted with Phosphoserine" [UniProtKB:P05387] xref: UniProtKB:P05387 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005864 ! RLA2_HUMAN [Term] id: CCO:B0013907 name: RMI1_HUMAN-Phosphoserine292 def: "Protein RMI1_HUMAN with the residue 292 substituted with Phosphoserine" [UniProtKB:Q9H9A7] xref: UniProtKB:Q9H9A7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005919 ! RMI1_HUMAN [Term] id: CCO:B0013908 name: RNC_HUMAN-Phosphoserine284 def: "Protein RNC_HUMAN with the residue 284 substituted with Phosphoserine" [UniProtKB:Q9NRR4] xref: UniProtKB:Q9NRR4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006026 ! RNC_HUMAN [Term] id: CCO:B0013909 name: ROA1_HUMAN-N-acetylserine2 def: "Protein ROA1_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013910 name: ROA1_HUMAN-Phosphoserine4 def: "Protein ROA1_HUMAN with the residue 4 substituted with Phosphoserine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013911 name: ROA1_HUMAN-Phosphoserine6 def: "Protein ROA1_HUMAN with the residue 6 substituted with Phosphoserine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013912 name: ROA1_HUMAN-Phosphoserine91 def: "Protein ROA1_HUMAN with the residue 91 substituted with Phosphoserine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013913 name: ROA1_HUMAN-Phosphoserine95 def: "Protein ROA1_HUMAN with the residue 95 substituted with Phosphoserine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013914 name: ROA1_HUMAN-Phosphothreonine138 def: "Protein ROA1_HUMAN with the residue 138 substituted with Phosphothreonine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013915 name: ROA1_HUMAN-Phosphotyrosine167 def: "Protein ROA1_HUMAN with the residue 167 substituted with Phosphotyrosine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013916 name: ROA1_HUMAN-Omega-N-methylated arginine194 def: "Protein ROA1_HUMAN with the residue 194 substituted with Omega-N-methylated arginine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013917 name: ROA1_HUMAN-Omega-N-methylated arginine206 def: "Protein ROA1_HUMAN with the residue 206 substituted with Omega-N-methylated arginine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013918 name: ROA1_HUMAN-Omega-N-methylated arginine225 def: "Protein ROA1_HUMAN with the residue 225 substituted with Omega-N-methylated arginine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013919 name: ROA1_HUMAN-Phosphoserine311 def: "Protein ROA1_HUMAN with the residue 311 substituted with Phosphoserine" [UniProtKB:P09651] comment: By similarity xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013920 name: ROA1_HUMAN-Phosphoserine338 def: "Protein ROA1_HUMAN with the residue 338 substituted with Phosphoserine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013921 name: ROA1_HUMAN-Phosphotyrosine347 def: "Protein ROA1_HUMAN with the residue 347 substituted with Phosphotyrosine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013922 name: ROA1_HUMAN-N6-acetyllysine350 def: "Protein ROA1_HUMAN with the residue 350 substituted with N6-acetyllysine" [UniProtKB:P09651] xref: UniProtKB:P09651 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005774 ! ROA1_HUMAN [Term] id: CCO:B0013923 name: ROA2_HUMAN-Phosphothreonine176 def: "Protein ROA2_HUMAN with the residue 176 substituted with Phosphothreonine" [UniProtKB:P22626] xref: UniProtKB:P22626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005725 ! ROA2_HUMAN [Term] id: CCO:B0013924 name: ROA2_HUMAN-Omega-N-methylarginine203 def: "Protein ROA2_HUMAN with the residue 203 substituted with Omega-N-methylarginine" [UniProtKB:P22626] xref: UniProtKB:P22626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005725 ! ROA2_HUMAN [Term] id: CCO:B0013925 name: ROA2_HUMAN-Phosphoserine212 def: "Protein ROA2_HUMAN with the residue 212 substituted with Phosphoserine" [UniProtKB:P22626] xref: UniProtKB:P22626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005725 ! ROA2_HUMAN [Term] id: CCO:B0013926 name: ROA2_HUMAN-Phosphoserine259 def: "Protein ROA2_HUMAN with the residue 259 substituted with Phosphoserine" [UniProtKB:P22626] xref: UniProtKB:P22626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005725 ! ROA2_HUMAN [Term] id: CCO:B0013927 name: ROA2_HUMAN-Phosphoserine341 def: "Protein ROA2_HUMAN with the residue 341 substituted with Phosphoserine" [UniProtKB:P22626] xref: UniProtKB:P22626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005725 ! ROA2_HUMAN [Term] id: CCO:B0013928 name: ROA2_HUMAN-Phosphoserine344 def: "Protein ROA2_HUMAN with the residue 344 substituted with Phosphoserine" [UniProtKB:P22626] xref: UniProtKB:P22626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005725 ! ROA2_HUMAN [Term] id: CCO:B0013929 name: ROA2_HUMAN-Phosphotyrosine347 def: "Protein ROA2_HUMAN with the residue 347 substituted with Phosphotyrosine" [UniProtKB:P22626] xref: UniProtKB:P22626 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005725 ! ROA2_HUMAN [Term] id: CCO:B0013930 name: RPAC1_HUMAN-Phosphotyrosine33 def: "Protein RPAC1_HUMAN with the residue 33 substituted with Phosphotyrosine" [UniProtKB:O15160] xref: UniProtKB:O15160 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005246 ! RPAC1_HUMAN [Term] id: CCO:B0013932 name: RS10_HUMAN-Phosphotyrosine12 def: "Protein RS10_HUMAN with the residue 12 substituted with Phosphotyrosine" [UniProtKB:P46783] xref: UniProtKB:P46783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005749 ! RS10_HUMAN [Term] id: CCO:B0013933 name: RS10_HUMAN-Phosphoserine146 def: "Protein RS10_HUMAN with the residue 146 substituted with Phosphoserine" [UniProtKB:P46783] comment: By similarity xref: UniProtKB:P46783 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005749 ! RS10_HUMAN [Term] id: CCO:B0013934 name: RS12_HUMAN-N-acetylalanine2 def: "Protein RS12_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P25398] xref: UniProtKB:P25398 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005767 ! RS12_HUMAN [Term] id: CCO:B0013935 name: RS13_HUMAN-Phosphotyrosine38 def: "Protein RS13_HUMAN with the residue 38 substituted with Phosphotyrosine" [UniProtKB:P62277] xref: UniProtKB:P62277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005748 ! RS13_HUMAN [Term] id: CCO:B0013936 name: RS13_HUMAN-Phosphotyrosine128 def: "Protein RS13_HUMAN with the residue 128 substituted with Phosphotyrosine" [UniProtKB:P62277] xref: UniProtKB:P62277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005748 ! RS13_HUMAN [Term] id: CCO:B0013937 name: RS13_HUMAN-Phosphotyrosine129 def: "Protein RS13_HUMAN with the residue 129 substituted with Phosphotyrosine" [UniProtKB:P62277] xref: UniProtKB:P62277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005748 ! RS13_HUMAN [Term] id: CCO:B0013938 name: RS18_HUMAN-N-acetylserine2 def: "Protein RS18_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P62269] xref: UniProtKB:P62269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005763 ! RS18_HUMAN [Term] id: CCO:B0013939 name: RS20_HUMAN-Phosphothreonine9 def: "Protein RS20_HUMAN with the residue 9 substituted with Phosphothreonine" [UniProtKB:P60866] xref: UniProtKB:P60866 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005563 ! RS20_HUMAN [Term] id: CCO:B0013940 name: RS24_HUMAN-N-acetylmethionine1 def: "Protein RS24_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P62847] xref: UniProtKB:P62847 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005726 ! RS24_HUMAN [Term] id: CCO:B0013941 name: RS3A_HUMAN-Phosphotyrosine256 def: "Protein RS3A_HUMAN with the residue 256 substituted with Phosphotyrosine" [UniProtKB:P61247] xref: UniProtKB:P61247 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005768 ! RS3A_HUMAN [Term] id: CCO:B0013942 name: RS3A_HUMAN-Phosphoserine263 def: "Protein RS3A_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:P61247] xref: UniProtKB:P61247 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005768 ! RS3A_HUMAN [Term] id: CCO:B0013943 name: RS7_HUMAN-N-acetylmethionine1 def: "Protein RS7_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P62081] comment: By similarity xref: UniProtKB:P62081 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005758 ! RS7_HUMAN [Term] id: CCO:B0013944 name: RS8_HUMAN-Phosphoserine160 def: "Protein RS8_HUMAN with the residue 160 substituted with Phosphoserine" [UniProtKB:P62241] comment: By similarity xref: UniProtKB:P62241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005734 ! RS8_HUMAN [Term] id: CCO:B0013945 name: RSSA_HUMAN-N-acetylserine2 def: "Protein RSSA_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P08865] xref: UniProtKB:P08865 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005776 ! RSSA_HUMAN [Term] id: CCO:B0013946 name: RSSA_HUMAN-Phosphotyrosine139 def: "Protein RSSA_HUMAN with the residue 139 substituted with Phosphotyrosine" [UniProtKB:P08865] xref: UniProtKB:P08865 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005776 ! RSSA_HUMAN [Term] id: CCO:B0013947 name: RUVB2_HUMAN-Phosphoserine220 def: "Protein RUVB2_HUMAN with the residue 220 substituted with Phosphoserine" [UniProtKB:Q9Y230] xref: UniProtKB:Q9Y230 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005364 ! RUVB2_HUMAN [Term] id: CCO:B0013948 name: S100B_HUMAN-Blocked amino end (Ser)2 def: "Protein S100B_HUMAN with the residue 2 substituted with Blocked amino end (Ser)" [UniProtKB:P04271] xref: UniProtKB:P04271 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005378 ! S100B_HUMAN [Term] id: CCO:B0013949 name: S10A9_HUMAN-Phosphothreonine113 def: "Protein S10A9_HUMAN with the residue 113 substituted with Phosphothreonine" [UniProtKB:P06702] xref: UniProtKB:P06702 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005461 ! S10A9_HUMAN [Term] id: CCO:B0013950 name: S10AB_HUMAN-Phosphoserine6 def: "Protein S10AB_HUMAN with the residue 6 substituted with Phosphoserine" [UniProtKB:P31949] xref: UniProtKB:P31949 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005825 ! S10AB_HUMAN [Term] id: CCO:B0013952 name: S25BP_HUMAN-Phosphoserine50 def: "Protein S25BP_HUMAN with the residue 50 substituted with Phosphoserine" [UniProtKB:O95295] comment: by PKA; By similarity xref: UniProtKB:O95295 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006234 ! S25BP_HUMAN [Term] id: CCO:B0013953 name: S25BP_HUMAN-Phosphoserine133 def: "Protein S25BP_HUMAN with the residue 133 substituted with Phosphoserine" [UniProtKB:O95295] xref: UniProtKB:O95295 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006234 ! S25BP_HUMAN [Term] id: CCO:B0013954 name: SAC31_HUMAN-Phosphoserine401 def: "Protein SAC31_HUMAN with the residue 401 substituted with Phosphoserine" [UniProtKB:A6NKF1] xref: UniProtKB:A6NKF1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000388 ! spindle relationship: transformation_of CCO:B0001334 ! SAC31_HUMAN [Term] id: CCO:B0013956 name: SAE1_HUMAN-Phosphoserine185 def: "Protein SAE1_HUMAN with the residue 185 substituted with Phosphoserine" [UniProtKB:Q9UBE0] xref: UniProtKB:Q9UBE0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006046 ! SAE1_HUMAN [Term] id: CCO:B0013961 name: SASH1_HUMAN-Phosphoserine90 def: "Protein SASH1_HUMAN with the residue 90 substituted with Phosphoserine" [UniProtKB:O94885] xref: UniProtKB:O94885 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001444 ! SASH1_HUMAN [Term] id: CCO:B0013962 name: SASH1_HUMAN-Phosphoserine731 def: "Protein SASH1_HUMAN with the residue 731 substituted with Phosphoserine" [UniProtKB:O94885] comment: By similarity xref: UniProtKB:O94885 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001444 ! SASH1_HUMAN [Term] id: CCO:B0013963 name: SASH1_HUMAN-Phosphoserine821 def: "Protein SASH1_HUMAN with the residue 821 substituted with Phosphoserine" [UniProtKB:O94885] comment: By similarity xref: UniProtKB:O94885 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001444 ! SASH1_HUMAN [Term] id: CCO:B0013964 name: SASH1_HUMAN-Phosphoserine839 def: "Protein SASH1_HUMAN with the residue 839 substituted with Phosphoserine" [UniProtKB:O94885] comment: By similarity xref: UniProtKB:O94885 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001444 ! SASH1_HUMAN [Term] id: CCO:B0013965 name: SBP1_HUMAN-Phosphoserine467 def: "Protein SBP1_HUMAN with the residue 467 substituted with Phosphoserine" [UniProtKB:Q13228] comment: By similarity xref: UniProtKB:Q13228 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006083 ! SBP1_HUMAN [Term] id: CCO:B0013966 name: SCFD1_HUMAN-Phosphoserine57 def: "Protein SCFD1_HUMAN with the residue 57 substituted with Phosphoserine" [UniProtKB:Q8WVM8] xref: UniProtKB:Q8WVM8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006349 ! SCFD1_HUMAN [Term] id: CCO:B0013967 name: SCFD1_HUMAN-Phosphoserine528 def: "Protein SCFD1_HUMAN with the residue 528 substituted with Phosphoserine" [UniProtKB:Q8WVM8] xref: UniProtKB:Q8WVM8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006349 ! SCFD1_HUMAN [Term] id: CCO:B0013968 name: SCG1_HUMAN-Phosphoserine149 def: "Protein SCG1_HUMAN with the residue 149 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013969 name: SCG1_HUMAN-N6-acetyllysine153 def: "Protein SCG1_HUMAN with the residue 153 substituted with N6-acetyllysine" [UniProtKB:P05060] comment: By similarity xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013971 name: SCG1_HUMAN-Phosphoserine182 def: "Protein SCG1_HUMAN with the residue 182 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013972 name: SCG1_HUMAN-Phosphoserine183 def: "Protein SCG1_HUMAN with the residue 183 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013973 name: SCG1_HUMAN-Phosphoserine259 def: "Protein SCG1_HUMAN with the residue 259 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013974 name: SCG1_HUMAN-Phosphoserine263 def: "Protein SCG1_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013975 name: SCG1_HUMAN-Phosphoserine311 def: "Protein SCG1_HUMAN with the residue 311 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013976 name: SCG1_HUMAN-Phosphoserine335 def: "Protein SCG1_HUMAN with the residue 335 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013977 name: SCG1_HUMAN-Sulfotyrosine341 def: "Protein SCG1_HUMAN with the residue 341 substituted with Sulfotyrosine" [UniProtKB:P05060] comment: By similarity xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013978 name: SCG1_HUMAN-Phosphoserine377 def: "Protein SCG1_HUMAN with the residue 377 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013979 name: SCG1_HUMAN-Phosphoserine405 def: "Protein SCG1_HUMAN with the residue 405 substituted with Phosphoserine" [UniProtKB:P05060] comment: Potential xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013980 name: SCG1_HUMAN-Phosphoserine617 def: "Protein SCG1_HUMAN with the residue 617 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013981 name: SCG1_HUMAN-Phosphoserine626 def: "Protein SCG1_HUMAN with the residue 626 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0013982 name: SDS3_HUMAN-Phosphoserine45 def: "Protein SDS3_HUMAN with the residue 45 substituted with Phosphoserine" [UniProtKB:Q9H7L9] xref: UniProtKB:Q9H7L9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005694 ! SDS3_HUMAN [Term] id: CCO:B0013983 name: SDS3_HUMAN-Phosphothreonine49 def: "Protein SDS3_HUMAN with the residue 49 substituted with Phosphothreonine" [UniProtKB:Q9H7L9] xref: UniProtKB:Q9H7L9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005694 ! SDS3_HUMAN [Term] id: CCO:B0013984 name: SDS3_HUMAN-Phosphothreonine55 def: "Protein SDS3_HUMAN with the residue 55 substituted with Phosphothreonine" [UniProtKB:Q9H7L9] xref: UniProtKB:Q9H7L9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005694 ! SDS3_HUMAN [Term] id: CCO:B0013985 name: SDS3_HUMAN-Phosphoserine234 def: "Protein SDS3_HUMAN with the residue 234 substituted with Phosphoserine" [UniProtKB:Q9H7L9] xref: UniProtKB:Q9H7L9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005694 ! SDS3_HUMAN [Term] id: CCO:B0013986 name: SDS3_HUMAN-Phosphoserine236 def: "Protein SDS3_HUMAN with the residue 236 substituted with Phosphoserine" [UniProtKB:Q9H7L9] xref: UniProtKB:Q9H7L9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005694 ! SDS3_HUMAN [Term] id: CCO:B0013987 name: SDS3_HUMAN-Phosphothreonine244 def: "Protein SDS3_HUMAN with the residue 244 substituted with Phosphothreonine" [UniProtKB:Q9H7L9] xref: UniProtKB:Q9H7L9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005694 ! SDS3_HUMAN [Term] id: CCO:B0013988 name: SENP7_HUMAN-Phosphoserine377 def: "Protein SENP7_HUMAN with the residue 377 substituted with Phosphoserine" [UniProtKB:Q9BQF6] xref: UniProtKB:Q9BQF6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006018 ! SENP7_HUMAN [Term] id: CCO:B0013989 name: SENP7_HUMAN-Phosphoserine378 def: "Protein SENP7_HUMAN with the residue 378 substituted with Phosphoserine" [UniProtKB:Q9BQF6] xref: UniProtKB:Q9BQF6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006018 ! SENP7_HUMAN [Term] id: CCO:B0013990 name: SEP11_HUMAN-N-acetylalanine2 def: "Protein SEP11_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9NVA2] xref: UniProtKB:Q9NVA2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002169 ! SEP11_HUMAN [Term] id: CCO:B0013991 name: SEPT2_HUMAN-Phosphotyrosine17 def: "Protein SEPT2_HUMAN with the residue 17 substituted with Phosphotyrosine" [UniProtKB:Q15019] xref: UniProtKB:Q15019 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0001135 ! septin complex relationship: transformation_of CCO:B0001800 ! SEPT2_HUMAN [Term] id: CCO:B0013992 name: SEPT2_HUMAN-Phosphoserine218 def: "Protein SEPT2_HUMAN with the residue 218 substituted with Phosphoserine" [UniProtKB:Q15019] xref: UniProtKB:Q15019 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001800 ! SEPT2_HUMAN [Term] id: CCO:B0013993 name: SEPT2_HUMAN-Phosphothreonine228 def: "Protein SEPT2_HUMAN with the residue 228 substituted with Phosphothreonine" [UniProtKB:Q15019] comment: By similarity xref: UniProtKB:Q15019 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001800 ! SEPT2_HUMAN [Term] id: CCO:B0013994 name: SEPT3_HUMAN-Phosphoserine91 def: "Protein SEPT3_HUMAN with the residue 91 substituted with Phosphoserine" [UniProtKB:Q9UH03] comment: By similarity xref: UniProtKB:Q9UH03 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002198 ! SEPT3_HUMAN [Term] id: CCO:B0013995 name: SEPT4_HUMAN-Phosphoserine325 def: "Protein SEPT4_HUMAN with the residue 325 substituted with Phosphoserine" [UniProtKB:O43236] comment: By similarity xref: UniProtKB:O43236 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001382 ! SEPT4_HUMAN [Term] id: CCO:B0013996 name: SEPT5_HUMAN-Phosphoserine327 def: "Protein SEPT5_HUMAN with the residue 327 substituted with Phosphoserine" [UniProtKB:Q99719] comment: By similarity xref: UniProtKB:Q99719 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002085 ! SEPT5_HUMAN [Term] id: CCO:B0013997 name: SEPT5_HUMAN-Phosphothreonine336 def: "Protein SEPT5_HUMAN with the residue 336 substituted with Phosphothreonine" [UniProtKB:Q99719] comment: By similarity xref: UniProtKB:Q99719 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002085 ! SEPT5_HUMAN [Term] id: CCO:B0013998 name: SEPT6_HUMAN-N-acetylalanine2 def: "Protein SEPT6_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q14141] xref: UniProtKB:Q14141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001775 ! SEPT6_HUMAN [Term] id: CCO:B0013999 name: SEPT6_HUMAN-Phosphoserine408 def: "Protein SEPT6_HUMAN with the residue 408 substituted with Phosphoserine" [UniProtKB:Q14141] xref: UniProtKB:Q14141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001775 ! SEPT6_HUMAN [Term] id: CCO:B0014000 name: SEPT6_HUMAN-Phosphoserine411 def: "Protein SEPT6_HUMAN with the residue 411 substituted with Phosphoserine" [UniProtKB:Q14141] xref: UniProtKB:Q14141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001775 ! SEPT6_HUMAN [Term] id: CCO:B0014001 name: SEPT6_HUMAN-Phosphoserine416 def: "Protein SEPT6_HUMAN with the residue 416 substituted with Phosphoserine" [UniProtKB:Q14141] xref: UniProtKB:Q14141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001775 ! SEPT6_HUMAN [Term] id: CCO:B0014002 name: SEPT6_HUMAN-Phosphothreonine418 def: "Protein SEPT6_HUMAN with the residue 418 substituted with Phosphothreonine" [UniProtKB:Q14141] xref: UniProtKB:Q14141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001775 ! SEPT6_HUMAN [Term] id: CCO:B0014003 name: SEPT7_HUMAN-Phosphothreonine228 def: "Protein SEPT7_HUMAN with the residue 228 substituted with Phosphothreonine" [UniProtKB:Q16181] comment: By similarity xref: UniProtKB:Q16181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001816 ! SEPT7_HUMAN [Term] id: CCO:B0014004 name: SEPT7_HUMAN-Phosphotyrosine319 def: "Protein SEPT7_HUMAN with the residue 319 substituted with Phosphotyrosine" [UniProtKB:Q16181] xref: UniProtKB:Q16181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001816 ! SEPT7_HUMAN [Term] id: CCO:B0014005 name: SEPT7_HUMAN-Phosphoserine334 def: "Protein SEPT7_HUMAN with the residue 334 substituted with Phosphoserine" [UniProtKB:Q16181] xref: UniProtKB:Q16181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001816 ! SEPT7_HUMAN [Term] id: CCO:B0014006 name: SEPT7_HUMAN-Phosphoserine423 def: "Protein SEPT7_HUMAN with the residue 423 substituted with Phosphoserine" [UniProtKB:Q16181] xref: UniProtKB:Q16181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001484 ! structural molecule activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000180 ! stress fiber relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0001135 ! septin complex relationship: transformation_of CCO:B0001816 ! SEPT7_HUMAN [Term] id: CCO:B0014007 name: SEPT7_HUMAN-Phosphothreonine426 def: "Protein SEPT7_HUMAN with the residue 426 substituted with Phosphothreonine" [UniProtKB:Q16181] xref: UniProtKB:Q16181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001816 ! SEPT7_HUMAN [Term] id: CCO:B0014008 name: SEPT8_HUMAN-N-acetylalanine2 def: "Protein SEPT8_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q92599] comment: By similarity xref: UniProtKB:Q92599 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002015 ! SEPT8_HUMAN [Term] id: CCO:B0014009 name: SEPT8_HUMAN-Phosphoserine10 def: "Protein SEPT8_HUMAN with the residue 10 substituted with Phosphoserine" [UniProtKB:Q92599] comment: By similarity xref: UniProtKB:Q92599 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002015 ! SEPT8_HUMAN [Term] id: CCO:B0014010 name: SEPT9_HUMAN-Phosphoserine30 def: "Protein SEPT9_HUMAN with the residue 30 substituted with Phosphoserine" [UniProtKB:Q9UHD8] xref: UniProtKB:Q9UHD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002201 ! SEPT9_HUMAN [Term] id: CCO:B0014011 name: SEPT9_HUMAN-Phosphothreonine42 def: "Protein SEPT9_HUMAN with the residue 42 substituted with Phosphothreonine" [UniProtKB:Q9UHD8] xref: UniProtKB:Q9UHD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002201 ! SEPT9_HUMAN [Term] id: CCO:B0014012 name: SEPT9_HUMAN-Phosphothreonine49 def: "Protein SEPT9_HUMAN with the residue 49 substituted with Phosphothreonine" [UniProtKB:Q9UHD8] comment: By similarity xref: UniProtKB:Q9UHD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002201 ! SEPT9_HUMAN [Term] id: CCO:B0014013 name: SEPT9_HUMAN-Phosphoserine82 def: "Protein SEPT9_HUMAN with the residue 82 substituted with Phosphoserine" [UniProtKB:Q9UHD8] xref: UniProtKB:Q9UHD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002201 ! SEPT9_HUMAN [Term] id: CCO:B0014014 name: SEPT9_HUMAN-Phosphoserine85 def: "Protein SEPT9_HUMAN with the residue 85 substituted with Phosphoserine" [UniProtKB:Q9UHD8] xref: UniProtKB:Q9UHD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002201 ! SEPT9_HUMAN [Term] id: CCO:B0014015 name: SEPT9_HUMAN-Phosphoserine89 def: "Protein SEPT9_HUMAN with the residue 89 substituted with Phosphoserine" [UniProtKB:Q9UHD8] xref: UniProtKB:Q9UHD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002201 ! SEPT9_HUMAN [Term] id: CCO:B0014016 name: SEPT9_HUMAN-Phosphothreonine142 def: "Protein SEPT9_HUMAN with the residue 142 substituted with Phosphothreonine" [UniProtKB:Q9UHD8] xref: UniProtKB:Q9UHD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002201 ! SEPT9_HUMAN [Term] id: CCO:B0014017 name: SESN1_HUMAN-Phosphoserine293 def: "Protein SESN1_HUMAN with the residue 293 substituted with Phosphoserine" [UniProtKB:Q9Y6P5] xref: UniProtKB:Q9Y6P5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002266 ! SESN1_HUMAN [Term] id: CCO:B0014018 name: SET1A_HUMAN-Phosphoserine468 def: "Protein SET1A_HUMAN with the residue 468 substituted with Phosphoserine" [UniProtKB:O15047] xref: UniProtKB:O15047 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005613 ! SET1A_HUMAN [Term] id: CCO:B0014019 name: SET1A_HUMAN-Phosphoserine470 def: "Protein SET1A_HUMAN with the residue 470 substituted with Phosphoserine" [UniProtKB:O15047] xref: UniProtKB:O15047 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005613 ! SET1A_HUMAN [Term] id: CCO:B0014020 name: SETB1_HUMAN-Phosphothreonine838 def: "Protein SETB1_HUMAN with the residue 838 substituted with Phosphothreonine" [UniProtKB:Q15047] xref: UniProtKB:Q15047 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:B0014021 name: SETB1_HUMAN-Phosphoserine1179 def: "Protein SETB1_HUMAN with the residue 1179 substituted with Phosphoserine" [UniProtKB:Q15047] xref: UniProtKB:Q15047 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:B0014022 name: SETB1_HUMAN-Phosphothreonine1180 def: "Protein SETB1_HUMAN with the residue 1180 substituted with Phosphothreonine" [UniProtKB:Q15047] xref: UniProtKB:Q15047 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:B0014023 name: SETB1_HUMAN-Phosphoserine1190 def: "Protein SETB1_HUMAN with the residue 1190 substituted with Phosphoserine" [UniProtKB:Q15047] xref: UniProtKB:Q15047 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:B0014024 name: SET_HUMAN-Phosphoserine7 def: "Protein SET_HUMAN with the residue 7 substituted with Phosphoserine" [UniProtKB:Q01105] xref: UniProtKB:Q01105 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005519 ! SET_HUMAN [Term] id: CCO:B0014025 name: SET_HUMAN-Phosphoserine30 def: "Protein SET_HUMAN with the residue 30 substituted with Phosphoserine" [UniProtKB:Q01105] comment: By similarity xref: UniProtKB:Q01105 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005519 ! SET_HUMAN [Term] id: CCO:B0014042 name: SGOL2_HUMAN-Phosphoserine266 def: "Protein SGOL2_HUMAN with the residue 266 substituted with Phosphoserine" [UniProtKB:Q562F6] xref: UniProtKB:Q562F6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001840 ! SGOL2_HUMAN [Term] id: CCO:B0014043 name: SGOL2_HUMAN-Phosphoserine507 def: "Protein SGOL2_HUMAN with the residue 507 substituted with Phosphoserine" [UniProtKB:Q562F6] xref: UniProtKB:Q562F6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001840 ! SGOL2_HUMAN [Term] id: CCO:B0014044 name: SGOL2_HUMAN-Phosphothreonine845 def: "Protein SGOL2_HUMAN with the residue 845 substituted with Phosphothreonine" [UniProtKB:Q562F6] xref: UniProtKB:Q562F6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001840 ! SGOL2_HUMAN [Term] id: CCO:B0014052 name: SH3B4_HUMAN-Phosphoserine637 def: "Protein SH3B4_HUMAN with the residue 637 substituted with Phosphoserine" [UniProtKB:Q9P0V3] xref: UniProtKB:Q9P0V3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002182 ! SH3B4_HUMAN [Term] id: CCO:B0014053 name: SH3G1_HUMAN-Phosphoserine288 def: "Protein SH3G1_HUMAN with the residue 288 substituted with Phosphoserine" [UniProtKB:Q99961] xref: UniProtKB:Q99961 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006310 ! SH3G1_HUMAN [Term] id: CCO:B0014054 name: SH3G2_HUMAN-Phosphoserine75 def: "Protein SH3G2_HUMAN with the residue 75 substituted with Phosphoserine" [UniProtKB:Q99962] xref: UniProtKB:Q99962 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006188 ! SH3G2_HUMAN [Term] id: CCO:B0014055 name: SHC1_HUMAN-Phosphoserine36 def: "Protein SHC1_HUMAN with the residue 36 substituted with Phosphoserine" [UniProtKB:P29353] comment: By similarity xref: UniProtKB:P29353 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001569 ! SHC1_HUMAN [Term] id: CCO:B0014056 name: SHC1_HUMAN-Phosphoserine139 def: "Protein SHC1_HUMAN with the residue 139 substituted with Phosphoserine" [UniProtKB:P29353] xref: UniProtKB:P29353 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001569 ! SHC1_HUMAN [Term] id: CCO:B0014057 name: SHC1_HUMAN-Phosphotyrosine349 def: "Protein SHC1_HUMAN with the residue 349 substituted with Phosphotyrosine" [UniProtKB:P29353] xref: UniProtKB:P29353 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001569 ! SHC1_HUMAN [Term] id: CCO:B0014058 name: SHC1_HUMAN-Phosphotyrosine350 def: "Protein SHC1_HUMAN with the residue 350 substituted with Phosphotyrosine" [UniProtKB:P29353] xref: UniProtKB:P29353 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001569 ! SHC1_HUMAN [Term] id: CCO:B0014059 name: SHC1_HUMAN-Phosphotyrosine427 def: "Protein SHC1_HUMAN with the residue 427 substituted with Phosphotyrosine" [UniProtKB:P29353] xref: UniProtKB:P29353 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001569 ! SHC1_HUMAN [Term] id: CCO:B0014060 name: SIN3A_HUMAN-Phosphoserine832 def: "Protein SIN3A_HUMAN with the residue 832 substituted with Phosphoserine" [UniProtKB:Q96ST3] xref: UniProtKB:Q96ST3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:B0014061 name: SIN3A_HUMAN-Phosphoserine860 def: "Protein SIN3A_HUMAN with the residue 860 substituted with Phosphoserine" [UniProtKB:Q96ST3] xref: UniProtKB:Q96ST3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:B0014062 name: SIN3A_HUMAN-Phosphoserine1112 def: "Protein SIN3A_HUMAN with the residue 1112 substituted with Phosphoserine" [UniProtKB:Q96ST3] xref: UniProtKB:Q96ST3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:B0014063 name: SIPA1_HUMAN-Phosphoserine74 def: "Protein SIPA1_HUMAN with the residue 74 substituted with Phosphoserine" [UniProtKB:Q96FS4] xref: UniProtKB:Q96FS4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002039 ! SIPA1_HUMAN [Term] id: CCO:B0014064 name: SKIV2_HUMAN-Phosphoserine245 def: "Protein SKIV2_HUMAN with the residue 245 substituted with Phosphoserine" [UniProtKB:Q15477] xref: UniProtKB:Q15477 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005565 ! SKIV2_HUMAN [Term] id: CCO:B0014065 name: SKIV2_HUMAN-Phosphoserine256 def: "Protein SKIV2_HUMAN with the residue 256 substituted with Phosphoserine" [UniProtKB:Q15477] xref: UniProtKB:Q15477 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005565 ! SKIV2_HUMAN [Term] id: CCO:B0014066 name: SKIV2_HUMAN-Phosphoserine366 def: "Protein SKIV2_HUMAN with the residue 366 substituted with Phosphoserine" [UniProtKB:Q15477] xref: UniProtKB:Q15477 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005565 ! SKIV2_HUMAN [Term] id: CCO:B0014067 name: SKP2_HUMAN-Phosphoserine64 def: "Protein SKP2_HUMAN with the residue 64 substituted with Phosphoserine" [UniProtKB:Q13309] xref: UniProtKB:Q13309 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001749 ! SKP2_HUMAN [Term] id: CCO:B0014068 name: SMC1A_HUMAN-Phosphoserine358 def: "Protein SMC1A_HUMAN with the residue 358 substituted with Phosphoserine" [UniProtKB:Q14683] xref: UniProtKB:Q14683 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:B0014069 name: SMC1A_HUMAN-Phosphoserine360 def: "Protein SMC1A_HUMAN with the residue 360 substituted with Phosphoserine" [UniProtKB:Q14683] xref: UniProtKB:Q14683 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:B0014070 name: SMC1A_HUMAN-Phosphoserine951 def: "Protein SMC1A_HUMAN with the residue 951 substituted with Phosphoserine" [UniProtKB:Q14683] xref: UniProtKB:Q14683 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:B0014071 name: SMC1A_HUMAN-Phosphoserine957 def: "Protein SMC1A_HUMAN with the residue 957 substituted with Phosphoserine" [UniProtKB:Q14683] comment: by ATM; xref: UniProtKB:Q14683 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:B0014072 name: SMC1A_HUMAN-Phosphoserine962 def: "Protein SMC1A_HUMAN with the residue 962 substituted with Phosphoserine" [UniProtKB:Q14683] xref: UniProtKB:Q14683 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:B0014073 name: SMC1A_HUMAN-Phosphoserine966 def: "Protein SMC1A_HUMAN with the residue 966 substituted with Phosphoserine" [UniProtKB:Q14683] comment: by ATM and ATR; xref: UniProtKB:Q14683 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:B0014074 name: SMC1B_HUMAN-Phosphoserine882 def: "Protein SMC1B_HUMAN with the residue 882 substituted with Phosphoserine" [UniProtKB:Q8NDV3] xref: UniProtKB:Q8NDV3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001977 ! SMC1B_HUMAN [Term] id: CCO:B0014075 name: SMC1B_HUMAN-Phosphoserine883 def: "Protein SMC1B_HUMAN with the residue 883 substituted with Phosphoserine" [UniProtKB:Q8NDV3] xref: UniProtKB:Q8NDV3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003445 ! ATPase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000296 ! chromosome relationship: transformation_of CCO:B0001977 ! SMC1B_HUMAN [Term] id: CCO:B0014076 name: SMC3_HUMAN-Phosphoserine787 def: "Protein SMC3_HUMAN with the residue 787 substituted with Phosphoserine" [UniProtKB:Q9UQE7] xref: UniProtKB:Q9UQE7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002243 ! SMC3_HUMAN [Term] id: CCO:B0014077 name: SMC3_HUMAN-Phosphoserine1013 def: "Protein SMC3_HUMAN with the residue 1013 substituted with Phosphoserine" [UniProtKB:Q9UQE7] comment: By similarity xref: UniProtKB:Q9UQE7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002243 ! SMC3_HUMAN [Term] id: CCO:B0014078 name: SMC3_HUMAN-Phosphoserine1065 def: "Protein SMC3_HUMAN with the residue 1065 substituted with Phosphoserine" [UniProtKB:Q9UQE7] xref: UniProtKB:Q9UQE7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002243 ! SMC3_HUMAN [Term] id: CCO:B0014079 name: SMC3_HUMAN-Phosphoserine1067 def: "Protein SMC3_HUMAN with the residue 1067 substituted with Phosphoserine" [UniProtKB:Q9UQE7] xref: UniProtKB:Q9UQE7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002243 ! SMC3_HUMAN [Term] id: CCO:B0014080 name: SMC3_HUMAN-Phosphoserine1074 def: "Protein SMC3_HUMAN with the residue 1074 substituted with Phosphoserine" [UniProtKB:Q9UQE7] xref: UniProtKB:Q9UQE7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002243 ! SMC3_HUMAN [Term] id: CCO:B0014081 name: SMC3_HUMAN-Phosphoserine1083 def: "Protein SMC3_HUMAN with the residue 1083 substituted with Phosphoserine" [UniProtKB:Q9UQE7] xref: UniProtKB:Q9UQE7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002243 ! SMC3_HUMAN [Term] id: CCO:B0014082 name: SMC4_HUMAN-Phosphoserine22 def: "Protein SMC4_HUMAN with the residue 22 substituted with Phosphoserine" [UniProtKB:Q9NTJ3] xref: UniProtKB:Q9NTJ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002168 ! SMC4_HUMAN [Term] id: CCO:B0014083 name: SMC4_HUMAN-Phosphoserine28 def: "Protein SMC4_HUMAN with the residue 28 substituted with Phosphoserine" [UniProtKB:Q9NTJ3] xref: UniProtKB:Q9NTJ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002168 ! SMC4_HUMAN [Term] id: CCO:B0014084 name: SMC4_HUMAN-Phosphoserine41 def: "Protein SMC4_HUMAN with the residue 41 substituted with Phosphoserine" [UniProtKB:Q9NTJ3] xref: UniProtKB:Q9NTJ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0006299 ! protein heterodimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000123 ! condensin complex relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000296 ! chromosome relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0002168 ! SMC4_HUMAN [Term] id: CCO:B0014085 name: SMC4_HUMAN-Phosphoserine1056 def: "Protein SMC4_HUMAN with the residue 1056 substituted with Phosphoserine" [UniProtKB:Q9NTJ3] xref: UniProtKB:Q9NTJ3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002168 ! SMC4_HUMAN [Term] id: CCO:B0014086 name: SMCA2_HUMAN-Phosphoserine325 def: "Protein SMCA2_HUMAN with the residue 325 substituted with Phosphoserine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014087 name: SMCA2_HUMAN-Phosphoserine587 def: "Protein SMCA2_HUMAN with the residue 587 substituted with Phosphoserine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014088 name: SMCA2_HUMAN-Phosphoserine952 def: "Protein SMCA2_HUMAN with the residue 952 substituted with Phosphoserine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014089 name: SMCA2_HUMAN-Phosphoserine1373 def: "Protein SMCA2_HUMAN with the residue 1373 substituted with Phosphoserine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014090 name: SMCA2_HUMAN-Phosphoserine1406 def: "Protein SMCA2_HUMAN with the residue 1406 substituted with Phosphoserine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014091 name: SMCA2_HUMAN-Phosphoserine1414 def: "Protein SMCA2_HUMAN with the residue 1414 substituted with Phosphoserine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014092 name: SMCA2_HUMAN-Phosphoserine1415 def: "Protein SMCA2_HUMAN with the residue 1415 substituted with Phosphoserine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014093 name: SMCA2_HUMAN-N6-acetyllysine1547 def: "Protein SMCA2_HUMAN with the residue 1547 substituted with N6-acetyllysine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014094 name: SMCA2_HUMAN-N6-acetyllysine1549 def: "Protein SMCA2_HUMAN with the residue 1549 substituted with N6-acetyllysine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014095 name: SMCA2_HUMAN-N6-acetyllysine1551 def: "Protein SMCA2_HUMAN with the residue 1551 substituted with N6-acetyllysine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014096 name: SMCA2_HUMAN-Phosphoserine1564 def: "Protein SMCA2_HUMAN with the residue 1564 substituted with Phosphoserine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014097 name: SMCA2_HUMAN-Phosphoserine1568 def: "Protein SMCA2_HUMAN with the residue 1568 substituted with Phosphoserine" [UniProtKB:P51531] xref: UniProtKB:P51531 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:B0014098 name: SMCA4_HUMAN-Phosphothreonine11 def: "Protein SMCA4_HUMAN with the residue 11 substituted with Phosphothreonine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014099 name: SMCA4_HUMAN-Phosphoserine610 def: "Protein SMCA4_HUMAN with the residue 610 substituted with Phosphoserine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014100 name: SMCA4_HUMAN-Phosphoserine655 def: "Protein SMCA4_HUMAN with the residue 655 substituted with Phosphoserine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014101 name: SMCA4_HUMAN-Phosphoserine657 def: "Protein SMCA4_HUMAN with the residue 657 substituted with Phosphoserine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014102 name: SMCA4_HUMAN-Phosphoserine660 def: "Protein SMCA4_HUMAN with the residue 660 substituted with Phosphoserine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014103 name: SMCA4_HUMAN-Phosphoserine662 def: "Protein SMCA4_HUMAN with the residue 662 substituted with Phosphoserine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014104 name: SMCA4_HUMAN-Phosphoserine695 def: "Protein SMCA4_HUMAN with the residue 695 substituted with Phosphoserine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014105 name: SMCA4_HUMAN-Phosphoserine721 def: "Protein SMCA4_HUMAN with the residue 721 substituted with Phosphoserine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014106 name: SMCA4_HUMAN-Phosphoserine1382 def: "Protein SMCA4_HUMAN with the residue 1382 substituted with Phosphoserine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014107 name: SMCA4_HUMAN-Phosphoserine1452 def: "Protein SMCA4_HUMAN with the residue 1452 substituted with Phosphoserine" [UniProtKB:P51532] xref: UniProtKB:P51532 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:B0014108 name: SMN_HUMAN-Phosphoserine4 def: "Protein SMN_HUMAN with the residue 4 substituted with Phosphoserine" [UniProtKB:Q16637] xref: UniProtKB:Q16637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006110 ! SMN_HUMAN [Term] id: CCO:B0014109 name: SMN_HUMAN-Phosphoserine5 def: "Protein SMN_HUMAN with the residue 5 substituted with Phosphoserine" [UniProtKB:Q16637] xref: UniProtKB:Q16637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006110 ! SMN_HUMAN [Term] id: CCO:B0014110 name: SMN_HUMAN-Phosphoserine8 def: "Protein SMN_HUMAN with the residue 8 substituted with Phosphoserine" [UniProtKB:Q16637] xref: UniProtKB:Q16637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006110 ! SMN_HUMAN [Term] id: CCO:B0014111 name: SMN_HUMAN-Phosphoserine28 def: "Protein SMN_HUMAN with the residue 28 substituted with Phosphoserine" [UniProtKB:Q16637] xref: UniProtKB:Q16637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006110 ! SMN_HUMAN [Term] id: CCO:B0014112 name: SMN_HUMAN-Phosphoserine31 def: "Protein SMN_HUMAN with the residue 31 substituted with Phosphoserine" [UniProtKB:Q16637] xref: UniProtKB:Q16637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006110 ! SMN_HUMAN [Term] id: CCO:B0014113 name: SMRC1_HUMAN-Phosphoserine310 def: "Protein SMRC1_HUMAN with the residue 310 substituted with Phosphoserine" [UniProtKB:Q92922] xref: UniProtKB:Q92922 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005418 ! SMRC1_HUMAN [Term] id: CCO:B0014114 name: SMRC1_HUMAN-Phosphoserine319 def: "Protein SMRC1_HUMAN with the residue 319 substituted with Phosphoserine" [UniProtKB:Q92922] xref: UniProtKB:Q92922 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005418 ! SMRC1_HUMAN [Term] id: CCO:B0014115 name: SMRC1_HUMAN-Phosphoserine328 def: "Protein SMRC1_HUMAN with the residue 328 substituted with Phosphoserine" [UniProtKB:Q92922] xref: UniProtKB:Q92922 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005418 ! SMRC1_HUMAN [Term] id: CCO:B0014116 name: SMRC1_HUMAN-Phosphoserine330 def: "Protein SMRC1_HUMAN with the residue 330 substituted with Phosphoserine" [UniProtKB:Q92922] xref: UniProtKB:Q92922 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005418 ! SMRC1_HUMAN [Term] id: CCO:B0014117 name: SMRC1_HUMAN-Phosphothreonine335 def: "Protein SMRC1_HUMAN with the residue 335 substituted with Phosphothreonine" [UniProtKB:Q92922] xref: UniProtKB:Q92922 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005418 ! SMRC1_HUMAN [Term] id: CCO:B0014118 name: SMRC1_HUMAN-Phosphothreonine337 def: "Protein SMRC1_HUMAN with the residue 337 substituted with Phosphothreonine" [UniProtKB:Q92922] xref: UniProtKB:Q92922 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005418 ! SMRC1_HUMAN [Term] id: CCO:B0014119 name: SMRC1_HUMAN-Phosphoserine357 def: "Protein SMRC1_HUMAN with the residue 357 substituted with Phosphoserine" [UniProtKB:Q92922] xref: UniProtKB:Q92922 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005418 ! SMRC1_HUMAN [Term] id: CCO:B0014120 name: SMRC2_HUMAN-Phosphoserine283 def: "Protein SMRC2_HUMAN with the residue 283 substituted with Phosphoserine" [UniProtKB:Q8TAQ2] comment: By similarity xref: UniProtKB:Q8TAQ2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005417 ! SMRC2_HUMAN [Term] id: CCO:B0014121 name: SMRC2_HUMAN-Phosphotyrosine296 def: "Protein SMRC2_HUMAN with the residue 296 substituted with Phosphotyrosine" [UniProtKB:Q8TAQ2] xref: UniProtKB:Q8TAQ2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005417 ! SMRC2_HUMAN [Term] id: CCO:B0014122 name: SMRC2_HUMAN-Phosphoserine302 def: "Protein SMRC2_HUMAN with the residue 302 substituted with Phosphoserine" [UniProtKB:Q8TAQ2] xref: UniProtKB:Q8TAQ2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005417 ! SMRC2_HUMAN [Term] id: CCO:B0014123 name: SMRC2_HUMAN-Phosphoserine304 def: "Protein SMRC2_HUMAN with the residue 304 substituted with Phosphoserine" [UniProtKB:Q8TAQ2] xref: UniProtKB:Q8TAQ2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005417 ! SMRC2_HUMAN [Term] id: CCO:B0014124 name: SMRC2_HUMAN-Phosphothreonine322 def: "Protein SMRC2_HUMAN with the residue 322 substituted with Phosphothreonine" [UniProtKB:Q8TAQ2] xref: UniProtKB:Q8TAQ2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005417 ! SMRC2_HUMAN [Term] id: CCO:B0014125 name: SMRC2_HUMAN-Phosphoserine347 def: "Protein SMRC2_HUMAN with the residue 347 substituted with Phosphoserine" [UniProtKB:Q8TAQ2] xref: UniProtKB:Q8TAQ2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005417 ! SMRC2_HUMAN [Term] id: CCO:B0014126 name: SMRD2_HUMAN-Phosphothreonine142 def: "Protein SMRD2_HUMAN with the residue 142 substituted with Phosphothreonine" [UniProtKB:Q92925] xref: UniProtKB:Q92925 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005419 ! SMRD2_HUMAN [Term] id: CCO:B0014127 name: SMRD2_HUMAN-Phosphothreonine408 def: "Protein SMRD2_HUMAN with the residue 408 substituted with Phosphothreonine" [UniProtKB:Q92925] xref: UniProtKB:Q92925 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005419 ! SMRD2_HUMAN [Term] id: CCO:B0014128 name: SN1L1_HUMAN-Phosphothreonine182 def: "Protein SN1L1_HUMAN with the residue 182 substituted with Phosphothreonine" [UniProtKB:P57059] xref: UniProtKB:P57059 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001680 ! SN1L1_HUMAN [Term] id: CCO:B0014129 name: SN1L1_HUMAN-Phosphoserine186 def: "Protein SN1L1_HUMAN with the residue 186 substituted with Phosphoserine" [UniProtKB:P57059] comment: By similarity xref: UniProtKB:P57059 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001680 ! SN1L1_HUMAN [Term] id: CCO:B0014130 name: SN1L1_HUMAN-Phosphothreonine460 def: "Protein SN1L1_HUMAN with the residue 460 substituted with Phosphothreonine" [UniProtKB:P57059] xref: UniProtKB:P57059 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001680 ! SN1L1_HUMAN [Term] id: CCO:B0014131 name: SN1L1_HUMAN-Phosphothreonine479 def: "Protein SN1L1_HUMAN with the residue 479 substituted with Phosphothreonine" [UniProtKB:P57059] xref: UniProtKB:P57059 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001680 ! SN1L1_HUMAN [Term] id: CCO:B0014132 name: SN1L1_HUMAN-Phosphoserine578 def: "Protein SN1L1_HUMAN with the residue 578 substituted with Phosphoserine" [UniProtKB:P57059] comment: By similarity xref: UniProtKB:P57059 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001680 ! SN1L1_HUMAN [Term] id: CCO:B0014136 name: SNF5_HUMAN-Phosphoserine129 def: "Protein SNF5_HUMAN with the residue 129 substituted with Phosphoserine" [UniProtKB:Q12824] xref: UniProtKB:Q12824 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001732 ! SNF5_HUMAN [Term] id: CCO:B0014137 name: SNIP1_HUMAN-Phosphoserine35 def: "Protein SNIP1_HUMAN with the residue 35 substituted with Phosphoserine" [UniProtKB:Q8TAD8] xref: UniProtKB:Q8TAD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:B0014138 name: SNIP1_HUMAN-Phosphoserine89 def: "Protein SNIP1_HUMAN with the residue 89 substituted with Phosphoserine" [UniProtKB:Q8TAD8] xref: UniProtKB:Q8TAD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:B0014139 name: SNIP1_HUMAN-Phosphoserine91 def: "Protein SNIP1_HUMAN with the residue 91 substituted with Phosphoserine" [UniProtKB:Q8TAD8] xref: UniProtKB:Q8TAD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:B0014140 name: SNIP1_HUMAN-Phosphoserine153 def: "Protein SNIP1_HUMAN with the residue 153 substituted with Phosphoserine" [UniProtKB:Q8TAD8] xref: UniProtKB:Q8TAD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:B0014141 name: SNIP1_HUMAN-Phosphothreonine169 def: "Protein SNIP1_HUMAN with the residue 169 substituted with Phosphothreonine" [UniProtKB:Q8TAD8] xref: UniProtKB:Q8TAD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:B0014142 name: SNIP1_HUMAN-Phosphoserine202 def: "Protein SNIP1_HUMAN with the residue 202 substituted with Phosphoserine" [UniProtKB:Q8TAD8] xref: UniProtKB:Q8TAD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:B0014143 name: SNIP1_HUMAN-Phosphoserine394 def: "Protein SNIP1_HUMAN with the residue 394 substituted with Phosphoserine" [UniProtKB:Q8TAD8] comment: By similarity xref: UniProtKB:Q8TAD8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:B0014144 name: SNUT1_HUMAN-Phosphothreonine392 def: "Protein SNUT1_HUMAN with the residue 392 substituted with Phosphothreonine" [UniProtKB:O43290] xref: UniProtKB:O43290 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001388 ! SNUT1_HUMAN [Term] id: CCO:B0014145 name: SNUT1_HUMAN-Phosphothreonine430 def: "Protein SNUT1_HUMAN with the residue 430 substituted with Phosphothreonine" [UniProtKB:O43290] xref: UniProtKB:O43290 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001388 ! SNUT1_HUMAN [Term] id: CCO:B0014146 name: SNUT1_HUMAN-Phosphoserine448 def: "Protein SNUT1_HUMAN with the residue 448 substituted with Phosphoserine" [UniProtKB:O43290] xref: UniProtKB:O43290 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001388 ! SNUT1_HUMAN [Term] id: CCO:B0014147 name: SNUT1_HUMAN-Phosphoserine591 def: "Protein SNUT1_HUMAN with the residue 591 substituted with Phosphoserine" [UniProtKB:O43290] xref: UniProtKB:O43290 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001388 ! SNUT1_HUMAN [Term] id: CCO:B0014148 name: SNUT1_HUMAN-Phosphoserine596 def: "Protein SNUT1_HUMAN with the residue 596 substituted with Phosphoserine" [UniProtKB:O43290] xref: UniProtKB:O43290 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001388 ! SNUT1_HUMAN [Term] id: CCO:B0014149 name: SNUT1_HUMAN-Phosphoserine598 def: "Protein SNUT1_HUMAN with the residue 598 substituted with Phosphoserine" [UniProtKB:O43290] xref: UniProtKB:O43290 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001388 ! SNUT1_HUMAN [Term] id: CCO:B0014150 name: SNUT1_HUMAN-Phosphothreonine695 def: "Protein SNUT1_HUMAN with the residue 695 substituted with Phosphothreonine" [UniProtKB:O43290] xref: UniProtKB:O43290 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001388 ! SNUT1_HUMAN [Term] id: CCO:B0014151 name: SNX9_HUMAN-Phosphoserine176 def: "Protein SNX9_HUMAN with the residue 176 substituted with Phosphoserine" [UniProtKB:Q9Y5X1] comment: By similarity xref: UniProtKB:Q9Y5X1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005559 ! SNX9_HUMAN [Term] id: CCO:B0014152 name: SOS1_HUMAN-Phosphoserine1043 def: "Protein SOS1_HUMAN with the residue 1043 substituted with Phosphoserine" [UniProtKB:Q07889] xref: UniProtKB:Q07889 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005383 ! SOS1_HUMAN [Term] id: CCO:B0014153 name: SOS1_HUMAN-Phosphoserine1078 def: "Protein SOS1_HUMAN with the residue 1078 substituted with Phosphoserine" [UniProtKB:Q07889] comment: By similarity xref: UniProtKB:Q07889 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005383 ! SOS1_HUMAN [Term] id: CCO:B0014154 name: SOS1_HUMAN-Phosphoserine1082 def: "Protein SOS1_HUMAN with the residue 1082 substituted with Phosphoserine" [UniProtKB:Q07889] xref: UniProtKB:Q07889 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005383 ! SOS1_HUMAN [Term] id: CCO:B0014155 name: SOS1_HUMAN-Phosphoserine1210 def: "Protein SOS1_HUMAN with the residue 1210 substituted with Phosphoserine" [UniProtKB:Q07889] xref: UniProtKB:Q07889 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005383 ! SOS1_HUMAN [Term] id: CCO:B0014156 name: SP1_HUMAN-Phosphoserine7 def: "Protein SP1_HUMAN with the residue 7 substituted with Phosphoserine" [UniProtKB:P08047] comment: By similarity xref: UniProtKB:P08047 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005485 ! SP1_HUMAN [Term] id: CCO:B0014157 name: SP1_HUMAN-Phosphoserine59 def: "Protein SP1_HUMAN with the residue 59 substituted with Phosphoserine" [UniProtKB:P08047] xref: UniProtKB:P08047 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005485 ! SP1_HUMAN [Term] id: CCO:B0014158 name: SPAG5_HUMAN-Phosphoserine12 def: "Protein SPAG5_HUMAN with the residue 12 substituted with Phosphoserine" [UniProtKB:Q96R06] comment: By similarity xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014159 name: SPAG5_HUMAN-Phosphoserine14 def: "Protein SPAG5_HUMAN with the residue 14 substituted with Phosphoserine" [UniProtKB:Q96R06] comment: By similarity xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014160 name: SPAG5_HUMAN-Phosphoserine62 def: "Protein SPAG5_HUMAN with the residue 62 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014161 name: SPAG5_HUMAN-Phosphoserine66 def: "Protein SPAG5_HUMAN with the residue 66 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014162 name: SPAG5_HUMAN-Phosphothreonine111 def: "Protein SPAG5_HUMAN with the residue 111 substituted with Phosphothreonine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014163 name: SPAG5_HUMAN-Phosphoserine135 def: "Protein SPAG5_HUMAN with the residue 135 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014164 name: SPAG5_HUMAN-Phosphoserine249 def: "Protein SPAG5_HUMAN with the residue 249 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000434 ! microtubule relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014165 name: SPAG5_HUMAN-Phosphoserine334 def: "Protein SPAG5_HUMAN with the residue 334 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014166 name: SPAG5_HUMAN-Phosphoserine341 def: "Protein SPAG5_HUMAN with the residue 341 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014167 name: SPAG5_HUMAN-Phosphoserine353 def: "Protein SPAG5_HUMAN with the residue 353 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014168 name: SPAG5_HUMAN-Phosphoserine362 def: "Protein SPAG5_HUMAN with the residue 362 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014169 name: SPAG5_HUMAN-Phosphoserine364 def: "Protein SPAG5_HUMAN with the residue 364 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014170 name: SPAG5_HUMAN-Phosphothreonine377 def: "Protein SPAG5_HUMAN with the residue 377 substituted with Phosphothreonine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014171 name: SPAG5_HUMAN-Phosphothreonine389 def: "Protein SPAG5_HUMAN with the residue 389 substituted with Phosphothreonine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014172 name: SPAG5_HUMAN-Phosphoserine401 def: "Protein SPAG5_HUMAN with the residue 401 substituted with Phosphoserine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014173 name: SPAG5_HUMAN-Phosphothreonine937 def: "Protein SPAG5_HUMAN with the residue 937 substituted with Phosphothreonine" [UniProtKB:Q96R06] xref: UniProtKB:Q96R06 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002058 ! SPAG5_HUMAN [Term] id: CCO:B0014174 name: SPC24_HUMAN-Phosphothreonine130 def: "Protein SPC24_HUMAN with the residue 130 substituted with Phosphothreonine" [UniProtKB:Q8NBT2] xref: UniProtKB:Q8NBT2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001973 ! SPC24_HUMAN [Term] id: CCO:B0014175 name: SPG7_HUMAN-Nitrated tyrosine505 def: "Protein SPG7_HUMAN with the residue 505 substituted with Nitrated tyrosine" [UniProtKB:Q9UQ90] comment: By similarity xref: UniProtKB:Q9UQ90 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006236 ! SPG7_HUMAN [Term] id: CCO:B0014176 name: SPIN1_HUMAN-Phosphoserine38 def: "Protein SPIN1_HUMAN with the residue 38 substituted with Phosphoserine" [UniProtKB:Q9Y657] xref: UniProtKB:Q9Y657 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002262 ! SPIN1_HUMAN [Term] id: CCO:B0014177 name: SPIN1_HUMAN-Phosphoserine39 def: "Protein SPIN1_HUMAN with the residue 39 substituted with Phosphoserine" [UniProtKB:Q9Y657] xref: UniProtKB:Q9Y657 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002262 ! SPIN1_HUMAN [Term] id: CCO:B0014178 name: SPT5H_HUMAN-Phosphoserine666 def: "Protein SPT5H_HUMAN with the residue 666 substituted with Phosphoserine" [UniProtKB:O00267] xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014179 name: SPT5H_HUMAN-dimethylarginine681 def: "Protein SPT5H_HUMAN with the residue 681 substituted with dimethylarginine" [UniProtKB:O00267] comment: by PRMT1; alternate; xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014180 name: SPT5H_HUMAN-Omega-N-methylarginine681 def: "Protein SPT5H_HUMAN with the residue 681 substituted with Omega-N-methylarginine" [UniProtKB:O00267] comment: by PRMT1; alternate; xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014181 name: SPT5H_HUMAN-dimethylarginine696 def: "Protein SPT5H_HUMAN with the residue 696 substituted with dimethylarginine" [UniProtKB:O00267] comment: by PRMT1; alternate; xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014182 name: SPT5H_HUMAN-Omega-N-methylarginine696 def: "Protein SPT5H_HUMAN with the residue 696 substituted with Omega-N-methylarginine" [UniProtKB:O00267] comment: by PRMT1; alternate; xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014183 name: SPT5H_HUMAN-dimethylarginine698 def: "Protein SPT5H_HUMAN with the residue 698 substituted with dimethylarginine" [UniProtKB:O00267] comment: by PRMT5; alternate; xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014184 name: SPT5H_HUMAN-Omega-N-methylarginine698 def: "Protein SPT5H_HUMAN with the residue 698 substituted with Omega-N-methylarginine" [UniProtKB:O00267] comment: by PRMT1 and PRMT5; alternate; xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014185 name: SPT5H_HUMAN-Phosphothreonine709 def: "Protein SPT5H_HUMAN with the residue 709 substituted with Phosphothreonine" [UniProtKB:O00267] xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014186 name: SPT5H_HUMAN-Phosphotyrosine717 def: "Protein SPT5H_HUMAN with the residue 717 substituted with Phosphotyrosine" [UniProtKB:O00267] xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014187 name: SPT5H_HUMAN-Phosphothreonine775 def: "Protein SPT5H_HUMAN with the residue 775 substituted with Phosphothreonine" [UniProtKB:O00267] comment: by CDK9; xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014188 name: SPT5H_HUMAN-Phosphothreonine784 def: "Protein SPT5H_HUMAN with the residue 784 substituted with Phosphothreonine" [UniProtKB:O00267] comment: by CDK9; xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014189 name: SPT5H_HUMAN-Phosphothreonine1034 def: "Protein SPT5H_HUMAN with the residue 1034 substituted with Phosphothreonine" [UniProtKB:O00267] xref: UniProtKB:O00267 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001345 ! SPT5H_HUMAN [Term] id: CCO:B0014190 name: SPTB2_HUMAN-Phosphothreonine999 def: "Protein SPTB2_HUMAN with the residue 999 substituted with Phosphothreonine" [UniProtKB:Q01082] comment: By similarity xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0014191 name: SPTB2_HUMAN-Phosphoserine1918 def: "Protein SPTB2_HUMAN with the residue 1918 substituted with Phosphoserine" [UniProtKB:Q01082] comment: By similarity xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0014192 name: SPTB2_HUMAN-Phosphoserine2102 def: "Protein SPTB2_HUMAN with the residue 2102 substituted with Phosphoserine" [UniProtKB:Q01082] xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0014193 name: SPTB2_HUMAN-Phosphoserine2115 def: "Protein SPTB2_HUMAN with the residue 2115 substituted with Phosphoserine" [UniProtKB:Q01082] comment: By similarity xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0014194 name: SPTB2_HUMAN-Phosphoserine2128 def: "Protein SPTB2_HUMAN with the residue 2128 substituted with Phosphoserine" [UniProtKB:Q01082] xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0014195 name: SPTB2_HUMAN-Phosphoserine2138 def: "Protein SPTB2_HUMAN with the residue 2138 substituted with Phosphoserine" [UniProtKB:Q01082] xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0014196 name: SPTB2_HUMAN-Phosphoserine2165 def: "Protein SPTB2_HUMAN with the residue 2165 substituted with Phosphoserine" [UniProtKB:Q01082] xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0014197 name: SPTB2_HUMAN-Phosphoserine2169 def: "Protein SPTB2_HUMAN with the residue 2169 substituted with Phosphoserine" [UniProtKB:Q01082] xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0014198 name: SPTB2_HUMAN-Phosphothreonine2195 def: "Protein SPTB2_HUMAN with the residue 2195 substituted with Phosphothreonine" [UniProtKB:Q01082] comment: By similarity xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0014199 name: SPTC2_HUMAN-Phosphoserine384 def: "Protein SPTC2_HUMAN with the residue 384 substituted with Phosphoserine" [UniProtKB:O15270] xref: UniProtKB:O15270 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006017 ! SPTC2_HUMAN [Term] id: CCO:B0014200 name: SPTC2_HUMAN-Phosphotyrosine387 def: "Protein SPTC2_HUMAN with the residue 387 substituted with Phosphotyrosine" [UniProtKB:O15270] xref: UniProtKB:O15270 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006017 ! SPTC2_HUMAN [Term] id: CCO:B0014201 name: SRBS1_HUMAN-Phosphoserine89 def: "Protein SRBS1_HUMAN with the residue 89 substituted with Phosphoserine" [UniProtKB:Q9BX66] comment: By similarity xref: UniProtKB:Q9BX66 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005641 ! SRBS1_HUMAN [Term] id: CCO:B0014202 name: SRBS1_HUMAN-Phosphotyrosine134 def: "Protein SRBS1_HUMAN with the residue 134 substituted with Phosphotyrosine" [UniProtKB:Q9BX66] comment: By similarity xref: UniProtKB:Q9BX66 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005641 ! SRBS1_HUMAN [Term] id: CCO:B0014203 name: SRBS1_HUMAN-Phosphothreonine349 def: "Protein SRBS1_HUMAN with the residue 349 substituted with Phosphothreonine" [UniProtKB:Q9BX66] comment: By similarity xref: UniProtKB:Q9BX66 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005641 ! SRBS1_HUMAN [Term] id: CCO:B0014204 name: SRBS1_HUMAN-Phosphoserine481 def: "Protein SRBS1_HUMAN with the residue 481 substituted with Phosphoserine" [UniProtKB:Q9BX66] comment: By similarity xref: UniProtKB:Q9BX66 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005641 ! SRBS1_HUMAN [Term] id: CCO:B0014205 name: SRBS1_HUMAN-Phosphothreonine497 def: "Protein SRBS1_HUMAN with the residue 497 substituted with Phosphothreonine" [UniProtKB:Q9BX66] comment: By similarity xref: UniProtKB:Q9BX66 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005641 ! SRBS1_HUMAN [Term] id: CCO:B0014206 name: SRBS1_HUMAN-Phosphoserine556 def: "Protein SRBS1_HUMAN with the residue 556 substituted with Phosphoserine" [UniProtKB:Q9BX66] comment: By similarity xref: UniProtKB:Q9BX66 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005641 ! SRBS1_HUMAN [Term] id: CCO:B0014207 name: SRBS1_HUMAN-Phosphoserine640 def: "Protein SRBS1_HUMAN with the residue 640 substituted with Phosphoserine" [UniProtKB:Q9BX66] comment: By similarity xref: UniProtKB:Q9BX66 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005641 ! SRBS1_HUMAN [Term] id: CCO:B0014208 name: SRC_HUMAN-Phosphoserine17 def: "Protein SRC_HUMAN with the residue 17 substituted with Phosphoserine" [UniProtKB:P12931] xref: UniProtKB:P12931 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005464 ! SRC_HUMAN [Term] id: CCO:B0014209 name: SRC_HUMAN-Phosphoserine69 def: "Protein SRC_HUMAN with the residue 69 substituted with Phosphoserine" [UniProtKB:P12931] xref: UniProtKB:P12931 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005464 ! SRC_HUMAN [Term] id: CCO:B0014210 name: SRC_HUMAN-Phosphoserine75 def: "Protein SRC_HUMAN with the residue 75 substituted with Phosphoserine" [UniProtKB:P12931] xref: UniProtKB:P12931 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005464 ! SRC_HUMAN [Term] id: CCO:B0014211 name: SRC_HUMAN-Phosphotyrosine419 def: "Protein SRC_HUMAN with the residue 419 substituted with Phosphotyrosine" [UniProtKB:P12931] comment: by autocatalysis; xref: UniProtKB:P12931 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005464 ! SRC_HUMAN [Term] id: CCO:B0014212 name: SRC_HUMAN-Phosphotyrosine530 def: "Protein SRC_HUMAN with the residue 530 substituted with Phosphotyrosine" [UniProtKB:P12931] comment: by CSK; xref: UniProtKB:P12931 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005464 ! SRC_HUMAN [Term] id: CCO:B0014217 name: SSA27_HUMAN-Phosphoserine94 def: "Protein SSA27_HUMAN with the residue 94 substituted with Phosphoserine" [UniProtKB:O60232] xref: UniProtKB:O60232 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001405 ! SSA27_HUMAN [Term] id: CCO:B0014219 name: SSRP1_HUMAN-Phosphotyrosine311 def: "Protein SSRP1_HUMAN with the residue 311 substituted with Phosphotyrosine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014220 name: SSRP1_HUMAN-Phosphotyrosine441 def: "Protein SSRP1_HUMAN with the residue 441 substituted with Phosphotyrosine" [UniProtKB:Q08945] comment: By similarity xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014221 name: SSRP1_HUMAN-Phosphoserine444 def: "Protein SSRP1_HUMAN with the residue 444 substituted with Phosphoserine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014222 name: SSRP1_HUMAN-Phosphoserine510 def: "Protein SSRP1_HUMAN with the residue 510 substituted with Phosphoserine" [UniProtKB:Q08945] comment: by CK2; Probable xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014223 name: SSRP1_HUMAN-Phosphotyrosine554 def: "Protein SSRP1_HUMAN with the residue 554 substituted with Phosphotyrosine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014224 name: SSRP1_HUMAN-Phosphoserine561 def: "Protein SSRP1_HUMAN with the residue 561 substituted with Phosphoserine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014225 name: SSRP1_HUMAN-Phosphoserine657 def: "Protein SSRP1_HUMAN with the residue 657 substituted with Phosphoserine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014226 name: SSRP1_HUMAN-Phosphoserine667 def: "Protein SSRP1_HUMAN with the residue 667 substituted with Phosphoserine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014227 name: SSRP1_HUMAN-Phosphoserine668 def: "Protein SSRP1_HUMAN with the residue 668 substituted with Phosphoserine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014228 name: SSRP1_HUMAN-Phosphoserine671 def: "Protein SSRP1_HUMAN with the residue 671 substituted with Phosphoserine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014229 name: SSRP1_HUMAN-Phosphoserine672 def: "Protein SSRP1_HUMAN with the residue 672 substituted with Phosphoserine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014230 name: SSRP1_HUMAN-Phosphoserine673 def: "Protein SSRP1_HUMAN with the residue 673 substituted with Phosphoserine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014231 name: SSRP1_HUMAN-Phosphoserine688 def: "Protein SSRP1_HUMAN with the residue 688 substituted with Phosphoserine" [UniProtKB:Q08945] comment: by CK2; Probable xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0014232 name: ST5_HUMAN-Phosphoserine1011 def: "Protein ST5_HUMAN with the residue 1011 substituted with Phosphoserine" [UniProtKB:P78524] xref: UniProtKB:P78524 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006063 ! ST5_HUMAN [Term] id: CCO:B0014233 name: ST5_HUMAN-Phosphoserine1013 def: "Protein ST5_HUMAN with the residue 1013 substituted with Phosphoserine" [UniProtKB:P78524] xref: UniProtKB:P78524 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006063 ! ST5_HUMAN [Term] id: CCO:B0014234 name: ST5_HUMAN-Phosphoserine1015 def: "Protein ST5_HUMAN with the residue 1015 substituted with Phosphoserine" [UniProtKB:P78524] xref: UniProtKB:P78524 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006063 ! ST5_HUMAN [Term] id: CCO:B0014239 name: STAG1_HUMAN-Phosphoserine1069 def: "Protein STAG1_HUMAN with the residue 1069 substituted with Phosphoserine" [UniProtKB:Q8WVM7] comment: By similarity xref: UniProtKB:Q8WVM7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002004 ! STAG1_HUMAN [Term] id: CCO:B0014240 name: STAG1_HUMAN-Phosphoserine1070 def: "Protein STAG1_HUMAN with the residue 1070 substituted with Phosphoserine" [UniProtKB:Q8WVM7] comment: By similarity xref: UniProtKB:Q8WVM7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002004 ! STAG1_HUMAN [Term] id: CCO:B0014241 name: STAG2_HUMAN-Phosphoserine1061 def: "Protein STAG2_HUMAN with the residue 1061 substituted with Phosphoserine" [UniProtKB:Q8N3U4] xref: UniProtKB:Q8N3U4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001962 ! STAG2_HUMAN [Term] id: CCO:B0014242 name: STAG2_HUMAN-Phosphothreonine1160 def: "Protein STAG2_HUMAN with the residue 1160 substituted with Phosphothreonine" [UniProtKB:Q8N3U4] comment: By similarity xref: UniProtKB:Q8N3U4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001962 ! STAG2_HUMAN [Term] id: CCO:B0014245 name: STAT3_HUMAN-Phosphoserine691 def: "Protein STAT3_HUMAN with the residue 691 substituted with Phosphoserine" [UniProtKB:P40763] xref: UniProtKB:P40763 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005379 ! STAT3_HUMAN [Term] id: CCO:B0014246 name: STAT3_HUMAN-Phosphotyrosine705 def: "Protein STAT3_HUMAN with the residue 705 substituted with Phosphotyrosine" [UniProtKB:P40763] xref: UniProtKB:P40763 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005379 ! STAT3_HUMAN [Term] id: CCO:B0014247 name: STAT3_HUMAN-Phosphoserine727 def: "Protein STAT3_HUMAN with the residue 727 substituted with Phosphoserine" [UniProtKB:P40763] comment: By similarity xref: UniProtKB:P40763 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005379 ! STAT3_HUMAN [Term] id: CCO:B0014249 name: STEA3_HUMAN-Phosphoserine20 def: "Protein STEA3_HUMAN with the residue 20 substituted with Phosphoserine" [UniProtKB:Q658P3] comment: By similarity xref: UniProtKB:Q658P3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001903 ! STEA3_HUMAN [Term] id: CCO:B0014250 name: STK11_HUMAN-Phosphoserine31 def: "Protein STK11_HUMAN with the residue 31 substituted with Phosphoserine" [UniProtKB:Q15831] comment: By similarity xref: UniProtKB:Q15831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001814 ! STK11_HUMAN [Term] id: CCO:B0014251 name: STK11_HUMAN-Phosphothreonine336 def: "Protein STK11_HUMAN with the residue 336 substituted with Phosphothreonine" [UniProtKB:Q15831] comment: by autocatalysis; xref: UniProtKB:Q15831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001814 ! STK11_HUMAN [Term] id: CCO:B0014252 name: STK11_HUMAN-Phosphothreonine363 def: "Protein STK11_HUMAN with the residue 363 substituted with Phosphothreonine" [UniProtKB:Q15831] comment: by autocatalysis; xref: UniProtKB:Q15831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001814 ! STK11_HUMAN [Term] id: CCO:B0014253 name: STK11_HUMAN-Phosphoserine428 def: "Protein STK11_HUMAN with the residue 428 substituted with Phosphoserine" [UniProtKB:Q15831] comment: by PKA; Potential xref: UniProtKB:Q15831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001814 ! STK11_HUMAN [Term] id: CCO:B0014254 name: STK4_HUMAN-Phosphothreonine183 def: "Protein STK4_HUMAN with the residue 183 substituted with Phosphothreonine" [UniProtKB:Q13043] comment: by autocatalysis; xref: UniProtKB:Q13043 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005702 ! STK4_HUMAN [Term] id: CCO:B0014255 name: STK4_HUMAN-Phosphoserine320 def: "Protein STK4_HUMAN with the residue 320 substituted with Phosphoserine" [UniProtKB:Q13043] comment: By similarity xref: UniProtKB:Q13043 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005702 ! STK4_HUMAN [Term] id: CCO:B0014256 name: STK4_HUMAN-Phosphotyrosine433 def: "Protein STK4_HUMAN with the residue 433 substituted with Phosphotyrosine" [UniProtKB:Q13043] xref: UniProtKB:Q13043 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005702 ! STK4_HUMAN [Term] id: CCO:B0014257 name: STK6_HUMAN-Phosphoserine369 def: "Protein STK6_HUMAN with the residue 369 substituted with Phosphoserine" [UniProtKB:O14965] xref: UniProtKB:O14965 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001363 ! STK6_HUMAN [Term] id: CCO:B0014258 name: STMN1_HUMAN-N-acetylalanine2 def: "Protein STMN1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P16949] xref: UniProtKB:P16949 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001528 ! STMN1_HUMAN [Term] id: CCO:B0014259 name: STMN1_HUMAN-Phosphoserine16 def: "Protein STMN1_HUMAN with the residue 16 substituted with Phosphoserine" [UniProtKB:P16949] xref: UniProtKB:P16949 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001528 ! STMN1_HUMAN [Term] id: CCO:B0014260 name: STMN1_HUMAN-Phosphoserine25 def: "Protein STMN1_HUMAN with the residue 25 substituted with Phosphoserine" [UniProtKB:P16949] comment: by CDC2 and MAPK; xref: UniProtKB:P16949 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001528 ! STMN1_HUMAN [Term] id: CCO:B0014261 name: STMN1_HUMAN-Phosphoserine28 def: "Protein STMN1_HUMAN with the residue 28 substituted with Phosphoserine" [UniProtKB:P16949] xref: UniProtKB:P16949 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001528 ! STMN1_HUMAN [Term] id: CCO:B0014262 name: STMN1_HUMAN-Phosphoserine38 def: "Protein STMN1_HUMAN with the residue 38 substituted with Phosphoserine" [UniProtKB:P16949] comment: by CDC2; xref: UniProtKB:P16949 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001528 ! STMN1_HUMAN [Term] id: CCO:B0014263 name: STMN1_HUMAN-Phosphoserine46 def: "Protein STMN1_HUMAN with the residue 46 substituted with Phosphoserine" [UniProtKB:P16949] comment: By similarity xref: UniProtKB:P16949 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001528 ! STMN1_HUMAN [Term] id: CCO:B0014264 name: STMN1_HUMAN-Phosphoserine63 def: "Protein STMN1_HUMAN with the residue 63 substituted with Phosphoserine" [UniProtKB:P16949] comment: by PKA; xref: UniProtKB:P16949 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001528 ! STMN1_HUMAN [Term] id: CCO:B0014265 name: STMN1_HUMAN-Phosphothreonine146 def: "Protein STMN1_HUMAN with the residue 146 substituted with Phosphothreonine" [UniProtKB:P16949] xref: UniProtKB:P16949 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001528 ! STMN1_HUMAN [Term] id: CCO:B0014266 name: STRAD_HUMAN-Phosphothreonine329 def: "Protein STRAD_HUMAN with the residue 329 substituted with Phosphothreonine" [UniProtKB:Q7RTN6] comment: by STK11; xref: UniProtKB:Q7RTN6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001932 ! STRAD_HUMAN [Term] id: CCO:B0014267 name: STRAD_HUMAN-Phosphothreonine419 def: "Protein STRAD_HUMAN with the residue 419 substituted with Phosphothreonine" [UniProtKB:Q7RTN6] comment: by STK11; xref: UniProtKB:Q7RTN6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001932 ! STRAD_HUMAN [Term] id: CCO:B0014268 name: STRN3_HUMAN-Phosphoserine229 def: "Protein STRN3_HUMAN with the residue 229 substituted with Phosphoserine" [UniProtKB:Q13033] xref: UniProtKB:Q13033 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001737 ! STRN3_HUMAN [Term] id: CCO:B0014269 name: STRN4_HUMAN-Phosphoserine206 def: "Protein STRN4_HUMAN with the residue 206 substituted with Phosphoserine" [UniProtKB:Q9NRL3] comment: By similarity xref: UniProtKB:Q9NRL3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006352 ! STRN4_HUMAN [Term] id: CCO:B0014270 name: SUGT1_HUMAN-Phosphothreonine265 def: "Protein SUGT1_HUMAN with the residue 265 substituted with Phosphothreonine" [UniProtKB:Q9Y2Z0] xref: UniProtKB:Q9Y2Z0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002252 ! SUGT1_HUMAN [Term] id: CCO:B0014271 name: SUGT1_HUMAN-Phosphotyrosine317 def: "Protein SUGT1_HUMAN with the residue 317 substituted with Phosphotyrosine" [UniProtKB:Q9Y2Z0] xref: UniProtKB:Q9Y2Z0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002252 ! SUGT1_HUMAN [Term] id: CCO:B0014272 name: SUMO1_HUMAN-Phosphoserine2 def: "Protein SUMO1_HUMAN with the residue 2 substituted with Phosphoserine" [UniProtKB:P63165] xref: UniProtKB:P63165 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005472 ! SUMO1_HUMAN [Term] id: CCO:B0014273 name: SUV91_HUMAN-Phosphoserine391 def: "Protein SUV91_HUMAN with the residue 391 substituted with Phosphoserine" [UniProtKB:O43463] xref: UniProtKB:O43463 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001391 ! SUV91_HUMAN [Term] id: CCO:B0014274 name: SYK_HUMAN-Phosphoserine596 def: "Protein SYK_HUMAN with the residue 596 substituted with Phosphoserine" [UniProtKB:Q15046] comment: By similarity xref: UniProtKB:Q15046 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006279 ! SYK_HUMAN [Term] id: CCO:B0014275 name: T2FA_HUMAN-Phosphoserine217 def: "Protein T2FA_HUMAN with the residue 217 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014276 name: T2FA_HUMAN-Phosphoserine218 def: "Protein T2FA_HUMAN with the residue 218 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014277 name: T2FA_HUMAN-Phosphoserine221 def: "Protein T2FA_HUMAN with the residue 221 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014278 name: T2FA_HUMAN-Phosphoserine224 def: "Protein T2FA_HUMAN with the residue 224 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014279 name: T2FA_HUMAN-Phosphoserine305 def: "Protein T2FA_HUMAN with the residue 305 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014280 name: T2FA_HUMAN-Phosphoserine307 def: "Protein T2FA_HUMAN with the residue 307 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014281 name: T2FA_HUMAN-Phosphoserine308 def: "Protein T2FA_HUMAN with the residue 308 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014282 name: T2FA_HUMAN-Phosphoserine311 def: "Protein T2FA_HUMAN with the residue 311 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014283 name: T2FA_HUMAN-Phosphoserine342 def: "Protein T2FA_HUMAN with the residue 342 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014284 name: T2FA_HUMAN-Phosphoserine345 def: "Protein T2FA_HUMAN with the residue 345 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014285 name: T2FA_HUMAN-Phosphoserine347 def: "Protein T2FA_HUMAN with the residue 347 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014286 name: T2FA_HUMAN-Phosphoserine348 def: "Protein T2FA_HUMAN with the residue 348 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014287 name: T2FA_HUMAN-Phosphoserine351 def: "Protein T2FA_HUMAN with the residue 351 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014288 name: T2FA_HUMAN-Phosphoserine355 def: "Protein T2FA_HUMAN with the residue 355 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014289 name: T2FA_HUMAN-Phosphoserine385 def: "Protein T2FA_HUMAN with the residue 385 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014290 name: T2FA_HUMAN-Phosphothreonine389 def: "Protein T2FA_HUMAN with the residue 389 substituted with Phosphothreonine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014291 name: T2FA_HUMAN-Phosphoserine433 def: "Protein T2FA_HUMAN with the residue 433 substituted with Phosphoserine" [UniProtKB:P35269] xref: UniProtKB:P35269 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:B0014292 name: TAB2_HUMAN-Phosphoserine450 def: "Protein TAB2_HUMAN with the residue 450 substituted with Phosphoserine" [UniProtKB:Q9NYJ8] comment: By similarity xref: UniProtKB:Q9NYJ8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005532 ! TAB2_HUMAN [Term] id: CCO:B0014293 name: TACC1_HUMAN-Phosphoserine44 def: "Protein TACC1_HUMAN with the residue 44 substituted with Phosphoserine" [UniProtKB:O75410] xref: UniProtKB:O75410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001425 ! TACC1_HUMAN [Term] id: CCO:B0014294 name: TACC1_HUMAN-Phosphoserine50 def: "Protein TACC1_HUMAN with the residue 50 substituted with Phosphoserine" [UniProtKB:O75410] xref: UniProtKB:O75410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001425 ! TACC1_HUMAN [Term] id: CCO:B0014295 name: TACC1_HUMAN-Phosphoserine52 def: "Protein TACC1_HUMAN with the residue 52 substituted with Phosphoserine" [UniProtKB:O75410] xref: UniProtKB:O75410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001425 ! TACC1_HUMAN [Term] id: CCO:B0014296 name: TACC1_HUMAN-Phosphoserine54 def: "Protein TACC1_HUMAN with the residue 54 substituted with Phosphoserine" [UniProtKB:O75410] xref: UniProtKB:O75410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001425 ! TACC1_HUMAN [Term] id: CCO:B0014297 name: TACC1_HUMAN-Phosphoserine55 def: "Protein TACC1_HUMAN with the residue 55 substituted with Phosphoserine" [UniProtKB:O75410] xref: UniProtKB:O75410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001425 ! TACC1_HUMAN [Term] id: CCO:B0014298 name: TACC1_HUMAN-Phosphoserine57 def: "Protein TACC1_HUMAN with the residue 57 substituted with Phosphoserine" [UniProtKB:O75410] xref: UniProtKB:O75410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001425 ! TACC1_HUMAN [Term] id: CCO:B0014299 name: TACC1_HUMAN-Phosphotyrosine533 def: "Protein TACC1_HUMAN with the residue 533 substituted with Phosphotyrosine" [UniProtKB:O75410] xref: UniProtKB:O75410 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001425 ! TACC1_HUMAN [Term] id: CCO:B0014300 name: TACC2_HUMAN-Phosphoserine1946 def: "Protein TACC2_HUMAN with the residue 1946 substituted with Phosphoserine" [UniProtKB:O95359] comment: By similarity xref: UniProtKB:O95359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006276 ! TACC2_HUMAN [Term] id: CCO:B0014301 name: TACC2_HUMAN-Phosphoserine1949 def: "Protein TACC2_HUMAN with the residue 1949 substituted with Phosphoserine" [UniProtKB:O95359] comment: By similarity xref: UniProtKB:O95359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006276 ! TACC2_HUMAN [Term] id: CCO:B0014302 name: TACC2_HUMAN-Phosphoserine2256 def: "Protein TACC2_HUMAN with the residue 2256 substituted with Phosphoserine" [UniProtKB:O95359] xref: UniProtKB:O95359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006276 ! TACC2_HUMAN [Term] id: CCO:B0014303 name: TACC2_HUMAN-Phosphoserine2317 def: "Protein TACC2_HUMAN with the residue 2317 substituted with Phosphoserine" [UniProtKB:O95359] comment: By similarity xref: UniProtKB:O95359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006276 ! TACC2_HUMAN [Term] id: CCO:B0014304 name: TACC2_HUMAN-Phosphoserine2512 def: "Protein TACC2_HUMAN with the residue 2512 substituted with Phosphoserine" [UniProtKB:O95359] xref: UniProtKB:O95359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006276 ! TACC2_HUMAN [Term] id: CCO:B0014305 name: TAF1_HUMAN-Phosphoserine137 def: "Protein TAF1_HUMAN with the residue 137 substituted with Phosphoserine" [UniProtKB:P21675] comment: by autocatalysis; xref: UniProtKB:P21675 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001543 ! TAF1_HUMAN [Term] id: CCO:B0014306 name: TAF1_HUMAN-Phosphoserine307 def: "Protein TAF1_HUMAN with the residue 307 substituted with Phosphoserine" [UniProtKB:P21675] comment: by autocatalysis; xref: UniProtKB:P21675 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001543 ! TAF1_HUMAN [Term] id: CCO:B0014307 name: TAF9_HUMAN-Phosphoserine85 def: "Protein TAF9_HUMAN with the residue 85 substituted with Phosphoserine" [UniProtKB:Q16594] xref: UniProtKB:Q16594 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005938 ! TAF9_HUMAN [Term] id: CCO:B0014308 name: TBA1A_HUMAN-Phosphoserine6 def: "Protein TBA1A_HUMAN with the residue 6 substituted with Phosphoserine" [UniProtKB:Q71U36] comment: By similarity xref: UniProtKB:Q71U36 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005772 ! TBA1A_HUMAN [Term] id: CCO:B0014309 name: TBA1A_HUMAN-Phosphotyrosine272 def: "Protein TBA1A_HUMAN with the residue 272 substituted with Phosphotyrosine" [UniProtKB:Q71U36] comment: By similarity xref: UniProtKB:Q71U36 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005772 ! TBA1A_HUMAN [Term] id: CCO:B0014310 name: TBA1A_HUMAN-Phosphoserine439 def: "Protein TBA1A_HUMAN with the residue 439 substituted with Phosphoserine" [UniProtKB:Q71U36] xref: UniProtKB:Q71U36 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005772 ! TBA1A_HUMAN [Term] id: CCO:B0014312 name: TBA4A_HUMAN-Phosphoserine6 def: "Protein TBA4A_HUMAN with the residue 6 substituted with Phosphoserine" [UniProtKB:P68366] comment: By similarity xref: UniProtKB:P68366 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005449 ! TBA4A_HUMAN [Term] id: CCO:B0014313 name: TBA4A_HUMAN-Phosphotyrosine161 def: "Protein TBA4A_HUMAN with the residue 161 substituted with Phosphotyrosine" [UniProtKB:P68366] xref: UniProtKB:P68366 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005449 ! TBA4A_HUMAN [Term] id: CCO:B0014314 name: TBA4A_HUMAN-Phosphotyrosine272 def: "Protein TBA4A_HUMAN with the residue 272 substituted with Phosphotyrosine" [UniProtKB:P68366] xref: UniProtKB:P68366 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005449 ! TBA4A_HUMAN [Term] id: CCO:B0014315 name: TBB4_HUMAN-Phosphothreonine290 def: "Protein TBB4_HUMAN with the residue 290 substituted with Phosphothreonine" [UniProtKB:P04350] xref: UniProtKB:P04350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006167 ! TBB4_HUMAN [Term] id: CCO:B0014316 name: TBB4_HUMAN-Phosphothreonine366 def: "Protein TBB4_HUMAN with the residue 366 substituted with Phosphothreonine" [UniProtKB:P04350] comment: By similarity xref: UniProtKB:P04350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006167 ! TBB4_HUMAN [Term] id: CCO:B0014317 name: TBB5_HUMAN-Phosphotyrosine36 def: "Protein TBB5_HUMAN with the residue 36 substituted with Phosphotyrosine" [UniProtKB:P07437] xref: UniProtKB:P07437 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005727 ! TBB5_HUMAN [Term] id: CCO:B0014318 name: TBK1_HUMAN-Phosphoserine172 def: "Protein TBK1_HUMAN with the residue 172 substituted with Phosphoserine" [UniProtKB:Q9UHD2] comment: by autocatalysis; xref: UniProtKB:Q9UHD2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005533 ! TBK1_HUMAN [Term] id: CCO:B0014319 name: TBL1R_HUMAN-Phosphoserine119 def: "Protein TBL1R_HUMAN with the residue 119 substituted with Phosphoserine" [UniProtKB:Q9BZK7] xref: UniProtKB:Q9BZK7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006041 ! TBL1R_HUMAN [Term] id: CCO:B0014320 name: TBRG4_HUMAN-Phosphothreonine65 def: "Protein TBRG4_HUMAN with the residue 65 substituted with Phosphothreonine" [UniProtKB:Q969Z0] xref: UniProtKB:Q969Z0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002030 ! TBRG4_HUMAN [Term] id: CCO:B0014321 name: TBX3_HUMAN-Phosphoserine375 def: "Protein TBX3_HUMAN with the residue 375 substituted with Phosphoserine" [UniProtKB:O15119] comment: By similarity xref: UniProtKB:O15119 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001365 ! TBX3_HUMAN [Term] id: CCO:B0014322 name: TBX3_HUMAN-Phosphoserine456 def: "Protein TBX3_HUMAN with the residue 456 substituted with Phosphoserine" [UniProtKB:O15119] xref: UniProtKB:O15119 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001365 ! TBX3_HUMAN [Term] id: CCO:B0014324 name: TCPG_HUMAN-Phosphothreonine254 def: "Protein TCPG_HUMAN with the residue 254 substituted with Phosphothreonine" [UniProtKB:P49368] xref: UniProtKB:P49368 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005253 ! TCPG_HUMAN [Term] id: CCO:B0014326 name: TCRG1_HUMAN-Phosphoserine481 def: "Protein TCRG1_HUMAN with the residue 481 substituted with Phosphoserine" [UniProtKB:O14776] xref: UniProtKB:O14776 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005396 ! TCRG1_HUMAN [Term] id: CCO:B0014327 name: TCRG1_HUMAN-Phosphothreonine489 def: "Protein TCRG1_HUMAN with the residue 489 substituted with Phosphothreonine" [UniProtKB:O14776] xref: UniProtKB:O14776 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005396 ! TCRG1_HUMAN [Term] id: CCO:B0014328 name: TE2IP_HUMAN-Phosphoserine154 def: "Protein TE2IP_HUMAN with the residue 154 substituted with Phosphoserine" [UniProtKB:Q9NYB0] xref: UniProtKB:Q9NYB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005505 ! TE2IP_HUMAN [Term] id: CCO:B0014329 name: TE2IP_HUMAN-Phosphoserine156 def: "Protein TE2IP_HUMAN with the residue 156 substituted with Phosphoserine" [UniProtKB:Q9NYB0] xref: UniProtKB:Q9NYB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005505 ! TE2IP_HUMAN [Term] id: CCO:B0014330 name: TE2IP_HUMAN-Phosphoserine203 def: "Protein TE2IP_HUMAN with the residue 203 substituted with Phosphoserine" [UniProtKB:Q9NYB0] xref: UniProtKB:Q9NYB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005505 ! TE2IP_HUMAN [Term] id: CCO:B0014331 name: TE2IP_HUMAN-Phosphoserine206 def: "Protein TE2IP_HUMAN with the residue 206 substituted with Phosphoserine" [UniProtKB:Q9NYB0] xref: UniProtKB:Q9NYB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005505 ! TE2IP_HUMAN [Term] id: CCO:B0014332 name: TERF1_HUMAN-Phosphoserine11 def: "Protein TERF1_HUMAN with the residue 11 substituted with Phosphoserine" [UniProtKB:P54274] xref: UniProtKB:P54274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001667 ! TERF1_HUMAN [Term] id: CCO:B0014333 name: TERF1_HUMAN-Phosphoserine219 def: "Protein TERF1_HUMAN with the residue 219 substituted with Phosphoserine" [UniProtKB:P54274] comment: by ATM; xref: UniProtKB:P54274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001667 ! TERF1_HUMAN [Term] id: CCO:B0014334 name: TERF2_HUMAN-Phosphoserine323 def: "Protein TERF2_HUMAN with the residue 323 substituted with Phosphoserine" [UniProtKB:Q15554] xref: UniProtKB:Q15554 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001810 ! TERF2_HUMAN [Term] id: CCO:B0014335 name: TERF2_HUMAN-Phosphoserine368 def: "Protein TERF2_HUMAN with the residue 368 substituted with Phosphoserine" [UniProtKB:Q15554] xref: UniProtKB:Q15554 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001810 ! TERF2_HUMAN [Term] id: CCO:B0014336 name: TERF2_HUMAN-Phosphoserine380 def: "Protein TERF2_HUMAN with the residue 380 substituted with Phosphoserine" [UniProtKB:Q15554] xref: UniProtKB:Q15554 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0005630 ! telomeric DNA binding relationship: has_function CCO:F0005790 ! single-stranded telomeric DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000108 ! chromosome, telomeric region relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000296 ! chromosome relationship: transformation_of CCO:B0001810 ! TERF2_HUMAN [Term] id: CCO:B0014337 name: TF3C1_HUMAN-Phosphoserine739 def: "Protein TF3C1_HUMAN with the residue 739 substituted with Phosphoserine" [UniProtKB:Q12789] xref: UniProtKB:Q12789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006211 ! TF3C1_HUMAN [Term] id: CCO:B0014338 name: TF3C1_HUMAN-Phosphoserine751 def: "Protein TF3C1_HUMAN with the residue 751 substituted with Phosphoserine" [UniProtKB:Q12789] xref: UniProtKB:Q12789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006211 ! TF3C1_HUMAN [Term] id: CCO:B0014339 name: TF3C1_HUMAN-Phosphoserine1062 def: "Protein TF3C1_HUMAN with the residue 1062 substituted with Phosphoserine" [UniProtKB:Q12789] xref: UniProtKB:Q12789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006211 ! TF3C1_HUMAN [Term] id: CCO:B0014340 name: TF3C1_HUMAN-Phosphoserine1068 def: "Protein TF3C1_HUMAN with the residue 1068 substituted with Phosphoserine" [UniProtKB:Q12789] xref: UniProtKB:Q12789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006211 ! TF3C1_HUMAN [Term] id: CCO:B0014341 name: TF3C1_HUMAN-Phosphoserine1653 def: "Protein TF3C1_HUMAN with the residue 1653 substituted with Phosphoserine" [UniProtKB:Q12789] xref: UniProtKB:Q12789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006211 ! TF3C1_HUMAN [Term] id: CCO:B0014342 name: TF3C1_HUMAN-Phosphoserine1865 def: "Protein TF3C1_HUMAN with the residue 1865 substituted with Phosphoserine" [UniProtKB:Q12789] xref: UniProtKB:Q12789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006211 ! TF3C1_HUMAN [Term] id: CCO:B0014343 name: TF3C1_HUMAN-Phosphoserine1868 def: "Protein TF3C1_HUMAN with the residue 1868 substituted with Phosphoserine" [UniProtKB:Q12789] xref: UniProtKB:Q12789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006211 ! TF3C1_HUMAN [Term] id: CCO:B0014344 name: TF3C1_HUMAN-Phosphoserine1969 def: "Protein TF3C1_HUMAN with the residue 1969 substituted with Phosphoserine" [UniProtKB:Q12789] xref: UniProtKB:Q12789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006211 ! TF3C1_HUMAN [Term] id: CCO:B0014345 name: TF65_HUMAN-Phosphoserine276 def: "Protein TF65_HUMAN with the residue 276 substituted with Phosphoserine" [UniProtKB:Q04206] comment: by RPS6KA4 and RPS6KA5; xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0014346 name: TFDP1_HUMAN-Phosphoserine23 def: "Protein TFDP1_HUMAN with the residue 23 substituted with Phosphoserine" [UniProtKB:Q14186] comment: by CDK2; Potential xref: UniProtKB:Q14186 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001776 ! TFDP1_HUMAN [Term] id: CCO:B0014347 name: TFDP2_HUMAN-Phosphoserine24 def: "Protein TFDP2_HUMAN with the residue 24 substituted with Phosphoserine" [UniProtKB:Q14188] comment: by CDK2; Potential xref: UniProtKB:Q14188 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0000299 ! transcription cofactor activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000272 ! transcription factor complex relationship: transformation_of CCO:B0001777 ! TFDP2_HUMAN [Term] id: CCO:B0014348 name: TFDP2_HUMAN-Phosphoserine42 def: "Protein TFDP2_HUMAN with the residue 42 substituted with Phosphoserine" [UniProtKB:Q14188] comment: by CDK2; Potential xref: UniProtKB:Q14188 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001777 ! TFDP2_HUMAN [Term] id: CCO:B0014350 name: THIO_HUMAN-N6-acetyllysine94 def: "Protein THIO_HUMAN with the residue 94 substituted with N6-acetyllysine" [UniProtKB:P10599] xref: UniProtKB:P10599 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005808 ! THIO_HUMAN [Term] id: CCO:B0014351 name: THIO_HUMAN-Phosphothreonine100 def: "Protein THIO_HUMAN with the residue 100 substituted with Phosphothreonine" [UniProtKB:P10599] xref: UniProtKB:P10599 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005808 ! THIO_HUMAN [Term] id: CCO:B0014362 name: TIF1B_HUMAN-N-acetylalanine2 def: "Protein TIF1B_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014363 name: TIF1B_HUMAN-Phosphoserine19 def: "Protein TIF1B_HUMAN with the residue 19 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014364 name: TIF1B_HUMAN-Phosphoserine50 def: "Protein TIF1B_HUMAN with the residue 50 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014365 name: TIF1B_HUMAN-Phosphoserine440 def: "Protein TIF1B_HUMAN with the residue 440 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014366 name: TIF1B_HUMAN-Phosphoserine466 def: "Protein TIF1B_HUMAN with the residue 466 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014367 name: TIF1B_HUMAN-Phosphoserine471 def: "Protein TIF1B_HUMAN with the residue 471 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014368 name: TIF1B_HUMAN-Phosphoserine473 def: "Protein TIF1B_HUMAN with the residue 473 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014369 name: TIF1B_HUMAN-Phosphoserine501 def: "Protein TIF1B_HUMAN with the residue 501 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014370 name: TIF1B_HUMAN-Phosphothreonine541 def: "Protein TIF1B_HUMAN with the residue 541 substituted with Phosphothreonine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014371 name: TIF1B_HUMAN-Phosphoserine594 def: "Protein TIF1B_HUMAN with the residue 594 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014372 name: TIF1B_HUMAN-Phosphoserine681 def: "Protein TIF1B_HUMAN with the residue 681 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014373 name: TIF1B_HUMAN-Phosphoserine683 def: "Protein TIF1B_HUMAN with the residue 683 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014374 name: TIF1B_HUMAN-Phosphoserine757 def: "Protein TIF1B_HUMAN with the residue 757 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014375 name: TIF1B_HUMAN-Phosphoserine824 def: "Protein TIF1B_HUMAN with the residue 824 substituted with Phosphoserine" [UniProtKB:Q13263] xref: UniProtKB:Q13263 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:B0014376 name: TIM_HUMAN-Phosphothreonine1089 def: "Protein TIM_HUMAN with the residue 1089 substituted with Phosphothreonine" [UniProtKB:Q9UNS1] xref: UniProtKB:Q9UNS1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002235 ! TIM_HUMAN [Term] id: CCO:B0014377 name: TIM_HUMAN-Phosphoserine1173 def: "Protein TIM_HUMAN with the residue 1173 substituted with Phosphoserine" [UniProtKB:Q9UNS1] xref: UniProtKB:Q9UNS1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002235 ! TIM_HUMAN [Term] id: CCO:B0014378 name: TIP60_HUMAN-Phosphoserine86 def: "Protein TIP60_HUMAN with the residue 86 substituted with Phosphoserine" [UniProtKB:Q92993] xref: UniProtKB:Q92993 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005351 ! TIP60_HUMAN [Term] id: CCO:B0014379 name: TIP60_HUMAN-Phosphoserine90 def: "Protein TIP60_HUMAN with the residue 90 substituted with Phosphoserine" [UniProtKB:Q92993] comment: by CDC2; xref: UniProtKB:Q92993 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005351 ! TIP60_HUMAN [Term] id: CCO:B0014380 name: TIPIN_HUMAN-Phosphoserine222 def: "Protein TIPIN_HUMAN with the residue 222 substituted with Phosphoserine" [UniProtKB:Q9BVW5] xref: UniProtKB:Q9BVW5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002104 ! TIPIN_HUMAN [Term] id: CCO:B0014381 name: TITIN_HUMAN-Phosphoserine33938 def: "Protein TITIN_HUMAN with the residue 33938 substituted with Phosphoserine" [UniProtKB:Q8WZ42] xref: UniProtKB:Q8WZ42 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:B0014382 name: TITIN_HUMAN-Phosphoserine33942 def: "Protein TITIN_HUMAN with the residue 33942 substituted with Phosphoserine" [UniProtKB:Q8WZ42] xref: UniProtKB:Q8WZ42 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:B0014383 name: TITIN_HUMAN-Phosphoserine9203 def: "Protein TITIN_HUMAN with the residue 9203 substituted with Phosphoserine" [UniProtKB:Q8WZ42] xref: UniProtKB:Q8WZ42 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:B0014384 name: TITIN_HUMAN-Phosphothreonine9207 def: "Protein TITIN_HUMAN with the residue 9207 substituted with Phosphothreonine" [UniProtKB:Q8WZ42] xref: UniProtKB:Q8WZ42 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:B0014385 name: TITIN_HUMAN-Phosphoserine22525 def: "Protein TITIN_HUMAN with the residue 22525 substituted with Phosphoserine" [UniProtKB:Q8WZ42] xref: UniProtKB:Q8WZ42 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:B0014386 name: TITIN_HUMAN-Phosphoserine22534 def: "Protein TITIN_HUMAN with the residue 22534 substituted with Phosphoserine" [UniProtKB:Q8WZ42] xref: UniProtKB:Q8WZ42 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:B0014387 name: TITIN_HUMAN-Phosphotyrosine32341 def: "Protein TITIN_HUMAN with the residue 32341 substituted with Phosphotyrosine" [UniProtKB:Q8WZ42] xref: UniProtKB:Q8WZ42 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:B0014389 name: TLE1_HUMAN-Phosphoserine239 def: "Protein TLE1_HUMAN with the residue 239 substituted with Phosphoserine" [UniProtKB:Q04724] comment: by CK2; Potential xref: UniProtKB:Q04724 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:B0014390 name: TLE1_HUMAN-Phosphoserine259 def: "Protein TLE1_HUMAN with the residue 259 substituted with Phosphoserine" [UniProtKB:Q04724] comment: by CDC2; Potential xref: UniProtKB:Q04724 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:B0014391 name: TLE1_HUMAN-Phosphoserine263 def: "Protein TLE1_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:Q04724] comment: by CDC2; Potential xref: UniProtKB:Q04724 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:B0014392 name: TLE1_HUMAN-Phosphoserine267 def: "Protein TLE1_HUMAN with the residue 267 substituted with Phosphoserine" [UniProtKB:Q04724] comment: by CDC2; Potential xref: UniProtKB:Q04724 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:B0014393 name: TLE1_HUMAN-Phosphoserine284 def: "Protein TLE1_HUMAN with the residue 284 substituted with Phosphoserine" [UniProtKB:Q04724] comment: By similarity xref: UniProtKB:Q04724 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:B0014394 name: TLE2_HUMAN-Phosphoserine228 def: "Protein TLE2_HUMAN with the residue 228 substituted with Phosphoserine" [UniProtKB:Q04725] comment: by CK2; Potential xref: UniProtKB:Q04725 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005657 ! TLE2_HUMAN [Term] id: CCO:B0014395 name: TLE2_HUMAN-Phosphoserine249 def: "Protein TLE2_HUMAN with the residue 249 substituted with Phosphoserine" [UniProtKB:Q04725] comment: by CDC2; Potential xref: UniProtKB:Q04725 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005657 ! TLE2_HUMAN [Term] id: CCO:B0014396 name: TLE2_HUMAN-Phosphothreonine253 def: "Protein TLE2_HUMAN with the residue 253 substituted with Phosphothreonine" [UniProtKB:Q04725] comment: by CDC2; Potential xref: UniProtKB:Q04725 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005657 ! TLE2_HUMAN [Term] id: CCO:B0014397 name: TLE3_HUMAN-Phosphoserine201 def: "Protein TLE3_HUMAN with the residue 201 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014398 name: TLE3_HUMAN-Phosphoserine203 def: "Protein TLE3_HUMAN with the residue 203 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014399 name: TLE3_HUMAN-Phosphoserine207 def: "Protein TLE3_HUMAN with the residue 207 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014400 name: TLE3_HUMAN-Phosphoserine217 def: "Protein TLE3_HUMAN with the residue 217 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014401 name: TLE3_HUMAN-Phosphoserine240 def: "Protein TLE3_HUMAN with the residue 240 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014402 name: TLE3_HUMAN-Phosphoserine245 def: "Protein TLE3_HUMAN with the residue 245 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014403 name: TLE3_HUMAN-Phosphothreonine259 def: "Protein TLE3_HUMAN with the residue 259 substituted with Phosphothreonine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014404 name: TLE3_HUMAN-Phosphoserine263 def: "Protein TLE3_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014405 name: TLE3_HUMAN-Phosphoserine267 def: "Protein TLE3_HUMAN with the residue 267 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014406 name: TLE3_HUMAN-Phosphoserine286 def: "Protein TLE3_HUMAN with the residue 286 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014407 name: TLE3_HUMAN-Phosphothreonine328 def: "Protein TLE3_HUMAN with the residue 328 substituted with Phosphothreonine" [UniProtKB:Q04726] comment: By similarity xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014408 name: TLE3_HUMAN-Phosphothreonine334 def: "Protein TLE3_HUMAN with the residue 334 substituted with Phosphothreonine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0014409 name: TLK1_HUMAN-Phosphoserine159 def: "Protein TLK1_HUMAN with the residue 159 substituted with Phosphoserine" [UniProtKB:Q9UKI8] xref: UniProtKB:Q9UKI8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002220 ! TLK1_HUMAN [Term] id: CCO:B0014410 name: TLK1_HUMAN-Phosphothreonine179 def: "Protein TLK1_HUMAN with the residue 179 substituted with Phosphothreonine" [UniProtKB:Q9UKI8] xref: UniProtKB:Q9UKI8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002220 ! TLK1_HUMAN [Term] id: CCO:B0014411 name: TLK1_HUMAN-Phosphoserine190 def: "Protein TLK1_HUMAN with the residue 190 substituted with Phosphoserine" [UniProtKB:Q9UKI8] xref: UniProtKB:Q9UKI8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002220 ! TLK1_HUMAN [Term] id: CCO:B0014412 name: TLK1_HUMAN-Phosphoserine743 def: "Protein TLK1_HUMAN with the residue 743 substituted with Phosphoserine" [UniProtKB:Q9UKI8] xref: UniProtKB:Q9UKI8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002220 ! TLK1_HUMAN [Term] id: CCO:B0014413 name: TLK2_HUMAN-Phosphoserine99 def: "Protein TLK2_HUMAN with the residue 99 substituted with Phosphoserine" [UniProtKB:Q86UE8] xref: UniProtKB:Q86UE8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: transformation_of CCO:B0001939 ! TLK2_HUMAN [Term] id: CCO:B0014414 name: TLK2_HUMAN-Phosphoserine750 def: "Protein TLK2_HUMAN with the residue 750 substituted with Phosphoserine" [UniProtKB:Q86UE8] comment: By similarity xref: UniProtKB:Q86UE8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001939 ! TLK2_HUMAN [Term] id: CCO:B0014415 name: TM1L1_HUMAN-Phosphoserine314 def: "Protein TM1L1_HUMAN with the residue 314 substituted with Phosphoserine" [UniProtKB:O75674] xref: UniProtKB:O75674 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006203 ! TM1L1_HUMAN [Term] id: CCO:B0014416 name: TM1L1_HUMAN-Phosphoserine323 def: "Protein TM1L1_HUMAN with the residue 323 substituted with Phosphoserine" [UniProtKB:O75674] xref: UniProtKB:O75674 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006203 ! TM1L1_HUMAN [Term] id: CCO:B0014417 name: TM1L1_HUMAN-Phosphotyrosine460 def: "Protein TM1L1_HUMAN with the residue 460 substituted with Phosphotyrosine" [UniProtKB:O75674] comment: By similarity xref: UniProtKB:O75674 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006203 ! TM1L1_HUMAN [Term] id: CCO:B0014418 name: TMF1_HUMAN-Phosphoserine72 def: "Protein TMF1_HUMAN with the residue 72 substituted with Phosphoserine" [UniProtKB:P82094] xref: UniProtKB:P82094 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005984 ! TMF1_HUMAN [Term] id: CCO:B0014419 name: TMF1_HUMAN-Phosphoserine77 def: "Protein TMF1_HUMAN with the residue 77 substituted with Phosphoserine" [UniProtKB:P82094] xref: UniProtKB:P82094 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005984 ! TMF1_HUMAN [Term] id: CCO:B0014421 name: TNIK_HUMAN-Phosphoserine680 def: "Protein TNIK_HUMAN with the residue 680 substituted with Phosphoserine" [UniProtKB:Q9UKE5] xref: UniProtKB:Q9UKE5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005603 ! TNIK_HUMAN [Term] id: CCO:B0014422 name: TNIK_HUMAN-Phosphoserine764 def: "Protein TNIK_HUMAN with the residue 764 substituted with Phosphoserine" [UniProtKB:Q9UKE5] xref: UniProtKB:Q9UKE5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005603 ! TNIK_HUMAN [Term] id: CCO:B0014423 name: TNIK_HUMAN-Phosphoserine769 def: "Protein TNIK_HUMAN with the residue 769 substituted with Phosphoserine" [UniProtKB:Q9UKE5] xref: UniProtKB:Q9UKE5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005603 ! TNIK_HUMAN [Term] id: CCO:B0014424 name: TNIK_HUMAN-Phosphothreonine987 def: "Protein TNIK_HUMAN with the residue 987 substituted with Phosphothreonine" [UniProtKB:Q9UKE5] comment: By similarity xref: UniProtKB:Q9UKE5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005603 ! TNIK_HUMAN [Term] id: CCO:B0014448 name: TOPK_HUMAN-Phosphoserine59 def: "Protein TOPK_HUMAN with the residue 59 substituted with Phosphoserine" [UniProtKB:Q96KB5] xref: UniProtKB:Q96KB5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002045 ! TOPK_HUMAN [Term] id: CCO:B0014449 name: TOPK_HUMAN-Phosphothreonine200 def: "Protein TOPK_HUMAN with the residue 200 substituted with Phosphothreonine" [UniProtKB:Q96KB5] comment: By similarity xref: UniProtKB:Q96KB5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002045 ! TOPK_HUMAN [Term] id: CCO:B0014450 name: TP53B_HUMAN-Phosphoserine105 def: "Protein TP53B_HUMAN with the residue 105 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014451 name: TP53B_HUMAN-Phosphoserine294 def: "Protein TP53B_HUMAN with the residue 294 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014452 name: TP53B_HUMAN-Phosphothreonine302 def: "Protein TP53B_HUMAN with the residue 302 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014453 name: TP53B_HUMAN-Phosphoserine316 def: "Protein TP53B_HUMAN with the residue 316 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014454 name: TP53B_HUMAN-Phosphoserine380 def: "Protein TP53B_HUMAN with the residue 380 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014455 name: TP53B_HUMAN-Phosphoserine500 def: "Protein TP53B_HUMAN with the residue 500 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014456 name: TP53B_HUMAN-Phosphoserine523 def: "Protein TP53B_HUMAN with the residue 523 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014457 name: TP53B_HUMAN-Phosphoserine525 def: "Protein TP53B_HUMAN with the residue 525 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014458 name: TP53B_HUMAN-Phosphothreonine543 def: "Protein TP53B_HUMAN with the residue 543 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014459 name: TP53B_HUMAN-Phosphothreonine548 def: "Protein TP53B_HUMAN with the residue 548 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014460 name: TP53B_HUMAN-Phosphoserine552 def: "Protein TP53B_HUMAN with the residue 552 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014461 name: TP53B_HUMAN-Phosphoserine566 def: "Protein TP53B_HUMAN with the residue 566 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014462 name: TP53B_HUMAN-Phosphoserine580 def: "Protein TP53B_HUMAN with the residue 580 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014463 name: TP53B_HUMAN-Phosphoserine625 def: "Protein TP53B_HUMAN with the residue 625 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014464 name: TP53B_HUMAN-Phosphoserine635 def: "Protein TP53B_HUMAN with the residue 635 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014465 name: TP53B_HUMAN-Phosphoserine639 def: "Protein TP53B_HUMAN with the residue 639 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014466 name: TP53B_HUMAN-Phosphoserine640 def: "Protein TP53B_HUMAN with the residue 640 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014467 name: TP53B_HUMAN-Phosphoserine659 def: "Protein TP53B_HUMAN with the residue 659 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014468 name: TP53B_HUMAN-Phosphoserine660 def: "Protein TP53B_HUMAN with the residue 660 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014469 name: TP53B_HUMAN-Phosphoserine662 def: "Protein TP53B_HUMAN with the residue 662 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014470 name: TP53B_HUMAN-Phosphothreonine750 def: "Protein TP53B_HUMAN with the residue 750 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014471 name: TP53B_HUMAN-Phosphoserine751 def: "Protein TP53B_HUMAN with the residue 751 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014472 name: TP53B_HUMAN-Phosphoserine754 def: "Protein TP53B_HUMAN with the residue 754 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014473 name: TP53B_HUMAN-Phosphoserine755 def: "Protein TP53B_HUMAN with the residue 755 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014474 name: TP53B_HUMAN-Phosphoserine771 def: "Protein TP53B_HUMAN with the residue 771 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014475 name: TP53B_HUMAN-Phosphoserine782 def: "Protein TP53B_HUMAN with the residue 782 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014476 name: TP53B_HUMAN-Phosphoserine784 def: "Protein TP53B_HUMAN with the residue 784 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014477 name: TP53B_HUMAN-Phosphoserine831 def: "Protein TP53B_HUMAN with the residue 831 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014478 name: TP53B_HUMAN-Phosphothreonine855 def: "Protein TP53B_HUMAN with the residue 855 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014479 name: TP53B_HUMAN-Phosphoserine892 def: "Protein TP53B_HUMAN with the residue 892 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014480 name: TP53B_HUMAN-Phosphoserine993 def: "Protein TP53B_HUMAN with the residue 993 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014481 name: TP53B_HUMAN-Phosphothreonine996 def: "Protein TP53B_HUMAN with the residue 996 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014482 name: TP53B_HUMAN-Phosphoserine999 def: "Protein TP53B_HUMAN with the residue 999 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014483 name: TP53B_HUMAN-Phosphoserine1002 def: "Protein TP53B_HUMAN with the residue 1002 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014484 name: TP53B_HUMAN-Phosphoserine1028 def: "Protein TP53B_HUMAN with the residue 1028 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014485 name: TP53B_HUMAN-Phosphothreonine1056 def: "Protein TP53B_HUMAN with the residue 1056 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014486 name: TP53B_HUMAN-Phosphoserine1068 def: "Protein TP53B_HUMAN with the residue 1068 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014487 name: TP53B_HUMAN-Phosphoserine1094 def: "Protein TP53B_HUMAN with the residue 1094 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014488 name: TP53B_HUMAN-Phosphoserine1104 def: "Protein TP53B_HUMAN with the residue 1104 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014489 name: TP53B_HUMAN-Phosphoserine1114 def: "Protein TP53B_HUMAN with the residue 1114 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014490 name: TP53B_HUMAN-Phosphothreonine1171 def: "Protein TP53B_HUMAN with the residue 1171 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014491 name: TP53B_HUMAN-Phosphothreonine1214 def: "Protein TP53B_HUMAN with the residue 1214 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014492 name: TP53B_HUMAN-Phosphoserine1216 def: "Protein TP53B_HUMAN with the residue 1216 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014493 name: TP53B_HUMAN-Phosphoserine1219 def: "Protein TP53B_HUMAN with the residue 1219 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014494 name: TP53B_HUMAN-Phosphoserine1290 def: "Protein TP53B_HUMAN with the residue 1290 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014495 name: TP53B_HUMAN-Phosphoserine1316 def: "Protein TP53B_HUMAN with the residue 1316 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014496 name: TP53B_HUMAN-Phosphoserine1317 def: "Protein TP53B_HUMAN with the residue 1317 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014497 name: TP53B_HUMAN-Phosphoserine1320 def: "Protein TP53B_HUMAN with the residue 1320 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014498 name: TP53B_HUMAN-Phosphoserine1362 def: "Protein TP53B_HUMAN with the residue 1362 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014499 name: TP53B_HUMAN-Phosphoserine1426 def: "Protein TP53B_HUMAN with the residue 1426 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014500 name: TP53B_HUMAN-Phosphoserine1430 def: "Protein TP53B_HUMAN with the residue 1430 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014501 name: TP53B_HUMAN-Phosphoserine1631 def: "Protein TP53B_HUMAN with the residue 1631 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014502 name: TP53B_HUMAN-Phosphoserine1634 def: "Protein TP53B_HUMAN with the residue 1634 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014503 name: TP53B_HUMAN-Phosphoserine1635 def: "Protein TP53B_HUMAN with the residue 1635 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014504 name: TP53B_HUMAN-Phosphothreonine1638 def: "Protein TP53B_HUMAN with the residue 1638 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014505 name: TP53B_HUMAN-Phosphothreonine1647 def: "Protein TP53B_HUMAN with the residue 1647 substituted with Phosphothreonine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014506 name: TP53B_HUMAN-Phosphoserine1673 def: "Protein TP53B_HUMAN with the residue 1673 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014507 name: TP53B_HUMAN-Phosphoserine1678 def: "Protein TP53B_HUMAN with the residue 1678 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014508 name: TP53B_HUMAN-Phosphoserine1701 def: "Protein TP53B_HUMAN with the residue 1701 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014509 name: TP53B_HUMAN-Phosphoserine1705 def: "Protein TP53B_HUMAN with the residue 1705 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0014510 name: TPD52_HUMAN-Phosphoserine131 def: "Protein TPD52_HUMAN with the residue 131 substituted with Phosphoserine" [UniProtKB:P55327] xref: UniProtKB:P55327 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005373 ! TPD52_HUMAN [Term] id: CCO:B0014511 name: TPD52_HUMAN-Phosphothreonine133 def: "Protein TPD52_HUMAN with the residue 133 substituted with Phosphothreonine" [UniProtKB:P55327] xref: UniProtKB:P55327 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005373 ! TPD52_HUMAN [Term] id: CCO:B0014512 name: TPD52_HUMAN-Phosphoserine136 def: "Protein TPD52_HUMAN with the residue 136 substituted with Phosphoserine" [UniProtKB:P55327] xref: UniProtKB:P55327 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005373 ! TPD52_HUMAN [Term] id: CCO:B0014513 name: TPX2_HUMAN-Phosphothreonine51 def: "Protein TPX2_HUMAN with the residue 51 substituted with Phosphothreonine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014514 name: TPX2_HUMAN-Phosphothreonine72 def: "Protein TPX2_HUMAN with the residue 72 substituted with Phosphothreonine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014515 name: TPX2_HUMAN-Phosphoserine121 def: "Protein TPX2_HUMAN with the residue 121 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014516 name: TPX2_HUMAN-Phosphoserine125 def: "Protein TPX2_HUMAN with the residue 125 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014517 name: TPX2_HUMAN-Phosphothreonine147 def: "Protein TPX2_HUMAN with the residue 147 substituted with Phosphothreonine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014518 name: TPX2_HUMAN-Phosphoserine186 def: "Protein TPX2_HUMAN with the residue 186 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014519 name: TPX2_HUMAN-Phosphoserine293 def: "Protein TPX2_HUMAN with the residue 293 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014520 name: TPX2_HUMAN-Phosphothreonine338 def: "Protein TPX2_HUMAN with the residue 338 substituted with Phosphothreonine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014521 name: TPX2_HUMAN-Phosphoserine359 def: "Protein TPX2_HUMAN with the residue 359 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014522 name: TPX2_HUMAN-Phosphothreonine369 def: "Protein TPX2_HUMAN with the residue 369 substituted with Phosphothreonine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014523 name: TPX2_HUMAN-Phosphothreonine374 def: "Protein TPX2_HUMAN with the residue 374 substituted with Phosphothreonine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014524 name: TPX2_HUMAN-Phosphoserine486 def: "Protein TPX2_HUMAN with the residue 486 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014525 name: TPX2_HUMAN-Phosphoserine542 def: "Protein TPX2_HUMAN with the residue 542 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014526 name: TPX2_HUMAN-Phosphoserine634 def: "Protein TPX2_HUMAN with the residue 634 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014527 name: TPX2_HUMAN-Phosphoserine652 def: "Protein TPX2_HUMAN with the residue 652 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014528 name: TPX2_HUMAN-Phosphoserine654 def: "Protein TPX2_HUMAN with the residue 654 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014529 name: TPX2_HUMAN-Phosphoserine738 def: "Protein TPX2_HUMAN with the residue 738 substituted with Phosphoserine" [UniProtKB:Q9ULW0] xref: UniProtKB:Q9ULW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:B0014531 name: TRI29_HUMAN-Phosphoserine58 def: "Protein TRI29_HUMAN with the residue 58 substituted with Phosphoserine" [UniProtKB:Q14134] xref: UniProtKB:Q14134 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005204 ! TRI29_HUMAN [Term] id: CCO:B0014532 name: TRI29_HUMAN-Phosphoserine104 def: "Protein TRI29_HUMAN with the residue 104 substituted with Phosphoserine" [UniProtKB:Q14134] xref: UniProtKB:Q14134 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005204 ! TRI29_HUMAN [Term] id: CCO:B0014533 name: TRI29_HUMAN-Phosphoserine489 def: "Protein TRI29_HUMAN with the residue 489 substituted with Phosphoserine" [UniProtKB:Q14134] xref: UniProtKB:Q14134 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005204 ! TRI29_HUMAN [Term] id: CCO:B0014534 name: TRI37_HUMAN-Phosphoserine771 def: "Protein TRI37_HUMAN with the residue 771 substituted with Phosphoserine" [UniProtKB:O94972] xref: UniProtKB:O94972 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005249 ! TRI37_HUMAN [Term] id: CCO:B0014535 name: TRI37_HUMAN-Phosphoserine773 def: "Protein TRI37_HUMAN with the residue 773 substituted with Phosphoserine" [UniProtKB:O94972] xref: UniProtKB:O94972 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005249 ! TRI37_HUMAN [Term] id: CCO:B0014536 name: TRIP6_HUMAN-Phosphoserine92 def: "Protein TRIP6_HUMAN with the residue 92 substituted with Phosphoserine" [UniProtKB:Q15654] xref: UniProtKB:Q15654 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005985 ! TRIP6_HUMAN [Term] id: CCO:B0014537 name: TRP13_HUMAN-Phosphotyrosine56 def: "Protein TRP13_HUMAN with the residue 56 substituted with Phosphotyrosine" [UniProtKB:Q15645] xref: UniProtKB:Q15645 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006283 ! TRP13_HUMAN [Term] id: CCO:B0014538 name: TRRAP_HUMAN-Phosphoserine2051 def: "Protein TRRAP_HUMAN with the residue 2051 substituted with Phosphoserine" [UniProtKB:Q9Y4A5] xref: UniProtKB:Q9Y4A5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005350 ! TRRAP_HUMAN [Term] id: CCO:B0014539 name: TRRAP_HUMAN-Phosphoserine2077 def: "Protein TRRAP_HUMAN with the residue 2077 substituted with Phosphoserine" [UniProtKB:Q9Y4A5] comment: By similarity xref: UniProtKB:Q9Y4A5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005350 ! TRRAP_HUMAN [Term] id: CCO:B0014540 name: TSC1_HUMAN-Phosphoserine505 def: "Protein TSC1_HUMAN with the residue 505 substituted with Phosphoserine" [UniProtKB:Q92574] xref: UniProtKB:Q92574 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0006791 ! protein N-terminus binding relationship: has_function CCO:F0008056 ! chaperone binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000244 ! membrane fraction relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0000442 ! actin filament relationship: located_in CCO:C0000489 ! cell cortex relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000935 ! lamellipodium relationship: located_in CCO:C0001584 ! TSC1-TSC2 complex relationship: located_in CCO:C0001750 ! protein complex relationship: transformation_of CCO:B0002014 ! TSC1_HUMAN [Term] id: CCO:B0014541 name: TSC1_HUMAN-Phosphoserine1102 def: "Protein TSC1_HUMAN with the residue 1102 substituted with Phosphoserine" [UniProtKB:Q92574] xref: UniProtKB:Q92574 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002014 ! TSC1_HUMAN [Term] id: CCO:B0014542 name: TSC2_HUMAN-Phosphoserine981 def: "Protein TSC2_HUMAN with the residue 981 substituted with Phosphoserine" [UniProtKB:P49815] comment: By similarity xref: UniProtKB:P49815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001637 ! TSC2_HUMAN [Term] id: CCO:B0014543 name: TSC2_HUMAN-Phosphoserine1364 def: "Protein TSC2_HUMAN with the residue 1364 substituted with Phosphoserine" [UniProtKB:P49815] comment: By similarity xref: UniProtKB:P49815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001637 ! TSC2_HUMAN [Term] id: CCO:B0014544 name: TSC2_HUMAN-Phosphoserine1387 def: "Protein TSC2_HUMAN with the residue 1387 substituted with Phosphoserine" [UniProtKB:P49815] xref: UniProtKB:P49815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001637 ! TSC2_HUMAN [Term] id: CCO:B0014545 name: TSC2_HUMAN-Phosphoserine1411 def: "Protein TSC2_HUMAN with the residue 1411 substituted with Phosphoserine" [UniProtKB:P49815] xref: UniProtKB:P49815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001637 ! TSC2_HUMAN [Term] id: CCO:B0014546 name: TSC2_HUMAN-Phosphoserine1418 def: "Protein TSC2_HUMAN with the residue 1418 substituted with Phosphoserine" [UniProtKB:P49815] xref: UniProtKB:P49815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001637 ! TSC2_HUMAN [Term] id: CCO:B0014547 name: TSC2_HUMAN-Phosphoserine1420 def: "Protein TSC2_HUMAN with the residue 1420 substituted with Phosphoserine" [UniProtKB:P49815] xref: UniProtKB:P49815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001637 ! TSC2_HUMAN [Term] id: CCO:B0014548 name: TSC2_HUMAN-Phosphoserine1798 def: "Protein TSC2_HUMAN with the residue 1798 substituted with Phosphoserine" [UniProtKB:P49815] xref: UniProtKB:P49815 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001637 ! TSC2_HUMAN [Term] id: CCO:B0014549 name: TSYL2_HUMAN-Phosphoserine16 def: "Protein TSYL2_HUMAN with the residue 16 substituted with Phosphoserine" [UniProtKB:Q9H2G4] xref: UniProtKB:Q9H2G4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000036 ! rDNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000320 ! nucleolus relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0002128 ! TSYL2_HUMAN [Term] id: CCO:B0014550 name: TSYL2_HUMAN-Phosphoserine17 def: "Protein TSYL2_HUMAN with the residue 17 substituted with Phosphoserine" [UniProtKB:Q9H2G4] xref: UniProtKB:Q9H2G4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002128 ! TSYL2_HUMAN [Term] id: CCO:B0014551 name: TSYL2_HUMAN-Phosphoserine20 def: "Protein TSYL2_HUMAN with the residue 20 substituted with Phosphoserine" [UniProtKB:Q9H2G4] comment: Probable xref: UniProtKB:Q9H2G4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002128 ! TSYL2_HUMAN [Term] id: CCO:B0014552 name: TSYL2_HUMAN-Phosphothreonine340 def: "Protein TSYL2_HUMAN with the residue 340 substituted with Phosphothreonine" [UniProtKB:Q9H2G4] comment: Probable xref: UniProtKB:Q9H2G4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002128 ! TSYL2_HUMAN [Term] id: CCO:B0014553 name: TTK_HUMAN-Phosphoserine821 def: "Protein TTK_HUMAN with the residue 821 substituted with Phosphoserine" [UniProtKB:P33981] xref: UniProtKB:P33981 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001587 ! TTK_HUMAN [Term] id: CCO:B0014554 name: TTK_HUMAN-Phosphoserine824 def: "Protein TTK_HUMAN with the residue 824 substituted with Phosphoserine" [UniProtKB:P33981] xref: UniProtKB:P33981 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001587 ! TTK_HUMAN [Term] id: CCO:B0014555 name: TTLL5_HUMAN-Phosphothreonine515 def: "Protein TTLL5_HUMAN with the residue 515 substituted with Phosphothreonine" [UniProtKB:Q6EMB2] xref: UniProtKB:Q6EMB2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006333 ! TTLL5_HUMAN [Term] id: CCO:B0014556 name: TUSC2_HUMAN-Phosphoserine50 def: "Protein TUSC2_HUMAN with the residue 50 substituted with Phosphoserine" [UniProtKB:O75896] comment: By similarity xref: UniProtKB:O75896 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001438 ! TUSC2_HUMAN [Term] id: CCO:B0014557 name: TYB4_HUMAN-N-acetylserine2 def: "Protein TYB4_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P62328] xref: UniProtKB:P62328 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006115 ! TYB4_HUMAN [Term] id: CCO:B0014558 name: TYB4_HUMAN-Phosphothreonine23 def: "Protein TYB4_HUMAN with the residue 23 substituted with Phosphothreonine" [UniProtKB:P62328] comment: By similarity xref: UniProtKB:P62328 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006115 ! TYB4_HUMAN [Term] id: CCO:B0014559 name: TYY1_HUMAN-Phosphoserine118 def: "Protein TYY1_HUMAN with the residue 118 substituted with Phosphoserine" [UniProtKB:P25490] xref: UniProtKB:P25490 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006011 ! TYY1_HUMAN [Term] id: CCO:B0014560 name: TYY1_HUMAN-Phosphoserine184 def: "Protein TYY1_HUMAN with the residue 184 substituted with Phosphoserine" [UniProtKB:P25490] xref: UniProtKB:P25490 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006011 ! TYY1_HUMAN [Term] id: CCO:B0014561 name: TYY1_HUMAN-Phosphoserine247 def: "Protein TYY1_HUMAN with the residue 247 substituted with Phosphoserine" [UniProtKB:P25490] xref: UniProtKB:P25490 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006011 ! TYY1_HUMAN [Term] id: CCO:B0014562 name: TYY1_HUMAN-Phosphothreonine348 def: "Protein TYY1_HUMAN with the residue 348 substituted with Phosphothreonine" [UniProtKB:P25490] xref: UniProtKB:P25490 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006011 ! TYY1_HUMAN [Term] id: CCO:B0014563 name: UB2R1_HUMAN-Phosphoserine231 def: "Protein UB2R1_HUMAN with the residue 231 substituted with Phosphoserine" [UniProtKB:P49427] comment: by CK2; Probable xref: UniProtKB:P49427 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001628 ! UB2R1_HUMAN [Term] id: CCO:B0014564 name: UBE3A_HUMAN-Phosphoserine218 def: "Protein UBE3A_HUMAN with the residue 218 substituted with Phosphoserine" [UniProtKB:Q05086] xref: UniProtKB:Q05086 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005334 ! UBE3A_HUMAN [Term] id: CCO:B0014565 name: UBIQ_HUMAN-Phosphoserine57 def: "Protein UBIQ_HUMAN with the residue 57 substituted with Phosphoserine" [UniProtKB:P62988] comment: By similarity xref: UniProtKB:P62988 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001695 ! UBIQ_HUMAN [Term] id: CCO:B0014566 name: UBIQ_HUMAN-Phosphoserine65 def: "Protein UBIQ_HUMAN with the residue 65 substituted with Phosphoserine" [UniProtKB:P62988] xref: UniProtKB:P62988 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001695 ! UBIQ_HUMAN [Term] id: CCO:B0014567 name: UBP16_HUMAN-Phosphoserine552 def: "Protein UBP16_HUMAN with the residue 552 substituted with Phosphoserine" [UniProtKB:Q9Y5T5] xref: UniProtKB:Q9Y5T5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002259 ! UBP16_HUMAN [Term] id: CCO:B0014570 name: UBP7_HUMAN-Phosphoserine18 def: "Protein UBP7_HUMAN with the residue 18 substituted with Phosphoserine" [UniProtKB:Q93009] xref: UniProtKB:Q93009 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:B0014571 name: UBQL4_HUMAN-Phosphoserine318 def: "Protein UBQL4_HUMAN with the residue 318 substituted with Phosphoserine" [UniProtKB:Q9NRR5] xref: UniProtKB:Q9NRR5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005619 ! UBQL4_HUMAN [Term] id: CCO:B0014572 name: UBR1_HUMAN-Phosphothreonine21 def: "Protein UBR1_HUMAN with the residue 21 substituted with Phosphothreonine" [UniProtKB:Q8IWV7] xref: UniProtKB:Q8IWV7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006135 ! UBR1_HUMAN [Term] id: CCO:B0014573 name: UBR1_HUMAN-Phosphoserine1179 def: "Protein UBR1_HUMAN with the residue 1179 substituted with Phosphoserine" [UniProtKB:Q8IWV7] xref: UniProtKB:Q8IWV7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006135 ! UBR1_HUMAN [Term] id: CCO:B0014577 name: UHRF1_HUMAN-Phosphoserine287 def: "Protein UHRF1_HUMAN with the residue 287 substituted with Phosphoserine" [UniProtKB:Q96T88] xref: UniProtKB:Q96T88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002063 ! UHRF1_HUMAN [Term] id: CCO:B0014578 name: UHRF1_HUMAN-Phosphoserine298 def: "Protein UHRF1_HUMAN with the residue 298 substituted with Phosphoserine" [UniProtKB:Q96T88] comment: by PKA; in vitro; xref: UniProtKB:Q96T88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002063 ! UHRF1_HUMAN [Term] id: CCO:B0014579 name: UHRF1_HUMAN-Phosphoserine639 def: "Protein UHRF1_HUMAN with the residue 639 substituted with Phosphoserine" [UniProtKB:Q96T88] xref: UniProtKB:Q96T88 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002063 ! UHRF1_HUMAN [Term] id: CCO:B0014580 name: UN119_HUMAN-Phosphoserine37 def: "Protein UN119_HUMAN with the residue 37 substituted with Phosphoserine" [UniProtKB:Q13432] comment: By similarity xref: UniProtKB:Q13432 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006080 ! UN119_HUMAN [Term] id: CCO:B0014581 name: UN84B_HUMAN-Phosphoserine12 def: "Protein UN84B_HUMAN with the residue 12 substituted with Phosphoserine" [UniProtKB:Q9UH99] xref: UniProtKB:Q9UH99 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002199 ! UN84B_HUMAN [Term] id: CCO:B0014582 name: UN84B_HUMAN-Phosphoserine38 def: "Protein UN84B_HUMAN with the residue 38 substituted with Phosphoserine" [UniProtKB:Q9UH99] comment: By similarity xref: UniProtKB:Q9UH99 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002199 ! UN84B_HUMAN [Term] id: CCO:B0014583 name: UN84B_HUMAN-Phosphoserine54 def: "Protein UN84B_HUMAN with the residue 54 substituted with Phosphoserine" [UniProtKB:Q9UH99] xref: UniProtKB:Q9UH99 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002199 ! UN84B_HUMAN [Term] id: CCO:B0014584 name: UN84B_HUMAN-Phosphoserine116 def: "Protein UN84B_HUMAN with the residue 116 substituted with Phosphoserine" [UniProtKB:Q9UH99] xref: UniProtKB:Q9UH99 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002199 ! UN84B_HUMAN [Term] id: CCO:B0014585 name: UT14A_HUMAN-Phosphoserine29 def: "Protein UT14A_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:Q9BVJ6] xref: UniProtKB:Q9BVJ6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:B0014586 name: UT14A_HUMAN-Phosphoserine31 def: "Protein UT14A_HUMAN with the residue 31 substituted with Phosphoserine" [UniProtKB:Q9BVJ6] xref: UniProtKB:Q9BVJ6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:B0014587 name: UT14A_HUMAN-Phosphoserine434 def: "Protein UT14A_HUMAN with the residue 434 substituted with Phosphoserine" [UniProtKB:Q9BVJ6] xref: UniProtKB:Q9BVJ6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:B0014588 name: UT14A_HUMAN-Phosphoserine437 def: "Protein UT14A_HUMAN with the residue 437 substituted with Phosphoserine" [UniProtKB:Q9BVJ6] xref: UniProtKB:Q9BVJ6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:B0014589 name: UT14A_HUMAN-Phosphoserine445 def: "Protein UT14A_HUMAN with the residue 445 substituted with Phosphoserine" [UniProtKB:Q9BVJ6] xref: UniProtKB:Q9BVJ6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:B0014590 name: UT14A_HUMAN-Phosphoserine451 def: "Protein UT14A_HUMAN with the residue 451 substituted with Phosphoserine" [UniProtKB:Q9BVJ6] xref: UniProtKB:Q9BVJ6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:B0014591 name: UT14A_HUMAN-Phosphoserine453 def: "Protein UT14A_HUMAN with the residue 453 substituted with Phosphoserine" [UniProtKB:Q9BVJ6] xref: UniProtKB:Q9BVJ6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:B0014592 name: VDAC1_HUMAN-N-acetylalanine2 def: "Protein VDAC1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P21796] xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0014593 name: VDAC1_HUMAN-Phosphoserine13 def: "Protein VDAC1_HUMAN with the residue 13 substituted with Phosphoserine" [UniProtKB:P21796] comment: By similarity xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0014594 name: VDAC1_HUMAN-N6-acetyllysine20 def: "Protein VDAC1_HUMAN with the residue 20 substituted with N6-acetyllysine" [UniProtKB:P21796] comment: By similarity xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0014595 name: VDAC1_HUMAN-N6-acetyllysine28 def: "Protein VDAC1_HUMAN with the residue 28 substituted with N6-acetyllysine" [UniProtKB:P21796] comment: By similarity xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0014596 name: VDAC1_HUMAN-N6-acetyllysine61 def: "Protein VDAC1_HUMAN with the residue 61 substituted with N6-acetyllysine" [UniProtKB:P21796] comment: By similarity xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0014597 name: VDAC1_HUMAN-Phosphoserine104 def: "Protein VDAC1_HUMAN with the residue 104 substituted with Phosphoserine" [UniProtKB:P21796] xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0014598 name: VDAC1_HUMAN-Phosphoserine137 def: "Protein VDAC1_HUMAN with the residue 137 substituted with Phosphoserine" [UniProtKB:P21796] comment: By similarity xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0014599 name: VDAC1_HUMAN-Phosphotyrosine195 def: "Protein VDAC1_HUMAN with the residue 195 substituted with Phosphotyrosine" [UniProtKB:P21796] xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0014600 name: VDAC1_HUMAN-N6-acetyllysine224 def: "Protein VDAC1_HUMAN with the residue 224 substituted with N6-acetyllysine" [UniProtKB:P21796] comment: By similarity xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0014601 name: VDAC2_HUMAN-N6-acetyllysine31 def: "Protein VDAC2_HUMAN with the residue 31 substituted with N6-acetyllysine" [UniProtKB:P45880] comment: By similarity xref: UniProtKB:P45880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005777 ! VDAC2_HUMAN [Term] id: CCO:B0014602 name: VDAC2_HUMAN-N6-acetyllysine74 def: "Protein VDAC2_HUMAN with the residue 74 substituted with N6-acetyllysine" [UniProtKB:P45880] comment: By similarity xref: UniProtKB:P45880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005777 ! VDAC2_HUMAN [Term] id: CCO:B0014603 name: VDAC2_HUMAN-Phosphoserine115 def: "Protein VDAC2_HUMAN with the residue 115 substituted with Phosphoserine" [UniProtKB:P45880] xref: UniProtKB:P45880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005777 ! VDAC2_HUMAN [Term] id: CCO:B0014604 name: VDAC2_HUMAN-Phosphotyrosine236 def: "Protein VDAC2_HUMAN with the residue 236 substituted with Phosphotyrosine" [UniProtKB:P45880] comment: By similarity xref: UniProtKB:P45880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005777 ! VDAC2_HUMAN [Term] id: CCO:B0014605 name: VDAC3_HUMAN-N6-acetyllysine20 def: "Protein VDAC3_HUMAN with the residue 20 substituted with N6-acetyllysine" [UniProtKB:Q9Y277] comment: By similarity xref: UniProtKB:Q9Y277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005738 ! VDAC3_HUMAN [Term] id: CCO:B0014606 name: VDAC3_HUMAN-Phosphothreonine33 def: "Protein VDAC3_HUMAN with the residue 33 substituted with Phosphothreonine" [UniProtKB:Q9Y277] comment: By similarity xref: UniProtKB:Q9Y277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005738 ! VDAC3_HUMAN [Term] id: CCO:B0014607 name: VDAC3_HUMAN-N6-acetyllysine61 def: "Protein VDAC3_HUMAN with the residue 61 substituted with N6-acetyllysine" [UniProtKB:Q9Y277] comment: By similarity xref: UniProtKB:Q9Y277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005738 ! VDAC3_HUMAN [Term] id: CCO:B0014608 name: VDAC3_HUMAN-Phosphotyrosine195 def: "Protein VDAC3_HUMAN with the residue 195 substituted with Phosphotyrosine" [UniProtKB:Q9Y277] xref: UniProtKB:Q9Y277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005738 ! VDAC3_HUMAN [Term] id: CCO:B0014609 name: VDAC3_HUMAN-Phosphoserine241 def: "Protein VDAC3_HUMAN with the residue 241 substituted with Phosphoserine" [UniProtKB:Q9Y277] comment: By similarity xref: UniProtKB:Q9Y277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005738 ! VDAC3_HUMAN [Term] id: CCO:B0014619 name: VIME_HUMAN-N-acetylserine2 def: "Protein VIME_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014620 name: VIME_HUMAN-Phosphoserine5 def: "Protein VIME_HUMAN with the residue 5 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014621 name: VIME_HUMAN-Phosphoserine7 def: "Protein VIME_HUMAN with the residue 7 substituted with Phosphoserine" [UniProtKB:P08670] comment: by PKA and PKC; xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014622 name: VIME_HUMAN-Phosphoserine8 def: "Protein VIME_HUMAN with the residue 8 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014623 name: VIME_HUMAN-Phosphoserine9 def: "Protein VIME_HUMAN with the residue 9 substituted with Phosphoserine" [UniProtKB:P08670] comment: by PKC; xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014624 name: VIME_HUMAN-Phosphoserine10 def: "Protein VIME_HUMAN with the residue 10 substituted with Phosphoserine" [UniProtKB:P08670] comment: by PKC; xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014625 name: VIME_HUMAN-Phosphoserine25 def: "Protein VIME_HUMAN with the residue 25 substituted with Phosphoserine" [UniProtKB:P08670] comment: by PKA and PKC; By similarity xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014626 name: VIME_HUMAN-Phosphoserine26 def: "Protein VIME_HUMAN with the residue 26 substituted with Phosphoserine" [UniProtKB:P08670] comment: by PKC; By similarity xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014627 name: VIME_HUMAN-Phosphoserine27 def: "Protein VIME_HUMAN with the residue 27 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014628 name: VIME_HUMAN-Phosphoserine34 def: "Protein VIME_HUMAN with the residue 34 substituted with Phosphoserine" [UniProtKB:P08670] comment: by PKC; By similarity xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014629 name: VIME_HUMAN-Phosphoserine39 def: "Protein VIME_HUMAN with the residue 39 substituted with Phosphoserine" [UniProtKB:P08670] comment: by CaMK2, PKA and PKC; xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014630 name: VIME_HUMAN-Phosphoserine42 def: "Protein VIME_HUMAN with the residue 42 substituted with Phosphoserine" [UniProtKB:P08670] comment: by PKC; xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014631 name: VIME_HUMAN-Phosphoserine47 def: "Protein VIME_HUMAN with the residue 47 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014632 name: VIME_HUMAN-Phosphoserine51 def: "Protein VIME_HUMAN with the residue 51 substituted with Phosphoserine" [UniProtKB:P08670] comment: by PKA and PKC; By similarity xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014633 name: VIME_HUMAN-Phosphoserine55 def: "Protein VIME_HUMAN with the residue 55 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014634 name: VIME_HUMAN-Phosphoserine56 def: "Protein VIME_HUMAN with the residue 56 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014635 name: VIME_HUMAN-Phosphotyrosine61 def: "Protein VIME_HUMAN with the residue 61 substituted with Phosphotyrosine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014636 name: VIME_HUMAN-Phosphoserine66 def: "Protein VIME_HUMAN with the residue 66 substituted with Phosphoserine" [UniProtKB:P08670] comment: by PKA and PKC; By similarity xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014637 name: VIME_HUMAN-Phosphoserine72 def: "Protein VIME_HUMAN with the residue 72 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014638 name: VIME_HUMAN-Phosphoserine73 def: "Protein VIME_HUMAN with the residue 73 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014639 name: VIME_HUMAN-Phosphoserine83 def: "Protein VIME_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:P08670] comment: by CaMK2; By similarity xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014640 name: VIME_HUMAN-Phosphotyrosine117 def: "Protein VIME_HUMAN with the residue 117 substituted with Phosphotyrosine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014641 name: VIME_HUMAN-Phosphoserine214 def: "Protein VIME_HUMAN with the residue 214 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014642 name: VIME_HUMAN-Phosphoserine412 def: "Protein VIME_HUMAN with the residue 412 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014643 name: VIME_HUMAN-Phosphoserine420 def: "Protein VIME_HUMAN with the residue 420 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014644 name: VIME_HUMAN-Phosphoserine430 def: "Protein VIME_HUMAN with the residue 430 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014645 name: VIME_HUMAN-Phosphothreonine446 def: "Protein VIME_HUMAN with the residue 446 substituted with Phosphothreonine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014646 name: VIME_HUMAN-Phosphothreonine458 def: "Protein VIME_HUMAN with the residue 458 substituted with Phosphothreonine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014647 name: VIME_HUMAN-Phosphoserine459 def: "Protein VIME_HUMAN with the residue 459 substituted with Phosphoserine" [UniProtKB:P08670] xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0014648 name: VPS72_HUMAN-Phosphothreonine168 def: "Protein VPS72_HUMAN with the residue 168 substituted with Phosphothreonine" [UniProtKB:Q15906] xref: UniProtKB:Q15906 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005361 ! VPS72_HUMAN [Term] id: CCO:B0014649 name: WAPL_HUMAN-Phosphoserine77 def: "Protein WAPL_HUMAN with the residue 77 substituted with Phosphoserine" [UniProtKB:Q7Z5K2] comment: By similarity xref: UniProtKB:Q7Z5K2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:B0014650 name: WAPL_HUMAN-Phosphoserine221 def: "Protein WAPL_HUMAN with the residue 221 substituted with Phosphoserine" [UniProtKB:Q7Z5K2] xref: UniProtKB:Q7Z5K2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:B0014651 name: WAPL_HUMAN-Phosphoserine226 def: "Protein WAPL_HUMAN with the residue 226 substituted with Phosphoserine" [UniProtKB:Q7Z5K2] xref: UniProtKB:Q7Z5K2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:B0014652 name: WAPL_HUMAN-Phosphoserine459 def: "Protein WAPL_HUMAN with the residue 459 substituted with Phosphoserine" [UniProtKB:Q7Z5K2] xref: UniProtKB:Q7Z5K2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:B0014653 name: WAPL_HUMAN-Phosphoserine461 def: "Protein WAPL_HUMAN with the residue 461 substituted with Phosphoserine" [UniProtKB:Q7Z5K2] xref: UniProtKB:Q7Z5K2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:B0014668 name: WBP2_HUMAN-Phosphotyrosine232 def: "Protein WBP2_HUMAN with the residue 232 substituted with Phosphotyrosine" [UniProtKB:Q969T9] xref: UniProtKB:Q969T9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006351 ! WBP2_HUMAN [Term] id: CCO:B0014669 name: WBP7_HUMAN-Phosphothreonine159 def: "Protein WBP7_HUMAN with the residue 159 substituted with Phosphothreonine" [UniProtKB:Q9UMN6] xref: UniProtKB:Q9UMN6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006032 ! WBP7_HUMAN [Term] id: CCO:B0014670 name: WBP7_HUMAN-Phosphoserine320 def: "Protein WBP7_HUMAN with the residue 320 substituted with Phosphoserine" [UniProtKB:Q9UMN6] comment: By similarity xref: UniProtKB:Q9UMN6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006032 ! WBP7_HUMAN [Term] id: CCO:B0014671 name: WBP7_HUMAN-Phosphoserine861 def: "Protein WBP7_HUMAN with the residue 861 substituted with Phosphoserine" [UniProtKB:Q9UMN6] xref: UniProtKB:Q9UMN6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006032 ! WBP7_HUMAN [Term] id: CCO:B0014672 name: WBP7_HUMAN-Phosphoserine1164 def: "Protein WBP7_HUMAN with the residue 1164 substituted with Phosphoserine" [UniProtKB:Q9UMN6] xref: UniProtKB:Q9UMN6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006032 ! WBP7_HUMAN [Term] id: CCO:B0014673 name: WDR26_HUMAN-Phosphoserine121 def: "Protein WDR26_HUMAN with the residue 121 substituted with Phosphoserine" [UniProtKB:Q9H7D7] xref: UniProtKB:Q9H7D7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005689 ! WDR26_HUMAN [Term] id: CCO:B0014674 name: WDR33_HUMAN-Phosphoserine7 def: "Protein WDR33_HUMAN with the residue 7 substituted with Phosphoserine" [UniProtKB:Q9C0J8] xref: UniProtKB:Q9C0J8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006169 ! WDR33_HUMAN [Term] id: CCO:B0014675 name: WDR5_HUMAN-Phosphoserine267 def: "Protein WDR5_HUMAN with the residue 267 substituted with Phosphoserine" [UniProtKB:P61964] xref: UniProtKB:P61964 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005615 ! WDR5_HUMAN [Term] id: CCO:B0014676 name: WDR61_HUMAN-N-acetylthreonine2 def: "Protein WDR61_HUMAN with the residue 2 substituted with N-acetylthreonine" [UniProtKB:Q9GZS3] comment: By similarity xref: UniProtKB:Q9GZS3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005999 ! WDR61_HUMAN [Term] id: CCO:B0014677 name: WDR62_HUMAN-Phosphoserine33 def: "Protein WDR62_HUMAN with the residue 33 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014678 name: WDR62_HUMAN-Phosphoserine987 def: "Protein WDR62_HUMAN with the residue 987 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014679 name: WDR62_HUMAN-Phosphoserine992 def: "Protein WDR62_HUMAN with the residue 992 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014680 name: WDR62_HUMAN-Phosphoserine995 def: "Protein WDR62_HUMAN with the residue 995 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014681 name: WDR62_HUMAN-Phosphothreonine1053 def: "Protein WDR62_HUMAN with the residue 1053 substituted with Phosphothreonine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014682 name: WDR62_HUMAN-Phosphoserine1070 def: "Protein WDR62_HUMAN with the residue 1070 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014683 name: WDR62_HUMAN-Phosphoserine1093 def: "Protein WDR62_HUMAN with the residue 1093 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014684 name: WDR62_HUMAN-Phosphoserine1101 def: "Protein WDR62_HUMAN with the residue 1101 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014685 name: WDR62_HUMAN-Phosphoserine1228 def: "Protein WDR62_HUMAN with the residue 1228 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014686 name: WDR62_HUMAN-Phosphoserine1348 def: "Protein WDR62_HUMAN with the residue 1348 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014687 name: WDR62_HUMAN-Phosphoserine1405 def: "Protein WDR62_HUMAN with the residue 1405 substituted with Phosphoserine" [UniProtKB:O43379] xref: UniProtKB:O43379 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:B0014688 name: WDR82_HUMAN-Phosphoserine154 def: "Protein WDR82_HUMAN with the residue 154 substituted with Phosphoserine" [UniProtKB:Q6UXN9] comment: By similarity xref: UniProtKB:Q6UXN9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005688 ! WDR82_HUMAN [Term] id: CCO:B0014689 name: WEE1_HUMAN-Phosphoserine123 def: "Protein WEE1_HUMAN with the residue 123 substituted with Phosphoserine" [UniProtKB:P30291] comment: by CDC2; Potential xref: UniProtKB:P30291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001575 ! WEE1_HUMAN [Term] id: CCO:B0014690 name: WEE1_HUMAN-Phosphoserine127 def: "Protein WEE1_HUMAN with the residue 127 substituted with Phosphoserine" [UniProtKB:P30291] xref: UniProtKB:P30291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001575 ! WEE1_HUMAN [Term] id: CCO:B0014691 name: WEE1_HUMAN-Phosphoserine139 def: "Protein WEE1_HUMAN with the residue 139 substituted with Phosphoserine" [UniProtKB:P30291] xref: UniProtKB:P30291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001081 ! non-membrane spanning protein tyrosine kinase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_function CCO:F0008374 ! protein tyrosine kinase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: transformation_of CCO:B0001575 ! WEE1_HUMAN [Term] id: CCO:B0014692 name: WEE1_HUMAN-Phosphoserine165 def: "Protein WEE1_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:P30291] xref: UniProtKB:P30291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001575 ! WEE1_HUMAN [Term] id: CCO:B0014693 name: WEE1_HUMAN-Phosphothreonine173 def: "Protein WEE1_HUMAN with the residue 173 substituted with Phosphothreonine" [UniProtKB:P30291] xref: UniProtKB:P30291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001575 ! WEE1_HUMAN [Term] id: CCO:B0014694 name: WEE1_HUMAN-Phosphoserine642 def: "Protein WEE1_HUMAN with the residue 642 substituted with Phosphoserine" [UniProtKB:P30291] comment: by BRSK1; in vitro; xref: UniProtKB:P30291 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001575 ! WEE1_HUMAN [Term] id: CCO:B0014695 name: WNK4_HUMAN-Phosphoserine331 def: "Protein WNK4_HUMAN with the residue 331 substituted with Phosphoserine" [UniProtKB:Q96J92] comment: by autocatalysis; xref: UniProtKB:Q96J92 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005934 ! WNK4_HUMAN [Term] id: CCO:B0014696 name: WNK4_HUMAN-Phosphoserine335 def: "Protein WNK4_HUMAN with the residue 335 substituted with Phosphoserine" [UniProtKB:Q96J92] comment: by autocatalysis; xref: UniProtKB:Q96J92 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005934 ! WNK4_HUMAN [Term] id: CCO:B0014697 name: WRN_HUMAN-Phosphoserine1058 def: "Protein WRN_HUMAN with the residue 1058 substituted with Phosphoserine" [UniProtKB:Q14191] xref: UniProtKB:Q14191 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:B0014698 name: WRN_HUMAN-Phosphoserine1141 def: "Protein WRN_HUMAN with the residue 1141 substituted with Phosphoserine" [UniProtKB:Q14191] xref: UniProtKB:Q14191 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:B0014699 name: WWC1_HUMAN-Phosphoserine899 def: "Protein WWC1_HUMAN with the residue 899 substituted with Phosphoserine" [UniProtKB:Q8IX03] comment: By similarity xref: UniProtKB:Q8IX03 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006200 ! WWC1_HUMAN [Term] id: CCO:B0014700 name: WWC1_HUMAN-Phosphoserine922 def: "Protein WWC1_HUMAN with the residue 922 substituted with Phosphoserine" [UniProtKB:Q8IX03] xref: UniProtKB:Q8IX03 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006200 ! WWC1_HUMAN [Term] id: CCO:B0014701 name: WWC1_HUMAN-Phosphothreonine923 def: "Protein WWC1_HUMAN with the residue 923 substituted with Phosphothreonine" [UniProtKB:Q8IX03] xref: UniProtKB:Q8IX03 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006200 ! WWC1_HUMAN [Term] id: CCO:B0014702 name: WWC1_HUMAN-Phosphoserine927 def: "Protein WWC1_HUMAN with the residue 927 substituted with Phosphoserine" [UniProtKB:Q8IX03] xref: UniProtKB:Q8IX03 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006200 ! WWC1_HUMAN [Term] id: CCO:B0014703 name: WWOX_HUMAN-Phosphoserine14 def: "Protein WWOX_HUMAN with the residue 14 substituted with Phosphoserine" [UniProtKB:Q9NZC7] comment: By similarity xref: UniProtKB:Q9NZC7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002181 ! WWOX_HUMAN [Term] id: CCO:B0014704 name: WWOX_HUMAN-Phosphotyrosine33 def: "Protein WWOX_HUMAN with the residue 33 substituted with Phosphotyrosine" [UniProtKB:Q9NZC7] xref: UniProtKB:Q9NZC7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002181 ! WWOX_HUMAN [Term] id: CCO:B0014707 name: XPA_HUMAN-Phosphoserine196 def: "Protein XPA_HUMAN with the residue 196 substituted with Phosphoserine" [UniProtKB:P23025] xref: UniProtKB:P23025 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005345 ! XPA_HUMAN [Term] id: CCO:B0014708 name: XPC_HUMAN-Phosphoserine94 def: "Protein XPC_HUMAN with the residue 94 substituted with Phosphoserine" [UniProtKB:Q01831] xref: UniProtKB:Q01831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001714 ! XPC_HUMAN [Term] id: CCO:B0014709 name: XPC_HUMAN-Phosphoserine347 def: "Protein XPC_HUMAN with the residue 347 substituted with Phosphoserine" [UniProtKB:Q01831] xref: UniProtKB:Q01831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000279 ! damaged DNA binding relationship: has_function CCO:F0000288 ! single-stranded DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: transformation_of CCO:B0001714 ! XPC_HUMAN [Term] id: CCO:B0014710 name: XPC_HUMAN-Phosphoserine351 def: "Protein XPC_HUMAN with the residue 351 substituted with Phosphoserine" [UniProtKB:Q01831] xref: UniProtKB:Q01831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001714 ! XPC_HUMAN [Term] id: CCO:B0014711 name: XPC_HUMAN-Phosphoserine883 def: "Protein XPC_HUMAN with the residue 883 substituted with Phosphoserine" [UniProtKB:Q01831] xref: UniProtKB:Q01831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001714 ! XPC_HUMAN [Term] id: CCO:B0014712 name: XPC_HUMAN-Phosphoserine884 def: "Protein XPC_HUMAN with the residue 884 substituted with Phosphoserine" [UniProtKB:Q01831] xref: UniProtKB:Q01831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001714 ! XPC_HUMAN [Term] id: CCO:B0014713 name: XPC_HUMAN-Phosphoserine892 def: "Protein XPC_HUMAN with the residue 892 substituted with Phosphoserine" [UniProtKB:Q01831] xref: UniProtKB:Q01831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001714 ! XPC_HUMAN [Term] id: CCO:B0014714 name: XPO1_HUMAN-Phosphoserine397 def: "Protein XPO1_HUMAN with the residue 397 substituted with Phosphoserine" [UniProtKB:O14980] xref: UniProtKB:O14980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005867 ! XPO1_HUMAN [Term] id: CCO:B0014715 name: XPO2_HUMAN-N-acetylmethionine1 def: "Protein XPO2_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P55060] xref: UniProtKB:P55060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005662 ! XPO2_HUMAN [Term] id: CCO:B0014716 name: XPO7_HUMAN-N-acetylalanine2 def: "Protein XPO7_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9UIA9] xref: UniProtKB:Q9UIA9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005665 ! XPO7_HUMAN [Term] id: CCO:B0014717 name: XRCC2_HUMAN-Phosphoserine247 def: "Protein XRCC2_HUMAN with the residue 247 substituted with Phosphoserine" [UniProtKB:O43543] xref: UniProtKB:O43543 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001392 ! XRCC2_HUMAN [Term] id: CCO:B0014718 name: XRCC2_HUMAN-Phosphoserine249 def: "Protein XRCC2_HUMAN with the residue 249 substituted with Phosphoserine" [UniProtKB:O43543] xref: UniProtKB:O43543 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001707 ! DNA-dependent ATPase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: transformation_of CCO:B0001392 ! XRCC2_HUMAN [Term] id: CCO:B0014719 name: XRCC4_HUMAN-Phosphoserine260 def: "Protein XRCC4_HUMAN with the residue 260 substituted with Phosphoserine" [UniProtKB:Q13426] comment: by PRKDC; xref: UniProtKB:Q13426 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005651 ! XRCC4_HUMAN [Term] id: CCO:B0014720 name: XRCC4_HUMAN-Phosphoserine320 def: "Protein XRCC4_HUMAN with the residue 320 substituted with Phosphoserine" [UniProtKB:Q13426] comment: by PRKDC; xref: UniProtKB:Q13426 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005651 ! XRCC4_HUMAN [Term] id: CCO:B0014721 name: XRN1_HUMAN-Phosphoserine1173 def: "Protein XRN1_HUMAN with the residue 1173 substituted with Phosphoserine" [UniProtKB:Q8IZH2] xref: UniProtKB:Q8IZH2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001954 ! XRN1_HUMAN [Term] id: CCO:B0014722 name: XRN1_HUMAN-Phosphoserine1176 def: "Protein XRN1_HUMAN with the residue 1176 substituted with Phosphoserine" [UniProtKB:Q8IZH2] xref: UniProtKB:Q8IZH2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001954 ! XRN1_HUMAN [Term] id: CCO:B0014723 name: YBOX1_HUMAN-Phosphoserine102 def: "Protein YBOX1_HUMAN with the residue 102 substituted with Phosphoserine" [UniProtKB:P67809] comment: by PKB/AKT1; xref: UniProtKB:P67809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005742 ! YBOX1_HUMAN [Term] id: CCO:B0014724 name: YBOX1_HUMAN-Phosphotyrosine162 def: "Protein YBOX1_HUMAN with the residue 162 substituted with Phosphotyrosine" [UniProtKB:P67809] xref: UniProtKB:P67809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005742 ! YBOX1_HUMAN [Term] id: CCO:B0014725 name: YBOX1_HUMAN-Phosphoserine165 def: "Protein YBOX1_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:P67809] xref: UniProtKB:P67809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005742 ! YBOX1_HUMAN [Term] id: CCO:B0014726 name: YBOX1_HUMAN-Phosphoserine174 def: "Protein YBOX1_HUMAN with the residue 174 substituted with Phosphoserine" [UniProtKB:P67809] xref: UniProtKB:P67809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005742 ! YBOX1_HUMAN [Term] id: CCO:B0014727 name: YBOX1_HUMAN-Phosphoserine176 def: "Protein YBOX1_HUMAN with the residue 176 substituted with Phosphoserine" [UniProtKB:P67809] xref: UniProtKB:P67809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005742 ! YBOX1_HUMAN [Term] id: CCO:B0014728 name: YBOX1_HUMAN-Phosphoserine314 def: "Protein YBOX1_HUMAN with the residue 314 substituted with Phosphoserine" [UniProtKB:P67809] xref: UniProtKB:P67809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005742 ! YBOX1_HUMAN [Term] id: CCO:B0014729 name: YES_HUMAN-Phosphotyrosine426 def: "Protein YES_HUMAN with the residue 426 substituted with Phosphotyrosine" [UniProtKB:P07947] comment: by autocatalysis; xref: UniProtKB:P07947 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005465 ! YES_HUMAN [Term] id: CCO:B0014730 name: YES_HUMAN-Phosphotyrosine537 def: "Protein YES_HUMAN with the residue 537 substituted with Phosphotyrosine" [UniProtKB:P07947] xref: UniProtKB:P07947 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005465 ! YES_HUMAN [Term] id: CCO:B0014731 name: ZC11A_HUMAN-Phosphoserine108 def: "Protein ZC11A_HUMAN with the residue 108 substituted with Phosphoserine" [UniProtKB:O75152] xref: UniProtKB:O75152 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:B0014732 name: ZC11A_HUMAN-Phosphoserine116 def: "Protein ZC11A_HUMAN with the residue 116 substituted with Phosphoserine" [UniProtKB:O75152] xref: UniProtKB:O75152 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:B0014733 name: ZC11A_HUMAN-Phosphoserine132 def: "Protein ZC11A_HUMAN with the residue 132 substituted with Phosphoserine" [UniProtKB:O75152] xref: UniProtKB:O75152 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:B0014734 name: ZC11A_HUMAN-Phosphoserine290 def: "Protein ZC11A_HUMAN with the residue 290 substituted with Phosphoserine" [UniProtKB:O75152] xref: UniProtKB:O75152 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:B0014735 name: ZC11A_HUMAN-Phosphoserine495 def: "Protein ZC11A_HUMAN with the residue 495 substituted with Phosphoserine" [UniProtKB:O75152] xref: UniProtKB:O75152 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:B0014736 name: ZC11A_HUMAN-Phosphoserine758 def: "Protein ZC11A_HUMAN with the residue 758 substituted with Phosphoserine" [UniProtKB:O75152] xref: UniProtKB:O75152 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:B0014737 name: ZC11A_HUMAN-Phosphoserine759 def: "Protein ZC11A_HUMAN with the residue 759 substituted with Phosphoserine" [UniProtKB:O75152] xref: UniProtKB:O75152 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:B0014738 name: ZC11A_HUMAN-Phosphoserine761 def: "Protein ZC11A_HUMAN with the residue 761 substituted with Phosphoserine" [UniProtKB:O75152] xref: UniProtKB:O75152 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:B0014739 name: ZC11A_HUMAN-Phosphothreonine762 def: "Protein ZC11A_HUMAN with the residue 762 substituted with Phosphothreonine" [UniProtKB:O75152] xref: UniProtKB:O75152 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:B0014740 name: ZHX1_HUMAN-Phosphothreonine36 def: "Protein ZHX1_HUMAN with the residue 36 substituted with Phosphothreonine" [UniProtKB:Q9UKY1] xref: UniProtKB:Q9UKY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005395 ! ZHX1_HUMAN [Term] id: CCO:B0014741 name: ZHX1_HUMAN-Phosphoserine45 def: "Protein ZHX1_HUMAN with the residue 45 substituted with Phosphoserine" [UniProtKB:Q9UKY1] comment: By similarity xref: UniProtKB:Q9UKY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005395 ! ZHX1_HUMAN [Term] id: CCO:B0014742 name: ZHX1_HUMAN-Phosphoserine47 def: "Protein ZHX1_HUMAN with the residue 47 substituted with Phosphoserine" [UniProtKB:Q9UKY1] comment: By similarity xref: UniProtKB:Q9UKY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005395 ! ZHX1_HUMAN [Term] id: CCO:B0014743 name: ZHX1_HUMAN-Phosphoserine48 def: "Protein ZHX1_HUMAN with the residue 48 substituted with Phosphoserine" [UniProtKB:Q9UKY1] comment: By similarity xref: UniProtKB:Q9UKY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005395 ! ZHX1_HUMAN [Term] id: CCO:B0014744 name: ZHX1_HUMAN-Phosphoserine648 def: "Protein ZHX1_HUMAN with the residue 648 substituted with Phosphoserine" [UniProtKB:Q9UKY1] xref: UniProtKB:Q9UKY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005395 ! ZHX1_HUMAN [Term] id: CCO:B0014745 name: ZHX1_HUMAN-Phosphothreonine682 def: "Protein ZHX1_HUMAN with the residue 682 substituted with Phosphothreonine" [UniProtKB:Q9UKY1] xref: UniProtKB:Q9UKY1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005395 ! ZHX1_HUMAN [Term] id: CCO:B0014746 name: ZNF24_HUMAN-Phosphoserine261 def: "Protein ZNF24_HUMAN with the residue 261 substituted with Phosphoserine" [UniProtKB:P17028] xref: UniProtKB:P17028 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006085 ! ZNF24_HUMAN [Term] id: CCO:B0014747 name: ZNF24_HUMAN-Phosphotyrosine279 def: "Protein ZNF24_HUMAN with the residue 279 substituted with Phosphotyrosine" [UniProtKB:P17028] xref: UniProtKB:P17028 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006085 ! ZNF24_HUMAN [Term] id: CCO:B0014748 name: ZNF24_HUMAN-Phosphotyrosine335 def: "Protein ZNF24_HUMAN with the residue 335 substituted with Phosphotyrosine" [UniProtKB:P17028] xref: UniProtKB:P17028 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006085 ! ZNF24_HUMAN [Term] id: CCO:B0014749 name: ZNHI1_HUMAN-Phosphothreonine103 def: "Protein ZNHI1_HUMAN with the residue 103 substituted with Phosphothreonine" [UniProtKB:O43257] comment: by MAPK11 and MAPK14; xref: UniProtKB:O43257 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005362 ! ZNHI1_HUMAN [Term] id: CCO:B0014764 name: ZW10_HUMAN-Phosphothreonine438 def: "Protein ZW10_HUMAN with the residue 438 substituted with Phosphothreonine" [UniProtKB:O43264] xref: UniProtKB:O43264 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0004138 ! centromeric DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: located_in CCO:C0000103 ! kinetochore relationship: located_in CCO:C0000144 ! spindle pole relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000364 ! endoplasmic reticulum relationship: located_in CCO:C0000370 ! endoplasmic reticulum membrane relationship: located_in CCO:C0000388 ! spindle relationship: located_in CCO:C0000396 ! kinetochore microtubule relationship: located_in CCO:C0000766 ! membrane relationship: transformation_of CCO:B0001387 ! ZW10_HUMAN [Term] id: CCO:B0014765 name: ZWIA_HUMAN-Phosphothreonine51 def: "Protein ZWIA_HUMAN with the residue 51 substituted with Phosphothreonine" [UniProtKB:Q99546] comment: Potential xref: UniProtKB:Q99546 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002070 ! ZWIA_HUMAN [Term] id: CCO:B0014766 name: ZWIA_HUMAN-Phosphoserine65 def: "Protein ZWIA_HUMAN with the residue 65 substituted with Phosphoserine" [UniProtKB:Q99546] comment: Potential xref: UniProtKB:Q99546 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000272 ! molecular_function relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0002070 ! ZWIA_HUMAN [Term] id: CCO:B0014767 name: ZWIA_HUMAN-Phosphoserine78 def: "Protein ZWIA_HUMAN with the residue 78 substituted with Phosphoserine" [UniProtKB:Q99546] comment: Potential xref: UniProtKB:Q99546 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002070 ! ZWIA_HUMAN [Term] id: CCO:B0014768 name: ZWIA_HUMAN-Phosphoserine92 def: "Protein ZWIA_HUMAN with the residue 92 substituted with Phosphoserine" [UniProtKB:Q99546] comment: Potential xref: UniProtKB:Q99546 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002070 ! ZWIA_HUMAN [Term] id: CCO:B0014769 name: ZYX_HUMAN-Phosphoserine142 def: "Protein ZYX_HUMAN with the residue 142 substituted with Phosphoserine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014770 name: ZYX_HUMAN-Phosphoserine143 def: "Protein ZYX_HUMAN with the residue 143 substituted with Phosphoserine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014771 name: ZYX_HUMAN-Phosphothreonine159 def: "Protein ZYX_HUMAN with the residue 159 substituted with Phosphothreonine" [UniProtKB:Q15942] comment: By similarity xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014772 name: ZYX_HUMAN-Phosphothreonine179 def: "Protein ZYX_HUMAN with the residue 179 substituted with Phosphothreonine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014773 name: ZYX_HUMAN-Phosphoserine259 def: "Protein ZYX_HUMAN with the residue 259 substituted with Phosphoserine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014774 name: ZYX_HUMAN-Phosphoserine267 def: "Protein ZYX_HUMAN with the residue 267 substituted with Phosphoserine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014775 name: ZYX_HUMAN-Phosphoserine281 def: "Protein ZYX_HUMAN with the residue 281 substituted with Phosphoserine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014776 name: ZYX_HUMAN-Phosphoserine290 def: "Protein ZYX_HUMAN with the residue 290 substituted with Phosphoserine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014777 name: ZYX_HUMAN-Phosphoserine308 def: "Protein ZYX_HUMAN with the residue 308 substituted with Phosphoserine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014778 name: ZYX_HUMAN-Phosphoserine344 def: "Protein ZYX_HUMAN with the residue 344 substituted with Phosphoserine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0014779 name: ZZEF1_HUMAN-Phosphoserine1464 def: "Protein ZZEF1_HUMAN with the residue 1464 substituted with Phosphoserine" [UniProtKB:O43149] comment: By similarity xref: UniProtKB:O43149 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001380 ! ZZEF1_HUMAN [Term] id: CCO:B0014780 name: ZZEF1_HUMAN-Phosphoserine2444 def: "Protein ZZEF1_HUMAN with the residue 2444 substituted with Phosphoserine" [UniProtKB:O43149] comment: By similarity xref: UniProtKB:O43149 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001380 ! ZZEF1_HUMAN [Term] id: CCO:B0017902 name: RBM38_HUMAN def: "RNA-binding protein 38" [UniProtKB:Q9H0Z9] synonym: "CLL-associated antigen KW-5" EXACT [UniProtKB:Q9H0Z9] synonym: "HSRNASEB" EXACT [UniProtKB:Q9H0Z9] synonym: "RNA-binding motif protein 38" EXACT [UniProtKB:Q9H0Z9] synonym: "RNA-binding region-containing protein 1" EXACT [UniProtKB:Q9H0Z9] synonym: "ssDNA-binding protein SEB4" EXACT [UniProtKB:Q9H0Z9] xref: EMBL:AAH18711.1 xref: EMBL:AAL99924.1 xref: EMBL:CAA53063.1 xref: EMBL:CAA53064.1 xref: UniProtKB:Q15350 xref: UniProtKB:Q15351 xref: UniProtKB:Q9BYK3 xref: UniProtKB:Q9BYK4 xref: UniProtKB:Q9H0Z9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0010896 ! RBM38_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000065 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [Term] id: CCO:B0019067 name: RORA_HUMAN def: "Nuclear receptor ROR-alpha" [UniProtKB:P35398] synonym: "Nuclear receptor RZR-alpha" EXACT [UniProtKB:P35398] synonym: "Nuclear receptor subfamily 1 group F member 1" EXACT [UniProtKB:P35398] synonym: "Retinoid-related orphan receptor-alpha" EXACT [UniProtKB:P35398] xref: EMBL:AAA02963.1 xref: EMBL:AAA62658.1 xref: EMBL:AAA62659.1 xref: EMBL:AAA62660.1 xref: EMBL:AAH08831.1 xref: UniProtKB:P35397 xref: UniProtKB:P35398 xref: UniProtKB:P35399 xref: UniProtKB:P45445 xref: UniProtKB:Q96H83 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0008119 ! RORA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008685 ! psmc5-rora physical interaction relationship: participates_in CCO:I0008763 ! psmc5-rora-1 physical interaction [Term] id: CCO:B0019193 name: MYH9_HUMAN def: "Myosin-9" [UniProtKB:P35579] synonym: "Cellular myosin heavy chain, type A" EXACT [UniProtKB:P35579] synonym: "Myosin heavy chain 9" EXACT [UniProtKB:P35579] synonym: "Myosin heavy chain, non-muscle IIa" EXACT [UniProtKB:P35579] synonym: "NMMHC II-a" EXACT [UniProtKB:P35579] synonym: "NMMHC-A" EXACT [UniProtKB:P35579] synonym: "NMMHC-IIA" EXACT [UniProtKB:P35579] synonym: "Non-muscle myosin heavy chain IIa" EXACT [UniProtKB:P35579] synonym: "Non-muscle myosin heavy chain-A" EXACT [UniProtKB:P35579] xref: EMBL:AAA36349.1 xref: EMBL:AAA59888.1 xref: EMBL:AAA61765.1 xref: EMBL:CAB05105.1 xref: EMBL:CAG30412.1 xref: UniProtKB:O60805 xref: UniProtKB:P35579 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0007855 ! MYH9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008564 ! menin-myh9-1 physical interaction relationship: participates_in CCO:I0008567 ! menin-myh9-6 physical interaction relationship: participates_in CCO:I0008576 ! menin-myh9-4 direct interaction relationship: participates_in CCO:I0008577 ! myh9-menin-1 direct interaction relationship: participates_in CCO:I0008579 ! menin-myh9-3 physical interaction relationship: participates_in CCO:I0008581 ! menin-myh9-2 physical interaction relationship: participates_in CCO:I0008582 ! menin-myh9-5 colocalization relationship: transforms_into CCO:B0035233 ! MYH9_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0035234 ! MYH9_HUMAN-Phosphothreonine181 relationship: transforms_into CCO:B0035235 ! MYH9_HUMAN-Phosphothreonine638 relationship: transforms_into CCO:B0035236 ! MYH9_HUMAN-Phosphotyrosine754 relationship: transforms_into CCO:B0035237 ! MYH9_HUMAN-Phosphoserine1943 relationship: transforms_into CCO:B0041162 ! MYH9_HUMAN-Phosphoserine1714 [Term] id: CCO:B0019194 name: MYH10_HUMAN def: "Myosin-10" [UniProtKB:P35580] synonym: "Cellular myosin heavy chain, type B" EXACT [UniProtKB:P35580] synonym: "Myosin heavy chain 10" EXACT [UniProtKB:P35580] synonym: "Myosin heavy chain, non-muscle IIb" EXACT [UniProtKB:P35580] synonym: "NMMHC II-b" EXACT [UniProtKB:P35580] synonym: "NMMHC-B" EXACT [UniProtKB:P35580] synonym: "NMMHC-IIB" EXACT [UniProtKB:P35580] synonym: "Non-muscle myosin heavy chain IIb" EXACT [UniProtKB:P35580] synonym: "Non-muscle myosin heavy chain-B" EXACT [UniProtKB:P35580] xref: EMBL:AAA87712.1 xref: EMBL:AAA99177.1 xref: EMBL:AAB28952.1 xref: UniProtKB:P35580 xref: UniProtKB:Q12989 xref: UniProtKB:Q16087 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006426 ! MYH10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction relationship: participates_in CCO:I0008542 ! chuk-myh10 physical interaction relationship: participates_in CCO:I0008543 ! ikbkb-myh10 physical interaction relationship: participates_in CCO:I0008544 ! ikbke-myh10 physical interaction relationship: participates_in CCO:I0008545 ! ikbkg-myh10 physical interaction relationship: participates_in CCO:I0008546 ! map3k1-myh10 physical interaction relationship: participates_in CCO:I0008547 ! map3k3-myh10 physical interaction relationship: participates_in CCO:I0008548 ! ripk2-myh10 physical interaction relationship: participates_in CCO:I0008549 ! aah62584-myh10 physical interaction relationship: participates_in CCO:I0008550 ! tnfrsf1a-myh10 physical interaction relationship: participates_in CCO:I0008551 ! tnfrsf1b-myh10 physical interaction relationship: participates_in CCO:P0000040 ! cytokinesis after mitosis relationship: transforms_into CCO:B0032851 ! MYH10_HUMAN-Phosphoserine1013 relationship: transforms_into CCO:B0032852 ! MYH10_HUMAN-Phosphoserine1938 relationship: transforms_into CCO:B0032853 ! MYH10_HUMAN-Phosphoserine1952 relationship: transforms_into CCO:B0032854 ! MYH10_HUMAN-Phosphoserine1956 relationship: transforms_into CCO:B0032855 ! MYH10_HUMAN-Phosphothreonine1960 relationship: transforms_into CCO:B0036017 ! MYH10_HUMAN-Phosphothreonine1376 [Term] id: CCO:B0019420 name: Q53FN2_HUMAN def: "Cell division cycle protein 23 variant" [UniProtKB:Q53FN2] xref: EMBL:BAD96970.1 xref: UniProtKB:Q53FN2 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0001633 ! binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000282 ! anaphase-promoting complex relationship: participates_in CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition [Term] id: CCO:B0019462 name: UB2D1_HUMAN def: "Ubiquitin-conjugating enzyme E2 D1" [UniProtKB:P51668] synonym: "E2(17)KB 1" EXACT [UniProtKB:P51668] synonym: "EC 6.3.2.19" EXACT [UniProtKB:P51668] synonym: "SFT" EXACT [UniProtKB:P51668] synonym: "Stimulator of Fe transport" EXACT [UniProtKB:P51668] synonym: "UBC4/5 homolog" EXACT [UniProtKB:P51668] synonym: "UbcH5" EXACT [UniProtKB:P51668] synonym: "Ubiquitin carrier protein D1" EXACT [UniProtKB:P51668] synonym: "Ubiquitin-conjugating enzyme E2-17 kDa 1" EXACT [UniProtKB:P51668] synonym: "Ubiquitin-protein ligase D1" EXACT [UniProtKB:P51668] xref: EMBL:AAH05980.1 xref: EMBL:AAH15997.1 xref: EMBL:AAM81086.1 xref: EMBL:AAP35690.1 xref: EMBL:CAA55019.1 xref: EMBL:CAC82097.1 xref: EMBL:CAC82177.1 xref: UniProtKB:P51668 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008330 ! UBE2D1_human relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0003433 ! ligase activity relationship: has_function CCO:F0004170 ! small conjugating protein ligase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:I0008676 ! trim39-ube2d1 physical interaction relationship: participates_in CCO:I0008682 ! rnf126-ube2d1 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0021356 name: Q8IY91_HUMAN def: "Cyclin A1" [UniProtKB:Q8IY91] synonym: "Cyclin A1, isoform CRA_b" EXACT [UniProtKB:Q8IY91] xref: EMBL:AAH36346.1 xref: EMBL:EAX08566.1 xref: UniProtKB:Q8IY91 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004242 ! CCNA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0021560 name: PSMD3_HUMAN def: "26S proteasome non-ATPase regulatory subunit 3" [UniProtKB:O43242] synonym: "26S proteasome regulatory subunit S3" EXACT [UniProtKB:O43242] synonym: "Proteasome subunit p58" EXACT [UniProtKB:O43242] xref: EMBL:AAH00074.1 xref: EMBL:AAH04859.1 xref: EMBL:AAH12302.1 xref: EMBL:AAH20518.1 xref: EMBL:AAH25686.1 xref: EMBL:AAP35881.1 xref: EMBL:BAA23651.1 xref: UniProtKB:O43242 xref: UniProtKB:Q96EI2 xref: UniProtKB:Q9BQA4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008033 ! PSMD3_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: participates_in CCO:I0008718 ! traf6-psmd3 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0022204 name: PSA5_HUMAN def: "Proteasome subunit alpha type-5" [UniProtKB:P28066] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P28066] synonym: "Macropain zeta chain" EXACT [UniProtKB:P28066] synonym: "Multicatalytic endopeptidase complex zeta chain" EXACT [UniProtKB:P28066] synonym: "Proteasome zeta chain" EXACT [UniProtKB:P28066] xref: EMBL:AAI02019.1 xref: EMBL:AAI02020.1 xref: EMBL:AAI02021.1 xref: EMBL:AAI03752.1 xref: EMBL:CAA43962.1 xref: EMBL:CAG33128.1 xref: EMBL:CAH70887.1 xref: EMBL:CAI13171.1 xref: UniProtKB:P28066 xref: UniProtKB:Q3T1C1 xref: UniProtKB:Q6IBF7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008017 ! PSMA5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008703 ! nfkbie-psma5 physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0035474 ! PSA5_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0035475 ! PSA5_HUMAN-Phosphoserine16 relationship: transforms_into CCO:B0035476 ! PSA5_HUMAN-Phosphoserine56 [Term] id: CCO:B0022308 name: Q1MSW9_HUMAN def: "Cellular tumor antigen p53" [UniProtKB:Q1MSW9] xref: EMBL:ABL09848.1 xref: EMBL:CAJ28924.1 xref: UniProtKB:Q1MSW9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005245 ! TP53_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0023340 name: Q59H84_HUMAN def: "Septin 10 isoform 2 variant" [UniProtKB:Q59H84] xref: EMBL:BAD92112.1 xref: UniProtKB:Q59H84 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0023347 name: Q9H9P7_HUMAN def: "cDNA FLJ12620 fis, clone NT2RM4001714, moderately similar to SEPTIN 2 HOMOLOG" [UniProtKB:Q9H9P7] xref: EMBL:BAB14176.1 xref: UniProtKB:Q9H9P7 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0023348 name: Q8NFH9_HUMAN def: "MLL/SEPTIN6 fusion protein" [UniProtKB:Q8NFH9] xref: EMBL:AAM82548.1 xref: UniProtKB:Q8NFH9 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0023351 name: Q6B514_HUMAN def: "Septin 6 isoform E" [UniProtKB:Q6B514] xref: EMBL:AAT80339.1 xref: UniProtKB:Q6B514 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0023606 name: PSDE_HUMAN def: "26S proteasome non-ATPase regulatory subunit 14" [UniProtKB:O00487] synonym: "26S proteasome regulatory subunit rpn11" EXACT [UniProtKB:O00487] synonym: "26S proteasome-associated PAD1 homolog 1" EXACT [UniProtKB:O00487] xref: EMBL:AAC51866.1 xref: EMBL:AAH66336.1 xref: UniProtKB:O00176 xref: UniProtKB:O00487 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008028 ! PSMD14_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: participates_in CCO:I0008807 ! psmd14-plekhb2 physical interaction relationship: participates_in CCO:I0008822 ! psmd14-flj10324 physical interaction relationship: participates_in CCO:I0008823 ! psmd14-rbm15b physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0035484 ! PSDE_HUMAN-Phosphotyrosine32 relationship: transforms_into CCO:B0035485 ! PSDE_HUMAN-Phosphoserine224 relationship: transforms_into CCO:B0041329 ! PSDE_HUMAN-Phosphoserine150 [Term] id: CCO:B0023650 name: Q53QU3_HUMAN def: "Septin" [UniProtKB:Q53QU3] xref: EMBL:AAY14718.1 xref: UniProtKB:Q53QU3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006375 ! NEDD5_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0024005 name: UBP22_HUMAN def: "Ubiquitin carboxyl-terminal hydrolase 22" [UniProtKB:Q9UPT9] synonym: "Deubiquitinating enzyme 22" EXACT [UniProtKB:Q9UPT9] synonym: "EC 3.1.2.15" EXACT [UniProtKB:Q9UPT9] synonym: "Ubiquitin thioesterase 22" EXACT [UniProtKB:Q9UPT9] synonym: "Ubiquitin-specific-processing protease 22" EXACT [UniProtKB:Q9UPT9] xref: EMBL:BAA83015.1 xref: UniProtKB:Q9UPT9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013411 ! USP22_human relationship: has_function CCO:F0000675 ! ubiquitin thiolesterase activity relationship: has_function CCO:F0001199 ! ubiquitin-specific protease activity relationship: has_function CCO:F0001783 ! peptidase activity relationship: has_function CCO:F0001784 ! cysteine-type peptidase activity relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0002509 ! H4 histone acetyltransferase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000012 ! SAGA complex relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0008814 ! usp22-hexa physical interaction relationship: participates_in CCO:I0008815 ! usp22-mrpl10 physical interaction relationship: participates_in CCO:I0008816 ! usp22-psme1 physical interaction relationship: participates_in CCO:I0008817 ! usp22-scfd1 physical interaction relationship: participates_in CCO:P0000259 ! positive regulation of mitotic cell cycle [Term] id: CCO:B0026248 name: ERCC2_HUMAN def: "TFIIH basal transcription factor complex helicase subunit" [UniProtKB:P18074] synonym: "CXPD" EXACT [UniProtKB:P18074] synonym: "DNA excision repair protein ERCC-2" EXACT [UniProtKB:P18074] synonym: "DNA-repair protein complementing XP-D cells" EXACT [UniProtKB:P18074] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P18074] synonym: "Xeroderma pigmentosum group D-complementing protein" EXACT [UniProtKB:P18074] xref: EMBL:AAI08256.1 xref: EMBL:AAL48323.1 xref: EMBL:AAM45142.1 xref: EMBL:CAA36463.1 xref: EMBL:CAA36464.1 xref: UniProtKB:P18074 xref: UniProtKB:Q2YDY2 xref: UniProtKB:Q8N721 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006358 ! ERCC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000006 ! cell cycle checkpoint [Term] id: CCO:B0026249 name: ZMY11_HUMAN def: "Zinc finger MYND domain-containing protein 11" [UniProtKB:Q15326] synonym: "Adenovirus 5 E1A-binding protein" EXACT [UniProtKB:Q15326] synonym: "Protein BS69" EXACT [UniProtKB:Q15326] xref: EMBL:CAA60052.1 xref: EMBL:CAH69845.1 xref: EMBL:CAI40899.1 xref: UniProtKB:Q15326 xref: UniProtKB:Q5VUI1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006374 ! ZMYND11_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0026393 ! ZMY11_HUMAN-Phosphoserine381 [Term] id: CCO:B0026250 name: Q5JXL7_HUMAN def: "Putative uncharacterized protein DKFZp586I031" [UniProtKB:Q5JXL7] xref: EMBL:CAI46224.1 xref: UniProtKB:Q5JXL7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006376 ! DKFZp586I031_human relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0026252 name: NOXIN_HUMAN def: "Nitric oxide-inducible gene protein" [UniProtKB:Q8IXT1] xref: EMBL:AAH39268.1 xref: EMBL:BAB14764.1 xref: EMBL:BAB71685.1 xref: UniProtKB:Q8IXT1 xref: UniProtKB:Q96LK6 xref: UniProtKB:Q9H856 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006364 ! NOXIN_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0026253 name: SEP12_HUMAN def: "Septin-12" [UniProtKB:Q8IYM1] xref: EMBL:AAH24017.1 xref: EMBL:AAH35619.1 xref: EMBL:ABE68946.1 xref: EMBL:ABF61438.1 xref: EMBL:ABR10901.1 xref: EMBL:BAB71681.1 xref: EMBL:EAW85265.1 xref: UniProtKB:Q0P6B0 xref: UniProtKB:Q1PBH0 xref: UniProtKB:Q8IYM1 xref: UniProtKB:Q96LL0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006020 ! SEPT12_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0026254 name: JUB_HUMAN def: "Protein ajuba" [UniProtKB:Q96IF1] xref: EMBL:AAH07580.1 xref: EMBL:AAH34968.1 xref: EMBL:AAO37641.1 xref: EMBL:EAW66204.1 xref: UniProtKB:Q96IF1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006039 ! JUB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007689 ! gfi1b-jub physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0026380 ! JUB_HUMAN-Phosphoserine119 relationship: transforms_into CCO:B0026381 ! JUB_HUMAN-Phosphoserine263 [Term] id: CCO:B0026255 name: KLDC3_HUMAN def: "Kelch domain-containing protein 3" [UniProtKB:Q9BQ90] synonym: "Protein Peas" EXACT [UniProtKB:Q9BQ90] synonym: "Testis intracellular mediator protein" EXACT [UniProtKB:Q9BQ90] xref: EMBL:AAH00295.1 xref: EMBL:AAH01789.1 xref: EMBL:AAH01793.1 xref: EMBL:AAH07296.1 xref: EMBL:AAH21546.1 xref: EMBL:BAB63257.1 xref: EMBL:CAI19796.1 xref: UniProtKB:Q9BQ90 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006363 ! KLHDC3_human relationship: has_function CCO:F0000278 ! chromatin binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000117 ! nuclear chromatin relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000117 ! meiosis relationship: participates_in CCO:P0000122 ! meiotic recombination [Term] id: CCO:B0026256 name: RPRM_HUMAN def: "Protein reprimo" [UniProtKB:Q9NS64] xref: EMBL:AAH02908.1 xref: EMBL:AAY14783.1 xref: EMBL:BAB01513.1 xref: EMBL:EAX11467.1 xref: UniProtKB:Q9NS64 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006052 ! RPRM_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0026257 name: PDS5B_HUMAN def: "Sister chromatid cohesion protein PDS5 homolog B" [UniProtKB:Q9NTI5] synonym: "Androgen-induced proliferation inhibitor" EXACT [UniProtKB:Q9NTI5] synonym: "Androgen-induced prostate proliferative shutoff-associated protein AS3" EXACT [UniProtKB:Q9NTI5] xref: EMBL:AAD22134.2 xref: EMBL:AAH39256.1 xref: EMBL:AAH70274.1 xref: EMBL:BAA76823.2 xref: EMBL:BAB15584.1 xref: EMBL:CAB69911.1 xref: EMBL:CAH73160.2 xref: EMBL:CAI10806.2 xref: UniProtKB:Q5R3S3 xref: UniProtKB:Q5W0K8 xref: UniProtKB:Q6NSC3 xref: UniProtKB:Q8IXT6 xref: UniProtKB:Q9H5N8 xref: UniProtKB:Q9NTI5 xref: UniProtKB:Q9Y2I5 xref: UniProtKB:Q9Y451 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006365 ! PDS5B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000078 ! mitotic sister chromatid cohesion relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0026385 ! PDS5B_HUMAN-Phosphoserine1166 relationship: transforms_into CCO:B0026386 ! PDS5B_HUMAN-Phosphoserine1257 relationship: transforms_into CCO:B0026387 ! PDS5B_HUMAN-Phosphoserine1259 relationship: transforms_into CCO:B0026388 ! PDS5B_HUMAN-Phosphoserine1358 relationship: transforms_into CCO:B0026389 ! PDS5B_HUMAN-Phosphothreonine1367 relationship: transforms_into CCO:B0026390 ! PDS5B_HUMAN-Phosphothreonine1370 relationship: transforms_into CCO:B0026391 ! PDS5B_HUMAN-Phosphoserine1383 relationship: transforms_into CCO:B0036021 ! PDS5B_HUMAN-Phosphoserine1379 [Term] id: CCO:B0026267 name: DHB14_HUMAN def: "17-beta-hydroxysteroid dehydrogenase 14" [UniProtKB:Q9BPX1] synonym: "17-beta-hydroxysteroid dehydrogenase DHRS10" EXACT [UniProtKB:Q9BPX1] synonym: "Dehydrogenase/reductase SDR family member 10" EXACT [UniProtKB:Q9BPX1] synonym: "EC 1.1.1.-" EXACT [UniProtKB:Q9BPX1] synonym: "Retinal short-chain dehydrogenase/reductase retSDR3" EXACT [UniProtKB:Q9BPX1] xref: EMBL:AAF06940.1 xref: EMBL:AAH06283.1 xref: EMBL:AAH06294.1 xref: EMBL:AAQ88796.1 xref: UniProtKB:Q9BPX1 xref: UniProtKB:Q9UKU3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006348 ! HSD17B14_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005744 ! ddit3-dhrs10 physical interaction [Term] id: CCO:B0026268 name: CACO2_HUMAN def: "Calcium-binding and coiled-coil domain-containing protein 2" [UniProtKB:Q13137] synonym: "Antigen nuclear dot 52 kDa protein" EXACT [UniProtKB:Q13137] synonym: "Nuclear domain 10 protein 52" EXACT [UniProtKB:Q13137] synonym: "Nuclear domain 10 protein NDP52" EXACT [UniProtKB:Q13137] synonym: "Nuclear dot protein 52" EXACT [UniProtKB:Q13137] xref: EMBL:AAA75297.1 xref: EMBL:AAH04130.1 xref: EMBL:AAH15893.1 xref: EMBL:BAD96386.1 xref: EMBL:BAD96947.1 xref: EMBL:CAG33044.1 xref: EMBL:EAW94707.1 xref: UniProtKB:Q13137 xref: UniProtKB:Q53FQ5 xref: UniProtKB:Q53HB5 xref: UniProtKB:Q6IBN9 xref: UniProtKB:Q9BTF7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006346 ! CALCOCO2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005792 ! ndp52-shc1 physical interaction relationship: participates_in CCO:I0008678 ! ndp52-psma1 physical interaction [Term] id: CCO:B0026269 name: EIF3G_HUMAN def: "Eukaryotic translation initiation factor 3 subunit G" [UniProtKB:O75821] synonym: "eIF-3 RNA-binding subunit" EXACT [UniProtKB:O75821] synonym: "eIF-3-delta" EXACT [UniProtKB:O75821] synonym: "eIF3 p42" EXACT [UniProtKB:O75821] synonym: "eIF3 p44" EXACT [UniProtKB:O75821] synonym: "eIF3g" EXACT [UniProtKB:O75821] synonym: "Eukaryotic translation initiation factor 3 subunit 4" EXACT [UniProtKB:O75821] xref: EMBL:AAB71866.1 xref: EMBL:AAC78728.1 xref: EMBL:AAG15396.1 xref: EMBL:AAG15419.1 xref: EMBL:AAH00733.1 xref: EMBL:AAH08469.1 xref: EMBL:AAP35535.1 xref: UniProtKB:O14801 xref: UniProtKB:O75821 xref: UniProtKB:Q969U5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006354 ! EIF3G_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006485 ! mphosph6-eif3s4 physical interaction relationship: transforms_into CCO:B0026371 ! EIF3G_HUMAN-Phosphothreonine41 relationship: transforms_into CCO:B0026372 ! EIF3G_HUMAN-Phosphoserine42 [Term] id: CCO:B0026270 name: EIF3D_HUMAN def: "Eukaryotic translation initiation factor 3 subunit D" [UniProtKB:O15371] synonym: "eIF-3-zeta" EXACT [UniProtKB:O15371] synonym: "eIF3 p66" EXACT [UniProtKB:O15371] synonym: "eIF3d" EXACT [UniProtKB:O15371] synonym: "Eukaryotic translation initiation factor 3 subunit 7" EXACT [UniProtKB:O15371] xref: EMBL:AAD03466.1 xref: EMBL:AAH00328.1 xref: EMBL:AAH00469.1 xref: EMBL:AAH14912.1 xref: EMBL:AAH80515.1 xref: EMBL:AAH93100.1 xref: EMBL:AAH93686.1 xref: EMBL:AAI01478.1 xref: EMBL:AAP36045.1 xref: EMBL:CAA18440.1 xref: EMBL:CAG30375.1 xref: UniProtKB:O15371 xref: UniProtKB:Q3MJD9 xref: UniProtKB:Q5M9Q6 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006351 ! EIF3D_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0026365 ! EIF3D_HUMAN-Phosphoserine67 relationship: transforms_into CCO:B0026366 ! EIF3D_HUMAN-Phosphotyrosine318 relationship: transforms_into CCO:B0026367 ! EIF3D_HUMAN-Phosphoserine528 relationship: transforms_into CCO:B0026368 ! EIF3D_HUMAN-Phosphoserine529 [Term] id: CCO:B0026271 name: EIF3C_HUMAN def: "Eukaryotic translation initiation factor 3 subunit C" [UniProtKB:Q99613] synonym: "eIF3 p110" EXACT [UniProtKB:Q99613] synonym: "eIF3c" EXACT [UniProtKB:Q99613] synonym: "Eukaryotic translation initiation factor 3 subunit 8" EXACT [UniProtKB:Q99613] xref: EMBL:AAC27426.1 xref: EMBL:AAC27674.1 xref: EMBL:AAD03462.1 xref: EMBL:AAH01571.1 xref: EMBL:AAH71705.1 xref: EMBL:BAA91352.1 xref: UniProtKB:O00215 xref: UniProtKB:Q99613 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006350 ! EIF3C_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0026357 ! EIF3C_HUMAN-Phosphoserine39 relationship: transforms_into CCO:B0026358 ! EIF3C_HUMAN-Phosphoserine95 relationship: transforms_into CCO:B0026359 ! EIF3C_HUMAN-Phosphoserine166 relationship: transforms_into CCO:B0026360 ! EIF3C_HUMAN-Phosphoserine178 relationship: transforms_into CCO:B0026361 ! EIF3C_HUMAN-Phosphoserine181 relationship: transforms_into CCO:B0026362 ! EIF3C_HUMAN-Phosphoserine182 relationship: transforms_into CCO:B0026363 ! EIF3C_HUMAN-Phosphothreonine524 relationship: transforms_into CCO:B0026364 ! EIF3C_HUMAN-Phosphoserine909 [Term] id: CCO:B0026272 name: EIF3E_HUMAN def: "Eukaryotic translation initiation factor 3 subunit E" [UniProtKB:P60228] synonym: "eIF-3 p48" EXACT [UniProtKB:P60228] synonym: "eIF3e" EXACT [UniProtKB:P60228] synonym: "Eukaryotic translation initiation factor 3 subunit 6" EXACT [UniProtKB:P60228] synonym: "Viral integration site protein INT-6 homolog" EXACT [UniProtKB:P60228] xref: EMBL:AAB58251.1 xref: EMBL:AAB88873.1 xref: EMBL:AAC51760.1 xref: EMBL:AAC51917.1 xref: EMBL:AAC51919.1 xref: EMBL:AAH00734.1 xref: EMBL:AAH08419.1 xref: EMBL:AAH16706.1 xref: EMBL:AAH21679.1 xref: UniProtKB:O43902 xref: UniProtKB:P60228 xref: UniProtKB:Q64058 xref: UniProtKB:Q64059 xref: UniProtKB:Q64252 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006352 ! EIF3E_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0026369 ! EIF3E_HUMAN-Phosphothreonine439 relationship: transforms_into CCO:B0026370 ! EIF3E_HUMAN-Phosphotyrosine445 relationship: transforms_into CCO:B0041300 ! EIF3E_HUMAN-N-acetylalanine2 [Term] id: CCO:B0026273 name: EIF3I_HUMAN def: "Eukaryotic translation initiation factor 3 subunit I" [UniProtKB:Q13347] synonym: "eIF-3-beta" EXACT [UniProtKB:Q13347] synonym: "eIF3 p36" EXACT [UniProtKB:Q13347] synonym: "eIF3i" EXACT [UniProtKB:Q13347] synonym: "Eukaryotic translation initiation factor 3 subunit 2" EXACT [UniProtKB:Q13347] synonym: "TGF-beta receptor-interacting protein 1" EXACT [UniProtKB:Q13347] synonym: "TRIP-1" EXACT [UniProtKB:Q13347] xref: EMBL:AAC50224.1 xref: EMBL:AAC97144.1 xref: EMBL:AAH00413.1 xref: EMBL:AAH03140.1 xref: UniProtKB:Q13347 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006355 ! EIF3I_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0026373 ! EIF3I_HUMAN-Phosphotyrosine308 [Term] id: CCO:B0026274 name: EIF3K_HUMAN def: "Eukaryotic translation initiation factor 3 subunit K" [UniProtKB:Q9UBQ5] synonym: "eIF-3 p25" EXACT [UniProtKB:Q9UBQ5] synonym: "eIF-3 p28" EXACT [UniProtKB:Q9UBQ5] synonym: "eIF3k" EXACT [UniProtKB:Q9UBQ5] synonym: "Eukaryotic translation initiation factor 3 subunit 12" EXACT [UniProtKB:Q9UBQ5] synonym: "Muscle-specific gene M9 protein" EXACT [UniProtKB:Q9UBQ5] synonym: "PLAC-24" EXACT [UniProtKB:Q9UBQ5] xref: EMBL:AAD27784.1 xref: EMBL:AAD40193.1 xref: EMBL:AAH01031.1 xref: EMBL:AAH07335.2 xref: EMBL:AAH07559.1 xref: EMBL:AAK01365.1 xref: EMBL:AAP22070.1 xref: EMBL:AAQ13503.1 xref: EMBL:BAA76626.1 xref: UniProtKB:Q96IQ0 xref: UniProtKB:Q9UBQ5 xref: UniProtKB:Q9Y6D1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006357 ! EIF3K_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0026377 ! EIF3K_HUMAN-Phosphoserine217 [Term] id: CCO:B0026275 name: EIF3B_HUMAN def: "Eukaryotic translation initiation factor 3 subunit B" [UniProtKB:P55884] synonym: "eIF-3-eta" EXACT [UniProtKB:P55884] synonym: "eIF3 p110" EXACT [UniProtKB:P55884] synonym: "eIF3 p116" EXACT [UniProtKB:P55884] synonym: "eIF3b" EXACT [UniProtKB:P55884] synonym: "Eukaryotic translation initiation factor 3 subunit 9" EXACT [UniProtKB:P55884] synonym: "hPrt1" EXACT [UniProtKB:P55884] synonym: "Prt1 homolog" EXACT [UniProtKB:P55884] xref: EMBL:AAB42010.1 xref: EMBL:AAC99479.1 xref: EMBL:AAH01173.1 xref: EMBL:AAI10866.1 xref: UniProtKB:P55884 xref: UniProtKB:Q2NL77 xref: UniProtKB:Q9UMF9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006349 ! EIF3B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007068 ! lrpprc-eif3s8-1 physical interaction relationship: transforms_into CCO:B0026349 ! EIF3B_HUMAN-Phosphoserine83 relationship: transforms_into CCO:B0026350 ! EIF3B_HUMAN-Phosphoserine85 relationship: transforms_into CCO:B0026351 ! EIF3B_HUMAN-Phosphoserine125 relationship: transforms_into CCO:B0026352 ! EIF3B_HUMAN-Phosphoserine152 relationship: transforms_into CCO:B0026353 ! EIF3B_HUMAN-Phosphoserine154 relationship: transforms_into CCO:B0026354 ! EIF3B_HUMAN-Phosphoserine164 relationship: transforms_into CCO:B0026355 ! EIF3B_HUMAN-Phosphothreonine451 relationship: transforms_into CCO:B0026356 ! EIF3B_HUMAN-Phosphotyrosine525 [Term] id: CCO:B0026278 name: EIF3J_HUMAN def: "Eukaryotic translation initiation factor 3 subunit J" [UniProtKB:O75822] synonym: "eIF-3-alpha" EXACT [UniProtKB:O75822] synonym: "eIF3 p35" EXACT [UniProtKB:O75822] synonym: "eIF3j" EXACT [UniProtKB:O75822] synonym: "Eukaryotic translation initiation factor 3 subunit 1" EXACT [UniProtKB:O75822] xref: EMBL:AAC78729.1 xref: EMBL:AAF24039.1 xref: EMBL:AAH02719.1 xref: EMBL:BAB14555.1 xref: UniProtKB:O75822 xref: UniProtKB:Q9BUD2 xref: UniProtKB:Q9H8Q2 xref: UniProtKB:Q9UI65 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006356 ! EIF3J_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008345 ! tpd52l1-eif3s1 physical interaction relationship: transforms_into CCO:B0026374 ! EIF3J_HUMAN-Phosphoserine11 relationship: transforms_into CCO:B0026375 ! EIF3J_HUMAN-Phosphoserine13 relationship: transforms_into CCO:B0026376 ! EIF3J_HUMAN-Phosphothreonine109 relationship: transforms_into CCO:B0041301 ! EIF3J_HUMAN-N-acetylalanine2 [Term] id: CCO:B0026279 name: IF3EI_HUMAN def: "Eukaryotic translation initiation factor 3 subunit E-interacting protein" [UniProtKB:Q9Y262] synonym: "Eukaryotic translation initiation factor 3 subunit 6-interacting protein" EXACT [UniProtKB:Q9Y262] xref: EMBL:AAD27002.1 xref: EMBL:AAD39841.1 xref: EMBL:AAH01101.1 xref: EMBL:AAH07510.1 xref: EMBL:AAH29265.1 xref: EMBL:AAQ13507.1 xref: EMBL:BAD96216.1 xref: EMBL:BAD96249.1 xref: EMBL:CAG30322.1 xref: EMBL:CAI18865.1 xref: EMBL:CAI21418.1 xref: UniProtKB:Q53HQ1 xref: UniProtKB:Q53HT4 xref: UniProtKB:Q5QTR1 xref: UniProtKB:Q5TI15 xref: UniProtKB:Q6ICD2 xref: UniProtKB:Q9Y262 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006362 ! EIF3EIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008470 ! dnm2-eif3s6ip physical interaction [Term] id: CCO:B0026336 name: AAPK1_HUMAN-Phosphoserine487 def: "Protein AAPK1_HUMAN with the residue 487 substituted with Phosphoserine" [UniProtKB:Q13131] xref: UniProtKB:Q13131 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005872 ! AAPK1_HUMAN [Term] id: CCO:B0026337 name: ANDR_HUMAN-Phosphotyrosine223 def: "Protein ANDR_HUMAN with the residue 223 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026338 name: ANDR_HUMAN-Phosphotyrosine267 def: "Protein ANDR_HUMAN with the residue 267 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026339 name: ANDR_HUMAN-Phosphotyrosine307 def: "Protein ANDR_HUMAN with the residue 307 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026340 name: ANDR_HUMAN-Phosphotyrosine346 def: "Protein ANDR_HUMAN with the residue 346 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026341 name: ANDR_HUMAN-Phosphotyrosine357 def: "Protein ANDR_HUMAN with the residue 357 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026342 name: ANDR_HUMAN-Phosphotyrosine362 def: "Protein ANDR_HUMAN with the residue 362 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026343 name: ANDR_HUMAN-Phosphotyrosine363 def: "Protein ANDR_HUMAN with the residue 363 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026344 name: ANDR_HUMAN-Phosphotyrosine393 def: "Protein ANDR_HUMAN with the residue 393 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026345 name: ANDR_HUMAN-Phosphotyrosine534 def: "Protein ANDR_HUMAN with the residue 534 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026346 name: ANDR_HUMAN-Phosphotyrosine551 def: "Protein ANDR_HUMAN with the residue 551 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026347 name: ANDR_HUMAN-Phosphotyrosine915 def: "Protein ANDR_HUMAN with the residue 915 substituted with Phosphotyrosine" [UniProtKB:P10275] comment: by CSK; xref: UniProtKB:P10275 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:B0026348 name: BAT2_HUMAN-Phosphoserine1014 def: "Protein BAT2_HUMAN with the residue 1014 substituted with Phosphoserine" [UniProtKB:P48634] xref: UniProtKB:P48634 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:B0026349 name: EIF3B_HUMAN-Phosphoserine83 def: "Protein EIF3B_HUMAN with the residue 83 substituted with Phosphoserine" [UniProtKB:P55884] xref: UniProtKB:P55884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026275 ! EIF3B_HUMAN [Term] id: CCO:B0026350 name: EIF3B_HUMAN-Phosphoserine85 def: "Protein EIF3B_HUMAN with the residue 85 substituted with Phosphoserine" [UniProtKB:P55884] xref: UniProtKB:P55884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026275 ! EIF3B_HUMAN [Term] id: CCO:B0026351 name: EIF3B_HUMAN-Phosphoserine125 def: "Protein EIF3B_HUMAN with the residue 125 substituted with Phosphoserine" [UniProtKB:P55884] xref: UniProtKB:P55884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026275 ! EIF3B_HUMAN [Term] id: CCO:B0026352 name: EIF3B_HUMAN-Phosphoserine152 def: "Protein EIF3B_HUMAN with the residue 152 substituted with Phosphoserine" [UniProtKB:P55884] xref: UniProtKB:P55884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026275 ! EIF3B_HUMAN [Term] id: CCO:B0026353 name: EIF3B_HUMAN-Phosphoserine154 def: "Protein EIF3B_HUMAN with the residue 154 substituted with Phosphoserine" [UniProtKB:P55884] xref: UniProtKB:P55884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026275 ! EIF3B_HUMAN [Term] id: CCO:B0026354 name: EIF3B_HUMAN-Phosphoserine164 def: "Protein EIF3B_HUMAN with the residue 164 substituted with Phosphoserine" [UniProtKB:P55884] xref: UniProtKB:P55884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026275 ! EIF3B_HUMAN [Term] id: CCO:B0026355 name: EIF3B_HUMAN-Phosphothreonine451 def: "Protein EIF3B_HUMAN with the residue 451 substituted with Phosphothreonine" [UniProtKB:P55884] comment: By similarity xref: UniProtKB:P55884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026275 ! EIF3B_HUMAN [Term] id: CCO:B0026356 name: EIF3B_HUMAN-Phosphotyrosine525 def: "Protein EIF3B_HUMAN with the residue 525 substituted with Phosphotyrosine" [UniProtKB:P55884] xref: UniProtKB:P55884 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026275 ! EIF3B_HUMAN [Term] id: CCO:B0026357 name: EIF3C_HUMAN-Phosphoserine39 def: "Protein EIF3C_HUMAN with the residue 39 substituted with Phosphoserine" [UniProtKB:Q99613] xref: UniProtKB:Q99613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026271 ! EIF3C_HUMAN [Term] id: CCO:B0026358 name: EIF3C_HUMAN-Phosphoserine95 def: "Protein EIF3C_HUMAN with the residue 95 substituted with Phosphoserine" [UniProtKB:Q99613] xref: UniProtKB:Q99613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026271 ! EIF3C_HUMAN [Term] id: CCO:B0026359 name: EIF3C_HUMAN-Phosphoserine166 def: "Protein EIF3C_HUMAN with the residue 166 substituted with Phosphoserine" [UniProtKB:Q99613] xref: UniProtKB:Q99613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026271 ! EIF3C_HUMAN [Term] id: CCO:B0026360 name: EIF3C_HUMAN-Phosphoserine178 def: "Protein EIF3C_HUMAN with the residue 178 substituted with Phosphoserine" [UniProtKB:Q99613] xref: UniProtKB:Q99613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026271 ! EIF3C_HUMAN [Term] id: CCO:B0026361 name: EIF3C_HUMAN-Phosphoserine181 def: "Protein EIF3C_HUMAN with the residue 181 substituted with Phosphoserine" [UniProtKB:Q99613] xref: UniProtKB:Q99613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026271 ! EIF3C_HUMAN [Term] id: CCO:B0026362 name: EIF3C_HUMAN-Phosphoserine182 def: "Protein EIF3C_HUMAN with the residue 182 substituted with Phosphoserine" [UniProtKB:Q99613] xref: UniProtKB:Q99613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026271 ! EIF3C_HUMAN [Term] id: CCO:B0026363 name: EIF3C_HUMAN-Phosphothreonine524 def: "Protein EIF3C_HUMAN with the residue 524 substituted with Phosphothreonine" [UniProtKB:Q99613] xref: UniProtKB:Q99613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026271 ! EIF3C_HUMAN [Term] id: CCO:B0026364 name: EIF3C_HUMAN-Phosphoserine909 def: "Protein EIF3C_HUMAN with the residue 909 substituted with Phosphoserine" [UniProtKB:Q99613] xref: UniProtKB:Q99613 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026271 ! EIF3C_HUMAN [Term] id: CCO:B0026365 name: EIF3D_HUMAN-Phosphoserine67 def: "Protein EIF3D_HUMAN with the residue 67 substituted with Phosphoserine" [UniProtKB:O15371] xref: UniProtKB:O15371 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026270 ! EIF3D_HUMAN [Term] id: CCO:B0026366 name: EIF3D_HUMAN-Phosphotyrosine318 def: "Protein EIF3D_HUMAN with the residue 318 substituted with Phosphotyrosine" [UniProtKB:O15371] xref: UniProtKB:O15371 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026270 ! EIF3D_HUMAN [Term] id: CCO:B0026367 name: EIF3D_HUMAN-Phosphoserine528 def: "Protein EIF3D_HUMAN with the residue 528 substituted with Phosphoserine" [UniProtKB:O15371] xref: UniProtKB:O15371 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026270 ! EIF3D_HUMAN [Term] id: CCO:B0026368 name: EIF3D_HUMAN-Phosphoserine529 def: "Protein EIF3D_HUMAN with the residue 529 substituted with Phosphoserine" [UniProtKB:O15371] xref: UniProtKB:O15371 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026270 ! EIF3D_HUMAN [Term] id: CCO:B0026369 name: EIF3E_HUMAN-Phosphothreonine439 def: "Protein EIF3E_HUMAN with the residue 439 substituted with Phosphothreonine" [UniProtKB:P60228] comment: By similarity xref: UniProtKB:P60228 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026272 ! EIF3E_HUMAN [Term] id: CCO:B0026370 name: EIF3E_HUMAN-Phosphotyrosine445 def: "Protein EIF3E_HUMAN with the residue 445 substituted with Phosphotyrosine" [UniProtKB:P60228] xref: UniProtKB:P60228 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026272 ! EIF3E_HUMAN [Term] id: CCO:B0026371 name: EIF3G_HUMAN-Phosphothreonine41 def: "Protein EIF3G_HUMAN with the residue 41 substituted with Phosphothreonine" [UniProtKB:O75821] xref: UniProtKB:O75821 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026269 ! EIF3G_HUMAN [Term] id: CCO:B0026372 name: EIF3G_HUMAN-Phosphoserine42 def: "Protein EIF3G_HUMAN with the residue 42 substituted with Phosphoserine" [UniProtKB:O75821] xref: UniProtKB:O75821 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026269 ! EIF3G_HUMAN [Term] id: CCO:B0026373 name: EIF3I_HUMAN-Phosphotyrosine308 def: "Protein EIF3I_HUMAN with the residue 308 substituted with Phosphotyrosine" [UniProtKB:Q13347] xref: UniProtKB:Q13347 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026273 ! EIF3I_HUMAN [Term] id: CCO:B0026374 name: EIF3J_HUMAN-Phosphoserine11 def: "Protein EIF3J_HUMAN with the residue 11 substituted with Phosphoserine" [UniProtKB:O75822] xref: UniProtKB:O75822 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026278 ! EIF3J_HUMAN [Term] id: CCO:B0026375 name: EIF3J_HUMAN-Phosphoserine13 def: "Protein EIF3J_HUMAN with the residue 13 substituted with Phosphoserine" [UniProtKB:O75822] xref: UniProtKB:O75822 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026278 ! EIF3J_HUMAN [Term] id: CCO:B0026376 name: EIF3J_HUMAN-Phosphothreonine109 def: "Protein EIF3J_HUMAN with the residue 109 substituted with Phosphothreonine" [UniProtKB:O75822] xref: UniProtKB:O75822 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026278 ! EIF3J_HUMAN [Term] id: CCO:B0026377 name: EIF3K_HUMAN-Phosphoserine217 def: "Protein EIF3K_HUMAN with the residue 217 substituted with Phosphoserine" [UniProtKB:Q9UBQ5] xref: UniProtKB:Q9UBQ5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026274 ! EIF3K_HUMAN [Term] id: CCO:B0026378 name: GRLF1_HUMAN-Phosphoserine1150 def: "Protein GRLF1_HUMAN with the residue 1150 substituted with Phosphoserine" [UniProtKB:Q9NRY4] xref: UniProtKB:Q9NRY4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002160 ! GRLF1_HUMAN [Term] id: CCO:B0026379 name: H2AX_HUMAN-Phosphothreonine121 def: "Protein H2AX_HUMAN with the residue 121 substituted with Phosphothreonine" [UniProtKB:P16104] xref: UniProtKB:P16104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:B0026380 name: JUB_HUMAN-Phosphoserine119 def: "Protein JUB_HUMAN with the residue 119 substituted with Phosphoserine" [UniProtKB:Q96IF1] xref: UniProtKB:Q96IF1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000421 ! cytoskeleton relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000936 ! cell junction relationship: transformation_of CCO:B0026254 ! JUB_HUMAN [Term] id: CCO:B0026381 name: JUB_HUMAN-Phosphoserine263 def: "Protein JUB_HUMAN with the residue 263 substituted with Phosphoserine" [UniProtKB:Q96IF1] xref: UniProtKB:Q96IF1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026254 ! JUB_HUMAN [Term] id: CCO:B0026382 name: NF1_HUMAN-Phosphoserine2829 def: "Protein NF1_HUMAN with the residue 2829 substituted with Phosphoserine" [UniProtKB:P21359] xref: UniProtKB:P21359 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001542 ! NF1_HUMAN [Term] id: CCO:B0026383 name: NUCL_HUMAN-Phosphothreonine99 def: "Protein NUCL_HUMAN with the residue 99 substituted with Phosphothreonine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0026384 name: NUCL_HUMAN-Phosphothreonine105 def: "Protein NUCL_HUMAN with the residue 105 substituted with Phosphothreonine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0026385 name: PDS5B_HUMAN-Phosphoserine1166 def: "Protein PDS5B_HUMAN with the residue 1166 substituted with Phosphoserine" [UniProtKB:Q9NTI5] xref: UniProtKB:Q9NTI5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026257 ! PDS5B_HUMAN [Term] id: CCO:B0026386 name: PDS5B_HUMAN-Phosphoserine1257 def: "Protein PDS5B_HUMAN with the residue 1257 substituted with Phosphoserine" [UniProtKB:Q9NTI5] xref: UniProtKB:Q9NTI5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026257 ! PDS5B_HUMAN [Term] id: CCO:B0026387 name: PDS5B_HUMAN-Phosphoserine1259 def: "Protein PDS5B_HUMAN with the residue 1259 substituted with Phosphoserine" [UniProtKB:Q9NTI5] comment: By similarity xref: UniProtKB:Q9NTI5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026257 ! PDS5B_HUMAN [Term] id: CCO:B0026388 name: PDS5B_HUMAN-Phosphoserine1358 def: "Protein PDS5B_HUMAN with the residue 1358 substituted with Phosphoserine" [UniProtKB:Q9NTI5] xref: UniProtKB:Q9NTI5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026257 ! PDS5B_HUMAN [Term] id: CCO:B0026389 name: PDS5B_HUMAN-Phosphothreonine1367 def: "Protein PDS5B_HUMAN with the residue 1367 substituted with Phosphothreonine" [UniProtKB:Q9NTI5] xref: UniProtKB:Q9NTI5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026257 ! PDS5B_HUMAN [Term] id: CCO:B0026390 name: PDS5B_HUMAN-Phosphothreonine1370 def: "Protein PDS5B_HUMAN with the residue 1370 substituted with Phosphothreonine" [UniProtKB:Q9NTI5] xref: UniProtKB:Q9NTI5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026257 ! PDS5B_HUMAN [Term] id: CCO:B0026391 name: PDS5B_HUMAN-Phosphoserine1383 def: "Protein PDS5B_HUMAN with the residue 1383 substituted with Phosphoserine" [UniProtKB:Q9NTI5] xref: UniProtKB:Q9NTI5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026257 ! PDS5B_HUMAN [Term] id: CCO:B0026393 name: ZMY11_HUMAN-Phosphoserine381 def: "Protein ZMY11_HUMAN with the residue 381 substituted with Phosphoserine" [UniProtKB:Q15326] xref: UniProtKB:Q15326 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026249 ! ZMY11_HUMAN [Term] id: CCO:B0028285 name: A8MT51_HUMAN def: "Septin" [UniProtKB:A8MT51] xref: UniProtKB:A8MT51 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0028502 name: ERCC3_HUMAN def: "TFIIH basal transcription factor complex helicase XPB subunit" [UniProtKB:P19447] synonym: "Basic transcription factor 2 89 kDa subunit" EXACT [UniProtKB:P19447] synonym: "BTF2-p89" EXACT [UniProtKB:P19447] synonym: "DNA excision repair protein ERCC-3" EXACT [UniProtKB:P19447] synonym: "DNA-repair protein complementing XP-B cells" EXACT [UniProtKB:P19447] synonym: "EC 3.6.1.-" EXACT [UniProtKB:P19447] synonym: "TFIIH 89 kDa subunit" EXACT [UniProtKB:P19447] synonym: "Xeroderma pigmentosum group B-complementing protein" EXACT [UniProtKB:P19447] xref: EMBL:AAA52396.1 xref: EMBL:AAH08820.1 xref: EMBL:AAN46739.1 xref: UniProtKB:P19447 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0010893 ! ERCC3_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000279 ! damaged DNA binding relationship: has_function CCO:F0000487 ! ATP-dependent DNA helicase activity relationship: has_function CCO:F0000803 ! helicase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0001681 ! protein C-terminus binding relationship: has_function CCO:F0001707 ! DNA-dependent ATPase activity relationship: has_function CCO:F0001738 ! transcription factor binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0003445 ! ATPase activity relationship: has_function CCO:F0005800 ! 3'-5' DNA helicase activity relationship: has_function CCO:F0006791 ! protein N-terminus binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000279 ! holo TFIIH complex relationship: participates_in CCO:P0000006 ! cell cycle checkpoint relationship: transforms_into CCO:B0036002 ! ERCC3_HUMAN-Phosphoserine370 [Term] id: CCO:B0030400 name: A8K7M3_HUMAN def: "cDNA FLJ78458, highly similar to Homo sapiens septin 10 (SEPT10), transcript variant 1, mRNA" [UniProtKB:A8K7M3] xref: EMBL:BAF84727.1 xref: UniProtKB:A8K7M3 is_a: CCO:B0000000 ! core cell cycle protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0030750 name: CSN3_HUMAN def: "COP9 signalosome complex subunit 3" [UniProtKB:Q9UNS2] synonym: "JAB1-containing signalosome subunit 3" EXACT [UniProtKB:Q9UNS2] synonym: "SGN3" EXACT [UniProtKB:Q9UNS2] synonym: "Signalosome subunit 3" EXACT [UniProtKB:Q9UNS2] xref: EMBL:AAC14197.1 xref: EMBL:AAD41247.1 xref: EMBL:AAH01891.1 xref: UniProtKB:O43191 xref: UniProtKB:Q7LDR6 xref: UniProtKB:Q9UNS2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006401 ! COPS3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008528 ! ddb1-cops3 physical interaction relationship: transforms_into CCO:B0030752 ! CSN3_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0030753 ! CSN3_HUMAN-Phosphoserine410 [Term] id: CCO:B0030751 name: VAMP3_HUMAN def: "Vesicle-associated membrane protein 3" [UniProtKB:Q15836] synonym: "CEB" EXACT [UniProtKB:Q15836] synonym: "Cellubrevin" EXACT [UniProtKB:Q15836] synonym: "Synaptobrevin-3" EXACT [UniProtKB:Q15836] synonym: "VAMP-3" EXACT [UniProtKB:Q15836] xref: EMBL:AAB05814.1 xref: EMBL:AAH03570.1 xref: EMBL:AAH07050.1 xref: EMBL:AAP35991.1 xref: EMBL:CAB63146.1 xref: UniProtKB:Q15836 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006402 ! VAMP3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008535 ! vamp3-ddb1 physical interaction relationship: transforms_into CCO:B0030754 ! VAMP3_HUMAN-Phosphoserine58 [Term] id: CCO:B0030752 name: CSN3_HUMAN-N-acetylalanine2 def: "Protein CSN3_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9UNS2] xref: UniProtKB:Q9UNS2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0030750 ! CSN3_HUMAN [Term] id: CCO:B0030753 name: CSN3_HUMAN-Phosphoserine410 def: "Protein CSN3_HUMAN with the residue 410 substituted with Phosphoserine" [UniProtKB:Q9UNS2] xref: UniProtKB:Q9UNS2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0030750 ! CSN3_HUMAN [Term] id: CCO:B0030754 name: VAMP3_HUMAN-Phosphoserine58 def: "Protein VAMP3_HUMAN with the residue 58 substituted with Phosphoserine" [UniProtKB:Q15836] xref: UniProtKB:Q15836 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0030751 ! VAMP3_HUMAN [Term] id: CCO:B0030768 name: PSA7_HUMAN def: "Proteasome subunit alpha type-7" [UniProtKB:O14818] synonym: "EC 3.4.25.1" EXACT [UniProtKB:O14818] synonym: "Proteasome subunit RC6-1" EXACT [UniProtKB:O14818] synonym: "Proteasome subunit XAPC7" EXACT [UniProtKB:O14818] xref: EMBL:AAB81515.1 xref: EMBL:AAC99402.1 xref: EMBL:AAH04427.1 xref: EMBL:AAP35829.1 xref: EMBL:CAC04017.1 xref: EMBL:CAC04018.1 xref: UniProtKB:O14818 xref: UniProtKB:Q9BR53 xref: UniProtKB:Q9H4K5 xref: UniProtKB:Q9UEU8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008019 ! PSMA7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008725 ! alpha1-alpha7 physical interaction relationship: participates_in CCO:I0008734 ! alpha4-alpha7 physical interaction relationship: participates_in CCO:I0008736 ! alpha6-alpha7 physical interaction relationship: participates_in CCO:I0008737 ! alpha7-alpha1 physical interaction relationship: participates_in CCO:I0008738 ! alpha7-alpha4 physical interaction relationship: participates_in CCO:I0008739 ! alpha7-alpha6 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0035477 ! PSA7_HUMAN-N-acetylserine2 [Term] id: CCO:B0030800 name: PSB2_HUMAN def: "Proteasome subunit beta type-2" [UniProtKB:P49721] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P49721] synonym: "Macropain subunit C7-I" EXACT [UniProtKB:P49721] synonym: "Multicatalytic endopeptidase complex subunit C7-I" EXACT [UniProtKB:P49721] synonym: "Proteasome component C7-I" EXACT [UniProtKB:P49721] xref: EMBL:AAI01837.1 xref: EMBL:AAI05127.1 xref: EMBL:AAI07902.1 xref: EMBL:AAP35801.1 xref: EMBL:BAA05646.1 xref: EMBL:CAC36031.2 xref: EMBL:CAG33143.1 xref: EMBL:CAI22074.1 xref: EMBL:CAI23521.1 xref: UniProtKB:P31145 xref: UniProtKB:P49721 xref: UniProtKB:Q9BWZ9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008021 ! PSMB2_human relationship: has_function CCO:F0000721 ! threonine endopeptidase activity relationship: has_function CCO:F0001783 ! peptidase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: located_in CCO:C0002080 ! proteasome core complex relationship: participates_in CCO:I0008710 ! traf6-psmb2 physical interaction relationship: participates_in CCO:I0008726 ! alpha1-beta2 physical interaction relationship: participates_in CCO:I0008740 ! beta2-beta3 physical interaction relationship: participates_in CCO:I0008749 ! beta3-beta2 physical interaction relationship: participates_in CCO:I0008751 ! beta5-beta2 physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0035479 ! PSB2_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0030804 name: PSB8_HUMAN def: "Proteasome subunit beta type-8 precursor" [UniProtKB:P28062] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P28062] synonym: "Macropain subunit C13" EXACT [UniProtKB:P28062] synonym: "Multicatalytic endopeptidase complex subunit C13" EXACT [UniProtKB:P28062] synonym: "Proteasome component C13" EXACT [UniProtKB:P28062] synonym: "Proteasome subunit beta-5i" EXACT [UniProtKB:P28062] xref: EMBL:AAA56777.1 xref: EMBL:AAA56778.1 xref: EMBL:AAA80234.1 xref: EMBL:AAA80235.1 xref: EMBL:AAH01114.1 xref: EMBL:CAA44482.1 xref: EMBL:CAA47026.1 xref: EMBL:CAA60786.1 xref: EMBL:CAA60787.1 xref: EMBL:CAA78705.1 xref: EMBL:CAA78706.1 xref: EMBL:CAI18139.1 xref: UniProtKB:P28062 xref: UniProtKB:Q29824 xref: UniProtKB:Q96J48 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0011632 ! PSMB8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008721 ! lsm1-psmb8 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0030806 name: PSB5_HUMAN def: "Proteasome subunit beta type-5 precursor" [UniProtKB:P28074] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P28074] synonym: "Macropain epsilon chain" EXACT [UniProtKB:P28074] synonym: "Multicatalytic endopeptidase complex epsilon chain" EXACT [UniProtKB:P28074] synonym: "Proteasome chain 6" EXACT [UniProtKB:P28074] synonym: "Proteasome epsilon chain" EXACT [UniProtKB:P28074] synonym: "Proteasome subunit MB1" EXACT [UniProtKB:P28074] synonym: "Proteasome subunit X" EXACT [UniProtKB:P28074] xref: EMBL:AAB33092.1 xref: EMBL:AAH57840.1 xref: EMBL:AAI07721.1 xref: EMBL:AAP35423.1 xref: EMBL:BAA06097.1 xref: EMBL:CAA64838.1 xref: EMBL:CAD97956.1 xref: UniProtKB:P28074 xref: UniProtKB:Q16242 xref: UniProtKB:Q6PEW2 xref: UniProtKB:Q7Z3B5 xref: UniProtKB:Q9TNN9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0011631 ! PSMB5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008713 ! traf6-psmb5 physical interaction relationship: participates_in CCO:I0008722 ! lsm1-psmb5 physical interaction relationship: participates_in CCO:I0008743 ! beta1-beta5 physical interaction relationship: participates_in CCO:I0008750 ! beta5-beta1 physical interaction relationship: participates_in CCO:I0008751 ! beta5-beta2 physical interaction relationship: participates_in CCO:I0008752 ! beta5-beta3 physical interaction relationship: participates_in CCO:I0008753 ! beta5-alpha3 physical interaction relationship: participates_in CCO:I0008754 ! beta5-beta7 physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0030810 name: Q5JNW7_HUMAN def: "Proteasome (Prosome, macropain) subunit, beta type, 8" [UniProtKB:Q5JNW7] synonym: "Large multifunctional peptidase 7" EXACT [UniProtKB:Q5JNW7] synonym: "Large multifunctional protease 7" EXACT [UniProtKB:Q5JNW7] xref: EMBL:CAI18624.1 xref: EMBL:CAM24978.1 xref: EMBL:CAM25484.1 xref: EMBL:CAM25946.1 xref: EMBL:CAM26260.1 xref: EMBL:CAQ07780.1 xref: EMBL:CAQ08446.1 xref: EMBL:CAQ08493.1 xref: UniProtKB:Q5JNW7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0011632 ! PSMB8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008744 ! beta1-beta5i physical interaction relationship: participates_in CCO:I0008746 ! beta1i-beta5i physical interaction relationship: participates_in CCO:I0008755 ! beta5i-beta7 physical interaction relationship: participates_in CCO:I0008759 ! beta7-beta5i physical interaction [Term] id: CCO:B0030905 name: PRS10_HUMAN def: "26S protease regulatory subunit S10B" [UniProtKB:P62333] synonym: "Proteasome 26S subunit ATPase 6" EXACT [UniProtKB:P62333] synonym: "Proteasome subunit p42" EXACT [UniProtKB:P62333] xref: EMBL:AAB61616.1 xref: EMBL:AAH05390.1 xref: EMBL:AAP35489.1 xref: EMBL:BAA11338.1 xref: EMBL:CAG32990.1 xref: UniProtKB:P49719 xref: UniProtKB:P62333 xref: UniProtKB:Q6IBU3 xref: UniProtKB:Q92524 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0011629 ! PSMC6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008689 ! flj38984-psmc6 physical interaction relationship: participates_in CCO:I0008691 ! psmc6-psmd9 physical interaction relationship: participates_in CCO:I0008707 ! traf6-psmc6 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0039597 ! PRS10_HUMAN-N-acetylalanine2 [Term] id: CCO:B0030929 name: PSB3_HUMAN def: "Proteasome subunit beta type-3" [UniProtKB:P49720] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P49720] synonym: "Proteasome chain 13" EXACT [UniProtKB:P49720] synonym: "Proteasome component C10-II" EXACT [UniProtKB:P49720] synonym: "Proteasome theta chain" EXACT [UniProtKB:P49720] xref: EMBL:AAH02570.1 xref: EMBL:AAH13008.1 xref: EMBL:BAA05645.1 xref: UniProtKB:P31147 xref: UniProtKB:P49720 xref: UniProtKB:Q0P6J7 xref: UniProtKB:Q96E27 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008022 ! PSMB3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008740 ! beta2-beta3 physical interaction relationship: participates_in CCO:I0008741 ! beta1-beta3 physical interaction relationship: participates_in CCO:I0008747 ! beta2i-beta3 physical interaction relationship: participates_in CCO:I0008748 ! beta3-beta2i physical interaction relationship: participates_in CCO:I0008749 ! beta3-beta2 physical interaction relationship: participates_in CCO:I0008752 ! beta5-beta3 physical interaction relationship: participates_in CCO:I0008757 ! beta7-beta3 physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0035480 ! PSB3_HUMAN-N-acetylserine2 [Term] id: CCO:B0030961 name: PSB1_HUMAN def: "Proteasome subunit beta type-1 precursor" [UniProtKB:P20618] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P20618] synonym: "Macropain subunit C5" EXACT [UniProtKB:P20618] synonym: "Multicatalytic endopeptidase complex subunit C5" EXACT [UniProtKB:P20618] synonym: "Proteasome component C5" EXACT [UniProtKB:P20618] synonym: "Proteasome gamma chain" EXACT [UniProtKB:P20618] xref: EMBL:AAH00508.1 xref: EMBL:AAH20807.1 xref: EMBL:AAV38525.1 xref: EMBL:BAA00658.1 xref: EMBL:CAA20287.1 xref: UniProtKB:P20618 xref: UniProtKB:Q9BWA8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008020 ! PSMB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008741 ! beta1-beta3 physical interaction relationship: participates_in CCO:I0008742 ! beta1-beta7 physical interaction relationship: participates_in CCO:I0008743 ! beta1-beta5 physical interaction relationship: participates_in CCO:I0008744 ! beta1-beta5i physical interaction relationship: participates_in CCO:I0008750 ! beta5-beta1 physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0035478 ! PSB1_HUMAN-Phosphotyrosine150 [Term] id: CCO:B0031003 name: PSD7_HUMAN def: "26S proteasome non-ATPase regulatory subunit 7" [UniProtKB:P51665] synonym: "26S proteasome regulatory subunit rpn8" EXACT [UniProtKB:P51665] synonym: "26S proteasome regulatory subunit S12" EXACT [UniProtKB:P51665] synonym: "Mov34 protein homolog" EXACT [UniProtKB:P51665] synonym: "Proteasome subunit p40" EXACT [UniProtKB:P51665] xref: EMBL:AAH00338.1 xref: EMBL:AAH12606.1 xref: EMBL:BAA08780.1 xref: UniProtKB:P51665 xref: UniProtKB:Q6PKI2 xref: UniProtKB:Q96E97 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008027 ! PSMD7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008719 ! traf6-psmd7 physical interaction relationship: participates_in CCO:I0008824 ! rab1a-psmd7 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0035483 ! PSD7_HUMAN-Phosphothreonine186 [Term] id: CCO:B0031007 name: PSB9_HUMAN def: "Proteasome subunit beta type-9 precursor" [UniProtKB:P28065] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P28065] synonym: "Low molecular mass protein 2" EXACT [UniProtKB:P28065] synonym: "Macropain chain 7" EXACT [UniProtKB:P28065] synonym: "Multicatalytic endopeptidase complex chain 7" EXACT [UniProtKB:P28065] synonym: "Proteasome chain 7" EXACT [UniProtKB:P28065] synonym: "Proteasome subunit beta-1i" EXACT [UniProtKB:P28065] synonym: "RING12 protein" EXACT [UniProtKB:P28065] xref: EMBL:AAC50154.1 xref: EMBL:AAC60646.1 xref: EMBL:AAH65513.1 xref: EMBL:CAA44603.1 xref: EMBL:CAA47024.1 xref: EMBL:CAA60784.1 xref: EMBL:CAA78700.1 xref: EMBL:CAI18141.1 xref: UniProtKB:P28065 xref: UniProtKB:Q16523 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008025 ! PSMB9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008745 ! beta1i-beta7 physical interaction relationship: participates_in CCO:I0008746 ! beta1i-beta5i physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0031015 name: PSB6_HUMAN def: "Proteasome subunit beta type-6 precursor" [UniProtKB:P28072] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P28072] synonym: "Macropain delta chain" EXACT [UniProtKB:P28072] synonym: "Multicatalytic endopeptidase complex delta chain" EXACT [UniProtKB:P28072] synonym: "Proteasome delta chain" EXACT [UniProtKB:P28072] synonym: "Proteasome subunit Y" EXACT [UniProtKB:P28072] xref: EMBL:AAH00835.1 xref: EMBL:BAA06098.1 xref: EMBL:CAA43963.1 xref: UniProtKB:P28072 xref: UniProtKB:Q96J55 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008023 ! PSMB6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008705 ! traf6-psmb6 physical interaction relationship: participates_in CCO:I0008756 ! beta6-beta7 physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:I0008804 ! ezh2-psmb6 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0031197 name: RFXD1_HUMAN def: "Regulatory factor X domain-containing protein 1" [UniProtKB:Q8HWS3] xref: EMBL:AAH39248.1 xref: EMBL:CAI23444.2 xref: EMBL:EAW48213.1 xref: UniProtKB:Q5T6B3 xref: UniProtKB:Q8HWS3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006016 ! RFXDC1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005784 ! ccnk-rfxdc1 physical interaction [Term] id: CCO:B0031198 name: MOBL3_HUMAN def: "Mps one binder kinase activator-like 3" [UniProtKB:Q9Y3A3] synonym: "2C4D" EXACT [UniProtKB:Q9Y3A3] synonym: "Class II mMOB1" EXACT [UniProtKB:Q9Y3A3] synonym: "Mob1 homolog 3" EXACT [UniProtKB:Q9Y3A3] synonym: "Mob3" EXACT [UniProtKB:Q9Y3A3] synonym: "Preimplantation protein 3" EXACT [UniProtKB:Q9Y3A3] xref: EMBL:AAD34090.1 xref: EMBL:AAG44567.1 xref: EMBL:AAH05237.1 xref: EMBL:AAP97221.1 xref: EMBL:BAB15635.1 xref: EMBL:BAB19057.1 xref: EMBL:CAB45697.1 xref: EMBL:CAE45270.1 xref: EMBL:CAG33652.1 xref: UniProtKB:Q7Z4Y6 xref: UniProtKB:Q9H2P3 xref: UniProtKB:Q9H5J1 xref: UniProtKB:Q9Y3A3 xref: UniProtKB:Q9Y4T8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006414 ! MOBKL3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008152 ! prei3-mcm2 physical interaction relationship: participates_in CCO:I0008153 ! prei3-rif1 physical interaction relationship: participates_in CCO:I0008491 ! prei3-stk11 physical interaction [Term] id: CCO:B0031284 name: 1433F_HUMAN-Phosphotyrosine117 def: "Protein 1433F_HUMAN with the residue 117 substituted with Phosphotyrosine" [UniProtKB:Q04917] comment: By similarity xref: UniProtKB:Q04917 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005490 ! 1433F_HUMAN [Term] id: CCO:B0031285 name: 1433G_HUMAN-Phosphotyrosine117 def: "Protein 1433G_HUMAN with the residue 117 substituted with Phosphotyrosine" [UniProtKB:P61981] comment: By similarity xref: UniProtKB:P61981 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005489 ! 1433G_HUMAN [Term] id: CCO:B0031286 name: ABI1_HUMAN-Phosphotyrosine455 def: "Protein ABI1_HUMAN with the residue 455 substituted with Phosphotyrosine" [UniProtKB:Q8IZP0] comment: By similarity xref: UniProtKB:Q8IZP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005703 ! ABI1_HUMAN [Term] id: CCO:B0031287 name: ADT2_HUMAN-Phosphotyrosine191 def: "Protein ADT2_HUMAN with the residue 191 substituted with Phosphotyrosine" [UniProtKB:P05141] comment: By similarity xref: UniProtKB:P05141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005813 ! ADT2_HUMAN [Term] id: CCO:B0031288 name: ADT2_HUMAN-Phosphotyrosine195 def: "Protein ADT2_HUMAN with the residue 195 substituted with Phosphotyrosine" [UniProtKB:P05141] comment: By similarity xref: UniProtKB:P05141 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005813 ! ADT2_HUMAN [Term] id: CCO:B0031289 name: AF1L2_HUMAN-Phosphotyrosine56 def: "Protein AF1L2_HUMAN with the residue 56 substituted with Phosphotyrosine" [UniProtKB:Q8N4X5] comment: By similarity xref: UniProtKB:Q8N4X5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001964 ! AF1L2_HUMAN [Term] id: CCO:B0031290 name: ANC2_HUMAN-Phosphotyrosine810 def: "Protein ANC2_HUMAN with the residue 810 substituted with Phosphotyrosine" [UniProtKB:Q9UJX6] comment: By similarity xref: UniProtKB:Q9UJX6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002216 ! ANC2_HUMAN [Term] id: CCO:B0031291 name: ANXA6_HUMAN-Phosphotyrosine30 def: "Protein ANXA6_HUMAN with the residue 30 substituted with Phosphotyrosine" [UniProtKB:P08133] comment: By similarity xref: UniProtKB:P08133 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005731 ! ANXA6_HUMAN [Term] id: CCO:B0031292 name: ANXA6_HUMAN-Phosphotyrosine201 def: "Protein ANXA6_HUMAN with the residue 201 substituted with Phosphotyrosine" [UniProtKB:P08133] comment: By similarity xref: UniProtKB:P08133 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005731 ! ANXA6_HUMAN [Term] id: CCO:B0031293 name: AP2B1_HUMAN-Phosphotyrosine888 def: "Protein AP2B1_HUMAN with the residue 888 substituted with Phosphotyrosine" [UniProtKB:P63010] comment: By similarity xref: UniProtKB:P63010 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005197 ! AP2B1_HUMAN [Term] id: CCO:B0031294 name: ARPC3_HUMAN-Phosphotyrosine47 def: "Protein ARPC3_HUMAN with the residue 47 substituted with Phosphotyrosine" [UniProtKB:O15145] comment: By similarity xref: UniProtKB:O15145 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006172 ! ARPC3_HUMAN [Term] id: CCO:B0031295 name: AT1A1_HUMAN-Phosphotyrosine260 def: "Protein AT1A1_HUMAN with the residue 260 substituted with Phosphotyrosine" [UniProtKB:P05023] comment: By similarity xref: UniProtKB:P05023 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005459 ! AT1A1_HUMAN [Term] id: CCO:B0031296 name: AT1B1_HUMAN-Phosphotyrosine101 def: "Protein AT1B1_HUMAN with the residue 101 substituted with Phosphotyrosine" [UniProtKB:P05026] comment: By similarity xref: UniProtKB:P05026 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005453 ! AT1B1_HUMAN [Term] id: CCO:B0031297 name: BCR_HUMAN-Phosphoserine236 def: "Protein BCR_HUMAN with the residue 236 substituted with Phosphoserine" [UniProtKB:P11274] comment: By similarity xref: UniProtKB:P11274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:B0031298 name: BCR_HUMAN-Phosphotyrosine246 def: "Protein BCR_HUMAN with the residue 246 substituted with Phosphotyrosine" [UniProtKB:P11274] comment: By similarity xref: UniProtKB:P11274 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:B0031299 name: BEGIN_HUMAN-Phosphotyrosine137 def: "Protein BEGIN_HUMAN with the residue 137 substituted with Phosphotyrosine" [UniProtKB:Q9BUH8] comment: By similarity xref: UniProtKB:Q9BUH8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:B0031300 name: CBL_HUMAN-Phosphoserine668 def: "Protein CBL_HUMAN with the residue 668 substituted with Phosphoserine" [UniProtKB:P22681] comment: By similarity xref: UniProtKB:P22681 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:B0031306 name: CS025_HUMAN-Phosphotyrosine63 def: "Protein CS025_HUMAN with the residue 63 substituted with Phosphotyrosine" [UniProtKB:Q9UFG5] comment: By similarity xref: UniProtKB:Q9UFG5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006066 ! CS025_HUMAN [Term] id: CCO:B0031307 name: CTND1_HUMAN-Phosphotyrosine904 def: "Protein CTND1_HUMAN with the residue 904 substituted with Phosphotyrosine" [UniProtKB:O60716] comment: By similarity xref: UniProtKB:O60716 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005839 ! CTND1_HUMAN [Term] id: CCO:B0031308 name: CTRO_HUMAN-Phosphotyrosine1196 def: "Protein CTRO_HUMAN with the residue 1196 substituted with Phosphotyrosine" [UniProtKB:O14578] comment: By similarity xref: UniProtKB:O14578 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001356 ! CTRO_HUMAN [Term] id: CCO:B0031309 name: CTRO_HUMAN-Phosphotyrosine1478 def: "Protein CTRO_HUMAN with the residue 1478 substituted with Phosphotyrosine" [UniProtKB:O14578] comment: By similarity xref: UniProtKB:O14578 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001356 ! CTRO_HUMAN [Term] id: CCO:B0031310 name: DCTN2_HUMAN-Phosphotyrosine86 def: "Protein DCTN2_HUMAN with the residue 86 substituted with Phosphotyrosine" [UniProtKB:Q13561] comment: By similarity xref: UniProtKB:Q13561 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005177 ! DCTN2_HUMAN [Term] id: CCO:B0031311 name: DLG1_HUMAN-Phosphotyrosine399 def: "Protein DLG1_HUMAN with the residue 399 substituted with Phosphotyrosine" [UniProtKB:Q12959] comment: By similarity xref: UniProtKB:Q12959 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001736 ! DLG1_HUMAN [Term] id: CCO:B0031312 name: DPYL1_HUMAN-Phosphotyrosine431 def: "Protein DPYL1_HUMAN with the residue 431 substituted with Phosphotyrosine" [UniProtKB:Q14194] comment: By similarity xref: UniProtKB:Q14194 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006074 ! DPYL1_HUMAN [Term] id: CCO:B0031313 name: DPYL1_HUMAN-Phosphotyrosine504 def: "Protein DPYL1_HUMAN with the residue 504 substituted with Phosphotyrosine" [UniProtKB:Q14194] comment: By similarity xref: UniProtKB:Q14194 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006074 ! DPYL1_HUMAN [Term] id: CCO:B0031315 name: ENOG_HUMAN-Phosphotyrosine25 def: "Protein ENOG_HUMAN with the residue 25 substituted with Phosphotyrosine" [UniProtKB:P09104] comment: By similarity xref: UniProtKB:P09104 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006270 ! ENOG_HUMAN [Term] id: CCO:B0031316 name: FAK2_HUMAN-Phosphotyrosine440 def: "Protein FAK2_HUMAN with the residue 440 substituted with Phosphotyrosine" [UniProtKB:Q14289] comment: By similarity xref: UniProtKB:Q14289 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005846 ! FAK2_HUMAN [Term] id: CCO:B0031317 name: FGFR3_HUMAN-Phosphotyrosine647 def: "Protein FGFR3_HUMAN with the residue 647 substituted with Phosphotyrosine" [UniProtKB:P22607] comment: By similarity xref: UniProtKB:P22607 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005920 ! FGFR3_HUMAN [Term] id: CCO:B0031318 name: FNBP1_HUMAN-Phosphoserine497 def: "Protein FNBP1_HUMAN with the residue 497 substituted with Phosphoserine" [UniProtKB:Q96RU3] comment: By similarity xref: UniProtKB:Q96RU3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005386 ! FNBP1_HUMAN [Term] id: CCO:B0031319 name: FNBP1_HUMAN-Phosphotyrosine500 def: "Protein FNBP1_HUMAN with the residue 500 substituted with Phosphotyrosine" [UniProtKB:Q96RU3] comment: By similarity xref: UniProtKB:Q96RU3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005386 ! FNBP1_HUMAN [Term] id: CCO:B0031320 name: FXR1_HUMAN-Phosphotyrosine68 def: "Protein FXR1_HUMAN with the residue 68 substituted with Phosphotyrosine" [UniProtKB:P51114] comment: By similarity xref: UniProtKB:P51114 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006140 ! FXR1_HUMAN [Term] id: CCO:B0031321 name: FYN_HUMAN-Phosphotyrosine185 def: "Protein FYN_HUMAN with the residue 185 substituted with Phosphotyrosine" [UniProtKB:P06241] comment: By similarity xref: UniProtKB:P06241 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005609 ! FYN_HUMAN [Term] id: CCO:B0031322 name: G3P_HUMAN-Phosphotyrosine314 def: "Protein G3P_HUMAN with the residue 314 substituted with Phosphotyrosine" [UniProtKB:P04406] comment: By similarity xref: UniProtKB:P04406 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005458 ! G3P_HUMAN [Term] id: CCO:B0031323 name: G3P_HUMAN-Phosphotyrosine320 def: "Protein G3P_HUMAN with the residue 320 substituted with Phosphotyrosine" [UniProtKB:P04406] comment: By similarity xref: UniProtKB:P04406 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005458 ! G3P_HUMAN [Term] id: CCO:B0031324 name: GAB2_HUMAN-Phosphoserine264 def: "Protein GAB2_HUMAN with the residue 264 substituted with Phosphoserine" [UniProtKB:Q9UQC2] comment: By similarity xref: UniProtKB:Q9UQC2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005924 ! GAB2_HUMAN [Term] id: CCO:B0031325 name: GAB2_HUMAN-Phosphothreonine265 def: "Protein GAB2_HUMAN with the residue 265 substituted with Phosphothreonine" [UniProtKB:Q9UQC2] comment: By similarity xref: UniProtKB:Q9UQC2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005924 ! GAB2_HUMAN [Term] id: CCO:B0031326 name: GAB2_HUMAN-Phosphotyrosine293 def: "Protein GAB2_HUMAN with the residue 293 substituted with Phosphotyrosine" [UniProtKB:Q9UQC2] comment: By similarity xref: UniProtKB:Q9UQC2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005924 ! GAB2_HUMAN [Term] id: CCO:B0031327 name: GIT1_HUMAN-Phosphotyrosine224 def: "Protein GIT1_HUMAN with the residue 224 substituted with Phosphotyrosine" [UniProtKB:Q9Y2X7] comment: By similarity xref: UniProtKB:Q9Y2X7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:B0031328 name: GRLF1_HUMAN-Phosphotyrosine1087 def: "Protein GRLF1_HUMAN with the residue 1087 substituted with Phosphotyrosine" [UniProtKB:Q9NRY4] comment: By similarity xref: UniProtKB:Q9NRY4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002160 ! GRLF1_HUMAN [Term] id: CCO:B0031331 name: HS90A_HUMAN-Phosphotyrosine313 def: "Protein HS90A_HUMAN with the residue 313 substituted with Phosphotyrosine" [UniProtKB:P07900] comment: By similarity xref: UniProtKB:P07900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005698 ! HS90A_HUMAN [Term] id: CCO:B0031332 name: HS90A_HUMAN-Phosphotyrosine492 def: "Protein HS90A_HUMAN with the residue 492 substituted with Phosphotyrosine" [UniProtKB:P07900] comment: By similarity xref: UniProtKB:P07900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005698 ! HS90A_HUMAN [Term] id: CCO:B0031333 name: HS90B_HUMAN-Phosphotyrosine305 def: "Protein HS90B_HUMAN with the residue 305 substituted with Phosphotyrosine" [UniProtKB:P08238] comment: By similarity xref: UniProtKB:P08238 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005580 ! HS90B_HUMAN [Term] id: CCO:B0031334 name: HSP7C_HUMAN-Phosphotyrosine41 def: "Protein HSP7C_HUMAN with the residue 41 substituted with Phosphotyrosine" [UniProtKB:P11142] comment: By similarity xref: UniProtKB:P11142 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005699 ! HSP7C_HUMAN [Term] id: CCO:B0031335 name: LIS1_HUMAN-Phosphotyrosine28 def: "Protein LIS1_HUMAN with the residue 28 substituted with Phosphotyrosine" [UniProtKB:P43034] comment: By similarity xref: UniProtKB:P43034 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001618 ! LIS1_HUMAN [Term] id: CCO:B0031336 name: LYN_HUMAN-Phosphotyrosine193 def: "Protein LYN_HUMAN with the residue 193 substituted with Phosphotyrosine" [UniProtKB:P07948] comment: By similarity xref: UniProtKB:P07948 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005457 ! LYN_HUMAN [Term] id: CCO:B0031337 name: LYN_HUMAN-Phosphotyrosine194 def: "Protein LYN_HUMAN with the residue 194 substituted with Phosphotyrosine" [UniProtKB:P07948] comment: By similarity xref: UniProtKB:P07948 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005457 ! LYN_HUMAN [Term] id: CCO:B0031338 name: M2OM_HUMAN-Phosphotyrosine102 def: "Protein M2OM_HUMAN with the residue 102 substituted with Phosphotyrosine" [UniProtKB:Q02978] comment: By similarity xref: UniProtKB:Q02978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006316 ! M2OM_HUMAN [Term] id: CCO:B0031339 name: M2OM_HUMAN-Phosphotyrosine202 def: "Protein M2OM_HUMAN with the residue 202 substituted with Phosphotyrosine" [UniProtKB:Q02978] comment: By similarity xref: UniProtKB:Q02978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006316 ! M2OM_HUMAN [Term] id: CCO:B0031341 name: MTSS1_HUMAN-Phosphotyrosine526 def: "Protein MTSS1_HUMAN with the residue 526 substituted with Phosphotyrosine" [UniProtKB:O43312] comment: By similarity xref: UniProtKB:O43312 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001390 ! MTSS1_HUMAN [Term] id: CCO:B0031342 name: MYO16_HUMAN-Phosphotyrosine1432 def: "Protein MYO16_HUMAN with the residue 1432 substituted with Phosphotyrosine" [UniProtKB:Q9Y6X6] comment: By similarity xref: UniProtKB:Q9Y6X6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000321 ! motor activity relationship: has_function CCO:F0000323 ! actin binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0008035 ! actin filament binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000788 ! myosin complex relationship: located_in CCO:C0001996 ! perinuclear region of cytoplasm relationship: transformation_of CCO:B0002267 ! MYO16_HUMAN [Term] id: CCO:B0031343 name: NDC80_HUMAN-Phosphoserine55 def: "Protein NDC80_HUMAN with the residue 55 substituted with Phosphoserine" [UniProtKB:O14777] xref: UniProtKB:O14777 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001360 ! NDC80_HUMAN [Term] id: CCO:B0031344 name: NDC80_HUMAN-Phosphoserine62 def: "Protein NDC80_HUMAN with the residue 62 substituted with Phosphoserine" [UniProtKB:O14777] xref: UniProtKB:O14777 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001360 ! NDC80_HUMAN [Term] id: CCO:B0031345 name: NDC80_HUMAN-Phosphoserine76 def: "Protein NDC80_HUMAN with the residue 76 substituted with Phosphoserine" [UniProtKB:O14777] xref: UniProtKB:O14777 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001360 ! NDC80_HUMAN [Term] id: CCO:B0031346 name: NDC80_HUMAN-Phosphoserine77 def: "Protein NDC80_HUMAN with the residue 77 substituted with Phosphoserine" [UniProtKB:O14777] xref: UniProtKB:O14777 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001360 ! NDC80_HUMAN [Term] id: CCO:B0031347 name: NDC80_HUMAN-Phosphoserine165 def: "Protein NDC80_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:O14777] comment: by NEK2; xref: UniProtKB:O14777 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: located_in CCO:C0000252 ! nucleus relationship: transformation_of CCO:B0001360 ! NDC80_HUMAN [Term] id: CCO:B0031348 name: NEK2_HUMAN-Phosphothreonine170 def: "Protein NEK2_HUMAN with the residue 170 substituted with Phosphothreonine" [UniProtKB:P51955] comment: by autocatalysis; Probable xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031349 name: NEK2_HUMAN-Phosphoserine171 def: "Protein NEK2_HUMAN with the residue 171 substituted with Phosphoserine" [UniProtKB:P51955] comment: by autocatalysis; Probable xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031350 name: NEK2_HUMAN-Phosphothreonine179 def: "Protein NEK2_HUMAN with the residue 179 substituted with Phosphothreonine" [UniProtKB:P51955] comment: by autocatalysis; xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031351 name: NEK2_HUMAN-Phosphoserine241 def: "Protein NEK2_HUMAN with the residue 241 substituted with Phosphoserine" [UniProtKB:P51955] comment: by autocatalysis; xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031352 name: NEK2_HUMAN-Phosphoserine356 def: "Protein NEK2_HUMAN with the residue 356 substituted with Phosphoserine" [UniProtKB:P51955] xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031353 name: NEK2_HUMAN-Phosphoserine387 def: "Protein NEK2_HUMAN with the residue 387 substituted with Phosphoserine" [UniProtKB:P51955] xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031354 name: NEK2_HUMAN-Phosphoserine390 def: "Protein NEK2_HUMAN with the residue 390 substituted with Phosphoserine" [UniProtKB:P51955] xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031355 name: NEK2_HUMAN-Phosphoserine397 def: "Protein NEK2_HUMAN with the residue 397 substituted with Phosphoserine" [UniProtKB:P51955] xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031356 name: NEK2_HUMAN-Phosphoserine402 def: "Protein NEK2_HUMAN with the residue 402 substituted with Phosphoserine" [UniProtKB:P51955] xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031357 name: NEK2_HUMAN-Phosphoserine428 def: "Protein NEK2_HUMAN with the residue 428 substituted with Phosphoserine" [UniProtKB:P51955] xref: UniProtKB:P51955 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:B0031358 name: NFL_HUMAN-Phosphotyrosine43 def: "Protein NFL_HUMAN with the residue 43 substituted with Phosphotyrosine" [UniProtKB:P07196] comment: By similarity xref: UniProtKB:P07196 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006343 ! NFL_HUMAN [Term] id: CCO:B0031359 name: NFL_HUMAN-Phosphotyrosine424 def: "Protein NFL_HUMAN with the residue 424 substituted with Phosphotyrosine" [UniProtKB:P07196] comment: By similarity xref: UniProtKB:P07196 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006343 ! NFL_HUMAN [Term] id: CCO:B0031360 name: NFL_HUMAN-Phosphotyrosine432 def: "Protein NFL_HUMAN with the residue 432 substituted with Phosphotyrosine" [UniProtKB:P07196] comment: By similarity xref: UniProtKB:P07196 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006343 ! NFL_HUMAN [Term] id: CCO:B0031361 name: NUCL_HUMAN-Phosphoserine206 def: "Protein NUCL_HUMAN with the residue 206 substituted with Phosphoserine" [UniProtKB:P19338] xref: UniProtKB:P19338 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:B0031362 name: PABP1_HUMAN-Phosphotyrosine116 def: "Protein PABP1_HUMAN with the residue 116 substituted with Phosphotyrosine" [UniProtKB:P11940] comment: By similarity xref: UniProtKB:P11940 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005854 ! PABP1_HUMAN [Term] id: CCO:B0031363 name: PHB_HUMAN-Phosphotyrosine249 def: "Protein PHB_HUMAN with the residue 249 substituted with Phosphotyrosine" [UniProtKB:P35232] comment: By similarity xref: UniProtKB:P35232 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001591 ! PHB_HUMAN [Term] id: CCO:B0031364 name: PLCG1_HUMAN-Phosphotyrosine379 def: "Protein PLCG1_HUMAN with the residue 379 substituted with Phosphotyrosine" [UniProtKB:P19174] comment: By similarity xref: UniProtKB:P19174 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005610 ! PLCG1_HUMAN [Term] id: CCO:B0031365 name: PLCG1_HUMAN-Phosphotyrosine481 def: "Protein PLCG1_HUMAN with the residue 481 substituted with Phosphotyrosine" [UniProtKB:P19174] comment: By similarity xref: UniProtKB:P19174 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005610 ! PLCG1_HUMAN [Term] id: CCO:B0031366 name: PLCG1_HUMAN-Phosphotyrosine506 def: "Protein PLCG1_HUMAN with the residue 506 substituted with Phosphotyrosine" [UniProtKB:P19174] comment: By similarity xref: UniProtKB:P19174 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005610 ! PLCG1_HUMAN [Term] id: CCO:B0031367 name: PLCG1_HUMAN-Phosphotyrosine977 def: "Protein PLCG1_HUMAN with the residue 977 substituted with Phosphotyrosine" [UniProtKB:P19174] comment: By similarity xref: UniProtKB:P19174 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005610 ! PLCG1_HUMAN [Term] id: CCO:B0031368 name: PROF2_HUMAN-Phosphotyrosine99 def: "Protein PROF2_HUMAN with the residue 99 substituted with Phosphotyrosine" [UniProtKB:P35080] comment: By similarity xref: UniProtKB:P35080 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006155 ! PROF2_HUMAN [Term] id: CCO:B0031369 name: PTN6_HUMAN-Phosphotyrosine377 def: "Protein PTN6_HUMAN with the residue 377 substituted with Phosphotyrosine" [UniProtKB:P29350] comment: By similarity xref: UniProtKB:P29350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005608 ! PTN6_HUMAN [Term] id: CCO:B0031370 name: PTN6_HUMAN-Phosphotyrosine536 def: "Protein PTN6_HUMAN with the residue 536 substituted with Phosphotyrosine" [UniProtKB:P29350] comment: By similarity xref: UniProtKB:P29350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005608 ! PTN6_HUMAN [Term] id: CCO:B0031371 name: RHOB_HUMAN-Phosphotyrosine154 def: "Protein RHOB_HUMAN with the residue 154 substituted with Phosphotyrosine" [UniProtKB:P62745] comment: By similarity xref: UniProtKB:P62745 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001692 ! RHOB_HUMAN [Term] id: CCO:B0031372 name: RS24_HUMAN-Phosphotyrosine81 def: "Protein RS24_HUMAN with the residue 81 substituted with Phosphotyrosine" [UniProtKB:P62847] comment: By similarity xref: UniProtKB:P62847 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005726 ! RS24_HUMAN [Term] id: CCO:B0031373 name: SEPT7_HUMAN-Phosphotyrosine30 def: "Protein SEPT7_HUMAN with the residue 30 substituted with Phosphotyrosine" [UniProtKB:Q16181] comment: By similarity xref: UniProtKB:Q16181 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001816 ! SEPT7_HUMAN [Term] id: CCO:B0031374 name: SET_HUMAN-Phosphotyrosine146 def: "Protein SET_HUMAN with the residue 146 substituted with Phosphotyrosine" [UniProtKB:Q01105] comment: By similarity xref: UniProtKB:Q01105 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005519 ! SET_HUMAN [Term] id: CCO:B0031375 name: SPTB2_HUMAN-Phosphotyrosine1805 def: "Protein SPTB2_HUMAN with the residue 1805 substituted with Phosphotyrosine" [UniProtKB:Q01082] comment: By similarity xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0031376 name: SRC_HUMAN-Phosphotyrosine187 def: "Protein SRC_HUMAN with the residue 187 substituted with Phosphotyrosine" [UniProtKB:P12931] comment: By similarity xref: UniProtKB:P12931 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005464 ! SRC_HUMAN [Term] id: CCO:B0031377 name: TBA4A_HUMAN-Phosphotyrosine319 def: "Protein TBA4A_HUMAN with the residue 319 substituted with Phosphotyrosine" [UniProtKB:P68366] comment: By similarity xref: UniProtKB:P68366 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005449 ! TBA4A_HUMAN [Term] id: CCO:B0031379 name: TBB4_HUMAN-Phosphotyrosine36 def: "Protein TBB4_HUMAN with the residue 36 substituted with Phosphotyrosine" [UniProtKB:P04350] comment: By similarity xref: UniProtKB:P04350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006167 ! TBB4_HUMAN [Term] id: CCO:B0031380 name: TBB5_HUMAN-Phosphotyrosine340 def: "Protein TBB5_HUMAN with the residue 340 substituted with Phosphotyrosine" [UniProtKB:P07437] comment: By similarity xref: UniProtKB:P07437 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005727 ! TBB5_HUMAN [Term] id: CCO:B0031381 name: VDAC1_HUMAN-Phosphotyrosine67 def: "Protein VDAC1_HUMAN with the residue 67 substituted with Phosphotyrosine" [UniProtKB:P21796] comment: By similarity xref: UniProtKB:P21796 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005765 ! VDAC1_HUMAN [Term] id: CCO:B0031382 name: VDAC2_HUMAN-Phosphotyrosine206 def: "Protein VDAC2_HUMAN with the residue 206 substituted with Phosphotyrosine" [UniProtKB:P45880] comment: By similarity xref: UniProtKB:P45880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005777 ! VDAC2_HUMAN [Term] id: CCO:B0031383 name: VDAC3_HUMAN-Phosphotyrosine48 def: "Protein VDAC3_HUMAN with the residue 48 substituted with Phosphotyrosine" [UniProtKB:Q9Y277] comment: By similarity xref: UniProtKB:Q9Y277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005738 ! VDAC3_HUMAN [Term] id: CCO:B0031384 name: VIME_HUMAN-Phosphotyrosine53 def: "Protein VIME_HUMAN with the residue 53 substituted with Phosphotyrosine" [UniProtKB:P08670] comment: By similarity xref: UniProtKB:P08670 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:B0031385 name: YBOX1_HUMAN-Phosphoserine167 def: "Protein YBOX1_HUMAN with the residue 167 substituted with Phosphoserine" [UniProtKB:P67809] xref: UniProtKB:P67809 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005742 ! YBOX1_HUMAN [Term] id: CCO:B0031386 name: YES_HUMAN-Phosphotyrosine194 def: "Protein YES_HUMAN with the residue 194 substituted with Phosphotyrosine" [UniProtKB:P07947] comment: By similarity xref: UniProtKB:P07947 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005465 ! YES_HUMAN [Term] id: CCO:B0031387 name: YES_HUMAN-Phosphotyrosine222 def: "Protein YES_HUMAN with the residue 222 substituted with Phosphotyrosine" [UniProtKB:P07947] comment: By similarity xref: UniProtKB:P07947 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005465 ! YES_HUMAN [Term] id: CCO:B0032571 name: HOP2_HUMAN def: "Homologous-pairing protein 2 homolog" [UniProtKB:Q9P2W1] synonym: "Nuclear receptor coactivator GT198" EXACT [UniProtKB:Q9P2W1] synonym: "Proteasome 26S ATPase subunit 3-interacting protein" EXACT [UniProtKB:Q9P2W1] synonym: "PSMC3-interacting protein" EXACT [UniProtKB:Q9P2W1] synonym: "Tat-binding protein 1-interacting protein" EXACT [UniProtKB:Q9P2W1] synonym: "TBP-1-interacting protein" EXACT [UniProtKB:Q9P2W1] xref: EMBL:AAC41915.1 xref: EMBL:AAH08792.1 xref: EMBL:AAL33609.1 xref: EMBL:BAA92872.1 xref: UniProtKB:Q14458 xref: UniProtKB:Q8WXG2 xref: UniProtKB:Q96HA2 xref: UniProtKB:Q9P2W1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006425 ! PSMC3IP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0032849 ! HOP2_HUMAN-Phosphoserine29 [Term] id: CCO:B0032651 name: PSMD6_HUMAN def: "26S proteasome non-ATPase regulatory subunit 6" [UniProtKB:Q15008] synonym: "26S proteasome regulatory subunit S10" EXACT [UniProtKB:Q15008] synonym: "Breast cancer-associated protein SGA-113M" EXACT [UniProtKB:Q15008] synonym: "p42A" EXACT [UniProtKB:Q15008] synonym: "Phosphonoformate immuno-associated protein 4" EXACT [UniProtKB:Q15008] synonym: "Proteasome regulatory particle subunit p44S10" EXACT [UniProtKB:Q15008] xref: EMBL:AAF65540.1 xref: EMBL:AAH00630.1 xref: EMBL:AAH00904.1 xref: EMBL:AAH12369.1 xref: EMBL:AAQ09946.1 xref: EMBL:AAS68366.1 xref: EMBL:BAA03497.1 xref: UniProtKB:Q15008 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008034 ! PSMD6_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003445 ! ATPase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: participates_in CCO:I0008712 ! traf6-psmd6 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0032819 name: ASNS_HUMAN def: "Asparagine synthetase [glutamine-hydrolyzing]" [UniProtKB:P08243] synonym: "Cell cycle control protein TS11" EXACT [UniProtKB:P08243] synonym: "EC 6.3.5.4" EXACT [UniProtKB:P08243] synonym: "Glutamine-dependent asparagine synthetase" EXACT [UniProtKB:P08243] xref: EMBL:AAA36781.1 xref: EMBL:AAA51789.1 xref: EMBL:AAA52756.1 xref: EMBL:AAA63266.1 xref: EMBL:AAH08723.1 xref: EMBL:AAH14621.1 xref: EMBL:AAP35777.1 xref: EMBL:AAQ96856.1 xref: UniProtKB:P08184 xref: UniProtKB:P08243 xref: UniProtKB:Q15666 xref: UniProtKB:Q549T9 xref: UniProtKB:Q96HD0 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006423 ! ASNS_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008552 ! strn4-asns physical interaction relationship: participates_in CCO:P0000259 ! positive regulation of mitotic cell cycle [Term] id: CCO:B0032820 name: ZN318_HUMAN def: "Zinc finger protein 318" [UniProtKB:Q5VUA4] synonym: "Endocrine regulatory protein" EXACT [UniProtKB:Q5VUA4] xref: EMBL:AAD17298.1 xref: EMBL:AAD47387.1 xref: EMBL:AAH30687.2 xref: EMBL:AAH98434.1 xref: EMBL:BAA34799.1 xref: EMBL:CAH71374.2 xref: EMBL:CAI14459.2 xref: UniProtKB:O94796 xref: UniProtKB:Q4G0E4 xref: UniProtKB:Q5VUA4 xref: UniProtKB:Q8NEM6 xref: UniProtKB:Q9UNU8 xref: UniProtKB:Q9Y2W9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006429 ! ZNF318_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis relationship: transforms_into CCO:B0032863 ! ZN318_HUMAN-Phosphoserine305 relationship: transforms_into CCO:B0032864 ! ZN318_HUMAN-Phosphoserine307 relationship: transforms_into CCO:B0032865 ! ZN318_HUMAN-Phosphoserine464 relationship: transforms_into CCO:B0032866 ! ZN318_HUMAN-Phosphoserine550 relationship: transforms_into CCO:B0032867 ! ZN318_HUMAN-Phosphoserine1243 relationship: transforms_into CCO:B0032868 ! ZN318_HUMAN-Phosphoserine1623 relationship: transforms_into CCO:B0032869 ! ZN318_HUMAN-Phosphoserine1713 relationship: transforms_into CCO:B0032870 ! ZN318_HUMAN-Phosphoserine2101 [Term] id: CCO:B0032821 name: ZWILC_HUMAN def: "Protein zwilch homolog" [UniProtKB:Q9H900] synonym: "hZwilch" EXACT [UniProtKB:Q9H900] xref: EMBL:AAH36900.1 xref: EMBL:AAH90041.1 xref: EMBL:BAA91414.1 xref: EMBL:BAB14446.1 xref: EMBL:BAB55133.1 xref: EMBL:CAE45821.1 xref: EMBL:EAW77779.1 xref: UniProtKB:Q6N049 xref: UniProtKB:Q8N404 xref: UniProtKB:Q96SY7 xref: UniProtKB:Q9H900 xref: UniProtKB:Q9NWG7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006023 ! ZWILCH_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint [Term] id: CCO:B0032832 name: FOX1_HUMAN def: "Fox-1 homolog" [UniProtKB:Q9NWB1] synonym: "Ataxin-2-binding protein 1" EXACT [UniProtKB:Q9NWB1] synonym: "Hexaribonucleotide-binding protein 1" EXACT [UniProtKB:Q9NWB1] xref: EMBL:AAF78291.1 xref: EMBL:AAI13692.1 xref: EMBL:AAL71904.1 xref: EMBL:AAL83405.1 xref: EMBL:AAL83406.1 xref: EMBL:AAL83407.1 xref: EMBL:AAL83408.1 xref: EMBL:AAL83409.1 xref: EMBL:AAP41925.1 xref: EMBL:BAA91472.1 xref: UniProtKB:Q7Z7I7 xref: UniProtKB:Q8TAE3 xref: UniProtKB:Q8TAF2 xref: UniProtKB:Q8WYB2 xref: UniProtKB:Q9NS20 xref: UniProtKB:Q9NWB1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006424 ! FOX1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006644 ! lzts2-a2bp1 physical interaction relationship: participates_in CCO:I0008701 ! a2bp1-psmf1 physical interaction relationship: participates_in CCO:I0008766 ! psmf1-a2bp1 physical interaction [Term] id: CCO:B0032833 name: GDIR1_HUMAN def: "Rho GDP-dissociation inhibitor 1" [UniProtKB:P52565] synonym: "Rho GDI 1" EXACT [UniProtKB:P52565] synonym: "Rho-GDI alpha" EXACT [UniProtKB:P52565] xref: EMBL:AAA36566.1 xref: EMBL:AAH05851.1 xref: EMBL:AAH05875.1 xref: EMBL:AAH08701.1 xref: EMBL:AAH09759.1 xref: EMBL:AAH16031.1 xref: EMBL:AAH16185.1 xref: EMBL:AAH24258.1 xref: EMBL:AAH27730.1 xref: EMBL:AAH75827.1 xref: EMBL:AAM21074.1 xref: EMBL:AAP35530.1 xref: EMBL:BAA03096.1 xref: EMBL:CAA45344.1 xref: EMBL:CAA49281.1 xref: UniProtKB:P52565 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004692 ! ARHGDIA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008356 ! arhgdia-cdkn1b physical interaction relationship: transforms_into CCO:B0032847 ! GDIR1_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0032848 ! GDIR1_HUMAN-N6-acetyllysine141 [Term] id: CCO:B0032839 name: DBF4A_HUMAN-Phosphoserine381 def: "Protein DBF4A_HUMAN with the residue 381 substituted with Phosphoserine" [UniProtKB:Q9UBU7] xref: UniProtKB:Q9UBU7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002194 ! DBF4A_HUMAN [Term] id: CCO:B0032840 name: DBF4A_HUMAN-Phosphothreonine535 def: "Protein DBF4A_HUMAN with the residue 535 substituted with Phosphothreonine" [UniProtKB:Q9UBU7] xref: UniProtKB:Q9UBU7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002194 ! DBF4A_HUMAN [Term] id: CCO:B0032841 name: DBF4A_HUMAN-Phosphoserine539 def: "Protein DBF4A_HUMAN with the residue 539 substituted with Phosphoserine" [UniProtKB:Q9UBU7] xref: UniProtKB:Q9UBU7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002194 ! DBF4A_HUMAN [Term] id: CCO:B0032842 name: DYHC1_HUMAN-Phosphoserine2410 def: "Protein DYHC1_HUMAN with the residue 2410 substituted with Phosphoserine" [UniProtKB:Q14204] xref: UniProtKB:Q14204 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001780 ! DYHC1_HUMAN [Term] id: CCO:B0032843 name: DYHC1_HUMAN-Phosphotyrosine3379 def: "Protein DYHC1_HUMAN with the residue 3379 substituted with Phosphotyrosine" [UniProtKB:Q14204] comment: By similarity xref: UniProtKB:Q14204 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001780 ! DYHC1_HUMAN [Term] id: CCO:B0032844 name: DYHC1_HUMAN-Phosphothreonine4218 def: "Protein DYHC1_HUMAN with the residue 4218 substituted with Phosphothreonine" [UniProtKB:Q14204] comment: By similarity xref: UniProtKB:Q14204 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001780 ! DYHC1_HUMAN [Term] id: CCO:B0032845 name: DYHC1_HUMAN-Phosphothreonine4221 def: "Protein DYHC1_HUMAN with the residue 4221 substituted with Phosphothreonine" [UniProtKB:Q14204] comment: By similarity xref: UniProtKB:Q14204 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001780 ! DYHC1_HUMAN [Term] id: CCO:B0032846 name: DYHC1_HUMAN-Phosphoserine4368 def: "Protein DYHC1_HUMAN with the residue 4368 substituted with Phosphoserine" [UniProtKB:Q14204] xref: UniProtKB:Q14204 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001780 ! DYHC1_HUMAN [Term] id: CCO:B0032847 name: GDIR1_HUMAN-N-acetylalanine2 def: "Protein GDIR1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P52565] xref: UniProtKB:P52565 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032833 ! GDIR1_HUMAN [Term] id: CCO:B0032848 name: GDIR1_HUMAN-N6-acetyllysine141 def: "Protein GDIR1_HUMAN with the residue 141 substituted with N6-acetyllysine" [UniProtKB:P52565] xref: UniProtKB:P52565 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032833 ! GDIR1_HUMAN [Term] id: CCO:B0032849 name: HOP2_HUMAN-Phosphoserine29 def: "Protein HOP2_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:Q9P2W1] xref: UniProtKB:Q9P2W1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032571 ! HOP2_HUMAN [Term] id: CCO:B0032850 name: MCM2_HUMAN-Phosphoserine53 def: "Protein MCM2_HUMAN with the residue 53 substituted with Phosphoserine" [UniProtKB:P49736] comment: by CDC7; xref: UniProtKB:P49736 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:B0032851 name: MYH10_HUMAN-Phosphoserine1013 def: "Protein MYH10_HUMAN with the residue 1013 substituted with Phosphoserine" [UniProtKB:P35580] xref: UniProtKB:P35580 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:B0032852 name: MYH10_HUMAN-Phosphoserine1938 def: "Protein MYH10_HUMAN with the residue 1938 substituted with Phosphoserine" [UniProtKB:P35580] comment: By similarity xref: UniProtKB:P35580 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:B0032853 name: MYH10_HUMAN-Phosphoserine1952 def: "Protein MYH10_HUMAN with the residue 1952 substituted with Phosphoserine" [UniProtKB:P35580] comment: By similarity xref: UniProtKB:P35580 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:B0032854 name: MYH10_HUMAN-Phosphoserine1956 def: "Protein MYH10_HUMAN with the residue 1956 substituted with Phosphoserine" [UniProtKB:P35580] comment: By similarity xref: UniProtKB:P35580 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:B0032855 name: MYH10_HUMAN-Phosphothreonine1960 def: "Protein MYH10_HUMAN with the residue 1960 substituted with Phosphothreonine" [UniProtKB:P35580] xref: UniProtKB:P35580 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:B0032856 name: P53_HUMAN-N6-methyllysine370 def: "Protein P53_HUMAN with the residue 370 substituted with N6-methyllysine" [UniProtKB:P04637] xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0032857 name: P53_HUMAN-N6-methyllysine372 def: "Protein P53_HUMAN with the residue 372 substituted with N6-methyllysine" [UniProtKB:P04637] xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0032858 name: TAF10_HUMAN-N6-methyllysine189 def: "Protein TAF10_HUMAN with the residue 189 substituted with N6-methyllysine" [UniProtKB:Q12962] xref: UniProtKB:Q12962 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005937 ! TAF10_HUMAN [Term] id: CCO:B0032859 name: TP53B_HUMAN-Phosphoserine166 def: "Protein TP53B_HUMAN with the residue 166 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0032860 name: TP53B_HUMAN-Phosphoserine176 def: "Protein TP53B_HUMAN with the residue 176 substituted with Phosphoserine" [UniProtKB:Q12888] comment: Probable xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0032861 name: TP53B_HUMAN-Phosphoserine178 def: "Protein TP53B_HUMAN with the residue 178 substituted with Phosphoserine" [UniProtKB:Q12888] comment: Probable xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0032862 name: TP53B_HUMAN-Phosphoserine452 def: "Protein TP53B_HUMAN with the residue 452 substituted with Phosphoserine" [UniProtKB:Q12888] xref: UniProtKB:Q12888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:B0032863 name: ZN318_HUMAN-Phosphoserine305 def: "Protein ZN318_HUMAN with the residue 305 substituted with Phosphoserine" [UniProtKB:Q5VUA4] xref: UniProtKB:Q5VUA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032820 ! ZN318_HUMAN [Term] id: CCO:B0032864 name: ZN318_HUMAN-Phosphoserine307 def: "Protein ZN318_HUMAN with the residue 307 substituted with Phosphoserine" [UniProtKB:Q5VUA4] xref: UniProtKB:Q5VUA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032820 ! ZN318_HUMAN [Term] id: CCO:B0032865 name: ZN318_HUMAN-Phosphoserine464 def: "Protein ZN318_HUMAN with the residue 464 substituted with Phosphoserine" [UniProtKB:Q5VUA4] xref: UniProtKB:Q5VUA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032820 ! ZN318_HUMAN [Term] id: CCO:B0032866 name: ZN318_HUMAN-Phosphoserine550 def: "Protein ZN318_HUMAN with the residue 550 substituted with Phosphoserine" [UniProtKB:Q5VUA4] comment: By similarity xref: UniProtKB:Q5VUA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032820 ! ZN318_HUMAN [Term] id: CCO:B0032867 name: ZN318_HUMAN-Phosphoserine1243 def: "Protein ZN318_HUMAN with the residue 1243 substituted with Phosphoserine" [UniProtKB:Q5VUA4] xref: UniProtKB:Q5VUA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032820 ! ZN318_HUMAN [Term] id: CCO:B0032868 name: ZN318_HUMAN-Phosphoserine1623 def: "Protein ZN318_HUMAN with the residue 1623 substituted with Phosphoserine" [UniProtKB:Q5VUA4] xref: UniProtKB:Q5VUA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032820 ! ZN318_HUMAN [Term] id: CCO:B0032869 name: ZN318_HUMAN-Phosphoserine1713 def: "Protein ZN318_HUMAN with the residue 1713 substituted with Phosphoserine" [UniProtKB:Q5VUA4] xref: UniProtKB:Q5VUA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032820 ! ZN318_HUMAN [Term] id: CCO:B0032870 name: ZN318_HUMAN-Phosphoserine2101 def: "Protein ZN318_HUMAN with the residue 2101 substituted with Phosphoserine" [UniProtKB:Q5VUA4] xref: UniProtKB:Q5VUA4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0032820 ! ZN318_HUMAN [Term] id: CCO:B0032873 name: MND1_HUMAN def: "Meiotic nuclear division protein 1 homolog" [UniProtKB:Q9BWT6] xref: EMBL:AAH32142.1 xref: EMBL:AAK26168.1 xref: EMBL:EAX04964.1 xref: EMBL:EAX04965.1 xref: UniProtKB:Q9BWT6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0007828 ! MND1_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0033478 name: DBF4B_HUMAN def: "Protein DBF4 homolog B" [UniProtKB:Q8NFT6] synonym: "Activator of S phase kinase-like protein 1" EXACT [UniProtKB:Q8NFT6] synonym: "ASK-like protein 1" EXACT [UniProtKB:Q8NFT6] synonym: "Chiffon homolog B" EXACT [UniProtKB:Q8NFT6] synonym: "Dbf4-related factor 1" EXACT [UniProtKB:Q8NFT6] xref: EMBL:AAH16158.1 xref: EMBL:AAL75985.1 xref: EMBL:AAM73808.1 xref: EMBL:BAB14431.1 xref: EMBL:EAW51581.1 xref: EMBL:EAW51584.1 xref: EMBL:EAW51587.1 xref: UniProtKB:Q8NFT6 xref: UniProtKB:Q8TEX0 xref: UniProtKB:Q96B19 xref: UniProtKB:Q9H912 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0007444 ! DBF4B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0033797 name: Q548C9_HUMAN def: "Septin 6" [UniProtKB:Q548C9] synonym: "cDNA FLJ77872, highly similar to Homo sapiens SEPTIN6 type V (SEPTIN6) mRNA" EXACT [UniProtKB:Q548C9] synonym: "Septin 6, isoform CRA_e" EXACT [UniProtKB:Q548C9] xref: EMBL:AAN76547.1 xref: EMBL:BAF83666.1 xref: EMBL:CAI41425.1 xref: EMBL:EAW89855.1 xref: UniProtKB:Q548C9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005589 ! SEPT6_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0033798 name: Q541S4_HUMAN def: "Septin 6" [UniProtKB:Q541S4] synonym: "Septin 6, isoform CRA_d" EXACT [UniProtKB:Q541S4] xref: EMBL:AAF97496.1 xref: EMBL:AAK61492.1 xref: EMBL:CAI41428.1 xref: EMBL:EAW89854.1 xref: UniProtKB:Q541S4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005589 ! SEPT6_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0034007 name: PSB7_HUMAN def: "Proteasome subunit beta type-7 precursor" [UniProtKB:Q99436] synonym: "EC 3.4.25.1" EXACT [UniProtKB:Q99436] synonym: "Macropain chain Z" EXACT [UniProtKB:Q99436] synonym: "Multicatalytic endopeptidase complex chain Z" EXACT [UniProtKB:Q99436] synonym: "Proteasome subunit Z" EXACT [UniProtKB:Q99436] xref: EMBL:AAH00509.1 xref: EMBL:AAH17116.2 xref: EMBL:BAA07238.1 xref: UniProtKB:Q96AG8 xref: UniProtKB:Q99436 xref: UniProtKB:Q9BWA7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008024 ! PSMB7_human relationship: has_function CCO:F0000644 ! endopeptidase activity relationship: has_function CCO:F0000721 ! threonine endopeptidase activity relationship: has_function CCO:F0001783 ! peptidase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: located_in CCO:C0002080 ! proteasome core complex relationship: participates_in CCO:I0008742 ! beta1-beta7 physical interaction relationship: participates_in CCO:I0008745 ! beta1i-beta7 physical interaction relationship: participates_in CCO:I0008754 ! beta5-beta7 physical interaction relationship: participates_in CCO:I0008755 ! beta5i-beta7 physical interaction relationship: participates_in CCO:I0008756 ! beta6-beta7 physical interaction relationship: participates_in CCO:I0008757 ! beta7-beta3 physical interaction relationship: participates_in CCO:I0008758 ! beta7-beta7 physical interaction relationship: participates_in CCO:I0008759 ! beta7-beta5i physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:I0008818 ! c2f-psmb7 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0035481 ! PSB7_HUMAN-Phosphotyrosine154 [Term] id: CCO:B0035233 name: MYH9_HUMAN-N-acetylalanine2 def: "Protein MYH9_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P35579] xref: UniProtKB:P35579 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019193 ! MYH9_HUMAN [Term] id: CCO:B0035234 name: MYH9_HUMAN-Phosphothreonine181 def: "Protein MYH9_HUMAN with the residue 181 substituted with Phosphothreonine" [UniProtKB:P35579] comment: By similarity xref: UniProtKB:P35579 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019193 ! MYH9_HUMAN [Term] id: CCO:B0035235 name: MYH9_HUMAN-Phosphothreonine638 def: "Protein MYH9_HUMAN with the residue 638 substituted with Phosphothreonine" [UniProtKB:P35579] comment: By similarity xref: UniProtKB:P35579 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019193 ! MYH9_HUMAN [Term] id: CCO:B0035236 name: MYH9_HUMAN-Phosphotyrosine754 def: "Protein MYH9_HUMAN with the residue 754 substituted with Phosphotyrosine" [UniProtKB:P35579] comment: By similarity xref: UniProtKB:P35579 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019193 ! MYH9_HUMAN [Term] id: CCO:B0035237 name: MYH9_HUMAN-Phosphoserine1943 def: "Protein MYH9_HUMAN with the residue 1943 substituted with Phosphoserine" [UniProtKB:P35579] xref: UniProtKB:P35579 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019193 ! MYH9_HUMAN [Term] id: CCO:B0035474 name: PSA5_HUMAN-N-acetylmethionine1 def: "Protein PSA5_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P28066] xref: UniProtKB:P28066 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000644 ! endopeptidase activity relationship: has_function CCO:F0000721 ! threonine endopeptidase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001783 ! peptidase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: located_in CCO:C0002080 ! proteasome core complex relationship: transformation_of CCO:B0022204 ! PSA5_HUMAN [Term] id: CCO:B0035475 name: PSA5_HUMAN-Phosphoserine16 def: "Protein PSA5_HUMAN with the residue 16 substituted with Phosphoserine" [UniProtKB:P28066] xref: UniProtKB:P28066 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0022204 ! PSA5_HUMAN [Term] id: CCO:B0035476 name: PSA5_HUMAN-Phosphoserine56 def: "Protein PSA5_HUMAN with the residue 56 substituted with Phosphoserine" [UniProtKB:P28066] xref: UniProtKB:P28066 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0022204 ! PSA5_HUMAN [Term] id: CCO:B0035477 name: PSA7_HUMAN-N-acetylserine2 def: "Protein PSA7_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:O14818] xref: UniProtKB:O14818 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0030768 ! PSA7_HUMAN [Term] id: CCO:B0035478 name: PSB1_HUMAN-Phosphotyrosine150 def: "Protein PSB1_HUMAN with the residue 150 substituted with Phosphotyrosine" [UniProtKB:P20618] comment: By similarity xref: UniProtKB:P20618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000721 ! threonine endopeptidase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001783 ! peptidase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: located_in CCO:C0002080 ! proteasome core complex relationship: transformation_of CCO:B0030961 ! PSB1_HUMAN [Term] id: CCO:B0035479 name: PSB2_HUMAN-N-acetylmethionine1 def: "Protein PSB2_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P49721] xref: UniProtKB:P49721 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0030800 ! PSB2_HUMAN [Term] id: CCO:B0035480 name: PSB3_HUMAN-N-acetylserine2 def: "Protein PSB3_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P49720] comment: By similarity xref: UniProtKB:P49720 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0030929 ! PSB3_HUMAN [Term] id: CCO:B0035481 name: PSB7_HUMAN-Phosphotyrosine154 def: "Protein PSB7_HUMAN with the residue 154 substituted with Phosphotyrosine" [UniProtKB:Q99436] xref: UniProtKB:Q99436 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:B0035483 name: PSD7_HUMAN-Phosphothreonine186 def: "Protein PSD7_HUMAN with the residue 186 substituted with Phosphothreonine" [UniProtKB:P51665] xref: UniProtKB:P51665 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0031003 ! PSD7_HUMAN [Term] id: CCO:B0035484 name: PSDE_HUMAN-Phosphotyrosine32 def: "Protein PSDE_HUMAN with the residue 32 substituted with Phosphotyrosine" [UniProtKB:O00487] xref: UniProtKB:O00487 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0023606 ! PSDE_HUMAN [Term] id: CCO:B0035485 name: PSDE_HUMAN-Phosphoserine224 def: "Protein PSDE_HUMAN with the residue 224 substituted with Phosphoserine" [UniProtKB:O00487] xref: UniProtKB:O00487 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0023606 ! PSDE_HUMAN [Term] id: CCO:B0035935 name: MEN1_HUMAN def: "Menin" [UniProtKB:O00255] xref: EMBL:AAC51228.1 xref: EMBL:AAC51229.1 xref: EMBL:AAC51230.1 xref: EMBL:AAH02544.1 xref: UniProtKB:O00255 xref: UniProtKB:O00632 xref: UniProtKB:Q9BUK2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0010895 ! MEN1_human relationship: has_function CCO:F0000082 ! four-way junction DNA binding relationship: has_function CCO:F0000085 ! Y-form DNA binding relationship: has_function CCO:F0000282 ! double-stranded DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003617 ! histone-lysine N-methyltransferase activity relationship: has_function CCO:F0006174 ! SMAD binding relationship: has_function CCO:F0006791 ! protein N-terminus binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000112 ! chromatin relationship: located_in CCO:C0000245 ! soluble fraction relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0000785 ! nuclear matrix relationship: located_in CCO:C0001403 ! cleavage furrow relationship: located_in CCO:C0001616 ! histone methyltransferase complex relationship: located_in CCO:C0001750 ! protein complex relationship: participates_in CCO:I0006305 ! mll-hcfc2-2 physical interaction relationship: participates_in CCO:I0008564 ! menin-myh9-1 physical interaction relationship: participates_in CCO:I0008567 ! menin-myh9-6 physical interaction relationship: participates_in CCO:I0008569 ! mll-hcfc2-1 physical interaction relationship: participates_in CCO:I0008576 ! menin-myh9-4 direct interaction relationship: participates_in CCO:I0008577 ! myh9-menin-1 direct interaction relationship: participates_in CCO:I0008579 ! menin-myh9-3 physical interaction relationship: participates_in CCO:I0008581 ! menin-myh9-2 physical interaction relationship: participates_in CCO:I0008582 ! menin-myh9-5 colocalization relationship: participates_in CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0036013 ! MEN1_HUMAN-Phosphoserine399 [Term] id: CCO:B0035936 name: RNF8_HUMAN def: "E3 ubiquitin-protein ligase RNF8" [UniProtKB:O76064] synonym: "EC 6.3.2.-" EXACT [UniProtKB:O76064] synonym: "RING finger protein 8" EXACT [UniProtKB:O76064] xref: EMBL:AAH07517.1 xref: EMBL:AAP36114.1 xref: EMBL:AAQ14887.1 xref: EMBL:BAA31621.2 xref: EMBL:BAA33557.1 xref: EMBL:BAD96485.1 xref: EMBL:CAB75689.1 xref: EMBL:EAX03944.1 xref: UniProtKB:O76064 xref: UniProtKB:Q53H16 xref: UniProtKB:Q5NKW5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0010897 ! RNF8_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0003433 ! ligase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0008568 ! rrp4-rnf8 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0035937 name: S26A8_HUMAN def: "Testis anion transporter 1" [UniProtKB:Q96RN1] synonym: "Anion exchange transporter" EXACT [UniProtKB:Q96RN1] synonym: "Solute carrier family 26 member 8" EXACT [UniProtKB:Q96RN1] xref: EMBL:AAH25408.1 xref: EMBL:AAK95666.1 xref: EMBL:AAL26868.1 xref: EMBL:AAO26699.1 xref: EMBL:BAB71408.1 xref: EMBL:CAI19692.1 xref: EMBL:CAI40882.1 xref: EMBL:CAI40884.1 xref: EMBL:EAX03862.1 xref: UniProtKB:Q5JVR5 xref: UniProtKB:Q812C7 xref: UniProtKB:Q8TC65 xref: UniProtKB:Q96MA0 xref: UniProtKB:Q96PK8 xref: UniProtKB:Q96RN1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0012899 ! SLC26A8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0035938 name: SETD8_HUMAN def: "Histone-lysine N-methyltransferase SETD8" [UniProtKB:Q9NQR1] synonym: "EC 2.1.1.43" EXACT [UniProtKB:Q9NQR1] synonym: "H4-K20-HMTase SETD8" EXACT [UniProtKB:Q9NQR1] synonym: "Lysine N-methyltransferase 5A" EXACT [UniProtKB:Q9NQR1] synonym: "PR-Set7" EXACT [UniProtKB:Q9NQR1] synonym: "PR/SET domain-containing protein 07" EXACT [UniProtKB:Q9NQR1] synonym: "PR/SET07" EXACT [UniProtKB:Q9NQR1] synonym: "SET domain-containing protein 8" EXACT [UniProtKB:Q9NQR1] xref: EMBL:AAF97812.2 xref: EMBL:AAH50346.1 xref: EMBL:AAL40879.1 xref: EMBL:AAM47033.1 xref: UniProtKB:Q86W83 xref: UniProtKB:Q8TD09 xref: UniProtKB:Q9NQR1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0010898 ! SETD8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0035939 name: C8AP2_HUMAN def: "CASP8-associated protein 2" [UniProtKB:Q9UKL3] synonym: "FLICE-associated huge protein" EXACT [UniProtKB:Q9UKL3] xref: EMBL:AAD45157.1 xref: EMBL:AAD45537.2 xref: EMBL:AAF03367.1 xref: EMBL:AAH42577.1 xref: EMBL:AAH56685.1 xref: EMBL:BAA92067.1 xref: EMBL:BAA92553.2 xref: UniProtKB:Q6PH76 xref: UniProtKB:Q7LCQ7 xref: UniProtKB:Q86YD9 xref: UniProtKB:Q9NUQ4 xref: UniProtKB:Q9NZV9 xref: UniProtKB:Q9P2N1 xref: UniProtKB:Q9UKL3 xref: UniProtKB:Q9Y563 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0010892 ! CASP8AP2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0035988 ! C8AP2_HUMAN-Phosphoserine1278 [Term] id: CCO:B0035951 name: THOP1_HUMAN def: "Thimet oligopeptidase" [UniProtKB:P52888] synonym: "EC 3.4.24.15" EXACT [UniProtKB:P52888] synonym: "Endopeptidase 24.15" EXACT [UniProtKB:P52888] synonym: "MP78" EXACT [UniProtKB:P52888] xref: EMBL:AAA82607.1 xref: EMBL:AAD13118.1 xref: EMBL:AAH00135.1 xref: EMBL:AAH02391.1 xref: EMBL:CAA90477.1 xref: UniProtKB:P52888 xref: UniProtKB:Q9UCB3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005084 ! THOP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0006487 ! mphosph6-thop1 physical interaction relationship: transforms_into CCO:B0036035 ! THOP1_HUMAN-Phosphotyrosine278 [Term] id: CCO:B0035952 name: ACACA_HUMAN def: "Acetyl-CoA carboxylase 1" [UniProtKB:Q13085] synonym: "ACC-alpha" EXACT [UniProtKB:Q13085] synonym: "EC 6.4.1.2" EXACT [UniProtKB:Q13085] xref: EMBL:AAC50139.1 xref: EMBL:AAP69841.1 xref: EMBL:AAP94114.1 xref: EMBL:AAP94115.1 xref: EMBL:AAP94116.1 xref: EMBL:AAP94118.1 xref: EMBL:AAP94120.1 xref: EMBL:AAP94122.1 xref: EMBL:CAD59556.1 xref: EMBL:CAD59557.1 xref: EMBL:CAD92089.1 xref: UniProtKB:Q13085 xref: UniProtKB:Q6KEV6 xref: UniProtKB:Q6XDA8 xref: UniProtKB:Q7Z2G8 xref: UniProtKB:Q7Z561 xref: UniProtKB:Q7Z563 xref: UniProtKB:Q7Z564 xref: UniProtKB:Q86WB2 xref: UniProtKB:Q86WB3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004383 ! ACACA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007019 ! acaca-brca1-1 physical interaction relationship: participates_in CCO:I0007801 ! acaca-brca1 physical interaction relationship: transforms_into CCO:B0035968 ! ACACA_HUMAN-Phosphoserine23 relationship: transforms_into CCO:B0035969 ! ACACA_HUMAN-Phosphoserine25 relationship: transforms_into CCO:B0035970 ! ACACA_HUMAN-Phosphoserine29 relationship: transforms_into CCO:B0035971 ! ACACA_HUMAN-Phosphoserine48 relationship: transforms_into CCO:B0035972 ! ACACA_HUMAN-Phosphoserine50 relationship: transforms_into CCO:B0035973 ! ACACA_HUMAN-Phosphoserine53 relationship: transforms_into CCO:B0035974 ! ACACA_HUMAN-Phosphoserine56 relationship: transforms_into CCO:B0035975 ! ACACA_HUMAN-Phosphothreonine58 relationship: transforms_into CCO:B0035976 ! ACACA_HUMAN-Phosphoserine60 relationship: transforms_into CCO:B0035977 ! ACACA_HUMAN-Phosphoserine78 relationship: transforms_into CCO:B0035978 ! ACACA_HUMAN-Phosphoserine80 relationship: transforms_into CCO:B0035979 ! ACACA_HUMAN-Phosphothreonine1042 relationship: transforms_into CCO:B0035980 ! ACACA_HUMAN-Phosphoserine1201 relationship: transforms_into CCO:B0035981 ! ACACA_HUMAN-Phosphoserine1263 relationship: transforms_into CCO:B0035982 ! ACACA_HUMAN-Phosphoserine1844 relationship: transforms_into CCO:B0035983 ! ACACA_HUMAN-Phosphoserine2099 relationship: transforms_into CCO:B0035984 ! ACACA_HUMAN-Phosphotyrosine2108 [Term] id: CCO:B0035953 name: YB008_HUMAN def: "Uncharacterized protein FLJ20309" [UniProtKB:Q53TQ3] xref: EMBL:AAH04193.2 xref: EMBL:AAH11687.1 xref: EMBL:AAH17290.2 xref: EMBL:AAX93069.1 xref: EMBL:BAA91079.1 xref: UniProtKB:Q53TQ3 xref: UniProtKB:Q6PJC6 xref: UniProtKB:Q6PJU1 xref: UniProtKB:Q6PKA1 xref: UniProtKB:Q9NXD5 is_a: CCO:U0000007 ! cell cycle protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007779 ! flj20309-ruvbl-2 physical interaction [Term] id: CCO:B0035954 name: YG012_HUMAN def: "Uncharacterized protein DKFZP564O0523" [UniProtKB:Q5RL73] xref: EMBL:AAH33561.1 xref: EMBL:AAH44570.1 xref: EMBL:AAI04866.1 xref: EMBL:AAI04868.1 xref: EMBL:BAB70806.1 xref: EMBL:CAI45942.1 xref: EMBL:EAL24148.1 xref: EMBL:EAW76839.1 xref: UniProtKB:Q5H9T2 xref: UniProtKB:Q5RL73 xref: UniProtKB:Q8IYW7 xref: UniProtKB:Q96NS0 is_a: CCO:U0000007 ! cell cycle protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008082 ! cdkn2c-dkfzp564o0523 physical interaction relationship: participates_in CCO:I0008238 ! smpd3-dkfzp564o0523 physical interaction relationship: participates_in CCO:I0008269 ! mnat1-dkfzp564o0523 physical interaction relationship: participates_in CCO:I0008273 ! mphosph6-dkfzp564o05 physical interaction [Term] id: CCO:B0035955 name: CXCL7_HUMAN def: "Platelet basic protein precursor" [UniProtKB:P02775] synonym: "C-X-C motif chemokine 7" EXACT [UniProtKB:P02775] synonym: "LDGF" EXACT [UniProtKB:P02775] synonym: "Leukocyte-derived growth factor" EXACT [UniProtKB:P02775] synonym: "Macrophage-derived growth factor" EXACT [UniProtKB:P02775] synonym: "MDGF" EXACT [UniProtKB:P02775] synonym: "PBP" EXACT [UniProtKB:P02775] synonym: "Small-inducible cytokine B7" EXACT [UniProtKB:P02775] xref: EMBL:AAA62836.1 xref: EMBL:AAH28217.1 xref: EMBL:AAK29642.1 xref: EMBL:AAY41004.1 xref: EMBL:CAG33086.1 xref: UniProtKB:P02775 xref: UniProtKB:Q6IBJ8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005575 ! PPBP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008469 ! dmwd-ppbp physical interaction [Term] id: CCO:B0035967 name: 2A5D_HUMAN-Phosphothreonine553 def: "Protein 2A5D_HUMAN with the residue 553 substituted with Phosphothreonine" [UniProtKB:Q14738] xref: UniProtKB:Q14738 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005515 ! 2A5D_HUMAN [Term] id: CCO:B0035968 name: ACACA_HUMAN-Phosphoserine23 def: "Protein ACACA_HUMAN with the residue 23 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035969 name: ACACA_HUMAN-Phosphoserine25 def: "Protein ACACA_HUMAN with the residue 25 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035970 name: ACACA_HUMAN-Phosphoserine29 def: "Protein ACACA_HUMAN with the residue 29 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035971 name: ACACA_HUMAN-Phosphoserine48 def: "Protein ACACA_HUMAN with the residue 48 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035972 name: ACACA_HUMAN-Phosphoserine50 def: "Protein ACACA_HUMAN with the residue 50 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035973 name: ACACA_HUMAN-Phosphoserine53 def: "Protein ACACA_HUMAN with the residue 53 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035974 name: ACACA_HUMAN-Phosphoserine56 def: "Protein ACACA_HUMAN with the residue 56 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035975 name: ACACA_HUMAN-Phosphothreonine58 def: "Protein ACACA_HUMAN with the residue 58 substituted with Phosphothreonine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035976 name: ACACA_HUMAN-Phosphoserine60 def: "Protein ACACA_HUMAN with the residue 60 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035977 name: ACACA_HUMAN-Phosphoserine78 def: "Protein ACACA_HUMAN with the residue 78 substituted with Phosphoserine" [UniProtKB:Q13085] comment: By similarity xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035978 name: ACACA_HUMAN-Phosphoserine80 def: "Protein ACACA_HUMAN with the residue 80 substituted with Phosphoserine" [UniProtKB:Q13085] comment: By similarity xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035979 name: ACACA_HUMAN-Phosphothreonine1042 def: "Protein ACACA_HUMAN with the residue 1042 substituted with Phosphothreonine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035980 name: ACACA_HUMAN-Phosphoserine1201 def: "Protein ACACA_HUMAN with the residue 1201 substituted with Phosphoserine" [UniProtKB:Q13085] comment: By similarity xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035981 name: ACACA_HUMAN-Phosphoserine1263 def: "Protein ACACA_HUMAN with the residue 1263 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035982 name: ACACA_HUMAN-Phosphoserine1844 def: "Protein ACACA_HUMAN with the residue 1844 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035983 name: ACACA_HUMAN-Phosphoserine2099 def: "Protein ACACA_HUMAN with the residue 2099 substituted with Phosphoserine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035984 name: ACACA_HUMAN-Phosphotyrosine2108 def: "Protein ACACA_HUMAN with the residue 2108 substituted with Phosphotyrosine" [UniProtKB:Q13085] xref: UniProtKB:Q13085 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:B0035985 name: ACVR1_HUMAN-Phosphoserine501 def: "Protein ACVR1_HUMAN with the residue 501 substituted with Phosphoserine" [UniProtKB:Q04771] xref: UniProtKB:Q04771 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000059 ! magnesium ion binding relationship: has_function CCO:F0001043 ! protein kinase activity relationship: has_function CCO:F0001045 ! protein serine/threonine kinase activity relationship: has_function CCO:F0001046 ! transmembrane receptor protein serine/threonine kinase activity relationship: has_function CCO:F0001068 ! receptor signaling protein serine/threonine kinase activity relationship: has_function CCO:F0001226 ! receptor activity relationship: has_function CCO:F0001354 ! transforming growth factor beta receptor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003114 ! kinase activity relationship: has_function CCO:F0003122 ! activin receptor activity, type I relationship: has_function CCO:F0003316 ! transferase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_function CCO:F0006174 ! SMAD binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_function CCO:F0007318 ! follistatin binding relationship: has_function CCO:F0007319 ! activin binding relationship: has_function CCO:F0007780 ! transforming growth factor beta binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000445 ! integral to plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: located_in CCO:C0001980 ! activin receptor complex relationship: transformation_of CCO:B0001720 ! ACVR1_HUMAN [Term] id: CCO:B0035986 name: BPAEA_HUMAN-Phosphothreonine4352 def: "Protein BPAEA_HUMAN with the residue 4352 substituted with Phosphothreonine" [UniProtKB:O94833] xref: UniProtKB:O94833 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001443 ! BPAEA_HUMAN [Term] id: CCO:B0035987 name: BUB1B_HUMAN-Phosphothreonine54 def: "Protein BUB1B_HUMAN with the residue 54 substituted with Phosphothreonine" [UniProtKB:O60566] xref: UniProtKB:O60566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001411 ! BUB1B_HUMAN [Term] id: CCO:B0035988 name: C8AP2_HUMAN-Phosphoserine1278 def: "Protein C8AP2_HUMAN with the residue 1278 substituted with Phosphoserine" [UniProtKB:Q9UKL3] xref: UniProtKB:Q9UKL3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035939 ! C8AP2_HUMAN [Term] id: CCO:B0035989 name: CAND1_HUMAN-Phosphothreonine624 def: "Protein CAND1_HUMAN with the residue 624 substituted with Phosphothreonine" [UniProtKB:Q86VP6] xref: UniProtKB:Q86VP6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:B0035990 name: CCNG2_HUMAN-Phosphoserine220 def: "Protein CCNG2_HUMAN with the residue 220 substituted with Phosphoserine" [UniProtKB:Q16589] xref: UniProtKB:Q16589 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001821 ! CCNG2_HUMAN [Term] id: CCO:B0035991 name: CCNG2_HUMAN-Phosphoserine234 def: "Protein CCNG2_HUMAN with the residue 234 substituted with Phosphoserine" [UniProtKB:Q16589] xref: UniProtKB:Q16589 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001821 ! CCNG2_HUMAN [Term] id: CCO:B0035992 name: CHD3_HUMAN-Phosphoserine43 def: "Protein CHD3_HUMAN with the residue 43 substituted with Phosphoserine" [UniProtKB:Q12873] xref: UniProtKB:Q12873 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006082 ! CHD3_HUMAN [Term] id: CCO:B0035993 name: CLAP2_HUMAN-Phosphoserine523 def: "Protein CLAP2_HUMAN with the residue 523 substituted with Phosphoserine" [UniProtKB:O75122] xref: UniProtKB:O75122 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001422 ! CLAP2_HUMAN [Term] id: CCO:B0035994 name: CLIP1_HUMAN-Phosphothreonine822 def: "Protein CLIP1_HUMAN with the residue 822 substituted with Phosphothreonine" [UniProtKB:P30622] xref: UniProtKB:P30622 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001580 ! CLIP1_HUMAN [Term] id: CCO:B0035995 name: CNDD3_HUMAN-Phosphoserine1357 def: "Protein CNDD3_HUMAN with the residue 1357 substituted with Phosphoserine" [UniProtKB:P42695] xref: UniProtKB:P42695 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001614 ! CNDD3_HUMAN [Term] id: CCO:B0035996 name: CUL4A_HUMAN-Phosphotyrosine227 def: "Protein CUL4A_HUMAN with the residue 227 substituted with Phosphotyrosine" [UniProtKB:Q13619] xref: UniProtKB:Q13619 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001762 ! CUL4A_HUMAN [Term] id: CCO:B0035997 name: DCC_HUMAN-Phosphoserine1073 def: "Protein DCC_HUMAN with the residue 1073 substituted with Phosphoserine" [UniProtKB:P43146] xref: UniProtKB:P43146 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001226 ! receptor activity relationship: has_function CCO:F0001240 ! transmembrane receptor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000445 ! integral to plasma membrane relationship: located_in CCO:C0000766 ! membrane relationship: located_in CCO:C0000767 ! integral to membrane relationship: transformation_of CCO:B0001619 ! DCC_HUMAN [Term] id: CCO:B0035998 name: DCC_HUMAN-Phosphothreonine1074 def: "Protein DCC_HUMAN with the residue 1074 substituted with Phosphothreonine" [UniProtKB:P43146] xref: UniProtKB:P43146 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001619 ! DCC_HUMAN [Term] id: CCO:B0035999 name: DNL4_HUMAN-Phosphothreonine347 def: "Protein DNL4_HUMAN with the residue 347 substituted with Phosphothreonine" [UniProtKB:P49917] xref: UniProtKB:P49917 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001639 ! DNL4_HUMAN [Term] id: CCO:B0036000 name: EID1_HUMAN-Phosphoserine2 def: "Protein EID1_HUMAN with the residue 2 substituted with Phosphoserine" [UniProtKB:Q9Y6B2] xref: UniProtKB:Q9Y6B2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002263 ! EID1_HUMAN [Term] id: CCO:B0036001 name: EID1_HUMAN-Phosphoserine8 def: "Protein EID1_HUMAN with the residue 8 substituted with Phosphoserine" [UniProtKB:Q9Y6B2] xref: UniProtKB:Q9Y6B2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002263 ! EID1_HUMAN [Term] id: CCO:B0036002 name: ERCC3_HUMAN-Phosphoserine370 def: "Protein ERCC3_HUMAN with the residue 370 substituted with Phosphoserine" [UniProtKB:P19447] xref: UniProtKB:P19447 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0028502 ! ERCC3_HUMAN [Term] id: CCO:B0036003 name: ESR1_HUMAN-Phosphothreonine7 def: "Protein ESR1_HUMAN with the residue 7 substituted with Phosphothreonine" [UniProtKB:P03372] xref: UniProtKB:P03372 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:B0036004 name: ESR1_HUMAN-Phosphoserine10 def: "Protein ESR1_HUMAN with the residue 10 substituted with Phosphoserine" [UniProtKB:P03372] xref: UniProtKB:P03372 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:B0036005 name: FOXO4_HUMAN-Phosphoserine111 def: "Protein FOXO4_HUMAN with the residue 111 substituted with Phosphoserine" [UniProtKB:P98177] xref: UniProtKB:P98177 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001706 ! FOXO4_HUMAN [Term] id: CCO:B0036006 name: FOXO4_HUMAN-Phosphoserine200 def: "Protein FOXO4_HUMAN with the residue 200 substituted with Phosphoserine" [UniProtKB:P98177] xref: UniProtKB:P98177 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001706 ! FOXO4_HUMAN [Term] id: CCO:B0036007 name: FZR_HUMAN-Phosphotyrosine91 def: "Protein FZR_HUMAN with the residue 91 substituted with Phosphotyrosine" [UniProtKB:Q9UM11] xref: UniProtKB:Q9UM11 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002229 ! FZR_HUMAN [Term] id: CCO:B0036008 name: FZR_HUMAN-Phosphoserine92 def: "Protein FZR_HUMAN with the residue 92 substituted with Phosphoserine" [UniProtKB:Q9UM11] xref: UniProtKB:Q9UM11 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002229 ! FZR_HUMAN [Term] id: CCO:B0036010 name: KI67_HUMAN-Phosphoserine352 def: "Protein KI67_HUMAN with the residue 352 substituted with Phosphoserine" [UniProtKB:P46013] xref: UniProtKB:P46013 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001622 ! KI67_HUMAN [Term] id: CCO:B0036011 name: M3K1_HUMAN-Phosphothreonine657 def: "Protein M3K1_HUMAN with the residue 657 substituted with Phosphothreonine" [UniProtKB:Q13233] xref: UniProtKB:Q13233 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005525 ! M3K1_HUMAN [Term] id: CCO:B0036012 name: M3K1_HUMAN-Phosphothreonine665 def: "Protein M3K1_HUMAN with the residue 665 substituted with Phosphothreonine" [UniProtKB:Q13233] xref: UniProtKB:Q13233 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005525 ! M3K1_HUMAN [Term] id: CCO:B0036013 name: MEN1_HUMAN-Phosphoserine399 def: "Protein MEN1_HUMAN with the residue 399 substituted with Phosphoserine" [UniProtKB:O00255] xref: UniProtKB:O00255 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:B0036014 name: MLH3_HUMAN-Phosphothreonine606 def: "Protein MLH3_HUMAN with the residue 606 substituted with Phosphothreonine" [UniProtKB:Q9UHC1] xref: UniProtKB:Q9UHC1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002200 ! MLH3_HUMAN [Term] id: CCO:B0036015 name: MLH3_HUMAN-Phosphothreonine610 def: "Protein MLH3_HUMAN with the residue 610 substituted with Phosphothreonine" [UniProtKB:Q9UHC1] xref: UniProtKB:Q9UHC1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002200 ! MLH3_HUMAN [Term] id: CCO:B0036016 name: MLTK_HUMAN-Phosphoserine633 def: "Protein MLTK_HUMAN with the residue 633 substituted with Phosphoserine" [UniProtKB:Q9NYL2] xref: UniProtKB:Q9NYL2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002178 ! MLTK_HUMAN [Term] id: CCO:B0036017 name: MYH10_HUMAN-Phosphothreonine1376 def: "Protein MYH10_HUMAN with the residue 1376 substituted with Phosphothreonine" [UniProtKB:P35580] xref: UniProtKB:P35580 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000026 ! microfilament motor activity relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000321 ! motor activity relationship: has_function CCO:F0000323 ! actin binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001647 ! calmodulin binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0004599 ! actin-dependent ATPase activity relationship: has_function CCO:F0005867 ! ADP binding relationship: has_function CCO:F0008035 ! actin filament binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000180 ! stress fiber relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000489 ! cell cortex relationship: located_in CCO:C0000788 ! myosin complex relationship: located_in CCO:C0001017 ! midbody relationship: located_in CCO:C0001403 ! cleavage furrow relationship: transformation_of CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:B0036018 name: NCOR2_HUMAN-Phosphoserine956 def: "Protein NCOR2_HUMAN with the residue 956 substituted with Phosphoserine" [UniProtKB:Q9Y618] xref: UniProtKB:Q9Y618 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:B0036019 name: NIPA_HUMAN-Phosphothreonine84 def: "Protein NIPA_HUMAN with the residue 84 substituted with Phosphothreonine" [UniProtKB:Q86WB0] xref: UniProtKB:Q86WB0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001941 ! NIPA_HUMAN [Term] id: CCO:B0036020 name: PDCD4_HUMAN-Phosphoserine94 def: "Protein PDCD4_HUMAN with the residue 94 substituted with Phosphoserine" [UniProtKB:Q53EL6] xref: UniProtKB:Q53EL6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001836 ! PDCD4_HUMAN [Term] id: CCO:B0036021 name: PDS5B_HUMAN-Phosphoserine1379 def: "Protein PDS5B_HUMAN with the residue 1379 substituted with Phosphoserine" [UniProtKB:Q9NTI5] xref: UniProtKB:Q9NTI5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026257 ! PDS5B_HUMAN [Term] id: CCO:B0036022 name: PR15A_HUMAN-Phosphotyrosine262 def: "Protein PR15A_HUMAN with the residue 262 substituted with Phosphotyrosine" [UniProtKB:O75807] xref: UniProtKB:O75807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001436 ! PR15A_HUMAN [Term] id: CCO:B0036023 name: PR15A_HUMAN-Phosphoserine264 def: "Protein PR15A_HUMAN with the residue 264 substituted with Phosphoserine" [UniProtKB:O75807] xref: UniProtKB:O75807 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000364 ! endoplasmic reticulum relationship: transformation_of CCO:B0001436 ! PR15A_HUMAN [Term] id: CCO:B0036024 name: PTN6_HUMAN-Phosphotyrosine509 def: "Protein PTN6_HUMAN with the residue 509 substituted with Phosphotyrosine" [UniProtKB:P29350] xref: UniProtKB:P29350 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005608 ! PTN6_HUMAN [Term] id: CCO:B0036025 name: RANB3_HUMAN-Phosphoserine333 def: "Protein RANB3_HUMAN with the residue 333 substituted with Phosphoserine" [UniProtKB:Q9H6Z4] xref: UniProtKB:Q9H6Z4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:B0036026 name: RBL2_HUMAN-Phosphothreonine1019 def: "Protein RBL2_HUMAN with the residue 1019 substituted with Phosphothreonine" [UniProtKB:Q08999] xref: UniProtKB:Q08999 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001725 ! RBL2_HUMAN [Term] id: CCO:B0036027 name: REN3A_HUMAN-Phosphoserine68 def: "Protein REN3A_HUMAN with the residue 68 substituted with Phosphoserine" [UniProtKB:Q9H1J1] xref: UniProtKB:Q9H1J1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005436 ! REN3A_HUMAN [Term] id: CCO:B0036028 name: RL21_HUMAN-Phosphothreonine47 def: "Protein RL21_HUMAN with the residue 47 substituted with Phosphothreonine" [UniProtKB:P46778] xref: UniProtKB:P46778 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005862 ! RL21_HUMAN [Term] id: CCO:B0036029 name: RLA2_HUMAN-Phosphoserine16 def: "Protein RLA2_HUMAN with the residue 16 substituted with Phosphoserine" [UniProtKB:P05387] xref: UniProtKB:P05387 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005864 ! RLA2_HUMAN [Term] id: CCO:B0036030 name: RS13_HUMAN-Phosphoserine30 def: "Protein RS13_HUMAN with the residue 30 substituted with Phosphoserine" [UniProtKB:P62277] xref: UniProtKB:P62277 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005748 ! RS13_HUMAN [Term] id: CCO:B0036031 name: SMRC2_HUMAN-Phosphoserine806 def: "Protein SMRC2_HUMAN with the residue 806 substituted with Phosphoserine" [UniProtKB:Q8TAQ2] xref: UniProtKB:Q8TAQ2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005417 ! SMRC2_HUMAN [Term] id: CCO:B0036034 name: TFDP1_HUMAN-Phosphoserine183 def: "Protein TFDP1_HUMAN with the residue 183 substituted with Phosphoserine" [UniProtKB:Q14186] xref: UniProtKB:Q14186 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001776 ! TFDP1_HUMAN [Term] id: CCO:B0036035 name: THOP1_HUMAN-Phosphotyrosine278 def: "Protein THOP1_HUMAN with the residue 278 substituted with Phosphotyrosine" [UniProtKB:P52888] comment: By similarity xref: UniProtKB:P52888 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0035951 ! THOP1_HUMAN [Term] id: CCO:B0036036 name: TITIN_HUMAN-Phosphoserine4065 def: "Protein TITIN_HUMAN with the residue 4065 substituted with Phosphoserine" [UniProtKB:Q8WZ42] xref: UniProtKB:Q8WZ42 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:B0036037 name: TITIN_HUMAN-Phosphoserine4068 def: "Protein TITIN_HUMAN with the residue 4068 substituted with Phosphoserine" [UniProtKB:Q8WZ42] xref: UniProtKB:Q8WZ42 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:B0036038 name: TLE3_HUMAN-Phosphoserine205 def: "Protein TLE3_HUMAN with the residue 205 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0036039 name: TLE3_HUMAN-Phosphoserine292 def: "Protein TLE3_HUMAN with the residue 292 substituted with Phosphoserine" [UniProtKB:Q04726] xref: UniProtKB:Q04726 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005690 ! TLE3_HUMAN [Term] id: CCO:B0036040 name: WAPL_HUMAN-Phosphoserine223 def: "Protein WAPL_HUMAN with the residue 223 substituted with Phosphoserine" [UniProtKB:Q7Z5K2] xref: UniProtKB:Q7Z5K2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:B0036272 name: ANM6_HUMAN def: "Protein arginine N-methyltransferase 6" [UniProtKB:Q96LA8] synonym: "EC 2.1.1.-" EXACT [UniProtKB:Q96LA8] synonym: "Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6" EXACT [UniProtKB:Q96LA8] xref: EMBL:AAH02729.3 xref: EMBL:AAH73866.1 xref: EMBL:AAK85733.1 xref: EMBL:BAA91681.1 xref: EMBL:CAI19090.1 xref: EMBL:EAW51248.1 xref: UniProtKB:Q5T5Y5 xref: UniProtKB:Q6DKI4 xref: UniProtKB:Q96LA8 xref: UniProtKB:Q9NVR8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0011243 ! PRMT6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008768 ! hrmt1l6-hmg2a physical interaction relationship: participates_in CCO:I0008770 ! hrmt1l6-hmga2 physical interaction [Term] id: CCO:B0036469 name: HCFC2_HUMAN def: "Host cell factor 2" [UniProtKB:Q9Y5Z7] synonym: "C2 factor" EXACT [UniProtKB:Q9Y5Z7] synonym: "HCF-2" EXACT [UniProtKB:Q9Y5Z7] xref: EMBL:AAD27814.1 xref: EMBL:AAH33799.1 xref: UniProtKB:Q9Y5Z7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0011455 ! HCFC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008569 ! mll-hcfc2-1 physical interaction [Term] id: CCO:B0038144 name: PSD12_HUMAN def: "26S proteasome non-ATPase regulatory subunit 12" [UniProtKB:O00232] synonym: "26S proteasome regulatory subunit p55" EXACT [UniProtKB:O00232] xref: EMBL:AAH19062.1 xref: EMBL:AAH65826.1 xref: EMBL:BAA19749.1 xref: EMBL:BAD96399.1 xref: UniProtKB:O00232 xref: UniProtKB:Q53HA2 xref: UniProtKB:Q6P053 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0011633 ! PSMD12_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008717 ! traf6-psmd12 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0039598 ! PSD12_HUMAN-N-acetylalanine2 [Term] id: CCO:B0039597 name: PRS10_HUMAN-N-acetylalanine2 def: "Protein PRS10_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P62333] xref: UniProtKB:P62333 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0003445 ! ATPase activity relationship: has_function CCO:F0003574 ! nucleoside-triphosphatase activity relationship: has_function CCO:F0004516 ! protein binding, bridging relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: transformation_of CCO:B0030905 ! PRS10_HUMAN [Term] id: CCO:B0039598 name: PSD12_HUMAN-N-acetylalanine2 def: "Protein PSD12_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:O00232] xref: UniProtKB:O00232 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0038144 ! PSD12_HUMAN [Term] id: CCO:B0039756 name: FEN1_HUMAN def: "Flap endonuclease 1" [UniProtKB:P39748] synonym: "DNase IV" EXACT [UniProtKB:P39748] synonym: "EC 3.1.-.-" EXACT [UniProtKB:P39748] synonym: "FEN-1" EXACT [UniProtKB:P39748] synonym: "Flap structure-specific endonuclease 1" EXACT [UniProtKB:P39748] synonym: "hFEN-1" EXACT [UniProtKB:P39748] synonym: "Maturation factor 1" EXACT [UniProtKB:P39748] synonym: "MF1" EXACT [UniProtKB:P39748] xref: EMBL:AAA91331.1 xref: EMBL:AAC23394.1 xref: EMBL:AAH00323.1 xref: EMBL:AAM74238.1 xref: EMBL:CAA54166.1 xref: UniProtKB:P39748 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0012898 ! FEN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008562 ! blm-fen1-2 physical interaction relationship: participates_in CCO:I0008563 ! blm-fen1-4 physical interaction relationship: participates_in CCO:I0008580 ! blm-fen1-1 direct interaction relationship: participates_in CCO:I0008583 ! blm-fen1-3 direct interaction relationship: transforms_into CCO:B0039763 ! FEN1_HUMAN-N6-acetyllysine354 relationship: transforms_into CCO:B0039764 ! FEN1_HUMAN-N6-acetyllysine375 relationship: transforms_into CCO:B0039765 ! FEN1_HUMAN-N6-acetyllysine377 relationship: transforms_into CCO:B0039766 ! FEN1_HUMAN-N6-acetyllysine380 [Term] id: CCO:B0039757 name: EXOS2_HUMAN def: "Exosome complex exonuclease RRP4" [UniProtKB:Q13868] synonym: "EC 3.1.13.-" EXACT [UniProtKB:Q13868] synonym: "Exosome component 2" EXACT [UniProtKB:Q13868] synonym: "Ribosomal RNA-processing protein 4" EXACT [UniProtKB:Q13868] xref: EMBL:AAB60392.1 xref: EMBL:AAH00747.1 xref: EMBL:BAA91977.1 xref: EMBL:BAB14043.1 xref: UniProtKB:Q13868 xref: UniProtKB:Q9NUY4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0012897 ! EXOSC2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008568 ! rrp4-rnf8 physical interaction relationship: transforms_into CCO:B0039759 ! EXOS2_HUMAN-Phosphothreonine32 relationship: transforms_into CCO:B0039760 ! EXOS2_HUMAN-Phosphothreonine37 relationship: transforms_into CCO:B0039761 ! EXOS2_HUMAN-Phosphothreonine45 relationship: transforms_into CCO:B0039762 ! EXOS2_HUMAN-Phosphotyrosine46 [Term] id: CCO:B0039758 name: UTP18_HUMAN def: "U3 small nucleolar RNA-associated protein 18 homolog" [UniProtKB:Q9Y5J1] synonym: "WD repeat-containing protein 50" EXACT [UniProtKB:Q9Y5J1] xref: EMBL:AAD34043.1 xref: EMBL:AAG01999.1 xref: EMBL:AAH25276.2 xref: UniProtKB:Q9H4N6 xref: UniProtKB:Q9Y5J1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0012900 ! UTP18_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008569 ! mll-hcfc2-1 physical interaction relationship: transforms_into CCO:B0039767 ! UTP18_HUMAN-Phosphoserine121 relationship: transforms_into CCO:B0039768 ! UTP18_HUMAN-Phosphoserine124 relationship: transforms_into CCO:B0039769 ! UTP18_HUMAN-Phosphoserine210 [Term] id: CCO:B0039759 name: EXOS2_HUMAN-Phosphothreonine32 def: "Protein EXOS2_HUMAN with the residue 32 substituted with Phosphothreonine" [UniProtKB:Q13868] xref: UniProtKB:Q13868 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039757 ! EXOS2_HUMAN [Term] id: CCO:B0039760 name: EXOS2_HUMAN-Phosphothreonine37 def: "Protein EXOS2_HUMAN with the residue 37 substituted with Phosphothreonine" [UniProtKB:Q13868] xref: UniProtKB:Q13868 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039757 ! EXOS2_HUMAN [Term] id: CCO:B0039761 name: EXOS2_HUMAN-Phosphothreonine45 def: "Protein EXOS2_HUMAN with the residue 45 substituted with Phosphothreonine" [UniProtKB:Q13868] xref: UniProtKB:Q13868 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039757 ! EXOS2_HUMAN [Term] id: CCO:B0039762 name: EXOS2_HUMAN-Phosphotyrosine46 def: "Protein EXOS2_HUMAN with the residue 46 substituted with Phosphotyrosine" [UniProtKB:Q13868] xref: UniProtKB:Q13868 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039757 ! EXOS2_HUMAN [Term] id: CCO:B0039763 name: FEN1_HUMAN-N6-acetyllysine354 def: "Protein FEN1_HUMAN with the residue 354 substituted with N6-acetyllysine" [UniProtKB:P39748] xref: UniProtKB:P39748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039756 ! FEN1_HUMAN [Term] id: CCO:B0039764 name: FEN1_HUMAN-N6-acetyllysine375 def: "Protein FEN1_HUMAN with the residue 375 substituted with N6-acetyllysine" [UniProtKB:P39748] xref: UniProtKB:P39748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039756 ! FEN1_HUMAN [Term] id: CCO:B0039765 name: FEN1_HUMAN-N6-acetyllysine377 def: "Protein FEN1_HUMAN with the residue 377 substituted with N6-acetyllysine" [UniProtKB:P39748] xref: UniProtKB:P39748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039756 ! FEN1_HUMAN [Term] id: CCO:B0039766 name: FEN1_HUMAN-N6-acetyllysine380 def: "Protein FEN1_HUMAN with the residue 380 substituted with N6-acetyllysine" [UniProtKB:P39748] xref: UniProtKB:P39748 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039756 ! FEN1_HUMAN [Term] id: CCO:B0039767 name: UTP18_HUMAN-Phosphoserine121 def: "Protein UTP18_HUMAN with the residue 121 substituted with Phosphoserine" [UniProtKB:Q9Y5J1] xref: UniProtKB:Q9Y5J1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039758 ! UTP18_HUMAN [Term] id: CCO:B0039768 name: UTP18_HUMAN-Phosphoserine124 def: "Protein UTP18_HUMAN with the residue 124 substituted with Phosphoserine" [UniProtKB:Q9Y5J1] xref: UniProtKB:Q9Y5J1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039758 ! UTP18_HUMAN [Term] id: CCO:B0039769 name: UTP18_HUMAN-Phosphoserine210 def: "Protein UTP18_HUMAN with the residue 210 substituted with Phosphoserine" [UniProtKB:Q9Y5J1] comment: By similarity xref: UniProtKB:Q9Y5J1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039758 ! UTP18_HUMAN [Term] id: CCO:B0039945 name: CRBL2_HUMAN def: "cAMP-responsive element-binding protein-like 2" [UniProtKB:O60519] xref: EMBL:AAC32314.1 xref: EMBL:AAI04874.1 xref: EMBL:AAI06053.1 xref: EMBL:AAI12158.1 xref: EMBL:CAG47046.1 xref: EMBL:EAW96269.1 xref: UniProtKB:O60519 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0012992 ! CREBL2_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0005877 ! sequence-specific DNA binding relationship: has_function CCO:F0006300 ! protein dimerization activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0039946 name: NPAT_HUMAN def: "Protein NPAT" [UniProtKB:Q14207] synonym: "Nuclear protein of the ataxia telangiectasia mutated locus" EXACT [UniProtKB:Q14207] synonym: "Nuclear protein of the ATM locus" EXACT [UniProtKB:Q14207] synonym: "p220" EXACT [UniProtKB:Q14207] xref: EMBL:AAB02735.1 xref: EMBL:AAH40356.1 xref: EMBL:AAH50561.1 xref: EMBL:BAA11861.1 xref: EMBL:BAA21367.1 xref: EMBL:BAF82709.1 xref: EMBL:BAF84376.1 xref: EMBL:CAA65824.1 xref: UniProtKB:A8K1V5 xref: UniProtKB:A8K6M2 xref: UniProtKB:Q13632 xref: UniProtKB:Q14207 xref: UniProtKB:Q14967 xref: UniProtKB:Q16580 xref: UniProtKB:Q86W55 xref: UniProtKB:Q8IWE9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0012995 ! NPAT_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0039951 ! NPAT_HUMAN-Phosphoserine535 relationship: transforms_into CCO:B0039952 ! NPAT_HUMAN-Phosphoserine775 relationship: transforms_into CCO:B0039953 ! NPAT_HUMAN-Phosphoserine779 relationship: transforms_into CCO:B0039954 ! NPAT_HUMAN-Phosphoserine1100 relationship: transforms_into CCO:B0039955 ! NPAT_HUMAN-Phosphothreonine1270 relationship: transforms_into CCO:B0039956 ! NPAT_HUMAN-Phosphothreonine1350 [Term] id: CCO:B0039947 name: STRA8_HUMAN def: "Stimulated by retinoic acid gene 8 protein homolog" [UniProtKB:Q7Z7C7] xref: EMBL:AAP47163.1 xref: EMBL:EAL24061.1 xref: EMBL:EAW83846.1 xref: UniProtKB:Q7Z7C7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0012996 ! STRA8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0039948 name: ZFP42_HUMAN def: "Zinc finger protein 42 homolog" [UniProtKB:Q96MM3] synonym: "hREX-1" EXACT [UniProtKB:Q96MM3] synonym: "Reduced expression protein 1" EXACT [UniProtKB:Q96MM3] synonym: "REX-1" EXACT [UniProtKB:Q96MM3] synonym: "Zfp-42" EXACT [UniProtKB:Q96MM3] synonym: "Zinc finger protein 754" EXACT [UniProtKB:Q96MM3] xref: EMBL:AAL47167.1 xref: EMBL:AAR07993.1 xref: EMBL:BAB71264.1 xref: UniProtKB:Q8WXE2 xref: UniProtKB:Q96MM3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0012997 ! ZFP42_human relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000117 ! meiosis [Term] id: CCO:B0039949 name: FSD1_HUMAN def: "Fibronectin type III and SPRY domain-containing protein 1" [UniProtKB:Q9BTV5] synonym: "Microtubule-associated protein GLFND" EXACT [UniProtKB:Q9BTV5] synonym: "MID1-related protein 1" EXACT [UniProtKB:Q9BTV5] xref: EMBL:AAH03124.1 xref: EMBL:AAK26747.1 xref: EMBL:AAK51145.1 xref: EMBL:BAB13885.1 xref: UniProtKB:Q9BTV5 xref: UniProtKB:Q9BXN0 xref: UniProtKB:Q9HAG4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0012994 ! FSD1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000383 ! centrosome relationship: located_in CCO:C0000434 ! microtubule relationship: participates_in CCO:I0008654 ! ppp1r16a-fsd1 physical interaction relationship: participates_in CCO:I0008655 ! nap1l1-fsd1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0039950 name: DCC1_HUMAN def: "Sister chromatid cohesion protein DCC1" [UniProtKB:Q9BVC3] synonym: "Defective in sister chromatid cohesion protein 1 homolog" EXACT [UniProtKB:Q9BVC3] xref: EMBL:AAH01316.1 xref: EMBL:AAH01531.1 xref: EMBL:AAQ89225.1 xref: EMBL:BAB70767.1 xref: UniProtKB:Q969N5 xref: UniProtKB:Q9BVC3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013374 ! DSCC1_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0039951 name: NPAT_HUMAN-Phosphoserine535 def: "Protein NPAT_HUMAN with the residue 535 substituted with Phosphoserine" [UniProtKB:Q14207] xref: UniProtKB:Q14207 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039946 ! NPAT_HUMAN [Term] id: CCO:B0039952 name: NPAT_HUMAN-Phosphoserine775 def: "Protein NPAT_HUMAN with the residue 775 substituted with Phosphoserine" [UniProtKB:Q14207] comment: by CDK2; xref: UniProtKB:Q14207 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039946 ! NPAT_HUMAN [Term] id: CCO:B0039953 name: NPAT_HUMAN-Phosphoserine779 def: "Protein NPAT_HUMAN with the residue 779 substituted with Phosphoserine" [UniProtKB:Q14207] comment: by CDK2; xref: UniProtKB:Q14207 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039946 ! NPAT_HUMAN [Term] id: CCO:B0039954 name: NPAT_HUMAN-Phosphoserine1100 def: "Protein NPAT_HUMAN with the residue 1100 substituted with Phosphoserine" [UniProtKB:Q14207] comment: by CDK2; xref: UniProtKB:Q14207 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039946 ! NPAT_HUMAN [Term] id: CCO:B0039955 name: NPAT_HUMAN-Phosphothreonine1270 def: "Protein NPAT_HUMAN with the residue 1270 substituted with Phosphothreonine" [UniProtKB:Q14207] comment: by CDK2; xref: UniProtKB:Q14207 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039946 ! NPAT_HUMAN [Term] id: CCO:B0039956 name: NPAT_HUMAN-Phosphothreonine1350 def: "Protein NPAT_HUMAN with the residue 1350 substituted with Phosphothreonine" [UniProtKB:Q14207] comment: by CDK2; xref: UniProtKB:Q14207 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039946 ! NPAT_HUMAN [Term] id: CCO:B0039979 name: PP16A_HUMAN def: "Protein phosphatase 1 regulatory subunit 16A" [UniProtKB:Q96I34] synonym: "Myosin phosphatase-targeting subunit 3" EXACT [UniProtKB:Q96I34] xref: EMBL:AAH07854.1 xref: EMBL:AAH49841.1 xref: EMBL:AAH53506.1 xref: EMBL:AAP35491.1 xref: EMBL:BAC03452.1 xref: UniProtKB:Q96I34 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0013022 ! PPP1R16A_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008654 ! ppp1r16a-fsd1 physical interaction relationship: transforms_into CCO:B0039988 ! PP16A_HUMAN-Phosphotyrosine434 [Term] id: CCO:B0039988 name: PP16A_HUMAN-Phosphotyrosine434 def: "Protein PP16A_HUMAN with the residue 434 substituted with Phosphotyrosine" [UniProtKB:Q96I34] comment: By similarity xref: UniProtKB:Q96I34 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0039979 ! PP16A_HUMAN [Term] id: CCO:B0040022 name: JMY_HUMAN def: "Junction-mediating and -regulatory protein" [UniProtKB:Q8N9B5] xref: EMBL:AAI30625.1 xref: EMBL:BAC04495.1 xref: EMBL:EAW95834.1 xref: UniProtKB:A1L4P5 xref: UniProtKB:Q8N9B5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0006025 ! JMY_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0007362 ! p53-jmy-1 physical interaction relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0040683 name: GABP1_HUMAN def: "GA-binding protein subunit beta-1" [UniProtKB:Q06547] synonym: "GABP subunit beta-1" EXACT [UniProtKB:Q06547] synonym: "GABP subunit beta-2" EXACT [UniProtKB:Q06547] synonym: "GABPB-1" EXACT [UniProtKB:Q06547] synonym: "GABPB-2" EXACT [UniProtKB:Q06547] synonym: "Nuclear respiratory factor 2" EXACT [UniProtKB:Q06547] synonym: "Transcription factor E4TF1-47" EXACT [UniProtKB:Q06547] synonym: "Transcription factor E4TF1-53" EXACT [UniProtKB:Q06547] xref: EMBL:AAA65707.1 xref: EMBL:AAA65708.1 xref: EMBL:AAA65709.1 xref: EMBL:AAA65710.1 xref: EMBL:AAH16910.1 xref: EMBL:AAH36080.1 xref: EMBL:AAH50702.1 xref: EMBL:AAP35298.1 xref: EMBL:BAA02573.1 xref: EMBL:BAA02574.1 xref: UniProtKB:Q06545 xref: UniProtKB:Q06547 xref: UniProtKB:Q12940 xref: UniProtKB:Q12941 xref: UniProtKB:Q12942 xref: UniProtKB:Q8IYD0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0013375 ! GABPB1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005768 ! fancg-gabpb2 physical interaction relationship: participates_in CCO:I0006868 ! hcfc1-gabp2b1-2 physical interaction relationship: participates_in CCO:I0007261 ! hcfc1-gabp2-3 physical interaction relationship: participates_in CCO:I0007263 ! hcfc1-gabp2-4 direct interaction [Term] id: CCO:B0040684 name: REBL1_HUMAN def: "GTPase RhebL1 precursor" [UniProtKB:Q8TAI7] synonym: "Ras homolog enriched in brain like-1 c" EXACT [UniProtKB:Q8TAI7] synonym: "Ras homolog enriched in brain-like protein 1" EXACT [UniProtKB:Q8TAI7] synonym: "Rheb-like protein 1" EXACT [UniProtKB:Q8TAI7] synonym: "Rheb2" EXACT [UniProtKB:Q8TAI7] synonym: "RhebL1c" EXACT [UniProtKB:Q8TAI7] xref: EMBL:AAH27482.1 xref: EMBL:AAP92804.1 xref: EMBL:AAS80166.1 xref: EMBL:BAC05370.1 xref: EMBL:EAW58038.1 xref: UniProtKB:Q56VH8 xref: UniProtKB:Q8TAI7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006028 ! RHEBL1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005791 ! rhebl1-txnl4a physical interaction relationship: transforms_into CCO:B0041177 ! REBL1_HUMAN-Cysteine methyl ester180 [Term] id: CCO:B0040685 name: ANR24_HUMAN def: "Ankyrin repeat domain-containing protein 24" [UniProtKB:Q8TF21] xref: EMBL:AAC33490.1 xref: EMBL:AAD15479.1 xref: EMBL:BAB85567.1 xref: UniProtKB:O75268 xref: UniProtKB:O95781 xref: UniProtKB:Q8TF21 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0006032 ! ANKRD24_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008064 ! ankrd24-rif1 physical interaction [Term] id: CCO:B0040686 name: NC2A_HUMAN def: "Dr1-associated corepressor" [UniProtKB:Q14919] synonym: "Dr1-associated protein 1" EXACT [UniProtKB:Q14919] synonym: "NC2-alpha" EXACT [UniProtKB:Q14919] synonym: "Negative co-factor 2-alpha" EXACT [UniProtKB:Q14919] xref: EMBL:AAB02192.1 xref: EMBL:AAH10025.1 xref: EMBL:CAA65358.1 xref: UniProtKB:Q13448 xref: UniProtKB:Q14919 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0004511 ! DRAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008083 ! cdkn2c-drap1 physical interaction [Term] id: CCO:B0040687 name: CUX1_HUMAN def: "Homeobox protein cut-like 1" [UniProtKB:P39880] synonym: "CCAAT displacement protein" EXACT [UniProtKB:P39880] synonym: "CDP" EXACT [UniProtKB:P39880] xref: EMBL:AAC78778.1 xref: EMBL:AAH66592.1 xref: UniProtKB:P39880 xref: UniProtKB:Q6NYH4 xref: UniProtKB:Q9UEV5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0013373 ! CUX1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008379 ! cutl1-bin1 physical interaction relationship: transforms_into CCO:B0041130 ! CUX1_HUMAN-Phosphoserine322 relationship: transforms_into CCO:B0041131 ! CUX1_HUMAN-Phosphoserine1218 relationship: transforms_into CCO:B0041132 ! CUX1_HUMAN-Phosphotyrosine1232 relationship: transforms_into CCO:B0041133 ! CUX1_HUMAN-Phosphoserine1233 relationship: transforms_into CCO:B0041134 ! CUX1_HUMAN-Phosphoserine1312 [Term] id: CCO:B0040688 name: RPN1_HUMAN def: "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor" [UniProtKB:P04843] synonym: "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit" EXACT [UniProtKB:P04843] synonym: "EC 2.4.1.119" EXACT [UniProtKB:P04843] synonym: "Ribophorin I" EXACT [UniProtKB:P04843] synonym: "Ribophorin-1" EXACT [UniProtKB:P04843] synonym: "RPN-I" EXACT [UniProtKB:P04843] xref: EMBL:AAH10839.1 xref: EMBL:CAA68392.1 xref: EMBL:CAH18139.1 xref: UniProtKB:P04843 xref: UniProtKB:Q68DT1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005487 ! RPN1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008502 ! rpn1-rbbp4 physical interaction [Term] id: CCO:B0041106 name: 1433T_HUMAN-N-acetylmethionine1 def: "Protein 1433T_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P27348] xref: UniProtKB:P27348 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001559 ! 1433T_HUMAN [Term] id: CCO:B0041107 name: 4ET_HUMAN-Phosphoserine914 def: "Protein 4ET_HUMAN with the residue 914 substituted with Phosphoserine" [UniProtKB:Q9NRA8] xref: UniProtKB:Q9NRA8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006012 ! 4ET_HUMAN [Term] id: CCO:B0041108 name: 4ET_HUMAN-Phosphoserine920 def: "Protein 4ET_HUMAN with the residue 920 substituted with Phosphoserine" [UniProtKB:Q9NRA8] xref: UniProtKB:Q9NRA8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006012 ! 4ET_HUMAN [Term] id: CCO:B0041109 name: ACTB_HUMAN-Phosphothreonine318 def: "Protein ACTB_HUMAN with the residue 318 substituted with Phosphothreonine" [UniProtKB:P60709] xref: UniProtKB:P60709 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005775 ! ACTB_HUMAN [Term] id: CCO:B0041110 name: ANM5_HUMAN-N-acetylalanine2 def: "Protein ANM5_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:O14744] xref: UniProtKB:O14744 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001357 ! ANM5_HUMAN [Term] id: CCO:B0041111 name: APC1_HUMAN-Phosphoserine202 def: "Protein APC1_HUMAN with the residue 202 substituted with Phosphoserine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041112 name: APC1_HUMAN-Phosphoserine286 def: "Protein APC1_HUMAN with the residue 286 substituted with Phosphoserine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041113 name: APC1_HUMAN-Phosphothreonine291 def: "Protein APC1_HUMAN with the residue 291 substituted with Phosphothreonine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041114 name: APC1_HUMAN-Phosphoserine355 def: "Protein APC1_HUMAN with the residue 355 substituted with Phosphoserine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041115 name: APC1_HUMAN-Phosphoserine373 def: "Protein APC1_HUMAN with the residue 373 substituted with Phosphoserine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041116 name: APC1_HUMAN-Phosphoserine377 def: "Protein APC1_HUMAN with the residue 377 substituted with Phosphoserine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041117 name: APC1_HUMAN-Phosphothreonine537 def: "Protein APC1_HUMAN with the residue 537 substituted with Phosphothreonine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041118 name: APC1_HUMAN-Phosphotyrosine571 def: "Protein APC1_HUMAN with the residue 571 substituted with Phosphotyrosine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041119 name: APC1_HUMAN-Phosphoserine686 def: "Protein APC1_HUMAN with the residue 686 substituted with Phosphoserine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041120 name: APC1_HUMAN-Phosphoserine688 def: "Protein APC1_HUMAN with the residue 688 substituted with Phosphoserine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041121 name: APC1_HUMAN-Phosphoserine731 def: "Protein APC1_HUMAN with the residue 731 substituted with Phosphoserine" [UniProtKB:Q9H1A4] xref: UniProtKB:Q9H1A4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002125 ! APC1_HUMAN [Term] id: CCO:B0041122 name: APC4_HUMAN-Phosphotyrosine469 def: "Protein APC4_HUMAN with the residue 469 substituted with Phosphotyrosine" [UniProtKB:Q9UJX5] xref: UniProtKB:Q9UJX5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002215 ! APC4_HUMAN [Term] id: CCO:B0041123 name: APC4_HUMAN-Phosphoserine779 def: "Protein APC4_HUMAN with the residue 779 substituted with Phosphoserine" [UniProtKB:Q9UJX5] xref: UniProtKB:Q9UJX5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002215 ! APC4_HUMAN [Term] id: CCO:B0041124 name: APC5_HUMAN-Phosphoserine195 def: "Protein APC5_HUMAN with the residue 195 substituted with Phosphoserine" [UniProtKB:Q9UJX4] xref: UniProtKB:Q9UJX4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002214 ! APC5_HUMAN [Term] id: CCO:B0041125 name: APC5_HUMAN-Phosphoserine217 def: "Protein APC5_HUMAN with the residue 217 substituted with Phosphoserine" [UniProtKB:Q9UJX4] xref: UniProtKB:Q9UJX4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002214 ! APC5_HUMAN [Term] id: CCO:B0041126 name: BCL3_HUMAN-Phosphoserine394 def: "Protein BCL3_HUMAN with the residue 394 substituted with Phosphoserine" [UniProtKB:P20749] comment: by GSK3; xref: UniProtKB:P20749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005513 ! BCL3_HUMAN [Term] id: CCO:B0041127 name: BCL3_HUMAN-Phosphoserine398 def: "Protein BCL3_HUMAN with the residue 398 substituted with Phosphoserine" [UniProtKB:P20749] comment: by GSK3; xref: UniProtKB:P20749 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005513 ! BCL3_HUMAN [Term] id: CCO:B0041128 name: CD2AP_HUMAN-Phosphoserine458 def: "Protein CD2AP_HUMAN with the residue 458 substituted with Phosphoserine" [UniProtKB:Q9Y5K6] xref: UniProtKB:Q9Y5K6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002257 ! CD2AP_HUMAN [Term] id: CCO:B0041129 name: CND3_HUMAN-Phosphothreonine686 def: "Protein CND3_HUMAN with the residue 686 substituted with Phosphothreonine" [UniProtKB:Q9BPX3] xref: UniProtKB:Q9BPX3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002092 ! CND3_HUMAN [Term] id: CCO:B0041130 name: CUX1_HUMAN-Phosphoserine322 def: "Protein CUX1_HUMAN with the residue 322 substituted with Phosphoserine" [UniProtKB:P39880] xref: UniProtKB:P39880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0040687 ! CUX1_HUMAN [Term] id: CCO:B0041131 name: CUX1_HUMAN-Phosphoserine1218 def: "Protein CUX1_HUMAN with the residue 1218 substituted with Phosphoserine" [UniProtKB:P39880] xref: UniProtKB:P39880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0040687 ! CUX1_HUMAN [Term] id: CCO:B0041132 name: CUX1_HUMAN-Phosphotyrosine1232 def: "Protein CUX1_HUMAN with the residue 1232 substituted with Phosphotyrosine" [UniProtKB:P39880] xref: UniProtKB:P39880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0040687 ! CUX1_HUMAN [Term] id: CCO:B0041133 name: CUX1_HUMAN-Phosphoserine1233 def: "Protein CUX1_HUMAN with the residue 1233 substituted with Phosphoserine" [UniProtKB:P39880] xref: UniProtKB:P39880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0040687 ! CUX1_HUMAN [Term] id: CCO:B0041134 name: CUX1_HUMAN-Phosphoserine1312 def: "Protein CUX1_HUMAN with the residue 1312 substituted with Phosphoserine" [UniProtKB:P39880] xref: UniProtKB:P39880 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0040687 ! CUX1_HUMAN [Term] id: CCO:B0041135 name: EP15_HUMAN-Phosphothreonine777 def: "Protein EP15_HUMAN with the residue 777 substituted with Phosphothreonine" [UniProtKB:P42566] xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0041136 name: EP15_HUMAN-Phosphoserine796 def: "Protein EP15_HUMAN with the residue 796 substituted with Phosphoserine" [UniProtKB:P42566] xref: UniProtKB:P42566 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:B0041137 name: GA2L1_HUMAN-Phosphoserine306 def: "Protein GA2L1_HUMAN with the residue 306 substituted with Phosphoserine" [UniProtKB:Q99501] xref: UniProtKB:Q99501 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002067 ! GA2L1_HUMAN [Term] id: CCO:B0041138 name: GA2L1_HUMAN-Phosphoserine352 def: "Protein GA2L1_HUMAN with the residue 352 substituted with Phosphoserine" [UniProtKB:Q99501] xref: UniProtKB:Q99501 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002067 ! GA2L1_HUMAN [Term] id: CCO:B0041143 name: HD_HUMAN-Phosphoserine434 def: "Protein HD_HUMAN with the residue 434 substituted with Phosphoserine" [UniProtKB:P42858] xref: UniProtKB:P42858 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005407 ! HD_HUMAN [Term] id: CCO:B0041144 name: HNRPC_HUMAN-N-acetylalanine2 def: "Protein HNRPC_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P07910] xref: UniProtKB:P07910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:B0041145 name: IKBA_HUMAN-Phosphoserine283 def: "Protein IKBA_HUMAN with the residue 283 substituted with Phosphoserine" [UniProtKB:P25963] comment: by CK2; xref: UniProtKB:P25963 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:B0041146 name: IKBA_HUMAN-Phosphoserine288 def: "Protein IKBA_HUMAN with the residue 288 substituted with Phosphoserine" [UniProtKB:P25963] comment: by CK2; xref: UniProtKB:P25963 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:B0041147 name: IKBA_HUMAN-Phosphothreonine291 def: "Protein IKBA_HUMAN with the residue 291 substituted with Phosphothreonine" [UniProtKB:P25963] comment: by CK2; xref: UniProtKB:P25963 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:B0041148 name: IKBA_HUMAN-Phosphoserine293 def: "Protein IKBA_HUMAN with the residue 293 substituted with Phosphoserine" [UniProtKB:P25963] comment: by CK2; xref: UniProtKB:P25963 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:B0041149 name: IKBA_HUMAN-Phosphothreonine299 def: "Protein IKBA_HUMAN with the residue 299 substituted with Phosphothreonine" [UniProtKB:P25963] comment: by CK2; xref: UniProtKB:P25963 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:B0041150 name: IKBB_HUMAN-Phosphoserine313 def: "Protein IKBB_HUMAN with the residue 313 substituted with Phosphoserine" [UniProtKB:Q15653] comment: by CK2; xref: UniProtKB:Q15653 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005537 ! IKBB_HUMAN [Term] id: CCO:B0041151 name: IKBB_HUMAN-Phosphoserine315 def: "Protein IKBB_HUMAN with the residue 315 substituted with Phosphoserine" [UniProtKB:Q15653] comment: by CK2; xref: UniProtKB:Q15653 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005537 ! IKBB_HUMAN [Term] id: CCO:B0041152 name: IKKB_HUMAN-S-nitrosocysteine179 def: "Protein IKKB_HUMAN with the residue 179 substituted with S-nitrosocysteine" [UniProtKB:O14920] xref: UniProtKB:O14920 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:B0041153 name: INOC1_HUMAN-Phosphothreonine1550 def: "Protein INOC1_HUMAN with the residue 1550 substituted with Phosphothreonine" [UniProtKB:Q9ULG1] xref: UniProtKB:Q9ULG1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006056 ! INOC1_HUMAN [Term] id: CCO:B0041154 name: KHDR1_HUMAN-Phosphoserine113 def: "Protein KHDR1_HUMAN with the residue 113 substituted with Phosphoserine" [UniProtKB:Q07666] comment: By similarity xref: UniProtKB:Q07666 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:B0041155 name: KI13B_HUMAN-Phosphoserine1644 def: "Protein KI13B_HUMAN with the residue 1644 substituted with Phosphoserine" [UniProtKB:Q9NQT8] xref: UniProtKB:Q9NQT8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005849 ! KI13B_HUMAN [Term] id: CCO:B0041156 name: LIS1_HUMAN-Phosphotyrosine225 def: "Protein LIS1_HUMAN with the residue 225 substituted with Phosphotyrosine" [UniProtKB:P43034] xref: UniProtKB:P43034 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001618 ! LIS1_HUMAN [Term] id: CCO:B0041158 name: M4K2_HUMAN-Phosphoserine393 def: "Protein M4K2_HUMAN with the residue 393 substituted with Phosphoserine" [UniProtKB:Q12851] xref: UniProtKB:Q12851 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005706 ! M4K2_HUMAN [Term] id: CCO:B0041159 name: MD2L1_HUMAN-N-acetylalanine2 def: "Protein MD2L1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q13257] xref: UniProtKB:Q13257 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001748 ! MD2L1_HUMAN [Term] id: CCO:B0041160 name: MK13_HUMAN-Phosphoserine47 def: "Protein MK13_HUMAN with the residue 47 substituted with Phosphoserine" [UniProtKB:O15264] xref: UniProtKB:O15264 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001369 ! MK13_HUMAN [Term] id: CCO:B0041161 name: MTSS1_HUMAN-Phosphoserine261 def: "Protein MTSS1_HUMAN with the residue 261 substituted with Phosphoserine" [UniProtKB:O43312] xref: UniProtKB:O43312 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001390 ! MTSS1_HUMAN [Term] id: CCO:B0041162 name: MYH9_HUMAN-Phosphoserine1714 def: "Protein MYH9_HUMAN with the residue 1714 substituted with Phosphoserine" [UniProtKB:P35579] xref: UniProtKB:P35579 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0019193 ! MYH9_HUMAN [Term] id: CCO:B0041163 name: NEMO_HUMAN-Phosphoserine31 def: "Protein NEMO_HUMAN with the residue 31 substituted with Phosphoserine" [UniProtKB:Q9Y6K9] comment: by IKKB; xref: UniProtKB:Q9Y6K9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:B0041164 name: NEMO_HUMAN-Phosphoserine43 def: "Protein NEMO_HUMAN with the residue 43 substituted with Phosphoserine" [UniProtKB:Q9Y6K9] comment: by IKKB; xref: UniProtKB:Q9Y6K9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:B0041165 name: NEMO_HUMAN-Phosphoserine68 def: "Protein NEMO_HUMAN with the residue 68 substituted with Phosphoserine" [UniProtKB:Q9Y6K9] xref: UniProtKB:Q9Y6K9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:B0041166 name: NEMO_HUMAN-Phosphoserine85 def: "Protein NEMO_HUMAN with the residue 85 substituted with Phosphoserine" [UniProtKB:Q9Y6K9] comment: by ATM; xref: UniProtKB:Q9Y6K9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:B0041167 name: NEMO_HUMAN-Phosphoserine376 def: "Protein NEMO_HUMAN with the residue 376 substituted with Phosphoserine" [UniProtKB:Q9Y6K9] comment: by IKKB; xref: UniProtKB:Q9Y6K9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:B0041168 name: OGT1_HUMAN-N-acetylalanine2 def: "Protein OGT1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:O15294] xref: UniProtKB:O15294 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005806 ! OGT1_HUMAN [Term] id: CCO:B0041169 name: P53_HUMAN-Phosphoserine9 def: "Protein P53_HUMAN with the residue 9 substituted with Phosphoserine" [UniProtKB:P04637] comment: by HIPK4; xref: UniProtKB:P04637 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001483 ! P53_HUMAN [Term] id: CCO:B0041170 name: PARD3_HUMAN-Phosphoserine852 def: "Protein PARD3_HUMAN with the residue 852 substituted with Phosphoserine" [UniProtKB:Q8TEW0] xref: UniProtKB:Q8TEW0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001996 ! PARD3_HUMAN [Term] id: CCO:B0041171 name: PCAF_HUMAN-Phosphoserine40 def: "Protein PCAF_HUMAN with the residue 40 substituted with Phosphoserine" [UniProtKB:Q92831] comment: By similarity xref: UniProtKB:Q92831 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002019 ! PCAF_HUMAN [Term] id: CCO:B0041172 name: PP1A_HUMAN-Phosphothreonine320 def: "Protein PP1A_HUMAN with the residue 320 substituted with Phosphothreonine" [UniProtKB:P62136] xref: UniProtKB:P62136 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001086 ! phosphoprotein phosphatase activity relationship: has_function CCO:F0001087 ! protein serine/threonine phosphatase activity relationship: has_function CCO:F0001643 ! iron ion binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0004328 ! manganese ion binding relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: transformation_of CCO:B0001688 ! PP1A_HUMAN [Term] id: CCO:B0041173 name: RASH_HUMAN-N-acetylmethionine1 def: "Protein RASH_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P01112] comment: alternate; xref: UniProtKB:P01112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001467 ! RASH_HUMAN [Term] id: CCO:B0041174 name: RASH_HUMAN-N-acetylthreonine2 def: "Protein RASH_HUMAN with the residue 2 substituted with N-acetylthreonine" [UniProtKB:P01112] xref: UniProtKB:P01112 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001467 ! RASH_HUMAN [Term] id: CCO:B0041175 name: RASK_HUMAN-N-acetylmethionine1 def: "Protein RASK_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P01116] comment: alternate; xref: UniProtKB:P01116 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001468 ! RASK_HUMAN [Term] id: CCO:B0041176 name: RASK_HUMAN-N-acetylthreonine2 def: "Protein RASK_HUMAN with the residue 2 substituted with N-acetylthreonine" [UniProtKB:P01116] xref: UniProtKB:P01116 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001468 ! RASK_HUMAN [Term] id: CCO:B0041177 name: REBL1_HUMAN-Cysteine methyl ester180 def: "Protein REBL1_HUMAN with the residue 180 substituted with Cysteine methyl ester" [UniProtKB:Q8TAI7] comment: By similarity xref: UniProtKB:Q8TAI7 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0040684 ! REBL1_HUMAN [Term] id: CCO:B0041178 name: RELB_HUMAN-Phosphothreonine103 def: "Protein RELB_HUMAN with the residue 103 substituted with Phosphothreonine" [UniProtKB:Q01201] comment: By similarity xref: UniProtKB:Q01201 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005529 ! RELB_HUMAN [Term] id: CCO:B0041179 name: RELB_HUMAN-Phosphoserine573 def: "Protein RELB_HUMAN with the residue 573 substituted with Phosphoserine" [UniProtKB:Q01201] comment: By similarity xref: UniProtKB:Q01201 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005529 ! RELB_HUMAN [Term] id: CCO:B0041180 name: S10A9_HUMAN-Blocked amino end (Thr)2 def: "Protein S10A9_HUMAN with the residue 2 substituted with Blocked amino end (Thr)" [UniProtKB:P06702] xref: UniProtKB:P06702 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005461 ! S10A9_HUMAN [Term] id: CCO:B0041181 name: SCG1_HUMAN-Phosphothreonine79 def: "Protein SCG1_HUMAN with the residue 79 substituted with Phosphothreonine" [UniProtKB:P05060] comment: Probable xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041182 name: SCG1_HUMAN-Phosphoserine99 def: "Protein SCG1_HUMAN with the residue 99 substituted with Phosphoserine" [UniProtKB:P05060] comment: Potential xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041183 name: SCG1_HUMAN-Phosphoserine100 def: "Protein SCG1_HUMAN with the residue 100 substituted with Phosphoserine" [UniProtKB:P05060] comment: Potential xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041184 name: SCG1_HUMAN-Phosphoserine293 def: "Protein SCG1_HUMAN with the residue 293 substituted with Phosphoserine" [UniProtKB:P05060] comment: Potential xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041185 name: SCG1_HUMAN-Phosphoserine294 def: "Protein SCG1_HUMAN with the residue 294 substituted with Phosphoserine" [UniProtKB:P05060] comment: Potential xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041186 name: SCG1_HUMAN-Phosphoserine380 def: "Protein SCG1_HUMAN with the residue 380 substituted with Phosphoserine" [UniProtKB:P05060] xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041187 name: SCG1_HUMAN-Sulfotyrosine471 def: "Protein SCG1_HUMAN with the residue 471 substituted with Sulfotyrosine" [UniProtKB:P05060] comment: Potential xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041188 name: SCG1_HUMAN-Sulfotyrosine474 def: "Protein SCG1_HUMAN with the residue 474 substituted with Sulfotyrosine" [UniProtKB:P05060] comment: Probable xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041189 name: SCG1_HUMAN-Phosphoserine533 def: "Protein SCG1_HUMAN with the residue 533 substituted with Phosphoserine" [UniProtKB:P05060] comment: Potential xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041190 name: SCG1_HUMAN-Phosphoserine534 def: "Protein SCG1_HUMAN with the residue 534 substituted with Phosphoserine" [UniProtKB:P05060] comment: Potential xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041191 name: SCG1_HUMAN-Sulfotyrosine566 def: "Protein SCG1_HUMAN with the residue 566 substituted with Sulfotyrosine" [UniProtKB:P05060] comment: Probable xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041192 name: SCG1_HUMAN-Sulfotyrosine568 def: "Protein SCG1_HUMAN with the residue 568 substituted with Sulfotyrosine" [UniProtKB:P05060] comment: Potential xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041193 name: SCG1_HUMAN-Phosphoserine631 def: "Protein SCG1_HUMAN with the residue 631 substituted with Phosphoserine" [UniProtKB:P05060] comment: By similarity xref: UniProtKB:P05060 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:B0041194 name: SEPT5_HUMAN-Phosphoserine225 def: "Protein SEPT5_HUMAN with the residue 225 substituted with Phosphoserine" [UniProtKB:Q99719] xref: UniProtKB:Q99719 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000427 ! GTPase activity relationship: has_function CCO:F0001484 ! structural molecule activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000444 ! plasma membrane relationship: located_in CCO:C0000522 ! synaptic vesicle relationship: located_in CCO:C0001135 ! septin complex relationship: transformation_of CCO:B0002085 ! SEPT5_HUMAN [Term] id: CCO:B0041195 name: SIRT2_HUMAN-Phosphoserine25 def: "Protein SIRT2_HUMAN with the residue 25 substituted with Phosphoserine" [UniProtKB:Q8IXJ6] xref: UniProtKB:Q8IXJ6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001951 ! SIRT2_HUMAN [Term] id: CCO:B0041196 name: SIRT2_HUMAN-Phosphoserine27 def: "Protein SIRT2_HUMAN with the residue 27 substituted with Phosphoserine" [UniProtKB:Q8IXJ6] xref: UniProtKB:Q8IXJ6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001951 ! SIRT2_HUMAN [Term] id: CCO:B0041197 name: SPTB2_HUMAN-Phosphoserine2164 def: "Protein SPTB2_HUMAN with the residue 2164 substituted with Phosphoserine" [UniProtKB:Q01082] xref: UniProtKB:Q01082 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:B0041198 name: SRC_HUMAN-Phosphothreonine74 def: "Protein SRC_HUMAN with the residue 74 substituted with Phosphothreonine" [UniProtKB:P12931] xref: UniProtKB:P12931 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005464 ! SRC_HUMAN [Term] id: CCO:B0041199 name: STK6_HUMAN-Phosphothreonine287 def: "Protein STK6_HUMAN with the residue 287 substituted with Phosphothreonine" [UniProtKB:O14965] xref: UniProtKB:O14965 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001363 ! STK6_HUMAN [Term] id: CCO:B0041200 name: STK6_HUMAN-Phosphothreonine288 def: "Protein STK6_HUMAN with the residue 288 substituted with Phosphothreonine" [UniProtKB:O14965] xref: UniProtKB:O14965 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001363 ! STK6_HUMAN [Term] id: CCO:B0041201 name: T22D4_HUMAN-Phosphoserine62 def: "Protein T22D4_HUMAN with the residue 62 substituted with Phosphoserine" [UniProtKB:Q9Y3Q8] xref: UniProtKB:Q9Y3Q8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:B0041202 name: T22D4_HUMAN-Phosphoserine165 def: "Protein T22D4_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:Q9Y3Q8] xref: UniProtKB:Q9Y3Q8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:B0041203 name: T22D4_HUMAN-Phosphothreonine211 def: "Protein T22D4_HUMAN with the residue 211 substituted with Phosphothreonine" [UniProtKB:Q9Y3Q8] xref: UniProtKB:Q9Y3Q8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:B0041204 name: T22D4_HUMAN-Phosphoserine279 def: "Protein T22D4_HUMAN with the residue 279 substituted with Phosphoserine" [UniProtKB:Q9Y3Q8] xref: UniProtKB:Q9Y3Q8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:B0041205 name: TBA4A_HUMAN-Phosphoserine439 def: "Protein TBA4A_HUMAN with the residue 439 substituted with Phosphoserine" [UniProtKB:P68366] xref: UniProtKB:P68366 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005449 ! TBA4A_HUMAN [Term] id: CCO:B0041206 name: TBA4A_HUMAN-Phosphotyrosine440 def: "Protein TBA4A_HUMAN with the residue 440 substituted with Phosphotyrosine" [UniProtKB:P68366] xref: UniProtKB:P68366 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005449 ! TBA4A_HUMAN [Term] id: CCO:B0041207 name: TF65_HUMAN-N6-acetyllysine122 def: "Protein TF65_HUMAN with the residue 122 substituted with N6-acetyllysine" [UniProtKB:Q04206] comment: by PCAF and EP300; xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041208 name: TF65_HUMAN-N6-acetyllysine123 def: "Protein TF65_HUMAN with the residue 123 substituted with N6-acetyllysine" [UniProtKB:Q04206] comment: by PCAF and EP300; xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041209 name: TF65_HUMAN-Phosphothreonine254 def: "Protein TF65_HUMAN with the residue 254 substituted with Phosphothreonine" [UniProtKB:Q04206] xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041210 name: TF65_HUMAN-Phosphoserine281 def: "Protein TF65_HUMAN with the residue 281 substituted with Phosphoserine" [UniProtKB:Q04206] comment: Probable xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041211 name: TF65_HUMAN-N6-acetyllysine310 def: "Protein TF65_HUMAN with the residue 310 substituted with N6-acetyllysine" [UniProtKB:Q04206] xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041212 name: TF65_HUMAN-Phosphoserine311 def: "Protein TF65_HUMAN with the residue 311 substituted with Phosphoserine" [UniProtKB:Q04206] comment: by PKC/PRKCZ; By similarity xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041213 name: TF65_HUMAN-Phosphothreonine435 def: "Protein TF65_HUMAN with the residue 435 substituted with Phosphothreonine" [UniProtKB:Q04206] xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041214 name: TF65_HUMAN-Phosphoserine468 def: "Protein TF65_HUMAN with the residue 468 substituted with Phosphoserine" [UniProtKB:Q04206] comment: by IKKB and IKKE; xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041215 name: TF65_HUMAN-Phosphothreonine505 def: "Protein TF65_HUMAN with the residue 505 substituted with Phosphothreonine" [UniProtKB:Q04206] comment: by CHK1; xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041216 name: TF65_HUMAN-Phosphoserine529 def: "Protein TF65_HUMAN with the residue 529 substituted with Phosphoserine" [UniProtKB:Q04206] comment: by CK2; xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041217 name: TF65_HUMAN-Phosphoserine536 def: "Protein TF65_HUMAN with the residue 536 substituted with Phosphoserine" [UniProtKB:Q04206] comment: by IKKB; xref: UniProtKB:Q04206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:B0041218 name: TNIK_HUMAN-Phosphothreonine581 def: "Protein TNIK_HUMAN with the residue 581 substituted with Phosphothreonine" [UniProtKB:Q9UKE5] xref: UniProtKB:Q9UKE5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005603 ! TNIK_HUMAN [Term] id: CCO:B0041219 name: TNIK_HUMAN-Phosphoserine640 def: "Protein TNIK_HUMAN with the residue 640 substituted with Phosphoserine" [UniProtKB:Q9UKE5] xref: UniProtKB:Q9UKE5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005603 ! TNIK_HUMAN [Term] id: CCO:B0041220 name: TNIK_HUMAN-Phosphothreonine677 def: "Protein TNIK_HUMAN with the residue 677 substituted with Phosphothreonine" [UniProtKB:Q9UKE5] xref: UniProtKB:Q9UKE5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005603 ! TNIK_HUMAN [Term] id: CCO:B0041221 name: TXD11_HUMAN-Phosphoserine828 def: "Protein TXD11_HUMAN with the residue 828 substituted with Phosphoserine" [UniProtKB:Q6PKC3] xref: UniProtKB:Q6PKC3 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005993 ! TXD11_HUMAN [Term] id: CCO:B0041222 name: ZN363_HUMAN-Phosphoserine257 def: "Protein ZN363_HUMAN with the residue 257 substituted with Phosphoserine" [UniProtKB:Q96PM5] xref: UniProtKB:Q96PM5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005980 ! ZN363_HUMAN [Term] id: CCO:B0041223 name: ZYX_HUMAN-N-acetylalanine2 def: "Protein ZYX_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q15942] xref: UniProtKB:Q15942 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:B0041227 name: B1AHR1_HUMAN def: "Septin 3" [UniProtKB:B1AHR1] xref: EMBL:CAQ07553.1 xref: UniProtKB:B1AHR1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005586 ! SEPT3_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0041228 name: B1AK43_HUMAN def: "MAD2 mitotic arrest deficient-like 2" [UniProtKB:B1AK43] synonym: "Yeast" EXACT [UniProtKB:B1AK43] xref: EMBL:CAI20216.1 xref: UniProtKB:B1AK43 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005049 ! MAD2L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0041229 name: B1AK44_HUMAN def: "MAD2 mitotic arrest deficient-like 2" [UniProtKB:B1AK44] synonym: "Yeast" EXACT [UniProtKB:B1AK44] xref: EMBL:CAI20217.1 xref: UniProtKB:B1AK44 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005049 ! MAD2L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0041230 name: B1AK45_HUMAN def: "MAD2 mitotic arrest deficient-like 2" [UniProtKB:B1AK45] synonym: "Yeast" EXACT [UniProtKB:B1AK45] xref: EMBL:CAI20219.1 xref: UniProtKB:B1AK45 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005049 ! MAD2L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0041231 name: B1AK46_HUMAN def: "MAD2 mitotic arrest deficient-like 2" [UniProtKB:B1AK46] synonym: "Yeast" EXACT [UniProtKB:B1AK46] xref: EMBL:CAI20220.1 xref: UniProtKB:B1AK46 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005049 ! MAD2L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0041232 name: B1AK47_HUMAN def: "MAD2 mitotic arrest deficient-like 2" [UniProtKB:B1AK47] synonym: "Yeast" EXACT [UniProtKB:B1AK47] xref: EMBL:CAI20221.1 xref: UniProtKB:B1AK47 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005049 ! MAD2L2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0041233 name: B1ALC7_HUMAN def: "Microtubule-actin crosslinking factor 1" [UniProtKB:B1ALC7] xref: EMBL:CAI21818.1 xref: UniProtKB:B1ALC7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005012 ! MACF1_human relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0041234 name: B1AMS2_HUMAN def: "Septin 6" [UniProtKB:B1AMS2] synonym: "Septin 6, isoform CRA_b" EXACT [UniProtKB:B1AMS2] xref: EMBL:CAI41427.1 xref: EMBL:EAW89852.1 xref: UniProtKB:B1AMS2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005589 ! SEPT6_human relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0001135 ! septin complex relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0041235 name: B1ANQ7_HUMAN def: "Microtubule-actin crosslinking factor 1" [UniProtKB:B1ANQ7] xref: EMBL:CAI16411.1 xref: UniProtKB:B1ANQ7 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005012 ! MACF1_human relationship: has_function CCO:F0001645 ! calcium ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0041236 name: B1ANR2_HUMAN def: "Microtubule-actin crosslinking factor 1" [UniProtKB:B1ANR2] xref: EMBL:CAI16416.1 xref: UniProtKB:B1ANR2 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005012 ! MACF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0041237 name: B1AQT3_HUMAN def: "NUF2, NDC80 kinetochore complex component, homolog" [UniProtKB:B1AQT3] synonym: "S. cerevisiae" EXACT [UniProtKB:B1AQT3] xref: EMBL:CAI16704.1 xref: UniProtKB:B1AQT3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005224 ! NUF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0041238 name: B1AQT4_HUMAN def: "NUF2, NDC80 kinetochore complex component, homolog" [UniProtKB:B1AQT4] synonym: "S. cerevisiae" EXACT [UniProtKB:B1AQT4] xref: EMBL:CAI16705.1 xref: UniProtKB:B1AQT4 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0005224 ! NUF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000102 ! chromosome, pericentric region relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0041239 name: PSMD9_HUMAN def: "26S proteasome non-ATPase regulatory subunit 9" [UniProtKB:O00233] synonym: "26S proteasome regulatory subunit p27" EXACT [UniProtKB:O00233] xref: EMBL:AAH02383.1 xref: EMBL:AAH04184.1 xref: EMBL:AAH04213.1 xref: EMBL:BAA19790.1 xref: UniProtKB:O00233 xref: UniProtKB:Q9BQ42 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013405 ! PSMD9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008691 ! psmc6-psmd9 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041336 ! PSMD9_HUMAN-Phosphoserine129 [Term] id: CCO:B0041240 name: PSD10_HUMAN def: "26S proteasome non-ATPase regulatory subunit 10" [UniProtKB:O75832] synonym: "26S proteasome regulatory subunit p28" EXACT [UniProtKB:O75832] synonym: "Gankyrin" EXACT [UniProtKB:O75832] xref: EMBL:AAH11960.1 xref: EMBL:BAA33215.1 xref: EMBL:BAA34594.1 xref: EMBL:CAA20117.1 xref: UniProtKB:O75832 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013402 ! PSMD10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008699 ! psmc4-psmd10 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041328 ! PSD10_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0041241 name: CCDB1_HUMAN def: "Cyclin-D1-binding protein 1" [UniProtKB:O95273] synonym: "Grap2 and cyclin-D-interacting protein" EXACT [UniProtKB:O95273] synonym: "Human homolog of Maid" EXACT [UniProtKB:O95273] xref: EMBL:AAD11777.1 xref: EMBL:AAF14872.1 xref: EMBL:AAF67182.1 xref: EMBL:AAF77613.1 xref: EMBL:AAH09689.1 xref: EMBL:AAP97163.1 xref: EMBL:BAC11433.1 xref: EMBL:BAC11530.1 xref: EMBL:BAC87645.1 xref: EMBL:BAF83354.1 xref: EMBL:BAF83396.1 xref: EMBL:CAG29327.1 xref: EMBL:EAW92588.1 xref: EMBL:EAW92590.1 xref: UniProtKB:A8K3Q0 xref: UniProtKB:A8K3U2 xref: UniProtKB:O95273 xref: UniProtKB:Q6ZQN9 xref: UniProtKB:Q7Z519 xref: UniProtKB:Q8NBS7 xref: UniProtKB:Q8NBY2 xref: UniProtKB:Q9NS19 xref: UniProtKB:Q9NYH3 xref: UniProtKB:Q9UHX9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013383 ! CCNDBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008821 ! mrps9-ccndbp1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0041242 name: PRS6A_HUMAN def: "26S protease regulatory subunit 6A" [UniProtKB:P17980] synonym: "Proteasome 26S subunit ATPase 3" EXACT [UniProtKB:P17980] synonym: "Proteasome subunit P50" EXACT [UniProtKB:P17980] synonym: "Tat-binding protein 1" EXACT [UniProtKB:P17980] synonym: "TBP-1" EXACT [UniProtKB:P17980] xref: EMBL:AAA36666.1 xref: EMBL:AAH08713.4 xref: EMBL:AAH73165.3 xref: EMBL:AAI06921.1 xref: EMBL:AAI07805.1 xref: EMBL:BAD96205.1 xref: EMBL:CAG33012.1 xref: UniProtKB:P17980 xref: UniProtKB:Q3B757 xref: UniProtKB:Q3B865 xref: UniProtKB:Q53HU5 xref: UniProtKB:Q6GPG8 xref: UniProtKB:Q6IBS1 xref: UniProtKB:Q96HD3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013394 ! PSMC3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008716 ! traf6-psmc3 physical interaction relationship: participates_in CCO:I0008785 ! atxn1-psmc3 physical interaction relationship: participates_in CCO:I0008811 ! stx11-psmc3 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041314 ! PRS6A_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0041315 ! PRS6A_HUMAN-Phosphoserine9 [Term] id: CCO:B0041243 name: PSA2_HUMAN def: "Proteasome subunit alpha type-2" [UniProtKB:P25787] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P25787] synonym: "Macropain subunit C3" EXACT [UniProtKB:P25787] synonym: "Multicatalytic endopeptidase complex subunit C3" EXACT [UniProtKB:P25787] synonym: "Proteasome component C3" EXACT [UniProtKB:P25787] xref: EMBL:AAH02900.2 xref: EMBL:AAH47697.1 xref: EMBL:BAA00657.1 xref: UniProtKB:P25787 xref: UniProtKB:Q9BU45 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013398 ! PSMA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008724 ! alpha1-alpha2 physical interaction relationship: participates_in CCO:I0008728 ! alpha2-alpha1 physical interaction relationship: participates_in CCO:I0008729 ! alpha2-alpha4 physical interaction relationship: participates_in CCO:I0008731 ! alpha3-alpha2 physical interaction relationship: participates_in CCO:I0008733 ! alpha4-alpha2 physical interaction relationship: participates_in CCO:I0008735 ! alpha6-alpha2 physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041318 ! PSA2_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0041319 ! PSA2_HUMAN-Phosphotyrosine24 relationship: transforms_into CCO:B0041320 ! PSA2_HUMAN-Phosphotyrosine76 relationship: transforms_into CCO:B0041321 ! PSA2_HUMAN-Phosphotyrosine98 relationship: transforms_into CCO:B0041322 ! PSA2_HUMAN-Phosphotyrosine121 relationship: transforms_into CCO:B0041323 ! PSA2_HUMAN-Nitrated tyrosine229 [Term] id: CCO:B0041244 name: PSA4_HUMAN def: "Proteasome subunit alpha type-4" [UniProtKB:P25789] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P25789] synonym: "Macropain subunit C9" EXACT [UniProtKB:P25789] synonym: "Multicatalytic endopeptidase complex subunit C9" EXACT [UniProtKB:P25789] synonym: "Proteasome component C9" EXACT [UniProtKB:P25789] synonym: "Proteasome subunit L" EXACT [UniProtKB:P25789] xref: EMBL:AAH05361.1 xref: EMBL:AAH22445.1 xref: EMBL:AAH22817.2 xref: EMBL:AAH47667.1 xref: EMBL:BAA00660.1 xref: UniProtKB:P25789 xref: UniProtKB:Q8TBD1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013399 ! PSMA4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008706 ! traf6-psma4 physical interaction relationship: participates_in CCO:I0008729 ! alpha2-alpha4 physical interaction relationship: participates_in CCO:I0008730 ! alpha3-alpha4 physical interaction relationship: participates_in CCO:I0008732 ! alpha4-alpha3 physical interaction relationship: participates_in CCO:I0008733 ! alpha4-alpha2 physical interaction relationship: participates_in CCO:I0008734 ! alpha4-alpha7 physical interaction relationship: participates_in CCO:I0008738 ! alpha7-alpha4 physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041324 ! PSA4_HUMAN-Phosphoserine13 relationship: transforms_into CCO:B0041325 ! PSA4_HUMAN-Phosphoserine75 [Term] id: CCO:B0041245 name: PSB4_HUMAN def: "Proteasome subunit beta type-4 precursor" [UniProtKB:P28070] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P28070] synonym: "HsBPROS26" EXACT [UniProtKB:P28070] synonym: "HSN3" EXACT [UniProtKB:P28070] synonym: "Macropain beta chain" EXACT [UniProtKB:P28070] synonym: "Multicatalytic endopeptidase complex beta chain" EXACT [UniProtKB:P28070] synonym: "Proteasome beta chain" EXACT [UniProtKB:P28070] synonym: "Proteasome chain 3" EXACT [UniProtKB:P28070] xref: EMBL:AAB31085.1 xref: EMBL:AAH00331.1 xref: EMBL:AAH08314.1 xref: EMBL:AAH10088.1 xref: EMBL:AAH10098.1 xref: EMBL:AAH11768.1 xref: EMBL:AAH12168.1 xref: EMBL:AAH17307.1 xref: EMBL:AAH17451.1 xref: EMBL:AAH17486.1 xref: EMBL:AAP35563.1 xref: EMBL:BAA05647.1 xref: UniProtKB:P28070 xref: UniProtKB:P31148 xref: UniProtKB:Q969L6 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013401 ! PSMB4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041327 ! PSB4_HUMAN-Phosphotyrosine102 [Term] id: CCO:B0041246 name: PRS7_HUMAN def: "26S protease regulatory subunit 7" [UniProtKB:P35998] synonym: "Proteasome 26S subunit ATPase 2" EXACT [UniProtKB:P35998] synonym: "Protein MSS1" EXACT [UniProtKB:P35998] xref: EMBL:AAH02589.1 xref: EMBL:BAA01868.1 xref: UniProtKB:P35998 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013396 ! PSMC2_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001655 ! ATP binding relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0003445 ! ATPase activity relationship: has_function CCO:F0003574 ! nucleoside-triphosphatase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: participates_in CCO:I0008697 ! psmc2-psmd5 physical interaction relationship: participates_in CCO:I0008715 ! traf6-psmc2 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0041247 name: PRS6B_HUMAN def: "26S protease regulatory subunit 6B" [UniProtKB:P43686] synonym: "MB67-interacting protein" EXACT [UniProtKB:P43686] synonym: "MIP224" EXACT [UniProtKB:P43686] synonym: "Proteasome 26S subunit ATPase 4" EXACT [UniProtKB:P43686] synonym: "TAT-binding protein 7" EXACT [UniProtKB:P43686] synonym: "TBP-7" EXACT [UniProtKB:P43686] xref: EMBL:AAC26843.1 xref: EMBL:AAC32612.1 xref: EMBL:AAC99817.1 xref: EMBL:AAD39267.1 xref: EMBL:AAH00343.1 xref: EMBL:AAH10396.1 xref: EMBL:AAH14488.1 xref: EMBL:AAP35896.1 xref: UniProtKB:P43686 xref: UniProtKB:Q96FV5 xref: UniProtKB:Q9UBM3 xref: UniProtKB:Q9UEX3 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013395 ! PSMC4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008677 ! psmc4-psmc5 physical interaction relationship: participates_in CCO:I0008699 ! psmc4-psmd10 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041316 ! PRS6B_HUMAN-N-acetylmethionine1 [Term] id: CCO:B0041248 name: UB2E1_HUMAN def: "Ubiquitin-conjugating enzyme E2 E1" [UniProtKB:P51965] synonym: "EC 6.3.2.19" EXACT [UniProtKB:P51965] synonym: "UbcH6" EXACT [UniProtKB:P51965] synonym: "Ubiquitin carrier protein E1" EXACT [UniProtKB:P51965] synonym: "Ubiquitin-protein ligase E1" EXACT [UniProtKB:P51965] xref: EMBL:AAH09139.1 xref: EMBL:CAA63539.1 xref: UniProtKB:P51965 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013410 ! UBE2E1_human relationship: has_function CCO:F0001198 ! ubiquitin-protein ligase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0003433 ! ligase activity relationship: has_function CCO:F0004170 ! small conjugating protein ligase activity relationship: has_function CCO:F0008371 ! ISG15 ligase activity relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000262 ! nucleoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: participates_in CCO:I0008771 ! hsrma1-ube2e1 physical interaction relationship: participates_in CCO:I0008812 ! ube2e1-cbwd3 physical interaction relationship: participates_in CCO:I0008813 ! ube2e1-paep physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0041249 name: HMGA2_HUMAN def: "High mobility group protein HMGI-C" [UniProtKB:P52926] synonym: "High mobility group AT-hook protein 2" EXACT [UniProtKB:P52926] xref: EMBL:AAA68613.1 xref: EMBL:AAA68614.1 xref: EMBL:AAA96484.1 xref: EMBL:CAA63295.1 xref: EMBL:CAA83472.1 xref: UniProtKB:P52926 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0011851 ! HMGA2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008767 ! hrmt1l2-hmga2 physical interaction relationship: participates_in CCO:I0008768 ! hrmt1l6-hmg2a physical interaction relationship: participates_in CCO:I0008770 ! hrmt1l6-hmga2 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0041306 ! HMGA2_HUMAN-Phosphoserine105 [Term] id: CCO:B0041250 name: PSMD4_HUMAN def: "26S proteasome non-ATPase regulatory subunit 4" [UniProtKB:P55036] synonym: "26S proteasome regulatory subunit S5A" EXACT [UniProtKB:P55036] synonym: "AF" EXACT [UniProtKB:P55036] synonym: "Antisecretory factor 1" EXACT [UniProtKB:P55036] synonym: "ASF" EXACT [UniProtKB:P55036] synonym: "Multiubiquitin chain-binding protein" EXACT [UniProtKB:P55036] synonym: "Rpn10" EXACT [UniProtKB:P55036] xref: EMBL:AAB54057.1 xref: EMBL:AAB68598.1 xref: EMBL:AAC50433.1 xref: EMBL:AAH02365.1 xref: EMBL:AAH72008.1 xref: EMBL:BAA97581.1 xref: EMBL:CAH70329.1 xref: EMBL:CAI16390.1 xref: UniProtKB:P55036 xref: UniProtKB:Q5VWC5 xref: UniProtKB:Q9NS92 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013403 ! PSMD4_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008690 ! c12orf2-psmd4 physical interaction relationship: participates_in CCO:I0008708 ! traf6-psmd4 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041330 ! PSMD4_HUMAN-Phosphothreonine250 relationship: transforms_into CCO:B0041331 ! PSMD4_HUMAN-Phosphoserine256 relationship: transforms_into CCO:B0041332 ! PSMD4_HUMAN-Phosphoserine266 relationship: transforms_into CCO:B0041333 ! PSMD4_HUMAN-Phosphoserine358 relationship: transforms_into CCO:B0041334 ! PSMD4_HUMAN-Phosphoserine361 [Term] id: CCO:B0041251 name: PSA6_HUMAN def: "Proteasome subunit alpha type-6" [UniProtKB:P60900] synonym: "27 kDa prosomal protein" EXACT [UniProtKB:P60900] synonym: "EC 3.4.25.1" EXACT [UniProtKB:P60900] synonym: "Macropain iota chain" EXACT [UniProtKB:P60900] synonym: "Multicatalytic endopeptidase complex iota chain" EXACT [UniProtKB:P60900] synonym: "p27K" EXACT [UniProtKB:P60900] synonym: "PROS-27" EXACT [UniProtKB:P60900] synonym: "Proteasome iota chain" EXACT [UniProtKB:P60900] xref: EMBL:AAH02979.1 xref: EMBL:AAH17882.1 xref: EMBL:AAH22354.1 xref: EMBL:AAH23659.1 xref: EMBL:AAH70137.1 xref: EMBL:CAA42052.1 xref: EMBL:CAA43964.1 xref: EMBL:CAG33225.1 xref: UniProtKB:P34062 xref: UniProtKB:P60900 xref: UniProtKB:Q6IB60 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013400 ! PSMA6_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008735 ! alpha6-alpha2 physical interaction relationship: participates_in CCO:I0008736 ! alpha6-alpha7 physical interaction relationship: participates_in CCO:I0008739 ! alpha7-alpha6 physical interaction relationship: participates_in CCO:I0008773 ! 20s proteasome-1 physical interaction relationship: participates_in CCO:I0008792 ! psma3-psma6-1 physical interaction relationship: participates_in CCO:I0008793 ! 20s proteasome physical interaction relationship: participates_in CCO:I0008795 ! psma6-psma3 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041326 ! PSA6_HUMAN-Phosphotyrosine159 [Term] id: CCO:B0041252 name: PSME3_HUMAN def: "Proteasome activator complex subunit 3" [UniProtKB:P61289] synonym: "11S regulator complex subunit gamma" EXACT [UniProtKB:P61289] synonym: "Activator of multicatalytic protease subunit 3" EXACT [UniProtKB:P61289] synonym: "Ki nuclear autoantigen" EXACT [UniProtKB:P61289] synonym: "PA28g" EXACT [UniProtKB:P61289] synonym: "PA28gamma" EXACT [UniProtKB:P61289] synonym: "Proteasome activator 28 subunit gamma" EXACT [UniProtKB:P61289] synonym: "REG-gamma" EXACT [UniProtKB:P61289] xref: EMBL:AAA93227.1 xref: EMBL:AAB60335.1 xref: EMBL:AAH01423.1 xref: EMBL:AAH02684.1 xref: EMBL:AAH08020.1 xref: EMBL:AAV38193.1 xref: UniProtKB:O35563 xref: UniProtKB:P61289 xref: UniProtKB:P97373 xref: UniProtKB:Q12920 xref: UniProtKB:Q13172 xref: UniProtKB:Q9BQD9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013406 ! PSME3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008679 ! psme3-zcchc10 physical interaction relationship: participates_in CCO:I0008683 ! bbs2-psme3 physical interaction relationship: participates_in CCO:I0008684 ! psme3-serf2 physical interaction relationship: participates_in CCO:I0008688 ! psme3-psme3-1 physical interaction relationship: participates_in CCO:I0008693 ! itpkb-psme3 physical interaction relationship: participates_in CCO:I0008700 ! ncoa3-psme3-2 physical interaction relationship: participates_in CCO:I0008702 ! ncoa3-psme3 physical interaction relationship: participates_in CCO:I0008704 ! nfkbie-psme3 physical interaction relationship: participates_in CCO:I0008760 ! dtnbp1-psme3 physical interaction relationship: participates_in CCO:I0008762 ! psme3-coil physical interaction relationship: participates_in CCO:I0008764 ! atn1-psme3-2 physical interaction relationship: participates_in CCO:I0008765 ! coil-psme3-1 physical interaction relationship: participates_in CCO:I0008769 ! ncoa3-psme3-1 physical interaction relationship: participates_in CCO:I0008781 ! atn1-psme3 physical interaction relationship: participates_in CCO:I0008783 ! atn1-psme3-1 physical interaction relationship: participates_in CCO:I0008786 ! coil-psme3 physical interaction relationship: participates_in CCO:I0008790 ! ncoa3-psme3-3 direct interaction relationship: participates_in CCO:I0008791 ! ncoa3-psme3-4 direct interaction relationship: participates_in CCO:I0008801 ! psme3-hspa5 physical interaction relationship: participates_in CCO:I0008808 ! psme3-atp5b physical interaction relationship: participates_in CCO:I0008809 ! psme3-centa1 physical interaction relationship: participates_in CCO:I0008810 ! psme3-psme3 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041337 ! PSME3_HUMAN-Phosphothreonine205 relationship: transforms_into CCO:B0041338 ! PSME3_HUMAN-Phosphothreonine207 [Term] id: CCO:B0041253 name: PRS8_HUMAN def: "26S protease regulatory subunit 8" [UniProtKB:P62195] synonym: "p45/SUG" EXACT [UniProtKB:P62195] synonym: "Proteasome 26S subunit ATPase 5" EXACT [UniProtKB:P62195] synonym: "Proteasome subunit p45" EXACT [UniProtKB:P62195] synonym: "Thyroid hormone receptor-interacting protein 1" EXACT [UniProtKB:P62195] synonym: "TRIP1" EXACT [UniProtKB:P62195] xref: EMBL:AAB88187.1 xref: EMBL:AAC41735.1 xref: EMBL:AAH01932.1 xref: EMBL:AAH02367.3 xref: EMBL:BAA07919.1 xref: UniProtKB:O35051 xref: UniProtKB:O43208 xref: UniProtKB:P47210 xref: UniProtKB:P52915 xref: UniProtKB:P52916 xref: UniProtKB:P62195 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013397 ! PSMC5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008677 ! psmc4-psmc5 physical interaction relationship: participates_in CCO:I0008685 ! psmc5-rora physical interaction relationship: participates_in CCO:I0008687 ! psmc5-tnnt1 physical interaction relationship: participates_in CCO:I0008696 ! krt15-psmc5 physical interaction relationship: participates_in CCO:I0008709 ! traf6-psmc5 physical interaction relationship: participates_in CCO:I0008763 ! psmc5-rora-1 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041317 ! PRS8_HUMAN-N-acetylalanine2 [Term] id: CCO:B0041254 name: PTOR1_HUMAN def: "Protor-1" [UniProtKB:P85299] synonym: "Proline-rich protein 5" EXACT [UniProtKB:P85299] synonym: "Protein observed with Rictor-1" EXACT [UniProtKB:P85299] xref: EMBL:AAG17975.1 xref: EMBL:AAH16921.1 xref: EMBL:BAA90999.1 xref: EMBL:DAA05654.1 xref: EMBL:DAA05655.1 xref: EMBL:DAA05656.1 xref: EMBL:DAA05657.1 xref: EMBL:DAA05658.1 xref: UniProtKB:O75983 xref: UniProtKB:O95695 xref: UniProtKB:P85299 xref: UniProtKB:Q5BIW2 xref: UniProtKB:Q5EAJ8 xref: UniProtKB:Q5EAJ9 xref: UniProtKB:Q5XKJ6 xref: UniProtKB:Q96RW1 xref: UniProtKB:Q96RW2 xref: UniProtKB:Q9HA49 xref: UniProtKB:Q9HC46 xref: UniProtKB:Q9NSG0 xref: UniProtKB:Q9NVX8 xref: UniProtKB:Q9NXL1 xref: UniProtKB:Q9UH20 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013408 ! PROTOR1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0041255 name: PSMD5_HUMAN def: "26S proteasome non-ATPase regulatory subunit 5" [UniProtKB:Q16401] synonym: "26S protease subunit S5 basic" EXACT [UniProtKB:Q16401] synonym: "26S proteasome subunit S5B" EXACT [UniProtKB:Q16401] xref: EMBL:AAB35397.1 xref: EMBL:AAH14478.1 xref: EMBL:BAA06687.1 xref: UniProtKB:Q15045 xref: UniProtKB:Q16401 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013404 ! PSMD5_human relationship: has_function CCO:F0001633 ! binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: participates_in CCO:I0008697 ! psmc2-psmd5 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: transforms_into CCO:B0041335 ! PSMD5_HUMAN-N-acetylalanine2 [Term] id: CCO:B0041256 name: ERC6L_HUMAN def: "DNA excision repair protein ERCC-6-like" [UniProtKB:Q2NKX8] synonym: "ATP-dependent helicase ERCC6-like" EXACT [UniProtKB:Q2NKX8] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q2NKX8] synonym: "PLK1-interacting checkpoint helicase" EXACT [UniProtKB:Q2NKX8] synonym: "Tumor antigen BJ-HCC-15" EXACT [UniProtKB:Q2NKX8] xref: EMBL:AAH08808.1 xref: EMBL:AAI11487.1 xref: EMBL:AAM82750.1 xref: EMBL:ABU25227.1 xref: EMBL:BAA90952.1 xref: EMBL:BAC11160.1 xref: UniProtKB:Q2NKX8 xref: UniProtKB:Q8NCI1 xref: UniProtKB:Q96H93 xref: UniProtKB:Q9NXQ8 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013389 ! ERCC6L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis relationship: transforms_into CCO:B0041302 ! ERC6L_HUMAN-Phosphoserine1021 relationship: transforms_into CCO:B0041303 ! ERC6L_HUMAN-Phosphothreonine1063 [Term] id: CCO:B0041257 name: E4F1_HUMAN def: "Transcription factor E4F1" [UniProtKB:Q66K89] synonym: "E4F transcription factor 1" EXACT [UniProtKB:Q66K89] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q66K89] synonym: "p120E4F" EXACT [UniProtKB:Q66K89] synonym: "p50E4F" EXACT [UniProtKB:Q66K89] synonym: "Putative E3 ubiquitin-protein ligase E4F1" EXACT [UniProtKB:Q66K89] synonym: "Transcription factor E4F" EXACT [UniProtKB:Q66K89] xref: EMBL:AAD09139.1 xref: EMBL:AAH80524.1 xref: EMBL:BAF83018.1 xref: EMBL:EAW85532.1 xref: UniProtKB:A8K2R4 xref: UniProtKB:O00146 xref: UniProtKB:Q66K89 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013388 ! E4F1_human relationship: has_function CCO:F0000273 ! nucleic acid binding relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000289 ! transcription factor activity relationship: has_function CCO:F0000300 ! transcription coactivator activity relationship: has_function CCO:F0000301 ! transcription corepressor activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001810 ! zinc ion binding relationship: has_function CCO:F0003433 ! ligase activity relationship: has_function CCO:F0006257 ! metal ion binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000242 ! intracellular relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000081 ! mitosis [Term] id: CCO:B0041258 name: XAF1_HUMAN def: "XIAP-associated factor 1" [UniProtKB:Q6GPH4] synonym: "BIRC4-binding protein" EXACT [UniProtKB:Q6GPH4] xref: EMBL:AAH32776.1 xref: EMBL:AAH73156.1 xref: EMBL:ABM74556.1 xref: EMBL:ABM74557.1 xref: EMBL:BAF82965.1 xref: EMBL:BAF85399.1 xref: EMBL:BAF85537.1 xref: EMBL:CAA68030.1 xref: EMBL:CAE46206.1 xref: EMBL:EAW90288.1 xref: UniProtKB:A2T931 xref: UniProtKB:A2T932 xref: UniProtKB:A8K2L1 xref: UniProtKB:A8K9Y3 xref: UniProtKB:Q6GPH4 xref: UniProtKB:Q6MZE8 xref: UniProtKB:Q8N557 xref: UniProtKB:Q99982 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013412 ! XAF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0041259 name: CNDH2_HUMAN def: "Condensin-2 complex subunit H2" [UniProtKB:Q6IBW4] synonym: "Chromosome-associated protein H2" EXACT [UniProtKB:Q6IBW4] synonym: "hCAP-H2" EXACT [UniProtKB:Q6IBW4] synonym: "Kleisin-beta" EXACT [UniProtKB:Q6IBW4] synonym: "Non-SMC condensin II complex subunit H2" EXACT [UniProtKB:Q6IBW4] xref: EMBL:AAB03345.1 xref: EMBL:AAH00473.1 xref: EMBL:AAH01298.1 xref: EMBL:AAH01509.1 xref: EMBL:AAH01833.1 xref: EMBL:AAH01937.1 xref: EMBL:AAH09441.1 xref: EMBL:AAH14939.2 xref: EMBL:CAA16670.1 xref: EMBL:CAG30490.1 xref: EMBL:EAW73552.1 xref: EMBL:EAW73556.1 xref: UniProtKB:O43788 xref: UniProtKB:Q13391 xref: UniProtKB:Q6IBW4 xref: UniProtKB:Q96C14 xref: UniProtKB:Q96GJ0 xref: UniProtKB:Q9BQ71 xref: UniProtKB:Q9BUT3 xref: UniProtKB:Q9BVD1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013385 ! NCAPH2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation relationship: transforms_into CCO:B0041287 ! CNDH2_HUMAN-Phosphoserine95 relationship: transforms_into CCO:B0041288 ! CNDH2_HUMAN-Phosphoserine120 relationship: transforms_into CCO:B0041289 ! CNDH2_HUMAN-Phosphoserine200 relationship: transforms_into CCO:B0041290 ! CNDH2_HUMAN-Phosphoserine228 relationship: transforms_into CCO:B0041291 ! CNDH2_HUMAN-Phosphoserine284 relationship: transforms_into CCO:B0041292 ! CNDH2_HUMAN-Phosphoserine319 relationship: transforms_into CCO:B0041293 ! CNDH2_HUMAN-Phosphoserine466 relationship: transforms_into CCO:B0041294 ! CNDH2_HUMAN-Phosphoserine492 [Term] id: CCO:B0041260 name: CP110_HUMAN def: "Centriolin" [UniProtKB:Q7Z7A1] synonym: "110 kDa centrosomal protein" EXACT [UniProtKB:Q7Z7A1] synonym: "Centrosomal protein 1" EXACT [UniProtKB:Q7Z7A1] xref: EMBL:AAC32373.1 xref: EMBL:AAH02932.1 xref: EMBL:AAH89415.1 xref: EMBL:AAP43846.1 xref: EMBL:AAX35689.1 xref: EMBL:BAB84905.1 xref: EMBL:CAE45965.1 xref: EMBL:CAI12358.1 xref: EMBL:CAM13285.1 xref: UniProtKB:A2A2Y1 xref: UniProtKB:Q3MN79 xref: UniProtKB:Q5FWF8 xref: UniProtKB:Q5JVD0 xref: UniProtKB:Q6MZR3 xref: UniProtKB:Q6PKC1 xref: UniProtKB:Q7Z7A1 xref: UniProtKB:Q8TEP3 xref: UniProtKB:Q9Y489 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0004316 ! CEP110_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: transforms_into CCO:B0041295 ! CP110_HUMAN-Phosphotyrosine117 relationship: transforms_into CCO:B0041296 ! CP110_HUMAN-Phosphothreonine286 relationship: transforms_into CCO:B0041297 ! CP110_HUMAN-Phosphothreonine1668 relationship: transforms_into CCO:B0041298 ! CP110_HUMAN-Phosphothreonine1671 [Term] id: CCO:B0041261 name: ERF3B_HUMAN def: "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B" [UniProtKB:Q8IYD1] synonym: "eRF3b" EXACT [UniProtKB:Q8IYD1] synonym: "Eukaryotic peptide chain release factor subunit 3b" EXACT [UniProtKB:Q8IYD1] synonym: "G1 to S phase transition protein 2 homolog" EXACT [UniProtKB:Q8IYD1] xref: EMBL:AAH36077.1 xref: EMBL:BAA91612.1 xref: EMBL:BAB14435.1 xref: EMBL:CAB91089.1 xref: EMBL:CAH71524.1 xref: EMBL:EAW62898.1 xref: UniProtKB:Q8IYD1 xref: UniProtKB:Q9H909 xref: UniProtKB:Q9NVY0 xref: UniProtKB:Q9NY44 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0008865 ! GSPT2_human relationship: has_function CCO:F0000031 ! nucleotide binding relationship: has_function CCO:F0000318 ! translation release factor activity relationship: has_function CCO:F0000427 ! GTPase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001656 ! GTP binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000324 ! cytoplasm relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0041262 name: CTF8_HUMAN def: "Chromosome transmission fidelity protein 8" [UniProtKB:Q8WV66] synonym: "hCTF8" EXACT [UniProtKB:Q8WV66] xref: EMBL:AAH18700.4 xref: UniProtKB:A8MYX8 xref: UniProtKB:Q8WV66 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013386 ! CTF8_human relationship: has_function CCO:F0000274 ! DNA binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0041263 name: PSMF1_HUMAN def: "Proteasome inhibitor PI31 subunit" [UniProtKB:Q92530] synonym: "hPI31" EXACT [UniProtKB:Q92530] xref: EMBL:AAI26463.1 xref: EMBL:BAA13603.1 xref: EMBL:CAC10383.1 xref: UniProtKB:A0AVQ9 xref: UniProtKB:Q92530 xref: UniProtKB:Q9H4I1 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013407 ! PSMF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008701 ! a2bp1-psmf1 physical interaction relationship: participates_in CCO:I0008766 ! psmf1-a2bp1 physical interaction relationship: participates_in CCO:P0000333 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: participates_in CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle [Term] id: CCO:B0041264 name: PRDBP_HUMAN def: "Protein kinase C delta-binding protein" [UniProtKB:Q969G5] synonym: "hSRBC" EXACT [UniProtKB:Q969G5] synonym: "Serum deprivation response factor-related gene product that binds to C-kinase" EXACT [UniProtKB:Q969G5] xref: EMBL:AAH11585.1 xref: EMBL:AAK97528.1 xref: EMBL:AAK97572.1 xref: EMBL:EAW68733.1 xref: UniProtKB:Q969G5 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013393 ! PRKCDBP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle relationship: transforms_into CCO:B0041311 ! PRDBP_HUMAN-Phosphoserine4 relationship: transforms_into CCO:B0041312 ! PRDBP_HUMAN-Phosphoserine165 relationship: transforms_into CCO:B0041313 ! PRDBP_HUMAN-Phosphoserine166 [Term] id: CCO:B0041265 name: MTBP_HUMAN def: "Mdm2-binding protein" [UniProtKB:Q96DY7] synonym: "hMTBP" EXACT [UniProtKB:Q96DY7] xref: EMBL:AAH13136.1 xref: EMBL:BAB13965.1 xref: EMBL:EAW92006.1 xref: EMBL:EAW92007.1 xref: UniProtKB:Q96DY7 xref: UniProtKB:Q9HA89 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013392 ! MTBP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000067 ! cell cycle arrest [Term] id: CCO:B0041266 name: CINP_HUMAN def: "Cyclin-dependent kinase 2-interacting protein" [UniProtKB:Q9BW66] xref: EMBL:AAF44747.1 xref: EMBL:AAF44748.1 xref: EMBL:AAH00600.1 xref: EMBL:BAB71095.1 xref: EMBL:CAG33459.1 xref: EMBL:EAW81785.1 xref: UniProtKB:Q9BW66 xref: UniProtKB:Q9NPF9 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013384 ! CINP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: participates_in CCO:I0008675 ! cinp-cluap1 physical interaction relationship: participates_in CCO:P0000066 ! cell cycle [Term] id: CCO:B0041267 name: DMTF1_HUMAN def: "Cyclin-D-binding Myb-like transcription factor 1" [UniProtKB:Q9Y222] synonym: "Cyclin-D-interacting Myb-like protein 1" EXACT [UniProtKB:Q9Y222] synonym: "hDMP1" EXACT [UniProtKB:Q9Y222] synonym: "hDMTF1" EXACT [UniProtKB:Q9Y222] xref: EMBL:AAC33480.1 xref: EMBL:AAD43181.1 xref: EMBL:AAG35613.1 xref: EMBL:AAG35614.1 xref: EMBL:AAH07418.2 xref: EMBL:AAH07447.2 xref: EMBL:AAH29370.1 xref: EMBL:AAH70064.1 xref: EMBL:BAD92467.1 xref: EMBL:EAW76963.1 xref: UniProtKB:Q05C48 xref: UniProtKB:Q59G79 xref: UniProtKB:Q6IS13 xref: UniProtKB:Q969T2 xref: UniProtKB:Q9H2Z2 xref: UniProtKB:Q9H2Z3 xref: UniProtKB:Q9Y222 is_a: CCO:B0000000 ! core cell cycle protein relationship: encoded_by CCO:G0013387 ! DMTF1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:P0000066 ! cell cycle relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle [Term] id: CCO:B0041276 name: MISSL_HUMAN def: "MAPK-interacting and spindle-stabilizing protein-like" [UniProtKB:Q8NDC0] synonym: "Mitogen-activated protein kinase 1-interacting protein 1-like" EXACT [UniProtKB:Q8NDC0] xref: EMBL:AAH15621.1 xref: EMBL:CAD38959.2 xref: UniProtKB:Q8NDC0 xref: UniProtKB:Q96BG5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0013391 ! MAPK1IP1L_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0005736 ! c14orf32-ube2i physical interaction relationship: transforms_into CCO:B0041309 ! MISSL_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0041310 ! MISSL_HUMAN-Phosphoserine15 [Term] id: CCO:B0041277 name: GUSP1_HUMAN def: "Beta-glucuronidase-like protein SMA3" [UniProtKB:Q15486] xref: EMBL:AAH50737.1 xref: EMBL:AAP35406.1 xref: EMBL:CAA58278.1 xref: EMBL:CAC69829.1 xref: EMBL:CAC69830.1 xref: UniProtKB:Q15486 xref: UniProtKB:Q969T8 xref: UniProtKB:Q9BUH2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0013390 ! GUSBP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008052 ! sma3-tp53 physical interaction [Term] id: CCO:B0041278 name: HBXIP_HUMAN def: "Hepatitis B virus X-interacting protein" [UniProtKB:O43504] synonym: "HBV X-interacting protein" EXACT [UniProtKB:O43504] synonym: "HBX-interacting protein" EXACT [UniProtKB:O43504] xref: EMBL:AAC52032.1 xref: EMBL:AAH62619.2 xref: EMBL:AAV30683.1 xref: EMBL:CAG33147.1 xref: EMBL:CAG46927.1 xref: EMBL:CAH71488.1 xref: UniProtKB:O43504 xref: UniProtKB:Q6IBD8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0005937 ! HBXIP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008116 ! hbxip-rif1 physical interaction relationship: transforms_into CCO:B0041304 ! HBXIP_HUMAN-N-acetylmethionine1 relationship: transforms_into CCO:B0041305 ! HBXIP_HUMAN-Phosphoserine26 [Term] id: CCO:B0041279 name: TM90B_HUMAN def: "Transmembrane protein 90B" [UniProtKB:Q9H7V2] xref: EMBL:AAH30637.1 xref: EMBL:BAB14872.1 xref: EMBL:CAG33606.1 xref: EMBL:CAI15132.1 xref: EMBL:CAI23040.1 xref: UniProtKB:Q6IA30 xref: UniProtKB:Q9H514 xref: UniProtKB:Q9H7V2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0013409 ! TMEM90B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008487 ! pfdn1-c20orf39 physical interaction [Term] id: CCO:B0041283 name: ABI1_HUMAN-N-acetylalanine2 def: "Protein ABI1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q8IZP0] xref: UniProtKB:Q8IZP0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005703 ! ABI1_HUMAN [Term] id: CCO:B0041284 name: ANXA3_HUMAN-N-acetylalanine2 def: "Protein ANXA3_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P12429] xref: UniProtKB:P12429 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006119 ! ANXA3_HUMAN [Term] id: CCO:B0041285 name: CAZA2_HUMAN-N-acetylalanine2 def: "Protein CAZA2_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P47755] xref: UniProtKB:P47755 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005582 ! CAZA2_HUMAN [Term] id: CCO:B0041286 name: CG020_HUMAN-N-acetylalanine2 def: "Protein CG020_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q7L5D6] xref: UniProtKB:Q7L5D6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006174 ! CG020_HUMAN [Term] id: CCO:B0041287 name: CNDH2_HUMAN-Phosphoserine95 def: "Protein CNDH2_HUMAN with the residue 95 substituted with Phosphoserine" [UniProtKB:Q6IBW4] xref: UniProtKB:Q6IBW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041259 ! CNDH2_HUMAN [Term] id: CCO:B0041288 name: CNDH2_HUMAN-Phosphoserine120 def: "Protein CNDH2_HUMAN with the residue 120 substituted with Phosphoserine" [UniProtKB:Q6IBW4] xref: UniProtKB:Q6IBW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041259 ! CNDH2_HUMAN [Term] id: CCO:B0041289 name: CNDH2_HUMAN-Phosphoserine200 def: "Protein CNDH2_HUMAN with the residue 200 substituted with Phosphoserine" [UniProtKB:Q6IBW4] xref: UniProtKB:Q6IBW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041259 ! CNDH2_HUMAN [Term] id: CCO:B0041290 name: CNDH2_HUMAN-Phosphoserine228 def: "Protein CNDH2_HUMAN with the residue 228 substituted with Phosphoserine" [UniProtKB:Q6IBW4] xref: UniProtKB:Q6IBW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041259 ! CNDH2_HUMAN [Term] id: CCO:B0041291 name: CNDH2_HUMAN-Phosphoserine284 def: "Protein CNDH2_HUMAN with the residue 284 substituted with Phosphoserine" [UniProtKB:Q6IBW4] xref: UniProtKB:Q6IBW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041259 ! CNDH2_HUMAN [Term] id: CCO:B0041292 name: CNDH2_HUMAN-Phosphoserine319 def: "Protein CNDH2_HUMAN with the residue 319 substituted with Phosphoserine" [UniProtKB:Q6IBW4] xref: UniProtKB:Q6IBW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041259 ! CNDH2_HUMAN [Term] id: CCO:B0041293 name: CNDH2_HUMAN-Phosphoserine466 def: "Protein CNDH2_HUMAN with the residue 466 substituted with Phosphoserine" [UniProtKB:Q6IBW4] xref: UniProtKB:Q6IBW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041259 ! CNDH2_HUMAN [Term] id: CCO:B0041294 name: CNDH2_HUMAN-Phosphoserine492 def: "Protein CNDH2_HUMAN with the residue 492 substituted with Phosphoserine" [UniProtKB:Q6IBW4] xref: UniProtKB:Q6IBW4 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041259 ! CNDH2_HUMAN [Term] id: CCO:B0041295 name: CP110_HUMAN-Phosphotyrosine117 def: "Protein CP110_HUMAN with the residue 117 substituted with Phosphotyrosine" [UniProtKB:Q7Z7A1] xref: UniProtKB:Q7Z7A1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041260 ! CP110_HUMAN [Term] id: CCO:B0041296 name: CP110_HUMAN-Phosphothreonine286 def: "Protein CP110_HUMAN with the residue 286 substituted with Phosphothreonine" [UniProtKB:Q7Z7A1] xref: UniProtKB:Q7Z7A1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041260 ! CP110_HUMAN [Term] id: CCO:B0041297 name: CP110_HUMAN-Phosphothreonine1668 def: "Protein CP110_HUMAN with the residue 1668 substituted with Phosphothreonine" [UniProtKB:Q7Z7A1] xref: UniProtKB:Q7Z7A1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041260 ! CP110_HUMAN [Term] id: CCO:B0041298 name: CP110_HUMAN-Phosphothreonine1671 def: "Protein CP110_HUMAN with the residue 1671 substituted with Phosphothreonine" [UniProtKB:Q7Z7A1] xref: UniProtKB:Q7Z7A1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041260 ! CP110_HUMAN [Term] id: CCO:B0041299 name: EI2BG_HUMAN-N-acetylmethionine1 def: "Protein EI2BG_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:Q9NR50] xref: UniProtKB:Q9NR50 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005834 ! EI2BG_HUMAN [Term] id: CCO:B0041300 name: EIF3E_HUMAN-N-acetylalanine2 def: "Protein EIF3E_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P60228] xref: UniProtKB:P60228 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026272 ! EIF3E_HUMAN [Term] id: CCO:B0041301 name: EIF3J_HUMAN-N-acetylalanine2 def: "Protein EIF3J_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:O75822] xref: UniProtKB:O75822 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0026278 ! EIF3J_HUMAN [Term] id: CCO:B0041302 name: ERC6L_HUMAN-Phosphoserine1021 def: "Protein ERC6L_HUMAN with the residue 1021 substituted with Phosphoserine" [UniProtKB:Q2NKX8] comment: By similarity xref: UniProtKB:Q2NKX8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041256 ! ERC6L_HUMAN [Term] id: CCO:B0041303 name: ERC6L_HUMAN-Phosphothreonine1063 def: "Protein ERC6L_HUMAN with the residue 1063 substituted with Phosphothreonine" [UniProtKB:Q2NKX8] comment: by PLK1; xref: UniProtKB:Q2NKX8 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041256 ! ERC6L_HUMAN [Term] id: CCO:B0041304 name: HBXIP_HUMAN-N-acetylmethionine1 def: "Protein HBXIP_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:O43504] xref: UniProtKB:O43504 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041278 ! HBXIP_HUMAN [Term] id: CCO:B0041305 name: HBXIP_HUMAN-Phosphoserine26 def: "Protein HBXIP_HUMAN with the residue 26 substituted with Phosphoserine" [UniProtKB:O43504] xref: UniProtKB:O43504 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041278 ! HBXIP_HUMAN [Term] id: CCO:B0041306 name: HMGA2_HUMAN-Phosphoserine105 def: "Protein HMGA2_HUMAN with the residue 105 substituted with Phosphoserine" [UniProtKB:P52926] comment: By similarity xref: UniProtKB:P52926 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000274 ! DNA binding relationship: has_function CCO:F0000276 ! AT DNA binding relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000112 ! chromatin relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000296 ! chromosome relationship: transformation_of CCO:B0041249 ! HMGA2_HUMAN [Term] id: CCO:B0041307 name: HNRPK_HUMAN-N-acetylmethionine1 def: "Protein HNRPK_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P61978] xref: UniProtKB:P61978 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:B0041308 name: K2C6A_HUMAN-N-acetylalanine2 def: "Protein K2C6A_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P02538] xref: UniProtKB:P02538 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005821 ! K2C6A_HUMAN [Term] id: CCO:B0041309 name: MISSL_HUMAN-N-acetylserine2 def: "Protein MISSL_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:Q8NDC0] xref: UniProtKB:Q8NDC0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041276 ! MISSL_HUMAN [Term] id: CCO:B0041310 name: MISSL_HUMAN-Phosphoserine15 def: "Protein MISSL_HUMAN with the residue 15 substituted with Phosphoserine" [UniProtKB:Q8NDC0] xref: UniProtKB:Q8NDC0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041276 ! MISSL_HUMAN [Term] id: CCO:B0041311 name: PRDBP_HUMAN-Phosphoserine4 def: "Protein PRDBP_HUMAN with the residue 4 substituted with Phosphoserine" [UniProtKB:Q969G5] xref: UniProtKB:Q969G5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041264 ! PRDBP_HUMAN [Term] id: CCO:B0041312 name: PRDBP_HUMAN-Phosphoserine165 def: "Protein PRDBP_HUMAN with the residue 165 substituted with Phosphoserine" [UniProtKB:Q969G5] xref: UniProtKB:Q969G5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041264 ! PRDBP_HUMAN [Term] id: CCO:B0041313 name: PRDBP_HUMAN-Phosphoserine166 def: "Protein PRDBP_HUMAN with the residue 166 substituted with Phosphoserine" [UniProtKB:Q969G5] xref: UniProtKB:Q969G5 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041264 ! PRDBP_HUMAN [Term] id: CCO:B0041314 name: PRS6A_HUMAN-N-acetylmethionine1 def: "Protein PRS6A_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P17980] xref: UniProtKB:P17980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041242 ! PRS6A_HUMAN [Term] id: CCO:B0041315 name: PRS6A_HUMAN-Phosphoserine9 def: "Protein PRS6A_HUMAN with the residue 9 substituted with Phosphoserine" [UniProtKB:P17980] xref: UniProtKB:P17980 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041242 ! PRS6A_HUMAN [Term] id: CCO:B0041316 name: PRS6B_HUMAN-N-acetylmethionine1 def: "Protein PRS6B_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:P43686] xref: UniProtKB:P43686 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041247 ! PRS6B_HUMAN [Term] id: CCO:B0041317 name: PRS8_HUMAN-N-acetylalanine2 def: "Protein PRS8_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P62195] xref: UniProtKB:P62195 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041253 ! PRS8_HUMAN [Term] id: CCO:B0041318 name: PSA2_HUMAN-N-acetylalanine2 def: "Protein PSA2_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P25787] comment: By similarity xref: UniProtKB:P25787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041243 ! PSA2_HUMAN [Term] id: CCO:B0041319 name: PSA2_HUMAN-Phosphotyrosine24 def: "Protein PSA2_HUMAN with the residue 24 substituted with Phosphotyrosine" [UniProtKB:P25787] xref: UniProtKB:P25787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041243 ! PSA2_HUMAN [Term] id: CCO:B0041320 name: PSA2_HUMAN-Phosphotyrosine76 def: "Protein PSA2_HUMAN with the residue 76 substituted with Phosphotyrosine" [UniProtKB:P25787] comment: By similarity xref: UniProtKB:P25787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041243 ! PSA2_HUMAN [Term] id: CCO:B0041321 name: PSA2_HUMAN-Phosphotyrosine98 def: "Protein PSA2_HUMAN with the residue 98 substituted with Phosphotyrosine" [UniProtKB:P25787] xref: UniProtKB:P25787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041243 ! PSA2_HUMAN [Term] id: CCO:B0041322 name: PSA2_HUMAN-Phosphotyrosine121 def: "Protein PSA2_HUMAN with the residue 121 substituted with Phosphotyrosine" [UniProtKB:P25787] comment: By similarity xref: UniProtKB:P25787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041243 ! PSA2_HUMAN [Term] id: CCO:B0041323 name: PSA2_HUMAN-Nitrated tyrosine229 def: "Protein PSA2_HUMAN with the residue 229 substituted with Nitrated tyrosine" [UniProtKB:P25787] xref: UniProtKB:P25787 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041243 ! PSA2_HUMAN [Term] id: CCO:B0041324 name: PSA4_HUMAN-Phosphoserine13 def: "Protein PSA4_HUMAN with the residue 13 substituted with Phosphoserine" [UniProtKB:P25789] xref: UniProtKB:P25789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0000644 ! endopeptidase activity relationship: has_function CCO:F0000721 ! threonine endopeptidase activity relationship: has_function CCO:F0001646 ! protein binding relationship: has_function CCO:F0001783 ! peptidase activity relationship: has_function CCO:F0003359 ! hydrolase activity relationship: has_function CCO:F0005713 ! identical protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000252 ! nucleus relationship: located_in CCO:C0000324 ! cytoplasm relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: located_in CCO:C0002080 ! proteasome core complex relationship: transformation_of CCO:B0041244 ! PSA4_HUMAN [Term] id: CCO:B0041325 name: PSA4_HUMAN-Phosphoserine75 def: "Protein PSA4_HUMAN with the residue 75 substituted with Phosphoserine" [UniProtKB:P25789] xref: UniProtKB:P25789 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041244 ! PSA4_HUMAN [Term] id: CCO:B0041326 name: PSA6_HUMAN-Phosphotyrosine159 def: "Protein PSA6_HUMAN with the residue 159 substituted with Phosphotyrosine" [UniProtKB:P60900] comment: By similarity xref: UniProtKB:P60900 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041251 ! PSA6_HUMAN [Term] id: CCO:B0041327 name: PSB4_HUMAN-Phosphotyrosine102 def: "Protein PSB4_HUMAN with the residue 102 substituted with Phosphotyrosine" [UniProtKB:P28070] xref: UniProtKB:P28070 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041245 ! PSB4_HUMAN [Term] id: CCO:B0041328 name: PSD10_HUMAN-N-acetylmethionine1 def: "Protein PSD10_HUMAN with the residue 1 substituted with N-acetylmethionine" [UniProtKB:O75832] xref: UniProtKB:O75832 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: located_in CCO:C0002079 ! proteasome regulatory particle relationship: transformation_of CCO:B0041240 ! PSD10_HUMAN [Term] id: CCO:B0041329 name: PSDE_HUMAN-Phosphoserine150 def: "Protein PSDE_HUMAN with the residue 150 substituted with Phosphoserine" [UniProtKB:O00487] xref: UniProtKB:O00487 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0023606 ! PSDE_HUMAN [Term] id: CCO:B0041330 name: PSMD4_HUMAN-Phosphothreonine250 def: "Protein PSMD4_HUMAN with the residue 250 substituted with Phosphothreonine" [UniProtKB:P55036] comment: By similarity xref: UniProtKB:P55036 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041250 ! PSMD4_HUMAN [Term] id: CCO:B0041331 name: PSMD4_HUMAN-Phosphoserine256 def: "Protein PSMD4_HUMAN with the residue 256 substituted with Phosphoserine" [UniProtKB:P55036] comment: By similarity xref: UniProtKB:P55036 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041250 ! PSMD4_HUMAN [Term] id: CCO:B0041332 name: PSMD4_HUMAN-Phosphoserine266 def: "Protein PSMD4_HUMAN with the residue 266 substituted with Phosphoserine" [UniProtKB:P55036] xref: UniProtKB:P55036 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041250 ! PSMD4_HUMAN [Term] id: CCO:B0041333 name: PSMD4_HUMAN-Phosphoserine358 def: "Protein PSMD4_HUMAN with the residue 358 substituted with Phosphoserine" [UniProtKB:P55036] xref: UniProtKB:P55036 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002078 ! proteasome complex relationship: transformation_of CCO:B0041250 ! PSMD4_HUMAN [Term] id: CCO:B0041334 name: PSMD4_HUMAN-Phosphoserine361 def: "Protein PSMD4_HUMAN with the residue 361 substituted with Phosphoserine" [UniProtKB:P55036] xref: UniProtKB:P55036 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041250 ! PSMD4_HUMAN [Term] id: CCO:B0041335 name: PSMD5_HUMAN-N-acetylalanine2 def: "Protein PSMD5_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q16401] xref: UniProtKB:Q16401 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041255 ! PSMD5_HUMAN [Term] id: CCO:B0041336 name: PSMD9_HUMAN-Phosphoserine129 def: "Protein PSMD9_HUMAN with the residue 129 substituted with Phosphoserine" [UniProtKB:O00233] comment: By similarity xref: UniProtKB:O00233 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_function CCO:F0001646 ! protein binding relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: located_in CCO:C0000397 ! cytosol relationship: located_in CCO:C0001750 ! protein complex relationship: located_in CCO:C0002079 ! proteasome regulatory particle relationship: transformation_of CCO:B0041239 ! PSMD9_HUMAN [Term] id: CCO:B0041337 name: PSME3_HUMAN-Phosphothreonine205 def: "Protein PSME3_HUMAN with the residue 205 substituted with Phosphothreonine" [UniProtKB:P61289] comment: By similarity xref: UniProtKB:P61289 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:B0041338 name: PSME3_HUMAN-Phosphothreonine207 def: "Protein PSME3_HUMAN with the residue 207 substituted with Phosphothreonine" [UniProtKB:P61289] comment: By similarity xref: UniProtKB:P61289 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:B0041339 name: RBX1_HUMAN-N-acetylalanine2 def: "Protein RBX1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P62877] xref: UniProtKB:P62877 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005491 ! RBX1_HUMAN [Term] id: CCO:B0041340 name: RUVB2_HUMAN-N-acetylalanine2 def: "Protein RUVB2_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9Y230] xref: UniProtKB:Q9Y230 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005364 ! RUVB2_HUMAN [Term] id: CCO:B0041341 name: SSRP1_HUMAN-N-acetylalanine2 def: "Protein SSRP1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q08945] xref: UniProtKB:Q08945 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005769 ! SSRP1_HUMAN [Term] id: CCO:B0041342 name: SUGT1_HUMAN-N-acetylalanine2 def: "Protein SUGT1_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9Y2Z0] xref: UniProtKB:Q9Y2Z0 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0002252 ! SUGT1_HUMAN [Term] id: CCO:B0041343 name: SYK_HUMAN-N-acetylalanine2 def: "Protein SYK_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q15046] xref: UniProtKB:Q15046 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0006279 ! SYK_HUMAN [Term] id: CCO:B0041344 name: TCPE_HUMAN-N-acetylalanine2 def: "Protein TCPE_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:P48643] xref: UniProtKB:P48643 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0005291 ! TCPE_HUMAN [Term] id: CCO:B0041345 name: ZW10_HUMAN-N-acetylalanine2 def: "Protein ZW10_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:O43264] xref: UniProtKB:O43264 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0001387 ! ZW10_HUMAN [Term] id: CCO:B0043416 name: CLUA1_HUMAN def: "Clusterin-associated protein 1" [UniProtKB:Q96AJ1] xref: EMBL:AAH17070.3 xref: EMBL:BAA31618.1 xref: EMBL:BAB14523.1 xref: EMBL:BAB14542.1 xref: EMBL:BAD44779.1 xref: UniProtKB:O75138 xref: UniProtKB:Q65ZA3 xref: UniProtKB:Q96AJ1 xref: UniProtKB:Q9H8R4 xref: UniProtKB:Q9H8T1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014153 ! CLUAP1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008675 ! cinp-cluap1 physical interaction [Term] id: CCO:B0043417 name: TRI39_HUMAN def: "Tripartite motif-containing protein 39" [UniProtKB:Q9HCM9] synonym: "RING finger protein 23" EXACT [UniProtKB:Q9HCM9] synonym: "Testis-abundant finger protein" EXACT [UniProtKB:Q9HCM9] xref: EMBL:AAH07661.1 xref: EMBL:AAH34985.1 xref: EMBL:AAP36034.1 xref: EMBL:BAB16374.1 xref: EMBL:BAD13703.1 xref: UniProtKB:Q76BL3 xref: UniProtKB:Q8IYT9 xref: UniProtKB:Q96IB6 xref: UniProtKB:Q9HCM9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014179 ! TRIM39_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008676 ! trim39-ube2d1 physical interaction relationship: transforms_into CCO:B0043495 ! TRI39_HUMAN-Phosphotyrosine439 [Term] id: CCO:B0043418 name: RN126_HUMAN def: "RING finger protein 126" [UniProtKB:Q9BV68] xref: EMBL:AAH01442.1 xref: EMBL:AAH25374.1 xref: EMBL:BAA91254.1 xref: UniProtKB:Q9BV68 xref: UniProtKB:Q9NWX1 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014172 ! RNF126_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008682 ! rnf126-ube2d1 physical interaction [Term] id: CCO:B0043419 name: BBS2_HUMAN def: "Bardet-Biedl syndrome 2 protein" [UniProtKB:Q9BXC9] xref: EMBL:AAH14140.1 xref: EMBL:AAK28552.1 xref: EMBL:BAB55252.1 xref: UniProtKB:Q96CM0 xref: UniProtKB:Q96SN9 xref: UniProtKB:Q9BXC9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014149 ! BBS2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008683 ! bbs2-psme3 physical interaction [Term] id: CCO:B0043420 name: SERF2_HUMAN def: "Small EDRK-rich factor 2" [UniProtKB:P84101] synonym: "4F5rel" EXACT [UniProtKB:P84101] synonym: "Gastric cancer-related protein VRG107" EXACT [UniProtKB:P84101] synonym: "h4F5rel" EXACT [UniProtKB:P84101] xref: EMBL:AAC63516.1 xref: EMBL:AAH15491.2 xref: EMBL:AAK07636.1 xref: UniProtKB:O75918 xref: UniProtKB:O88891 xref: UniProtKB:P84101 xref: UniProtKB:Q9BZH7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014177 ! SERF2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008684 ! psme3-serf2 physical interaction [Term] id: CCO:B0043421 name: TNNT1_HUMAN def: "Troponin T, slow skeletal muscle" [UniProtKB:P13805] synonym: "Slow skeletal muscle troponin T" EXACT [UniProtKB:P13805] synonym: "sTnT" EXACT [UniProtKB:P13805] synonym: "TnTs" EXACT [UniProtKB:P13805] xref: EMBL:AAA61204.1 xref: EMBL:AAA61205.1 xref: EMBL:AAB30272.1 xref: EMBL:AAB30273.1 xref: EMBL:AAD13978.1 xref: EMBL:AAH10963.1 xref: EMBL:AAH22086.2 xref: EMBL:AAH34143.1 xref: EMBL:CAA09750.1 xref: EMBL:CAA09751.1 xref: EMBL:CAA09752.1 xref: UniProtKB:O95472 xref: UniProtKB:P13805 xref: UniProtKB:Q16061 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014178 ! TNNT1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008687 ! psmc5-tnnt1 physical interaction relationship: transforms_into CCO:B0043493 ! TNNT1_HUMAN-N-acetylserine2 relationship: transforms_into CCO:B0043494 ! TNNT1_HUMAN-Phosphoserine2 [Term] id: CCO:B0043422 name: CA216_HUMAN def: "UPF0500 protein C1orf216" [UniProtKB:Q8TAB5] xref: EMBL:AAH26909.1 xref: EMBL:BAC04755.1 xref: EMBL:BAC04799.1 xref: EMBL:EAX07403.1 xref: UniProtKB:Q8N8N6 xref: UniProtKB:Q8TAB5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014150 ! C1orf216_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008689 ! flj38984-psmc6 physical interaction [Term] id: CCO:B0043423 name: RASF8_HUMAN def: "Ras association domain-containing protein 8" [UniProtKB:Q8NHQ8] synonym: "Carcinoma-associated protein HOJ-1" EXACT [UniProtKB:Q8NHQ8] xref: EMBL:AAC95425.1 xref: EMBL:AAH30021.1 xref: EMBL:AAV54603.1 xref: EMBL:BAC98838.1 xref: UniProtKB:O95647 xref: UniProtKB:Q5SCI2 xref: UniProtKB:Q76KB6 xref: UniProtKB:Q8NHQ8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014168 ! RASSF8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008690 ! c12orf2-psmd4 physical interaction [Term] id: CCO:B0043424 name: KCD17_HUMAN def: "BTB/POZ domain-containing protein KCTD17" [UniProtKB:Q8N5Z5] xref: EMBL:AAH25403.1 xref: EMBL:AAH31038.1 xref: EMBL:BAB14007.1 xref: EMBL:CAA18441.1 xref: UniProtKB:O95517 xref: UniProtKB:Q8N5Z5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014164 ! KCTD17_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008692 ! kctd17-psma1 physical interaction [Term] id: CCO:B0043425 name: IP3KB_HUMAN def: "Inositol-trisphosphate 3-kinase B" [UniProtKB:P27987] synonym: "EC 2.7.1.127" EXACT [UniProtKB:P27987] synonym: "Inositol 1,4,5-trisphosphate 3-kinase B" EXACT [UniProtKB:P27987] synonym: "IP3 3-kinase B" EXACT [UniProtKB:P27987] synonym: "IP3K B" EXACT [UniProtKB:P27987] synonym: "IP3K-B" EXACT [UniProtKB:P27987] xref: EMBL:AAH15009.1 xref: EMBL:CAA40491.1 xref: EMBL:CAB65055.3 xref: EMBL:CAC40650.1 xref: EMBL:CAH70187.1 xref: EMBL:CAH70188.1 xref: UniProtKB:P27987 xref: UniProtKB:Q5VWL9 xref: UniProtKB:Q5VWM0 xref: UniProtKB:Q96BZ2 xref: UniProtKB:Q96JS1 xref: UniProtKB:Q9UH47 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014163 ! ITPKB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008693 ! itpkb-psme3 physical interaction relationship: transforms_into CCO:B0043470 ! IP3KB_HUMAN-Phosphoserine43 relationship: transforms_into CCO:B0043471 ! IP3KB_HUMAN-Phosphoserine49 [Term] id: CCO:B0043426 name: TRIM9_HUMAN def: "Tripartite motif-containing protein 9" [UniProtKB:Q9C026] synonym: "RING finger protein 91" EXACT [UniProtKB:Q9C026] xref: EMBL:AAG53490.1 xref: EMBL:AAG53491.1 xref: EMBL:AAG53492.1 xref: EMBL:AAH13414.1 xref: EMBL:AAH63872.1 xref: EMBL:BAA13398.2 xref: EMBL:BAB70913.1 xref: UniProtKB:Q92557 xref: UniProtKB:Q96D24 xref: UniProtKB:Q96NI4 xref: UniProtKB:Q9C025 xref: UniProtKB:Q9C026 xref: UniProtKB:Q9C027 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014180 ! TRIM9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008695 ! btrc-trim9 physical interaction [Term] id: CCO:B0043427 name: PSME2_HUMAN def: "Proteasome activator complex subunit 2" [UniProtKB:Q9UL46] synonym: "11S regulator complex subunit beta" EXACT [UniProtKB:Q9UL46] synonym: "Activator of multicatalytic protease subunit 2" EXACT [UniProtKB:Q9UL46] synonym: "PA28b" EXACT [UniProtKB:Q9UL46] synonym: "PA28beta" EXACT [UniProtKB:Q9UL46] synonym: "Proteasome activator 28 subunit beta" EXACT [UniProtKB:Q9UL46] synonym: "REG-beta" EXACT [UniProtKB:Q9UL46] xref: EMBL:AAF02218.1 xref: EMBL:AAH04368.1 xref: EMBL:AAH19885.1 xref: EMBL:AAH72025.1 xref: EMBL:BAA08205.1 xref: UniProtKB:Q15129 xref: UniProtKB:Q9UL46 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014167 ! PSME2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008698 ! psme1-psme2 physical interaction relationship: transforms_into CCO:B0043477 ! PSME2_HUMAN-N-acetylalanine2 [Term] id: CCO:B0043428 name: NCOA3_HUMAN def: "Nuclear receptor coactivator 3" [UniProtKB:Q9Y6Q9] synonym: "ACTR" EXACT [UniProtKB:Q9Y6Q9] synonym: "AIB-1" EXACT [UniProtKB:Q9Y6Q9] synonym: "Amplified in breast cancer-1 protein" EXACT [UniProtKB:Q9Y6Q9] synonym: "CBP-interacting protein" EXACT [UniProtKB:Q9Y6Q9] synonym: "EC 2.3.1.48" EXACT [UniProtKB:Q9Y6Q9] synonym: "NCoA-3" EXACT [UniProtKB:Q9Y6Q9] synonym: "pCIP" EXACT [UniProtKB:Q9Y6Q9] synonym: "RAC-3" EXACT [UniProtKB:Q9Y6Q9] synonym: "Receptor-associated coactivator 3" EXACT [UniProtKB:Q9Y6Q9] synonym: "SRC-3" EXACT [UniProtKB:Q9Y6Q9] synonym: "Steroid receptor coactivator protein 3" EXACT [UniProtKB:Q9Y6Q9] synonym: "Thyroid hormone receptor activator molecule 1" EXACT [UniProtKB:Q9Y6Q9] synonym: "TRAM-1" EXACT [UniProtKB:Q9Y6Q9] xref: EMBL:AAB92368.1 xref: EMBL:AAC51663.1 xref: EMBL:AAC51677.1 xref: EMBL:AAC51849.1 xref: EMBL:CAB40662.1 xref: EMBL:CAC17693.1 xref: EMBL:CAI42141.1 xref: UniProtKB:Q5JYD9 xref: UniProtKB:Q5JYE0 xref: UniProtKB:Q9BR49 xref: UniProtKB:Q9UPC9 xref: UniProtKB:Q9UPG4 xref: UniProtKB:Q9UPG7 xref: UniProtKB:Q9Y6Q9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014165 ! NCOA3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008700 ! ncoa3-psme3-2 physical interaction relationship: participates_in CCO:I0008702 ! ncoa3-psme3 physical interaction relationship: participates_in CCO:I0008769 ! ncoa3-psme3-1 physical interaction relationship: participates_in CCO:I0008790 ! ncoa3-psme3-3 direct interaction relationship: participates_in CCO:I0008791 ! ncoa3-psme3-4 direct interaction relationship: transforms_into CCO:B0043472 ! NCOA3_HUMAN-N6-acetyllysine616 relationship: transforms_into CCO:B0043473 ! NCOA3_HUMAN-N6-acetyllysine619 relationship: transforms_into CCO:B0043474 ! NCOA3_HUMAN-N6-acetyllysine620 relationship: transforms_into CCO:B0043475 ! NCOA3_HUMAN-Phosphoserine857 relationship: transforms_into CCO:B0043476 ! NCOA3_HUMAN-Phosphoserine867 [Term] id: CCO:B0043429 name: XRN2_HUMAN def: "5'-3' exoribonuclease 2" [UniProtKB:Q9H0D6] synonym: "DHM1-like protein" EXACT [UniProtKB:Q9H0D6] synonym: "DHP protein" EXACT [UniProtKB:Q9H0D6] synonym: "EC 3.1.13.-" EXACT [UniProtKB:Q9H0D6] xref: EMBL:AAD55138.1 xref: EMBL:AAH06417.2 xref: EMBL:AAQ13577.1 xref: EMBL:AAR24369.1 xref: EMBL:BAA90934.1 xref: EMBL:CAB66775.1 xref: EMBL:CAH71495.1 xref: EMBL:CAI19756.1 xref: UniProtKB:Q3L8N4 xref: UniProtKB:Q6KGZ9 xref: UniProtKB:Q9BQL1 xref: UniProtKB:Q9H0D6 xref: UniProtKB:Q9NTW0 xref: UniProtKB:Q9NXS6 xref: UniProtKB:Q9UL53 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014182 ! XRN2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008723 ! xrn2-psma3 physical interaction relationship: transforms_into CCO:B0043504 ! XRN2_HUMAN-Phosphoserine448 relationship: transforms_into CCO:B0043505 ! XRN2_HUMAN-Phosphoserine455 relationship: transforms_into CCO:B0043506 ! XRN2_HUMAN-Phosphoserine499 relationship: transforms_into CCO:B0043507 ! XRN2_HUMAN-Phosphoserine501 [Term] id: CCO:B0043430 name: RNF5_HUMAN def: "E3 ubiquitin-protein ligase RNF5" [UniProtKB:Q99942] synonym: "EC 6.3.2.-" EXACT [UniProtKB:Q99942] synonym: "HsRma1" EXACT [UniProtKB:Q99942] synonym: "Protein G16" EXACT [UniProtKB:Q99942] synonym: "RING finger protein 5" EXACT [UniProtKB:Q99942] xref: EMBL:AAB47492.1 xref: EMBL:AAH04155.1 xref: EMBL:AAI11393.1 xref: EMBL:AAI19742.1 xref: EMBL:AAI19743.1 xref: EMBL:AAI27652.1 xref: EMBL:AAI27653.1 xref: EMBL:AAP35769.1 xref: EMBL:BAB39359.1 xref: EMBL:CAB51286.1 xref: EMBL:CAI17532.1 xref: EMBL:CAI18351.1 xref: EMBL:CAI41808.1 xref: UniProtKB:Q0VDB7 xref: UniProtKB:Q99942 xref: UniProtKB:Q9UMQ2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014173 ! RNF5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008771 ! hsrma1-ube2e1 physical interaction [Term] id: CCO:B0043431 name: FBXL7_HUMAN def: "F-box/LRR-repeat protein 7" [UniProtKB:Q9UJT9] synonym: "F-box and leucine-rich repeat protein 7" EXACT [UniProtKB:Q9UJT9] synonym: "F-box protein FBL6/FBL7" EXACT [UniProtKB:Q9UJT9] xref: EMBL:AAF04514.1 xref: EMBL:AAF09248.1 xref: EMBL:AAH75061.1 xref: EMBL:BAA74863.2 xref: UniProtKB:O94926 xref: UniProtKB:Q9UJT9 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014158 ! FBXL7_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008774 ! fbxl7-skp1 physical interaction [Term] id: CCO:B0043432 name: FBXW2_HUMAN def: "F-box/WD repeat-containing protein 2" [UniProtKB:Q9UKT8] synonym: "F-box and WD-40 domain-containing protein 2" EXACT [UniProtKB:Q9UKT8] synonym: "Protein MD6" EXACT [UniProtKB:Q9UKT8] xref: EMBL:AAF04465.1 xref: EMBL:AAF13226.1 xref: EMBL:AAH18738.1 xref: EMBL:AAI10335.1 xref: EMBL:AAP97276.1 xref: EMBL:AAP97280.1 xref: EMBL:BAB14051.1 xref: EMBL:CAI95113.1 xref: UniProtKB:Q4VXH2 xref: UniProtKB:Q7Z4V6 xref: UniProtKB:Q8WV51 xref: UniProtKB:Q9HA09 xref: UniProtKB:Q9UKA3 xref: UniProtKB:Q9UKT8 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014159 ! FBXW2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008775 ! fbxl2-skp1 physical interaction [Term] id: CCO:B0043433 name: FBXW5_HUMAN def: "F-box/WD repeat-containing protein 5" [UniProtKB:Q969U6] synonym: "F-box and WD-40 domain-containing protein 5" EXACT [UniProtKB:Q969U6] xref: EMBL:AAG17240.1 xref: EMBL:AAG23772.1 xref: EMBL:AAH00850.1 xref: EMBL:AAH04541.2 xref: EMBL:AAH09429.1 xref: EMBL:AAH14130.1 xref: EMBL:AAH14297.1 xref: EMBL:BAB15354.1 xref: EMBL:CAB70851.1 xref: EMBL:CAI12741.1 xref: EMBL:CAI12743.1 xref: EMBL:CAI12746.1 xref: UniProtKB:Q5SPZ8 xref: UniProtKB:Q5SPZ9 xref: UniProtKB:Q5SQ02 xref: UniProtKB:Q5SQ03 xref: UniProtKB:Q5SQ04 xref: UniProtKB:Q8WY79 xref: UniProtKB:Q969U6 xref: UniProtKB:Q96GJ6 xref: UniProtKB:Q9BSU8 xref: UniProtKB:Q9H6A8 xref: UniProtKB:Q9HBQ6 xref: UniProtKB:Q9NSZ3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014160 ! FBXW5_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008776 ! fbw5-skp1 physical interaction [Term] id: CCO:B0043434 name: FBXW8_HUMAN def: "F-box/WD repeat-containing protein 8" [UniProtKB:Q8N3Y1] synonym: "F-box and WD-40 domain-containing protein 8" EXACT [UniProtKB:Q8N3Y1] synonym: "F-box only protein 29" EXACT [UniProtKB:Q8N3Y1] xref: EMBL:AAF03129.1 xref: EMBL:AAH37296.1 xref: UniProtKB:Q8N3Y1 xref: UniProtKB:Q9UK95 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014161 ! FBXW8_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008777 ! fbw6-skp1 physical interaction relationship: transforms_into CCO:B0043469 ! FBXW8_HUMAN-Phosphoserine85 [Term] id: CCO:B0043435 name: FBX41_HUMAN def: "F-box only protein 41" [UniProtKB:Q8TF61] xref: EMBL:BAB85526.1 xref: UniProtKB:Q8TF61 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014157 ! FBXO41_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008779 ! fbxo41-skp1 physical interaction relationship: transforms_into CCO:B0043463 ! FBX41_HUMAN-N-acetylalanine2 relationship: transforms_into CCO:B0043464 ! FBX41_HUMAN-Phosphoserine3 relationship: transforms_into CCO:B0043465 ! FBX41_HUMAN-Phosphoserine21 relationship: transforms_into CCO:B0043466 ! FBX41_HUMAN-Phosphoserine478 relationship: transforms_into CCO:B0043467 ! FBX41_HUMAN-Phosphothreonine479 relationship: transforms_into CCO:B0043468 ! FBX41_HUMAN-Phosphoserine547 [Term] id: CCO:B0043436 name: PRIO_HUMAN def: "Major prion protein precursor" [UniProtKB:P04156] synonym: "ASCR" EXACT [UniProtKB:P04156] synonym: "CD230 antigen" EXACT [UniProtKB:P04156] synonym: "PrP" EXACT [UniProtKB:P04156] synonym: "PrP27-30" EXACT [UniProtKB:P04156] synonym: "PrP33-35C" EXACT [UniProtKB:P04156] xref: EMBL:AAA19664.1 xref: EMBL:AAA60182.1 xref: EMBL:AAB20521.1 xref: EMBL:AAB20522.1 xref: EMBL:AAB20523.1 xref: EMBL:AAB50648.2 xref: EMBL:AAB50649.2 xref: EMBL:AAB59442.1 xref: EMBL:AAB59443.1 xref: EMBL:AAC05365.1 xref: EMBL:AAC78725.1 xref: EMBL:AAD46098.1 xref: EMBL:AAG21693.1 xref: EMBL:AAH12844.1 xref: EMBL:AAH22532.1 xref: EMBL:ABD63004.1 xref: EMBL:BAA00011.1 xref: EMBL:CAA58442.1 xref: EMBL:CAB75503.1 xref: UniProtKB:O60489 xref: UniProtKB:P04156 xref: UniProtKB:P78446 xref: UniProtKB:Q15216 xref: UniProtKB:Q15221 xref: UniProtKB:Q27H91 xref: UniProtKB:Q8TBG0 xref: UniProtKB:Q96E70 xref: UniProtKB:Q9UP19 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014166 ! PRNP_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008787 ! prnp-psma3 physical interaction [Term] id: CCO:B0043437 name: RERE_HUMAN def: "Arginine-glutamic acid dipeptide repeats protein" [UniProtKB:Q9P2R6] synonym: "Atrophin-1-like protein" EXACT [UniProtKB:Q9P2R6] synonym: "Atrophin-1-related protein" EXACT [UniProtKB:Q9P2R6] xref: EMBL:AAC28264.1 xref: EMBL:AAC31120.1 xref: EMBL:AAD27584.1 xref: EMBL:BAA32303.3 xref: EMBL:BAA95898.1 xref: EMBL:CAH70516.1 xref: EMBL:CAH73433.1 xref: EMBL:CAI19208.1 xref: UniProtKB:O43393 xref: UniProtKB:O75046 xref: UniProtKB:O75359 xref: UniProtKB:Q5VXL9 xref: UniProtKB:Q6P6B9 xref: UniProtKB:Q9P2R6 xref: UniProtKB:Q9Y2W4 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014170 ! RERE_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008788 ! rere-psma3 physical interaction relationship: participates_in CCO:I0008789 ! rere-psma3-1 physical interaction relationship: transforms_into CCO:B0043484 ! RERE_HUMAN-Phosphoserine594 relationship: transforms_into CCO:B0043485 ! RERE_HUMAN-Phosphothreonine599 relationship: transforms_into CCO:B0043486 ! RERE_HUMAN-Phosphoserine600 relationship: transforms_into CCO:B0043487 ! RERE_HUMAN-Phosphoserine613 relationship: transforms_into CCO:B0043488 ! RERE_HUMAN-Phosphoserine656 relationship: transforms_into CCO:B0043489 ! RERE_HUMAN-Phosphoserine675 relationship: transforms_into CCO:B0043490 ! RERE_HUMAN-Phosphoserine679 [Term] id: CCO:B0043438 name: RUXF_HUMAN def: "Small nuclear ribonucleoprotein F" [UniProtKB:P62306] synonym: "Sm protein F" EXACT [UniProtKB:P62306] synonym: "Sm-F" EXACT [UniProtKB:P62306] synonym: "SmF" EXACT [UniProtKB:P62306] synonym: "snRNP-F" EXACT [UniProtKB:P62306] xref: EMBL:AAH02505.3 xref: EMBL:AAH63397.2 xref: EMBL:AAI28453.1 xref: EMBL:AAI28454.1 xref: EMBL:CAA59688.1 xref: EMBL:CAG33032.1 xref: UniProtKB:A2VCR2 xref: UniProtKB:P62306 xref: UniProtKB:Q15356 xref: UniProtKB:Q6IBQ1 xref: UniProtKB:Q6P4I0 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014176 ! SNRPF_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008797 ! snrpf-psma3 physical interaction [Term] id: CCO:B0043439 name: VINC_HUMAN def: "Vinculin" [UniProtKB:P18206] synonym: "Metavinculin" EXACT [UniProtKB:P18206] xref: EMBL:AAA61271.1 xref: EMBL:AAA61283.1 xref: EMBL:AAB21656.1 xref: EMBL:AAB21657.1 xref: EMBL:AAH39174.1 xref: EMBL:CAD97952.1 xref: EMBL:CAI13972.1 xref: EMBL:CAI39673.1 xref: UniProtKB:P18206 xref: UniProtKB:Q16450 xref: UniProtKB:Q5SWX2 xref: UniProtKB:Q7Z3B8 xref: UniProtKB:Q8IXU7 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014181 ! VCL_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008799 ! psme1-vcl physical interaction relationship: transforms_into CCO:B0043496 ! VINC_HUMAN-Phosphoserine290 relationship: transforms_into CCO:B0043497 ! VINC_HUMAN-Phosphothreonine324 relationship: transforms_into CCO:B0043498 ! VINC_HUMAN-Phosphothreonine508 relationship: transforms_into CCO:B0043499 ! VINC_HUMAN-Phosphotyrosine537 relationship: transforms_into CCO:B0043500 ! VINC_HUMAN-Phosphothreonine604 relationship: transforms_into CCO:B0043501 ! VINC_HUMAN-Phosphoserine721 relationship: transforms_into CCO:B0043502 ! VINC_HUMAN-Phosphoserine774 relationship: transforms_into CCO:B0043503 ! VINC_HUMAN-Phosphotyrosine822 [Term] id: CCO:B0043440 name: RSMB_HUMAN def: "Small nuclear ribonucleoprotein-associated proteins B and B'" [UniProtKB:P14678] synonym: "Sm protein B/B'" EXACT [UniProtKB:P14678] synonym: "Sm-B/Sm-B'" EXACT [UniProtKB:P14678] synonym: "SmB/SmB'" EXACT [UniProtKB:P14678] synonym: "snRNP-B" EXACT [UniProtKB:P14678] xref: EMBL:AAA36578.1 xref: EMBL:AAA36579.1 xref: EMBL:AAD54488.1 xref: EMBL:CAA33902.1 xref: EMBL:CAA37170.1 xref: EMBL:CAA37171.1 xref: EMBL:CAB46714.1 xref: EMBL:CAB46715.1 xref: EMBL:CAB57867.1 xref: EMBL:CAB57868.1 xref: UniProtKB:P14678 xref: UniProtKB:Q15490 xref: UniProtKB:Q9UIS5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014174 ! SNRPB_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008802 ! snrpb-psma3 physical interaction relationship: transforms_into CCO:B0043491 ! RSMB_HUMAN-Omega-N-methylated arginine108 relationship: transforms_into CCO:B0043492 ! RSMB_HUMAN-Omega-N-methylated arginine112 [Term] id: CCO:B0043441 name: EZH2_HUMAN def: "Enhancer of zeste homolog 2" [UniProtKB:Q15910] synonym: "ENX-1" EXACT [UniProtKB:Q15910] synonym: "Lysine N-methyltransferase 6" EXACT [UniProtKB:Q15910] xref: EMBL:AAC50591.1 xref: EMBL:AAC51520.1 xref: EMBL:CAA64955.1 xref: UniProtKB:Q15755 xref: UniProtKB:Q15910 xref: UniProtKB:Q92857 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014155 ! EZH2_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008804 ! ezh2-psmb6 physical interaction relationship: transforms_into CCO:B0043461 ! EZH2_HUMAN-Phosphoserine380 relationship: transforms_into CCO:B0043462 ! EZH2_HUMAN-Phosphothreonine487 [Term] id: CCO:B0043442 name: FBX34_HUMAN def: "F-box only protein 34" [UniProtKB:Q9NWN3] xref: EMBL:AAI09121.1 xref: EMBL:AAI09122.1 xref: EMBL:BAA91346.1 xref: EMBL:CAD62596.1 xref: EMBL:CAG33530.1 xref: UniProtKB:Q2VPB5 xref: UniProtKB:Q86TY4 xref: UniProtKB:Q9NWN3 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014156 ! FBXO34_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008805 ! fbxo34-skp1a physical interaction relationship: participates_in CCO:I0008806 ! skp1a-fbxo34 physical interaction [Term] id: CCO:B0043443 name: CENA1_HUMAN def: "Centaurin-alpha-1" [UniProtKB:O75689] synonym: "Putative MAPK-activating protein PM25" EXACT [UniProtKB:O75689] xref: EMBL:AAD11414.1 xref: EMBL:AAH33747.1 xref: EMBL:BAC77402.1 xref: EMBL:CAA07024.1 xref: UniProtKB:O75689 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014152 ! CENTA1_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008809 ! psme3-centa1 physical interaction relationship: transforms_into CCO:B0043459 ! CENA1_HUMAN-Phosphoserine87 relationship: transforms_into CCO:B0043460 ! CENA1_HUMAN-Phosphothreonine276 [Term] id: CCO:B0043444 name: CBWD3_HUMAN def: "COBW domain-containing protein 3" [UniProtKB:Q5JTY5] synonym: "Cobalamin synthetase W domain-containing protein 3" EXACT [UniProtKB:Q5JTY5] xref: EMBL:CAI41162.1 xref: UniProtKB:Q5JTY5 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014151 ! CBWD3_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008812 ! ube2e1-cbwd3 physical interaction [Term] id: CCO:B0043445 name: HEXA_HUMAN def: "Beta-hexosaminidase subunit alpha precursor" [UniProtKB:P06865] synonym: "Beta-N-acetylhexosaminidase subunit alpha" EXACT [UniProtKB:P06865] synonym: "EC 3.2.1.52" EXACT [UniProtKB:P06865] synonym: "Hexosaminidase subunit A" EXACT [UniProtKB:P06865] synonym: "N-acetyl-beta-glucosaminidase subunit alpha" EXACT [UniProtKB:P06865] xref: EMBL:AAA51827.1 xref: EMBL:AAB00965.1 xref: EMBL:AAD13932.1 xref: EMBL:AAH18927.1 xref: EMBL:AAH84537.1 xref: UniProtKB:P06865 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014162 ! HEXA_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008814 ! usp22-hexa physical interaction [Term] id: CCO:B0043446 name: RM10_HUMAN def: "39S ribosomal protein L10, mitochondrial precursor" [UniProtKB:Q7Z7H8] synonym: "L10mt" EXACT [UniProtKB:Q7Z7H8] synonym: "MRP-L10" EXACT [UniProtKB:Q7Z7H8] xref: EMBL:AAH15904.1 xref: EMBL:AAH52601.1 xref: EMBL:BAB54946.1 xref: UniProtKB:Q7Z7H8 xref: UniProtKB:Q96B80 xref: UniProtKB:Q96Q55 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014171 ! MRPL10_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008815 ! usp22-mrpl10 physical interaction [Term] id: CCO:B0043447 name: DD19B_HUMAN def: "ATP-dependent RNA helicase DDX19B" [UniProtKB:Q9UMR2] synonym: "DEAD box protein 19B" EXACT [UniProtKB:Q9UMR2] synonym: "DEAD box RNA helicase DEAD5" EXACT [UniProtKB:Q9UMR2] synonym: "EC 3.6.1.-" EXACT [UniProtKB:Q9UMR2] xref: EMBL:AAH03626.1 xref: EMBL:CAB52189.1 xref: EMBL:CAB66574.1 xref: EMBL:CAG33496.1 xref: EMBL:CAG38540.1 xref: EMBL:EAW51834.1 xref: UniProtKB:Q6FIB7 xref: UniProtKB:Q6IAE0 xref: UniProtKB:Q9H0U0 xref: UniProtKB:Q9UMR2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014154 ! DDX19B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008820 ! ddx19b-skp1a physical interaction [Term] id: CCO:B0043448 name: RT09_HUMAN def: "28S ribosomal protein S9, mitochondrial precursor" [UniProtKB:P82933] synonym: "MRP-S9" EXACT [UniProtKB:P82933] synonym: "S9mt" EXACT [UniProtKB:P82933] xref: UniProtKB:P82933 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014175 ! MRPS9_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008821 ! mrps9-ccndbp1 physical interaction [Term] id: CCO:B0043449 name: Q75LH2_HUMAN def: "Putative uncharacterized protein FLJ10324" [UniProtKB:Q75LH2] xref: EMBL:AAS07560.1 xref: UniProtKB:Q75LH2 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014183 ! FLJ10324_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008822 ! psmd14-flj10324 physical interaction [Term] id: CCO:B0043450 name: RB15B_HUMAN def: "Putative RNA-binding protein 15B" [UniProtKB:Q8NDT2] synonym: "RNA-binding motif protein 15B" EXACT [UniProtKB:Q8NDT2] xref: EMBL:AAH01367.2 xref: EMBL:AAS50153.1 xref: EMBL:CAD38547.2 xref: UniProtKB:Q6QE19 xref: UniProtKB:Q8NDT2 xref: UniProtKB:Q9BV96 is_a: CCO:U0000007 ! cell cycle protein relationship: encoded_by CCO:G0014169 ! RBM15B_human relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: participates_in CCO:I0008823 ! psmd14-rbm15b physical interaction relationship: transforms_into CCO:B0043478 ! RB15B_HUMAN-Phosphothreonine205 relationship: transforms_into CCO:B0043479 ! RB15B_HUMAN-Phosphoserine225 relationship: transforms_into CCO:B0043480 ! RB15B_HUMAN-Phosphoserine271 relationship: transforms_into CCO:B0043481 ! RB15B_HUMAN-Phosphoserine273 relationship: transforms_into CCO:B0043482 ! RB15B_HUMAN-Phosphoserine274 relationship: transforms_into CCO:B0043483 ! RB15B_HUMAN-Phosphoserine282 [Term] id: CCO:B0043459 name: CENA1_HUMAN-Phosphoserine87 def: "Protein CENA1_HUMAN with the residue 87 substituted with Phosphoserine" [UniProtKB:O75689] comment: by PKC; xref: UniProtKB:O75689 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043443 ! CENA1_HUMAN [Term] id: CCO:B0043460 name: CENA1_HUMAN-Phosphothreonine276 def: "Protein CENA1_HUMAN with the residue 276 substituted with Phosphothreonine" [UniProtKB:O75689] comment: by PKC; xref: UniProtKB:O75689 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043443 ! CENA1_HUMAN [Term] id: CCO:B0043461 name: EZH2_HUMAN-Phosphoserine380 def: "Protein EZH2_HUMAN with the residue 380 substituted with Phosphoserine" [UniProtKB:Q15910] xref: UniProtKB:Q15910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043441 ! EZH2_HUMAN [Term] id: CCO:B0043462 name: EZH2_HUMAN-Phosphothreonine487 def: "Protein EZH2_HUMAN with the residue 487 substituted with Phosphothreonine" [UniProtKB:Q15910] xref: UniProtKB:Q15910 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043441 ! EZH2_HUMAN [Term] id: CCO:B0043463 name: FBX41_HUMAN-N-acetylalanine2 def: "Protein FBX41_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q8TF61] comment: By similarity xref: UniProtKB:Q8TF61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043435 ! FBX41_HUMAN [Term] id: CCO:B0043464 name: FBX41_HUMAN-Phosphoserine3 def: "Protein FBX41_HUMAN with the residue 3 substituted with Phosphoserine" [UniProtKB:Q8TF61] comment: By similarity xref: UniProtKB:Q8TF61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043435 ! FBX41_HUMAN [Term] id: CCO:B0043465 name: FBX41_HUMAN-Phosphoserine21 def: "Protein FBX41_HUMAN with the residue 21 substituted with Phosphoserine" [UniProtKB:Q8TF61] comment: By similarity xref: UniProtKB:Q8TF61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043435 ! FBX41_HUMAN [Term] id: CCO:B0043466 name: FBX41_HUMAN-Phosphoserine478 def: "Protein FBX41_HUMAN with the residue 478 substituted with Phosphoserine" [UniProtKB:Q8TF61] comment: By similarity xref: UniProtKB:Q8TF61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043435 ! FBX41_HUMAN [Term] id: CCO:B0043467 name: FBX41_HUMAN-Phosphothreonine479 def: "Protein FBX41_HUMAN with the residue 479 substituted with Phosphothreonine" [UniProtKB:Q8TF61] comment: By similarity xref: UniProtKB:Q8TF61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043435 ! FBX41_HUMAN [Term] id: CCO:B0043468 name: FBX41_HUMAN-Phosphoserine547 def: "Protein FBX41_HUMAN with the residue 547 substituted with Phosphoserine" [UniProtKB:Q8TF61] comment: By similarity xref: UniProtKB:Q8TF61 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043435 ! FBX41_HUMAN [Term] id: CCO:B0043469 name: FBXW8_HUMAN-Phosphoserine85 def: "Protein FBXW8_HUMAN with the residue 85 substituted with Phosphoserine" [UniProtKB:Q8N3Y1] comment: By similarity xref: UniProtKB:Q8N3Y1 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043434 ! FBXW8_HUMAN [Term] id: CCO:B0043470 name: IP3KB_HUMAN-Phosphoserine43 def: "Protein IP3KB_HUMAN with the residue 43 substituted with Phosphoserine" [UniProtKB:P27987] xref: UniProtKB:P27987 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043425 ! IP3KB_HUMAN [Term] id: CCO:B0043471 name: IP3KB_HUMAN-Phosphoserine49 def: "Protein IP3KB_HUMAN with the residue 49 substituted with Phosphoserine" [UniProtKB:P27987] xref: UniProtKB:P27987 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043425 ! IP3KB_HUMAN [Term] id: CCO:B0043472 name: NCOA3_HUMAN-N6-acetyllysine616 def: "Protein NCOA3_HUMAN with the residue 616 substituted with N6-acetyllysine" [UniProtKB:Q9Y6Q9] comment: by CREBBP; xref: UniProtKB:Q9Y6Q9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:B0043473 name: NCOA3_HUMAN-N6-acetyllysine619 def: "Protein NCOA3_HUMAN with the residue 619 substituted with N6-acetyllysine" [UniProtKB:Q9Y6Q9] comment: by CREBBP; xref: UniProtKB:Q9Y6Q9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:B0043474 name: NCOA3_HUMAN-N6-acetyllysine620 def: "Protein NCOA3_HUMAN with the residue 620 substituted with N6-acetyllysine" [UniProtKB:Q9Y6Q9] comment: by CREBBP; xref: UniProtKB:Q9Y6Q9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:B0043475 name: NCOA3_HUMAN-Phosphoserine857 def: "Protein NCOA3_HUMAN with the residue 857 substituted with Phosphoserine" [UniProtKB:Q9Y6Q9] xref: UniProtKB:Q9Y6Q9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:B0043476 name: NCOA3_HUMAN-Phosphoserine867 def: "Protein NCOA3_HUMAN with the residue 867 substituted with Phosphoserine" [UniProtKB:Q9Y6Q9] xref: UniProtKB:Q9Y6Q9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:B0043477 name: PSME2_HUMAN-N-acetylalanine2 def: "Protein PSME2_HUMAN with the residue 2 substituted with N-acetylalanine" [UniProtKB:Q9UL46] xref: UniProtKB:Q9UL46 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043427 ! PSME2_HUMAN [Term] id: CCO:B0043478 name: RB15B_HUMAN-Phosphothreonine205 def: "Protein RB15B_HUMAN with the residue 205 substituted with Phosphothreonine" [UniProtKB:Q8NDT2] xref: UniProtKB:Q8NDT2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043450 ! RB15B_HUMAN [Term] id: CCO:B0043479 name: RB15B_HUMAN-Phosphoserine225 def: "Protein RB15B_HUMAN with the residue 225 substituted with Phosphoserine" [UniProtKB:Q8NDT2] xref: UniProtKB:Q8NDT2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043450 ! RB15B_HUMAN [Term] id: CCO:B0043480 name: RB15B_HUMAN-Phosphoserine271 def: "Protein RB15B_HUMAN with the residue 271 substituted with Phosphoserine" [UniProtKB:Q8NDT2] xref: UniProtKB:Q8NDT2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043450 ! RB15B_HUMAN [Term] id: CCO:B0043481 name: RB15B_HUMAN-Phosphoserine273 def: "Protein RB15B_HUMAN with the residue 273 substituted with Phosphoserine" [UniProtKB:Q8NDT2] xref: UniProtKB:Q8NDT2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043450 ! RB15B_HUMAN [Term] id: CCO:B0043482 name: RB15B_HUMAN-Phosphoserine274 def: "Protein RB15B_HUMAN with the residue 274 substituted with Phosphoserine" [UniProtKB:Q8NDT2] xref: UniProtKB:Q8NDT2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043450 ! RB15B_HUMAN [Term] id: CCO:B0043483 name: RB15B_HUMAN-Phosphoserine282 def: "Protein RB15B_HUMAN with the residue 282 substituted with Phosphoserine" [UniProtKB:Q8NDT2] xref: UniProtKB:Q8NDT2 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043450 ! RB15B_HUMAN [Term] id: CCO:B0043484 name: RERE_HUMAN-Phosphoserine594 def: "Protein RERE_HUMAN with the residue 594 substituted with Phosphoserine" [UniProtKB:Q9P2R6] xref: UniProtKB:Q9P2R6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043437 ! RERE_HUMAN [Term] id: CCO:B0043485 name: RERE_HUMAN-Phosphothreonine599 def: "Protein RERE_HUMAN with the residue 599 substituted with Phosphothreonine" [UniProtKB:Q9P2R6] xref: UniProtKB:Q9P2R6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043437 ! RERE_HUMAN [Term] id: CCO:B0043486 name: RERE_HUMAN-Phosphoserine600 def: "Protein RERE_HUMAN with the residue 600 substituted with Phosphoserine" [UniProtKB:Q9P2R6] comment: By similarity xref: UniProtKB:Q9P2R6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043437 ! RERE_HUMAN [Term] id: CCO:B0043487 name: RERE_HUMAN-Phosphoserine613 def: "Protein RERE_HUMAN with the residue 613 substituted with Phosphoserine" [UniProtKB:Q9P2R6] xref: UniProtKB:Q9P2R6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043437 ! RERE_HUMAN [Term] id: CCO:B0043488 name: RERE_HUMAN-Phosphoserine656 def: "Protein RERE_HUMAN with the residue 656 substituted with Phosphoserine" [UniProtKB:Q9P2R6] xref: UniProtKB:Q9P2R6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043437 ! RERE_HUMAN [Term] id: CCO:B0043489 name: RERE_HUMAN-Phosphoserine675 def: "Protein RERE_HUMAN with the residue 675 substituted with Phosphoserine" [UniProtKB:Q9P2R6] comment: By similarity xref: UniProtKB:Q9P2R6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043437 ! RERE_HUMAN [Term] id: CCO:B0043490 name: RERE_HUMAN-Phosphoserine679 def: "Protein RERE_HUMAN with the residue 679 substituted with Phosphoserine" [UniProtKB:Q9P2R6] comment: By similarity xref: UniProtKB:Q9P2R6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043437 ! RERE_HUMAN [Term] id: CCO:B0043491 name: RSMB_HUMAN-Omega-N-methylated arginine108 def: "Protein RSMB_HUMAN with the residue 108 substituted with Omega-N-methylated arginine" [UniProtKB:P14678] xref: UniProtKB:P14678 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043440 ! RSMB_HUMAN [Term] id: CCO:B0043492 name: RSMB_HUMAN-Omega-N-methylated arginine112 def: "Protein RSMB_HUMAN with the residue 112 substituted with Omega-N-methylated arginine" [UniProtKB:P14678] xref: UniProtKB:P14678 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043440 ! RSMB_HUMAN [Term] id: CCO:B0043493 name: TNNT1_HUMAN-N-acetylserine2 def: "Protein TNNT1_HUMAN with the residue 2 substituted with N-acetylserine" [UniProtKB:P13805] comment: By similarity xref: UniProtKB:P13805 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043421 ! TNNT1_HUMAN [Term] id: CCO:B0043494 name: TNNT1_HUMAN-Phosphoserine2 def: "Protein TNNT1_HUMAN with the residue 2 substituted with Phosphoserine" [UniProtKB:P13805] comment: by CK2; By similarity xref: UniProtKB:P13805 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043421 ! TNNT1_HUMAN [Term] id: CCO:B0043495 name: TRI39_HUMAN-Phosphotyrosine439 def: "Protein TRI39_HUMAN with the residue 439 substituted with Phosphotyrosine" [UniProtKB:Q9HCM9] xref: UniProtKB:Q9HCM9 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043417 ! TRI39_HUMAN [Term] id: CCO:B0043496 name: VINC_HUMAN-Phosphoserine290 def: "Protein VINC_HUMAN with the residue 290 substituted with Phosphoserine" [UniProtKB:P18206] xref: UniProtKB:P18206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043439 ! VINC_HUMAN [Term] id: CCO:B0043497 name: VINC_HUMAN-Phosphothreonine324 def: "Protein VINC_HUMAN with the residue 324 substituted with Phosphothreonine" [UniProtKB:P18206] comment: By similarity xref: UniProtKB:P18206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043439 ! VINC_HUMAN [Term] id: CCO:B0043498 name: VINC_HUMAN-Phosphothreonine508 def: "Protein VINC_HUMAN with the residue 508 substituted with Phosphothreonine" [UniProtKB:P18206] xref: UniProtKB:P18206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043439 ! VINC_HUMAN [Term] id: CCO:B0043499 name: VINC_HUMAN-Phosphotyrosine537 def: "Protein VINC_HUMAN with the residue 537 substituted with Phosphotyrosine" [UniProtKB:P18206] comment: Potential xref: UniProtKB:P18206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043439 ! VINC_HUMAN [Term] id: CCO:B0043500 name: VINC_HUMAN-Phosphothreonine604 def: "Protein VINC_HUMAN with the residue 604 substituted with Phosphothreonine" [UniProtKB:P18206] xref: UniProtKB:P18206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043439 ! VINC_HUMAN [Term] id: CCO:B0043501 name: VINC_HUMAN-Phosphoserine721 def: "Protein VINC_HUMAN with the residue 721 substituted with Phosphoserine" [UniProtKB:P18206] xref: UniProtKB:P18206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043439 ! VINC_HUMAN [Term] id: CCO:B0043502 name: VINC_HUMAN-Phosphoserine774 def: "Protein VINC_HUMAN with the residue 774 substituted with Phosphoserine" [UniProtKB:P18206] comment: By similarity xref: UniProtKB:P18206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043439 ! VINC_HUMAN [Term] id: CCO:B0043503 name: VINC_HUMAN-Phosphotyrosine822 def: "Protein VINC_HUMAN with the residue 822 substituted with Phosphotyrosine" [UniProtKB:P18206] comment: Probable xref: UniProtKB:P18206 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043439 ! VINC_HUMAN [Term] id: CCO:B0043504 name: XRN2_HUMAN-Phosphoserine448 def: "Protein XRN2_HUMAN with the residue 448 substituted with Phosphoserine" [UniProtKB:Q9H0D6] xref: UniProtKB:Q9H0D6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043429 ! XRN2_HUMAN [Term] id: CCO:B0043505 name: XRN2_HUMAN-Phosphoserine455 def: "Protein XRN2_HUMAN with the residue 455 substituted with Phosphoserine" [UniProtKB:Q9H0D6] xref: UniProtKB:Q9H0D6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043429 ! XRN2_HUMAN [Term] id: CCO:B0043506 name: XRN2_HUMAN-Phosphoserine499 def: "Protein XRN2_HUMAN with the residue 499 substituted with Phosphoserine" [UniProtKB:Q9H0D6] xref: UniProtKB:Q9H0D6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043429 ! XRN2_HUMAN [Term] id: CCO:B0043507 name: XRN2_HUMAN-Phosphoserine501 def: "Protein XRN2_HUMAN with the residue 501 substituted with Phosphoserine" [UniProtKB:Q9H0D6] xref: UniProtKB:Q9H0D6 is_a: CCO:U0000011 ! cell cycle modified protein relationship: has_source CCO:T0000004 ! Homo sapiens organism relationship: transformation_of CCO:B0043429 ! XRN2_HUMAN [Term] id: CCO:C0000001 name: phosphopyruvate hydratase complex namespace: cellular_component def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "enolase complex" EXACT [] xref: GO:0000015 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000002 name: repairosome namespace: cellular_component def: "A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] xref: GO:0000108 is_a: CCO:C0000003 ! nucleotide-excision repair complex [Term] id: CCO:C0000003 name: nucleotide-excision repair complex namespace: cellular_component def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862] comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. subset: goslim_pir xref: GO:0000109 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000004 name: nucleotide-excision repair factor 1 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF1 complex" EXACT [] xref: GO:0000110 is_a: CCO:C0000003 ! nucleotide-excision repair complex [Term] id: CCO:C0000005 name: nucleotide-excision repair factor 2 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF2 complex" EXACT [] xref: GO:0000111 is_a: CCO:C0000003 ! nucleotide-excision repair complex [Term] id: CCO:C0000006 name: nucleotide-excision repair factor 3 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p)." [PMID:10915862, PMID:14500720, PMID:7813015] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF3 complex" EXACT [] xref: GO:0000112 is_a: CCO:C0000003 ! nucleotide-excision repair complex [Term] id: CCO:C0000007 name: nucleotide-excision repair factor 4 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF4 complex" EXACT [] xref: GO:0000113 is_a: CCO:C0000003 ! nucleotide-excision repair complex [Term] id: CCO:C0000008 name: histone deacetylase complex namespace: cellular_component def: "A protein complex that possesses histone deacetylase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. synonym: "HDAC complex" EXACT [] xref: GO:0000118 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part relationship: location_of CCO:B0012169 ! HDAC6_HUMAN-Phosphothreonine30 [Term] id: CCO:C0000009 name: mediator complex namespace: cellular_component def: "A protein complex that enables the RNA polymerase II-general RNA polymerase II transcription factor complex to react to transcriptional activator proteins; also enhances the level of basal transcription." [PMID:10384286, PMID:11114191, PMID:8187178, PMID:9396788, PMID:9774831] synonym: "S mediator complex" EXACT [] synonym: "TRAP complex" NARROW [] xref: GO:0000119 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0000010 name: RNA polymerase I transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah] xref: GO:0000120 is_a: CCO:C0000272 ! transcription factor complex is_a: CCO:C0001871 ! nucleolar part [Term] id: CCO:C0000011 name: histone acetyltransferase complex namespace: cellular_component def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "histone acetylase complex" EXACT [] xref: GO:0000123 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part relationship: location_of CCO:B0011705 ! EP300_HUMAN-Omega-N-methylated arginine604 [Term] id: CCO:C0000012 name: SAGA complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607] synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT [] xref: GO:0000124 is_a: CCO:C0000011 ! histone acetyltransferase complex relationship: location_of CCO:B0024005 ! UBP22_HUMAN [Term] id: CCO:C0000013 name: PCAF complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. xref: GO:0000125 is_a: CCO:C0000011 ! histone acetyltransferase complex [Term] id: CCO:C0000014 name: transcription factor TFIIIB complex namespace: cellular_component def: "A transcription factor for eukaryotic RNA polymerase III promoters that is an RNA polymerase binding protein." [GOC:mah, ISBN:0198547684] xref: GO:0000126 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0000015 name: transcription factor TFIIIC complex namespace: cellular_component def: "A heterotrimeric transcription factor for eukaryotic RNA polymerase III promoters." [GOC:mah, ISBN:0198547684] xref: GO:0000127 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0000016 name: incipient cellular bud site namespace: cellular_component def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt] xref: GO:0000131 is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000017 name: polarisome namespace: cellular_component def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790] subset: goslim_pir xref: GO:0000133 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001867 ! cell cortex part relationship: part_of CCO:C0001007 ! site of polarized growth [Term] id: CCO:C0000018 name: alpha-1,6-mannosyltransferase complex namespace: cellular_component def: "A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735] xref: GO:0000136 is_a: CCO:C0001276 ! mannosyltransferase complex is_a: CCO:C0001850 ! Golgi apparatus part relationship: part_of CCO:C0000019 ! Golgi cis cisterna [Term] id: CCO:C0000019 name: Golgi cis cisterna namespace: cellular_component def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] xref: GO:0000137 is_a: CCO:C0001377 ! Golgi cisterna [Term] id: CCO:C0000020 name: Golgi trans cisterna namespace: cellular_component def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] xref: GO:0000138 is_a: CCO:C0001377 ! Golgi cisterna [Term] id: CCO:C0000021 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] xref: GO:0000139 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001850 ! Golgi apparatus part relationship: location_of CCO:B0001806 ! DHC24_HUMAN relationship: location_of CCO:B0002175 ! NSMA2_HUMAN relationship: part_of CCO:C0000733 ! endomembrane system [Term] id: CCO:C0000022 name: cellular bud neck contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis." [GOC:krc, PMID:16009555] synonym: "actomyosin ring (sensu Saccharomyces)" BROAD [] synonym: "contractile ring (sensu Saccharomyces)" EXACT [] synonym: "cytokinetic ring (sensu Saccharomyces)" BROAD [] synonym: "neck ring" EXACT [] xref: GO:0000142 is_a: CCO:C0000394 ! contractile ring relationship: part_of CCO:C0000487 ! cellular bud neck [Term] id: CCO:C0000023 name: cellular bud neck septin ring namespace: cellular_component def: "A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555] synonym: "septin ring (sensu Saccharomyces)" EXACT [] xref: GO:0000144 is_a: CCO:C0000076 ! cellular bud neck septin structure is_a: CCO:C0000490 ! septin ring is_a: CCO:C0001410 ! cleavage apparatus septin structure [Term] id: CCO:C0000024 name: exocyst namespace: cellular_component def: "Protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152] xref: GO:0000145 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001867 ! cell cortex part [Term] id: CCO:C0000025 name: 1,3-beta-glucan synthase complex namespace: cellular_component def: "The complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain." [EC:2.4.1.34] xref: GO:0000148 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000026 name: ubiquitin ligase complex namespace: cellular_component def: "A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex." [PMID:9529603] subset: goslim_pir subset: gosubset_prok xref: GO:0000151 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: location_of CCO:B0002086 ! BARD1_HUMAN relationship: location_of CCO:B0010848 ! BRCA1_HUMAN-Phosphoserine1330 [Term] id: CCO:C0000027 name: nuclear ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah] xref: GO:0000152 is_a: CCO:C0000026 ! ubiquitin ligase complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000028 name: cytoplasmic ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah] xref: GO:0000153 is_a: CCO:C0000026 ! ubiquitin ligase complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000029 name: protein phosphatase type 2A complex namespace: cellular_component def: "A heterodimer with protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic and regulatory subunits." [GOC:mah, ISBN:0198547684] xref: GO:0000159 is_a: CCO:C0000541 ! protein serine/threonine phosphatase complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000030 name: protein phosphatase type 1 complex namespace: cellular_component def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd] xref: GO:0000164 is_a: CCO:C0000541 ! protein serine/threonine phosphatase complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000031 name: ribonuclease MRP complex namespace: cellular_component def: "A ribonucleoprotein complex that performs the first cleavage in rRNA transcript processing and is also involved in mitochondrial RNA processing." [PMID:10690410] synonym: "ribonuclease mitochondrial RNA processing complex" EXACT [] synonym: "RNase MRP complex" EXACT [] xref: GO:0000172 is_a: CCO:C0001019 ! ribonucleoprotein complex [Term] id: CCO:C0000032 name: nuclear exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] xref: GO:0000176 is_a: CCO:C0000034 ! exosome (RNase complex) is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000033 name: cytoplasmic exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791] xref: GO:0000177 is_a: CCO:C0000034 ! exosome (RNase complex) is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000034 name: exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases." [PMID:10465791] comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. subset: goslim_pir xref: GO:0000178 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000035 name: tRNA-intron endonuclease complex namespace: cellular_component def: "A complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] xref: GO:0000214 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000036 name: vacuolar proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT [] xref: GO:0000220 is_a: CCO:C0001549 ! proton-transporting V-type ATPase, V0 domain relationship: part_of CCO:C0000793 ! vacuolar proton-transporting V-type ATPase complex [Term] id: CCO:C0000037 name: vacuolar proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain generally consists of eight subunits. synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT [] xref: GO:0000221 is_a: CCO:C0001550 ! proton-transporting V-type ATPase, V1 domain relationship: part_of CCO:C0000793 ! vacuolar proton-transporting V-type ATPase complex [Term] id: CCO:C0000038 name: plasma membrane proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT [] xref: GO:0000222 is_a: CCO:C0001549 ! proton-transporting V-type ATPase, V0 domain is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane relationship: part_of CCO:C0001551 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: CCO:C0000039 name: plasma membrane proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT [] xref: GO:0000223 is_a: CCO:C0001550 ! proton-transporting V-type ATPase, V1 domain is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane relationship: part_of CCO:C0001551 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: CCO:C0000040 name: nuclear chromosome namespace: cellular_component def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah] subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] xref: GO:0000228 is_a: CCO:C0000296 ! chromosome is_a: CCO:C0001847 ! nuclear part relationship: location_of CCO:B0001403 ! RAD21_HUMAN relationship: location_of CCO:B0001450 ! SMC2_HUMAN [Term] id: CCO:C0000041 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "cytoplasmic interphase chromosome" NARROW [] xref: GO:0000229 is_a: CCO:C0000296 ! chromosome is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000042 name: astral microtubule namespace: cellular_component def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] xref: GO:0000235 is_a: CCO:C0000436 ! spindle microtubule is_a: CCO:C0000439 ! cytoplasmic microtubule relationship: part_of CCO:C0000387 ! aster [Term] id: CCO:C0000043 name: pericentriolar material namespace: cellular_component def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] xref: GO:0000242 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001869 ! microtubule organizing center part relationship: location_of CCO:B0002211 ! TBE_HUMAN relationship: part_of CCO:C0000383 ! centrosome [Term] id: CCO:C0000044 name: commitment complex namespace: cellular_component def: "The first portion of the spliceosome to assemble in mRNA splicing; in commitment complex formation the 5' and 3' splice sites are recognized by the U1 snRNP and the U2 snRNP auxiliary factor, respectively." [PMID:9159080] synonym: "E complex" EXACT [] xref: GO:0000243 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part relationship: part_of CCO:C0000283 ! spliceosome [Term] id: CCO:C0000045 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] synonym: "mitochondrial DNA" NARROW [] synonym: "mitochondrial genome" RELATED [] synonym: "mtDNA" NARROW [] xref: GO:0000262 is_a: CCO:C0000296 ! chromosome is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0001678 ! mitochondrial nucleoid [Term] id: CCO:C0000046 name: cell fraction namespace: cellular_component def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: goslim_pir subset: gosubset_prok xref: GO:0000267 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000047 name: mitochondrial proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] synonym: "hydrogen-transporting ATP synthase, stator stalk (sensu Eukaryota)" EXACT [] synonym: "proton-transporting ATP synthase, stator stalk (sensu Eukaryota)" EXACT [] xref: GO:0000274 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001926 ! proton-transporting ATP synthase, stator stalk relationship: part_of CCO:C0000049 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: CCO:C0000048 name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, catalytic core F(1) (sensu Eukaryota)" EXACT [] xref: GO:0000275 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001922 ! proton-transporting ATP synthase complex, catalytic core F(1) relationship: part_of CCO:C0000337 ! mitochondrial proton-transporting ATP synthase complex [Term] id: CCO:C0000049 name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] synonym: "hydrogen-transporting ATP synthase, F0 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, coupling factor F(0) (sensu Eukaryota)" EXACT [] synonym: "proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukaryota)" EXACT [] xref: GO:0000276 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001924 ! proton-transporting ATP synthase complex, coupling factor F(o) relationship: part_of CCO:C0000337 ! mitochondrial proton-transporting ATP synthase complex [Term] id: CCO:C0000050 name: integral to membrane of membrane fraction namespace: cellular_component def: "Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. xref: GO:0000299 is_a: CCO:C0000244 ! membrane fraction [Term] id: CCO:C0000051 name: peripheral to membrane of membrane fraction namespace: cellular_component def: "Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. xref: GO:0000300 is_a: CCO:C0000244 ! membrane fraction [Term] id: CCO:C0000052 name: extrinsic to vacuolar membrane namespace: cellular_component def: "Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/] xref: GO:0000306 is_a: CCO:C0001199 ! extrinsic to organelle membrane is_a: CCO:C0001856 ! vacuolar part relationship: part_of CCO:C0000356 ! vacuolar membrane [Term] id: CCO:C0000053 name: cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] subset: goslim_pir synonym: "CDK holoenzyme" EXACT [] xref: GO:0000307 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: location_of CCO:B0011105 ! CDK2_HUMAN-Phosphotyrosine19 [Term] id: CCO:C0000054 name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] xref: GO:0000308 is_a: CCO:C0000053 ! cyclin-dependent protein kinase holoenzyme complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000055 name: plastid large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] xref: GO:0000311 is_a: CCO:C0000059 ! organellar large ribosomal subunit is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000674 ! plastid ribosome [Term] id: CCO:C0000056 name: plastid small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc] xref: GO:0000312 is_a: CCO:C0000058 ! organellar small ribosomal subunit is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000674 ! plastid ribosome [Term] id: CCO:C0000057 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular organelle." [GOC:mcc] xref: GO:0000313 is_a: CCO:C0000407 ! ribosome [Term] id: CCO:C0000058 name: organellar small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc] xref: GO:0000314 is_a: CCO:C0000756 ! small ribosomal subunit relationship: part_of CCO:C0000057 ! organellar ribosome [Term] id: CCO:C0000059 name: organellar large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] xref: GO:0000315 is_a: CCO:C0000755 ! large ribosomal subunit relationship: part_of CCO:C0000057 ! organellar ribosome [Term] id: CCO:C0000060 name: storage vacuole namespace: cellular_component def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc] xref: GO:0000322 is_a: CCO:C0000355 ! vacuole [Term] id: CCO:C0000061 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] xref: GO:0000323 is_a: CCO:C0000355 ! vacuole [Term] id: CCO:C0000064 name: protein storage vacuole namespace: cellular_component def: "A compound organelle of plants where there is a lytic vacuole within a storage vacuole." [PMID:11739409] xref: GO:0000326 is_a: CCO:C0000060 ! storage vacuole is_a: CCO:C0002152 ! plant-type vacuole [Term] id: CCO:C0000065 name: lytic vacuole within protein storage vacuole namespace: cellular_component def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490] xref: GO:0000327 is_a: CCO:C0000061 ! lytic vacuole is_a: CCO:C0000064 ! protein storage vacuole [Term] id: CCO:C0000069 name: contractile vacuole namespace: cellular_component def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:10503189] xref: GO:0000331 is_a: CCO:C0000355 ! vacuole [Term] id: CCO:C0000070 name: telomerase catalytic core complex namespace: cellular_component def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [PMID:11884619] xref: GO:0000333 is_a: CCO:C0000297 ! telomerase holoenzyme complex [Term] id: CCO:C0000071 name: plastid-encoded plastid RNA polymerase complex A namespace: cellular_component def: "The plastid-encoded plastid RNA polymerase A (PEP-A) is a plastid-encoded DNA-directed RNA polymerase that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105] synonym: "PEP-A" EXACT [] xref: GO:0000343 is_a: CCO:C0000084 ! plastid-encoded plastid RNA polymerase complex [Term] id: CCO:C0000072 name: plastid-encoded plastid RNA polymerase complex B namespace: cellular_component def: "The plastid-encoded plastid RNA polymerase B (PEP-B) is a plastid-encoded DNA-directed RNA polymerase that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105] synonym: "PEP-B" EXACT [] xref: GO:0000344 is_a: CCO:C0000084 ! plastid-encoded plastid RNA polymerase complex [Term] id: CCO:C0000073 name: cytosolic DNA-directed RNA polymerase complex namespace: cellular_component def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566] subset: gosubset_prok synonym: "cytosolic DNA-directed RNA polymerase complex (sensu Bacteria)" EXACT [] xref: GO:0000345 is_a: CCO:C0000085 ! DNA-directed RNA polymerase complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000074 name: transcription export complex namespace: cellular_component def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277] subset: goslim_pir synonym: "TREX complex" EXACT [] xref: GO:0000346 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000075 name: THO complex namespace: cellular_component def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] subset: goslim_pir xref: GO:0000347 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000076 name: cellular bud neck septin structure namespace: cellular_component def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc] xref: GO:0000399 is_a: CCO:C0001404 ! cell division site part relationship: part_of CCO:C0000487 ! cellular bud neck [Term] id: CCO:C0000077 name: pre-autophagosomal structure namespace: cellular_component def: "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] synonym: "PAS" EXACT [] xref: GO:0000407 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000078 name: EKC/KEOPS protein complex namespace: cellular_component def: "A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, PMID:16564010, PMID:16874308] synonym: "Endopeptidase-like Kinase Chromatin-associated protein complex" EXACT [] synonym: "Kinase, putative Endopeptidase and Other Proteins of Small size protein complex" EXACT [] xref: GO:0000408 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000079 name: HIR complex namespace: cellular_component def: "A protein complex proposed to be involved in replication-indepdent chromatin assembly. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, PMID:16303565] xref: GO:0000417 is_a: CCO:C0000281 ! chromatin assembly complex [Term] id: CCO:C0000080 name: DNA-directed RNA polymerase IV complex namespace: cellular_component def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The IVa and IVb complexes contain different forms of the largest subunit. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984] xref: GO:0000418 is_a: CCO:C0001870 ! nucleoplasm part is_a: CCO:C0002015 ! nuclear DNA-directed RNA polymerase complex [Term] id: CCO:C0000081 name: DNA-directed RNA polymerase IVb complex namespace: cellular_component def: "RNA polymerase IVb is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensu thes sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984] xref: GO:0000419 is_a: CCO:C0000080 ! DNA-directed RNA polymerase IV complex [Term] id: CCO:C0000082 name: DNA-directed RNA polymerase IVa complex namespace: cellular_component def: "RNA polymerase IVa is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVb, while the largest subunit is found only in the IVa complex. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984] xref: GO:0000420 is_a: CCO:C0000080 ! DNA-directed RNA polymerase IV complex [Term] id: CCO:C0000083 name: autophagic vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding an autophagic vacuole, a double-membrane bound vesicle in which endogenous cellular material is sequestered." [GOC:isa_complete] synonym: "autophagosome membrane" EXACT [] xref: GO:0000421 is_a: CCO:C0000356 ! vacuolar membrane relationship: part_of CCO:C0000358 ! autophagic vacuole [Term] id: CCO:C0000084 name: plastid-encoded plastid RNA polymerase complex namespace: cellular_component def: "Plastid-encoded plastid RNA polymerases are plastid-encoded DNA-directed RNA polymerases that resemble eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:pj] xref: GO:0000427 is_a: CCO:C0000085 ! DNA-directed RNA polymerase complex is_a: CCO:C0001854 ! plastid part [Term] id: CCO:C0000085 name: DNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] xref: GO:0000428 is_a: CCO:C0001068 ! RNA polymerase complex [Term] id: CCO:C0000086 name: core TFIIH complex portion of holo TFIIH complex namespace: cellular_component def: "The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] xref: GO:0000438 is_a: CCO:C0000087 ! core TFIIH complex relationship: part_of CCO:C0000091 ! SSL2-core TFIIH complex portion of holo TFIIH complex [Term] id: CCO:C0000087 name: core TFIIH complex namespace: cellular_component def: "A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of XPD, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB." [GOC:krc, PMID:14500720, PMID:7813015] xref: GO:0000439 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000089 ! SSL2-core TFIIH complex [Term] id: CCO:C0000088 name: core TFIIH complex portion of NEF3 complex namespace: cellular_component def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] xref: GO:0000440 is_a: CCO:C0000087 ! core TFIIH complex relationship: part_of CCO:C0000090 ! SSL2-core TFIIH complex portion of NEF3 complex [Term] id: CCO:C0000089 name: SSL2-core TFIIH complex namespace: cellular_component def: "A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of XPD, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] subset: goslim_pir xref: GO:0000441 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000090 name: SSL2-core TFIIH complex portion of NEF3 complex namespace: cellular_component def: "The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of XPD, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] xref: GO:0000442 is_a: CCO:C0000089 ! SSL2-core TFIIH complex relationship: part_of CCO:C0000006 ! nucleotide-excision repair factor 3 complex [Term] id: CCO:C0000091 name: SSL2-core TFIIH complex portion of holo TFIIH complex namespace: cellular_component def: "The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of XPD, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] xref: GO:0000443 is_a: CCO:C0000089 ! SSL2-core TFIIH complex relationship: part_of CCO:C0000279 ! holo TFIIH complex [Term] id: CCO:C0000092 name: MIS12/MIND type complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270] synonym: "Mis12 complex" NARROW [] xref: GO:0000444 is_a: CCO:C0001750 ! protein complex relationship: location_of CCO:B0002122 ! MIS12_HUMAN relationship: part_of CCO:C0000104 ! condensed chromosome kinetochore [Term] id: CCO:C0000093 name: THO complex part of transcription export complex namespace: cellular_component def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GO:krc, PMID:11060033, PMID:11979277, PMID:16983072] synonym: "THO complex part of TREX complex" EXACT [] xref: GO:0000445 is_a: CCO:C0000075 ! THO complex relationship: part_of CCO:C0000074 ! transcription export complex [Term] id: CCO:C0000094 name: nucleoplasmic THO complex namespace: cellular_component def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GO:krc, PMID:11060033, PMID:11979277, PMID:16983072] xref: GO:0000446 is_a: CCO:C0000075 ! THO complex is_a: CCO:C0000523 ! transcription elongation factor complex [Term] id: CCO:C0000095 name: RNA polymerase I upstream activating factor complex namespace: cellular_component def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378] synonym: "UAF" BROAD [] xref: GO:0000500 is_a: CCO:C0000010 ! RNA polymerase I transcription factor complex [Term] id: CCO:C0000099 name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411] comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity. synonym: "GPI-GlcNAc transferase complex" EXACT [] synonym: "GPI-GnT complex" EXACT [] synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT [] xref: GO:0000506 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001851 ! endoplasmic reticulum part [Term] id: CCO:C0000100 name: Rpd3L complex namespace: cellular_component def: "A multisubunit histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p." [GOC:rb, PMID:16286008, PMID:16314178] synonym: "Rpd3C(L)" EXACT [] xref: GO:0000508 is_a: CCO:C0000008 ! histone deacetylase complex [Term] id: CCO:C0000101 name: Rpd3S complex namespace: cellular_component def: "A multisubunit histone deacetylase complex that is involved in intragenic transcription repression through histone deacetylation. In S. cerevisiae, this complex consists of Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3." [GOC:rb, PMID:16286007, PMID:16286008] synonym: "Rpd3C(S)" EXACT [] xref: GO:0000509 is_a: CCO:C0000008 ! histone deacetylase complex [Term] id: CCO:C0000102 name: chromosome, pericentric region namespace: cellular_component def: "The central region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kva] comment: Note that this term can be used in place of the obsoleted cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "centromere" RELATED [] xref: GO:0000775 is_a: CCO:C0001846 ! chromosomal part relationship: location_of CCO:B0001391 ! SUV91_HUMAN relationship: location_of CCO:B0001973 ! SPC24_HUMAN relationship: location_of CCO:B0002122 ! MIS12_HUMAN relationship: location_of CCO:B0002143 ! SPC25_HUMAN relationship: location_of CCO:B0010824 ! BOREA_HUMAN-Phosphoserine165 relationship: location_of CCO:B0011147 ! CENPE_HUMAN-Phosphoserine454 relationship: location_of CCO:B0013810 ! RCC2_HUMAN-Phosphothreonine20 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: location_of CCO:B0031347 ! NDC80_HUMAN-Phosphoserine165 relationship: location_of CCO:B0041237 ! B1AQT3_HUMAN relationship: location_of CCO:B0041238 ! B1AQT4_HUMAN [Term] id: CCO:C0000103 name: kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the pericentric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] subset: goslim_pir xref: GO:0000776 xref: GO:0005699 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: location_of CCO:B0001748 ! MD2L1_HUMAN relationship: location_of CCO:B0010567 ! APC_HUMAN-Phosphoserine1038 relationship: location_of CCO:B0011263 ! CLIP1_HUMAN-Phosphoserine200 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: part_of CCO:C0000102 ! chromosome, pericentric region [Term] id: CCO:C0000104 name: condensed chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the pericentric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] xref: GO:0000777 is_a: CCO:C0000103 ! kinetochore relationship: part_of CCO:C0000106 ! condensed chromosome, pericentric region [Term] id: CCO:C0000105 name: condensed nuclear chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the pericentric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules." [GOC:elh] xref: GO:0000778 is_a: CCO:C0000104 ! condensed chromosome kinetochore is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000107 ! condensed nuclear chromosome, pericentric region [Term] id: CCO:C0000106 name: condensed chromosome, pericentric region namespace: cellular_component def: "The central region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kva] comment: Note that this term can be used in place of the obsoleted cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed chromosome, centromere" RELATED [] xref: GO:0000779 is_a: CCO:C0000102 ! chromosome, pericentric region relationship: part_of CCO:C0000120 ! condensed chromosome [Term] id: CCO:C0000107 name: condensed nuclear chromosome, pericentric region namespace: cellular_component def: "The central region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kva] comment: Note that this term can be used in place of the obsoleted cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed nuclear chromosome, centromere" RELATED [] xref: GO:0000780 is_a: CCO:C0000106 ! condensed chromosome, pericentric region is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000121 ! condensed nuclear chromosome [Term] id: CCO:C0000108 name: chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "telomere" RELATED [] xref: GO:0000781 is_a: CCO:C0001846 ! chromosomal part relationship: location_of CCO:B0010800 ! BLM_HUMAN-Phosphoserine419 relationship: location_of CCO:B0014336 ! TERF2_HUMAN-Phosphoserine380 [Term] id: CCO:C0000109 name: telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. subset: goslim_pir xref: GO:0000782 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000108 ! chromosome, telomeric region [Term] id: CCO:C0000110 name: nuclear telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. xref: GO:0000783 is_a: CCO:C0000109 ! telomere cap complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000111 ! nuclear chromosome, telomeric region [Term] id: CCO:C0000111 name: nuclear chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "nuclear chromosome, telomere" EXACT [] xref: GO:0000784 is_a: CCO:C0000108 ! chromosome, telomeric region is_a: CCO:C0001873 ! nuclear chromosome part [Term] id: CCO:C0000112 name: chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms the chromosome." [GOC:elh] synonym: "chromosome scaffold" RELATED [] xref: GO:0000785 xref: GO:0005717 is_a: CCO:C0001846 ! chromosomal part relationship: location_of CCO:B0001391 ! SUV91_HUMAN relationship: location_of CCO:B0001503 ! DPOLA_HUMAN relationship: location_of CCO:B0035935 ! MEN1_HUMAN relationship: location_of CCO:B0041306 ! HMGA2_HUMAN-Phosphoserine105 [Term] id: CCO:C0000113 name: nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] subset: goslim_pir xref: GO:0000786 xref: GO:0005718 is_a: CCO:C0001494 ! protein-DNA complex is_a: CCO:C0001846 ! chromosomal part relationship: location_of CCO:B0001481 ! HSP1_HUMAN relationship: location_of CCO:B0001482 ! PRM2_HUMAN relationship: location_of CCO:B0002149 ! PRM3_HUMAN relationship: location_of CCO:B0012010 ! H2AX_HUMAN-Phosphoserine140 relationship: part_of CCO:C0000112 ! chromatin [Term] id: CCO:C0000114 name: cytoplasmic nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh] xref: GO:0000787 is_a: CCO:C0000113 ! nucleosome is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000116 ! cytoplasmic chromatin [Term] id: CCO:C0000115 name: nuclear nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh] xref: GO:0000788 is_a: CCO:C0000113 ! nucleosome is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000117 ! nuclear chromatin [Term] id: CCO:C0000116 name: cytoplasmic chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms the chromosome in the cytoplasm." [GOC:elh] xref: GO:0000789 is_a: CCO:C0000112 ! chromatin is_a: CCO:C0001863 ! cytoplasmic part relationship: location_of CCO:B0001936 ! NPM2_HUMAN relationship: part_of CCO:C0000041 ! cytoplasmic chromosome [Term] id: CCO:C0000117 name: nuclear chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms the chromosome in the nucleus." [GOC:elh] xref: GO:0000790 is_a: CCO:C0000112 ! chromatin is_a: CCO:C0001873 ! nuclear chromosome part relationship: location_of CCO:B0001400 ! O43832_HUMAN relationship: location_of CCO:B0001936 ! NPM2_HUMAN relationship: location_of CCO:B0013808 ! RCC1_HUMAN-Phosphoserine406 relationship: location_of CCO:B0026255 ! KLDC3_HUMAN [Term] id: CCO:C0000118 name: euchromatin namespace: cellular_component def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh] xref: GO:0000791 is_a: CCO:C0000112 ! chromatin [Term] id: CCO:C0000119 name: heterochromatin namespace: cellular_component def: "A compact and highly condensed form of chromatin." [GOC:elh] xref: GO:0000792 is_a: CCO:C0000112 ! chromatin [Term] id: CCO:C0000120 name: condensed chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. synonym: "cytoplasmic mitotic chromosome" RELATED [] synonym: "metaphase chromosome" RELATED [] synonym: "mitotic chromosome" RELATED [] xref: GO:0000793 is_a: CCO:C0000296 ! chromosome relationship: location_of CCO:B0001400 ! O43832_HUMAN relationship: location_of CCO:B0001450 ! SMC2_HUMAN relationship: location_of CCO:B0001923 ! Q6ZNA8_HUMAN [Term] id: CCO:C0000121 name: condensed nuclear chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus." [GOC:elh] comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. synonym: "meiotic chromosome" RELATED [] synonym: "nuclear mitotic chromosome" RELATED [] xref: GO:0000794 is_a: CCO:C0000040 ! nuclear chromosome is_a: CCO:C0000120 ! condensed chromosome relationship: location_of CCO:B0001391 ! SUV91_HUMAN relationship: location_of CCO:B0001784 ! DMC1_HUMAN relationship: location_of CCO:B0001923 ! Q6ZNA8_HUMAN relationship: location_of CCO:B0002148 ! CHM1A_HUMAN relationship: location_of CCO:B0011213 ! CHK1_HUMAN-Phosphoserine296 relationship: location_of CCO:B0013808 ! RCC1_HUMAN-Phosphoserine406 [Term] id: CCO:C0000122 name: synaptonemal complex namespace: cellular_component def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh] xref: GO:0000795 xref: GO:0005716 is_a: CCO:C0001873 ! nuclear chromosome part relationship: location_of CCO:B0001900 ! Q5VXJ5_HUMAN relationship: part_of CCO:C0000121 ! condensed nuclear chromosome [Term] id: CCO:C0000123 name: condensin complex namespace: cellular_component def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] subset: goslim_pir synonym: "SMC complex" RELATED [] xref: GO:0000796 xref: GO:0005676 xref: GO:0008620 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: location_of CCO:B0001450 ! SMC2_HUMAN relationship: location_of CCO:B0014084 ! SMC4_HUMAN-Phosphoserine41 relationship: part_of CCO:C0000120 ! condensed chromosome [Term] id: CCO:C0000124 name: condensin core heterodimer namespace: cellular_component def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] synonym: "Smc2-Smc4 complex" NARROW [] xref: GO:0000797 xref: GO:0008621 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000123 ! condensin complex [Term] id: CCO:C0000125 name: nuclear cohesin complex namespace: cellular_component def: "A protein complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh] xref: GO:0000798 is_a: CCO:C0000538 ! cohesin complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000121 ! condensed nuclear chromosome [Term] id: CCO:C0000126 name: nuclear condensin complex namespace: cellular_component def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh] xref: GO:0000799 is_a: CCO:C0000123 ! condensin complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000121 ! condensed nuclear chromosome [Term] id: CCO:C0000127 name: lateral element namespace: cellular_component def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] synonym: "axial element" RELATED [] xref: GO:0000800 is_a: CCO:C0001873 ! nuclear chromosome part relationship: location_of CCO:B0010800 ! BLM_HUMAN-Phosphoserine419 relationship: part_of CCO:C0000122 ! synaptonemal complex [Term] id: CCO:C0000128 name: central element namespace: cellular_component def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh] xref: GO:0000801 is_a: CCO:C0001873 ! nuclear chromosome part relationship: location_of CCO:B0001915 ! SYCE2_HUMAN relationship: part_of CCO:C0000122 ! synaptonemal complex [Term] id: CCO:C0000129 name: transverse filament namespace: cellular_component def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh] xref: GO:0000802 is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000122 ! synaptonemal complex [Term] id: CCO:C0000130 name: sex chromosome namespace: cellular_component def: "A chromosome involved in sex determination." [GOC:elh] xref: GO:0000803 is_a: CCO:C0000296 ! chromosome [Term] id: CCO:C0000131 name: W chromosome namespace: cellular_component def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, ISBN:0321000382] xref: GO:0000804 is_a: CCO:C0000130 ! sex chromosome [Term] id: CCO:C0000132 name: X chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089] xref: GO:0000805 is_a: CCO:C0000130 ! sex chromosome [Term] id: CCO:C0000133 name: Y chromosome namespace: cellular_component def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089] xref: GO:0000806 is_a: CCO:C0000130 ! sex chromosome [Term] id: CCO:C0000134 name: Z chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, ISBN:0321000382] xref: GO:0000807 is_a: CCO:C0000130 ! sex chromosome [Term] id: CCO:C0000135 name: origin recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] subset: goslim_pir subset: gosubset_prok synonym: "ORC" EXACT [] synonym: "origin of replication recognition complex" EXACT [] xref: GO:0000808 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0000136 name: cytoplasmic origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh] subset: gosubset_prok synonym: "cytoplasmic ORC" EXACT [] synonym: "prokaryotic ORC" RELATED [] xref: GO:0000809 is_a: CCO:C0000135 ! origin recognition complex is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000041 ! cytoplasmic chromosome [Term] id: CCO:C0000137 name: GINS complex namespace: cellular_component def: "A multisubunit complex that associates with replication origins and is required for the initiation of DNA replication." [GOC:rn, PMID:12730134] synonym: "Go, Ichi, Ni and San complex" EXACT [] xref: GO:0000811 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001873 ! nuclear chromosome part [Term] id: CCO:C0000138 name: SWR1 complex namespace: cellular_component def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [PMID:14645854, PMID:14690608] synonym: "SWR-C" EXACT [] xref: GO:0000812 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0000139 name: ESCRT I complex namespace: cellular_component def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] xref: GO:0000813 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001859 ! endosomal part relationship: part_of CCO:C0000713 ! endosome membrane [Term] id: CCO:C0000140 name: ESCRT II complex namespace: cellular_component def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] xref: GO:0000814 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001859 ! endosomal part relationship: part_of CCO:C0000713 ! endosome membrane [Term] id: CCO:C0000141 name: ESCRT III complex namespace: cellular_component def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] xref: GO:0000815 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001859 ! endosomal part relationship: part_of CCO:C0000713 ! endosome membrane [Term] id: CCO:C0000142 name: COMA complex namespace: cellular_component def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm1p, Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972] synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT [] xref: GO:0000817 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000105 ! condensed nuclear chromosome kinetochore [Term] id: CCO:C0000143 name: nuclear MIS12/MIND type complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972] synonym: "MIND complex" EXACT [] synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT [] xref: GO:0000818 is_a: CCO:C0000092 ! MIS12/MIND type complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000105 ! condensed nuclear chromosome kinetochore [Term] id: CCO:C0000144 name: spindle pole namespace: cellular_component def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] xref: GO:0000922 xref: GO:0030615 is_a: CCO:C0001849 ! cytoskeletal part relationship: location_of CCO:B0001659 ! KIF11_HUMAN relationship: location_of CCO:B0011452 ! DCTN1_HUMAN-Phosphoserine541 relationship: location_of CCO:B0012613 ! KNTC1_HUMAN-Phosphoserine2098 relationship: location_of CCO:B0012680 ! LATS1_HUMAN-Phosphoserine909 relationship: location_of CCO:B0013325 ! NUMA1_HUMAN-Phosphoserine2077 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: part_of CCO:C0000388 ! spindle [Term] id: CCO:C0000145 name: equatorial microtubule organizing center namespace: cellular_component def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817] synonym: "EMTOC" EXACT [] synonym: "equatorial microtubule organising centre" EXACT [] xref: GO:0000923 is_a: CCO:C0000385 ! microtubule organizing center is_a: CCO:C0001404 ! cell division site part [Term] id: CCO:C0000146 name: gamma-tubulin ring complex, centrosomal namespace: cellular_component def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256] synonym: "gamma-tubulin large complex (sensu Metazoa)" EXACT [] synonym: "gamma-tubulin large complex, centrosomal" EXACT [] synonym: "gamma-tubulin ring complex, centrosomal (sensu Metazoa)" EXACT [] xref: GO:0000924 xref: GO:0000925 xref: GO:0000926 is_a: CCO:C0000536 ! gamma-tubulin ring complex relationship: part_of CCO:C0000043 ! pericentriolar material [Term] id: CCO:C0000147 name: gamma-tubulin small complex, centrosomal namespace: cellular_component def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [GOC:mtg_sensu, PMID:12134075] synonym: "gamma-tubulin small complex (sensu Metazoa)" EXACT [] xref: GO:0000927 is_a: CCO:C0000537 ! gamma-tubulin small complex is_a: CCO:C0001849 ! cytoskeletal part [Term] id: CCO:C0000148 name: gamma-tubulin small complex, spindle pole body namespace: cellular_component def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms." [GOC:mtg_sensu, PMID:12134075] synonym: "gamma-tubulin complex (sensu Saccharomyces)" BROAD [] synonym: "Tub4 complex" EXACT [] xref: GO:0000928 is_a: CCO:C0000537 ! gamma-tubulin small complex is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000386 ! spindle pole body [Term] id: CCO:C0000149 name: gamma-tubulin complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075] subset: goslim_pir xref: GO:0000930 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001869 ! microtubule organizing center part relationship: location_of CCO:B0011243 ! CKAP5_HUMAN-Phosphoserine816 [Term] id: CCO:C0000150 name: gamma-tubulin large complex namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes." [GOC:mtg_sensu, PMID:12134075] synonym: "gamma-tubulin large complex (sensu Schizosaccharomyces)" EXACT [] xref: GO:0000929 xref: GO:0000931 is_a: CCO:C0000149 ! gamma-tubulin complex is_a: CCO:C0001849 ! cytoskeletal part [Term] id: CCO:C0000151 name: cytoplasmic mRNA processing body namespace: cellular_component def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] synonym: "cytoplasmic foci" RELATED [] synonym: "P body" EXACT [] synonym: "P-body" EXACT [] xref: GO:0000932 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000152 name: adventitious septum namespace: cellular_component def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526] xref: GO:0000933 is_a: CCO:C0001008 ! cell septum [Term] id: CCO:C0000153 name: porous cell septum namespace: cellular_component def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt] synonym: "porous septum" BROAD [] xref: GO:0000934 is_a: CCO:C0001008 ! cell septum [Term] id: CCO:C0000154 name: barrier septum namespace: cellular_component def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt] synonym: "complete septum" EXACT [] xref: GO:0000935 is_a: CCO:C0001008 ! cell septum [Term] id: CCO:C0000155 name: primary cell septum namespace: cellular_component def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526] synonym: "primary septum" BROAD [] xref: GO:0000936 is_a: CCO:C0001008 ! cell septum [Term] id: CCO:C0000156 name: dolipore septum namespace: cellular_component def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt] xref: GO:0000937 is_a: CCO:C0000153 ! porous cell septum [Term] id: CCO:C0000157 name: GARP complex namespace: cellular_component def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] synonym: "Golgi associated retrograde protein complex" EXACT [] synonym: "VFT tethering complex" EXACT [] synonym: "Vps fifty three tethering complex" EXACT [] xref: GO:0000938 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001850 ! Golgi apparatus part is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0000158 name: inner kinetochore of condensed chromosome namespace: cellular_component def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983] synonym: "inner centromere core complex" RELATED [] synonym: "inner kinetochore plate" NARROW [] xref: GO:0000939 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000104 ! condensed chromosome kinetochore [Term] id: CCO:C0000159 name: outer kinetochore of condensed chromosome namespace: cellular_component def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983] synonym: "outer kinetochore plate" NARROW [] xref: GO:0000940 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: location_of CCO:B0011147 ! CENPE_HUMAN-Phosphoserine454 relationship: part_of CCO:C0000104 ! condensed chromosome kinetochore [Term] id: CCO:C0000160 name: inner kinetochore of condensed nuclear chromosome namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398] xref: GO:0000941 is_a: CCO:C0000158 ! inner kinetochore of condensed chromosome is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000105 ! condensed nuclear chromosome kinetochore [Term] id: CCO:C0000161 name: outer kinetochore of condensed nuclear chromosome namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398] xref: GO:0000942 is_a: CCO:C0000159 ! outer kinetochore of condensed chromosome is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000105 ! condensed nuclear chromosome kinetochore [Term] id: CCO:C0000162 name: retrotransposon nucleocapsid namespace: cellular_component def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903] synonym: "Virus-like particle" EXACT [] synonym: "VLP" EXACT [] xref: GO:0000943 is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000163 name: mating projection base namespace: cellular_component def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc] synonym: "base of shmoo tip" NARROW [] synonym: "conjugation tube base" NARROW [] xref: GO:0001400 is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0000488 ! mating projection [Term] id: CCO:C0000164 name: mitochondrial sorting and assembly machinery complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361] comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'. synonym: "SAM complex" EXACT [] synonym: "TOB complex" EXACT [] xref: GO:0001401 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000327 ! mitochondrial outer membrane [Term] id: CCO:C0000165 name: presequence translocase-associated import motor namespace: cellular_component def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix." [GOC:mcc, PMID:14517234, PMID:14638855] synonym: "mitochondrial import motor" EXACT [] synonym: "PAM complex" EXACT [] synonym: "pre-sequence translocase-associated import motor" EXACT [] xref: GO:0001405 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000330 ! mitochondrial inner membrane presequence translocase complex [Term] id: CCO:C0000166 name: hyphal tip namespace: cellular_component def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc] subset: goslim_candida xref: GO:0001411 is_a: CCO:C0001007 ! site of polarized growth [Term] id: CCO:C0000167 name: voltage-gated sodium channel complex namespace: cellular_component def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "voltage gated sodium channel complex" EXACT [] synonym: "voltage-dependent sodium channel complex" EXACT [] synonym: "voltage-sensitive sodium channel complex" EXACT [] xref: GO:0001518 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000168 name: outer dense fiber namespace: cellular_component def: "Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile." [ISBN:0824072820] synonym: "outer dense fibre" EXACT [] xref: GO:0001520 is_a: CCO:C0001866 ! axoneme part [Term] id: CCO:C0000169 name: microfibril namespace: cellular_component def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [http://www.xrefer.com/entry/490235] synonym: "extended fibrils" EXACT [] synonym: "fibrillin" RELATED [] xref: GO:0001527 is_a: CCO:C0001734 ! fibril [Term] id: CCO:C0000170 name: cornified envelope namespace: cellular_component def: "An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells." [PMID:11112355] xref: GO:0001533 is_a: CCO:C0000421 ! cytoskeleton [Term] id: CCO:C0000171 name: radial spoke namespace: cellular_component def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971] subset: goslim_pir xref: GO:0001534 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001866 ! axoneme part [Term] id: CCO:C0000172 name: radial spokehead namespace: cellular_component def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:hjd] xref: GO:0001535 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001866 ! axoneme part relationship: part_of CCO:C0000171 ! radial spoke [Term] id: CCO:C0000173 name: radial spoke stalk namespace: cellular_component def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd] xref: GO:0001536 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001866 ! axoneme part relationship: part_of CCO:C0000171 ! radial spoke [Term] id: CCO:C0000174 name: fibrillar center namespace: cellular_component def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561] synonym: "fibrillar centre" EXACT [] xref: GO:0001650 is_a: CCO:C0001871 ! nucleolar part [Term] id: CCO:C0000175 name: dense fibrillar component namespace: cellular_component def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] xref: GO:0001651 is_a: CCO:C0001871 ! nucleolar part [Term] id: CCO:C0000176 name: granular component namespace: cellular_component def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561] xref: GO:0001652 is_a: CCO:C0001871 ! nucleolar part [Term] id: CCO:C0000177 name: acrosome namespace: cellular_component def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0001669 is_a: CCO:C0000347 ! lysosome [Term] id: CCO:C0000178 name: male germ cell nucleus namespace: cellular_component def: "The nucleus of a male germ cell, a cell specialized to produce haploid gametes, and its descendents." [GOC:hjd, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk] synonym: "male germ cell nucleus (sensu Metazoa)" EXACT [] synonym: "male germ-cell nucleus" EXACT [] synonym: "male germ-cell nucleus (sensu Metazoa)" EXACT [] xref: GO:0001673 xref: GO:0043081 is_a: CCO:C0001713 ! germ cell nucleus [Term] id: CCO:C0000179 name: female germ cell nucleus namespace: cellular_component def: "The nucleus of the female germ cell, a cell specialized to produce haploid gametes, and its descendents." [GOC:hjd, http://cancerweb.ncl.ac.uk] synonym: "female germ cell nucleus (sensu Metazoa)" EXACT [] synonym: "female germ-cell nucleus" EXACT [] synonym: "female germ-cell nucleus (sensu Animalia)" EXACT [] xref: GO:0001674 xref: GO:0043080 is_a: CCO:C0001713 ! germ cell nucleus [Term] id: CCO:C0000180 name: stress fiber namespace: cellular_component def: "Bundle of microfilaments and other proteins found in fibroblasts." [ISBN:0124325653] synonym: "stress fibre" EXACT [] xref: GO:0001725 is_a: CCO:C0001449 ! actin filament bundle relationship: location_of CCO:B0014006 ! SEPT7_HUMAN-Phosphoserine423 relationship: location_of CCO:B0036017 ! MYH10_HUMAN-Phosphothreonine1376 [Term] id: CCO:C0000181 name: ruffle namespace: cellular_component def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] synonym: "membrane ruffle" RELATED [] xref: GO:0001726 is_a: CCO:C0001706 ! cell projection relationship: location_of CCO:B0001546 ! NDKB_HUMAN relationship: location_of CCO:B0002257 ! CD2AP_HUMAN relationship: part_of CCO:C0001172 ! leading edge [Term] id: CCO:C0000182 name: sex chromatin namespace: cellular_component def: "A condensed mass of compacted chromatin that represents an inactivated X chromosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0001739 is_a: CCO:C0000310 ! nuclear heterochromatin relationship: part_of CCO:C0000130 ! sex chromosome [Term] id: CCO:C0000183 name: Barr body namespace: cellular_component def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] xref: GO:0001740 is_a: CCO:C0000132 ! X chromosome is_a: CCO:C0000182 ! sex chromatin [Term] id: CCO:C0000184 name: XY body namespace: cellular_component def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] xref: GO:0001741 is_a: CCO:C0000182 ! sex chromatin [Term] id: CCO:C0000185 name: photoreceptor outer segment namespace: cellular_component def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [ISBN:0824072820] xref: GO:0001750 is_a: CCO:C0001281 ! nonmotile primary cilium [Term] id: CCO:C0000186 name: immunological synapse namespace: cellular_component def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300] synonym: "c-SMAC" NARROW [PMID:14724296] synonym: "supramolecular activation cluster" EXACT [PMID:14724296] xref: GO:0001772 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000187 name: phagocytic cup namespace: cellular_component def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769] xref: GO:0001891 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000188 name: photoreceptor inner segment namespace: cellular_component def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563] subset: goslim_pir xref: GO:0001917 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000189 name: uropod namespace: cellular_component def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12714569, PMID:12787750] synonym: "distal pole complex" RELATED [] synonym: "retractile pole" RELATED [] synonym: "uropodium" EXACT [] xref: GO:0001931 is_a: CCO:C0001706 ! cell projection relationship: part_of CCO:C0001174 ! trailing edge [Term] id: CCO:C0000190 name: female pronucleus namespace: cellular_component def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0001939 is_a: CCO:C0001889 ! pronucleus [Term] id: CCO:C0000191 name: male pronucleus namespace: cellular_component def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0001940 is_a: CCO:C0001889 ! pronucleus [Term] id: CCO:C0000192 name: PME fraction namespace: cellular_component def: "The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832] xref: GO:0001950 is_a: CCO:C0000046 ! cell fraction relationship: part_of CCO:C0000244 ! membrane fraction [Term] id: CCO:C0000193 name: inner acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405] xref: GO:0002079 is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0000194 ! acrosomal membrane [Term] id: CCO:C0000194 name: acrosomal membrane namespace: cellular_component def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph] xref: GO:0002080 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0000177 ! acrosome [Term] id: CCO:C0000195 name: outer acrosomal membrane namespace: cellular_component def: "The acrosomal region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405] xref: GO:0002081 is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0000194 ! acrosomal membrane [Term] id: CCO:C0000196 name: caveolar macromolecular signaling complex namespace: cellular_component def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270] synonym: "caveolar macromolecular signalling complex" EXACT [] xref: GO:0002095 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000458 ! caveola [Term] id: CCO:C0000197 name: polkadots namespace: cellular_component def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340] comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots. xref: GO:0002096 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000198 name: podosome namespace: cellular_component def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. xref: GO:0002102 is_a: CCO:C0001742 ! organelle is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0000199 name: BRCA2-BRAF35 complex namespace: cellular_component def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365] xref: GO:0002111 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000200 name: cellular_component namespace: cellular_component def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "cellular component unknown" NARROW [] xref: GO:0005575 xref: GO:0008372 is_a: CCO:U0000001 ! biological continuant relationship: location_of CCO:B0001519 ! CCNB1_HUMAN relationship: location_of CCO:B0001551 ! CCND1_HUMAN relationship: location_of CCO:B0001561 ! G0S2_HUMAN relationship: location_of CCO:B0001786 ! Q14569_HUMAN relationship: location_of CCO:B0001815 ! Q16164_HUMAN relationship: location_of CCO:B0002044 ! CK5P3_HUMAN relationship: location_of CCO:B0002068 ! Q99539_HUMAN relationship: location_of CCO:B0002069 ! Q99540_HUMAN relationship: location_of CCO:B0002121 ! Q9GZT1_HUMAN relationship: location_of CCO:B0002147 ! BRMS1_HUMAN relationship: location_of CCO:B0002149 ! PRM3_HUMAN relationship: location_of CCO:B0002174 ! BTG4_HUMAN relationship: location_of CCO:B0002246 ! OSGI2_HUMAN relationship: location_of CCO:B0011092 ! CDCA3_HUMAN-Phosphoserine68 relationship: location_of CCO:B0011546 ! DMWD_HUMAN-Phosphoserine530 relationship: location_of CCO:B0012941 ! MK03_HUMAN-N-acetylalanine2 [Term] id: CCO:C0000201 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not uniformly attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "extracellular" EXACT [] xref: GO:0005576 is_a: CCO:C0000200 ! cellular_component relationship: location_of CCO:B0001362 ! EREG_HUMAN relationship: location_of CCO:B0001470 ! EGF_HUMAN relationship: location_of CCO:B0001471 ! TGFB1_HUMAN relationship: location_of CCO:B0001485 ! INHA_HUMAN relationship: location_of CCO:B0001515 ! BMP2_HUMAN relationship: location_of CCO:B0001607 ! NBL1_HUMAN relationship: location_of CCO:B0001931 ! VASH1_HUMAN [Term] id: CCO:C0000202 name: fibrinogen complex namespace: cellular_component def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] synonym: "fibrinogen" EXACT [] synonym: "fibrinogen alpha chain" NARROW [] synonym: "fibrinogen beta chain" NARROW [] synonym: "fibrinogen gamma chain" NARROW [] xref: GO:0005577 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0000203 name: proteinaceous extracellular matrix namespace: cellular_component def: "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity." [GOC:mtg_sensu, ISBN:0198547684] subset: goslim_generic subset: goslim_goa subset: goslim_plant synonym: "extracellular matrix (sensu Metazoa)" EXACT [] xref: GO:0005578 is_a: CCO:C0001109 ! extracellular matrix is_a: CCO:C0001840 ! extracellular region part relationship: location_of CCO:B0001471 ! TGFB1_HUMAN [Term] id: CCO:C0000204 name: membrane attack complex namespace: cellular_component def: "A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"] synonym: "MAC" EXACT [] synonym: "membrane attack complex protein alphaM chain" NARROW [] synonym: "membrane attack complex protein beta2 chain" NARROW [] synonym: "TCC" EXACT [] synonym: "terminal complement complex" EXACT [] xref: GO:0005579 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001978 ! pore complex [Term] id: CCO:C0000205 name: collagen namespace: cellular_component def: "Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976] synonym: "other collagen" RELATED [] xref: GO:0005581 is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000203 ! proteinaceous extracellular matrix [Term] id: CCO:C0000206 name: collagen type XV namespace: cellular_component def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes." [PMID:11158616, PMID:11937714] xref: GO:0005582 is_a: CCO:C0000205 ! collagen [Term] id: CCO:C0000207 name: fibrillar collagen namespace: cellular_component def: "Any collagen polymer in which collagen triple helices associate to form fibrils." [GOC:mah, ISBN:0721639976] xref: GO:0005583 is_a: CCO:C0000205 ! collagen [Term] id: CCO:C0000208 name: collagen type I namespace: cellular_component def: "A collagen heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; type I collagen triple helices associate to form banded fibrils." [ISBN:0721639976] xref: GO:0005584 is_a: CCO:C0000207 ! fibrillar collagen [Term] id: CCO:C0000209 name: collagen type II namespace: cellular_component def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: GO:0005585 is_a: CCO:C0000207 ! fibrillar collagen [Term] id: CCO:C0000210 name: collagen type III namespace: cellular_component def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: GO:0005586 is_a: CCO:C0000207 ! fibrillar collagen [Term] id: CCO:C0000211 name: collagen type IV namespace: cellular_component def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes." [ISBN:0721639976] xref: GO:0005587 is_a: CCO:C0001088 ! sheet-forming collagen relationship: part_of CCO:C0000227 ! basement membrane [Term] id: CCO:C0000212 name: collagen type V namespace: cellular_component def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: GO:0005588 is_a: CCO:C0000207 ! fibrillar collagen [Term] id: CCO:C0000213 name: collagen type VI namespace: cellular_component def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976] xref: GO:0005589 is_a: CCO:C0001087 ! anchoring collagen [Term] id: CCO:C0000214 name: collagen type VII namespace: cellular_component def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue." [ISBN:0721639976] xref: GO:0005590 is_a: CCO:C0001087 ! anchoring collagen [Term] id: CCO:C0000215 name: collagen type VIII namespace: cellular_component def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976] xref: GO:0005591 is_a: CCO:C0000222 ! short-chain collagen [Term] id: CCO:C0000216 name: collagen type XI namespace: cellular_component def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: GO:0005592 is_a: CCO:C0000207 ! fibrillar collagen [Term] id: CCO:C0000217 name: FACIT collagen namespace: cellular_component def: "Any collagen polymer associated with collagen fibrils and in which the collagen monomers contain two or more relatively short triple-helical domains connected by non-triple-helical sequences; the acronym FACIT stands for fibril-associated collagen with interrupted triple helix." [ISBN:0198599587] xref: GO:0005593 is_a: CCO:C0001087 ! anchoring collagen [Term] id: CCO:C0000218 name: collagen type IX namespace: cellular_component def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976] xref: GO:0005594 is_a: CCO:C0000217 ! FACIT collagen [Term] id: CCO:C0000219 name: collagen type XII namespace: cellular_component def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] xref: GO:0005595 is_a: CCO:C0000217 ! FACIT collagen [Term] id: CCO:C0000220 name: collagen type XIV namespace: cellular_component def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] xref: GO:0005596 is_a: CCO:C0000217 ! FACIT collagen [Term] id: CCO:C0000221 name: collagen type XVI namespace: cellular_component def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140] xref: GO:0005597 is_a: CCO:C0000217 ! FACIT collagen [Term] id: CCO:C0000222 name: short-chain collagen namespace: cellular_component def: "Any assembly of collagen in which the collagen chains are relatively short compared to the fibrillar collagens." [ISBN:0198599587] xref: GO:0005598 is_a: CCO:C0001088 ! sheet-forming collagen [Term] id: CCO:C0000223 name: collagen type X namespace: cellular_component def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices may form nets." [ISBN:0721639976] xref: GO:0005599 is_a: CCO:C0000222 ! short-chain collagen [Term] id: CCO:C0000224 name: collagen type XIII namespace: cellular_component def: "A collagen homotrimer of alpha1(XIII) chains; type X collagen triple helices span lipid bilayer membranes." [ISBN:0721639976] xref: GO:0005600 is_a: CCO:C0001089 ! transmembrane collagen [Term] id: CCO:C0000225 name: classical-complement-pathway C3/C5 convertase complex namespace: cellular_component def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html] xref: GO:0005601 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0000226 name: complement component C1 complex namespace: cellular_component def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "complement component C1q complex" NARROW [] xref: GO:0005602 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0000227 name: basement membrane namespace: cellular_component def: "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684] xref: GO:0005604 is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000203 ! proteinaceous extracellular matrix [Term] id: CCO:C0000228 name: basal lamina namespace: cellular_component def: "A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684] synonym: "basement lamina" EXACT [] xref: GO:0005605 is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000227 ! basement membrane [Term] id: CCO:C0000229 name: laminin-1 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0005606 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0000230 name: laminin-2 complex namespace: cellular_component def: "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0005607 is_a: CCO:C0001756 ! laminin complex is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000762 ! dystroglycan complex [Term] id: CCO:C0000231 name: laminin-3 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761] xref: GO:0005608 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0000232 name: laminin-4 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0005609 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0000233 name: laminin-5 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0005610 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0000234 name: laminin-6 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0005611 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0000235 name: laminin-7 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0005612 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0000236 name: interstitial matrix namespace: cellular_component def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001] xref: GO:0005614 is_a: CCO:C0000203 ! proteinaceous extracellular matrix [Term] id: CCO:C0000237 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_generic subset: goslim_goa subset: goslim_plant synonym: "intercellular space" RELATED [] xref: GO:0005615 is_a: CCO:C0001840 ! extracellular region part relationship: location_of CCO:B0001362 ! EREG_HUMAN relationship: location_of CCO:B0001471 ! TGFB1_HUMAN relationship: location_of CCO:B0001515 ! BMP2_HUMAN [Term] id: CCO:C0000238 name: larval serum protein complex namespace: cellular_component def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, UniProtKB:P11995] xref: GO:0005616 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0000239 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0005618 is_a: CCO:C0000999 ! external encapsulating structure [Term] id: CCO:C0000241 name: cellular bud scar namespace: cellular_component def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820] xref: GO:0005621 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0002066 ! fungal-type cell wall [Term] id: CCO:C0000242 name: intracellular namespace: cellular_component def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "protoplasm" EXACT [] xref: GO:0005622 is_a: CCO:C0001882 ! cell part relationship: location_of CCO:B0001393 ! O43550_HUMAN relationship: location_of CCO:B0001408 ! EVI5_HUMAN relationship: location_of CCO:B0001416 ! TRI13_HUMAN relationship: location_of CCO:B0001458 ! BCL10_HUMAN relationship: location_of CCO:B0001520 ! ERF3A_HUMAN relationship: location_of CCO:B0001551 ! CCND1_HUMAN relationship: location_of CCO:B0001603 ! BCL6_HUMAN relationship: location_of CCO:B0001630 ! CTCF_HUMAN relationship: location_of CCO:B0001783 ! HIC1_HUMAN relationship: location_of CCO:B0001784 ! DMC1_HUMAN relationship: location_of CCO:B0001875 ! HECD3_HUMAN relationship: location_of CCO:B0001899 ! DAB2P_HUMAN relationship: location_of CCO:B0001923 ! Q6ZNA8_HUMAN relationship: location_of CCO:B0002086 ! BARD1_HUMAN relationship: location_of CCO:B0002127 ! Q9H2F0_HUMAN relationship: location_of CCO:B0002205 ! MUTYH_HUMAN relationship: location_of CCO:B0002206 ! HERC5_HUMAN relationship: location_of CCO:B0002228 ! ASC_HUMAN relationship: location_of CCO:B0010482 ! AKAP8_HUMAN-Phosphoserine112 relationship: location_of CCO:B0010800 ! BLM_HUMAN-Phosphoserine419 relationship: location_of CCO:B0010848 ! BRCA1_HUMAN-Phosphoserine1330 relationship: location_of CCO:B0011563 ! DNL3_HUMAN-Phosphothreonine122 relationship: location_of CCO:B0011612 ! E2AK2_HUMAN-Phosphothreonine88 relationship: location_of CCO:B0011980 ! GRLF1_HUMAN-Phosphoserine1179 relationship: location_of CCO:B0013709 ! RAP1A_HUMAN-Cysteine methyl ester181 relationship: location_of CCO:B0019420 ! Q53FN2_HUMAN relationship: location_of CCO:B0039948 ! ZFP42_HUMAN relationship: location_of CCO:B0039949 ! FSD1_HUMAN relationship: location_of CCO:B0041257 ! E4F1_HUMAN [Term] id: CCO:C0000243 name: cell namespace: cellular_component def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: gosubset_prok xref: GO:0005623 is_a: CCO:C0000200 ! cellular_component [Term] id: CCO:C0000244 name: membrane fraction namespace: cellular_component def: "That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: goslim_candida subset: goslim_yeast subset: gosubset_prok xref: GO:0005624 is_a: CCO:C0000046 ! cell fraction relationship: location_of CCO:B0001737 ! STRN3_HUMAN relationship: location_of CCO:B0002175 ! NSMA2_HUMAN relationship: location_of CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 [Term] id: CCO:C0000245 name: soluble fraction namespace: cellular_component def: "That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. synonym: "soluble" BROAD [] xref: GO:0005625 is_a: CCO:C0000046 ! cell fraction relationship: location_of CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:C0000246 name: insoluble fraction namespace: cellular_component def: "That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. synonym: "particle-bound" RELATED [] xref: GO:0005626 is_a: CCO:C0000046 ! cell fraction relationship: location_of CCO:B0001758 ! ULA1_HUMAN [Term] id: CCO:C0000247 name: prospore membrane namespace: cellular_component def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls." [ISBN:0879693649] subset: gosubset_prok synonym: "forespore membrane (sensu Fungi)" EXACT [] synonym: "FSM" EXACT [] xref: GO:0005628 is_a: CCO:C0000766 ! membrane relationship: part_of CCO:C0002135 ! ascospore-type prospore [Term] id: CCO:C0000248 name: dityrosine layer of spore wall namespace: cellular_component def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] xref: GO:0005630 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0002065 ! fungal-type spore wall [Term] id: CCO:C0000249 name: chitosan layer of spore wall namespace: cellular_component def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] xref: GO:0005631 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0002065 ! fungal-type spore wall [Term] id: CCO:C0000250 name: inner layer of spore wall namespace: cellular_component def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568] xref: GO:0005632 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0002065 ! fungal-type spore wall [Term] id: CCO:C0000251 name: ascus lipid droplet namespace: cellular_component def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293] xref: GO:0005633 is_a: CCO:C0000382 ! lipid particle [Term] id: CCO:C0000252 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: GO:0005634 is_a: CCO:C0002129 ! intracellular membrane-bounded organelle relationship: location_of CCO:B0001333 ! A6NK88_HUMAN relationship: location_of CCO:B0001341 ! A6NMP7_HUMAN relationship: location_of CCO:B0001343 ! A7KMP4_HUMAN relationship: location_of CCO:B0001345 ! SPT5H_HUMAN relationship: location_of CCO:B0001355 ! CDKA1_HUMAN relationship: location_of CCO:B0001365 ! TBX3_HUMAN relationship: location_of CCO:B0001370 ! FANCG_HUMAN relationship: location_of CCO:B0001372 ! PPM1D_HUMAN relationship: location_of CCO:B0001391 ! SUV91_HUMAN relationship: location_of CCO:B0001403 ! RAD21_HUMAN relationship: location_of CCO:B0001408 ! EVI5_HUMAN relationship: location_of CCO:B0001419 ! HUS1_HUMAN relationship: location_of CCO:B0001450 ! SMC2_HUMAN relationship: location_of CCO:B0001451 ! YETS4_HUMAN relationship: location_of CCO:B0001458 ! BCL10_HUMAN relationship: location_of CCO:B0001470 ! EGF_HUMAN relationship: location_of CCO:B0001481 ! HSP1_HUMAN relationship: location_of CCO:B0001482 ! PRM2_HUMAN relationship: location_of CCO:B0001503 ! DPOLA_HUMAN relationship: location_of CCO:B0001519 ! CCNB1_HUMAN relationship: location_of CCO:B0001524 ! NDKA_HUMAN relationship: location_of CCO:B0001538 ! CCNA2_HUMAN relationship: location_of CCO:B0001546 ! NDKB_HUMAN relationship: location_of CCO:B0001551 ! CCND1_HUMAN relationship: location_of CCO:B0001552 ! GA45A_HUMAN relationship: location_of CCO:B0001585 ! TF2H1_HUMAN relationship: location_of CCO:B0001594 ! DDIT3_HUMAN relationship: location_of CCO:B0001595 ! AHR_HUMAN relationship: location_of CCO:B0001596 ! PP1G_HUMAN relationship: location_of CCO:B0001601 ! MLH1_HUMAN relationship: location_of CCO:B0001603 ! BCL6_HUMAN relationship: location_of CCO:B0001628 ! UB2R1_HUMAN relationship: location_of CCO:B0001630 ! CTCF_HUMAN relationship: location_of CCO:B0001640 ! CDN1C_HUMAN relationship: location_of CCO:B0001644 ! CDK7_HUMAN relationship: location_of CCO:B0001655 ! NEK4_HUMAN relationship: location_of CCO:B0001662 ! PPP5_HUMAN relationship: location_of CCO:B0001668 ! PMS1_HUMAN relationship: location_of CCO:B0001673 ! AIF1_HUMAN relationship: location_of CCO:B0001681 ! SESN2_HUMAN relationship: location_of CCO:B0001684 ! MLF1_HUMAN relationship: location_of CCO:B0001701 ! CCNA1_HUMAN relationship: location_of CCO:B0001702 ! TXN4A_HUMAN relationship: location_of CCO:B0001737 ! STRN3_HUMAN relationship: location_of CCO:B0001748 ! MD2L1_HUMAN relationship: location_of CCO:B0001781 ! E2F2_HUMAN relationship: location_of CCO:B0001783 ! HIC1_HUMAN relationship: location_of CCO:B0001784 ! DMC1_HUMAN relationship: location_of CCO:B0001799 ! MD2BP_HUMAN relationship: location_of CCO:B0001802 ! CD5R1_HUMAN relationship: location_of CCO:B0001806 ! DHC24_HUMAN relationship: location_of CCO:B0001831 ! Q3LRW5_HUMAN relationship: location_of CCO:B0001841 ! ESCO2_HUMAN relationship: location_of CCO:B0001861 ! SPDYC_HUMAN relationship: location_of CCO:B0001872 ! Q5T317_HUMAN relationship: location_of CCO:B0001894 ! LIN9_HUMAN relationship: location_of CCO:B0001896 ! Q5TZP9_HUMAN relationship: location_of CCO:B0001915 ! SYCE2_HUMAN relationship: location_of CCO:B0001923 ! Q6ZNA8_HUMAN relationship: location_of CCO:B0001926 ! Q6ZV00_HUMAN relationship: location_of CCO:B0001935 ! Q7Z774_HUMAN relationship: location_of CCO:B0001936 ! NPM2_HUMAN relationship: location_of CCO:B0001957 ! SYCP3_HUMAN relationship: location_of CCO:B0001959 ! TAF1L_HUMAN relationship: location_of CCO:B0001966 ! CD2A2_HUMAN relationship: location_of CCO:B0001973 ! SPC24_HUMAN relationship: location_of CCO:B0001980 ! DP13B_HUMAN relationship: location_of CCO:B0001998 ! Q8TEY4_HUMAN relationship: location_of CCO:B0001999 ! HASP_HUMAN relationship: location_of CCO:B0002001 ! Q8WUE3_HUMAN relationship: location_of CCO:B0002007 ! CCNB3_HUMAN relationship: location_of CCO:B0002012 ! RSPH1_HUMAN relationship: location_of CCO:B0002016 ! RAD54_HUMAN relationship: location_of CCO:B0002017 ! DDX12_HUMAN relationship: location_of CCO:B0002019 ! PCAF_HUMAN relationship: location_of CCO:B0002041 ! SENP5_HUMAN relationship: location_of CCO:B0002048 ! Q96LE1_HUMAN relationship: location_of CCO:B0002049 ! HEXI2_HUMAN relationship: location_of CCO:B0002065 ! CDC5L_HUMAN relationship: location_of CCO:B0002071 ! MPH6_HUMAN relationship: location_of CCO:B0002086 ! BARD1_HUMAN relationship: location_of CCO:B0002091 ! CITE2_HUMAN relationship: location_of CCO:B0002114 ! Q9BYG9_HUMAN relationship: location_of CCO:B0002119 ! AL2S2_HUMAN relationship: location_of CCO:B0002122 ! MIS12_HUMAN relationship: location_of CCO:B0002132 ! Q9H315_HUMAN relationship: location_of CCO:B0002143 ! SPC25_HUMAN relationship: location_of CCO:B0002148 ! CHM1A_HUMAN relationship: location_of CCO:B0002149 ! PRM3_HUMAN relationship: location_of CCO:B0002150 ! PAR6A_HUMAN relationship: location_of CCO:B0002172 ! TXN4B_HUMAN relationship: location_of CCO:B0002177 ! APC11_HUMAN relationship: location_of CCO:B0002183 ! SEP10_HUMAN relationship: location_of CCO:B0002205 ! MUTYH_HUMAN relationship: location_of CCO:B0002217 ! ING1_HUMAN relationship: location_of CCO:B0002220 ! TLK1_HUMAN relationship: location_of CCO:B0002221 ! FBX5_HUMAN relationship: location_of CCO:B0002260 ! RA54B_HUMAN relationship: location_of CCO:B0010482 ! AKAP8_HUMAN-Phosphoserine112 relationship: location_of CCO:B0010567 ! APC_HUMAN-Phosphoserine1038 relationship: location_of CCO:B0010628 ! ASPP1_HUMAN-Phosphoserine332 relationship: location_of CCO:B0010653 ! ATM_HUMAN-Phosphothreonine72 relationship: location_of CCO:B0010771 ! BCCIP_HUMAN-Phosphoserine112 relationship: location_of CCO:B0010800 ! BLM_HUMAN-Phosphoserine419 relationship: location_of CCO:B0010824 ! BOREA_HUMAN-Phosphoserine165 relationship: location_of CCO:B0010848 ! BRCA1_HUMAN-Phosphoserine1330 relationship: location_of CCO:B0010859 ! BRCA2_HUMAN-Phosphoserine683 relationship: location_of CCO:B0010903 ! CAF1B_HUMAN-Phosphothreonine495 relationship: location_of CCO:B0010926 ! CASL_HUMAN-Phosphotyrosine166 relationship: location_of CCO:B0010997 ! CCNE2_HUMAN-Phosphothreonine392 relationship: location_of CCO:B0010998 ! CCNH_HUMAN-Phosphoserine5 relationship: location_of CCO:B0011066 ! CDC26_HUMAN-Phosphoserine78 relationship: location_of CCO:B0011074 ! CDC27_HUMAN-Phosphothreonine430 relationship: location_of CCO:B0011087 ! CDC6_HUMAN-Phosphothreonine166 relationship: location_of CCO:B0011098 ! CDCA5_HUMAN-Phosphothreonine48 relationship: location_of CCO:B0011105 ! CDK2_HUMAN-Phosphotyrosine19 relationship: location_of CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 relationship: location_of CCO:B0011127 ! CDN1B_HUMAN-Phosphoserine140 relationship: location_of CCO:B0011147 ! CENPE_HUMAN-Phosphoserine454 relationship: location_of CCO:B0011213 ! CHK1_HUMAN-Phosphoserine296 relationship: location_of CCO:B0011456 ! DDB1_HUMAN-Phosphoserine766 relationship: location_of CCO:B0011563 ! DNL3_HUMAN-Phosphothreonine122 relationship: location_of CCO:B0011567 ! DP13A_HUMAN-Phosphoserine691 relationship: location_of CCO:B0011705 ! EP300_HUMAN-Omega-N-methylated arginine604 relationship: location_of CCO:B0011767 ! ESPL1_HUMAN-Phosphoserine1508 relationship: location_of CCO:B0011889 ! FOXN3_HUMAN-Phosphoserine85 relationship: location_of CCO:B0011980 ! GRLF1_HUMAN-Phosphoserine1179 relationship: location_of CCO:B0012010 ! H2AX_HUMAN-Phosphoserine140 relationship: location_of CCO:B0012169 ! HDAC6_HUMAN-Phosphothreonine30 relationship: location_of CCO:B0012180 ! HEXI1_HUMAN-Phosphoserine97 relationship: location_of CCO:B0012377 ! IMA2_HUMAN-Phosphoserine490 relationship: location_of CCO:B0012414 ! ING4_HUMAN-N6-acetyllysine127 relationship: location_of CCO:B0012594 ! KIF23_HUMAN-Phosphoserine682 relationship: location_of CCO:B0012609 ! KIFC1_HUMAN-Phosphoserine33 relationship: location_of CCO:B0012613 ! KNTC1_HUMAN-Phosphoserine2098 relationship: location_of CCO:B0013012 ! MRE11_HUMAN-Phosphoserine688 relationship: location_of CCO:B0013014 ! MSH2_HUMAN-Phosphoserine860 relationship: location_of CCO:B0013046 ! MTUS1_HUMAN-Phosphoserine1264 relationship: location_of CCO:B0013325 ! NUMA1_HUMAN-Phosphoserine2077 relationship: location_of CCO:B0013453 ! PDCD4_HUMAN-Phosphoserine457 relationship: location_of CCO:B0013606 ! PPM1G_HUMAN-Phosphoserine527 relationship: location_of CCO:B0013617 ! PRS4_HUMAN-Phosphotyrosine439 relationship: location_of CCO:B0013618 ! PSA1_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0013650 ! PTTG1_HUMAN-Phosphoserine165 relationship: location_of CCO:B0013777 ! RBL2_HUMAN-Phosphoserine981 relationship: location_of CCO:B0013808 ! RCC1_HUMAN-Phosphoserine406 relationship: location_of CCO:B0013810 ! RCC2_HUMAN-Phosphothreonine20 relationship: location_of CCO:B0013855 ! RGC32_HUMAN-Phosphothreonine111 relationship: location_of CCO:B0013991 ! SEPT2_HUMAN-Phosphotyrosine17 relationship: location_of CCO:B0014006 ! SEPT7_HUMAN-Phosphoserine423 relationship: location_of CCO:B0014075 ! SMC1B_HUMAN-Phosphoserine883 relationship: location_of CCO:B0014084 ! SMC4_HUMAN-Phosphoserine41 relationship: location_of CCO:B0014253 ! STK11_HUMAN-Phosphoserine428 relationship: location_of CCO:B0014336 ! TERF2_HUMAN-Phosphoserine380 relationship: location_of CCO:B0014347 ! TFDP2_HUMAN-Phosphoserine24 relationship: location_of CCO:B0014413 ! TLK2_HUMAN-Phosphoserine99 relationship: location_of CCO:B0014549 ! TSYL2_HUMAN-Phosphoserine16 relationship: location_of CCO:B0014691 ! WEE1_HUMAN-Phosphoserine139 relationship: location_of CCO:B0014709 ! XPC_HUMAN-Phosphoserine347 relationship: location_of CCO:B0014718 ! XRCC2_HUMAN-Phosphoserine249 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: location_of CCO:B0014766 ! ZWIA_HUMAN-Phosphoserine65 relationship: location_of CCO:B0021356 ! Q8IY91_HUMAN relationship: location_of CCO:B0022308 ! Q1MSW9_HUMAN relationship: location_of CCO:B0024005 ! UBP22_HUMAN relationship: location_of CCO:B0026249 ! ZMY11_HUMAN relationship: location_of CCO:B0026380 ! JUB_HUMAN-Phosphoserine119 relationship: location_of CCO:B0028502 ! ERCC3_HUMAN relationship: location_of CCO:B0030800 ! PSB2_HUMAN relationship: location_of CCO:B0031347 ! NDC80_HUMAN-Phosphoserine165 relationship: location_of CCO:B0032873 ! MND1_HUMAN relationship: location_of CCO:B0034007 ! PSB7_HUMAN relationship: location_of CCO:B0035474 ! PSA5_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0035478 ! PSB1_HUMAN-Phosphotyrosine150 relationship: location_of CCO:B0035935 ! MEN1_HUMAN relationship: location_of CCO:B0035936 ! RNF8_HUMAN relationship: location_of CCO:B0039597 ! PRS10_HUMAN-N-acetylalanine2 relationship: location_of CCO:B0039945 ! CRBL2_HUMAN relationship: location_of CCO:B0039948 ! ZFP42_HUMAN relationship: location_of CCO:B0039949 ! FSD1_HUMAN relationship: location_of CCO:B0039950 ! DCC1_HUMAN relationship: location_of CCO:B0041246 ! PRS7_HUMAN relationship: location_of CCO:B0041257 ! E4F1_HUMAN relationship: location_of CCO:B0041262 ! CTF8_HUMAN relationship: location_of CCO:B0041266 ! CINP_HUMAN relationship: location_of CCO:B0041306 ! HMGA2_HUMAN-Phosphoserine105 relationship: location_of CCO:B0041324 ! PSA4_HUMAN-Phosphoserine13 [Term] id: CCO:C0000253 name: nuclear envelope namespace: cellular_component def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] subset: goslim_generic subset: goslim_plant xref: GO:0005635 xref: GO:0005636 is_a: CCO:C0001360 ! organelle envelope is_a: CCO:C0001847 ! nuclear part relationship: location_of CCO:B0001503 ! DPOLA_HUMAN relationship: part_of CCO:C0000733 ! endomembrane system [Term] id: CCO:C0000254 name: nuclear inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] synonym: "inner envelope" BROAD [] xref: GO:0005637 is_a: CCO:C0000897 ! organelle inner membrane is_a: CCO:C0001358 ! nuclear membrane is_a: CCO:C0001872 ! nuclear membrane part [Term] id: CCO:C0000255 name: lamin filament namespace: cellular_component def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684] synonym: "type V intermediate filament" EXACT [] xref: GO:0005638 is_a: CCO:C0000440 ! intermediate filament is_a: CCO:C0001872 ! nuclear membrane part relationship: part_of CCO:C0000254 ! nuclear inner membrane relationship: part_of CCO:C0000261 ! nuclear lamina [Term] id: CCO:C0000256 name: integral to nuclear inner membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] xref: GO:0005639 is_a: CCO:C0001153 ! intrinsic to nuclear inner membrane is_a: CCO:C0001188 ! integral to organelle membrane [Term] id: CCO:C0000257 name: nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] synonym: "outer envelope" BROAD [] synonym: "perinuclear membrane" EXACT [] xref: GO:0005640 is_a: CCO:C0001358 ! nuclear membrane is_a: CCO:C0001361 ! organelle outer membrane is_a: CCO:C0001872 ! nuclear membrane part relationship: part_of CCO:C0001635 ! nuclear envelope-endoplasmic reticulum network [Term] id: CCO:C0000258 name: nuclear envelope lumen namespace: cellular_component def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai] comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. synonym: "nuclear intermembrane space" EXACT [] synonym: "nuclear membrane lumen" RELATED [] synonym: "perinuclear space" EXACT [] xref: GO:0005641 xref: GO:0005653 is_a: CCO:C0001363 ! organelle envelope lumen is_a: CCO:C0001847 ! nuclear part relationship: part_of CCO:C0000253 ! nuclear envelope [Term] id: CCO:C0000259 name: annulate lamellae namespace: cellular_component def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728] xref: GO:0005642 is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0001635 ! nuclear envelope-endoplasmic reticulum network [Term] id: CCO:C0000260 name: nuclear pore namespace: cellular_component def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] subset: goslim_pir synonym: "NPC" EXACT [] synonym: "nuclear pore complex" EXACT [] synonym: "nuclear pore membrane protein" NARROW [] xref: GO:0005643 xref: GO:0005644 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001872 ! nuclear membrane part is_a: CCO:C0001978 ! pore complex relationship: location_of CCO:B0012377 ! IMA2_HUMAN-Phosphoserine490 [Term] id: CCO:C0000261 name: nuclear lamina namespace: cellular_component def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] xref: GO:0005652 is_a: CCO:C0001847 ! nuclear part relationship: part_of CCO:C0000253 ! nuclear envelope [Term] id: CCO:C0000262 name: nucleoplasm namespace: cellular_component def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] subset: goslim_generic subset: goslim_plant xref: GO:0005654 is_a: CCO:C0001847 ! nuclear part relationship: location_of CCO:B0001345 ! SPT5H_HUMAN relationship: location_of CCO:B0001354 ! UBE2C_HUMAN relationship: location_of CCO:B0001451 ! YETS4_HUMAN relationship: location_of CCO:B0001481 ! HSP1_HUMAN relationship: location_of CCO:B0001482 ! PRM2_HUMAN relationship: location_of CCO:B0001503 ! DPOLA_HUMAN relationship: location_of CCO:B0001519 ! CCNB1_HUMAN relationship: location_of CCO:B0001538 ! CCNA2_HUMAN relationship: location_of CCO:B0001551 ! CCND1_HUMAN relationship: location_of CCO:B0001585 ! TF2H1_HUMAN relationship: location_of CCO:B0001644 ! CDK7_HUMAN relationship: location_of CCO:B0001759 ! CUL1_HUMAN relationship: location_of CCO:B0001781 ! E2F2_HUMAN relationship: location_of CCO:B0002019 ! PCAF_HUMAN relationship: location_of CCO:B0002177 ! APC11_HUMAN relationship: location_of CCO:B0002205 ! MUTYH_HUMAN relationship: location_of CCO:B0002215 ! APC4_HUMAN relationship: location_of CCO:B0002221 ! FBX5_HUMAN relationship: location_of CCO:B0005634 ! SKP1_HUMAN relationship: location_of CCO:B0010653 ! ATM_HUMAN-Phosphothreonine72 relationship: location_of CCO:B0010848 ! BRCA1_HUMAN-Phosphoserine1330 relationship: location_of CCO:B0010859 ! BRCA2_HUMAN-Phosphoserine683 relationship: location_of CCO:B0010903 ! CAF1B_HUMAN-Phosphothreonine495 relationship: location_of CCO:B0010997 ! CCNE2_HUMAN-Phosphothreonine392 relationship: location_of CCO:B0010998 ! CCNH_HUMAN-Phosphoserine5 relationship: location_of CCO:B0011062 ! CDC23_HUMAN-Phosphothreonine559 relationship: location_of CCO:B0011066 ! CDC26_HUMAN-Phosphoserine78 relationship: location_of CCO:B0011074 ! CDC27_HUMAN-Phosphothreonine430 relationship: location_of CCO:B0011087 ! CDC6_HUMAN-Phosphothreonine166 relationship: location_of CCO:B0011105 ! CDK2_HUMAN-Phosphotyrosine19 relationship: location_of CCO:B0011213 ! CHK1_HUMAN-Phosphoserine296 relationship: location_of CCO:B0011456 ! DDB1_HUMAN-Phosphoserine766 relationship: location_of CCO:B0011563 ! DNL3_HUMAN-Phosphothreonine122 relationship: location_of CCO:B0012010 ! H2AX_HUMAN-Phosphoserine140 relationship: location_of CCO:B0012377 ! IMA2_HUMAN-Phosphoserine490 relationship: location_of CCO:B0012594 ! KIF23_HUMAN-Phosphoserine682 relationship: location_of CCO:B0012939 ! MK01_HUMAN-Phosphotyrosine187 relationship: location_of CCO:B0012941 ! MK03_HUMAN-N-acetylalanine2 relationship: location_of CCO:B0013012 ! MRE11_HUMAN-Phosphoserine688 relationship: location_of CCO:B0014336 ! TERF2_HUMAN-Phosphoserine380 relationship: location_of CCO:B0014691 ! WEE1_HUMAN-Phosphoserine139 relationship: location_of CCO:B0014709 ! XPC_HUMAN-Phosphoserine347 relationship: location_of CCO:B0019462 ! UB2D1_HUMAN relationship: location_of CCO:B0028502 ! ERCC3_HUMAN relationship: location_of CCO:B0031342 ! MYO16_HUMAN-Phosphotyrosine1432 relationship: location_of CCO:B0041248 ! UB2E1_HUMAN relationship: part_of CCO:C0001373 ! nuclear lumen [Term] id: CCO:C0000263 name: nucleolar ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] synonym: "nucleolar RNase P complex" EXACT [] xref: GO:0005655 is_a: CCO:C0001042 ! multimeric ribonuclease P complex is_a: CCO:C0001871 ! nucleolar part [Term] id: CCO:C0000264 name: pre-replicative complex namespace: cellular_component def: "A multiprotein complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894] synonym: "pre-RC" EXACT [] xref: GO:0005656 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0000265 name: replication fork namespace: cellular_component def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "replication focus" RELATED [] xref: GO:0005657 is_a: CCO:C0001846 ! chromosomal part relationship: location_of CCO:B0001603 ! BCL6_HUMAN [Term] id: CCO:C0000266 name: alpha DNA polymerase:primase complex namespace: cellular_component def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402] synonym: "DNA polymerase alpha:primase complex" EXACT [] synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT [] synonym: "pol-prim" RELATED [] synonym: "primosome" BROAD [] xref: GO:0005658 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: location_of CCO:B0001503 ! DPOLA_HUMAN relationship: part_of CCO:C0001798 ! nuclear replisome [Term] id: CCO:C0000267 name: DNA replication factor A complex namespace: cellular_component def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] synonym: "replication protein A" EXACT [] synonym: "RPA" EXACT [] synonym: "single-stranded DNA-binding protein complex" RELATED [] synonym: "SSB" RELATED [] xref: GO:0005662 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0001798 ! nuclear replisome [Term] id: CCO:C0000268 name: DNA replication factor C complex namespace: cellular_component def: "A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520] subset: goslim_pir subset: gosubset_prok synonym: "activator 1 complex" EXACT [] synonym: "RFC complex" EXACT [] xref: GO:0005663 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000265 ! replication fork [Term] id: CCO:C0000269 name: nuclear origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] synonym: "eukaryotic ORC" EXACT [] synonym: "nuclear ORC" EXACT [] xref: GO:0005664 is_a: CCO:C0000135 ! origin recognition complex is_a: CCO:C0001873 ! nuclear chromosome part [Term] id: CCO:C0000270 name: DNA-directed RNA polymerase II, core complex namespace: cellular_component def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] xref: GO:0005665 is_a: CCO:C0001870 ! nucleoplasm part is_a: CCO:C0002015 ! nuclear DNA-directed RNA polymerase complex relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0000271 name: DNA-directed RNA polymerase III complex namespace: cellular_component def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase III activity" RELATED [] xref: GO:0005666 is_a: CCO:C0001870 ! nucleoplasm part is_a: CCO:C0002015 ! nuclear DNA-directed RNA polymerase complex [Term] id: CCO:C0000272 name: transcription factor complex namespace: cellular_component def: "Any complex, distinct from RNA polymerase, including one or more polypeptides capable of binding DNA at promoters or at cis-acting regulatory sequences, and regulating transcription." [GOC:mah] subset: goslim_pir xref: GO:0005667 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part relationship: location_of CCO:B0001781 ! E2F2_HUMAN relationship: location_of CCO:B0014347 ! TFDP2_HUMAN-Phosphoserine24 [Term] id: CCO:C0000273 name: selectivity factor SL1 complex namespace: cellular_component def: "A RNA polymerase I-specific protein complex which in humans has two subunits, tata-binding protein (TBP) and TBP-associated factor 1 (TAF1)." [GOC:jl, PMID:9857193] xref: GO:0005668 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0000274 name: transcription factor TFIID complex namespace: cellular_component def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] xref: GO:0005669 is_a: CCO:C0000272 ! transcription factor complex relationship: location_of CCO:B0001959 ! TAF1L_HUMAN relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0000275 name: Ada2/Gcn5/Ada3 transcription activator complex namespace: cellular_component def: "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607] xref: GO:0005671 is_a: CCO:C0000011 ! histone acetyltransferase complex [Term] id: CCO:C0000276 name: transcription factor TFIIA complex namespace: cellular_component def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, UniProtKB:P52655] xref: GO:0005672 is_a: CCO:C0000272 ! transcription factor complex relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0000277 name: transcription factor TFIIE complex namespace: cellular_component def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, UniProtKB:P29083] xref: GO:0005673 is_a: CCO:C0000272 ! transcription factor complex relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0000278 name: transcription factor TFIIF complex namespace: cellular_component def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, UniProtKB:P13984] xref: GO:0005674 is_a: CCO:C0000272 ! transcription factor complex relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0000279 name: holo TFIIH complex namespace: cellular_component def: "A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of XPD, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB." [GOC:krc, PMID:14500720, PMID:7813015, UniProtKB:Q13889] xref: GO:0005675 is_a: CCO:C0000272 ! transcription factor complex relationship: location_of CCO:B0001585 ! TF2H1_HUMAN relationship: location_of CCO:B0028502 ! ERCC3_HUMAN relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0000280 name: chromatin silencing complex namespace: cellular_component def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] xref: GO:0005677 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0000281 name: chromatin assembly complex namespace: cellular_component def: "Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah] xref: GO:0005678 is_a: CCO:C0000806 ! chromatin remodeling complex relationship: location_of CCO:B0010903 ! CAF1B_HUMAN-Phosphothreonine495 [Term] id: CCO:C0000282 name: anaphase-promoting complex namespace: cellular_component def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, PMID:10465783, PMID:10611969] synonym: "anaphase promoting complex" EXACT [] synonym: "APC" EXACT [] synonym: "cyclosome" EXACT [] xref: GO:0005680 is_a: CCO:C0000027 ! nuclear ubiquitin ligase complex relationship: location_of CCO:B0001875 ! HECD3_HUMAN relationship: location_of CCO:B0001888 ! Q5TCY3_HUMAN relationship: location_of CCO:B0002177 ! APC11_HUMAN relationship: location_of CCO:B0002215 ! APC4_HUMAN relationship: location_of CCO:B0011062 ! CDC23_HUMAN-Phosphothreonine559 relationship: location_of CCO:B0011066 ! CDC26_HUMAN-Phosphoserine78 relationship: location_of CCO:B0011074 ! CDC27_HUMAN-Phosphothreonine430 relationship: location_of CCO:B0019420 ! Q53FN2_HUMAN [Term] id: CCO:C0000283 name: spliceosome namespace: cellular_component def: "A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron." [ISBN:0198547684] subset: goslim_pir synonym: "spliceosome complex" EXACT [] xref: GO:0005681 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001847 ! nuclear part relationship: location_of CCO:B0001361 ! O14835_HUMAN relationship: location_of CCO:B0001702 ! TXN4A_HUMAN relationship: location_of CCO:B0002065 ! CDC5L_HUMAN relationship: location_of CCO:B0002172 ! TXN4B_HUMAN [Term] id: CCO:C0000284 name: snRNP U5 namespace: cellular_component def: "Ribonucleoprotein complex containing small nuclear RNA U5; a component of both the major and minor spliceosome complexes." [GOC:krc] xref: GO:0005682 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex relationship: part_of CCO:C0000286 ! U2-dependent spliceosome relationship: part_of CCO:C0000291 ! U12-dependent spliceosome [Term] id: CCO:C0000285 name: snRNP U7 namespace: cellular_component def: "A ribonucleoprotein complex, that includes the U7 snRNA, required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004] xref: GO:0005683 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex [Term] id: CCO:C0000286 name: U2-dependent spliceosome namespace: cellular_component def: "The major (U2-dependent) spliceosome is composed of five snRNP complexes (U1, U2, U4, U5, and U6) as well as many non-snRNP proteins. It acts through many RNA-RNA, RNA-protein, and protein-protein interactions to precisely excise each intron and join the flanking exons." [PMID:11343900] synonym: "GT-AG spliceosome" EXACT [] synonym: "major (U2-dependent) spliceosome" EXACT [] synonym: "major spliceosome" EXACT [] xref: GO:0005684 is_a: CCO:C0000283 ! spliceosome [Term] id: CCO:C0000287 name: snRNP U1 namespace: cellular_component def: "Ribonucleoprotein complex containing small nuclear RNA U1; a component of the major spliceosome complex." [GOC:krc] xref: GO:0005685 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex relationship: part_of CCO:C0000286 ! U2-dependent spliceosome [Term] id: CCO:C0000288 name: snRNP U2 namespace: cellular_component def: "Ribonucleoprotein complex containing small nuclear RNA U2; a component of the major spliceosome complex." [GOC:krc] xref: GO:0005686 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex relationship: part_of CCO:C0000286 ! U2-dependent spliceosome [Term] id: CCO:C0000289 name: snRNP U4 namespace: cellular_component def: "Ribonucleoprotein complex containing small nuclear RNA U4; a component of the major spliceosome complex." [GOC:krc] xref: GO:0005687 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex relationship: part_of CCO:C0000286 ! U2-dependent spliceosome [Term] id: CCO:C0000290 name: snRNP U6 namespace: cellular_component def: "Ribonucleoprotein complex containing small nuclear RNA U6; a component of the major spliceosome complex." [GOC:krc] xref: GO:0005688 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex relationship: part_of CCO:C0000286 ! U2-dependent spliceosome [Term] id: CCO:C0000291 name: U12-dependent spliceosome namespace: cellular_component def: "The minor (U12-dependent) spliceosome is composed of the snRNPs, U11, U12, U4atac, U6atac, and U5 (which is also a component of the major spliceosome). This minor form of the spliceosome is responsible for the splicing of the majority of introns with atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [PMID:11574683, PMID:11971955] synonym: "AT-AC spliceosome" EXACT [] synonym: "minor (U12-dependent) spliceosome complex" EXACT [] synonym: "minor spliceosome" EXACT [] xref: GO:0005689 is_a: CCO:C0000283 ! spliceosome [Term] id: CCO:C0000292 name: snRNP U4atac namespace: cellular_component def: "Ribonucleoprotein complex containing small nuclear RNA U4atac; a component of the minor spliceosome complex." [GOC:krc] xref: GO:0005690 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex relationship: part_of CCO:C0000291 ! U12-dependent spliceosome [Term] id: CCO:C0000293 name: snRNP U6atac namespace: cellular_component def: "Ribonucleoprotein complex containing small nuclear RNA U6atac; a component of the minor spliceosome complex." [GOC:krc] xref: GO:0005691 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex relationship: part_of CCO:C0000291 ! U12-dependent spliceosome [Term] id: CCO:C0000294 name: snRNP U11 namespace: cellular_component def: "Ribonucleoprotein complex containing small nuclear RNA U11; a component of the minor spliceosome complex." [GOC:krc] xref: GO:0005692 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex relationship: part_of CCO:C0000291 ! U12-dependent spliceosome [Term] id: CCO:C0000295 name: snRNP U12 namespace: cellular_component def: "Ribonucleoprotein complex containing small nuclear RNA U12; a component of the minor spliceosome complex." [GOC:krc] xref: GO:0005693 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex relationship: part_of CCO:C0000291 ! U12-dependent spliceosome [Term] id: CCO:C0000296 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: GO:0005694 is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: location_of CCO:B0001337 ! A6NLT8_HUMAN relationship: location_of CCO:B0001391 ! SUV91_HUMAN relationship: location_of CCO:B0001450 ! SMC2_HUMAN relationship: location_of CCO:B0001481 ! HSP1_HUMAN relationship: location_of CCO:B0001482 ! PRM2_HUMAN relationship: location_of CCO:B0001886 ! Q5TCH6_HUMAN relationship: location_of CCO:B0001887 ! Q5TCH7_HUMAN relationship: location_of CCO:B0002149 ! PRM3_HUMAN relationship: location_of CCO:B0010824 ! BOREA_HUMAN-Phosphoserine165 relationship: location_of CCO:B0012010 ! H2AX_HUMAN-Phosphoserine140 relationship: location_of CCO:B0014075 ! SMC1B_HUMAN-Phosphoserine883 relationship: location_of CCO:B0014084 ! SMC4_HUMAN-Phosphoserine41 relationship: location_of CCO:B0014336 ! TERF2_HUMAN-Phosphoserine380 relationship: location_of CCO:B0041306 ! HMGA2_HUMAN-Phosphoserine105 [Term] id: CCO:C0000297 name: telomerase holoenzyme complex namespace: cellular_component def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619] subset: goslim_pir xref: GO:0005697 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000298 name: polytene chromosome namespace: cellular_component def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005700 is_a: CCO:C0000296 ! chromosome [Term] id: CCO:C0000299 name: polytene chromosome chromocenter namespace: cellular_component def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome chromocentre" EXACT [] xref: GO:0005701 is_a: CCO:C0000730 ! chromocenter relationship: part_of CCO:C0000298 ! polytene chromosome [Term] id: CCO:C0000300 name: polytene chromosome weak point namespace: cellular_component def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012] synonym: "constriction" BROAD [] xref: GO:0005702 is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000298 ! polytene chromosome [Term] id: CCO:C0000301 name: polytene chromosome puff namespace: cellular_component def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] xref: GO:0005703 is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000298 ! polytene chromosome [Term] id: CCO:C0000302 name: polytene chromosome band namespace: cellular_component def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] xref: GO:0005704 is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000298 ! polytene chromosome [Term] id: CCO:C0000303 name: polytene chromosome interband namespace: cellular_component def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] xref: GO:0005705 is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000298 ! polytene chromosome [Term] id: CCO:C0000304 name: polytene chromosome ectopic fiber namespace: cellular_component def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome ectopic fibre" EXACT [] xref: GO:0005706 is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000298 ! polytene chromosome [Term] id: CCO:C0000305 name: chiasma namespace: cellular_component def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005712 is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000121 ! condensed nuclear chromosome [Term] id: CCO:C0000306 name: recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh] xref: GO:0005713 is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000121 ! condensed nuclear chromosome [Term] id: CCO:C0000307 name: early recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh] xref: GO:0005714 is_a: CCO:C0000306 ! recombination nodule [Term] id: CCO:C0000308 name: late recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh] xref: GO:0005715 is_a: CCO:C0000306 ! recombination nodule [Term] id: CCO:C0000309 name: nuclear euchromatin namespace: cellular_component def: "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005719 is_a: CCO:C0000117 ! nuclear chromatin is_a: CCO:C0000118 ! euchromatin [Term] id: CCO:C0000310 name: nuclear heterochromatin namespace: cellular_component def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005720 is_a: CCO:C0000117 ! nuclear chromatin is_a: CCO:C0000119 ! heterochromatin [Term] id: CCO:C0000311 name: centric heterochromatin namespace: cellular_component def: "A region of heterochromatin located near the centromere of a chromosome." [PMID:12019236] synonym: "centromeric heterochromatin" EXACT [] xref: GO:0005721 is_a: CCO:C0000119 ! heterochromatin relationship: part_of CCO:C0000102 ! chromosome, pericentric region [Term] id: CCO:C0000312 name: beta-heterochromatin namespace: cellular_component def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678] xref: GO:0005722 is_a: CCO:C0000311 ! centric heterochromatin relationship: part_of CCO:C0000299 ! polytene chromosome chromocenter [Term] id: CCO:C0000313 name: alpha-heterochromatin namespace: cellular_component def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678] xref: GO:0005723 is_a: CCO:C0000311 ! centric heterochromatin relationship: part_of CCO:C0000299 ! polytene chromosome chromocenter [Term] id: CCO:C0000314 name: nuclear telomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai] xref: GO:0005724 is_a: CCO:C0000310 ! nuclear heterochromatin is_a: CCO:C0001354 ! telomeric heterochromatin relationship: part_of CCO:C0000111 ! nuclear chromosome, telomeric region [Term] id: CCO:C0000315 name: intercalary heterochromatin namespace: cellular_component def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] xref: GO:0005725 is_a: CCO:C0000310 ! nuclear heterochromatin [Term] id: CCO:C0000316 name: perichromatin fibrils namespace: cellular_component def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598] xref: GO:0005726 is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000117 ! nuclear chromatin [Term] id: CCO:C0000317 name: extrachromosomal circular DNA namespace: cellular_component def: "Circular DNA structures that are not part of a chromosome." [GOC:ai] subset: gosubset_prok xref: GO:0005727 is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0001971 ! extrachromosomal DNA [Term] id: CCO:C0000318 name: extrachromosomal rDNA circle namespace: cellular_component def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934] synonym: "extrachromosomal ribosomal DNA circle" EXACT [] xref: GO:0005728 is_a: CCO:C0000317 ! extrachromosomal circular DNA [Term] id: CCO:C0000319 name: 2-micrometer circle DNA namespace: cellular_component def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320] xref: GO:0005729 is_a: CCO:C0000317 ! extrachromosomal circular DNA [Term] id: CCO:C0000320 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: GO:0005730 is_a: CCO:C0001847 ! nuclear part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: location_of CCO:B0001503 ! DPOLA_HUMAN relationship: location_of CCO:B0010800 ! BLM_HUMAN-Phosphoserine419 relationship: location_of CCO:B0014549 ! TSYL2_HUMAN-Phosphoserine16 relationship: part_of CCO:C0001373 ! nuclear lumen [Term] id: CCO:C0000321 name: nucleolus organizer region namespace: cellular_component def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406] synonym: "NOR" EXACT [] synonym: "nucleolus organiser region" EXACT [] synonym: "nucleolus organizer complex" RELATED [] xref: GO:0005731 is_a: CCO:C0001064 ! nucleolar chromatin is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000322 name: small nucleolar ribonucleoprotein complex namespace: cellular_component def: "A complex composed of RNA of the small nucleolar RNA (snoRNA) and protein, found in the nucleolus of a eukaryotic cell. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897] subset: goslim_pir synonym: "small nucleolar ribonucleoprotein" EXACT [] synonym: "snoRNP" EXACT [] xref: GO:0005732 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001871 ! nucleolar part [Term] id: CCO:C0000323 name: DNA-directed RNA polymerase I complex namespace: cellular_component def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase I activity" RELATED [] xref: GO:0005736 is_a: CCO:C0001871 ! nucleolar part is_a: CCO:C0002015 ! nuclear DNA-directed RNA polymerase complex [Term] id: CCO:C0000324 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0005737 is_a: CCO:C0001843 ! intracellular part relationship: location_of CCO:B0001353 ! PPP6_HUMAN relationship: location_of CCO:B0001355 ! CDKA1_HUMAN relationship: location_of CCO:B0001370 ! FANCG_HUMAN relationship: location_of CCO:B0001401 ! GAS2_HUMAN relationship: location_of CCO:B0001419 ! HUS1_HUMAN relationship: location_of CCO:B0001450 ! SMC2_HUMAN relationship: location_of CCO:B0001458 ! BCL10_HUMAN relationship: location_of CCO:B0001496 ! FUMH_HUMAN relationship: location_of CCO:B0001519 ! CCNB1_HUMAN relationship: location_of CCO:B0001523 ! PGDH_HUMAN relationship: location_of CCO:B0001524 ! NDKA_HUMAN relationship: location_of CCO:B0001538 ! CCNA2_HUMAN relationship: location_of CCO:B0001546 ! NDKB_HUMAN relationship: location_of CCO:B0001595 ! AHR_HUMAN relationship: location_of CCO:B0001596 ! PP1G_HUMAN relationship: location_of CCO:B0001662 ! PPP5_HUMAN relationship: location_of CCO:B0001681 ! SESN2_HUMAN relationship: location_of CCO:B0001684 ! MLF1_HUMAN relationship: location_of CCO:B0001737 ! STRN3_HUMAN relationship: location_of CCO:B0001758 ! ULA1_HUMAN relationship: location_of CCO:B0001799 ! MD2BP_HUMAN relationship: location_of CCO:B0001802 ! CD5R1_HUMAN relationship: location_of CCO:B0001825 ! TPD53_HUMAN relationship: location_of CCO:B0001831 ! Q3LRW5_HUMAN relationship: location_of CCO:B0001899 ! DAB2P_HUMAN relationship: location_of CCO:B0001972 ! BOLL_HUMAN relationship: location_of CCO:B0001980 ! DP13B_HUMAN relationship: location_of CCO:B0001981 ! FLCN_HUMAN relationship: location_of CCO:B0001985 ! GA2L2_HUMAN relationship: location_of CCO:B0002012 ! RSPH1_HUMAN relationship: location_of CCO:B0002026 ! NAT6_HUMAN relationship: location_of CCO:B0002049 ! HEXI2_HUMAN relationship: location_of CCO:B0002065 ! CDC5L_HUMAN relationship: location_of CCO:B0002071 ! MPH6_HUMAN relationship: location_of CCO:B0002086 ! BARD1_HUMAN relationship: location_of CCO:B0002094 ! LZTS2_HUMAN relationship: location_of CCO:B0002099 ! CP250_HUMAN relationship: location_of CCO:B0002112 ! PAR6G_HUMAN relationship: location_of CCO:B0002114 ! Q9BYG9_HUMAN relationship: location_of CCO:B0002119 ! AL2S2_HUMAN relationship: location_of CCO:B0002133 ! TXNIP_HUMAN relationship: location_of CCO:B0002148 ! CHM1A_HUMAN relationship: location_of CCO:B0002150 ! PAR6A_HUMAN relationship: location_of CCO:B0002156 ! BIN3_HUMAN relationship: location_of CCO:B0002177 ! APC11_HUMAN relationship: location_of CCO:B0002180 ! GTSE1_HUMAN relationship: location_of CCO:B0002183 ! SEP10_HUMAN relationship: location_of CCO:B0002206 ! HERC5_HUMAN relationship: location_of CCO:B0002221 ! FBX5_HUMAN relationship: location_of CCO:B0002228 ! ASC_HUMAN relationship: location_of CCO:B0002257 ! CD2AP_HUMAN relationship: location_of CCO:B0006215 ! PSME1_HUMAN relationship: location_of CCO:B0010567 ! APC_HUMAN-Phosphoserine1038 relationship: location_of CCO:B0010628 ! ASPP1_HUMAN-Phosphoserine332 relationship: location_of CCO:B0010824 ! BOREA_HUMAN-Phosphoserine165 relationship: location_of CCO:B0010903 ! CAF1B_HUMAN-Phosphothreonine495 relationship: location_of CCO:B0010926 ! CASL_HUMAN-Phosphotyrosine166 relationship: location_of CCO:B0011074 ! CDC27_HUMAN-Phosphothreonine430 relationship: location_of CCO:B0011082 ! CDC37_HUMAN-Phosphotyrosine298 relationship: location_of CCO:B0011087 ! CDC6_HUMAN-Phosphothreonine166 relationship: location_of CCO:B0011092 ! CDCA3_HUMAN-Phosphoserine68 relationship: location_of CCO:B0011098 ! CDCA5_HUMAN-Phosphothreonine48 relationship: location_of CCO:B0011105 ! CDK2_HUMAN-Phosphotyrosine19 relationship: location_of CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 relationship: location_of CCO:B0011127 ! CDN1B_HUMAN-Phosphoserine140 relationship: location_of CCO:B0011213 ! CHK1_HUMAN-Phosphoserine296 relationship: location_of CCO:B0011263 ! CLIP1_HUMAN-Phosphoserine200 relationship: location_of CCO:B0011406 ! CTRO_HUMAN-Phosphoserine440 relationship: location_of CCO:B0011452 ! DCTN1_HUMAN-Phosphoserine541 relationship: location_of CCO:B0011456 ! DDB1_HUMAN-Phosphoserine766 relationship: location_of CCO:B0011567 ! DP13A_HUMAN-Phosphoserine691 relationship: location_of CCO:B0011767 ! ESPL1_HUMAN-Phosphoserine1508 relationship: location_of CCO:B0011882 ! FHIT_HUMAN-Phosphotyrosine145 relationship: location_of CCO:B0011980 ! GRLF1_HUMAN-Phosphoserine1179 relationship: location_of CCO:B0012169 ! HDAC6_HUMAN-Phosphothreonine30 relationship: location_of CCO:B0012180 ! HEXI1_HUMAN-Phosphoserine97 relationship: location_of CCO:B0012377 ! IMA2_HUMAN-Phosphoserine490 relationship: location_of CCO:B0012613 ! KNTC1_HUMAN-Phosphoserine2098 relationship: location_of CCO:B0012757 ! MADD_HUMAN-Phosphoserine1059 relationship: location_of CCO:B0013133 ! NDE1_HUMAN-Phosphoserine306 relationship: location_of CCO:B0013453 ! PDCD4_HUMAN-Phosphoserine457 relationship: location_of CCO:B0013606 ! PPM1G_HUMAN-Phosphoserine527 relationship: location_of CCO:B0013617 ! PRS4_HUMAN-Phosphotyrosine439 relationship: location_of CCO:B0013618 ! PSA1_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0013650 ! PTTG1_HUMAN-Phosphoserine165 relationship: location_of CCO:B0013808 ! RCC1_HUMAN-Phosphoserine406 relationship: location_of CCO:B0013855 ! RGC32_HUMAN-Phosphothreonine111 relationship: location_of CCO:B0013991 ! SEPT2_HUMAN-Phosphotyrosine17 relationship: location_of CCO:B0014084 ! SMC4_HUMAN-Phosphoserine41 relationship: location_of CCO:B0014164 ! SPAG5_HUMAN-Phosphoserine249 relationship: location_of CCO:B0014253 ! STK11_HUMAN-Phosphoserine428 relationship: location_of CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 relationship: location_of CCO:B0014549 ! TSYL2_HUMAN-Phosphoserine16 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: location_of CCO:B0014766 ! ZWIA_HUMAN-Phosphoserine65 relationship: location_of CCO:B0022308 ! Q1MSW9_HUMAN relationship: location_of CCO:B0026255 ! KLDC3_HUMAN relationship: location_of CCO:B0026256 ! RPRM_HUMAN relationship: location_of CCO:B0026380 ! JUB_HUMAN-Phosphoserine119 relationship: location_of CCO:B0030800 ! PSB2_HUMAN relationship: location_of CCO:B0031342 ! MYO16_HUMAN-Phosphotyrosine1432 relationship: location_of CCO:B0034007 ! PSB7_HUMAN relationship: location_of CCO:B0035474 ! PSA5_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0035478 ! PSB1_HUMAN-Phosphotyrosine150 relationship: location_of CCO:B0035935 ! MEN1_HUMAN relationship: location_of CCO:B0035990 ! CCNG2_HUMAN-Phosphoserine220 relationship: location_of CCO:B0036017 ! MYH10_HUMAN-Phosphothreonine1376 relationship: location_of CCO:B0039597 ! PRS10_HUMAN-N-acetylalanine2 relationship: location_of CCO:B0039947 ! STRA8_HUMAN relationship: location_of CCO:B0039948 ! ZFP42_HUMAN relationship: location_of CCO:B0039949 ! FSD1_HUMAN relationship: location_of CCO:B0041172 ! PP1A_HUMAN-Phosphothreonine320 relationship: location_of CCO:B0041246 ! PRS7_HUMAN relationship: location_of CCO:B0041257 ! E4F1_HUMAN relationship: location_of CCO:B0041261 ! ERF3B_HUMAN relationship: location_of CCO:B0041324 ! PSA4_HUMAN-Phosphoserine13 [Term] id: CCO:C0000325 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: GO:0005739 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle relationship: location_of CCO:B0001496 ! FUMH_HUMAN relationship: location_of CCO:B0002132 ! Q9H315_HUMAN relationship: location_of CCO:B0013046 ! MTUS1_HUMAN-Phosphoserine1264 [Term] id: CCO:C0000326 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast xref: GO:0005740 is_a: CCO:C0001360 ! organelle envelope is_a: CCO:C0001848 ! mitochondrial part [Term] id: CCO:C0000327 name: mitochondrial outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] xref: GO:0005741 is_a: CCO:C0001359 ! mitochondrial membrane is_a: CCO:C0001361 ! organelle outer membrane [Term] id: CCO:C0000328 name: mitochondrial outer membrane translocase complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629] synonym: "GIP complex" NARROW [] synonym: "TOM complex" NARROW [] xref: GO:0005742 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000327 ! mitochondrial outer membrane [Term] id: CCO:C0000329 name: mitochondrial inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] xref: GO:0005743 is_a: CCO:C0000897 ! organelle inner membrane is_a: CCO:C0001359 ! mitochondrial membrane [Term] id: CCO:C0000330 name: mitochondrial inner membrane presequence translocase complex namespace: cellular_component def: "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. subset: goslim_pir synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT [] synonym: "mitochondrial inner membrane translocase complex" EXACT [] synonym: "Tim23 complex" NARROW [] xref: GO:0005744 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0000331 name: m-AAA complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [PMID:12417197] xref: GO:0005745 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0000332 name: mitochondrial respiratory chain namespace: cellular_component def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain). Complexes I, III and IV can transport protons if embedded in an oriented membrane, such as an intact mitochondrial inner membrane." [ISBN:0198547684] synonym: "mitochondrial electron transport chain" EXACT [] xref: GO:0005746 is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0000333 name: mitochondrial respiratory chain complex I namespace: cellular_component def: "A part of the respiratory chain located in the mitochondrion. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] synonym: "NADH dehydrogenase complex (ubiquinone) (sensu Eukaryota)" EXACT [] synonym: "respiratory chain complex I (sensu Eukaryota)" EXACT [] xref: GO:0005747 xref: GO:0005748 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001932 ! respiratory chain complex I relationship: part_of CCO:C0000332 ! mitochondrial respiratory chain [Term] id: CCO:C0000334 name: mitochondrial respiratory chain complex II namespace: cellular_component def: "A part of the respiratory chain located in the mitochondrion, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, ISBN:0198547684] synonym: "fumarate reductase complex (sensu Eukaryota)" EXACT [] synonym: "mitochondrial fumarate reductase complex" EXACT [] synonym: "respiratory chain complex II (sensu Eukaryota)" EXACT [] synonym: "succinate dehydrogenase complex (sensu Eukaryota)" EXACT [] synonym: "succinate dehydrogenase complex (ubiquinone) (sensu Eukaryota)" EXACT [] xref: GO:0005749 xref: GO:0008136 xref: GO:0009362 xref: GO:0019738 xref: GO:0030390 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001918 ! succinate dehydrogenase complex (ubiquinone) is_a: CCO:C0001943 ! fumarate reductase complex relationship: part_of CCO:C0000332 ! mitochondrial respiratory chain [Term] id: CCO:C0000335 name: mitochondrial respiratory chain complex III namespace: cellular_component def: "A part of the respiratory chain located in the mitochondrion, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] synonym: "respiratory chain complex III (sensu Eukaryota)" EXACT [] synonym: "ubiquinol-cytochrome c oxidoreductase complex (sensu Eukaryota)" EXACT [] synonym: "ubiquinol-cytochrome-c reductase complex (sensu Eukaryota)" EXACT [] xref: GO:0005750 xref: GO:0015008 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001936 ! respiratory chain complex III relationship: part_of CCO:C0000332 ! mitochondrial respiratory chain [Term] id: CCO:C0000336 name: mitochondrial respiratory chain complex IV namespace: cellular_component def: "A part of the respiratory chain located in the mitochondrion, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Found in eukaryotes." [GOC:mtg_sensu, ISBN:0198547684] synonym: "cytochrome c oxidase complex (sensu Eukaryota)" EXACT [] synonym: "respiratory chain complex IV (sensu Eukaryota)" EXACT [] xref: GO:0005751 xref: GO:0005752 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001938 ! respiratory chain complex IV relationship: part_of CCO:C0000332 ! mitochondrial respiratory chain [Term] id: CCO:C0000337 name: mitochondrial proton-transporting ATP synthase complex namespace: cellular_component def: "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu] synonym: "hydrogen-translocating F-type ATPase complex (sensu Eukaryota)" EXACT [] synonym: "hydrogen-transporting ATP synthase" BROAD [] synonym: "proton-transporting ATP synthase complex (sensu Eukaryota)" EXACT [] synonym: "respiratory chain complex V (sensu Eukaryota)" EXACT [] xref: GO:0005753 xref: GO:0016470 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001920 ! proton-transporting ATP synthase complex relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0000338 name: mitochondrial proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056] synonym: "hydrogen-transporting ATP synthase, catalytic core (sensu Eukaryota)" EXACT [] synonym: "proton-transporting ATP synthase, catalytic core (sensu Eukaryota)" EXACT [] xref: GO:0005754 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001928 ! proton-transporting ATP synthase, catalytic core relationship: part_of CCO:C0000048 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: CCO:C0000339 name: mitochondrial proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056] synonym: "hydrogen-transporting ATP synthase, central stalk (sensu Eukaryota)" EXACT [] synonym: "proton-transporting ATP synthase, central stalk (sensu Eukaryota)" EXACT [] xref: GO:0005756 is_a: CCO:C0001874 ! mitochondrial membrane part is_a: CCO:C0001930 ! proton-transporting ATP synthase, central stalk relationship: part_of CCO:C0000048 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: CCO:C0000340 name: mitochondrial permeability transition pore complex namespace: cellular_component def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol." [PMID:10393078] synonym: "mitochondrial PT pore complex" EXACT [] xref: GO:0005757 is_a: CCO:C0001848 ! mitochondrial part is_a: CCO:C0001978 ! pore complex relationship: part_of CCO:C0000326 ! mitochondrial envelope [Term] id: CCO:C0000341 name: mitochondrial intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] synonym: "mitochondrial envelope lumen" EXACT [] synonym: "mitochondrial membrane lumen" RELATED [] xref: GO:0005758 xref: GO:0031971 is_a: CCO:C0001363 ! organelle envelope lumen is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000326 ! mitochondrial envelope [Term] id: CCO:C0000342 name: mitochondrial matrix namespace: cellular_component def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty-acid oxidation." [GOC:as, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "mitochondrial stroma" NARROW [] xref: GO:0005759 is_a: CCO:C0001848 ! mitochondrial part relationship: location_of CCO:B0001496 ! FUMH_HUMAN relationship: part_of CCO:C0001372 ! mitochondrial lumen [Term] id: CCO:C0000343 name: gamma DNA polymerase complex namespace: cellular_component def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093] xref: GO:0005760 is_a: CCO:C0001651 ! DNA polymerase complex is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000344 name: mitochondrial ribosome namespace: cellular_component def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005761 is_a: CCO:C0000057 ! organellar ribosome is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000345 name: mitochondrial large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] xref: GO:0005762 is_a: CCO:C0000059 ! organellar large ribosomal subunit is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000344 ! mitochondrial ribosome [Term] id: CCO:C0000346 name: mitochondrial small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] xref: GO:0005763 is_a: CCO:C0000058 ! organellar small ribosomal subunit is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000344 ! mitochondrial ribosome [Term] id: CCO:C0000347 name: lysosome namespace: cellular_component def: "Any of a group of related cytoplasmic, membrane bound organelles that are found in most animal cells and that contain a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_plant xref: GO:0005764 is_a: CCO:C0000061 ! lytic vacuole relationship: location_of CCO:B0001458 ! BCL10_HUMAN [Term] id: CCO:C0000348 name: lysosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] xref: GO:0005765 is_a: CCO:C0000356 ! vacuolar membrane relationship: part_of CCO:C0000347 ! lysosome [Term] id: CCO:C0000349 name: primary lysosome namespace: cellular_component def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0005766 is_a: CCO:C0000347 ! lysosome [Term] id: CCO:C0000350 name: secondary lysosome namespace: cellular_component def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0005767 is_a: CCO:C0000347 ! lysosome [Term] id: CCO:C0000351 name: endosome namespace: cellular_component def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pir subset: goslim_plant xref: GO:0005768 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle relationship: location_of CCO:B0001903 ! STEA3_HUMAN relationship: location_of CCO:B0001980 ! DP13B_HUMAN relationship: location_of CCO:B0002148 ! CHM1A_HUMAN relationship: location_of CCO:B0011263 ! CLIP1_HUMAN-Phosphoserine200 relationship: location_of CCO:B0011567 ! DP13A_HUMAN-Phosphoserine691 relationship: location_of CCO:B0012609 ! KIFC1_HUMAN-Phosphoserine33 [Term] id: CCO:C0000352 name: early endosome namespace: cellular_component def: "Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered." [GOC:rb] xref: GO:0005769 is_a: CCO:C0000351 ! endosome relationship: location_of CCO:B0002148 ! CHM1A_HUMAN relationship: location_of CCO:B0012609 ! KIFC1_HUMAN-Phosphoserine33 [Term] id: CCO:C0000353 name: late endosome namespace: cellular_component def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [PMID:11964142, PMID:2557062] synonym: "prevacuolar compartment" EXACT [] synonym: "PVC" BROAD [] xref: GO:0005770 is_a: CCO:C0000351 ! endosome [Term] id: CCO:C0000354 name: multivesicular body namespace: cellular_component def: "A type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881] synonym: "multivesicular endosome" EXACT [PMID:12122203] synonym: "MVB" EXACT [] synonym: "MVE" EXACT [PMID:12122203] xref: GO:0005771 is_a: CCO:C0000353 ! late endosome [Term] id: CCO:C0000355 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: GO:0005773 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0000356 name: vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] subset: gosubset_prok xref: GO:0005774 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001856 ! vacuolar part [Term] id: CCO:C0000357 name: vacuolar lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005775 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001856 ! vacuolar part [Term] id: CCO:C0000358 name: autophagic vacuole namespace: cellular_component def: "A double-membrane bound vesicle in which endogenous cellular material is sequestered; known as autophagosome in yeast." [ISBN:0198547684, PMID:11099404] synonym: "autophagosome" EXACT [] xref: GO:0005776 is_a: CCO:C0000355 ! vacuole [Term] id: CCO:C0000359 name: peroxisome namespace: cellular_component def: "A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [ISBN:0815316194] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "peroxisome vesicle" BROAD [] xref: GO:0005777 xref: GO:0019818 is_a: CCO:C0001652 ! microbody [Term] id: CCO:C0000360 name: peroxisomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a peroxisome." [GOC:mah] synonym: "peroxisome membrane" EXACT [] xref: GO:0005778 is_a: CCO:C0001341 ! microbody membrane is_a: CCO:C0001858 ! peroxisomal part [Term] id: CCO:C0000361 name: integral to peroxisomal membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0005779 is_a: CCO:C0001155 ! intrinsic to peroxisomal membrane is_a: CCO:C0001188 ! integral to organelle membrane [Term] id: CCO:C0000362 name: extrinsic to intraperoxisomal membrane namespace: cellular_component def: "Loosely bound to the intraperoxisomal surface of the peroxisomal membrane, but not integrated into the hydrophobic region." [GOC:mah] synonym: "intra-peroxisomal peripheral membrane" RELATED [] xref: GO:0005780 is_a: CCO:C0001199 ! extrinsic to organelle membrane is_a: CCO:C0001858 ! peroxisomal part relationship: part_of CCO:C0000360 ! peroxisomal membrane [Term] id: CCO:C0000363 name: peroxisomal matrix namespace: cellular_component def: "The material contained within the membrane of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:mah, ISBN:0815316194] xref: GO:0005782 is_a: CCO:C0001858 ! peroxisomal part [Term] id: CCO:C0000364 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "ER" EXACT [] xref: GO:0005783 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle relationship: location_of CCO:B0001428 ! ERN1_HUMAN relationship: location_of CCO:B0001806 ! DHC24_HUMAN relationship: location_of CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: location_of CCO:B0036023 ! PR15A_HUMAN-Phosphoserine264 [Term] id: CCO:C0000365 name: translocon complex namespace: cellular_component def: "A translocation complex that constitutes the specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. Composed of a heterotetramer of alpha, beta, gamma and delta subunits (translocon-associated proteins or TRAPs). In yeast it is a heterotrimeric complex consisting of Sec61p, Sbh1p, and Sss1p. The Sec61 complex functions in cotranslational and posttranslational translocation events." [GOC:rb, ISBN:0198599471] subset: goslim_pir synonym: "sec61 complex" NARROW [] xref: GO:0005784 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0001057 ! rough endoplasmic reticulum membrane [Term] id: CCO:C0000366 name: signal recognition particle receptor complex namespace: cellular_component def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "docking protein complex" RELATED [] synonym: "SR complex" EXACT [] xref: GO:0005785 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0001057 ! rough endoplasmic reticulum membrane [Term] id: CCO:C0000367 name: signal recognition particle, endoplasmic reticulum targeting namespace: cellular_component def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "signal recognition particle (sensu Eukaryota)" EXACT [] synonym: "signal sequence receptor complex" EXACT [] synonym: "SRP" EXACT [] xref: GO:0005786 xref: GO:0005855 is_a: CCO:C0002002 ! signal recognition particle [Term] id: CCO:C0000368 name: signal peptidase complex namespace: cellular_component def: "A multi subunit protease complex located in the endoplasmic reticulum membrane that cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509] xref: GO:0005787 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0000369 name: endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] synonym: "cisternal lumen" EXACT [] synonym: "ER lumen" EXACT [] xref: GO:0005788 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001851 ! endoplasmic reticulum part [Term] id: CCO:C0000370 name: endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] synonym: "ER membrane" EXACT [] xref: GO:0005789 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: location_of CCO:B0001428 ! ERN1_HUMAN relationship: location_of CCO:B0001806 ! DHC24_HUMAN relationship: location_of CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: part_of CCO:C0001635 ! nuclear envelope-endoplasmic reticulum network [Term] id: CCO:C0000371 name: smooth endoplasmic reticulum namespace: cellular_component def: "The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "smooth ER" EXACT [] xref: GO:0005790 is_a: CCO:C0000364 ! endoplasmic reticulum [Term] id: CCO:C0000372 name: rough endoplasmic reticulum namespace: cellular_component def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "rough ER" EXACT [] xref: GO:0005791 is_a: CCO:C0000364 ! endoplasmic reticulum [Term] id: CCO:C0000373 name: microsome namespace: cellular_component def: "Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. synonym: "microsomal membrane" RELATED [] xref: GO:0005792 is_a: CCO:C0001663 ! vesicular fraction [Term] id: CCO:C0000374 name: ER-Golgi intermediate compartment namespace: cellular_component def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [PMID:16723730] synonym: "endoplasmic reticulum-Golgi intermediate compartment" EXACT [] synonym: "ERGIC" EXACT [] synonym: "pre-Golgi intermediate compartment" EXACT [] xref: GO:0005793 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000375 name: Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: GO:0005794 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle relationship: location_of CCO:B0001806 ! DHC24_HUMAN relationship: location_of CCO:B0002175 ! NSMA2_HUMAN relationship: location_of CCO:B0010926 ! CASL_HUMAN-Phosphotyrosine166 relationship: location_of CCO:B0013046 ! MTUS1_HUMAN-Phosphoserine1264 [Term] id: CCO:C0000376 name: Golgi stack namespace: cellular_component def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] synonym: "dictyosome" NARROW [] synonym: "Golgi cisternae" EXACT [] xref: GO:0005795 xref: GO:0016940 is_a: CCO:C0001850 ! Golgi apparatus part [Term] id: CCO:C0000377 name: Golgi lumen namespace: cellular_component def: "The volume enclosed by the membranes of any cisterna of the Golgi apparatus." [GOC:mah] xref: GO:0005796 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001850 ! Golgi apparatus part relationship: location_of CCO:B0001471 ! TGFB1_HUMAN [Term] id: CCO:C0000378 name: Golgi medial cisterna namespace: cellular_component def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] xref: GO:0005797 is_a: CCO:C0001377 ! Golgi cisterna [Term] id: CCO:C0000379 name: Golgi-associated vesicle namespace: cellular_component def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] comment: Note that this definition includes vesicles that are transiently associated with the Golgi. synonym: "Golgi vesicle" RELATED [] xref: GO:0005798 is_a: CCO:C0001850 ! Golgi apparatus part is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0000380 name: cis-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815316194] synonym: "cis Golgi network" EXACT [] synonym: "forming face" RELATED [] synonym: "Golgi cis face" RELATED [] synonym: "Golgi cis-face" RELATED [] xref: GO:0005801 is_a: CCO:C0001850 ! Golgi apparatus part [Term] id: CCO:C0000381 name: trans-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located at the side of the Golgi apparatus distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] synonym: "Golgi trans face" RELATED [] synonym: "Golgi trans-face" RELATED [] synonym: "maturing face" RELATED [] synonym: "TGN" EXACT [] synonym: "trans Golgi network" EXACT [] xref: GO:0005802 is_a: CCO:C0001850 ! Golgi apparatus part [Term] id: CCO:C0000382 name: lipid particle namespace: cellular_component def: "Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins." [GOC:mah] comment: Note that this term does not refer to vesicle, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid droplet" EXACT [] xref: GO:0005811 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000383 name: centrosome namespace: cellular_component def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] subset: goslim_pir xref: GO:0005813 is_a: CCO:C0000385 ! microtubule organizing center is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: location_of CCO:B0001368 ! CETN3_HUMAN relationship: location_of CCO:B0001408 ! EVI5_HUMAN relationship: location_of CCO:B0001519 ! CCNB1_HUMAN relationship: location_of CCO:B0001731 ! CETN1_HUMAN relationship: location_of CCO:B0001918 ! SAS6_HUMAN relationship: location_of CCO:B0002088 ! Q99773_HUMAN relationship: location_of CCO:B0002099 ! CP250_HUMAN relationship: location_of CCO:B0002114 ! Q9BYG9_HUMAN relationship: location_of CCO:B0002211 ! TBE_HUMAN relationship: location_of CCO:B0010567 ! APC_HUMAN-Phosphoserine1038 relationship: location_of CCO:B0010859 ! BRCA2_HUMAN-Phosphoserine683 relationship: location_of CCO:B0011074 ! CDC27_HUMAN-Phosphothreonine430 relationship: location_of CCO:B0011243 ! CKAP5_HUMAN-Phosphoserine816 relationship: location_of CCO:B0011767 ! ESPL1_HUMAN-Phosphoserine1508 relationship: location_of CCO:B0012609 ! KIFC1_HUMAN-Phosphoserine33 relationship: location_of CCO:B0012680 ! LATS1_HUMAN-Phosphoserine909 relationship: location_of CCO:B0012726 ! M3K11_HUMAN-Phosphoserine740 relationship: location_of CCO:B0013133 ! NDE1_HUMAN-Phosphoserine306 relationship: location_of CCO:B0013855 ! RGC32_HUMAN-Phosphothreonine111 relationship: location_of CCO:B0013954 ! SAC31_HUMAN-Phosphoserine401 relationship: location_of CCO:B0026380 ! JUB_HUMAN-Phosphoserine119 relationship: location_of CCO:B0039949 ! FSD1_HUMAN [Term] id: CCO:C0000384 name: centriole namespace: cellular_component def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] xref: GO:0005814 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001869 ! microtubule organizing center part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: location_of CCO:B0001368 ! CETN3_HUMAN relationship: location_of CCO:B0011319 ! CNTRB_HUMAN-Phosphoserine781 relationship: part_of CCO:C0000383 ! centrosome [Term] id: CCO:C0000385 name: microtubule organizing center namespace: cellular_component def: "A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [ISBN:0815316194] subset: goslim_candida subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: GO:0005815 is_a: CCO:C0001863 ! cytoplasmic part relationship: location_of CCO:B0002099 ! CP250_HUMAN relationship: location_of CCO:B0002148 ! CHM1A_HUMAN relationship: part_of CCO:C0000754 ! microtubule cytoskeleton [Term] id: CCO:C0000386 name: spindle pole body namespace: cellular_component def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568] xref: GO:0005816 is_a: CCO:C0000385 ! microtubule organizing center is_a: CCO:C0001849 ! cytoskeletal part relationship: location_of CCO:B0001731 ! CETN1_HUMAN relationship: part_of CCO:C0000144 ! spindle pole [Term] id: CCO:C0000387 name: aster namespace: cellular_component def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] xref: GO:0005818 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: part_of CCO:C0000388 ! spindle [Term] id: CCO:C0000388 name: spindle namespace: cellular_component def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] xref: GO:0005819 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: location_of CCO:B0001659 ! KIF11_HUMAN relationship: location_of CCO:B0002003 ! SKA2_HUMAN relationship: location_of CCO:B0002032 ! SKA1_HUMAN relationship: location_of CCO:B0002088 ! Q99773_HUMAN relationship: location_of CCO:B0002221 ! FBX5_HUMAN relationship: location_of CCO:B0010926 ! CASL_HUMAN-Phosphotyrosine166 relationship: location_of CCO:B0011074 ! CDC27_HUMAN-Phosphothreonine430 relationship: location_of CCO:B0011147 ! CENPE_HUMAN-Phosphoserine454 relationship: location_of CCO:B0012594 ! KIF23_HUMAN-Phosphoserine682 relationship: location_of CCO:B0012609 ! KIFC1_HUMAN-Phosphoserine33 relationship: location_of CCO:B0012613 ! KNTC1_HUMAN-Phosphoserine2098 relationship: location_of CCO:B0013133 ! NDE1_HUMAN-Phosphoserine306 relationship: location_of CCO:B0013325 ! NUMA1_HUMAN-Phosphoserine2077 relationship: location_of CCO:B0013954 ! SAC31_HUMAN-Phosphoserine401 relationship: location_of CCO:B0014164 ! SPAG5_HUMAN-Phosphoserine249 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: part_of CCO:C0000754 ! microtubule cytoskeleton [Term] id: CCO:C0000389 name: intermediate layer of spindle pole body namespace: cellular_component def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630] xref: GO:0005821 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001869 ! microtubule organizing center part relationship: part_of CCO:C0000386 ! spindle pole body [Term] id: CCO:C0000390 name: inner plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568] xref: GO:0005822 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001869 ! microtubule organizing center part relationship: part_of CCO:C0000386 ! spindle pole body [Term] id: CCO:C0000391 name: central plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568] xref: GO:0005823 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001869 ! microtubule organizing center part relationship: part_of CCO:C0000386 ! spindle pole body [Term] id: CCO:C0000392 name: outer plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568] xref: GO:0005824 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001869 ! microtubule organizing center part relationship: part_of CCO:C0000386 ! spindle pole body [Term] id: CCO:C0000393 name: half bridge of spindle pole body namespace: cellular_component def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568] xref: GO:0005825 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001869 ! microtubule organizing center part relationship: part_of CCO:C0000386 ! spindle pole body [Term] id: CCO:C0000394 name: contractile ring namespace: cellular_component def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194] synonym: "actomyosin ring" RELATED [] synonym: "actomyosin ring (sensu Fungi)" NARROW [] synonym: "CAR" EXACT [] synonym: "constriction ring" RELATED [] synonym: "contractile actomyosin ring" EXACT [] synonym: "contractile ring (sensu Fungi)" NARROW [] synonym: "cytokinetic ring (sensu Fungi)" NARROW [] xref: GO:0005826 xref: GO:0030480 is_a: CCO:C0001404 ! cell division site part is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001867 ! cell cortex part relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0000395 name: polar microtubule namespace: cellular_component def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194] synonym: "pole-to-pole microtubule" EXACT [] xref: GO:0005827 is_a: CCO:C0000436 ! spindle microtubule relationship: part_of CCO:C0000144 ! spindle pole [Term] id: CCO:C0000396 name: kinetochore microtubule namespace: cellular_component def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] synonym: "pole-to-kinetochore microtubule" EXACT [] xref: GO:0005828 is_a: CCO:C0000436 ! spindle microtubule relationship: location_of CCO:B0012613 ! KNTC1_HUMAN-Phosphoserine2098 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 [Term] id: CCO:C0000397 name: cytosol namespace: cellular_component def: "That part of the cytoplasm that does not contain membranous or particulate subcellular components." [ISBN:0198547684] subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: GO:0005829 is_a: CCO:C0001863 ! cytoplasmic part relationship: location_of CCO:B0001353 ! PPP6_HUMAN relationship: location_of CCO:B0001354 ! UBE2C_HUMAN relationship: location_of CCO:B0001458 ! BCL10_HUMAN relationship: location_of CCO:B0001519 ! CCNB1_HUMAN relationship: location_of CCO:B0001523 ! PGDH_HUMAN relationship: location_of CCO:B0001551 ! CCND1_HUMAN relationship: location_of CCO:B0001625 ! PSMD8_HUMAN relationship: location_of CCO:B0001701 ! CCNA1_HUMAN relationship: location_of CCO:B0001737 ! STRN3_HUMAN relationship: location_of CCO:B0001748 ! MD2L1_HUMAN relationship: location_of CCO:B0001759 ! CUL1_HUMAN relationship: location_of CCO:B0002027 ! CUL5_HUMAN relationship: location_of CCO:B0002177 ! APC11_HUMAN relationship: location_of CCO:B0002215 ! APC4_HUMAN relationship: location_of CCO:B0002221 ! FBX5_HUMAN relationship: location_of CCO:B0005634 ! SKP1_HUMAN relationship: location_of CCO:B0006215 ! PSME1_HUMAN relationship: location_of CCO:B0010567 ! APC_HUMAN-Phosphoserine1038 relationship: location_of CCO:B0010997 ! CCNE2_HUMAN-Phosphothreonine392 relationship: location_of CCO:B0011062 ! CDC23_HUMAN-Phosphothreonine559 relationship: location_of CCO:B0011066 ! CDC26_HUMAN-Phosphoserine78 relationship: location_of CCO:B0011074 ! CDC27_HUMAN-Phosphothreonine430 relationship: location_of CCO:B0011087 ! CDC6_HUMAN-Phosphothreonine166 relationship: location_of CCO:B0011105 ! CDK2_HUMAN-Phosphotyrosine19 relationship: location_of CCO:B0011127 ! CDN1B_HUMAN-Phosphoserine140 relationship: location_of CCO:B0012939 ! MK01_HUMAN-Phosphotyrosine187 relationship: location_of CCO:B0012941 ! MK03_HUMAN-N-acetylalanine2 relationship: location_of CCO:B0013453 ! PDCD4_HUMAN-Phosphoserine457 relationship: location_of CCO:B0013617 ! PRS4_HUMAN-Phosphotyrosine439 relationship: location_of CCO:B0013618 ! PSA1_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0013650 ! PTTG1_HUMAN-Phosphoserine165 relationship: location_of CCO:B0013709 ! RAP1A_HUMAN-Cysteine methyl ester181 relationship: location_of CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 relationship: location_of CCO:B0019462 ! UB2D1_HUMAN relationship: location_of CCO:B0021560 ! PSMD3_HUMAN relationship: location_of CCO:B0023606 ! PSDE_HUMAN relationship: location_of CCO:B0030800 ! PSB2_HUMAN relationship: location_of CCO:B0032651 ! PSMD6_HUMAN relationship: location_of CCO:B0034007 ! PSB7_HUMAN relationship: location_of CCO:B0035474 ! PSA5_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0035478 ! PSB1_HUMAN-Phosphotyrosine150 relationship: location_of CCO:B0035935 ! MEN1_HUMAN relationship: location_of CCO:B0039597 ! PRS10_HUMAN-N-acetylalanine2 relationship: location_of CCO:B0041246 ! PRS7_HUMAN relationship: location_of CCO:B0041248 ! UB2E1_HUMAN relationship: location_of CCO:B0041255 ! PSMD5_HUMAN relationship: location_of CCO:B0041324 ! PSA4_HUMAN-Phosphoserine13 relationship: location_of CCO:B0041328 ! PSD10_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0041333 ! PSMD4_HUMAN-Phosphoserine358 relationship: location_of CCO:B0041336 ! PSMD9_HUMAN-Phosphoserine129 [Term] id: CCO:C0000399 name: steroid hormone aporeceptor complex namespace: cellular_component def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981] xref: GO:0005831 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000400 name: chaperonin-containing T-complex namespace: cellular_component def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] synonym: "CCT particle" EXACT [] synonym: "TriC" EXACT [] xref: GO:0005832 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000401 name: hemoglobin complex namespace: cellular_component def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "haemoglobin complex" EXACT [] xref: GO:0005833 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000402 name: heterotrimeric G-protein complex namespace: cellular_component def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] comment: See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'. subset: gosubset_prok synonym: "heterotrimeric G-protein GTPase activity" RELATED [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW [] xref: GO:0005834 is_a: CCO:C0000899 ! extrinsic to plasma membrane is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000403 name: fatty acid synthase complex namespace: cellular_component def: "A multienzyme complex required to convert carbohydrates to fatty acids, specifically acetyl CoA to palmitate." [GOC:sgd_curators, ISBN:0716746840] subset: goslim_pir subset: gosubset_prok synonym: "FAS complex" EXACT [] synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED [] xref: GO:0005835 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000404 name: fatty-acyl-CoA synthase complex namespace: cellular_component def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [BRENDA:2.3.1.86, GOC:mah] comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes. xref: GO:0005836 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000407 name: ribosome namespace: cellular_component def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "ribosomal RNA" RELATED [] xref: GO:0005840 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle [Term] id: CCO:C0000410 name: polysome namespace: cellular_component def: "Several ribosomes bound to one mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir synonym: "polyribosome" EXACT [] xref: GO:0005844 is_a: CCO:C0001019 ! ribonucleoprotein complex relationship: location_of CCO:B0013618 ! PSA1_HUMAN-N-acetylmethionine1 [Term] id: CCO:C0000411 name: mRNA cap complex namespace: cellular_component def: "Any complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jic] xref: GO:0005845 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000412 name: nuclear cap binding complex namespace: cellular_component def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA." [PMID:16043498] synonym: "CBC" RELATED [] synonym: "mRNA cap binding complex" NARROW [] synonym: "snRNA cap binding complex" NARROW [] xref: GO:0005846 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000413 name: mRNA cleavage and polyadenylation specificity factor complex namespace: cellular_component def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727] synonym: "CFII complex" RELATED [] synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] synonym: "CPF complex" NARROW [] synonym: "CPSF complex" NARROW [] xref: GO:0005847 is_a: CCO:C0000415 ! mRNA cleavage factor complex [Term] id: CCO:C0000414 name: mRNA cleavage stimulating factor complex namespace: cellular_component def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856] synonym: "cleavage stimulation factor activity" RELATED [] synonym: "CstF complex" NARROW [] xref: GO:0005848 is_a: CCO:C0000415 ! mRNA cleavage factor complex [Term] id: CCO:C0000415 name: mRNA cleavage factor complex namespace: cellular_component def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856] subset: goslim_pir xref: GO:0005849 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0000416 name: eukaryotic translation initiation factor 2 complex namespace: cellular_component def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940] synonym: "eIF-2" EXACT [] xref: GO:0005850 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000417 name: eukaryotic translation initiation factor 2B complex namespace: cellular_component def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] synonym: "eIF-2B" EXACT [] xref: GO:0005851 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000418 name: eukaryotic translation initiation factor 3 complex namespace: cellular_component def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex." [PMID:15904532] synonym: "eIF-3" EXACT [] synonym: "eIF3" EXACT [] xref: GO:0005852 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000419 name: eukaryotic translation elongation factor 1 complex namespace: cellular_component def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950, UniProtKB:P24534] xref: GO:0005853 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000420 name: nascent polypeptide-associated complex namespace: cellular_component def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] synonym: "NAC" EXACT [] synonym: "NACA" EXACT [] xref: GO:0005854 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000421 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0005856 is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: location_of CCO:B0001401 ! GAS2_HUMAN relationship: location_of CCO:B0001731 ! CETN1_HUMAN relationship: location_of CCO:B0001985 ! GA2L2_HUMAN relationship: location_of CCO:B0002156 ! BIN3_HUMAN relationship: location_of CCO:B0002257 ! CD2AP_HUMAN relationship: location_of CCO:B0010926 ! CASL_HUMAN-Phosphotyrosine166 relationship: location_of CCO:B0011263 ! CLIP1_HUMAN-Phosphoserine200 relationship: location_of CCO:B0011452 ! DCTN1_HUMAN-Phosphoserine541 relationship: location_of CCO:B0013133 ! NDE1_HUMAN-Phosphoserine306 relationship: location_of CCO:B0026380 ! JUB_HUMAN-Phosphoserine119 [Term] id: CCO:C0000422 name: axonemal dynein complex namespace: cellular_component def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which in converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains." [ISBN:0815316194] synonym: "axonemal dynein heavy chain" NARROW [] synonym: "axonemal dynein intermediate chain" NARROW [] synonym: "axonemal dynein intermediate light chain" NARROW [] synonym: "axonemal dynein light chain" NARROW [] xref: GO:0005858 is_a: CCO:C0000995 ! dynein complex is_a: CCO:C0001866 ! axoneme part [Term] id: CCO:C0000423 name: muscle myosin complex namespace: cellular_component def: "A filament of myosin found in a muscle cell of any type." [GOC:mah] xref: GO:0005859 is_a: CCO:C0000789 ! myosin II complex is_a: CCO:C0001868 ! contractile fiber part [Term] id: CCO:C0000424 name: troponin complex namespace: cellular_component def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194] xref: GO:0005861 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0000427 ! striated muscle thin filament [Term] id: CCO:C0000425 name: muscle thin filament tropomyosin namespace: cellular_component def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] xref: GO:0005862 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0000427 ! striated muscle thin filament [Term] id: CCO:C0000426 name: striated muscle thick filament namespace: cellular_component def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194] xref: GO:0005863 is_a: CCO:C0000423 ! muscle myosin complex is_a: CCO:C0001490 ! myosin filament relationship: part_of CCO:C0000933 ! sarcomere [Term] id: CCO:C0000427 name: striated muscle thin filament namespace: cellular_component def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] xref: GO:0005865 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0000753 ! actin cytoskeleton relationship: part_of CCO:C0000933 ! sarcomere [Term] id: CCO:C0000428 name: cytoplasmic dynein complex namespace: cellular_component def: "Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311] synonym: "cytoplasmic dynein heavy chain" NARROW [] synonym: "cytoplasmic dynein intermediate chain" NARROW [] synonym: "cytoplasmic dynein intermediate light chain" NARROW [] synonym: "cytoplasmic dynein light chain" NARROW [] xref: GO:0005868 is_a: CCO:C0000995 ! dynein complex [Term] id: CCO:C0000429 name: dynactin complex namespace: cellular_component def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005869 is_a: CCO:C0000435 ! microtubule associated complex relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0000430 name: actin capping protein of dynactin complex namespace: cellular_component def: "A heterodimer consisting of alpha and a beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, UniProtKB:P14315] xref: GO:0005870 is_a: CCO:C0000542 ! F-actin capping protein complex relationship: part_of CCO:C0000429 ! dynactin complex [Term] id: CCO:C0000431 name: kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] xref: GO:0005871 is_a: CCO:C0000435 ! microtubule associated complex relationship: location_of CCO:B0001659 ! KIF11_HUMAN relationship: location_of CCO:B0012594 ! KIF23_HUMAN-Phosphoserine682 [Term] id: CCO:C0000432 name: minus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah] xref: GO:0005872 is_a: CCO:C0000431 ! kinesin complex [Term] id: CCO:C0000433 name: plus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah] xref: GO:0005873 is_a: CCO:C0000431 ! kinesin complex [Term] id: CCO:C0000434 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] xref: GO:0005874 is_a: CCO:C0001849 ! cytoskeletal part relationship: location_of CCO:B0001659 ! KIF11_HUMAN relationship: location_of CCO:B0002180 ! GTSE1_HUMAN relationship: location_of CCO:B0002211 ! TBE_HUMAN relationship: location_of CCO:B0011147 ! CENPE_HUMAN-Phosphoserine454 relationship: location_of CCO:B0011263 ! CLIP1_HUMAN-Phosphoserine200 relationship: location_of CCO:B0011452 ! DCTN1_HUMAN-Phosphoserine541 relationship: location_of CCO:B0012169 ! HDAC6_HUMAN-Phosphothreonine30 relationship: location_of CCO:B0012594 ! KIF23_HUMAN-Phosphoserine682 relationship: location_of CCO:B0012609 ! KIFC1_HUMAN-Phosphoserine33 relationship: location_of CCO:B0012726 ! M3K11_HUMAN-Phosphoserine740 relationship: location_of CCO:B0013133 ! NDE1_HUMAN-Phosphoserine306 relationship: location_of CCO:B0013810 ! RCC2_HUMAN-Phosphothreonine20 relationship: location_of CCO:B0014164 ! SPAG5_HUMAN-Phosphoserine249 relationship: location_of CCO:B0039949 ! FSD1_HUMAN relationship: part_of CCO:C0000754 ! microtubule cytoskeleton [Term] id: CCO:C0000435 name: microtubule associated complex namespace: cellular_component def: "Any multimeric complex connected to a microtubule." [GOC:jl] xref: GO:0005875 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001849 ! cytoskeletal part relationship: location_of CCO:B0001659 ! KIF11_HUMAN relationship: location_of CCO:B0011147 ! CENPE_HUMAN-Phosphoserine454 relationship: location_of CCO:B0012594 ! KIF23_HUMAN-Phosphoserine682 relationship: location_of CCO:B0012609 ! KIFC1_HUMAN-Phosphoserine33 relationship: part_of CCO:C0000754 ! microtubule cytoskeleton [Term] id: CCO:C0000436 name: spindle microtubule namespace: cellular_component def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] xref: GO:0005876 is_a: CCO:C0000434 ! microtubule relationship: location_of CCO:B0001659 ! KIF11_HUMAN relationship: location_of CCO:B0011074 ! CDC27_HUMAN-Phosphothreonine430 relationship: location_of CCO:B0013325 ! NUMA1_HUMAN-Phosphoserine2077 relationship: part_of CCO:C0000388 ! spindle [Term] id: CCO:C0000437 name: axonemal microtubule namespace: cellular_component def: "A microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [ISBN:0815316194] xref: GO:0005879 is_a: CCO:C0000434 ! microtubule is_a: CCO:C0001866 ! axoneme part [Term] id: CCO:C0000438 name: nuclear microtubule namespace: cellular_component def: "Any microtubule in the nucleus of a cell." [GOC:mah] xref: GO:0005880 is_a: CCO:C0000434 ! microtubule is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000439 name: cytoplasmic microtubule namespace: cellular_component def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] synonym: "non-spindle-associated astral microtubule" NARROW [] xref: GO:0005881 is_a: CCO:C0000434 ! microtubule relationship: location_of CCO:B0002180 ! GTSE1_HUMAN [Term] id: CCO:C0000440 name: intermediate filament namespace: cellular_component def: "A distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: keratin filaments of mammalian epithelial cells; desmin filaments found in cells of muscles of all types; vimentin filaments found in mesenchymal cells; neurofilaments of neurons; and glial filaments found in all types of glial cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "intermediate filament associated protein" RELATED [] synonym: "type I intermediate filament associated protein" RELATED [] synonym: "type II intermediate filament associated protein" RELATED [] xref: GO:0005882 is_a: CCO:C0001849 ! cytoskeletal part relationship: location_of CCO:B0011263 ! CLIP1_HUMAN-Phosphoserine200 relationship: part_of CCO:C0001888 ! intermediate filament cytoskeleton [Term] id: CCO:C0000441 name: neurofilament namespace: cellular_component def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363, ISBN:0815316194] synonym: "type IV intermediate filament" EXACT [] xref: GO:0005883 is_a: CCO:C0000440 ! intermediate filament relationship: part_of CCO:C0002030 ! neurofilament cytoskeleton [Term] id: CCO:C0000442 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10666339] synonym: "microfilament" BROAD [] xref: GO:0005884 is_a: CCO:C0001849 ! cytoskeletal part relationship: location_of CCO:B0001401 ! GAS2_HUMAN relationship: location_of CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0000443 name: Arp2/3 protein complex namespace: cellular_component def: "A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments." [GOC:jl, PMID:12479800] xref: GO:0005885 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0000444 name: plasma membrane namespace: cellular_component def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasmalemma" EXACT [] xref: GO:0005886 is_a: CCO:C0000766 ! membrane relationship: location_of CCO:B0001453 ! DIRA3_HUMAN relationship: location_of CCO:B0001470 ! EGF_HUMAN relationship: location_of CCO:B0001672 ! GAS1_HUMAN relationship: location_of CCO:B0001758 ! ULA1_HUMAN relationship: location_of CCO:B0002064 ! GML_HUMAN relationship: location_of CCO:B0002079 ! Q99648_HUMAN relationship: location_of CCO:B0002110 ! CADM1_HUMAN relationship: location_of CCO:B0002150 ! PAR6A_HUMAN relationship: location_of CCO:B0002175 ! NSMA2_HUMAN relationship: location_of CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 relationship: location_of CCO:B0012757 ! MADD_HUMAN-Phosphoserine1059 relationship: location_of CCO:B0013046 ! MTUS1_HUMAN-Phosphoserine1264 relationship: location_of CCO:B0013709 ! RAP1A_HUMAN-Cysteine methyl ester181 relationship: location_of CCO:B0026380 ! JUB_HUMAN-Phosphoserine119 relationship: location_of CCO:B0031342 ! MYO16_HUMAN-Phosphotyrosine1432 relationship: location_of CCO:B0041194 ! SEPT5_HUMAN-Phosphoserine225 [Term] id: CCO:C0000445 name: integral to plasma membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] subset: gosubset_prok xref: GO:0005887 is_a: CCO:C0000767 ! integral to membrane is_a: CCO:C0001150 ! intrinsic to plasma membrane relationship: location_of CCO:B0001362 ! EREG_HUMAN relationship: location_of CCO:B0035985 ! ACVR1_HUMAN-Phosphoserine501 relationship: location_of CCO:B0035997 ! DCC_HUMAN-Phosphoserine1073 [Term] id: CCO:C0000446 name: hydrogen:potassium-exchanging ATPase complex namespace: cellular_component def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of Na+ and K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431] synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT [] synonym: "proton pump" BROAD [] xref: GO:0005889 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000447 name: sodium:potassium-exchanging ATPase complex namespace: cellular_component def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "sodium pump" BROAD [] synonym: "sodium/potassium-exchanging ATPase complex" EXACT [] xref: GO:0005890 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000448 name: voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah] subset: goslim_pir synonym: "voltage gated calcium channel complex" EXACT [] synonym: "voltage-dependent calcium channel complex" EXACT [] synonym: "voltage-sensitive calcium channel complex" EXACT [] xref: GO:0005891 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000449 name: nicotinic acetylcholine-gated receptor-channel complex namespace: cellular_component def: "A protein complex that acts as an acetylcholine receptor, and forms a transmembrane channel through which ions may pass in response to ligand binding. The complex is a homo- or heteropentamer of subunits that are members of a neurotransmitter receptor superfamily." [GOC:mah, PMID:12381728, PMID:15579462] synonym: "nicotinic acetylcholine receptor" BROAD [] xref: GO:0005892 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000450 name: interleukin-2 receptor complex namespace: cellular_component def: "Complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078] xref: GO:0005893 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000451 name: interleukin-3 receptor complex namespace: cellular_component def: "Complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579] xref: GO:0005894 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000452 name: interleukin-5 receptor complex namespace: cellular_component def: "Complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579] xref: GO:0005895 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000453 name: interleukin-6 receptor complex namespace: cellular_component def: "A hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235] xref: GO:0005896 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000454 name: interleukin-9 receptor complex namespace: cellular_component def: "Complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536] xref: GO:0005897 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000455 name: interleukin-13 receptor complex namespace: cellular_component def: "A complex that binds interleukin-13; consists of two chains, interleukin-4 receptor alpha chain and interleukin-4 receptor alpha chain." [UniProtKB:P78552] xref: GO:0005898 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000456 name: insulin receptor complex namespace: cellular_component def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005899 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000457 name: oncostatin-M receptor complex namespace: cellular_component def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038] xref: GO:0005900 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000458 name: caveola namespace: cellular_component def: "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the cell membrane formed during pinocytosis, that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Such caveolae may be pinched off to form free vesicles within the cytoplasm." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "caveolae" EXACT [] synonym: "caveolar membrane" RELATED [] xref: GO:0005901 xref: GO:0016599 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0002123 ! membrane raft [Term] id: CCO:C0000459 name: microvillus namespace: cellular_component def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194] subset: goslim_pir xref: GO:0005902 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0000460 name: brush border namespace: cellular_component def: "Dense covering of microvilli on the apical surface of epithelial cells in the intestine and kidney; the microvilli aid absorption by increasing the surface area of the cell." [ISBN:0815316194] subset: goslim_pir xref: GO:0005903 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0000461 name: plasma membrane lipid bilayer namespace: cellular_component def: "The phospholipid membrane surrounding a cell that separates the cell from its external environment, excluding intergral and associated proteins." [GOC:go_curators] xref: GO:0005904 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000462 name: coated pit namespace: cellular_component def: "An invagination of the cell membrane of many eukaryotic cells, concerned in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane. During endocytosis it is converted into a coated vesicle. The coat is of clathrin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005905 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000463 name: intercellular junction namespace: cellular_component def: "A specialized region of connection between two cells including but not limited to gap junctions, desmosomes, and tight junctions, but excluding direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb] synonym: "cell-cell junction" EXACT [] xref: GO:0005911 is_a: CCO:C0000936 ! cell junction relationship: location_of CCO:B0002110 ! CADM1_HUMAN relationship: location_of CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 [Term] id: CCO:C0000464 name: adherens junction namespace: cellular_component def: "A cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005912 is_a: CCO:C0000936 ! cell junction [Term] id: CCO:C0000465 name: cell-cell adherens junction namespace: cellular_component def: "An adherens junction which connects two cells to each other." [GOC:hb] xref: GO:0005913 is_a: CCO:C0000463 ! intercellular junction is_a: CCO:C0000464 ! adherens junction [Term] id: CCO:C0000466 name: spot adherens junction namespace: cellular_component def: "A small junction assombled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298] synonym: "dense plaque" BROAD [] synonym: "punctum adherens" EXACT [] xref: GO:0005914 is_a: CCO:C0000465 ! cell-cell adherens junction [Term] id: CCO:C0000467 name: zonula adherens namespace: cellular_component def: "Cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] synonym: "belt desmosome" EXACT [] synonym: "intermediate junction" EXACT [] xref: GO:0005915 is_a: CCO:C0000465 ! cell-cell adherens junction relationship: part_of CCO:C0001769 ! apical junction complex [Term] id: CCO:C0000468 name: fascia adherens namespace: cellular_component def: "An electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains gap junctions and desmosomes. Most of the disc is formed of a convoluted fascia adherens type of junction into which the actin filaments of the terminal sarcomeres insert (or in the case of muscle cells, myofibrils), desmosomes are also present. The lateral portion of the stepped disc contains gap junctions that couple the cells electrically and thus coordinate the contraction." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk] xref: GO:0005916 is_a: CCO:C0000465 ! cell-cell adherens junction relationship: part_of CCO:C0000743 ! intercalated disc [Term] id: CCO:C0000469 name: nephrocyte junction namespace: cellular_component def: "A tissue-specific adherens junction found in kidney cells." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm] xref: GO:0005917 is_a: CCO:C0000465 ! cell-cell adherens junction [Term] id: CCO:C0000470 name: septate junction namespace: cellular_component def: "Invertebrate-specific cell-cell junctions which form a band around the apical borders of epithelial cells and attach to actin filaments." [ISBN:0815316208] synonym: "septate desmosome" RELATED [] xref: GO:0005918 is_a: CCO:C0000465 ! cell-cell adherens junction relationship: part_of CCO:C0001769 ! apical junction complex [Term] id: CCO:C0000471 name: pleated septate junction namespace: cellular_component def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] synonym: "pleated desmosome" RELATED [] xref: GO:0005919 is_a: CCO:C0000470 ! septate junction [Term] id: CCO:C0000472 name: smooth septate junction namespace: cellular_component def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] synonym: "zonula continua" EXACT [] xref: GO:0005920 is_a: CCO:C0000470 ! septate junction [Term] id: CCO:C0000473 name: gap junction namespace: cellular_component def: "Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon. This gap junction allows passage of small molecules and electric current. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junction." [GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "communicating junction" EXACT [] synonym: "macula communicans" EXACT [] synonym: "zonula communicans" EXACT [] xref: GO:0005921 is_a: CCO:C0000463 ! intercellular junction relationship: part_of CCO:C0000743 ! intercalated disc [Term] id: CCO:C0000474 name: connexon complex namespace: cellular_component def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276] xref: GO:0005922 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000473 ! gap junction [Term] id: CCO:C0000475 name: tight junction namespace: cellular_component def: "A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "zonula occludens" EXACT [] xref: GO:0005923 is_a: CCO:C0000463 ! intercellular junction relationship: location_of CCO:B0002112 ! PAR6G_HUMAN relationship: location_of CCO:B0002150 ! PAR6A_HUMAN relationship: part_of CCO:C0001769 ! apical junction complex [Term] id: CCO:C0000476 name: cell-substrate adherens junction namespace: cellular_component def: "An adherens junction which connects a cell to the extracellular matrix." [GOC:hb] synonym: "hemi-adherens junction" RELATED [] xref: GO:0005924 is_a: CCO:C0000464 ! adherens junction is_a: CCO:C0002136 ! cell-substrate junction [Term] id: CCO:C0000477 name: focal adhesion namespace: cellular_component def: "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that are points of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] synonym: "focal contact" EXACT [] synonym: "hemi-adherens junction" EXACT [] xref: GO:0005925 xref: GO:0008357 is_a: CCO:C0000476 ! cell-substrate adherens junction [Term] id: CCO:C0000478 name: connecting hemi-adherens junction namespace: cellular_component def: "A hemiadherens junction (HAJ) that forms one of a pair of HAJs in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects)." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm] xref: GO:0005926 is_a: CCO:C0000476 ! cell-substrate adherens junction [Term] id: CCO:C0000479 name: muscle tendon junction namespace: cellular_component def: "Terminal anchorage site of skeletal muscle cells to tendons; a specialised type of contact between the cell and the extracellular matrix in skeletal muscle." [GOC:mtg_muscle, PMID:12842007] synonym: "myotendinous junction" EXACT [] xref: GO:0005927 is_a: CCO:C0000476 ! cell-substrate adherens junction [Term] id: CCO:C0000480 name: apical hemi-adherens junction namespace: cellular_component def: "An adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298] synonym: "apical dense plaque" EXACT [] xref: GO:0005928 is_a: CCO:C0000476 ! cell-substrate adherens junction [Term] id: CCO:C0000481 name: cilium namespace: cellular_component def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kva, ISBN:0198547684] subset: goslim_generic subset: goslim_pir xref: GO:0005929 is_a: CCO:C0001706 ! cell projection relationship: location_of CCO:B0002099 ! CP250_HUMAN [Term] id: CCO:C0000482 name: axoneme namespace: cellular_component def: "The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [ISBN:0198547684] xref: GO:0005930 is_a: CCO:C0001865 ! intracellular organelle part is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0000483 name: nexin complex namespace: cellular_component def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005931 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001866 ! axoneme part [Term] id: CCO:C0000484 name: basal body namespace: cellular_component def: "A short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum that is similar in structure to a centriole. The basal body serves as a nucleation site for axoneme growth." [GOC:clt] xref: GO:0005932 is_a: CCO:C0000385 ! microtubule organizing center is_a: CCO:C0001881 ! cell projection part [Term] id: CCO:C0000485 name: cellular bud namespace: cellular_component def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators] subset: goslim_candida subset: goslim_pir subset: goslim_yeast xref: GO:0005933 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000486 name: cellular bud tip namespace: cellular_component def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah] xref: GO:0005934 is_a: CCO:C0001007 ! site of polarized growth relationship: part_of CCO:C0000485 ! cellular bud [Term] id: CCO:C0000487 name: cellular bud neck namespace: cellular_component def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah] xref: GO:0005935 is_a: CCO:C0001007 ! site of polarized growth relationship: part_of CCO:C0000485 ! cellular bud [Term] id: CCO:C0000488 name: mating projection namespace: cellular_component def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc] subset: goslim_pir synonym: "conjugation tube" NARROW [] synonym: "shmoo" NARROW [] xref: GO:0005937 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0000489 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "peripheral cytoplasm" RELATED [] xref: GO:0005938 is_a: CCO:C0001863 ! cytoplasmic part relationship: location_of CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 relationship: location_of CCO:B0036017 ! MYH10_HUMAN-Phosphothreonine1376 [Term] id: CCO:C0000490 name: septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244] synonym: "septin ring (sensu Fungi)" NARROW [] xref: GO:0005940 xref: GO:0030481 is_a: CCO:C0001405 ! septin cytoskeleton is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001867 ! cell cortex part [Term] id: CCO:C0000492 name: phosphoinositide 3-kinase complex namespace: cellular_component def: "A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K)." [GOC:bf] subset: goslim_pir synonym: "1-phosphatidylinositol 3-kinase complex" EXACT [] synonym: "PI3K complex" EXACT [] xref: GO:0005942 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000495 name: 6-phosphofructokinase complex namespace: cellular_component def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric and allosteric homotetrameric forms are known." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005945 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000496 name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) namespace: cellular_component def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904] comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'. synonym: "trehalose-6-phosphate synthase complex" EXACT [] synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT [] xref: GO:0005946 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000497 name: mitochondrial alpha-ketoglutarate dehydrogenase complex namespace: cellular_component def: "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] synonym: "alpha-ketoglutarate dehydrogenase complex (sensu Eukaryota)" EXACT [] xref: GO:0005947 is_a: CCO:C0000941 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: CCO:C0001904 ! alpha-ketoglutarate dehydrogenase complex [Term] id: CCO:C0000498 name: acetolactate synthase complex namespace: cellular_component def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, UniProt:P37252] comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. subset: gosubset_prok synonym: "acetohydroxyacid synthase complex" EXACT [] xref: GO:0005948 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000499 name: anthranilate synthase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, UniProtKB:P09785] xref: GO:0005950 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000500 name: carbamoyl-phosphate synthase complex namespace: cellular_component def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia moiety cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695] comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. subset: gosubset_prok synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW [] synonym: "carbamoyl phosphate synthase complex" EXACT [] synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW [] xref: GO:0005951 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000501 name: cAMP-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "3',5' cAMP-dependent protein kinase complex" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT [] synonym: "cyclic AMP-dependent protein kinase complex" EXACT [] synonym: "PKA" RELATED [] xref: GO:0005952 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000502 name: CAAX-protein geranylgeranyltransferase complex namespace: cellular_component def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874, UniProtKB:P53609] xref: GO:0005953 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000503 name: calcium- and calmodulin-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17, UniProtKB:Q9UQM7] synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT [] synonym: "CAMK2" EXACT [] synonym: "CaMKII" RELATED [] xref: GO:0005954 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000504 name: calcineurin complex namespace: cellular_component def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951] synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW [] synonym: "protein phosphatase type 2B complex" EXACT [] xref: GO:0005955 is_a: CCO:C0000541 ! protein serine/threonine phosphatase complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000505 name: protein kinase CK2 complex namespace: cellular_component def: "Complex that possesses casein kinase activity, found in nearly every subcellular compartment. Protein kinase CK2 complexes are usually tetramers of two alpha and two beta subunits, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. One function possessed by this complex is represented by the molecular function term 'casein kinase II ; GO:0004682'. synonym: "casein kinase II complex" EXACT [] xref: GO:0005956 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000506 name: DNA-dependent protein kinase complex namespace: cellular_component def: "A large protein complex which is involved in the repair of DNA double-strand breaks and V(D)J recombination events. In mammals, it consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer, Ku, the nuclear phosphoprotein XRCC4 and DNA ligase IV." [GOC:jl, PMID:10854421, PMID:12235392] synonym: "DNA-dependent protein kinase, DNA-end-binding complex" NARROW [] synonym: "DNA-PK complex" EXACT [] xref: GO:0005958 xref: GO:0005959 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000507 name: glycine cleavage complex namespace: cellular_component def: "A multienzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase." [MetaCyc:GCVMULTI-CPLX] subset: goslim_pir subset: gosubset_prok synonym: "glycine cleavage system" EXACT [] synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED [] synonym: "glycine synthase complex" EXACT [] xref: GO:0005960 xref: GO:0005961 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000509 name: mitochondrial isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'. synonym: "isocitrate dehydrogenase complex (NAD+) (sensu Eukaryota)" EXACT [] xref: GO:0005962 is_a: CCO:C0000941 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: CCO:C0001906 ! isocitrate dehydrogenase complex (NAD+) [Term] id: CCO:C0000510 name: magnesium-dependent protein serine/threonine phosphatase complex namespace: cellular_component def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [EC:3.1.3.16] xref: GO:0005963 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000511 name: phosphorylase kinase complex namespace: cellular_component def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19] xref: GO:0005964 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000512 name: protein farnesyltransferase complex namespace: cellular_component def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah] xref: GO:0005965 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000514 name: mitochondrial pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. synonym: "pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)" EXACT [] synonym: "pyruvate dehydrogenase complex (sensu Eukaryota)" EXACT [] xref: GO:0005967 is_a: CCO:C0001848 ! mitochondrial part is_a: CCO:C0001917 ! pyruvate dehydrogenase complex relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000515 name: Rab-protein geranylgeranyltransferase complex namespace: cellular_component def: "A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl moiety from geranylgeranyl pyrophosphate to a Rab protein." [GOC:jl, PMID:11886217, UniProtKB:Q08602] synonym: "GGTase-II complex" EXACT [] synonym: "Rab geranylgeranyltransferase complex" EXACT [] synonym: "RAB-protein geranylgeranyltransferase complex" EXACT [] synonym: "RabGGTase complex" EXACT [] xref: GO:0005968 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000518 name: ribonucleoside-diphosphate reductase complex namespace: cellular_component def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin." [BRENDA:1.17.4.1] subset: gosubset_prok xref: GO:0005971 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000519 name: lamina lucida namespace: cellular_component def: "The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194] xref: GO:0008002 is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000228 ! basal lamina [Term] id: CCO:C0000520 name: lamina densa namespace: cellular_component def: "The electron-dense layer of the basal lamina; lies just below the lamina lucida." [ISBN:0815316194] xref: GO:0008003 is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000228 ! basal lamina [Term] id: CCO:C0000521 name: lamina reticularis namespace: cellular_component def: "A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194] xref: GO:0008004 is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000228 ! basal lamina [Term] id: CCO:C0000522 name: synaptic vesicle namespace: cellular_component def: "Secretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] xref: GO:0008021 is_a: CCO:C0000981 ! clathrin-coated vesicle relationship: location_of CCO:B0002079 ! Q99648_HUMAN relationship: location_of CCO:B0041194 ! SEPT5_HUMAN-Phosphoserine225 [Term] id: CCO:C0000523 name: transcription elongation factor complex namespace: cellular_component def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] subset: goslim_pir xref: GO:0008023 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0000524 name: transcription elongation factor complex b namespace: cellular_component def: "A complex of cyclin T and a cyclin-dependent protein kinase, catalyst, that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme." [UniProtKB:O60563] comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. xref: GO:0008024 is_a: CCO:C0000523 ! transcription elongation factor complex [Term] id: CCO:C0000525 name: ferritin complex namespace: cellular_component def: "A iron-storing protein complex, which in humans has 24 subunits. There are two different ferritin subunits, the L (light) chain and H (heavy) chain." [GOC:jl, UniProtKB:P02792] xref: GO:0008043 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000526 name: guanylate cyclase complex, soluble namespace: cellular_component def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah] comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'. xref: GO:0008074 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000527 name: voltage-gated potassium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] subset: gosubset_prok synonym: "voltage gated potassium channel complex" EXACT [] synonym: "voltage-dependent potassium channel complex" EXACT [] synonym: "voltage-sensitive potassium channel complex" EXACT [] xref: GO:0008076 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: location_of CCO:B0001904 ! KCD11_HUMAN relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000528 name: light-activated voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679] synonym: "light-activated voltage gated calcium channel complex" EXACT [] synonym: "light-activated voltage-dependent calcium channel complex" EXACT [] synonym: "light-activated voltage-sensitive calcium channel complex" EXACT [] xref: GO:0008087 is_a: CCO:C0000448 ! voltage-gated calcium channel complex [Term] id: CCO:C0000529 name: spectrin namespace: cellular_component def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [http://cancerweb.ncl.ac.uk/] xref: GO:0008091 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001867 ! cell cortex part relationship: part_of CCO:C0001056 ! cortical actin cytoskeleton [Term] id: CCO:C0000530 name: signalosome namespace: cellular_component def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] synonym: "COP9 complex" NARROW [] synonym: "CSN" EXACT [] xref: GO:0008180 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000531 name: ecdysone receptor holocomplex namespace: cellular_component def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] xref: GO:0008230 is_a: CCO:C0000272 ! transcription factor complex is_a: CCO:C0001751 ! receptor complex [Term] id: CCO:C0000532 name: repressor ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333] synonym: "repressor ecdysone receptor holocomplex" RELATED [] xref: GO:0008231 is_a: CCO:C0000531 ! ecdysone receptor holocomplex [Term] id: CCO:C0000533 name: activator ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333] synonym: "activator ecdysone receptor holocomplex" RELATED [] xref: GO:0008232 is_a: CCO:C0000531 ! ecdysone receptor holocomplex [Term] id: CCO:C0000534 name: 2-acetyl-1-alkylglycerophosphocholine esterase complex namespace: cellular_component def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206, UniProtKB:Q28017] comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'. subset: gosubset_prok synonym: "1-alkyl-2-acetylglycerophosphocholine esterase complex" EXACT [] synonym: "platelet-activating factor acetylhydrolase complex" EXACT [] xref: GO:0008247 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000535 name: oligosaccharyl transferase complex namespace: cellular_component def: "A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits, at least in yeast." [ISBN:0879695595] synonym: "OST complex" EXACT [] xref: GO:0008250 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0000536 name: gamma-tubulin ring complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075] synonym: "gammaTuRC" EXACT [] xref: GO:0008274 is_a: CCO:C0000150 ! gamma-tubulin large complex relationship: location_of CCO:B0010848 ! BRCA1_HUMAN-Phosphoserine1330 [Term] id: CCO:C0000537 name: gamma-tubulin small complex namespace: cellular_component def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075] synonym: "gammaTuSC" EXACT [] xref: GO:0008275 is_a: CCO:C0000149 ! gamma-tubulin complex [Term] id: CCO:C0000538 name: cohesin complex namespace: cellular_component def: "A protein complex required for sister chromatid cohesion in eukaryotes." [PMID:9887095] subset: goslim_pir synonym: "14S cohesin" NARROW [] synonym: "SMC complex" RELATED [] xref: GO:0008278 xref: GO:0008279 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: location_of CCO:B0011098 ! CDCA5_HUMAN-Phosphothreonine48 [Term] id: CCO:C0000539 name: cohesin core heterodimer namespace: cellular_component def: "The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes." [GOC:jl] synonym: "9S cohesin" NARROW [] synonym: "Smc1-Smc3 complex" NARROW [] xref: GO:0008280 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000538 ! cohesin complex [Term] id: CCO:C0000540 name: ATP-sensitive potassium channel complex namespace: cellular_component def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.2 subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SUR1 subunit stimulates channel activity." [PMID:16308567, PMID:16956886] xref: GO:0008282 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000541 name: protein serine/threonine phosphatase complex namespace: cellular_component def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] subset: goslim_pir subset: gosubset_prok xref: GO:0008287 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part relationship: location_of CCO:B0001372 ! PPM1D_HUMAN relationship: location_of CCO:B0013606 ! PPM1G_HUMAN-Phosphoserine527 [Term] id: CCO:C0000542 name: F-actin capping protein complex namespace: cellular_component def: "A heterodimer consisting of alpha and a beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560] subset: goslim_pir xref: GO:0008290 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0000543 name: caspase complex namespace: cellular_component def: "A cytosolic endopeptidase with specificity for the hydrolysis of aspartyl bonds. Caspases are involved in apoptosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0008303 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000544 name: integrin complex namespace: cellular_component def: "Any member of a family of heterodimeric transmembrane receptors for cell-adhesion molecules. The alpha and beta subunits are noncovalently bonded." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "laminin receptor protein" RELATED [] xref: GO:0008305 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000545 name: ionotropic glutamate receptor complex namespace: cellular_component def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] xref: GO:0008328 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000546 name: katanin complex namespace: cellular_component def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766] comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'. xref: GO:0008352 is_a: CCO:C0000435 ! microtubule associated complex is_a: CCO:C0001869 ! microtubule organizing center part relationship: part_of CCO:C0000383 ! centrosome [Term] id: CCO:C0000547 name: IkappaB kinase complex namespace: cellular_component def: "A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role." [GOC:ma] synonym: "IKK complex" EXACT [] xref: GO:0008385 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part relationship: location_of CCO:B0002228 ! ASC_HUMAN [Term] id: CCO:C0000548 name: proteasome activator complex namespace: cellular_component def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb] synonym: "PA28" NARROW [] xref: GO:0008537 is_a: CCO:C0001750 ! protein complex relationship: location_of CCO:B0006215 ! PSME1_HUMAN relationship: part_of CCO:C0002086 ! proteasome accessory complex [Term] id: CCO:C0000551 name: epsilon DNA polymerase complex namespace: cellular_component def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046] xref: GO:0008622 is_a: CCO:C0001651 ! DNA polymerase complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000003 ! nucleotide-excision repair complex relationship: part_of CCO:C0001798 ! nuclear replisome [Term] id: CCO:C0000552 name: chromatin accessibility complex namespace: cellular_component def: "A multisubunit complex that uses ATP to increase the general accessibility of DNA in chromatin. Unlike other known chromatin remodeling complexes, CHRAC can also function during chromatin assembly; it uses ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing." [GOC:bf, PMID:9252192] synonym: "CHRAC" EXACT [] synonym: "ISW2 complex" NARROW [] xref: GO:0008623 xref: GO:0016588 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0000553 name: peptidoglycan-based cell wall namespace: cellular_component def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan, a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids; also called murein. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mlg, ISBN:0815108893] subset: gosubset_prok synonym: "cell wall (sensu Bacteria)" EXACT [] synonym: "envelope (sensu Bacteria)" BROAD [] synonym: "murein sacculus" RELATED [] synonym: "peptidoglycan" NARROW [] xref: GO:0009274 is_a: CCO:C0000239 ! cell wall [Term] id: CCO:C0000557 name: cell outer membrane namespace: cellular_component def: "A lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:mtg_sensu, ISBN:0135712254] subset: gosubset_prok synonym: "outer membrane (sensu Gram-negative Bacteria)" EXACT [] synonym: "outer membrane (sensu Proteobacteria)" EXACT [] synonym: "outer membrane of cell" EXACT [] xref: GO:0009279 is_a: CCO:C0000898 ! outer membrane is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0001000 ! cell envelope [Term] id: CCO:C0000561 name: flagellin-based flagellum namespace: cellular_component def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:jh2, GOC:mtg_sensu, PMID:7787060] subset: gosubset_prok synonym: "flagellum (sensu Bacteria)" EXACT [] xref: GO:0009288 is_a: CCO:C0000896 ! flagellum [Term] id: CCO:C0000562 name: fimbrium namespace: cellular_component def: "A proteinaceous hair-like appendage on the surface of bacteria; range from 2-8 nm in diameter." [ISBN:0598034692] subset: goslim_pir subset: gosubset_prok synonym: "fimbria" BROAD [] synonym: "fimbriae" EXACT [] synonym: "pilus" BROAD [] xref: GO:0009289 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0000563 name: nucleoid namespace: cellular_component def: "The region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined." [GOC:ma, ISBN:3540076689] subset: gosubset_prok xref: GO:0009295 is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000564 name: 3-isopropylmalate dehydratase complex namespace: cellular_component def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, UniProtKB:Q8TW31] comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'. subset: gosubset_prok synonym: "isopropylmalate isomerase complex" EXACT [] xref: GO:0009316 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000565 name: acetyl-CoA carboxylase complex namespace: cellular_component def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, UniProtKB:P24182] subset: goslim_pir subset: gosubset_prok synonym: "ACCase complex" EXACT [] xref: GO:0009317 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000566 name: exodeoxyribonuclease VII complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6] subset: gosubset_prok xref: GO:0009318 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000567 name: cytochrome o ubiquinol oxidase complex namespace: cellular_component def: "A bacterial heterooctameric enzyme composed of two A chains, two B chains, two C chains and two D chains. Possesses cytochrome o ubiquinol oxidase activity." [GOC:jl, UniProtKB:P0ABJ3] comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'. subset: gosubset_prok xref: GO:0009319 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0000767 ! integral to membrane [Term] id: CCO:C0000568 name: phosphoribosylaminoimidazole carboxylase complex namespace: cellular_component def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah] comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'. subset: gosubset_prok xref: GO:0009320 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000569 name: alkyl hydroperoxide reductase complex namespace: cellular_component def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [BRENDA:1.11.1.15, GOC:jl, UniProtKB:P0A0B5] comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. xref: GO:0009321 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000570 name: trimethylamine-N-oxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [EC:1.6.6.9] subset: gosubset_prok xref: GO:0009322 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000571 name: ribosomal-protein-alanine N-acetyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128] xref: GO:0009323 is_a: CCO:C0001169 ! protein acetyltransferase complex [Term] id: CCO:C0000572 name: D-amino-acid dehydrogenase complex namespace: cellular_component def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah] comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'. subset: gosubset_prok xref: GO:0009324 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000573 name: nitrate reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4] subset: gosubset_prok xref: GO:0009325 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000574 name: formate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [EC:1.2.1.2] subset: gosubset_prok xref: GO:0009326 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000575 name: NAD(P)+ transhydrogenase complex (AB-specific) namespace: cellular_component def: "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [BRENDA:1.6.1.2, GOC:mah] xref: GO:0009327 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000576 name: phenylalanine-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] subset: gosubset_prok xref: GO:0009328 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000577 name: acetate CoA-transferase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, UniProtKB:P08193] xref: GO:0009329 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000565 ! acetyl-CoA carboxylase complex [Term] id: CCO:C0000578 name: DNA topoisomerase complex (ATP-hydrolyzing) namespace: cellular_component def: "Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] comment: See also the molecular function term 'DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918'. subset: gosubset_prok xref: GO:0009330 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000579 name: glycerol-3-phosphate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.99.5] subset: gosubset_prok xref: GO:0009331 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000580 name: glutamate-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17] xref: GO:0009332 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000581 name: cysteine synthase complex namespace: cellular_component def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX] xref: GO:0009333 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000582 name: 3-phenylpropionate dioxygenase complex namespace: cellular_component def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, UniProtKB:P77650] comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'. xref: GO:0009334 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000583 name: sulfate adenylyltransferase complex (ATP) namespace: cellular_component def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4] synonym: "sulphate adenylyltransferase complex (ATP)" EXACT [] xref: GO:0009336 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000584 name: sulfite reductase complex (NADPH) namespace: cellular_component def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of hydrogen sulfide to sulfide." [BRENDA:1.8.1.2, GOC:jl] comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'. subset: gosubset_prok synonym: "sulphite reductase complex (NADPH)" EXACT [] xref: GO:0009337 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000585 name: exodeoxyribonuclease V complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5] subset: gosubset_prok xref: GO:0009338 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000586 name: glycolate oxidase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15] subset: gosubset_prok xref: GO:0009339 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000587 name: DNA topoisomerase IV complex namespace: cellular_component def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, PARC and PARE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, UniProtKB:Q45066] subset: gosubset_prok xref: GO:0009340 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000588 name: beta-galactosidase complex namespace: cellular_component def: "A multimeric enzyme complex that in E. coli is an heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23, UniProtKB:P06864] subset: gosubset_prok xref: GO:0009341 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000589 name: glutamate synthase complex (NADPH) namespace: cellular_component def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah] subset: gosubset_prok xref: GO:0009342 is_a: CCO:C0001114 ! glutamate synthase complex [Term] id: CCO:C0000590 name: biotin carboxylase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14] subset: gosubset_prok xref: GO:0009343 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000565 ! acetyl-CoA carboxylase complex [Term] id: CCO:C0000591 name: nitrite reductase complex [NAD(P)H] namespace: cellular_component def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah] comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'. xref: GO:0009344 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000592 name: glycine-tRNA ligase complex namespace: cellular_component def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, UniProtKB:Q10039, UniProtKB:Q8YVJ2] subset: gosubset_prok synonym: "glycine-tRNA synthetase complex" EXACT [] xref: GO:0009345 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000593 name: citrate lyase complex namespace: cellular_component def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX] subset: gosubset_prok xref: GO:0009346 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000594 name: aspartate carbamoyltransferase complex namespace: cellular_component def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693] comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. subset: gosubset_prok xref: GO:0009347 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000595 name: ornithine carbamoyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a carbamoyl to ornithine, forming citrulline." [EC:2.1.3.3] subset: gosubset_prok xref: GO:0009348 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000596 name: riboflavin synthase complex namespace: cellular_component def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9] subset: gosubset_prok xref: GO:0009349 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000597 name: ethanolamine ammonia-lyase complex namespace: cellular_component def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7] xref: GO:0009350 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000598 name: mitochondrial oxoglutarate dehydrogenase complex namespace: cellular_component def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix." [GOC:mtg_sensu, UniProtKB:Q60597] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. synonym: "oxoglutarate dehydrogenase complex (sensu Eukaryota)" EXACT [] xref: GO:0009353 is_a: CCO:C0001848 ! mitochondrial part is_a: CCO:C0001915 ! oxoglutarate dehydrogenase complex relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000599 name: DNA polymerase V complex namespace: cellular_component def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196] xref: GO:0009355 is_a: CCO:C0001651 ! DNA polymerase complex [Term] id: CCO:C0000600 name: aminodeoxychorismate synthase complex namespace: cellular_component def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344] synonym: "4-amino-4-deoxychorismate synthase complex" RELATED [] synonym: "ADC synthase complex" EXACT [] synonym: "p-aminobenzoate synthetase complex" RELATED [] xref: GO:0009356 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000601 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69] xref: GO:0009357 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000602 name: polyphosphate kinase complex namespace: cellular_component def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah] comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'. subset: gosubset_prok xref: GO:0009358 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000603 name: Type II site-specific deoxyribonuclease complex namespace: cellular_component def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] subset: gosubset_prok synonym: "Type II restriction enzyme complex" EXACT [] xref: GO:0009359 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000604 name: DNA polymerase III complex namespace: cellular_component def: "A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:11525729, PMID:12940977] subset: gosubset_prok xref: GO:0009360 is_a: CCO:C0001651 ! DNA polymerase complex [Term] id: CCO:C0000605 name: succinate-CoA ligase complex (ADP-forming) namespace: cellular_component def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [EC:6.2.1.5, GOC:jl] subset: gosubset_prok xref: GO:0009361 is_a: CCO:C0001687 ! succinate-CoA ligase complex [Term] id: CCO:C0000606 name: protein histidine kinase complex namespace: cellular_component def: "A complex that possesses protein histidine kinase activity." [GOC:mah] xref: GO:0009365 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000607 name: enterobactin synthetase complex namespace: cellular_component def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [UniProtKB:P15048] subset: gosubset_prok synonym: "enterochelin synthetase complex" EXACT [] xref: GO:0009366 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000608 name: prepilin peptidase complex namespace: cellular_component def: "An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43] xref: GO:0009367 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part [Term] id: CCO:C0000609 name: endopeptidase Clp complex namespace: cellular_component def: "An enzymatically active or inactive multimeric complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits." [PMID:11352464] subset: goslim_pir subset: gosubset_prok xref: GO:0009368 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000610 name: ferredoxin hydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.12.7.2] subset: gosubset_prok synonym: "hydrogenase complex" BROAD [] xref: GO:0009375 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000611 name: HslUV protease complex namespace: cellular_component def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other Clp family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, six identical subunits of both the ATPase, ClpY, and the protease, ClpQ, self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, form a dumbbell-shaped complex." [PMID:12670962] subset: gosubset_prok synonym: "ClpYQ protease complex" EXACT [] xref: GO:0009376 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000612 name: Holliday junction helicase complex namespace: cellular_component def: "A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA ." [PMID:16935884, PMID:9442895] subset: gosubset_prok xref: GO:0009379 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0001998 ! Holliday junction resolvase complex [Term] id: CCO:C0000613 name: excinuclease repair complex namespace: cellular_component def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and one B subunit bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between subunit B and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:15192705] subset: gosubset_prok synonym: "excinuclease ABC complex" EXACT [] synonym: "UvrABC excinuclease complex" EXACT [] xref: GO:0009380 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000614 name: imidazoleglycerol-phosphate synthase complex namespace: cellular_component def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah] comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'. subset: gosubset_prok synonym: "imidazoleglycerol phosphate synthase complex" EXACT [] xref: GO:0009382 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000615 name: dimethyl sulfoxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188] synonym: "dimethyl sulphoxide reductase complex" EXACT [] xref: GO:0009390 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000616 name: fimbrial shaft namespace: cellular_component def: "The long, slender, mid section of a fimbrium." [GOC:jl] subset: gosubset_prok xref: GO:0009418 is_a: CCO:C0001862 ! fimbrial part [Term] id: CCO:C0000617 name: fimbrial tip namespace: cellular_component def: "The pointed extremity furthest from the cell of a fimbrium." [GOC:jl] subset: gosubset_prok xref: GO:0009419 is_a: CCO:C0001862 ! fimbrial part [Term] id: CCO:C0000622 name: flagellin-based flagellum basal body namespace: cellular_component def: "One of the three major substructures of the flagellin-based flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring)." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body (sensu Bacteria)" EXACT [] xref: GO:0009425 is_a: CCO:C0001879 ! flagellin-based flagellum part [Term] id: CCO:C0000629 name: microtubule-based flagellum namespace: cellular_component def: "A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules." [GOC:mtg_sensu, ISBN:0815316194] comment: See also the cellular component term 'cilium ; GO:0005929'. synonym: "flagellum (sensu Eukaryota)" EXACT [] xref: GO:0009434 is_a: CCO:C0000896 ! flagellum is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0000630 name: amyloplast namespace: cellular_component def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031] xref: GO:0009501 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0000632 name: thylakoid light-harvesting complex namespace: cellular_component def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [GOC:mtg_sensu, ISBN:0198547684] synonym: "light-harvesting complex (sensu Viridiplantae)" EXACT [] xref: GO:0009503 is_a: CCO:C0000943 ! light-harvesting complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0000663 ! chloroplast thylakoid membrane [Term] id: CCO:C0000633 name: cell plate namespace: cellular_component def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684] xref: GO:0009504 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000635 name: plasmodesma namespace: cellular_component def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "plasmodesmata" EXACT [] xref: GO:0009506 is_a: CCO:C0000463 ! intercellular junction relationship: part_of CCO:C0002026 ! symplast [Term] id: CCO:C0000636 name: chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] xref: GO:0009507 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0000637 name: plastid chromosome namespace: cellular_component def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943883999] xref: GO:0009508 is_a: CCO:C0000296 ! chromosome is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0001679 ! plastid nucleoid [Term] id: CCO:C0000638 name: chromoplast namespace: cellular_component def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208] xref: GO:0009509 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0000639 name: plasmodesmatal desmotubule namespace: cellular_component def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "desmotubule central rod" RELATED [] xref: GO:0009510 xref: GO:0009572 is_a: CCO:C0001851 ! endoplasmic reticulum part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000635 ! plasmodesma [Term] id: CCO:C0000640 name: plasmodesmatal endoplasmic reticulum namespace: cellular_component def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai] synonym: "plasmodesmatal ER" EXACT [] xref: GO:0009511 is_a: CCO:C0000364 ! endoplasmic reticulum is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000639 ! plasmodesmatal desmotubule [Term] id: CCO:C0000641 name: cytochrome b6f complex namespace: cellular_component def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943883999, PMID:16228398, PMID:16352458] subset: gosubset_prok synonym: "cyt b(6)f complex" EXACT [] synonym: "cyt b6-f complex" EXACT [] synonym: "cyt b6/f complex" EXACT [] synonym: "cyt b6f complex" EXACT [] synonym: "cytochrome b(6)f complex" EXACT [] synonym: "cytochrome b6-f complex" EXACT [] synonym: "cytochrome b6/f complex" EXACT [] xref: GO:0009512 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001855 ! thylakoid part [Term] id: CCO:C0000642 name: etioplast namespace: cellular_component def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943883999] xref: GO:0009513 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0000643 name: glyoxysome namespace: cellular_component def: "A microbody that contains the enzymes of the glyoxylate pathway." [ISBN:0140514031] xref: GO:0009514 is_a: CCO:C0001652 ! microbody [Term] id: CCO:C0000644 name: granal stacked thylakoid namespace: cellular_component def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr] synonym: "chloroplast stacked thylakoid" EXACT [] xref: GO:0009515 is_a: CCO:C0000662 ! chloroplast thylakoid relationship: part_of CCO:C0000669 ! granum [Term] id: CCO:C0000645 name: leucoplast namespace: cellular_component def: "Colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943883999] xref: GO:0009516 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0000646 name: PSII associated light-harvesting complex II namespace: cellular_component def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089] synonym: "LHCII" EXACT [] xref: GO:0009517 is_a: CCO:C0000632 ! thylakoid light-harvesting complex [Term] id: CCO:C0000647 name: PSI associated light-harvesting complex I namespace: cellular_component def: "Protein-pigment complex associated with photosystem I." [GOC:lr] synonym: "LHCI" EXACT [] xref: GO:0009518 is_a: CCO:C0000632 ! thylakoid light-harvesting complex [Term] id: CCO:C0000648 name: middle lamella namespace: cellular_component def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208] xref: GO:0009519 is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0000649 name: photosystem namespace: cellular_component def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] subset: goslim_pir subset: gosubset_prok synonym: "reaction center (sensu Gram-negative Bacteria)" NARROW [] synonym: "reaction center (sensu Proteobacteria)" NARROW [] synonym: "reaction centre (sensu Gram-negative Bacteria)" NARROW [] synonym: "reaction centre (sensu Proteobacteria)" NARROW [] xref: GO:0009521 xref: GO:0030090 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0002137 ! photosynthetic membrane [Term] id: CCO:C0000650 name: photosystem I namespace: cellular_component def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] subset: gosubset_prok xref: GO:0009522 is_a: CCO:C0000649 ! photosystem [Term] id: CCO:C0000651 name: photosystem II namespace: cellular_component def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949] subset: gosubset_prok xref: GO:0009523 is_a: CCO:C0000649 ! photosystem [Term] id: CCO:C0000652 name: phragmoplast namespace: cellular_component def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208] xref: GO:0009524 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000653 name: phragmosome namespace: cellular_component def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943883999] xref: GO:0009525 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000654 name: plastid envelope namespace: cellular_component def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] xref: GO:0009526 is_a: CCO:C0001360 ! organelle envelope is_a: CCO:C0001854 ! plastid part [Term] id: CCO:C0000655 name: plastid outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr] xref: GO:0009527 is_a: CCO:C0001361 ! organelle outer membrane is_a: CCO:C0001634 ! plastid membrane [Term] id: CCO:C0000656 name: plastid inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr] xref: GO:0009528 is_a: CCO:C0000897 ! organelle inner membrane is_a: CCO:C0001634 ! plastid membrane [Term] id: CCO:C0000657 name: plastid intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr] synonym: "plastid envelope lumen" EXACT [] xref: GO:0009529 is_a: CCO:C0001363 ! organelle envelope lumen is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000654 ! plastid envelope [Term] id: CCO:C0000658 name: primary cell wall namespace: cellular_component def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jic, http://cancerweb.ncl.ac.uk] xref: GO:0009530 is_a: CCO:C0001985 ! middle lamella-containing extracellular matrix is_a: CCO:C0002158 ! plant-type cell wall [Term] id: CCO:C0000659 name: secondary cell wall namespace: cellular_component def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jic, http://cancerweb.ncl.ac.uk] xref: GO:0009531 is_a: CCO:C0001985 ! middle lamella-containing extracellular matrix is_a: CCO:C0002158 ! plant-type cell wall [Term] id: CCO:C0000660 name: plastid stroma namespace: cellular_component def: "The proteinaceous ground substance of plastids." [ISBN:047142520] xref: GO:0009532 is_a: CCO:C0001854 ! plastid part [Term] id: CCO:C0000661 name: chloroplast stromal thylakoid namespace: cellular_component def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943883999] xref: GO:0009533 is_a: CCO:C0000662 ! chloroplast thylakoid relationship: part_of CCO:C0000681 ! chloroplast stroma [Term] id: CCO:C0000662 name: chloroplast thylakoid namespace: cellular_component def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana." [GOC:mtg_sensu, ISBN:0943883999] synonym: "thylakoid (sensu Viridiplantae)" EXACT [] xref: GO:0009534 is_a: CCO:C0001368 ! plastid thylakoid is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0000663 name: chloroplast thylakoid membrane namespace: cellular_component def: "The pigmented membrane of a chloroplast thylakoid." [GOC:lr, GOC:mtg_sensu] synonym: "thylakoid membrane (sensu Viridiplantae)" EXACT [] xref: GO:0009535 is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0002020 ! plastid thylakoid membrane relationship: part_of CCO:C0000662 ! chloroplast thylakoid [Term] id: CCO:C0000664 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: GO:0009536 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0000665 name: proplastid namespace: cellular_component def: "The precursor of other plastids." [ISBN:0943883999] xref: GO:0009537 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0000666 name: photosystem I reaction center namespace: cellular_component def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399] subset: gosubset_prok synonym: "photosystem I reaction centre" EXACT [] xref: GO:0009538 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000650 ! photosystem I [Term] id: CCO:C0000667 name: photosystem II reaction center namespace: cellular_component def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399] subset: gosubset_prok synonym: "photosystem II reaction centre" EXACT [] xref: GO:0009539 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000651 ! photosystem II [Term] id: CCO:C0000668 name: etioplast prolamellar body namespace: cellular_component def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031] xref: GO:0009541 is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000642 ! etioplast [Term] id: CCO:C0000669 name: granum namespace: cellular_component def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:014051403] xref: GO:0009542 is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0000670 name: chloroplast thylakoid lumen namespace: cellular_component def: "The cavity enclosed within the chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:006501037] synonym: "thylakoid lumen (sensu Viridiplantae)" EXACT [] xref: GO:0009543 is_a: CCO:C0001370 ! plastid thylakoid lumen is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000662 ! chloroplast thylakoid [Term] id: CCO:C0000671 name: chloroplast ATP synthase complex namespace: cellular_component def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:019854768] xref: GO:0009544 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0000663 ! chloroplast thylakoid membrane [Term] id: CCO:C0000672 name: elaioplast namespace: cellular_component def: "A leucoplast in which oil is stored." [ISBN:0140514031] xref: GO:0009545 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0000673 name: plasmodesmatal cytoplasmic sleeve namespace: cellular_component def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "plasmodesmatal cytoplasmic annulus" EXACT [] xref: GO:0009546 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000635 ! plasmodesma [Term] id: CCO:C0000674 name: plastid ribosome namespace: cellular_component def: "A ribosome contained within a plastid." [GOC:tair_curators] xref: GO:0009547 is_a: CCO:C0000057 ! organellar ribosome is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000660 ! plastid stroma [Term] id: CCO:C0000675 name: plasmodesmatal plasma membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah] xref: GO:0009548 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000635 ! plasmodesma [Term] id: CCO:C0000676 name: cellulose microfibril namespace: cellular_component def: "Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls where it is found as microfibrils laid down in orthogonal layers. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the protoplast." [GOC:jic, http://cancerweb.ncl.ac.uk, ISBN:0943088399] xref: GO:0009549 is_a: CCO:C0000169 ! microfibril is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0000658 ! primary cell wall relationship: part_of CCO:C0000659 ! secondary cell wall [Term] id: CCO:C0000677 name: primary plasmodesma namespace: cellular_component def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255] synonym: "simple plasmodesma" EXACT [] xref: GO:0009550 is_a: CCO:C0000635 ! plasmodesma [Term] id: CCO:C0000678 name: secondary plasmodesma namespace: cellular_component def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255] xref: GO:0009551 is_a: CCO:C0000635 ! plasmodesma [Term] id: CCO:C0000679 name: amyloplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] synonym: "amyloplast starch granule" EXACT [] xref: GO:0009568 is_a: CCO:C0001712 ! starch grain relationship: part_of CCO:C0000630 ! amyloplast [Term] id: CCO:C0000680 name: chloroplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "chloroplast starch granule" EXACT [] xref: GO:0009569 is_a: CCO:C0001712 ! starch grain is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0000681 name: chloroplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] xref: GO:0009570 is_a: CCO:C0000660 ! plastid stroma is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0000682 name: proplastid stroma namespace: cellular_component def: "The space enclosed by the double membrane of a proplastid." [GOC:jl] xref: GO:0009571 is_a: CCO:C0000660 ! plastid stroma relationship: part_of CCO:C0000665 ! proplastid [Term] id: CCO:C0000683 name: chloroplast ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] synonym: "ribulose bisphosphate carboxylase complex (sensu Magnoliophyta)" EXACT [] synonym: "RubisCO complex (sensu Magnoliophyta)" EXACT [] xref: GO:0009573 is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0001999 ! ribulose bisphosphate carboxylase complex relationship: part_of CCO:C0000681 ! chloroplast stroma [Term] id: CCO:C0000684 name: preprophase band namespace: cellular_component def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0009574 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000685 name: chromoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl] xref: GO:0009575 is_a: CCO:C0000660 ! plastid stroma relationship: part_of CCO:C0000638 ! chromoplast [Term] id: CCO:C0000686 name: leucoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah] xref: GO:0009576 is_a: CCO:C0000660 ! plastid stroma relationship: part_of CCO:C0000645 ! leucoplast [Term] id: CCO:C0000687 name: elaioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah] xref: GO:0009577 is_a: CCO:C0000660 ! plastid stroma relationship: part_of CCO:C0000672 ! elaioplast [Term] id: CCO:C0000688 name: etioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl] xref: GO:0009578 is_a: CCO:C0000660 ! plastid stroma relationship: part_of CCO:C0000642 ! etioplast [Term] id: CCO:C0000689 name: thylakoid namespace: cellular_component def: "A membraneous cellular structure that bears the photosynthetic pigments in photosynthetic organisms. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "photosynthetic membrane" RELATED [] xref: GO:0009579 is_a: CCO:C0002137 ! photosynthetic membrane [Term] id: CCO:C0000690 name: oxygen evolving complex namespace: cellular_component def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [InterPro:IPR002683] subset: gosubset_prok xref: GO:0009654 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0000651 ! photosystem II [Term] id: CCO:C0000691 name: PSII associated light-harvesting complex II, core complex namespace: cellular_component def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr] subset: gosubset_prok synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW [] xref: GO:0009655 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0000646 ! PSII associated light-harvesting complex II [Term] id: CCO:C0000692 name: PSII associated light-harvesting complex II, peripheral complex namespace: cellular_component def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr] subset: gosubset_prok xref: GO:0009656 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0000646 ! PSII associated light-harvesting complex II [Term] id: CCO:C0000694 name: chloroplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb] synonym: "chloroplast inner envelope" EXACT [] xref: GO:0009706 is_a: CCO:C0000656 ! plastid inner membrane is_a: CCO:C0001362 ! chloroplast membrane [Term] id: CCO:C0000695 name: chloroplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb] synonym: "chloroplast outer envelope" EXACT [] xref: GO:0009707 is_a: CCO:C0000655 ! plastid outer membrane is_a: CCO:C0001362 ! chloroplast membrane [Term] id: CCO:C0000696 name: photosystem I antenna complex namespace: cellular_component def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jic, ISBN:0716731363] xref: GO:0009782 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000650 ! photosystem I [Term] id: CCO:C0000697 name: photosystem II antenna complex namespace: cellular_component def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jic, ISBN:0716731363] xref: GO:0009783 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000651 ! photosystem II [Term] id: CCO:C0000698 name: chloroplastic endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah] xref: GO:0009840 is_a: CCO:C0000609 ! endopeptidase Clp complex is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000681 ! chloroplast stroma [Term] id: CCO:C0000699 name: mitochondrial endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah] xref: GO:0009841 is_a: CCO:C0000609 ! endopeptidase Clp complex is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000700 name: cyanelle namespace: cellular_component def: "Plastid type found in Glaucophyta having unstacked thylakoid membranes bearing phycobilisomes; cyanelles are bound by a double membrane and a peptidoglycan layer." [ISBN:052131687] subset: gosubset_prok xref: GO:0009842 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0000701 name: cyanelle thylakoid namespace: cellular_component def: "Photosynthetic membrane resembling that of cyanobacteria found in the cyanelles of certain algae." [GOC:lr, GOC:mtg_sensu] subset: gosubset_prok synonym: "thylakoid (sensu Glaucocystophyceae)" EXACT [] xref: GO:0009843 is_a: CCO:C0001368 ! plastid thylakoid relationship: part_of CCO:C0000700 ! cyanelle [Term] id: CCO:C0000702 name: external side of plasma membrane namespace: cellular_component def: "The side of the plasma membrane that is opposite to the side that faces the cytoplasm." [GOC:tb] subset: gosubset_prok synonym: "juxtamembrane" BROAD [] synonym: "outer surface of cytoplasmic membrane" EXACT [] xref: GO:0009897 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000709 ! cell surface [Term] id: CCO:C0000703 name: internal side of plasma membrane namespace: cellular_component def: "The side of the plasma membrane that faces the cytoplasm." [GOC:tb] subset: gosubset_prok synonym: "juxtamembrane" BROAD [] xref: GO:0009898 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000704 name: auxin efflux carrier complex namespace: cellular_component def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496] xref: GO:0009921 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000705 name: fatty acid elongase complex namespace: cellular_component def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb] xref: GO:0009923 is_a: CCO:C0001221 ! cytosolic fatty acid synthase complex [Term] id: CCO:C0000706 name: basal plasma membrane namespace: cellular_component def: "Part of the plasma membrane at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] xref: GO:0009925 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000780 ! basolateral plasma membrane relationship: part_of CCO:C0001897 ! basal part of cell [Term] id: CCO:C0000707 name: longitudinal side of cell surface namespace: cellular_component def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm] synonym: "longitudinal side of cell surface (sensu Magnoliophyta)" RELATED [] xref: GO:0009930 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0000709 ! cell surface [Term] id: CCO:C0000708 name: chloroplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] xref: GO:0009941 is_a: CCO:C0000654 ! plastid envelope is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0000709 name: cell surface namespace: cellular_component def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] comment: Note that this term is intended to annotate gene products that are attached to the plasma membrane or cell wall. subset: goslim_goa subset: goslim_pir subset: gosubset_prok synonym: "cell associated" EXACT [] synonym: "cell bound" EXACT [] synonym: "cell surface (sensu Magnoliophyta)" EXACT [] xref: GO:0009928 xref: GO:0009929 xref: GO:0009986 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000710 name: cortical microtubule, transverse to long axis namespace: cellular_component def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399] synonym: "cortical microtubule (sensu Viridiplantae)" EXACT [] xref: GO:0010005 is_a: CCO:C0002014 ! cortical microtubule [Term] id: CCO:C0000711 name: Toc complex namespace: cellular_component def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606] xref: GO:0010006 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000695 ! chloroplast outer membrane [Term] id: CCO:C0000712 name: magnesium chelatase complex namespace: cellular_component def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180] xref: GO:0010007 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0000713 name: endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an endosome." [GOC:mah] xref: GO:0010008 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001859 ! endosomal part relationship: location_of CCO:B0001903 ! STEA3_HUMAN relationship: location_of CCO:B0001980 ! DP13B_HUMAN relationship: location_of CCO:B0002148 ! CHM1A_HUMAN relationship: location_of CCO:B0011567 ! DP13A_HUMAN-Phosphoserine691 [Term] id: CCO:C0000714 name: external side of endosome membrane namespace: cellular_component def: "The external (cytoplasmic face) of an endosome membrane." [GOC:lr] xref: GO:0010009 is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001859 ! endosomal part relationship: part_of CCO:C0000713 ! endosome membrane [Term] id: CCO:C0000715 name: ER body namespace: cellular_component def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182] synonym: "endoplasmic reticulum body" EXACT [] xref: GO:0010168 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000716 name: myrosinase complex namespace: cellular_component def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349] synonym: "thioglucosidase complex" EXACT [] xref: GO:0010169 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000717 name: glucose-1-phosphate adenylyltransferase complex namespace: cellular_component def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181] subset: gosubset_prok xref: GO:0010170 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000718 name: plastid pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637] synonym: "dehydrogenase complex (sensu Viridiplantae)" EXACT [] xref: GO:0010240 is_a: CCO:C0001854 ! plastid part is_a: CCO:C0001917 ! pyruvate dehydrogenase complex [Term] id: CCO:C0000719 name: chloroplast outer membrane translocon namespace: cellular_component def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338] xref: GO:0010278 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000695 ! chloroplast outer membrane [Term] id: CCO:C0000720 name: senescence associated vacuole namespace: cellular_component def: "Vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448] xref: GO:0010282 is_a: CCO:C0000061 ! lytic vacuole [Term] id: CCO:C0000721 name: plastoglobule namespace: cellular_component def: "Plastoglobules (PG) are lipoprotein particles present in chloroplasts. They are rich in non-polar lipids (triacylglycerols, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:TAIR_curator, PMID:16461379] xref: GO:0010287 is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0000722 name: pyrophosphate-dependent phosphofructokinase complex namespace: cellular_component def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409] subset: goslim_pir synonym: "PFK complex" RELATED [] xref: GO:0010316 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000723 name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex namespace: cellular_component def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, alpha-subunit" RELATED [] xref: GO:0010317 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000722 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: CCO:C0000724 name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex namespace: cellular_component def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, beta-subunit" RELATED [] xref: GO:0010318 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000722 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: CCO:C0000725 name: stromule namespace: cellular_component def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010] synonym: "Stroma-filled tubule" RELATED [] xref: GO:0010319 is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000654 ! plastid envelope [Term] id: CCO:C0000726 name: cellulose synthase complex namespace: cellular_component def: "The multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238] synonym: "cellulose synthase complex (sensu Viridiplantae)" EXACT [] xref: GO:0010330 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000727 name: external side of cell wall namespace: cellular_component def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb] xref: GO:0010339 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0000709 ! cell surface [Term] id: CCO:C0000728 name: extracellular isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators] subset: gosubset_prok xref: GO:0010367 is_a: CCO:C0001710 ! isoamylase complex is_a: CCO:C0001840 ! extracellular region part [Term] id: CCO:C0000729 name: chloroplast isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localised." [GOC:tair_curators] subset: gosubset_prok xref: GO:0010368 is_a: CCO:C0001710 ! isoamylase complex is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0000730 name: chromocenter namespace: cellular_component def: "A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888] xref: GO:0010369 is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0000731 name: perinucleolar chromocenter namespace: cellular_component def: "A chromocenter adjacent to the nucleolus." [PMID:15805479] xref: GO:0010370 is_a: CCO:C0000730 ! chromocenter [Term] id: CCO:C0000732 name: nuclear dicing body namespace: cellular_component def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570] synonym: "D body" EXACT [] xref: GO:0010445 is_a: CCO:C0000817 ! nuclear body [Term] id: CCO:C0000733 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_candida subset: goslim_yeast xref: GO:0012505 is_a: CCO:C0001882 ! cell part relationship: location_of CCO:B0002148 ! CHM1A_HUMAN [Term] id: CCO:C0000734 name: vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah] xref: GO:0012506 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0000733 ! endomembrane system relationship: part_of CCO:C0002125 ! membrane-bounded vesicle [Term] id: CCO:C0000735 name: ER to Golgi transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai] synonym: "COPII coated vesicle membrane" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT [] synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT [] synonym: "ER-Golgi transport vesicle membrane" EXACT [] xref: GO:0012507 xref: GO:0030664 is_a: CCO:C0001023 ! transport vesicle membrane is_a: CCO:C0001025 ! Golgi-associated vesicle membrane is_a: CCO:C0001027 ! coated vesicle membrane relationship: part_of CCO:C0000979 ! ER to Golgi transport vesicle [Term] id: CCO:C0000736 name: Golgi to ER transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai] synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" EXACT [] synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" EXACT [] synonym: "Golgi-ER transport vesicle membrane" EXACT [] xref: GO:0012508 is_a: CCO:C0001023 ! transport vesicle membrane is_a: CCO:C0001025 ! Golgi-associated vesicle membrane is_a: CCO:C0001028 ! COPI coated vesicle membrane relationship: part_of CCO:C0000986 ! Golgi to ER transport vesicle [Term] id: CCO:C0000737 name: inter-Golgi transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai] xref: GO:0012509 is_a: CCO:C0001023 ! transport vesicle membrane is_a: CCO:C0001025 ! Golgi-associated vesicle membrane is_a: CCO:C0001028 ! COPI coated vesicle membrane relationship: part_of CCO:C0000987 ! inter-Golgi transport vesicle [Term] id: CCO:C0000738 name: trans-Golgi network transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai] synonym: "TGN transport vesicle membrane" EXACT [] xref: GO:0012510 is_a: CCO:C0001023 ! transport vesicle membrane is_a: CCO:C0001025 ! Golgi-associated vesicle membrane is_a: CCO:C0001029 ! clathrin coated vesicle membrane relationship: part_of CCO:C0000984 ! trans-Golgi network transport vesicle [Term] id: CCO:C0000739 name: monolayer-surrounded lipid storage body namespace: cellular_component def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. A droplet of triacylglycerol surrounded by a monolayer of phospholipids, interacting with the triacylglycerols and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372] synonym: "lipid storage body (sensu Viridiplantae)" EXACT [] synonym: "oil body" EXACT [] synonym: "oleosome" EXACT [] synonym: "spherosome" EXACT [] xref: GO:0009520 xref: GO:0012511 is_a: CCO:C0000382 ! lipid particle is_a: CCO:C0001745 ! intracellular organelle [Term] id: CCO:C0000740 name: postsynaptic density namespace: cellular_component def: "The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases." [GOC:ef, GOC:jic, http://molneuro.kaist.ac.kr/psd, http://wikipedia.org, PMID:14532281] xref: GO:0014069 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001875 ! synapse part [Term] id: CCO:C0000741 name: junctional sarcoplasmic reticulum membrane namespace: cellular_component def: "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] xref: GO:0014701 is_a: CCO:C0001507 ! sarcoplasmic reticulum membrane [Term] id: CCO:C0000742 name: free sarcoplasmic reticulum membrane namespace: cellular_component def: "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] xref: GO:0014702 is_a: CCO:C0001507 ! sarcoplasmic reticulum membrane [Term] id: CCO:C0000743 name: intercalated disc namespace: cellular_component def: "Specialised type of cell-cell junction in cardiac muscle, which mediates mechanical and electrochemical integration between the individual cardiomyocytes. Consist of three different kinds of substructures: adherens junctions, desmosomes and gap junctions." [GOC:mtg_muscle] xref: GO:0014704 is_a: CCO:C0000936 ! cell junction [Term] id: CCO:C0000744 name: C zone namespace: cellular_component def: "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin." [GOC:mtg_muscle] xref: GO:0014705 is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0001326 ! A band [Term] id: CCO:C0000745 name: spectrin-associated cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane." [GOC:mtg_muscle, PMID:15970557] xref: GO:0014731 is_a: CCO:C0000421 ! cytoskeleton [Term] id: CCO:C0000746 name: longitudinal sarcoplasmic reticulum namespace: cellular_component def: "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle] xref: GO:0014801 is_a: CCO:C0000802 ! sarcoplasmic reticulum [Term] id: CCO:C0000747 name: terminal cisterna namespace: cellular_component def: "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release." [GOC:mtg_muscle] xref: GO:0014802 is_a: CCO:C0000802 ! sarcoplasmic reticulum [Term] id: CCO:C0000748 name: longitudinal sarcoplasmic reticulum lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lume contained within the terminal cisternae." [GOC:mtg_muscle] xref: GO:0014803 is_a: CCO:C0001508 ! sarcoplasmic reticulum lumen relationship: part_of CCO:C0000746 ! longitudinal sarcoplasmic reticulum [Term] id: CCO:C0000749 name: terminal cisterna lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin." [GOC:mtg_muscle] xref: GO:0014804 is_a: CCO:C0001508 ! sarcoplasmic reticulum lumen relationship: part_of CCO:C0000747 ! terminal cisterna [Term] id: CCO:C0000750 name: Cajal body namespace: cellular_component def: "A class of nuclear body, first seen after silver staining by Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [http://genetics.cwru.edu/matera3.html, PMID:10944589, PMID:11031238, PMID:7559785] synonym: "coiled body" EXACT [] synonym: "Gems" EXACT [] xref: GO:0015030 is_a: CCO:C0000817 ! nuclear body [Term] id: CCO:C0000751 name: methane monooxygenase complex namespace: cellular_component def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [BRENDA:1.14.13.25, GOC:mah] subset: gosubset_prok xref: GO:0015050 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000752 name: type II protein secretion system complex namespace: cellular_component def: "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of secreted proteins from the cytoplasm into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane." [PMID:16448494] subset: gosubset_prok synonym: "general secretion pathway-associated complex" RELATED [] synonym: "main terminal branch" EXACT [] synonym: "MTB" EXACT [] synonym: "Sec-dependent secretion system-associated complex" RELATED [] synonym: "T2SS-associated complexes" EXACT [] synonym: "type II protein (Sec) secretion system complex" EXACT [] xref: GO:0015627 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000753 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0395825172] xref: GO:0015629 is_a: CCO:C0000421 ! cytoskeleton relationship: location_of CCO:B0002257 ! CD2AP_HUMAN [Term] id: CCO:C0000754 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] xref: GO:0015630 is_a: CCO:C0000421 ! cytoskeleton relationship: location_of CCO:B0001701 ! CCNA1_HUMAN relationship: location_of CCO:B0011243 ! CKAP5_HUMAN-Phosphoserine816 relationship: location_of CCO:B0011263 ! CLIP1_HUMAN-Phosphoserine200 [Term] id: CCO:C0000755 name: large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribosomal large subunit" EXACT [] xref: GO:0015934 is_a: CCO:C0001567 ! ribosomal subunit [Term] id: CCO:C0000756 name: small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a ribosome." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "ribosomal small subunit" EXACT [] xref: GO:0015935 is_a: CCO:C0001567 ! ribosomal subunit is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000757 name: Nebenkern namespace: cellular_component def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] xref: GO:0016006 is_a: CCO:C0000325 ! mitochondrion [Term] id: CCO:C0000758 name: mitochondrial derivative namespace: cellular_component def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma] xref: GO:0016007 is_a: CCO:C0000325 ! mitochondrion [Term] id: CCO:C0000759 name: major mitochondrial derivative namespace: cellular_component def: "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative." [GOC:mah, PMID:17123504] xref: GO:0016008 is_a: CCO:C0000758 ! mitochondrial derivative [Term] id: CCO:C0000760 name: minor mitochondrial derivative namespace: cellular_component def: "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation." [GOC:mah, PMID:17123504] xref: GO:0016009 is_a: CCO:C0000758 ! mitochondrial derivative [Term] id: CCO:C0000761 name: dystrophin-associated glycoprotein complex namespace: cellular_component def: "A multiprotein complex that forms the critical link between the cytoskeleton and extracellular matrix; typical of, but not confined, to muscle cells. The constituents of the complex are somewhat tissue specific. The rod-like dystrophin forms a link between the actin cytoskeleton and the plasma membrane; links between dystrophin and the extracellular matrix are provided by the sarcoglycan complex." [http://www.dmd.nl/dap.html] subset: goslim_pir synonym: "DGC complex" EXACT [] xref: GO:0016010 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000228 ! basal lamina [Term] id: CCO:C0000762 name: dystroglycan complex namespace: cellular_component def: "Includes alpha- and beta-dystroglycan; alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [http://www.dmd.nl/dap.html] xref: GO:0016011 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000761 ! dystrophin-associated glycoprotein complex [Term] id: CCO:C0000763 name: sarcoglycan complex namespace: cellular_component def: "Formed of five N-glycosylated sarcoglycans: alpha-, beta-, gamma-, delta-, and epsilon sarcoglycan, single-pass transmembrane proteins that form a complex which is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [http://www.dmd.nl/dap.html] xref: GO:0016012 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000762 ! dystroglycan complex [Term] id: CCO:C0000764 name: syntrophin complex namespace: cellular_component def: "Includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/dap.html] xref: GO:0016013 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000761 ! dystrophin-associated glycoprotein complex [Term] id: CCO:C0000765 name: dystrobrevin complex namespace: cellular_component def: "A complex of alpha- and beta-dystrobrevin." [http://www.dmd.nl/dap.html] xref: GO:0016014 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000761 ! dystrophin-associated glycoprotein complex [Term] id: CCO:C0000766 name: membrane namespace: cellular_component def: "Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0016020 is_a: CCO:C0001882 ! cell part relationship: location_of CCO:B0001362 ! EREG_HUMAN relationship: location_of CCO:B0001401 ! GAS2_HUMAN relationship: location_of CCO:B0001428 ! ERN1_HUMAN relationship: location_of CCO:B0001453 ! DIRA3_HUMAN relationship: location_of CCO:B0001470 ! EGF_HUMAN relationship: location_of CCO:B0001672 ! GAS1_HUMAN relationship: location_of CCO:B0001737 ! STRN3_HUMAN relationship: location_of CCO:B0001758 ! ULA1_HUMAN relationship: location_of CCO:B0001802 ! CD5R1_HUMAN relationship: location_of CCO:B0001806 ! DHC24_HUMAN relationship: location_of CCO:B0001899 ! DAB2P_HUMAN relationship: location_of CCO:B0001903 ! STEA3_HUMAN relationship: location_of CCO:B0001904 ! KCD11_HUMAN relationship: location_of CCO:B0001927 ! Q70WG0_HUMAN relationship: location_of CCO:B0001980 ! DP13B_HUMAN relationship: location_of CCO:B0002064 ! GML_HUMAN relationship: location_of CCO:B0002094 ! LZTS2_HUMAN relationship: location_of CCO:B0002110 ! CADM1_HUMAN relationship: location_of CCO:B0002112 ! PAR6G_HUMAN relationship: location_of CCO:B0002148 ! CHM1A_HUMAN relationship: location_of CCO:B0002150 ! PAR6A_HUMAN relationship: location_of CCO:B0002175 ! NSMA2_HUMAN relationship: location_of CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 relationship: location_of CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 relationship: location_of CCO:B0011567 ! DP13A_HUMAN-Phosphoserine691 relationship: location_of CCO:B0012757 ! MADD_HUMAN-Phosphoserine1059 relationship: location_of CCO:B0013046 ! MTUS1_HUMAN-Phosphoserine1264 relationship: location_of CCO:B0013709 ! RAP1A_HUMAN-Cysteine methyl ester181 relationship: location_of CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 relationship: location_of CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438 relationship: location_of CCO:B0026256 ! RPRM_HUMAN relationship: location_of CCO:B0026380 ! JUB_HUMAN-Phosphoserine119 relationship: location_of CCO:B0035985 ! ACVR1_HUMAN-Phosphoserine501 relationship: location_of CCO:B0035997 ! DCC_HUMAN-Phosphoserine1073 [Term] id: CCO:C0000767 name: integral to membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators] subset: gosubset_prok synonym: "transmembrane" EXACT [] xref: GO:0016021 is_a: CCO:C0001148 ! intrinsic to membrane relationship: location_of CCO:B0001362 ! EREG_HUMAN relationship: location_of CCO:B0001428 ! ERN1_HUMAN relationship: location_of CCO:B0001470 ! EGF_HUMAN relationship: location_of CCO:B0001806 ! DHC24_HUMAN relationship: location_of CCO:B0001903 ! STEA3_HUMAN relationship: location_of CCO:B0002110 ! CADM1_HUMAN relationship: location_of CCO:B0002175 ! NSMA2_HUMAN relationship: location_of CCO:B0012757 ! MADD_HUMAN-Phosphoserine1059 relationship: location_of CCO:B0026256 ! RPRM_HUMAN relationship: location_of CCO:B0035985 ! ACVR1_HUMAN-Phosphoserine501 relationship: location_of CCO:B0035997 ! DCC_HUMAN-Phosphoserine1073 [Term] id: CCO:C0000768 name: endoplasmic reticulum cisterna namespace: cellular_component def: "The flattened sac-like space enclosed between paired membrane of the endoplasmic reticulum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ER cisterna" EXACT [] xref: GO:0016022 is_a: CCO:C0001851 ! endoplasmic reticulum part [Term] id: CCO:C0000770 name: inaD signaling complex namespace: cellular_component def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [FB:FBrf0105321, GOC:hb, PMID:9010208] synonym: "inaD signalling complex" EXACT [] xref: GO:0016027 is_a: CCO:C0000899 ! extrinsic to plasma membrane is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000771 ! rhabdomere [Term] id: CCO:C0000771 name: rhabdomere namespace: cellular_component def: "The specialized microvillar organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, PMID:8646774] subset: goslim_pir xref: GO:0016028 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0000772 name: subrhabdomeral cisterna namespace: cellular_component def: "The internal stores of calcium found at the base of the rhabdomere." [PMID:8646774] xref: GO:0016029 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000771 ! rhabdomere [Term] id: CCO:C0000773 name: zeta DNA polymerase complex namespace: cellular_component def: "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464] xref: GO:0016035 is_a: CCO:C0001651 ! DNA polymerase complex is_a: CCO:C0001865 ! intracellular organelle part [Term] id: CCO:C0000774 name: procollagen-proline, 2-oxoglutarate-4-dioxygenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate." [EC:1.14.11.2] xref: GO:0016222 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000775 name: inclusion body namespace: cellular_component def: "Intracellular foci at which aggregated proteins have been sequestered." [PMID:11121744] xref: GO:0016234 is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000776 name: aggresome namespace: cellular_component def: "An inclusion body resulting from dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744] xref: GO:0016235 is_a: CCO:C0000775 ! inclusion body [Term] id: CCO:C0000777 name: prefoldin complex namespace: cellular_component def: "A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, UniProtKB:O15212] subset: gosubset_prok synonym: "GIM complex" NARROW [] xref: GO:0016272 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part relationship: location_of CCO:B0001420 ! PFD1_HUMAN [Term] id: CCO:C0000778 name: eukaryotic translation initiation factor 4F complex namespace: cellular_component def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, UniProtKB:P41110] synonym: "eIF-4F" EXACT [] synonym: "eukaryotic translation initiation factor 4 complex" BROAD [] xref: GO:0016281 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000779 name: eukaryotic 43S preinitiation complex namespace: cellular_component def: "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] synonym: "eukaryotic 43S pre-initiation complex" EXACT [] xref: GO:0016282 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000780 name: basolateral plasma membrane namespace: cellular_component def: "Part of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] xref: GO:0016323 is_a: CCO:C0001877 ! plasma membrane part relationship: location_of CCO:B0002110 ! CADM1_HUMAN relationship: location_of CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 [Term] id: CCO:C0000781 name: apical plasma membrane namespace: cellular_component def: "Part of the plasma membrane at the apical end of the cell." [GOC:curators] xref: GO:0016324 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0001896 ! apical part of cell [Term] id: CCO:C0000782 name: apicolateral plasma membrane namespace: cellular_component def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] subset: gosubset_prok xref: GO:0016327 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000783 name: lateral plasma membrane namespace: cellular_component def: "The membranes on the sides of epithelial cells which lie at the interface of adjacent cells." [GOC:hb] xref: GO:0016328 is_a: CCO:C0001877 ! plasma membrane part relationship: location_of CCO:B0010567 ! APC_HUMAN-Phosphoserine1038 [Term] id: CCO:C0000784 name: catenin complex namespace: cellular_component def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] xref: GO:0016342 is_a: CCO:C0000899 ! extrinsic to plasma membrane is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000785 name: nuclear matrix namespace: cellular_component def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] xref: GO:0016363 is_a: CCO:C0001847 ! nuclear part relationship: location_of CCO:B0001451 ! YETS4_HUMAN relationship: location_of CCO:B0001503 ! DPOLA_HUMAN relationship: location_of CCO:B0002148 ! CHM1A_HUMAN relationship: location_of CCO:B0010482 ! AKAP8_HUMAN-Phosphoserine112 relationship: location_of CCO:B0010800 ! BLM_HUMAN-Phosphoserine419 relationship: location_of CCO:B0035935 ! MEN1_HUMAN relationship: part_of CCO:C0001373 ! nuclear lumen [Term] id: CCO:C0000786 name: RNA-induced silencing complex namespace: cellular_component def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] synonym: "RISC complex" EXACT [] xref: GO:0016442 is_a: CCO:C0001205 ! RNAi effector complex [Term] id: CCO:C0000787 name: X chromosome located dosage compensation complex, transcription activating namespace: cellular_component def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome." [GOC:ma, GOC:mtg_sensu] synonym: "dosage compensation complex (sensu Insecta)" EXACT [] xref: GO:0016456 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001953 ! dosage compensation complex relationship: part_of CCO:C0000132 ! X chromosome [Term] id: CCO:C0000788 name: myosin complex namespace: cellular_component def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] xref: GO:0016459 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001849 ! cytoskeletal part relationship: location_of CCO:B0031342 ! MYO16_HUMAN-Phosphotyrosine1432 relationship: location_of CCO:B0036017 ! MYH10_HUMAN-Phosphothreonine1376 relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0000789 name: myosin II complex namespace: cellular_component def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] synonym: "conventional myosin" RELATED [] xref: GO:0016460 is_a: CCO:C0000788 ! myosin complex [Term] id: CCO:C0000790 name: unconventional myosin complex namespace: cellular_component def: "A portmanteau term for myosins other than myosin II." [GOC:ma] comment: Note that this term is retained because it is widely used by biologists. synonym: "non-muscle myosin" RELATED [] xref: GO:0005860 xref: GO:0016461 is_a: CCO:C0000788 ! myosin complex [Term] id: CCO:C0000791 name: chaperonin ATPase complex namespace: cellular_component def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9] xref: GO:0016465 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0000792 name: proton-transporting two-sector ATPase complex namespace: cellular_component def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] subset: goslim_pir subset: gosubset_prok synonym: "hydrogen-transporting two-sector ATPase complex" EXACT [] synonym: "vacuolar hydrogen-transporting ATPase" RELATED [] xref: GO:0016469 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part [Term] id: CCO:C0000793 name: vacuolar proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'. subset: gosubset_prok synonym: "vacuolar hydrogen-translocating V-type ATPase complex" EXACT [] xref: GO:0016471 is_a: CCO:C0001546 ! proton-transporting V-type ATPase complex is_a: CCO:C0001856 ! vacuolar part relationship: part_of CCO:C0000356 ! vacuolar membrane [Term] id: CCO:C0000794 name: sodium ion-transporting two-sector ATPase complex namespace: cellular_component def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431] subset: goslim_pir synonym: "sodium-transporting two-sector ATPase complex" EXACT [] xref: GO:0016472 is_a: CCO:C0000767 ! integral to membrane is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000795 name: sodium ion-transporting F-type ATPase complex namespace: cellular_component def: "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431] synonym: "sodium-translocating F-type ATPase complex" EXACT [] xref: GO:0016473 is_a: CCO:C0000794 ! sodium ion-transporting two-sector ATPase complex [Term] id: CCO:C0000796 name: sodium ion-transporting V-type ATPase complex namespace: cellular_component def: "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565] synonym: "sodium-translocating V-type ATPase complex" EXACT [] xref: GO:0016474 is_a: CCO:C0000794 ! sodium ion-transporting two-sector ATPase complex [Term] id: CCO:C0000797 name: fatty acid beta-oxidation multienzyme complex namespace: cellular_component def: "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma] synonym: "trifunctional enzyme" RELATED [] xref: GO:0016507 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000798 name: core-binding factor complex namespace: cellular_component def: "A heterodimer with alpha- and beta-subunits that binds the core site 5'-PYGPYGGT-3' of several enhancers and promoters; the beta-subunit enhances the DNA binding of the alpha-subunit." [UniProtKB:Q08024] xref: GO:0016513 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0000799 name: SWI/SNF complex namespace: cellular_component def: "Any of a family of protein complexes that regulate transcription by remodeling chromatin. Swi/Snf complexes comprise nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components." [GOC:mah, PMID:12672490] xref: GO:0016514 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0000800 name: interleukin-4 receptor complex namespace: cellular_component def: "Complexes that bind interleukin-4; consist of alpha, beta, and gamma chains and exist in three forms, one containing extracellular transmembrane and cytoplasmic domains, one lacking the cytoplasmic domain and a third that is secreted." [UniProtKB:P16382] xref: GO:0016516 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000801 name: sarcoplasm namespace: cellular_component def: "The cytoplasm of a muscle fiber; includes the sarcoplasmic reticulum." [ISBN:0198547684] xref: GO:0016528 is_a: CCO:C0000324 ! cytoplasm [Term] id: CCO:C0000802 name: sarcoplasmic reticulum namespace: cellular_component def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle fiber; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'. xref: GO:0008221 xref: GO:0016529 is_a: CCO:C0000364 ! endoplasmic reticulum relationship: part_of CCO:C0000801 ! sarcoplasm [Term] id: CCO:C0000803 name: cyclin-dependent protein kinase 5 activator complex namespace: cellular_component def: "A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [UniProtKB:Q62938] xref: GO:0016533 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part relationship: location_of CCO:B0001751 ! CD5R2_HUMAN relationship: location_of CCO:B0001802 ! CD5R1_HUMAN [Term] id: CCO:C0000804 name: Sin3 complex namespace: cellular_component def: "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422] xref: GO:0016580 is_a: CCO:C0000008 ! histone deacetylase complex [Term] id: CCO:C0000805 name: NuRD complex namespace: cellular_component def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569] synonym: "Mi-2 complex" EXACT [] synonym: "NRD complex" EXACT [] synonym: "nucleosome remodeling and histone deacetylation complex" EXACT [] synonym: "SHREC complex" EXACT [] xref: GO:0016581 is_a: CCO:C0000008 ! histone deacetylase complex relationship: location_of CCO:B0001980 ! DP13B_HUMAN relationship: location_of CCO:B0011567 ! DP13A_HUMAN-Phosphoserine691 [Term] id: CCO:C0000806 name: chromatin remodeling complex namespace: cellular_component def: "Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah] subset: goslim_pir synonym: "chromatin remodelling complex" EXACT [] synonym: "nucleosome remodeling complex" EXACT [] xref: GO:0005679 xref: GO:0016585 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0000807 name: RSC complex namespace: cellular_component def: "A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining." [PMID:11937489, PMID:12672490, PMID:15870268, PMID:8980231] xref: GO:0016586 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0000808 name: ISW1 complex namespace: cellular_component def: "A protein complex that contains an ISWI-family ATPase such as Saccharomyces Isw1p, and acts to modify chromatin structure." [GOC:mah, PMID:15020051] xref: GO:0016587 is_a: CCO:C0001107 ! ISWI complex [Term] id: CCO:C0000809 name: NURF complex namespace: cellular_component def: "A four subunit ISWI-containing protein complex that facilitates nucleosome mobility and transcriptional activation in an ATP-dependent manner. In contrast to other chromatin remodeling complexes, the ATPase activity of NURF requires nucleosomes rather than free DNA or histones." [GOC:bf, PMID:10779516, PMID:11279013] synonym: "nucleosome remodeling factor complex" EXACT [] xref: GO:0016589 is_a: CCO:C0001107 ! ISWI complex [Term] id: CCO:C0000810 name: ACF complex namespace: cellular_component def: "A chromatin-remodeling complex that catalyzes the ATP-dependent assembly of periodic nucleosome arrays. In Drosophila, the complex comprises ACF1 and ISWI." [GOC:bf, PMID:12192034] synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" EXACT [] xref: GO:0016590 is_a: CCO:C0000281 ! chromatin assembly complex [Term] id: CCO:C0000811 name: DNA-directed RNA polymerase II, holoenzyme namespace: cellular_component def: "Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, http://en.wikipedia.org/, PMID:15196470] subset: goslim_pir xref: GO:0016591 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0000812 name: Srb-mediator complex namespace: cellular_component def: "A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins." [PMID:9396788] synonym: "CDK8-containing TRAP/mediator complex" EXACT [] synonym: "L mediator complex" EXACT [] xref: GO:0016592 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0000813 name: Cdc73/Paf1 complex namespace: cellular_component def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Hpr1p, Ccr4p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586] xref: GO:0016593 is_a: CCO:C0000523 ! transcription elongation factor complex relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0000815 name: flotillin complex namespace: cellular_component def: "A heteromeric complex of flotillin 1, flotillin 2, caveolin 1 and caveolin 2 within the caveolar membrane." [UniProtKB:O61491] comment: See also the cellular component term 'caveolar membrane ; GO:0016599'. xref: GO:0016600 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000458 ! caveola [Term] id: CCO:C0000816 name: CCAAT-binding factor complex namespace: cellular_component def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [PMID:7828851] xref: GO:0016602 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0000817 name: nuclear body namespace: cellular_component def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] xref: GO:0016604 is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0000818 name: PML body namespace: cellular_component def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585] synonym: "ND10" EXACT [] synonym: "nuclear dot" RELATED [] xref: GO:0016605 is_a: CCO:C0000817 ! nuclear body relationship: location_of CCO:B0010800 ! BLM_HUMAN-Phosphoserine419 [Term] id: CCO:C0000819 name: Lands namespace: cellular_component def: "A class of nuclear body (Lands = LYSP100-associated nuclear domains); they are globular, electron-dense structures that may traffic between the nucleus and cytoplasm; they react against SP140 auto-antibodies." [UniProtKB:Q13342] xref: GO:0016606 is_a: CCO:C0000817 ! nuclear body [Term] id: CCO:C0000820 name: nuclear speck namespace: cellular_component def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] synonym: "nuclear speckle" EXACT [] synonym: "nuclear speckles" EXACT [] synonym: "speckle domain" NARROW [] synonym: "speckle focus" RELATED [] synonym: "splicing speckle" EXACT [] xref: GO:0016607 is_a: CCO:C0000817 ! nuclear body relationship: location_of CCO:B0002065 ! CDC5L_HUMAN [Term] id: CCO:C0000821 name: nitrogenase complex namespace: cellular_component def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525] subset: goslim_pir subset: gosubset_prok xref: GO:0016610 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000822 name: iron-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850] comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells. subset: gosubset_prok xref: GO:0016611 is_a: CCO:C0000821 ! nitrogenase complex [Term] id: CCO:C0000823 name: molybdenum-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1] subset: gosubset_prok synonym: "molybdenum-iron nitrogenase activity" RELATED [] xref: GO:0016612 is_a: CCO:C0000821 ! nitrogenase complex [Term] id: CCO:C0000824 name: vanadium-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027] subset: gosubset_prok synonym: "vanadium-iron nitrogenase activity" RELATED [] xref: GO:0016613 is_a: CCO:C0000821 ! nitrogenase complex [Term] id: CCO:C0000825 name: follicle-stimulating hormone complex namespace: cellular_component def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684] xref: GO:0016914 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part [Term] id: CCO:C0000826 name: glycine-gated chloride channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah] xref: GO:0016935 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000827 name: kinesin I complex namespace: cellular_component def: "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] xref: GO:0016938 is_a: CCO:C0000431 ! kinesin complex [Term] id: CCO:C0000828 name: kinesin II complex namespace: cellular_component def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] xref: GO:0016939 is_a: CCO:C0000431 ! kinesin complex [Term] id: CCO:C0000829 name: insulin-like growth factor binding protein complex namespace: cellular_component def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl] subset: goslim_pir synonym: "IGF binding protein complex" EXACT [] xref: GO:0016942 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0000830 name: myosin phosphatase complex namespace: cellular_component def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin." [EC:3.1.3.16] xref: GO:0017023 is_a: CCO:C0000541 ! protein serine/threonine phosphatase complex [Term] id: CCO:C0000831 name: transcriptional repressor complex namespace: cellular_component def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] subset: goslim_pir xref: GO:0017053 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0000832 name: negative cofactor 2 complex namespace: cellular_component def: "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413] xref: GO:0017054 is_a: CCO:C0000831 ! transcriptional repressor complex [Term] id: CCO:C0000833 name: serine C-palmitoyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50] xref: GO:0017059 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0000834 name: intracellular cyclic nucleotide activated cation channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah] xref: GO:0017071 is_a: CCO:C0000767 ! integral to membrane is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000835 name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex namespace: cellular_component def: "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamin diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4] synonym: "BCADH" EXACT [] synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT [] xref: GO:0017086 xref: GO:0031212 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000836 name: mitochondrial processing peptidase complex namespace: cellular_component def: "This enzyme complex catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [EC:3.4.24.64] xref: GO:0017087 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000837 name: meprin A complex namespace: cellular_component def: "An enzyme complex that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18] xref: GO:0017090 is_a: CCO:C0000767 ! integral to membrane is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000838 name: aminoacyl-tRNA synthetase multienzyme complex namespace: cellular_component def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847] synonym: "aminoacyl-tRNA synthetase complex" EXACT [] synonym: "multisynthetase complex" EXACT [] xref: GO:0017101 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000839 name: methionyl glutamyl tRNA synthetase complex namespace: cellular_component def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915] xref: GO:0017102 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000840 name: glutamate-cysteine ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2] xref: GO:0017109 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000841 name: single-stranded DNA-dependent ATP-dependent DNA helicase complex namespace: cellular_component def: "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity." [GOC:mah] xref: GO:0017117 is_a: CCO:C0001555 ! DNA helicase complex [Term] id: CCO:C0000842 name: Golgi transport complex namespace: cellular_component def: "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665] synonym: "COG complex" EXACT [] synonym: "conserved oligomeric Golgi complex" EXACT [] synonym: "Sec34/35 complex" NARROW [] xref: GO:0017119 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001850 ! Golgi apparatus part [Term] id: CCO:C0000843 name: UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase complex namespace: cellular_component def: "Heterotrimeric enzyme complex, which in humans is composed of two large subunits of the same size, and one smaller subunit. Functions in the addition of nucleotide-activated sugars onto the polypeptide." [UniProtKB:O15294] xref: GO:0017122 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000844 name: mitochondrial electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "electron transfer flavoprotein complex (sensu Eukaryota)" EXACT [] xref: GO:0017133 is_a: CCO:C0001848 ! mitochondrial part is_a: CCO:C0001914 ! electron transfer flavoprotein complex relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000845 name: N-methyl-D-aspartate selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] synonym: "NMDA-selective glutamate receptor" EXACT [] xref: GO:0017146 is_a: CCO:C0000545 ! ionotropic glutamate receptor complex [Term] id: CCO:C0000846 name: alpha-glucosidase II complex namespace: cellular_component def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term. xref: GO:0017177 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001851 ! endoplasmic reticulum part [Term] id: CCO:C0000847 name: translation release factor complex namespace: cellular_component def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] synonym: "eukaryotic peptide chain release factor" EXACT [] synonym: "peptide chain release factor" BROAD [] xref: GO:0018444 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000848 name: polar granule namespace: cellular_component def: "A small protein-containing electron dense organelle, not surrounded by a membrane, that induces the formation of and becomes incorporated into germ cells." [GOC:bf, http://cancerweb.ncl.ac.uk/] synonym: "germline granule" EXACT [] synonym: "nuage" BROAD [] xref: GO:0018994 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: part_of CCO:C0001952 ! pole plasm [Term] id: CCO:C0000849 name: host namespace: cellular_component def: "Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "host organism" EXACT [] xref: GO:0018995 is_a: CCO:C0001753 ! extraorganismal space [Term] id: CCO:C0000850 name: SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "CDL1 complex" EXACT [] synonym: "CRL1 complex" EXACT [] synonym: "Cul1-RING ubiquitin ligase complex" EXACT [] synonym: "cullin-RING ligase 1" EXACT [] synonym: "SCF complex" EXACT [] synonym: "SCF complex substrate recognition subunit" NARROW [] synonym: "Skp1/Cul1/F-box protein complex" EXACT [] xref: GO:0019005 is_a: CCO:C0001248 ! cullin-RING ubiquitin ligase complex [Term] id: CCO:C0000851 name: molybdopterin synthase complex namespace: cellular_component def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] subset: gosubset_prok synonym: "molybdopterin converting factor complex" EXACT [] xref: GO:0019008 xref: GO:0019009 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000852 name: virion namespace: cellular_component def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325] subset: goslim_pir synonym: "complete virus particle" EXACT [] xref: GO:0019012 is_a: CCO:C0000200 ! cellular_component [Term] id: CCO:C0000853 name: viral nucleocapsid namespace: cellular_component def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] synonym: "core" BROAD [] synonym: "nucleocapsid" EXACT [] xref: GO:0019013 xref: GO:0019014 is_a: CCO:C0001842 ! virion part relationship: part_of CCO:C0000867 ! viral capsid [Term] id: CCO:C0000854 name: viral genome namespace: cellular_component def: "The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0019015 is_a: CCO:C0001842 ! virion part [Term] id: CCO:C0000855 name: non-segmented viral genome namespace: cellular_component def: "A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk] xref: GO:0019016 is_a: CCO:C0000854 ! viral genome [Term] id: CCO:C0000856 name: segmented viral genome namespace: cellular_component def: "A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336] xref: GO:0019017 is_a: CCO:C0000854 ! viral genome [Term] id: CCO:C0000857 name: bipartite viral genome namespace: cellular_component def: "A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] xref: GO:0019018 is_a: CCO:C0000856 ! segmented viral genome [Term] id: CCO:C0000858 name: tripartite viral genome namespace: cellular_component def: "A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] xref: GO:0019019 is_a: CCO:C0000856 ! segmented viral genome [Term] id: CCO:C0000859 name: multipartite viral genome namespace: cellular_component def: "A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] xref: GO:0019020 is_a: CCO:C0000856 ! segmented viral genome [Term] id: CCO:C0000860 name: DNA viral genome namespace: cellular_component def: "A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336] xref: GO:0019021 is_a: CCO:C0000854 ! viral genome [Term] id: CCO:C0000861 name: RNA viral genome namespace: cellular_component def: "A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336] xref: GO:0019022 is_a: CCO:C0000854 ! viral genome [Term] id: CCO:C0000862 name: dsRNA viral genome namespace: cellular_component def: "A viral genome composed of double stranded RNA." [ISBN:0121585336] xref: GO:0019023 is_a: CCO:C0000861 ! RNA viral genome [Term] id: CCO:C0000863 name: ssRNA viral genome namespace: cellular_component def: "A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336] xref: GO:0019024 is_a: CCO:C0000861 ! RNA viral genome [Term] id: CCO:C0000864 name: positive sense viral genome namespace: cellular_component def: "A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336] xref: GO:0019025 is_a: CCO:C0000863 ! ssRNA viral genome [Term] id: CCO:C0000865 name: negative sense viral genome namespace: cellular_component def: "A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336] xref: GO:0019026 is_a: CCO:C0000863 ! ssRNA viral genome [Term] id: CCO:C0000866 name: ambisense viral genome namespace: cellular_component def: "A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336] xref: GO:0019027 is_a: CCO:C0000863 ! ssRNA viral genome [Term] id: CCO:C0000867 name: viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "viral capsid (sensu Retroviridae)" EXACT [] xref: GO:0019028 xref: GO:0046728 is_a: CCO:C0001842 ! virion part [Term] id: CCO:C0000868 name: helical viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X] xref: GO:0019029 is_a: CCO:C0000867 ! viral capsid [Term] id: CCO:C0000869 name: icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Tobacco satellite necrosis virus has such a capsid structure." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:071673706X] synonym: "quasispherical viral capsid" EXACT [] xref: GO:0019030 is_a: CCO:C0000867 ! viral capsid [Term] id: CCO:C0000870 name: viral envelope namespace: cellular_component def: "The lipid bilayer and associated glycoproteins that surround many types of virus particle." [ISBN:0781718325] synonym: "viral glycoprotein" RELATED [] synonym: "viral membrane" EXACT [] xref: GO:0019031 is_a: CCO:C0001842 ! virion part [Term] id: CCO:C0000871 name: viral tegument namespace: cellular_component def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: GO:0019033 is_a: CCO:C0001842 ! virion part [Term] id: CCO:C0000872 name: viral replication complex namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325] xref: GO:0019034 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000873 name: viral integration complex namespace: cellular_component def: "Virus-specific complex of protein required for integrating viral genomes into the host genome." [ISBN:0781718325] xref: GO:0019035 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000874 name: viral transcriptional complex namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325] xref: GO:0019036 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000875 name: viral assembly intermediate namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325] xref: GO:0019037 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000876 name: provirus namespace: cellular_component def: "The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336] xref: GO:0019038 is_a: CCO:C0000854 ! viral genome is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0000877 name: histamine-gated chloride channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah] xref: GO:0019183 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0000878 name: snRNA-activating protein complex namespace: cellular_component def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788] synonym: "SNAPc" EXACT [] xref: GO:0019185 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0000879 name: phosphoenolpyruvate-dependent sugar phosphotransferase complex namespace: cellular_component def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma] xref: GO:0019197 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000880 name: synaptosome namespace: cellular_component def: "Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. xref: GO:0019717 is_a: CCO:C0000244 ! membrane fraction [Term] id: CCO:C0000881 name: rough microsome namespace: cellular_component def: "Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. xref: GO:0019718 is_a: CCO:C0000373 ! microsome [Term] id: CCO:C0000882 name: smooth microsome namespace: cellular_component def: "Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. xref: GO:0019719 is_a: CCO:C0000373 ! microsome [Term] id: CCO:C0000885 name: quinolinate synthetase complex namespace: cellular_component def: "A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902] comment: See also the molecular function term 'L-aspartate oxidase activity ; GO:0008734'. subset: gosubset_prok xref: GO:0019804 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000886 name: Type I site-specific deoxyribonuclease complex namespace: cellular_component def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748] subset: gosubset_prok synonym: "Type I restriction enzyme complex" EXACT [] xref: GO:0019812 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000887 name: Type III site-specific deoxyribonuclease complex namespace: cellular_component def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] subset: gosubset_prok synonym: "Type III restriction enzyme complex" EXACT [] xref: GO:0019813 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0000888 name: immunoglobulin complex namespace: cellular_component def: "A multiprotein complex that functions as an antibody. Immunoglobulins (Igs) are composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. The classes of Ig are IgA, IgD, IgE, IgG and IgM; they may be embedded in the plasma membrane or circulate in the blood or lymph." [GOC:jl, ISBN:0140512713] subset: goslim_pir xref: GO:0019814 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0000889 name: B cell receptor complex namespace: cellular_component def: "A membrane-bound antigen receptor complex consisting in its basic form of an antigen-binding subunit (the membrane immunoglobulin or mIg), comprised of two identical heavy chains and two identical light chains held together by disulfide bonds, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [ISBN:0781735149 "Fundamental Immunology"] synonym: "B cell receptor accessory molecule complex" RELATED [] synonym: "B lymphocyte receptor complex" EXACT [] synonym: "B-cell receptor complex" EXACT [] synonym: "B-lymphocyte receptor complex" EXACT [] synonym: "BCR" RELATED [] synonym: "immunoglobulin complex, membrane bound" EXACT [] xref: GO:0019815 xref: GO:0042570 is_a: CCO:C0000888 ! immunoglobulin complex is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000186 ! immunological synapse [Term] id: CCO:C0000890 name: P1 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] xref: GO:0019819 is_a: CCO:C0000359 ! peroxisome [Term] id: CCO:C0000891 name: P2 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] xref: GO:0019820 is_a: CCO:C0000359 ! peroxisome [Term] id: CCO:C0000892 name: P3 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] xref: GO:0019821 is_a: CCO:C0000359 ! peroxisome [Term] id: CCO:C0000893 name: P4 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] xref: GO:0019822 is_a: CCO:C0000359 ! peroxisome [Term] id: CCO:C0000894 name: P5 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] xref: GO:0019823 is_a: CCO:C0000359 ! peroxisome [Term] id: CCO:C0000895 name: P6 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'. synonym: "peroxisome vesicle" BROAD [] xref: GO:0019824 is_a: CCO:C0000359 ! peroxisome [Term] id: CCO:C0000896 name: flagellum namespace: cellular_component def: "Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [http://haven.isb-sib.ch/spdocann//dicterms.txt, UniProtKB:kwdictionary] subset: goslim_pir subset: gosubset_prok xref: GO:0008223 xref: GO:0019861 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0000897 name: organelle inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] comment: See also the cellular component term 'outer membrane ; GO:0019867'. subset: gosubset_prok xref: GO:0019866 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0001360 ! organelle envelope [Term] id: CCO:C0000898 name: outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [http://haven.isb-sib.ch/spdocann//dicterms.txt, UniProtKB:kwdictionary] subset: gosubset_prok xref: GO:0019867 is_a: CCO:C0000766 ! membrane [Term] id: CCO:C0000899 name: extrinsic to plasma membrane namespace: cellular_component def: "Loosely bound to one surface of the plasma membrane, but not integrated into the hydrophobic region." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "juxtamembrane" BROAD [] synonym: "peripheral plasma membrane protein" EXACT [] xref: GO:0000157 xref: GO:0019897 is_a: CCO:C0000900 ! extrinsic to membrane is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000900 name: extrinsic to membrane namespace: cellular_component def: "Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/] comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions. subset: gosubset_prok synonym: "peripheral membrane protein" EXACT [] xref: GO:0019898 xref: GO:0030396 is_a: CCO:C0001844 ! membrane part relationship: location_of CCO:B0002064 ! GML_HUMAN [Term] id: CCO:C0000901 name: cyclin-dependent protein kinase activating kinase holoenzyme complex namespace: cellular_component def: "A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor." [GOC:mah, PMID:8752210] synonym: "CAK complex" EXACT [] synonym: "CDK-activating kinase complex" EXACT [] xref: GO:0019907 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part relationship: location_of CCO:B0010998 ! CCNH_HUMAN-Phosphoserine5 [Term] id: CCO:C0000902 name: nuclear cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] xref: GO:0019908 is_a: CCO:C0000053 ! cyclin-dependent protein kinase holoenzyme complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0000903 name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, UniProtKB:P35816] comment: See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'. synonym: "pyruvate dehydrogenase (lipoamide) phosphatase complex (sensu Eukaryota)" EXACT [] xref: GO:0019910 is_a: CCO:C0001848 ! mitochondrial part is_a: CCO:C0001916 ! pyruvate dehydrogenase (lipoamide) phosphatase complex relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000904 name: host cell plasma membrane namespace: cellular_component def: "The plasma membrane surrounding a host cell." [GOC:mb] subset: gosubset_prok xref: GO:0020002 is_a: CCO:C0001589 ! host cell membrane [Term] id: CCO:C0000905 name: parasitophorous vacuole namespace: cellular_component def: "Vacuole within a host cell in which a parasite resides." [GOC:mb] xref: GO:0020003 is_a: CCO:C0000355 ! vacuole is_a: CCO:C0001599 ! host cell cytoplasm part [Term] id: CCO:C0000906 name: parasitophorous vacuolar space namespace: cellular_component def: "Space between a parasite plasma membrane and the parasitophorous vacuolar membrane." [GOC:mb] xref: GO:0020004 is_a: CCO:C0000357 ! vacuolar lumen is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000905 ! parasitophorous vacuole [Term] id: CCO:C0000907 name: parasitophorous vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding a parasitophorous vacuole." [GOC:mb] xref: GO:0020005 is_a: CCO:C0000356 ! vacuolar membrane is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000905 ! parasitophorous vacuole [Term] id: CCO:C0000908 name: parasitophorous vacuolar membrane network namespace: cellular_component def: "Tubular network of extensions from the parasitophorous vacuolar membrane that protrude into the host cytoplasm." [PMID:3528173] synonym: "tubulovesicular network" NARROW [] xref: GO:0020006 is_a: CCO:C0000356 ! vacuolar membrane is_a: CCO:C0001840 ! extracellular region part is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0000907 ! parasitophorous vacuolar membrane [Term] id: CCO:C0000909 name: apical complex namespace: cellular_component def: "Protruding complex at the anterior end of some life cycle stages of all apicomplexan parasites, involved in both the attachment and penetration of the host cell by the parasite." [GOC:mb] xref: GO:0020007 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0001896 ! apical part of cell [Term] id: CCO:C0000910 name: rhoptry namespace: cellular_component def: "A specialized secretory organelle, with a tubular or sacular shape, found in the apical complex." [ISBN:0521664470, PMID:17305424] xref: GO:0020008 is_a: CCO:C0001882 ! cell part is_a: CCO:C0002133 ! extracellular membrane-bounded organelle relationship: part_of CCO:C0000909 ! apical complex [Term] id: CCO:C0000911 name: microneme namespace: cellular_component def: "Elongated tubular organelle arranged longitudinally in the apical complex of an apicomplexan parasite." [ISBN:0521664470] xref: GO:0020009 is_a: CCO:C0002129 ! intracellular membrane-bounded organelle relationship: part_of CCO:C0000909 ! apical complex [Term] id: CCO:C0000912 name: conoid namespace: cellular_component def: "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the comventional tubular structure characteristic of mictotubules." [GOC:expert_dr, PMID:11901169, PMID:16518471] xref: GO:0020010 is_a: CCO:C0000434 ! microtubule relationship: part_of CCO:C0000909 ! apical complex [Term] id: CCO:C0000913 name: apicoplast namespace: cellular_component def: "The plastid organelle found in apicomplexans." [ISBN:0521664470] xref: GO:0020011 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0000914 name: glycosome namespace: cellular_component def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb] subset: goslim_pir xref: GO:0020015 is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0000915 name: flagellar pocket namespace: cellular_component def: "Invagination of the plasma membrane from which a flagellum protrudes." [GOC:mb] xref: GO:0020016 is_a: CCO:C0001861 ! microtubule-based flagellum part [Term] id: CCO:C0000916 name: flagellar membrane namespace: cellular_component def: "The lipid bilayer surrounding the flagellum; continuous with the plasma membrane." [GOC:mb] xref: GO:0020017 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001861 ! microtubule-based flagellum part is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0000917 name: flagellar pocket membrane namespace: cellular_component def: "That part of the plasma membrane found in the flagellar pocket." [GOC:mb] xref: GO:0020018 is_a: CCO:C0000916 ! flagellar membrane relationship: part_of CCO:C0000915 ! flagellar pocket [Term] id: CCO:C0000918 name: food vacuole namespace: cellular_component def: "Vacuole within a parasite used for digestion of the host cell cytoplasm." [GOC:mb] synonym: "digestive vacuole" EXACT [] synonym: "food vacuole (sensu Apicomplexa)" EXACT [] xref: GO:0005772 xref: GO:0020020 is_a: CCO:C0001382 ! phagolysosome [Term] id: CCO:C0000919 name: acidocalcisome namespace: cellular_component def: "An electron-dense acidic organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb] subset: goslim_pir synonym: "metachromatic granule" EXACT [PMID:15738951] synonym: "polyphosphate vacuole" RELATED [PMID:15738951] synonym: "volutin granule" EXACT [PMID:15738951] xref: GO:0020022 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0000920 name: kinetoplast namespace: cellular_component def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb] xref: GO:0020023 is_a: CCO:C0001848 ! mitochondrial part [Term] id: CCO:C0000921 name: subpellicular microtubule namespace: cellular_component def: "Singlet microtubules that lie underneath the inner membrane complex and emanate from the basal ring of the conoid." [GOC:mb] xref: GO:0020025 is_a: CCO:C0000434 ! microtubule relationship: part_of CCO:C0000909 ! apical complex [Term] id: CCO:C0000922 name: merozoite dense granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell." [GOC:mb, GOC:mtg_sensu] synonym: "dense body" EXACT [] synonym: "dense granule (sensu Apicomplexa)" EXACT [] xref: GO:0020026 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0000923 name: infected host cell surface knob namespace: cellular_component def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte." [GOC:mb] synonym: "knob (sensu Plasmodium)" EXACT [] xref: GO:0020030 is_a: CCO:C0001599 ! host cell cytoplasm part [Term] id: CCO:C0000924 name: polar ring of apical complex namespace: cellular_component def: "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mb, PMID:16518471] synonym: "anterior polar ring of apical complex" EXACT [] synonym: "upper polar ring of apical complex" EXACT [] xref: GO:0020031 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0000909 ! apical complex [Term] id: CCO:C0000925 name: basal ring of apical complex namespace: cellular_component def: "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mah, PMID:16518471] synonym: "lower polar ring of apical complex" EXACT [] synonym: "posterior polar ring of apical complex" EXACT [] synonym: "preconoidal ring of apical complex" EXACT [] xref: GO:0020032 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0000909 ! apical complex [Term] id: CCO:C0000926 name: Maurer's cleft namespace: cellular_component def: "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton." [PMID:16705161] xref: GO:0020036 is_a: CCO:C0001599 ! host cell cytoplasm part [Term] id: CCO:C0000927 name: subpellicular network namespace: cellular_component def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112] xref: GO:0020038 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000928 ! pellicle [Term] id: CCO:C0000928 name: pellicle namespace: cellular_component def: "The cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mb] xref: GO:0020039 is_a: CCO:C0001849 ! cytoskeletal part [Term] id: CCO:C0000929 name: TRAPP complex namespace: cellular_component def: "A large complex present on the cis-Golgi that acts prior to SNARE complex assembly to mediate vesicle docking and fusion." [PMID:9564032] synonym: "transport protein particle" EXACT [] xref: GO:0030008 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001850 ! Golgi apparatus part relationship: part_of CCO:C0000380 ! cis-Golgi network [Term] id: CCO:C0000930 name: CCR4-NOT complex namespace: cellular_component def: "A large multimeric transcription factor complex that can regulate transcription positively or negatively; consists of a core complex plus additional proteins; may interact with other proteins to control initiation of transcription. In Saccharomyces the core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p; Caf4p, Caf16p, and several less well characterized proteins." [PMID:11113136] xref: GO:0030014 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0000931 name: CCR4-NOT core complex namespace: cellular_component def: "The core of the CCR4-NOT transcription factor complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p." [PMID:11113136] xref: GO:0030015 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part relationship: part_of CCO:C0000930 ! CCR4-NOT complex [Term] id: CCO:C0000932 name: myofibril namespace: cellular_component def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] synonym: "striated muscle fiber" EXACT [] synonym: "striated muscle fibre" EXACT [] xref: GO:0030016 is_a: CCO:C0001766 ! contractile fiber [Term] id: CCO:C0000933 name: sarcomere namespace: cellular_component def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] xref: GO:0030017 is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0000932 ! myofibril [Term] id: CCO:C0000934 name: Z disc namespace: cellular_component def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] synonym: "Z band" EXACT [] synonym: "Z disk" EXACT [] synonym: "Z line" EXACT [] xref: GO:0030018 is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0001328 ! I band [Term] id: CCO:C0000935 name: lamellipodium namespace: cellular_component def: "A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments." [ISBN:0815316194] xref: GO:0030027 is_a: CCO:C0001706 ! cell projection relationship: location_of CCO:B0001546 ! NDKB_HUMAN relationship: location_of CCO:B0001998 ! Q8TEY4_HUMAN relationship: location_of CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 relationship: part_of CCO:C0001172 ! leading edge [Term] id: CCO:C0000936 name: cell junction namespace: cellular_component def: "A specialized region of connection between two cells or between a cell and the extracellular matrix." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0030054 is_a: CCO:C0001877 ! plasma membrane part relationship: location_of CCO:B0002112 ! PAR6G_HUMAN relationship: location_of CCO:B0002150 ! PAR6A_HUMAN relationship: location_of CCO:B0010926 ! CASL_HUMAN-Phosphotyrosine166 relationship: location_of CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 relationship: location_of CCO:B0026380 ! JUB_HUMAN-Phosphoserine119 [Term] id: CCO:C0000938 name: hemidesmosome namespace: cellular_component def: "Point of contact between the basal surface of epithelial cells and the basal lamina. Morphologically resembles desmosomes; attached to intermediate filaments." [ISBN:0815316208] xref: GO:0030056 is_a: CCO:C0002136 ! cell-substrate junction relationship: part_of CCO:C0000706 ! basal plasma membrane [Term] id: CCO:C0000939 name: desmosome namespace: cellular_component def: "A specialised type of cell junction into which intermediate filaments of adjacent cells are inserted. This type of cell junction is characteristic of epithelia. Desmosomes are particularly conspicuous in tissues such as skin that have to withstand mechanical stress." [GOC:mtg_muscle, ISBN:0815316208] synonym: "macula adherens" EXACT [] synonym: "spot desmosome" EXACT [] xref: GO:0030057 is_a: CCO:C0000463 ! intercellular junction relationship: part_of CCO:C0000743 ! intercalated disc relationship: part_of CCO:C0001769 ! apical junction complex [Term] id: CCO:C0000940 name: mitochondrial crista namespace: cellular_component def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "mitochondrial cristae" EXACT [] xref: GO:0030061 is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0000941 name: mitochondrial tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] synonym: "TCA cycle enzyme complex (sensu Eukaryota)" EXACT [] synonym: "tricarboxylic acid cycle enzyme complex (sensu Eukaryota)" EXACT [] xref: GO:0030062 is_a: CCO:C0001848 ! mitochondrial part is_a: CCO:C0001903 ! tricarboxylic acid cycle enzyme complex relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0000942 name: plasma membrane-derived thylakoid namespace: cellular_component def: "A membraneous cellular structure derived from, but not necessarily continuous with, the plasma membrane. It bears the photosynthetic pigments in photosynthetic bacteria." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "thylakoid (sensu Bacteria)" BROAD [] synonym: "thylakoid (sensu Cyanobacteria)" EXACT [] xref: GO:0030075 is_a: CCO:C0000689 ! thylakoid is_a: CCO:C0001688 ! chromatophore [Term] id: CCO:C0000943 name: light-harvesting complex namespace: cellular_component def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr] subset: goslim_pir subset: gosubset_prok synonym: "antenna complex" RELATED [] xref: GO:0030076 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000944 name: plasma membrane light-harvesting complex namespace: cellular_component def: "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "light-harvesting complex (sensu Gram-negative Bacteria)" EXACT [] synonym: "light-harvesting complex (sensu Proteobacteria)" EXACT [] xref: GO:0030077 is_a: CCO:C0000943 ! light-harvesting complex is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0001688 ! chromatophore [Term] id: CCO:C0000945 name: light-harvesting complex, core complex namespace: cellular_component def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr] subset: gosubset_prok xref: GO:0030078 is_a: CCO:C0000944 ! plasma membrane light-harvesting complex [Term] id: CCO:C0000946 name: light-harvesting complex, peripheral complex namespace: cellular_component def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr] subset: gosubset_prok xref: GO:0030079 is_a: CCO:C0000944 ! plasma membrane light-harvesting complex [Term] id: CCO:C0000947 name: B875 antenna complex namespace: cellular_component def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd] subset: gosubset_prok synonym: "LH1 complex" EXACT [] synonym: "light harvesting complex I" EXACT [] xref: GO:0030080 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0000945 ! light-harvesting complex, core complex [Term] id: CCO:C0000948 name: B800-820 antenna complex namespace: cellular_component def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] subset: gosubset_prok synonym: "LH3 complex" EXACT [] synonym: "light harvesting complex III" EXACT [] xref: GO:0030081 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0000946 ! light-harvesting complex, peripheral complex [Term] id: CCO:C0000949 name: B800-850 antenna complex namespace: cellular_component def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] subset: gosubset_prok synonym: "LH2 complex" EXACT [] synonym: "light harvesting complex II" EXACT [] xref: GO:0030082 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0000946 ! light-harvesting complex, peripheral complex [Term] id: CCO:C0000950 name: PSI associated light-harvesting complex I, LHCIa subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475] xref: GO:0030083 is_a: CCO:C0000647 ! PSI associated light-harvesting complex I [Term] id: CCO:C0000951 name: PSI associated light-harvesting complex I, LHCIb subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475] xref: GO:0030084 is_a: CCO:C0000647 ! PSI associated light-harvesting complex I [Term] id: CCO:C0000952 name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475] xref: GO:0030085 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0000692 ! PSII associated light-harvesting complex II, peripheral complex [Term] id: CCO:C0000953 name: phycobilisome namespace: cellular_component def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0030089 is_a: CCO:C0000943 ! light-harvesting complex is_a: CCO:C0001852 ! cytoplasmic vesicle part is_a: CCO:C0001854 ! plastid part is_a: CCO:C0001855 ! thylakoid part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000701 ! cyanelle thylakoid relationship: part_of CCO:C0000942 ! plasma membrane-derived thylakoid [Term] id: CCO:C0000955 name: chloroplast photosystem I namespace: cellular_component def: "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin." [GOC:jic, GOC:mtg_sensu] synonym: "photosystem I (sensu Magnoliophyta)" EXACT [] xref: GO:0030093 is_a: CCO:C0000650 ! photosystem I is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0000663 ! chloroplast thylakoid membrane [Term] id: CCO:C0000956 name: plasma membrane-derived photosystem I namespace: cellular_component def: "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin." [GOC:jic, GOC:mtg_sensu] subset: gosubset_prok synonym: "photosystem I (sensu Cyanobacteria)" EXACT [] synonym: "plasma membrane photosystem I" EXACT [] xref: GO:0030094 is_a: CCO:C0000650 ! photosystem I is_a: CCO:C0001852 ! cytoplasmic vesicle part is_a: CCO:C0001854 ! plastid part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000942 ! plasma membrane-derived thylakoid [Term] id: CCO:C0000957 name: chloroplast photosystem II namespace: cellular_component def: "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jic, GOC:mtg_sensu] synonym: "photosystem II (sensu Viridiplantae)" EXACT [] xref: GO:0030095 is_a: CCO:C0000651 ! photosystem II is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0000663 ! chloroplast thylakoid membrane [Term] id: CCO:C0000958 name: plasma membrane-derived thylakoid photosystem II namespace: cellular_component def: "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jic, GOC:mtg_sensu] subset: gosubset_prok synonym: "photosystem II (sensu Cyanobacteria)" EXACT [] synonym: "plasma membrane photosystem II" EXACT [] xref: GO:0030096 is_a: CCO:C0000651 ! photosystem II is_a: CCO:C0001852 ! cytoplasmic vesicle part is_a: CCO:C0001854 ! plastid part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000942 ! plasma membrane-derived thylakoid [Term] id: CCO:C0000959 name: glycocalyx namespace: cellular_component def: "A viscous, carbohydrate rich layer at the outermost periphery of a cell." [GOC:mlg, ISBN:0815316208] subset: goslim_pir subset: gosubset_prok xref: GO:0030112 is_a: CCO:C0000999 ! external encapsulating structure [Term] id: CCO:C0000960 name: slime layer namespace: cellular_component def: "A Slime layer is an easily removed, diffuse, unorganised layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, http://www.wikipedia.org/] xref: GO:0030114 is_a: CCO:C0000959 ! glycocalyx [Term] id: CCO:C0000961 name: S-layer namespace: cellular_component def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893] subset: goslim_pir subset: gosubset_prok xref: GO:0030115 is_a: CCO:C0000999 ! external encapsulating structure [Term] id: CCO:C0000962 name: membrane coat namespace: cellular_component def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] xref: GO:0030117 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001997 ! coated membrane [Term] id: CCO:C0000963 name: clathrin coat namespace: cellular_component def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549] synonym: "clathrin cage" EXACT [] xref: GO:0016190 xref: GO:0030118 is_a: CCO:C0000962 ! membrane coat [Term] id: CCO:C0000964 name: AP-type membrane coat adaptor complex namespace: cellular_component def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838] subset: goslim_pir synonym: "clathrin adaptor" RELATED [] xref: GO:0030119 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000962 ! membrane coat [Term] id: CCO:C0000965 name: vesicle coat namespace: cellular_component def: "A membrane coat found on a coated vesicle." [GOC:mah] xref: GO:0030120 is_a: CCO:C0000962 ! membrane coat is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0001027 ! coated vesicle membrane [Term] id: CCO:C0000966 name: AP-1 adaptor complex namespace: cellular_component def: "An AP-type membrane coat adaptor complex that consists of beta1, gamma1, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network." [GOC:mah, PMID:10611976] synonym: "HA1" EXACT [] synonym: "HA1 clathrin adaptor" EXACT [] xref: GO:0030121 is_a: CCO:C0000976 ! clathrin adaptor complex is_a: CCO:C0001850 ! Golgi apparatus part is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0000975 ! clathrin coat of trans-Golgi network vesicle [Term] id: CCO:C0000967 name: AP-2 adaptor complex namespace: cellular_component def: "An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles." [GOC:mah, PMID:10611976] synonym: "HA2" EXACT [] synonym: "HA2 clathrin adaptor" EXACT [] xref: GO:0030122 is_a: CCO:C0000976 ! clathrin adaptor complex is_a: CCO:C0001852 ! cytoplasmic vesicle part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000973 ! clathrin coat of endocytic vesicle relationship: part_of CCO:C0000977 ! clathrin coat of coated pit [Term] id: CCO:C0000968 name: AP-3 adaptor complex namespace: cellular_component def: "An AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes; it is not clear whether AP-3 forms clathrin coats in vivo." [GOC:mah, PMID:10611976] xref: GO:0030123 is_a: CCO:C0000964 ! AP-type membrane coat adaptor complex [Term] id: CCO:C0000969 name: AP-4 adaptor complex namespace: cellular_component def: "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976] xref: GO:0030124 is_a: CCO:C0000964 ! AP-type membrane coat adaptor complex [Term] id: CCO:C0000970 name: clathrin vesicle coat namespace: cellular_component def: "A clathrin coat found on a vesicle." [GOC:mah] xref: GO:0030125 is_a: CCO:C0000963 ! clathrin coat is_a: CCO:C0000965 ! vesicle coat relationship: part_of CCO:C0001029 ! clathrin coated vesicle membrane [Term] id: CCO:C0000971 name: COPI vesicle coat namespace: cellular_component def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] synonym: "coatomer" EXACT [] xref: GO:0017167 xref: GO:0030126 is_a: CCO:C0000965 ! vesicle coat is_a: CCO:C0001850 ! Golgi apparatus part relationship: part_of CCO:C0001028 ! COPI coated vesicle membrane [Term] id: CCO:C0000972 name: COPII vesicle coat namespace: cellular_component def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:mah, PMID:11252894] xref: GO:0030127 is_a: CCO:C0000965 ! vesicle coat is_a: CCO:C0001850 ! Golgi apparatus part relationship: part_of CCO:C0000735 ! ER to Golgi transport vesicle membrane [Term] id: CCO:C0000973 name: clathrin coat of endocytic vesicle namespace: cellular_component def: "A clathrin coat found on an endocytic vesicle." [GOC:mah] synonym: "clathrin coat of endocytotic vesicle" EXACT [] xref: GO:0030128 is_a: CCO:C0000970 ! clathrin vesicle coat relationship: part_of CCO:C0001033 ! clathrin-coated endocytic vesicle membrane [Term] id: CCO:C0000974 name: clathrin coat of synaptic vesicle namespace: cellular_component def: "A clathrin coat found on a synaptic vesicle." [GOC:mah] xref: GO:0030129 is_a: CCO:C0000970 ! clathrin vesicle coat relationship: part_of CCO:C0001036 ! synaptic vesicle membrane [Term] id: CCO:C0000975 name: clathrin coat of trans-Golgi network vesicle namespace: cellular_component def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] synonym: "clathrin coat of TGN vesicle" EXACT [] xref: GO:0030130 is_a: CCO:C0000970 ! clathrin vesicle coat is_a: CCO:C0001850 ! Golgi apparatus part relationship: part_of CCO:C0000738 ! trans-Golgi network transport vesicle membrane [Term] id: CCO:C0000976 name: clathrin adaptor complex namespace: cellular_component def: "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] xref: GO:0030131 is_a: CCO:C0000964 ! AP-type membrane coat adaptor complex relationship: part_of CCO:C0000963 ! clathrin coat [Term] id: CCO:C0000977 name: clathrin coat of coated pit namespace: cellular_component def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah] xref: GO:0030132 is_a: CCO:C0000963 ! clathrin coat is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000462 ! coated pit [Term] id: CCO:C0000978 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, and to destinations within or outside the cell." [GOC:mah] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "Golgi to plasma membrane transport vesicle" NARROW [] synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-plasma membrane transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" BROAD [] xref: GO:0030133 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0000979 name: ER to Golgi transport vesicle namespace: cellular_component def: "A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport." [GOC:mah, PMID:11252894] synonym: "COPII vesicle" RELATED [] synonym: "COPII-coated vesicle" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle" EXACT [] synonym: "endoplasmic reticulum-Golgi transport vesicle" EXACT [] synonym: "ER-Golgi transport vesicle" EXACT [] xref: GO:0030134 xref: GO:0030138 is_a: CCO:C0000379 ! Golgi-associated vesicle is_a: CCO:C0000978 ! transport vesicle is_a: CCO:C0000980 ! coated vesicle [Term] id: CCO:C0000980 name: coated vesicle namespace: cellular_component def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] xref: GO:0005909 xref: GO:0030135 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0000981 name: clathrin-coated vesicle namespace: cellular_component def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] xref: GO:0030136 is_a: CCO:C0000980 ! coated vesicle [Term] id: CCO:C0000982 name: COPI-coated vesicle namespace: cellular_component def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894] synonym: "coatomer" RELATED [] xref: GO:0030137 is_a: CCO:C0000379 ! Golgi-associated vesicle is_a: CCO:C0000980 ! coated vesicle [Term] id: CCO:C0000983 name: endocytic vesicle namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators] subset: gosubset_prok synonym: "endocytotic transport vesicle" EXACT [] synonym: "endocytotic vesicle" EXACT [] xref: GO:0030139 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0000984 name: trans-Golgi network transport vesicle namespace: cellular_component def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] synonym: "TGN transport vesicle" EXACT [] xref: GO:0030140 is_a: CCO:C0000379 ! Golgi-associated vesicle is_a: CCO:C0000978 ! transport vesicle is_a: CCO:C0000981 ! clathrin-coated vesicle [Term] id: CCO:C0000985 name: secretory granule namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. synonym: "secretory vesicle" BROAD [] xref: GO:0030141 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle relationship: location_of CCO:B0010859 ! BRCA2_HUMAN-Phosphoserine683 [Term] id: CCO:C0000986 name: Golgi to ER transport vesicle namespace: cellular_component def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah] synonym: "Golgi to endoplasmic reticulum transport vesicle" EXACT [] synonym: "Golgi-endoplasmic reticulum transport vesicle" EXACT [] synonym: "Golgi-ER transport vesicle" EXACT [] xref: GO:0030142 is_a: CCO:C0000978 ! transport vesicle is_a: CCO:C0000982 ! COPI-coated vesicle [Term] id: CCO:C0000987 name: inter-Golgi transport vesicle namespace: cellular_component def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah] xref: GO:0005807 xref: GO:0030143 is_a: CCO:C0000978 ! transport vesicle is_a: CCO:C0000982 ! COPI-coated vesicle [Term] id: CCO:C0000988 name: integral to Golgi membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] synonym: "Golgi integral membrane protein" RELATED [] xref: GO:0030173 is_a: CCO:C0001152 ! intrinsic to Golgi membrane is_a: CCO:C0001188 ! integral to organelle membrane [Term] id: CCO:C0000989 name: filopodium namespace: cellular_component def: "Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "microspike" EXACT [] xref: GO:0030028 xref: GO:0030175 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0000990 name: integral to endoplasmic reticulum membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] synonym: "ER integral membrane protein" EXACT [] synonym: "integral to ER membrane" EXACT [] xref: GO:0030176 is_a: CCO:C0001151 ! intrinsic to endoplasmic reticulum membrane is_a: CCO:C0001188 ! integral to organelle membrane relationship: location_of CCO:B0001428 ! ERN1_HUMAN [Term] id: CCO:C0000991 name: insulin control element activator complex namespace: cellular_component def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390] synonym: "ICE activator complex" EXACT [] xref: GO:0030232 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0000992 name: type I protein secretion system complex namespace: cellular_component def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447] subset: gosubset_prok synonym: "ABC translocator complex" BROAD [] xref: GO:0030256 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000993 name: type III protein secretion system complex namespace: cellular_component def: "A complex of approximately 20 proteins, most of which are located in the inner membrane that carries out protein secretion in the type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447] subset: gosubset_prok synonym: "T3SS complex" EXACT [] synonym: "TTSS complex" EXACT [] xref: GO:0030257 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0000994 name: integral to synaptic vesicle membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] xref: GO:0030285 is_a: CCO:C0000767 ! integral to membrane is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0001036 ! synaptic vesicle membrane [Term] id: CCO:C0000995 name: dynein complex namespace: cellular_component def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] xref: GO:0030286 is_a: CCO:C0000435 ! microtubule associated complex relationship: location_of CCO:B0011452 ! DCTN1_HUMAN-Phosphoserine541 [Term] id: CCO:C0000996 name: cell wall-bounded periplasmic space namespace: cellular_component def: "The region between the plasma membrane and the cell wall as found in organisms such as yeast and Gram positive bacteria. These periplasmic spaces are quite thin." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "cell wall bounded periplasmic space" EXACT [] synonym: "cell wall-enclosed periplasmic space" EXACT [] synonym: "periplasmic space (sensu Fungi)" NARROW [] xref: GO:0030287 is_a: CCO:C0001662 ! periplasmic space [Term] id: CCO:C0000997 name: outer membrane-bounded periplasmic space namespace: cellular_component def: "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "outer membrane bounded periplasmic space" EXACT [] synonym: "outer membrane-enclosed periplasmic space" EXACT [] synonym: "periplasmic space (sensu Gram-negative Bacteria)" EXACT [] synonym: "periplasmic space (sensu Proteobacteria)" EXACT [] xref: GO:0030288 is_a: CCO:C0001662 ! periplasmic space is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0001000 ! cell envelope [Term] id: CCO:C0000998 name: protein phosphatase 4 complex namespace: cellular_component def: "The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit." [PMID:10026142] xref: GO:0030289 is_a: CCO:C0000541 ! protein serine/threonine phosphatase complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0000999 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:go_curators] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: GO:0030312 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001000 name: cell envelope namespace: cellular_component def: "Everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl, http://pathmicro.med.sc.edu/fox/cell_envelope.htm] subset: goslim_generic subset: goslim_pir subset: gosubset_prok xref: GO:0030313 is_a: CCO:C0000999 ! external encapsulating structure is_a: CCO:C0001367 ! envelope [Term] id: CCO:C0001001 name: junctional membrane complex namespace: cellular_component def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622] synonym: "triad junction" BROAD [] xref: GO:0030314 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000801 ! sarcoplasm [Term] id: CCO:C0001002 name: T-tubule namespace: cellular_component def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194] synonym: "transverse tubule" EXACT [] synonym: "triad" RELATED [] xref: GO:0030315 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0001638 ! sarcolemma [Term] id: CCO:C0001003 name: ferredoxin:thioredoxin reductase complex namespace: cellular_component def: "Complex that possesses ferredoxin:thioredoxin reductase activity." [GOC:mah] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin:thioredoxin reductase activity ; GO:0030385'. xref: GO:0030386 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0001004 name: axon namespace: cellular_component def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0030424 is_a: CCO:C0001707 ! neuron projection relationship: location_of CCO:B0001802 ! CD5R1_HUMAN relationship: location_of CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 [Term] id: CCO:C0001005 name: dendrite namespace: cellular_component def: "A branching protoplasmic process of a neuron that receive and integrate signals coming from axons of other neurons, and convey the resulting signal to the body of the cell." [GOC:nln, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0030425 is_a: CCO:C0001707 ! neuron projection relationship: location_of CCO:B0001802 ! CD5R1_HUMAN relationship: location_of CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 [Term] id: CCO:C0001006 name: growth cone namespace: cellular_component def: "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] xref: GO:0030426 is_a: CCO:C0001007 ! site of polarized growth relationship: location_of CCO:B0001802 ! CD5R1_HUMAN relationship: location_of CCO:B0001998 ! Q8TEY4_HUMAN relationship: location_of CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 [Term] id: CCO:C0001007 name: site of polarized growth namespace: cellular_component def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah] subset: goslim_candida subset: goslim_pir subset: goslim_yeast synonym: "site of polarized growth (sensu Fungi)" EXACT [] synonym: "site of polarized growth (sensu Saccharomyces)" EXACT [] xref: GO:0000134 xref: GO:0030427 xref: GO:0030483 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001008 name: cell septum namespace: cellular_component def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526] subset: goslim_pir subset: gosubset_prok synonym: "cross wall" EXACT [] synonym: "septum" BROAD [] xref: GO:0030428 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001009 name: host cell cytoplasm namespace: cellular_component def: "The cytoplasm of a host cell." [GOC:mah] subset: gosubset_prok xref: GO:0030430 is_a: CCO:C0001591 ! host intracellular part relationship: part_of CCO:C0001803 ! intracellular region of host [Term] id: CCO:C0001010 name: yeast-form cell wall namespace: cellular_component def: "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc] comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'. xref: GO:0030445 is_a: CCO:C0002066 ! fungal-type cell wall [Term] id: CCO:C0001011 name: hyphal cell wall namespace: cellular_component def: "The cell wall surrounding a fungal hypha." [GOC:mah] comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'. xref: GO:0030446 is_a: CCO:C0002066 ! fungal-type cell wall [Term] id: CCO:C0001012 name: actin cap namespace: cellular_component def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell." [GOC:mah, ISBN:10652251] synonym: "actin cap (sensu Fungi)" EXACT [] synonym: "actin cap (sensu Saccharomyces)" NARROW [] xref: GO:0000143 xref: GO:0030478 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001867 ! cell cortex part relationship: part_of CCO:C0001056 ! cortical actin cytoskeleton [Term] id: CCO:C0001013 name: actin cortical patch namespace: cellular_component def: "Discrete actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mah, ISBN:0879693568, ISBN:0879693649, Sanger:wv] synonym: "actin cortical patch (sensu Fungi)" EXACT [] synonym: "actin cortical patch (sensu Saccharomyces)" NARROW [] synonym: "actin patch" EXACT [] xref: GO:0005857 xref: GO:0030479 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001867 ! cell cortex part relationship: part_of CCO:C0001056 ! cortical actin cytoskeleton [Term] id: CCO:C0001014 name: actin cable namespace: cellular_component def: "A long bundle of actin filaments, comprising filamentous actin and associated proteins, found in cells." [ISBN:0879693649] synonym: "actin cable (sensu Fungi)" EXACT [] synonym: "actin cable (sensu Saccharomyces)" EXACT [] xref: GO:0000141 xref: GO:0030482 is_a: CCO:C0001449 ! actin filament bundle [Term] id: CCO:C0001015 name: smooth muscle contractile fiber namespace: cellular_component def: "The contractile fiber of smooth muscle cells." [GOC:mah] synonym: "smooth muscle fiber" BROAD [] synonym: "smooth muscle fibre" EXACT [] xref: GO:0030485 is_a: CCO:C0001766 ! contractile fiber is_a: CCO:C0001868 ! contractile fiber part [Term] id: CCO:C0001016 name: smooth muscle dense body namespace: cellular_component def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194] xref: GO:0030486 is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0001015 ! smooth muscle contractile fiber [Term] id: CCO:C0001017 name: midbody namespace: cellular_component def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] subset: goslim_pir xref: GO:0030496 is_a: CCO:C0001882 ! cell part relationship: location_of CCO:B0036017 ! MYH10_HUMAN-Phosphothreonine1376 [Term] id: CCO:C0001018 name: granulocyte macrophage colony-stimulating factor receptor complex namespace: cellular_component def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah] xref: GO:0030526 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001019 name: ribonucleoprotein complex namespace: cellular_component def: "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] subset: goslim_pir subset: gosubset_prok synonym: "protein-RNA complex" EXACT [] synonym: "ribonucleoprotein" EXACT [] synonym: "RNA-protein complex" EXACT [] synonym: "RNP" EXACT [] xref: GO:0030529 is_a: CCO:C0001492 ! macromolecular complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001020 name: heterogeneous nuclear ribonucleoprotein complex namespace: cellular_component def: "Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "heterogeneous nuclear ribonucleoprotein" EXACT [] synonym: "hnRNP" EXACT [] xref: GO:0030530 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001021 name: small cytoplasmic ribonucleoprotein complex namespace: cellular_component def: "A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah] synonym: "scRNP" EXACT [] synonym: "small cytoplasmic ribonucleoprotein" EXACT [] xref: GO:0030531 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001022 name: small nuclear ribonucleoprotein complex namespace: cellular_component def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] subset: goslim_pir synonym: "small nuclear ribonucleoprotein" EXACT [] synonym: "snRNP" EXACT [] xref: GO:0030532 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001023 name: transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] xref: GO:0030658 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0000978 ! transport vesicle [Term] id: CCO:C0001024 name: cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] xref: GO:0030659 is_a: CCO:C0000734 ! vesicle membrane is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0001025 name: Golgi-associated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] synonym: "Golgi vesicle membrane" RELATED [] xref: GO:0030660 is_a: CCO:C0000021 ! Golgi membrane is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0000379 ! Golgi-associated vesicle [Term] id: CCO:C0001026 name: chitosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a chitosome." [GOC:mah] xref: GO:0030661 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0001883 ! chitosome [Term] id: CCO:C0001027 name: coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah] xref: GO:0030662 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0000980 ! coated vesicle [Term] id: CCO:C0001028 name: COPI coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah] xref: GO:0030663 is_a: CCO:C0001027 ! coated vesicle membrane is_a: CCO:C0001850 ! Golgi apparatus part relationship: part_of CCO:C0000982 ! COPI-coated vesicle [Term] id: CCO:C0001029 name: clathrin coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah] xref: GO:0030665 is_a: CCO:C0001027 ! coated vesicle membrane relationship: part_of CCO:C0000981 ! clathrin-coated vesicle [Term] id: CCO:C0001030 name: endocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah] xref: GO:0030666 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0000983 ! endocytic vesicle [Term] id: CCO:C0001031 name: secretory granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] xref: GO:0030667 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0000985 ! secretory granule [Term] id: CCO:C0001032 name: merozoite dense granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu] synonym: "dense granule membrane (sensu Apicomplexa)" EXACT [] xref: GO:0030668 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0000922 ! merozoite dense granule [Term] id: CCO:C0001033 name: clathrin-coated endocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah] xref: GO:0030669 is_a: CCO:C0001029 ! clathrin coated vesicle membrane is_a: CCO:C0001030 ! endocytic vesicle membrane relationship: part_of CCO:C0001949 ! clathrin-coated endocytic vesicle [Term] id: CCO:C0001034 name: phagocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah] xref: GO:0030670 is_a: CCO:C0001030 ! endocytic vesicle membrane relationship: part_of CCO:C0001950 ! phagocytic vesicle [Term] id: CCO:C0001035 name: clathrin-coated phagocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah] xref: GO:0030671 is_a: CCO:C0001033 ! clathrin-coated endocytic vesicle membrane is_a: CCO:C0001034 ! phagocytic vesicle membrane relationship: part_of CCO:C0001951 ! clathrin-coated phagocytic vesicle [Term] id: CCO:C0001036 name: synaptic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah] xref: GO:0030672 is_a: CCO:C0000734 ! vesicle membrane is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0000522 ! synaptic vesicle [Term] id: CCO:C0001037 name: axolemma namespace: cellular_component def: "The plasma membrane of an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653] xref: GO:0030673 is_a: CCO:C0000766 ! membrane is_a: CCO:C0001469 ! neuron projection membrane is_a: CCO:C0001562 ! axon part [Term] id: CCO:C0001038 name: ribonuclease P complex namespace: cellular_component def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094] comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA. subset: goslim_pir subset: gosubset_prok synonym: "RNase P complex" EXACT [] xref: GO:0030677 is_a: CCO:C0001019 ! ribonucleoprotein complex [Term] id: CCO:C0001039 name: mitochondrial ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094] synonym: "mitochondrial RNase P complex" EXACT [] xref: GO:0030678 is_a: CCO:C0001038 ! ribonuclease P complex is_a: CCO:C0001848 ! mitochondrial part [Term] id: CCO:C0001040 name: cyanelle ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] synonym: "cyanelle RNase P complex" EXACT [] xref: GO:0030679 is_a: CCO:C0001042 ! multimeric ribonuclease P complex is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000700 ! cyanelle [Term] id: CCO:C0001041 name: dimeric ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule." [GOC:mah, PMID:12045094] subset: gosubset_prok synonym: "dimeric RNase P complex" EXACT [] synonym: "ribonuclease P complex (sensu Bacteria)" NARROW [] synonym: "RNase P complex (sensu Bacteria)" NARROW [] xref: GO:0030680 is_a: CCO:C0001038 ! ribonuclease P complex [Term] id: CCO:C0001042 name: multimeric ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules." [GOC:mah, PMID:11142368, PMID:12045094] synonym: "multimeric RNase P complex" EXACT [] synonym: "ribonuclease P complex (sensu Archaea" NARROW [] synonym: "RNase P complex (sensu Archaea)" NARROW [] xref: GO:0030681 is_a: CCO:C0001038 ! ribonuclease P complex [Term] id: CCO:C0001043 name: preribosome namespace: cellular_component def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] subset: goslim_pir xref: GO:0030684 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001044 name: nucleolar preribosome namespace: cellular_component def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516] xref: GO:0030685 is_a: CCO:C0001043 ! preribosome is_a: CCO:C0001871 ! nucleolar part [Term] id: CCO:C0001045 name: 90S preribosome namespace: cellular_component def: "A preribosomal complex consisting of the 35S pre-rRNA, the 5S rRNA, early-associating ribosomal proteins, and associated proteins." [PMID:10567516] xref: GO:0030686 is_a: CCO:C0001044 ! nucleolar preribosome [Term] id: CCO:C0001046 name: nucleolar preribosome, large subunit precursor namespace: cellular_component def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516] comment: Note that this complex is 66S in Saccharomyces. synonym: "66S preribosome" NARROW [] xref: GO:0030687 is_a: CCO:C0001044 ! nucleolar preribosome [Term] id: CCO:C0001047 name: nucleolar preribosome, small subunit precursor namespace: cellular_component def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516] comment: Note that this complex is 43S in Saccharomyces. synonym: "43S preribosome" NARROW [] xref: GO:0030688 is_a: CCO:C0001044 ! nucleolar preribosome [Term] id: CCO:C0001048 name: Noc complex namespace: cellular_component def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671] comment: Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found. subset: goslim_pir xref: GO:0030689 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001049 name: Noc1p-Noc2p complex namespace: cellular_component def: "A heterodimer associated with 90S and 66S preribosomes in the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. xref: GO:0030690 is_a: CCO:C0001048 ! Noc complex is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001871 ! nucleolar part relationship: part_of CCO:C0001045 ! 90S preribosome relationship: part_of CCO:C0001046 ! nucleolar preribosome, large subunit precursor [Term] id: CCO:C0001050 name: Noc2p-Noc3p complex namespace: cellular_component def: "A heterodimer associated with 66S preribosomes; also found throughout the nucleoplasm; involved in ribosomal large subunit biogenesis." [PMID:12446671] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. xref: GO:0030691 is_a: CCO:C0001048 ! Noc complex is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001870 ! nucleoplasm part is_a: CCO:C0001871 ! nucleolar part relationship: part_of CCO:C0001046 ! nucleolar preribosome, large subunit precursor [Term] id: CCO:C0001051 name: Noc4p-Nop14p complex namespace: cellular_component def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. xref: GO:0030692 is_a: CCO:C0001048 ! Noc complex is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001871 ! nucleolar part relationship: part_of CCO:C0001045 ! 90S preribosome relationship: part_of CCO:C0001047 ! nucleolar preribosome, small subunit precursor [Term] id: CCO:C0001053 name: glycine reductase complex namespace: cellular_component def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'. subset: gosubset_prok xref: GO:0030700 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001054 name: autosome namespace: cellular_component def: "Any chromosome other than a sex chromosome." [GOC:mah] comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism. xref: GO:0030849 is_a: CCO:C0000296 ! chromosome [Term] id: CCO:C0001055 name: cortical cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] xref: GO:0030863 is_a: CCO:C0000421 ! cytoskeleton is_a: CCO:C0001867 ! cell cortex part [Term] id: CCO:C0001056 name: cortical actin cytoskeleton namespace: cellular_component def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] xref: GO:0030864 is_a: CCO:C0001055 ! cortical cytoskeleton is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0001057 name: rough endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah] synonym: "rough ER membrane" EXACT [] xref: GO:0030867 is_a: CCO:C0000370 ! endoplasmic reticulum membrane relationship: part_of CCO:C0000372 ! rough endoplasmic reticulum [Term] id: CCO:C0001058 name: smooth endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah] synonym: "smooth ER membrane" EXACT [] xref: GO:0030868 is_a: CCO:C0000370 ! endoplasmic reticulum membrane relationship: part_of CCO:C0000371 ! smooth endoplasmic reticulum [Term] id: CCO:C0001059 name: RENT complex namespace: cellular_component def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389] xref: GO:0030869 is_a: CCO:C0000280 ! chromatin silencing complex [Term] id: CCO:C0001060 name: Mre11 complex namespace: cellular_component def: "Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [GOC:mah, PMID:11988766] synonym: "MRN complex" EXACT [] synonym: "MRX complex" EXACT [] synonym: "Rad50 complex" EXACT [] synonym: "Rad50-Rad32-Nbs1 complex" EXACT [] synonym: "RMX complex" EXACT [] xref: GO:0030870 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001064 name: nucleolar chromatin namespace: cellular_component def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah] xref: GO:0030874 is_a: CCO:C0001871 ! nucleolar part is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000117 ! nuclear chromatin [Term] id: CCO:C0001065 name: rDNA protrusion namespace: cellular_component def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244] comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern. synonym: "ribosomal DNA protrusion" EXACT [] xref: GO:0030875 is_a: CCO:C0001871 ! nucleolar part is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0001064 ! nucleolar chromatin [Term] id: CCO:C0001066 name: interleukin-20 receptor complex namespace: cellular_component def: "Complex that binds interleukin-20; comprises an alpha and a beta subunit." [GOC:mah] xref: GO:0030876 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001067 name: beta-catenin destruction complex namespace: cellular_component def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] synonym: "beta-catenin degradation complex" EXACT [] xref: GO:0030877 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part relationship: location_of CCO:B0010567 ! APC_HUMAN-Phosphoserine1038 [Term] id: CCO:C0001068 name: RNA polymerase complex namespace: cellular_component def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] subset: goslim_pir subset: gosubset_prok xref: GO:0030880 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001069 name: VCB complex namespace: cellular_component def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071] synonym: "pVHL-elongin C-elongin B complex" EXACT [] synonym: "VHL complex" EXACT [] synonym: "von Hippel-Lindau tumor suppressor complex" EXACT [] xref: GO:0030891 is_a: CCO:C0000028 ! cytoplasmic ubiquitin ligase complex [Term] id: CCO:C0001070 name: mitotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522] xref: GO:0030892 is_a: CCO:C0000538 ! cohesin complex [Term] id: CCO:C0001071 name: meiotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522] xref: GO:0030893 is_a: CCO:C0000538 ! cohesin complex [Term] id: CCO:C0001072 name: replisome namespace: cellular_component def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] subset: goslim_pir subset: gosubset_prok xref: GO:0030894 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000265 ! replication fork [Term] id: CCO:C0001073 name: apolipoprotein B mRNA editing enzyme complex namespace: cellular_component def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591] synonym: "apoB mRNA editing enzyme complex" EXACT [] synonym: "APOBEC" EXACT [] xref: GO:0030895 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001074 name: checkpoint clamp complex namespace: cellular_component def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008] comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p. synonym: "CCC" EXACT [] synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" EXACT [] xref: GO:0030896 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000121 ! condensed nuclear chromosome [Term] id: CCO:C0001075 name: HOPS complex namespace: cellular_component def: "A multimeric protein complex that associates with the vacuolar membrane and is involved in homotypic vacuole fusion and vacuole protein sorting. For example, the Saccharomyces complex contains Vps41p, Vam6p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:10944212] xref: GO:0030897 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001856 ! vacuolar part relationship: part_of CCO:C0000356 ! vacuolar membrane [Term] id: CCO:C0001076 name: retromer complex namespace: cellular_component def: "A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p." [PMID:9700157] subset: goslim_pir xref: GO:0030904 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0000733 ! endomembrane system [Term] id: CCO:C0001077 name: retromer complex, outer shell namespace: cellular_component def: "One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer." [PMID:9700157] xref: GO:0030905 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0001076 ! retromer complex [Term] id: CCO:C0001078 name: retromer complex, inner shell namespace: cellular_component def: "One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p." [PMID:9700157] xref: GO:0030906 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0001076 ! retromer complex [Term] id: CCO:C0001079 name: MBF transcription complex namespace: cellular_component def: "A complex of two or three proteins that binds to the Mlu1 cell cycle box (MCB) promoter element and is involved in cell cycle-dependent regulation of transcription. In Saccharomyces the complex consists of Mbp1p and Swi6p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [PMID:9343385] synonym: "DSC1 transcription factor complex" EXACT [] synonym: "MBF" EXACT [] synonym: "Mlu1-box binding factor" EXACT [] xref: GO:0030907 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0001080 name: STAGA complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs." [PMID:11564863] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. xref: GO:0030914 is_a: CCO:C0000011 ! histone acetyltransferase complex [Term] id: CCO:C0001081 name: Smc5-Smc6 complex namespace: cellular_component def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S.cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739] xref: GO:0030915 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000120 ! condensed chromosome [Term] id: CCO:C0001082 name: ADPG pyrophosphorylase complex namespace: cellular_component def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965] subset: goslim_pir subset: gosubset_prok xref: GO:0030929 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001083 name: homotetrameric ADPG pyrophosphorylase complex namespace: cellular_component def: "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity; as in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "ADPG pyrophosphorylase complex (sensu Bacteria)" EXACT [] xref: GO:0030930 is_a: CCO:C0001082 ! ADPG pyrophosphorylase complex [Term] id: CCO:C0001084 name: heterotetrameric ADPG pyrophosphorylase complex namespace: cellular_component def: "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah, GOC:mtg_sensu] synonym: "ADPG pyrophosphorylase complex (sensu Eukaryota)" EXACT [] xref: GO:0030931 is_a: CCO:C0001082 ! ADPG pyrophosphorylase complex [Term] id: CCO:C0001085 name: amyloplast ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah] xref: GO:0030932 is_a: CCO:C0001106 ! plastid ADPG pyrophosphorylase complex relationship: part_of CCO:C0000630 ! amyloplast [Term] id: CCO:C0001086 name: chloroplast ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah] xref: GO:0030933 is_a: CCO:C0001106 ! plastid ADPG pyrophosphorylase complex is_a: CCO:C0001853 ! chloroplast part [Term] id: CCO:C0001087 name: anchoring collagen namespace: cellular_component def: "Any collagen polymer which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976] synonym: "connecting collagen" EXACT [ISBN:0721639976] synonym: "linking collagen" EXACT [ISBN:0721639976] xref: GO:0030934 is_a: CCO:C0000205 ! collagen [Term] id: CCO:C0001088 name: sheet-forming collagen namespace: cellular_component def: "Any collagen polymer in which collagen triple helices associate to form sheet-like networks." [ISBN:0721639976] synonym: "network-forming collagen" EXACT [ISBN:0815316194] xref: GO:0030935 is_a: CCO:C0000205 ! collagen [Term] id: CCO:C0001089 name: transmembrane collagen namespace: cellular_component def: "Any collagen polymer that passes through a lipid bilayer membrane." [ISBN:0721639976] synonym: "MACIT" EXACT [ISBN:0198599587] xref: GO:0030936 is_a: CCO:C0000205 ! collagen [Term] id: CCO:C0001090 name: collagen type XVII namespace: cellular_component def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices associate with hemidesmosomes and the basal lamina." [ISBN:0721639976] xref: GO:0030937 is_a: CCO:C0001089 ! transmembrane collagen [Term] id: CCO:C0001091 name: collagen type XVIII namespace: cellular_component def: "A collagen homotrimer of alpha1(XVIII) chains." [ISBN:0721639976] xref: GO:0030938 is_a: CCO:C0001087 ! anchoring collagen [Term] id: CCO:C0001092 name: glutamyl-tRNA(Gln) amidotransferase complex namespace: cellular_component def: "Complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutamyl-tRNA(Gln) amidotransferase activity ; GO:0017068'. xref: GO:0030956 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001093 name: RITS complex namespace: cellular_component def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433] xref: GO:0030958 is_a: CCO:C0001205 ! RNAi effector complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000310 ! nuclear heterochromatin [Term] id: CCO:C0001096 name: cortical microtubule cytoskeleton namespace: cellular_component def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] xref: GO:0030981 is_a: CCO:C0001055 ! cortical cytoskeleton [Term] id: CCO:C0001097 name: high molecular weight kininogen receptor complex namespace: cellular_component def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596] xref: GO:0030988 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001098 name: intraflagellar transport particle namespace: cellular_component def: "A nonmembrane-bound oliogmeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:kva, PMID:14570576] subset: goslim_pir xref: GO:0030990 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001866 ! axoneme part [Term] id: CCO:C0001099 name: intraflagellar transport particle A namespace: cellular_component def: "The smaller subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:kva, PMID:14570576] xref: GO:0030991 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001866 ! axoneme part relationship: part_of CCO:C0001098 ! intraflagellar transport particle [Term] id: CCO:C0001100 name: intraflagellar transport particle B namespace: cellular_component def: "The larger subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:kva, PMID:14570576] xref: GO:0030992 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001866 ! axoneme part relationship: part_of CCO:C0001098 ! intraflagellar transport particle [Term] id: CCO:C0001101 name: axonemal heterotrimeric kinesin-II complex namespace: cellular_component def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kva, PMID:14570576] xref: GO:0030993 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001866 ! axoneme part [Term] id: CCO:C0001102 name: linear element namespace: cellular_component def: "A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex." [Sanger:jb "Jurg Bahler"] xref: GO:0030998 is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000121 ! condensed nuclear chromosome [Term] id: CCO:C0001103 name: actin rod namespace: cellular_component def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum." [GOC:kp] xref: GO:0031002 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0001104 name: actin tubule namespace: cellular_component def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp] xref: GO:0031003 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0001103 ! actin rod [Term] id: CCO:C0001105 name: potassium ion-transporting ATPase complex namespace: cellular_component def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692, TIGR_TIGRFAMS:TIGR01497] synonym: "Kdp system complex" EXACT [] xref: GO:0031004 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001106 name: plastid ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah] xref: GO:0031009 is_a: CCO:C0001084 ! heterotetrameric ADPG pyrophosphorylase complex is_a: CCO:C0001854 ! plastid part [Term] id: CCO:C0001107 name: ISWI complex namespace: cellular_component def: "Any chromatin remodeling complex that contains an ATPase subunit of the ISWI family." [GOC:mah, PMID:15020051] xref: GO:0031010 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0001108 name: INO80 complex namespace: cellular_component def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh] xref: GO:0031011 is_a: CCO:C0000806 ! chromatin remodeling complex is_a: CCO:C0001555 ! DNA helicase complex [Term] id: CCO:C0001109 name: extracellular matrix namespace: cellular_component def: "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants)." [GOC:mah] subset: goslim_pir subset: gosubset_prok xref: GO:0031012 is_a: CCO:C0000200 ! cellular_component [Term] id: CCO:C0001110 name: karyopherin docking complex namespace: cellular_component def: "A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357] synonym: "Asm4p-containing complex" NARROW [] synonym: "nuclear pore subcomplex" BROAD [] xref: GO:0031015 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001872 ! nuclear membrane part relationship: part_of CCO:C0000260 ! nuclear pore [Term] id: CCO:C0001111 name: mitochondrial mRNA editing complex namespace: cellular_component def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607] synonym: "mitochondrial editosome" EXACT [] xref: GO:0031019 is_a: CCO:C0001945 ! mRNA editing complex [Term] id: CCO:C0001112 name: plastid mRNA editing complex namespace: cellular_component def: "An mRNA editing complex found in a plastid." [GOC:mah] synonym: "plastid editosome" EXACT [] xref: GO:0031020 is_a: CCO:C0001945 ! mRNA editing complex [Term] id: CCO:C0001113 name: interphase microtubule organizing center namespace: cellular_component def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790] synonym: "iMTOC" EXACT [] synonym: "interphase microtubule organising center" EXACT [] synonym: "interphase MTOC" EXACT [] xref: GO:0031021 is_a: CCO:C0000385 ! microtubule organizing center [Term] id: CCO:C0001114 name: glutamate synthase complex namespace: cellular_component def: "A complex that possesses glutamate synthase activity." [GOC:mah] subset: goslim_pir subset: gosubset_prok xref: GO:0031026 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001115 name: glutamate synthase complex (NADH) namespace: cellular_component def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] xref: GO:0031027 is_a: CCO:C0001114 ! glutamate synthase complex [Term] id: CCO:C0001116 name: macronucleus namespace: cellular_component def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns] xref: GO:0031039 is_a: CCO:C0000252 ! nucleus [Term] id: CCO:C0001117 name: micronucleus namespace: cellular_component def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns] xref: GO:0031040 is_a: CCO:C0000252 ! nucleus [Term] id: CCO:C0001118 name: dense core granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [PMID:14690495] xref: GO:0031045 is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001119 name: nucleocytoplasmic shuttling complex namespace: cellular_component def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah] subset: goslim_pir xref: GO:0031074 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001120 name: Nup107-160 complex namespace: cellular_component def: "A subcomplex of the nuclear pore complex (NPC) mRNA export and NPC assembly. Contains conserved nucleoporins and other proteins; for example, the Saccharomyces complex contains Nup84p, Nup85p, Nup120p, Nup145p-C, Seh1p, Sec13p, and Nup133p." [PMID:10747086, PMID:11823431, PMID:15226438] synonym: "Nup107-120 complex" EXACT [] synonym: "Nup84 complex" EXACT [] xref: GO:0031080 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001872 ! nuclear membrane part relationship: part_of CCO:C0000260 ! nuclear pore [Term] id: CCO:C0001121 name: BLOC complex namespace: cellular_component def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680] subset: goslim_pir xref: GO:0031082 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0001122 name: BLOC-1 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] xref: GO:0031083 is_a: CCO:C0001121 ! BLOC complex [Term] id: CCO:C0001123 name: BLOC-2 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569] xref: GO:0031084 is_a: CCO:C0001121 ! BLOC complex [Term] id: CCO:C0001124 name: BLOC-3 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248] xref: GO:0031085 is_a: CCO:C0001121 ! BLOC complex [Term] id: CCO:C0001125 name: platelet dense granule membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah] xref: GO:0031088 is_a: CCO:C0001031 ! secretory granule membrane relationship: part_of CCO:C0001705 ! platelet dense granule [Term] id: CCO:C0001126 name: platelet dense granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah] xref: GO:0031089 is_a: CCO:C0002132 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of CCO:C0001705 ! platelet dense granule [Term] id: CCO:C0001127 name: organelle membrane namespace: cellular_component def: "The lipid bilayer surrounding an organelle." [GOC:mah] subset: gosubset_prok xref: GO:0031090 is_a: CCO:C0000766 ! membrane is_a: CCO:C0001841 ! organelle part relationship: part_of CCO:C0002127 ! membrane-bounded organelle [Term] id: CCO:C0001128 name: platelet alpha granule namespace: cellular_component def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233] synonym: "platelet alpha-granule" EXACT [] xref: GO:0031091 is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001129 name: platelet alpha granule membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233] synonym: "platelet alpha-granule membrane" EXACT [] xref: GO:0031092 is_a: CCO:C0001031 ! secretory granule membrane relationship: part_of CCO:C0001128 ! platelet alpha granule [Term] id: CCO:C0001130 name: platelet alpha granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233] synonym: "platelet alpha-granule lumen" EXACT [] xref: GO:0031093 is_a: CCO:C0002132 ! cytoplasmic membrane-bounded vesicle lumen relationship: location_of CCO:B0001470 ! EGF_HUMAN relationship: location_of CCO:B0001471 ! TGFB1_HUMAN relationship: part_of CCO:C0001128 ! platelet alpha granule [Term] id: CCO:C0001131 name: platelet dense tubular network namespace: cellular_component def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202] subset: goslim_pir xref: GO:0031094 is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0001132 name: platelet dense tubular network membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202] xref: GO:0031095 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0001131 ! platelet dense tubular network [Term] id: CCO:C0001133 name: platelet dense tubular network lumen namespace: cellular_component def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202] xref: GO:0031096 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0001131 ! platelet dense tubular network [Term] id: CCO:C0001134 name: medial ring namespace: cellular_component def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning." [GOC:vw, PMID:15572668] synonym: "medial cortex" RELATED [] xref: GO:0031097 is_a: CCO:C0001404 ! cell division site part is_a: CCO:C0001867 ! cell cortex part [Term] id: CCO:C0001135 name: septin complex namespace: cellular_component def: "Any of several heterooligomeric complexes containing multiple septins." [GOC:mah, PMID:15385632] subset: goslim_pir xref: GO:0031105 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001867 ! cell cortex part relationship: location_of CCO:B0001319 ! A6NC65_HUMAN relationship: location_of CCO:B0001324 ! A6NFQ9_HUMAN relationship: location_of CCO:B0001335 ! A6NKP6_HUMAN relationship: location_of CCO:B0001339 ! A6NMH6_HUMAN relationship: location_of CCO:B0001846 ! Q59GE1_HUMAN relationship: location_of CCO:B0001925 ! SEP14_HUMAN relationship: location_of CCO:B0002011 ! SEPT1_HUMAN relationship: location_of CCO:B0002050 ! Q96MY5_HUMAN relationship: location_of CCO:B0002079 ! Q99648_HUMAN relationship: location_of CCO:B0002183 ! SEP10_HUMAN relationship: location_of CCO:B0013991 ! SEPT2_HUMAN-Phosphotyrosine17 relationship: location_of CCO:B0014006 ! SEPT7_HUMAN-Phosphoserine423 relationship: location_of CCO:B0023340 ! Q59H84_HUMAN relationship: location_of CCO:B0023347 ! Q9H9P7_HUMAN relationship: location_of CCO:B0023351 ! Q6B514_HUMAN relationship: location_of CCO:B0023650 ! Q53QU3_HUMAN relationship: location_of CCO:B0026253 ! SEP12_HUMAN relationship: location_of CCO:B0028285 ! A8MT51_HUMAN relationship: location_of CCO:B0030400 ! A8K7M3_HUMAN relationship: location_of CCO:B0033797 ! Q548C9_HUMAN relationship: location_of CCO:B0033798 ! Q541S4_HUMAN relationship: location_of CCO:B0041194 ! SEPT5_HUMAN-Phosphoserine225 relationship: location_of CCO:B0041227 ! B1AHR1_HUMAN relationship: location_of CCO:B0041234 ! B1AMS2_HUMAN relationship: part_of CCO:C0001405 ! septin cytoskeleton [Term] id: CCO:C0001136 name: pseudopodium namespace: cellular_component def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir synonym: "pseudopod" EXACT [] xref: GO:0031143 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0001137 name: spore wall namespace: cellular_component def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] synonym: "spore coat" EXACT [] xref: GO:0031160 is_a: CCO:C0000239 ! cell wall [Term] id: CCO:C0001138 name: contractile vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg] xref: GO:0031164 is_a: CCO:C0000356 ! vacuolar membrane relationship: part_of CCO:C0000069 ! contractile vacuole [Term] id: CCO:C0001139 name: integral to contractile vacuolar membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the contractile vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:pg] xref: GO:0031165 is_a: CCO:C0001140 ! integral to vacuolar membrane is_a: CCO:C0001198 ! intrinsic to contractile vacuolar membrane [Term] id: CCO:C0001140 name: integral to vacuolar membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031166 is_a: CCO:C0001188 ! integral to organelle membrane is_a: CCO:C0001197 ! intrinsic to vacuolar membrane [Term] id: CCO:C0001141 name: SNARE complex namespace: cellular_component def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [PMID:10872468] xref: GO:0031201 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part [Term] id: CCO:C0001142 name: endoplasmic reticulum Sec complex namespace: cellular_component def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:12158317, PMID:14617809] subset: goslim_pir synonym: "Sec complex (sensu Eukaryota)" EXACT [] xref: GO:0031205 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0001057 ! rough endoplasmic reticulum membrane [Term] id: CCO:C0001143 name: Sec complex-associated translocon complex namespace: cellular_component def: "A translocon complex physically associated with a Sec complex." [GOC:mah, PMID:12518317, PMID:14617809] xref: GO:0031206 is_a: CCO:C0000365 ! translocon complex relationship: part_of CCO:C0001142 ! endoplasmic reticulum Sec complex [Term] id: CCO:C0001144 name: Sec62/Sec63 complex namespace: cellular_component def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809] synonym: "ER protein translocation subcomplex " EXACT [] synonym: "Sec62/63 complex" EXACT [] xref: GO:0031207 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0001142 ! endoplasmic reticulum Sec complex [Term] id: CCO:C0001145 name: SCAR complex namespace: cellular_component def: "A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570] synonym: "WAVE complex" EXACT [] xref: GO:0031209 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001146 name: palmitoyltransferase complex namespace: cellular_component def: "A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh] xref: GO:0031211 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0001147 name: RSF complex namespace: cellular_component def: "A chromatin remodeling complex that mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In humans, the complex is composed of the ATPase hSNF2H and the HBXAP protein (RSF-1)." [PMID:12972596] synonym: "remodeling and spacing factor complex " EXACT [] xref: GO:0031213 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0001148 name: intrinsic to membrane namespace: cellular_component def: "Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent. subset: gosubset_prok xref: GO:0031224 is_a: CCO:C0001844 ! membrane part [Term] id: CCO:C0001149 name: anchored to membrane namespace: cellular_component def: "Tethered to a membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane." [GOC:mah] xref: GO:0031225 is_a: CCO:C0001148 ! intrinsic to membrane relationship: location_of CCO:B0001672 ! GAS1_HUMAN relationship: location_of CCO:B0002064 ! GML_HUMAN [Term] id: CCO:C0001150 name: intrinsic to plasma membrane namespace: cellular_component def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] subset: gosubset_prok xref: GO:0031226 is_a: CCO:C0001148 ! intrinsic to membrane is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001151 name: intrinsic to endoplasmic reticulum membrane namespace: cellular_component def: "Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031227 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0001152 name: intrinsic to Golgi membrane namespace: cellular_component def: "Located in the Golgi membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031228 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001850 ! Golgi apparatus part relationship: part_of CCO:C0000021 ! Golgi membrane [Term] id: CCO:C0001153 name: intrinsic to nuclear inner membrane namespace: cellular_component def: "Located in the nuclear inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031229 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001872 ! nuclear membrane part relationship: part_of CCO:C0000254 ! nuclear inner membrane [Term] id: CCO:C0001154 name: intrinsic to cell outer membrane namespace: cellular_component def: "Located in the cell outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "intrinsic to outer membrane (sensu Gram-negative Bacteria)" EXACT [] synonym: "intrinsic to outer membrane (sensu Proteobacteria)" EXACT [] xref: GO:0031230 is_a: CCO:C0001148 ! intrinsic to membrane is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0000557 ! cell outer membrane [Term] id: CCO:C0001155 name: intrinsic to peroxisomal membrane namespace: cellular_component def: "Located in the peroxisomal membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031231 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001858 ! peroxisomal part relationship: part_of CCO:C0000360 ! peroxisomal membrane [Term] id: CCO:C0001156 name: extrinsic to external side of plasma membrane namespace: cellular_component def: "Loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah] xref: GO:0031232 is_a: CCO:C0000899 ! extrinsic to plasma membrane relationship: part_of CCO:C0000702 ! external side of plasma membrane [Term] id: CCO:C0001157 name: intrinsic to external side of plasma membrane namespace: cellular_component def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm." [GOC:mah] xref: GO:0031233 is_a: CCO:C0001150 ! intrinsic to plasma membrane relationship: part_of CCO:C0000702 ! external side of plasma membrane [Term] id: CCO:C0001158 name: extrinsic to internal side of plasma membrane namespace: cellular_component def: "Loosely bound to the surface of the plasma membrane that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah] xref: GO:0031234 is_a: CCO:C0000899 ! extrinsic to plasma membrane is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0000703 ! internal side of plasma membrane [Term] id: CCO:C0001159 name: intrinsic to internal side of plasma membrane namespace: cellular_component def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the cytoplasm." [GOC:mah] xref: GO:0031235 is_a: CCO:C0001150 ! intrinsic to plasma membrane relationship: part_of CCO:C0000703 ! internal side of plasma membrane [Term] id: CCO:C0001160 name: extrinsic to external side of plasma membrane, in periplasmic space namespace: cellular_component def: "Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "extrinsic to external side of plasma membrane, in periplasmic space (sensu Gram-negative Bacteria)" EXACT [] synonym: "extrinsic to external side of plasma membrane, in periplasmic space (sensu Proteobacteria)" EXACT [] xref: GO:0031236 xref: GO:0031238 is_a: CCO:C0001156 ! extrinsic to external side of plasma membrane is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0000997 ! outer membrane-bounded periplasmic space [Term] id: CCO:C0001161 name: intrinsic to external side of plasma membrane, in periplasmic space namespace: cellular_component def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "intrinsic to external side of plasma membrane, in periplasmic space (sensu Gram-negative Bacteria)" EXACT [] synonym: "intrinsic to external side of plasma membrane, in periplasmic space (sensu Proteobacteria)" EXACT [] xref: GO:0031237 xref: GO:0031239 is_a: CCO:C0001157 ! intrinsic to external side of plasma membrane is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0000997 ! outer membrane-bounded periplasmic space [Term] id: CCO:C0001162 name: external side of cell outer membrane namespace: cellular_component def: "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "external side of outer membrane" RELATED [] xref: GO:0031240 is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0000557 ! cell outer membrane [Term] id: CCO:C0001163 name: internal side of cell outer membrane namespace: cellular_component def: "The side of the outer membrane that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "internal side of outer membrane" EXACT [] xref: GO:0031241 is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0000557 ! cell outer membrane [Term] id: CCO:C0001164 name: extrinsic to external side of cell outer membrane namespace: cellular_component def: "Loosely bound to the surface of the outer membrane of the cell that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "extrinsic to external side of outer membrane" EXACT [] xref: GO:0031242 is_a: CCO:C0001166 ! extrinsic to cell outer membrane relationship: part_of CCO:C0001162 ! external side of cell outer membrane [Term] id: CCO:C0001165 name: intrinsic to external side of cell outer membrane namespace: cellular_component def: "Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the periplasm." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "intrinsic to external side of outer membrane" EXACT [] xref: GO:0031243 is_a: CCO:C0001154 ! intrinsic to cell outer membrane relationship: part_of CCO:C0001162 ! external side of cell outer membrane [Term] id: CCO:C0001166 name: extrinsic to cell outer membrane namespace: cellular_component def: "Loosely bound to one surface of the outer membrane of the cell, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "extrinsic to outer membrane (sensu Gram-negative Bacteria)" EXACT [] synonym: "extrinsic to outer membrane (sensu Proteobacteria)" EXACT [] xref: GO:0031244 is_a: CCO:C0000900 ! extrinsic to membrane is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0000557 ! cell outer membrane [Term] id: CCO:C0001167 name: extrinsic to internal side of cell outer membrane namespace: cellular_component def: "Loosely bound to the surface of the outer membrane of the cell that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "extrinsic to internal side of outer membrane" EXACT [] xref: GO:0031245 is_a: CCO:C0001166 ! extrinsic to cell outer membrane relationship: part_of CCO:C0001163 ! internal side of cell outer membrane [Term] id: CCO:C0001168 name: intrinsic to internal side of cell outer membrane namespace: cellular_component def: "Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the periplasm." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "intrinsic to internal side of outer membrane" EXACT [] xref: GO:0031246 is_a: CCO:C0001154 ! intrinsic to cell outer membrane relationship: part_of CCO:C0001163 ! internal side of cell outer membrane [Term] id: CCO:C0001169 name: protein acetyltransferase complex namespace: cellular_component def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] subset: goslim_pir xref: GO:0031248 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001170 name: anaerobic ribonucleoside-triphosphate reductase complex namespace: cellular_component def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg] xref: GO:0031250 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001171 name: PAN complex namespace: cellular_component def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670] synonym: "poly(A) nuclease complex" EXACT [] xref: GO:0031251 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001172 name: leading edge namespace: cellular_component def: "The area of a motile cell closest to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "front of cell" EXACT [] xref: GO:0031252 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001173 name: cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cell surface projection." [GOC:mah] synonym: "membrane extension" RELATED [] synonym: "membrane projection" RELATED [] xref: GO:0031253 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001881 ! cell projection part [Term] id: CCO:C0001174 name: trailing edge namespace: cellular_component def: "The area of a motile cell opposite to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "back of cell" EXACT [] xref: GO:0031254 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001175 name: lateral part of motile cell namespace: cellular_component def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg] xref: GO:0031255 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001176 name: leading edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah] xref: GO:0031256 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0001172 ! leading edge [Term] id: CCO:C0001177 name: trailing edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah] xref: GO:0031257 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0001174 ! trailing edge [Term] id: CCO:C0001178 name: lamellipodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah] xref: GO:0031258 is_a: CCO:C0001173 ! cell projection membrane is_a: CCO:C0001176 ! leading edge membrane relationship: part_of CCO:C0000935 ! lamellipodium [Term] id: CCO:C0001179 name: uropod membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah] synonym: "uropodium membrane" EXACT [] xref: GO:0031259 is_a: CCO:C0001173 ! cell projection membrane is_a: CCO:C0001177 ! trailing edge membrane relationship: part_of CCO:C0000189 ! uropod [Term] id: CCO:C0001180 name: pseudopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah] xref: GO:0031260 is_a: CCO:C0001173 ! cell projection membrane relationship: part_of CCO:C0001136 ! pseudopodium [Term] id: CCO:C0001181 name: DNA replication preinitiation complex namespace: cellular_component def: "A multiprotein complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others." [PMID:12694535, PMID:15194812] synonym: "pre-IC" EXACT [] xref: GO:0031261 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0001182 name: Ndc80 complex namespace: cellular_component def: "A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore." [PMID:15509863, PMID:15661517] synonym: "Nuf2-Ndc80 complex" EXACT [] xref: GO:0031262 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000103 ! kinetochore [Term] id: CCO:C0001183 name: death-inducing signaling complex namespace: cellular_component def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] subset: goslim_pir synonym: "death-inducing signalling complex" EXACT [] synonym: "DISC" EXACT [] xref: GO:0031264 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001184 name: CD95 death-inducing signaling complex namespace: cellular_component def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] synonym: "CD95 death-inducing signalling complex" EXACT [] synonym: "CD95 DISC" EXACT [] synonym: "Fas death-inducing signaling complex" EXACT [] xref: GO:0031265 is_a: CCO:C0001183 ! death-inducing signaling complex [Term] id: CCO:C0001185 name: TRAIL death-inducing signaling complex namespace: cellular_component def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] synonym: "TRAIL death-inducing signalling complex" EXACT [] synonym: "TRAIL DISC" EXACT [] xref: GO:0031266 is_a: CCO:C0001183 ! death-inducing signaling complex [Term] id: CCO:C0001186 name: replication fork protection complex namespace: cellular_component def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656] synonym: "Swi1-Swi3 complex" NARROW [] xref: GO:0031298 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0001793 ! nuclear replication fork [Term] id: CCO:C0001187 name: intrinsic to organelle membrane namespace: cellular_component def: "Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031300 is_a: CCO:C0001148 ! intrinsic to membrane is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0001127 ! organelle membrane [Term] id: CCO:C0001188 name: integral to organelle membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031301 is_a: CCO:C0000767 ! integral to membrane is_a: CCO:C0001187 ! intrinsic to organelle membrane [Term] id: CCO:C0001189 name: intrinsic to endosome membrane namespace: cellular_component def: "Located in the endosome membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031302 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001859 ! endosomal part relationship: part_of CCO:C0000713 ! endosome membrane [Term] id: CCO:C0001190 name: integral to endosome membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the endosome membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031303 is_a: CCO:C0001188 ! integral to organelle membrane is_a: CCO:C0001189 ! intrinsic to endosome membrane [Term] id: CCO:C0001191 name: intrinsic to mitochondrial inner membrane namespace: cellular_component def: "Located in the mitochondrial inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031304 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0001192 name: integral to mitochondrial inner membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031305 is_a: CCO:C0001191 ! intrinsic to mitochondrial inner membrane is_a: CCO:C0001472 ! integral to mitochondrial membrane [Term] id: CCO:C0001193 name: intrinsic to mitochondrial outer membrane namespace: cellular_component def: "Located in the mitochondrial outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031306 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000327 ! mitochondrial outer membrane [Term] id: CCO:C0001194 name: integral to mitochondrial outer membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031307 is_a: CCO:C0001193 ! intrinsic to mitochondrial outer membrane is_a: CCO:C0001472 ! integral to mitochondrial membrane [Term] id: CCO:C0001195 name: intrinsic to nuclear outer membrane namespace: cellular_component def: "Located in the nuclear outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031308 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001872 ! nuclear membrane part relationship: part_of CCO:C0000257 ! nuclear outer membrane [Term] id: CCO:C0001196 name: integral to nuclear outer membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031309 is_a: CCO:C0001188 ! integral to organelle membrane is_a: CCO:C0001195 ! intrinsic to nuclear outer membrane [Term] id: CCO:C0001197 name: intrinsic to vacuolar membrane namespace: cellular_component def: "Located in the vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031310 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001856 ! vacuolar part relationship: part_of CCO:C0000356 ! vacuolar membrane [Term] id: CCO:C0001198 name: intrinsic to contractile vacuolar membrane namespace: cellular_component def: "Located in the contractile vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031311 is_a: CCO:C0001197 ! intrinsic to vacuolar membrane relationship: part_of CCO:C0001138 ! contractile vacuolar membrane [Term] id: CCO:C0001199 name: extrinsic to organelle membrane namespace: cellular_component def: "Loosely bound to one surface of an organelle membrane, but not integrated into the hydrophobic region." [GOC:mah] xref: GO:0031312 is_a: CCO:C0000900 ! extrinsic to membrane is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0001127 ! organelle membrane [Term] id: CCO:C0001200 name: extrinsic to endosome membrane namespace: cellular_component def: "Loosely bound to one surface of the endosome membrane, but not integrated into the hydrophobic region." [GOC:mah] xref: GO:0031313 is_a: CCO:C0001199 ! extrinsic to organelle membrane is_a: CCO:C0001859 ! endosomal part relationship: part_of CCO:C0000713 ! endosome membrane [Term] id: CCO:C0001201 name: extrinsic to mitochondrial inner membrane namespace: cellular_component def: "Loosely bound to one surface of the mitochondrial inner membrane, but not integrated into the hydrophobic region." [GOC:mah] xref: GO:0031314 is_a: CCO:C0001199 ! extrinsic to organelle membrane is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0001202 name: extrinsic to mitochondrial outer membrane namespace: cellular_component def: "Loosely bound to one surface of the mitochondrial outer membrane, but not integrated into the hydrophobic region." [GOC:mah] xref: GO:0031315 is_a: CCO:C0001199 ! extrinsic to organelle membrane is_a: CCO:C0001874 ! mitochondrial membrane part [Term] id: CCO:C0001203 name: extrinsic to nuclear outer membrane namespace: cellular_component def: "Loosely bound to one surface of the nuclear outer membrane, but not integrated into the hydrophobic region." [GOC:mah] xref: GO:0031316 is_a: CCO:C0001199 ! extrinsic to organelle membrane is_a: CCO:C0001872 ! nuclear membrane part relationship: part_of CCO:C0000257 ! nuclear outer membrane [Term] id: CCO:C0001204 name: tripartite ATP-independent periplasmic transporter complex namespace: cellular_component def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using enery from ion gradients." [GOC:mlg] subset: gosubset_prok synonym: "TRAP transporter complex" EXACT [] synonym: "TRAP-T transporter complex" EXACT [] xref: GO:0031317 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001205 name: RNAi effector complex namespace: cellular_component def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433] subset: goslim_pir xref: GO:0031332 is_a: CCO:C0001019 ! ribonucleoprotein complex [Term] id: CCO:C0001206 name: intrinsic to plastid membrane namespace: cellular_component def: "Located in a plastid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031350 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0001634 ! plastid membrane [Term] id: CCO:C0001207 name: integral to plastid membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a plastid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031351 is_a: CCO:C0001188 ! integral to organelle membrane is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0001634 ! plastid membrane [Term] id: CCO:C0001208 name: intrinsic to plastid inner membrane namespace: cellular_component def: "Located in a plastid inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031352 is_a: CCO:C0001206 ! intrinsic to plastid membrane relationship: part_of CCO:C0000656 ! plastid inner membrane [Term] id: CCO:C0001209 name: integral to plastid inner membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a plastid inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031353 is_a: CCO:C0001207 ! integral to plastid membrane relationship: part_of CCO:C0000656 ! plastid inner membrane [Term] id: CCO:C0001210 name: intrinsic to plastid outer membrane namespace: cellular_component def: "Located in a plastid outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031354 is_a: CCO:C0001206 ! intrinsic to plastid membrane relationship: part_of CCO:C0000655 ! plastid outer membrane [Term] id: CCO:C0001211 name: integral to plastid outer membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a plastid outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031355 is_a: CCO:C0001207 ! integral to plastid membrane relationship: part_of CCO:C0000655 ! plastid outer membrane [Term] id: CCO:C0001212 name: intrinsic to chloroplast inner membrane namespace: cellular_component def: "Located in the chloroplast inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031356 is_a: CCO:C0001208 ! intrinsic to plastid inner membrane is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000694 ! chloroplast inner membrane [Term] id: CCO:C0001213 name: integral to chloroplast inner membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031357 is_a: CCO:C0001209 ! integral to plastid inner membrane is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000694 ! chloroplast inner membrane [Term] id: CCO:C0001214 name: intrinsic to chloroplast outer membrane namespace: cellular_component def: "Located in the chloroplast outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031358 is_a: CCO:C0001210 ! intrinsic to plastid outer membrane is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000695 ! chloroplast outer membrane [Term] id: CCO:C0001215 name: integral to chloroplast outer membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031359 is_a: CCO:C0001211 ! integral to plastid outer membrane is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000695 ! chloroplast outer membrane [Term] id: CCO:C0001216 name: intrinsic to thylakoid membrane namespace: cellular_component def: "Located in a thylakoid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] xref: GO:0031360 is_a: CCO:C0001187 ! intrinsic to organelle membrane is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0001684 ! thylakoid membrane [Term] id: CCO:C0001217 name: integral to thylakoid membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0031361 is_a: CCO:C0001188 ! integral to organelle membrane is_a: CCO:C0001855 ! thylakoid part relationship: part_of CCO:C0001684 ! thylakoid membrane [Term] id: CCO:C0001218 name: anchored to external side of plasma membrane namespace: cellular_component def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah] xref: GO:0031362 is_a: CCO:C0001157 ! intrinsic to external side of plasma membrane is_a: CCO:C0001959 ! anchored to plasma membrane [Term] id: CCO:C0001219 name: ubiquitin conjugating enzyme complex namespace: cellular_component def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah] subset: goslim_pir synonym: "E2 complex" RELATED [] xref: GO:0031371 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001220 name: UBC13-MMS2 complex namespace: cellular_component def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p." [GOC:mah, PMID:15772086] xref: GO:0031372 is_a: CCO:C0001219 ! ubiquitin conjugating enzyme complex [Term] id: CCO:C0001221 name: cytosolic fatty acid synthase complex namespace: cellular_component def: "A fatty acid synthase complex located in the cytosol." [GOC:mah] synonym: "cytosolic FAS complex" EXACT [] xref: GO:0031373 is_a: CCO:C0000403 ! fatty acid synthase complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0001222 name: cytosolic type I fatty acid synthase complex namespace: cellular_component def: "A cytosolic fatty acid synthase complex in which each polypeptide chain contains several different catalytic sites." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] synonym: "cytosolic type I FAS complex" EXACT [] xref: GO:0031374 is_a: CCO:C0001221 ! cytosolic fatty acid synthase complex [Term] id: CCO:C0001223 name: type II fatty acid synthase complex namespace: cellular_component def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] synonym: "type II FAS" EXACT [] synonym: "type II FAS complex" EXACT [] synonym: "type II fatty acid synthase" EXACT [] xref: GO:0031375 is_a: CCO:C0000403 ! fatty acid synthase complex [Term] id: CCO:C0001224 name: cytosolic type II fatty acid synthase complex namespace: cellular_component def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] synonym: "cytosolic type II FAS complex" EXACT [] xref: GO:0031376 is_a: CCO:C0001221 ! cytosolic fatty acid synthase complex is_a: CCO:C0001223 ! type II fatty acid synthase complex [Term] id: CCO:C0001225 name: mitochondrial type II fatty acid synthase complex namespace: cellular_component def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] synonym: "mitochondrial type II FAS complex" EXACT [] xref: GO:0031377 is_a: CCO:C0001223 ! type II fatty acid synthase complex is_a: CCO:C0001848 ! mitochondrial part [Term] id: CCO:C0001226 name: plastid type II fatty acid synthase complex namespace: cellular_component def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] synonym: "plastid type II FAS complex" EXACT [] xref: GO:0031378 is_a: CCO:C0001223 ! type II fatty acid synthase complex is_a: CCO:C0001854 ! plastid part [Term] id: CCO:C0001227 name: RNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah] xref: GO:0031379 is_a: CCO:C0001068 ! RNA polymerase complex [Term] id: CCO:C0001228 name: nuclear RNA-directed RNA polymerase complex namespace: cellular_component def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976] synonym: "Rdr1 complex" NARROW [] synonym: "RDRC" EXACT [] xref: GO:0031380 is_a: CCO:C0001227 ! RNA-directed RNA polymerase complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001229 name: viral RNA-directed RNA polymerase complex namespace: cellular_component def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301] xref: GO:0031381 is_a: CCO:C0001227 ! RNA-directed RNA polymerase complex [Term] id: CCO:C0001230 name: MPF complex namespace: cellular_component def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216] xref: GO:0031387 is_a: CCO:C0000053 ! cyclin-dependent protein kinase holoenzyme complex [Term] id: CCO:C0001231 name: Rad17 RFC-like complex namespace: cellular_component def: "A pentameric complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Saccharomyces the subunits are known as Rad17p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842] synonym: "Rad17-RFC" EXACT [] synonym: "Rad17-RLC" EXACT [] synonym: "RFC (Rad17)" EXACT [] xref: GO:0031389 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0001232 name: Ctf18 RFC-like complex namespace: cellular_component def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842] synonym: "Ctf18-RFC" EXACT [] synonym: "Ctf18-RLC" EXACT [] synonym: "RFC (Ctf18)" EXACT [] xref: GO:0031390 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0001233 name: Elg1 RFC-like complex namespace: cellular_component def: "A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842] synonym: "Elg1-RFC" EXACT [] synonym: "Elg1-RLC" EXACT [] synonym: "RFC (Elg1)" EXACT [] xref: GO:0031391 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0001234 name: bursicon neuropeptide hormone complex namespace: cellular_component def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc] xref: GO:0031395 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0001235 name: cytoplasmic vesicle namespace: cellular_component def: "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] subset: gosubset_prok xref: GO:0031410 is_a: CCO:C0001374 ! vesicle is_a: CCO:C0001745 ! intracellular organelle is_a: CCO:C0001863 ! cytoplasmic part relationship: location_of CCO:B0010653 ! ATM_HUMAN-Phosphothreonine72 [Term] id: CCO:C0001236 name: gas vesicle namespace: cellular_component def: "A hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content aquatic microbes are able to perform vertical migrations." [PMID:8177173] subset: gosubset_prok xref: GO:0031411 is_a: CCO:C0001235 ! cytoplasmic vesicle is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle [Term] id: CCO:C0001237 name: N-terminal protein acetyltransferase complex namespace: cellular_component def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah] synonym: "NAT complex" EXACT [] xref: GO:0031414 is_a: CCO:C0001169 ! protein acetyltransferase complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001238 name: NatA complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471] synonym: "N-terminal acetyltransferase A complex" EXACT [] xref: GO:0031415 is_a: CCO:C0001237 ! N-terminal protein acetyltransferase complex [Term] id: CCO:C0001239 name: NatB complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471] synonym: "N-terminal acetyltransferase B complex" EXACT [] xref: GO:0031416 is_a: CCO:C0001237 ! N-terminal protein acetyltransferase complex [Term] id: CCO:C0001240 name: NatC complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471] synonym: "N-terminal acetyltransferase C complex" EXACT [] xref: GO:0031417 is_a: CCO:C0001237 ! N-terminal protein acetyltransferase complex [Term] id: CCO:C0001241 name: invertasome namespace: cellular_component def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277] xref: GO:0031421 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001242 name: RecQ helicase-Topo III complex namespace: cellular_component def: "A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human." [PMID:15889139] synonym: "Sgs1-Top3 complex" NARROW [] xref: GO:0031422 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0001243 name: box C/D snoRNP complex namespace: cellular_component def: "A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type." [ISBN:0879695897] xref: GO:0031428 is_a: CCO:C0000322 ! small nucleolar ribonucleoprotein complex [Term] id: CCO:C0001244 name: box H/ACA snoRNP complex namespace: cellular_component def: "A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type." [ISBN:0879695897] xref: GO:0031429 is_a: CCO:C0000322 ! small nucleolar ribonucleoprotein complex [Term] id: CCO:C0001245 name: M band namespace: cellular_component def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815316194] synonym: "M disc" EXACT [] synonym: "M line" NARROW [] synonym: "mesophragma" EXACT [] synonym: "midline" BROAD [] xref: GO:0031430 is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0001326 ! A band [Term] id: CCO:C0001246 name: Dbf4-dependent protein kinase complex namespace: cellular_component def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100] synonym: "Cdc7-Dbf4 complex" NARROW [] synonym: "DDK" EXACT [] synonym: "Hsk1-Dfp1 kinase complex" NARROW [] xref: GO:0031431 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001247 name: BRCA1-BARD1 complex namespace: cellular_component def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778] xref: GO:0031436 is_a: CCO:C0000027 ! nuclear ubiquitin ligase complex relationship: location_of CCO:B0002086 ! BARD1_HUMAN relationship: location_of CCO:B0010848 ! BRCA1_HUMAN-Phosphoserine1330 [Term] id: CCO:C0001248 name: cullin-RING ubiquitin ligase complex namespace: cellular_component def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] synonym: "CRL complex" EXACT [] synonym: "cullin complex" EXACT [] synonym: "cullin-RING ligase" RELATED [] xref: GO:0031461 is_a: CCO:C0000026 ! ubiquitin ligase complex relationship: location_of CCO:B0001759 ! CUL1_HUMAN relationship: location_of CCO:B0001760 ! CUL2_HUMAN relationship: location_of CCO:B0001888 ! Q5TCY3_HUMAN relationship: location_of CCO:B0002027 ! CUL5_HUMAN [Term] id: CCO:C0001249 name: Cul2-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] synonym: "CBC complex" BROAD [] synonym: "CDL2 complex" EXACT [] synonym: "CRL2 complex" EXACT [] synonym: "cullin-RING ligase 2" EXACT [] synonym: "EC2S complex" BROAD [] synonym: "ECS complex" BROAD [] synonym: "SCF2 complex" RELATED [] synonym: "VBC complex" NARROW [] xref: GO:0031462 is_a: CCO:C0001248 ! cullin-RING ubiquitin ligase complex [Term] id: CCO:C0001250 name: Cul3-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] synonym: "BC3B complex" EXACT [] synonym: "BCR3 complex" EXACT [] synonym: "CDL3 complex" EXACT [] synonym: "CRL3 complex" EXACT [] synonym: "cullin-RING ligase 3" EXACT [] synonym: "SCF3 complex" RELATED [] xref: GO:0031463 is_a: CCO:C0001248 ! cullin-RING ubiquitin ligase complex [Term] id: CCO:C0001251 name: Cul4A-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063] synonym: "CDL4 complex" EXACT [] synonym: "CRL4 complex" EXACT [] synonym: "cullin-RING ligase 4A" EXACT [] synonym: "DCX complex" EXACT [] synonym: "SCF4 complex" RELATED [] synonym: "VDC complex" NARROW [] xref: GO:0031464 is_a: CCO:C0001248 ! cullin-RING ubiquitin ligase complex [Term] id: CCO:C0001252 name: Cul4B-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063] synonym: "cullin-RING ligase 4B" EXACT [] xref: GO:0031465 is_a: CCO:C0001248 ! cullin-RING ubiquitin ligase complex [Term] id: CCO:C0001253 name: Cul5-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] synonym: "CDL5 complex" EXACT [] synonym: "CRL5 complex" EXACT [] synonym: "cullin-RING ligase 5" EXACT [] synonym: "EC2S complex" BROAD [] synonym: "SCF5 complex" RELATED [] xref: GO:0031466 is_a: CCO:C0001248 ! cullin-RING ubiquitin ligase complex [Term] id: CCO:C0001254 name: Cul7-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063] synonym: "CDL7 complex" EXACT [] synonym: "CRL7 complex" EXACT [] synonym: "cullin-RING ligase 7" EXACT [] synonym: "SCF7 complex" EXACT [] xref: GO:0031467 is_a: CCO:C0001248 ! cullin-RING ubiquitin ligase complex [Term] id: CCO:C0001255 name: polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] subset: goslim_pir subset: gosubset_prok xref: GO:0031469 is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle [Term] id: CCO:C0001256 name: carboxysome namespace: cellular_component def: "An organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708] subset: gosubset_prok xref: GO:0031470 is_a: CCO:C0001255 ! polyhedral organelle [Term] id: CCO:C0001257 name: ethanolamine degradation polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753] subset: gosubset_prok synonym: "ethanolamine metabolosome" RELATED [] xref: GO:0031471 is_a: CCO:C0001255 ! polyhedral organelle [Term] id: CCO:C0001258 name: propanediol degradation polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] subset: gosubset_prok xref: GO:0031472 is_a: CCO:C0001255 ! polyhedral organelle [Term] id: CCO:C0001259 name: myosin IV complex namespace: cellular_component def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031474 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001260 name: myosin V complex namespace: cellular_component def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localisation and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031475 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001261 name: myosin VI complex namespace: cellular_component def: "A myosin complex containing a dimer of class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031476 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001262 name: myosin VII complex namespace: cellular_component def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031477 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001263 name: myosin VIII complex namespace: cellular_component def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031478 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001264 name: myosin IX complex namespace: cellular_component def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031479 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001265 name: myosin X complex namespace: cellular_component def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031480 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001266 name: myosin XI complex namespace: cellular_component def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031481 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001267 name: myosin XII complex namespace: cellular_component def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031482 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001268 name: myosin XIII complex namespace: cellular_component def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031483 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001269 name: myosin XIV complex namespace: cellular_component def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031484 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001270 name: myosin XV complex namespace: cellular_component def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031485 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001271 name: myosin XVI complex namespace: cellular_component def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886] xref: GO:0031486 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001272 name: myosin XVII complex namespace: cellular_component def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031487 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001273 name: myosin XVIII complex namespace: cellular_component def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886] xref: GO:0031488 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001274 name: TRAMP complex namespace: cellular_component def: "A multiprotein complex, which in yeast consists of Trf4p, Air1p or Air2p and Mtr4p. This nuclear RNA surveillance and quality control complex is involved in the distributive polyadenylation of substrates that include: hypomodified and incorrectly folded tRNAs, snoRNA precursors and rRNA precursors. It is also required for the degradative activity of the nuclear exosome in vivo." [PMID:15828860, PMID:15935758] synonym: "Trf4 complex" EXACT [] synonym: "Trf4 poly(A) polymerase complex" EXACT [] synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" EXACT [] xref: GO:0031499 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001275 name: Tea1 cell-end complex namespace: cellular_component def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270] xref: GO:0031500 is_a: CCO:C0000435 ! microtubule associated complex relationship: part_of CCO:C0000017 ! polarisome [Term] id: CCO:C0001276 name: mannosyltransferase complex namespace: cellular_component def: "A complex that posseses mannosyltransferase activity." [GOC:mah] subset: goslim_pir xref: GO:0031501 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001277 name: dolichyl-phosphate-mannose-protein mannosyltransferase complex namespace: cellular_component def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, PMID:15948957] synonym: "PMT family mannosyltransferase complex" RELATED [] synonym: "protein O-mannosyltransferase complex" EXACT [] xref: GO:0031502 is_a: CCO:C0001276 ! mannosyltransferase complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0001278 name: SUMO activating enzyme complex namespace: cellular_component def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841] synonym: "SAE" EXACT [] synonym: "SUMO E1 activator enzyme complex" EXACT [] xref: GO:0031510 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001279 name: Mis6-Sim4 complex namespace: cellular_component def: "A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182] synonym: "Mis6 centromere subcomplex" NARROW [] synonym: "Sim4 complex" EXACT [] xref: GO:0031511 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000158 ! inner kinetochore of condensed chromosome [Term] id: CCO:C0001280 name: motile primary cilium namespace: cellular_component def: "A specialized primary cilium that contains a 9 + 0 arrangement of microtubules, radial spokes, and a dynein apparatus, but no inner doublet microtubules. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface." [GOC:kva] xref: GO:0031512 is_a: CCO:C0000481 ! cilium [Term] id: CCO:C0001281 name: nonmotile primary cilium namespace: cellular_component def: "An immotile primary cilium that may be missing the central pair of microtubules, or the central pair of microtubules and outer dynein arms. Some primary cilia also have altered arrangements of outer microtubules (fewer than nine and/or not always present as doublets). Nonmotile primary cilia typically function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kna] xref: GO:0031513 is_a: CCO:C0000481 ! cilium [Term] id: CCO:C0001282 name: motile secondary cilium namespace: cellular_component def: "A cilium that consists of a 9 + 2 arrangement of microtubules, radial spokes, and a dynein apparatus. Motile cilia, found on cells that line the lumenal ducts of various tissues, beat with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface." [GOC:kva] xref: GO:0031514 is_a: CCO:C0000481 ! cilium [Term] id: CCO:C0001283 name: tRNA (m1A) methyltransferase complex namespace: cellular_component def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239] subset: gosubset_prok xref: GO:0031515 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001781 ! tRNA methyltransferase complex [Term] id: CCO:C0001284 name: CBF3 complex namespace: cellular_component def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032] xref: GO:0031518 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000102 ! chromosome, pericentric region [Term] id: CCO:C0001285 name: PcG protein complex namespace: cellular_component def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908] subset: goslim_pir synonym: "Polycomb Group protein complex" EXACT [] xref: GO:0031519 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001286 name: plasma membrane of cell tip namespace: cellular_component def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah] xref: GO:0031520 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0002013 ! cell tip [Term] id: CCO:C0001287 name: spitzenkorper namespace: cellular_component def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451] xref: GO:0031521 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0000166 ! hyphal tip [Term] id: CCO:C0001289 name: Myb complex namespace: cellular_component def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] synonym: "Myeloblastosis proto-oncogene protein complex" EXACT [] xref: GO:0031523 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0001290 name: brush border membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah] xref: GO:0031526 is_a: CCO:C0001173 ! cell projection membrane relationship: part_of CCO:C0000460 ! brush border [Term] id: CCO:C0001291 name: filopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah] xref: GO:0031527 is_a: CCO:C0001173 ! cell projection membrane relationship: part_of CCO:C0000989 ! filopodium [Term] id: CCO:C0001292 name: microvillus membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah] xref: GO:0031528 is_a: CCO:C0001173 ! cell projection membrane relationship: part_of CCO:C0000459 ! microvillus [Term] id: CCO:C0001293 name: mRNA capping enzyme complex namespace: cellular_component def: "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in Sz. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220] synonym: "mRNA (guanine-N7) methyltransferase complex" EXACT [] synonym: "mRNA cap methyltransferase complex" EXACT [] xref: GO:0031533 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001294 name: cellular bud neck polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790] xref: GO:0031560 is_a: CCO:C0000017 ! polarisome relationship: part_of CCO:C0000487 ! cellular bud neck [Term] id: CCO:C0001295 name: cellular bud tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790] xref: GO:0031561 is_a: CCO:C0000017 ! polarisome relationship: part_of CCO:C0000486 ! cellular bud tip [Term] id: CCO:C0001296 name: hyphal tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451] xref: GO:0031562 is_a: CCO:C0000017 ! polarisome relationship: part_of CCO:C0000166 ! hyphal tip [Term] id: CCO:C0001297 name: mating projection tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532] xref: GO:0031563 is_a: CCO:C0000017 ! polarisome is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0001770 ! mating projection tip [Term] id: CCO:C0001298 name: AMP-activated protein kinase complex namespace: cellular_component def: "A protein complex that possesses AMP-dependent protein kinase activity." [GOC:mah] synonym: "5'-AMP-activated protein kinase complex" EXACT [] synonym: "Snf1 kinase complex" NARROW [] synonym: "Snf1 serine/threonine protein kinase complex" NARROW [] xref: GO:0031588 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001299 name: centrosomal corona namespace: cellular_component def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah] comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material. xref: GO:0031592 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001869 ! microtubule organizing center part relationship: part_of CCO:C0000383 ! centrosome [Term] id: CCO:C0001300 name: neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction." [GOC:nln] xref: GO:0031594 is_a: CCO:C0001900 ! synapse relationship: location_of CCO:B0001802 ! CD5R1_HUMAN relationship: location_of CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 [Term] id: CCO:C0001301 name: nuclear proteasome complex namespace: cellular_component def: "A proteasome found in the nucleus of a cell." [GOC:mah] xref: GO:0031595 is_a: CCO:C0001847 ! nuclear part is_a: CCO:C0002078 ! proteasome complex [Term] id: CCO:C0001302 name: ER proteasome complex namespace: cellular_component def: "A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah] xref: GO:0031596 is_a: CCO:C0001851 ! endoplasmic reticulum part is_a: CCO:C0002078 ! proteasome complex [Term] id: CCO:C0001304 name: nuclear proteasome regulatory particle namespace: cellular_component def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah] xref: GO:0031598 is_a: CCO:C0001847 ! nuclear part is_a: CCO:C0002079 ! proteasome regulatory particle relationship: part_of CCO:C0001301 ! nuclear proteasome complex [Term] id: CCO:C0001305 name: ER proteasome regulatory particle namespace: cellular_component def: "The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] xref: GO:0031599 is_a: CCO:C0001851 ! endoplasmic reticulum part is_a: CCO:C0002079 ! proteasome regulatory particle relationship: part_of CCO:C0001302 ! ER proteasome complex [Term] id: CCO:C0001307 name: nuclear proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah] xref: GO:0031601 is_a: CCO:C0001847 ! nuclear part is_a: CCO:C0002080 ! proteasome core complex relationship: part_of CCO:C0001301 ! nuclear proteasome complex [Term] id: CCO:C0001308 name: ER proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] xref: GO:0031602 is_a: CCO:C0001851 ! endoplasmic reticulum part is_a: CCO:C0002080 ! proteasome core complex relationship: part_of CCO:C0001302 ! ER proteasome complex [Term] id: CCO:C0001310 name: nuclear proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] xref: GO:0031604 is_a: CCO:C0001847 ! nuclear part is_a: CCO:C0002083 ! proteasome core complex, alpha-subunit complex relationship: part_of CCO:C0001307 ! nuclear proteasome core complex [Term] id: CCO:C0001311 name: ER proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] xref: GO:0031605 is_a: CCO:C0001851 ! endoplasmic reticulum part is_a: CCO:C0002083 ! proteasome core complex, alpha-subunit complex relationship: part_of CCO:C0001308 ! ER proteasome core complex [Term] id: CCO:C0001313 name: nuclear proteasome core complex, beta-subunit complex namespace: cellular_component def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] xref: GO:0031607 is_a: CCO:C0001847 ! nuclear part is_a: CCO:C0002084 ! proteasome core complex, beta-subunit complex relationship: part_of CCO:C0001307 ! nuclear proteasome core complex [Term] id: CCO:C0001314 name: ER proteasome core complex, beta-subunit complex namespace: cellular_component def: "The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] xref: GO:0031608 is_a: CCO:C0001851 ! endoplasmic reticulum part is_a: CCO:C0002084 ! proteasome core complex, beta-subunit complex relationship: part_of CCO:C0001308 ! ER proteasome core complex [Term] id: CCO:C0001316 name: nuclear proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] xref: GO:0031610 is_a: CCO:C0001847 ! nuclear part is_a: CCO:C0002081 ! proteasome regulatory particle, base subcomplex relationship: part_of CCO:C0001304 ! nuclear proteasome regulatory particle [Term] id: CCO:C0001317 name: ER proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] xref: GO:0031611 is_a: CCO:C0001851 ! endoplasmic reticulum part is_a: CCO:C0002081 ! proteasome regulatory particle, base subcomplex relationship: part_of CCO:C0001305 ! ER proteasome regulatory particle [Term] id: CCO:C0001319 name: nuclear proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah] xref: GO:0031613 is_a: CCO:C0001847 ! nuclear part is_a: CCO:C0002082 ! proteasome regulatory particle, lid subcomplex relationship: part_of CCO:C0001304 ! nuclear proteasome regulatory particle [Term] id: CCO:C0001320 name: ER proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] xref: GO:0031614 is_a: CCO:C0001851 ! endoplasmic reticulum part is_a: CCO:C0002082 ! proteasome regulatory particle, lid subcomplex relationship: part_of CCO:C0001305 ! ER proteasome regulatory particle [Term] id: CCO:C0001322 name: spindle pole centrosome namespace: cellular_component def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah] xref: GO:0031616 is_a: CCO:C0000383 ! centrosome relationship: location_of CCO:B0013133 ! NDE1_HUMAN-Phosphoserine306 relationship: part_of CCO:C0000144 ! spindle pole [Term] id: CCO:C0001323 name: NMS complex namespace: cellular_component def: "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes." [PMID:16079914] synonym: "Ndc80-MIND-Spc7 complex" EXACT [] xref: GO:0031617 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000103 ! kinetochore [Term] id: CCO:C0001324 name: nuclear centric heterochromatin namespace: cellular_component def: "A region of heterochromatin located near the centromere of a chromosome in the nucleus." [GOC:mah] xref: GO:0031618 is_a: CCO:C0000310 ! nuclear heterochromatin is_a: CCO:C0000311 ! centric heterochromatin [Term] id: CCO:C0001325 name: xanthophore namespace: cellular_component def: "A chromatophore containing yellow pigment." [ISBN:0395825172] comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells. xref: GO:0031633 is_a: CCO:C0001688 ! chromatophore [Term] id: CCO:C0001326 name: A band namespace: cellular_component def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131] synonym: "A disc" EXACT [] synonym: "anisotropic disc" EXACT [] synonym: "Q disc" EXACT [] synonym: "transverse disc" EXACT [] xref: GO:0031672 is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0000933 ! sarcomere [Term] id: CCO:C0001327 name: H zone namespace: cellular_component def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131] synonym: "H band" EXACT [] synonym: "H disc" EXACT [] xref: GO:0031673 is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0001326 ! A band [Term] id: CCO:C0001328 name: I band namespace: cellular_component def: "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] synonym: "I disc" EXACT [] synonym: "isotropic disc" EXACT [] synonym: "J disc" EXACT [] xref: GO:0031674 is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0000933 ! sarcomere [Term] id: CCO:C0001330 name: plasma membrane-derived thylakoid membrane namespace: cellular_component def: "The pigmented membrane of a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane thylakoid membrane" EXACT [] synonym: "thylakoid membrane (sensu Cyanobacteria)" EXACT [] xref: GO:0031676 is_a: CCO:C0001684 ! thylakoid membrane is_a: CCO:C0001852 ! cytoplasmic vesicle part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000942 ! plasma membrane-derived thylakoid [Term] id: CCO:C0001333 name: G-protein beta/gamma-subunit complex namespace: cellular_component def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah] comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. synonym: "G-beta/G-gamma complex" EXACT [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] xref: GO:0031680 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001334 name: haptoglobin-hemoglobin complex namespace: cellular_component def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah] xref: GO:0031838 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0001335 name: Tic complex namespace: cellular_component def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016] synonym: "chloroplast inner membrane translocase complex" EXACT [] xref: GO:0031897 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000694 ! chloroplast inner membrane [Term] id: CCO:C0001336 name: chromoplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz] xref: GO:0031898 is_a: CCO:C0000654 ! plastid envelope relationship: part_of CCO:C0000638 ! chromoplast [Term] id: CCO:C0001337 name: chromoplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz] xref: GO:0031899 is_a: CCO:C0000656 ! plastid inner membrane is_a: CCO:C0001976 ! chromoplast membrane [Term] id: CCO:C0001338 name: chromoplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz] xref: GO:0031900 is_a: CCO:C0000655 ! plastid outer membrane is_a: CCO:C0001976 ! chromoplast membrane [Term] id: CCO:C0001339 name: early endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an early endosome." [GOC:pz] xref: GO:0031901 is_a: CCO:C0000713 ! endosome membrane relationship: location_of CCO:B0001980 ! DP13B_HUMAN relationship: location_of CCO:B0011567 ! DP13A_HUMAN-Phosphoserine691 relationship: part_of CCO:C0000352 ! early endosome [Term] id: CCO:C0001340 name: late endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a late endosome." [GOC:pz] xref: GO:0031902 is_a: CCO:C0000713 ! endosome membrane relationship: part_of CCO:C0000353 ! late endosome [Term] id: CCO:C0001341 name: microbody membrane namespace: cellular_component def: "The lipid bilayer surrounding a microbody." [GOC:mah] xref: GO:0031903 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001652 ! microbody [Term] id: CCO:C0001342 name: endosome lumen namespace: cellular_component def: "The volume enclosed by the membranes of an endosome." [GOC:mah] xref: GO:0031904 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001859 ! endosomal part [Term] id: CCO:C0001343 name: early endosome lumen namespace: cellular_component def: "The volume enclosed by the membranes of an early endosome." [GOC:mah] xref: GO:0031905 is_a: CCO:C0001342 ! endosome lumen relationship: part_of CCO:C0000352 ! early endosome [Term] id: CCO:C0001344 name: late endosome lumen namespace: cellular_component def: "The volume enclosed by the membranes of a late endosome." [GOC:mah] xref: GO:0031906 is_a: CCO:C0001342 ! endosome lumen relationship: part_of CCO:C0000353 ! late endosome [Term] id: CCO:C0001345 name: microbody lumen namespace: cellular_component def: "The volume enclosed by the membranes of a microbody." [GOC:mah] xref: GO:0031907 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001857 ! microbody part [Term] id: CCO:C0001346 name: glyoxysomal lumen namespace: cellular_component def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah] xref: GO:0031908 is_a: CCO:C0001345 ! microbody lumen relationship: part_of CCO:C0000643 ! glyoxysome [Term] id: CCO:C0001347 name: peroxisomal lumen namespace: cellular_component def: "The volume enclosed by the membranes of a peroxisome." [GOC:mah] xref: GO:0031909 is_a: CCO:C0001345 ! microbody lumen is_a: CCO:C0001858 ! peroxisomal part [Term] id: CCO:C0001348 name: cytostome namespace: cellular_component def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189] xref: GO:0031910 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001349 name: cytoproct namespace: cellular_component def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189] xref: GO:0031911 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001350 name: oral apparatus namespace: cellular_component def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189] comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals. xref: GO:0031912 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0001351 name: contractile vacuole pore namespace: cellular_component def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189] xref: GO:0031913 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001856 ! vacuolar part is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000442 ! actin filament relationship: part_of CCO:C0001138 ! contractile vacuolar membrane [Term] id: CCO:C0001354 name: telomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah] xref: GO:0031933 is_a: CCO:C0000119 ! heterochromatin [Term] id: CCO:C0001355 name: mating-type region heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah] xref: GO:0031934 is_a: CCO:C0000119 ! heterochromatin [Term] id: CCO:C0001356 name: filamentous actin namespace: cellular_component def: "A two-stranded helical polymer of the protein actin." [GOC:mah] comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'. synonym: "F-actin" EXACT [] xref: GO:0031941 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001849 ! cytoskeletal part relationship: location_of CCO:B0002257 ! CD2AP_HUMAN relationship: part_of CCO:C0000442 ! actin filament [Term] id: CCO:C0001357 name: i-AAA complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274] xref: GO:0031942 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0001358 name: nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] xref: GO:0031965 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001847 ! nuclear part relationship: part_of CCO:C0000253 ! nuclear envelope [Term] id: CCO:C0001359 name: mitochondrial membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah] xref: GO:0031966 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000326 ! mitochondrial envelope [Term] id: CCO:C0001360 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: gosubset_prok xref: GO:0031967 is_a: CCO:C0001367 ! envelope is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0002127 ! membrane-bounded organelle [Term] id: CCO:C0001361 name: organelle outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of an organelle envelope." [GOC:mah] xref: GO:0031968 is_a: CCO:C0000898 ! outer membrane is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0001360 ! organelle envelope [Term] id: CCO:C0001362 name: chloroplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz] xref: GO:0031969 is_a: CCO:C0001634 ! plastid membrane is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000708 ! chloroplast envelope [Term] id: CCO:C0001363 name: organelle envelope lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah] synonym: "organelle intermembrane space" EXACT [] xref: GO:0031970 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0001360 ! organelle envelope [Term] id: CCO:C0001364 name: chloroplast intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah] synonym: "chloroplast envelope lumen" EXACT [] xref: GO:0031972 is_a: CCO:C0000657 ! plastid intermembrane space is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000708 ! chloroplast envelope [Term] id: CCO:C0001365 name: chromoplast intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah] synonym: "chromoplast envelope lumen" EXACT [] xref: GO:0031973 is_a: CCO:C0000657 ! plastid intermembrane space relationship: part_of CCO:C0001336 ! chromoplast envelope [Term] id: CCO:C0001366 name: membrane-enclosed lumen namespace: cellular_component def: "The enclosed volume within a sealed membrane or between two sealed membranes." [GOC:add] xref: GO:0031974 is_a: CCO:C0000200 ! cellular_component [Term] id: CCO:C0001367 name: envelope namespace: cellular_component def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer, also includes the space between layers." [GOC:mah, GOC:pz] subset: gosubset_prok xref: GO:0031975 is_a: CCO:C0000200 ! cellular_component [Term] id: CCO:C0001368 name: plastid thylakoid namespace: cellular_component def: "Any thylakoid within a plastid." [GOC:pz] xref: GO:0031976 is_a: CCO:C0000689 ! thylakoid is_a: CCO:C0001376 ! organelle subcompartment is_a: CCO:C0001854 ! plastid part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0001369 name: thylakoid lumen namespace: cellular_component def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz] xref: GO:0031977 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001855 ! thylakoid part [Term] id: CCO:C0001370 name: plastid thylakoid lumen namespace: cellular_component def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah] xref: GO:0031978 is_a: CCO:C0001369 ! thylakoid lumen is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0001368 ! plastid thylakoid [Term] id: CCO:C0001371 name: plasma membrane-derived thylakoid lumen namespace: cellular_component def: "The volume enclosed by a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane thylakoid lumen" EXACT [] synonym: "thylakoid lumen (sensu Cyanobacteria)" EXACT [] xref: GO:0031979 is_a: CCO:C0001369 ! thylakoid lumen is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0002132 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of CCO:C0000942 ! plasma membrane-derived thylakoid [Term] id: CCO:C0001372 name: mitochondrial lumen namespace: cellular_component def: "The volume enclosed by the mitochondrial inner membrane." [GOC:mah, GOC:pz] xref: GO:0031980 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001848 ! mitochondrial part [Term] id: CCO:C0001373 name: nuclear lumen namespace: cellular_component def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] xref: GO:0031981 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001374 name: vesicle namespace: cellular_component def: "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] subset: goslim_pir subset: gosubset_prok xref: GO:0031982 is_a: CCO:C0001742 ! organelle [Term] id: CCO:C0001375 name: vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah] xref: GO:0031983 is_a: CCO:C0001749 ! organelle lumen relationship: part_of CCO:C0002125 ! membrane-bounded vesicle [Term] id: CCO:C0001376 name: organelle subcompartment namespace: cellular_component def: "A membrane-enclosed compartment that is a part of an organelle." [GOC:pz] synonym: "suborganelle compartment" EXACT [] xref: GO:0031984 is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0002127 ! membrane-bounded organelle [Term] id: CCO:C0001377 name: Golgi cisterna namespace: cellular_component def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah] xref: GO:0031985 is_a: CCO:C0000376 ! Golgi stack is_a: CCO:C0001376 ! organelle subcompartment [Term] id: CCO:C0001378 name: proteinoplast namespace: cellular_component def: "A leucoplast in which protein is stored." [GOC:pz] xref: GO:0031986 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0001380 name: interleukin-28 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-28 and interleukin-29. Composed of two subunits, IL-28R alpha and IL-10R beta." [GOC:rh2] xref: GO:0032002 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001381 name: early phagosome namespace: cellular_component def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753] synonym: "early phagocytic vesicle" EXACT [] xref: GO:0032009 is_a: CCO:C0001950 ! phagocytic vesicle [Term] id: CCO:C0001382 name: phagolysosome namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753] synonym: "late phagocytic vesicle" RELATED [] synonym: "late phagosome" RELATED [] xref: GO:0032010 is_a: CCO:C0000350 ! secondary lysosome is_a: CCO:C0001950 ! phagocytic vesicle [Term] id: CCO:C0001383 name: mitochondrial cloud namespace: cellular_component def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166] synonym: "Balbiani body" EXACT [] xref: GO:0032019 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle [Term] id: CCO:C0001384 name: NELF complex namespace: cellular_component def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062] synonym: "negative elongation factor complex" EXACT [] xref: GO:0032021 is_a: CCO:C0000523 ! transcription elongation factor complex [Term] id: CCO:C0001385 name: integrator complex namespace: cellular_component def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144] xref: GO:0032039 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0001386 name: small subunit processome namespace: cellular_component def: "A large ribonuclear protein complex containing the U3 snoRNA and associated proteins (28 in S. cerevisiae) that is involved in processing of the pre-18S rRNA to form the small ribosomal subunit." [PMID:12068309] synonym: "SSU processome" EXACT [] xref: GO:0032040 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001871 ! nucleolar part [Term] id: CCO:C0001387 name: DSIF complex namespace: cellular_component def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788] synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT [] synonym: "DRB sensitivity inducing factor complex" EXACT [] synonym: "Spt4-Spt5 complex" EXACT [] xref: GO:0032044 is_a: CCO:C0000523 ! transcription elongation factor complex [Term] id: CCO:C0001388 name: guanyl-nucleotide exchange factor complex namespace: cellular_component def: "A protein complex that stimulates the exchange of guanyl nucleotides by a GTPase." [GOC:mah] xref: GO:0032045 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001389 name: micropexophagy-specific membrane apparatus namespace: cellular_component def: "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611] synonym: "micropexophagic apparatus" EXACT [] synonym: "MIPA" EXACT [] xref: GO:0032046 is_a: CCO:C0001376 ! organelle subcompartment is_a: CCO:C0001856 ! vacuolar part [Term] id: CCO:C0001390 name: mitosome namespace: cellular_component def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria." [PMID:10361303, PMID:14614504] synonym: "crypton" EXACT [] xref: GO:0032047 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0001391 name: bleb namespace: cellular_component def: "A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions." [PMID:12083798, PMID:16624291] subset: goslim_pir xref: GO:0032059 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0001392 name: Type IV site-specific deoxyribonuclease complex namespace: cellular_component def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995] synonym: "Type IV restriction enzyme complex" EXACT [] xref: GO:0032068 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001393 name: cohesin loading complex namespace: cellular_component def: "A complex required for the loading of cohesin onto DNA prior to the establishment of cohesion. Appears to be eukaryotically conserved." [GOC:vw, PMID:10882066] xref: GO:0032116 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001394 name: horsetail-astral microtubule array namespace: cellular_component def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942] synonym: "HAA" EXACT [] xref: GO:0032117 is_a: CCO:C0000387 ! aster [Term] id: CCO:C0001395 name: deep fiber namespace: cellular_component def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189] synonym: "deep fibre" EXACT [] xref: GO:0032123 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0001350 ! oral apparatus [Term] id: CCO:C0001396 name: eisosome namespace: cellular_component def: "Any of the large immobile protein assemblies at the plasma membrane that mark endocytic sites. In yeast, S. cerevisiae, these structures are primarily composed of Pil1p and Lsp1p." [PMID:16496001] xref: GO:0032126 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001867 ! cell cortex part [Term] id: CCO:C0001397 name: dense core granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] xref: GO:0032127 is_a: CCO:C0001031 ! secretory granule membrane relationship: part_of CCO:C0001118 ! dense core granule [Term] id: CCO:C0001398 name: chromosome passenger complex namespace: cellular_component def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger comples coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain containing protein survivin, aurora kinase and INCENP." [GOC:vw, PMID:16824200] xref: GO:0032133 is_a: CCO:C0000435 ! microtubule associated complex [Term] id: CCO:C0001399 name: 4-aminobutyrate transaminase complex namespace: cellular_component def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998] synonym: "ABAT complex" EXACT [] synonym: "GABA transaminase complex" EXACT [] synonym: "GABA-T complex" EXACT [] xref: GO:0032144 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001400 name: mitotic septin complex namespace: cellular_component def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555] xref: GO:0032151 is_a: CCO:C0001135 ! septin complex [Term] id: CCO:C0001401 name: meiotic septin complex namespace: cellular_component def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555] xref: GO:0032152 is_a: CCO:C0001135 ! septin complex [Term] id: CCO:C0001402 name: cell division site namespace: cellular_component def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. The cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane. The mitotic, or meiotic, spindle is aligned perpendicular to the division plane." [GOC:krc, GOC:ns, PMID:12101122, PMID:15380095] subset: goslim_pir synonym: "cell division plane" EXACT [] xref: GO:0032153 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001403 name: cleavage furrow namespace: cellular_component def: "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin, is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] xref: GO:0032154 is_a: CCO:C0001404 ! cell division site part relationship: location_of CCO:B0035935 ! MEN1_HUMAN relationship: location_of CCO:B0036017 ! MYH10_HUMAN-Phosphothreonine1376 [Term] id: CCO:C0001404 name: cell division site part namespace: cellular_component def: "Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah] synonym: "cell division plane part" EXACT [] xref: GO:0032155 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0001402 ! cell division site [Term] id: CCO:C0001405 name: septin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah] xref: GO:0032156 is_a: CCO:C0000421 ! cytoskeleton [Term] id: CCO:C0001406 name: prospore contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555] synonym: "actomyosin ring (sensu Saccharomyces)" BROAD [] synonym: "cytokinetic ring (sensu Saccharomyces)" BROAD [] synonym: "meiotic contractile ring" RELATED [] xref: GO:0032157 is_a: CCO:C0000394 ! contractile ring relationship: part_of CCO:C0002135 ! ascospore-type prospore [Term] id: CCO:C0001407 name: septin band namespace: cellular_component def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244] xref: GO:0032158 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0001405 ! septin cytoskeleton [Term] id: CCO:C0001408 name: septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentiously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] xref: GO:0032159 is_a: CCO:C0001405 ! septin cytoskeleton is_a: CCO:C0001849 ! cytoskeletal part [Term] id: CCO:C0001409 name: septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244] synonym: "septin bar" RELATED [] xref: GO:0032160 is_a: CCO:C0001405 ! septin cytoskeleton is_a: CCO:C0001849 ! cytoskeletal part [Term] id: CCO:C0001410 name: cleavage apparatus septin structure namespace: cellular_component def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555] xref: GO:0032161 is_a: CCO:C0001404 ! cell division site part is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000489 ! cell cortex relationship: part_of CCO:C0001405 ! septin cytoskeleton [Term] id: CCO:C0001411 name: mating projection septin band namespace: cellular_component def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244] xref: GO:0032162 is_a: CCO:C0001407 ! septin band [Term] id: CCO:C0001412 name: hyphal septin band namespace: cellular_component def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:16151244, GOC:krc, GOC:mah] xref: GO:0032163 is_a: CCO:C0001407 ! septin band [Term] id: CCO:C0001413 name: hyphal septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentiously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] xref: GO:0032164 is_a: CCO:C0001408 ! septin cap [Term] id: CCO:C0001414 name: prospore septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244] xref: GO:0032165 is_a: CCO:C0001409 ! septin filament array [Term] id: CCO:C0001415 name: chlamydospore septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244] xref: GO:0032166 is_a: CCO:C0001409 ! septin filament array [Term] id: CCO:C0001416 name: hyphal septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] xref: GO:0032168 is_a: CCO:C0000490 ! septin ring [Term] id: CCO:C0001417 name: prospore septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] xref: GO:0032169 is_a: CCO:C0000490 ! septin ring is_a: CCO:C0001410 ! cleavage apparatus septin structure relationship: part_of CCO:C0002135 ! ascospore-type prospore [Term] id: CCO:C0001418 name: pseudohyphal septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] xref: GO:0032170 is_a: CCO:C0000490 ! septin ring [Term] id: CCO:C0001419 name: germ tube septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentiously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] xref: GO:0032171 is_a: CCO:C0001408 ! septin cap [Term] id: CCO:C0001420 name: germ tube septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244] xref: GO:0032172 is_a: CCO:C0000490 ! septin ring relationship: part_of CCO:C0001427 ! germ tube [Term] id: CCO:C0001421 name: septin collar namespace: cellular_component def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244] xref: GO:0032173 is_a: CCO:C0001405 ! septin cytoskeleton is_a: CCO:C0001849 ! cytoskeletal part [Term] id: CCO:C0001422 name: cellular bud neck septin collar namespace: cellular_component def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555] xref: GO:0032174 is_a: CCO:C0000076 ! cellular bud neck septin structure is_a: CCO:C0001410 ! cleavage apparatus septin structure is_a: CCO:C0001421 ! septin collar [Term] id: CCO:C0001423 name: mating projection septin ring namespace: cellular_component def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244] xref: GO:0032175 is_a: CCO:C0000490 ! septin ring [Term] id: CCO:C0001424 name: split septin rings namespace: cellular_component def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244] xref: GO:0032176 is_a: CCO:C0001405 ! septin cytoskeleton is_a: CCO:C0001849 ! cytoskeletal part [Term] id: CCO:C0001425 name: cellular bud neck split septin rings namespace: cellular_component def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555] xref: GO:0032177 is_a: CCO:C0000076 ! cellular bud neck septin structure is_a: CCO:C0001410 ! cleavage apparatus septin structure is_a: CCO:C0001424 ! split septin rings [Term] id: CCO:C0001426 name: medial membrane band namespace: cellular_component def: "A sterol rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003] synonym: "sterol-rich membrane band" RELATED [] xref: GO:0032178 is_a: CCO:C0001404 ! cell division site part [Term] id: CCO:C0001427 name: germ tube namespace: cellular_component def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148] subset: goslim_pir xref: GO:0032179 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001428 name: post-lysosomal vacuole namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:9276759, PMID:9394012] xref: GO:0032195 is_a: CCO:C0000355 ! vacuole is_a: CCO:C0000983 ! endocytic vesicle [Term] id: CCO:C0001429 name: Clr6 histone deacetylase complex II' namespace: cellular_component def: "A eukaryotically conserved histone deacetylse complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151] xref: GO:0032221 is_a: CCO:C0000008 ! histone deacetylase complex [Term] id: CCO:C0001430 name: asymmetric synapse namespace: cellular_component def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density." [GOC:dgh, GOC:ef] xref: GO:0032279 is_a: CCO:C0001900 ! synapse [Term] id: CCO:C0001431 name: symmetric synapse namespace: cellular_component def: "A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density." [GOC:dgh, GOC:ef] xref: GO:0032280 is_a: CCO:C0001900 ! synapse [Term] id: CCO:C0001432 name: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef] synonym: "AMPA receptor " RELATED [] synonym: "AMPA-selective glutamate receptor complex" EXACT [] xref: GO:0032281 is_a: CCO:C0000545 ! ionotropic glutamate receptor complex [Term] id: CCO:C0001433 name: plastid acetyl-CoA carboxylase complex namespace: cellular_component def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah] synonym: "plastid ACCase complex" EXACT [] xref: GO:0032282 is_a: CCO:C0000565 ! acetyl-CoA carboxylase complex is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000660 ! plastid stroma [Term] id: CCO:C0001434 name: plastid acetate CoA-transferase complex namespace: cellular_component def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah] xref: GO:0032283 is_a: CCO:C0000577 ! acetate CoA-transferase complex relationship: part_of CCO:C0001433 ! plastid acetyl-CoA carboxylase complex [Term] id: CCO:C0001435 name: plastid biotin carboxylase complex namespace: cellular_component def: "A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah] xref: GO:0032284 is_a: CCO:C0000590 ! biotin carboxylase complex relationship: part_of CCO:C0001433 ! plastid acetyl-CoA carboxylase complex [Term] id: CCO:C0001436 name: ribonuclease H2 complex namespace: cellular_component def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815] synonym: "RNase H2 complex" EXACT [] xref: GO:0032299 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001437 name: mismatch repair complex namespace: cellular_component def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah] subset: goslim_pir xref: GO:0032300 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001438 name: MutSalpha complex namespace: cellular_component def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803] synonym: "MMR complex" BROAD [] synonym: "MSH2/MSH6 complex" EXACT [] xref: GO:0032301 is_a: CCO:C0001437 ! mismatch repair complex relationship: location_of CCO:B0013014 ! MSH2_HUMAN-Phosphoserine860 [Term] id: CCO:C0001439 name: MutSbeta complex namespace: cellular_component def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803] synonym: "MMR complex" BROAD [] synonym: "MSH2/MSH3 complex" EXACT [] xref: GO:0032302 is_a: CCO:C0001437 ! mismatch repair complex relationship: location_of CCO:B0013014 ! MSH2_HUMAN-Phosphoserine860 [Term] id: CCO:C0001440 name: angiogenin-PRI complex namespace: cellular_component def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787] synonym: "angiogenin-placental ribonuclease inhibitor complex" EXACT [] xref: GO:0032311 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part [Term] id: CCO:C0001441 name: MutLalpha complex namespace: cellular_component def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk] synonym: "MLH1/PMS2 complex" EXACT [] synonym: "MMR complex" BROAD [] xref: GO:0032389 is_a: CCO:C0001437 ! mismatch repair complex [Term] id: CCO:C0001442 name: MutLbeta complex namespace: cellular_component def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk] synonym: "MLH1/PMS1 complex" EXACT [] synonym: "MMR complex" BROAD [] xref: GO:0032390 is_a: CCO:C0001437 ! mismatch repair complex [Term] id: CCO:C0001443 name: photoreceptor connecting cilium namespace: cellular_component def: "A 9+0 cilium that forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments." [PMID:15917207, PMID:8718680] synonym: "photoreceptor cilium" RELATED [] xref: GO:0032391 is_a: CCO:C0001281 ! nonmotile primary cilium [Term] id: CCO:C0001444 name: MHC class Ib protein complex namespace: cellular_component def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15928678] xref: GO:0032398 is_a: CCO:C0001668 ! MHC protein complex [Term] id: CCO:C0001445 name: extrinsic to lysosome membrane namespace: cellular_component def: "Loosely bound to one surface of the lysosome membrane, but not integrated into the hydrophobic region." [GOC:mah] synonym: "extrinsic to lysosomal membrane" EXACT [] xref: GO:0032419 is_a: CCO:C0000052 ! extrinsic to vacuolar membrane relationship: part_of CCO:C0000348 ! lysosomal membrane [Term] id: CCO:C0001446 name: stereocilium namespace: cellular_component def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137] xref: GO:0032420 is_a: CCO:C0000459 ! microvillus relationship: part_of CCO:C0001447 ! stereocilium bundle [Term] id: CCO:C0001447 name: stereocilium bundle namespace: cellular_component def: "An actin-based, cross-linked cellular protrusion on the apical surface of auditory and vestibular hair cells. Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137] subset: goslim_pir synonym: "stereocilia bundle" EXACT [] xref: GO:0032421 is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle [Term] id: CCO:C0001448 name: stereocilium bundle tip namespace: cellular_component def: "The end of a stereocilium bundle, distal to the site of the bundle's attachment to the apical cell surface." [GOC:ecd, PMID:17021180] synonym: "stereocilium tip" RELATED [] xref: GO:0032426 is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0001447 ! stereocilium bundle [Term] id: CCO:C0001449 name: actin filament bundle namespace: cellular_component def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] xref: GO:0032432 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0001450 name: filopodium tip namespace: cellular_component def: "The end of a filopodium distal to the body of the cell." [GOC:mah] xref: GO:0032433 is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0000989 ! filopodium [Term] id: CCO:C0001451 name: cuticular plate namespace: cellular_component def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151] xref: GO:0032437 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0001056 ! cortical actin cytoskeleton [Term] id: CCO:C0001452 name: activin responsive factor complex namespace: cellular_component def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972] comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor). synonym: "ARF complex" EXACT [] xref: GO:0032444 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0001453 name: CBM complex namespace: cellular_component def: "A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation." [PMID:12909454] synonym: "CARMA1-BCL10-Malt1 complex" EXACT [] xref: GO:0032449 is_a: CCO:C0001750 ! protein complex relationship: location_of CCO:B0001458 ! BCL10_HUMAN [Term] id: CCO:C0001454 name: external side of mitochondrial outer membrane namespace: cellular_component def: "The external (cytoplasmic face) of the mitochondrial outer membrane." [GOC:mah] synonym: "cytosolic side of mitochondrial outer membrane" EXACT [] synonym: "external side of mitochondrial envelope" RELATED [] xref: GO:0032473 is_a: CCO:C0001874 ! mitochondrial membrane part [Term] id: CCO:C0001455 name: decaprenyl diphosphate synthase complex namespace: cellular_component def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123] subset: goslim_pir xref: GO:0032476 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0001456 name: homodimeric decaprenyl diphosphate synthase complex namespace: cellular_component def: "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [PMID:14519123] xref: GO:0032477 is_a: CCO:C0001455 ! decaprenyl diphosphate synthase complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001457 name: heterotetrameric decaprenyl diphosphate synthase complex namespace: cellular_component def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123] xref: GO:0032478 is_a: CCO:C0001455 ! decaprenyl diphosphate synthase complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0001458 name: SOD1-calcineurin complex namespace: cellular_component def: "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1." [GOC:mah, PMID:17324120] xref: GO:0032517 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001459 name: cortical endoplasmic reticulum namespace: cellular_component def: "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements." [GOC:se, PMID:10931860, PMID:17686782] synonym: "cortical ER" EXACT [] synonym: "peripheral endoplasmic reticulum" EXACT [] synonym: "peripheral ER" EXACT [] xref: GO:0032541 is_a: CCO:C0001851 ! endoplasmic reticulum part [Term] id: CCO:C0001460 name: CURI complex namespace: cellular_component def: "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p andIfh1p." [PMID:17452446] xref: GO:0032545 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001461 name: aleurone grain membrane namespace: cellular_component def: "The lipid bilayer surrounding an aleurone grain." [GOC:ecd] xref: GO:0032578 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0001516 ! aleurone grain [Term] id: CCO:C0001462 name: apical lamina of hyaline layer namespace: cellular_component def: "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms." [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331] xref: GO:0032579 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001541 ! hyaline layer [Term] id: CCO:C0001463 name: Golgi cisterna membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah] synonym: "Golgi stack membrane" EXACT [] xref: GO:0032580 is_a: CCO:C0000021 ! Golgi membrane relationship: part_of CCO:C0001377 ! Golgi cisterna [Term] id: CCO:C0001464 name: growth cone membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a growth cone." [GOC:mah] xref: GO:0032584 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0001006 ! growth cone [Term] id: CCO:C0001465 name: multivesicular body membrane namespace: cellular_component def: "The lipid bilayer surrounding a multivesicular body." [GOC:mah] synonym: "multivesicular endosome membrane" EXACT [] synonym: "MVB membrane" EXACT [] synonym: "MVE membrane" EXACT [] xref: GO:0032585 is_a: CCO:C0001340 ! late endosome membrane relationship: part_of CCO:C0000354 ! multivesicular body [Term] id: CCO:C0001466 name: protein storage vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a protein storage vacuole." [GOC:mah] xref: GO:0032586 is_a: CCO:C0002159 ! plant-type vacuole membrane [Term] id: CCO:C0001467 name: ruffle membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a ruffle." [GOC:mah] synonym: "membrane ruffle" RELATED [] xref: GO:0032587 is_a: CCO:C0001173 ! cell projection membrane is_a: CCO:C0001176 ! leading edge membrane relationship: part_of CCO:C0000181 ! ruffle [Term] id: CCO:C0001468 name: trans-Golgi network membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah] synonym: "Golgi trans face membrane" RELATED [] synonym: "trans Golgi network membrane" EXACT [] xref: GO:0032588 is_a: CCO:C0000021 ! Golgi membrane relationship: part_of CCO:C0000381 ! trans-Golgi network [Term] id: CCO:C0001469 name: neuron projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah] xref: GO:0032589 is_a: CCO:C0001173 ! cell projection membrane is_a: CCO:C0001176 ! leading edge membrane relationship: part_of CCO:C0001707 ! neuron projection [Term] id: CCO:C0001470 name: dendrite membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah] xref: GO:0032590 is_a: CCO:C0001469 ! neuron projection membrane [Term] id: CCO:C0001471 name: dendritic spine membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendritic spine." [GOC:mah] xref: GO:0032591 is_a: CCO:C0001469 ! neuron projection membrane relationship: part_of CCO:C0001729 ! dendritic spine [Term] id: CCO:C0001472 name: integral to mitochondrial membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] xref: GO:0032592 is_a: CCO:C0001152 ! intrinsic to Golgi membrane is_a: CCO:C0001188 ! integral to organelle membrane [Term] id: CCO:C0001473 name: insulin-responsive compartment namespace: cellular_component def: "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2." [PMID:17644329] synonym: "GLUT4 storage compartment" EXACT [] synonym: "GSC" RELATED [] synonym: "IRC" RELATED [] xref: GO:0032593 is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001474 name: NHE3/E3KARP/ACTN4 complex namespace: cellular_component def: "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments." [PMID:11948184] synonym: " NHE3/E3KARP/alpha-actinin complex" EXACT [] xref: GO:0032766 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001475 name: Piccolo NuA4 histone acetyltransferase complex namespace: cellular_component def: "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [PMID:12782659, PMID:15964809] xref: GO:0032777 is_a: CCO:C0001724 ! H4/H2A histone acetyltransferase complex [Term] id: CCO:C0001476 name: ELL-EAF complex namespace: cellular_component def: "A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956] xref: GO:0032783 is_a: CCO:C0000523 ! transcription elongation factor complex [Term] id: CCO:C0001477 name: SMN complex namespace: cellular_component def: "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] synonym: "survival motor neuron complex" EXACT [] xref: GO:0032797 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001478 name: Swi5-Sfr1 complex namespace: cellular_component def: "A conserved eukaryotic protein complex involved in DNA recombination repair; in Schizosaccharomyces the complex contains two Swi5 monomers and one Sfr1 monomer." [PMID:16921379] synonym: "Swi5 complex" BROAD [] xref: GO:0032798 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001479 name: carboxy-terminal domain protein kinase complex namespace: cellular_component def: "A protein complex that phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats; in Saccharomyces the complex contains Ctk1p, Ctk2p, and Ctk3p." [PMID:15047695, PMID:16721054] synonym: "CTDK complex" EXACT [] synonym: "CTDK-1" NARROW [] xref: GO:0032806 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001480 name: DNA ligase IV complex namespace: cellular_component def: "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p." [PMID:16314503] xref: GO:0032807 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001481 name: cell soma membrane namespace: cellular_component def: "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections." [GOC:ecd] synonym: "cell body membrane" EXACT [] xref: GO:0032809 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0001709 ! cell soma [Term] id: CCO:C0001482 name: cell projection cytoplasm namespace: cellular_component def: "All of the contents of a cell projection, excluding the plasma membrane surrounding the projection." [GOC:mah] xref: GO:0032838 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001881 ! cell projection part [Term] id: CCO:C0001483 name: dendrite cytoplasm namespace: cellular_component def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah] synonym: "dendritic cytoplasm" EXACT [] xref: GO:0032839 is_a: CCO:C0001482 ! cell projection cytoplasm relationship: part_of CCO:C0001005 ! dendrite [Term] id: CCO:C0001484 name: cytochrome bc(1) complex namespace: cellular_component def: "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733] synonym: "complex III" EXACT [] synonym: "cytochrome bc1 complex" EXACT [] xref: GO:0032842 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part [Term] id: CCO:C0001485 name: Mdm10/Mdm12/Mmm1 complex namespace: cellular_component def: "A protein complex that links mtDNA and mitochondrial outer and inner membranes to the cytoskeletal system." [PMID:13679517] xref: GO:0032865 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000327 ! mitochondrial outer membrane [Term] id: CCO:C0001486 name: sarcosine oxidase complex namespace: cellular_component def: "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity." [GOC:mah, GOC:mlg] xref: GO:0032921 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001487 name: SREBP-SCAP complex namespace: cellular_component def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed." [PMID:12923525] synonym: "Sre1-Scp1 complex" EXACT [] xref: GO:0032936 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part [Term] id: CCO:C0001488 name: SREBP-SCAP-Insig complex namespace: cellular_component def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane." [PMID:12923525] xref: GO:0032937 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0000990 ! integral to endoplasmic reticulum membrane [Term] id: CCO:C0001489 name: endosomal scaffold complex namespace: cellular_component def: "A complex in eukaryotic cells containing Mapbpip (p14,Rab25) and Map2k1ip1 (MP1). The complex anchors on late endosomes and is involved in activating ERK 1/2, key components in MAPK signaling." [PMID:15263099] xref: GO:0032969 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001859 ! endosomal part relationship: part_of CCO:C0001340 ! late endosome membrane [Term] id: CCO:C0001490 name: myosin filament namespace: cellular_component def: "A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah] synonym: "myosin thick filament" RELATED [] synonym: "thick filament" RELATED [] xref: GO:0032982 is_a: CCO:C0000788 ! myosin complex [Term] id: CCO:C0001491 name: kainate selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluR5-7 and KA-1/2 subunits." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] xref: GO:0032983 is_a: CCO:C0000545 ! ionotropic glutamate receptor complex [Term] id: CCO:C0001492 name: macromolecular complex namespace: cellular_component def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "macromolecule complex" EXACT [] xref: GO:0032991 is_a: CCO:C0000200 ! cellular_component [Term] id: CCO:C0001493 name: protein-carbohydrate complex namespace: cellular_component def: "A macromolecular complex containing both protein and carbohydrate molecules." [GOC:mah] subset: gosubset_prok xref: GO:0032992 is_a: CCO:C0001492 ! macromolecular complex [Term] id: CCO:C0001494 name: protein-DNA complex namespace: cellular_component def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] subset: gosubset_prok xref: GO:0032993 is_a: CCO:C0001492 ! macromolecular complex [Term] id: CCO:C0001495 name: protein-lipid complex namespace: cellular_component def: "A macromolecular complex containing both protein and lipid molecules." [GOC:mah] subset: gosubset_prok xref: GO:0032994 is_a: CCO:C0001492 ! macromolecular complex [Term] id: CCO:C0001496 name: Bcl3-Bcl10 complex namespace: cellular_component def: "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327] xref: GO:0032996 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001497 name: Fc receptor complex namespace: cellular_component def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] subset: goslim_pir synonym: "FcR complex" EXACT [] synonym: "immunoglobulin receptor complex" BROAD [] xref: GO:0032997 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001498 name: Fc-epsilon receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "FceRI complex" EXACT [] synonym: "IgE receptor complex" BROAD [] synonym: "immunoglobulin E receptor complex" BROAD [] xref: GO:0032998 is_a: CCO:C0001497 ! Fc receptor complex [Term] id: CCO:C0001499 name: Fc-alpha receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12524384] synonym: "FcaRI complex" EXACT [] synonym: "IgA receptor complex" BROAD [] synonym: "immunoglobulin A receptor complex" BROAD [] xref: GO:0032999 is_a: CCO:C0001497 ! Fc receptor complex [Term] id: CCO:C0001500 name: Fc-gamma receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11244038, PMID:12413532] synonym: "FcgRI complex" EXACT [] synonym: "IgG receptor complex" BROAD [] synonym: "immunoglobulin G receptor complex" BROAD [] xref: GO:0033000 is_a: CCO:C0001497 ! Fc receptor complex [Term] id: CCO:C0001501 name: Fc-gamma receptor III complex namespace: cellular_component def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11244038, PMID:12413532] synonym: "FcgRIII complex" EXACT [] synonym: "IgG receptor complex" BROAD [] synonym: "immunoglobulin G receptor complex" BROAD [] xref: GO:0033001 is_a: CCO:C0001497 ! Fc receptor complex [Term] id: CCO:C0001502 name: nucleomorph namespace: cellular_component def: "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively." [PMID:16760254] xref: GO:0033009 is_a: CCO:C0001854 ! plastid part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0001503 name: paranodal junction namespace: cellular_component def: "A highly specialized junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [PMID:11395001, PMID:14630217] xref: GO:0033010 is_a: CCO:C0000463 ! intercellular junction [Term] id: CCO:C0001504 name: perinuclear theca namespace: cellular_component def: "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins." [PMID:17289678, PMID:8025156] xref: GO:0033011 is_a: CCO:C0000421 ! cytoskeleton relationship: part_of CCO:C0001996 ! perinuclear region of cytoplasm [Term] id: CCO:C0001505 name: porosome namespace: cellular_component def: "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles." [PMID:15090256, PMID:16563225] xref: GO:0033012 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001506 name: rhoptry membrane namespace: cellular_component def: "The lipid bilayer surrounding a rhoptry." [GOC:mah] xref: GO:0033016 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0000910 ! rhoptry [Term] id: CCO:C0001507 name: sarcoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph] xref: GO:0033017 is_a: CCO:C0000370 ! endoplasmic reticulum membrane relationship: part_of CCO:C0000802 ! sarcoplasmic reticulum [Term] id: CCO:C0001508 name: sarcoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph] xref: GO:0033018 is_a: CCO:C0000369 ! endoplasmic reticulum lumen relationship: part_of CCO:C0000802 ! sarcoplasmic reticulum [Term] id: CCO:C0001509 name: DNA recombinase mediator complex namespace: cellular_component def: "A protein complex containing two or more Rad51 paralogs and promotes nucleoprotein filament formation during homologous recombination." [GOC:elh, GOC:mah, GOC:vw] subset: goslim_pir xref: GO:0033061 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001510 name: Rhp55-Rhp57 complex namespace: cellular_component def: "A conserved heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces)." [GOC:mah, GOC:vw] synonym: "Rad55-Rad57 complex" EXACT [] xref: GO:0033062 is_a: CCO:C0001509 ! DNA recombinase mediator complex [Term] id: CCO:C0001511 name: Rad51B-Rad51C-Rad51D-XRCC2 complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "BCDX2 complex" EXACT [] xref: GO:0033063 is_a: CCO:C0001509 ! DNA recombinase mediator complex [Term] id: CCO:C0001512 name: XRCC2-RAD51D complex namespace: cellular_component def: "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast." [GOC:mah, GOC:vw, PMID:16093548] synonym: "DX2 complex" EXACT [] xref: GO:0033064 is_a: CCO:C0001509 ! DNA recombinase mediator complex [Term] id: CCO:C0001513 name: Rad51C-XRCC3 complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "CX3 complex" EXACT [] xref: GO:0033065 is_a: CCO:C0001509 ! DNA recombinase mediator complex [Term] id: CCO:C0001514 name: Rad51B-Rad51C complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "BC complex" EXACT [] xref: GO:0033066 is_a: CCO:C0001509 ! DNA recombinase mediator complex [Term] id: CCO:C0001515 name: Weibel-Palade body namespace: cellular_component def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708] xref: GO:0033093 is_a: CCO:C0000981 ! clathrin-coated vesicle is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001516 name: aleurone grain namespace: cellular_component def: "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes." [http://ejournal.sinica.edu.tw/bbas/content/2004/1/bot451-08.pdf, http://www.springerlink.com/content/q7183h5vr7358278/] synonym: "aleurone body" EXACT [] xref: GO:0033095 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0001517 name: amyloplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] xref: GO:0033096 is_a: CCO:C0000654 ! plastid envelope relationship: part_of CCO:C0000630 ! amyloplast [Term] id: CCO:C0001518 name: amyloplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope." [GOC:ecd] xref: GO:0033097 is_a: CCO:C0001634 ! plastid membrane relationship: part_of CCO:C0001517 ! amyloplast envelope [Term] id: CCO:C0001519 name: amyloplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma." [GOC:ecd] xref: GO:0033098 is_a: CCO:C0000656 ! plastid inner membrane is_a: CCO:C0001518 ! amyloplast membrane [Term] id: CCO:C0001520 name: attachment organelle namespace: cellular_component def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [http://authors.library.caltech.edu/3529/, PMID:11325545, PMID:12003948] subset: goslim_pir xref: GO:0033099 is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0001521 name: NuA3 histone acetyltransferase complex namespace: cellular_component def: "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p." [PMID:10817755, PMID:17157260] xref: GO:0033100 is_a: CCO:C0000011 ! histone acetyltransferase complex [Term] id: CCO:C0001522 name: cellular bud membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cellular bud." [GOC:mah] synonym: "cellular bud plasma membrane" EXACT [] xref: GO:0033101 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000485 ! cellular bud [Term] id: CCO:C0001523 name: acidocalcisome membrane namespace: cellular_component def: "The lipid bilayer surrounding an acidocalcisome." [GOC:ecd, PMID:11378195] xref: GO:0033102 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0000919 ! acidocalcisome [Term] id: CCO:C0001524 name: type VI protein secretion system complex namespace: cellular_component def: "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] subset: gosubset_prok synonym: "T6SS complex" EXACT [] xref: GO:0033104 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001525 name: chlorosome envelope namespace: cellular_component def: "The membrane-like structure, composed of glycolipids and proteins, that encloses the pigments and other contents of the chlorosome." [PMID:14507718, PMID:14729689] comment: Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'. synonym: "chlorosome membrane" EXACT [] xref: GO:0033105 is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0001972 ! chlorosome [Term] id: CCO:C0001526 name: cis-Golgi network membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." [GOC:mah] synonym: "cis Golgi network membrane" EXACT [] synonym: "Golgi cis face membrane" RELATED [] xref: GO:0033106 is_a: CCO:C0000021 ! Golgi membrane relationship: part_of CCO:C0000380 ! cis-Golgi network [Term] id: CCO:C0001527 name: CVT vesicle namespace: cellular_component def: "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p)." [GOC:rb, PMID:15138258] xref: GO:0033107 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0001528 name: CVT vesicle membrane namespace: cellular_component def: "The double lipid bilayer surrounding a CVT vesicle." [GOC:ecd] xref: GO:0033110 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0001527 ! CVT vesicle [Term] id: CCO:C0001529 name: attachment organelle membrane namespace: cellular_component def: "The lipid bilayer surrounding an attachment organelle." [GOC:ecd] xref: GO:0033111 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0001520 ! attachment organelle [Term] id: CCO:C0001530 name: cyanelle envelope namespace: cellular_component def: "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] xref: GO:0033112 is_a: CCO:C0000654 ! plastid envelope relationship: part_of CCO:C0000700 ! cyanelle [Term] id: CCO:C0001531 name: cyanelle membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope." [GOC:ecd] xref: GO:0033113 is_a: CCO:C0001634 ! plastid membrane relationship: part_of CCO:C0001530 ! cyanelle envelope [Term] id: CCO:C0001532 name: cyanelle thylakoid lumen namespace: cellular_component def: "The volume enclosed by a cyanelle thylakoid membrane." [GOC:mah] xref: GO:0033114 is_a: CCO:C0001370 ! plastid thylakoid lumen relationship: part_of CCO:C0000701 ! cyanelle thylakoid [Term] id: CCO:C0001533 name: cyanelle thylakoid membrane namespace: cellular_component def: "The lipid bilayer membrane of any thylakoid within a cyanelle." [GOC:mah] xref: GO:0033115 is_a: CCO:C0002020 ! plastid thylakoid membrane [Term] id: CCO:C0001534 name: ER-Golgi intermediate compartment membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the ER-Golgi intermediate compartment system." [GOC:mah, PMID:16723730] xref: GO:0033116 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0000374 ! ER-Golgi intermediate compartment [Term] id: CCO:C0001535 name: esterosome namespace: cellular_component def: "A vesicle filled with crystalline protein that shows sequence similarities with various esterases." [GOC:ecd, PMID:2307702] xref: GO:0033117 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0001536 name: esterosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes." [GOC:ecd, PMID:2307702] xref: GO:0033118 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0001535 ! esterosome [Term] id: CCO:C0001537 name: cytoskeletal calyx namespace: cellular_component def: "A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins." [PMID:12243744, PMID:9184090] xref: GO:0033150 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0001504 ! perinuclear theca [Term] id: CCO:C0001538 name: melanosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a melanosome." [GOC:mah] xref: GO:0033162 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane relationship: part_of CCO:C0001642 ! melanosome relationship: part_of CCO:C0001883 ! chitosome [Term] id: CCO:C0001539 name: microneme membrane namespace: cellular_component def: "The lipid bilayer surrounding a microneme." [GOC:mah] xref: GO:0033163 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0000911 ! microneme [Term] id: CCO:C0001540 name: interphotoreceptor matrix namespace: cellular_component def: "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance." [http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html, PMID:1862095, PMID:2194288] xref: GO:0033165 is_a: CCO:C0000203 ! proteinaceous extracellular matrix [Term] id: CCO:C0001541 name: hyaline layer namespace: cellular_component def: "A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms." [http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html, PMID:1721506, PMID:9473317] xref: GO:0033166 is_a: CCO:C0000203 ! proteinaceous extracellular matrix [Term] id: CCO:C0001542 name: ARC complex namespace: cellular_component def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA." [GOC:vw, PMID:17310250] synonym: "argonaute siRNA chaperone complex" EXACT [] xref: GO:0033167 is_a: CCO:C0001205 ! RNAi effector complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001543 name: gas vesicle shell namespace: cellular_component def: "The proteinaceous structure surrounding a gas vesicle." [GOC:ecd] synonym: "gas vesicle membrane" RELATED [] synonym: "gas vesicle wall" EXACT [] xref: GO:0033172 is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0001236 ! gas vesicle [Term] id: CCO:C0001544 name: chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the choroplast thylakoid membrane when the entire ATP synthase is assembled. The choroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits." [GOC:mah, GOC:pj, PMID:11032839] synonym: "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)" EXACT [] xref: GO:0033174 is_a: CCO:C0001922 ! proton-transporting ATP synthase complex, catalytic core F(1) relationship: part_of CCO:C0001947 ! chloroplast proton-transporting ATP synthase complex [Term] id: CCO:C0001545 name: chloroplast proton-transporting ATP synthase complex, coupling factor CF(o) namespace: cellular_component def: "All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins." [GOC:mah] synonym: "chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)" EXACT [] synonym: "chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)" EXACT [] xref: GO:0033175 is_a: CCO:C0001924 ! proton-transporting ATP synthase complex, coupling factor F(o) relationship: part_of CCO:C0001947 ! chloroplast proton-transporting ATP synthase complex [Term] id: CCO:C0001546 name: proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553] synonym: "hydrogen-translocating V-type ATPase complex" EXACT [] xref: GO:0033176 is_a: CCO:C0000792 ! proton-transporting two-sector ATPase complex [Term] id: CCO:C0001547 name: proton-transporting two-sector ATPase complex, proton-transporting domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056] xref: GO:0033177 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000792 ! proton-transporting two-sector ATPase complex [Term] id: CCO:C0001548 name: proton-transporting two-sector ATPase complex, catalytic domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056] xref: GO:0033178 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000792 ! proton-transporting two-sector ATPase complex [Term] id: CCO:C0001549 name: proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] xref: GO:0033179 is_a: CCO:C0001547 ! proton-transporting two-sector ATPase complex, proton-transporting domain relationship: part_of CCO:C0001546 ! proton-transporting V-type ATPase complex [Term] id: CCO:C0001550 name: proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553] xref: GO:0033180 is_a: CCO:C0001548 ! proton-transporting two-sector ATPase complex, catalytic domain relationship: part_of CCO:C0001546 ! proton-transporting V-type ATPase complex [Term] id: CCO:C0001551 name: plasma membrane proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase" EXACT [] xref: GO:0033181 is_a: CCO:C0001546 ! proton-transporting V-type ATPase complex [Term] id: CCO:C0001552 name: dolichol-phosphate-mannose synthase complex namespace: cellular_component def: "A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346] synonym: "dolichyl-phosphate beta-D-mannosyltransferase complex" EXACT [] synonym: "DPM synthase complex" EXACT [] xref: GO:0033185 is_a: CCO:C0001276 ! mannosyltransferase complex [Term] id: CCO:C0001553 name: CAF-1 complex namespace: cellular_component def: "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276] synonym: "chromatin assembly factor 1 complex" EXACT [] xref: GO:0033186 is_a: CCO:C0000281 ! chromatin assembly complex [Term] id: CCO:C0001554 name: Lsd1/2 complex namespace: cellular_component def: "A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast." [GOC:vw, PMID:17371846, PMID:17434129, PMID:17440621] synonym: "SAPHIRE complex" EXACT [PMID:17371846] synonym: "Swm complex" EXACT [PMID:17440621] synonym: "Swm1/2 complex" RELATED [PMID:17440621] xref: GO:0033193 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0001555 name: DNA helicase complex namespace: cellular_component def: "A protein complex that possesses DNA helicase activity." [GOC:mah] subset: goslim_pir xref: GO:0033202 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001556 name: DNA helicase A complex namespace: cellular_component def: "A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction." [PMID:9341218] xref: GO:0033203 is_a: CCO:C0001555 ! DNA helicase complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001557 name: vacuolar transporter chaperone complex namespace: cellular_component def: "A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p." [PMID:11823419, PMID:17079729] synonym: "VTC complex" EXACT [] xref: GO:0033254 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001558 name: SAS acetyltransferase complex namespace: cellular_component def: "A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p." [PMID:11731480, PMID:12626510, PMID:15788653] synonym: "SAS-I complex" EXACT [] xref: GO:0033255 is_a: CCO:C0001475 ! Piccolo NuA4 histone acetyltransferase complex [Term] id: CCO:C0001559 name: I-kappaB/NF-kappaB complex namespace: cellular_component def: "A protein complex containing an I-kappaB protein and one or more copies of an NF-kappaB protein; mediates regulation of NF-kappaB activity by I-kappaB." [GOC:mah, PMID:9407099] subset: goslim_pir xref: GO:0033256 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001560 name: Bcl3/NF-kappaB2 complex namespace: cellular_component def: "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] synonym: "Bcl3-NFKB2 complex" RELATED [] synonym: "Bcl3-p52 complex" EXACT [] xref: GO:0033257 is_a: CCO:C0001559 ! I-kappaB/NF-kappaB complex [Term] id: CCO:C0001561 name: CORVET complex namespace: cellular_component def: "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625] xref: GO:0033263 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001859 ! endosomal part [Term] id: CCO:C0001562 name: axon part namespace: cellular_component def: "A cell projection part that is part of an axon." [GOC:mh] xref: GO:0033267 is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0001004 ! axon [Term] id: CCO:C0001563 name: node of Ranvier namespace: cellular_component def: "An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed." [GOC:mh] xref: GO:0033268 is_a: CCO:C0001562 ! axon part [Term] id: CCO:C0001564 name: internode region of axon namespace: cellular_component def: "An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath." [GOC:mah, GOC:mh] xref: GO:0033269 is_a: CCO:C0001562 ! axon part [Term] id: CCO:C0001565 name: paranode region of axon namespace: cellular_component def: "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath." [GOC:mah, GOC:mh] xref: GO:0033270 is_a: CCO:C0001562 ! axon part [Term] id: CCO:C0001566 name: transcription factor TFTC complex namespace: cellular_component def: "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity." [PMID:10373431, PMID:9603525] xref: GO:0033276 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000811 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: CCO:C0001567 name: ribosomal subunit namespace: cellular_component def: "Either of the two ribonucleoprotein complexes that associate to form a ribosome." [GOC:mah] subset: gosubset_prok xref: GO:0033279 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000407 ! ribosome [Term] id: CCO:C0001568 name: TAT protein translocation system complex namespace: cellular_component def: "A complex of three proteins integral to the bacterial cytoplasmic membrane involved in translocation of folded proteins across the bacterial cytoplasmic membrane." [GOC:pamgo_curators] xref: GO:0033281 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001569 name: protein C inhibitor-acrosin complex namespace: cellular_component def: "A heterodimeric protein complex of protein C inhibitor and acrosin; complex formation inhibits the protease activity of acrosin." [PMID:11120760, PMID:7521127] synonym: "PCI-ACR complex" EXACT [] synonym: "PCI-acrosin complex" EXACT [] xref: GO:0033282 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000194 ! acrosomal membrane [Term] id: CCO:C0001570 name: intraconoid microtubule namespace: cellular_component def: "A microtubule located within the conoid." [GOC:mah, PMID:16518471] xref: GO:0033289 is_a: CCO:C0000434 ! microtubule relationship: part_of CCO:C0000909 ! apical complex [Term] id: CCO:C0001571 name: eukaryotic 48S preinitiation complex namespace: cellular_component def: "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049] synonym: "eukaryotic 48S initiation complex" RELATED [] synonym: "eukaryotic 48S pre-initiation complex" EXACT [] xref: GO:0016283 xref: GO:0033290 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001572 name: eukaryotic 80S initiation complex namespace: cellular_component def: "A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region." [GOC:hjd, PMID:15145049] xref: GO:0033291 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001573 name: SBF transcription complex namespace: cellular_component def: "A protein complex that acts as a transcription factor, composed of a regulatory subunit (Swi6) and a DNA-binding protein (Swi4), that activates gene expression during the G1/S transition of the cell cycle. Binds to a sequence motif called the SCB element (Swi4/6 cell cycle box, CACGAAA) which acts as a late Gl-specific UAS element in genes predominantly involved in budding, and in membrane and cell wall biosynthesis." [PMID:7917338] xref: GO:0033309 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0001574 name: chromatoid body namespace: cellular_component def: "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182)." [PMID:17183363] xref: GO:0033391 is_a: CCO:C0001019 ! ribonucleoprotein complex [Term] id: CCO:C0001575 name: HULC complex namespace: cellular_component def: "A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2." [GOC:mah, PMID:17363370, PMID:17374714] xref: GO:0033503 is_a: CCO:C0000026 ! ubiquitin ligase complex is_a: CCO:C0001219 ! ubiquitin conjugating enzyme complex relationship: part_of CCO:C0000119 ! heterochromatin [Term] id: CCO:C0001576 name: monopolin complex namespace: cellular_component def: "A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits." [GOC:mah, GOC:rb, PMID:17627824] synonym: "monopolin subcomplex Csm1/Lrs4" NARROW [] synonym: "Pcs1/Mde4 complex" NARROW [] xref: GO:0033551 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000104 ! condensed chromosome kinetochore [Term] id: CCO:C0001577 name: rDNA heterochromatin namespace: cellular_component def: "A region of heterochromatin located at the rDNA repeats in a chromosome." [GOC:mah] synonym: "ribosomal DNA heterochromatin" EXACT [] xref: GO:0033553 is_a: CCO:C0000119 ! heterochromatin [Term] id: CCO:C0001578 name: Slx1-Slx4 complex namespace: cellular_component def: "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377] xref: GO:0033557 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001873 ! nuclear chromosome part [Term] id: CCO:C0001579 name: ESCRT-0 complex namespace: cellular_component def: "A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals." [GOC:rb, PMID:12055639, PMID:17543868] synonym: "Hrs/STAM complex" EXACT [] synonym: "Vps27p-Hse1p complex" EXACT [] xref: GO:0033565 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001859 ! endosomal part [Term] id: CCO:C0001580 name: high affinity iron permease complex namespace: cellular_component def: "A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell." [GOC:jp, PMID:16522632, PMID:8599111] xref: GO:0033573 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001581 name: rhabdomere membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the rhabdomere." [GOC:mah] xref: GO:0033583 is_a: CCO:C0001173 ! cell projection membrane relationship: part_of CCO:C0000771 ! rhabdomere [Term] id: CCO:C0001582 name: Elongator holoenzyme complex namespace: cellular_component def: "A heterohexameric protein complex that is involved in tRNA modification, and exerts indirect effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes." [GOC:mah, PMID:11689709, PMID:17018299] synonym: "Elongator core complex" RELATED [] xref: GO:0033588 xref: GO:0033589 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001583 name: BRCA2-MAGE-D1 complex namespace: cellular_component def: "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293] xref: GO:0033593 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: location_of CCO:B0010859 ! BRCA2_HUMAN-Phosphoserine683 [Term] id: CCO:C0001584 name: TSC1-TSC2 complex namespace: cellular_component def: "A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671] synonym: "tuberin-hamartin complex " EXACT [] synonym: "tuberous sclerosis complex" EXACT [] xref: GO:0033596 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part relationship: location_of CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 [Term] id: CCO:C0001585 name: mitotic checkpoint complex namespace: cellular_component def: "A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20." [PMID:10704439, PMID:11535616, PMID:11726501, PMID:17650307] synonym: "MCC" EXACT [] xref: GO:0033597 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001586 name: SOD1-Bcl-2 complex namespace: cellular_component def: "A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway." [PMID:15233914, PMID:16790527] xref: GO:0033607 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001587 name: Mei2 nuclear dot namespace: cellular_component def: "A nuclear body that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I." [PMID:12808043] synonym: "Mei2 dot" EXACT [] xref: GO:0033620 is_a: CCO:C0000817 ! nuclear body [Term] id: CCO:C0001588 name: host cell part namespace: cellular_component def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] xref: GO:0033643 is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0001804 ! host cell [Term] id: CCO:C0001589 name: host cell membrane namespace: cellular_component def: "Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] xref: GO:0033644 is_a: CCO:C0001588 ! host cell part [Term] id: CCO:C0001590 name: host cell endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] xref: GO:0033645 is_a: CCO:C0001589 ! host cell membrane [Term] id: CCO:C0001591 name: host intracellular part namespace: cellular_component def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] xref: GO:0033646 is_a: CCO:C0001803 ! intracellular region of host [Term] id: CCO:C0001592 name: host intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] xref: GO:0033647 is_a: CCO:C0001591 ! host intracellular part [Term] id: CCO:C0001594 name: host cell mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "host mitochondria" EXACT [] xref: GO:0033650 is_a: CCO:C0001599 ! host cell cytoplasm part is_a: CCO:C0002126 ! host intracellular membrane-bounded organelle [Term] id: CCO:C0001595 name: host cell plastid namespace: cellular_component def: "Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] xref: GO:0033651 is_a: CCO:C0001599 ! host cell cytoplasm part is_a: CCO:C0002126 ! host intracellular membrane-bounded organelle [Term] id: CCO:C0001596 name: host cell chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] xref: GO:0033652 is_a: CCO:C0001595 ! host cell plastid [Term] id: CCO:C0001597 name: host cell chloroplast part namespace: cellular_component def: "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "host chloroplast component" EXACT [] xref: GO:0033653 is_a: CCO:C0001596 ! host cell chloroplast [Term] id: CCO:C0001598 name: host cell chloroplast thylakoid membrane namespace: cellular_component def: "Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] xref: GO:0033654 is_a: CCO:C0001597 ! host cell chloroplast part [Term] id: CCO:C0001599 name: host cell cytoplasm part namespace: cellular_component def: "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "cytoplasm component" BROAD [] xref: GO:0033655 is_a: CCO:C0001591 ! host intracellular part relationship: part_of CCO:C0001009 ! host cell cytoplasm [Term] id: CCO:C0001600 name: pericanalicular vesicle namespace: cellular_component def: "A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes." [PMID:15763347, PMID:9790571] xref: GO:0033675 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0001601 name: Clr6 histone deacetylase complex I/I' namespace: cellular_component def: "A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe)." [GOC:vw, PMID:17450151] xref: GO:0033698 is_a: CCO:C0000008 ! histone deacetylase complex [Term] id: CCO:C0001602 name: SUMO-targeted ubiquitin ligase complex namespace: cellular_component def: "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865] xref: GO:0033768 is_a: CCO:C0000027 ! nuclear ubiquitin ligase complex [Term] id: CCO:C0001603 name: basal labyrinth namespace: cellular_component def: "A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane." [GOC:mah, GOC:sart, PMID:11640882] xref: GO:0033774 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0001897 ! basal part of cell [Term] id: CCO:C0001604 name: subapical complex namespace: cellular_component def: "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938] synonym: "SAC" BROAD [] xref: GO:0035003 is_a: CCO:C0000463 ! intercellular junction relationship: part_of CCO:C0001769 ! apical junction complex [Term] id: CCO:C0001605 name: polytene chromosome, telomeric region namespace: cellular_component def: "The terminal region of a polytene chromosome." [GOC:bf] xref: GO:0035012 is_a: CCO:C0000108 ! chromosome, telomeric region relationship: part_of CCO:C0000298 ! polytene chromosome [Term] id: CCO:C0001608 name: phosphoinositide 3-kinase complex, class III namespace: cellular_component def: "A complex containing a heterodimer of a catalytic Class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069] synonym: "class III PI3K complex" EXACT [] xref: GO:0035032 is_a: CCO:C0000492 ! phosphoinositide 3-kinase complex [Term] id: CCO:C0001609 name: RCAF complex namespace: cellular_component def: "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4." [GOC:bf, PMID:10591219] synonym: "replication-coupling assembly factor complex" EXACT [] xref: GO:0035059 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0001610 name: brahma complex namespace: cellular_component def: "A multi-subunit ATP-dependent chromatin remodeling complex, a counterpart of the SWI/SNF complex that contains the ATPase product of the Drosophila brahma gene." [GOC:bf, PMID:10809665, PMID:12482982] synonym: "BRM complex" EXACT [] xref: GO:0035060 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0001611 name: interchromatin granule namespace: cellular_component def: "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] synonym: "ICG" EXACT [] xref: GO:0035061 is_a: CCO:C0000817 ! nuclear body [Term] id: CCO:C0001612 name: omega speckle namespace: cellular_component def: "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] xref: GO:0035062 is_a: CCO:C0000820 ! nuclear speck [Term] id: CCO:C0001613 name: micro-ribonucleoprotein complex namespace: cellular_component def: "A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA." [GOC:bf, PMID:14559182] synonym: "miRNP complex" EXACT [] xref: GO:0035068 is_a: CCO:C0001019 ! ribonucleoprotein complex [Term] id: CCO:C0001614 name: cilium axoneme namespace: cellular_component def: "The bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684] xref: GO:0035085 is_a: CCO:C0000482 ! axoneme is_a: CCO:C0001860 ! cilium part [Term] id: CCO:C0001615 name: flagellar axoneme namespace: cellular_component def: "The bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684] synonym: "flagellum axoneme" EXACT [] xref: GO:0035086 is_a: CCO:C0000482 ! axoneme is_a: CCO:C0001861 ! microtubule-based flagellum part [Term] id: CCO:C0001616 name: histone methyltransferase complex namespace: cellular_component def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf] subset: goslim_pir xref: GO:0035097 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part relationship: location_of CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:C0001617 name: ESC/E(Z) complex namespace: cellular_component def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12." [GOC:bf, PMID:12408863, PMID:12408864] synonym: "Extra Sex Combs/Enhancer of Zeste complex" EXACT [] xref: GO:0035098 is_a: CCO:C0001285 ! PcG protein complex is_a: CCO:C0001616 ! histone methyltransferase complex [Term] id: CCO:C0001618 name: FACT complex namespace: cellular_component def: "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108] synonym: "Facilitates chromatin transcription complex" EXACT [] xref: GO:0035101 is_a: CCO:C0000523 ! transcription elongation factor complex [Term] id: CCO:C0001619 name: PRC1 complex namespace: cellular_component def: "An insect multiprotein complex containing the products of many of the Polycomb Group genes including Polycomb, Posterior sex combs, polyhomeotic and Sex comb on midleg. The Polycomb Group proteins are required for stable long-term maintenance of transcriptionally repressed states and the PRC1 complex directly antagonizes ATP-dependent remodeling of nucleosomal arrays." [GOC:bf, PMID:10412979] synonym: "Polycomb repressive complex 1" EXACT [] xref: GO:0035102 is_a: CCO:C0001285 ! PcG protein complex [Term] id: CCO:C0001620 name: exon-exon junction complex namespace: cellular_component def: "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] synonym: "EJC" EXACT [] xref: GO:0035145 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001621 name: germline ring canal outer rim namespace: cellular_component def: "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues." [PMID:12435357, PMID:7925006] comment: See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'. xref: GO:0035182 is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0001895 ! germline ring canal [Term] id: CCO:C0001622 name: germline ring canal inner rim namespace: cellular_component def: "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858] comment: See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'. xref: GO:0035183 is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0001895 ! germline ring canal [Term] id: CCO:C0001623 name: Rb-E2F complex namespace: cellular_component def: "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] synonym: "retinoblastoma-E2F complex" EXACT [] xref: GO:0035189 is_a: CCO:C0000272 ! transcription factor complex [Term] id: CCO:C0001624 name: cytoneme namespace: cellular_component def: "A long, thin and polarized actin-based extension that projects from a cell and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901] subset: goslim_pir xref: GO:0035230 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0001625 name: ciliary rootlet namespace: cellular_component def: "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [PMID:12427867] xref: GO:0035253 is_a: CCO:C0001849 ! cytoskeletal part is_a: CCO:C0001860 ! cilium part [Term] id: CCO:C0001626 name: NuA4 histone acetyltransferase complex namespace: cellular_component def: "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] synonym: "TIP60 histone acetylase complex" EXACT [] synonym: "TIP60 histone acetyltransferase complex" EXACT [] xref: GO:0035267 is_a: CCO:C0001724 ! H4/H2A histone acetyltransferase complex [Term] id: CCO:C0001627 name: Hedgehog signaling complex namespace: cellular_component def: "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936] synonym: "Hedgehog signalling complex" EXACT [] synonym: "HSC" EXACT [] xref: GO:0035301 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001628 name: interleukin-12 receptor complex namespace: cellular_component def: "Complex that binds interleukin-12; comprises an alpha and a beta subunit." [GOC:mah, PMID:10971505] xref: GO:0042022 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001629 name: host cell nucleus namespace: cellular_component def: "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok xref: GO:0033649 xref: GO:0042025 is_a: CCO:C0002126 ! host intracellular membrane-bounded organelle relationship: part_of CCO:C0001803 ! intracellular region of host [Term] id: CCO:C0001630 name: T cell receptor complex namespace: cellular_component def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte receptor complex" EXACT [] synonym: "T-cell receptor complex" EXACT [] synonym: "T-lymphocyte receptor complex" EXACT [] synonym: "TCR" EXACT [] xref: GO:0042101 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: location_of CCO:B0001458 ! BCL10_HUMAN relationship: part_of CCO:C0000186 ! immunological synapse [Term] id: CCO:C0001631 name: alpha-beta T cell receptor complex namespace: cellular_component def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta T lymphocyte receptor complex" EXACT [] synonym: "alpha-beta T-cell receptor complex" EXACT [] synonym: "alpha-beta T-lymphocyte receptor complex" EXACT [] synonym: "alpha-beta TCR complex" EXACT [] xref: GO:0042105 is_a: CCO:C0001630 ! T cell receptor complex [Term] id: CCO:C0001632 name: gamma-delta T cell receptor complex namespace: cellular_component def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"] synonym: "gamma-delta T lymphocyte receptor complex" EXACT [] synonym: "gamma-delta T-cell receptor complex" EXACT [] synonym: "gamma-delta T-lymphocyte receptor complex" EXACT [] synonym: "gamma-delta TCR complex" EXACT [] xref: GO:0042106 is_a: CCO:C0001630 ! T cell receptor complex [Term] id: CCO:C0001633 name: nematocyst namespace: cellular_component def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [GOC:jl, UniProtKB:P01533] synonym: "cnidocyst" EXACT [] xref: GO:0042151 is_a: CCO:C0001867 ! cell cortex part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle [Term] id: CCO:C0001634 name: plastid membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah] xref: GO:0042170 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000654 ! plastid envelope [Term] id: CCO:C0001635 name: nuclear envelope-endoplasmic reticulum network namespace: cellular_component def: "The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum." [GOC:jl] synonym: "NE-ER continuum" EXACT [] synonym: "NE-ER network" EXACT [] synonym: "nuclear envelope-endoplasmic reticulum continuum" EXACT [] synonym: "nuclear envelope-ER network" EXACT [] xref: GO:0042175 is_a: CCO:C0000766 ! membrane is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0000733 ! endomembrane system [Term] id: CCO:C0001636 name: nuclear RNA export factor complex namespace: cellular_component def: "A complex of NXF1 and NXF2 required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [UniProtKB:Q9U1H9] synonym: "Mex67-Mtr2 complex" EXACT [] synonym: "NXF1-NXT1 complex" EXACT [] synonym: "TAP-p15 complex" EXACT [] xref: GO:0042272 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0001637 name: paraspeckles namespace: cellular_component def: "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] xref: GO:0042382 is_a: CCO:C0000817 ! nuclear body [Term] id: CCO:C0001638 name: sarcolemma namespace: cellular_component def: "The outer membrane of a muscle fiber, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0042383 is_a: CCO:C0000444 ! plasma membrane [Term] id: CCO:C0001639 name: myosin III complex namespace: cellular_component def: "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0042385 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001640 name: nuclear inclusion body namespace: cellular_component def: "Intranuclear foci at which aggregated proteins have been sequestered." [GOC:jl] xref: GO:0042405 is_a: CCO:C0000775 ! inclusion body is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001641 name: extrinsic to endoplasmic reticulum membrane namespace: cellular_component def: "Loosely bound to one surface of the endoplasmic reticulum membrane, but not integrated into the hydrophobic region." [GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "extrinsic to ER membrane" EXACT [] xref: GO:0042406 is_a: CCO:C0001199 ! extrinsic to organelle membrane is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0001642 name: melanosome namespace: cellular_component def: "A tissue-specific, membrane bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] xref: GO:0042470 is_a: CCO:C0002006 ! pigment granule [Term] id: CCO:C0001643 name: MCM complex namespace: cellular_component def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] synonym: "mini-chromosome maintenance complex" EXACT [] xref: GO:0042555 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0001793 ! nuclear replication fork [Term] id: CCO:C0001644 name: importin alpha-subunit nuclear export complex namespace: cellular_component def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134] xref: GO:0042563 is_a: CCO:C0001119 ! nucleocytoplasmic shuttling complex [Term] id: CCO:C0001645 name: NLS-dependent protein nuclear import complex namespace: cellular_component def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134] xref: GO:0042564 is_a: CCO:C0001119 ! nucleocytoplasmic shuttling complex [Term] id: CCO:C0001646 name: RNA nuclear export complex namespace: cellular_component def: "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123] xref: GO:0042565 is_a: CCO:C0001119 ! nucleocytoplasmic shuttling complex [Term] id: CCO:C0001647 name: hydrogenosome namespace: cellular_component def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569] subset: goslim_pir xref: GO:0042566 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0001648 name: insulin-like growth factor ternary complex namespace: cellular_component def: "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] synonym: "IGF ternary complex" EXACT [] xref: GO:0042567 is_a: CCO:C0000829 ! insulin-like growth factor binding protein complex [Term] id: CCO:C0001649 name: insulin-like growth factor binary complex namespace: cellular_component def: "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] synonym: "IGF binary complex" EXACT [] xref: GO:0042568 is_a: CCO:C0000829 ! insulin-like growth factor binding protein complex [Term] id: CCO:C0001650 name: immunoglobulin complex, circulating namespace: cellular_component def: "A multi-subunit complex that functions as an antibody and circulates in the blood, lymph, mucosal areas, and other fluids of the body. In its basic form, circulating immunoglobulin is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [ISBN:0781735149 "Fundamental Immunology"] xref: GO:0042571 is_a: CCO:C0000888 ! immunoglobulin complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0001651 name: DNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:12045093] subset: goslim_pir subset: gosubset_prok xref: GO:0042575 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001652 name: microbody namespace: cellular_component def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir xref: GO:0042579 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0001653 name: mannosome namespace: cellular_component def: "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531] xref: GO:0042580 is_a: CCO:C0000359 ! peroxisome [Term] id: CCO:C0001654 name: specific granule namespace: cellular_component def: "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:7334549] synonym: "secondary granule" EXACT [] xref: GO:0042581 is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001655 name: azurophil granule namespace: cellular_component def: "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "primary granule" EXACT [] xref: GO:0042582 is_a: CCO:C0000349 ! primary lysosome is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001656 name: chromaffin granule namespace: cellular_component def: "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0042583 is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001657 name: chromaffin granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0042584 is_a: CCO:C0001031 ! secretory granule membrane relationship: part_of CCO:C0001656 ! chromaffin granule [Term] id: CCO:C0001658 name: germinal vesicle namespace: cellular_component def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/] synonym: "primary oocyte nucleus" EXACT [] xref: GO:0042585 is_a: CCO:C0000179 ! female germ cell nucleus [Term] id: CCO:C0001659 name: glycogen granule namespace: cellular_component def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, http://148.216.10.83/cellbio/the_mi19.gif, PMID:12179957] synonym: "glycogen particle" EXACT [] xref: GO:0042587 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001660 name: zymogen granule namespace: cellular_component def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0042588 is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001661 name: zymogen granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl] xref: GO:0042589 is_a: CCO:C0001031 ! secretory granule membrane relationship: part_of CCO:C0001660 ! zymogen granule [Term] id: CCO:C0001662 name: periplasmic space namespace: cellular_component def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi)." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "periplasm" EXACT [] xref: GO:0005620 xref: GO:0042597 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001663 name: vesicular fraction namespace: cellular_component def: "Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: gosubset_prok xref: GO:0042598 is_a: CCO:C0000244 ! membrane fraction [Term] id: CCO:C0001664 name: lamellar body namespace: cellular_component def: "A membrane bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:jl, PMID:12243725] synonym: "keratinosome" EXACT [] synonym: "lamellar granule" EXACT [] synonym: "membrane-coating granule" EXACT [] synonym: "Odland body" EXACT [] xref: GO:0042599 is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001665 name: chorion namespace: cellular_component def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO. subset: goslim_pir xref: GO:0042600 is_a: CCO:C0000999 ! external encapsulating structure [Term] id: CCO:C0001666 name: endospore-forming forespore namespace: cellular_component def: "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions." [GOC:jl, GOC:mtg_sensu, ISBN:0697286029] subset: gosubset_prok synonym: "forespore (sensu Bacteria)" EXACT [] xref: GO:0042601 is_a: CCO:C0002134 ! intracellular immature spore [Term] id: CCO:C0001667 name: capsule namespace: cellular_component def: "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and can not be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication." [GOC:mlg] subset: gosubset_prok synonym: "capsule (sensu Bacteria)" EXACT [] synonym: "capsule (sensu Fungi)" EXACT [] xref: GO:0030113 xref: GO:0042603 xref: GO:0042604 is_a: CCO:C0000959 ! glycocalyx [Term] id: CCO:C0001668 name: MHC protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149 "Fundamental Immunology", PMID:15928678, PMID:16153240] subset: goslim_pir xref: GO:0042611 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001669 name: MHC class I protein complex namespace: cellular_component def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149 "Fundamental Immunology"] comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'. xref: GO:0042612 is_a: CCO:C0001668 ! MHC protein complex [Term] id: CCO:C0001670 name: MHC class II protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678] xref: GO:0042613 is_a: CCO:C0001668 ! MHC protein complex [Term] id: CCO:C0001671 name: photoreceptor outer segment membrane namespace: cellular_component def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." [GOC:jl] xref: GO:0042622 is_a: CCO:C0000766 ! membrane is_a: CCO:C0001860 ! cilium part relationship: part_of CCO:C0000185 ! photoreceptor outer segment [Term] id: CCO:C0001672 name: chylomicron namespace: cellular_component def: "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, GOC:rl, http://biotech.icmb.utexas.edu/search/dict-search.html, http://cancerweb.ncl.ac.uk/] xref: GO:0042627 is_a: CCO:C0002138 ! plasma lipoprotein particle [Term] id: CCO:C0001673 name: mast cell granule namespace: cellular_component def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215] xref: GO:0042629 is_a: CCO:C0000347 ! lysosome [Term] id: CCO:C0001674 name: actomyosin namespace: cellular_component def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] xref: GO:0042641 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000753 ! actin cytoskeleton [Term] id: CCO:C0001675 name: actomyosin, myosin complex part namespace: cellular_component def: "The myosin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] xref: GO:0042642 is_a: CCO:C0000788 ! myosin complex relationship: part_of CCO:C0001674 ! actomyosin [Term] id: CCO:C0001676 name: actomyosin, actin part namespace: cellular_component def: "The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] xref: GO:0042643 is_a: CCO:C0000442 ! actin filament relationship: part_of CCO:C0001674 ! actomyosin [Term] id: CCO:C0001677 name: chloroplast nucleoid namespace: cellular_component def: "The region of a chloroplast to which the DNA is confined." [GOC:jl] xref: GO:0042644 is_a: CCO:C0001679 ! plastid nucleoid is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000681 ! chloroplast stroma [Term] id: CCO:C0001678 name: mitochondrial nucleoid namespace: cellular_component def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl] xref: GO:0042645 is_a: CCO:C0000563 ! nucleoid is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0001679 name: plastid nucleoid namespace: cellular_component def: "The region of a plastid to which the DNA is confined." [GOC:jl] xref: GO:0042646 is_a: CCO:C0000563 ! nucleoid is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000660 ! plastid stroma [Term] id: CCO:C0001680 name: proplastid nucleoid namespace: cellular_component def: "The region of a proplastid to which the DNA is confined." [GOC:jl] xref: GO:0042647 is_a: CCO:C0001679 ! plastid nucleoid relationship: part_of CCO:C0000682 ! proplastid stroma [Term] id: CCO:C0001681 name: chloroplast chromosome namespace: cellular_component def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl] xref: GO:0042648 is_a: CCO:C0000637 ! plastid chromosome is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0001677 ! chloroplast nucleoid [Term] id: CCO:C0001682 name: prothylakoid namespace: cellular_component def: "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175] xref: GO:0042649 is_a: CCO:C0000689 ! thylakoid is_a: CCO:C0001854 ! plastid part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle relationship: part_of CCO:C0000642 ! etioplast [Term] id: CCO:C0001683 name: prothylakoid membrane namespace: cellular_component def: "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175] xref: GO:0042650 is_a: CCO:C0001684 ! thylakoid membrane is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0001682 ! prothylakoid [Term] id: CCO:C0001684 name: thylakoid membrane namespace: cellular_component def: "The pigmented membrane of any thylakoid." [GOC:jl] subset: gosubset_prok xref: GO:0042651 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001855 ! thylakoid part [Term] id: CCO:C0001685 name: mitochondrial respiratory chain complex I, peripheral segment namespace: cellular_component def: "The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jic, GOC:mtg_sensu, ISBN:0716749556] synonym: "NADH dehydrogenase (ubiquinone) complex, peripheral segment (sensu Eukaryota)" EXACT [] synonym: "NADH-Q oxidoreductase complex, peripheral segment (sensu Eukaryota)" EXACT [] synonym: "respiratory chain complex I, peripheral segment (sensu Eukaryota)" EXACT [] xref: GO:0042652 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000333 ! mitochondrial respiratory chain complex I [Term] id: CCO:C0001686 name: mitochondrial respiratory chain complex I, membrane segment namespace: cellular_component def: "The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jic, GOC:mtg_sensu, ISBN:0716749556] synonym: "NADH-Q oxidoreductase complex, membrane segment (sensu Eukaryota)" EXACT [] synonym: "respiratory chain complex I, membrane segment (sensu Eukaryota)" EXACT [] xref: GO:0042653 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000333 ! mitochondrial respiratory chain complex I [Term] id: CCO:C0001687 name: succinate-CoA ligase complex namespace: cellular_component def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [EC:6.2.1.4, EC:6.2.1.5, GOC:jl] subset: gosubset_prok xref: GO:0042709 is_a: CCO:C0001903 ! tricarboxylic acid cycle enzyme complex [Term] id: CCO:C0001688 name: chromatophore namespace: cellular_component def: "A pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria which is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle." [GOC:jl, ISBN:0395825172, PMID:11867431] comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin. subset: gosubset_prok synonym: "chromatophore vesicle" EXACT [] synonym: "thylakoid (sensu Bacteria)" RELATED [] synonym: "thylakoid (sensu Proteobacteria)" RELATED [] xref: GO:0042716 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0001689 name: chromatophore membrane namespace: cellular_component def: "The lipid bilayer surrounding a chromatophore, a pigment-bearing vesicle found in certain photosynthetic bacteria and cyanobacteria." [GOC:jl, ISBN:0395825172, PMID:11867431] subset: gosubset_prok xref: GO:0042717 is_a: CCO:C0001024 ! cytoplasmic vesicle membrane is_a: CCO:C0001688 ! chromatophore [Term] id: CCO:C0001690 name: yolk granule namespace: cellular_component def: "Discrete structures that partition the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, http://148.216.10.83/cellbio/eggs.htm] xref: GO:0042718 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001691 name: mitochondrial intermembrane space protein transporter complex namespace: cellular_component def: "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629] synonym: "Tim9-Tim10 complex" NARROW [] xref: GO:0042719 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000341 ! mitochondrial intermembrane space [Term] id: CCO:C0001692 name: mitochondrial inner membrane peptidase complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769] synonym: "IMP" NARROW [] xref: GO:0042720 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0001693 name: mitochondrial inner membrane protein insertion complex namespace: cellular_component def: "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane." [PMID:12191765] synonym: "Tim22 complex" NARROW [] xref: GO:0042721 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001874 ! mitochondrial membrane part relationship: part_of CCO:C0000329 ! mitochondrial inner membrane [Term] id: CCO:C0001694 name: DASH complex namespace: cellular_component def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability." [GOC:jl, PMID:11782438, PMID:11799062] comment: Note that this complex is conserved in fungi but has not been observed in metazoans. synonym: "Dam1 complex" EXACT [] synonym: "DDD complex" EXACT [] synonym: "Duo1p-Dam1p-Dad1p complex" EXACT [] xref: GO:0042729 is_a: CCO:C0000435 ! microtubule associated complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0000105 ! condensed nuclear chromosome kinetochore relationship: part_of CCO:C0000396 ! kinetochore microtubule [Term] id: CCO:C0001695 name: presynaptic membrane namespace: cellular_component def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0042734 is_a: CCO:C0000766 ! membrane is_a: CCO:C0001875 ! synapse part [Term] id: CCO:C0001696 name: protein body namespace: cellular_component def: "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047] xref: GO:0042735 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0001697 name: giant axon namespace: cellular_component def: "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0042757 is_a: CCO:C0001004 ! axon [Term] id: CCO:C0001700 name: GPI-anchor transamidase complex namespace: cellular_component def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054] comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity. synonym: "GPIT complex" EXACT [] xref: GO:0042765 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0000990 ! integral to endoplasmic reticulum membrane [Term] id: CCO:C0001701 name: polysomal ribosome namespace: cellular_component def: "A ribosome bound to mRNA that forms part of a polysome." [GOC:jl] synonym: "active ribosome" BROAD [] xref: GO:0042788 is_a: CCO:C0000407 ! ribosome relationship: part_of CCO:C0000410 ! polysome [Term] id: CCO:C0001702 name: central vacuole namespace: cellular_component def: "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [http://www.wikipedia.org/] xref: GO:0042807 is_a: CCO:C0002152 ! plant-type vacuole [Term] id: CCO:C0001703 name: MHC class I peptide loading complex namespace: cellular_component def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934] comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi. subset: goslim_pir xref: GO:0042824 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001851 ! endoplasmic reticulum part [Term] id: CCO:C0001704 name: TAP complex namespace: cellular_component def: "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934] synonym: "transporter associated with antigen presentation" EXACT [] xref: GO:0042825 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0001703 ! MHC class I peptide loading complex [Term] id: CCO:C0001705 name: platelet dense granule namespace: cellular_component def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682, PMID:11487378] synonym: "bull's eye body" EXACT [] synonym: "platelet dense body" EXACT [] xref: GO:0042827 is_a: CCO:C0000985 ! secretory granule [Term] id: CCO:C0001706 name: cell projection namespace: cellular_component def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_pir subset: gosubset_prok xref: GO:0042995 is_a: CCO:C0001882 ! cell part relationship: location_of CCO:B0002099 ! CP250_HUMAN relationship: location_of CCO:B0010926 ! CASL_HUMAN-Phosphotyrosine166 relationship: location_of CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 [Term] id: CCO:C0001707 name: neuron projection namespace: cellular_component def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_pir synonym: "neurite" NARROW [] synonym: "neuronal cell projection" EXACT [] xref: GO:0043005 is_a: CCO:C0001706 ! cell projection [Term] id: CCO:C0001708 name: NADPH oxidase complex namespace: cellular_component def: "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767] synonym: "flavocytochrome b558" NARROW [] synonym: "respiratory-burst oxidase" RELATED [] xref: GO:0043020 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001709 name: cell soma namespace: cellular_component def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. subset: goslim_pir synonym: "cell body" EXACT [] xref: GO:0043025 is_a: CCO:C0001882 ! cell part relationship: location_of CCO:B0001802 ! CD5R1_HUMAN relationship: location_of CCO:B0011115 ! CDK5_HUMAN-Phosphoserine159 [Term] id: CCO:C0001710 name: isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591] subset: goslim_pir subset: gosubset_prok synonym: "debranching enzyme complex" BROAD [] xref: GO:0043033 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0001711 name: costamere namespace: cellular_component def: "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:6405378] xref: GO:0043034 is_a: CCO:C0001868 ! contractile fiber part relationship: part_of CCO:C0000932 ! myofibril [Term] id: CCO:C0001712 name: starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] synonym: "starch granule" EXACT [] xref: GO:0043036 is_a: CCO:C0001854 ! plastid part [Term] id: CCO:C0001713 name: germ cell nucleus namespace: cellular_component def: "The nucleus of a germ cell, a cell specialized to produce haploid gametes, and its descendents." [GOC:go_curators, http://cancerweb.ncl.ac.uk] synonym: "germ-cell nucleus" EXACT [] xref: GO:0043073 is_a: CCO:C0000252 ! nucleus [Term] id: CCO:C0001714 name: megasporocyte nucleus namespace: cellular_component def: "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153] synonym: "megaspore mother cell nucleus" EXACT [] xref: GO:0043076 is_a: CCO:C0000252 ! nucleus [Term] id: CCO:C0001715 name: polar nucleus namespace: cellular_component def: "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153] xref: GO:0043078 is_a: CCO:C0001714 ! megasporocyte nucleus [Term] id: CCO:C0001716 name: antipodal cell nucleus namespace: cellular_component def: "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [GOC:jl, http://cancerweb.ncl.ac.uk] xref: GO:0043079 is_a: CCO:C0001714 ! megasporocyte nucleus [Term] id: CCO:C0001717 name: megagametophyte egg cell nucleus namespace: cellular_component def: "The nucleus of a plant egg cell, the female gamete, at the micropylar end of the embryo and its descendents." [GOC:jl, GOC:mtg_sensu] synonym: "egg cell nucleus (sensu Viridiplantae)" EXACT [] xref: GO:0043082 is_a: CCO:C0001714 ! megasporocyte nucleus [Term] id: CCO:C0001718 name: synaptic cleft namespace: cellular_component def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm] xref: GO:0043083 is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001875 ! synapse part [Term] id: CCO:C0001719 name: acrosomal matrix namespace: cellular_component def: "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729] xref: GO:0043159 is_a: CCO:C0001856 ! vacuolar part relationship: part_of CCO:C0000177 ! acrosome [Term] id: CCO:C0001720 name: acrosomal lumen namespace: cellular_component def: "The volume enclosed within the acrosome membrane." [GOC:go_curators] xref: GO:0043160 is_a: CCO:C0001731 ! lysosomal lumen relationship: part_of CCO:C0000177 ! acrosome [Term] id: CCO:C0001721 name: P granule namespace: cellular_component def: "A small protein and RNA containing electron dense organelle, not surrounded by a membrane, that is associated with germ nuclei in the gonad and localized to germ cells and their precursors throughout development." [GOC:kva, PMID:11262230] xref: GO:0043186 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle relationship: part_of CCO:C0001952 ! pole plasm [Term] id: CCO:C0001722 name: cell septum surface namespace: cellular_component def: "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators] synonym: "septum surface" BROAD [] xref: GO:0043187 is_a: CCO:C0001876 ! cell septum part [Term] id: CCO:C0001723 name: cell septum edging namespace: cellular_component def: "The cell wall material that surrounds the septum in fungal cells." [GOC:vw] synonym: "septum edging" BROAD [] synonym: "septum edging (sensu Fungi)" EXACT [] xref: GO:0043188 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0002066 ! fungal-type cell wall [Term] id: CCO:C0001724 name: H4/H2A histone acetyltransferase complex namespace: cellular_component def: "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah] synonym: "H4/H2A HAT complex" EXACT [] xref: GO:0043189 is_a: CCO:C0000011 ! histone acetyltransferase complex [Term] id: CCO:C0001725 name: ATP-binding cassette (ABC) transporter complex namespace: cellular_component def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107] subset: goslim_pir subset: gosubset_prok synonym: "ABC-type efflux permease activity" NARROW [] synonym: "ABC-type efflux porter activity" NARROW [] synonym: "ABC-type uptake permease activity" NARROW [] synonym: "ATP-binding cassette (ABC) transporter activity" RELATED [] synonym: "ATP-binding cassette (ABC) transporter complex (sensu Bacteria and Archaea)" EXACT [] synonym: "ATP-binding cassette (ABC) transporter complex (sensu Eukaryota)" EXACT [] synonym: "mating pheromone exporter" NARROW [] xref: GO:0043190 xref: GO:0043191 xref: GO:0043192 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part [Term] id: CCO:C0001726 name: initial segment namespace: cellular_component def: "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln] xref: GO:0043194 is_a: CCO:C0001562 ! axon part [Term] id: CCO:C0001727 name: terminal button namespace: cellular_component def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln] synonym: "bouton" EXACT [] synonym: "presynaptic bouton" EXACT [] synonym: "synaptic bouton" EXACT [] xref: GO:0043195 is_a: CCO:C0001562 ! axon part [Term] id: CCO:C0001728 name: varicosity namespace: cellular_component def: "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln] xref: GO:0043196 is_a: CCO:C0001562 ! axon part [Term] id: CCO:C0001729 name: dendritic spine namespace: cellular_component def: "Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln] xref: GO:0043197 is_a: CCO:C0001881 ! cell projection part relationship: location_of CCO:B0001802 ! CD5R1_HUMAN relationship: part_of CCO:C0001005 ! dendrite [Term] id: CCO:C0001730 name: dendritic shaft namespace: cellular_component def: "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln] xref: GO:0043198 is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0001005 ! dendrite [Term] id: CCO:C0001731 name: lysosomal lumen namespace: cellular_component def: "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228] xref: GO:0043202 is_a: CCO:C0000357 ! vacuolar lumen relationship: part_of CCO:C0000347 ! lysosome [Term] id: CCO:C0001732 name: axon hillock namespace: cellular_component def: "Portion of the neuronal cell soma from which the axon originates." [GOC:nln] xref: GO:0043203 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0001709 ! cell soma [Term] id: CCO:C0001733 name: perikaryon namespace: cellular_component def: "The portion of the cell soma (cell body) that excludes the nucleus." [GOC:jl] synonym: "cell soma cytoplasm" RELATED [] xref: GO:0043204 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0001709 ! cell soma [Term] id: CCO:C0001734 name: fibril namespace: cellular_component def: "Extracellular matrix material consisting of polysaccharides and protein." [PMID:12704238] xref: GO:0043205 is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000203 ! proteinaceous extracellular matrix [Term] id: CCO:C0001735 name: myelin sheath namespace: cellular_component def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:jl, http://en.wikipedia.org/] xref: GO:0043209 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001736 name: compact myelin namespace: cellular_component def: "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh] xref: GO:0043218 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0001735 ! myelin sheath [Term] id: CCO:C0001737 name: lateral loop namespace: cellular_component def: "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh] xref: GO:0043219 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0001735 ! myelin sheath [Term] id: CCO:C0001738 name: Schmidt-Lanterman cleft namespace: cellular_component def: "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman clefts occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh] xref: GO:0043220 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0001735 ! myelin sheath [Term] id: CCO:C0001739 name: SMC/kleisin ring complex namespace: cellular_component def: "A molecular ring complex composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1 and Smc3, and the kleisin protein Scc1." [GOC:jl, PMID:12667442] xref: GO:0043222 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000120 ! condensed chromosome [Term] id: CCO:C0001740 name: cytoplasmic SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "cytoplasmic cullin complex" EXACT [] synonym: "cytoplasmic SCF complex" EXACT [] synonym: "cytoplasmic Skp1/Cul1/F-box protein complex" EXACT [] xref: GO:0043223 is_a: CCO:C0000028 ! cytoplasmic ubiquitin ligase complex is_a: CCO:C0000850 ! SCF ubiquitin ligase complex [Term] id: CCO:C0001741 name: nuclear SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "nuclear cullin complex" EXACT [] synonym: "nuclear SCF complex" EXACT [] synonym: "nuclear Skp1/Cul1/F-box protein complex" EXACT [] xref: GO:0043224 is_a: CCO:C0000027 ! nuclear ubiquitin ligase complex is_a: CCO:C0000850 ! SCF ubiquitin ligase complex [Term] id: CCO:C0001742 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_generic subset: goslim_pir subset: gosubset_prok xref: GO:0043226 is_a: CCO:C0000200 ! cellular_component [Term] id: CCO:C0001745 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok xref: GO:0043229 is_a: CCO:C0001742 ! organelle is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001746 name: extracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] subset: goslim_pir subset: gosubset_prok xref: GO:0043230 is_a: CCO:C0001742 ! organelle is_a: CCO:C0001840 ! extracellular region part [Term] id: CCO:C0001749 name: organelle lumen namespace: cellular_component def: "The volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear membrane lumen." [GOC:jl] xref: GO:0043233 is_a: CCO:C0001366 ! membrane-enclosed lumen is_a: CCO:C0001841 ! organelle part [Term] id: CCO:C0001750 name: protein complex namespace: cellular_component def: "Any protein group composed of two or more subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:go_curators] comment: Note that although at some level almost all cellular components can be thought of as protein complexes, this term is intended to exclude structures composed of the same repeating subunit or subunits, for example microtubules. Protein complexes encompassed by this term are generally not structural, and usually have a defined set of subunits. subset: goslim_generic subset: goslim_pir subset: gosubset_prok xref: GO:0043234 is_a: CCO:C0001492 ! macromolecular complex relationship: location_of CCO:B0001458 ! BCL10_HUMAN relationship: location_of CCO:B0001625 ! PSMD8_HUMAN relationship: location_of CCO:B0002211 ! TBE_HUMAN relationship: location_of CCO:B0006215 ! PSME1_HUMAN relationship: location_of CCO:B0010824 ! BOREA_HUMAN-Phosphoserine165 relationship: location_of CCO:B0010848 ! BRCA1_HUMAN-Phosphoserine1330 relationship: location_of CCO:B0010859 ! BRCA2_HUMAN-Phosphoserine683 relationship: location_of CCO:B0013617 ! PRS4_HUMAN-Phosphotyrosine439 relationship: location_of CCO:B0013618 ! PSA1_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0014540 ! TSC1_HUMAN-Phosphoserine505 relationship: location_of CCO:B0021560 ! PSMD3_HUMAN relationship: location_of CCO:B0023606 ! PSDE_HUMAN relationship: location_of CCO:B0030800 ! PSB2_HUMAN relationship: location_of CCO:B0032651 ! PSMD6_HUMAN relationship: location_of CCO:B0034007 ! PSB7_HUMAN relationship: location_of CCO:B0035474 ! PSA5_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0035478 ! PSB1_HUMAN-Phosphotyrosine150 relationship: location_of CCO:B0035935 ! MEN1_HUMAN relationship: location_of CCO:B0039597 ! PRS10_HUMAN-N-acetylalanine2 relationship: location_of CCO:B0041246 ! PRS7_HUMAN relationship: location_of CCO:B0041255 ! PSMD5_HUMAN relationship: location_of CCO:B0041324 ! PSA4_HUMAN-Phosphoserine13 relationship: location_of CCO:B0041328 ! PSD10_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0041333 ! PSMD4_HUMAN-Phosphoserine358 relationship: location_of CCO:B0041336 ! PSMD9_HUMAN-Phosphoserine129 [Term] id: CCO:C0001751 name: receptor complex namespace: cellular_component def: "Any protein group composed of two or more subunits, which may or may not be identical, which undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok xref: GO:0043235 is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0001752 name: Fanconi anaemia nuclear complex namespace: cellular_component def: "A protein complex composed of the Fanconi anaemia (FA) proteins A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742] synonym: "FA complex" EXACT [] synonym: "FA nuclear complex" EXACT [] synonym: "Fanconi anaemia complex" EXACT [] xref: GO:0043240 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001870 ! nucleoplasm part [Term] id: CCO:C0001753 name: extraorganismal space namespace: cellular_component def: "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl] subset: gosubset_prok xref: GO:0043245 is_a: CCO:C0001840 ! extracellular region part [Term] id: CCO:C0001754 name: megasome namespace: cellular_component def: "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [http://cancerweb.ncl.ac.uk/, PMID:11206117, PMID:1999020] xref: GO:0043246 is_a: CCO:C0000347 ! lysosome [Term] id: CCO:C0001755 name: chloroplast ribosome namespace: cellular_component def: "A ribosome contained within a chloroplast." [GOC:ecd] xref: GO:0043253 is_a: CCO:C0000674 ! plastid ribosome is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000681 ! chloroplast stroma [Term] id: CCO:C0001756 name: laminin complex namespace: cellular_component def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354] subset: goslim_pir xref: GO:0043256 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000228 ! basal lamina [Term] id: CCO:C0001757 name: laminin-8 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0043257 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0001758 name: laminin-9 complex namespace: cellular_component def: "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0043258 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0001759 name: laminin-10 complex namespace: cellular_component def: "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0043259 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0001760 name: laminin-11 complex namespace: cellular_component def: "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0043260 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0001761 name: laminin-12 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains." [GOC:jl, PMID:10842354] xref: GO:0043261 is_a: CCO:C0001756 ! laminin complex [Term] id: CCO:C0001762 name: cellulosome namespace: cellular_component def: "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609] subset: gosubset_prok xref: GO:0043263 is_a: CCO:C0002131 ! extracellular non-membrane-bounded organelle [Term] id: CCO:C0001764 name: ectoplasm namespace: cellular_component def: "Granule free cytoplasm, lying immediately below the plasma membrane." [http://cancerweb.ncl.ac.uk/] xref: GO:0043265 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001765 name: RAVE complex namespace: cellular_component def: "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802] synonym: "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes" BROAD [] xref: GO:0043291 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001766 name: contractile fiber namespace: cellular_component def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] synonym: "contractile fibre" EXACT [] synonym: "muscle fiber" BROAD [] synonym: "muscle fibre" BROAD [] xref: GO:0043292 is_a: CCO:C0001863 ! cytoplasmic part relationship: location_of CCO:B0001802 ! CD5R1_HUMAN [Term] id: CCO:C0001767 name: apoptosome namespace: cellular_component def: "A multisubunit protein complex involved in the activation of apoptosis. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137] xref: GO:0043293 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0001768 name: mitochondrial glutamate synthase complex (NADH) namespace: cellular_component def: "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] xref: GO:0043294 is_a: CCO:C0001115 ! glutamate synthase complex (NADH) is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0000342 ! mitochondrial matrix [Term] id: CCO:C0001769 name: apical junction complex namespace: cellular_component def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, PMID:12525486, PMID:15196556] xref: GO:0043296 is_a: CCO:C0000463 ! intercellular junction relationship: part_of CCO:C0000782 ! apicolateral plasma membrane [Term] id: CCO:C0001770 name: mating projection tip namespace: cellular_component def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc] synonym: "conjugation tube tip" NARROW [] synonym: "shmoo tip" NARROW [] xref: GO:0043332 is_a: CCO:C0001007 ! site of polarized growth is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0000488 ! mating projection [Term] id: CCO:C0001771 name: pre-T cell receptor complex namespace: cellular_component def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149 "Fundamental Immunology", PMID:12220932] synonym: "pre-T lymphocyte receptor complex" EXACT [] synonym: "pre-T-cell receptor complex" EXACT [] synonym: "pre-T-lymphocyte receptor complex" EXACT [] synonym: "pre-TCR complex" EXACT [] xref: GO:0043384 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001772 name: phage terminase complex namespace: cellular_component def: "A complex of a large and small subunit which catalyze the packaging of DNA into phage heads. Note that not all phage terminases have this structure, some exist as single polypeptides." [GOC:mlg] xref: GO:0043493 is_a: CCO:C0001599 ! host cell cytoplasm part is_a: CCO:C0001750 ! protein complex [Term] id: CCO:C0001773 name: Rik1-E3 ubiquitin ligase complex namespace: cellular_component def: "A protein complex that consists of (minimally) cullin, RING finger, methyltransferase, Rik1 WD repeat protein, Raf1 and Raf2. Required to regulate heterchromatin formation by RNAi and for histone H3K9 methylation." [GOC:jl, PMID:16024659, PMID:16040243] synonym: "Rik1 E3 ubiquitin ligase complex" EXACT [] xref: GO:0043494 is_a: CCO:C0001252 ! Cul4B-RING ubiquitin ligase complex [Term] id: CCO:C0001774 name: centromere-specific nucleosome namespace: cellular_component def: "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641] synonym: "centromere specific nucleosome" EXACT [] synonym: "centromeric nucleosome" EXACT [] xref: GO:0043505 is_a: CCO:C0000113 ! nucleosome relationship: part_of CCO:C0000158 ! inner kinetochore of condensed chromosome [Term] id: CCO:C0001775 name: activin A complex namespace: cellular_component def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'. xref: GO:0043509 xref: GO:0048181 is_a: CCO:C0001981 ! activin complex [Term] id: CCO:C0001776 name: activin B complex namespace: cellular_component def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. xref: GO:0043510 xref: GO:0048182 is_a: CCO:C0001981 ! activin complex [Term] id: CCO:C0001777 name: inhibin complex namespace: cellular_component def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl] comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. subset: goslim_pir xref: GO:0043511 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0001778 name: inhibin A complex namespace: cellular_component def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl] comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. xref: GO:0043512 is_a: CCO:C0001777 ! inhibin complex relationship: location_of CCO:B0001485 ! INHA_HUMAN [Term] id: CCO:C0001779 name: inhibin B complex namespace: cellular_component def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl] comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. xref: GO:0043513 is_a: CCO:C0001777 ! inhibin complex [Term] id: CCO:C0001780 name: interleukin-12 complex namespace: cellular_component def: "Secreted heterodimeric cytokine complex composed of an interleukin-12 alpha and an interleukin-12 beta subunit." [GOC:ebc] synonym: "IL-12 complex" EXACT [] xref: GO:0043514 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0001781 name: tRNA methyltransferase complex namespace: cellular_component def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl] subset: goslim_pir xref: GO:0043527 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001782 name: tRNA (m2G10) methyltransferase complex namespace: cellular_component def: "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842] xref: GO:0043528 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001781 ! tRNA methyltransferase complex [Term] id: CCO:C0001783 name: GET complex namespace: cellular_component def: "A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins." [PMID:16269340] synonym: "Golgi to ER Traffic complex" EXACT [] xref: GO:0043529 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001851 ! endoplasmic reticulum part [Term] id: CCO:C0001784 name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex namespace: cellular_component def: "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, InterPro:SO] xref: GO:0043540 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0001785 name: UDP-N-acetylglucosamine transferase complex namespace: cellular_component def: "A heterooligomeric complex that in yeast is composed of a catalytic subunit, Alg13p, and an anchoring subunit, Alg14p. Catalyzes the second step of dolichyl-linked oligosaccharide synthesis of GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc." [PMID:15615718, PMID:16100110, PMID:16100113] comment: See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'. xref: GO:0043541 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001851 ! endoplasmic reticulum part relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0001786 name: Ku70:Ku80 complex namespace: cellular_component def: "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983, UniProtKB:P12956] synonym: "Ku70:Ku80 heterodimer" EXACT [] xref: GO:0043564 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001787 name: bacterial nucleoid namespace: cellular_component def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl] subset: gosubset_prok xref: GO:0043590 is_a: CCO:C0000563 ! nucleoid [Term] id: CCO:C0001788 name: endospore external encapsulating structure namespace: cellular_component def: "The structures that lie outside the inner membrane and surround the entire endospore." [GOC:go_curators] subset: goslim_pir xref: GO:0043591 is_a: CCO:C0000999 ! external encapsulating structure [Term] id: CCO:C0001789 name: exosporium namespace: cellular_component def: "The outer-most layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg] subset: gosubset_prok synonym: "epispore" RELATED [] synonym: "exospore" RELATED [] xref: GO:0043592 is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0001788 ! endospore external encapsulating structure [Term] id: CCO:C0001790 name: endospore coat namespace: cellular_component def: "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg] subset: gosubset_prok xref: GO:0043593 is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0001788 ! endospore external encapsulating structure [Term] id: CCO:C0001791 name: outer endospore membrane namespace: cellular_component def: "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg] subset: gosubset_prok xref: GO:0043594 is_a: CCO:C0000898 ! outer membrane is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0001788 ! endospore external encapsulating structure [Term] id: CCO:C0001792 name: endospore cortex namespace: cellular_component def: "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg] subset: gosubset_prok xref: GO:0043595 is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0001788 ! endospore external encapsulating structure [Term] id: CCO:C0001793 name: nuclear replication fork namespace: cellular_component def: "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] synonym: "replication fork (sensu Eukaryota)" EXACT [] xref: GO:0043596 is_a: CCO:C0000265 ! replication fork is_a: CCO:C0001873 ! nuclear chromosome part [Term] id: CCO:C0001794 name: cytoplasmic replication fork namespace: cellular_component def: "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] synonym: "replication fork (sensu Bacteria and Archaea)" EXACT [] xref: GO:0043597 is_a: CCO:C0000265 ! replication fork is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000041 ! cytoplasmic chromosome [Term] id: CCO:C0001795 name: cytoplasmic DNA replication factor C complex namespace: cellular_component def: "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [GOC:mtg_sensu, PMID:14646196, PMID:16172520] synonym: "DNA replication factor C complex (sensu Bacteria and Archaea)" EXACT [] xref: GO:0043598 is_a: CCO:C0000268 ! DNA replication factor C complex is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001797 ! cytoplasmic replisome [Term] id: CCO:C0001796 name: nuclear DNA replication factor C complex namespace: cellular_component def: "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species." [GOC:mtg_sensu, PMID:14614842] synonym: "DNA replication factor C complex (sensu Eukaryota)" EXACT [] xref: GO:0043599 is_a: CCO:C0000268 ! DNA replication factor C complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0001798 ! nuclear replisome [Term] id: CCO:C0001797 name: cytoplasmic replisome namespace: cellular_component def: "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins." [GOC:jl, GOC:mtg_sensu] synonym: "replisome (sensu Bacteria and Archaea)" EXACT [] xref: GO:0043600 is_a: CCO:C0001072 ! replisome is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001794 ! cytoplasmic replication fork [Term] id: CCO:C0001798 name: nuclear replisome namespace: cellular_component def: "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] synonym: "replisome (sensu Eukaryota)" EXACT [] xref: GO:0043601 is_a: CCO:C0001072 ! replisome is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0001793 ! nuclear replication fork [Term] id: CCO:C0001799 name: multi-eIF complex namespace: cellular_component def: "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preintiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [GOC:krc] synonym: "multifactor translation initiation factor (eIF) complex" EXACT [] xref: GO:0043614 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001800 name: delta DNA polymerase complex namespace: cellular_component def: "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614] synonym: "delta-DNA polymerase complex" EXACT [] xref: GO:0005659 xref: GO:0043625 is_a: CCO:C0001651 ! DNA polymerase complex is_a: CCO:C0001873 ! nuclear chromosome part relationship: part_of CCO:C0001798 ! nuclear replisome [Term] id: CCO:C0001801 name: PCNA complex namespace: cellular_component def: "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735] subset: gosubset_prok synonym: "proliferating cell nuclear antigen complex" EXACT [] synonym: "sliding clamp" BROAD [] xref: GO:0043626 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001802 name: extracellular space of host namespace: cellular_component def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc] subset: gosubset_prok synonym: "host extracellular space" EXACT [] xref: GO:0043655 is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000849 ! host [Term] id: CCO:C0001803 name: intracellular region of host namespace: cellular_component def: "That space within the plasma membrane of a host cell." [GOC:cc] subset: gosubset_prok synonym: "host intracellular" EXACT [] xref: GO:0043656 is_a: CCO:C0001588 ! host cell part [Term] id: CCO:C0001804 name: host cell namespace: cellular_component def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl] subset: gosubset_prok xref: GO:0043657 is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000849 ! host [Term] id: CCO:C0001805 name: host symbiosome namespace: cellular_component def: "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [GOC:cc] subset: gosubset_prok xref: GO:0043658 is_a: CCO:C0001599 ! host cell cytoplasm part is_a: CCO:C0002126 ! host intracellular membrane-bounded organelle [Term] id: CCO:C0001806 name: symbiosome namespace: cellular_component def: "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [GOC:cc] subset: gosubset_prok xref: GO:0043659 is_a: CCO:C0000983 ! endocytic vesicle [Term] id: CCO:C0001807 name: bacteroid-containing symbiosome namespace: cellular_component def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [GOC:cc] subset: gosubset_prok xref: GO:0043660 is_a: CCO:C0001806 ! symbiosome [Term] id: CCO:C0001808 name: peribacteroid membrane namespace: cellular_component def: "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] subset: gosubset_prok xref: GO:0043661 is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001807 ! bacteroid-containing symbiosome [Term] id: CCO:C0001809 name: peribacteroid fluid namespace: cellular_component def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [GOC:cc] subset: gosubset_prok xref: GO:0043662 is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001807 ! bacteroid-containing symbiosome [Term] id: CCO:C0001810 name: host bacteroid-containing symbiosome namespace: cellular_component def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [GOC:cc] subset: gosubset_prok xref: GO:0043663 is_a: CCO:C0001805 ! host symbiosome [Term] id: CCO:C0001811 name: host peribacteroid membrane namespace: cellular_component def: "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] subset: gosubset_prok xref: GO:0043664 is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001810 ! host bacteroid-containing symbiosome [Term] id: CCO:C0001812 name: host peribacteroid fluid namespace: cellular_component def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [GOC:cc] subset: gosubset_prok xref: GO:0043665 is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001810 ! host bacteroid-containing symbiosome [Term] id: CCO:C0001813 name: pollen wall namespace: cellular_component def: "The complex wall surrounding a pollen grain." [GOC:fz] comment: Note that this term is a child of 'extracellular matrix part ; GO:0044420' rather than the more specific 'extracellular matrix (sensu Magnoliophyta) ; GO:0048196', because unlike the usual plant cell wall, the pollen wall does not contain a middle lamella, as specified in the definition of 'extracellular matrix (sensu Magnoliophyta) ; GO:0048196'. synonym: "micrsopore wall" EXACT [] xref: GO:0043667 is_a: CCO:C0001839 ! extracellular matrix part [Term] id: CCO:C0001814 name: exine namespace: cellular_component def: "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that the exine is highly resistant to strong acids and bases. xref: GO:0043668 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001813 ! pollen wall [Term] id: CCO:C0001815 name: ectexine namespace: cellular_component def: "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'. xref: GO:0043669 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001814 ! exine [Term] id: CCO:C0001816 name: foot layer namespace: cellular_component def: "The inner layer of the ectexine." [http://www.mobot.org/MOBOT/research/APweb/] synonym: "nexine 1" EXACT [] xref: GO:0043670 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001815 ! ectexine [Term] id: CCO:C0001817 name: endexine namespace: cellular_component def: "The inner part of the exine, which stains." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'. xref: GO:0043671 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001814 ! exine [Term] id: CCO:C0001818 name: nexine namespace: cellular_component def: "The inner, non-sculptured part of the exine which lies below the sexine." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'. xref: GO:0043672 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001814 ! exine [Term] id: CCO:C0001819 name: sexine namespace: cellular_component def: "The outer, sculptured layer of the exine, which lies above the nexine." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'. xref: GO:0043673 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001814 ! exine [Term] id: CCO:C0001820 name: columella namespace: cellular_component def: "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [http://www.mobot.org/MOBOT/research/APweb/] synonym: "sexine 1" EXACT [] xref: GO:0043674 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001819 ! sexine [Term] id: CCO:C0001821 name: sculpture element namespace: cellular_component def: "The third layer of the sexine." [http://www.mobot.org/MOBOT/research/APweb/] xref: GO:0043675 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001819 ! sexine [Term] id: CCO:C0001822 name: tectum namespace: cellular_component def: "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [http://www.mobot.org/MOBOT/research/APweb/] synonym: "sexine 2" EXACT [] xref: GO:0043676 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001819 ! sexine [Term] id: CCO:C0001823 name: germination pore namespace: cellular_component def: "A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [http://en.wikipedia.org/] synonym: "germ pore" EXACT [] xref: GO:0043677 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001813 ! pollen wall [Term] id: CCO:C0001824 name: intine namespace: cellular_component def: "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material. xref: GO:0043678 is_a: CCO:C0001839 ! extracellular matrix part relationship: part_of CCO:C0001813 ! pollen wall [Term] id: CCO:C0001825 name: nerve terminal namespace: cellular_component def: "The nerve ending is the structure in which the distal end of the axon of a nerve fiber terminates. Sensory nerve endings are classified as either free or encapsulated. The free nerve ending are the most common type of nerve ending, and are most frequently found in the skin." [GOC:ef] synonym: "nerve ending" EXACT [] xref: GO:0043679 is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0001707 ! neuron projection [Term] id: CCO:C0001826 name: filiform apparatus namespace: cellular_component def: "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208] xref: GO:0043680 is_a: CCO:C0001845 ! cell wall part [Term] id: CCO:C0001827 name: type IV protein secretion system complex namespace: cellular_component def: "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of nucleoprotein DNA conjugation intermediates or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s)." [GOC:ml] subset: gosubset_prok synonym: "T4SS complex" EXACT [] xref: GO:0043684 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001828 name: iridosome namespace: cellular_component def: "A tissue-specific, membrane bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance." [GOC:mh] synonym: "reflecting platelet" EXACT [] xref: GO:0043698 is_a: CCO:C0002006 ! pigment granule [Term] id: CCO:C0001829 name: leucosome namespace: cellular_component def: "A tissue-specific, membrane bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast." [GOC:mh] synonym: "refractosome" EXACT [] xref: GO:0043699 is_a: CCO:C0002006 ! pigment granule [Term] id: CCO:C0001830 name: pterinosome namespace: cellular_component def: "A tissue-specific, membrane bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] xref: GO:0043700 is_a: CCO:C0002006 ! pigment granule [Term] id: CCO:C0001831 name: cyanosome namespace: cellular_component def: "A tissue-specific, membrane bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance." [GOC:mh] xref: GO:0043701 is_a: CCO:C0002006 ! pigment granule [Term] id: CCO:C0001832 name: carotenoid vesicle namespace: cellular_component def: "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vescicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] xref: GO:0043702 is_a: CCO:C0001235 ! cytoplasmic vesicle [Term] id: CCO:C0001833 name: telomere binding complex namespace: cellular_component def: "A complex composed of four polypeptides: a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA) that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species." [PMID:15353591] subset: gosubset_prok synonym: "telomere complex" EXACT [] xref: GO:0043769 is_a: CCO:C0001846 ! chromosomal part relationship: part_of CCO:C0000108 ! chromosome, telomeric region [Term] id: CCO:C0001834 name: DNA polymerase III, proof-reading complex namespace: cellular_component def: "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity." [http://en.wikipedia.org/wiki/Pol_III, IMG:01721] subset: gosubset_prok synonym: "DNA polymerase III, proof-reading subcomplex" EXACT [] synonym: "DNA polymerase III, proofreading subcomplex" EXACT [] xref: GO:0043845 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000604 ! DNA polymerase III complex [Term] id: CCO:C0001835 name: DNA polymerase III, DnaX complex namespace: cellular_component def: "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:12940977] subset: gosubset_prok synonym: "clamp loader complex" BROAD [] synonym: "DNA polymerase III, clamp loader complex" EXACT [] synonym: "DNA polymerase III, DnaX subcomplex" EXACT [] xref: GO:0043846 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000604 ! DNA polymerase III complex [Term] id: CCO:C0001836 name: DNA polymerase III, DnaX complex, chi/psi subcomplex namespace: cellular_component def: "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III DnaX complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB)." [IMG:01719, PMID:12940977] subset: gosubset_prok synonym: "DNA polymerase III, clamp loader chi/psi subcomplex" EXACT [] xref: GO:0043847 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0001835 ! DNA polymerase III, DnaX complex [Term] id: CCO:C0001837 name: RecFOR complex namespace: cellular_component def: "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair." [IMG:01764, PMID:12769856] subset: gosubset_prok xref: GO:0043850 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001846 ! chromosomal part [Term] id: CCO:C0001838 name: methanol-CoM methyltransferase complex namespace: cellular_component def: "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol." [IMG:01437, MetaCyc:CPLX-421, PMID:9363780] subset: gosubset_prok synonym: "methanol-coenzyme M methyltransferase complex" EXACT [] synonym: "methanol: coenzyme M methyltransferase complex" EXACT [] synonym: "methanol: CoM methyltransferase complex" EXACT [] synonym: "methanol:coenzyme M methyltransferase complex" EXACT [] synonym: "methanol:CoM methyltransferase complex" EXACT [] xref: GO:0043853 xref: MetaCyc:CPLX-421 is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001839 name: extracellular matrix part namespace: cellular_component def: "Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl] subset: gosubset_prok xref: GO:0044420 is_a: CCO:C0000200 ! cellular_component relationship: part_of CCO:C0001109 ! extracellular matrix [Term] id: CCO:C0001840 name: extracellular region part namespace: cellular_component def: "Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl] subset: gosubset_prok xref: GO:0044421 is_a: CCO:C0000200 ! cellular_component relationship: part_of CCO:C0000201 ! extracellular region [Term] id: CCO:C0001841 name: organelle part namespace: cellular_component def: "Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl] subset: gosubset_prok xref: GO:0044422 is_a: CCO:C0000200 ! cellular_component relationship: part_of CCO:C0001742 ! organelle [Term] id: CCO:C0001842 name: virion part namespace: cellular_component def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl] xref: GO:0044423 is_a: CCO:C0000200 ! cellular_component relationship: part_of CCO:C0000852 ! virion [Term] id: CCO:C0001843 name: intracellular part namespace: cellular_component def: "Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl] subset: gosubset_prok xref: GO:0044424 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0000242 ! intracellular [Term] id: CCO:C0001844 name: membrane part namespace: cellular_component def: "Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl] subset: gosubset_prok xref: GO:0044425 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0000766 ! membrane [Term] id: CCO:C0001845 name: cell wall part namespace: cellular_component def: "Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl] subset: gosubset_prok xref: GO:0044426 is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0000239 ! cell wall [Term] id: CCO:C0001846 name: chromosomal part namespace: cellular_component def: "Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl] subset: gosubset_prok synonym: "chromosomal component" EXACT [] synonym: "chromosome component" EXACT [] synonym: "chromosome part" EXACT [] xref: GO:0044427 is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000296 ! chromosome [Term] id: CCO:C0001847 name: nuclear part namespace: cellular_component def: "Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl] synonym: "nucleus component" EXACT [] xref: GO:0044428 is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000252 ! nucleus [Term] id: CCO:C0001848 name: mitochondrial part namespace: cellular_component def: "Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl] synonym: "mitochondrion component" EXACT [] xref: GO:0044429 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000325 ! mitochondrion [Term] id: CCO:C0001849 name: cytoskeletal part namespace: cellular_component def: "Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl] synonym: "cytoskeleton component" EXACT [] xref: GO:0044430 is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000421 ! cytoskeleton [Term] id: CCO:C0001850 name: Golgi apparatus part namespace: cellular_component def: "Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] synonym: "Golgi component" EXACT [] xref: GO:0044431 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000375 ! Golgi apparatus [Term] id: CCO:C0001851 name: endoplasmic reticulum part namespace: cellular_component def: "Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl] synonym: "ER component" EXACT [] xref: GO:0044432 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000364 ! endoplasmic reticulum [Term] id: CCO:C0001852 name: cytoplasmic vesicle part namespace: cellular_component def: "Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl] subset: gosubset_prok xref: GO:0044433 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0001235 ! cytoplasmic vesicle [Term] id: CCO:C0001853 name: chloroplast part namespace: cellular_component def: "Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl] xref: GO:0044434 is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0000636 ! chloroplast [Term] id: CCO:C0001854 name: plastid part namespace: cellular_component def: "Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl] subset: gosubset_prok xref: GO:0044435 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000664 ! plastid [Term] id: CCO:C0001855 name: thylakoid part namespace: cellular_component def: "Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl] subset: gosubset_prok xref: GO:0044436 is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000689 ! thylakoid [Term] id: CCO:C0001856 name: vacuolar part namespace: cellular_component def: "Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl] subset: gosubset_prok synonym: "vacuole component" EXACT [] xref: GO:0044437 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000355 ! vacuole [Term] id: CCO:C0001857 name: microbody part namespace: cellular_component def: "Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl] xref: GO:0044438 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0001652 ! microbody [Term] id: CCO:C0001858 name: peroxisomal part namespace: cellular_component def: "Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl] synonym: "peroxisome component" EXACT [] xref: GO:0044439 is_a: CCO:C0001857 ! microbody part relationship: part_of CCO:C0000359 ! peroxisome [Term] id: CCO:C0001859 name: endosomal part namespace: cellular_component def: "Any constituent part of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [GOC:jl] synonym: "endosome component" EXACT [] xref: GO:0044440 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000351 ! endosome [Term] id: CCO:C0001860 name: cilium part namespace: cellular_component def: "Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:jl] xref: GO:0044441 is_a: CCO:C0001865 ! intracellular organelle part is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0000481 ! cilium [Term] id: CCO:C0001861 name: microtubule-based flagellum part namespace: cellular_component def: "Any constituent part of a microtubule-based flagellum, a long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules." [GOC:jl, GOC:mtg_sensu] synonym: "flagellar part (sensu Eukaryota)" EXACT [] synonym: "flagellum part (sensu Eukaryota)" EXACT [] xref: GO:0044442 is_a: CCO:C0001865 ! intracellular organelle part is_a: CCO:C0001878 ! flagellum part relationship: part_of CCO:C0000629 ! microtubule-based flagellum [Term] id: CCO:C0001862 name: fimbrial part namespace: cellular_component def: "Any constituent part of a fimbrium, a proteinaceous hair-like appendage on the surface of bacteria; range from 2-8 nm in diameter." [GOC:jl] subset: gosubset_prok synonym: "fimbrium component" EXACT [] xref: GO:0044443 is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000562 ! fimbrium [Term] id: CCO:C0001863 name: cytoplasmic part namespace: cellular_component def: "Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl] subset: gosubset_prok synonym: "cytoplasm component" EXACT [] xref: GO:0044444 is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0000324 ! cytoplasm [Term] id: CCO:C0001864 name: cytosolic part namespace: cellular_component def: "Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl] subset: gosubset_prok synonym: "cytosol component" EXACT [] xref: GO:0044445 is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000397 ! cytosol [Term] id: CCO:C0001865 name: intracellular organelle part namespace: cellular_component def: "A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl] subset: gosubset_prok xref: GO:0044446 is_a: CCO:C0001841 ! organelle part is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0001745 ! intracellular organelle [Term] id: CCO:C0001866 name: axoneme part namespace: cellular_component def: "Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [GOC:jl] xref: GO:0044447 is_a: CCO:C0001865 ! intracellular organelle part is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0000482 ! axoneme [Term] id: CCO:C0001867 name: cell cortex part namespace: cellular_component def: "Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl] xref: GO:0044448 is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000489 ! cell cortex [Term] id: CCO:C0001868 name: contractile fiber part namespace: cellular_component def: "Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl] synonym: "contractile fibre component" EXACT [] synonym: "muscle fiber component" BROAD [] synonym: "muscle fibre component" BROAD [] xref: GO:0044449 is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001766 ! contractile fiber [Term] id: CCO:C0001869 name: microtubule organizing center part namespace: cellular_component def: "Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl] synonym: "microtubule organizing centre component" EXACT [] synonym: "MTOC component" EXACT [] xref: GO:0044450 is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0000385 ! microtubule organizing center [Term] id: CCO:C0001870 name: nucleoplasm part namespace: cellular_component def: "Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl] xref: GO:0044451 is_a: CCO:C0001847 ! nuclear part relationship: part_of CCO:C0000262 ! nucleoplasm [Term] id: CCO:C0001871 name: nucleolar part namespace: cellular_component def: "Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl] synonym: "nucleolus component" EXACT [] xref: GO:0044452 is_a: CCO:C0001847 ! nuclear part relationship: part_of CCO:C0000320 ! nucleolus [Term] id: CCO:C0001872 name: nuclear membrane part namespace: cellular_component def: "Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl] xref: GO:0044453 is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001847 ! nuclear part relationship: part_of CCO:C0001358 ! nuclear membrane [Term] id: CCO:C0001873 name: nuclear chromosome part namespace: cellular_component def: "Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell." [GOC:jl] xref: GO:0044454 is_a: CCO:C0001846 ! chromosomal part is_a: CCO:C0001847 ! nuclear part relationship: part_of CCO:C0000040 ! nuclear chromosome [Term] id: CCO:C0001874 name: mitochondrial membrane part namespace: cellular_component def: "Any constituent part of the mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl] xref: GO:0044455 is_a: CCO:C0001844 ! membrane part is_a: CCO:C0001848 ! mitochondrial part relationship: part_of CCO:C0001359 ! mitochondrial membrane [Term] id: CCO:C0001875 name: synapse part namespace: cellular_component def: "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl] xref: GO:0044456 is_a: CCO:C0000200 ! cellular_component relationship: part_of CCO:C0001900 ! synapse [Term] id: CCO:C0001876 name: cell septum part namespace: cellular_component def: "Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl] xref: GO:0044457 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0001008 ! cell septum [Term] id: CCO:C0001877 name: plasma membrane part namespace: cellular_component def: "Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl] subset: gosubset_prok xref: GO:0044459 is_a: CCO:C0001844 ! membrane part relationship: part_of CCO:C0000444 ! plasma membrane [Term] id: CCO:C0001878 name: flagellum part namespace: cellular_component def: "Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl] subset: gosubset_prok synonym: "flagellum component" EXACT [] xref: GO:0044460 is_a: CCO:C0001881 ! cell projection part relationship: part_of CCO:C0000896 ! flagellum [Term] id: CCO:C0001879 name: flagellin-based flagellum part namespace: cellular_component def: "Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential." [GOC:jl, GOC:mtg_sensu] subset: gosubset_prok synonym: "flagellar part (sensu Bacteria)" EXACT [] synonym: "flagellum part (sensu Bacteria)" EXACT [] xref: GO:0044461 is_a: CCO:C0001878 ! flagellum part relationship: part_of CCO:C0000561 ! flagellin-based flagellum [Term] id: CCO:C0001880 name: external encapsulating structure part namespace: cellular_component def: "Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:jl] subset: gosubset_prok xref: GO:0044462 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0000999 ! external encapsulating structure [Term] id: CCO:C0001881 name: cell projection part namespace: cellular_component def: "Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl] subset: gosubset_prok xref: GO:0044463 is_a: CCO:C0001882 ! cell part relationship: part_of CCO:C0001706 ! cell projection [Term] id: CCO:C0001882 name: cell part namespace: cellular_component def: "Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl] subset: goslim_pir subset: gosubset_prok xref: GO:0044464 is_a: CCO:C0000200 ! cellular_component relationship: part_of CCO:C0000243 ! cell [Term] id: CCO:C0001883 name: chitosome namespace: cellular_component def: "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:8970154] xref: GO:0045009 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0001884 name: mitochondrial degradosome namespace: cellular_component def: "The mitochondrial degradosome (mtEXO) is a three-protein complex which has a 3' to 5' exoribonuclease activity and participates in intron-independent turnover and processing of mitochondrial transcripts." [PMID:10397341, PMID:9829834] xref: GO:0045025 is_a: CCO:C0001848 ! mitochondrial part [Term] id: CCO:C0001885 name: interleukin-18 receptor complex namespace: cellular_component def: "Complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435] xref: GO:0045092 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001886 name: keratin filament namespace: cellular_component def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363] synonym: "acidic keratin" RELATED [] synonym: "basic/neutral keratin" RELATED [] xref: GO:0045095 is_a: CCO:C0000440 ! intermediate filament [Term] id: CCO:C0001887 name: type III intermediate filament namespace: cellular_component def: "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363] synonym: "desmin" NARROW [] synonym: "glial fibrillary acidic protein" NARROW [] synonym: "peripherin" NARROW [] synonym: "type III intermediate filament associated protein" NARROW [] synonym: "vimentin" NARROW [] xref: GO:0045098 is_a: CCO:C0000440 ! intermediate filament [Term] id: CCO:C0001888 name: intermediate filament cytoskeleton namespace: cellular_component def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363] xref: GO:0045111 is_a: CCO:C0000421 ! cytoskeleton [Term] id: CCO:C0001889 name: pronucleus namespace: cellular_component def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0045120 is_a: CCO:C0000252 ! nucleus [Term] id: CCO:C0001891 name: myosin I complex namespace: cellular_component def: "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839] xref: GO:0045160 is_a: CCO:C0000790 ! unconventional myosin complex [Term] id: CCO:C0001892 name: fusome namespace: cellular_component def: "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] xref: GO:0045169 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001893 name: spectrosome namespace: cellular_component def: "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf] xref: GO:0045170 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle [Term] id: CCO:C0001894 name: intercellular bridge namespace: cellular_component def: "A direct link between the cytoplasms of sister cells that allows cells to communicate with one another. Germline intercellular bridges facilitate the passage of cytoplasmic components between cells during development. Intercellular bridges have also been found connecting somatic cells." [PMID:9635420] xref: GO:0045171 is_a: CCO:C0001840 ! extracellular region part [Term] id: CCO:C0001895 name: germline ring canal namespace: cellular_component def: "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] synonym: "ring canal (sensu Insecta)" EXACT [] xref: GO:0045172 is_a: CCO:C0001894 ! intercellular bridge [Term] id: CCO:C0001896 name: apical part of cell namespace: cellular_component def: "The apical region of a cell." [GOC:bf] subset: goslim_pir xref: GO:0045177 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001897 name: basal part of cell namespace: cellular_component def: "The basal region of a cell." [GOC:bf] subset: goslim_pir xref: GO:0045178 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0001898 name: apical cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] xref: GO:0045179 is_a: CCO:C0001867 ! cell cortex part relationship: part_of CCO:C0001896 ! apical part of cell [Term] id: CCO:C0001899 name: basal cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf] xref: GO:0045180 is_a: CCO:C0001867 ! cell cortex part relationship: part_of CCO:C0001897 ! basal part of cell [Term] id: CCO:C0001900 name: synapse namespace: cellular_component def: "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir synonym: "synaptic junction" EXACT [] xref: GO:0045202 is_a: CCO:C0000200 ! cellular_component relationship: location_of CCO:B0001998 ! Q8TEY4_HUMAN relationship: location_of CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 [Term] id: CCO:C0001901 name: integral to cell outer membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the external outer membrane of the cell. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators, GOC:mtg_sensu] subset: gosubset_prok synonym: "integral to external membrane (sensu Gram-negative Bacteria)" EXACT [] synonym: "integral to external membrane (sensu Proteobacteria)" EXACT [] synonym: "integral to outer membrane (sensu Gram-negative Bacteria)" EXACT [] synonym: "integral to outer membrane (sensu Proteobacteria)" EXACT [] xref: GO:0045203 is_a: CCO:C0000767 ! integral to membrane is_a: CCO:C0001154 ! intrinsic to cell outer membrane [Term] id: CCO:C0001902 name: postsynaptic membrane namespace: cellular_component def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0045211 is_a: CCO:C0000766 ! membrane is_a: CCO:C0001875 ! synapse part relationship: location_of CCO:B0011521 ! DLG1_HUMAN-Phosphoserine301 [Term] id: CCO:C0001903 name: tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "TCA cycle enzyme complex" EXACT [] xref: GO:0045239 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part relationship: location_of CCO:B0001496 ! FUMH_HUMAN [Term] id: CCO:C0001904 name: alpha-ketoglutarate dehydrogenase complex namespace: cellular_component def: "Complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah] subset: gosubset_prok synonym: "2-oxoglutarate dehydrogenase complex" EXACT [] synonym: "dihydrolipoyl dehydrogenase complex" EXACT [] xref: GO:0045240 is_a: CCO:C0001903 ! tricarboxylic acid cycle enzyme complex [Term] id: CCO:C0001905 name: cytosolic alpha-ketoglutarate dehydrogenase complex namespace: cellular_component def: "Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] synonym: "alpha-ketoglutarate dehydrogenase complex (sensu Bacteria)" EXACT [] xref: GO:0045241 is_a: CCO:C0001904 ! alpha-ketoglutarate dehydrogenase complex is_a: CCO:C0001909 ! cytosolic tricarboxylic acid cycle enzyme complex [Term] id: CCO:C0001906 name: isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah] subset: gosubset_prok xref: GO:0045242 is_a: CCO:C0001903 ! tricarboxylic acid cycle enzyme complex [Term] id: CCO:C0001907 name: cytosolic isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "isocitrate dehydrogenase complex (NAD+) (sensu Bacteria)" EXACT [] xref: GO:0045243 is_a: CCO:C0001906 ! isocitrate dehydrogenase complex (NAD+) is_a: CCO:C0001909 ! cytosolic tricarboxylic acid cycle enzyme complex [Term] id: CCO:C0001908 name: succinate-CoA ligase complex (GDP-forming) namespace: cellular_component def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain and found in eukaryotes. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [EC:6.2.1.4, GOC:jl] synonym: "succinate-CoA ligase complex (GDP-forming) (sensu Bacteria)" NARROW [] synonym: "succinate-CoA ligase complex (GDP-forming) (sensu Eukaryota)" NARROW [] xref: GO:0008325 xref: GO:0045244 xref: GO:0045245 is_a: CCO:C0000941 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: CCO:C0001687 ! succinate-CoA ligase complex [Term] id: CCO:C0001909 name: cytosolic tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "TCA cycle enzyme complex (sensu Bacteria)" EXACT [] synonym: "tricarboxylic acid cycle enzyme complex (sensu Bacteria)" EXACT [] xref: GO:0045246 is_a: CCO:C0001903 ! tricarboxylic acid cycle enzyme complex [Term] id: CCO:C0001910 name: cytosolic electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "electron transfer flavoprotein complex (sensu Bacteria)" EXACT [] xref: GO:0045247 is_a: CCO:C0001914 ! electron transfer flavoprotein complex [Term] id: CCO:C0001911 name: cytosolic oxoglutarate dehydrogenase complex namespace: cellular_component def: "A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [GOC:mtg_sensu, UniProtKB:Q60597] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. subset: gosubset_prok synonym: "oxoglutarate dehydrogenase complex (sensu Bacteria)" EXACT [] xref: GO:0045248 is_a: CCO:C0001863 ! cytoplasmic part is_a: CCO:C0001915 ! oxoglutarate dehydrogenase complex [Term] id: CCO:C0001912 name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, UniProtKB:P35816] comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. subset: gosubset_prok synonym: "pyruvate dehydrogenase (lipoamide) phosphatase complex (sensu Bacteria)" EXACT [] xref: GO:0045249 is_a: CCO:C0001916 ! pyruvate dehydrogenase (lipoamide) phosphatase complex [Term] id: CCO:C0001913 name: cytosolic pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order." [GOC:mtg_sensu, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. subset: gosubset_prok synonym: "pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)" EXACT [] synonym: "pyruvate dehydrogenase complex (sensu Bacteria)" EXACT [] xref: GO:0045250 is_a: CCO:C0001917 ! pyruvate dehydrogenase complex [Term] id: CCO:C0001914 name: electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok xref: GO:0045251 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001915 name: oxoglutarate dehydrogenase complex namespace: cellular_component def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [UniProtKB:Q60597] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. subset: goslim_pir subset: gosubset_prok synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT [] xref: GO:0045252 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001916 name: pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [UniProtKB:P35816] comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. subset: goslim_pir subset: gosubset_prok xref: GO:0045253 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001917 name: pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. subset: goslim_pir subset: gosubset_prok synonym: "dihydrolipoyl dehydrogenase complex" BROAD [] synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT [] xref: GO:0009364 xref: GO:0045254 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001918 name: succinate dehydrogenase complex (ubiquinone) namespace: cellular_component def: "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, ISBN:0198547684] subset: gosubset_prok xref: GO:0045257 is_a: CCO:C0001941 ! succinate dehydrogenase complex [Term] id: CCO:C0001919 name: plasma membrane succinate dehydrogenase complex (ubiquinone) namespace: cellular_component def: "The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "succinate dehydrogenase complex (ubiquinone) (sensu Bacteria)" EXACT [] xref: GO:0045258 is_a: CCO:C0001918 ! succinate dehydrogenase complex (ubiquinone) is_a: CCO:C0001942 ! plasma membrane succinate dehydrogenase complex [Term] id: CCO:C0001920 name: proton-transporting ATP synthase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [EC:3.6.3.14, ISBN:0198547684, ISBN:0716743663] subset: gosubset_prok synonym: "hydrogen-translocating F-type ATPase complex" EXACT [] synonym: "hydrogen-transporting ATP synthase complex" EXACT [] synonym: "proton-transporting F-type ATPase complex" RELATED [] xref: GO:0045255 xref: GO:0045259 is_a: CCO:C0000792 ! proton-transporting two-sector ATPase complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001921 name: plasma membrane proton-transporting ATP synthase complex namespace: cellular_component def: "A proton-transporting ATP synthase complex found in the plasma membrane." [GOC:mah, GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "hydrogen-translocating F-type ATPase complex (sensu Bacteria)" EXACT [] synonym: "hydrogen-transporting ATP synthase" EXACT [] synonym: "plasma membrane hydrogen-translocating F-type ATPase complex" EXACT [] synonym: "proton-transporting ATP synthase complex (sensu Bacteria)" EXACT [] xref: GO:0045256 xref: GO:0045260 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001920 ! proton-transporting ATP synthase complex [Term] id: CCO:C0001922 name: proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, F1 sector" EXACT [] xref: GO:0045261 is_a: CCO:C0001548 ! proton-transporting two-sector ATPase complex, catalytic domain is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0001920 ! proton-transporting ATP synthase complex [Term] id: CCO:C0001923 name: plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled." [GOC:mah, GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'plasma membrane ; GO:0005886'. subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, F1 sector (sensu Bacteria)" EXACT [] synonym: "proton-transporting ATP synthase complex, catalytic core F(1) (sensu Bacteria)" EXACT [] xref: GO:0045262 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001922 ! proton-transporting ATP synthase complex, catalytic core F(1) relationship: part_of CCO:C0001921 ! plasma membrane proton-transporting ATP synthase complex [Term] id: CCO:C0001924 name: proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" NARROW [] synonym: "hydrogen-transporting ATP synthase, F0 sector" EXACT [] synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" EXACT [] xref: GO:0045263 is_a: CCO:C0001547 ! proton-transporting two-sector ATPase complex, proton-transporting domain is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0001920 ! proton-transporting ATP synthase complex [Term] id: CCO:C0001925 name: plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins." [GOC:mah, GOC:mtg_sensu, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, F0 sector (sensu Bacteria)" EXACT [] synonym: "proton-transporting ATP synthase complex, coupling factor F(0) (sensu Bacteria)" EXACT [] synonym: "proton-transporting ATP synthase complex, coupling factor F(o) (sensu Bacteria)" EXACT [] xref: GO:0045264 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001924 ! proton-transporting ATP synthase complex, coupling factor F(o) relationship: part_of CCO:C0001921 ! plasma membrane proton-transporting ATP synthase complex [Term] id: CCO:C0001926 name: proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, stator stalk" EXACT [] xref: GO:0045265 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0001924 ! proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: CCO:C0001927 name: plasma membrane proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, stator stalk (sensu Bacteria)" EXACT [] synonym: "proton-transporting ATP synthase, stator stalk (sensu Bacteria)" EXACT [] xref: GO:0045266 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001926 ! proton-transporting ATP synthase, stator stalk relationship: part_of CCO:C0001925 ! plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: CCO:C0001928 name: proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, catalytic core" EXACT [] xref: GO:0045267 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0001922 ! proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: CCO:C0001929 name: plasma membrane proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, catalytic core (sensu Bacteria)" EXACT [] synonym: "proton-transporting ATP synthase, catalytic core (sensu Bacteria)" EXACT [] xref: GO:0045268 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001928 ! proton-transporting ATP synthase, catalytic core relationship: part_of CCO:C0001923 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: CCO:C0001930 name: proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, central stalk" EXACT [] xref: GO:0045269 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0001922 ! proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: CCO:C0001931 name: plasma membrane proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, central stalk (sensu Bacteria)" EXACT [] synonym: "proton-transporting ATP synthase, central stalk (sensu Bacteria)" EXACT [] xref: GO:0045270 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001930 ! proton-transporting ATP synthase, central stalk relationship: part_of CCO:C0001923 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: CCO:C0001932 name: respiratory chain complex I namespace: cellular_component def: "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:jic, ISBN:0716749556] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'. subset: gosubset_prok synonym: "NADH dehydrogenase (ubiquinone) complex" EXACT [] synonym: "NADH dehydrogenase complex (ubiquinone)" EXACT [] synonym: "NADH-Q oxidoreductase complex" EXACT [] xref: GO:0045271 xref: GO:0045279 is_a: CCO:C0002063 ! NADH dehydrogenase complex [Term] id: CCO:C0001933 name: plasma membrane respiratory chain complex I namespace: cellular_component def: "A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "NADH dehydrogenase (ubiquinone) complex (sensu Bacteria)" EXACT [] synonym: "respiratory chain complex I (sensu Bacteria)" EXACT [] xref: GO:0045272 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001932 ! respiratory chain complex I [Term] id: CCO:C0001934 name: respiratory chain complex II namespace: cellular_component def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok xref: GO:0045273 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001935 name: plasma membrane respiratory chain complex II namespace: cellular_component def: "A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "respiratory chain complex II (sensu Bacteria)" EXACT [] xref: GO:0045274 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001934 ! respiratory chain complex II [Term] id: CCO:C0001936 name: respiratory chain complex III namespace: cellular_component def: "A part of the respiratory chain, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok synonym: "ubiquinol-cytochrome c oxidoreductase complex" EXACT [] synonym: "ubiquinol-cytochrome-c reductase complex" EXACT [] xref: GO:0045275 xref: GO:0045285 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001937 name: plasma membrane respiratory chain complex III namespace: cellular_component def: "A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "plasma membrane ubiquinol-cytochrome-c reductase complex" EXACT [] synonym: "respiratory chain complex III (sensu Bacteria)" EXACT [] synonym: "ubiquinol-cytochrome c oxidoreductase complex (sensu Bacteria)" EXACT [] synonym: "ubiquinol-cytochrome-c reductase complex (sensu Bacteria)" EXACT [] xref: GO:0045276 xref: GO:0045286 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001936 ! respiratory chain complex III [Term] id: CCO:C0001938 name: respiratory chain complex IV namespace: cellular_component def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok synonym: "cytochrome c oxidase complex" EXACT [] xref: GO:0045277 xref: GO:0045287 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001939 name: plasma membrane respiratory chain complex IV namespace: cellular_component def: "A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "cytochrome c oxidase complex (sensu Bacteria)" EXACT [] synonym: "respiratory chain complex IV (sensu Bacteria)" EXACT [] xref: GO:0045278 xref: GO:0045288 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001938 ! respiratory chain complex IV [Term] id: CCO:C0001941 name: succinate dehydrogenase complex namespace: cellular_component def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701] subset: gosubset_prok xref: GO:0045281 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0001934 ! respiratory chain complex II [Term] id: CCO:C0001942 name: plasma membrane succinate dehydrogenase complex namespace: cellular_component def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701] subset: gosubset_prok synonym: "succinate dehydrogenase complex (sensu Bacteria)" EXACT [] xref: GO:0045282 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001941 ! succinate dehydrogenase complex relationship: part_of CCO:C0001935 ! plasma membrane respiratory chain complex II [Term] id: CCO:C0001943 name: fumarate reductase complex namespace: cellular_component def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:004224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224] comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. subset: gosubset_prok xref: GO:0045283 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0001934 ! respiratory chain complex II [Term] id: CCO:C0001944 name: plasma membrane fumarate reductase complex namespace: cellular_component def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:00224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224] comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. subset: gosubset_prok synonym: "fumarate reductase complex (sensu Bacteria)" EXACT [] xref: GO:0045284 is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001943 ! fumarate reductase complex relationship: part_of CCO:C0001935 ! plasma membrane respiratory chain complex II [Term] id: CCO:C0001945 name: mRNA editing complex namespace: cellular_component def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607] subset: goslim_pir synonym: "editosome" EXACT [] xref: GO:0045293 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0001946 name: tubulin complex namespace: cellular_component def: "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [http://cancerweb.ncl.ac.uk/, ISBN:0716731363] xref: GO:0045298 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000434 ! microtubule [Term] id: CCO:C0001947 name: chloroplast proton-transporting ATP synthase complex namespace: cellular_component def: "A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation." [GOC:mtg_sensu, GOC:pj, ISBN:0716743663] synonym: "chloroplast hydrogen-translocating F-type ATPase complex" EXACT [] synonym: "chloroplast proton-transporting F-type ATPase complex" EXACT [] synonym: "hydrogen-translocating F-type ATPase complex (sensu Viridiplantae)" EXACT [] xref: GO:0045320 is_a: CCO:C0001853 ! chloroplast part is_a: CCO:C0001855 ! thylakoid part is_a: CCO:C0001920 ! proton-transporting ATP synthase complex relationship: part_of CCO:C0000663 ! chloroplast thylakoid membrane [Term] id: CCO:C0001948 name: interleukin-1 receptor complex namespace: cellular_component def: "Complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075] xref: GO:0045323 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001949 name: clathrin-coated endocytic vesicle namespace: cellular_component def: "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators] xref: GO:0045334 is_a: CCO:C0000981 ! clathrin-coated vesicle is_a: CCO:C0000983 ! endocytic vesicle [Term] id: CCO:C0001950 name: phagocytic vesicle namespace: cellular_component def: "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "phagosome" EXACT [] xref: GO:0045335 is_a: CCO:C0000983 ! endocytic vesicle [Term] id: CCO:C0001951 name: clathrin-coated phagocytic vesicle namespace: cellular_component def: "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "clathrin-coated phagosome" EXACT [] xref: GO:0045336 is_a: CCO:C0001949 ! clathrin-coated endocytic vesicle is_a: CCO:C0001950 ! phagocytic vesicle [Term] id: CCO:C0001952 name: pole plasm namespace: cellular_component def: "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kva, http://cancerweb.ncl.ac.uk/] synonym: "germ plasm" NARROW [] synonym: "polar plasm" EXACT [] xref: GO:0045495 is_a: CCO:C0000324 ! cytoplasm [Term] id: CCO:C0001953 name: dosage compensation complex namespace: cellular_component def: "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kva, GOC:mah] subset: goslim_pir xref: GO:0046536 is_a: CCO:C0001840 ! extracellular region part is_a: CCO:C0001847 ! nuclear part relationship: part_of CCO:C0000130 ! sex chromosome [Term] id: CCO:C0001954 name: U4/U6 x U5 tri-snRNP complex namespace: cellular_component def: "A complex composed of three small nuclear ribonucleoproteins, snRNP U4, snRNP U6 and snRNP U5." [PMID:11867543] synonym: "U4/U6 . U5 snRNP complex" EXACT [] xref: GO:0046540 is_a: CCO:C0001022 ! small nuclear ribonucleoprotein complex [Term] id: CCO:C0001955 name: intercellular canaliculus namespace: cellular_component def: "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: GO:0046581 is_a: CCO:C0000463 ! intercellular junction [Term] id: CCO:C0001956 name: lysosomal proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] synonym: "lysosomal hydrogen ion-transporting ATPase V0 domain" EXACT [] xref: GO:0046610 is_a: CCO:C0000036 ! vacuolar proton-transporting V-type ATPase, V0 domain relationship: part_of CCO:C0001957 ! lysosomal proton-transporting V-type ATPase complex [Term] id: CCO:C0001957 name: lysosomal proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] synonym: "lysosomal hydrogen-translocating V-type ATPase complex" EXACT [] synonym: "lysosomal membrane hydrogen-transporting ATPase" BROAD [] xref: GO:0046611 is_a: CCO:C0000793 ! vacuolar proton-transporting V-type ATPase complex relationship: part_of CCO:C0000348 ! lysosomal membrane [Term] id: CCO:C0001958 name: lysosomal proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] synonym: "lysosomal hydrogen ion-transporting ATPase V1 domain" EXACT [] xref: GO:0046612 is_a: CCO:C0000037 ! vacuolar proton-transporting V-type ATPase, V1 domain relationship: part_of CCO:C0001957 ! lysosomal proton-transporting V-type ATPase complex [Term] id: CCO:C0001959 name: anchored to plasma membrane namespace: cellular_component def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah] synonym: "plasma membrane, GPI-anchored" NARROW [] xref: GO:0046658 is_a: CCO:C0001149 ! anchored to membrane is_a: CCO:C0001150 ! intrinsic to plasma membrane relationship: location_of CCO:B0001672 ! GAS1_HUMAN [Term] id: CCO:C0001960 name: intracellular canaliculus namespace: cellular_component def: "A narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:10700045] xref: GO:0046691 is_a: CCO:C0001877 ! plasma membrane part relationship: part_of CCO:C0000781 ! apical plasma membrane [Term] id: CCO:C0001961 name: SLIK (SAGA-like) complex namespace: cellular_component def: "A protein complex similar to the SAGA complex but with a smaller form of Spt7 and no Spt8. Although little is known about the SLIK complex, evidence suggests involvement of the general amino acid control pathway." [PMID:12101232, PMID:12186975] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "SAGA (alt) complex" EXACT [] synonym: "SALSA complex" EXACT [] synonym: "SLIK/SALSA complex" EXACT [] xref: GO:0046695 is_a: CCO:C0000011 ! histone acetyltransferase complex [Term] id: CCO:C0001962 name: lipopolysaccharide receptor complex namespace: cellular_component def: "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated." [PMID:11706042] comment: Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of. synonym: "LPS receptor complex" EXACT [] xref: GO:0046696 is_a: CCO:C0000767 ! integral to membrane is_a: CCO:C0001751 ! receptor complex relationship: location_of CCO:B0001458 ! BCL10_HUMAN [Term] id: CCO:C0001963 name: capsomere namespace: cellular_component def: "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "capsomer" EXACT [] xref: GO:0046727 is_a: CCO:C0001842 ! virion part relationship: part_of CCO:C0000867 ! viral capsid [Term] id: CCO:C0001964 name: viral procapsid namespace: cellular_component def: "A stable empty viral capsid produced during the assembly of viruses." [ISBN:0072370319, ISBN:1555811272] xref: GO:0046729 is_a: CCO:C0001842 ! virion part [Term] id: CCO:C0001965 name: viral portal complex namespace: cellular_component def: "A multimeric ring of proteins through which the DNA enters and exits the viral capsid." [PMID:11602732] xref: GO:0046798 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001842 ! virion part relationship: part_of CCO:C0000867 ! viral capsid [Term] id: CCO:C0001966 name: viral scaffold namespace: cellular_component def: "A complex of proteins that form a scaffold around which the viral capsid is constructed." [ISBN:0072370319] xref: GO:0046806 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001842 ! virion part relationship: part_of CCO:C0000867 ! viral capsid [Term] id: CCO:C0001967 name: assemblon namespace: cellular_component def: "Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously." [PMID:8676489] xref: GO:0046808 is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001968 name: replication compartment namespace: cellular_component def: "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously." [PMID:9499108] xref: GO:0046809 is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001969 name: virion transport vesicle namespace: cellular_component def: "A vesicle used to transport the partial or complete virion between cellular compartments." [PMID:7933124] xref: GO:0046816 is_a: CCO:C0001374 ! vesicle is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0001970 name: dense nuclear body namespace: cellular_component def: "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously." [PMID:10233976] xref: GO:0046818 is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0001971 name: extrachromosomal DNA namespace: cellular_component def: "DNA structures that are not part of a chromosome." [GOC:ai] subset: gosubset_prok xref: GO:0046821 is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001972 name: chlorosome namespace: cellular_component def: "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:14729689, PMID:15298919] subset: gosubset_prok xref: GO:0046858 is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001973 name: hydrogenosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a hydrogenosome." [GOC:ai] synonym: "hydrogenosome membrane" EXACT [] xref: GO:0046859 is_a: CCO:C0001127 ! organelle membrane is_a: CCO:C0001863 ! cytoplasmic part relationship: part_of CCO:C0001647 ! hydrogenosome [Term] id: CCO:C0001974 name: glycosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a glycosome." [GOC:ai] xref: GO:0046860 is_a: CCO:C0001127 ! organelle membrane relationship: part_of CCO:C0000914 ! glycosome [Term] id: CCO:C0001975 name: glyoxysomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a glyoxysome." [GOC:ai] synonym: "glyoxysome membrane" EXACT [] xref: GO:0046861 is_a: CCO:C0001341 ! microbody membrane is_a: CCO:C0001857 ! microbody part relationship: part_of CCO:C0000643 ! glyoxysome [Term] id: CCO:C0001976 name: chromoplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope." [GOC:ai, GOC:mah] xref: GO:0046862 is_a: CCO:C0001634 ! plastid membrane relationship: part_of CCO:C0001336 ! chromoplast envelope [Term] id: CCO:C0001977 name: mesosome namespace: cellular_component def: "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363986] subset: gosubset_prok xref: GO:0046868 is_a: CCO:C0001877 ! plasma membrane part [Term] id: CCO:C0001978 name: pore complex namespace: cellular_component def: "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "channel-forming toxin activity" RELATED [] synonym: "pore" EXACT [] synonym: "pore-forming toxin activity" RELATED [] xref: GO:0046930 is_a: CCO:C0000767 ! integral to membrane [Term] id: CCO:C0001979 name: apoplast namespace: cellular_component def: "The protoplasts of cells in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jic] xref: GO:0048046 is_a: CCO:C0000201 ! extracellular region [Term] id: CCO:C0001980 name: activin receptor complex namespace: cellular_component def: "Activin receptors can be type I or type II and are cell surface transmembrane receptors with serine/threonine activity." [GOC:jic, ISBN:0121551423] xref: GO:0048179 is_a: CCO:C0001751 ! receptor complex is_a: CCO:C0001877 ! plasma membrane part relationship: location_of CCO:B0035985 ! ACVR1_HUMAN-Phosphoserine501 relationship: part_of CCO:C0000445 ! integral to plasma membrane [Term] id: CCO:C0001981 name: activin complex namespace: cellular_component def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. subset: goslim_pir xref: GO:0048180 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001840 ! extracellular region part relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0001982 name: activin AB complex namespace: cellular_component def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. synonym: "inhibin beta-A" NARROW [] synonym: "inhibin beta-B" NARROW [] xref: GO:0048183 is_a: CCO:C0001981 ! activin complex [Term] id: CCO:C0001983 name: COMPASS complex namespace: cellular_component def: "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p." [PMID:11687631, PMID:11805083] synonym: "Set1 complex" NARROW [] synonym: "Set1C" NARROW [] xref: GO:0048188 is_a: CCO:C0000806 ! chromatin remodeling complex is_a: CCO:C0001616 ! histone methyltransferase complex [Term] id: CCO:C0001984 name: Lid2 complex namespace: cellular_component def: "A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p." [PMID:12488447] xref: GO:0048189 is_a: CCO:C0000806 ! chromatin remodeling complex [Term] id: CCO:C0001985 name: middle lamella-containing extracellular matrix namespace: cellular_component def: "The matrix external to the cell, composed of the cell wall and middle lamella." [GOC:jic, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk] comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell. subset: goslim_pir synonym: "extracellular matrix (sensu Magnoliophyta)" EXACT [] xref: GO:0048196 is_a: CCO:C0000999 ! external encapsulating structure is_a: CCO:C0001109 ! extracellular matrix [Term] id: CCO:C0001986 name: pectic matrix namespace: cellular_component def: "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls." [GOC:jic, http://cancerweb.ncl.ac.uk] xref: GO:0048217 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0000658 ! primary cell wall relationship: part_of CCO:C0000659 ! secondary cell wall [Term] id: CCO:C0001987 name: glycoprotein network namespace: cellular_component def: "A network of glycoproteins; proteins with covalently attached sugar units, either bonded via the hydroxyl group of serine or threonine (O glycosylated) or through the amino terminal of asparagine (N glycosylated)." [GOC:jic, http://cancerweb.ncl.ac.uk] subset: gosubset_prok synonym: "extensin" EXACT [] xref: GO:0048222 is_a: CCO:C0001839 ! extracellular matrix part is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0000658 ! primary cell wall [Term] id: CCO:C0001988 name: hemicellulose network namespace: cellular_component def: "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan." [GOC:jic, http://cancerweb.ncl.ac.uk] xref: GO:0048223 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0000658 ! primary cell wall relationship: part_of CCO:C0000659 ! secondary cell wall [Term] id: CCO:C0001989 name: lignin network namespace: cellular_component def: "A network composed of lignin; a complex polymer of phenylpropanoid subunits, laid down in the walls of plant cells such as xylem vessels and sclerenchyma. It imparts considerable strength to the wall and also protects it against degradation by microorganisms. It is also laid down as a defence reaction against pathogenic attack, as part of the hypersensitive response of plants." [GOC:jic, http://cancerweb.ncl.ac.uk] xref: GO:0048224 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0000659 ! secondary cell wall [Term] id: CCO:C0001990 name: suberin network namespace: cellular_component def: "Fatty substance, containing long chain fatty acids and fatty esters, found in the cell walls of cork cells (phellem) in higher plants. Renders the cell wall impervious to water." [GOC:jic, http://cancerweb.ncl.ac.uk] xref: GO:0048225 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0000659 ! secondary cell wall [Term] id: CCO:C0001991 name: Casparian strip namespace: cellular_component def: "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants." [GOC:jic, http://cancerweb.ncl.ac.uk] xref: GO:0048226 is_a: CCO:C0001845 ! cell wall part relationship: part_of CCO:C0000659 ! secondary cell wall [Term] id: CCO:C0001992 name: rough endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jic] synonym: "rough ER lumen" EXACT [] xref: GO:0048237 is_a: CCO:C0000369 ! endoplasmic reticulum lumen relationship: part_of CCO:C0000372 ! rough endoplasmic reticulum [Term] id: CCO:C0001993 name: smooth endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jic] synonym: "smooth ER lumen" EXACT [] xref: GO:0048238 is_a: CCO:C0000369 ! endoplasmic reticulum lumen relationship: part_of CCO:C0000371 ! smooth endoplasmic reticulum [Term] id: CCO:C0001994 name: methionine adenosyltransferase complex namespace: cellular_component def: "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules." [EC:2.5.1.6, GOC:jic, PMID:10644686] synonym: "MAT complex" EXACT [] xref: GO:0048269 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001995 name: primary endosperm nucleus namespace: cellular_component def: "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac." [ISBN:0471245208] xref: GO:0048353 is_a: CCO:C0000252 ! nucleus [Term] id: CCO:C0001996 name: perinuclear region of cytoplasm namespace: cellular_component def: "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jic] comment: Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'. xref: GO:0048471 is_a: CCO:C0001863 ! cytoplasmic part relationship: location_of CCO:B0001458 ! BCL10_HUMAN relationship: location_of CCO:B0001825 ! TPD53_HUMAN relationship: location_of CCO:B0031342 ! MYO16_HUMAN-Phosphotyrosine1432 [Term] id: CCO:C0001997 name: coated membrane namespace: cellular_component def: "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jic] xref: GO:0048475 is_a: CCO:C0000766 ! membrane [Term] id: CCO:C0001998 name: Holliday junction resolvase complex namespace: cellular_component def: "A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage." [PMID:11207366, PMID:12374758] subset: goslim_pir synonym: "Mus81-Eme1 complex" NARROW [] synonym: "resolvasome" EXACT [PMID:11207366] xref: GO:0048476 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0001999 name: ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg] subset: goslim_pir subset: gosubset_prok synonym: "RubisCO complex" EXACT [] xref: GO:0048492 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0002000 name: plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "plasma membrane ribulose bisphosphate carboxylase complex" EXACT [] synonym: "ribulose bisphosphate carboxylase complex (sensu Cyanobacteria)" EXACT [] synonym: "RubisCO complex (sensu Cyanobacteria)" EXACT [] xref: GO:0048493 is_a: CCO:C0001852 ! cytoplasmic vesicle part is_a: CCO:C0001855 ! thylakoid part is_a: CCO:C0001877 ! plasma membrane part is_a: CCO:C0001999 ! ribulose bisphosphate carboxylase complex relationship: part_of CCO:C0000942 ! plasma membrane-derived thylakoid [Term] id: CCO:C0002001 name: chromatophore ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "ribulose bisphosphate carboxylase complex (sensu Proteobacteria, Chloroflexaceae and Chlorobiaceae)" EXACT [] synonym: "RubisCO complex (sensu Proteobacteria)" EXACT [] xref: GO:0048494 is_a: CCO:C0001688 ! chromatophore is_a: CCO:C0001999 ! ribulose bisphosphate carboxylase complex [Term] id: CCO:C0002002 name: signal recognition particle namespace: cellular_component def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg] subset: goslim_pir subset: gosubset_prok xref: GO:0048500 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0002003 name: signal recognition particle, plasma membrane targeting namespace: cellular_component def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "signal recognition particle (sensu Bacteria and Archaea)" EXACT [] xref: GO:0048501 is_a: CCO:C0002002 ! signal recognition particle [Term] id: CCO:C0002004 name: generative cell nucleus namespace: cellular_component def: "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells." [GOC:tair_curators] synonym: "male germ cell nucleus (sensu Magnoliophyta)" EXACT [] synonym: "sperm cell nucleus (sensu Magnoliophyta)" RELATED [] xref: GO:0048555 is_a: CCO:C0000252 ! nucleus [Term] id: CCO:C0002005 name: microsporocyte nucleus namespace: cellular_component def: "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte." [GOC:tair_curators, ISBN:047186840X] synonym: "microspore mother cell nucleus" EXACT [] synonym: "pollen mother cell nucleus" EXACT [] xref: GO:0043074 xref: GO:0048556 is_a: CCO:C0000252 ! nucleus [Term] id: CCO:C0002006 name: pigment granule namespace: cellular_component def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jic, GOC:mh] xref: GO:0048770 is_a: CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0002007 name: presynaptic active zone namespace: cellular_component def: "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jic, PMID:3152289] xref: GO:0048786 is_a: CCO:C0001875 ! synapse part is_a: CCO:C0002130 ! intracellular non-membrane-bounded organelle [Term] id: CCO:C0002008 name: presynaptic active zone membrane namespace: cellular_component def: "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289] synonym: "active zone presynaptic plasma membrane" EXACT [] xref: GO:0048787 is_a: CCO:C0001695 ! presynaptic membrane relationship: part_of CCO:C0002007 ! presynaptic active zone [Term] id: CCO:C0002009 name: presynaptic cytoskeletal matrix assembled at active zones namespace: cellular_component def: "The specialized cytoskeletal matrix assembled at the active zones of the presynaptic nerve terminal. The cytoskeletal matrix is a proteinaceous structure involved in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. The cytomatrix protein exclusively assembled at active zones, is thought to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jic, PMID:10944438] synonym: "CAZ" NARROW [] synonym: "presynaptic cytomatrix assembled at active zones" EXACT [] xref: GO:0048788 is_a: CCO:C0001055 ! cortical cytoskeleton is_a: CCO:C0001875 ! synapse part relationship: part_of CCO:C0002007 ! presynaptic active zone [Term] id: CCO:C0002010 name: secondary cell septum namespace: cellular_component def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814] synonym: "secondary cell septum (sensu Fungi)" EXACT [] synonym: "secondary septum (sensu Fungi)" EXACT [] xref: GO:0051077 is_a: CCO:C0001008 ! cell septum [Term] id: CCO:C0002011 name: spindle midzone namespace: cellular_component def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] synonym: "spindle equator" EXACT [] xref: GO:0051233 is_a: CCO:C0001849 ! cytoskeletal part relationship: part_of CCO:C0000388 ! spindle [Term] id: CCO:C0002012 name: cell cortex of cell tip namespace: cellular_component def: "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai] synonym: "cell cortex of cell end" EXACT [] xref: GO:0051285 is_a: CCO:C0001867 ! cell cortex part relationship: part_of CCO:C0002013 ! cell tip [Term] id: CCO:C0002013 name: cell tip namespace: cellular_component def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth may occur." [GOC:ai, GOC:vw] synonym: "cell end" EXACT [] xref: GO:0051286 is_a: CCO:C0001007 ! site of polarized growth [Term] id: CCO:C0002014 name: cortical microtubule namespace: cellular_component def: "Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol." [GOC:mtg_sensu] xref: GO:0055028 is_a: CCO:C0000434 ! microtubule relationship: part_of CCO:C0001096 ! cortical microtubule cytoskeleton [Term] id: CCO:C0002015 name: nuclear DNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] xref: GO:0055029 is_a: CCO:C0000085 ! DNA-directed RNA polymerase complex [Term] id: CCO:C0002016 name: peptidoglycan-based spore wall namespace: cellular_component def: "A spore wall consisting of a peptidoglycan-containing inner layer (the spore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:mtg_sensu, PMID:15035041] synonym: "spore wall (sensu Bacteria)" EXACT [] xref: GO:0055030 is_a: CCO:C0001137 ! spore wall [Term] id: CCO:C0002017 name: gamma-tubulin large complex, equatorial microtubule organizing center namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at equatorial microtubule organizing centers." [GOC:mtg_sensu] synonym: "gamma-tubulin large complex, eMTOC" EXACT [] synonym: "gamma-tubulin large complex, equatorial microtubule organizing centre" EXACT [] xref: GO:0055031 is_a: CCO:C0000150 ! gamma-tubulin large complex relationship: part_of CCO:C0000145 ! equatorial microtubule organizing center [Term] id: CCO:C0002018 name: gamma-tubulin large complex, spindle pole body namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the spindle pole body." [GOC:mtg_sensu] xref: GO:0055032 is_a: CCO:C0000150 ! gamma-tubulin large complex relationship: part_of CCO:C0000386 ! spindle pole body [Term] id: CCO:C0002019 name: gamma-tubulin large complex, interphase microtubule organizing center namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at interphase microtubule organizing centers." [GOC:mtg_sensu] synonym: "gamma-tubulin large complex, iMTOC" EXACT [] synonym: "gamma-tubulin large complex, interphase microtubule organizing centre" EXACT [] xref: GO:0055033 is_a: CCO:C0000150 ! gamma-tubulin large complex relationship: part_of CCO:C0001113 ! interphase microtubule organizing center [Term] id: CCO:C0002020 name: plastid thylakoid membrane namespace: cellular_component def: "The lipid bilayer membrane of any thylakoid within a plastid." [GOC:jic, GOC:rph] xref: GO:0055035 is_a: CCO:C0001684 ! thylakoid membrane is_a: CCO:C0001854 ! plastid part relationship: part_of CCO:C0001368 ! plastid thylakoid [Term] id: CCO:C0002021 name: virion membrane namespace: cellular_component def: "The lipid bilayer surrounding a virion." [GOC:jic, GOC:rph, PMID:213106] xref: GO:0055036 is_a: CCO:C0001842 ! virion part [Term] id: CCO:C0002022 name: recycling endosome namespace: cellular_component def: "Organelle consisting of networks of 60nm tubules organized around the microtubule organizing centre in some cell types. They transport receptors from late endosomes back to the plasma membrane for recycling and are also involved in membrane trafficking." [GOC:jic, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] xref: GO:0055037 is_a: CCO:C0000351 ! endosome [Term] id: CCO:C0002023 name: recycling endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a recycling endosome." [GOC:jic, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] xref: GO:0055038 is_a: CCO:C0000713 ! endosome membrane is_a: CCO:C0002022 ! recycling endosome [Term] id: CCO:C0002024 name: trichocyst namespace: cellular_component def: "A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in \"nets\" to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft." [GOC:jic, GOC:rph, http://www.iscid.org/encyclopedia/, PMID:3667715] xref: GO:0055039 is_a: CCO:C0002131 ! extracellular non-membrane-bounded organelle [Term] id: CCO:C0002025 name: periplasmic flagellum namespace: cellular_component def: "Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella." [GOC:jic, GOC:rph, PMID:15175283, PMID:1624463] xref: GO:0055040 is_a: CCO:C0000561 ! flagellin-based flagellum relationship: part_of CCO:C0001662 ! periplasmic space [Term] id: CCO:C0002026 name: symplast namespace: cellular_component def: "The interconnected protoplasts of a plant. The interconnections occur via the plasmodesmata." [GOC:mtg_sensu] subset: goslim_pir xref: GO:0055044 is_a: CCO:C0000200 ! cellular_component [Term] id: CCO:C0002027 name: ATP-binding cassette (ABC) transporter complex, integrated substrate binding namespace: cellular_component def: "A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a \"half transporter\". Two \"half-transporters\" come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] xref: GO:0055051 is_a: CCO:C0001725 ! ATP-binding cassette (ABC) transporter complex [Term] id: CCO:C0002028 name: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing namespace: cellular_component def: "A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] xref: GO:0055052 is_a: CCO:C0001725 ! ATP-binding cassette (ABC) transporter complex [Term] id: CCO:C0002029 name: Ski complex namespace: cellular_component def: "A heterotrimeric protein complex that regulates RNA degradation by the exosome complex." [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509] xref: GO:0055087 is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0002030 name: neurofilament cytoskeleton namespace: cellular_component def: "Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons." [GOC:dph] xref: GO:0060053 is_a: CCO:C0001888 ! intermediate filament cytoskeleton [Term] id: CCO:C0002031 name: excitatory synapse namespace: cellular_component def: "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] xref: GO:0060076 is_a: CCO:C0001900 ! synapse [Term] id: CCO:C0002032 name: inhibitory synapse namespace: cellular_component def: "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] xref: GO:0060077 is_a: CCO:C0001900 ! synapse [Term] id: CCO:C0002033 name: kinocilium namespace: cellular_component def: "An immotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia." [GOC:dph, PMID:15882574] xref: GO:0060091 is_a: CCO:C0001281 ! nonmotile primary cilium relationship: part_of CCO:C0001447 ! stereocilium bundle [Term] id: CCO:C0002034 name: collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection." [GOC:dph, GOC:kva, ISSN:15518507] synonym: "collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] synonym: "collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] xref: GO:0060102 is_a: CCO:C0000203 ! proteinaceous extracellular matrix [Term] id: CCO:C0002035 name: collagen and cuticulin-based cuticle extracellular matrix part namespace: cellular_component def: "Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer." [GOC:dph] xref: GO:0060103 is_a: CCO:C0001839 ! extracellular matrix part [Term] id: CCO:C0002036 name: surface coat of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion." [GOC:dph, GOC:kva, ISSN:15518507] synonym: "surface coat of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] synonym: "surface coat of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] xref: GO:0060104 is_a: CCO:C0002035 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of CCO:C0002034 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: CCO:C0002037 name: epicuticle of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat." [GOC:dph, GOC:kva, ISSN:15518507] synonym: "epicuticle of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] synonym: "epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] xref: GO:0060105 is_a: CCO:C0002035 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of CCO:C0002034 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: CCO:C0002038 name: cortical layer of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows." [GOC:dph, GOC:kva, ISSN:15518507] synonym: "cortical layer of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] synonym: "cortical layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] xref: GO:0060106 is_a: CCO:C0002035 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of CCO:C0002034 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: CCO:C0002039 name: annuli extracellular matrix namespace: cellular_component def: "The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present." [GOC:dph, GOC:kva, ISSN:15518507] synonym: "annulae" RELATED [] synonym: "annular rings" RELATED [] synonym: "annule(s)" RELATED [] synonym: "annulus" RELATED [] xref: GO:0060107 is_a: CCO:C0002035 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of CCO:C0002038 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix [Term] id: CCO:C0002040 name: annular furrow extracellular matrix namespace: cellular_component def: "The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline." [GOC:dph, GOC:kva, ISSN:15518507] xref: GO:0060108 is_a: CCO:C0002035 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of CCO:C0002038 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix [Term] id: CCO:C0002041 name: medial layer of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals." [GOC:dph, GOC:kva, ISSN:15518507] synonym: "medial layer struts" RELATED [] xref: GO:0060109 is_a: CCO:C0002035 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of CCO:C0002034 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: CCO:C0002042 name: basal layer of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae." [GOC:dph, GOC:kva, ISSN:15518507] synonym: "basal layer of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] synonym: "basal layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] xref: GO:0060110 is_a: CCO:C0002035 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of CCO:C0002034 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: CCO:C0002043 name: alae of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively." [GOC:dph, GOC:kva, ISSN:15518507] synonym: "alae of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] synonym: "alae of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] xref: GO:0060111 is_a: CCO:C0002035 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of CCO:C0002034 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: CCO:C0002044 name: cilium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cilium." [GOC:dph, GOC:rh] xref: GO:0060170 is_a: CCO:C0001173 ! cell projection membrane is_a: CCO:C0001860 ! cilium part [Term] id: CCO:C0002045 name: stereocilium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a stereocilium." [GOC:dph, GOC:rh] xref: GO:0060171 is_a: CCO:C0001292 ! microvillus membrane relationship: part_of CCO:C0001446 ! stereocilium [Term] id: CCO:C0002047 name: stress granule namespace: cellular_component def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [PMID:17601829] xref: GO:0010494 is_a: CCO:C0001019 ! ribonucleoprotein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0002048 name: exomer complex namespace: cellular_component def: "A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues." [PMID:16498409, PMID:17000877] xref: GO:0034044 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000984 ! trans-Golgi network transport vesicle [Term] id: CCO:C0002049 name: pre-autophagosomal structure membrane namespace: cellular_component def: "A cellular membrane associated with the pre-autophagosomal structure." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324] synonym: "isolation membrane" RELATED [] synonym: "PAS membrane" EXACT [] xref: GO:0034045 is_a: CCO:C0000766 ! membrane relationship: part_of CCO:C0000077 ! pre-autophagosomal structure [Term] id: CCO:C0002050 name: cell pole namespace: cellular_component def: "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph] xref: GO:0060187 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0002051 name: flagellin-based flagellum filament namespace: cellular_component def: "The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar filament" EXACT [] synonym: "flagellar filament (sensu Bacteria)" EXACT [] xref: GO:0009420 is_a: CCO:C0001879 ! flagellin-based flagellum part [Term] id: CCO:C0002052 name: flagellin-based flagellum filament cap namespace: cellular_component def: "The proteinaceous structure at the distal tip of the flagellar filament." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar filament cap" EXACT [] synonym: "flagellar filament cap (sensu Bacteria)" EXACT [] xref: GO:0009421 is_a: CCO:C0001879 ! flagellin-based flagellum part relationship: part_of CCO:C0002051 ! flagellin-based flagellum filament [Term] id: CCO:C0002053 name: flagellin-based flagellum hook-filament junction namespace: cellular_component def: "The region of the flagellum where the hook and filament meet." [GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar hook-filament junction" EXACT [] synonym: "flagellar hook-filament junction (sensu Bacteria)" EXACT [] xref: GO:0009422 is_a: CCO:C0001879 ! flagellin-based flagellum part [Term] id: CCO:C0002054 name: flagellin-based flagellum hook namespace: cellular_component def: "The portion of the flagellum that connects the filament to the basal body." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar hook" EXACT [] synonym: "flagellar hook (sensu Bacteria)" EXACT [] xref: GO:0009424 is_a: CCO:C0001879 ! flagellin-based flagellum part [Term] id: CCO:C0002055 name: flagellin-based flagellum basal body, distal rod namespace: cellular_component def: "The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, distal rod" EXACT [] synonym: "flagellar basal body, distal rod (sensu Bacteria)" EXACT [] xref: GO:0009426 is_a: CCO:C0001879 ! flagellin-based flagellum part relationship: part_of CCO:C0002062 ! flagellin-based flagellum basal body, rod [Term] id: CCO:C0002056 name: flagellin-based flagellum basal body, distal rod, L ring namespace: cellular_component def: "One of the rings of the flagellar basal body; anchors the basal body to the outer membrane." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, distal rod, L ring" EXACT [] synonym: "flagellar basal body, distal rod, L ring (sensu Bacteria)" EXACT [] xref: GO:0009427 is_a: CCO:C0001879 ! flagellin-based flagellum part relationship: part_of CCO:C0002055 ! flagellin-based flagellum basal body, distal rod [Term] id: CCO:C0002057 name: flagellin-based flagellum basal body, distal rod, P ring namespace: cellular_component def: "One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, distal rod, P ring" RELATED [] synonym: "flagellar basal body, distal rod, P ring (sensu Bacteria)" EXACT [] xref: GO:0009428 is_a: CCO:C0001879 ! flagellin-based flagellum part relationship: part_of CCO:C0002055 ! flagellin-based flagellum basal body, distal rod [Term] id: CCO:C0002058 name: flagellin-based flagellum basal body, proximal rod namespace: cellular_component def: "The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, proximal rod" EXACT [] synonym: "flagellar basal body, proximal rod (sensu Bacteria)" EXACT [] xref: GO:0009429 is_a: CCO:C0001879 ! flagellin-based flagellum part relationship: part_of CCO:C0002062 ! flagellin-based flagellum basal body, rod [Term] id: CCO:C0002059 name: flagellin-based flagellum basal body, MS ring namespace: cellular_component def: "One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, mounting plate (sensu Bacteria)" EXACT [] synonym: "flagellar basal body, MS ring" EXACT [] synonym: "flagellar basal body, MS ring (sensu Bacteria)" EXACT [] xref: GO:0009430 xref: GO:0009431 is_a: CCO:C0001879 ! flagellin-based flagellum part relationship: part_of CCO:C0000622 ! flagellin-based flagellum basal body [Term] id: CCO:C0002060 name: flagellin-based flagellum basal body, C ring namespace: cellular_component def: "Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, C ring" EXACT [] synonym: "flagellar basal body, C ring (sensu Bacteria)" EXACT [] xref: GO:0009433 is_a: CCO:C0001879 ! flagellin-based flagellum part relationship: part_of CCO:C0000622 ! flagellin-based flagellum basal body [Term] id: CCO:C0002061 name: plastoglobuli namespace: cellular_component def: "Lipid bodies localized within the chloroplast stroma." [PMID:17259290] xref: GO:0010502 is_a: CCO:C0001853 ! chloroplast part relationship: part_of CCO:C0000681 ! chloroplast stroma [Term] id: CCO:C0002062 name: flagellin-based flagellum basal body, rod namespace: cellular_component def: "The central portion of the flagellar basal body, which spans the periplasm and threads through the rings." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, rod" EXACT [] synonym: "flagellar basal body, rod (sensu Bacteria)" EXACT [] xref: GO:0030694 is_a: CCO:C0001879 ! flagellin-based flagellum part relationship: part_of CCO:C0000622 ! flagellin-based flagellum basal body [Term] id: CCO:C0002063 name: NADH dehydrogenase complex namespace: cellular_component def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyses the transfer of a pair of electrons from NADH to a quinone." [GOC:mah] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'. subset: goslim_pir subset: gosubset_prok synonym: "Complex I" EXACT [] synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW [] synonym: "NADH dehydrogenase complex (plastoquinone) (sensu Cyanobacteria)" NARROW [] synonym: "NADH dehydrogenase complex (quinone) (sensu Bacteria)" NARROW [] synonym: "NADH dehydrogenase complex (ubiquinone) (sensu Bacteria)" NARROW [] synonym: "NADH:plastoquinone reductase complex" NARROW [] synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW [] xref: GO:0030025 xref: GO:0030964 xref: GO:0030966 xref: GO:0031675 xref: GO:0031677 xref: GO:0031678 xref: GO:0045280 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part is_a: CCO:C0001844 ! membrane part [Term] id: CCO:C0002064 name: acidocalcisome lumen namespace: cellular_component def: "The volume enclosed by the membranes of an acidocalcisome." [GOC:mah] xref: GO:0033985 is_a: CCO:C0001749 ! organelle lumen relationship: part_of CCO:C0000919 ! acidocalcisome [Term] id: CCO:C0002065 name: fungal-type spore wall namespace: cellular_component def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division." [GOC:vw, ISBN:0879693568] synonym: "spore wall (sensu Fungi)" EXACT [] xref: GO:0005619 is_a: CCO:C0001137 ! spore wall [Term] id: CCO:C0002066 name: fungal-type cell wall namespace: cellular_component def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu_feb07, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422] synonym: "beta-glucan-containing cell wall" RELATED [] synonym: "cell wall (sensu Fungi)" EXACT [] synonym: "chitin- and beta-glucan-containing cell wall" NARROW [] synonym: "chitin-containing cell wall" RELATED [] xref: GO:0009277 is_a: CCO:C0000239 ! cell wall [Term] id: CCO:C0002067 name: TORC1 complex namespace: cellular_component def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy." [GOC:jh, PMID:15780592] synonym: "nutrient sensitive complex" EXACT [] synonym: "TOR complex 1" EXACT [] synonym: "TORC 1 complex" EXACT [] xref: GO:0031931 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0002068 name: TORC2 complex namespace: cellular_component def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates spatial control of cell growth via regulation of actin cytoskeleton polarization." [GOC:jh, PMID:15780592] synonym: "TORC 2 complex" EXACT [] xref: GO:0031932 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part [Term] id: CCO:C0002069 name: cyanelle stroma namespace: cellular_component def: "The space enclosed by the double membrane of a cyanelle." [GOC:rph] xref: GO:0034060 is_a: CCO:C0000660 ! plastid stroma relationship: part_of CCO:C0000700 ! cyanelle [Term] id: CCO:C0002070 name: Tor2-Mei2-Ste11 complex namespace: cellular_component def: "A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast." [GOC:vw, PMID:17046992] xref: GO:0034064 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0002072 name: Ric1p-Rgp1p complex namespace: cellular_component def: "A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi." [GOC:jh, GOC:mah, PMID:10990452] xref: GO:0034066 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001850 ! Golgi apparatus part [Term] id: CCO:C0002073 name: polyketide synthase complex namespace: cellular_component def: "A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones." [GOC:mah, PMID:12636085] synonym: "PKS" RELATED [] synonym: "PKS complex" EXACT [] xref: GO:0034081 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0002074 name: type II polyketide synthase complex namespace: cellular_component def: "A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction." [GOC:cb, GOC:mah, PMID:12636085] synonym: "type II PKS" EXACT [] synonym: "type II PKS complex" EXACT [] synonym: "type II polyketide synthase" EXACT [] xref: GO:0034082 is_a: CCO:C0002073 ! polyketide synthase complex [Term] id: CCO:C0002075 name: type III polyketide synthase complex namespace: cellular_component def: "A polyketide synthase complex that consists of two identical ketosynthase polypeptides." [GOC:cb, PMID:12636085] synonym: "type III PKS" EXACT [] synonym: "type III PKS complex" EXACT [] synonym: "type III polyketide synthase" EXACT [] xref: GO:0034083 is_a: CCO:C0002073 ! polyketide synthase complex [Term] id: CCO:C0002076 name: Cdc48p-Npl4p-Ufd1p AAA ATPase complex namespace: cellular_component def: "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins." [PMID:11813000, PMID:16179952] xref: GO:0034098 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0002077 name: luminal surveillance complex namespace: cellular_component def: "A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins." [PMID:16873065] xref: GO:0034099 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000369 ! endoplasmic reticulum lumen [Term] id: CCO:C0002078 name: proteasome complex namespace: cellular_component def: "A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb] subset: goslim_pir synonym: "26S proteasome" NARROW [] synonym: "proteasome complex (sensu Eukaryota)" EXACT [] xref: GO:0000502 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: location_of CCO:B0001625 ! PSMD8_HUMAN relationship: location_of CCO:B0006215 ! PSME1_HUMAN relationship: location_of CCO:B0013617 ! PRS4_HUMAN-Phosphotyrosine439 relationship: location_of CCO:B0013618 ! PSA1_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0021560 ! PSMD3_HUMAN relationship: location_of CCO:B0023606 ! PSDE_HUMAN relationship: location_of CCO:B0030800 ! PSB2_HUMAN relationship: location_of CCO:B0032651 ! PSMD6_HUMAN relationship: location_of CCO:B0034007 ! PSB7_HUMAN relationship: location_of CCO:B0035474 ! PSA5_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0035478 ! PSB1_HUMAN-Phosphotyrosine150 relationship: location_of CCO:B0039597 ! PRS10_HUMAN-N-acetylalanine2 relationship: location_of CCO:B0041246 ! PRS7_HUMAN relationship: location_of CCO:B0041255 ! PSMD5_HUMAN relationship: location_of CCO:B0041324 ! PSA4_HUMAN-Phosphoserine13 relationship: location_of CCO:B0041328 ! PSD10_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0041333 ! PSMD4_HUMAN-Phosphoserine358 [Term] id: CCO:C0002079 name: proteasome regulatory particle namespace: cellular_component def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:proteasome, GOC:rb] synonym: "19S regulatory particle" NARROW [] synonym: "PA700 proteasome activator" NARROW [] synonym: "proteasome regulatory particle (sensu Eukaryota)" EXACT [] xref: GO:0005838 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: location_of CCO:B0001625 ! PSMD8_HUMAN relationship: location_of CCO:B0041328 ! PSD10_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0041336 ! PSMD9_HUMAN-Phosphoserine129 relationship: part_of CCO:C0002086 ! proteasome accessory complex [Term] id: CCO:C0002080 name: proteasome core complex namespace: cellular_component def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] synonym: "20S core complex" NARROW [] synonym: "26S proteasome" NARROW [] synonym: "macropain" EXACT [] synonym: "proteasome core complex (sensu Bacteria)" EXACT [] synonym: "proteasome core complex (sensu Eukaryota)" EXACT [] xref: GO:0000503 xref: GO:0005839 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001864 ! cytosolic part relationship: location_of CCO:B0013618 ! PSA1_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0030800 ! PSB2_HUMAN relationship: location_of CCO:B0034007 ! PSB7_HUMAN relationship: location_of CCO:B0035474 ! PSA5_HUMAN-N-acetylmethionine1 relationship: location_of CCO:B0035478 ! PSB1_HUMAN-Phosphotyrosine150 relationship: location_of CCO:B0041324 ! PSA4_HUMAN-Phosphoserine13 relationship: part_of CCO:C0002078 ! proteasome complex [Term] id: CCO:C0002081 name: proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:proteasome, GOC:rb] synonym: "proteasome regulatory particle, base subcomplex (sensu Eukaryota)" EXACT [] xref: GO:0008540 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0002079 ! proteasome regulatory particle [Term] id: CCO:C0002082 name: proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] synonym: "proteasome regulatory particle, lid subcomplex (sensu Eukaryota)" EXACT [] xref: GO:0008541 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0002079 ! proteasome regulatory particle [Term] id: CCO:C0002083 name: proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex." [GOC:jl, GOC:mtg_sensu, GOC:proteasome, GOC:rb, PMID:10854779] synonym: "proteasome core complex, alpha-subunit complex (sensu Eukaryota)" EXACT [] xref: GO:0019773 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0002080 ! proteasome core complex [Term] id: CCO:C0002084 name: proteasome core complex, beta-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex." [GOC:jl, GOC:mtg_sensu, GOC:proteasome, GOC:rb, PMID:10854779] synonym: "proteasome core complex, beta-subunit complex (sensu Eukaryota)" EXACT [] xref: GO:0019774 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001843 ! intracellular part relationship: part_of CCO:C0002080 ! proteasome core complex [Term] id: CCO:C0002085 name: proteasome-activating nucleotidase complex namespace: cellular_component def: "A multisubunit complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:mtg_sensu, GOC:proteasome] synonym: "PAN" EXACT [] xref: GO:0022623 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0002086 ! proteasome accessory complex [Term] id: CCO:C0002086 name: proteasome accessory complex namespace: cellular_component def: "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu, GOC:proteasome] xref: GO:0022624 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0002078 ! proteasome complex [Term] id: CCO:C0002087 name: cytosolic large ribosomal subunit namespace: cellular_component def: "The large subunit of the ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:mtg_sensu] synonym: "50S ribosomal subunit" NARROW [] synonym: "60S ribosomal subunit" NARROW [] synonym: "cytosolic large ribosomal subunit (sensu Archaea)" NARROW [] synonym: "cytosolic large ribosomal subunit (sensu Bacteria)" NARROW [] synonym: "cytosolic large ribosomal subunit (sensu Eukaryota)" NARROW [] synonym: "eukaryotic ribosomal LSU" NARROW [] synonym: "prokaryotic large ribosomal subunit" NARROW [] xref: GO:0005842 xref: GO:0009282 xref: GO:0022625 xref: GO:0030498 xref: GO:0030872 is_a: CCO:C0000755 ! large ribosomal subunit is_a: CCO:C0001864 ! cytosolic part relationship: part_of CCO:C0002088 ! cytosolic ribosome [Term] id: CCO:C0002088 name: cytosolic ribosome namespace: cellular_component def: "A ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:mtg_sensu] synonym: "70S ribosome" NARROW [] synonym: "80S ribosome" NARROW [] synonym: "cytosolic ribosome (sensu Archaea)" NARROW [] synonym: "cytosolic ribosome (sensu Bacteria)" NARROW [] synonym: "cytosolic ribosome (sensu Eukaryota)" NARROW [] xref: GO:0005830 xref: GO:0009281 xref: GO:0022626 xref: GO:0030871 is_a: CCO:C0000407 ! ribosome is_a: CCO:C0001864 ! cytosolic part [Term] id: CCO:C0002089 name: cytosolic small ribosomal subunit namespace: cellular_component def: "The small subunit of the ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:mtg_sensu] synonym: "30S ribosomal subunit" NARROW [] synonym: "40S ribosomal subunit" NARROW [] synonym: "cytosolic small ribosomal subunit (sensu Archaea)" NARROW [] synonym: "cytosolic small ribosomal subunit (sensu Bacteria)" NARROW [] synonym: "cytosolic small ribosomal subunit (sensu Eukaryota)" NARROW [] synonym: "eukaryotic ribosomal SSU" NARROW [] synonym: "prokaryotic small ribosomal subunit" NARROW [] xref: GO:0005843 xref: GO:0009283 xref: GO:0022627 xref: GO:0030499 xref: GO:0030873 is_a: CCO:C0000756 ! small ribosomal subunit is_a: CCO:C0001864 ! cytosolic part relationship: part_of CCO:C0002088 ! cytosolic ribosome [Term] id: CCO:C0002090 name: chloroplast large ribosomal subunit namespace: cellular_component def: "The large subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] xref: GO:0022628 is_a: CCO:C0000055 ! plastid large ribosomal subunit relationship: part_of CCO:C0001755 ! chloroplast ribosome [Term] id: CCO:C0002091 name: chloroplast small ribosomal subunit namespace: cellular_component def: "The small subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] xref: GO:0022629 is_a: CCO:C0000056 ! plastid small ribosomal subunit relationship: part_of CCO:C0001755 ! chloroplast ribosome [Term] id: CCO:C0002092 name: cytosolic proteasome complex namespace: cellular_component def: "A proteasome complex found in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] synonym: "cytosolic proteasome complex (sensu Eukaryota)" EXACT [] xref: GO:0031597 is_a: CCO:C0001864 ! cytosolic part is_a: CCO:C0002078 ! proteasome complex [Term] id: CCO:C0002093 name: cytosolic proteasome regulatory particle namespace: cellular_component def: "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] synonym: "cytosolic proteasome regulatory particle (sensu Eukaryota)" EXACT [] xref: GO:0031600 is_a: CCO:C0001864 ! cytosolic part is_a: CCO:C0002079 ! proteasome regulatory particle relationship: part_of CCO:C0002092 ! cytosolic proteasome complex [Term] id: CCO:C0002094 name: cytosolic proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] synonym: "cytosolic proteasome core complex (sensu Eukaryota)" EXACT [] xref: GO:0031603 is_a: CCO:C0002080 ! proteasome core complex relationship: part_of CCO:C0002092 ! cytosolic proteasome complex [Term] id: CCO:C0002095 name: cytosolic proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] synonym: "cytosolic proteasome core complex, alpha-subunit complex (sensu Eukaryota)" EXACT [] xref: GO:0031606 is_a: CCO:C0001864 ! cytosolic part is_a: CCO:C0002083 ! proteasome core complex, alpha-subunit complex relationship: part_of CCO:C0002094 ! cytosolic proteasome core complex [Term] id: CCO:C0002096 name: cytosolic proteasome core complex, beta-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] synonym: "cytosolic proteasome core complex, beta-subunit complex (sensu Eukaryota)" EXACT [] xref: GO:0031609 is_a: CCO:C0001864 ! cytosolic part is_a: CCO:C0002084 ! proteasome core complex, beta-subunit complex relationship: part_of CCO:C0002094 ! cytosolic proteasome core complex [Term] id: CCO:C0002097 name: cytosolic proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] synonym: "cytosolic proteasome regulatory particle, base subcomplex (sensu Eukaryota)" EXACT [] xref: GO:0031612 is_a: CCO:C0001864 ! cytosolic part is_a: CCO:C0002081 ! proteasome regulatory particle, base subcomplex relationship: part_of CCO:C0002093 ! cytosolic proteasome regulatory particle [Term] id: CCO:C0002098 name: cytosolic proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] synonym: "cytosolic proteasome regulatory particle, lid subcomplex (sensu Eukaryota)" EXACT [] xref: GO:0031615 is_a: CCO:C0001864 ! cytosolic part is_a: CCO:C0002082 ! proteasome regulatory particle, lid subcomplex relationship: part_of CCO:C0002093 ! cytosolic proteasome regulatory particle [Term] id: CCO:C0002099 name: enhanceosome namespace: cellular_component def: "A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation." [PMID:11250145, PMID:17574024] xref: GO:0034206 is_a: CCO:C0001494 ! protein-DNA complex [Term] id: CCO:C0002100 name: ER ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the ER." [GOC:elh] xref: GO:0000835 is_a: CCO:C0000026 ! ubiquitin ligase complex relationship: part_of CCO:C0000370 ! endoplasmic reticulum membrane [Term] id: CCO:C0002101 name: Hrd1p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] xref: GO:0000836 is_a: CCO:C0002100 ! ER ubiquitin ligase complex [Term] id: CCO:C0002102 name: Doa10p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066] synonym: "Ssm4p ubiquitin ligase complex" EXACT [] xref: GO:0000837 is_a: CCO:C0002100 ! ER ubiquitin ligase complex [Term] id: CCO:C0002103 name: Hrd1p ubiquitin ligase ERAD-M complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] xref: GO:0000838 is_a: CCO:C0002101 ! Hrd1p ubiquitin ligase complex [Term] id: CCO:C0002104 name: Hrd1p ubiquitin ligase ERAD-L complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066] xref: GO:0000839 is_a: CCO:C0002101 ! Hrd1p ubiquitin ligase complex [Term] id: CCO:C0002105 name: cyclic-nucleotide phosphodiesterase complex namespace: cellular_component def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW [] xref: GO:0005966 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0002106 name: mitochondrial DNA-directed RNA polymerase complex namespace: cellular_component def: "A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form." [GOC:krc, GOC:mah, PMID:7929382] synonym: "mitochondrial RNA polymerase complex" BROAD [] synonym: "mitochondrial RNA polymerase holoenzyme complex" EXACT [] xref: GO:0034245 is_a: CCO:C0000085 ! DNA-directed RNA polymerase complex is_a: CCO:C0001848 ! mitochondrial part [Term] id: CCO:C0002107 name: clathrin sculpted vesicle namespace: cellular_component def: "A clathrin sculpted lipid bilayer membrane enclosed vesicle after clathrin release." [GOC:dph] xref: GO:0060198 is_a: CCO:C0000981 ! clathrin-coated vesicle [Term] id: CCO:C0002108 name: clathrin sculpted glutamate transport vesicle namespace: cellular_component def: "A clathrin sculpted lipid bilayer membrane enclosed vesicle after clathrin release and containing glutamate." [GOC:dph] xref: GO:0060199 is_a: CCO:C0000978 ! transport vesicle is_a: CCO:C0002107 ! clathrin sculpted vesicle [Term] id: CCO:C0002109 name: clathrin sculpted acetylcholine transport vesicle namespace: cellular_component def: "A clathrin sculpted lipid bilayer membrane enclosed vesicle after clathrin release and containing acetylcholine." [GOC:dph] xref: GO:0060200 is_a: CCO:C0000978 ! transport vesicle is_a: CCO:C0002107 ! clathrin sculpted vesicle [Term] id: CCO:C0002110 name: clathrin sculpted acetylcholine transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin sculpted acetylcholine transport vesicle." [GOC:dph] xref: GO:0060201 is_a: CCO:C0001023 ! transport vesicle membrane is_a: CCO:C0001029 ! clathrin coated vesicle membrane relationship: part_of CCO:C0002109 ! clathrin sculpted acetylcholine transport vesicle [Term] id: CCO:C0002111 name: clathrin sculpted acetylcholine transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin sculpted acetylcholine transport vesicle." [GOC:dph] xref: GO:0060202 is_a: CCO:C0002132 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of CCO:C0002109 ! clathrin sculpted acetylcholine transport vesicle [Term] id: CCO:C0002112 name: clathrin sculpted glutamate transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin sculpted glutamate transport vesicle." [GOC:dph] xref: GO:0060203 is_a: CCO:C0001023 ! transport vesicle membrane is_a: CCO:C0001029 ! clathrin coated vesicle membrane relationship: part_of CCO:C0002108 ! clathrin sculpted glutamate transport vesicle [Term] id: CCO:C0002113 name: clathrin sculpted glutamate transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin sculpted glutamate transport vesicle." [GOC:dph] xref: GO:0060204 is_a: CCO:C0002132 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of CCO:C0002108 ! clathrin sculpted glutamate transport vesicle [Term] id: CCO:C0002115 name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex namespace: cellular_component def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT [] synonym: "class IA PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IA" EXACT [] xref: GO:0005943 xref: GO:0035030 is_a: CCO:C0000492 ! phosphoinositide 3-kinase complex [Term] id: CCO:C0002116 name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex namespace: cellular_component def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED [] synonym: "class IB PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IB" EXACT [] xref: GO:0005944 xref: GO:0035031 is_a: CCO:C0000492 ! phosphoinositide 3-kinase complex [Term] id: CCO:C0002117 name: serine-pyruvate aminotransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW [] xref: GO:0005969 xref: GO:0005970 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0002118 name: CVT complex namespace: cellular_component def: "A receptor-cargo protein complex that is involved in the CVT pathway. In budding yeast, the CVT complex consists of the preApe1p and Atg19p proteins." [GOC:rb, PMID:15659643] synonym: "preAPE1-Atg11p complex" RELATED [] xref: GO:0034270 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0002119 name: phosphatidylinositol 3-kinase complex I namespace: cellular_component def: "A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Atg14p and Vps15p." [GOC:rb, PMID:11157979, PMID:16421251] comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. synonym: "PtdIns-3-kinase complex I" EXACT [] xref: GO:0034271 is_a: CCO:C0000492 ! phosphoinositide 3-kinase complex [Term] id: CCO:C0002120 name: phosphatidylinositol 3-kinase complex II namespace: cellular_component def: "A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, VPS38 and Vps15p." [GOC:rb, PMID:11157979, PMID:16421251] comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. synonym: "PtdIns-3-kinase complex II" EXACT [] xref: GO:0034272 is_a: CCO:C0000492 ! phosphoinositide 3-kinase complex [Term] id: CCO:C0002121 name: Atg1p signaling complex namespace: cellular_component def: "A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p, Atg13p and Atg17p." [GOC:rb, PMID:15743910] synonym: "Atg1p signalling complex" EXACT [] xref: GO:0034273 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0002122 name: Atg12-Atg5-Atg16 complex namespace: cellular_component def: "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p." [GOC:rb, PMID:17986448] xref: GO:0034274 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001863 ! cytoplasmic part [Term] id: CCO:C0002123 name: membrane raft namespace: cellular_component def: "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198] synonym: "GEM domain" RELATED [] synonym: "glycolipid-enriched membrane domain" RELATED [] synonym: "lipid raft" EXACT [] xref: GO:0045121 is_a: CCO:C0001844 ! membrane part [Term] id: CCO:C0002124 name: cytoplasmic membrane-bounded vesicle namespace: cellular_component def: "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "cytoplasmic membrane bounded vesicle" EXACT [] synonym: "cytoplasmic membrane-enclosed vesicle" EXACT [] xref: GO:0016023 is_a: CCO:C0001235 ! cytoplasmic vesicle is_a: CCO:C0002125 ! membrane-bounded vesicle is_a: CCO:C0002129 ! intracellular membrane-bounded organelle [Term] id: CCO:C0002125 name: membrane-bounded vesicle namespace: cellular_component def: "Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer." [GOC:mah] subset: gosubset_prok synonym: "membrane-enclosed vesicle" EXACT [] xref: GO:0031988 is_a: CCO:C0001374 ! vesicle [Term] id: CCO:C0002126 name: host intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "host intracellular membrane-enclosed organelle" EXACT [] xref: GO:0033648 is_a: CCO:C0001592 ! host intracellular organelle [Term] id: CCO:C0002127 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: gosubset_prok synonym: "membrane-enclosed organelle" EXACT [] xref: GO:0043227 is_a: CCO:C0001742 ! organelle [Term] id: CCO:C0002128 name: non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: gosubset_prok synonym: "non-membrane-enclosed organelle" EXACT [] xref: GO:0043228 is_a: CCO:C0001742 ! organelle [Term] id: CCO:C0002129 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "intracellular membrane-enclosed organelle" EXACT [] xref: GO:0043231 is_a: CCO:C0001745 ! intracellular organelle is_a: CCO:C0002127 ! membrane-bounded organelle [Term] id: CCO:C0002130 name: intracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "intracellular non-membrane-enclosed organelle" EXACT [] xref: GO:0043232 is_a: CCO:C0001745 ! intracellular organelle is_a: CCO:C0002128 ! non-membrane-bounded organelle [Term] id: CCO:C0002131 name: extracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl] subset: gosubset_prok synonym: "extracellular non-membrane-enclosed organelle" EXACT [] xref: GO:0043264 is_a: CCO:C0001746 ! extracellular organelle is_a: CCO:C0002128 ! non-membrane-bounded organelle [Term] id: CCO:C0002132 name: cytoplasmic membrane-bounded vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle." [GOC:dph] synonym: "cytoplasmic membrane-enclosed vesicle lumen" EXACT [] xref: GO:0060205 is_a: CCO:C0001749 ! organelle lumen is_a: CCO:C0001852 ! cytoplasmic vesicle part relationship: part_of CCO:C0002124 ! cytoplasmic membrane-bounded vesicle [Term] id: CCO:C0002133 name: extracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] synonym: "extracellular membrane-enclosed organelle" EXACT [] xref: GO:0065010 is_a: CCO:C0001746 ! extracellular organelle [Term] id: CCO:C0002134 name: intracellular immature spore namespace: cellular_component def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172] subset: gosubset_prok synonym: "forespore" RELATED [] xref: GO:0042763 is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0002135 name: ascospore-type prospore namespace: cellular_component def: "An immature spore, of the type observed in ascopore-forming fungi, undergoing development; usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s)." [GOC:go_curators] subset: gosubset_prok synonym: "forespore (sensu Fungi)" BROAD [] xref: GO:0042764 is_a: CCO:C0002134 ! intracellular immature spore [Term] id: CCO:C0002136 name: cell-substrate junction namespace: cellular_component def: "A specialized region of connection between a cell and the extracellular matrix." [GOC:hb] synonym: "cell-matrix junction" EXACT [] xref: GO:0030055 is_a: CCO:C0000936 ! cell junction relationship: part_of CCO:C0000780 ! basolateral plasma membrane [Term] id: CCO:C0002137 name: photosynthetic membrane namespace: cellular_component def: "A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place." [GOC:ds, GOC:mah] xref: GO:0034357 is_a: CCO:C0000766 ! membrane [Term] id: CCO:C0002138 name: plasma lipoprotein particle namespace: cellular_component def: "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." [GOC:expert_pt, GOC:rl] xref: GO:0034358 is_a: CCO:C0001495 ! protein-lipid complex relationship: part_of CCO:C0000237 ! extracellular space [Term] id: CCO:C0002139 name: mature chylomicron namespace: cellular_component def: "A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph." [GOC:expert_pt, GOC:mah, GOC:rl] xref: GO:0034359 is_a: CCO:C0001672 ! chylomicron [Term] id: CCO:C0002140 name: chylomicron remnant namespace: cellular_component def: "A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver." [GOC:expert_pt, GOC:mah, GOC:rl] xref: GO:0034360 is_a: CCO:C0001672 ! chylomicron [Term] id: CCO:C0002141 name: very-low-density lipoprotein particle namespace: cellular_component def: "A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver." [GOC:expert_pt, GOC:mah, GOC:rl] synonym: "very-low-density lipoprotein complex" EXACT [] synonym: "VLDL complex" EXACT [] synonym: "VLDL particle" EXACT [] xref: GO:0034361 is_a: CCO:C0002147 ! triglyceride-rich lipoprotein particle [Term] id: CCO:C0002142 name: low-density lipoprotein particle namespace: cellular_component def: "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triacylglycerol and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver." [GOC:expert_pt, GOC:mah, GOC:rl] synonym: "LDL complex" EXACT [] synonym: "LDL particle" EXACT [] synonym: "low-density lipoprotein complex" EXACT [] xref: GO:0034362 is_a: CCO:C0002138 ! plasma lipoprotein particle [Term] id: CCO:C0002143 name: intermediate-density lipoprotein particle namespace: cellular_component def: "A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL)." [GOC:expert_pt, GOC:mah, GOC:rl] synonym: "IDL complex" EXACT [] synonym: "IDL particle" EXACT [] synonym: "intermediate-density lipoprotein complex" EXACT [] xref: GO:0034363 is_a: CCO:C0002147 ! triglyceride-rich lipoprotein particle [Term] id: CCO:C0002144 name: high-density lipoprotein particle namespace: cellular_component def: "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process." [GOC:expert_pt, GOC:mah, GOC:pd, GOC:rl] synonym: "HDL complex" EXACT [] synonym: "HDL particle" EXACT [] synonym: "HDL2" RELATED [] synonym: "HDL3" RELATED [] synonym: "high-density lipoprotein class complex" EXACT [] xref: GO:0034364 is_a: CCO:C0002138 ! plasma lipoprotein particle [Term] id: CCO:C0002145 name: discoidal high-density lipoprotein particle namespace: cellular_component def: "A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase)." [GOC:expert_pt, GOC:mah, GOC:rl] synonym: "discoidal HDL" EXACT [] synonym: "nascent HDL" EXACT [] synonym: "nascent high-density lipoprotein particle" EXACT [] xref: GO:0034365 is_a: CCO:C0002144 ! high-density lipoprotein particle [Term] id: CCO:C0002146 name: spherical high-density lipoprotein particle namespace: cellular_component def: "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:expert_pt, GOC:mah, GOC:rl] synonym: "mature HDL" EXACT [] synonym: "mature high-density lipoprotein particle" EXACT [] synonym: "spherical HDL" EXACT [] xref: GO:0034366 is_a: CCO:C0002144 ! high-density lipoprotein particle [Term] id: CCO:C0002147 name: triglyceride-rich lipoprotein particle namespace: cellular_component def: "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood." [GOC:mah, GOC:rl] xref: GO:0034385 is_a: CCO:C0002138 ! plasma lipoprotein particle [Term] id: CCO:C0002148 name: Pwp2p-containing subcomplex of 90S preribosome namespace: cellular_component def: "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "25-30 S subcomplex of 90S preribosome" EXACT [] xref: GO:0034388 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001871 ! nucleolar part relationship: part_of CCO:C0001045 ! 90S preribosome [Term] id: CCO:C0002149 name: nuclear periphery namespace: cellular_component def: "The region of the nucleus adjacent to the nuclear envelope." [GOC:krc] xref: GO:0034399 is_a: CCO:C0001847 ! nuclear part [Term] id: CCO:C0002150 name: gerontoplast namespace: cellular_component def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:16151876] xref: GO:0034400 is_a: CCO:C0000664 ! plastid [Term] id: CCO:C0002151 name: fungal-type vacuole namespace: cellular_component def: "The vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mtg_sensu, ISBN:0879693649] synonym: "vacuole (sensu Fungi)" EXACT [] synonym: "vacuole, cell cycle-correlated morphology" EXACT [] xref: GO:0000324 is_a: CCO:C0000060 ! storage vacuole is_a: CCO:C0000061 ! lytic vacuole [Term] id: CCO:C0002152 name: plant-type vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase." [GOC:mtg_sensu, ISBN:0815316208] synonym: "vacuole (sensu Magnoliophyta)" RELATED [] synonym: "vacuole, cell cycle-independent morphology" EXACT [] xref: GO:0000325 is_a: CCO:C0000355 ! vacuole [Term] id: CCO:C0002153 name: fungal-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT [] synonym: "vacuolar lumen (sensu Fungi)" RELATED [] xref: GO:0000328 is_a: CCO:C0000357 ! vacuolar lumen relationship: part_of CCO:C0002151 ! fungal-type vacuole [Term] id: CCO:C0002154 name: fungal-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell." [GOC:krc, GOC:mtg_sensu] synonym: "fungal-type vacuolar membrane" RELATED [] synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT [] synonym: "vacuolar membrane (sensu Fungi)" EXACT [] xref: GO:0000329 is_a: CCO:C0000356 ! vacuolar membrane relationship: part_of CCO:C0002151 ! fungal-type vacuole [Term] id: CCO:C0002155 name: plant-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT [] synonym: "vacuolar lumen (sensu Magnoliophyta)" EXACT [] xref: GO:0000330 is_a: CCO:C0000357 ! vacuolar lumen relationship: part_of CCO:C0002152 ! plant-type vacuole [Term] id: CCO:C0002156 name: Gram-positive-bacterium-type cell wall namespace: cellular_component def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. As in but not restricted to the Gram-positive bacteria." [GOC:mlg, ISBN:0815108893, PMID:0051406910] subset: gosubset_prok synonym: "20-80nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall (sensu Firmicutes)" EXACT [] synonym: "cell wall (sensu Gram-positive Bacteria)" EXACT [] synonym: "cell wall of Gram-positive Bacteria" EXACT [] xref: GO:0009275 is_a: CCO:C0000553 ! peptidoglycan-based cell wall [Term] id: CCO:C0002157 name: Gram-negative-bacterium-type cell wall namespace: cellular_component def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. As in but not restricted to the Gram-negative bacteria." [GOC:mlg, ISBN:0815108893] subset: gosubset_prok synonym: "1-2nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall (sensu Gram-negative Bacteria)" EXACT [] synonym: "cell wall (sensu Proteobacteria)" EXACT [] synonym: "cell wall inner membrane" EXACT [] xref: GO:0009276 is_a: CCO:C0000553 ! peptidoglycan-based cell wall is_a: CCO:C0001880 ! external encapsulating structure part relationship: part_of CCO:C0001000 ! cell envelope [Term] id: CCO:C0002158 name: plant-type cell wall namespace: cellular_component def: "A more or less rigid stucture enclosing the protoplast of a cell and composed of cellulose and pectin and other organic and inorganic substances. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [ISBN:0471245208] synonym: "cell wall (sensu Magnoliophyta)" EXACT [] synonym: "cellulose and pectin-containing cell wall" EXACT [] xref: GO:0009505 is_a: CCO:C0000239 ! cell wall [Term] id: CCO:C0002159 name: plant-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell." [GOC:mtg_sensu, ISBN:0471245208] synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT [] synonym: "tonoplast" EXACT [] synonym: "vacuolar membrane (sensu Magnoliophyta)" EXACT [] xref: GO:0009705 is_a: CCO:C0000356 ! vacuolar membrane relationship: part_of CCO:C0002152 ! plant-type vacuole [Term] id: CCO:C0002160 name: cell envelope Sec complex namespace: cellular_component def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC." [GOC:mtg_sensu, PMID:15223057] subset: gosubset_prok synonym: "plasma membrane Sec complex" RELATED [] synonym: "Sec complex (sensu Bacteria)" EXACT [] xref: GO:0031522 is_a: CCO:C0001750 ! protein complex is_a: CCO:C0001882 ! cell part [Term] id: CCO:C0002161 name: aleurone grain lumen namespace: cellular_component def: "The volume enclosed by the membrane of an aleurone grain." [GOC:rph] xref: GO:0034422 is_a: CCO:C0002132 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of CCO:C0001516 ! aleurone grain [Term] id: CCO:C0002162 name: autophagic vacuole lumen namespace: cellular_component def: "The volume enclosed within the autophagic vacuole membrane." [GOC:rph] comment: Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation. xref: GO:0034423 is_a: CCO:C0000357 ! vacuolar lumen relationship: part_of CCO:C0000358 ! autophagic vacuole [Term] id: CCO:C0002163 name: Vps55/Vps68 complex namespace: cellular_component def: "A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins." [PMID:18216282] xref: GO:0034424 is_a: CCO:C0001750 ! protein complex relationship: part_of CCO:C0000713 ! endosome membrane [Term] id: CCO:C0002164 name: etioplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] xref: GO:0034425 is_a: CCO:C0000654 ! plastid envelope relationship: part_of CCO:C0000642 ! etioplast [Term] id: CCO:C0002165 name: etioplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a etioplast and form the etioplast envelope." [GOC:rph] xref: GO:0034426 is_a: CCO:C0001634 ! plastid membrane relationship: part_of CCO:C0002164 ! etioplast envelope [Term] id: CCO:C0002166 name: monolayer-surrounded lipid storage body outer lipid monolayer namespace: cellular_component def: "The single layer of phopholipids surrounding a lipid storage body." [GOC:rph] synonym: "lipid droplet outer lipid monolayer" RELATED [] synonym: "lipid storage body surface lipid monolayer" EXACT [] synonym: "oil body outer lipid monolayer" EXACT [] synonym: "oleosome outer lipid monolayer" EXACT [] synonym: "spherosome outer lipid monolayer" EXACT [] xref: GO:0034430 is_a: CCO:C0001865 ! intracellular organelle part relationship: part_of CCO:C0000739 ! monolayer-surrounded lipid storage body [Term] id: CCO:C0002167 name: striated muscle dense body namespace: cellular_component def: "A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere." [GOC:kmva, PMID:17492481] xref: GO:0055120 is_a: CCO:C0001868 ! contractile fiber part [Term] id: CCO:F0000001 name: high affinity zinc uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] xref: GO:0000006 is_a: CCO:F0001601 ! zinc ion transmembrane transporter activity [Term] id: CCO:F0000002 name: low-affinity zinc ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0000007 is_a: CCO:F0001601 ! zinc ion transmembrane transporter activity [Term] id: CCO:F0000003 name: alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage." [GOC:mcc, PMID:2644248] xref: EC:2.4.1.- xref: GO:0000009 is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0000004 name: trans-hexaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30] subset: gosubset_prok synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30] xref: EC:2.5.1.30 xref: GO:0000010 xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0000005 name: single-stranded DNA specific endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] xref: GO:0000014 is_a: CCO:F0000917 ! endodeoxyribonuclease activity [Term] id: CCO:F0000006 name: lactase activity namespace: molecular_function def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108] synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108] synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108] xref: EC:3.2.1.108 xref: GO:0000016 xref: MetaCyc:LACTASE-RXN xref: Reactome:20536 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0000007 name: alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage." [GOC:mcc, PMID:10521541] xref: EC:2.4.1.- xref: GO:0000026 is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0000008 name: mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok xref: EC:2.4.1.- xref: GO:0000030 xref: Reactome:7672 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0000009 name: mannosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of an mannosylphosphate group from one compound to another." [GOC:jl] xref: GO:0000031 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0000010 name: alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:mcc, PMID:10521541] xref: EC:2.4.1.- xref: GO:0000033 is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0000011 name: adenine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] subset: gosubset_prok synonym: "ADase activity" EXACT [EC:3.5.4.2] synonym: "adenase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2] xref: EC:3.5.4.2 xref: GO:0000034 xref: MetaCyc:ADENINE-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0000012 name: acyl binding namespace: molecular_function def: "Interacting selectively with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acyl-CoA or acyl binding" BROAD [] xref: GO:0000035 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0000013 name: acyl carrier activity namespace: molecular_function subset: gosubset_prok xref: GO:0000036 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0000014 name: peptidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921] synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12] xref: EC:2.3.2.12 xref: GO:0000048 xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN xref: Reactome:20610 is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0000015 name: tRNA binding namespace: molecular_function def: "Interacting selectively with transfer RNA." [GOC:ai] subset: gosubset_prok xref: GO:0000049 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0000016 name: acyl-CoA binding namespace: molecular_function def: "Interacting selectively with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acyl-CoA or acyl binding" BROAD [] xref: GO:0000062 is_a: CCO:F0001642 ! fatty acid binding is_a: CCO:F0007988 ! coenzyme binding [Term] id: CCO:F0000017 name: L-ornithine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "L-ornithine transporter activity" BROAD [] xref: GO:0000064 xref: Reactome:20635 is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0000018 name: S-adenosylmethionine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] synonym: "S-adenosyl methionine permease activity" EXACT [] synonym: "S-adenosyl methionine transporter activity" EXACT [] synonym: "S-adenosylmethionine permease activity" EXACT [] synonym: "S-adenosylmethionine transporter activity" BROAD [] xref: GO:0000095 xref: GO:0015177 is_a: CCO:F0000019 ! sulfur amino acid transmembrane transporter activity is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0000019 name: sulfur amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sulfur amino acid transporter activity" BROAD [] synonym: "sulphur amino acid transmembrane transporter activity" EXACT [] synonym: "sulphur amino acid transporter activity" BROAD [] xref: GO:0000099 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0000020 name: S-methylmethionine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "S-methylmethionine permease activity" EXACT [] synonym: "S-methylmethionine transporter activity" BROAD [] xref: GO:0000100 xref: GO:0015178 is_a: CCO:F0000019 ! sulfur amino acid transmembrane transporter activity [Term] id: CCO:F0000021 name: L-methionine secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "L-methionine porter activity" RELATED [] xref: GO:0000102 is_a: CCO:F0001541 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: CCO:F0002665 ! L-methionine transmembrane transporter activity [Term] id: CCO:F0000022 name: succinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. No reaction with quinols." [EC:1.3.99.1, GOC:kd] subset: gosubset_prok synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1] synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1] synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1] xref: EC:1.3.99.1 xref: GO:0000104 xref: GO:0019739 xref: MetaCyc:SUCC-FUM-OXRED-RXN xref: Reactome:21566 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0000023 name: imidazoleglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + AICAR + L-glutamate." [MetaCyc:GLUTAMIDOTRANS-RXN] subset: gosubset_prok synonym: "glutamine amidotransferase:cyclase activity" BROAD [] synonym: "imidazole glycerol phosphate synthase activity" EXACT [] synonym: "imidazole-glycerol-phosphate synthase activity" RELATED [] synonym: "imidazoleglycerol phosphate synthase activity" EXACT [] xref: EC:2.4.2.- xref: GO:0000107 xref: MetaCyc:GLUTAMIDOTRANS-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000024 name: glycerol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21] synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21] xref: EC:3.1.3.21 xref: GO:0000121 xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0000025 name: acylglycerone-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+." [EC:1.1.1.101] synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT [] synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101] synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] xref: EC:1.1.1.101 xref: GO:0000140 xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN xref: Reactome:21659 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000026 name: microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] synonym: "actin filament motor activity" EXACT [GOC:dph] synonym: "actin-filament motor activity" EXACT [] synonym: "muscle motor activity" NARROW [] synonym: "myosin ATPase activity" RELATED [] xref: GO:0000146 is_a: CCO:F0000321 ! motor activity [Term] id: CCO:F0000027 name: SNARE binding namespace: molecular_function def: "Interacting selectively with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] synonym: "SNAP receptor binding" EXACT [] xref: GO:0000149 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000028 name: recombinase activity namespace: molecular_function def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] comment: Consider also annotating to the molecular function terms 'double-stranded DNA binding ; GO:0003690' and 'single-stranded DNA binding ; GO:0003697'. Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. subset: gosubset_prok synonym: "strand transferase" NARROW [] xref: GO:0000150 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0000029 name: two-component sensor activity namespace: molecular_function def: "Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell." [GOC:mah] subset: gosubset_prok synonym: "two-component sensor molecule" NARROW [] synonym: "two-component system sensor activity " EXACT [] xref: EC:2.7.3.- xref: GO:0000155 is_a: CCO:F0001044 ! protein histidine kinase activity is_a: CCO:F0001225 ! signal transducer activity [Term] id: CCO:F0000030 name: two-component response regulator activity namespace: molecular_function def: "Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell." [GOC:mah] subset: gosubset_prok xref: GO:0000156 is_a: CCO:F0001225 ! signal transducer activity is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0000031 name: nucleotide binding namespace: molecular_function def: "Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety." [GOC:mah, ISBN:0198547684] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: GO:0000166 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0000032 name: sphingosine hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] xref: GO:0000170 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0000033 name: ribonuclease MRP activity namespace: molecular_function def: "Catalysis of the first cleavage in rRNA transcript processing, also involved in mitochondrial RNA processing." [PMID:10690410] synonym: "RNase MRP" EXACT [] xref: GO:0000171 is_a: CCO:F0000934 ! ribonuclease activity [Term] id: CCO:F0000034 name: 3'-5'-exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "3'-5' exoribonuclease activity" EXACT [] xref: EC:3.1.13.- xref: GO:0000175 is_a: CCO:F0001875 ! 3'-5' exonuclease activity is_a: CCO:F0003454 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0000035 name: rRNA (adenine-N6,N6-)-dimethyltransferase activity namespace: molecular_function def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337 "Modification and Editing of RNA", PMID:10690410] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0000179 is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0003155 ! rRNA (adenine) methyltransferase activity [Term] id: CCO:F0000036 name: rDNA binding namespace: molecular_function def: "Interacting selectively with DNA sequences encoding ribosomal RNA." [GOC:mah] synonym: "ribosomal DNA binding" EXACT [] xref: GO:0000182 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0000037 name: NAD+ diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] subset: gosubset_prok synonym: "NAD diphosphatase activity" EXACT [] synonym: "NAD pyrophosphatase activity" EXACT [] synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NADH pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NADP pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22] xref: EC:3.6.1.22 xref: GO:0000210 xref: MetaCyc:NADPYROPHOSPHAT-RXN is_a: CCO:F0000937 ! nucleotide diphosphatase activity [Term] id: CCO:F0000038 name: tRNA-intron endonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9] xref: EC:3.1.27.9 xref: GO:0000213 xref: MetaCyc:3.1.27.9-RXN is_a: CCO:F0000935 ! tRNA-specific ribonuclease activity is_a: CCO:F0003450 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0000039 name: tRNA 2'-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O; transfers the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "Tpt1" RELATED [EC:2.7.1.160] synonym: "Tpt1p" RELATED [EC:2.7.1.160] synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] xref: EC:2.7.1.160 xref: GO:0000215 is_a: CCO:F0002025 ! 2'-phosphotransferase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000040 name: DNA secondary structure binding namespace: molecular_function def: "Interacting selectively with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc] xref: GO:0000217 is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0000041 name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] subset: gosubset_prok synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52] synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52] synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52] synonym: "N-glycanase activity" RELATED [EC:3.5.1.52] synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52] synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52] synonym: "peptide:N-glycanase" RELATED [] synonym: "PNGase" EXACT [] synonym: "PNGase A" RELATED [EC:3.5.1.52] synonym: "PNGase F" RELATED [EC:3.5.1.52] xref: EC:3.5.1.52 xref: GO:0000224 xref: MetaCyc:3.5.1.52-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000042 name: N-acetylglucosaminylphosphatidylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the N-deacetylation of GlcNAc-PI to GlcN-PI." [EC:3.5.1.89] comment: Note that this function was formerly EC:3.1.1.69. synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89] synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89] xref: EC:3.5.1.89 xref: GO:0000225 xref: MetaCyc:3.1.1.69-RXN xref: Reactome:22619 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0000043 name: oxaloacetate secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "oxaloacetate carrier activity" RELATED [] xref: GO:0000227 is_a: CCO:F0002608 ! oxaloacetate transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0000044 name: phosphoethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103] synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103] xref: EC:2.1.1.103 xref: GO:0000234 xref: MetaCyc:2.1.1.103-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0000045 name: delta24(24-1) sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3-beta-ol + NADPH + H+." [EC:1.3.1.71, PMID:10722850] subset: gosubset_prok synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "D24(24-1)-sterol reductase activity" EXACT [] synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta-24(28) methylene reductase activity" EXACT [] synonym: "sterol delta-24(28) reductase activity" EXACT [] synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71] xref: EC:1.3.1.71 xref: GO:0000246 xref: MetaCyc:1.3.1.71-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000046 name: C-8 sterol isomerase activity namespace: molecular_function def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [UniProtKB:P32352] synonym: "delta-8-delta-7 sterol isomerase activity" EXACT [] xref: EC:5.3.3.- xref: GO:0000247 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0000047 name: C-5 sterol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] synonym: "sterol-C5-desaturase activity" EXACT [] xref: GO:0000248 is_a: CCO:F0003300 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: CCO:F0000048 name: C-22 sterol desaturase activity namespace: molecular_function def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction is 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227, UniProtKB:P54781] xref: GO:0000249 is_a: CCO:F0003300 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: CCO:F0000049 name: lanosterol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7] subset: gosubset_prok synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT [] synonym: "2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-oxidosqualene sterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7] synonym: "OSC" EXACT [] synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "oxidosqualene-lanosterol cyclase activity" EXACT [] synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581] synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "squalene epoxidase-cyclase activity" EXACT [EC:5.4.99.7] synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7] xref: EC:5.4.99.7 xref: GO:0000250 xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN xref: Reactome:22668 is_a: CCO:F0004686 ! oxidosqualene cyclase activity [Term] id: CCO:F0000050 name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT [] synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [] synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED [] synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED [] synonym: "C-3 sterol dehydrogenase activity" RELATED [] synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED [] synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [] synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED [] xref: EC:1.1.1.- xref: GO:0000252 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000051 name: 3-keto sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+." [EC:1.1.1.270, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] xref: EC:1.1.1.- xref: GO:0000253 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000052 name: C-4 methylsterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4-methylsterol oxidase activity" EXACT [] synonym: "methylsterol hydroxylase activity" RELATED [] synonym: "methylsterol monooxygenase activity" RELATED [] xref: EC:1.14.13.72 xref: GO:0000254 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000053 name: nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] subset: gosubset_prok synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1] synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1] synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1] xref: EC:3.5.5.1 xref: GO:0000257 xref: MetaCyc:3.5.5.1-RXN xref: UM-BBD_enzymeID:e0283 is_a: CCO:F0003384 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: CCO:F0000054 name: peroxisome targeting sequence binding namespace: molecular_function def: "Interacting selectively with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568] synonym: "peroxisome targeting signal receptor" NARROW [] synonym: "PTS binding" EXACT [] synonym: "PTS receptor" NARROW [] xref: GO:0000268 xref: GO:0005051 is_a: CCO:F0001368 ! signal sequence binding [Term] id: CCO:F0000055 name: toxin export channel activity namespace: molecular_function def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] xref: GO:0000269 is_a: CCO:F0002739 ! porin activity is_a: CCO:F0004142 ! toxin transporter activity [Term] id: CCO:F0000057 name: 1-phosphatidylinositol-3-phosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [EC:2.7.1.150] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT [] synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150] xref: EC:2.7.1.150 xref: GO:0000285 xref: MetaCyc:2.7.1.150-RXN is_a: CCO:F0003116 ! phosphatidylinositol phosphate kinase activity [Term] id: CCO:F0000058 name: alanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+." [EC:1.4.1.1] subset: gosubset_prok synonym: "AlaDH" RELATED [EC:1.4.1.1] synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1] synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1] synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] xref: EC:1.4.1.1 xref: GO:0000286 xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0000059 name: magnesium ion binding namespace: molecular_function def: "Interacting selectively with magnesium (Mg) ions." [GOC:ai] subset: gosubset_prok synonym: "magnesium binding" EXACT [] xref: GO:0000287 is_a: CCO:F0006257 ! metal ion binding [Term] id: CCO:F0000060 name: ferric-chelate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H+." [EC:1.16.1.7] comment: Note that this function was formerly EC:1.6.99.13. synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7] synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7] synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7] xref: EC:1.16.1.7 xref: GO:0000293 xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN is_a: CCO:F0003305 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: CCO:F0000061 name: adenine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other." [PMID:11566870] xref: GO:0000295 is_a: CCO:F0002687 ! purine nucleotide transmembrane transporter activity [Term] id: CCO:F0000062 name: spermine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai] xref: GO:0000297 is_a: CCO:F0002675 ! polyamine transmembrane transporter activity [Term] id: CCO:F0000063 name: endopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10] synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10] xref: EC:3.6.1.10 xref: GO:0000298 xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0000064 name: nicotinamide-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] subset: gosubset_prok synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1] synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1] synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1] synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1] synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1] synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMNAT activity" NARROW [EC:2.7.7.1] xref: EC:2.7.7.1 xref: GO:0000309 xref: MetaCyc:2.7.7.1-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000065 name: xanthine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate; substrate specificity for xanthine." [EC:2.4.2.22, GOC:clt] subset: gosubset_prok synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT [] synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] xref: EC:2.4.2.22 xref: GO:0000310 xref: GO:0009043 xref: MetaCyc:XANPRIBOSYLTRAN-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000066 name: methionine-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine S-oxide + thioredoxin = L-methionine + thioredoxin disulfide. Thioredoxin disulfide is the oxidized form of thioredoxin. No reaction on oxidized methionine in peptide linkage." [PMID:11169920] subset: gosubset_prok synonym: "methionine sulfoxide reductase activity" EXACT [] xref: GO:0000317 xref: MetaCyc:METHIONINE-S-OXIDE-REDUCTASE-RXN is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0000067 name: protein-methionine-R-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.-, PMID:11929995] subset: gosubset_prok synonym: "(protein) methionine-R-sulfoxide reductase activity" EXACT [] xref: EC:1.8.4.- xref: GO:0000318 is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0000068 name: sulfite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfite ions from one side of a membrane to the other." [GOC:as] synonym: "sulphite transporter activity" EXACT [] xref: GO:0000319 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0000069 name: template for synthesis of G-rich strand of telomere DNA activity namespace: molecular_function def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242] synonym: "telomerase RNA" EXACT [] synonym: "telomerase, template" EXACT [] xref: GO:0000332 is_a: CCO:F0000090 ! base pairing with DNA relationship: part_of CCO:F0000306 ! telomerase activity [Term] id: CCO:F0000070 name: 3-hydroxyanthranilate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde." [EC:1.13.11.6] subset: gosubset_prok synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3HAO" RELATED [EC:1.13.11.6] xref: EC:1.13.11.6 xref: GO:0000334 xref: MetaCyc:1.13.11.6-RXN xref: Reactome:23302 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0000071 name: RNA cap binding namespace: molecular_function def: "Interacting selectively with a 7-methylguanosine (m7G) moiety or derivative located at the 5' end of an RNA molecule." [GOC:krc] synonym: "binding to mRNA cap" NARROW [] synonym: "mRNA cap binding" NARROW [] synonym: "snRNA cap binding" NARROW [] xref: GO:0000339 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0000072 name: RNA 7-methylguanosine cap binding namespace: molecular_function def: "Interacting selectively with the 7-methylguanosine moiety added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc] synonym: "RNA m7G cap binding" EXACT [] xref: GO:0000340 is_a: CCO:F0000071 ! RNA cap binding [Term] id: CCO:F0000073 name: RNA trimethylguanosine cap binding namespace: molecular_function def: "Interacting selectively with the trimethylguanosine (m(3)(2,2,7)-GTP) moiety located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc] synonym: "RNA m2,2,7G cap binding" EXACT [] xref: GO:0000341 is_a: CCO:F0000071 ! RNA cap binding [Term] id: CCO:F0000074 name: RNA cap 4 binding namespace: molecular_function def: "Interacting selectively with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975] xref: GO:0000342 is_a: CCO:F0000071 ! RNA cap binding [Term] id: CCO:F0000079 name: first spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897] synonym: "lariat formation, 5'-splice site cleavage" NARROW [] xref: GO:0000384 is_a: CCO:F0004638 ! RNA splicing factor activity, transesterification mechanism [Term] id: CCO:F0000081 name: second spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "lariat formation, 5'-splice site cleavage" NARROW [] xref: GO:0000386 is_a: CCO:F0004638 ! RNA splicing factor activity, transesterification mechanism [Term] id: CCO:F0000082 name: four-way junction DNA binding namespace: molecular_function def: "Interacting selectively with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "forked DNA binding" BROAD [] synonym: "Holliday junction binding" EXACT [] xref: GO:0000400 is_a: CCO:F0000040 ! DNA secondary structure binding [Term] id: CCO:F0000083 name: open form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "open form Holliday junction binding" EXACT [] xref: GO:0000401 is_a: CCO:F0000082 ! four-way junction DNA binding [Term] id: CCO:F0000084 name: crossed form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "crossed form Holliday junction binding" EXACT [] xref: GO:0000402 is_a: CCO:F0000082 ! four-way junction DNA binding [Term] id: CCO:F0000085 name: Y-form DNA binding namespace: molecular_function def: "Interacting selectively with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] synonym: "forked DNA binding" BROAD [] synonym: "slayed Y-form DNA binding" EXACT [] xref: GO:0000403 is_a: CCO:F0000040 ! DNA secondary structure binding [Term] id: CCO:F0000086 name: loop DNA binding namespace: molecular_function def: "Interacting selectively with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730] xref: GO:0000404 is_a: CCO:F0000040 ! DNA secondary structure binding is_a: CCO:F0004951 ! DNA insertion or deletion binding [Term] id: CCO:F0000087 name: bubble DNA binding namespace: molecular_function def: "Interacting selective with DNA that contains a bubble. A bubble occurs when DNA contains an region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, PMID:16781730] xref: GO:0000405 is_a: CCO:F0000040 ! DNA secondary structure binding [Term] id: CCO:F0000088 name: double-strand/single-strand DNA junction binding namespace: molecular_function def: "Interacting selectively with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730] xref: GO:0000406 is_a: CCO:F0000040 ! DNA secondary structure binding [Term] id: CCO:F0000089 name: base pairing namespace: molecular_function def: "Interacting selectively with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: GO:0000496 is_a: CCO:F0000273 ! nucleic acid binding [Term] id: CCO:F0000090 name: base pairing with DNA namespace: molecular_function def: "Interacting selectively with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: GO:0000497 is_a: CCO:F0000089 ! base pairing is_a: CCO:F0000274 ! DNA binding [Term] id: CCO:F0000091 name: base pairing with RNA namespace: molecular_function def: "Interacting selectively with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: GO:0000498 is_a: CCO:F0000089 ! base pairing is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0000092 name: base pairing with mRNA namespace: molecular_function def: "Interacting selectively with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: GO:0000499 is_a: CCO:F0000091 ! base pairing with RNA [Term] id: CCO:F0000093 name: mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623] xref: GO:0000700 is_a: CCO:F0004051 ! DNA N-glycosylase activity [Term] id: CCO:F0000094 name: purine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623] synonym: "A/G-specific adenine DNA glycosylase activity" NARROW [] xref: EC:3.2.2.- xref: GO:0000701 is_a: CCO:F0000093 ! mismatch base pair DNA N-glycosylase activity [Term] id: CCO:F0000095 name: oxidized base lesion DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] subset: gosubset_prok xref: GO:0000702 is_a: CCO:F0004051 ! DNA N-glycosylase activity [Term] id: CCO:F0000096 name: oxidized pyrimidine base lesion DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:elh, PMID:11554296] subset: gosubset_prok synonym: "bifunctional DNA glycosylase" BROAD [] synonym: "DNA glycosylase/AP-lyase" BROAD [] synonym: "DNA glycosylase/beta-lyase" BROAD [] synonym: "endodeoxyribonuclease III" RELATED [] synonym: "endonuclease III" RELATED [] synonym: "endonuclease VIII activity" RELATED [] synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: GO:0000703 xref: GO:0019004 xref: Reactome:25087 is_a: CCO:F0000095 ! oxidized base lesion DNA N-glycosylase activity is_a: CCO:F0000411 ! DNA-(apurinic or apyrimidinic site) lyase activity is_a: CCO:F0000917 ! endodeoxyribonuclease activity [Term] id: CCO:F0000097 name: pyrimidine dimer DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623] xref: GO:0000704 is_a: CCO:F0000411 ! DNA-(apurinic or apyrimidinic site) lyase activity is_a: CCO:F0000917 ! endodeoxyribonuclease activity is_a: CCO:F0004051 ! DNA N-glycosylase activity [Term] id: CCO:F0000099 name: DNA strand annealing activity namespace: molecular_function def: "Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh] xref: GO:0000739 is_a: CCO:F0000282 ! double-stranded DNA binding is_a: CCO:F0000288 ! single-stranded DNA binding [Term] id: CCO:F0000100 name: mating pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh] xref: GO:0000772 is_a: CCO:F0001483 ! pheromone activity [Term] id: CCO:F0000101 name: phosphatidyl-N-methylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71] subset: gosubset_prok synonym: "methyltransferase II" RELATED [EC:2.1.1.71] synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71] synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "PLMT" EXACT [] synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71] xref: EC:2.1.1.71 xref: GO:0000773 xref: MetaCyc:2.1.1.71-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0000102 name: adenyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] subset: gosubset_prok xref: GO:0000774 is_a: CCO:F0004466 ! adenyl nucleotide binding [Term] id: CCO:F0000103 name: diacylglycerol pyrophosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diacylglycerol pyrophosphate + H20 = 3-sn-phosphatidate + phosphate." [EC:3.6.1.-, PMID:8567632, PMID:9452443] synonym: "DGPP phosphatase activity" EXACT [] synonym: "DGPP phosphohydrolase activity" EXACT [] xref: GO:0000810 is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0000104 name: nicotinamide riboside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinamide riboside = ADP + nicotinamide nucleotide (NMN)." [PMID:15137942] xref: GO:0000816 is_a: CCO:F0004129 ! nucleoside kinase activity [Term] id: CCO:F0000105 name: inositol hexakisphosphate binding namespace: molecular_function def: "Interacting selectively with inositol hexakisphosphate." [GOC:go_curator] synonym: "InsP6 binding" EXACT [] synonym: "IP6 binding" EXACT [] xref: GO:0000822 is_a: CCO:F0005812 ! alcohol binding [Term] id: CCO:F0000106 name: inositol trisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate." [GOC:elh] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [] synonym: "EC:2.7.1.151" BROAD [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] xref: GO:0000823 is_a: CCO:F0008191 ! inositol trisphosphate kinase activity [Term] id: CCO:F0000107 name: inositol tetrakisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "EC:2.7.1.151" BROAD [] synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] xref: GO:0000824 is_a: CCO:F0008190 ! inositol tetrakisphosphate kinase activity [Term] id: CCO:F0000108 name: inositol tetrakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT [] synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT [] xref: GO:0000825 is_a: CCO:F0008190 ! inositol tetrakisphosphate kinase activity [Term] id: CCO:F0000109 name: inositol pyrophosphate synthase activity namespace: molecular_function def: "Catalysis of the phosphorylation of inositol phosphates which possess pyrophosphate bonds." [GOC:elh, PMID:16429326] synonym: "inositol diphosphate synthase activity" EXACT [] xref: GO:0000826 is_a: CCO:F0000836 ! inositol or phosphatidylinositol kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0000110 name: inositol 1,3,4,5,6-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [GOC:elh, PMID:11311242] synonym: "EC:2.7.4.21" BROAD [] xref: GO:0000827 is_a: CCO:F0000109 ! inositol pyrophosphate synthase activity [Term] id: CCO:F0000111 name: inositol hexakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate (IP6) = ADP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown)." [GOC:elh, PMID:16429326] xref: GO:0000828 is_a: CCO:F0000109 ! inositol pyrophosphate synthase activity [Term] id: CCO:F0000112 name: inositol heptakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown) = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4; isomer unknown)." [GOC:elh, PMID:16429326] xref: GO:0000829 is_a: CCO:F0000109 ! inositol pyrophosphate synthase activity [Term] id: CCO:F0000113 name: inositol hexakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326] xref: GO:0000830 is_a: CCO:F0005070 ! inositol hexakisphosphate 4-kinase or 6-kinase activity [Term] id: CCO:F0000114 name: inositol hexakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326] xref: GO:0000831 is_a: CCO:F0005070 ! inositol hexakisphosphate 4-kinase or 6-kinase activity [Term] id: CCO:F0000115 name: inositol hexakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [GOC:elh, PMID:16429326] synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [] synonym: "EC:2.7.4.21" BROAD [] xref: GO:0000832 is_a: CCO:F0000111 ! inositol hexakisphosphate kinase activity [Term] id: CCO:F0000116 name: inositol heptakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326] synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT [] synonym: "IP7 4-kinase activity" EXACT [] xref: GO:0000833 is_a: CCO:F0005076 ! inositol heptakisphosphate 4-kinase or 6-kinase activity [Term] id: CCO:F0000117 name: inositol heptakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326] xref: GO:0000834 is_a: CCO:F0005076 ! inositol heptakisphosphate 4-kinase or 6-kinase activity [Term] id: CCO:F0000118 name: translation repressor activity, nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid." [GOC:clt] xref: GO:0000900 is_a: CCO:F0001739 ! translation factor activity, nucleic acid binding is_a: CCO:F0004416 ! translation repressor activity [Term] id: CCO:F0000119 name: translation repressor activity, non-nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt] xref: GO:0000901 is_a: CCO:F0004416 ! translation repressor activity is_a: CCO:F0006095 ! translation factor activity, non-nucleic acid binding [Term] id: CCO:F0000120 name: 6,7-dimethyl-8-ribityllumazine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [EC:5.4.-.-, PMID:7559556] synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] xref: EC:5.4.-.- xref: GO:0000906 is_a: CCO:F0003428 ! intramolecular transferase activity, transferring acyl groups [Term] id: CCO:F0000121 name: sulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536] subset: gosubset_prok synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT [] synonym: "sulphonate dioxygenase activity" EXACT [] xref: EC:1.14.11.- xref: GO:0000907 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0000122 name: taurine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: taurine + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.17, MetaCyc:RXN0-299] subset: gosubset_prok synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17] xref: EC:1.14.11.17 xref: GO:0000908 xref: MetaCyc:RXN0-299 is_a: CCO:F0000121 ! sulfonate dioxygenase activity [Term] id: CCO:F0000123 name: base pairing with rRNA namespace: molecular_function def: "Interacting selectively with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: GO:0000944 is_a: CCO:F0000091 ! base pairing with RNA is_a: CCO:F0004192 ! rRNA binding [Term] id: CCO:F0000124 name: base pairing with snRNA namespace: molecular_function def: "Interacting selectively with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: GO:0000945 is_a: CCO:F0000091 ! base pairing with RNA is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0000125 name: base pairing with tRNA namespace: molecular_function def: "Interacting selectively with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: GO:0000946 is_a: CCO:F0000015 ! tRNA binding is_a: CCO:F0000091 ! base pairing with RNA [Term] id: CCO:F0000126 name: glycerophosphodiester transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] xref: GO:0001406 is_a: CCO:F0002968 ! organophosphate ester transmembrane transporter activity [Term] id: CCO:F0000127 name: guanine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other." [GOC:mcc] xref: GO:0001409 is_a: CCO:F0002687 ! purine nucleotide transmembrane transporter activity [Term] id: CCO:F0000128 name: legumain activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34] synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "citvac" RELATED [EC:3.4.22.34] synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34] synonym: "phaseolin activity" RELATED [EC:3.4.22.34] synonym: "proteinase B" RELATED [EC:3.4.22.34] synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34] synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34] xref: EC:3.4.22.34 xref: GO:0001509 xref: MetaCyc:3.4.22.34-RXN is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0000129 name: dihydronicotinamide riboside quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2] synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2] synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2] synonym: "NQO(2) activity" EXACT [EC:1.10.99.2] synonym: "NQO2" RELATED [EC:1.10.99.2] synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2] synonym: "QR2 activity" RELATED [EC:1.10.99.2] synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2] synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [] xref: EC:1.10.99.2 xref: GO:0001512 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0000130 name: opioid peptide activity namespace: molecular_function def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0001515 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0000131 name: N-acetylglucosamine 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0001517 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0000132 name: lipopolysaccharide binding namespace: molecular_function def: "Interacting selectively with lipopolysaccharide." [PMID:11079463] synonym: "endotoxin binding" BROAD [] synonym: "LPS binding" EXACT [] xref: GO:0001530 is_a: CCO:F0000239 ! pattern binding [Term] id: CCO:F0000133 name: interleukin-21 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-21 receptor." [GOC:ai] synonym: "IL-21" NARROW [] synonym: "interleukin-21 receptor ligand" NARROW [] xref: GO:0001531 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0000134 name: interleukin-21 receptor activity namespace: molecular_function def: "Combining with interleukin-21 to initiate a change in cell activity." [GOC:jl] synonym: "IL-21R" EXACT [] xref: GO:0001532 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004241 ! interleukin-21 binding [Term] id: CCO:F0000135 name: N-acetylgalactosamine 4-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai] synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0001537 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0000136 name: beta-amyloid binding namespace: molecular_function def: "Interacting selectively with beta-amyloid peptide/protein and/or its precursor." [GOC:hjd] xref: GO:0001540 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000137 name: phorbol ester receptor activity namespace: molecular_function def: "Combining with a phorbol ester to initiate a change in cell activity." [GOC:ai, PMID:10506570] xref: GO:0001565 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0000138 name: non-kinase phorbol ester receptor activity namespace: molecular_function def: "Phorbol ester/diacylglycerol binding proteins that do not have intrinsic kinase activity." [PMID:10506570] xref: GO:0001566 is_a: CCO:F0000137 ! phorbol ester receptor activity [Term] id: CCO:F0000139 name: cholesterol 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O." [EC:1.14.99.38] synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38] synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38] xref: EC:1.14.99.38 xref: GO:0001567 is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0000140 name: non-tyrosine kinase fibroblast growth factor receptor activity namespace: molecular_function def: "A receptor belonging to the FGFR family but lacking the tyrosine kinase domain." [PMID:11418238] synonym: "non-tyrosine kinase FGF receptor activity" EXACT [] synonym: "non-tyrosine kinase FGFR activity" EXACT [] xref: GO:0001571 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0000141 name: rhodopsin-like receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:tb, IUPHAR:2.1] subset: gosubset_prok synonym: "Class A G protein coupled receptor" EXACT [] synonym: "Class A G-protein coupled receptor" EXACT [] synonym: "Class A GPCR" EXACT [] synonym: "class A orphan receptor activity" EXACT [] xref: GO:0001584 xref: GO:0001620 is_a: CCO:F0001272 ! G-protein coupled receptor activity [Term] id: CCO:F0000142 name: 5-HT1 receptor activity namespace: molecular_function xref: GO:0001586 is_a: CCO:F0001331 ! serotonin receptor activity [Term] id: CCO:F0000143 name: 5-HT2 receptor activity namespace: molecular_function xref: GO:0001587 is_a: CCO:F0001331 ! serotonin receptor activity [Term] id: CCO:F0000144 name: dopamine D1 receptor-like receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds the neurotransmitter dopamine and activates adenylate cyclase via coupling to Gs." [ISBN:0953351033] xref: GO:0001588 is_a: CCO:F0001294 ! dopamine receptor activity [Term] id: CCO:F0000145 name: dopamine D5 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D5 receptors." [IUPHAR:2.1] xref: GO:0001589 is_a: CCO:F0000144 ! dopamine D1 receptor-like receptor activity [Term] id: CCO:F0000146 name: dopamine D1 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D1 receptors." [IUPHAR:21.] xref: GO:0001590 is_a: CCO:F0000144 ! dopamine D1 receptor-like receptor activity [Term] id: CCO:F0000147 name: dopamine D2 receptor-like receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds the neurotransmitter dopamine and inhibits adenylate cyclase via coupling to Gi/Go." [ISBN:0953351033] xref: GO:0001591 is_a: CCO:F0001294 ! dopamine receptor activity [Term] id: CCO:F0000148 name: dopamine D3 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D3 receptors." [IUPHAR:2.1] xref: GO:0001592 is_a: CCO:F0000147 ! dopamine D2 receptor-like receptor activity [Term] id: CCO:F0000149 name: dopamine D4 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D4 receptors." [IUPHAR:2.1] xref: GO:0001593 is_a: CCO:F0000147 ! dopamine D2 receptor-like receptor activity [Term] id: CCO:F0000150 name: trace-amine receptor activity namespace: molecular_function xref: GO:0001594 is_a: CCO:F0001782 ! amine receptor activity [Term] id: CCO:F0000151 name: angiotensin receptor activity namespace: molecular_function def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai] xref: GO:0001595 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0000152 name: angiotensin type I receptor activity namespace: molecular_function xref: GO:0001596 is_a: CCO:F0000151 ! angiotensin receptor activity [Term] id: CCO:F0000153 name: chemokine receptor-like receptor activity namespace: molecular_function xref: GO:0001598 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0000154 name: endothelin-A receptor activity namespace: molecular_function def: "A G-protein coupled receptor that preferentially binds endothelin 1." [IUPHAR:2.1, PMID:8582288] xref: GO:0001599 is_a: CCO:F0001303 ! endothelin receptor activity [Term] id: CCO:F0000155 name: endothelin-B receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds all endothelin molecules with approximately equal affinity." [IUPHAR:2.1, PMID:8582288] xref: GO:0001600 is_a: CCO:F0001303 ! endothelin receptor activity [Term] id: CCO:F0000156 name: peptide YY receptor activity namespace: molecular_function def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606] xref: GO:0001601 is_a: CCO:F0001321 ! neuropeptide Y receptor activity [Term] id: CCO:F0000157 name: pancreatic polypeptide receptor activity namespace: molecular_function def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606] xref: GO:0001602 is_a: CCO:F0001321 ! neuropeptide Y receptor activity [Term] id: CCO:F0000158 name: vasopressin-like receptor activity namespace: molecular_function xref: GO:0001603 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0000159 name: urotensin II receptor activity namespace: molecular_function xref: GO:0001604 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0000160 name: adrenomedullin receptor activity namespace: molecular_function def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai] synonym: "G10D receptor" NARROW [] xref: GO:0001605 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0000161 name: GPR37/endothelin B-like receptor activity namespace: molecular_function xref: GO:0001606 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0000162 name: neuromedin U receptor activity namespace: molecular_function def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai] synonym: "NMUR activity" EXACT [] xref: GO:0001607 is_a: CCO:F0001769 ! neuropeptide receptor activity is_a: CCO:F0005747 ! neuromedin U binding [Term] id: CCO:F0000163 name: nucleotide receptor activity, G-protein coupled namespace: molecular_function def: "A GPCR that binds a nucleotide or nucleotide derivative as its ligand." [GOC:dph, IUPHAR:2.1.NUCT] synonym: "G protein coupled nucleotide receptor activity" EXACT [] synonym: "G-protein-coupled nucleotide receptor activity" EXACT [] synonym: "nucleotide receptor activity, G protein coupled" EXACT [] xref: GO:0001608 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000164 name: adenosine receptor activity, G-protein coupled namespace: molecular_function def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:mah, PMID:9755289] synonym: "A1 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "adenosine nucleotide receptor" BROAD [] synonym: "adenosine receptor activity, G protein coupled" EXACT [] synonym: "G protein coupled A1 adenosine receptor activity" NARROW [] synonym: "G protein coupled A2A adenosine receptor activity" NARROW [] synonym: "G protein coupled A2B adenosine receptor activity" NARROW [] synonym: "G protein coupled A3 adenosine receptor activity" NARROW [] synonym: "G protein coupled adenosine receptor activity" EXACT [] synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled adenosine receptor activity" EXACT [] xref: GO:0001609 xref: GO:0001610 xref: GO:0001611 xref: GO:0001612 xref: GO:0001613 xref: GO:0008501 is_a: CCO:F0006063 ! purinergic nucleotide receptor activity, G-protein coupled [Term] id: CCO:F0000165 name: purinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a purine nucleotide to initiate a change in cell activity." [GOC:mah] synonym: "P2Y receptor" NARROW [] synonym: "purinoceptor" BROAD [] synonym: "purinoreceptor" BROAD [] xref: GO:0001614 is_a: CCO:F0003183 ! nucleotide receptor activity [Term] id: CCO:F0000166 name: thyrotropin releasing hormone and secretagogue-like receptors activity namespace: molecular_function xref: GO:0001615 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000167 name: growth hormone secretagogue receptor activity namespace: molecular_function xref: GO:0001616 is_a: CCO:F0000166 ! thyrotropin releasing hormone and secretagogue-like receptors activity [Term] id: CCO:F0000168 name: growth hormone secretagogue-like receptor activity namespace: molecular_function xref: GO:0001617 is_a: CCO:F0000166 ! thyrotropin releasing hormone and secretagogue-like receptors activity [Term] id: CCO:F0000169 name: viral receptor activity namespace: molecular_function def: "Combining with a virus component to initiate a change in cell activity." [GOC:dph] xref: GO:0001618 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0000170 name: lysosphingolipid and lysophosphatidic acid receptor activity namespace: molecular_function def: "Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph] xref: GO:0001619 is_a: CCO:F0000141 ! rhodopsin-like receptor activity is_a: CCO:F0006072 ! bioactive lipid receptor activity [Term] id: CCO:F0000171 name: platelet ADP receptor activity namespace: molecular_function synonym: "K101 receptor" NARROW [] xref: GO:0001621 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000172 name: super conserved receptor expressed in brain receptor activity namespace: molecular_function synonym: "SREB receptor" EXACT [] xref: GO:0001622 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000173 name: Mas proto-oncogene receptor activity namespace: molecular_function xref: GO:0001623 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000174 name: RDC1 receptor activity namespace: molecular_function xref: GO:0001624 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000175 name: Epstein-Barr Virus-induced receptor activity namespace: molecular_function synonym: "EBV-induced receptor" EXACT [] xref: GO:0001625 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000176 name: nociceptin/orphanin-FQ receptor activity namespace: molecular_function synonym: "ORPH receptor" EXACT [] xref: GO:0001626 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000177 name: leucine-rich G-protein receptor-like receptor activity namespace: molecular_function synonym: "leucine-rich G protein receptor-like receptor activity" EXACT [] synonym: "LGR-like receptor" EXACT [] xref: GO:0001627 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000178 name: gastropyloric receptor activity namespace: molecular_function synonym: "GPR receptor" EXACT [] xref: GO:0001628 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000179 name: G-protein receptor 45-like receptor activity namespace: molecular_function synonym: "G protein receptor 45-like receptor activity" EXACT [] synonym: "GPR45-like receptor" EXACT [] xref: GO:0001629 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000180 name: GP40-like receptor activity namespace: molecular_function xref: GO:0001630 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0000181 name: cysteinyl leukotriene receptor activity namespace: molecular_function def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide moiety based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "CysLT receptor" EXACT [] xref: GO:0001631 is_a: CCO:F0001314 ! leukotriene receptor activity [Term] id: CCO:F0000182 name: leukotriene B4 receptor activity namespace: molecular_function def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "BLT receptor" NARROW [] xref: GO:0001632 is_a: CCO:F0001314 ! leukotriene receptor activity [Term] id: CCO:F0000183 name: secretin-like receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is structurally/functionally related to the secretin receptor." [IUPHAR:2.2] synonym: "class B G protein coupled receptor" EXACT [] synonym: "class B G-protein coupled receptor" EXACT [] synonym: "class B GPCR" EXACT [] synonym: "class B orphan receptor activity" EXACT [] xref: GO:0001633 xref: GO:0001638 is_a: CCO:F0001272 ! G-protein coupled receptor activity [Term] id: CCO:F0000184 name: pituitary adenylate cyclase activating protein receptor activity namespace: molecular_function synonym: "PACAP receptor" EXACT [] synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT [] synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT [] xref: GO:0001634 xref: GO:0016522 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0000185 name: calcitonin gene-related polypeptide receptor activity namespace: molecular_function synonym: "CGRP receptor" EXACT [] xref: GO:0001635 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0000186 name: corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity namespace: molecular_function xref: GO:0001636 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0000187 name: G-protein chemoattractant receptor activity namespace: molecular_function synonym: "G protein chemoattractant receptor activity" EXACT [] xref: GO:0001637 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0000188 name: PLC activating metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303] synonym: "Group I metabotropic glutamate receptor" RELATED [] synonym: "group I metabotropic glutamate receptor activity" RELATED [] synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT [] xref: GO:0001639 is_a: CCO:F0001696 ! metabotropic glutamate, GABA-B-like receptor activity [Term] id: CCO:F0000189 name: adenylate cyclase inhibiting metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity." [GOC:dph] synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT [] xref: GO:0001640 is_a: CCO:F0001696 ! metabotropic glutamate, GABA-B-like receptor activity [Term] id: CCO:F0000190 name: group II metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph] xref: GO:0001641 is_a: CCO:F0000189 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity [Term] id: CCO:F0000191 name: group III metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303] xref: GO:0001642 is_a: CCO:F0000189 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity [Term] id: CCO:F0000192 name: cAMP receptor activity namespace: molecular_function def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) to initiate a change in cell activity." [GOC:pg] synonym: "3',5' cAMP receptor activity" EXACT [] synonym: "3',5'-cAMP receptor activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT [] synonym: "class E G protein coupled receptor" BROAD [] synonym: "class E G-protein coupled receptor" BROAD [] synonym: "class E GPCR" BROAD [] synonym: "cyclic AMP receptor activity" EXACT [] xref: GO:0001644 xref: GO:0001646 is_a: CCO:F0003183 ! nucleotide receptor activity is_a: CCO:F0004464 ! cAMP binding [Term] id: CCO:F0000193 name: G-protein coupled cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin to initiate a change in cell activity. The receptor is G-protein coupled." [GOC:dph] synonym: "G protein coupled cytokinin receptor activity" EXACT [] synonym: "G-protein-coupled cytokinin receptor activity" EXACT [] xref: GO:0001647 is_a: CCO:F0001272 ! G-protein coupled receptor activity is_a: CCO:F0002413 ! cytokinin receptor activity [Term] id: CCO:F0000194 name: proteinase activated receptor activity namespace: molecular_function xref: GO:0001648 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0000195 name: peptide receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] synonym: "endogenous peptide receptor activity" NARROW [] synonym: "exogenous peptide receptor activity" NARROW [] xref: GO:0001653 is_a: CCO:F0001226 ! receptor activity is_a: CCO:F0005639 ! peptide binding [Term] id: CCO:F0000196 name: G-protein-coupled receptor binding namespace: molecular_function def: "Interacting selectively with a G-protein-coupled receptor." [GOC:ceb, GOC:dph] synonym: "G protein coupled receptor binding" EXACT [] synonym: "G protein coupled receptor ligand" NARROW [] synonym: "G-protein-coupled receptor ligand" NARROW [] xref: GO:0001664 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0000197 name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3] synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3] synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3] xref: EC:2.4.99.3 xref: GO:0001665 xref: MetaCyc:2.4.99.3-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0000198 name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-4,5-bisphosphate + H2O = phosphatidyl inositol-4-phosphate + phosphate." [MGD:ajp] xref: EC:3.1.3.- xref: GO:0001668 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity is_a: CCO:F0005684 ! lipid phosphatase activity [Term] id: CCO:F0000199 name: dopamine D2 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D2 receptors." [IUPHAR:2.1] xref: GO:0001670 is_a: CCO:F0000147 ! dopamine D2 receptor-like receptor activity [Term] id: CCO:F0000200 name: ATPase activator activity namespace: molecular_function def: "Functions to increase the rate of ATP hydrolysis." [GOC:ajp] synonym: "ATPase stimulator activity" EXACT [] xref: GO:0001671 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0000201 name: sialate O-acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039] subset: gosubset_prok synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53] synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53] synonym: "sialate 9(4)-O-acetylesterase activity" EXACT [] xref: EC:3.1.1.53 xref: GO:0001681 xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN is_a: CCO:F0001731 ! acetylesterase activity [Term] id: CCO:F0000202 name: pseudophosphatase activity namespace: molecular_function def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp] xref: GO:0001691 is_a: CCO:F0004135 ! phosphatase inhibitor activity [Term] id: CCO:F0000203 name: L-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2." [EC:1.4.3.2] subset: gosubset_prok synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2] synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2] xref: EC:1.4.3.2 xref: GO:0001716 xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0000204 name: lipid kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd] subset: gosubset_prok xref: GO:0001727 is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0000205 name: ceramide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide 1-phosphate." [EC:2.7.1.138] synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138] synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138] xref: EC:2.7.1.138 xref: GO:0001729 xref: MetaCyc:CERAMIDE-KINASE-RXN is_a: CCO:F0000204 ! lipid kinase activity [Term] id: CCO:F0000206 name: 2'-5'-oligoadenylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. Requires binding of double-stranded RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "(2-5')oligo(A) synthetase activity" EXACT [] synonym: "2'-5' oligoadenylate synthetase activity" EXACT [] synonym: "2-5A synthetase activity" EXACT [] synonym: "oligo-2',5'-adenylate synthetase activity" EXACT [] xref: GO:0001730 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000207 name: galactosylceramide sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929] synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "cerebroside sulfotransferase activity" EXACT [] synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactosylceramide sulphotransferase activity" EXACT [] synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "GSase" EXACT [EC:2.8.2.11] xref: EC:2.8.2.11 xref: GO:0001733 xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN is_a: CCO:F0007995 ! galactose 3-O-sulfotransferase activity [Term] id: CCO:F0000208 name: mRNA (N6-adenosine)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R = purine, and H = C, A, or U." [GOC:hjd] xref: GO:0001734 xref: Reactome:2399 is_a: CCO:F0001761 ! mRNA methyltransferase activity [Term] id: CCO:F0000209 name: prenylcysteine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H20 = a prenal + L-cysteine + H202." [GOC:hjd] synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5] synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5] xref: EC:1.8.3.5 xref: GO:0001735 xref: MetaCyc:1.8.3.5-RXN is_a: CCO:F0003263 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor [Term] id: CCO:F0000210 name: retinal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36] synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36] synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36] xref: EC:1.2.1.36 xref: GO:0001758 xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000211 name: aminocarboxymuconate-semialdehyde decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2." [EC:4.1.1.45] subset: gosubset_prok synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45] xref: EC:4.1.1.45 xref: GO:0001760 xref: MetaCyc:4.1.1.45-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000212 name: beta-alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd] synonym: "beta-alanine transporter activity" BROAD [] xref: GO:0001761 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity [Term] id: CCO:F0000213 name: phosphotyrosine binding namespace: molecular_function def: "Interacting selectively with a phosphorylated tyrosine residue within a protein." [PMID:14636584] xref: GO:0001784 is_a: CCO:F0006109 ! protein phosphorylated amino acid binding [Term] id: CCO:F0000214 name: prostaglandin J receptor activity namespace: molecular_function def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180] synonym: "PGJ receptor activity" RELATED [] synonym: "PGJ(2) receptor activity" EXACT [] xref: GO:0001785 is_a: CCO:F0001297 ! prostaglandin receptor activity [Term] id: CCO:F0000215 name: phosphatidylserine binding namespace: molecular_function def: "Interacting selectively with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12000961] xref: GO:0001786 is_a: CCO:F0001666 ! phospholipid binding [Term] id: CCO:F0000216 name: polymeric immunoglobulin binding namespace: molecular_function def: "Interacting selectively with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001790 is_a: CCO:F0004198 ! immunoglobulin binding [Term] id: CCO:F0000217 name: IgM binding namespace: molecular_function def: "Interacting selectively with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001791 is_a: CCO:F0004198 ! immunoglobulin binding [Term] id: CCO:F0000218 name: polymeric immunoglobulin receptor activity namespace: molecular_function def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001792 is_a: CCO:F0000216 ! polymeric immunoglobulin binding is_a: CCO:F0004150 ! immunoglobulin receptor activity [Term] id: CCO:F0000219 name: IgM receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgM isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001793 is_a: CCO:F0000217 ! IgM binding is_a: CCO:F0004150 ! immunoglobulin receptor activity [Term] id: CCO:F0000220 name: opsonin binding namespace: molecular_function def: "Interacting selectively with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. xref: GO:0001846 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000221 name: opsonin receptor activity namespace: molecular_function def: "Combining with an opsonin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001847 is_a: CCO:F0000220 ! opsonin binding is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0000222 name: complement binding namespace: molecular_function def: "Interacting selectively with any component or product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. xref: GO:0001848 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000223 name: complement component C1q binding namespace: molecular_function def: "Interacting selectively with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001849 is_a: CCO:F0000220 ! opsonin binding is_a: CCO:F0000222 ! complement binding [Term] id: CCO:F0000224 name: complement component C3a binding namespace: molecular_function def: "Interacting selectively with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001850 is_a: CCO:F0000222 ! complement binding [Term] id: CCO:F0000225 name: complement component C3b binding namespace: molecular_function def: "Interacting selectively with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001851 is_a: CCO:F0000220 ! opsonin binding is_a: CCO:F0000222 ! complement binding [Term] id: CCO:F0000226 name: complement component iC3b binding namespace: molecular_function def: "Interacting selectively with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001852 is_a: CCO:F0000220 ! opsonin binding is_a: CCO:F0000222 ! complement binding [Term] id: CCO:F0000227 name: complement component C3dg binding namespace: molecular_function def: "Interacting selectively with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001853 is_a: CCO:F0000222 ! complement binding [Term] id: CCO:F0000228 name: complement component C3d binding namespace: molecular_function def: "Interacting selectively with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001854 is_a: CCO:F0000222 ! complement binding [Term] id: CCO:F0000229 name: complement component C4b binding namespace: molecular_function def: "Interacting selectively with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001855 is_a: CCO:F0000220 ! opsonin binding is_a: CCO:F0000222 ! complement binding [Term] id: CCO:F0000230 name: complement component C5a binding namespace: molecular_function def: "Interacting selectively with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001856 is_a: CCO:F0000222 ! complement binding [Term] id: CCO:F0000231 name: complement component C1q receptor activity namespace: molecular_function def: "Combining with the C1q component of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001857 is_a: CCO:F0000221 ! opsonin receptor activity is_a: CCO:F0000223 ! complement component C1q binding is_a: CCO:F0001229 ! complement receptor activity [Term] id: CCO:F0000232 name: complement component iC3b receptor activity namespace: molecular_function def: "Combining with the iC3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001858 is_a: CCO:F0000221 ! opsonin receptor activity is_a: CCO:F0000226 ! complement component iC3b binding is_a: CCO:F0001229 ! complement receptor activity [Term] id: CCO:F0000233 name: complement component C3dg receptor activity namespace: molecular_function def: "Combining with the C3dg product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001859 is_a: CCO:F0001229 ! complement receptor activity [Term] id: CCO:F0000234 name: complement component C3d receptor activity namespace: molecular_function def: "Combining with the C3d product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001860 is_a: CCO:F0001229 ! complement receptor activity [Term] id: CCO:F0000235 name: complement component C4b receptor activity namespace: molecular_function def: "Combining with the C4b product of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0001861 is_a: CCO:F0000221 ! opsonin receptor activity is_a: CCO:F0000229 ! complement component C4b binding is_a: CCO:F0001229 ! complement receptor activity [Term] id: CCO:F0000236 name: collectin binding namespace: molecular_function def: "Interacting selectively with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). xref: GO:0001862 is_a: CCO:F0000220 ! opsonin binding [Term] id: CCO:F0000237 name: collectin receptor activity namespace: molecular_function def: "Combining with a collectin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). xref: GO:0001863 is_a: CCO:F0000221 ! opsonin receptor activity [Term] id: CCO:F0000238 name: pentraxin binding namespace: molecular_function def: "Interacting selectively with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). xref: GO:0001864 is_a: CCO:F0000220 ! opsonin binding [Term] id: CCO:F0000239 name: pattern binding namespace: molecular_function def: "Interacting selectively with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544] comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead. subset: goslim_pir subset: gosubset_prok synonym: "pattern recognition activity" BROAD [] xref: GO:0001871 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0000240 name: zymosan binding namespace: molecular_function def: "Interacting selectively with zymosan." [PMID:14707091] xref: GO:0001872 is_a: CCO:F0004357 ! polysaccharide binding [Term] id: CCO:F0000241 name: polysaccharide receptor activity namespace: molecular_function def: "Combining with a polysaccharide to initiate a change in cell activity." [PMID:14707091] xref: GO:0001873 is_a: CCO:F0001838 ! pattern recognition receptor activity is_a: CCO:F0004357 ! polysaccharide binding [Term] id: CCO:F0000242 name: zymosan receptor activity namespace: molecular_function def: "Combining with zymosan to initiate a change in cell activity." [PMID:14707091] xref: GO:0001874 is_a: CCO:F0000240 ! zymosan binding is_a: CCO:F0000241 ! polysaccharide receptor activity [Term] id: CCO:F0000243 name: lipopolysaccharide receptor activity namespace: molecular_function def: "Combining with lipopolysaccharide to initiate a change in cell activity." [PMID:14609719] synonym: "endotoxin receptor activity" BROAD [] synonym: "LPS receptor activity" EXACT [] xref: GO:0001875 is_a: CCO:F0000132 ! lipopolysaccharide binding is_a: CCO:F0001838 ! pattern recognition receptor activity [Term] id: CCO:F0000244 name: lipoarabinomannan binding namespace: molecular_function def: "Interacting selectively with lipoarabinomannan." [PMID:10586073] synonym: "LAM binding" EXACT [] xref: GO:0001876 is_a: CCO:F0000239 ! pattern binding [Term] id: CCO:F0000245 name: lipoarabinomannan receptor activity namespace: molecular_function def: "Combining with lipoarabinomannan to initiate a change in cell activity." [PMID:10586073] synonym: "LAM receptor activity" EXACT [] xref: GO:0001877 is_a: CCO:F0000244 ! lipoarabinomannan binding is_a: CCO:F0001838 ! pattern recognition receptor activity [Term] id: CCO:F0000246 name: nucleoside binding namespace: molecular_function def: "Interacting selectively with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd] subset: goslim_pir subset: gosubset_prok xref: GO:0001882 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0000247 name: purine nucleoside binding namespace: molecular_function def: "Interacting selectively with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd] xref: GO:0001883 is_a: CCO:F0000246 ! nucleoside binding [Term] id: CCO:F0000248 name: pyrimidine nucleoside binding namespace: molecular_function def: "Interacting selectively with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd] xref: GO:0001884 is_a: CCO:F0000246 ! nucleoside binding [Term] id: CCO:F0000249 name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223] synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223] synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] xref: EC:2.4.1.223 xref: GO:0001888 is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0000250 name: farnesylated protein binding namespace: molecular_function def: "Interacting selectively with a farnesylated protein." [GOC:add, PMID:14555765] xref: GO:0001918 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000251 name: glycoprotein binding namespace: molecular_function def: "Interacting selectively with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0001948 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000252 name: alpha-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:hjd, PMID:10854427] synonym: "isoglobotriaosylceramide synthase" NARROW [] xref: EC:2.4.1.- xref: GO:0001962 is_a: CCO:F0001853 ! galactosyltransferase activity [Term] id: CCO:F0000253 name: G-protein alpha-subunit binding namespace: molecular_function def: "Interacting selectively with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] synonym: "G-alpha protein subunit binding" EXACT [] xref: GO:0001965 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000254 name: fibronectin binding namespace: molecular_function def: "Interacting selectively with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] xref: GO:0001968 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000255 name: retinoic acid binding namespace: molecular_function def: "Interacting selectively with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd] xref: GO:0001972 is_a: CCO:F0001639 ! retinoid binding [Term] id: CCO:F0000256 name: protease binding namespace: molecular_function def: "Interacting selectively with any protease or peptidase." [GOC:hjd] xref: GO:0002020 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0000257 name: p53 binding namespace: molecular_function def: "Interacting selectively with one of the p53 family of proteins." [GOC:hjd] xref: GO:0002039 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000258 name: opsin binding namespace: molecular_function def: "Interacting selectively with an opsin, any of a group of hydrophbic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd] xref: GO:0002046 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0000259 name: nucleobase binding namespace: molecular_function def: "Interacting selectively with an nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd] subset: goslim_pir subset: gosubset_prok xref: GO:0002054 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0000260 name: adenine binding namespace: molecular_function def: "Interacting selectively with adenine, a purine base." [GOC:hjd] synonym: "6-aminopurine binding" EXACT [] xref: GO:0002055 is_a: CCO:F0000265 ! purine binding [Term] id: CCO:F0000261 name: cytosine binding namespace: molecular_function def: "Interactiing selectively with cytosine." [GOC:hjd] xref: GO:0002056 is_a: CCO:F0000266 ! pyrimidine binding [Term] id: CCO:F0000262 name: guanine binding namespace: molecular_function def: "Interacting selectively with guanine." [GOC:hjd] xref: GO:0002057 is_a: CCO:F0000265 ! purine binding [Term] id: CCO:F0000263 name: uracil binding namespace: molecular_function def: "Interacting selectively with uracil." [GOC:hjd] xref: GO:0002058 is_a: CCO:F0000266 ! pyrimidine binding [Term] id: CCO:F0000264 name: thymine binding namespace: molecular_function def: "Interacting selectively with thymine." [GOC:hjd] xref: GO:0002059 is_a: CCO:F0000266 ! pyrimidine binding [Term] id: CCO:F0000265 name: purine binding namespace: molecular_function def: "Interacting selectively with a purine, an organic nitrogenous base." [GOC:hjd] xref: GO:0002060 is_a: CCO:F0000259 ! nucleobase binding [Term] id: CCO:F0000266 name: pyrimidine binding namespace: molecular_function def: "Interacting selectively with a pyrimidine, an organic nitrogenous base." [GOC:hjd] synonym: "1,3-diazine binding" EXACT [] xref: GO:0002061 is_a: CCO:F0000259 ! nucleobase binding [Term] id: CCO:F0000267 name: 4-hydroxybenzoate decaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: decaprenyl-PP + p-hydroxybenzoate = decaprenyl-4-hydroxybenzoate + diphosphate." [GOC:hjd] xref: GO:0002083 is_a: CCO:F0000268 ! polyprenyltransferase activity [Term] id: CCO:F0000268 name: polyprenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd] subset: gosubset_prok xref: GO:0002094 is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0000269 name: interleukin-33 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-33 receptor." [GOC:hjd] xref: GO:0002112 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0000270 name: interleukin-33 binding namespace: molecular_function def: "Interacting selectively with interleukin-33." [GOC:hjd] xref: GO:0002113 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0000271 name: interleukin-33 receptor activity namespace: molecular_function def: "Combining with interleukin-33 to initiate a change in cell activity." [GOC:hjd] xref: GO:0002114 is_a: CCO:F0000270 ! interleukin-33 binding is_a: CCO:F0001254 ! interleukin receptor activity [Term] id: CCO:F0000272 name: molecular_function namespace: molecular_function def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "molecular function unknown" NARROW [] xref: GO:0003674 xref: GO:0005554 is_a: CCO:U0000001 ! biological continuant [Term] id: CCO:F0000273 name: nucleic acid binding namespace: molecular_function def: "Interacting selectively with any nucleic acid." [GOC:jl] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: GO:0003676 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0000274 name: DNA binding namespace: molecular_function def: "Interacting selectively with DNA (deoxyribonucleic acid)." [GOC:jl] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] xref: GO:0003677 is_a: CCO:F0000273 ! nucleic acid binding [Term] id: CCO:F0000275 name: DNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of a DNA duplex." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/] comment: Consider also annotating to the molecular function term 'DNA binding ; GO:0003677'. subset: gosubset_prok xref: GO:0003678 xref: GO:0003679 is_a: CCO:F0000803 ! helicase activity [Term] id: CCO:F0000276 name: AT DNA binding namespace: molecular_function def: "Interacting selectively with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, UniProtKB:P13483] synonym: "AT binding" EXACT [] xref: GO:0003680 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0000277 name: bent DNA binding namespace: molecular_function def: "Interacting selectively with DNA in a bent conformation." [GOC:jl, PMID:12627977] subset: gosubset_prok xref: GO:0003681 is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0000278 name: chromatin binding namespace: molecular_function def: "Interacting selectively with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "lamin/chromatin binding" BROAD [] synonym: "microtubule/chromatin interaction" RELATED [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] xref: GO:0003682 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0000279 name: damaged DNA binding namespace: molecular_function def: "Interacting selectively with damaged DNA." [GOC:jl] subset: gosubset_prok synonym: "DNA repair enzyme" RELATED [] synonym: "DNA repair protein" RELATED [] xref: GO:0003684 xref: Reactome:7372 is_a: CCO:F0000274 ! DNA binding [Term] id: CCO:F0000280 name: DNA replication origin binding namespace: molecular_function def: "Interacting selectively with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "ARS binding" NARROW [] xref: GO:0003688 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0000281 name: DNA clamp loader activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778] subset: gosubset_prok synonym: "DNA clamp loading ATPase activity" EXACT [] synonym: "PCNA loading activity" NARROW [] synonym: "PCNA loading complex activity" NARROW [] xref: GO:0003689 xref: Reactome:9823 is_a: CCO:F0000274 ! DNA binding is_a: CCO:F0005069 ! DNA-protein loading ATPase activity [Term] id: CCO:F0000282 name: double-stranded DNA binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA." [GOC:elh] subset: gosubset_prok xref: GO:0003690 is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0000283 name: double-stranded telomeric DNA binding namespace: molecular_function def: "Interacting selectively with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] xref: GO:0003691 is_a: CCO:F0000282 ! double-stranded DNA binding is_a: CCO:F0005630 ! telomeric DNA binding [Term] id: CCO:F0000284 name: left-handed Z-DNA binding namespace: molecular_function def: "Interacting selectively with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094] xref: GO:0003692 is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0000285 name: P-element binding namespace: molecular_function def: "Interacting selectively with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0003693 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0000286 name: random coil DNA binding namespace: molecular_function def: "Interacting selectively with DNA in a random coil configuration." [GOC:mah] synonym: "random coil binding" EXACT [] xref: GO:0003695 xref: GO:0016017 is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0000287 name: satellite DNA binding namespace: molecular_function def: "Interacting selectively with satellite DNA, DNA containing highly repetitive sequences which makes up a large proportion of the eukaryotic genome." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0003696 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0000288 name: single-stranded DNA binding namespace: molecular_function def: "Interacting selectively with single-stranded DNA." [GOC:elh] subset: gosubset_prok xref: GO:0003697 xref: GO:0003698 xref: GO:0003699 is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0000289 name: transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators] subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: GO:0000130 xref: GO:0003700 is_a: CCO:F0000274 ! DNA binding is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0000290 name: RNA polymerase I transcription factor activity namespace: molecular_function def: "Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl] xref: GO:0003701 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0000291 name: RNA polymerase II transcription factor activity namespace: molecular_function def: "Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl] xref: GO:0003702 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0000292 name: specific RNA polymerase II transcription factor activity namespace: molecular_function def: "Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma] xref: GO:0003704 is_a: CCO:F0000291 ! RNA polymerase II transcription factor activity [Term] id: CCO:F0000293 name: RNA polymerase II transcription factor activity, enhancer binding namespace: molecular_function def: "Functions to initiate or regulate RNA polymerase II transcription by binding an enhancer region of DNA." [GOC:jl] xref: GO:0003705 is_a: CCO:F0000289 ! transcription factor activity is_a: CCO:F0000291 ! RNA polymerase II transcription factor activity [Term] id: CCO:F0000294 name: ligand-regulated transcription factor activity namespace: molecular_function xref: GO:0003706 is_a: CCO:F0000292 ! specific RNA polymerase II transcription factor activity [Term] id: CCO:F0000295 name: steroid hormone receptor activity namespace: molecular_function def: "Combining with a steroid hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. xref: GO:0003707 is_a: CCO:F0001233 ! ligand-dependent nuclear receptor activity [Term] id: CCO:F0000296 name: retinoic acid receptor activity namespace: molecular_function def: "Combining with retinoic acid to initiate a change in cell activity. Retinoic acid is one of the forms of vitamin A." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. synonym: "vitamin A receptor activity" BROAD [] xref: GO:0003708 is_a: CCO:F0001233 ! ligand-dependent nuclear receptor activity [Term] id: CCO:F0000297 name: RNA polymerase III transcription factor activity namespace: molecular_function def: "Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl] xref: GO:0003709 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0000298 name: transcription elongation regulator activity namespace: molecular_function def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] subset: gosubset_prok synonym: "transcription elongation factor activity" EXACT [] synonym: "transcriptional elongation regulator activity" EXACT [] xref: GO:0003711 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0000299 name: transcription cofactor activity namespace: molecular_function def: "The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself." [PMID:10213677] subset: gosubset_prok synonym: "transcriptional co-regulator" EXACT [] synonym: "transcriptional cofactor activity" EXACT [] xref: GO:0003712 is_a: CCO:F0001738 ! transcription factor binding is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0000300 name: transcription coactivator activity namespace: molecular_function def: "The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself." [GOC:ma] subset: gosubset_prok synonym: "transcription co-activator activity" EXACT [] xref: GO:0003713 is_a: CCO:F0000299 ! transcription cofactor activity is_a: CCO:F0003205 ! transcription activator activity [Term] id: CCO:F0000301 name: transcription corepressor activity namespace: molecular_function def: "The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself." [GOC:ma] synonym: "transcription co-repressor activity" EXACT [] xref: GO:0003714 is_a: CCO:F0000299 ! transcription cofactor activity is_a: CCO:F0003206 ! transcription repressor activity [Term] id: CCO:F0000302 name: transcription termination factor activity namespace: molecular_function def: "Any activity that brings about termination of transcription." [GOC:mah] subset: gosubset_prok synonym: "transcriptional termination factor activity" EXACT [] xref: GO:0003715 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0000303 name: RNA polymerase I transcription termination factor activity namespace: molecular_function def: "Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah] synonym: "Pol I transcription termination factor activity" EXACT [] xref: GO:0003716 is_a: CCO:F0000302 ! transcription termination factor activity [Term] id: CCO:F0000304 name: RNA polymerase II transcription termination factor activity namespace: molecular_function def: "Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah] synonym: "Pol II transcription termination factor activity" EXACT [] xref: GO:0003717 is_a: CCO:F0000302 ! transcription termination factor activity [Term] id: CCO:F0000305 name: RNA polymerase III transcription termination factor activity namespace: molecular_function def: "Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah] synonym: "Pol III transcription termination factor activity" EXACT [] xref: GO:0003718 is_a: CCO:F0000302 ! transcription termination factor activity [Term] id: CCO:F0000306 name: telomerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc] comment: Consider also annotating to the molecular function term 'telomeric DNA binding ; GO:0042162'. xref: EC:2.7.7.- xref: GO:0003720 xref: Reactome:10567 is_a: CCO:F0000457 ! RNA-directed DNA polymerase activity [Term] id: CCO:F0000307 name: telomeric template RNA reverse transcriptase activity namespace: molecular_function def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242] synonym: "telomerase, catalyst" EXACT [] xref: GO:0003721 is_a: CCO:F0000457 ! RNA-directed DNA polymerase activity relationship: part_of CCO:F0000306 ! telomerase activity [Term] id: CCO:F0000308 name: RNA binding namespace: molecular_function def: "Interacting selectively with an RNA molecule or a portion thereof." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0003723 is_a: CCO:F0000273 ! nucleic acid binding [Term] id: CCO:F0000309 name: RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of an RNA helix." [GOC:jl] comment: Consider also annotating to the molecular function term 'RNA binding ; GO:0003723'. subset: gosubset_prok xref: EC:2.7.7.- xref: GO:0003724 xref: Reactome:7008 is_a: CCO:F0000803 ! helicase activity [Term] id: CCO:F0000310 name: double-stranded RNA binding namespace: molecular_function def: "Interacting selectively with double-stranded RNA." [GOC:jl] subset: gosubset_prok xref: GO:0003725 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0000311 name: double-stranded RNA adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah] subset: gosubset_prok synonym: "double-stranded RNA specific editase activity" RELATED [] xref: GO:0003726 xref: GO:0003971 xref: Reactome:10576 is_a: CCO:F0000485 ! adenosine deaminase activity [Term] id: CCO:F0000312 name: single-stranded RNA binding namespace: molecular_function def: "Interacting selectively with single-stranded RNA." [GOC:jl] xref: GO:0003727 xref: GO:0003728 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0000313 name: mRNA binding namespace: molecular_function def: "Interacting selectively with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA)." [GOC:jl] subset: gosubset_prok xref: GO:0003729 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0000314 name: mRNA 3'-UTR binding namespace: molecular_function def: "Interacting selectively with the 3' untranslated region of an mRNA molecule." [GOC:mah] synonym: "mRNA 3' UTR binding" EXACT [] xref: GO:0003730 is_a: CCO:F0000313 ! mRNA binding [Term] id: CCO:F0000315 name: structural constituent of ribosome namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. subset: gosubset_prok synonym: "ribosomal protein" BROAD [] synonym: "ribosomal RNA" RELATED [] xref: GO:0003735 xref: GO:0003736 xref: GO:0003737 xref: GO:0003738 xref: GO:0003739 xref: GO:0003740 xref: GO:0003741 xref: GO:0003742 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0000316 name: translation initiation factor activity namespace: molecular_function def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0003743 xref: GO:0003744 xref: GO:0003745 xref: Reactome:10611 is_a: CCO:F0001739 ! translation factor activity, nucleic acid binding [Term] id: CCO:F0000317 name: translation elongation factor activity namespace: molecular_function def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0003746 xref: GO:0008182 xref: GO:0008183 xref: Reactome:10616 is_a: CCO:F0001739 ! translation factor activity, nucleic acid binding [Term] id: CCO:F0000318 name: translation release factor activity namespace: molecular_function def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] subset: gosubset_prok xref: GO:0003747 xref: GO:0003748 xref: GO:0003749 is_a: CCO:F0001699 ! translation termination factor activity [Term] id: CCO:F0000319 name: peptidyl-prolyl cis-trans isomerase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] subset: gosubset_prok synonym: "cis-trans proline isomerase activity" EXACT [] synonym: "cyclophilin activity" RELATED [EC:5.2.1.8] synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW [] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW [] synonym: "immunophilin" RELATED [] synonym: "parvulin" RELATED [] synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidyl-prolyl isomerase B reaction" RELATED [] synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8] synonym: "PPIase activity" EXACT [EC:5.2.1.8] synonym: "rotamase activity" EXACT [EC:5.2.1.8] xref: EC:5.2.1.8 xref: GO:0003755 xref: GO:0004752 xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0000320 name: protein disulfide isomerase activity namespace: molecular_function def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1] subset: gosubset_prok synonym: "protein cysteine-thiol oxidation" RELATED [] synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1] synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1] synonym: "protein disulphide isomerase activity" EXACT [] synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1] xref: EC:5.3.4.1 xref: GO:0003756 xref: MetaCyc:5.3.4.1-RXN xref: MetaCyc:DISULISOM-RXN is_a: CCO:F0003424 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups is_a: CCO:F0003426 ! intramolecular oxidoreductase activity, transposing S-S bonds [Term] id: CCO:F0000321 name: motor activity namespace: molecular_function def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0003774 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0000322 name: microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. synonym: "axonemal motor activity" NARROW [] synonym: "dynein" BROAD [] synonym: "dynein ATPase activity" NARROW [] synonym: "kinesin" BROAD [] synonym: "kinesin motor activity" NARROW [] synonym: "kinetochore motor activity" NARROW [] xref: GO:0003777 is_a: CCO:F0000321 ! motor activity [Term] id: CCO:F0000323 name: actin binding namespace: molecular_function def: "Interacting selectively with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] subset: goslim_generic synonym: "membrane associated actin binding" NARROW [] xref: GO:0003779 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0000324 name: actin monomer binding namespace: molecular_function def: "Interacting selectively with monomeric actin, also known as G-actin." [GOC:ai] synonym: "G actin binding" EXACT [] xref: GO:0003785 is_a: CCO:F0000323 ! actin binding [Term] id: CCO:F0000325 name: actin lateral binding namespace: molecular_function def: "Interacting selectively with an actin filament along its length." [GOC:mah] xref: GO:0003786 is_a: CCO:F0008035 ! actin filament binding [Term] id: CCO:F0000326 name: lysozyme activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] subset: gosubset_prok synonym: "1,4-N-acetylmuramidase activity" EXACT [] synonym: "globulin G" RELATED [EC:3.2.1.17] synonym: "globulin G1" RELATED [EC:3.2.1.17] synonym: "L-7001" RELATED [EC:3.2.1.17] synonym: "lysozyme g" RELATED [EC:3.2.1.17] synonym: "mucopeptide glucohydrolase activity" EXACT [] synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT [] synonym: "muramidase activity" EXACT [] synonym: "N,O-diacetylmuramidase activity" EXACT [] synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17] synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17] xref: EC:3.2.1.17 xref: GO:0003796 xref: MetaCyc:3.2.1.17-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0000327 name: coagulation factor VIIa activity namespace: molecular_function def: "Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253] synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21] synonym: "blood coagulation factor VII activity" EXACT [] synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21] xref: EC:3.4.21.21 xref: GO:0003802 xref: MetaCyc:3.4.21.21-RXN xref: Reactome:11520 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000328 name: coagulation factor IXa activity namespace: molecular_function def: "Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22] synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22] synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22] synonym: "activated christmas factor" RELATED [EC:3.4.21.22] synonym: "autoprothrombin II" RELATED [EC:3.4.21.22] synonym: "blood coagulation factor IX activity" EXACT [] synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22] synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22] synonym: "Christmas factor activity" EXACT [EC:3.4.21.22] xref: EC:3.4.21.22 xref: GO:0003803 xref: MetaCyc:3.4.21.22-RXN xref: Reactome:11522 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000329 name: coagulation factor Xa activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023] synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6] synonym: "activated factor X" RELATED [EC:3.4.21.6] synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6] synonym: "autoprothrombin C" RELATED [EC:3.4.21.6] synonym: "blood coagulation factor X activity" EXACT [] synonym: "factor Xa" RELATED [EC:3.4.21.6] synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6] synonym: "prothrombase activity" EXACT [EC:3.4.21.6] synonym: "prothrombinase activity" EXACT [EC:3.4.21.6] synonym: "Stuart factor" RELATED [EC:3.4.21.6] synonym: "Stuart factor activity" EXACT [EC:3.4.21.6] synonym: "thrombokinase activity" EXACT [EC:3.4.21.6] synonym: "thromboplastin" RELATED [EC:3.4.21.6] xref: EC:3.4.21.6 xref: GO:0003804 xref: MetaCyc:3.4.21.6-RXN xref: Reactome:11523 is_a: CCO:F0000698 ! serine-type endopeptidase activity is_a: CCO:F0004479 ! prothrombin activator activity [Term] id: CCO:F0000330 name: coagulation factor XIa activity namespace: molecular_function def: "Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27] synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27] synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27] synonym: "blood coagulation factor XI activity" EXACT [] synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27] synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27] xref: EC:3.4.21.27 xref: GO:0003805 xref: MetaCyc:3.4.21.27-RXN xref: Reactome:11530 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000331 name: coagulation factor XIIa activity namespace: molecular_function def: "Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38] synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38] synonym: "blood coagulation factor XII activity" EXACT [] synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38] synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38] synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38] synonym: "hageman factor activity" EXACT [EC:3.4.21.38] synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38] synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38] synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38] synonym: "prealbumin activator" RELATED [EC:3.4.21.38] synonym: "prekallikrein activator" RELATED [EC:3.4.21.38] xref: EC:3.4.21.38 xref: GO:0003806 xref: MetaCyc:3.4.21.38-RXN xref: Reactome:11532 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000332 name: plasma kallikrein activity namespace: molecular_function def: "Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34] synonym: "bradykininogenase" BROAD [EC:3.4.21.34] synonym: "callicrein" RELATED [EC:3.4.21.34] synonym: "depot-padutin" RELATED [EC:3.4.21.34] synonym: "dilminal D" RELATED [EC:3.4.21.34] synonym: "glumorin" RELATED [EC:3.4.21.34] synonym: "kallidinogenase" BROAD [EC:3.4.21.34] synonym: "kallikrein" RELATED [EC:3.4.21.34] synonym: "kallikrein I" RELATED [EC:3.4.21.34] synonym: "kallikrein II" RELATED [EC:3.4.21.34] synonym: "kininogenase" BROAD [EC:3.4.21.34] synonym: "kininogenin activity" RELATED [EC:3.4.21.34] synonym: "onokrein P" RELATED [EC:3.4.21.34] synonym: "padreatin" RELATED [EC:3.4.21.34] synonym: "padutin" RELATED [EC:3.4.21.34] synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34] synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34] synonym: "urinary kallikrein" RELATED [EC:3.4.21.34] synonym: "urokallikrein" RELATED [EC:3.4.21.34] xref: EC:3.4.21.34 xref: GO:0003807 xref: MetaCyc:3.4.21.34-RXN xref: Reactome:11535 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000333 name: protein C (activated) activity namespace: molecular_function def: "Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69] synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69] synonym: "activated protein C" RELATED [EC:3.4.21.69] synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69] synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69] synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69] synonym: "GSAPC" RELATED [EC:3.4.21.69] synonym: "protein Ca" RELATED [EC:3.4.21.69] xref: EC:3.4.21.69 xref: GO:0003808 xref: MetaCyc:3.4.21.69-RXN xref: Reactome:11537 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000334 name: thrombin activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5] synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5] synonym: "beta-thrombin" RELATED [EC:3.4.21.5] synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5] synonym: "E thrombin" RELATED [EC:3.4.21.5] synonym: "factor IIa" RELATED [EC:3.4.21.5] synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5] synonym: "gamma-thrombin" RELATED [EC:3.4.21.5] synonym: "thrombase activity" EXACT [EC:3.4.21.5] synonym: "thrombin-C" RELATED [EC:3.4.21.5] synonym: "thrombofort" RELATED [EC:3.4.21.5] synonym: "topical" RELATED [EC:3.4.21.5] synonym: "tropostasin" RELATED [EC:3.4.21.5] xref: EC:3.4.21.5 xref: GO:0003809 xref: MetaCyc:3.4.21.5-RXN xref: Reactome:11540 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000335 name: protein-glutamine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] subset: gosubset_prok synonym: "factor XIIIa" RELATED [EC:2.3.2.13] synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13] synonym: "fibrinoligase activity" EXACT [] synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13] synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13] synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13] synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13] synonym: "TGase activity" EXACT [] synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13] synonym: "transglutaminase activity" EXACT [] xref: EC:2.3.2.13 xref: GO:0003810 xref: MetaCyc:2.3.2.13-RXN xref: Reactome:11549 xref: RESID:AA0124 is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0000336 name: alternative-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47] synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47] synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47] synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47] synonym: "C3 convertase activity" BROAD [EC:3.4.21.47] synonym: "C3 proactivator" RELATED [EC:3.4.21.47] synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47] synonym: "C5 convertase activity" BROAD [EC:3.4.21.47] synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47] synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47] synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47] synonym: "complement factor B activity" EXACT [EC:3.4.21.47] synonym: "CVF,Bb" RELATED [EC:3.4.21.47] synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47] synonym: "heat-labile factor" RELATED [EC:3.4.21.47] synonym: "proenzyme factor B" EXACT [] synonym: "properdin factor B activity" EXACT [EC:3.4.21.47] xref: EC:3.4.21.47 xref: GO:0003812 xref: MetaCyc:3.4.21.47-RXN xref: Reactome:11550 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000337 name: classical-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43] synonym: "C3 convertase activity" BROAD [EC:3.4.21.43] synonym: "C42" RELATED [EC:3.4.21.43] synonym: "C423" RELATED [EC:3.4.21.43] synonym: "C4b,2a" RELATED [EC:3.4.21.43] synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43] synonym: "C5 convertase activity" BROAD [EC:3.4.21.43] synonym: "complement C2 activity" BROAD [EC:3.4.21.43] synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43] synonym: "complement C42" RELATED [EC:3.4.21.43] xref: EC:3.4.21.43 xref: GO:0003813 xref: MetaCyc:3.4.21.43-RXN xref: Reactome:11551 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000338 name: complement component C1r activity namespace: molecular_function def: "Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41] synonym: "activated complement C1r" RELATED [EC:3.4.21.41] synonym: "C1r esterase activity" EXACT [EC:3.4.21.41] synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41] xref: EC:3.4.21.41 xref: GO:0003815 xref: MetaCyc:3.4.21.41-RXN xref: Reactome:11553 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000339 name: complement component C1s activity namespace: molecular_function def: "Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42] synonym: "activated complement C1s" RELATED [EC:3.4.21.42] synonym: "C1 esterase activity" EXACT [EC:3.4.21.42] synonym: "C1s esterase activity" EXACT [EC:3.4.21.42] synonym: "complement C1s" RELATED [EC:3.4.21.42] synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42] xref: EC:3.4.21.42 xref: GO:0003816 xref: MetaCyc:3.4.21.42-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000340 name: complement factor D activity namespace: molecular_function def: "Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46] synonym: "adipsin" EXACT [] synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46] synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46] synonym: "factor D" RELATED [EC:3.4.21.46] synonym: "factor D (complement)" RELATED [EC:3.4.21.46] synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46] xref: EC:3.4.21.46 xref: GO:0003817 xref: MetaCyc:3.4.21.46-RXN xref: Reactome:11557 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000341 name: complement factor I activity namespace: molecular_function def: "Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45] synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45] synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45] synonym: "C3bINA" RELATED [EC:3.4.21.45] synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4bi" RELATED [EC:3.4.21.45] synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45] synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45] synonym: "factor I" RELATED [EC:3.4.21.45] xref: EC:3.4.21.45 xref: GO:0003818 xref: MetaCyc:3.4.21.45-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000342 name: antigen binding namespace: molecular_function def: "Interacting selectively with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: goslim_pir synonym: "antibody" RELATED [] synonym: "B cell receptor activity" RELATED [] synonym: "immunoglobulin" RELATED [] synonym: "opsonin activity" RELATED [] xref: GO:0003823 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0000343 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "enzyme activity" RELATED [] xref: GO:0003824 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0000344 name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate." [EC:2.4.1.15] subset: gosubset_prok synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15] synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15] synonym: "transglucosylase activity" EXACT [] synonym: "trehalose 6-phosphate synthase activity" EXACT [] synonym: "trehalose 6-phosphate synthetase activity" EXACT [] synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-phosphate synthase activity" EXACT [] synonym: "trehalose-phosphate synthetase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [] synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] xref: EC:2.4.1.15 xref: GO:0003825 xref: MetaCyc:TREHALOSE6PSYN-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0000345 name: alpha-ketoacid dehydrogenase activity namespace: molecular_function subset: gosubset_prok xref: GO:0003826 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0000346 name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2 = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2." [EC:2.4.1.101] synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTI" RELATED [EC:2.4.1.101] synonym: "GNTI activity" EXACT [EC:2.4.1.101] synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] xref: EC:2.4.1.101 xref: GO:0003827 xref: MetaCyc:2.4.1.101-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0000347 name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R." [EC:2.4.99.8] synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8] synonym: "CMP-NeuAc:LM1(alpha2-8) sialyltranferase activity" EXACT [EC:2.4.99.8] synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8] synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "SAT-2" RELATED [EC:2.4.99.8] xref: EC:2.4.99.8 xref: GO:0003828 xref: MetaCyc:2.4.99.8-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0000348 name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102] synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] xref: EC:2.4.1.102 xref: GO:0003829 xref: MetaCyc:2.4.1.102-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0000349 name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] subset: gosubset_prok synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "GnTIII activity" EXACT [EC:2.4.1.144] synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144] xref: EC:2.4.1.144 xref: GO:0003830 xref: MetaCyc:2.4.1.144-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0000350 name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38] synonym: "beta-N-acetyl-beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "GalT activity" RELATED [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38] synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38] synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] xref: EC:2.4.1.38 xref: GO:0003831 xref: MetaCyc:2.4.1.38-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0000351 name: beta-alanyl-dopamine hydrolase activity namespace: molecular_function def: "Catalysis of the conversion of beta-alanyl dopamine to dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543] synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT [] synonym: "NBAD hydrolase activity" EXACT [] xref: GO:0003832 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0000352 name: beta-alanyl-dopamine synthase activity namespace: molecular_function def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543] synonym: "N-beta-alanyl dopamine synthetase activity" EXACT [] synonym: "NBAD transferase activity" EXACT [] xref: GO:0003833 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0000353 name: beta-carotene 15,15'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O2 = 2 retinal." [EC:1.14.99.36] comment: Note that this function was formerly EC:1.13.11.21. synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT [] synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36] synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36] synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36] xref: EC:1.14.99.36 xref: GO:0003834 xref: MetaCyc:BETA-CAROTENE-15 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0000354 name: beta-galactoside alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1] synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1] xref: EC:2.4.99.1 xref: GO:0003835 xref: MetaCyc:2.4.99.1-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0000355 name: beta-galactoside alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4] xref: EC:2.4.99.4 xref: GO:0003836 xref: MetaCyc:2.4.99.4-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0000356 name: beta-ureidopropionase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6] subset: gosubset_prok synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6] xref: EC:3.5.1.6 xref: GO:0003837 xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN xref: Reactome:11609 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000357 name: sterol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41] subset: gosubset_prok synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-sterol C-methyltransferase activity" EXACT [] synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "SMT1 activity" NARROW [EC:2.1.1.41] synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41] xref: EC:2.1.1.41 xref: GO:0003838 xref: MetaCyc:RXN3O-178 is_a: CCO:F0001756 ! C-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0000358 name: gamma-glutamylcyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4] synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.4] synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [EC:2.3.2.4] synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [EC:2.3.2.4] synonym: "L-glutamic cyclase activity" EXACT [EC:2.3.2.4] xref: EC:2.3.2.4 xref: GO:0003839 xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0000359 name: gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] subset: gosubset_prok synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-GPT" RELATED [EC:2.3.2.2] synonym: "gamma-GT" RELATED [EC:2.3.2.2] synonym: "gamma-GTP" RELATED [EC:2.3.2.2] synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2] xref: EC:2.3.2.2 xref: GO:0003840 xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0000360 name: 1-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate." [EC:2.3.1.51] subset: gosubset_prok synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "lysophosphatidate acyltransferase activity" EXACT [] synonym: "lysophosphatidic acid-acyltransferase activity" EXACT [EC:2.3.1.51] xref: EC:2.3.1.51 xref: GO:0003841 xref: GO:0004469 xref: MetaCyc:RXN-1623 is_a: CCO:F0003134 ! acylglycerol O-acyltransferase activity [Term] id: CCO:F0000361 name: 1-pyrroline-5-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H+." [EC:1.5.1.12] subset: gosubset_prok synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12] synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12] xref: EC:1.5.1.12 xref: GO:0003842 xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN xref: Reactome:11630 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000362 name: 1,3-beta-glucan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1)." [EC:2.4.1.34] synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "beta-1,3-glucan synthase activity" EXACT [] synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "callose synthase activity" EXACT [] synonym: "callose synthetase activity" EXACT [EC:2.4.1.34] synonym: "GS-II" RELATED [EC:2.4.1.34] synonym: "paramylon synthetase" RELATED [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] xref: EC:2.4.1.34 xref: GO:0003843 xref: GO:0009981 xref: MetaCyc:1 is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0000363 name: 1,4-alpha-glucan branching enzyme activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT [] synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT [] synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18] synonym: "branching enzyme activity" RELATED [EC:2.4.1.18] synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18] synonym: "enzyme Q" RELATED [EC:2.4.1.18] synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18] synonym: "plant branching enzyme" RELATED [EC:2.4.1.18] synonym: "Q-enzyme" RELATED [EC:2.4.1.18] synonym: "starch branching enzyme" RELATED [EC:2.4.1.18] xref: EC:2.4.1.18 xref: GO:0003844 xref: MetaCyc:GLYCOGEN-BRANCH-RXN xref: Reactome:11632 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0000364 name: 11-beta-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+." [EC:1.1.1.146, PMID:15761036] subset: gosubset_prok synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146] synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146] synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146] xref: GO:0003845 is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000365 name: 2-acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22] synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] xref: EC:2.3.1.22 xref: GO:0003846 xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN is_a: CCO:F0003134 ! acylglycerol O-acyltransferase activity [Term] id: CCO:F0000366 name: 1-alkyl-2-acetylglycerophosphocholine esterase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] subset: gosubset_prok synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] xref: EC:3.1.1.47 xref: GO:0003847 xref: MetaCyc:3.1.1.47-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0000367 name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine." [EC:2.7.6.3] subset: gosubset_prok synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3] synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "HPPK" RELATED [EC:2.7.6.3] synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3] xref: EC:2.7.6.3 xref: GO:0003848 xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003350 ! diphosphotransferase activity [Term] id: CCO:F0000368 name: 3-deoxy-7-phosphoheptulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate." [EC:2.5.1.54] comment: Note that this function was formerly EC:4.1.2.15. subset: gosubset_prok synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54] synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54] synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54] synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54] synonym: "DS-Co activity" RELATED [EC:2.5.1.54] synonym: "DS-Mn activity" RELATED [EC:2.5.1.54] synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54] synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54] xref: EC:2.5.1.54 xref: GO:0003849 xref: MetaCyc:DAHPSYN-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0000369 name: 2-deoxyglucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68] synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68] synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68] xref: EC:3.1.3.68 xref: GO:0003850 xref: MetaCyc:3.1.3.68-RXN is_a: CCO:F0004126 ! carbohydrate phosphatase activity [Term] id: CCO:F0000370 name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] xref: EC:2.4.1.45 xref: GO:0003851 xref: MetaCyc:2.4.1.45-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0000371 name: 2-isopropylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA." [EC:2.3.3.13] comment: Note that this function was formerly EC:4.1.3.12. subset: gosubset_prok synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13] synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13] synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] xref: EC:2.3.3.13 xref: GO:0003852 xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0000372 name: 2-methylacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12] synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12] xref: EC:1.3.99.12 xref: GO:0003853 xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN is_a: CCO:F0000480 ! acyl-CoA dehydrogenase activity [Term] id: CCO:F0000373 name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxy-delta(5)-steroid + NAD+ = 3-oxo-delta(5)-steroid + NADH + H+." [EC:1.1.1.145] subset: gosubset_prok synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT [] synonym: "3beta-HSDH" RELATED [EC:1.1.1.145] synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145] synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145] xref: EC:1.1.1.145 xref: GO:0003854 xref: MetaCyc:1.1.1.145-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000374 name: 3-dehydroquinate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O." [EC:4.2.1.10] subset: gosubset_prok synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "DHQase" EXACT [EC:4.2.1.10] xref: EC:4.2.1.10 xref: GO:0003855 xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000375 name: 3-dehydroquinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-deoxy-arabino-heptulosonate 7-phosphate = 3-dehydroquinate + phosphate." [EC:4.2.3.4] subset: gosubset_prok synonym: "3-dehydroquinate synthetase activity" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming)" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] synonym: "5-dehydroquinate synthase activity" EXACT [EC:4.2.3.4] synonym: "5-dehydroquinic acid synthetase activity" EXACT [EC:4.2.3.4] synonym: "dehydroquinate synthase activity" EXACT [EC:4.2.3.4] xref: EC:4.2.3.4 xref: GO:0003856 xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0000376 name: 3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." [EC:1.1.1.35] comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'. subset: gosubset_prok synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35] synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] xref: EC:1.1.1.35 xref: GO:0003857 xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN xref: Reactome:11645 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000377 name: 3-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+." [EC:1.1.1.30] subset: gosubset_prok synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30] xref: EC:1.1.1.30 xref: GO:0003858 xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN xref: Reactome:11646 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000378 name: 3-hydroxybutyryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O." [EC:4.2.1.55] subset: gosubset_prok synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55] synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55] synonym: "crotonase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55] xref: EC:4.2.1.55 xref: GO:0003859 xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000379 name: 3-hydroxyisobutyryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4] subset: gosubset_prok synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4] xref: EC:3.1.2.4 xref: GO:0003860 xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN xref: Reactome:11660 is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0000380 name: 3-isopropylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O." [EC:4.2.1.33] subset: gosubset_prok synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33] synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33] synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33] synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33] synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] xref: EC:4.2.1.33 xref: GO:0003861 xref: MetaCyc:3-ISOPROPYLMALISOM-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000381 name: 3-isopropylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85] subset: gosubset_prok synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85] synonym: "IMDH activity" EXACT [EC:1.1.1.85] synonym: "IPMDH" RELATED [EC:1.1.1.85] synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] xref: EC:1.1.1.85 xref: GO:0003862 xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000382 name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4] subset: gosubset_prok synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4] synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "BCKDH activity" RELATED [EC:1.2.4.4] synonym: "BCOAD activity" RELATED [EC:1.2.4.4] synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4] synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4] xref: EC:1.2.4.4 xref: GO:0003863 xref: MetaCyc:1.2.4.4-RXN xref: Reactome:11663 is_a: CCO:F0003226 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: CCO:F0000383 name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11] subset: gosubset_prok synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] xref: EC:2.1.2.11 xref: GO:0003864 xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN is_a: CCO:F0003318 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: CCO:F0000384 name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5] synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5] synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5] synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5] synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5] xref: EC:1.3.99.5 xref: GO:0003865 xref: MetaCyc:1.3.99.5-RXN is_a: CCO:F0005255 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: CCO:F0000385 name: 3-phosphoshikimate 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate." [EC:2.5.1.19] subset: gosubset_prok synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19] synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19] xref: EC:2.5.1.19 xref: GO:0003866 xref: MetaCyc:2.5.1.19-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0000386 name: 4-aminobutyrate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah] subset: gosubset_prok synonym: "4-aminobutanoate transaminase activity" EXACT [] synonym: "4-aminobutyrate aminotransferase activity" EXACT [] synonym: "4-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "aminobutyrate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "beta-alanine aminotransferase" RELATED [EC:2.6.1.19] synonym: "beta-alanine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] synonym: "beta-alanine-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19] synonym: "GABA aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA transaminase activity" EXACT [] synonym: "GABA transferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid transaminase activity" EXACT [] synonym: "gamma-aminobutyric transaminase activity" EXACT [EC:2.6.1.19] synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [EC:2.6.1.19] xref: EC:2.6.1.19 xref: GO:0003867 xref: MetaCyc:GABATRANSAM-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0000387 name: 4-hydroxyphenylpyruvate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27] subset: gosubset_prok synonym: "4-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate oxidase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic oxidase activity" EXACT [EC:1.13.11.27] xref: EC:1.13.11.27 xref: GO:0003868 xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN xref: Reactome:11670 xref: UM-BBD_enzymeID:e0126 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0000388 name: 4-nitrophenylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate." [EC:3.1.3.41] subset: gosubset_prok synonym: "4-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "K-pNPPase activity" EXACT [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "NPPase activity" EXACT [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" EXACT [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "PNPPase activity" EXACT [EC:3.1.3.41] xref: EC:3.1.3.41 xref: GO:0003869 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0000389 name: 5-aminolevulinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2." [EC:2.3.1.37] subset: gosubset_prok synonym: "5-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALAS activity" EXACT [EC:2.3.1.37] synonym: "alpha-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT [EC:2.3.1.37] xref: EC:2.3.1.37 xref: GO:0003870 xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN xref: Reactome:11690 is_a: CCO:F0003324 ! N-succinyltransferase activity [Term] id: CCO:F0000390 name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine." [EC:2.1.1.14] subset: gosubset_prok synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "cobalamin-independent methionine synthase activity" EXACT [EC:2.1.1.14] synonym: "homocysteine methylase activity" EXACT [EC:2.1.1.14] synonym: "MetE" RELATED [EC:2.1.1.14] synonym: "methionine synthase (cobalamin-independent) activity" EXACT [EC:2.1.1.14] synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroyltriglutamate methyltransferase activity" EXACT [EC:2.1.1.14] xref: EC:2.1.1.14 xref: GO:0003871 xref: MetaCyc:HOMOCYSMET-RXN is_a: CCO:F0001759 ! S-methyltransferase activity is_a: CCO:F0005621 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity [Term] id: CCO:F0000391 name: 6-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11] subset: gosubset_prok synonym: "6-phosphofructokinase reduction" EXACT [] synonym: "6-phosphofructose 1-kinase activity" EXACT [EC:2.7.1.11] synonym: "ATP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphate kinase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphokinase activity" EXACT [EC:2.7.1.11] synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "PFK" RELATED [EC:2.7.1.11] synonym: "phospho-1,6-fructokinase activity" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase I activity" EXACT [EC:2.7.1.11] synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11] xref: EC:2.7.1.11 xref: GO:0003872 xref: MetaCyc:6PFRUCTPHOS-RXN xref: Reactome:11692 is_a: CCO:F0001906 ! phosphofructokinase activity [Term] id: CCO:F0000392 name: 6-phosphofructo-2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate." [EC:2.7.1.105] synonym: "6-phosphofructo-2-kinase (phosphorylating)" EXACT [EC:2.7.1.105] synonym: "6-phosphofructose 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "fructose 6-phosphate 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "phosphofructokinase 2 activity" EXACT [EC:2.7.1.105] xref: EC:2.7.1.105 xref: GO:0003873 xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN xref: Reactome:11695 is_a: CCO:F0001906 ! phosphofructokinase activity [Term] id: CCO:F0000393 name: 6-pyruvoyltetrahydropterin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate." [EC:4.2.3.12] subset: gosubset_prok synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" EXACT [EC:4.2.3.12] synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" EXACT [EC:4.2.3.12] synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" EXACT [EC:4.2.3.12] synonym: "PTPS activity" EXACT [EC:4.2.3.12] xref: EC:4.2.3.12 xref: GO:0003874 xref: MetaCyc:4.2.3.12-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0000394 name: ADP-ribosylarginine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19] subset: gosubset_prok synonym: "ADP-ribose-L-arginine cleavage enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADP-ribose-L-arginine cleaving enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADPribosylarginine hydrolase activity" EXACT [] synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein ADP-ribosylarginine hydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] xref: EC:3.2.2.19 xref: GO:0003875 xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0000395 name: AMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] synonym: "5-adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-AMP deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-phosphate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenosine monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenyl deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase reaction" EXACT [] synonym: "adenylate desaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic deaminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6] xref: EC:3.5.4.6 xref: GO:0003876 xref: MetaCyc:AMP-DEAMINASE-RXN xref: Reactome:11698 is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0000396 name: ATP adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53] subset: gosubset_prok synonym: "adenine triphosphate adenylyltransferase activity" EXACT [EC:2.7.7.53] synonym: "ADP:ATP adenylyltransferase activity" EXACT [] synonym: "AP-4-A phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] xref: EC:2.7.7.53 xref: GO:0003877 xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000397 name: ATP citrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA." [EC:2.3.3.8] comment: Note that this function was formerly EC:4.1.3.8. synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8] synonym: "adenosine triphosphate citrate lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP citrate (pro-S)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citrate (pro-S)-lyase activity" EXACT [] synonym: "ATP-citrate (pro-S-)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citric lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8] synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8] synonym: "citrate-ATP lyase activity" EXACT [EC:2.3.3.8] synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8] xref: EC:2.3.3.8 xref: GO:0003878 xref: GO:0046913 xref: MetaCyc:ATP-CITRATE-(PRO-S-)-LYASE-RXN xref: MetaCyc:PWY-5172 is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0000398 name: ATP phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17] subset: gosubset_prok synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.17] synonym: "adenosine triphosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP diphosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] xref: EC:2.4.2.17 xref: GO:0003879 xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000399 name: C-terminal protein carboxyl methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carbon atom of the C-terminal residue of a protein." [PMID:8428937] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0003880 is_a: CCO:F0001813 ! protein methyltransferase activity [Term] id: CCO:F0000400 name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol." [EC:2.7.8.11] subset: gosubset_prok synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-DG:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "phosphatidylinositol synthase activity" EXACT [] xref: EC:2.7.8.11 xref: GO:0003881 xref: MetaCyc:2.7.8.11-RXN is_a: CCO:F0003607 ! CDP-alcohol phosphatidyltransferase activity [Term] id: CCO:F0000401 name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8] subset: gosubset_prok synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8] synonym: "PS synthase activity" EXACT [EC:2.7.8.8] synonym: "serine exchange enzyme" BROAD [] xref: EC:2.7.8.8 xref: GO:0003882 xref: MetaCyc:PHOSPHASERSYN-RXN is_a: CCO:F0003607 ! CDP-alcohol phosphatidyltransferase activity [Term] id: CCO:F0000402 name: CTP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] subset: gosubset_prok synonym: "CTP synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine 5'-triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "uridine triphosphate aminase activity" EXACT [EC:6.3.4.2] synonym: "UTP--ammonia ligase activity" EXACT [EC:6.3.4.2] synonym: "UTP:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.2] xref: EC:6.3.4.2 xref: GO:0003883 xref: MetaCyc:CTPSYN-RXN xref: Reactome:11718 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0000403 name: D-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2." [EC:1.4.3.3] subset: gosubset_prok synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.3] synonym: "L-amino acid:O2 oxidoreductase activity" EXACT [EC:1.4.3.3] synonym: "new yellow enzyme" RELATED [EC:1.4.3.3] xref: EC:1.4.3.3 xref: GO:0003884 xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0000404 name: D-arabinono-1,4-lactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = D-erythro-ascorbate + H2O2." [EC:1.1.3.37] subset: gosubset_prok synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" EXACT [EC:1.1.3.37] xref: EC:1.1.3.37 xref: GO:0003885 xref: MetaCyc:1.1.3.37-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0000405 name: DNA (cytosine-5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37] comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). subset: gosubset_prok synonym: "cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37] synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "cytosine-specific DNA methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA 5-cytosine methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C(5) methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine c5 methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C5 methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA-cytosine 5-methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37] synonym: "modification methylase activity" RELATED [EC:2.1.1.37] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37] synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [:] synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37] xref: EC:2.1.1.37 xref: GO:0003886 xref: GO:0008326 xref: MetaCyc:2.1.1.73-RXN xref: MetaCyc:DNA-(CYTOSINE-5-)-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity is_a: CCO:F0002339 ! DNA-methyltransferase activity [Term] id: CCO:F0000406 name: DNA-directed DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684] subset: gosubset_prok synonym: "alpha DNA polymerase activity" NARROW [] synonym: "beta DNA polymerase activity" NARROW [] synonym: "delta DNA polymerase activity" NARROW [] synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7] synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7] synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7] synonym: "DNA polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA polymerase II" NARROW [EC:2.7.7.7] synonym: "DNA polymerase III" NARROW [EC:2.7.7.7] synonym: "DNA polymerase V activity" NARROW [] synonym: "DNA replicase activity" EXACT [EC:2.7.7.7] synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7] synonym: "duplicase" BROAD [EC:2.7.7.7] synonym: "epsilon DNA polymerase activity" NARROW [] synonym: "eta DNA polymerase activity" NARROW [] synonym: "gamma DNA-directed DNA polymerase activity" NARROW [] synonym: "iota DNA polymerase activity" NARROW [] synonym: "kappa DNA polymerase activity" NARROW [] synonym: "Klenow fragment" NARROW [EC:2.7.7.7] synonym: "lambda DNA polymerase activity" NARROW [] synonym: "mu DNA polymerase activity" NARROW [] synonym: "nu DNA polymerase activity" NARROW [] synonym: "sequenase" RELATED [EC:2.7.7.7] synonym: "sigma DNA polymerase activity" NARROW [] synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7] synonym: "Taq Pol I" NARROW [EC:2.7.7.7] synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7] synonym: "theta DNA polymerase activity" NARROW [] synonym: "zeta DNA polymerase activity" NARROW [] xref: EC:2.7.7.- xref: EC:2.7.7.7 xref: GO:0003887 xref: GO:0003888 xref: GO:0003889 xref: GO:0003890 xref: GO:0003891 xref: GO:0003893 xref: GO:0003894 xref: GO:0003895 xref: GO:0008723 xref: GO:0015999 xref: GO:0016000 xref: GO:0016448 xref: GO:0016449 xref: GO:0016450 xref: GO:0016451 xref: GO:0016452 xref: GO:0019984 xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:11722 xref: Reactome:11738 xref: Reactome:26112 xref: Reactome:69114 is_a: CCO:F0005510 ! DNA polymerase activity [Term] id: CCO:F0000407 name: DNA primase activity namespace: molecular_function def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094] subset: gosubset_prok xref: EC:2.7.7.- xref: GO:0003896 xref: GO:0003897 xref: GO:0003898 is_a: CCO:F0000408 ! DNA-directed RNA polymerase activity [Term] id: CCO:F0000408 name: DNA-directed RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] subset: gosubset_prok synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-directed RNA polymerase I activity" NARROW [] synonym: "DNA-directed RNA polymerase II activity" NARROW [] synonym: "DNA-directed RNA polymerase III activity" NARROW [] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: EC:2.7.7.6 xref: GO:0000129 xref: GO:0003899 xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:11745 is_a: CCO:F0005511 ! RNA polymerase activity [Term] id: CCO:F0000409 name: deoxyribodipyrimidine photo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). The enzyme catalyzes the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme." [EC:4.1.99.3] comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. subset: gosubset_prok synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribodipyrimidine photolyase activity" EXACT [] synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic photolyase activity" EXACT [EC:4.1.99.3] synonym: "dipyrimidine photolyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "DNA cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3] synonym: "photolyase activity" EXACT [EC:4.1.99.3] synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3] synonym: "phr A photolyase activity" EXACT [EC:4.1.99.3] synonym: "PhrB photolyase activity" EXACT [EC:4.1.99.3] synonym: "PRE" RELATED [EC:4.1.99.3] xref: EC:4.1.99.3 xref: GO:0003904 xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: CCO:F0000417 ! DNA photolyase activity [Term] id: CCO:F0000410 name: alkylbase DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] subset: gosubset_prok synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21] synonym: "AlkA" RELATED [EC:3.2.2.21] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21] synonym: "alkylbase DNA glycosidase activity" EXACT [] synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21] synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21] synonym: "DNA-3-methyladenine glycosidase II activity" EXACT [] synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21] xref: EC:3.2.2.21 xref: GO:0003905 xref: GO:0004036 xref: MetaCyc:3.2.2.21-RXN is_a: CCO:F0004051 ! DNA N-glycosylase activity [Term] id: CCO:F0000411 name: DNA-(apurinic or apyrimidinic site) lyase activity namespace: molecular_function def: "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18] comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. subset: gosubset_prok synonym: "AP endonuclease class I activity" NARROW [EC:4.2.99.18] synonym: "AP lyase activity" EXACT [EC:4.2.99.18] synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] synonym: "E. coli endonuclease III" RELATED [EC:4.2.99.18] synonym: "E.coli endonuclease III activity" NARROW [EC:4.2.99.18] synonym: "endodeoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] synonym: "endonuclease VIII activity" RELATED [] synonym: "micrococcus luteus UV endonuclease" NARROW [EC:4.2.99.18] synonym: "Micrococcus luteus UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "Phage-T(4) UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "phage-T4 UV endonuclease" BROAD [EC:4.2.99.18] synonym: "Phage-T4 UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "X-ray endonuclease III" RELATED [EC:4.2.99.18] xref: EC:4.2.99.18 xref: GO:0003906 xref: MetaCyc:4.2.99.18-RXN xref: Reactome:12450 is_a: CCO:F0003401 ! carbon-oxygen lyase activity [Term] id: CCO:F0000412 name: methylated-DNA-[protein]-cysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. subset: gosubset_prok synonym: "6-O-methylguanine-DNA methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT [] synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "MGMT" EXACT [] synonym: "O-6-methylguanine-DNA-alkyltransferase activity" EXACT [EC:2.1.1.63] synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD [] xref: EC:2.1.1.63 xref: GO:0003908 xref: MetaCyc:2.1.1.63-RXN xref: Reactome:12455 is_a: CCO:F0001759 ! S-methyltransferase activity [Term] id: CCO:F0000413 name: DNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another; requires an energy source such as ATP or NAD+." [ISBN:0716720094] subset: gosubset_prok xref: EC:6.5.1.- xref: GO:0003909 xref: Reactome:12459 is_a: CCO:F0003444 ! ligase activity, forming phosphoric ester bonds [Term] id: CCO:F0000414 name: DNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1] subset: gosubset_prok synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1] synonym: "DNA joinase activity" BROAD [EC:6.5.1.1] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.1] synonym: "polydeoxyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1] synonym: "polynucleotide ligase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "sealase activity" RELATED [EC:6.5.1.1] xref: EC:6.5.1.1 xref: GO:0003910 xref: MetaCyc:DNA-LIGASE-(ATP)-RXN is_a: CCO:F0000413 ! DNA ligase activity [Term] id: CCO:F0000415 name: DNA ligase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2] subset: gosubset_prok synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2] synonym: "DNA joinase activity" BROAD [EC:6.5.1.2] synonym: "DNA ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" EXACT [EC:6.5.1.2] synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD)" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase activity" EXACT [EC:6.5.1.2] xref: EC:6.5.1.2 xref: GO:0003911 xref: MetaCyc:DNA-LIGASE-(NAD(+))-RXN is_a: CCO:F0000413 ! DNA ligase activity [Term] id: CCO:F0000416 name: DNA nucleotidylexotransferase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31] synonym: "addase activity" EXACT [EC:2.7.7.31] synonym: "deoxynucleotidyl terminal transferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic acid nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [EC:2.7.7.31] synonym: "TdT" RELATED [EC:2.7.7.31] synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31] synonym: "terminal deoxynucleotide transferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxynucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxyribonucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal transferase activity" EXACT [EC:2.7.7.31] xref: EC:2.7.7.31 xref: GO:0003912 xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000417 name: DNA photolyase activity namespace: molecular_function def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949] subset: gosubset_prok xref: EC:4.1.99.- xref: GO:0003913 is_a: CCO:F0003397 ! carbon-carbon lyase activity [Term] id: CCO:F0000418 name: DNA (6-4) photolyase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949] xref: GO:0003914 is_a: CCO:F0000417 ! DNA photolyase activity [Term] id: CCO:F0000419 name: DNA topoisomerase activity namespace: molecular_function def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] subset: gosubset_prok xref: EC:5.99.1.- xref: GO:0003916 xref: GO:0009387 is_a: CCO:F0000274 ! DNA binding is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0000420 name: DNA topoisomerase type I activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. subset: gosubset_prok synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.2] synonym: "DNA topoisomerase I activity" NARROW [] synonym: "nicking-closing enzyme activity" RELATED [EC:5.99.1.2] synonym: "omega-protein activity" RELATED [EC:5.99.1.2] synonym: "relaxing enzyme activity" RELATED [EC:5.99.1.2] synonym: "swivelase activity" RELATED [EC:5.99.1.2] synonym: "topoisomerase" BROAD [EC:5.99.1.2] synonym: "type I DNA topoisomerase activity" EXACT [] synonym: "type I topoisomerase activity" EXACT [] synonym: "untwisting enzyme activity" RELATED [EC:5.99.1.2] xref: EC:5.99.1.2 xref: GO:0003917 xref: MetaCyc:5.99.1.2-RXN is_a: CCO:F0000419 ! DNA topoisomerase activity [Term] id: CCO:F0000421 name: DNA topoisomerase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192] subset: gosubset_prok synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.3] synonym: "deoxyribonucleic topoisomerase activity" EXACT [EC:5.99.1.3] synonym: "DNA gyrase activity" NARROW [] synonym: "DNA topoisomerase (ATP-hydrolysing)" BROAD [EC:5.99.1.3] synonym: "DNA topoisomerase II" RELATED [EC:5.99.1.3] synonym: "DNA topoisomerase IV activity" EXACT [] synonym: "DNA topoisomerase type II activity" EXACT [] synonym: "DNA-gyrase activity" EXACT [EC:5.99.1.3] synonym: "topoisomerase" BROAD [EC:5.99.1.3] synonym: "topoisomerase II" EXACT [] synonym: "type II DNA topoisomerase activity" EXACT [EC:5.99.1.3] xref: EC:5.99.1.3 xref: GO:0003918 xref: MetaCyc:5.99.1.3-RXN is_a: CCO:F0000419 ! DNA topoisomerase activity [Term] id: CCO:F0000422 name: FMN adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2] subset: gosubset_prok synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "ATP:FMN adenylyltransferase activity" EXACT [] synonym: "FAD diphosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD synthetase activity" EXACT [EC:2.7.7.2] synonym: "flavin adenine dinucleotide synthetase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] xref: EC:2.7.7.2 xref: GO:0003919 xref: MetaCyc:FADSYN-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000423 name: GMP reductase activity namespace: molecular_function def: "Catalysis of the reaction: inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH + H+." [EC:1.7.1.7] comment: Note that this function was formerly EC:1.6.6.8. subset: gosubset_prok synonym: "guanosine 5'-monophosphate oxidoreductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-phosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7] synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" EXACT [EC:1.7.1.7] synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" EXACT [EC:1.7.1.7] synonym: "NADPH:GMP oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] xref: EC:1.7.1.7 xref: GO:0003920 xref: MetaCyc:GMP-REDUCT-RXN is_a: CCO:F0003255 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: CCO:F0000424 name: GMP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP." [EC:6.3.4.1] synonym: "guanylate synthetase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine 5'-monophosphate aminase activity" EXACT [EC:6.3.4.1] synonym: "Xanthosine-5'-phosphate--ammonia ligase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine-5'-phosphate-ammonia ligase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine-5'-phosphate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.4.1] synonym: "XMP aminase activity" EXACT [EC:6.3.4.1] xref: EC:6.3.4.1 xref: GO:0003921 xref: MetaCyc:GMP-SYN-NH3-RXN xref: Reactome:12506 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0000425 name: GMP synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2] subset: gosubset_prok synonym: "glutamine amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "GMP synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.2] synonym: "guanosine 5'-monophosphate synthetase activity" EXACT [EC:6.3.5.2] synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "guanylate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "xanthosine 5'-phosphate amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.2] xref: EC:6.3.5.2 xref: GO:0003922 xref: MetaCyc:GMP-SYN-GLUT-RXN is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0000426 name: GPI-anchor transamidase activity namespace: molecular_function def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309 "Biochemical Pathways"] xref: EC:3.-.-.- xref: GO:0003923 xref: Reactome:12511 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0000427 name: GTPase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] comment: Consider also annotating to the molecular function term 'GTP binding ; GO:0005525'. subset: gosubset_prok synonym: "ARF small monomeric GTPase activity" NARROW [] synonym: "dynamin GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] synonym: "protein-synthesizing GTPase activity" NARROW [] synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] synonym: "protein-synthesizing GTPase activity, termination" NARROW [] synonym: "Rab small monomeric GTPase activity" NARROW [] synonym: "Ran small monomeric GTPase activity" NARROW [] synonym: "Ras small monomeric GTPase activity" NARROW [] synonym: "RHEB small monomeric GTPase activity" NARROW [] synonym: "Rho small monomeric GTPase activity" NARROW [] synonym: "Sar small monomeric GTPase activity" NARROW [] synonym: "signal-recognition-particle GTPase activity" NARROW [] synonym: "small monomeric GTPase activity" NARROW [] synonym: "tubulin GTPase activity" NARROW [] xref: GO:0003924 xref: Reactome:12513 is_a: CCO:F0003574 ! nucleoside-triphosphatase activity [Term] id: CCO:F0000428 name: GTP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [GOC:jl, http://cancerweb.ncl.ac.uk] subset: gosubset_prok xref: EC:3.5.4.- xref: GO:0003933 is_a: CCO:F0004139 ! cyclohydrolase activity [Term] id: CCO:F0000429 name: GTP cyclohydrolase I activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [EC:3.5.4.16] subset: gosubset_prok synonym: "dihydroneopterin triphosphate synthase activity" EXACT [EC:3.5.4.16] synonym: "GTP 7,8-8,9-dihydrolase activity" EXACT [EC:3.5.4.16] synonym: "GTP 8-formylhydrolase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate 8-deformylase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate cyclohydrolase activity" EXACT [EC:3.5.4.16] xref: EC:3.5.4.16 xref: GO:0003934 xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN is_a: CCO:F0000428 ! GTP cyclohydrolase activity [Term] id: CCO:F0000430 name: GTP cyclohydrolase II activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate." [EC:3.5.4.25] subset: gosubset_prok synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" EXACT [EC:3.5.4.25] synonym: "GTP-8-formylhydrolase activity" EXACT [EC:3.5.4.25] synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25] xref: EC:3.5.4.25 xref: GO:0003935 xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN is_a: CCO:F0000428 ! GTP cyclohydrolase activity [Term] id: CCO:F0000431 name: IMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] subset: gosubset_prok synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10] synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10] synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10] synonym: "inosinicase activity" EXACT [EC:3.5.4.10] xref: EC:3.5.4.10 xref: GO:0003937 xref: MetaCyc:IMPCYCLOHYDROLASE-RXN xref: Reactome:12558 is_a: CCO:F0004139 ! cyclohydrolase activity [Term] id: CCO:F0000432 name: IMP dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] subset: gosubset_prok synonym: "IMP oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "IMP:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205] synonym: "inosine 5'-monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosine-5'-phosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205] xref: EC:1.1.1.205 xref: GO:0003938 xref: MetaCyc:IMP-DEHYDROG-RXN xref: Reactome:12563 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000433 name: L-iditol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] subset: gosubset_prok synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14] synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] xref: EC:1.1.1.14 xref: GO:0003939 xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000434 name: L-iduronidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in desulfated dermatan." [EC:3.2.1.76] synonym: "alpha-L-iduronidase activity" EXACT [EC:3.2.1.76] synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" EXACT [EC:3.2.1.76] xref: EC:3.2.1.76 xref: GO:0003940 xref: MetaCyc:3.2.1.76-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0000435 name: L-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17] comment: Note that this function was formerly EC:4.3.1.13. subset: gosubset_prok synonym: "L-hydroxyaminoacid dehydratase activity" BROAD [] synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17] synonym: "L-serine deaminase activity" EXACT [] synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17] synonym: "L-serine hydro-lyase (deaminating) activity" EXACT [] synonym: "serine deaminase activity" BROAD [EC:4.3.1.17] xref: EC:4.3.1.17 xref: GO:0003941 xref: MetaCyc:4.3.1.17-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0000436 name: N-acetyl-gamma-glutamyl-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38] subset: gosubset_prok synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38] synonym: "reductase, acetyl-gamma-glutamyl phosphate" EXACT [EC:1.2.1.38] xref: EC:1.2.1.38 xref: GO:0003942 xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000437 name: N-acetylgalactosamine-4-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] subset: gosubset_prok synonym: "acetylgalactosamine 4-sulfatase activity" EXACT [EC:3.1.6.12] synonym: "arylsulfatase B" EXACT [] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12] synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT [] xref: EC:3.1.6.12 xref: GO:0003943 xref: MetaCyc:3.1.6.12-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0000438 name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45] synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" EXACT [EC:3.1.4.45] synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" EXACT [EC:3.1.4.45] synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45] synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45] xref: EC:3.1.4.45 xref: GO:0003944 xref: MetaCyc:3.1.4.45-RXN is_a: CCO:F0003024 ! hexosaminidase activity [Term] id: CCO:F0000439 name: N-acetyllactosamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] subset: gosubset_prok synonym: "acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta-N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta1-4GalT" RELATED [EC:2.4.1.90] synonym: "Gal-T" RELATED [EC:2.4.1.90] synonym: "lactosamine synthase activity" EXACT [EC:2.4.1.90] synonym: "lactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90] synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetylglucosamine (beta1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "NAL synthetase activity" EXACT [EC:2.4.1.90] synonym: "UDP-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] xref: EC:2.4.1.90 xref: GO:0003945 xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0000441 name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-glucosaminylamine + L-aspartate." [EC:3.5.1.26] subset: gosubset_prok synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylamine deaspartylase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglycosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "beta-aspartylglucosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26] synonym: "glycosylasparaginase activity" EXACT [EC:3.5.1.26] synonym: "N-aspartyl-beta-glucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] xref: EC:3.5.1.26 xref: GO:0003948 xref: MetaCyc:3.5.1.26-RXN is_a: CCO:F0000542 ! asparaginase activity [Term] id: CCO:F0000442 name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide = N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide." [EC:5.3.1.16] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" EXACT [EC:5.3.1.16] synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] xref: EC:5.3.1.16 xref: GO:0003949 xref: MetaCyc:PRIBFAICARPISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0000443 name: NAD+ ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] subset: gosubset_prok synonym: "ADP-ribosyltransferase (polymerizing) activity" EXACT [EC:2.4.2.30] synonym: "NAD ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [EC:2.4.2.30] synonym: "poly(adenosine diphosphate ribose) polymerase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthetase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose)polymerase activity" EXACT [EC:2.4.2.30] xref: EC:2.4.2.30 xref: GO:0003950 xref: MetaCyc:NAD(+)-ADP-RIBOSYLTRANSFERASE-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000444 name: NAD+ kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NAD+ = ADP + NADP+." [EC:2.7.1.23] subset: gosubset_prok synonym: "ATP:NAD+ 2'-phosphotransferase activity" EXACT [EC:2.7.1.23] synonym: "DPN kinase activity" RELATED [EC:2.7.1.23] synonym: "NAD kinase activity" EXACT [] synonym: "NADK" RELATED [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase activity" EXACT [EC:2.7.1.23] xref: EC:2.7.1.23 xref: GO:0003951 xref: MetaCyc:NAD-KIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000445 name: NAD+ synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1] subset: gosubset_prok synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.1] synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" EXACT [EC:6.3.5.1] synonym: "DPN synthetase activity" EXACT [EC:6.3.5.1] synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "NAD synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.1] synonym: "NAD+ synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD+ synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.1] synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" EXACT [EC:6.3.5.1] xref: EC:6.3.5.1 xref: GO:0003952 xref: MetaCyc:NAD-SYNTH-GLN-RXN is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0000446 name: NAD+ nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [EC:3.2.2.5] subset: gosubset_prok synonym: "ADP-ribosyl cyclase activity" RELATED [EC:3.2.2.5] synonym: "diphosphopyridine nucleosidase activity" EXACT [EC:3.2.2.5] synonym: "DPN hydrolase activity" EXACT [EC:3.2.2.5] synonym: "DPNase activity" EXACT [EC:3.2.2.5] synonym: "NAD glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "NAD hydrolase activity" EXACT [EC:3.2.2.5] synonym: "NAD nucleosidase activity" EXACT [] synonym: "NAD+ glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "NADase activity" EXACT [EC:3.2.2.5] synonym: "nicotinamide adenine dinucleotide glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "nicotinamide adenine dinucleotide nucleosidase activity" EXACT [EC:3.2.2.5] xref: EC:3.2.2.5 xref: GO:0003953 xref: MetaCyc:NADNUCLEOSID-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0000447 name: NADH dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] subset: gosubset_prok synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3] synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3] synonym: "diaphorase activity" BROAD [EC:1.6.99.3] synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3] synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3] synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3] xref: EC:1.6.99.3 xref: GO:0003954 xref: MetaCyc:NADH-DEHYDROGENASE-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0000448 name: NAD(P)H dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)(+) + a hydroquinone." [EC:1.6.5.2] subset: gosubset_prok synonym: "azoreductase activity" BROAD [EC:1.6.5.2] synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" EXACT [EC:1.6.5.2] synonym: "diaphorase activity" BROAD [EC:1.6.5.2] synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2] synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H2 dehydrogenase (quinone)" EXACT [EC:1.6.5.2] synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2] synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "NQO1" RELATED [EC:1.6.5.2] synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "QR1" RELATED [EC:1.6.5.2] synonym: "quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2] xref: EC:1.6.5.2 xref: GO:0003955 xref: MetaCyc:NQOR-RXN is_a: CCO:F0003253 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: CCO:F0000449 name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31] synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT [] synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.31 xref: GO:0003956 xref: MetaCyc:2.4.2.31-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000450 name: NAD(P)+ transhydrogenase (B-specific) activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf?sessid] subset: gosubset_prok synonym: "H+-thase" BROAD [EC:1.6.1.1] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT [] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH:NAD+ oxidoreductase (B-specific)" EXACT [EC:1.6.1.1] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] synonym: "non-energy-linked transhydrogenase activity" EXACT [EC:1.6.1.1] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] xref: EC:1.6.1.1 xref: GO:0003957 xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN is_a: CCO:F0002094 ! NAD(P) transhydrogenase activity is_a: CCO:F0002559 ! hydrogen ion transmembrane transporter activity [Term] id: CCO:F0000451 name: NADPH-hemoprotein reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] subset: gosubset_prok synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4] synonym: "CPR activity" RELATED [EC:1.6.2.4] synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4] synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4] synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4] synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-ferrihemoprotein reductase activity" EXACT [] synonym: "NADPH:cytochrome c reductase activity" EXACT [] synonym: "NADPH:cytochrome P450 reductase activity" EXACT [] synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "POR" RELATED [EC:1.6.2.4] synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4] synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4] xref: EC:1.6.2.4 xref: GO:0003958 xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003251 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: CCO:F0000452 name: NADPH dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + quinone acceptor = NADP+ + hydroquinone." [EC:1.6.99.1] subset: gosubset_prok synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2 diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "old yellow enzyme" RELATED [EC:1.6.99.1] synonym: "OYE" RELATED [EC:1.6.99.1] synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH-diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.1] xref: EC:1.6.99.1 xref: GO:0003959 xref: GO:0008468 xref: GO:0016660 xref: MetaCyc:NADPH-DEHYDROGENASE-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0000453 name: NADPH:quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] subset: gosubset_prok synonym: "NADPH:quinone oxidoreductase activity" EXACT [EC:1.6.5.5] synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5] synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5] xref: EC:1.6.5.5 xref: GO:0003960 xref: MetaCyc:QOR-RXN is_a: CCO:F0003253 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: CCO:F0000454 name: O-acetylhomoserine aminocarboxypropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate." [EC:2.5.1.49] comment: Note that this function was formerly EC:4.2.99.10. subset: gosubset_prok synonym: "4.2.99.9" RELATED [] synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.49] synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT [] synonym: "O-acetylhomoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "OAH sulfhydrylase activity" EXACT [EC:2.5.1.49] xref: EC:2.5.1.49 xref: GO:0003961 xref: MetaCyc:O-ACETYLHOMOSERINE-(THIOL)-LYASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0000455 name: cystathionine gamma-synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48] comment: Formerly EC 4.2.99.9. subset: gosubset_prok synonym: "CTT gamma synthase activity" EXACT [] synonym: "cystathionine g-synthase activity" EXACT [] synonym: "cystathionine gamma synthase activity" EXACT [] synonym: "cystathionine synthase activity" EXACT [EC:2.5.1.48] synonym: "cystathionine synthetase activity" EXACT [EC:2.5.1.48] synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT [] synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" EXACT [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT [] synonym: "O-succinylhomoserine (thiol)-lyase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthetase activity" EXACT [EC:2.5.1.48] synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.48] xref: EC:2.5.1.48 xref: GO:0000505 xref: GO:0003962 xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0000456 name: RNA-3'-phosphate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] subset: gosubset_prok synonym: "RNA 3'-terminal phosphate cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4] xref: EC:6.5.1.4 xref: GO:0003963 xref: MetaCyc:RNA-3 is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003444 ! ligase activity, forming phosphoric ester bonds [Term] id: CCO:F0000457 name: RNA-directed DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] subset: gosubset_prok synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "DNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "reverse transcriptase activity" EXACT [EC:2.7.7.49] synonym: "revertase activity" RELATED [EC:2.7.7.49] synonym: "RNA revertase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW [] synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW [] synonym: "RNA-instructed DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RT" RELATED [EC:2.7.7.49] xref: EC:2.7.7.49 xref: GO:0003964 xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:10568 is_a: CCO:F0005510 ! DNA polymerase activity [Term] id: CCO:F0000458 name: RNA-directed RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA (n) = diphosphate + RNA (n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] subset: gosubset_prok synonym: "3D polymerase activity" EXACT [EC:2.7.7.48] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [EC:2.7.7.48] synonym: "PB1 proteins" RELATED [EC:2.7.7.48] synonym: "PB2 proteins" RELATED [EC:2.7.7.48] synonym: "phage f2 replicase" NARROW [EC:2.7.7.48] synonym: "polymerase L" RELATED [EC:2.7.7.48] synonym: "Q-beta replicase activity" EXACT [EC:2.7.7.48] synonym: "RDRP" RELATED [EC:2.7.7.48] synonym: "ribonucleic acid replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.48] synonym: "RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "transcriptase" BROAD [EC:2.7.7.48] xref: EC:2.7.7.48 xref: GO:0003968 xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:12642 is_a: CCO:F0005511 ! RNA polymerase activity [Term] id: CCO:F0000459 name: RNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m)." [EC:6.5.1.3] subset: gosubset_prok synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide ligase activity" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.3] synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3] xref: EC:6.5.1.3 xref: GO:0003972 xref: MetaCyc:RNA-LIGASE-(ATP)-RXN is_a: CCO:F0001915 ! RNA ligase activity [Term] id: CCO:F0000461 name: UDP-N-acetylglucosamine 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] subset: gosubset_prok synonym: "UDP acetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-GlcNAc 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphoacetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] xref: EC:5.1.3.7 xref: GO:0003974 xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0000462 name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15] subset: gosubset_prok synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15] synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] xref: EC:2.7.8.15 xref: GO:0003975 xref: MetaCyc:2.7.8.15-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0000463 name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17] synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminyl phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17] synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] xref: EC:2.7.8.17 xref: GO:0003976 xref: MetaCyc:2.7.8.17-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0000464 name: UDP-N-acetylglucosamine diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine." [EC:2.7.7.23] subset: gosubset_prok synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23] synonym: "GlmU uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UDP-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-GlcNAc pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] xref: EC:2.7.7.23 xref: GO:0003977 xref: MetaCyc:NAG1P-URIDYLTRANS-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000465 name: UDP-glucose 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] subset: gosubset_prok synonym: "4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2] synonym: "UDP-D-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-glucose epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPG-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPgalactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate glucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphospho-galactose-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose epimerase activity" EXACT [EC:5.1.3.2] xref: EC:5.1.3.2 xref: GO:0003978 xref: MetaCyc:UDPGLUCEPIM-RXN xref: Reactome:12673 is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0000466 name: UDP-glucose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + H+." [EC:1.1.1.22] subset: gosubset_prok xref: EC:1.1.1.22 xref: GO:0003979 xref: MetaCyc:UGD-RXN xref: Reactome:12674 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000467 name: UDP-glucose:glycoprotein glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [PMID:10764828] synonym: "UGGT activity" EXACT [] xref: EC:2.4.1.- xref: GO:0003980 is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0000468 name: UTP:glucose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose." [EC:2.7.7.9] subset: gosubset_prok synonym: "glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG phosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine-diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] xref: EC:2.7.7.9 xref: GO:0003983 xref: MetaCyc:GLUC1PURIDYLTRANS-RXN xref: Reactome:12708 is_a: CCO:F0008184 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: CCO:F0000469 name: acetolactate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [EC:2.2.1.6] comment: Note that this function was formerly EC:4.1.3.18. subset: gosubset_prok synonym: "acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "acetolactate pyruvate-lyase (carboxylating) activity" EXACT [EC:2.2.1.6] synonym: "acetolactic synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthetase activity" EXACT [EC:2.2.1.6] synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.6] xref: EC:2.2.1.6 xref: GO:0003984 xref: MetaCyc:ACETOLACTSYN-RXN is_a: CCO:F0003320 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: CCO:F0000470 name: acetyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9] subset: gosubset_prok synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9] synonym: "3-oxothiolase activity" EXACT [EC:2.3.1.9] synonym: "acetoacetyl-CoA thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:N-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "beta-acetoacetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "thiolase II" RELATED [EC:2.3.1.9] xref: EC:2.3.1.9 xref: GO:0003985 xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN xref: UM-BBD_enzymeID:e0144 is_a: CCO:F0003163 ! C-acetyltransferase activity [Term] id: CCO:F0000471 name: acetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O = CoA + acetate." [EC:3.1.2.1] subset: gosubset_prok synonym: "acetyl coenzyme A acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA thiol esterase activity" EXACT [EC:3.1.2.1] xref: EC:3.1.2.1 xref: GO:0003986 xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0000472 name: acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1] subset: gosubset_prok synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1] synonym: "acetate to acetyl-CoA" RELATED [] synonym: "acetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.1] synonym: "acetic thiokinase activity" EXACT [EC:6.2.1.1] synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1] synonym: "acetyl CoA ligase activity" EXACT [EC:6.2.1.1] synonym: "acetyl CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl coenzyme A synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-activating enzyme activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-coenzyme A synthase activity" EXACT [EC:6.2.1.1] synonym: "ACS" RELATED [EC:6.2.1.1] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1] synonym: "short chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "short-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.1] xref: EC:6.2.1.1 xref: GO:0003987 xref: MetaCyc:ACETATE--COA-LIGASE-RXN xref: Reactome:12714 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0000473 name: acetyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] subset: gosubset_prok synonym: "2-keto-acyl thiolase activity" EXACT [] synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16] synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl-CoA thiolase activity" EXACT [] synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "KAT" RELATED [EC:2.3.1.16] synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "thiolase I" RELATED [EC:2.3.1.16] xref: EC:2.3.1.16 xref: GO:0003988 xref: MetaCyc:KETOACYLCOATHIOL-RXN is_a: CCO:F0003131 ! C-acyltransferase activity [Term] id: CCO:F0000474 name: acetyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] subset: gosubset_prok synonym: "acetyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.2] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.2] xref: EC:6.4.1.2 xref: GO:0003989 xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN xref: Reactome:12716 is_a: CCO:F0003144 ! CoA carboxylase activity [Term] id: CCO:F0000475 name: acetylcholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] subset: gosubset_prok synonym: "AcCholE" RELATED [EC:3.1.1.7] synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7] synonym: "choline esterase I activity" EXACT [EC:3.1.1.7] synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7] xref: EC:3.1.1.7 xref: GO:0003990 xref: MetaCyc:ACETYLCHOLINESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0000476 name: acetylglutamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate." [EC:2.7.2.8] subset: gosubset_prok synonym: "acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate kinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamic 5-phosphotransferase activity" EXACT [EC:2.7.2.8] xref: EC:2.7.2.8 xref: GO:0003991 xref: MetaCyc:ACETYLGLUTKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0000477 name: acetylornithine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine aminotransferase activity" EXACT [] synonym: "acetylornithine delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "ACOAT activity" EXACT [EC:2.6.1.11] synonym: "N(2)-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine-delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT [] synonym: "N2-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11] xref: EC:2.6.1.11 xref: GO:0003992 xref: GO:0047318 xref: MetaCyc:ACETYLORNTRANSAM-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0000478 name: acid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] subset: gosubset_prok synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2] synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2] synonym: "uteroferrin" RELATED [EC:3.1.3.2] xref: EC:3.1.3.2 xref: GO:0003993 xref: MetaCyc:ACID-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0000479 name: aconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3] subset: gosubset_prok synonym: "aconitase activity" EXACT [] synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3] xref: EC:4.2.1.3 xref: GO:0003994 xref: MetaCyc:ACONITATEDEHYDR-RXN xref: Reactome:12740 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000480 name: acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] subset: gosubset_prok synonym: "acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "fatty acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "fatty-acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "general acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3] synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] xref: EC:1.3.99.3 xref: GO:0003995 xref: MetaCyc:ACYLCOADEHYDROG-RXN xref: Reactome:4266 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0000481 name: acyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl + ATP + CoASH = AMP + diphosphate + acyl-CoA." [GOC:mah] subset: gosubset_prok xref: EC:6.2.1.- xref: GO:0003996 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0000482 name: acyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2." [EC:1.3.3.6] subset: gosubset_prok synonym: "acyl coenzyme A oxidase activity" EXACT [EC:1.3.3.6] synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-CoA oxidase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-coenzyme A oxidase activity" EXACT [EC:1.3.3.6] xref: EC:1.3.3.6 xref: GO:0003997 xref: MetaCyc:ACYL-COA-OXIDASE-RXN is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0000483 name: acylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] subset: gosubset_prok synonym: "1,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetic phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetylphosphatase activity" EXACT [EC:3.6.1.7] synonym: "acylphosphate phosphohydrolase activity" EXACT [EC:3.6.1.7] synonym: "GP 1-3" RELATED [EC:3.6.1.7] synonym: "Ho 1-3" RELATED [EC:3.6.1.7] xref: EC:3.6.1.7 xref: GO:0003998 xref: MetaCyc:ACYLPHOSPHATASE-RXN is_a: CCO:F0003386 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: CCO:F0000484 name: adenine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7] subset: gosubset_prok synonym: "adenine phosphoribosylpyrophosphate transferase activity" EXACT [EC:2.4.2.7] synonym: "adenosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "adenylate pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "adenylic pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP diphosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "APRT activity" EXACT [EC:2.4.2.7] synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7] xref: EC:2.4.2.7 xref: GO:0003999 xref: MetaCyc:ADENPRIBOSYLTRAN-RXN xref: Reactome:12749 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000485 name: adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] subset: gosubset_prok synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4] synonym: "adenosine deaminase reaction" EXACT [] xref: EC:3.5.4.4 xref: GO:0004000 xref: MetaCyc:ADENODEAMIN-RXN xref: Reactome:6985 is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0000486 name: adenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] subset: gosubset_prok synonym: "adenosine 5-phosphotransferase activity" EXACT [] synonym: "adenosine kinase (phosphorylating)" EXACT [EC:2.7.1.20] synonym: "ATP:adenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.20] xref: EC:2.7.1.20 xref: GO:0004001 xref: MetaCyc:ADENOSINE-KINASE-RXN xref: Reactome:6989 is_a: CCO:F0004129 ! nucleoside kinase activity [Term] id: CCO:F0000487 name: ATP-dependent DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok xref: GO:0004003 is_a: CCO:F0000275 ! DNA helicase activity is_a: CCO:F0001682 ! ATP-dependent helicase activity is_a: CCO:F0001707 ! DNA-dependent ATPase activity [Term] id: CCO:F0000488 name: ATP-dependent RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok xref: GO:0004004 is_a: CCO:F0000309 ! RNA helicase activity is_a: CCO:F0001682 ! ATP-dependent helicase activity is_a: CCO:F0001767 ! RNA-dependent ATPase activity [Term] id: CCO:F0000489 name: copper-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)." [EC:3.6.3.4] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (Cu2+-exporting)" EXACT [EC:3.6.3.4] synonym: "copper exporting ATPase activity" EXACT [] synonym: "copper-translocating P-type ATPase activity" RELATED [EC:3.6.3.4] synonym: "Cu(2+)-exporting ATPase activity" EXACT [EC:3.6.3.4] synonym: "Cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] synonym: "cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] xref: EC:3.6.3.4 xref: GO:0004008 xref: MetaCyc:3.6.3.4-RXN is_a: CCO:F0005880 ! copper-transporting ATPase activity [Term] id: CCO:F0000490 name: phospholipid-translocating ATPase activity namespace: molecular_function def: "Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "aminophospholipid-transporting ATPase" NARROW [] synonym: "ATP phosphohydrolase (phospholipid-flipping)" EXACT [EC:3.6.3.1] synonym: "flippase activity" BROAD [EC:3.6.3.1] synonym: "magnesium-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg(2+)-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg2+-ATPase activity" EXACT [EC:3.6.3.1] synonym: "phospholipid translocating ATPase activity" EXACT [] synonym: "phospholipid-transporting ATPase activity" EXACT [EC:3.6.3.1] xref: EC:3.6.3.1 xref: GO:0004012 xref: GO:0008557 xref: MetaCyc:3.6.3.1-RXN is_a: CCO:F0002715 ! aminophospholipid transporter activity is_a: CCO:F0005860 ! ATPase activity, coupled to movement of substances [Term] id: CCO:F0000491 name: adenosylhomocysteinase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] subset: gosubset_prok synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1] synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1] synonym: "SAHase activity" EXACT [EC:3.3.1.1] xref: EC:3.3.1.1 xref: GO:0004013 xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN xref: Reactome:7047 is_a: CCO:F0003372 ! trialkylsulfonium hydrolase activity [Term] id: CCO:F0000492 name: adenosylmethionine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2." [EC:4.1.1.50] subset: gosubset_prok synonym: "adenosyl methionine decarboxylase activity" EXACT [] synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine decarboxylase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosylmethionine decarboxylase activity" EXACT [EC:4.1.1.50] xref: EC:4.1.1.50 xref: GO:0004014 xref: MetaCyc:SAMDECARB-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000493 name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate." [EC:2.6.1.62] subset: gosubset_prok synonym: "7,8-diamino-pelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminonanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT [] synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT [] synonym: "DAPA aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "DAPA transaminase activity" EXACT [EC:2.6.1.62] synonym: "diaminopelargonate synthase activity" EXACT [EC:2.6.1.62] synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] xref: EC:2.6.1.62 xref: GO:0004015 xref: MetaCyc:DAPASYN-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0000494 name: adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] subset: gosubset_prok synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1] synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1] synonym: "adenylyl cyclase activity" EXACT [] synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1] synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1] synonym: "cAMP generating peptide activity" RELATED [] xref: EC:4.6.1.1 xref: GO:0004016 xref: MetaCyc:ADENYLATECYC-RXN xref: Reactome:7056 is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003413 ! phosphorus-oxygen lyase activity [Term] id: CCO:F0000495 name: adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] subset: gosubset_prok synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylokinase activity" EXACT [EC:2.7.4.3] synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3] synonym: "myokinase activity" NARROW [EC:2.7.4.3] xref: EC:2.7.4.3 xref: GO:0004017 xref: MetaCyc:ADENYL-KIN-RXN is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor is_a: CCO:F0004124 ! nucleotide kinase activity [Term] id: CCO:F0000496 name: adenylosuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] subset: gosubset_prok synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "adenylosuccinase activity" EXACT [EC:4.3.2.2] synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "succino AMP-lyase activity" EXACT [EC:4.3.2.2] xref: EC:4.3.2.2 xref: GO:0004018 xref: MetaCyc:AMPSYN-RXN xref: Reactome:7065 is_a: CCO:F0003407 ! amidine-lyase activity [Term] id: CCO:F0000497 name: adenylosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP." [EC:6.3.4.4] subset: gosubset_prok synonym: "adenylosuccinate synthetase activity" EXACT [EC:6.3.4.4] synonym: "IMP--aspartate ligase activity" EXACT [EC:6.3.4.4] synonym: "IMP:L-aspartate ligase (GDP-forming)" EXACT [EC:6.3.4.4] synonym: "succino-AMP synthetase activity" EXACT [EC:6.3.4.4] synonym: "succinoadenylic kinosynthetase activity" EXACT [EC:6.3.4.4] xref: EC:6.3.4.4 xref: GO:0004019 xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN xref: Reactome:7069 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0000498 name: adenylylsulfate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25] subset: gosubset_prok synonym: "5'-phosphoadenosine sulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine 5'-phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT [] synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT [] synonym: "adenylyl-sulfate kinase activity" EXACT [] synonym: "adenylyl-sulphate kinase activity" EXACT [] synonym: "adenylylsulfate kinase (phosphorylating)" EXACT [EC:2.7.1.25] synonym: "APS kinase activity" EXACT [EC:2.7.1.25] synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" EXACT [EC:2.7.1.25] xref: EC:2.7.1.25 xref: GO:0004020 xref: MetaCyc:ADENYLYLSULFKIN-RXN xref: Reactome:7077 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000499 name: alanine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate." [EC:2.6.1.2] subset: gosubset_prok synonym: "alanine aminotransferase activity" EXACT [] synonym: "alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "alanine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "ALT" RELATED [EC:2.6.1.2] synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2] synonym: "glutamic acid-pyruvic acid transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--alanine transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--pyruvic transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic-pyruvic aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "GPT" RELATED [EC:2.6.1.2] synonym: "L-alanine aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "L-alanine transaminase activity" EXACT [EC:2.6.1.2] synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "L-alanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate transaminase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate-alanine aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2] xref: EC:2.6.1.2 xref: GO:0004021 xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN xref: Reactome:7079 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0000500 name: alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] subset: gosubset_prok synonym: "ADH" RELATED [EC:1.1.1.1] synonym: "alcohol dehydrogenase (NAD) activity" NARROW [] synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1] synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1] synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] xref: EC:1.1.1.1 xref: GO:0004022 xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN xref: UM-BBD_enzymeID:e0023 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000501 name: alcohol dehydrogenase activity, metal ion-independent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah] xref: GO:0004023 is_a: CCO:F0000500 ! alcohol dehydrogenase activity [Term] id: CCO:F0000502 name: alcohol dehydrogenase activity, zinc-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ requiring the presence of zinc." [EC:1.1.1.1, GOC:mah] subset: gosubset_prok xref: GO:0004024 xref: Reactome:7085 is_a: CCO:F0000500 ! alcohol dehydrogenase activity [Term] id: CCO:F0000503 name: alcohol dehydrogenase activity, iron-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah] subset: gosubset_prok xref: GO:0004025 is_a: CCO:F0000500 ! alcohol dehydrogenase activity [Term] id: CCO:F0000504 name: alcohol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84] synonym: "AATASE activity" EXACT [EC:2.3.1.84] synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84] synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84] xref: EC:2.3.1.84 xref: GO:0004026 xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity is_a: CCO:F0008349 ! alcohol O-acyltransferase activity [Term] id: CCO:F0000505 name: alcohol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] subset: gosubset_prok synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "alcohol sulphotransferase activity" EXACT [] synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] synonym: "HST" RELATED [EC:2.8.2.2] synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2] xref: EC:2.8.2.2 xref: GO:0004027 xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN xref: Reactome:7092 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0000506 name: 3-chloroallyl aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432] subset: gosubset_prok xref: EC:1.2.1.- xref: GO:0004028 xref: Reactome:7095 xref: UM-BBD_enzymeID:e0432 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000507 name: aldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3] subset: gosubset_prok synonym: "aldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.3] synonym: "aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.3] synonym: "CoA-independent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "m-methylbenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-linked aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "propionaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] xref: EC:1.2.1.3 xref: GO:0004029 xref: MetaCyc:ALDHDEHYDROG-RXN xref: Reactome:7097 xref: UM-BBD_enzymeID:e0024 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000508 name: aldehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5] subset: gosubset_prok synonym: "aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.5] synonym: "ALDH" RELATED [EC:1.2.1.5] xref: EC:1.2.1.5 xref: GO:0004030 xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-(NAD(P)+)-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000509 name: aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + H2O2." [EC:1.2.3.1] subset: gosubset_prok synonym: "aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.1] synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1] xref: EC:1.2.3.1 xref: GO:0004031 xref: MetaCyc:ALDEHYDE-OXIDASE-RXN is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0000510 name: aldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] subset: gosubset_prok synonym: "aldose reductase activity" EXACT [EC:1.1.1.21] synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21] xref: EC:1.1.1.21 xref: GO:0004032 xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN is_a: CCO:F0000511 ! aldo-keto reductase activity [Term] id: CCO:F0000511 name: aldo-keto reductase activity namespace: molecular_function def: "Catalysis of the NADPH-dependent reduction of carbonyl compounds." [GOC:jl, PMID:2498333] subset: gosubset_prok xref: EC:1.1.1.- xref: GO:0004033 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000512 name: aldose 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3] subset: gosubset_prok synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3] synonym: "mutarotase activity" RELATED [EC:5.1.3.3] xref: EC:5.1.3.3 xref: GO:0004034 xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0000513 name: alkaline phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] subset: gosubset_prok synonym: "alkaline phenyl phosphatase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphohydrolase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphomonoesterase activity" EXACT [EC:3.1.3.1] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1] synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1] xref: EC:3.1.3.1 xref: GO:0004035 xref: MetaCyc:ALKAPHOSPHA-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0000514 name: allantoicase activity namespace: molecular_function def: "Catalysis of the reaction: allantoate + H2O = (-)-ureidoglycolate + urea." [EC:3.5.3.4] subset: gosubset_prok synonym: "allantoate amidinohydrolase activity" EXACT [EC:3.5.3.4] synonym: "allantoine amidinohydrolase activity" EXACT [] xref: EC:3.5.3.4 xref: GO:0004037 xref: MetaCyc:ALLANTOICASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0000515 name: allantoinase activity namespace: molecular_function def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5] subset: gosubset_prok synonym: "(S)-allantoin amidohydrolase activity" EXACT [EC:3.5.2.5] xref: EC:3.5.2.5 xref: GO:0004038 xref: MetaCyc:ALLANTOINASE-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0000516 name: allophanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: urea-1-carboxylate + H2O = 2 CO2 + 2 NH3." [EC:3.5.1.54] subset: gosubset_prok synonym: "allophanate lyase activity" EXACT [EC:3.5.1.54] synonym: "urea-1-carboxylate amidohydrolase activity" EXACT [EC:3.5.1.54] xref: EC:3.5.1.54 xref: GO:0004039 xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000517 name: amidase activity namespace: molecular_function def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4] subset: gosubset_prok synonym: "acetamidase activity" EXACT [] synonym: "acylamidase activity" EXACT [EC:3.5.1.4] synonym: "acylamide amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "acylase activity" EXACT [EC:3.5.1.4] synonym: "amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4] synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4] xref: EC:3.5.1.4 xref: GO:0004040 xref: MetaCyc:AMIDASE-RXN xref: UM-BBD_enzymeID:e0068 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000518 name: amino-acid N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate." [EC:2.3.1.1] subset: gosubset_prok synonym: "acetyl-CoA:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.1] synonym: "acetylglutamate acetylglutamate synthetase activity" EXACT [EC:2.3.1.1] synonym: "AGAS" RELATED [EC:2.3.1.1] synonym: "amino acid acetyltransferase activity" EXACT [EC:2.3.1.1] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1] xref: EC:2.3.1.1 xref: GO:0004042 xref: MetaCyc:N-ACETYLTRANSFER-RXN xref: Reactome:7143 is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0000519 name: L-aminoadipate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] subset: gosubset_prok synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "AAR" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31] xref: EC:1.2.1.31 xref: GO:0004043 xref: MetaCyc:1.2.1.31-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000520 name: amidophosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O." [EC:2.4.2.14] subset: gosubset_prok synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" EXACT [EC:2.4.2.14] synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribose pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyl pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" EXACT [EC:2.4.2.14] xref: EC:2.4.2.14 xref: GO:0004044 xref: MetaCyc:PRPPAMIDOTRANS-RXN xref: Reactome:7147 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000521 name: aminoacyl-tRNA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29] subset: gosubset_prok synonym: "aminoacyl-transfer ribonucleate hydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA aminoacylhydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1.1.29] synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29] xref: EC:3.1.1.29 xref: GO:0004045 xref: GO:0019850 xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0000522 name: aminoacylase activity namespace: molecular_function def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] subset: gosubset_prok synonym: "acylase I activity" NARROW [EC:3.5.1.14] synonym: "alpha-N-acylaminoacid hydrolase activity" EXACT [EC:3.5.1.14] synonym: "amido acid deacylase activity" EXACT [EC:3.5.1.14] synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14] synonym: "benzamidase activity" RELATED [EC:3.5.1.14] synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14] synonym: "hippurase activity" EXACT [EC:3.5.1.14] synonym: "histozyme activity" RELATED [EC:3.5.1.14] synonym: "L-amino-acid acylase activity" EXACT [EC:3.5.1.14] synonym: "L-aminoacylase activity" EXACT [EC:3.5.1.14] synonym: "long acyl amidoacylase activity" EXACT [EC:3.5.1.14] synonym: "N-acyl-L-amino-acid amidohydrolase activity" EXACT [EC:3.5.1.14] synonym: "short acyl amidoacylase activity" EXACT [EC:3.5.1.14] xref: EC:3.5.1.14 xref: GO:0004046 xref: MetaCyc:AMINOACYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000523 name: aminomethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] subset: gosubset_prok synonym: "glycine synthase activity" RELATED [EC:2.1.2.10] synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10] synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "T-protein" RELATED [EC:2.1.2.10] synonym: "tetrahydrofolate aminomethyltransferase activity" EXACT [EC:2.1.2.10] xref: EC:2.1.2.10 xref: GO:0004047 xref: MetaCyc:GCVT-RXN is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0000524 name: anthranilate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-a-D-ribose 1-diphosphate." [EC:2.4.2.18] subset: gosubset_prok synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate diphosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate transferase activity" EXACT [EC:2.4.2.18] synonym: "PRT" RELATED [EC:2.4.2.18] xref: EC:2.4.2.18 xref: GO:0004048 xref: MetaCyc:PRTRANS-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000525 name: anthranilate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27] subset: gosubset_prok synonym: "anthranilate synthetase activity" EXACT [EC:4.1.3.27] synonym: "chorismate pyruvate-lyase (amino-accepting) activity" EXACT [EC:4.1.3.27] xref: EC:4.1.3.27 xref: GO:0004049 xref: MetaCyc:ANTHRANSYN-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0000526 name: arachidonate 5-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34] subset: gosubset_prok synonym: "5-delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5Delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonate:oxygen 5-oxidoreductase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic acid 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34] synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34] synonym: "leukotriene-A4 synthase activity" EXACT [EC:1.13.11.34] synonym: "LTA synthase activity" NARROW [EC:1.13.11.34] xref: EC:1.13.11.34 xref: GO:0004051 xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0000527 name: arachidonate 12-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31] synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31] synonym: "12Delta-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "12S-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "arachidonate:oxygen 12-oxidoreductase activity" EXACT [EC:1.13.11.31] synonym: "C-12 lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "delta12-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31] synonym: "LTA4 synthase activity" EXACT [EC:1.13.11.31] xref: EC:1.13.11.31 xref: GO:0004052 xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0000528 name: arginase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1] subset: gosubset_prok synonym: "arginine amidinase activity" EXACT [EC:3.5.3.1] synonym: "arginine transamidinase activity" EXACT [EC:3.5.3.1] synonym: "canavanase activity" EXACT [EC:3.5.3.1] synonym: "L-arginase activity" EXACT [EC:3.5.3.1] synonym: "L-arginine amidinohydrolase activity" EXACT [EC:3.5.3.1] xref: EC:3.5.3.1 xref: GO:0004053 xref: MetaCyc:ARGINASE-RXN xref: Reactome:7167 is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0000529 name: arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-arginine = ADP + N-phospho-L-arginine." [EC:2.7.3.3] synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" EXACT [EC:2.7.3.3] synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3] synonym: "arginine phosphokinase activity" EXACT [EC:2.7.3.3] synonym: "ATP:L-arginine N-phosphotransferase activity" EXACT [EC:2.7.3.3] xref: EC:2.7.3.3 xref: GO:0004054 xref: MetaCyc:ARGININE-KINASE-RXN is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor is_a: CCO:F0004125 ! amino acid kinase activity [Term] id: CCO:F0000530 name: argininosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate." [EC:6.3.4.5] subset: gosubset_prok synonym: "arginine succinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinic acid synthetase activity" EXACT [EC:6.3.4.5] synonym: "arginosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "citrulline--aspartate ligase activity" EXACT [EC:6.3.4.5] synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [EC:6.3.4.5] xref: EC:6.3.4.5 xref: GO:0004055 xref: MetaCyc:ARGSUCCINSYN-RXN xref: Reactome:7171 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0000531 name: argininosuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1] subset: gosubset_prok synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "arginine-succinate lyase activity" EXACT [EC:4.3.2.1] synonym: "argininosuccinic acid lyase activity" EXACT [EC:4.3.2.1] synonym: "arginosuccinase activity" EXACT [EC:4.3.2.1] synonym: "N-(L-argininosuccinate) arginine-lyase activity" EXACT [EC:4.3.2.1] synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" EXACT [EC:4.3.2.1] xref: EC:4.3.2.1 xref: GO:0004056 xref: MetaCyc:ARGSUCCINLYA-RXN xref: Reactome:7173 is_a: CCO:F0003407 ! amidine-lyase activity [Term] id: CCO:F0000532 name: arginyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8] subset: gosubset_prok synonym: "arginine transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA-protein transferase activity" EXACT [] synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8] xref: EC:2.3.2.8 xref: GO:0004057 xref: GO:0042172 xref: MetaCyc:ARGINYLTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0000533 name: aromatic-L-amino-acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan = tryptamine + CO2." [EC:4.1.1.28] synonym: "5-hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic amino acid decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase activity" EXACT [EC:4.1.1.28] synonym: "DOPA decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "L-DOPA decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "tryptophan decarboxylase activity" EXACT [EC:4.1.1.28] xref: EC:4.1.1.28 xref: GO:0004058 xref: GO:0016400 xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000534 name: aralkylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87] synonym: "AANAT activity" EXACT [EC:2.3.1.87] synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "arylalkylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87] synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87] synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87] synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87] xref: EC:2.3.1.87 xref: GO:0004059 xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0000535 name: arylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5] subset: gosubset_prok synonym: "2-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "4-aminobiphenyl N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl CoA-arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetylase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "beta-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "indoleamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "p-aminosalicylate N-acetyltransferase activity" EXACT [EC:2.3.1.5] xref: EC:2.3.1.5 xref: GO:0004060 xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:7187 xref: UM-BBD_enzymeID:e0341 is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0000536 name: arylformamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9] subset: gosubset_prok synonym: "aryl-formylamine amidohydrolase activity" EXACT [EC:3.5.1.9] synonym: "formamidase I" RELATED [EC:3.5.1.9] synonym: "formamidase II" RELATED [EC:3.5.1.9] synonym: "formylase activity" EXACT [EC:3.5.1.9] synonym: "formylkynureninase activity" EXACT [EC:3.5.1.9] synonym: "formylkynurenine formamidase activity" EXACT [EC:3.5.1.9] synonym: "kynurenine formamidase activity" EXACT [EC:3.5.1.9] xref: EC:3.5.1.9 xref: GO:0004061 xref: MetaCyc:ARYLFORMAMIDASE-RXN xref: Reactome:7190 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000537 name: aryl sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] subset: gosubset_prok synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "aryl sulphotransferase activity" EXACT [] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "PST" RELATED [EC:2.8.2.1] synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] xref: EC:2.8.2.1 xref: GO:0004062 xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN xref: Reactome:7193 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0000538 name: aryldialkylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1] subset: gosubset_prok synonym: "A-esterase activity" BROAD [EC:3.1.8.1] synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1] synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1] synonym: "esterase B1" RELATED [EC:3.1.8.1] synonym: "esterase E4" RELATED [EC:3.1.8.1] synonym: "OPH" RELATED [EC:3.1.8.1] synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1] synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1] synonym: "paraoxonase activity" BROAD [EC:3.1.8.1] synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1] synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1] xref: EC:3.1.8.1 xref: GO:0004063 xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN xref: UM-BBD_enzymeID:e0054 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0000539 name: arylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] subset: gosubset_prok synonym: "A-esterase activity" BROAD [EC:3.1.1.2] synonym: "aromatic esterase" NARROW [EC:3.1.1.2] synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2] synonym: "paraoxonase activity" BROAD [EC:3.1.1.2] xref: EC:3.1.1.2 xref: GO:0004064 xref: MetaCyc:ARYLESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0000540 name: arylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + SO4(2-) (sulfate)." [EC:3.1.6.1] subset: gosubset_prok synonym: "4-methylumbelliferyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulphate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulphatase activity" EXACT [] synonym: "estrogen sulfatase activity" EXACT [EC:3.1.6.1] synonym: "nitrocatechol sulfatase activity" EXACT [EC:3.1.6.1] synonym: "p-nitrophenyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenolsulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1] synonym: "sulfatase activity" RELATED [EC:3.1.6.1] xref: EC:3.1.6.1 xref: GO:0004065 xref: MetaCyc:ARYLSULFAT-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0000541 name: asparagine synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4] subset: gosubset_prok synonym: "AS" RELATED [EC:6.3.5.4] synonym: "AS-B activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase B activity" EXACT [EC:6.3.5.4] synonym: "glutamine-dependent asparagine synthetase activity" EXACT [EC:6.3.5.4] synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.4] xref: EC:6.3.5.4 xref: GO:0004066 xref: MetaCyc:ASNSYNB-RXN xref: Reactome:7213 is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0000542 name: asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] subset: gosubset_prok synonym: "alpha-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "asparaginase II" RELATED [EC:3.5.1.1] synonym: "colaspase activity" EXACT [EC:3.5.1.1] synonym: "crasnitin" RELATED [EC:3.5.1.1] synonym: "elspar" RELATED [EC:3.5.1.1] synonym: "L-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.1] synonym: "leunase activity" EXACT [EC:3.5.1.1] xref: EC:3.5.1.1 xref: GO:0004067 xref: MetaCyc:ASPARAGHYD-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000543 name: aspartate 1-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] subset: gosubset_prok synonym: "aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" EXACT [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase activity" EXACT [EC:4.1.1.11] synonym: "L-aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] xref: EC:4.1.1.11 xref: GO:0004068 xref: MetaCyc:ASPDECARBOX-RXN xref: MetaCyc:PWY-5155 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000544 name: aspartate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] subset: gosubset_prok synonym: "2-oxoglutarate-glutamate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "AAT" RELATED [EC:2.6.1.1] synonym: "aspartate alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate aminotransferase activity" EXACT [] synonym: "aspartate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "aspartic acid aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "aspartic aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "aspartyl aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "AspT" RELATED [EC:2.6.1.1] synonym: "glutamate oxaloacetate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic oxalic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--aspartic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--oxaloacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-aspartic aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-oxalacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1] synonym: "L-aspartate transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate-transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartic aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "oxaloacetate transferase activity" EXACT [EC:2.6.1.1] synonym: "oxaloacetate-aspartate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "transaminase A activity" EXACT [EC:2.6.1.1] xref: EC:2.6.1.1 xref: GO:0004069 xref: MetaCyc:ASPAMINOTRANS-RXN xref: Reactome:7220 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0000545 name: aspartate carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate." [EC:2.1.3.2] subset: gosubset_prok synonym: "aspartate carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic acid transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartic transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "ATCase activity" EXACT [EC:2.1.3.2] synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" EXACT [EC:2.1.3.2] synonym: "carbamoylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "carbamylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] xref: EC:2.1.3.2 xref: GO:0004070 xref: MetaCyc:ASPCARBTRANS-RXN xref: Reactome:7225 is_a: CCO:F0003319 ! carboxyl- or carbamoyltransferase activity [Term] id: CCO:F0000546 name: aspartate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1] subset: gosubset_prok synonym: "asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-aspartate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.1] xref: EC:6.3.1.1 xref: GO:0004071 xref: MetaCyc:ASNSYNA-RXN is_a: CCO:F0003071 ! ammonia ligase activity [Term] id: CCO:F0000547 name: aspartate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate." [EC:2.7.2.4] subset: gosubset_prok synonym: "aspartic kinase activity" EXACT [EC:2.7.2.4] synonym: "aspartokinase activity" EXACT [EC:2.7.2.4] synonym: "ATP:L-aspartate 4-phosphotransferase activity" EXACT [EC:2.7.2.4] synonym: "beta-aspartokinase activity" EXACT [EC:2.7.2.4] xref: EC:2.7.2.4 xref: GO:0004072 xref: MetaCyc:ASPARTATEKIN-RXN is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor is_a: CCO:F0004125 ! amino acid kinase activity [Term] id: CCO:F0000548 name: aspartate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate-4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH + H+." [EC:1.2.1.11] subset: gosubset_prok synonym: "ASA dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" EXACT [EC:1.2.1.11] xref: EC:1.2.1.11 xref: GO:0004073 xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000549 name: biliverdin reductase activity namespace: molecular_function def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24] synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24] xref: EC:1.3.1.24 xref: GO:0004074 xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000550 name: biotin carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] subset: gosubset_prok synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXACT [EC:6.3.4.14] synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14] xref: EC:6.3.4.14 xref: GO:0004075 xref: MetaCyc:BIOTIN-CARBOXYL-RXN is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0000551 name: biotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: dethiobiotin + sulfur = biotin." [EC:2.8.1.6] subset: gosubset_prok synonym: "biotin synthetase activity" EXACT [EC:2.8.1.6] synonym: "dethiobiotin:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.6] xref: EC:2.8.1.6 xref: GO:0004076 xref: MetaCyc:2.8.1.6-RXN is_a: CCO:F0003355 ! sulfurtransferase activity [Term] id: CCO:F0000552 name: biotin-[acetyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15] subset: gosubset_prok synonym: "acetyl CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15] synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15] synonym: "biotin-acetyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.15] synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "HCS" RELATED [EC:6.3.4.15] xref: EC:6.3.4.15 xref: GO:0004077 xref: MetaCyc:BIOTINLIG-RXN is_a: CCO:F0003637 ! biotin-protein ligase activity [Term] id: CCO:F0000553 name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11] synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11] synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11] synonym: "holocarboxylase-synthetase activity" EXACT [EC:6.3.4.11] xref: EC:6.3.4.11 xref: GO:0004078 xref: MetaCyc:6.3.4.11-RXN is_a: CCO:F0003637 ! biotin-protein ligase activity [Term] id: CCO:F0000554 name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [] synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-transcarboxylase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9] xref: EC:6.3.4.9 xref: GO:0004079 xref: MetaCyc:6.3.4.9-RXN is_a: CCO:F0003637 ! biotin-protein ligase activity [Term] id: CCO:F0000555 name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10] synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.10] synonym: "holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] xref: EC:6.3.4.10 xref: GO:0004080 xref: MetaCyc:6.3.4.10-RXN is_a: CCO:F0003637 ! biotin-protein ligase activity [Term] id: CCO:F0000556 name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726] subset: gosubset_prok synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17] synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW [] synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] xref: EC:3.6.1.17 xref: GO:0004081 xref: MetaCyc:3.6.1.17-RXN is_a: CCO:F0002141 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: CCO:F0000557 name: bisphosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" EXACT [EC:5.4.2.4] synonym: "biphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4] synonym: "BPGM activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceric mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "DPGM" RELATED [EC:5.4.2.4] synonym: "glycerate phosphomutase activity" EXACT [EC:5.4.2.4] xref: EC:5.4.2.4 xref: GO:0004082 xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0000558 name: bisphosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate." [EC:3.1.3.13, GOC:mah, PMID:18413611] synonym: "2,3-bisphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13] synonym: "2,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13] synonym: "2,3-diphosphoglyceric acid phosphatase activity" EXACT [EC:3.1.3.13] synonym: "diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13] synonym: "glycerate-2,3-diphosphate phosphatase activity" EXACT [EC:3.1.3.13] xref: GO:0034416 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0000559 name: branched-chain-amino-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine." [EC:2.6.1.42, GOC:mah] subset: gosubset_prok synonym: "branched-chain amino acid aminotransferase activity" EXACT [] synonym: "branched-chain amino acid-glutamate transaminase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "glutamate-branched-chain amino acid transaminase activity" EXACT [EC:2.6.1.42] synonym: "L-branched chain amino acid aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "transaminase B activity" RELATED [EC:2.6.1.42] xref: EC:2.6.1.42 xref: GO:0004084 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN xref: Reactome:70697 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0000560 name: butyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + ETF = 2-butenoyl-CoA + reduced ETF." [EC:1.3.99.2] subset: gosubset_prok synonym: "3-hydroxyacyl CoA reductase activity" EXACT [EC:1.3.99.2] synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2] synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2] synonym: "butyryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "butyryl dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "enoyl-coenzyme A reductase activity" EXACT [EC:1.3.99.2] synonym: "ethylene reductase activity" EXACT [EC:1.3.99.2] synonym: "short-chain acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "short-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.2] synonym: "unsaturated acyl coenzyme A reductase activity" EXACT [EC:1.3.99.2] synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.99.2] xref: EC:1.3.99.2 xref: GO:0004085 xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0034 is_a: CCO:F0000480 ! acyl-CoA dehydrogenase activity [Term] id: CCO:F0000561 name: carbamoyl-phosphate synthase activity namespace: molecular_function def: "Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah] subset: gosubset_prok synonym: "carbamoyl phosphate synthase activity" EXACT [] xref: EC:6.3.-.- xref: GO:0004086 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0000562 name: carbamoyl-phosphate synthase (ammonia) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate." [EC:6.3.4.16] subset: gosubset_prok synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT [] synonym: "carbamoyl-phosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamoyl-phosphate synthetase I activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase (ammonia)" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16] synonym: "carbmoylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide--ammonia ligase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" EXACT [EC:6.3.4.16] synonym: "CPS I activity" NARROW [EC:6.3.4.16] xref: EC:6.3.4.16 xref: GO:0004087 xref: MetaCyc:6.3.4.16-RXN xref: Reactome:7296 is_a: CCO:F0000561 ! carbamoyl-phosphate synthase activity [Term] id: CCO:F0000563 name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5] subset: gosubset_prok synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "carbamoyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoylphosphate synthetase II activity" EXACT [EC:6.3.5.5] synonym: "carbamyl phosphate synthetase (glutamine) activity" EXACT [EC:6.3.5.5] synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] synonym: "CPS activity" EXACT [EC:6.3.5.5] synonym: "GD-CPSase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] xref: EC:6.3.5.5 xref: GO:0004088 xref: MetaCyc:CARBPSYN-RXN xref: Reactome:7299 is_a: CCO:F0000561 ! carbamoyl-phosphate synthase activity is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0000564 name: carbonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] subset: gosubset_prok synonym: "anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase activity" EXACT [EC:4.2.1.1] synonym: "carbonic acid anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1] synonym: "carbonic anhydrase activity" EXACT [] synonym: "carbonic dehydratase activity" EXACT [EC:4.2.1.1] synonym: "carboxyanhydrase activity" EXACT [EC:4.2.1.1] xref: EC:4.2.1.1 xref: GO:0004089 xref: MetaCyc:CARBODEHYDRAT-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000565 name: carbonyl reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184] subset: gosubset_prok synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184] synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184] synonym: "ALR3" RELATED [EC:1.1.1.184] synonym: "carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH2-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "nonspecific NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184] synonym: "secondary-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.184] synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184] xref: EC:1.1.1.184 xref: GO:0004090 xref: MetaCyc:CARBONYL-REDUCTASE-(NADPH)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000566 name: carboxylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1] subset: gosubset_prok synonym: "Ali-esterase activity" RELATED [EC:3.1.1] synonym: "ali-esterase activity" EXACT [EC:3.1.1] synonym: "alpha-carboxylesterase activity" EXACT [EC:3.1.1] synonym: "B-esterase activity" RELATED [EC:3.1.1] synonym: "carboxyesterase activity" EXACT [EC:3.1.1] synonym: "carboxyl ester hydrolase activity" EXACT [EC:3.1.1] synonym: "carboxylate esterase activity" EXACT [EC:3.1.1] synonym: "carboxylic acid esterase activity" EXACT [] synonym: "carboxylic ester hydrolase activity" EXACT [] synonym: "carboxylic esterase activity" EXACT [EC:3.1.1] synonym: "carboxylic-ester hydrolase activity" EXACT [EC:3.1.1] synonym: "cocaine esterase activity" NARROW [EC:3.1.1] synonym: "esterase A" RELATED [EC:3.1.1] synonym: "esterase B" RELATED [EC:3.1.1] synonym: "nonspecific carboxylesterase activity" EXACT [EC:3.1.1] synonym: "procaine esterase activity" NARROW [EC:3.1.1] synonym: "serine esterase activity" EXACT [] synonym: "triacetin esterase" NARROW [EC:3.1.1] synonym: "vitamin A esterase" NARROW [EC:3.1.1] xref: EC:3.1.1 xref: EC:3.1.1.1 xref: GO:0004091 xref: GO:0004302 xref: GO:0004759 xref: GO:0016789 xref: MetaCyc:CARBOXYLESTERASE-RXN is_a: CCO:F0003360 ! hydrolase activity, acting on ester bonds [Term] id: CCO:F0000567 name: carnitine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + carnitine = CoA + O-acetylcarnitine." [EC:2.3.1.7] subset: gosubset_prok synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetylcarnitine transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyl coenzyme A transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetylase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine O-acetyltransferase I activity" NARROW [] synonym: "carnitine O-acetyltransferase II activity" NARROW [] synonym: "carnitine-acetyl-CoA transferase activity" EXACT [EC:2.3.1.7] synonym: "CATC" RELATED [EC:2.3.1.7] xref: EC:2.3.1.7 xref: GO:0004092 xref: GO:0004093 xref: GO:0004094 xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN is_a: CCO:F0003129 ! carnitine O-acyltransferase activity is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0000568 name: carnitine O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21] synonym: "acylcarnitine transferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21] synonym: "CPT" RELATED [EC:2.3.1.21] synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21] synonym: "CPT-A" RELATED [EC:2.3.1.21] synonym: "CPT-B" RELATED [EC:2.3.1.21] synonym: "CPTi" RELATED [EC:2.3.1.21] synonym: "CPTo" RELATED [EC:2.3.1.21] synonym: "L-carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoylcarnitine transferase activity" EXACT [EC:2.3.1.21] xref: EC:2.3.1.21 xref: GO:0004095 xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN is_a: CCO:F0003129 ! carnitine O-acyltransferase activity is_a: CCO:F0003139 ! O-palmitoyltransferase activity [Term] id: CCO:F0000569 name: catalase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O." [EC:1.11.1.6] subset: gosubset_prok synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "caperase activity" EXACT [EC:1.11.1.6] synonym: "CAT" RELATED [EC:1.11.1.6] synonym: "catalase reaction" EXACT [] synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6] synonym: "equilase activity" EXACT [EC:1.11.1.6] synonym: "haem catalase activity" NARROW [] synonym: "heme catalase activity" NARROW [] synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6] synonym: "manganese catalase activity" NARROW [] synonym: "optidase activity" EXACT [EC:1.11.1.6] xref: EC:1.11.1.6 xref: GO:0004096 xref: GO:0016952 xref: GO:0016953 xref: MetaCyc:CATAL-RXN xref: Reactome:76029 is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0000570 name: catechol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1] subset: gosubset_prok synonym: "1,2-benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.1] synonym: "catecholase" BROAD [EC:1.10.3.1] synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "dopa oxidase" BROAD [EC:1.10.3.1] synonym: "o-diphenol oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1] synonym: "phenolase activity" BROAD [EC:1.10.3.1] synonym: "polyphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "pyrocatechol oxidase" BROAD [EC:1.10.3.1] synonym: "tyrosinase activity" BROAD [EC:1.10.3.1] xref: EC:1.10.3.1 xref: GO:0004097 xref: MetaCyc:CATECHOL-OXIDASE-RXN is_a: CCO:F0003273 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: CCO:F0000571 name: cerebroside-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + SO4(2-) (sulfate)." [EC:3.1.6.8] subset: gosubset_prok synonym: "arylsulfatase A activity" EXACT [EC:3.1.6.8] synonym: "cerebroside sulfate sulfatase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-sulphatase activity" EXACT [] xref: EC:3.1.6.8 xref: GO:0004098 xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0000572 name: chitin deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41] subset: gosubset_prok synonym: "chitin amidohydrolase activity" EXACT [EC:3.5.1.41] xref: EC:3.5.1.41 xref: GO:0004099 xref: MetaCyc:CHITIN-DEACETYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0000573 name: chitin synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n+1)." [EC:2.4.1.16] subset: gosubset_prok synonym: "chitin synthetase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16] xref: EC:2.4.1.16 xref: GO:0004100 xref: MetaCyc:CHITIN-SYNTHASE-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0000574 name: choline O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + choline = CoA + O-acetylcholine." [EC:2.3.1.6] subset: gosubset_prok synonym: "acetyl-CoA:choline O-acetyltransferase activity" EXACT [EC:2.3.1.6] synonym: "CHOACTase activity" EXACT [EC:2.3.1.6] synonym: "choline acetylase activity" EXACT [EC:2.3.1.6] synonym: "choline acetyltransferase activity" EXACT [EC:2.3.1.6] xref: EC:2.3.1.6 xref: GO:0004102 xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0000575 name: choline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + choline = ADP + O-phosphocholine." [EC:2.7.1.32] subset: gosubset_prok synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32] synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32] synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32] synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32] xref: EC:2.7.1.32 xref: GO:0004103 xref: MetaCyc:CHOLINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000576 name: cholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] subset: gosubset_prok synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8] synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8] synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "BtChoEase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8] synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8] synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8] xref: EC:3.1.1.8 xref: GO:0004104 xref: MetaCyc:CHOLINESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0000577 name: choline-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15] subset: gosubset_prok synonym: "CDP-choline pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "CDP-choline synthetase activity" EXACT [EC:2.7.7.15] synonym: "choline phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP-phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "cytidine diphosphocholine pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine transferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine:CTP cytidylyltransferase activity" EXACT [EC:2.7.7.15] xref: EC:2.7.7.15 xref: GO:0004105 xref: MetaCyc:2.7.7.15-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000578 name: chorismate mutase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5] subset: gosubset_prok synonym: "chorismate pyruvatemutase activity" EXACT [EC:5.4.99.5] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5] xref: EC:5.4.99.5 xref: GO:0004106 xref: MetaCyc:CHORISMATEMUT-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0000579 name: chorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5] subset: gosubset_prok synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" EXACT [EC:4.2.3.5] xref: EC:4.2.3.5 xref: GO:0004107 xref: MetaCyc:CHORISMATE-SYNTHASE-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0000580 name: citrate (Si)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA." [EC:2.3.3.1] comment: Note that this function was formerly EC:4.1.3.7. subset: gosubset_prok synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1] synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1] synonym: "citrate synthase activity" BROAD [EC:2.3.3.1] synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1] synonym: "citric synthase activity" EXACT [EC:2.3.3.1] synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrogenase activity" EXACT [EC:2.3.3.1] synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1] synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1] synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1] xref: EC:2.3.3.1 xref: GO:0004108 xref: MetaCyc:CITSYN-RXN xref: Reactome:8157 is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0000581 name: coproporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O." [EC:1.3.3.3] subset: gosubset_prok synonym: "coprogen oxidase activity" EXACT [] synonym: "coproporphyrinogen-III oxidase activity" EXACT [] synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" EXACT [EC:1.3.3.3] synonym: "coproporphyrinogenase activity" EXACT [] xref: EC:1.3.3.3 xref: GO:0004109 xref: MetaCyc:RXN0-1461 xref: Reactome:8160 is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0000582 name: corticosteroid side-chain-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21] synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" EXACT [EC:5.3.1.21] synonym: "11-deoxycorticosterone ketol-isomerase activity" EXACT [EC:5.3.1.21] xref: EC:5.3.1.21 xref: GO:0004110 xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0000583 name: creatine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + creatine = ADP + phosphocreatine." [EC:2.7.3.2] synonym: "adenosine triphosphate-creatine transphosphorylase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine N-phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "BB-CK" RELATED [EC:2.7.3.2] synonym: "CK" RELATED [EC:2.7.3.2] synonym: "CK-BB" RELATED [EC:2.7.3.2] synonym: "CK-MB" RELATED [EC:2.7.3.2] synonym: "CK-MM" RELATED [EC:2.7.3.2] synonym: "CKMiMi" RELATED [EC:2.7.3.2] synonym: "creatine phosphokinase activity" EXACT [EC:2.7.3.2] synonym: "creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "MB-CK" RELATED [EC:2.7.3.2] synonym: "Mi-CK" RELATED [EC:2.7.3.2] synonym: "MiMi-CK" RELATED [EC:2.7.3.2] synonym: "MM-CK" RELATED [EC:2.7.3.2] synonym: "phosphocreatine kinase activity" EXACT [EC:2.7.3.2] xref: EC:2.7.3.2 xref: GO:0004111 xref: MetaCyc:CREATINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0000584 name: cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah] subset: gosubset_prok xref: EC:3.1.4.- xref: GO:0004112 is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0000585 name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37] subset: gosubset_prok synonym: "2',3'-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [] synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37] synonym: "2':3'-CNMP-3'-ase activity" EXACT [EC:3.1.4.37] synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "CNPase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37] synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37] xref: EC:3.1.4.37 xref: GO:0004113 xref: MetaCyc:3.1.4.37-RXN is_a: CCO:F0000584 ! cyclic-nucleotide phosphodiesterase activity [Term] id: CCO:F0000586 name: 3',5'-cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] subset: gosubset_prok synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-cyclonucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17] synonym: "cyclic nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.17] synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "PDE" RELATED [EC:3.1.4.17] xref: EC:3.1.4.17 xref: GO:0004114 xref: MetaCyc:3.1.4.17-RXN is_a: CCO:F0000584 ! cyclic-nucleotide phosphodiesterase activity [Term] id: CCO:F0000587 name: 3',5'-cyclic-AMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai] subset: gosubset_prok synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT [] synonym: "cAMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT [] xref: EC:3.1.4.- xref: GO:0004115 xref: Reactome:8212 is_a: CCO:F0000586 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: CCO:F0000588 name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah] xref: EC:3.1.4.- xref: GO:0004117 xref: Reactome:8219 is_a: CCO:F0000586 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: CCO:F0000589 name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4.- xref: GO:0004118 is_a: CCO:F0000586 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: CCO:F0000590 name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4.- xref: GO:0004119 is_a: CCO:F0000586 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: CCO:F0000591 name: photoreceptor cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of bonds in a cyclic nucleotide (nucleoside cyclic phosphate + H2O = nucleoside phosphate)." [EC:3.1.4.-] xref: EC:3.1.4.- xref: GO:0004120 is_a: CCO:F0000586 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: CCO:F0000592 name: cystathionine beta-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8] subset: gosubset_prok synonym: "beta C-S lyase activity" EXACT [EC:4.4.1.8] synonym: "beta-cystathionase activity" EXACT [EC:4.4.1.8] synonym: "cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "cystine lyase activity" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.8] xref: EC:4.4.1.8 xref: GO:0004121 xref: GO:0008799 xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0000593 name: cystathionine beta-synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] subset: gosubset_prok synonym: "beta-thionase activity" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine)" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [EC:4.2.1.22] synonym: "methylcysteine synthase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22] xref: EC:4.2.1.22 xref: GO:0004122 xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000594 name: cystathionine gamma-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate." [EC:4.4.1.1] subset: gosubset_prok synonym: "cystalysin" RELATED [EC:4.4.1.1] synonym: "cystathionase activity" EXACT [EC:4.4.1.1] synonym: "cystathioninase activity" EXACT [EC:4.4.1.1] synonym: "cysteine desulfhydrase activity" EXACT [] synonym: "cystine desulfhydrase activity" EXACT [EC:4.4.1.1] synonym: "gamma-CTL" RELATED [EC:4.4.1.1] synonym: "gamma-cystathionase activity" EXACT [EC:4.4.1.1] synonym: "homoserine deaminase activity" EXACT [EC:4.4.1.1] synonym: "homoserine deaminase-cystathionase activity" EXACT [EC:4.4.1.1] synonym: "homoserine dehydratase activity" EXACT [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating)" EXACT [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.1] xref: EC:4.4.1.1 xref: GO:0004123 xref: GO:0016225 xref: MetaCyc:CYSTAGLY-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0000595 name: cysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate." [EC:4.2.99.8] comment: Note that this function was formerly 4.2.99.8. subset: gosubset_prok synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47] xref: EC:2.5.1.47 xref: GO:0004124 xref: MetaCyc:ACSERLY-RXN is_a: CCO:F0003401 ! carbon-oxygen lyase activity [Term] id: CCO:F0000596 name: L-seryl-tRNASec selenium transferase activity namespace: molecular_function def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1] subset: gosubset_prok synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "cysteinyl-tRNASec-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNASel-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASec synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASel synthase activity" EXACT [EC:2.9.1.1] synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "selenocysteine synthase activity" EXACT [] synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT [] synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1] xref: EC:2.9.1.1 xref: GO:0004125 xref: MetaCyc:2.9.1.1-RXN is_a: CCO:F0003358 ! selenotransferase activity [Term] id: CCO:F0000597 name: cytidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5] subset: gosubset_prok synonym: "cytidine aminohydrolase activity" EXACT [EC:3.5.4.5] synonym: "cytosine nucleoside deaminase activity" EXACT [EC:3.5.4.5] xref: EC:3.5.4.5 xref: GO:0004126 xref: MetaCyc:CYTIDEAM2-RXN xref: Reactome:8270 is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0000598 name: cytidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14] subset: gosubset_prok synonym: "ATP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "ATP:UMP-CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "CMP kinase activity" NARROW [EC:2.7.4.14] synonym: "CTP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "cytidine monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14] synonym: "deoxycytidine monophosphokinase activity" EXACT [EC:2.7.4.14] synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14] synonym: "pyrimidine nucleoside monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "UMP-CMP kinase activity" EXACT [EC:2.7.4.14] xref: EC:2.7.4.14 xref: GO:0004127 xref: MetaCyc:CMPKI-RXN is_a: CCO:F0004124 ! nucleotide kinase activity [Term] id: CCO:F0000599 name: cytochrome-b5 reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684] synonym: "cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH 5alpha-reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome-b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-ferricytochrome b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] xref: EC:1.6.2.2 xref: GO:0004128 xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003251 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: CCO:F0000600 name: cytochrome-c oxidase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] subset: gosubset_prok synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1] synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1] synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1] synonym: "indophenol oxidase" NARROW [EC:1.9.3.1] synonym: "indophenolase" NARROW [EC:1.9.3.1] synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1] synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1] xref: EC:1.9.3.1 xref: GO:0004129 xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN xref: Reactome:8283 is_a: CCO:F0002522 ! heme-copper terminal oxidase activity is_a: CCO:F0002559 ! hydrogen ion transmembrane transporter activity is_a: CCO:F0003268 ! oxidoreductase activity, acting on heme group of donors, oxygen as acceptor [Term] id: CCO:F0000601 name: cytochrome-c peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5] subset: gosubset_prok synonym: "apocytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-551 peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-H2O oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome peroxidase activity" EXACT [EC:1.11.1.5] synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5] xref: EC:1.11.1.5 xref: GO:0004130 xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0000602 name: cytosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1] subset: gosubset_prok synonym: "cytosine aminohydrolase activity" EXACT [EC:3.5.4.1] synonym: "isocytosine deaminase activity" EXACT [EC:3.5.4.1] xref: EC:3.5.4.1 xref: GO:0004131 xref: MetaCyc:CYTDEAM-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0000603 name: dCMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12] subset: gosubset_prok synonym: "dCMP aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxy-CMP-deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine monophosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-phosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate deaminase activity" EXACT [EC:3.5.4.12] xref: EC:3.5.4.12 xref: GO:0004132 xref: MetaCyc:DCMP-DEAMINASE-RXN xref: Reactome:8340 is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0000604 name: glycogen debranching enzyme activity namespace: molecular_function def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok xref: GO:0004133 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0000605 name: 4-alpha-glucanotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan." [EC:2.4.1.25] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "amylomaltase activity" EXACT [EC:2.4.1.25] synonym: "D-enzyme activity" RELATED [EC:2.4.1.25] synonym: "debranching enzyme maltodextrin glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25] synonym: "dextrin transglycosylase activity" EXACT [EC:2.4.1.25] synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25] synonym: "oligo-1,4-1,4-glucantransferase activity" EXACT [EC:2.4.1.25] xref: EC:2.4.1.25 xref: GO:0004134 xref: MetaCyc:2.4.1.25-RXN xref: Reactome:8344 is_a: CCO:F0000604 ! glycogen debranching enzyme activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0000606 name: amylo-alpha-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the 1,6 glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amylo-1,6-glucosidase activity" EXACT [] synonym: "amylopectin 1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33] synonym: "dextrin-1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.33] xref: EC:3.2.1.33 xref: GO:0004135 xref: MetaCyc:3.2.1.33-RXN xref: Reactome:8347 is_a: CCO:F0000604 ! glycogen debranching enzyme activity is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0000607 name: deoxyadenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyadenosine = ADP + dAMP." [EC:2.7.1.76] subset: gosubset_prok synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.76] synonym: "deoxyadenosine kinase (phosphorylating)" EXACT [EC:2.7.1.76] synonym: "purine-deoxyribonucleoside kinase activity" EXACT [EC:2.7.1.76] xref: EC:2.7.1.76 xref: GO:0004136 xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN is_a: CCO:F0004072 ! deoxynucleoside kinase activity [Term] id: CCO:F0000608 name: deoxycytidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74] subset: gosubset_prok synonym: "2'-deoxycytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "Ara-C kinase activity" EXACT [EC:2.7.1.74] synonym: "arabinofuranosylcytosine kinase activity" EXACT [EC:2.7.1.74] synonym: "deoxycytidine kinase (phosphorylating)" EXACT [EC:2.7.1.74] synonym: "deoxycytidine-cytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.74] xref: EC:2.7.1.74 xref: GO:0004137 xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN is_a: CCO:F0004072 ! deoxynucleoside kinase activity [Term] id: CCO:F0000609 name: deoxyguanosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyguanosine = ADP + dGMP." [EC:2.7.1.113] subset: gosubset_prok synonym: "(dihydroxypropoxymethyl)guanine kinase activity" EXACT [EC:2.7.1.113] synonym: "2'-deoxyguanosine kinase activity" EXACT [EC:2.7.1.113] synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] synonym: "deoxyguanosine kinase (phosphorylating)" EXACT [EC:2.7.1.113] synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] xref: EC:2.7.1.113 xref: GO:0004138 xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN is_a: CCO:F0004072 ! deoxynucleoside kinase activity [Term] id: CCO:F0000610 name: deoxyribose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4] subset: gosubset_prok synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" EXACT [EC:4.1.2.4] synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" EXACT [EC:4.1.2.4] synonym: "2-deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4] synonym: "deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "phosphodeoxyriboaldolase activity" EXACT [EC:4.1.2.4] xref: EC:4.1.2.4 xref: GO:0004139 xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0000611 name: dephospho-CoA kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dephospho-CoA = ADP + CoA." [EC:2.7.1.24] subset: gosubset_prok synonym: "3'-dephospho-CoA kinase activity" EXACT [EC:2.7.1.24] synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase (phosphorylating)" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24] xref: EC:2.7.1.24 xref: GO:0004140 xref: MetaCyc:DEPHOSPHOCOAKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000612 name: dethiobiotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin." [EC:6.3.3.3] subset: gosubset_prok synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.3] synonym: "desthiobiotin synthase activity" EXACT [EC:6.3.3.3] synonym: "DTB synthetase activity" EXACT [EC:6.3.3.3] xref: EC:6.3.3.3 xref: GO:0004141 xref: MetaCyc:DETHIOBIOTIN-SYN-RXN is_a: CCO:F0003441 ! cyclo-ligase activity [Term] id: CCO:F0000613 name: diacylglycerol cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline diglyceride phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2] synonym: "CPT" RELATED [EC:2.7.8.2] synonym: "cytidine diphosphocholine glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "cytidine diphosphorylcholine diglyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "diacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphocholine diacylglyceroltransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphorylcholine--glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] xref: EC:2.7.8.2 xref: GO:0004142 xref: MetaCyc:2.7.8.2-RXN is_a: CCO:F0003607 ! CDP-alcohol phosphatidyltransferase activity [Term] id: CCO:F0000614 name: diacylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate." [EC:2.7.1.107] subset: gosubset_prok synonym: "1,2-diacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.107] synonym: "1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "arachidonoyl-specific diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.107] synonym: "ATP:diacylglycerol phosphotransferase activity" EXACT [EC:2.7.1.107] synonym: "DG kinase activity" EXACT [EC:2.7.1.107] synonym: "DGK activity" EXACT [EC:2.7.1.107] synonym: "diacylglycerol:ATP kinase activity" EXACT [EC:2.7.1.107] synonym: "diglyceride kinase activity" EXACT [EC:2.7.1.107] synonym: "sn-1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] xref: EC:2.7.1.107 xref: GO:0004143 xref: MetaCyc:DIACYLGLYKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000615 name: diacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] subset: gosubset_prok synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] xref: EC:2.3.1.20 xref: GO:0004144 xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: Reactome:8383 is_a: CCO:F0003134 ! acylglycerol O-acyltransferase activity [Term] id: CCO:F0000616 name: diamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57] subset: gosubset_prok synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW [] synonym: "diamine acetyltransferase activity" EXACT [] synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW [] synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57] synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermidine/spermine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermine acetyltransferase" NARROW [] synonym: "spermine N(1)-acetyltransferase" NARROW [] synonym: "spermine N-acetyltransferase" RELATED [] xref: EC:2.3.1.57 xref: GO:0004145 xref: MetaCyc:DIAMACTRANS-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0000617 name: dihydrofolate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3] subset: gosubset_prok synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.3] synonym: "7,8-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "DHFR" RELATED [EC:1.5.1.3] synonym: "dihydrofolate reductase:thymidylate synthase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolate reduction" EXACT [] synonym: "dihydrofolic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolic reductase activity" EXACT [EC:1.5.1.3] synonym: "folic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "folic reductase activity" EXACT [EC:1.5.1.3] synonym: "NADPH-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "pteridine reductase:dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "tetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.3] synonym: "thymidylate synthetase-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] xref: EC:1.5.1.3 xref: GO:0004146 xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000618 name: dihydrolipoamide branched chain acyltransferase activity namespace: molecular_function subset: gosubset_prok synonym: "dihydrolipoamide branched chain transacylase activity" EXACT [] xref: EC:2.3.1.- xref: GO:0004147 xref: Reactome:8394 is_a: CCO:F0004452 ! dihydrolipoamide S-acyltransferase activity [Term] id: CCO:F0000619 name: dihydrolipoyl dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] subset: gosubset_prok synonym: "dehydrolipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "diaphorase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4] synonym: "dihydrolipoamide:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "dihydrolipoic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4] synonym: "dihydrothioctic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4] synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4] synonym: "L-protein activity" RELATED [EC:1.8.1.4] synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4] synonym: "LDP-Val activity" NARROW [EC:1.8.1.4] synonym: "lipoamide dehydrogenase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide oxidoreductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase activity" EXACT [EC:1.8.1.4] synonym: "lipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoic acid dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoyl dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] xref: EC:1.8.1.4 xref: GO:0004148 xref: MetaCyc:DIHYDLIPOXN-RXN xref: Reactome:8399 is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000620 name: dihydrolipoyllysine-residue succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61] subset: gosubset_prok synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT [] synonym: "dihydrolipoamide succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipolyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase (Escherichia coli) activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "lipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] xref: EC:2.3.1.61 xref: GO:0004149 xref: MetaCyc:DIHYDLIPSUCCTRANS-RXN xref: Reactome:8404 is_a: CCO:F0003326 ! S-succinyltransferase activity [Term] id: CCO:F0000621 name: dihydroneopterin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25] subset: gosubset_prok synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" EXACT [EC:4.1.2.25] synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" EXACT [EC:4.1.2.25] xref: EC:4.1.2.25 xref: GO:0004150 xref: MetaCyc:H2NEOPTERINALDOL-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0000622 name: dihydroorotase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate." [EC:3.5.2.3] subset: gosubset_prok synonym: "(S)-dihydroorotate amidohydrolase activity" EXACT [EC:3.5.2.3] synonym: "carbamoylaspartic dehydrase activity" EXACT [EC:3.5.2.3] synonym: "DHOase activity" EXACT [EC:3.5.2.3] synonym: "dihydroorotate hydrolase activity" EXACT [EC:3.5.2.3] xref: EC:3.5.2.3 xref: GO:0004151 xref: MetaCyc:DIHYDROOROT-RXN xref: Reactome:8410 is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0000623 name: dihydroorotate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor." [EC:1.3.99.11] subset: gosubset_prok synonym: "(S)-dihydroorotate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.11] synonym: "(S)-dihydroorotate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.11] synonym: "dihydroorotate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.99.11] xref: EC:1.3.99.11 xref: GO:0004152 xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN xref: Reactome:8412 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0000624 name: dihydropterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydropterin + H20 = 7,8-dihydrolumazine + NH3." [GOC:jl, ISSN:05829879] xref: GO:0004153 is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0000625 name: dihydropterin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + H2O2." [GOC:mah, PMID:1745247, PMID:6815189] xref: EC:1.5.3.- xref: GO:0004154 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0000626 name: 6,7-dihydropteridine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34] comment: Note that this function was formerly EC:1.6.99.7. subset: gosubset_prok synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "DHPR activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase (NADH) activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase activity" EXACT [] synonym: "dihydropteridine reduction" RELATED [] synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NADH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-specific dihydropteridine reductase activity" EXACT [EC:1.5.1.34] xref: EC:1.5.1.34 xref: GO:0004155 xref: MetaCyc:1.5.1.34-RXN xref: Reactome:8421 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000627 name: dihydropteroate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15] subset: gosubset_prok synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroic acid synthetase activity" EXACT [EC:2.5.1.15] synonym: "DHPS activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate diphosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate pyrophosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroic synthetase activity" EXACT [EC:2.5.1.15] xref: EC:2.5.1.15 xref: GO:0004156 xref: MetaCyc:H2PTEROATESYNTH-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0000628 name: dihydropyrimidinase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2] subset: gosubset_prok synonym: "5,6-dihydropyrimidine amidohydrolase activity" EXACT [EC:3.5.2.2] synonym: "D-hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydantoin peptidase activity" EXACT [EC:3.5.2.2] synonym: "hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydropyrimidine hydrase activity" EXACT [EC:3.5.2.2] synonym: "pyrimidine hydrase activity" EXACT [EC:3.5.2.2] xref: EC:3.5.2.2 xref: GO:0004157 xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN xref: Reactome:8430 is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0000629 name: dihydroorotate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2." [EC:1.3.3.1] subset: gosubset_prok synonym: "(DHO) dehydrogenase activity" EXACT [EC:1.3.3.1] synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] synonym: "DHOdehase activity" EXACT [EC:1.3.3.1] synonym: "dihydoorotic acid dehydrogenase activity" EXACT [EC:1.3.3.1] xref: EC:1.3.3.1 xref: GO:0004158 xref: MetaCyc:DIHYDROOROTOX-RXN is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0000630 name: dihydrouracil dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+." [EC:1.3.1.1] synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.1] synonym: "dehydrogenase, dihydrouracil" EXACT [EC:1.3.1.1] synonym: "pyrimidine reductase activity" EXACT [EC:1.3.1.1] synonym: "thymine reductase activity" EXACT [EC:1.3.1.1] synonym: "uracil reductase activity" EXACT [EC:1.3.1.1] xref: EC:1.3.1.1 xref: GO:0004159 xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-(NAD+)-RXN xref: Reactome:8435 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000631 name: dihydroxy-acid dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9] subset: gosubset_prok synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxy-acid hydro-lyase activity" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "acetohydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "DHAD" RELATED [EC:4.2.1.9] synonym: "dihydroxy acid dehydrase activity" EXACT [EC:4.2.1.9] xref: EC:4.2.1.9 xref: GO:0004160 xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000632 name: dimethylallyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1] comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. subset: gosubset_prok synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyltransferase activity" EXACT [] synonym: "diprenyltransferase activity" EXACT [EC:2.5.1.1] synonym: "DMAPP:IPP-dimethylallyltransferase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1] synonym: "trans-farnesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] xref: EC:2.5.1.1 xref: GO:0004161 xref: MetaCyc:GPPSYN-RXN is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0000633 name: dimethylnitrosamine demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah] synonym: "N-nitrosodimethylamine demethylase activity" EXACT [] xref: GO:0004162 is_a: CCO:F0004997 ! demethylase activity [Term] id: CCO:F0000634 name: diphosphomevalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2." [EC:4.1.1.33] subset: gosubset_prok synonym: "5-pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" EXACT [EC:4.1.1.33] synonym: "mevalonate 5-diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate-5-pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonic acid decarboxylase activity" EXACT [EC:4.1.1.33] xref: EC:4.1.1.33 xref: GO:0004163 xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN xref: Reactome:8449 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000635 name: diphthine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98] subset: gosubset_prok synonym: "diphthine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" EXACT [EC:2.1.1.98] xref: EC:2.1.1.98 xref: GO:0004164 xref: MetaCyc:DIPHTHINE-SYNTHASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0000636 name: dodecenoyl-CoA delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] subset: gosubset_prok synonym: "3,2-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "acetylene-allene isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3),Delta(2)-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3,Delta2-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.8] synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA D-isomerase activity" EXACT [] synonym: "dodecenoyl-CoA Delta-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] xref: EC:5.3.3.8 xref: GO:0004165 xref: GO:0008461 xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN xref: Reactome:8459 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0000637 name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153] synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] xref: EC:2.4.1.153 xref: GO:0004101 xref: GO:0004166 xref: MetaCyc:2.4.1.153-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0000638 name: dopachrome isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12] synonym: "DCF activity" EXACT [EC:5.3.3.12] synonym: "DCT activity" EXACT [EC:5.3.3.12] synonym: "dopachrome conversion activity" BROAD [] synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12] synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome delta-isomerase activity" EXACT [] synonym: "dopachrome delta7,Delta2-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome oxidoreductase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome rearranging enzyme activity" EXACT [EC:5.3.3.12] synonym: "dopachrome tautomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12] synonym: "L-dopachrome isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome-methyl ester tautomerase activity" EXACT [EC:5.3.3.12] synonym: "TRP activity" EXACT [EC:5.3.3.12] synonym: "TRP-1" RELATED [EC:5.3.3.12] synonym: "TRP-2" RELATED [EC:5.3.3.12] synonym: "TRP2" RELATED [EC:5.3.3.12] synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12] synonym: "tyrosinase-related protein 2 activity" EXACT [EC:5.3.3.12] xref: EC:5.3.3.12 xref: GO:0004167 xref: GO:0048059 xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0000639 name: dolichol kinase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108] synonym: "CTP:dolichol O-phosphotransferase activity" EXACT [EC:2.7.1.108] synonym: "dolichol phosphokinase activity" EXACT [EC:2.7.1.108] xref: EC:2.7.1.108 xref: GO:0004168 xref: MetaCyc:DOLICHOL-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000640 name: dolichyl-phosphate-mannose-protein mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109] subset: gosubset_prok synonym: "dolichol phosphomannose-protein mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT [] synonym: "O-glycoside mannosyltransferase" BROAD [] synonym: "protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "protein O-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.109 xref: GO:0004169 xref: MetaCyc:2.4.1.109-RXN is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0000641 name: dUTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23] subset: gosubset_prok synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP pyrophosphatase activity" EXACT [] synonym: "dUTPase activity" EXACT [EC:3.6.1.23] xref: EC:3.6.1.23 xref: GO:0004170 xref: MetaCyc:DUTP-PYROP-RXN xref: Reactome:8479 is_a: CCO:F0006737 ! nucleoside-triphosphate diphosphatase activity [Term] id: CCO:F0000642 name: ecdysone O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + ecdysone = CoA + ecdysone palmitate." [EC:2.3.1.139] synonym: "acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" EXACT [EC:2.3.1.139] xref: EC:2.3.1.139 xref: GO:0004173 xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0000643 name: electron-transferring-flavoprotein dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1] subset: gosubset_prok synonym: "electron transfer flavoprotein dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein Q oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein reductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "ETF-QO activity" EXACT [EC:1.5.5.1] synonym: "ETF-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] xref: EC:1.5.5.1 xref: GO:0004174 xref: MetaCyc:1.5.5.1-RXN xref: Reactome:8494 is_a: CCO:F0003248 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor [Term] id: CCO:F0000644 name: endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "endoprotease activity" EXACT [] synonym: "proteasome endopeptidase activity" NARROW [] synonym: "proteasome endopeptidase regulator" RELATED [] synonym: "proteinase" BROAD [] xref: GO:0004175 xref: GO:0016809 xref: Reactome:1793 is_a: CCO:F0001783 ! peptidase activity [Term] id: CCO:F0000645 name: ATP-dependent peptidase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds." [GOC:mah] subset: gosubset_prok xref: GO:0004176 xref: GO:0004280 is_a: CCO:F0001783 ! peptidase activity [Term] id: CCO:F0000646 name: aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal amino acid residues from oligopeptides or polypeptides." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.4.11 xref: GO:0004177 is_a: CCO:F0001788 ! exopeptidase activity [Term] id: CCO:F0000647 name: leucyl aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1] subset: gosubset_prok synonym: "aminopeptidase II" RELATED [EC:3.4.11.1] synonym: "cathepsin III" RELATED [EC:3.4.11.1] synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1] synonym: "FTBL proteins" RELATED [EC:3.4.11.1] synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1] synonym: "peptidase S activity" NARROW [EC:3.4.11.1] synonym: "proteinates FTBL" RELATED [EC:3.4.11.1] xref: EC:3.4.11.1 xref: GO:0004178 xref: MetaCyc:3.4.11.1-RXN is_a: CCO:F0000646 ! aminopeptidase activity is_a: CCO:F0001785 ! metalloexopeptidase activity [Term] id: CCO:F0000648 name: membrane alanyl aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2] subset: gosubset_prok synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2] synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2] synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2] synonym: "CD13" RELATED [EC:3.4.11.2] synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2] synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2] synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2] synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "peptidase E activity" BROAD [EC:3.4.11.2] synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2] xref: EC:3.4.11.2 xref: GO:0004179 xref: MetaCyc:3.4.11.2-RXN is_a: CCO:F0001785 ! metalloexopeptidase activity is_a: CCO:F0003101 ! alanine aminopeptidase activity [Term] id: CCO:F0000649 name: carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolytic cleavage of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0004180 is_a: CCO:F0001788 ! exopeptidase activity [Term] id: CCO:F0000650 name: metallocarboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.4.17 xref: GO:0004181 is_a: CCO:F0000649 ! carboxypeptidase activity is_a: CCO:F0001785 ! metalloexopeptidase activity [Term] id: CCO:F0000651 name: carboxypeptidase A activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1] subset: gosubset_prok synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1] synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1] synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1] xref: EC:3.4.17.1 xref: GO:0004182 xref: GO:0008731 xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0000652 name: carboxypeptidase E activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10] synonym: "carboxypeptidase H activity" EXACT [] synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10] synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10] synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10] xref: EC:3.4.17.10 xref: GO:0004183 xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0000653 name: lysine carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3] synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3] synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "bradykinase activity" EXACT [EC:3.4.17.3] synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3] synonym: "carboxypeptidase N activity" EXACT [] synonym: "CPase N" RELATED [EC:3.4.17.3] synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3] synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3] synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3] synonym: "kininase I activity" EXACT [EC:3.4.17.3] synonym: "kininase Ia" RELATED [EC:3.4.17.3] synonym: "lysine (arginine) carboxypeptidase activity" EXACT [] synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3] synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3] xref: EC:3.4.17.3 xref: GO:0004184 xref: MetaCyc:LYSINE(ARGININE)-CARBOXYPEPTIDASE-RXN is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0000654 name: serine carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [EC:3.4.16.-, http://en.wikipedia.org/wiki/Serine_hydrolase] subset: gosubset_prok xref: EC:3.4.16 xref: GO:0004185 xref: Reactome:8533 is_a: CCO:F0000649 ! carboxypeptidase activity is_a: CCO:F0001786 ! serine-type peptidase activity [Term] id: CCO:F0000655 name: carboxypeptidase C activity namespace: molecular_function def: "Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] synonym: "carboxypeptidase Y activity" EXACT [EC:3.4.16.5] synonym: "cathepsin A activity" NARROW [EC:3.4.16.5] synonym: "deamidase" RELATED [EC:3.4.16.5] synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5] synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5] synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "vacuolar carboxypeptidase Y" NARROW [] xref: EC:3.4.16.5 xref: GO:0004186 xref: MetaCyc:3.4.16.5-RXN is_a: CCO:F0000654 ! serine carboxypeptidase activity [Term] id: CCO:F0000656 name: carboxypeptidase D activity namespace: molecular_function def: "Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6] synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6] synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6] synonym: "carboxypeptidase S1 activity" EXACT [EC:3.4.16.6] synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6] synonym: "CPDW-II" RELATED [EC:3.4.16.6] synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6] synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6] synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6] synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6] synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6] xref: EC:3.4.16.6 xref: GO:0004187 xref: MetaCyc:3.4.16.6-RXN is_a: CCO:F0000654 ! serine carboxypeptidase activity [Term] id: CCO:F0000657 name: serine-type Pro-X carboxypeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2] synonym: "aminoacylproline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW [] synonym: "lysosomal Pro-Xaa carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "PCP" RELATED [EC:3.4.16.2] synonym: "peptidylprolylamino acid carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2] synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2] xref: EC:3.4.16.2 xref: GO:0004188 xref: GO:0008323 xref: MetaCyc:3.4.16.2-RXN is_a: CCO:F0000654 ! serine carboxypeptidase activity is_a: CCO:F0001834 ! Pro-X carboxypeptidase activity [Term] id: CCO:F0000658 name: tubulinyl-Tyr carboxypeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17] synonym: "brain I carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "carboxypeptidase-tubulin activity" EXACT [EC:3.4.17.17] synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17] synonym: "TTCPase activity" EXACT [EC:3.4.17.17] synonym: "tubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulin-tyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT [] synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] xref: EC:3.4.17.17 xref: GO:0004189 xref: MetaCyc:3.4.17.17-RXN is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0000659 name: aspartic-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aspartic endopeptidase activity" EXACT [] synonym: "aspartic protease activity" EXACT [] synonym: "aspartyl protease activity" EXACT [] synonym: "carboxyl protease activity" EXACT [] xref: EC:3.4.23 xref: GO:0004190 xref: Reactome:1933 is_a: CCO:F0000644 ! endopeptidase activity [Term] id: CCO:F0000660 name: barrierpepsin activity namespace: molecular_function def: "Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35] synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35] synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35] synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35] xref: EC:3.4.23.35 xref: GO:0004191 xref: MetaCyc:3.4.23.35-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0000661 name: cathepsin D activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5] xref: EC:3.4.23.5 xref: GO:0004192 xref: MetaCyc:3.4.23.5-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0000662 name: cathepsin E activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34] synonym: "cathepsin D-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin D-type proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin E-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "EMAP" RELATED [EC:3.4.23.34] synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34] synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34] synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34] synonym: "SMP" RELATED [EC:3.4.23.34] xref: EC:3.4.23.34 xref: GO:0004193 xref: MetaCyc:3.4.23.34-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0000663 name: pepsin A activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1] synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1] synonym: "fundus-pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1] synonym: "P I" RELATED [EC:3.4.23.1] synonym: "P II" RELATED [EC:3.4.23.1] synonym: "pepsin activity" BROAD [EC:3.4.23.1] synonym: "pepsin D" RELATED [EC:3.4.23.1] synonym: "pepsin fortior" RELATED [EC:3.4.23.1] synonym: "pepsin R" RELATED [EC:3.4.23.1] xref: EC:3.4.23.1 xref: GO:0004194 xref: MetaCyc:3.4.23.1-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0000664 name: renin activity namespace: molecular_function def: "Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15] synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15] synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15] xref: EC:3.4.23.15 xref: GO:0004195 xref: MetaCyc:3.4.23.15-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0000665 name: saccharopepsin activity namespace: molecular_function def: "Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25] synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25] synonym: "PRA" RELATED [EC:3.4.23.25] synonym: "proteinase A" RELATED [EC:3.4.23.25] synonym: "proteinase yscA" RELATED [EC:3.4.23.25] synonym: "saccharomyces aspartic proteinase activity" EXACT [EC:3.4.23.25] synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25] synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25] synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25] synonym: "yeast proteinase A" RELATED [EC:3.4.23.25] xref: EC:3.4.23.25 xref: GO:0004196 xref: MetaCyc:3.4.23.25-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0000666 name: cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center." [EC:3.4.22.-, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lysosomal cysteine-type endopeptidase" NARROW [] synonym: "thiol endopeptidase activity" EXACT [] xref: EC:3.4.22 xref: GO:0004197 is_a: CCO:F0000644 ! endopeptidase activity is_a: CCO:F0001784 ! cysteine-type peptidase activity [Term] id: CCO:F0000667 name: calcium-dependent cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] subset: gosubset_prok synonym: "calpain activity" NARROW [] xref: GO:0004198 is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0000668 name: cathepsin B activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1] synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1] synonym: "cathepsin II" RELATED [EC:3.4.22.1] xref: EC:3.4.22.1 xref: GO:0004213 xref: MetaCyc:3.4.22.1-RXN is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0000669 name: dipeptidyl-peptidase I activity namespace: molecular_function def: "Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1] synonym: "cathepsin C activity" EXACT [EC:3.4.14.1] synonym: "cathepsin J activity" EXACT [EC:3.4.14.1] synonym: "DAP I" RELATED [EC:3.4.14.1] synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1] synonym: "dipeptidyl aminopeptidase I activity" EXACT [EC:3.4.14.1] synonym: "dipeptidyl transferase activity" EXACT [EC:3.4.14.1] xref: EC:3.4.14.1 xref: GO:0004214 xref: MetaCyc:3.4.14.1-RXN is_a: CCO:F0001784 ! cysteine-type peptidase activity is_a: CCO:F0001789 ! dipeptidyl-peptidase activity [Term] id: CCO:F0000670 name: cathepsin H activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16] synonym: "aleurain activity" EXACT [EC:3.4.22.16] synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" EXACT [EC:3.4.22.16] synonym: "cathepsin B3 activity" EXACT [EC:3.4.22.16] synonym: "cathepsin Ba" RELATED [EC:3.4.22.16] synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16] synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16] xref: EC:3.4.22.16 xref: GO:0004215 xref: MetaCyc:3.4.22.16-RXN is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0000671 name: cathepsin K activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38] synonym: "cathepsin O activity" EXACT [EC:3.4.22.38] synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38] synonym: "cathepsin X activity" EXACT [EC:3.4.22.38] xref: EC:3.4.22.38 xref: GO:0004216 xref: MetaCyc:3.4.22.38-RXN is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0000672 name: cathepsin L activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15] synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15] xref: EC:3.4.22.15 xref: GO:0004217 xref: MetaCyc:3.4.22.15-RXN is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0000673 name: cathepsin S activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27] xref: EC:3.4.22.27 xref: GO:0004218 xref: MetaCyc:3.4.22.27-RXN is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0000674 name: pyroglutamyl-peptidase I activity namespace: molecular_function def: "Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3] comment: Note that pyroglutamic acid has sometimes been referred to as 5-oxoproline. subset: gosubset_prok synonym: "5-oxoprolyl-peptidase activity" EXACT [EC:3.4.19.3] synonym: "L-pyroglutamyl peptide hydrolase activity" EXACT [EC:3.4.19.3] synonym: "L-pyrrolidonecarboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrase activity" EXACT [EC:3.4.19.3] synonym: "PYRase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamyl aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonecarboxylyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonyl peptidase activity" EXACT [EC:3.4.19.3] xref: EC:3.4.19.3 xref: GO:0004219 xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN is_a: CCO:F0001784 ! cysteine-type peptidase activity is_a: CCO:F0003470 ! pyroglutamyl-peptidase activity [Term] id: CCO:F0000675 name: ubiquitin thiolesterase activity namespace: molecular_function def: "Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15] subset: gosubset_prok synonym: "isopeptidase activity" EXACT [EC:3.1.2.15] synonym: "isopeptidase T" RELATED [EC:3.1.2.15] synonym: "ubiquitin C-terminal hydrolase activity" EXACT [] synonym: "ubiquitin carboxy-terminal esterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin carboxy-terminal hydrolase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin thioesterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin-C-terminal-thioester hydrolase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitinyl hydrolase 1 activity" NARROW [] xref: EC:3.1.2.15 xref: GO:0004221 xref: GO:0008577 xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN is_a: CCO:F0001199 ! ubiquitin-specific protease activity is_a: CCO:F0003361 ! thiolester hydrolase activity [Term] id: CCO:F0000676 name: metalloendopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "metalloprotease" BROAD [] synonym: "metalloproteinase" BROAD [] xref: EC:3.4.24 xref: GO:0004222 xref: Reactome:1791 is_a: CCO:F0000644 ! endopeptidase activity is_a: CCO:F0001787 ! metallopeptidase activity [Term] id: CCO:F0000677 name: Gly-X carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4] subset: gosubset_prok synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4] synonym: "carboxypeptidase S activity" EXACT [EC:3.4.17.4] synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "peptidase alpha" RELATED [EC:3.4.17.4] synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4] xref: EC:3.4.17.4 xref: GO:0004226 xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0000678 name: gelatinase A activity namespace: molecular_function def: "Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24] synonym: "3/4 collagenase activity" EXACT [EC:3.4.24.24] synonym: "72 kDa gelatinase type A" RELATED [EC:3.4.24.24] synonym: "72-kDa gelatinase activity" NARROW [EC:3.4.24.24] synonym: "collagenase IV" RELATED [EC:3.4.24.24] synonym: "collagenase type IV" RELATED [EC:3.4.24.24] synonym: "matrix metalloproteinase 2 activity" EXACT [EC:3.4.24.24] synonym: "matrix metalloproteinase 5" RELATED [EC:3.4.24.24] synonym: "MMP 2" RELATED [EC:3.4.24.24] synonym: "MMP-2" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24] synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24] synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24] xref: EC:3.4.24.24 xref: GO:0004228 xref: MetaCyc:3.4.24.24-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000679 name: gelatinase B activity namespace: molecular_function def: "Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35] synonym: "92-kDa gelatinase activity" NARROW [EC:3.4.24.35] synonym: "92-kDa type IV collagenase activity" NARROW [EC:3.4.24.35] synonym: "95 kDa type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.35] synonym: "collagenase IV" RELATED [EC:3.4.24.35] synonym: "collagenase type IV" RELATED [EC:3.4.24.35] synonym: "gelatinase MMP 9" RELATED [EC:3.4.24.35] synonym: "macrophage gelatinase activity" NARROW [EC:3.4.24.35] synonym: "matrix metalloproteinase 9 activity" EXACT [EC:3.4.24.35] synonym: "MMP 9" RELATED [EC:3.4.24.35] synonym: "MMP-9" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35] synonym: "type V collagenase activity" EXACT [EC:3.4.24.35] xref: EC:3.4.24.35 xref: GO:0004229 xref: MetaCyc:3.4.24.35-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000680 name: glutamyl aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7] subset: gosubset_prok synonym: "aminopeptidase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A2" RELATED [EC:3.4.11.7] synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7] synonym: "aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "Ca2+-activated glutamate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "glutamyl peptidase activity" EXACT [EC:3.4.11.7] synonym: "L-aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7] xref: EC:3.4.11.7 xref: GO:0004230 xref: MetaCyc:3.4.11.7-RXN is_a: CCO:F0000646 ! aminopeptidase activity is_a: CCO:F0001785 ! metalloexopeptidase activity [Term] id: CCO:F0000681 name: insulysin activity namespace: molecular_function def: "Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56] subset: gosubset_prok synonym: "IDE" RELATED [EC:3.4.24.56] synonym: "insulin protease activity" EXACT [EC:3.4.24.56] synonym: "insulin proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading enzyme activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading neutral proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-glucagon protease activity" EXACT [EC:3.4.24.56] synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56] synonym: "insulinase activity" EXACT [EC:3.4.24.56] synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56] xref: EC:3.4.24.56 xref: GO:0004231 xref: MetaCyc:3.4.24.56-RXN xref: Reactome:9609 is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000682 name: interstitial collagenase activity namespace: molecular_function def: "Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7] synonym: "matrix metalloproteinase 1" EXACT [] synonym: "MMP-1" EXACT [] synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7] xref: EC:3.4.24.7 xref: GO:0004232 xref: MetaCyc:3.4.24.7-RXN is_a: CCO:F0001737 ! collagenase activity [Term] id: CCO:F0000683 name: macrophage elastase activity namespace: molecular_function def: "Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65] synonym: "human macrophage metalloelastase (HME)" EXACT [EC:3.4.24.65] synonym: "matrix metalloproteinase 12 activity" EXACT [EC:3.4.24.65] synonym: "metalloelastase activity" EXACT [EC:3.4.24.65] synonym: "metalloesterase activity" EXACT [] synonym: "MMP-12" EXACT [] xref: EC:3.4.24.65 xref: GO:0004234 xref: MetaCyc:3.4.24.65-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity is_a: CCO:F0005704 ! elastase activity [Term] id: CCO:F0000684 name: matrilysin activity namespace: molecular_function def: "Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23] synonym: "matrin activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase 7 activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase pump 1" RELATED [EC:3.4.24.23] synonym: "metalloproteinase pump-1" RELATED [EC:3.4.24.23] synonym: "MMP" RELATED [EC:3.4.24.23] synonym: "MMP 7" RELATED [EC:3.4.24.23] synonym: "MMP-7" EXACT [] synonym: "PUMP" RELATED [EC:3.4.24.23] synonym: "PUMP-1 activity" NARROW [EC:3.4.24.23] synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23] synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23] synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23] synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23] xref: EC:3.4.24.23 xref: GO:0004235 xref: MetaCyc:3.4.24.23-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000685 name: membrane dipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19] subset: gosubset_prok synonym: "aminodipeptidase activity" EXACT [EC:3.4.13.19] synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19] synonym: "dehydropeptidase I activity" EXACT [EC:3.4.13.19] synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19] synonym: "dipeptidyl hydrolase activity" EXACT [EC:3.4.13.19] synonym: "DPH I activity" NARROW [EC:3.4.13.19] synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "MDP" RELATED [EC:3.4.13.19] synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19] synonym: "nonspecific dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19] xref: EC:3.4.13.19 xref: GO:0004237 xref: MetaCyc:3.4.13.19-RXN is_a: CCO:F0001785 ! metalloexopeptidase activity is_a: CCO:F0003375 ! dipeptidase activity [Term] id: CCO:F0000686 name: meprin A activity namespace: molecular_function def: "Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18] synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.18] synonym: "meprin" RELATED [EC:3.4.24.18] synonym: "meprin-a" RELATED [EC:3.4.24.18] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PPH" RELATED [EC:3.4.24.18] xref: EC:3.4.24.18 xref: GO:0004238 xref: MetaCyc:3.4.24.18-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000687 name: methionyl aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18] subset: gosubset_prok synonym: "L-methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "MAP" RELATED [EC:3.4.11.18] synonym: "methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "peptidase M activity" EXACT [EC:3.4.11.18] xref: EC:3.4.11.18 xref: GO:0004239 xref: MetaCyc:3.4.11.18-RXN is_a: CCO:F0000646 ! aminopeptidase activity is_a: CCO:F0001785 ! metalloexopeptidase activity [Term] id: CCO:F0000688 name: mitochondrial processing peptidase activity namespace: molecular_function def: "Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64] synonym: "alpha-mitochondrial processing peptidase" NARROW [] synonym: "beta-mitochondrial processing peptidase" NARROW [] synonym: "matrix peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing proteinase" RELATED [EC:3.4.24.64] synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT [EC:3.4.24.64] synonym: "MPP" EXACT [] synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64] synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64] xref: EC:3.4.24.64 xref: GO:0004240 xref: MetaCyc:3.4.24.64-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity is_a: CCO:F0002335 ! signal peptidase activity [Term] id: CCO:F0000689 name: mitochondrial intermediate peptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59] synonym: "MIP" BROAD [] synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59] xref: EC:3.4.24.59 xref: GO:0004243 xref: MetaCyc:3.4.24.59-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000690 name: mitochondrial inner membrane peptidase activity namespace: molecular_function def: "Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769] synonym: "IMP" BROAD [] xref: EC:3.4.99.- xref: GO:0004244 is_a: CCO:F0000644 ! endopeptidase activity [Term] id: CCO:F0000691 name: neprilysin activity namespace: molecular_function def: "Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11] subset: gosubset_prok synonym: "acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "CALLA" RELATED [EC:3.4.24.11] synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [EC:3.4.24.11] synonym: "CALLA antigen" RELATED [EC:3.4.24.11] synonym: "CALLA glycoprotein" RELATED [EC:3.4.24.11] synonym: "CALLA glycoproteins" RELATED [EC:3.4.24.11] synonym: "CD10" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [EC:3.4.24.11] synonym: "endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.11] synonym: "enkephalinase activity" EXACT [EC:3.4.24.11] synonym: "kidney-brush-border neutral endopeptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral peptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral proteinase activity" NARROW [EC:3.4.24.11] synonym: "membrane metalloendopeptidase activity" NARROW [EC:3.4.24.11] synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11] synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11] xref: EC:3.4.24.11 xref: GO:0004245 xref: MetaCyc:3.4.24.11-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000692 name: peptidyl-dipeptidase A activity namespace: molecular_function def: "Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1] subset: gosubset_prok synonym: "ACE activity" BROAD [] synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1] synonym: "angiotensin I-converting enzyme activity" EXACT [EC:3.4.15.1] synonym: "carboxycathepsin activity" EXACT [EC:3.4.15.1] synonym: "DCP" RELATED [EC:3.4.15.1] synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1] synonym: "dipeptidyl carboxypeptidase I activity" EXACT [EC:3.4.15.1] synonym: "endothelial cell peptidyl dipeptidase activity" EXACT [EC:3.4.15.1] synonym: "kininase II activity" EXACT [EC:3.4.15.1] synonym: "PDH" RELATED [EC:3.4.15.1] synonym: "peptidase P activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptidase I activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyl-dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyldipeptide hydrolase activity" EXACT [EC:3.4.15.1] xref: EC:3.4.15.1 xref: GO:0004246 xref: MetaCyc:3.4.15.1-RXN is_a: CCO:F0001787 ! metallopeptidase activity is_a: CCO:F0001791 ! peptidyl-dipeptidase activity [Term] id: CCO:F0000693 name: saccharolysin activity namespace: molecular_function def: "Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [EC:3.4.24.37] synonym: "oligopeptidase yscD activity" NARROW [EC:3.4.24.37] synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37] synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37] synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37] xref: EC:3.4.24.37 xref: GO:0004247 xref: MetaCyc:3.4.24.37-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000694 name: stromelysin 1 activity namespace: molecular_function def: "Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17] synonym: "collagen-activating protein" RELATED [EC:3.4.24.17] synonym: "collagenase activating protein" RELATED [EC:3.4.24.17] synonym: "matrix metalloproteinase 3 activity" EXACT [EC:3.4.24.17] synonym: "MMP-3" EXACT [] synonym: "neutral proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "procollagenase activator" RELATED [EC:3.4.24.17] synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "stromelysin" RELATED [EC:3.4.24.17] synonym: "transin activity" EXACT [EC:3.4.24.17] xref: EC:3.4.24.17 xref: GO:0004248 xref: MetaCyc:3.4.24.17-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000695 name: stromelysin 3 activity namespace: molecular_function synonym: "matrix metalloproteinase 11" EXACT [] synonym: "MMP-11" EXACT [] xref: EC:3.4.24.- xref: GO:0004249 is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0000696 name: aminopeptidase I activity namespace: molecular_function def: "Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22] subset: gosubset_prok synonym: "aminopeptidase III activity" EXACT [EC:3.4.11.22] synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22] synonym: "leucine aminopeptidase IV activity" EXACT [EC:3.4.11.22] synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22] synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22] xref: EC:3.4.11.22 xref: GO:0004250 xref: MetaCyc:3.4.11.22-RXN is_a: CCO:F0000646 ! aminopeptidase activity is_a: CCO:F0001785 ! metalloexopeptidase activity [Term] id: CCO:F0000697 name: X-Pro dipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9] subset: gosubset_prok synonym: "gamma-peptidase activity" EXACT [EC:3.4.13.9] synonym: "imidodipeptidase activity" EXACT [EC:3.4.13.9] synonym: "peptidase D" RELATED [EC:3.4.13.9] synonym: "prolidase activity" EXACT [EC:3.4.13.9] synonym: "proline dipeptidase activity" EXACT [EC:3.4.13.9] synonym: "Xaa-Pro dipeptidase activity" EXACT [] xref: EC:3.4.13.9 xref: GO:0004251 xref: MetaCyc:3.4.13.9-RXN is_a: CCO:F0001785 ! metalloexopeptidase activity is_a: CCO:F0003375 ! dipeptidase activity [Term] id: CCO:F0000698 name: serine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://en.wikipedia.org/wiki/Serine_hydrolase, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "blood coagulation factor activity" RELATED [] xref: EC:3.4.21 xref: GO:0004252 xref: Reactome:1683 is_a: CCO:F0000644 ! endopeptidase activity is_a: CCO:F0001786 ! serine-type peptidase activity [Term] id: CCO:F0000699 name: gamma-renin activity namespace: molecular_function def: "Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54] xref: EC:3.4.21.54 xref: GO:0004253 xref: MetaCyc:3.4.21.54-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000700 name: acylaminoacyl-peptidase activity namespace: molecular_function def: "Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1] subset: gosubset_prok synonym: "acylamino-acid-releasing enzyme activity" EXACT [EC:3.4.19.1] synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1] xref: EC:3.4.19.1 xref: GO:0004254 xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000701 name: cathepsin G activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20] synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20] synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20] xref: EC:3.4.21.20 xref: GO:0004261 xref: MetaCyc:3.4.21.20-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000702 name: cerevisin activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48] synonym: "baker's yeast proteinase B" RELATED [EC:3.4.21.48] synonym: "brewer's yeast proteinase" NARROW [EC:3.4.21.48] synonym: "peptidase beta" RELATED [EC:3.4.21.48] synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48] synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48] xref: EC:3.4.21.48 xref: GO:0004262 xref: MetaCyc:3.4.21.48-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000703 name: chymotrypsin activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alpha-chymar" RELATED [EC:3.4.21.1] synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin A" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin activity" NARROW [EC:3.4.21.1] synonym: "avazyme" RELATED [EC:3.4.21.1] synonym: "chymar" RELATED [EC:3.4.21.1] synonym: "chymotest" RELATED [EC:3.4.21.1] synonym: "chymotrypsin A activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsin B activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1] synonym: "enzeon" RELATED [EC:3.4.21.1] synonym: "quimar" RELATED [EC:3.4.21.1] synonym: "quimotrase activity" EXACT [EC:3.4.21.1] xref: EC:3.4.21.1 xref: GO:0004263 xref: MetaCyc:3.4.21.1-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000704 name: dipeptidyl-peptidase IV activity namespace: molecular_function def: "Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5] subset: gosubset_prok synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-peptide hydrolase activity" EXACT [EC:3.4.14.5] synonym: "DPP IV activity" EXACT [EC:3.4.14.5] synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5] synonym: "Gly-Pro naphthylamidase activity" EXACT [EC:3.4.14.5] synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5] synonym: "glycylproline aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "pep X" RELATED [EC:3.4.14.5] synonym: "post-proline dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5] synonym: "X-PDAP" RELATED [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] xref: EC:3.4.14.5 xref: GO:0004274 xref: MetaCyc:3.4.14.5-RXN is_a: CCO:F0001786 ! serine-type peptidase activity is_a: CCO:F0001789 ! dipeptidyl-peptidase activity [Term] id: CCO:F0000705 name: enteropeptidase activity namespace: molecular_function def: "Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [EC:3.4.21.9] synonym: "enterokinase activity" RELATED [EC:3.4.21.9] xref: EC:3.4.21.9 xref: GO:0004275 xref: MetaCyc:3.4.21.9-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000706 name: furin activity namespace: molecular_function def: "Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75] synonym: "dibasic processing enzyme activity" EXACT [EC:3.4.21.75] synonym: "PACE" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid cleaving enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid converting enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.4.21.75] synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75] synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75] synonym: "SPC3" RELATED [EC:3.4.21.75] xref: EC:3.4.21.75 xref: GO:0004276 xref: MetaCyc:3.4.21.75-RXN xref: Reactome:9708 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000707 name: granzyme A activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78] synonym: "CTLA3" RELATED [EC:3.4.21.78] synonym: "cytotoxic T lymphocyte serine protease" NARROW [EC:3.4.21.78] synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [EC:3.4.21.78] synonym: "HuTPS" RELATED [EC:3.4.21.78] synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78] synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78] synonym: "TSP-1" RELATED [EC:3.4.21.78] xref: EC:3.4.21.78 xref: GO:0004277 xref: MetaCyc:3.4.21.78-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000708 name: granzyme B activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79] synonym: "CCP1 proteinase" NARROW [EC:3.4.21.79] synonym: "CCPII" RELATED [EC:3.4.21.79] synonym: "CTLA1" RELATED [EC:3.4.21.79] synonym: "cytotoxic cell proteinase-1" RELATED [EC:3.4.21.79] synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79] synonym: "granzyme G" RELATED [EC:3.4.21.79] synonym: "granzyme H" RELATED [EC:3.4.21.79] xref: EC:3.4.21.79 xref: GO:0004278 xref: MetaCyc:3.4.21.79-RXN xref: Reactome:9714 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000709 name: pancreatic elastase II activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71] synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71] xref: EC:3.4.21.71 xref: GO:0004281 xref: MetaCyc:3.4.21.71-RXN is_a: CCO:F0001736 ! pancreatic elastase activity [Term] id: CCO:F0000710 name: plasmin activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7] synonym: "actase activity" EXACT [EC:3.4.21.7] synonym: "fibrinase activity" EXACT [EC:3.4.21.7] synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7] synonym: "serum tryptase activity" EXACT [EC:3.4.21.7] synonym: "thrombolysin" RELATED [EC:3.4.21.7] xref: EC:3.4.21.7 xref: GO:0004283 xref: MetaCyc:3.4.21.7-RXN xref: Reactome:9727 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000711 name: acrosin activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [EC:3.4.21.10] synonym: "acrosin amidase activity" EXACT [EC:3.4.21.10] synonym: "acrosomal protease activity" EXACT [EC:3.4.21.10] synonym: "acrosomal proteinase activity" EXACT [EC:3.4.21.10] synonym: "acrozonase activity" EXACT [EC:3.4.21.10] synonym: "alpha-acrosin" RELATED [EC:3.4.21.10] synonym: "beta-acrosin" RELATED [EC:3.4.21.10] synonym: "psi-acrosin" RELATED [EC:3.4.21.10] xref: EC:3.4.21.10 xref: GO:0004284 xref: MetaCyc:3.4.21.10-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000712 name: proprotein convertase 1 activity namespace: molecular_function def: "Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93] synonym: "NEC 1 activity" NARROW [EC:3.4.21.93] synonym: "neuroendocrine convertase 1 activity" NARROW [EC:3.4.21.93] synonym: "PC1 activity" NARROW [EC:3.4.21.93] synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93] synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93] xref: EC:3.4.21.93 xref: GO:0004285 xref: MetaCyc:3.4.21.93-RXN is_a: CCO:F0003378 ! proprotein convertase activity [Term] id: CCO:F0000713 name: proprotein convertase 2 activity namespace: molecular_function def: "Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94] synonym: "NEC 2 activity" NARROW [EC:3.4.21.94] synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94] synonym: "PC2 activity" NARROW [EC:3.4.21.94] synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94] xref: EC:3.4.21.94 xref: GO:0004286 xref: MetaCyc:3.4.21.94-RXN is_a: CCO:F0003378 ! proprotein convertase activity [Term] id: CCO:F0000714 name: prolyl oligopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [EC:3.4.21.26] subset: gosubset_prok synonym: "endoprolylpeptidase activity" EXACT [EC:3.4.21.26] synonym: "post-proline cleaving enzyme activity" EXACT [EC:3.4.21.26] synonym: "post-proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26] xref: EC:3.4.21.26 xref: GO:0004287 xref: MetaCyc:3.4.21.26-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000715 name: subtilase activity namespace: molecular_function subset: gosubset_prok xref: EC:3.4.21.- xref: GO:0004289 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000716 name: kexin activity namespace: molecular_function def: "Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61] synonym: "andrenorphin-Gly-generating enzyme" RELATED [EC:3.4.21.61] synonym: "endoproteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "gene KEX2 dibasic proteinase" NARROW [EC:3.4.21.61] synonym: "Kex 2p proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 endopeptidase" NARROW [EC:3.4.21.61] synonym: "Kex2 endoprotease" NARROW [EC:3.4.21.61] synonym: "Kex2 endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 protease" NARROW [EC:3.4.21.61] synonym: "Kex2 proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like precursor protein processing endoprotease" NARROW [EC:3.4.21.61] synonym: "paired-basic endopeptidase activity" EXACT [EC:3.4.21.61] synonym: "prohormone-processing endoprotease activity" RELATED [EC:3.4.21.61] synonym: "prohormone-processing KEX2 proteinase" NARROW [EC:3.4.21.61] synonym: "prohormone-processing proteinase activity" EXACT [EC:3.4.21.61] synonym: "protease KEX2" RELATED [EC:3.4.21.61] synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61] synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61] synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61] xref: EC:3.4.21.61 xref: GO:0004290 xref: MetaCyc:3.4.21.61-RXN is_a: CCO:F0000715 ! subtilase activity [Term] id: CCO:F0000717 name: subtilisin activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62] subset: gosubset_prok synonym: "alcalase 0.6L" RELATED [EC:3.4.21.62] synonym: "alcalase 2.5L" RELATED [EC:3.4.21.62] synonym: "alcalase activity" EXACT [EC:3.4.21.62] synonym: "ALK-enzyme" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase A" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase B" RELATED [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase activity" EXACT [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase bioprase activity" EXACT [EC:3.4.21.62] synonym: "bioprase AL 15" RELATED [EC:3.4.21.62] synonym: "bioprase APL 30" RELATED [EC:3.4.21.62] synonym: "colistinase activity" EXACT [EC:3.4.21.62] synonym: "esperase activity" EXACT [EC:3.4.21.62] synonym: "genenase I" RELATED [EC:3.4.21.62] synonym: "kazusase activity" EXACT [EC:3.4.21.62] synonym: "maxatase activity" EXACT [EC:3.4.21.62] synonym: "opticlean" RELATED [EC:3.4.21.62] synonym: "orientase 10B" RELATED [EC:3.4.21.62] synonym: "protease S" RELATED [EC:3.4.21.62] synonym: "protease VIII" RELATED [EC:3.4.21.62] synonym: "protease XXVII" RELATED [EC:3.4.21.62] synonym: "protin A 3L" RELATED [EC:3.4.21.62] synonym: "savinase 16.0L" RELATED [EC:3.4.21.62] synonym: "savinase 32.0 L EX" RELATED [EC:3.4.21.62] synonym: "savinase 4.0T" RELATED [EC:3.4.21.62] synonym: "savinase 8.0L" RELATED [EC:3.4.21.62] synonym: "savinase activity" EXACT [EC:3.4.21.62] synonym: "SP 266" RELATED [EC:3.4.21.62] synonym: "subtilisin BL" RELATED [EC:3.4.21.62] synonym: "subtilisin DY" RELATED [EC:3.4.21.62] synonym: "subtilisin E" RELATED [EC:3.4.21.62] synonym: "subtilisin GX" RELATED [EC:3.4.21.62] synonym: "subtilisin J" RELATED [EC:3.4.21.62] synonym: "subtilisin S41" RELATED [EC:3.4.21.62] synonym: "subtilisin sendai" RELATED [EC:3.4.21.62] synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62] synonym: "superase activity" EXACT [EC:3.4.21.62] synonym: "thermoase" BROAD [EC:3.4.21.62] synonym: "thermoase PC 10" RELATED [EC:3.4.21.62] xref: EC:3.4.21.62 xref: GO:0004291 xref: MetaCyc:3.4.21.62-RXN is_a: CCO:F0000715 ! subtilase activity [Term] id: CCO:F0000718 name: tissue kallikrein activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35] synonym: "bradykininogenase" BROAD [EC:3.4.21.35] synonym: "callicrein" RELATED [EC:3.4.21.35] synonym: "depot-padutin" RELATED [EC:3.4.21.35] synonym: "dilminal D" RELATED [EC:3.4.21.35] synonym: "glandular kallikrein activity" RELATED [EC:3.4.21.35] synonym: "glumorin" RELATED [EC:3.4.21.35] synonym: "kallidinogenase" BROAD [EC:3.4.21.35] synonym: "kallikrein" RELATED [EC:3.4.21.35] synonym: "kidney kallikrein" RELATED [EC:3.4.21.35] synonym: "kininogenase" BROAD [EC:3.4.21.35] synonym: "kininogenin activity" RELATED [EC:3.4.21.35] synonym: "onokrein P" RELATED [EC:3.4.21.35] synonym: "padreatin" RELATED [EC:3.4.21.35] synonym: "padutin" RELATED [EC:3.4.21.35] synonym: "pancreatic kallikrein" RELATED [EC:3.4.21.35] synonym: "salivary kallikrein" RELATED [EC:3.4.21.35] synonym: "submandibular kallikrein" RELATED [EC:3.4.21.35] synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35] synonym: "urinary kallikrein" RELATED [EC:3.4.21.35] synonym: "urokallikrein" RELATED [EC:3.4.21.35] xref: EC:3.4.21.35 xref: GO:0004279 xref: GO:0004293 xref: MetaCyc:3.4.21.35-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000719 name: tripeptidyl-peptidase II activity namespace: molecular_function def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10] synonym: "TPP" RELATED [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10] xref: EC:3.4.14.10 xref: GO:0004294 xref: MetaCyc:3.4.14.10-RXN is_a: CCO:F0001790 ! tripeptidyl-peptidase activity [Term] id: CCO:F0000720 name: trypsin activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [EC:3.4.21.4] subset: gosubset_prok synonym: "alpha-trypsin activity" NARROW [EC:3.4.21.4] synonym: "beta-trypsin activity" NARROW [EC:3.4.21.4] synonym: "cocoonase activity" EXACT [EC:3.4.21.4] synonym: "parenzyme" RELATED [EC:3.4.21.4] synonym: "parenzymol" RELATED [EC:3.4.21.4] synonym: "pseudotrypsin" RELATED [EC:3.4.21.4] synonym: "sperm receptor hydrolase activity" EXACT [EC:3.4.21.4] synonym: "tripcellim" RELATED [EC:3.4.21.4] synonym: "tryptar" RELATED [EC:3.4.21.4] synonym: "trypure" RELATED [EC:3.4.21.4] xref: EC:3.4.21.4 xref: GO:0004295 xref: MetaCyc:3.4.21.4-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0000721 name: threonine endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles." [EC:3.4.25.1, GOC:mah] subset: gosubset_prok synonym: "26S protease" NARROW [EC:3.4.25] synonym: "alkaline protease" RELATED [EC:3.4.25] synonym: "ingensin" RELATED [EC:3.4.25] synonym: "large multicatalytic protease" NARROW [EC:3.4.25] synonym: "lens neutral proteinase" NARROW [EC:3.4.25] synonym: "MCP" RELATED [EC:3.4.25] synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25] synonym: "multicatalytic proteinase" NARROW [EC:3.4.25] synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25] synonym: "prosome" RELATED [EC:3.4.25] synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25] synonym: "tricorn protease" NARROW [EC:3.4.25] synonym: "tricorn proteinase" NARROW [EC:3.4.25] xref: EC:3.4.25 xref: GO:0004298 is_a: CCO:F0000644 ! endopeptidase activity [Term] id: CCO:F0000722 name: enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O." [EC:4.2.1.17] subset: gosubset_prok synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.17] synonym: "2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "2-octenoyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "acyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacid dehydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacyl-CoA dehydrase activity" EXACT [EC:4.2.1.17] synonym: "crotonyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "D-3-hydroxyacyl-CoA dehydratase" BROAD [EC:4.2.1.17] synonym: "ECH" RELATED [EC:4.2.1.17] synonym: "enol-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (L)" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "hydratase, enoyl coenzyme A" EXACT [EC:4.2.1.17] synonym: "short chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "short-chain enoyl-CoA hydratase activity" EXACT [] synonym: "trans-2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17] xref: EC:4.2.1.17 xref: GO:0004300 xref: GO:0016510 xref: MetaCyc:ENOYL-COA-HYDRAT-RXN xref: Reactome:10287 xref: UM-BBD_enzymeID:e0014 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000723 name: epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10] subset: gosubset_prok synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "cytosolic epoxide hydrolase activity" EXACT [EC:3.3.2.10] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "sEH" RELATED [EC:3.3.2.10] synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10] synonym: "trans-stilbene oxide hydrolase activity" EXACT [EC:3.3.2.10] xref: EC:3.3.2.10 xref: GO:0004301 xref: MetaCyc:3.3.2.10-RXN xref: UM-BBD_enzymeID:e0397 is_a: CCO:F0003373 ! ether hydrolase activity [Term] id: CCO:F0000724 name: estradiol 17-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] synonym: "17-beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62] synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62] synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-HSD" RELATED [EC:1.1.1.62] synonym: "17beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62] synonym: "estradiol 17beta-dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.62] synonym: "estrogen 17-oxidoreductase activity" EXACT [EC:1.1.1.62] xref: EC:1.1.1.62 xref: GO:0004303 xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000725 name: estrone sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4] synonym: "estrogen sulphotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrone sulphotransferase activity" EXACT [] synonym: "oestrogen sulphotransferase activity" EXACT [EC:2.8.2.4] xref: EC:2.8.2.4 xref: GO:0004304 xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN xref: Reactome:10293 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0000726 name: ethanolamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ethanolamine = ADP + O-phosphoethanolamine." [EC:2.7.1.82] synonym: "ATP:ethanolamine O-phosphotransferase activity" EXACT [EC:2.7.1.82] synonym: "ethanolamine kinase (phosphorylating)" EXACT [EC:2.7.1.82] synonym: "ethanolamine phosphokinase activity" EXACT [EC:2.7.1.82] xref: EC:2.7.1.82 xref: GO:0004305 xref: MetaCyc:ETHANOLAMINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000727 name: ethanolamine-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14] synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "ET" RELATED [EC:2.7.7.14] synonym: "ethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT [] synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14] xref: EC:2.7.7.14 xref: GO:0004306 xref: MetaCyc:2.7.7.14-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000728 name: ethanolaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1] synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "CDPethanolamine diglyceride phosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "EPT" RELATED [EC:2.7.8.1] synonym: "phosphorylethanolamine-glyceride transferase activity" EXACT [EC:2.7.8.1] xref: EC:2.7.8.1 xref: GO:0004307 xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN is_a: CCO:F0003607 ! CDP-alcohol phosphatidyltransferase activity [Term] id: CCO:F0000729 name: exo-alpha-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18] subset: gosubset_prok synonym: "acetylneuraminidase activity" EXACT [EC:3.2.1.18] synonym: "acetylneuraminyl hydrolase activity" EXACT [EC:3.2.1.18] synonym: "alpha-neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "N-acylneuraminate glycohydrolase activity" EXACT [EC:3.2.1.18] synonym: "neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "sialidase activity" EXACT [EC:3.2.1.18] xref: EC:3.2.1.18 xref: GO:0004308 xref: MetaCyc:3.2.1.18-RXN is_a: CCO:F0003509 ! alpha-sialidase activity [Term] id: CCO:F0000730 name: exopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11] subset: gosubset_prok synonym: "acid phosphoanhydride phosphohydrolase activity" EXACT [EC:3.6.1.11] synonym: "exopolypase activity" EXACT [EC:3.6.1.11] synonym: "Gra-pase activity" EXACT [EC:3.6.1.11] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11] synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11] xref: EC:3.6.1.11 xref: GO:0004309 xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0000731 name: farnesyl-diphosphate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21] subset: gosubset_prok synonym: "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity" EXACT [EC:2.5.1.21] synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.21] synonym: "presqualene synthase activity" EXACT [EC:2.5.1.21] synonym: "presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21] synonym: "squalene synthase activity" EXACT [EC:2.5.1.21] synonym: "squalene synthetase activity" EXACT [EC:2.5.1.21] xref: EC:2.5.1.21 xref: GO:0004310 xref: MetaCyc:2.5.1.21-RXN xref: Reactome:10334 is_a: CCO:F0000732 ! farnesyltranstransferase activity [Term] id: CCO:F0000732 name: farnesyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29] subset: gosubset_prok synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29] synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [EC:2.5.1.29] xref: EC:2.5.1.29 xref: GO:0004311 xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN xref: Reactome:10335 is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0000733 name: fatty-acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] subset: gosubset_prok synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85] xref: EC:2.3.1.85 xref: GO:0004312 xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0000736 name: 3-oxoacyl-[acyl-carrier-protein] synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41] subset: gosubset_prok synonym: "3-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT [] synonym: "3-oxoacyl-ACP synthase activity" EXACT [] synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl:ACP synthase I" RELATED [EC:2.3.1.41] synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthase I activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" RELATED [EC:2.3.1.41] synonym: "beta-ketoacylsynthase activity" EXACT [EC:2.3.1.41] synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "FabB" RELATED [EC:2.3.1.41] synonym: "FabF1" RELATED [EC:2.3.1.41] synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "KAS I activity" NARROW [EC:2.3.1.41] synonym: "KASI" RELATED [EC:2.3.1.41] synonym: "ketoacyl-ACP synthase activity" EXACT [] xref: EC:2.3.1.41 xref: GO:0004315 xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN xref: Reactome:76136 is_a: CCO:F0000733 ! fatty-acid synthase activity [Term] id: CCO:F0000737 name: 3-oxoacyl-[acyl-carrier-protein] reductase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] subset: gosubset_prok synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.100] synonym: "3-ketoacyl acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT [] synonym: "3-oxoacyl-ACP reductase activity" EXACT [] synonym: "3-oxoacyl-ACPreductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl thioester reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-ACP reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT [EC:1.1.1.100] xref: EC:1.1.1.100 xref: GO:0004316 xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN xref: Reactome:76148 is_a: CCO:F0000733 ! fatty-acid synthase activity is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000738 name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.61] synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmitoyl thioester dehydratase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmityl-ACP dehydrase activity" EXACT [EC:4.2.1.61] synonym: "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.61] synonym: "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] xref: EC:4.2.1.61 xref: GO:0004317 xref: MetaCyc:4.2.1.61-RXN is_a: CCO:F0000733 ! fatty-acid synthase activity is_a: CCO:F0004104 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: CCO:F0000739 name: enoyl-[acyl-carrier-protein] reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9] subset: gosubset_prok synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" EXACT [EC:1.3.1.9] synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-ACP reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.3.1.9] synonym: "NADH-enoyl acyl carrier protein reductase activity" EXACT [EC:1.3.1.9] synonym: "NADH-specific enoyl-ACP reductase activity" EXACT [EC:1.3.1.9] xref: EC:1.3.1.9 xref: GO:0004318 xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN is_a: CCO:F0000733 ! fatty-acid synthase activity is_a: CCO:F0003232 ! enoyl-[acyl-carrier-protein] reductase activity [Term] id: CCO:F0000740 name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10] subset: gosubset_prok synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl acyl-carrier-protein reductase activity" EXACT [EC:1.3.1.10] synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" EXACT [EC:1.3.1.10] synonym: "NADPH 2-enoyl Co A reductase activity" EXACT [EC:1.3.1.10] synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.10] xref: EC:1.3.1.10 xref: GO:0004319 xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN xref: Reactome:76151 is_a: CCO:F0000733 ! fatty-acid synthase activity is_a: CCO:F0003232 ! enoyl-[acyl-carrier-protein] reductase activity [Term] id: CCO:F0000741 name: oleoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14] subset: gosubset_prok synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "oleoyl-ACP hydrolase activity" EXACT [] synonym: "oleoyl-ACP thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl carrier protein thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14] xref: EC:3.1.2.14 xref: GO:0004320 xref: MetaCyc:3.1.2.14-RXN xref: MetaCyc:PWY-5142 xref: Reactome:76154 is_a: CCO:F0003110 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: CCO:F0000742 name: fatty-acyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" EXACT [EC:2.3.1.86] synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86] xref: EC:2.3.1.86 xref: GO:0004321 xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN is_a: CCO:F0003131 ! C-acyltransferase activity [Term] id: CCO:F0000743 name: ferroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] subset: gosubset_prok synonym: "caeruloplasmin" RELATED [EC:1.16.3.1] synonym: "ceruloplasmin activity" NARROW [EC:1.16.3.1] synonym: "Fe(II):oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferro:O2 oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferroxidase I" RELATED [EC:1.16.3.1] synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "iron(II): oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "multicopper ferroxidase iron transport mediator activity" NARROW [] xref: EC:1.16.3.1 xref: GO:0004322 xref: MetaCyc:RXN0-1483 is_a: CCO:F0003306 ! oxidoreductase activity, oxidizing metal ions, oxygen as acceptor [Term] id: CCO:F0000744 name: ferredoxin-NADP+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [EC:1.18.1.2, GOC:kd] comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'. subset: gosubset_prok synonym: "ferredoxin-NADP oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-NADP reductase activity" EXACT [] synonym: "ferredoxin-NADP-oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-TPN reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADP:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADPH:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" EXACT [EC:1.18.1.2] synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.2 xref: GO:0004324 is_a: CCO:F0002273 ! ferredoxin reductase activity [Term] id: CCO:F0000745 name: ferrochelatase activity namespace: molecular_function def: "Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [EC:4.99.1.1] subset: gosubset_prok synonym: "ferro-protoporphyrin chelatase activity" EXACT [EC:4.99.1.1] synonym: "heme synthase activity" EXACT [EC:4.99.1.1] synonym: "heme synthetase activity" EXACT [EC:4.99.1.1] synonym: "iron chelatase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferrolyase activity" EXACT [EC:4.99.1.1] xref: EC:4.99.1.1 xref: GO:0004325 xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN xref: Reactome:10394 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0000746 name: tetrahydrofolylpolyglutamate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17] subset: gosubset_prok synonym: "folate polyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly(gamma-glutamate) synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamate synthase activity" EXACT [] synonym: "folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamyl synthetase activity" EXACT [EC:6.3.2.17] synonym: "formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "FPGS activity" EXACT [EC:6.3.2.17] synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate synthase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] xref: EC:6.3.2.17 xref: GO:0004326 xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0000747 name: formaldehyde dehydrogenase (glutathione) activity namespace: molecular_function def: "Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1] subset: gosubset_prok xref: GO:0004327 xref: UM-BBD_enzymeID:e0028 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000748 name: formamidase activity namespace: molecular_function def: "Catalysis of the reaction: formamide + H2O = formate + NH3." [EC:3.5.1.49] subset: gosubset_prok synonym: "formamide amidohydrolase activity" EXACT [EC:3.5.1.49] xref: EC:3.5.1.49 xref: GO:0004328 xref: MetaCyc:FORMAMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000749 name: formate-tetrahydrofolate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3] subset: gosubset_prok synonym: "10-formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "formate:tetrahydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.3] synonym: "formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolate formylase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolic formylase activity" EXACT [EC:6.3.4.3] xref: EC:6.3.4.3 xref: GO:0004329 xref: MetaCyc:FORMATETHFLIG-RXN is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0000750 name: fructose-2,6-bisphosphate 2-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.46] subset: gosubset_prok synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "fructose-2,6-bisphosphatase activity" EXACT [EC:3.1.3.46] xref: EC:3.1.3.46 xref: GO:0004330 xref: GO:0004331 xref: MetaCyc:3.1.3.46-RXN xref: Reactome:10434 is_a: CCO:F0004126 ! carbohydrate phosphatase activity [Term] id: CCO:F0000751 name: fructose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.13] subset: gosubset_prok synonym: "1,6-diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "aldolase activity" BROAD [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-monophosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "ketose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "phosphofructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "SMALDO" RELATED [EC:4.1.2.13] synonym: "zymohexase activity" EXACT [EC:4.1.2.13] xref: EC:4.1.2.13 xref: GO:0004332 xref: MetaCyc:F16ALDOLASE-RXN xref: Reactome:10435 is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0000752 name: fumarate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate = fumarate + H2O." [EC:4.2.1.2] subset: gosubset_prok synonym: "(S)-malate hydro-lyase (fumarate-forming)" EXACT [EC:4.2.1.2] synonym: "(S)-malate hydro-lyase activity" EXACT [EC:4.2.1.2] synonym: "fumarase activity" EXACT [EC:4.2.1.2] synonym: "L-malate hydro-lyase activity" EXACT [EC:4.2.1.2] xref: EC:4.2.1.2 xref: GO:0004333 xref: MetaCyc:FUMHYDR-RXN xref: Reactome:10436 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000753 name: fumarylacetoacetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate." [EC:3.7.1.2] subset: gosubset_prok synonym: "4-fumarylacetoacetate fumarylhydrolase activity" EXACT [EC:3.7.1.2] synonym: "beta-diketonase activity" EXACT [EC:3.7.1.2] synonym: "fumarylacetoacetate hydrolase activity" EXACT [EC:3.7.1.2] xref: EC:3.7.1.2 xref: GO:0004334 xref: MetaCyc:FUMARYLACETOACETASE-RXN xref: Reactome:10438 xref: UM-BBD_enzymeID:e0083 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0000754 name: galactokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate." [EC:2.7.1.6] subset: gosubset_prok synonym: "ATP:D-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "ATP:D-galactose-1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "galactokinase (phosphorylating)" EXACT [EC:2.7.1.6] xref: EC:2.7.1.6 xref: GO:0004335 xref: MetaCyc:GALACTOKIN-RXN xref: Reactome:10440 is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0000755 name: galactosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46] synonym: "beta-galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "beta-galactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "ceramide galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside-beta-D-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside.beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46] synonym: "galactosylceramide beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylceramide.beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylcerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galcerase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46] xref: EC:3.2.1.46 xref: GO:0004336 xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: CCO:F0003524 ! ceramidase activity [Term] id: CCO:F0000756 name: geranyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate." [EC:2.5.1.10] comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. subset: gosubset_prok synonym: "farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "farnesyl pyrophosphate synthetase activity" EXACT [] synonym: "farnesyl-diphosphate synthase activity" EXACT [] synonym: "farnesylpyrophosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "FPP synthetase activity" EXACT [EC:2.5.1.10] synonym: "geranyl transferase I" RELATED [EC:2.5.1.10] synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" EXACT [EC:2.5.1.10] synonym: "geranyltransferase activity" EXACT [EC:2.5.1.10] xref: EC:2.5.1.10 xref: GO:0004337 xref: MetaCyc:FPPSYN-RXN is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0000757 name: glucan 1,3-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58] synonym: "1,3-beta-glucan glucohydrolase activity" EXACT [EC:3.2.1.58] synonym: "beta-1,3-glucan exo-hydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo (1->3)-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucosidase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-glucanohydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-glucanase activity" EXACT [EC:3.2.1.58] xref: EC:3.2.1.58 xref: GO:0004338 xref: MetaCyc:3.2.1.58-RXN is_a: CCO:F0001889 ! beta-glucosidase activity [Term] id: CCO:F0000758 name: glucan 1,4-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3] comment: Note that this term is not a child of 'alpha-glucosides activity ; GO:0004558', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0004558 alpha-D-glucose is released. subset: gosubset_prok synonym: "1,4-alpha-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "amyloglucosidase activity" EXACT [EC:3.2.1.3] synonym: "exo-1,4-alpha-glucosidase activity" EXACT [EC:3.2.1.3] synonym: "gamma-1,4-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "gamma-amylase activity" EXACT [EC:3.2.1.3] synonym: "glucoamylase activity" EXACT [] synonym: "glucose amylase activity" EXACT [EC:3.2.1.3] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3] xref: EC:3.2.1.3 xref: GO:0004339 xref: MetaCyc:3.2.1.3-RXN is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0000759 name: glucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate." [EC:2.7.1.2] subset: gosubset_prok synonym: "ATP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.2] synonym: "glucokinase (phosphorylating)" EXACT [EC:2.7.1.2] synonym: "glucose kinase activity" EXACT [EC:2.7.1.2] xref: EC:2.7.1.2 xref: GO:0004340 xref: MetaCyc:GLUCOKIN-RXN xref: Reactome:10457 is_a: CCO:F0000807 ! hexokinase activity [Term] id: CCO:F0000760 name: gluconolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17] subset: gosubset_prok synonym: "aldonolactonase activity" EXACT [EC:3.1.1.17] synonym: "D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.17] synonym: "glucono-delta-lactonase activity" EXACT [EC:3.1.1.17] synonym: "gulonolactonase activity" EXACT [EC:3.1.1.17] synonym: "lactonase activity" BROAD [EC:3.1.1.17] xref: EC:3.1.1.17 xref: GO:0004341 xref: MetaCyc:GLUCONOLACT-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0000761 name: glucosamine-6-phosphate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3." [EC:3.5.99.6] comment: Note that this function was formerly EC:5.3.1.10. subset: gosubset_prok synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" EXACT [EC:3.5.99.6] synonym: "aminodeoxyglucosephosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "GlcN6P deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine phosphate deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine-6-phosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6] synonym: "phosphoglucosamine isomerase activity" EXACT [EC:3.5.99.6] synonym: "phosphoglucosaminisomerase activity" EXACT [EC:3.5.99.6] xref: EC:3.5.99.6 xref: GO:0004342 xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0000762 name: glucosamine 6-phosphate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate." [EC:2.3.1.4] subset: gosubset_prok synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "aminodeoxyglucosephosphate acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "D-glucosamine-6-P N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine 6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT [] synonym: "N-acetylglucosamine-6-phosphate synthase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine N-acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine transacetylase activity" EXACT [EC:2.3.1.4] xref: EC:2.3.1.4 xref: GO:0004343 xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0000763 name: glucose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] synonym: "D-glucose:(acceptor) 1-oxidoreductase" EXACT [EC:1.1.99.10] synonym: "D-glucose:acceptor 1-oxidoreductase" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (acceptor) activity" EXACT [] synonym: "glucose dehydrogenase (Aspergillus) activity" NARROW [EC:1.1.99.10] synonym: "glucose dehydrogenase (decarboxylating)" EXACT [EC:1.1.99.10] xref: EC:1.1.-.- xref: EC:1.1.99.10 xref: GO:0004344 xref: GO:0008708 xref: MetaCyc:GLUCOSE-DEHYDROGENASE-(ACCEPTOR)-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0000764 name: glucose-6-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] subset: gosubset_prok synonym: "6-phosphoglucose dehydrogenas" RELATED [] synonym: "6-phosphoglucose dehydrogenase activity" EXACT [] synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.49] synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49] synonym: "G6PD activity" EXACT [EC:1.1.1.49] synonym: "G6PDH" EXACT [] synonym: "GDH" RELATED [] synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT [] synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT [] synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT [] synonym: "Zwischenferment" RELATED [] synonym: "zwischenferment" RELATED [EC:1.1.1.49] xref: EC:1.1.1.49 xref: GO:0004345 xref: MetaCyc:GLU6PDEHYDROG-RXN xref: Reactome:10468 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000765 name: glucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.9] subset: gosubset_prok synonym: "D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.9] synonym: "glucose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.9] xref: EC:3.1.3.9 xref: GO:0004346 xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN xref: Reactome:10470 is_a: CCO:F0004126 ! carbohydrate phosphatase activity [Term] id: CCO:F0000766 name: glucose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9] subset: gosubset_prok synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.9] synonym: "D-glucose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.9] synonym: "glucose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "hexose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9] synonym: "phosphoglucoisomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphoglucose isomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9] xref: EC:5.3.1.9 xref: GO:0004347 xref: MetaCyc:PGLUCISOM-RXN xref: Reactome:10472 is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0000767 name: glucosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45] subset: gosubset_prok synonym: "acid beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-D-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucosylceramidase activity" EXACT [EC:3.2.1.45] synonym: "ceramide glucosidase activity" EXACT [EC:3.2.1.45] synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [EC:3.2.1.45] synonym: "GlcCer-beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosphingosine glucosylhydrolase activity" EXACT [EC:3.2.1.45] synonym: "glucosylcerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-D-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "psychosine hydrolase activity" EXACT [EC:3.2.1.45] xref: EC:3.2.1.45 xref: GO:0004348 xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: CCO:F0003524 ! ceramidase activity [Term] id: CCO:F0000768 name: glutamate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate." [EC:2.7.2.11] subset: gosubset_prok synonym: "ATP-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:gamma-L-glutamate phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamate kinase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamyl kinase activity" EXACT [EC:2.7.2.11] synonym: "glutamate kinase activity" EXACT [EC:2.7.2.11] xref: EC:2.7.2.11 xref: GO:0004349 xref: MetaCyc:GLUTKIN-RXN is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor is_a: CCO:F0004125 ! amino acid kinase activity [Term] id: CCO:F0000769 name: glutamate-5-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+." [EC:1.2.1.41] subset: gosubset_prok synonym: "beta-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamyl phosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-phosphate reductase activity" EXACT [] synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamylphosphate reductase activity" EXACT [] synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.41] xref: EC:1.2.1.41 xref: GO:0001513 xref: GO:0004350 xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000770 name: glutamate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15] subset: gosubset_prok synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15] synonym: "cysteic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "gamma-glutamate decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-aspartate-alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15] xref: EC:4.1.1.15 xref: GO:0004351 xref: MetaCyc:GLUTDECARBOX-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000771 name: glutamate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2] subset: gosubset_prok synonym: "glutamate dehydrogenase (NAD)" EXACT [EC:1.4.1.2] synonym: "glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2] synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD:glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "NADH-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] xref: EC:1.4.1.2 xref: GO:0004352 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000772 name: glutamate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. subset: gosubset_prok synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3] synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.3] xref: EC:1.4.1.3 xref: GO:0004353 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-(NAD(P)+)-RXN xref: MetaCyc:GLUTAMATE-SYN2-PWY xref: Reactome:10485 is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000773 name: glutamate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4] subset: gosubset_prok synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.4.1.4] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4] synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.4] synonym: "L-glutamic acid dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)-glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] xref: EC:1.4.1.4 xref: GO:0004354 xref: MetaCyc:GLUTDEHYD-RXN xref: MetaCyc:GLUTSYNIII-PWY is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000774 name: glutamate synthase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. subset: gosubset_prok synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" EXACT [EC:1.4.1.13] synonym: "glutamate synthetase (NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine-ketoglutaric aminotransferase activity" EXACT [EC:1.4.1.13] synonym: "GOGAT activity" EXACT [EC:1.4.1.13] synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.13] synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" EXACT [EC:1.4.1.13] synonym: "NADPH-dependent glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-linked glutamate synthase" EXACT [EC:1.4.1.13] xref: EC:1.4.1.13 xref: GO:0004355 xref: MetaCyc:GLUGLNSYN-PWY xref: MetaCyc:GLUTAMATESYN-RXN xref: MetaCyc:GLUTSYN-PWY is_a: CCO:F0006093 ! glutamate synthase activity, NADH or NADPH as acceptor [Term] id: CCO:F0000775 name: glutamate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine." [EC:6.3.1.2] subset: gosubset_prok synonym: "glutamine synthetase activity" EXACT [] synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2] synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2] synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2] xref: EC:6.3.1.2 xref: GO:0004356 xref: MetaCyc:GLUTAMINESYN-RXN xref: Reactome:10495 is_a: CCO:F0003071 ! ammonia ligase activity [Term] id: CCO:F0000776 name: glutamate-cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine." [EC:6.3.2.2] subset: gosubset_prok synonym: "gamma-glutamyl-L-cysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteinyl synthetase activity" EXACT [EC:6.3.2.2] synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.2] xref: EC:6.3.2.2 xref: GO:0004357 xref: MetaCyc:GLUTCYSLIG-RXN xref: Reactome:10497 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0000777 name: glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate." [EC:2.3.1.35] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35] synonym: "acetylornithine glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine transacetylase activity" EXACT [EC:2.3.1.35] xref: EC:2.3.1.35 xref: GO:0004358 xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0000778 name: glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2] subset: gosubset_prok synonym: "glutaminase I" RELATED [EC:3.5.1.2] synonym: "glutamine aminohydrolase activity" EXACT [EC:3.5.1.2] synonym: "L-glutaminase activity" EXACT [EC:3.5.1.2] synonym: "L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.2] xref: EC:3.5.1.2 xref: GO:0004359 xref: MetaCyc:GLUTAMIN-RXN xref: Reactome:10219 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000779 name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate." [EC:2.6.1.16] subset: gosubset_prok synonym: "D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "GlcN6P synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine 6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" EXACT [EC:2.6.1.16] synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT [] synonym: "glucosamine-6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16] synonym: "hexosephosphate aminotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" EXACT [EC:2.6.1.16] xref: EC:2.6.1.16 xref: GO:0004360 xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0000780 name: glutaryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.99.7] subset: gosubset_prok synonym: "glutaryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.7] synonym: "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] synonym: "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] xref: EC:1.3.99.7 xref: GO:0004361 xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN xref: Reactome:10507 xref: UM-BBD_enzymeID:e0123 is_a: CCO:F0000480 ! acyl-CoA dehydrogenase activity [Term] id: CCO:F0000781 name: glutathione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this function was formerly EC:1.6.4.2. subset: gosubset_prok synonym: "glutathione reductase (NADPH) activity" EXACT [] synonym: "glutathione reductase activity" EXACT [] synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7] synonym: "glutathione-disulphide reductase activity" EXACT [] synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "GSH reductase activity" EXACT [EC:1.8.1.7] synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "oxidized glutathione reduction" RELATED [] xref: EC:1.8.1.7 xref: GO:0004362 xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN xref: Reactome:10508 is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0002535 ! glutathione disulfide oxidoreductase activity is_a: CCO:F0003069 ! antioxidant activity is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000782 name: glutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione." [EC:6.3.2.3] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" EXACT [EC:6.3.2.3] synonym: "glutathione synthetase activity" EXACT [EC:6.3.2.3] synonym: "GSH synthetase activity" EXACT [EC:6.3.2.3] xref: EC:6.3.2.3 xref: GO:0004363 xref: MetaCyc:GLUTATHIONE-SYN-RXN xref: Reactome:10524 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0000783 name: glutathione transferase activity namespace: molecular_function def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] subset: gosubset_prok synonym: "glutathione conjugation reaction" EXACT [] synonym: "glutathione S-alkyl transferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-alkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aralkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aryltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-transferase activity" EXACT [EC:2.5.1.18] synonym: "RX:glutathione R-transferase activity" EXACT [EC:2.5.1.18] synonym: "S-(hydroxyalkyl)glutathione lyase activity" EXACT [EC:2.5.1.18] xref: EC:2.5.1.18 xref: GO:0004364 xref: MetaCyc:GSHTRAN-RXN xref: Reactome:10527 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0000784 name: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12] subset: gosubset_prok synonym: "3-phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.12] synonym: "dehydrogenase, glyceraldehyde phosphate" EXACT [EC:1.2.1.12] synonym: "GAPDH activity" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde-3-P-dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12] xref: EC:1.2.1.12 xref: GO:0004365 xref: MetaCyc:GAPOXNPHOSPHN-RXN xref: Reactome:10530 is_a: CCO:F0002279 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: CCO:F0000785 name: glycerol-3-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15] subset: gosubset_prok synonym: "3-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "alpha-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] xref: EC:2.3.1.15 xref: GO:0004366 xref: MetaCyc:RXN-1381 xref: Reactome:10531 is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0000786 name: glycerol-3-phosphate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8] subset: gosubset_prok synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol 1-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] synonym: "glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "hydroglycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "L-alpha-glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "L-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "L-glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "L-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NADH-dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.8] xref: EC:1.1.1.8 xref: GO:0004367 xref: MetaCyc:1.1.1.8-RXN xref: Reactome:10533 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000787 name: glycerol-3-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor." [EC:1.1.99.5] subset: gosubset_prok synonym: "alpha-glycerophosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "alpha-glycerophosphate dehydrogenase (acceptor)" EXACT [EC:1.1.99.5] synonym: "dehydrogenase, glycerol phosphate (acceptor)" EXACT [EC:1.1.99.5] synonym: "DL-glycerol 3-phosphate oxidase" EXACT [EC:1.1.99.5] synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "FAD-dependent sn-glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "FAD-linked glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "FAD-linked L-glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "flavoprotein-linked L-glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "glycerol 3-phosphate cytochrome c reductase" NARROW [EC:1.1.99.5] synonym: "glycerol phosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "glycerol phosphate dehydrogenase (acceptor)" EXACT [EC:1.1.99.5] synonym: "glycerol phosphate dehydrogenase (FAD)" NARROW [EC:1.1.99.5] synonym: "glycerol-3-phosphate dehydrogenase (flavin-linked)" NARROW [EC:1.1.99.5] synonym: "glycerophosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "L-3-glycerophosphate-ubiquinone oxidoreductase" EXACT [EC:1.1.99.5] synonym: "L-glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "NAD-independent glycerol phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "sn-glycerol 3-phosphate oxidase" EXACT [EC:1.1.99.5] synonym: "sn-glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.5] synonym: "sn-glycerol-3-phosphate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.5] xref: EC:1.1.99.5 xref: GO:0004368 xref: MetaCyc:GLYCEROL-3-PHOSPHATE-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0000788 name: glycerol-3-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2." [EC:1.1.3.21] subset: gosubset_prok synonym: "alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol-1-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerol-3-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.21] xref: EC:1.1.3.21 xref: GO:0004369 xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0000789 name: glycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate." [EC:2.7.1.30] subset: gosubset_prok synonym: "ATP:glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "ATP:glycerol-3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "GK" RELATED [EC:2.7.1.30] synonym: "glyceric kinase activity" EXACT [EC:2.7.1.30] synonym: "glycerokinase activity" EXACT [EC:2.7.1.30] synonym: "glycerol kinase (phosphorylating)" EXACT [EC:2.7.1.30] xref: EC:2.7.1.30 xref: GO:0004370 xref: MetaCyc:GLYCEROL-KIN-RXN xref: Reactome:10545 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000790 name: glycerone kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate." [EC:2.7.1.29] subset: gosubset_prok synonym: "acetol kinase (phosphorylating)" EXACT [EC:2.7.1.29] synonym: "acetol kinase activity" EXACT [EC:2.7.1.29] synonym: "ATP:glycerone phosphotransferase activity" EXACT [EC:2.7.1.29] synonym: "dihydroxyacetone kinase activity" EXACT [EC:2.7.1.29] xref: EC:2.7.1.29 xref: GO:0004371 xref: MetaCyc:GLYCERONE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000791 name: glycine hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "allothreonine aldolase activity" EXACT [EC:2.1.2.1] synonym: "L-serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine aldolase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethylase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine transhydroxymethylase activity" EXACT [EC:2.1.2.1] xref: EC:2.1.2.1 xref: GO:0004372 xref: MetaCyc:GLYOHMETRANS-RXN xref: Reactome:1060 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0000792 name: glycogen (starch) synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11] subset: gosubset_prok synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen transglucosylase activity" EXACT [EC:2.4.1.11] synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] xref: EC:2.4.1.11 xref: GO:0004373 xref: MetaCyc:GLYCOGEN-(STARCH)-SYNTHASE-RXN xref: Reactome:10552 is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0000793 name: glycine dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] subset: gosubset_prok synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2] synonym: "glycine decarboxylase activity" EXACT [EC:1.4.4.2] synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2] synonym: "glycine-cleavage complex P-protein activity" EXACT [EC:1.4.4.2] synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" EXACT [EC:1.4.4.2] synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" EXACT [EC:1.4.4.2] synonym: "P-protein" NARROW [EC:1.4.4.2] synonym: "protein P1" NARROW [EC:1.4.4.2] xref: EC:1.4.4.2 xref: GO:0004375 xref: MetaCyc:GCVP-RXN is_a: CCO:F0003242 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor [Term] id: CCO:F0000794 name: glycolipid mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai] synonym: "glycolipid mannosyl transferase activity" EXACT [] xref: EC:2.4.1.- xref: GO:0004376 xref: GO:0004580 xref: Reactome:10559 is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0000795 name: glycolipid 2-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose linkage." [EC:2.4.1.131] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] xref: EC:2.4.1.131 xref: GO:0004377 xref: MetaCyc:2.4.1.131-RXN is_a: CCO:F0000007 ! alpha-1,2-mannosyltransferase activity is_a: CCO:F0000794 ! glycolipid mannosyltransferase activity [Term] id: CCO:F0000796 name: glycolipid 3-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,3-D-mannosyl-D-mannose linkage." [EC:2.4.1.132] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132] synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "mannosyltransferase II activity" EXACT [EC:2.4.1.132] xref: EC:2.4.1.132 xref: GO:0004378 xref: MetaCyc:2.4.1.132-RXN is_a: CCO:F0000794 ! glycolipid mannosyltransferase activity [Term] id: CCO:F0000797 name: glycylpeptide N-tetradecanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97] synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" EXACT [EC:2.3.1.97] synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97] synonym: "N-myristoyltransferase activity" EXACT [] synonym: "peptide N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "peptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] xref: EC:2.3.1.97 xref: GO:0004379 xref: GO:0019106 xref: MetaCyc:2.3.1.97-RXN is_a: CCO:F0003133 ! N-acyltransferase activity is_a: CCO:F0004053 ! myristoyltransferase activity [Term] id: CCO:F0000798 name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40] synonym: "A transferase activity" RELATED [EC:2.4.1.40] synonym: "A-transferase activity" EXACT [EC:2.4.1.40] synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance alpha-acetyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40] synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" EXACT [EC:2.4.1.40] synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40] synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] xref: EC:2.4.1.40 xref: GO:0004380 xref: MetaCyc:2.4.1.40-RXN is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0000799 name: fucosylgalactoside 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37] synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "B transferase activity" RELATED [EC:2.4.1.37] synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT [] synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37] synonym: "histo-blood substance B-dependent galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] xref: EC:2.4.1.37 xref: GO:0004381 xref: MetaCyc:2.4.1.37-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0000800 name: guanosine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286] synonym: "GDP phosphohydrolase activity" EXACT [EC:3.6.1.42] synonym: "GDPase activity" EXACT [EC:3.6.1.42] synonym: "guanosine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "guanosine diphosphatase activity" EXACT [] xref: EC:3.6.1.42 xref: GO:0004382 xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN is_a: CCO:F0003573 ! nucleoside-diphosphatase activity [Term] id: CCO:F0000801 name: guanylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] subset: gosubset_prok synonym: "GTP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.2] synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" EXACT [EC:4.6.1.2] synonym: "guanyl cyclase activity" EXACT [EC:4.6.1.2] synonym: "guanylyl cyclase activity" EXACT [] synonym: "receptor guanylate cyclase activity" NARROW [] xref: EC:4.6.1.2 xref: GO:0004383 xref: MetaCyc:GUANYLCYC-RXN is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003413 ! phosphorus-oxygen lyase activity [Term] id: CCO:F0000802 name: guanylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] subset: gosubset_prok synonym: "5'-GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "ATP:(d)GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "ATP:GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8] synonym: "GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "guanosine monophosphate kinase activity" EXACT [EC:2.7.4.8] synonym: "membrane-associated guanylate kinase" NARROW [] xref: EC:2.7.4.8 xref: GO:0004385 xref: MetaCyc:GUANYL-KIN-RXN is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor is_a: CCO:F0004124 ! nucleotide kinase activity [Term] id: CCO:F0000803 name: helicase activity namespace: molecular_function def: "Catalysis of the unwinding of a DNA or RNA duplex." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that most helicases catalyze processive duplex unwinding. subset: goslim_candida subset: goslim_goa subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: GO:0004386 xref: Reactome:7001 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0000804 name: heme oxygenase (decyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3] synonym: "haem oxidase activity" EXACT [EC:1.14.99.3] synonym: "haem oxygenase (decyclizing) activity" EXACT [] synonym: "haem oxygenase activity" EXACT [EC:1.14.99.3] synonym: "heme oxidase activity" EXACT [EC:1.14.99.3] synonym: "heme oxygenase activity" EXACT [EC:1.14.99.3] synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" EXACT [EC:1.14.99.3] synonym: "ORP33 proteins" RELATED [EC:1.14.99.3] xref: EC:1.14.99.3 xref: GO:0004392 xref: MetaCyc:HEME-OXYGENASE-(DECYCLIZING)-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0000805 name: heparan sulfate 2-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262] synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT [] synonym: "heparin sulfate 2-sulfotransferase activity" RELATED [] synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED [] xref: EC:2.8.2.- xref: GO:0004394 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0000806 name: hexaprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] synonym: "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB-Mt activity" EXACT [EC:2.1.1.114] synonym: "dihydroxyhexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity" EXACT [EC:2.1.1.114] xref: EC:2.1.1.114 xref: GO:0004395 xref: MetaCyc:2.1.1.114-RXN is_a: CCO:F0002494 ! polyprenyldihydroxybenzoate methyltransferase activity [Term] id: CCO:F0000807 name: hexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1] subset: gosubset_prok synonym: "ATP-dependent hexokinase activity" EXACT [EC:2.7.1.1] synonym: "ATP:D-hexose 6-phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "glucose ATP phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "hexokinase (phosphorylating)" EXACT [EC:2.7.1.1] synonym: "hexokinase D" RELATED [EC:2.7.1.1] synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV" RELATED [EC:2.7.1.1] synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV glucokinase activity" EXACT [EC:2.7.1.1] xref: EC:2.7.1.1 xref: GO:0004396 xref: MetaCyc:HEXOKINASE-RXN xref: Reactome:10602 is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0000808 name: histidine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3] subset: gosubset_prok synonym: "histidase activity" RELATED [GOC:hjd] synonym: "histidinase activity" RELATED [GOC:hjd] synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd] synonym: "L-histidine ammonia-lyase (urocanate-forming)" EXACT [EC:4.3.1.3] synonym: "L-histidine ammonia-lyase activity" EXACT [EC:4.3.1.3] xref: EC:4.3.1.3 xref: GO:0004397 xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN xref: Reactome:10604 is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0000809 name: histidine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22] subset: gosubset_prok synonym: "L-histidine carboxy-lyase (histamine-forming)" EXACT [EC:4.1.1.22] synonym: "L-histidine carboxy-lyase activity" EXACT [EC:4.1.1.22] synonym: "L-histidine decarboxylase activity" EXACT [EC:4.1.1.22] xref: EC:4.1.1.22 xref: GO:0004398 xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000810 name: histidinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [EC:1.1.1.23] subset: gosubset_prok xref: EC:1.1.1.23 xref: GO:0004399 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000811 name: histidinol-phosphate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9] subset: gosubset_prok synonym: "glutamic-imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidine:imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "histidinol-phosphate aminotransferase activity" EXACT [] synonym: "IAP transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazole acetol-phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.9] xref: EC:2.6.1.9 xref: GO:0004400 xref: MetaCyc:HISTAMINOTRANS-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0000812 name: histidinol-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol-phosphate + H2O = L-histidinol + phosphate." [EC:3.1.3.15] subset: gosubset_prok synonym: "histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "HPpase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.15] xref: EC:3.1.3.15 xref: GO:0004401 xref: MetaCyc:HISTIDPHOS-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0000813 name: histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant. synonym: "acetyl-CoA:histone acetyltransferase activity" EXACT [EC:2.3.1.48] synonym: "histone acetokinase activity" EXACT [EC:2.3.1.48] synonym: "histone acetylase activity" EXACT [] synonym: "histone lysine acetyltransferase activity" EXACT [] synonym: "histone transacetylase activity" EXACT [EC:2.3.1.48] synonym: "nucleosome-histone acetyltransferase activity" EXACT [EC:2.3.1.48] xref: EC:2.3.1.48 xref: GO:0004402 xref: GO:0004403 xref: GO:0004404 xref: GO:0046971 xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN is_a: CCO:F0000868 ! lysine N-acetyltransferase activity [Term] id: CCO:F0000814 name: H2A/H2B histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H2A and H2B." [GOC:jl, PMID:9241414] xref: EC:2.3.1.- xref: GO:0004405 is_a: CCO:F0000813 ! histone acetyltransferase activity [Term] id: CCO:F0000815 name: H3/H4 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H3 and H4." [GOC:jl, PMID:9241414] xref: EC:2.3.1.- xref: GO:0004406 is_a: CCO:F0000813 ! histone acetyltransferase activity [Term] id: CCO:F0000816 name: histone deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.-, http://cancerweb.ncl.ac.uk/] xref: EC:3.5.1.- xref: GO:0004407 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0005179 ! protein deacetylase activity [Term] id: CCO:F0000817 name: holocytochrome-c synthase activity namespace: molecular_function def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17] subset: gosubset_prok synonym: "cytochrome c heme-lyase activity" EXACT [EC:4.4.1.17] synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17] synonym: "holocytochrome c synthetase activity" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17] xref: EC:4.4.1.17 xref: GO:0004408 xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0000818 name: homoaconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxybutane-1,2,4-tricarboxylate = but-1-ene-1,2,4-tricarboxylate + H2O." [EC:4.2.1.36] subset: gosubset_prok synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36] synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.36] synonym: "cis-homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "HACN activity" EXACT [EC:4.2.1.36] synonym: "homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "Lys4" RELATED [EC:4.2.1.36] synonym: "LysF" RELATED [EC:4.2.1.36] xref: EC:4.2.1.36 xref: GO:0004409 xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000819 name: homocitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + 2-oxoglutarate = 2-hydroxybutane-1,2,4-tricarboxylate + CoA." [EC:2.3.3.14] comment: Note that this function was formerly EC:4.1.3.21. subset: gosubset_prok synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.14] synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" EXACT [EC:2.3.3.14] synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" EXACT [EC:2.3.3.14] synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" EXACT [EC:2.3.3.14] synonym: "homocitrate synthetase activity" EXACT [EC:2.3.3.14] xref: EC:2.3.3.14 xref: GO:0004410 xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0000820 name: homogentisate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate." [EC:1.13.11.5] subset: gosubset_prok synonym: "homogentisate dioxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisicase activity" EXACT [EC:1.13.11.5] xref: EC:1.13.11.5 xref: GO:0004411 xref: MetaCyc:HOMOGENTISATE-1 xref: Reactome:11355 xref: UM-BBD_enzymeID:e0081 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0000821 name: homoserine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3] subset: gosubset_prok xref: EC:1.1.1.3 xref: GO:0004412 xref: MetaCyc:HOMOSERDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000822 name: homoserine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine." [EC:2.7.1.39] subset: gosubset_prok synonym: "ATP:L-homoserine O-phosphotransferase activity" EXACT [EC:2.7.1.39] synonym: "homoserine kinase (phosphorylating)" EXACT [EC:2.7.1.39] synonym: "HSK" RELATED [EC:2.7.1.39] xref: EC:2.7.1.39 xref: GO:0004413 xref: MetaCyc:HOMOSERKIN-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004125 ! amino acid kinase activity [Term] id: CCO:F0000823 name: homoserine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine." [EC:2.3.1.31] subset: gosubset_prok synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine O-trans-acetylase activity" EXACT [EC:2.3.1.31] synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31] synonym: "homoserine-O-transacetylase activity" EXACT [EC:2.3.1.31] synonym: "L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] xref: EC:2.3.1.31 xref: GO:0004414 xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0000824 name: hyalurononglucosaminidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35] subset: gosubset_prok synonym: "chondroitinase activity" BROAD [EC:3.2.1.35] synonym: "chondroitinase I activity" EXACT [EC:3.2.1.35] synonym: "hyaluronate 4-glycanohydrolase activity" EXACT [EC:3.2.1.35] synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35] synonym: "hyaluronoglucosaminidase activity" EXACT [] synonym: "hyaluronoglucosidase activity" EXACT [EC:3.2.1.35] xref: EC:3.2.1.35 xref: GO:0004415 xref: MetaCyc:3.2.1.35-RXN is_a: CCO:F0003024 ! hexosaminidase activity [Term] id: CCO:F0000825 name: hydroxyacylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6] subset: gosubset_prok synonym: "acetoacetylglutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "glyoxalase II activity" EXACT [EC:3.1.2.6] synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "S-2-hydroxylacylglutathione hydrolase activity" EXACT [EC:3.1.2.6] xref: EC:3.1.2.6 xref: GO:0004416 xref: MetaCyc:GLYOXII-RXN is_a: CCO:F0003361 ! thiolester hydrolase activity [Term] id: CCO:F0000826 name: hydroxyethylthiazole kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-methyl-5-(2-hydroxyethyl)-thiazole = ADP + 4-methyl-5-(2-phosphoethyl)-thiazole." [EC:2.7.1.50] subset: gosubset_prok synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" EXACT [EC:2.7.1.50] synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" EXACT [EC:2.7.1.50] synonym: "hydroxyethylthiazole kinase (phosphorylating)" EXACT [EC:2.7.1.50] xref: EC:2.7.1.50 xref: GO:0004417 xref: MetaCyc:THIAZOLSYN3-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000827 name: hydroxymethylbilane synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3." [EC:2.5.1.61] comment: Note that this function was formerly EC:4.3.1.8. subset: gosubset_prok synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT [EC:2.5.1.61] synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "HMB-synthase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen ammonia-lyase (polymerizing)" EXACT [EC:2.5.1.61] synonym: "porphobilinogen deaminase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "pre-uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen synthetase activity" EXACT [EC:2.5.1.61] xref: EC:2.5.1.61 xref: GO:0004418 xref: MetaCyc:OHMETHYLBILANESYN-RXN xref: Reactome:11374 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0000828 name: hydroxymethylglutaryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate." [EC:4.1.3.4] subset: gosubset_prok synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.4] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "HMG-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4] xref: EC:4.1.3.4 xref: GO:0004419 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN xref: Reactome:74178 is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0000829 name: hydroxymethylglutaryl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+." [EC:1.1.1.34] subset: gosubset_prok synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34] synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34] xref: EC:1.1.1.34 xref: GO:0004420 xref: MetaCyc:1.1.1.34-RXN xref: Reactome:11408 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000830 name: hydroxymethylglutaryl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA." [EC:2.3.3.10] comment: Note that this function was formerly EC:4.1.3.5. subset: gosubset_prok synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.10] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "acetoacetyl coenzyme A transacetase activity" EXACT [EC:2.3.3.10] synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.10] synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "HMG-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" EXACT [EC:2.3.3.10] xref: EC:2.3.3.10 xref: GO:0004421 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN xref: Reactome:74169 is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0000831 name: hypoxanthine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate or GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] comment: Note that GO uses one molecular function term for consistency with Enzyme Nomenclature; also, all hypoxanthine phosphoribosyltransferases identified to date can act on either hypoxanthine or guanine, as well as xanthine or 6-mercaptopurine. subset: gosubset_prok synonym: "6-hydroxypurine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "6-mercaptopurine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "GPRT" RELATED [EC:2.4.2.8] synonym: "guanine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "guanosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "guanosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "guanylate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "guanylic pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "HGPRTase activity" EXACT [EC:2.4.2.8] synonym: "HPRT" RELATED [EC:2.4.2.8] synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "IMP diphosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP-GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "inosinate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic acid pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "purine-6-thiol phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "Transphosphoribosidase activity" EXACT [EC:2.4.2.8] xref: EC:2.4.2.8 xref: GO:0004422 xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN xref: Reactome:11410 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000832 name: iduronate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13] subset: gosubset_prok synonym: "2-sulfo-L-iduronate 2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13] synonym: "iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulphatase activity" EXACT [] synonym: "iduronide-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "idurono-2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate 2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" EXACT [EC:3.1.6.13] synonym: "L-idurono sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronosulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfo-L-iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfoiduronate sulfohydrolase activity" EXACT [EC:3.1.6.13] xref: EC:3.1.6.13 xref: GO:0004423 xref: MetaCyc:3.1.6.13-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0000833 name: imidazoleglycerol-phosphate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O." [EC:4.2.1.19] subset: gosubset_prok synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19] synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" EXACT [EC:4.2.1.19] synonym: "IGP dehydratase activity" EXACT [EC:4.2.1.19] synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT [] xref: EC:4.2.1.19 xref: GO:0004424 xref: MetaCyc:IMIDPHOSDEHYD-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000834 name: indole-3-glycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48] subset: gosubset_prok synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" EXACT [EC:4.1.1.48] synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48] synonym: "indole-3-glycerophosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthetase activity" EXACT [EC:4.1.1.48] xref: EC:4.1.1.48 xref: GO:0004425 xref: MetaCyc:IGPSYN-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000835 name: inorganic diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + H2O = 2 phosphate." [EC:3.6.1.1] subset: gosubset_prok synonym: "diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] synonym: "inorganic pyrophosphatase activity" EXACT [EC:3.6.1.1] synonym: "pyrophosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] xref: EC:3.6.1.1 xref: GO:0004427 xref: MetaCyc:INORGPYROPHOSPHAT-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0000836 name: inositol or phosphatidylinositol kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] subset: gosubset_prok synonym: "inositol/phosphatidylinositol kinase activity" EXACT [] xref: GO:0004428 is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0000837 name: 1-phosphatidylinositol 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate." [EC:2.7.1.67, PMID:9759495] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.67] synonym: "phosphatidylinositol 4-kinase activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67] synonym: "PI 4-kinase activity" EXACT [EC:2.7.1.67] synonym: "PI kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4-kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4K" BROAD [EC:2.7.1.67] synonym: "PI4K-alpha activity" BROAD [EC:2.7.1.67] synonym: "PtdIns-4-kinase activity" BROAD [EC:2.7.1.67] synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67] xref: EC:2.7.1.67 xref: GO:0004430 xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN is_a: CCO:F0000836 ! inositol or phosphatidylinositol kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000838 name: inositol or phosphatidylinositol phosphodiesterase activity namespace: molecular_function subset: gosubset_prok synonym: "inositol/phosphatidylinositol phosphodiesterase activity" EXACT [] xref: EC:3.1.4.- xref: GO:0004434 is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0000839 name: phosphoinositide phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." [EC:3.1.4.11] subset: gosubset_prok synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11] synonym: "phosphatidylinositol phospholipase C activity" EXACT [EC:3.1.4.11] synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED [] synonym: "phosphoinositidase C activity" EXACT [EC:3.1.4.11] synonym: "PI-PLC activity" EXACT [EC:3.1.4.11] synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11] xref: EC:3.1.4.11 xref: GO:0004435 xref: MetaCyc:3.1.4.11-RXN is_a: CCO:F0000838 ! inositol or phosphatidylinositol phosphodiesterase activity is_a: CCO:F0001003 ! phospholipase C activity [Term] id: CCO:F0000840 name: phosphatidylinositol diacylglycerol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13] comment: Note that this function was formerly EC:3.1.4.10. subset: gosubset_prok synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13] xref: EC:4.6.1.13 xref: GO:0004436 xref: MetaCyc:3.1.4.10-RXN is_a: CCO:F0003413 ! phosphorus-oxygen lyase activity [Term] id: CCO:F0000841 name: inositol or phosphatidylinositol phosphatase activity namespace: molecular_function def: "Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] subset: gosubset_prok synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT [] xref: GO:0004437 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0000842 name: phosphatidylinositol-3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64] comment: Note that this function includes EC:3.1.3.65. synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "inositol 1,3-bisphosphate phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,4,-bisphosphate 3-phosphatase activity" EXACT [] synonym: "inositol-polyphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] xref: EC:3.1.3.64 xref: GO:0004438 xref: GO:0016315 xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity is_a: CCO:F0005684 ! lipid phosphatase activity [Term] id: CCO:F0000843 name: phosphoinositide 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36] synonym: "diphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36] synonym: "inositol 1,4,5-triphosphate 5-phosphomonoesterase activity" EXACT [EC:3.1.3.36] synonym: "inositol triphosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.36] synonym: "IP(3) phosphatase activity" BROAD [EC:3.1.3.36] synonym: "IP3 phosphatase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidyl-inositol-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36] synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36] synonym: "polyphosphoinositol lipid 5-phosphatase activity" BROAD [EC:3.1.3.36] synonym: "PtdIns(4,5)P(2) phosphatase activity" EXACT [EC:3.1.3.36] synonym: "PtdIns(4,5)P2 phosphatase activity" EXACT [EC:3.1.3.36] synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36] synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36] synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [EC:3.1.3.36] synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" RELATED [EC:3.1.3.36] xref: EC:3.1.3.36 xref: GO:0004439 xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity is_a: CCO:F0005684 ! lipid phosphatase activity [Term] id: CCO:F0000844 name: inositol-1,4-bisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb] synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.57] synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57] synonym: "inositol-polyphosphate 1-phosphatase activity" EXACT [EC:3.1.3.57] xref: EC:3.1.3.57 xref: GO:0004441 xref: MetaCyc:3.1.3.57-RXN is_a: CCO:F0003119 ! inositol bisphosphate phosphatase activity [Term] id: CCO:F0000845 name: inositol-polyphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56] synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.56] synonym: "5PTase activity" RELATED [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "inositol polyphosphate-5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inositol trisphosphate phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [] synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,4,5)P3 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] xref: EC:3.1.3.56 xref: GO:0004445 xref: MetaCyc:3.1.3.56-RXN is_a: CCO:F0006172 ! inositol trisphosphate phosphatase activity [Term] id: CCO:F0000846 name: multiple inositol-polyphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62] synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.62] synonym: "inositol tetrakisphosphate phosphomonoesterase activity" EXACT [EC:3.1.3.62] synonym: "MIPP activity" EXACT [EC:3.1.3.62] xref: EC:3.1.3.62 xref: GO:0004446 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity [Term] id: CCO:F0000847 name: iodide peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O." [EC:1.11.1.8] synonym: "iodide peroxidase-tyrosine iodinase activity" EXACT [EC:1.11.1.8] synonym: "iodide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.8] synonym: "iodinase activity" RELATED [EC:1.11.1.8] synonym: "iodoperoxidase (heme type)" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodase activity" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "monoiodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8] synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8] synonym: "TPO activity" RELATED [EC:1.11.1.8] synonym: "tyrosine iodinase activity" EXACT [EC:1.11.1.8] xref: EC:1.11.1.8 xref: GO:0004447 xref: MetaCyc:IODIDE-PEROXIDASE-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0000848 name: isocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42] subset: gosubset_prok synonym: "beta-ketoglutaric-isocitric carboxylase activity" EXACT [EC:1.1.1.-] synonym: "IDH activity" EXACT [EC:1.1.1.-] synonym: "IDP activity" EXACT [EC:1.1.1.-] synonym: "IDP1" RELATED [EC:1.1.1.-] synonym: "IDP2" RELATED [EC:1.1.1.-] synonym: "IDP3" RELATED [EC:1.1.1.-] synonym: "isocitric acid dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "isocitric dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate carboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate decarboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalsuccinic decarboxylase activity" EXACT [EC:1.1.1.-] xref: EC:1.1.1.- xref: GO:0004448 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000849 name: isocitrate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41] subset: gosubset_prok synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41] synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41] synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] xref: EC:1.1.1.41 xref: GO:0004449 xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-(NAD+)-RXN xref: Reactome:11496 is_a: CCO:F0000848 ! isocitrate dehydrogenase activity [Term] id: CCO:F0000850 name: isocitrate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42] subset: gosubset_prok synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] synonym: "isocitrate (NADP) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP-dependent) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.42] synonym: "NADP isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-ICDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-IDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase- activity" RELATED [EC:1.1.1.42] xref: EC:1.1.1.42 xref: GO:0004450 xref: MetaCyc:ISOCITDEH-RXN is_a: CCO:F0000848 ! isocitrate dehydrogenase activity [Term] id: CCO:F0000851 name: isocitrate lyase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate = succinate + glyoxylate." [EC:4.1.3.1] subset: gosubset_prok synonym: "ICL activity" EXACT [EC:4.1.3.1] synonym: "isocitrase activity" EXACT [EC:4.1.3.1] synonym: "isocitratase activity" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase (succinate-forming)" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] synonym: "isocitritase activity" EXACT [EC:4.1.3.1] synonym: "threo-DS-isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] xref: EC:4.1.3.1 xref: GO:0004451 xref: MetaCyc:ISOCIT-CLEAV-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0000852 name: isopentenyl-diphosphate delta-isomerase activity namespace: molecular_function def: "Catalysis of the isomerization of isopentenyl diphosphate into dimethylallyl diphosphate." [EC:5.3.3.2] subset: gosubset_prok synonym: "IPP isomerase activity" EXACT [EC:5.3.3.2] synonym: "ipp isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT [] synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate delta-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate Delta-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] synonym: "methylbutenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] xref: EC:5.3.3.2 xref: GO:0004452 xref: MetaCyc:IPPISOM-RXN xref: Reactome:11501 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0000853 name: juvenile-hormone esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59, EMBL:AF304352] synonym: "JH esterase activity" EXACT [EC:3.1.1.59] synonym: "JH-esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone analog esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone carboxyesterase activity" EXACT [EC:3.1.1.59] synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" EXACT [EC:3.1.1.59] xref: EC:3.1.1.59 xref: GO:0004453 xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0000854 name: ketohexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3] subset: gosubset_prok synonym: "ATP:D-fructose 1-phosphotransferase activity" EXACT [EC:2.7.1.3] synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3] synonym: "ketohexokinase (phosphorylating)" EXACT [EC:2.7.1.3] xref: EC:2.7.1.3 xref: GO:0004454 xref: MetaCyc:KETOHEXOKINASE-RXN xref: Reactome:11506 is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0000855 name: ketol-acid reductoisomerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86] subset: gosubset_prok synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.86] synonym: "2-hydroxy-3-keto acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetolactate reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" EXACT [EC:1.1.1.86] synonym: "isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86] xref: EC:1.1.1.86 xref: GO:0004455 xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000856 name: phosphogluconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O." [EC:4.2.1.12] subset: gosubset_prok synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" EXACT [EC:4.2.1.12] synonym: "6-phospho-D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydrase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconic dehydrase activity" EXACT [EC:4.2.1.12] synonym: "gluconate 6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "gluconate-6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] xref: EC:4.2.1.12 xref: GO:0004456 xref: MetaCyc:PGLUCONDEHYDRAT-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000857 name: lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidation of lactate to produce pyruvate." [GOC:ai] subset: gosubset_prok xref: GO:0004457 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0000858 name: D-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4] subset: gosubset_prok synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-(-)-lactic cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate (cytochrome) dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4] xref: EC:1.1.2.4 xref: GO:0004458 xref: MetaCyc:D-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN is_a: CCO:F0000857 ! lactate dehydrogenase activity is_a: CCO:F0003456 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: CCO:F0000859 name: L-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27] subset: gosubset_prok synonym: "L-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.27] synonym: "L-lactic dehydrogenase activity" EXACT [EC:1.1.1.27] xref: EC:1.1.1.27 xref: GO:0004459 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN xref: Reactome:11515 is_a: CCO:F0000857 ! lactate dehydrogenase activity is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000860 name: L-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.3] subset: gosubset_prok synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "cytochrome b2" RELATED [] synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3] synonym: "dehydrogenase, lactate (cytochrome)" EXACT [EC:1.1.2.3] synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3] synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c reductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "lactate dehydrogenase (cytochrome)" EXACT [EC:1.1.2.3] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3] synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3] xref: EC:1.1.2.3 xref: GO:0004460 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN is_a: CCO:F0000857 ! lactate dehydrogenase activity is_a: CCO:F0003456 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: CCO:F0000861 name: lactose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22] synonym: "lactose synthetase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] xref: EC:2.4.1.22 xref: GO:0004461 xref: MetaCyc:LACTOSE-SYNTHASE-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0000862 name: lactoylglutathione lyase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5] subset: gosubset_prok synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" EXACT [EC:4.4.1.5] synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" EXACT [EC:4.4.1.5] synonym: "aldoketomutase activity" EXACT [EC:4.4.1.5] synonym: "glyoxalase I activity" EXACT [EC:4.4.1.5] synonym: "glyoxylase I" RELATED [EC:4.4.1.5] synonym: "ketone-aldehyde mutase activity" EXACT [EC:4.4.1.5] synonym: "methylglyoxalase activity" EXACT [EC:4.4.1.5] xref: EC:4.4.1.5 xref: GO:0004462 xref: MetaCyc:GLYOXI-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0000863 name: leukotriene-A4 hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate." [EC:3.3.2.6] subset: gosubset_prok synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A(4) hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA-4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4H" RELATED [EC:3.3.2.6] xref: EC:3.3.2.6 xref: GO:0004463 xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN is_a: CCO:F0003373 ! ether hydrolase activity [Term] id: CCO:F0000864 name: leukotriene-C4 synthase activity namespace: molecular_function def: "Catalysis of the reaction: leukotriene C4 = leukotriene A4 + glutathione." [EC:2.5.1.37] comment: Note that this function was EC:2.5.1.37. synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" EXACT [EC:4.4.1.20] synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" EXACT [EC:4.4.1.20] synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C4 synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthetase activity" EXACT [EC:4.4.1.20] xref: EC:4.4.1.20 xref: GO:0004464 xref: MetaCyc:LEUKOTRIENE-C(4)-SYNTHASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0000865 name: lipoprotein lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.34] synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34] synonym: "diacylglycerol hydrolase activity" EXACT [EC:3.1.1.34] synonym: "diacylglycerol lipase activity" EXACT [EC:3.1.1.34] synonym: "diglyceride lipase activity" EXACT [EC:3.1.1.34] synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34] synonym: "postheparin esterase activity" EXACT [EC:3.1.1.34] synonym: "postheparin lipase activity" EXACT [EC:3.1.1.34] synonym: "triacylglycero-protein acylhydrolase activity" EXACT [EC:3.1.1.34] xref: EC:3.1.1.34 xref: GO:0004465 xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN xref: Reactome:11541 is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0003111 ! lipase activity [Term] id: CCO:F0000866 name: long-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF." [EC:1.3.99.13] subset: gosubset_prok synonym: "long-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] synonym: "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] synonym: "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] synonym: "palmitoyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.13] synonym: "palmitoyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] xref: EC:1.3.99.13 xref: GO:0004466 xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN is_a: CCO:F0000480 ! acyl-CoA dehydrogenase activity [Term] id: CCO:F0000867 name: long-chain-fatty-acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18." [EC:6.2.1.3] subset: gosubset_prok synonym: "ACS3" NARROW [EC:6.2.1.3] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.3] synonym: "acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "FAA1" NARROW [EC:6.2.1.3] synonym: "fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3] synonym: "fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3] synonym: "LCFA synthetase activity" EXACT [EC:6.2.1.3] synonym: "lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3] synonym: "long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase activity" EXACT [] synonym: "long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain fatty acid activation" RELATED [] synonym: "long-chain fatty acid-CoA ligase activity" EXACT [] synonym: "long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT [] synonym: "oleoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA ligase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA synthase" NARROW [EC:6.2.1.3] synonym: "pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "stearoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "thiokinase" RELATED [EC:6.2.1.3] xref: EC:6.2.1.3 xref: GO:0004467 xref: MetaCyc:ACYLCOASYN-RXN xref: MetaCyc:PWY-5143 xref: Reactome:11544 xref: UM-BBD_enzymeID:e0025 is_a: CCO:F0002996 ! fatty-acid ligase activity [Term] id: CCO:F0000868 name: lysine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32] subset: gosubset_prok synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "LAT activity" EXACT [EC:2.3.1.32] synonym: "lysine acetyltransferase activity" EXACT [] synonym: "lysine N(6)-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] xref: EC:2.3.1.32 xref: GO:0004468 xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0000869 name: malic enzyme activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyruvic-malic carboxylase activity" EXACT [EC:1.1.1.39] xref: GO:0004470 is_a: CCO:F0003217 ! malate dehydrogenase activity [Term] id: CCO:F0000870 name: malate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate." [EC:1.1.1.39] subset: gosubset_prok synonym: "'malic' enzyme" RELATED [EC:1.1.1.39] synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.39] synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.39] synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.39] xref: EC:1.1.1.39 xref: GO:0004471 xref: MetaCyc:1.1.1.39-RXN is_a: CCO:F0000869 ! malic enzyme activity is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000871 name: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate." [EC:1.1.1.40] subset: gosubset_prok synonym: "'malic' enzyme" RELATED [EC:1.1.1.40] synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.40] synonym: "L-malate:NADP oxidoreductase activity" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (decarboxylating, NADP)" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (NADP, decarboxylating)" EXACT [EC:1.1.1.40] synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40] synonym: "NADP-malic enzyme activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malate dehydrogenase activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40] xref: EC:1.1.1.40 xref: GO:0004473 xref: MetaCyc:MALIC-NADP-RXN is_a: CCO:F0000869 ! malic enzyme activity is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000872 name: malate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + glyoxylate = L-malate + CoA." [EC:2.3.3.9] comment: Note that this function was formerly EC:4.1.3.2. subset: gosubset_prok synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetylase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylic transacetase activity" EXACT [EC:2.3.3.9] synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.9] synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9] synonym: "malate synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9] xref: EC:2.3.3.9 xref: GO:0004474 xref: MetaCyc:MALSYN-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0000873 name: mannose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose." [EC:2.7.7.13] subset: gosubset_prok synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13] synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine diphosphomannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" EXACT [EC:2.7.7.13] synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13] xref: EC:2.7.7.13 xref: GO:0004475 xref: MetaCyc:2.7.7.13-RXN is_a: CCO:F0002242 ! mannose-phosphate guanylyltransferase activity [Term] id: CCO:F0000874 name: mannose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8] subset: gosubset_prok synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.8] synonym: "D-mannose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.8] synonym: "mannose phosphate isomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8] synonym: "phosphomannoisomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphomannose isomerase activity" EXACT [EC:5.3.1.8] xref: EC:5.3.1.8 xref: GO:0004476 xref: MetaCyc:MANNPISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0000875 name: methenyltetrahydrofolate cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9] subset: gosubset_prok synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" EXACT [EC:3.5.4.9] synonym: "citrovorum factor cyclodehydrase activity" EXACT [EC:3.5.4.9] synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" EXACT [EC:3.5.4.9] xref: EC:3.5.4.9 xref: GO:0004477 xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN is_a: CCO:F0004139 ! cyclohydrolase activity [Term] id: CCO:F0000876 name: methionine adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] subset: gosubset_prok synonym: "adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "AdoMet synthetase activity" EXACT [EC:2.5.1.6] synonym: "ATP-methionine adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "ATP:L-methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6] synonym: "S-adenosyl-L-methionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] xref: EC:2.5.1.6 xref: GO:0004478 xref: MetaCyc:S-ADENMETSYN-RXN xref: Reactome:11567 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0000877 name: methionyl-tRNA formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "formylmethionyl-transfer ribonucleic synthetase activity" EXACT [EC:2.1.2.9] synonym: "methionyl ribonucleic formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer RNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA Met formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] xref: EC:2.1.2.9 xref: GO:0004479 xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN is_a: CCO:F0003318 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: CCO:F0000878 name: methylene-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" EXACT [EC:2.1.1.16] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16] xref: EC:2.1.1.16 xref: GO:0004481 xref: MetaCyc:2.1.1.16-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0000879 name: mRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56] synonym: "guanine-7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger RNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.56] xref: EC:2.1.1.56 xref: GO:0004482 xref: MetaCyc:MRNA-(GUANINE-N7-)-METHYLTRANSFERASE-RXN xref: Reactome:72079 is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0001761 ! mRNA methyltransferase activity [Term] id: CCO:F0000880 name: mRNA (nucleoside-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57] subset: gosubset_prok synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] xref: EC:2.1.1.57 xref: GO:0004483 xref: MetaCyc:2.1.1.57-RXN is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0001761 ! mRNA methyltransferase activity [Term] id: CCO:F0000881 name: mRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50] synonym: "GTP--RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "GTP:mRNA guanylyltransferase activity" EXACT [] synonym: "messenger RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50] synonym: "protein lambda2" RELATED [EC:2.7.7.50] xref: EC:2.7.7.50 xref: GO:0004484 xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN xref: Reactome:80327 is_a: CCO:F0001772 ! RNA guanylyltransferase activity [Term] id: CCO:F0000882 name: methylcrotonoyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-methylcrotonyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA." [EC:6.4.1.4] subset: gosubset_prok synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] xref: EC:6.4.1.4 xref: GO:0004485 xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN xref: Reactome:11585 is_a: CCO:F0003144 ! CoA carboxylase activity [Term] id: CCO:F0000883 name: methylenetetrahydrofolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.-, EC:1.5.1.15] subset: gosubset_prok synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1.- xref: GO:0004486 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000884 name: methylenetetrahydrofolate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+." [EC:1.5.1.15] synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" EXACT [EC:1.5.1.15] xref: EC:1.5.1.15 xref: GO:0004487 xref: MetaCyc:1.5.1.15-RXN is_a: CCO:F0000883 ! methylenetetrahydrofolate dehydrogenase activity [Term] id: CCO:F0000885 name: methylenetetrahydrofolate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+." [EC:1.5.1.5] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1.5 xref: GO:0004488 xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN is_a: CCO:F0000883 ! methylenetetrahydrofolate dehydrogenase activity [Term] id: CCO:F0000886 name: methylenetetrahydrofolate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20] comment: Includes EC 1.7.99.5. subset: gosubset_prok synonym: "1.7.99.5" RELATED [] synonym: "5,10-CH(2)-H(4)folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-CH2-H4folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "MetF" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH2)" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "MTHFR activity" BROAD [EC:1.5.1.20] synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N5,10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] synonym: "N5,N10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] xref: EC:1.5.1.20 xref: GO:0004489 xref: GO:0008702 xref: MetaCyc:1.5.1.20-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000887 name: methylglutaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O." [EC:4.2.1.18] subset: gosubset_prok synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" EXACT [EC:4.2.1.18] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.18] synonym: "3-methylglutaconyl CoA hydratase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.18] xref: EC:4.2.1.18 xref: GO:0004490 xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0000888 name: methylmalonate-semialdehyde dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27] subset: gosubset_prok synonym: "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)" EXACT [EC:1.2.1.27] synonym: "MMSA dehydrogenase activity" EXACT [EC:1.2.1.27] synonym: "MSDH activity" EXACT [EC:1.2.1.27] xref: EC:1.2.1.27 xref: GO:0004491 xref: MetaCyc:1.2.1.27-RXN xref: Reactome:70889 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000889 name: methylmalonyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2." [EC:4.1.1.41] subset: gosubset_prok synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" EXACT [EC:4.1.1.41] synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] synonym: "methylmalonyl-coenzyme A decarboxylase activity" EXACT [EC:4.1.1.41] xref: EC:4.1.1.41 xref: GO:0004492 xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000890 name: methylmalonyl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = (S)-2-methyl-3-oxopropanoyl-CoA." [EC:5.1.99.1] subset: gosubset_prok synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "DL-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] synonym: "dl-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl coenzyme A racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] xref: EC:5.1.99.1 xref: GO:0004493 xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN xref: Reactome:11610 is_a: CCO:F0003417 ! racemase and epimerase activity [Term] id: CCO:F0000891 name: methylmalonyl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = succinyl-CoA." [EC:5.4.99.2] subset: gosubset_prok synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(S)-methylmalonyl-CoA mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" EXACT [EC:5.4.99.2] xref: EC:5.4.99.2 xref: GO:0004494 xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN xref: Reactome:11612 is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0000892 name: mevaldate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33] xref: EC:1.1.1.- xref: GO:0004495 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000893 name: mevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate." [EC:2.7.1.36] subset: gosubset_prok synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "ATP:mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate kinase (phosphorylating)" EXACT [EC:2.7.1.36] synonym: "mevalonate phosphokinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic acid kinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic kinase activity" EXACT [EC:2.7.1.36] synonym: "MVA kinase activity" EXACT [EC:2.7.1.36] xref: EC:2.7.1.36 xref: GO:0004496 xref: MetaCyc:MEVALONATE-KINASE-RXN xref: Reactome:11620 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000894 name: monooxygenase activity namespace: molecular_function def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok xref: GO:0004497 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0000895 name: calcidiol 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [EC:1.14.13.13] synonym: "1-hydroxylase-25-hydroxyvitamin D3" RELATED [EC:1.14.13.13] synonym: "25-hydroxy D3-1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-OHD-1 alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.13] synonym: "cytochrome P450 CYP27B" NARROW [] xref: EC:1.14.13.13 xref: GO:0004498 xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000896 name: flavin-containing monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8] subset: gosubset_prok synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT [] synonym: "dimethylaniline N-oxidase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline oxidase activity" EXACT [EC:1.13.12.11] synonym: "DMA oxidase activity" EXACT [EC:1.13.12.11] synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "flavin mixed function oxidase activity" RELATED [EC:1.13.12.11] synonym: "flavin monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "FMO activity" RELATED [EC:1.13.12.11] synonym: "FMO-I" RELATED [EC:1.13.12.11] synonym: "FMO-II" RELATED [EC:1.13.12.11] synonym: "FMO1" RELATED [EC:1.13.12.11] synonym: "FMO2" RELATED [EC:1.13.12.11] synonym: "FMO3" RELATED [EC:1.13.12.11] synonym: "FMO4" RELATED [EC:1.13.12.11] synonym: "FMO5" RELATED [EC:1.13.12.11] synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT [] synonym: "mixed-function amine oxidase activity" RELATED [EC:1.13.12.11] synonym: "N,N-dimethylaniline monooxygenase activity" EXACT [EC:1.13.12.11] synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" EXACT [EC:1.13.12.11] synonym: "Ziegler's enzyme" RELATED [EC:1.13.12.11] xref: EC:1.14.13.8 xref: GO:0004499 xref: GO:0047076 xref: MetaCyc:1.14.13.8-RXN xref: Reactome:11625 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000897 name: dopamine beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1] subset: gosubset_prok synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" EXACT [EC:1.14.17.1] synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopa beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine b-hydroxylase activity" EXACT [] synonym: "dopamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopamine hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine-B-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] synonym: "oxygenase, dopamine beta-mono-" EXACT [EC:1.14.17.1] synonym: "phenylamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] xref: EC:1.14.17.1 xref: GO:0004500 xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN is_a: CCO:F0003298 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000898 name: ecdysone 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ecdysone + donor-H2 + O2 = 20-hydroxyecdysone + acceptor + H2O." [EC:1.14.99.22] synonym: "alpha-ecdysone C-20 hydroxylase activity" EXACT [EC:1.14.99.22] synonym: "ecdysone 20-hydroxylase activity" EXACT [] synonym: "ecdysone modification" BROAD [] synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.99.22] xref: EC:1.14.99.22 xref: GO:0004501 xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0000899 name: kynurenine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O." [EC:1.14.13.9] subset: gosubset_prok synonym: "kynurenine 3-hydroxylase activity" EXACT [] synonym: "kynurenine hydroxylase activity" EXACT [EC:1.14.13.9] synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.9] synonym: "L-kynurenine-3-hydroxylase activity" EXACT [EC:1.14.13.9] xref: EC:1.14.13.9 xref: GO:0004502 xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN xref: Reactome:12242 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000900 name: monophenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1] subset: gosubset_prok synonym: "catecholase" BROAD [EC:1.14.18.1] synonym: "chlorogenic acid oxidase activity" EXACT [EC:1.14.18.1] synonym: "chlorogenic oxidase activity" EXACT [EC:1.14.18.1] synonym: "cresolase activity" EXACT [EC:1.14.18.1] synonym: "dopa oxidase" BROAD [EC:1.14.18.1] synonym: "monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol monooxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxygenase" EXACT [PMID:2494997] synonym: "monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol,L-dopa:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenolase activity" EXACT [EC:1.14.18.1] synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol oxidase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol oxidoreductase" BROAD [EC:1.14.18.1] synonym: "o-diphenol:O2 oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.14.18.1] synonym: "phenol oxidase activity" EXACT [] synonym: "phenolase activity" BROAD [EC:1.14.18.1] synonym: "polyaromatic oxidase activity" EXACT [EC:1.14.18.1] synonym: "polyphenolase activity" EXACT [EC:1.14.18.1] synonym: "prophenol oxidase" RELATED [] synonym: "pyrocatechol oxidase" BROAD [EC:1.14.18.1] synonym: "tyrosinase activity" BROAD [EC:1.14.18.1] synonym: "tyrosine-dopa oxidase activity" EXACT [EC:1.14.18.1] xref: EC:1.14.18.1 xref: GO:0004503 xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN is_a: CCO:F0003299 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000901 name: peptidylglycine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3] subset: gosubset_prok synonym: "PAM activity" EXACT [EC:1.14.17.3] synonym: "PAM-A" RELATED [EC:1.14.17.3] synonym: "PAM-B" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amide synthase activity" EXACT [EC:1.14.17.3] synonym: "peptide-alpha-amide synthetase activity" EXACT [EC:1.14.17.3] synonym: "peptidyl alpha-amidating enzyme activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine 2-hydroxylase activity" EXACT [] synonym: "peptidylglycine alpha-amidating monooxygenase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine alpha-hydroxylase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.17.3] synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3] xref: EC:1.14.17.3 xref: GO:0004504 xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN is_a: CCO:F0003298 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000902 name: phenylalanine 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1] subset: gosubset_prok synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.1] synonym: "PAH activity" EXACT [EC:1.14.16.1] synonym: "phenylalaninase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine 4-hydroxylase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine hydroxylase activity" EXACT [] xref: EC:1.14.16.1 xref: GO:0004505 xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN xref: Reactome:12249 is_a: CCO:F0003297 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000903 name: squalene monooxygenase activity namespace: molecular_function def: "Catalysis of the formation of a 2,3-epoxide in squalene." [EC:1.14.99.7] synonym: "squalene 2,3-oxidocyclase activity" EXACT [EC:1.14.99.7] synonym: "squalene epoxidase activity" EXACT [EC:1.14.99.7] synonym: "squalene hydroxylase activity" EXACT [] synonym: "squalene oxydocyclase activity" EXACT [EC:1.14.99.7] synonym: "squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.7] synonym: "squalene-2,3-epoxidase activity" EXACT [EC:1.14.99.7] synonym: "squalene-2,3-epoxide cyclase activity" EXACT [EC:1.14.99.7] xref: EC:1.14.99.7 xref: GO:0004506 xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN xref: Reactome:12251 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0000904 name: steroid 11-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4] synonym: "cytochrome P450 CYP11B1" NARROW [] synonym: "cytochrome P450 CYP11B2" NARROW [] synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4] synonym: "oxygenase, steroid 11beta -mono-" EXACT [EC:1.14.15.4] synonym: "steroid 11-beta-hydroxylase activity" EXACT [] synonym: "steroid 11-beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-monooxygenase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" EXACT [EC:1.14.15.4] xref: EC:1.14.15.4 xref: GO:0004507 xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000905 name: steroid 17-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9] synonym: "17alpha-hydroxylase-C17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.99.9] synonym: "cytochrome P450 CYP17" NARROW [] synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.99.9] synonym: "cytochrome P45017alpha" RELATED [EC:1.14.99.9] synonym: "steroid 17-alpha-hydroxylase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alpha-hydroxylase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alpha-monooxygenase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alphahydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" EXACT [EC:1.14.99.9] xref: EC:1.14.99.9 xref: GO:0004508 xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0000906 name: steroid 21-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O." [EC:1.14.99.10] synonym: "21-hydroxylase activity" EXACT [EC:1.14.99.10] synonym: "cytochrome P450 CYP21A1" NARROW [] synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.99.10] synonym: "steroid 21-hydroxylase activity" EXACT [] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" EXACT [EC:1.14.99.10] xref: EC:1.14.99.10 xref: GO:0004509 xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0000907 name: tryptophan 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4] synonym: "indoleacetic acid-5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "L-tryptophan hydroxylase activity" EXACT [] synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.16.4] synonym: "tryptophan 5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "tryptophan hydroxylase activity" EXACT [EC:1.14.16.4] xref: EC:1.14.16.4 xref: GO:0004510 xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN is_a: CCO:F0003297 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000908 name: tyrosine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2] synonym: "L-tyrosine hydroxylase activity" EXACT [EC:1.14.16.2] synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.2] synonym: "tyrosine 3-hydroxylase activity" EXACT [] synonym: "tyrosine hydroxylase activity" EXACT [] xref: EC:1.14.16.2 xref: GO:0004511 xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN is_a: CCO:F0003297 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000909 name: inositol-3-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate; requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4] subset: gosubset_prok synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" EXACT [EC:5.5.1.4] synonym: "D-glucose 6-phosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucocycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucose 6-phosphate cyclase activity" EXACT [EC:5.5.1.4] synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthatase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthetase activity" EXACT [EC:5.5.1.4] synonym: "myo-inositol-1-phosphate synthase activity" EXACT [] xref: EC:5.5.1.4 xref: GO:0004512 xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0000910 name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10] synonym: "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "SAT-3" RELATED [EC:2.4.99.10] synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10] xref: EC:2.4.99.10 xref: GO:0004513 xref: MetaCyc:2.4.99.10-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0000911 name: nicotinate-nucleotide diphosphorylase (carboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.19] subset: gosubset_prok synonym: "NAD pyrophosphorylase activity" EXACT [EC:2.4.2.19] synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT [] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "QAPRTase activity" EXACT [EC:2.4.2.19] synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" EXACT [EC:2.4.2.19] synonym: "quinolinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] synonym: "quinolinic phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] xref: EC:2.4.2.19 xref: GO:0004514 xref: MetaCyc:QUINOPRIBOTRANS-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000912 name: nicotinate-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18] subset: gosubset_prok synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) diphosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "NaMN-ATase activity" EXACT [EC:2.7.7.18] synonym: "nicotinate mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW [] xref: EC:2.7.7.18 xref: GO:0004515 xref: MetaCyc:NICONUCADENYLYLTRAN-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000913 name: nicotinate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.11] subset: gosubset_prok synonym: "niacin ribonucleotidase activity" EXACT [EC:2.4.2.11] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.11] synonym: "nicotinic acid mononucleotide glycohydrolase activity" EXACT [EC:2.4.2.11] synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.11] synonym: "nicotinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.11] xref: EC:2.4.2.11 xref: GO:0004516 xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000914 name: nitric-oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39] subset: gosubset_prok synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39] synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39] synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" EXACT [EC:1.14.13.39] synonym: "NADPH-diaphorase activity" EXACT [EC:1.14.13.39] synonym: "nitric oxide synthase activity" EXACT [] synonym: "nitric oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "nitric-oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "NO synthase activity" EXACT [EC:1.14.13.39] xref: EC:1.14.13.39 xref: GO:0004517 xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0000915 name: nuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] comment: Consider also annotating to the molecular function term 'nucleic acid binding ; GO:0003676'. subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: EC:3.1.-.- xref: GO:0004518 is_a: CCO:F0003360 ! hydrolase activity, acting on ester bonds [Term] id: CCO:F0000916 name: endonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: GO:0004519 xref: Reactome:3138 is_a: CCO:F0000915 ! nuclease activity [Term] id: CCO:F0000917 name: endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "endonuclease G activity" NARROW [] xref: GO:0004520 xref: Reactome:3136 is_a: CCO:F0000916 ! endonuclease activity is_a: CCO:F0000932 ! deoxyribonuclease activity [Term] id: CCO:F0000918 name: endoribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "endonuclease G activity" NARROW [] xref: GO:0004521 is_a: CCO:F0000916 ! endonuclease activity is_a: CCO:F0000934 ! ribonuclease activity [Term] id: CCO:F0000919 name: pancreatic ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.5] synonym: "alkaline ribonuclease activity" EXACT [EC:3.1.27.5] synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT [EC:3.1.27.5] synonym: "endoribonuclease I" RELATED [EC:3.1.27.5] synonym: "gene S glycoproteins" RELATED [EC:3.1.27.5] synonym: "gene S locus-specific glycoproteins" RELATED [EC:3.1.27.5] synonym: "pancreatic RNase activity" EXACT [EC:3.1.27.5] synonym: "ribonuclease A" EXACT [] synonym: "ribonuclease I activity" EXACT [EC:3.1.27.5] synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT [EC:3.1.27.5] synonym: "ribonucleic phosphatase activity" EXACT [EC:3.1.27.5] synonym: "RNase A activity" EXACT [EC:3.1.27.5] synonym: "RNase activity" BROAD [EC:3.1.27.5] synonym: "RNase I activity" EXACT [EC:3.1.27.5] synonym: "S-genotype-asssocd. glycoproteins" RELATED [EC:3.1.27.5] synonym: "SLSG glycoproteins" RELATED [EC:3.1.27.5] xref: EC:3.1.27.5 xref: GO:0004522 xref: MetaCyc:3.1.27.5-RXN is_a: CCO:F0003450 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0000920 name: ribonuclease H activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. subset: gosubset_prok synonym: "calf thymus ribonuclease H activity" EXACT [] synonym: "endoribonuclease H" RELATED [EC:3.1.26.4] synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4] synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4] synonym: "hybrid nuclease activity" EXACT [EC:3.1.26.4] synonym: "hybrid ribonuclease activity" EXACT [EC:3.1.26.4] synonym: "hybridase (ribonuclease H)" EXACT [EC:3.1.26.4] synonym: "hybridase activity" EXACT [EC:3.1.26.4] synonym: "ribonuclease H1 activity" NARROW [] synonym: "ribonuclease H2 activity" NARROW [] synonym: "ribonuclease H3 activity" NARROW [] synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" EXACT [EC:3.1.26.4] synonym: "RNase H activity" EXACT [] synonym: "RNase H1 activity" NARROW [] synonym: "RNase H2 activity" NARROW [] synonym: "RNase H3 activity" NARROW [] xref: EC:3.1.26.4 xref: GO:0004523 xref: GO:0004524 xref: MetaCyc:3.1.26.4-RXN xref: Reactome:12321 is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0000921 name: ribonuclease III activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] subset: gosubset_prok synonym: "pre-mRNA 3'-end processing endonuclease" NARROW [] synonym: "ribonuclease 3 activity" EXACT [EC:3.1.26.3] synonym: "RNase III activity" EXACT [EC:3.1.26.3] xref: EC:3.1.26.3 xref: GO:0004525 xref: MetaCyc:3.1.26.3-RXN is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0000922 name: ribonuclease P activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] subset: gosubset_prok synonym: "RNase P" EXACT [] xref: EC:3.1.26.5 xref: GO:0004526 xref: MetaCyc:3.1.26.5-RXN is_a: CCO:F0000935 ! tRNA-specific ribonuclease activity is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0000923 name: exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: GO:0004527 is_a: CCO:F0000915 ! nuclease activity [Term] id: CCO:F0000924 name: phosphodiesterase I activity namespace: molecular_function def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1] subset: gosubset_prok synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1] synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1] synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDE activity" RELATED [EC:3.1.4.1] synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'NPDE activity" RELATED [EC:3.1.4.1] synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "exonuclease I activity" RELATED [EC:3.1.4.1] synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "oligonucleate 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.1] synonym: "orthophosphoric diester phosphohydrolase activity" EXACT [EC:3.1.4.1] synonym: "PDE I activity" EXACT [EC:3.1.4.1] synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1] xref: EC:3.1.4.1 xref: GO:0004528 xref: MetaCyc:3.1.4.1-RXN is_a: CCO:F0000923 ! exonuclease activity is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0000925 name: exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: GO:0004529 is_a: CCO:F0000923 ! exonuclease activity is_a: CCO:F0000932 ! deoxyribonuclease activity [Term] id: CCO:F0000926 name: deoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1] subset: gosubset_prok synonym: "alkaline deoxyribonuclease activity" EXACT [EC:3.1.21.1] synonym: "alkaline DNase activity" EXACT [EC:3.1.21.1] synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1] synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1] synonym: "deoxyribonucleic phosphatase activity" EXACT [EC:3.1.21.1] synonym: "DNA depolymerase activity" EXACT [EC:3.1.21.1] synonym: "DNA endonuclease activity" EXACT [EC:3.1.21.1] synonym: "DNA nuclease activity" EXACT [EC:3.1.21.1] synonym: "DNAase activity" EXACT [EC:3.1.21.1] synonym: "DNase activity" NARROW [EC:3.1.21.1] synonym: "DNase I" RELATED [EC:3.1.21.1] synonym: "dornava" RELATED [EC:3.1.21.1] synonym: "dornavac" RELATED [EC:3.1.21.1] synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1] synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1] synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1] synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1] synonym: "pancreatic dornase" NARROW [EC:3.1.21.1] synonym: "thymonuclease activity" NARROW [EC:3.1.21.1] synonym: "thymonuclease, dornase activity" EXACT [EC:3.1.21.1] xref: EC:3.1.21.1 xref: GO:0004530 xref: MetaCyc:3.1.21.1-RXN is_a: CCO:F0003446 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0000927 name: deoxyribonuclease II activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1] subset: gosubset_prok synonym: "acid deoxyribonuclease activity" EXACT [EC:3.1.22.1] synonym: "acid DNase activity" EXACT [EC:3.1.22.1] synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.22.1] synonym: "DNase II activity" EXACT [EC:3.1.22.1] synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1] synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1] xref: EC:3.1.22.1 xref: GO:0004531 xref: MetaCyc:3.1.22.1-RXN is_a: CCO:F0003447 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0000928 name: exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: GO:0004532 is_a: CCO:F0000923 ! exonuclease activity is_a: CCO:F0000934 ! ribonuclease activity [Term] id: CCO:F0000929 name: exoribonuclease H activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684] synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2] xref: EC:3.1.13.2 xref: GO:0004533 xref: MetaCyc:3.1.13.2-RXN is_a: CCO:F0003454 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0000930 name: 5'-3' exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] xref: EC:3.1.13.- xref: GO:0004534 is_a: CCO:F0001876 ! 5'-3' exonuclease activity is_a: CCO:F0003454 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0000931 name: poly(A)-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] synonym: "2',3'-exoribonuclease activity" EXACT [EC:3.1.13.4] synonym: "3'-exoribonuclease activity" EXACT [EC:3.1.13.4] synonym: "poly(A)-specific RNase activity" EXACT [] xref: EC:3.1.13.4 xref: GO:0004535 xref: MetaCyc:3.1.13.4-RXN is_a: CCO:F0003454 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0000932 name: deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] comment: Consider also annotating to the molecular function term 'DNA binding ; GO:0003677'. subset: gosubset_prok xref: GO:0004536 is_a: CCO:F0000915 ! nuclease activity [Term] id: CCO:F0000933 name: caspase-activated deoxyribonuclease activity namespace: molecular_function xref: GO:0004537 is_a: CCO:F0000932 ! deoxyribonuclease activity [Term] id: CCO:F0000934 name: ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] comment: Consider also annotating to the molecular function term 'RNA binding ; GO:0003723'. subset: gosubset_prok xref: GO:0004540 is_a: CCO:F0000915 ! nuclease activity [Term] id: CCO:F0000935 name: tRNA-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah] subset: gosubset_prok synonym: "tRNA-specific RNase activity" EXACT [] xref: GO:0004549 is_a: CCO:F0000934 ! ribonuclease activity [Term] id: CCO:F0000936 name: nucleoside diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] subset: gosubset_prok synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "NDK activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphate (UDP) kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphokinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside-diphosphate kinase activity" EXACT [] synonym: "nucleotide phosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "UDP kinase activity" EXACT [EC:2.7.4.6] synonym: "uridine diphosphate kinase activity" EXACT [EC:2.7.4.6] xref: EC:2.7.4.6 xref: GO:0004550 xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN xref: Reactome:12403 is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor is_a: CCO:F0004128 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: CCO:F0000937 name: nucleotide diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9] subset: gosubset_prok synonym: "dinucleotide nucleotidohydrolase activity" EXACT [EC:3.6.1.9] synonym: "nucleotide pyrophosphatase activity" EXACT [] synonym: "nucleotide-sugar pyrophosphatase activity" EXACT [EC:3.6.1.9] xref: EC:3.6.1.9 xref: GO:0004551 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0000938 name: octanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + NADH + H+." [EC:1.1.1.73] synonym: "1-octanol dehydrogenase activity" EXACT [EC:1.1.1.73] synonym: "octanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.73] xref: EC:1.1.1.73 xref: GO:0004552 xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000939 name: hydrolase activity, hydrolyzing O-glycosyl compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] subset: gosubset_prok synonym: "O-glucosyl hydrolase activity" EXACT [] xref: EC:3.2.1 xref: GO:0004553 is_a: CCO:F0003368 ! hydrolase activity, acting on glycosyl bonds [Term] id: CCO:F0000940 name: alpha,alpha-trehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28] subset: gosubset_prok synonym: "alpha,alpha-trehalose glucohydrolase activity" EXACT [EC:3.2.1.28] xref: EC:3.2.1.28 xref: GO:0004555 xref: MetaCyc:TREHALA-RXN xref: Reactome:12414 is_a: CCO:F0003022 ! trehalase activity [Term] id: CCO:F0000941 name: alpha-amylase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units." [EC:3.2.1.1] subset: gosubset_prok synonym: "1,4-alpha-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.1] synonym: "alpha amylase activity" EXACT [EC:3.2.1.1] synonym: "endoamylase activity" EXACT [EC:3.2.1.1] synonym: "glycogenase activity" BROAD [EC:3.2.1.1] synonym: "taka-amylase A" RELATED [EC:3.2.1.1] xref: EC:3.2.1.1 xref: GO:0004556 xref: MetaCyc:3.2.1.1-RXN xref: Reactome:12418 is_a: CCO:F0003051 ! amylase activity [Term] id: CCO:F0000942 name: alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22] subset: gosubset_prok synonym: "alpha-D-galactosidase activity" EXACT [EC:3.2.1.22] synonym: "alpha-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22] synonym: "alpha-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "melibiase activity" EXACT [] xref: EC:3.2.1.22 xref: GO:0004557 xref: MetaCyc:ALPHAGALACTOSID-RXN is_a: CCO:F0003020 ! galactosidase activity [Term] id: CCO:F0000943 name: alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20] subset: gosubset_prok synonym: "acid maltase activity" EXACT [EC:3.2.1.20] synonym: "alpha-1,4-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucopyranosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucosidase II" RELATED [] synonym: "alpha-glucoside hydrolase activity" EXACT [EC:3.2.1.20] synonym: "glucoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidosucrase activity" EXACT [EC:3.2.1.20] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20] synonym: "maltase-glucoamylase activity" EXACT [EC:3.2.1.20] xref: EC:3.2.1.20 xref: GO:0004558 xref: GO:0004562 xref: GO:0016982 xref: MetaCyc:3.2.1.20-RXN xref: Reactome:12426 is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0000944 name: alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24] subset: gosubset_prok synonym: "1,2-alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.24] synonym: "alpha-D-mannopyranosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.24] synonym: "exo-alpha-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "p-nitrophenyl-alpha-mannosidase activity" EXACT [EC:3.2.1.24] xref: EC:3.2.1.24 xref: GO:0004559 xref: MetaCyc:3.2.1.24-RXN is_a: CCO:F0003018 ! mannosidase activity [Term] id: CCO:F0000945 name: alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51] subset: gosubset_prok synonym: "alpha-fucosidase activity" EXACT [EC:3.2.1.51] synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51] xref: EC:3.2.1.51 xref: GO:0004560 xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN is_a: CCO:F0003023 ! fucosidase activity [Term] id: CCO:F0000946 name: alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50] synonym: "alpha-acetylglucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-D-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "NAG activity" EXACT [EC:3.2.1.50] xref: EC:3.2.1.50 xref: GO:0004561 xref: MetaCyc:3.2.1.50-RXN is_a: CCO:F0003024 ! hexosaminidase activity [Term] id: CCO:F0000947 name: beta-N-acetylhexosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52] subset: gosubset_prok synonym: "beta-acetylaminodeoxyhexosidase activity" EXACT [EC:3.2.1.52] synonym: "beta-acetylhexosaminidinase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" EXACT [EC:3.2.1.52] synonym: "hexosaminidase A" RELATED [EC:3.2.1.52] synonym: "N-acetyl-beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] xref: EC:3.2.1.52 xref: GO:0004563 xref: MetaCyc:3.2.1.52-RXN is_a: CCO:F0003024 ! hexosaminidase activity [Term] id: CCO:F0000948 name: beta-fructofuranosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides." [EC:3.2.1.26] subset: gosubset_prok synonym: "acid invertase activity" EXACT [] synonym: "alkaline invertase activity" EXACT [] synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT [] synonym: "beta-fructosidase activity" BROAD [] synonym: "beta-h-fructosidase activity" EXACT [] synonym: "fructosylinvertase activity" EXACT [] synonym: "glucosucrase activity" EXACT [] synonym: "invertase activity" BROAD [] synonym: "invertin activity" BROAD [] synonym: "maxinvert L 1000 activity" EXACT [] synonym: "saccharase activity" EXACT [] synonym: "sucrase activity" BROAD [] xref: EC:3.2.1.26 xref: GO:0004564 xref: MetaCyc:3.2.1.26-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0000949 name: beta-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23] comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase. subset: gosubset_prok synonym: "beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "beta-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "exo-(1->4)-beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "hydrolact" RELATED [EC:3.2.1.23] synonym: "lactose hydrolysis" RELATED [] synonym: "lactozym" RELATED [EC:3.2.1.23] synonym: "maxilact" RELATED [EC:3.2.1.23] synonym: "oryzatym" RELATED [EC:3.2.1.23] synonym: "S 2107" RELATED [EC:3.2.1.23] synonym: "sumiklat" RELATED [EC:3.2.1.23] synonym: "trilactase activity" EXACT [EC:3.2.1.23] xref: EC:3.2.1.23 xref: GO:0004565 xref: MetaCyc:3.2.1.23-RXN xref: MetaCyc:BGALACT-PWY is_a: CCO:F0003020 ! galactosidase activity [Term] id: CCO:F0000950 name: beta-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31] subset: gosubset_prok synonym: "beta-D-glucuronoside glucuronosohydrolase activity" EXACT [EC:3.2.1.31] synonym: "beta-glucuronide glucuronohydrolase activity" EXACT [EC:3.2.1.31] synonym: "exo-beta-D-glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "ketodase activity" EXACT [EC:3.2.1.31] xref: EC:3.2.1.31 xref: GO:0004566 xref: MetaCyc:BETA-GLUCURONID-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0000951 name: beta-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25] subset: gosubset_prok synonym: "beta-D-mannosidase activity" EXACT [EC:3.2.1.25] synonym: "beta-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "beta-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "exo-beta-D-mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannase activity" EXACT [EC:3.2.1.25] xref: EC:3.2.1.25 xref: GO:0004567 xref: MetaCyc:3.2.1.25-RXN is_a: CCO:F0003018 ! mannosidase activity [Term] id: CCO:F0000952 name: chitinase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins." [EC:3.2.1.14] subset: gosubset_prok synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" EXACT [EC:3.2.1.14] synonym: "chitodextrinase activity" EXACT [EC:3.2.1.14] synonym: "poly-beta-glucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" EXACT [EC:3.2.1.14] xref: EC:3.2.1.14 xref: GO:0004568 xref: MetaCyc:3.2.1.14-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0000953 name: glycoprotein endo-alpha-1,2-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130] synonym: "endo-alpha-mannosidase activity" EXACT [EC:3.2.1.130] synonym: "endomannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosyl mannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosylmannosidase activity" EXACT [EC:3.2.1.130] synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130] xref: EC:3.2.1.130 xref: GO:0004569 xref: MetaCyc:3.2.1.130-RXN is_a: CCO:F0000944 ! alpha-mannosidase activity [Term] id: CCO:F0000954 name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113] subset: gosubset_prok synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.113] synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.113] synonym: "exo-alpha-1,2-mannanase activity" EXACT [EC:3.2.1.113] synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113] synonym: "man9-mannosidase activity" RELATED [EC:3.2.1.113] synonym: "Man9-mannosidase activity" EXACT [EC:3.2.1.113] synonym: "ManI activity" NARROW [EC:3.2.1.113] synonym: "mannose-9 processing alpha-mannosidase activity" EXACT [EC:3.2.1.113] synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113] synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113] synonym: "mannosidase I" RELATED [EC:3.2.1.113] xref: EC:3.2.1.113 xref: GO:0004571 xref: MetaCyc:3.2.1.113-RXN is_a: CCO:F0003019 ! mannosyl-oligosaccharide mannosidase activity [Term] id: CCO:F0000955 name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal 1,3- and 1,6-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114] synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.114] synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114] synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "alpha1-3,6-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "exo-1,3-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" EXACT [EC:3.2.1.114] synonym: "golgi alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "ManII activity" NARROW [EC:3.2.1.114] synonym: "mannosidase II activity" NARROW [EC:3.2.1.114] xref: EC:3.2.1.114 xref: GO:0004572 xref: MetaCyc:3.2.1.114-RXN is_a: CCO:F0003019 ! mannosyl-oligosaccharide mannosidase activity [Term] id: CCO:F0000956 name: mannosyl-oligosaccharide glucosidase activity namespace: molecular_function def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106] synonym: "Glc3Man9NAc2 oligosaccharide glucosidase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucohydrolase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT [] synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106] synonym: "trimming glucosidase I" RELATED [EC:3.2.1.106] xref: EC:3.2.1.106 xref: GO:0004573 xref: MetaCyc:3.2.1.106-RXN is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0000957 name: oligo-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose." [EC:3.2.1.10] subset: gosubset_prok synonym: "alpha-limit dextrinase activity" EXACT [EC:3.2.1.10] synonym: "dextrin 6-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "dextrin 6alpha-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "exo-oligo-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "isomaltase activity" RELATED [EC:3.2.1.10] synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10] xref: EC:3.2.1.10 xref: GO:0004574 xref: MetaCyc:3.2.1.10-RXN is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0000958 name: sucrose alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action." [EC:3.2.1.48] synonym: "intestinal sucrase activity" EXACT [EC:3.2.1.48] synonym: "sucrase activity" EXACT [EC:3.2.1.48] synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48] synonym: "sucrase-isomaltase activity" EXACT [EC:3.2.1.48] synonym: "sucrose alpha-D-glucohydrolase activity" EXACT [] synonym: "sucrose alpha-glucohydrolase activity" EXACT [EC:3.2.1.48] synonym: "sucrose-alpha-D-glucohydrolase activity" EXACT [EC:3.2.1.48] synonym: "sucrose.alpha.-glucohydrolase activity" EXACT [EC:3.2.1.48] xref: EC:3.2.1.48 xref: GO:0004575 xref: MetaCyc:3.2.1.48-RXN xref: Reactome:12493 is_a: CCO:F0000943 ! alpha-glucosidase activity [Term] id: CCO:F0000959 name: oligosaccharyl transferase activity namespace: molecular_function def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok xref: EC:2.4.1.- xref: GO:0004576 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0000960 name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141] synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.4.1.141] synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.141] synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.141] synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.141] xref: EC:2.4.1.141 xref: GO:0004577 xref: MetaCyc:2.4.1.141-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0000961 name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142] synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] xref: EC:2.4.1.142 xref: GO:0004578 xref: MetaCyc:2.4.1.142-RXN is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0000962 name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119] synonym: "asparagine N-glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT [] synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "oligomannosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "oligosaccharide transferase activity" EXACT [EC:2.4.1.119] xref: EC:2.4.1.119 xref: GO:0004579 xref: MetaCyc:2.4.1.119-RXN is_a: CCO:F0000959 ! oligosaccharyl transferase activity [Term] id: CCO:F0000963 name: dolichyl-phosphate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117] subset: gosubset_prok synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" EXACT [EC:2.4.1.117] xref: EC:2.4.1.117 xref: GO:0004581 xref: MetaCyc:2.4.1.117-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0000964 name: dolichyl-phosphate beta-D-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83] subset: gosubset_prok synonym: "dolichol phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate-mannose synthase activity" EXACT [] synonym: "dolichyl mannosyl phosphate synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phospho-mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "DPM synthase activity" EXACT [] synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPMan:DolP mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphodolichol synthase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphoryldolichol synthase activity" EXACT [EC:2.4.1.83] xref: EC:2.4.1.83 xref: GO:0004582 xref: MetaCyc:2.4.1.83-RXN xref: Reactome:12521 is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0000965 name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity namespace: molecular_function xref: EC:2.4.1.- xref: GO:0004583 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0000966 name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130] synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "oligomannosylsynthase activity" EXACT [EC:2.4.1.130] xref: EC:2.4.1.130 xref: GO:0004584 xref: MetaCyc:2.4.1.130-RXN is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0000967 name: ornithine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3] subset: gosubset_prok synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "carbamylphosphate-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "citrulline phosphorylase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "OTC activity" EXACT [EC:2.1.3.3] synonym: "OTCase activity" EXACT [EC:2.1.3.3] xref: EC:2.1.3.3 xref: GO:0004585 xref: MetaCyc:ORNCARBAMTRANSFER-RXN xref: Reactome:12530 is_a: CCO:F0003319 ! carboxyl- or carbamoyltransferase activity [Term] id: CCO:F0000968 name: ornithine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = putrescine + CO2." [EC:4.1.1.17] subset: gosubset_prok synonym: "L-ornithine carboxy-lyase (putrescine-forming)" EXACT [EC:4.1.1.17] synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17] synonym: "SpeC" RELATED [EC:4.1.1.17] xref: EC:4.1.1.17 xref: GO:0004586 xref: MetaCyc:ORNDECARBOX-RXN xref: Reactome:12531 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000969 name: ornithine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13] subset: gosubset_prok synonym: "GabT" RELATED [EC:2.6.1.13] synonym: "L-ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "OAT" RELATED [EC:2.6.1.13] synonym: "ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine delta-transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine ketoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--2-oxoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo-acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine-oxo-acid aminotransferase activity" EXACT [] synonym: "ornithine:alpha-oxoglutarate transaminase activity" EXACT [EC:2.6.1.13] xref: EC:2.6.1.13 xref: GO:0004587 xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN xref: Reactome:12532 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0000970 name: orotate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10] subset: gosubset_prok synonym: "OPRT activity" EXACT [EC:2.4.2.10] synonym: "OPRTase activity" EXACT [EC:2.4.2.10] synonym: "orotate phosphoribosyl pyrophosphate transferase activity" EXACT [EC:2.4.2.10] synonym: "orotic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate diphosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic pyrophosphorylase activity" EXACT [EC:2.4.2.10] xref: EC:2.4.2.10 xref: GO:0004588 xref: MetaCyc:OROPRIBTRANS-RXN xref: Reactome:12534 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0000971 name: orotate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + NAD+ = orotate + NADH + H+." [EC:1.3.1.14] synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.14] xref: EC:1.3.1.14 xref: GO:0004589 xref: MetaCyc:OROTATE-REDUCTASE-(NADH)-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000972 name: orotidine-5'-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2." [EC:4.1.1.23] subset: gosubset_prok synonym: "ODCase activity" EXACT [EC:4.1.1.23] synonym: "OMP decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "OMP-DC" RELATED [EC:4.1.1.23] synonym: "OMPdcase activity" EXACT [EC:4.1.1.23] synonym: "orotate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotate monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine 5'-phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic acid decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotodylate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "UMP synthase activity" EXACT [EC:4.1.1.23] synonym: "uridine 5'-monophosphate synthase activity" EXACT [EC:4.1.1.23] xref: EC:4.1.1.23 xref: GO:0004590 xref: MetaCyc:OROTPDECARB-RXN xref: Reactome:12548 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000973 name: oxoglutarate dehydrogenase (succinyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2] subset: gosubset_prok synonym: "2-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate: lipoate oxidoreductase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" EXACT [EC:1.2.4.2] synonym: "AKGDH activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric acid dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "OGDC activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate decarboxylase activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT [] synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] xref: EC:1.2.4.2 xref: GO:0004591 xref: MetaCyc:RXN0-1146 is_a: CCO:F0003226 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: CCO:F0000974 name: pantoate-beta-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1] subset: gosubset_prok synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantothenate synthetase activity" EXACT [EC:6.3.2.1] xref: EC:6.3.2.1 xref: GO:0004592 xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0000975 name: pantothenase activity namespace: molecular_function def: "Catalysis of the reaction: pantothenate + H2O = pantoate + beta-alanine." [EC:3.5.1.22] synonym: "(R)-pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate hydrolase activity" EXACT [EC:3.5.1.22] xref: EC:3.5.1.22 xref: GO:0004593 xref: MetaCyc:PANTOTHENASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0000976 name: pantothenate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33] subset: gosubset_prok synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "ATP:pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "D-pantothenate kinase activity" EXACT [EC:2.7.1.33] synonym: "pantothenate kinase (phosphorylating) activity" EXACT [EC:2.7.1.33] synonym: "pantothenic acid kinase activity" EXACT [EC:2.7.1.33] xref: EC:2.7.1.33 xref: GO:0004594 xref: MetaCyc:PANTOTHENATE-KIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0000977 name: pantetheine-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = diphosphate + dephospho-CoA." [EC:2.7.7.3] subset: gosubset_prok synonym: "3'-dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT [] synonym: "dephospho-CoA diphosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-coenzyme A pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "pantetheine phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "phosphopantetheine adenylyltransferase activity" EXACT [] synonym: "PPAT activity" EXACT [EC:2.7.7.3] xref: EC:2.7.7.3 xref: GO:0004595 xref: MetaCyc:PANTEPADENYLYLTRAN-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000978 name: peptide alpha-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of the N-terminal amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide." [EC:2.3.1.88, GOC:mah] subset: gosubset_prok synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [EC:2.3.1.88] synonym: "beta-endorphin acetyltransferase activity" NARROW [EC:2.3.1.88] synonym: "N(alpha)-acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "NAT activity" RELATED [EC:2.3.1.88] synonym: "peptide acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "protein N-terminal acetyltransferase activity" EXACT [EC:2.3.1.88] xref: EC:2.3.1.88 xref: GO:0004596 xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0005533 ! peptide N-acetyltransferase activity [Term] id: CCO:F0000979 name: peptide-aspartate beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16] subset: gosubset_prok synonym: "aspartate beta-hydroxylase activity" EXACT [EC:1.14.11.16] synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16] synonym: "aspartylpeptide beta-dioxygenase activity" EXACT [EC:1.14.11.16] synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.16] xref: EC:1.14.11.16 xref: GO:0004597 xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0000980 name: peptidylamidoglycolate lyase activity namespace: molecular_function def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5] synonym: "alpha-hydroxyglycine amidating dealkylase activity" EXACT [EC:4.3.2.5] synonym: "HGAD" RELATED [EC:4.3.2.5] synonym: "PAL" RELATED [EC:4.3.2.5] synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5] synonym: "PGL" RELATED [EC:4.3.2.5] xref: EC:4.3.2.5 xref: GO:0004598 xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN is_a: CCO:F0003407 ! amidine-lyase activity [Term] id: CCO:F0000981 name: peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O." [EC:1.11.1.7] subset: gosubset_prok synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7] synonym: "eosinophil peroxidase activity" NARROW [] synonym: "extensin peroxidase" NARROW [EC:1.11.1.7] synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7] synonym: "heme peroxidase" NARROW [EC:1.11.1.7] synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7] synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7] synonym: "lactoperoxidase activity" NARROW [] synonym: "MPO" RELATED [EC:1.11.1.7] synonym: "myeloperoxidase activity" NARROW [] synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7] synonym: "peroxidase reaction" EXACT [] synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7] synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7] synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7] synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7] synonym: "verdoperoxidase" NARROW [EC:1.11.1.7] xref: EC:1.11.1.7 xref: GO:0004601 xref: GO:0016685 xref: GO:0016686 xref: GO:0016687 xref: MetaCyc:PEROXID-RXN xref: Reactome:4411 is_a: CCO:F0003069 ! antioxidant activity is_a: CCO:F0003274 ! oxidoreductase activity, acting on peroxide as acceptor [Term] id: CCO:F0000982 name: glutathione peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O." [EC:1.11.1.9] subset: gosubset_prok synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.9] synonym: "GSH peroxidase activity" EXACT [EC:1.11.1.9] synonym: "non-selenium glutathione peroxidase activity" NARROW [] synonym: "reduced glutathione peroxidase activity" EXACT [EC:1.11.1.9] synonym: "selenium-glutathione peroxidase activity" EXACT [EC:1.11.1.9] xref: EC:1.11.1.9 xref: GO:0004602 xref: GO:0016224 xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN xref: Reactome:13237 is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0000983 name: phenylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28] synonym: "noradrenalin N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28] synonym: "norepinephrine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "norepinephrine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] xref: EC:2.1.1.28 xref: GO:0004603 xref: MetaCyc:2.1.1.28-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0000984 name: phosphoadenylyl-sulfate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8] subset: gosubset_prok synonym: "3'-phosphoadenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "PAdoPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase, thioredoxin-dependent activity" EXACT [EC:1.8.4.8] synonym: "PAPS sulfotransferase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenosine-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT [] synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] xref: EC:1.8.4.8 xref: GO:0004604 xref: MetaCyc:1.8.4.8-RXN is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0000985 name: phosphatidate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41] subset: gosubset_prok synonym: "CDP diglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "CDP-DG" RELATED [EC:2.7.7.41] synonym: "CDP-diacylglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CDP-diacylglycerol synthase activity" EXACT [] synonym: "CDP-diglyceride diphosphorylase activity" EXACT [] synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT [] synonym: "CDP-diglyceride synthase activity" EXACT [] synonym: "CDP-diglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP-diacylglycerol synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" EXACT [EC:2.7.7.41] synonym: "CTP:phosphatidate cytidylyltransferase activity" EXACT [EC:2.7.7.41] synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "DAG synthetase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidate cytidyltransferase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidic acid cytidylyltransferase activity" EXACT [EC:2.7.7.41] xref: EC:2.7.7.41 xref: GO:0004605 xref: MetaCyc:CDPDIGLYSYN-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0000986 name: phosphatidylcholine-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43] subset: gosubset_prok synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43] synonym: "LCAT activity" EXACT [EC:2.3.1.43] synonym: "lecithin--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "lecithin:cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phosphatidylcholine:sterol O-acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] xref: EC:2.3.1.43 xref: GO:0004607 xref: MetaCyc:2.3.1.43-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0000987 name: phosphatidylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17] subset: gosubset_prok synonym: "lipid methyl transferase activity" EXACT [EC:2.1.1.17] synonym: "LMTase activity" EXACT [EC:2.1.1.17] synonym: "PEMT" RELATED [EC:2.1.1.17] synonym: "phosphatidylethanolamine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-N-methylase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.17] xref: EC:2.1.1.17 xref: GO:0004608 xref: MetaCyc:2.1.1.17-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0000988 name: phosphatidylserine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidyl-L-serine = phosphatidylethanolamine + CO2." [EC:4.1.1.65] subset: gosubset_prok synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" EXACT [EC:4.1.1.65] synonym: "phosphatidyl-L-serine carboxy-lyase activity" EXACT [EC:4.1.1.65] synonym: "PS decarboxylase activity" EXACT [EC:4.1.1.65] xref: EC:4.1.1.65 xref: GO:0004609 xref: MetaCyc:PHOSPHASERDECARB-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000989 name: phosphoacetylglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3] subset: gosubset_prok synonym: "acetylaminodeoxyglucose phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "acetylglucosamine phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetylglucosamine-phosphate mutase activity" EXACT [EC:5.4.2.3] synonym: "phospho-N-acetylglucosamine mutase activity" EXACT [EC:5.4.2.3] xref: EC:5.4.2.3 xref: GO:0004610 xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0000990 name: phosphoenolpyruvate carboxykinase activity namespace: molecular_function def: "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2." [EC:4.1.1.-] subset: gosubset_prok synonym: "PEP carboxykinase activity" EXACT [EC:4.1.1.-] synonym: "PEPCK activity" EXACT [EC:4.1.1.-] synonym: "phosphopyruvate carboxylase activity" EXACT [EC:4.1.1.-] xref: EC:4.1.1.- xref: GO:0004611 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0000991 name: phosphoenolpyruvate carboxykinase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2." [EC:4.1.1.49] subset: gosubset_prok synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.49] synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.49] synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49] synonym: "PEPK" RELATED [EC:4.1.1.49] synonym: "phosphoenolpyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" EXACT [EC:4.1.1.49] synonym: "phosphopyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] xref: EC:4.1.1.49 xref: GO:0004612 xref: MetaCyc:PEPCARBOXYKIN-RXN is_a: CCO:F0000990 ! phosphoenolpyruvate carboxykinase activity [Term] id: CCO:F0000992 name: phosphoenolpyruvate carboxykinase (GTP) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32] subset: gosubset_prok synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.32] synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT [] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxykinase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxylase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate carboxylase (GTP)" EXACT [EC:4.1.1.32] xref: EC:4.1.1.32 xref: GO:0004613 xref: MetaCyc:4.1.1.32-RXN xref: Reactome:13265 is_a: CCO:F0000990 ! phosphoenolpyruvate carboxykinase activity [Term] id: CCO:F0000993 name: phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2] subset: gosubset_prok synonym: "alpha-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "glucose phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "phosphoglucose mutase activity" EXACT [EC:5.4.2.2] xref: EC:5.4.2.2 xref: GO:0004614 xref: MetaCyc:PHOSPHOGLUCMUT-RXN xref: Reactome:13266 is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0000994 name: phosphomannomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8] subset: gosubset_prok synonym: "alpha-D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "mannose phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "phosphomannose mutase activity" EXACT [EC:5.4.2.8] xref: EC:5.4.2.8 xref: GO:0004615 xref: GO:0008971 xref: MetaCyc:PHOSMANMUT-RXN is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0000995 name: phosphogluconate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] subset: gosubset_prok synonym: "6-phospho-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.44] synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic carboxylase activity" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44] synonym: "6PGD activity" EXACT [EC:1.1.1.44] synonym: "phosphogluconic acid dehydrogenase activity" EXACT [EC:1.1.1.44] xref: EC:1.1.1.44 xref: GO:0004616 xref: MetaCyc:6PGLUCONDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000996 name: phosphoglycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] subset: gosubset_prok synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3PHP reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-KG reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "alphaKG reductase activity" EXACT [EC:1.1.1.95] synonym: "D- and L-HGA" RELATED [EC:1.1.1.95] synonym: "D-3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "glycerate 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "glycerate-1,3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "PGDH activity" EXACT [EC:1.1.1.95] synonym: "phosphoglycerate oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "SerA" RELATED [EC:1.1.1.95] synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95] xref: EC:1.1.1.95 xref: GO:0004617 xref: MetaCyc:PGLYCDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0000997 name: phosphoglycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate." [EC:2.7.2.3] subset: gosubset_prok synonym: "3-PGK" RELATED [EC:2.7.2.3] synonym: "3-phosphoglycerate kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglycerate phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "glycerate 3-phosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "glycerophosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "PGK" RELATED [EC:2.7.2.3] synonym: "phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglycerokinase activity" EXACT [EC:2.7.2.3] xref: EC:2.7.2.3 xref: GO:0004618 xref: MetaCyc:PHOSGLYPHOS-RXN xref: Reactome:13282 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0000998 name: phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] subset: gosubset_prok synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1] synonym: "D-phosphoglycerate 2,3-phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1] synonym: "GriP mutase" NARROW [EC:5.4.2.1] synonym: "monophosphoglycerate mutase activity" EXACT [EC:5.4.2.1] synonym: "monophosphoglyceromutase activity" EXACT [EC:5.4.2.1] synonym: "MPGM" RELATED [EC:5.4.2.1] synonym: "PGA mutase activity" EXACT [EC:5.4.2.1] synonym: "PGAM activity" EXACT [EC:5.4.2.1] synonym: "PGM" EXACT [] synonym: "phosphoglycerate phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "phosphoglyceromutase activity" EXACT [EC:5.4.2.1] xref: EC:5.4.2.1 xref: GO:0004619 xref: MetaCyc:3PGAREARR-RXN xref: Reactome:13285 is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0000999 name: phospholipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.1.1.- xref: GO:0004620 is_a: CCO:F0003111 ! lipase activity [Term] id: CCO:F0001000 name: glycosylphosphatidylinositol phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50] synonym: "glycoprotein phospholipase D activity" EXACT [] synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" EXACT [EC:3.1.4.50] synonym: "GPI-PLD activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-specific phospholipase D activity" EXACT [EC:3.1.4.50] xref: EC:3.1.4.50 xref: GO:0004621 xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN is_a: CCO:F0001004 ! phospholipase D activity [Term] id: CCO:F0001001 name: lysophospholipase activity namespace: molecular_function def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] subset: gosubset_prok synonym: "2-lysophosphatidylcholine acylhydrolase activity" EXACT [EC:3.1.1.5] synonym: "lecithinase B activity" EXACT [EC:3.1.1.5] synonym: "lecitholipase activity" EXACT [EC:3.1.1.5] synonym: "lysolecithinase activity" EXACT [EC:3.1.1.5] synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5] synonym: "lysophosphatidase activity" EXACT [EC:3.1.1.5] synonym: "lysophosphatidylcholine hydrolase activity" EXACT [EC:3.1.1.5] synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5] synonym: "phosphatidase B" RELATED [EC:3.1.1.5] synonym: "phospholipase B activity" EXACT [EC:3.1.1.5] xref: EC:3.1.1.5 xref: GO:0004622 xref: GO:0045126 xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0000999 ! phospholipase activity [Term] id: CCO:F0001002 name: phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] subset: gosubset_prok synonym: "cytosolic phospholipase A2 activity" NARROW [] synonym: "lecithinase A activity" EXACT [EC:3.1.1.4] synonym: "phosphatidase activity" RELATED [EC:3.1.1.4] synonym: "phosphatidolipase activity" EXACT [EC:3.1.1.4] synonym: "phosphatidylcholine 2-acylhydrolase activity" EXACT [EC:3.1.1.4] synonym: "phospholipase A" RELATED [EC:3.1.1.4] synonym: "secreted phospholipase A2 activity" NARROW [] xref: EC:3.1.1.4 xref: GO:0004623 xref: MetaCyc:PHOSPHOLIPASE-A2-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0000999 ! phospholipase activity [Term] id: CCO:F0001003 name: phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate." [EC:3.1.4.3, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alpha-toxin" NARROW [EC:3.1.4.3] synonym: "Clostridium oedematiens beta- and gamma-toxins activity" NARROW [EC:3.1.4.3] synonym: "Clostridium welchii alpha-toxin activity" NARROW [EC:3.1.4.3] synonym: "heat-labile hemolysin" NARROW [EC:3.1.4.3] synonym: "lecithinase C activity" EXACT [EC:3.1.4.3] synonym: "lipophosphodiesterase C" RELATED [EC:3.1.4.3] synonym: "lipophosphodiesterase I activity" EXACT [EC:3.1.4.3] synonym: "phosphatidase C" RELATED [EC:3.1.4.3] synonym: "phosphatidylcholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.3] synonym: "phospholipase C, acting on phosphatidylcholine" NARROW [] xref: EC:3.1.4.3 xref: GO:0004629 xref: GO:0042298 xref: MetaCyc:PHOSPHOLIPASE-C-RXN xref: Reactome:11457 is_a: CCO:F0000999 ! phospholipase activity is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0001004 name: phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4] subset: gosubset_prok synonym: "choline phosphatase activity" EXACT [EC:3.1.4.4] synonym: "lecithinase D activity" EXACT [EC:3.1.4.4] synonym: "lipophosphodiesterase II activity" EXACT [EC:3.1.4.4] synonym: "phosphatidylcholine phosphatidohydrolase activity" EXACT [EC:3.1.4.4] xref: EC:3.1.4.4 xref: GO:0004630 xref: MetaCyc:PHOSPHOLIPASE-D-RXN is_a: CCO:F0000999 ! phospholipase activity is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0001005 name: phosphomevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate." [EC:2.7.4.2] subset: gosubset_prok synonym: "5-phosphomevalonate kinase activity" EXACT [EC:2.7.4.2] synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "ATP:5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate-5-phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonic acid phosphate kinase activity" EXACT [EC:2.7.4.2] xref: EC:2.7.4.2 xref: GO:0004631 xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN xref: Reactome:13380 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0001006 name: phosphopantothenate--cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5] subset: gosubset_prok synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" EXACT [EC:6.3.2.5] synonym: "phosphopantothenate-cysteine ligase activity" EXACT [] synonym: "phosphopantothenoylcysteine synthetase activity" EXACT [] xref: EC:6.3.2.5 xref: GO:0004632 xref: MetaCyc:P-PANTOCYSLIG-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0001007 name: phosphopantothenoylcysteine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-((R)-4-phosphopantothenoyl)-L-cysteine = pantetheine 4'-phosphate + CO2." [EC:4.1.1.36] subset: gosubset_prok synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "4-phosphopantotheoylcysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "PPC-decarboxylase activity" EXACT [EC:4.1.1.36] xref: EC:4.1.1.36 xref: GO:0004633 xref: MetaCyc:P-PANTOCYSDECARB-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0001008 name: phosphopyruvate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "14-3-2-protein" RELATED [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase activity" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT [] synonym: "2-phosphoglycerate dehydratase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglycerate enolase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglyceric dehydratase activity" EXACT [EC:4.2.1.11] synonym: "enolase activity" EXACT [EC:4.2.1.11] synonym: "gamma-enolase activity" EXACT [EC:4.2.1.11] synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11] synonym: "phosphoenolpyruvate hydratase activity" EXACT [EC:4.2.1.11] xref: EC:4.2.1.11 xref: GO:0004634 xref: MetaCyc:2PGADEHYDRAT-RXN xref: Reactome:13384 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0001009 name: phosphoribosyl-AMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide." [EC:3.5.4.19] subset: gosubset_prok synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" EXACT [EC:3.5.4.19] synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" EXACT [EC:3.5.4.19] synonym: "PRAMP-cyclohydrolase activity" EXACT [EC:3.5.4.19] xref: EC:3.5.4.19 xref: GO:0004635 xref: MetaCyc:HISTCYCLOHYD-RXN is_a: CCO:F0004139 ! cyclohydrolase activity [Term] id: CCO:F0001010 name: phosphoribosyl-ATP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + diphosphate." [EC:3.6.1.31] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" EXACT [EC:3.6.1.31] synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT [] synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.31] xref: EC:3.6.1.31 xref: GO:0004636 xref: MetaCyc:HISTPRATPHYD-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0001011 name: phosphoribosylamine-glycine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide." [EC:6.3.4.13] subset: gosubset_prok synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" EXACT [EC:6.3.4.13] synonym: "5'-phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" EXACT [EC:6.3.4.13] synonym: "GAR" RELATED [EC:6.3.4.13] synonym: "GAR synthetase activity" EXACT [EC:6.3.4.13] synonym: "GARS activity" EXACT [EC:6.3.4.13] synonym: "glycinamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "glycineamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycineamide synthetase activity" EXACT [EC:6.3.4.13] xref: EC:6.3.4.13 xref: GO:0004637 xref: MetaCyc:GLYRIBONUCSYN-RXN xref: Reactome:13392 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0001012 name: phosphoribosylaminoimidazole carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2." [EC:4.1.1.21] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" EXACT [EC:4.1.1.21] synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" EXACT [EC:4.1.1.21] synonym: "ADE2" RELATED [EC:4.1.1.21] synonym: "AIR carboxylase activity" EXACT [EC:4.1.1.21] synonym: "class II PurE" RELATED [EC:4.1.1.21] xref: EC:4.1.1.21 xref: GO:0004638 xref: MetaCyc:AIRCARBOXY-RXN xref: Reactome:13396 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0001013 name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate." [EC:6.3.2.6] subset: gosubset_prok synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" EXACT [EC:6.3.2.6] synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "PurC" RELATED [EC:6.3.2.6] synonym: "SAICAR synthase activity" EXACT [EC:6.3.2.6] synonym: "SAICAR synthetase activity" EXACT [EC:6.3.2.6] synonym: "SAICARs activity" EXACT [EC:6.3.2.6] xref: EC:6.3.2.6 xref: GO:0004639 xref: MetaCyc:SAICARSYN-RXN xref: Reactome:13398 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0001014 name: phosphoribosylanthranilate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)-anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24] subset: gosubset_prok synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24] synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRA isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRAI activity" EXACT [EC:5.3.1.24] xref: EC:5.3.1.24 xref: GO:0004640 xref: MetaCyc:PRAISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0001015 name: phosphoribosylformylglycinamidine cyclo-ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole." [EC:6.3.3.1] subset: gosubset_prok synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "5'-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIRS activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosyl-aminoimidazole synthetase activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosylaminoimidazole synthetase activity" EXACT [EC:6.3.3.1] xref: EC:6.3.3.1 xref: GO:0004641 xref: MetaCyc:AIRS-RXN xref: Reactome:13434 is_a: CCO:F0003441 ! cyclo-ligase activity [Term] id: CCO:F0001016 name: phosphoribosylformylglycinamidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate." [EC:6.3.5.3] subset: gosubset_prok synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "FGAM synthase activity" EXACT [EC:6.3.5.3] synonym: "FGAM synthetase activity" EXACT [EC:6.3.5.3] synonym: "FGAR amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "FGARAT activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribonucloetide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribotide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycinamidine synthetase activity" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycineamidine synthetase activity" EXACT [EC:6.3.5.3] xref: EC:6.3.5.3 xref: GO:0004642 xref: MetaCyc:FGAMSYN-RXN xref: Reactome:13437 is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0001017 name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "AICAR formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "AICAR transformylase activity" EXACT [EC:2.1.2.3] synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] xref: EC:2.1.2.3 xref: GO:0004643 xref: MetaCyc:AICARTRANSFORM-RXN xref: Reactome:13439 is_a: CCO:F0003318 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: CCO:F0001018 name: phosphoribosylglycinamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.2] synonym: "5'-phosphoribosylglycinamide transformylase activity" EXACT [EC:2.1.2.2] synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] synonym: "GAR formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "GAR TFase activity" EXACT [EC:2.1.2.2] synonym: "GAR transformylase activity" EXACT [EC:2.1.2.2] synonym: "GART activity" EXACT [EC:2.1.2.2] synonym: "glycinamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] xref: EC:2.1.2.2 xref: GO:0004644 xref: MetaCyc:GART-RXN xref: Reactome:13440 is_a: CCO:F0003318 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: CCO:F0001019 name: phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.1] synonym: "1,4-alpha-glucan phosphorylase activity" EXACT [EC:2.4.1.1] synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1] synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1] synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1] synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1] synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1] synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1] synonym: "myophosphorylase" NARROW [EC:2.4.1.1] synonym: "polyphosphorylase activity" EXACT [EC:2.4.1.1] synonym: "potato phosphorylase" NARROW [EC:2.4.1.1] synonym: "starch phosphorylase" NARROW [EC:2.4.1.1] xref: EC:2.4.1.1 xref: GO:0004645 xref: MetaCyc:RXN-1826 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0001020 name: phosphoserine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3] subset: gosubset_prok synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3] xref: EC:3.1.3.3 xref: GO:0004647 xref: MetaCyc:PSERPHOSPHA-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0001021 name: phosphoserine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] subset: gosubset_prok synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3PHP transaminase activity" EXACT [EC:2.6.1.52] synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "L-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "PdxC" RELATED [EC:2.6.1.52] synonym: "phosphohydroxypyruvate transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphohydroxypyruvic--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphoserine aminotransferase activity" EXACT [] synonym: "PSAT activity" EXACT [EC:2.6.1.52] synonym: "SerC" RELATED [EC:2.6.1.52] xref: EC:2.6.1.52 xref: GO:0004646 xref: GO:0004648 xref: MetaCyc:PSERTRANSAM-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0001022 name: poly(ADP-ribose) glycohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143] xref: EC:3.2.1.143 xref: GO:0004649 xref: MetaCyc:3.2.1.143-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0001023 name: polygalacturonase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15] subset: gosubset_prok synonym: "endo-D-galacturonase activity" EXACT [] synonym: "endo-polygalacturonase activity" EXACT [] synonym: "endogalacturonase activity" EXACT [] synonym: "endopolygalacturonase activity" EXACT [] synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15] synonym: "pectin hydrolase activity" EXACT [EC:3.2.1.15] synonym: "pectin polygalacturonase activity" EXACT [EC:3.2.1.15] synonym: "pectinase activity" NARROW [EC:3.2.1.15] synonym: "pectolase activity" EXACT [EC:3.2.1.15] synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT [] synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT [] xref: EC:3.2.1.15 xref: GO:0004650 xref: MetaCyc:3.2.1.15-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0001024 name: polynucleotide 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] synonym: "5'-polynucleotidase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-phosphohydrolase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33] xref: EC:3.1.3.33 xref: GO:0004651 xref: MetaCyc:POLYNUCLEOTIDE-5 xref: Reactome:13463 is_a: CCO:F0004127 ! nucleotide phosphatase activity [Term] id: CCO:F0001025 name: polynucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19] subset: gosubset_prok synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "AMP polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP-polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "NTP polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) hydrolase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) synthetase activity" EXACT [EC:2.7.7.19] synonym: "poly-A polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate nucleotidyltransferase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate synthetase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic acid polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic polymerase activity" EXACT [EC:2.7.7.19] synonym: "RNA adenylating enzyme activity" EXACT [EC:2.7.7.19] synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19] synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19] xref: EC:2.7.7.19 xref: GO:0004652 xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN xref: Reactome:72182 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0001026 name: polypeptide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] synonym: "glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "polypeptide-N-acetylgalactosamine transferase activity" EXACT [EC:2.4.1.41] synonym: "protein-UDP acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] xref: EC:2.4.1.41 xref: GO:0004653 xref: MetaCyc:2.4.1.41-RXN is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0001027 name: polyribonucleotide nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8] subset: gosubset_prok synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" EXACT [EC:2.7.7.8] synonym: "polynucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8] xref: EC:2.7.7.8 xref: GO:0004654 xref: MetaCyc:2.7.7.8-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0001028 name: porphobilinogen synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O." [EC:4.2.1.24] subset: gosubset_prok synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" EXACT [EC:4.2.1.24] synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" EXACT [EC:4.2.1.24] synonym: "5-levulinic acid dehydratase activity" EXACT [EC:4.2.1.24] synonym: "aminolevulinate dehydratase activity" EXACT [] synonym: "aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinate dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydrase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydratase activity" EXACT [] synonym: "delta-aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] xref: EC:4.2.1.24 xref: GO:0004655 xref: MetaCyc:PORPHOBILSYNTH-RXN xref: Reactome:13469 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0001029 name: procollagen-proline 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2] synonym: "collagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "hydroxylase, collagen proline activity" EXACT [EC:1.14.11.2] synonym: "peptidyl proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" EXACT [EC:1.14.11.2] synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT [] synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "proline protocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "proline, 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2] synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" EXACT [EC:1.14.11.2] synonym: "prolylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "prolylprotocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "protocollagen proline 4-hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen prolyl hydroxylase activity" EXACT [EC:1.14.11.2] xref: EC:1.14.11.2 xref: GO:0004656 xref: MetaCyc:1.14.11.2-RXN is_a: CCO:F0004175 ! procollagen-proline dioxygenase activity is_a: CCO:F0004684 ! peptidyl-proline 4-dioxygenase activity [Term] id: CCO:F0001030 name: proline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] subset: gosubset_prok synonym: "L-proline dehydrogenase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:acceptor oxidoreductase activity" EXACT [EC:1.5.99.8] xref: EC:1.5.99.8 xref: GO:0004657 xref: MetaCyc:RXN-7181 xref: Reactome:13472 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0001031 name: propionyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3] subset: gosubset_prok synonym: "PCCase activity" EXACT [EC:6.4.1.3] synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.3] synonym: "propionyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.3] xref: EC:6.4.1.3 xref: GO:0004658 xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN xref: Reactome:13473 is_a: CCO:F0003144 ! CoA carboxylase activity [Term] id: CCO:F0001032 name: prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah] subset: gosubset_prok xref: EC:2.5.1.- xref: GO:0004659 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0001033 name: protein farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375] synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" EXACT [EC:2.5.1.58] synonym: "FTase activity" EXACT [EC:2.5.1.58] synonym: "protein-cysteine farnesyltransferase activity" EXACT [] xref: EC:2.5.1.58 xref: GO:0004660 xref: GO:0018223 is_a: CCO:F0001830 ! protein prenyltransferase activity [Term] id: CCO:F0001034 name: protein geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375] synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT [] xref: EC:2.5.1.- xref: GO:0004661 xref: GO:0018224 is_a: CCO:F0001830 ! protein prenyltransferase activity [Term] id: CCO:F0001035 name: CAAX-protein geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375] synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "geranylgeranyltransferase type I activity" EXACT [] synonym: "GGTase-I activity" EXACT [] synonym: "GGTaseI activity" EXACT [] synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59] synonym: "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59] xref: EC:2.5.1.59 xref: GO:0004662 is_a: CCO:F0001034 ! protein geranylgeranyltransferase activity [Term] id: CCO:F0001036 name: Rab-protein geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "GGTase-II activity" EXACT [] synonym: "GGTaseII activity" EXACT [] synonym: "protein geranylgeranyltransferase type II activity" EXACT [] synonym: "Rab geranylgeranyltransferase activity" EXACT [] synonym: "RabGGTase activity" EXACT [] synonym: "type II protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.60] xref: EC:2.5.1.60 xref: GO:0004663 is_a: CCO:F0001034 ! protein geranylgeranyltransferase activity [Term] id: CCO:F0001037 name: prephenate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51] subset: gosubset_prok synonym: "prephenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.51] synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" EXACT [EC:4.2.1.51] xref: EC:4.2.1.51 xref: GO:0004664 xref: MetaCyc:PREPHENATEDEHYDRAT-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0001038 name: prephenate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+." [EC:1.3.1.13] subset: gosubset_prok synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.3.1.13] synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.13] xref: EC:1.3.1.13 xref: GO:0004665 xref: MetaCyc:PREPHENATE-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001039 name: prostaglandin-endoperoxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1] synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.1] synonym: "(PG)H synthase activity" EXACT [EC:1.14.99.1] synonym: "fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] synonym: "PG synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin endoperoxide synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin G/H synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthetase activity" EXACT [EC:1.14.99.1] xref: EC:1.14.99.1 xref: GO:0004666 xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN xref: Reactome:13496 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001040 name: prostaglandin-D synthase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:5.3.99.2] synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "PGD2 synthase activity" EXACT [EC:5.3.99.2] synonym: "PGH-PGD isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin D2 synthase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-H2 D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-R-prostaglandin D isomerase activity" EXACT [EC:5.3.99.2] xref: EC:5.3.99.2 xref: GO:0004667 xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0001041 name: protein-arginine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3." [EC:3.5.3.15] subset: gosubset_prok synonym: "peptidylarginine deiminase activity" EXACT [EC:3.5.3.15] synonym: "protein-L-arginine iminohydrolase activity" EXACT [EC:3.5.3.15] xref: EC:3.5.3.15 xref: GO:0004668 xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0001042 name: protein-S-isoprenylcysteine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100] subset: gosubset_prok synonym: "farnesyl cysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesyl-protein carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesylated protein C-terminal O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylated protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylcysteine carboxylmethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "S-farnesylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] xref: EC:2.1.1.100 xref: GO:0004671 xref: GO:0018225 xref: MetaCyc:2.1.1.100-RXN is_a: CCO:F0000399 ! C-terminal protein carboxyl methyltransferase activity is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0001043 name: protein kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_candida subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "protamine kinase activity" NARROW [] xref: GO:0004672 xref: GO:0050222 xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:4030 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0001044 name: protein histidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah] subset: gosubset_prok synonym: "ATP:protein-L-histidine N-phosphotransferase activity" EXACT [EC:2.7.13.3] synonym: "EnvZ" NARROW [EC:2.7.13.3] synonym: "histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine kinase activity" EXACT [] synonym: "histidine protein kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine protein kinase activity" EXACT [EC:2.7.13.3] synonym: "HK1" RELATED [EC:2.7.13.3] synonym: "HP165" RELATED [EC:2.7.13.3] synonym: "protein histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine) (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein-histidine kinase activity" EXACT [] synonym: "Sln1p" NARROW [EC:2.7.13.3] xref: EC:2.7.13.3 xref: GO:0004673 xref: GO:0008896 is_a: CCO:F0001043 ! protein kinase activity is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0001045 name: protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate." [GOC:bf] subset: gosubset_prok synonym: "A-kinase activity" NARROW [EC:2.7.11.1] synonym: "AP50 kinase activity" NARROW [EC:2.7.11.1] synonym: "ATP-protein transphosphorylase activity" NARROW [EC:2.7.11.1] synonym: "ATP:protein phosphotransferase (non-specific) activity" NARROW [EC:2.7.11.1] synonym: "betaIIPKC" RELATED [EC:2.7.11.1] synonym: "calcium/phospholipid-dependent protein kinase activity" NARROW [EC:2.7.11.1] synonym: "casein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "cytidine 3',5'-cyclic monophosphate-responsive protein kinase activity" NARROW [EC:2.7.11.1] synonym: "dsk1" RELATED [EC:2.7.11.1] synonym: "epsilon PKC" RELATED [EC:2.7.11.1] synonym: "glycogen synthase a kinase activity" NARROW [EC:2.7.11.1] synonym: "glycogen synthase A kinase activity" NARROW [EC:2.7.11.1] synonym: "glycogen synthase kinase activity" NARROW [EC:2.7.11.1] synonym: "HIPK2" RELATED [EC:2.7.11.1] synonym: "Hpr kinase activity" NARROW [EC:2.7.11.1] synonym: "hydroxyalkyl-protein kinase activity" NARROW [EC:2.7.11.1] synonym: "M phase-specific cdc2 kinase activity" NARROW [EC:2.7.11.1] synonym: "MAPK" RELATED [EC:2.7.11.1] synonym: "mitogen-activated protein kinase activity" BROAD [EC:2.7.11.1] synonym: "mitogen-activated S6 kinase activity" NARROW [EC:2.7.11.1] synonym: "non-specific serine/threonine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "p82 kinase activity" NARROW [EC:2.7.11.1] synonym: "phosphorylase B kinase kinase activity" NARROW [EC:2.7.11.1] synonym: "phosphorylase b kinase kinase activity" BROAD [EC:2.7.11.1] synonym: "PKA" RELATED [EC:2.7.11.1] synonym: "PKC" RELATED [EC:2.7.11.1] synonym: "protein glutamyl kinase activity" NARROW [EC:2.7.11.1] synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "protein kinase A activity" BROAD [EC:2.7.11.1] synonym: "protein kinase p58 activity" NARROW [EC:2.7.11.1] synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine-threonine kinase activity" EXACT [EC:2.7.11.1] synonym: "protein-aspartyl kinase activity" RELATED [EC:2.7.11.1] synonym: "protein-cysteine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] synonym: "Prp4 protein kinase activity" NARROW [EC:2.7.11.1] synonym: "Raf kinase activity" NARROW [EC:2.7.11.1] synonym: "Raf-1" RELATED [EC:2.7.11.1] synonym: "ribosomal protein S6 kinase II activity" NARROW [EC:2.7.11.1] synonym: "ribosomal S6 protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1] synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1] synonym: "STK32" RELATED [EC:2.7.11.1] synonym: "T-antigen kinase activity" NARROW [EC:2.7.11.1] synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "twitchin kinase activity" NARROW [EC:2.7.11.1] synonym: "Wee 1-like kinase activity" NARROW [EC:2.7.11.1] synonym: "Wee-kinase activity" NARROW [EC:2.7.11.1] synonym: "WEE1Hu" RELATED [EC:2.7.11.1] xref: EC:2.7.11 xref: GO:0004674 xref: Reactome:4028 is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0001046 name: transmembrane receptor protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + receptor-protein serine/threonine = ADP + receptor-protein serine/threonine phosphate." [EC:2.7.11.30] synonym: "activin receptor kinase activity" NARROW [EC:2.7.11.30] synonym: "ATP:receptor-protein phosphotransferase activity" EXACT [EC:2.7.11.30] synonym: "receptor protein serine/threonine kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor serine/threonine protein kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor type I serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "receptor type II serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "STK13" RELATED [EC:2.7.11.30] synonym: "TGF-beta kinase activity" NARROW [EC:2.7.11.30] xref: EC:2.7.11.- xref: GO:0004675 xref: Reactome:11160 is_a: CCO:F0001068 ! receptor signaling protein serine/threonine kinase activity is_a: CCO:F0004122 ! transmembrane receptor protein kinase activity [Term] id: CCO:F0001047 name: 3-phosphoinositide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a 3-phosphoinositide." [GOC:mah] xref: EC:2.7.11.- xref: GO:0004676 xref: Reactome:13519 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001048 name: DNA-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, requiring the presence of DNA." [GOC:mah] xref: EC:2.7.11.- xref: GO:0004677 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001049 name: AMP-activated protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of AMP." [GOC:mah] synonym: "5'-AMP-activated protein kinase activity" EXACT [] synonym: "SNF1A/AMP-activated protein kinase activity" NARROW [] xref: EC:2.7.11.- xref: GO:0004679 xref: Reactome:13522 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001050 name: casein kinase activity namespace: molecular_function xref: EC:2.7.11.- xref: GO:0004680 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001051 name: casein kinase I activity namespace: molecular_function xref: EC:2.7.11.- xref: GO:0004681 is_a: CCO:F0001050 ! casein kinase activity [Term] id: CCO:F0001052 name: protein kinase CK2 activity namespace: molecular_function def: "Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1] synonym: "casein kinase II activity" RELATED [] synonym: "casein kinase II, catalytic activity" EXACT [] synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT [] xref: GO:0004682 xref: GO:0008604 is_a: CCO:F0001050 ! casein kinase activity [Term] id: CCO:F0001053 name: calmodulin-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] subset: gosubset_prok synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17] synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/CaM-dependent kinase activity" EXACT [] synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT [] synonym: "calcium/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17] synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17] synonym: "calmodulin regulated protein kinase activity" EXACT [] synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17] synonym: "calmodulin-dependent protein kinase I activity" NARROW [] synonym: "CaM kinase activity" EXACT [EC:2.7.11.17] synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17] synonym: "CAM PKII" RELATED [EC:2.7.11.17] synonym: "CaM-regulated serine/threonine kinase activity" EXACT [EC:2.7.11.17] synonym: "CaMKI" RELATED [EC:2.7.11.17] synonym: "CaMKII" RELATED [EC:2.7.11.17] synonym: "CaMKIV" RELATED [EC:2.7.11.17] synonym: "CaMKKalpha" RELATED [EC:2.7.11.17] synonym: "CaMKKbeta" RELATED [EC:2.7.11.17] synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17] synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED [] synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED [] synonym: "STK20" RELATED [EC:2.7.11.17] xref: EC:2.7.11.17 xref: GO:0004683 xref: GO:0004684 xref: GO:0004685 xref: GO:0004688 xref: MetaCyc:2.7.11.17-RXN is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001054 name: elongation factor-2 kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of eukaryotic elongation factor-2." [GOC:jl, PMID:11904175] synonym: "ATP:elongation factor 2 phosphotransferase activity" EXACT [EC:2.7.11.20] synonym: "Ca/CaM-kinase III activity" EXACT [EC:2.7.11.20] synonym: "calmodulin-dependent protein kinase III activity" EXACT [EC:2.7.11.20] synonym: "CaM kinase III activity" EXACT [EC:2.7.11.20] synonym: "eEF-2 kinase activity" EXACT [] synonym: "eEF2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eEF2K" RELATED [EC:2.7.11.20] synonym: "EF2K" RELATED [EC:2.7.11.20] synonym: "elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "STK19" RELATED [EC:2.7.11.20] xref: EC:2.7.11.20 xref: GO:0004686 is_a: CCO:F0001053 ! calmodulin-dependent protein kinase activity [Term] id: CCO:F0001055 name: myosin light chain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (myosin-light-chain) = ADP + (myosin-light-chain) phosphate." [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase activity" EXACT [EC:2.7.11.18] synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" EXACT [EC:2.7.11.18] synonym: "MLCK" RELATED [EC:2.7.11.18] synonym: "MLCkase activity" EXACT [EC:2.7.11.18] synonym: "myosin kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light chain protein kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating)" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating) activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin-light-chain kinase activity" EXACT [] synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18] synonym: "STK18" RELATED [EC:2.7.11.18] xref: EC:2.7.11.18 xref: GO:0004687 xref: MetaCyc:MYOSIN-LIGHT-CHAIN-KINASE-RXN is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001056 name: phosphorylase kinase activity namespace: molecular_function def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19] subset: gosubset_prok synonym: "ATP:phosphorylase-b phosphotransferase activity" EXACT [EC:2.7.11.19] synonym: "dephosphophosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "glycogen phosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "PHK" RELATED [EC:2.7.11.19] synonym: "phosphorylase b kinase activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase B kinase activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT [] synonym: "STK17" RELATED [EC:2.7.11.19] xref: EC:2.7.11.19 xref: GO:0004689 xref: GO:0008606 xref: MetaCyc:PHOSPHORYLASE-KINASE-RXN xref: Reactome:13545 is_a: CCO:F0001053 ! calmodulin-dependent protein kinase activity [Term] id: CCO:F0001057 name: cyclic nucleotide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a cyclic nucleotide." [GOC:mah] xref: EC:2.7.11.- xref: GO:0004690 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001058 name: cAMP-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cAMP." [EC:2.7.11.11] synonym: "3',5' cAMP-dependent protein kinase activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [] synonym: "AMPK" RELATED [EC:2.7.11.11] synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [EC:2.7.11.11] synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "cyclic AMP-dependent protein kinase activity" EXACT [] synonym: "PKA" RELATED [EC:2.7.11.11] synonym: "PKA C" RELATED [EC:2.7.11.11] synonym: "protein kinase A activity" BROAD [EC:2.7.11.11] synonym: "STK22" RELATED [EC:2.7.11.11] xref: EC:2.7.11.11 xref: GO:0004691 xref: GO:0008602 xref: Reactome:13562 is_a: CCO:F0001057 ! cyclic nucleotide-dependent protein kinase activity [Term] id: CCO:F0001059 name: cGMP-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cGMP." [GOC:mah] synonym: "3':5'-cyclic GMP-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" EXACT [EC:2.7.11.12] synonym: "cGMP-dependent protein kinase ibeta activity" EXACT [EC:2.7.11.12] synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "PKG" RELATED [EC:2.7.11.12] synonym: "PKG 1alpha" RELATED [EC:2.7.11.12] synonym: "PKG 1beta" RELATED [EC:2.7.11.12] synonym: "PKG II" RELATED [EC:2.7.11.12] synonym: "STK23" RELATED [EC:2.7.11.12] xref: EC:2.7.11.12 xref: GO:0004692 is_a: CCO:F0001057 ! cyclic nucleotide-dependent protein kinase activity [Term] id: CCO:F0001060 name: cyclin-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:rn, PMID:7877684, PMID:9841670] synonym: "ATP:cyclin phosphotransferase activity" EXACT [EC:2.7.11.22] synonym: "Bur1" RELATED [EC:2.7.11.22] synonym: "Bur1 Cdk" RELATED [EC:2.7.11.22] synonym: "Cak1" RELATED [EC:2.7.11.22] synonym: "Cak1p" RELATED [EC:2.7.11.22] synonym: "cdc2" RELATED [EC:2.7.11.22] synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22] synonym: "Cdc28p" RELATED [EC:2.7.11.22] synonym: "CDK" RELATED [EC:2.7.11.22] synonym: "CDK activity" EXACT [] synonym: "CDK, catalytic subunit activity" EXACT [] synonym: "cdk-activating kinase activity" EXACT [EC:2.7.11.22] synonym: "Cdk-activating protein kinase activity" EXACT [EC:2.7.11.22] synonym: "cdk1" RELATED [EC:2.7.11.22] synonym: "cdk2" RELATED [EC:2.7.11.22] synonym: "Cdk2" RELATED [EC:2.7.11.22] synonym: "cdk3" RELATED [EC:2.7.11.22] synonym: "cdk4" RELATED [EC:2.7.11.22] synonym: "cdk5" RELATED [EC:2.7.11.22] synonym: "cdk6" RELATED [EC:2.7.11.22] synonym: "cdk7" RELATED [EC:2.7.11.22] synonym: "cdk8" RELATED [EC:2.7.11.22] synonym: "cdk9" RELATED [EC:2.7.11.22] synonym: "cyclin A-activated cdc2" RELATED [EC:2.7.11.22] synonym: "cyclin A-activated cdk2" RELATED [EC:2.7.11.22] synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22] synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "cyk" RELATED [EC:2.7.11.22] synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22] synonym: "nclk" RELATED [EC:2.7.11.22] synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22] synonym: "PCTAIRE-1" RELATED [EC:2.7.11.22] synonym: "STK25" RELATED [EC:2.7.11.22] xref: EC:2.7.11.22 xref: GO:0004693 xref: GO:0016537 xref: Reactome:13565 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001061 name: eukaryotic translation initiation factor 2alpha kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (EIF2)." [GOC:mah, InterPro:IPR015516] xref: EC:2.7.11.- xref: GO:0004694 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001062 name: galactosyltransferase-associated kinase activity namespace: molecular_function xref: EC:2.7.11.- xref: GO:0004695 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001063 name: glycogen synthase kinase 3 activity namespace: molecular_function xref: EC:2.7.11.- xref: GO:0004696 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001064 name: protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol." [EC:2.7.11.13] synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" EXACT [EC:2.7.11.13] synonym: "cPKC" RELATED [EC:2.7.11.13] synonym: "cPKCalpha" RELATED [EC:2.7.11.13] synonym: "cPKCbeta" RELATED [EC:2.7.11.13] synonym: "cPKCgamma" RELATED [EC:2.7.11.13] synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT [] synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT [] synonym: "nPKC" RELATED [EC:2.7.11.13] synonym: "nPKCdelta" RELATED [EC:2.7.11.13] synonym: "nPKCepsilon" RELATED [EC:2.7.11.13] synonym: "nPKCeta" RELATED [EC:2.7.11.13] synonym: "nPKCtheta" RELATED [EC:2.7.11.13] synonym: "PKC" RELATED [EC:2.7.11.13] synonym: "PKC activity" EXACT [] synonym: "Pkc1p" RELATED [EC:2.7.11.13] synonym: "PKCalpha" RELATED [EC:2.7.11.13] synonym: "PKCbeta" RELATED [EC:2.7.11.13] synonym: "PKCdelta" RELATED [EC:2.7.11.13] synonym: "PKCepsilon" RELATED [EC:2.7.11.13] synonym: "PKCgamma" RELATED [EC:2.7.11.13] synonym: "PKCzeta" RELATED [EC:2.7.11.13] synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13] synonym: "STK24" RELATED [EC:2.7.11.13] xref: EC:2.7.11.13 xref: GO:0004697 xref: GO:0004701 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001065 name: calcium-dependent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol and calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-dependent PKC activity" EXACT [] xref: EC:2.7.11.- xref: GO:0004698 xref: Reactome:13572 is_a: CCO:F0001064 ! protein kinase C activity [Term] id: CCO:F0001066 name: calcium-independent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-independent PKC activity" EXACT [] xref: GO:0004699 is_a: CCO:F0001064 ! protein kinase C activity [Term] id: CCO:F0001067 name: atypical protein kinase C activity namespace: molecular_function synonym: "atypical PKC activity" EXACT [] xref: EC:2.7.11.- xref: GO:0004700 is_a: CCO:F0001064 ! protein kinase C activity [Term] id: CCO:F0001068 name: receptor signaling protein serine/threonine kinase activity namespace: molecular_function synonym: "receptor signalling protein serine/threonine kinase activity" EXACT [] xref: EC:2.7.11.- xref: GO:0004702 is_a: CCO:F0001045 ! protein serine/threonine kinase activity is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001069 name: G-protein coupled receptor kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a G-protein coupled receptor, thereby modulating its activity." [GOC:dph] synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" EXACT [EC:2.7.11.16] synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "G protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "GPCR kinase activity" EXACT [EC:2.7.11.16] synonym: "GPCR phosphorylating protein kinase activity" EXACT [] synonym: "GPCRK" RELATED [EC:2.7.11.16] synonym: "GRK4" RELATED [EC:2.7.11.16] synonym: "GRK5" RELATED [EC:2.7.11.16] synonym: "GRK6" RELATED [EC:2.7.11.16] synonym: "STK16" RELATED [EC:2.7.11.16] xref: EC:2.7.11.16 xref: GO:0004678 xref: GO:0004703 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001070 name: NF-kappaB-inducing kinase activity namespace: molecular_function synonym: "NIK" EXACT [] xref: EC:2.7.11.- xref: GO:0004704 is_a: CCO:F0001068 ! receptor signaling protein serine/threonine kinase activity [Term] id: CCO:F0001071 name: JUN kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "c-Jun N-terminal kinase activity" NARROW [] synonym: "JNK" EXACT [] synonym: "JNK3alpha1" RELATED [] synonym: "SAPK1" NARROW [] xref: EC:2.7.11.- xref: GO:0004705 is_a: CCO:F0003465 ! SAP kinase activity [Term] id: CCO:F0001072 name: JUN kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf] synonym: "JNK kinase kinase activity" RELATED [] synonym: "JNKKK" EXACT [] xref: EC:2.7.11.- xref: GO:0004706 is_a: CCO:F0001075 ! MAP kinase kinase kinase activity [Term] id: CCO:F0001073 name: MAP kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" EXACT [EC:2.7.11.24] synonym: "Dp38" RELATED [EC:2.7.11.24] synonym: "ERK" RELATED [EC:2.7.11.24] synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24] synonym: "LeMPK3" RELATED [EC:2.7.11.24] synonym: "MAP-2 kinase activity" NARROW [EC:2.7.11.24] synonym: "MAPK" RELATED [EC:2.7.11.24] synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24] synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24] synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.24] synonym: "microtubule-associated protein kinase activity" EXACT [EC:2.7.11.24] synonym: "mitogen activated kinase activity" EXACT [] synonym: "mitogen-activated protein kinase activity" EXACT [EC:2.7.11.24] synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p38-2" RELATED [EC:2.7.11.24] synonym: "p38delta" RELATED [EC:2.7.11.24] synonym: "p42 mitogen-activated protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p42mapk" RELATED [EC:2.7.11.24] synonym: "p44mpk" RELATED [EC:2.7.11.24] synonym: "PMK-1" RELATED [EC:2.7.11.24] synonym: "PMK-2" RELATED [EC:2.7.11.24] synonym: "PMK-3" RELATED [EC:2.7.11.24] synonym: "pp42" RELATED [EC:2.7.11.24] synonym: "pp44mapk" RELATED [EC:2.7.11.24] synonym: "STK26" RELATED [EC:2.7.11.24] xref: EC:2.7.11.24 xref: GO:0004707 xref: Reactome:4049 is_a: CCO:F0001068 ! receptor signaling protein serine/threonine kinase activity [Term] id: CCO:F0001074 name: MAP kinase kinase activity namespace: molecular_function def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase." [ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" EXACT [EC:2.7.12.2] synonym: "ERK activator kinase activity" EXACT [] synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2] synonym: "MAP2K" RELATED [EC:2.7.12.2] synonym: "MAPKK" RELATED [EC:2.7.12.2] synonym: "MAPKK activity" EXACT [] synonym: "MAPKK1" RELATED [EC:2.7.12.2] synonym: "MEK activity" BROAD [] synonym: "MEK1" RELATED [EC:2.7.12.2] synonym: "MEK2" RELATED [EC:2.7.12.2] synonym: "mitogen-activated protein kinase kinase activity" EXACT [EC:2.7.12.2] synonym: "MKK" RELATED [EC:2.7.12.2] synonym: "MKK2" RELATED [EC:2.7.12.2] synonym: "MKK4" RELATED [EC:2.7.12.2] synonym: "MKK6" RELATED [EC:2.7.12.2] synonym: "MKK7" RELATED [EC:2.7.12.2] synonym: "STK27" RELATED [EC:2.7.12.2] xref: EC:2.7.11.- xref: GO:0004708 is_a: CCO:F0001078 ! protein serine/threonine/tyrosine kinase activity [Term] id: CCO:F0001075 name: MAP kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" EXACT [EC:2.7.11.25] synonym: "cMos" RELATED [EC:2.7.11.25] synonym: "cRaf" RELATED [EC:2.7.11.25] synonym: "MAP3K" RELATED [EC:2.7.11.25] synonym: "MAPKKK activity" EXACT [EC:2.7.11.25] synonym: "MEK kinase activity" EXACT [EC:2.7.11.25] synonym: "MEKK" RELATED [EC:2.7.11.25] synonym: "MEKK1" RELATED [EC:2.7.11.25] synonym: "MEKK2" RELATED [EC:2.7.11.25] synonym: "MEKK3" RELATED [EC:2.7.11.25] synonym: "Mil/Raf" RELATED [EC:2.7.11.25] synonym: "mitogen-activated protein kinase kinase kinase activity" EXACT [EC:2.7.11.25] synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25] synonym: "MLTK" RELATED [EC:2.7.11.25] synonym: "MLTKa" RELATED [EC:2.7.11.25] synonym: "MLTKb" RELATED [EC:2.7.11.25] synonym: "REKS" RELATED [EC:2.7.11.25] synonym: "STK28" RELATED [EC:2.7.11.25] xref: EC:2.7.11.25 xref: GO:0004709 is_a: CCO:F0001068 ! receptor signaling protein serine/threonine kinase activity [Term] id: CCO:F0001076 name: MAP/ERK kinase kinase activity namespace: molecular_function synonym: "MEKK activity" EXACT [] xref: EC:2.7.11.- xref: GO:0004710 is_a: CCO:F0001075 ! MAP kinase kinase kinase activity [Term] id: CCO:F0001077 name: ribosomal protein S6 kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of ribosomal protein S6." [GOC:mah, PMID:9822608] xref: EC:2.7.11.- xref: GO:0004711 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001078 name: protein serine/threonine/tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein serine/threonine/tyrosine = ADP + protein serine/threonine/tyrosine phosphate." [GOC:mah] subset: gosubset_prok synonym: "ADK1" RELATED [EC:2.7.12.1] synonym: "Arabidopsis dual specificity kinase 1 activity" NARROW [EC:2.7.12.1] synonym: "ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity" EXACT [EC:2.7.12.1] synonym: "CLK1" RELATED [EC:2.7.12.1] synonym: "dDYRK2" RELATED [EC:2.7.12.1] synonym: "dual-specificity kinase activity" BROAD [EC:2.7.12.1] synonym: "dual-specificity protein kinase" BROAD [] synonym: "Mps1p" RELATED [EC:2.7.12.1] synonym: "protein threonine/tyrosine kinase activity" NARROW [] xref: EC:2.7.112.1 xref: GO:0004712 is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0001080 name: transmembrane receptor protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity." [EC:2.7.10.1, GOC:mah] subset: gosubset_prok synonym: "anaplastic lymphoma kinase activity" NARROW [EC:2.7.10.1] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity" EXACT [EC:2.7.10.1] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.1] synonym: "Drosophila Eph kinase activity" NARROW [EC:2.7.10.1] synonym: "ephrin-B3 receptor tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "insulin receptor protein-tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "neurite outgrowth regulating kinase activity" NARROW [EC:2.7.10.1] synonym: "neurotrophin TRK receptor activity" RELATED [] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "neurotrophin TRKC receptor activity" RELATED [] synonym: "novel oncogene with kinase-domain activity" NARROW [EC:2.7.10.1] synonym: "receptor protein tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "receptor protein-tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "sevenless receptor activity" RELATED [] xref: EC:2.7.10.1 xref: GO:0004714 xref: Reactome:11064 is_a: CCO:F0004122 ! transmembrane receptor protein kinase activity is_a: CCO:F0008374 ! protein tyrosine kinase activity [Term] id: CCO:F0001081 name: non-membrane spanning protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [EC:2.7.10.2] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2] synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2] synonym: "non-specific protein-tyrosine kinase activity" EXACT [EC:2.7.10.2] synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2] xref: EC:2.7.10.2 xref: GO:0004715 is_a: CCO:F0008374 ! protein tyrosine kinase activity [Term] id: CCO:F0001082 name: receptor signaling protein tyrosine kinase activity namespace: molecular_function synonym: "receptor signalling protein tyrosine kinase activity" EXACT [] xref: EC:2.7.10.- xref: GO:0004716 is_a: CCO:F0001374 ! receptor signaling protein activity is_a: CCO:F0008374 ! protein tyrosine kinase activity [Term] id: CCO:F0001083 name: Janus kinase activity namespace: molecular_function synonym: "JAK" EXACT [] xref: EC:2.7.11.- xref: GO:0004718 is_a: CCO:F0001082 ! receptor signaling protein tyrosine kinase activity [Term] id: CCO:F0001084 name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] subset: gosubset_prok synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein (D-aspartate) methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein D-aspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein O-methyltransferase (L-isoaspartate)" EXACT [EC:2.1.1.77] synonym: "protein-beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] xref: EC:2.1.1.77 xref: GO:0004719 xref: MetaCyc:2.1.1.77-RXN is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0001813 ! protein methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0001085 name: protein-lysine 6-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + H2O2." [EC:1.4.3.13] synonym: "lysyl oxidase activity" EXACT [EC:1.4.3.13] synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" EXACT [EC:1.4.3.13] xref: EC:1.4.3.13 xref: GO:0004720 xref: GO:0018056 xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0001086 name: phosphoprotein phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16] synonym: "protein phosphatase activity" EXACT [] synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16] xref: EC:3.1.3.16 xref: GO:0004721 xref: MetaCyc:3.1.3.16-RXN xref: Reactome:1887 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0001087 name: protein serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:bf] subset: gosubset_prok synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16] synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "calcineurin" NARROW [] synonym: "casein phosphatase" NARROW [EC:3.1.3.16] synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphatase 2A" NARROW [EC:3.1.3.16] synonym: "phosphatase 2B" NARROW [EC:3.1.3.16] synonym: "phosphatase C-II" NARROW [EC:3.1.3.16] synonym: "phosphatase H-II" NARROW [EC:3.1.3.16] synonym: "phosphatase I" NARROW [EC:3.1.3.16] synonym: "phosphatase IB" NARROW [EC:3.1.3.16] synonym: "phosphatase II" NARROW [EC:3.1.3.16] synonym: "phosphatase III" NARROW [EC:3.1.3.16] synonym: "phosphatase IV" NARROW [EC:3.1.3.16] synonym: "phosphatase SP" NARROW [EC:3.1.3.16] synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16] synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16] synonym: "protein D phosphatase" NARROW [EC:3.1.3.16] synonym: "protein phosphatase type 1 activity" NARROW [] synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2A activity" NARROW [] synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2B activity" NARROW [] synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2C activity" NARROW [] synonym: "protein phosphatase type 4 activity" NARROW [] synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase X" NARROW [] synonym: "serine/threonine specific protein phosphatase activity" EXACT [] xref: GO:0000158 xref: GO:0000163 xref: GO:0004722 xref: GO:0008598 xref: GO:0008600 xref: GO:0015071 xref: GO:0030357 xref: GO:0030358 xref: GO:0030360 xref: GO:0030361 xref: Reactome:21718 is_a: CCO:F0001086 ! phosphoprotein phosphatase activity [Term] id: CCO:F0001088 name: calcium-dependent protein serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium ions." [EC:3.1.3.16, GOC:mah] synonym: "calcineurin" NARROW [] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT [] xref: GO:0004723 xref: GO:0008596 is_a: CCO:F0001087 ! protein serine/threonine phosphatase activity [Term] id: CCO:F0001089 name: magnesium-dependent protein serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the removal of a serine- or threonine-bound phosphate group from a protein; action dependent on magnesium." [EC:3.1.3.16] xref: GO:0004724 is_a: CCO:F0001087 ! protein serine/threonine phosphatase activity [Term] id: CCO:F0001090 name: protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] subset: gosubset_prok synonym: "[phosphotyrosine]protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine histone phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PPT-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.48] synonym: "PTP-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PTPase activity" EXACT [EC:3.1.3.48] synonym: "tyrosine O-phosphate phosphatase activity" EXACT [EC:3.1.3.48] synonym: "tyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] xref: EC:3.1.3.48 xref: GO:0004725 xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN xref: Reactome:11061 is_a: CCO:F0001086 ! phosphoprotein phosphatase activity [Term] id: CCO:F0001091 name: non-membrane spanning protein tyrosine phosphatase activity namespace: molecular_function subset: gosubset_prok xref: GO:0004726 is_a: CCO:F0001090 ! protein tyrosine phosphatase activity [Term] id: CCO:F0001092 name: prenylated protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48] xref: GO:0004727 is_a: CCO:F0001090 ! protein tyrosine phosphatase activity [Term] id: CCO:F0001093 name: receptor signaling protein tyrosine phosphatase activity namespace: molecular_function synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT [] xref: GO:0004728 is_a: CCO:F0001090 ! protein tyrosine phosphatase activity is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001094 name: protoporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2." [EC:1.3.3.4] subset: gosubset_prok synonym: "protoporphyrinogen IX oxidase activity" EXACT [EC:1.3.3.4] synonym: "protoporphyrinogen-IX oxidase activity" EXACT [EC:1.3.3.4] synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" EXACT [EC:1.3.3.4] synonym: "protoporphyrinogenase activity" EXACT [EC:1.3.3.4] xref: EC:1.3.3.4 xref: GO:0004729 xref: MetaCyc:PROTOPORGENOXI-RXN xref: Reactome:14184 is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0001095 name: pseudouridylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O." [EC:4.2.1.70] comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine. subset: gosubset_prok synonym: "5-ribosyluracil 5-phosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridine monophosphate synthase activity" EXACT [] synonym: "pseudouridine monophosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridylate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridylic acid synthetase activity" EXACT [EC:4.2.1.70] synonym: "psiUMP synthetase activity" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" EXACT [EC:4.2.1.70] synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70] xref: EC:4.2.1.70 xref: GO:0004730 xref: MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0001096 name: purine-nucleoside phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1] subset: gosubset_prok synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1] synonym: "inosine-guanosine phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "PNPase activity" EXACT [EC:2.4.2.1] synonym: "PUNPI" RELATED [EC:2.4.2.1] synonym: "PUNPII" RELATED [EC:2.4.2.1] synonym: "purine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine deoxyribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine nucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine ribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine-nucleoside:phosphate ribosyltransferase activity" EXACT [EC:2.4.2.1] xref: EC:2.4.2.1 xref: GO:0004731 xref: MetaCyc:PNP-RXN xref: Reactome:14201 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0001097 name: pyridoxal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + H2O2." [EC:1.2.3.8] synonym: "pyridoxal:oxygen 4-oxidoreductase activity" EXACT [EC:1.2.3.8] xref: EC:1.2.3.8 xref: GO:0004732 xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0001098 name: pyridoxamine-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2." [EC:1.4.3.5] subset: gosubset_prok synonym: "PdxH" RELATED [EC:1.4.3.5] synonym: "PMP oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxal 5'-phosphate synthase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] xref: EC:1.4.3.5 xref: GO:0004733 xref: MetaCyc:PMPOXI-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0001099 name: pyrimidodiazepine synthase activity namespace: molecular_function def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1] synonym: "PDA synthase activity" EXACT [EC:1.5.4.1] synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1] xref: EC:1.5.4.1 xref: GO:0004734 xref: MetaCyc:1.5.4.1-RXN is_a: CCO:F0003247 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor [Term] id: CCO:F0001100 name: pyrroline-5-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2] subset: gosubset_prok synonym: "1-pyrroline-5-carboxylate reductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline oxidase activity" EXACT [EC:1.5.1.2] synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [EC:1.5.1.2] synonym: "P5CR activity" EXACT [EC:1.5.1.2] xref: EC:1.5.1.2 xref: GO:0004735 xref: MetaCyc:PYRROLINECARBREDUCT-RXN xref: Reactome:14208 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001101 name: pyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate." [EC:6.4.1.1] subset: gosubset_prok synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.1] synonym: "pyruvic carboxylase activity" EXACT [EC:6.4.1.1] xref: EC:6.4.1.1 xref: GO:0004736 xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN xref: Reactome:14209 is_a: CCO:F0003443 ! ligase activity, forming carbon-carbon bonds [Term] id: CCO:F0001102 name: pyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1] subset: gosubset_prok synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" EXACT [EC:4.1.1.1] synonym: "2-oxo-acid carboxy-lyase activity" EXACT [EC:4.1.1.1] synonym: "alpha-carboxylase activity" EXACT [EC:4.1.1.1] synonym: "alpha-ketoacid carboxylase activity" EXACT [EC:4.1.1.1] synonym: "pyruvic decarboxylase activity" EXACT [EC:4.1.1.1] xref: EC:4.1.1.1 xref: GO:0004737 xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0001103 name: pyruvate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716020094] subset: gosubset_prok synonym: "pyruvic acid dehydrogenase activity" EXACT [EC:1.2.4.1] synonym: "pyruvic dehydrogenase activity" EXACT [EC:1.2.4.1] xref: GO:0004738 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0001104 name: pyruvate dehydrogenase (acetyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1] subset: gosubset_prok synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1] synonym: "PDH" RELATED [EC:1.2.4.1] synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT [] synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1] synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1] synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1] xref: EC:1.2.4.1 xref: GO:0004739 xref: MetaCyc:PYRUVATEDECARB-RXN xref: Reactome:14213 is_a: CCO:F0001103 ! pyruvate dehydrogenase activity is_a: CCO:F0003226 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: CCO:F0001105 name: pyruvate dehydrogenase (acetyl-transferring) kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2] synonym: "[pyruvate dehydrogenase (lipoamide)] kinase activity" EXACT [] synonym: "ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.2] synonym: "PDH kinase activity" EXACT [EC:2.7.11.2] synonym: "PDHK" RELATED [EC:2.7.11.2] synonym: "PDK" RELATED [EC:2.7.11.2] synonym: "PDK1" RELATED [EC:2.7.11.2] synonym: "PDK2" RELATED [EC:2.7.11.2] synonym: "PDK3" RELATED [EC:2.7.11.2] synonym: "PDK4" RELATED [EC:2.7.11.2] synonym: "pyruvate dehydrogenase (lipoamide) kinase activity" EXACT [] synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activator protein activity" NARROW [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activity" EXACT [EC:2.7.11.2] synonym: "STK1" RELATED [EC:2.7.11.2] xref: EC:2.7.11.2 xref: GO:0004740 xref: MetaCyc:2.7.11.2-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0001107 name: dihydrolipoyllysine-residue acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12] subset: gosubset_prok synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT [] synonym: "dihydrolipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoyl acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acid acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoylacetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12] synonym: "transacetylase X activity" NARROW [EC:2.3.1.12] xref: EC:2.3.1.12 xref: GO:0004742 xref: MetaCyc:DIHYDLIPACETRANS-RXN xref: Reactome:14238 is_a: CCO:F0003141 ! S-acetyltransferase activity is_a: CCO:F0004452 ! dihydrolipoamide S-acyltransferase activity [Term] id: CCO:F0001108 name: pyruvate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40] subset: gosubset_prok synonym: "ATP:pyruvate 2-O-phosphotransferase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40] xref: EC:2.7.1.40 xref: GO:0004743 xref: MetaCyc:PEPDEPHOS-RXN xref: Reactome:14240 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0001109 name: retinal isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [EC:5.2.1.3] synonym: "all-trans-retinal 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.3] synonym: "retinene isomerase activity" RELATED [EC:5.2.1.3] synonym: "retinoid isomerase activity" BROAD [EC:5.2.1.3] xref: EC:5.2.1.3 xref: GO:0004744 xref: MetaCyc:RETINAL-ISOMERASE-RXN is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0001110 name: retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105] subset: gosubset_prok synonym: "all-trans retinol dehydrogenase activity" EXACT [EC:1.1.1.105] synonym: "MDR" RELATED [EC:1.1.1.105] synonym: "microsomal retinol dehydrogenase activity" EXACT [EC:1.1.1.105] synonym: "retinene reductase activity" EXACT [EC:1.1.1.105] synonym: "retinol (vitamin A1) dehydrogenase activity" EXACT [EC:1.1.1.105] synonym: "retinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.105] xref: EC:1.1.1.105 xref: GO:0004745 xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001111 name: riboflavin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine." [EC:2.5.1.9] subset: gosubset_prok synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" EXACT [EC:2.5.1.9] synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "lumazine synthase activity" BROAD [BRENDA:2.5.1.9] synonym: "riboflavin synthetase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthetase activity" EXACT [EC:2.5.1.9] synonym: "vitamin B2 synthase activity" EXACT [] xref: EC:2.5.1.9 xref: GO:0004746 xref: MetaCyc:RIBOFLAVIN-SYN-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0001112 name: ribokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15] subset: gosubset_prok synonym: "ATP:D-ribose 5-phosphotransferase activity" EXACT [EC:2.7.1.15] synonym: "D-ribokinase activity" EXACT [EC:2.7.1.15] synonym: "deoxyribokinase activity" EXACT [EC:2.7.1.15] synonym: "ribokinase (phosphorylating)" EXACT [EC:2.7.1.15] xref: EC:2.7.1.15 xref: GO:0004747 xref: MetaCyc:RIBOKIN-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0001113 name: ribonucleoside-diphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1] subset: gosubset_prok synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] synonym: "nucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED [] synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "ribonucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "ribonucleotide diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.1] synonym: "RNR" EXACT [] xref: EC:1.17.4.1 xref: GO:0004748 xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN is_a: CCO:F0003310 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [Term] id: CCO:F0001114 name: ribose phosphate diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.7.6.1] subset: gosubset_prok synonym: "5-phosphoribose pyrophosphorylase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl-diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "PP-ribose P synthetase activity" EXACT [EC:2.7.6.1] synonym: "PPRibP synthetase activity" EXACT [EC:2.7.6.1] synonym: "PRPP synthetase activity" EXACT [EC:2.7.6.1] synonym: "pyrophosphoribosylphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ribophosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-5-phosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate diphosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate pyrophosphokinase activity" EXACT [] xref: EC:2.7.6.1 xref: GO:0004749 xref: MetaCyc:PRPPSYN-RXN xref: MetaCyc:PWY0-662 xref: Reactome:14245 is_a: CCO:F0003350 ! diphosphotransferase activity is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0001115 name: ribulose-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1] subset: gosubset_prok synonym: "D-ribulose 5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose phosphate-3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-P 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-xylulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate isomerase activity" EXACT [EC:5.1.3.1] synonym: "pentose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoribulose epimerase activity" EXACT [EC:5.1.3.1] synonym: "ribulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "xylulose phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] xref: EC:5.1.3.1 xref: GO:0004750 xref: MetaCyc:RIBULP3EPIM-RXN xref: Reactome:14262 is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0001116 name: ribose-5-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6] subset: gosubset_prok synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6] synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6] synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6] xref: EC:5.3.1.6 xref: GO:0004751 xref: MetaCyc:RIB5PISOM-RXN xref: Reactome:14263 is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0001117 name: saccharopine dehydrogenase activity namespace: molecular_function subset: gosubset_prok synonym: "lysine-2-oxoglutarate reductase activity" EXACT [EC:1.5.1.-] synonym: "lysine-ketoglutarate reductase activity" EXACT [EC:1.5.1.-] xref: EC:1.5.1.- xref: GO:0004753 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001118 name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+." [EC:1.5.1.7] subset: gosubset_prok synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" EXACT [EC:1.5.1.7] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" EXACT [EC:1.5.1.7] synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] xref: EC:1.5.1.7 xref: GO:0004754 xref: MetaCyc:1.5.1.7-RXN xref: Reactome:70922 is_a: CCO:F0001117 ! saccharopine dehydrogenase activity [Term] id: CCO:F0001119 name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADPH + H+." [EC:1.5.1.10] subset: gosubset_prok synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "aminoadipate semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamic reductase activity" EXACT [EC:1.5.1.10] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" EXACT [EC:1.5.1.10] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" EXACT [EC:1.5.1.10] synonym: "saccharopine reductase activity" EXACT [EC:1.5.1.10] xref: EC:1.5.1.10 xref: GO:0004755 xref: MetaCyc:1.5.1.10-RXN xref: Reactome:70935 is_a: CCO:F0001117 ! saccharopine dehydrogenase activity [Term] id: CCO:F0001120 name: selenide, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + selenide + H2O = AMP + selenophosphate + phosphate." [EC:2.7.9.3] subset: gosubset_prok synonym: "ATP:selenide, water phosphotransferase activity" EXACT [EC:2.7.9.3] synonym: "selenide,water dikinase activity" EXACT [EC:2.7.9.3] synonym: "selenium donor protein activity" EXACT [EC:2.7.9.3] synonym: "selenophosphate synthase activity" EXACT [] synonym: "selenophosphate synthetase activity" EXACT [EC:2.7.9.3] xref: EC:2.7.9.3 xref: GO:0004756 xref: MetaCyc:2.7.9.3-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003353 ! phosphotransferase activity, paired acceptors [Term] id: CCO:F0001121 name: sepiapterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153] subset: gosubset_prok synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.153] xref: EC:1.1.1.153 xref: GO:0004757 xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001122 name: serine C-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2." [EC:2.3.1.50] synonym: "3-oxosphinganine synthetase activity" EXACT [EC:2.3.1.50] synonym: "acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [EC:2.3.1.50] synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.50] synonym: "serine palmitoyltransferase" BROAD [] synonym: "SPT" RELATED [EC:2.3.1.50] xref: EC:2.3.1.50 xref: GO:0004758 xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN is_a: CCO:F0003164 ! C-palmitoyltransferase activity [Term] id: CCO:F0001123 name: serine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51] subset: gosubset_prok synonym: "hydroxypyruvate:L-alanine transaminase activity" EXACT [EC:2.6.1.51] synonym: "L-serine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase activity" EXACT [] synonym: "serine-pyruvate aminotransferase, type 1" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2A" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B" NARROW [] synonym: "SPT" RELATED [EC:2.6.1.51] xref: EC:2.6.1.51 xref: GO:0004760 xref: GO:0004761 xref: GO:0004762 xref: GO:0004763 xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0001124 name: shikimate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+." [EC:1.1.1.25] subset: gosubset_prok synonym: "5-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25] synonym: "5-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] synonym: "dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] synonym: "DHS reductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate oxidoreductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate:NADP(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate:NADP(+) oxidoreductase activity" EXACT [EC:1.1.1.25] xref: EC:1.1.1.25 xref: GO:0004764 xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001125 name: shikimate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate." [EC:2.7.1.71] subset: gosubset_prok synonym: "ATP:shikimate 3-phosphotransferase activity" EXACT [EC:2.7.1.71] synonym: "shikimate kinase (phosphorylating)" EXACT [EC:2.7.1.71] synonym: "shikimate kinase II" RELATED [EC:2.7.1.71] xref: EC:2.7.1.71 xref: GO:0004765 xref: MetaCyc:SHIKIMATE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0001126 name: spermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16] subset: gosubset_prok synonym: "aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "putrescine aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "SpeE" RELATED [EC:2.5.1.16] synonym: "spermidine synthetase activity" EXACT [EC:2.5.1.16] xref: EC:2.5.1.16 xref: GO:0004766 xref: MetaCyc:SPERMIDINESYN-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0001127 name: sphingomyelin phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate." [EC:3.1.4.12] subset: gosubset_prok synonym: "acid sphingomyelin phosphodiesterase" NARROW [] synonym: "acid sphingomyelinase activity" NARROW [EC:3.1.4.12] synonym: "neutral sphingomyelin phosphodiesterase" NARROW [] synonym: "neutral sphingomyelinase activity" NARROW [EC:3.1.4.12] synonym: "sphingomyelin cholinephosphohydrolase activity" EXACT [EC:3.1.4.12] synonym: "sphingomyelinase activity" EXACT [] xref: EC:3.1.4.12 xref: GO:0004767 xref: GO:0030230 xref: GO:0030231 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN is_a: CCO:F0000999 ! phospholipase activity is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0001128 name: stearoyl-CoA 9-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] comment: Note that this function was formerly EC:1.14.99.5. subset: gosubset_prok synonym: "acyl-CoA desaturase activity" EXACT [EC:1.14.19.1] synonym: "delta(9)-desaturase activity" EXACT [EC:1.14.19.1] synonym: "delta9-desaturase activity" EXACT [EC:1.14.19.1] synonym: "fatty acid desaturase activity" EXACT [EC:1.14.19.1] synonym: "stearoyl-CoA desaturase activity" EXACT [] synonym: "stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.1] synonym: "stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)" EXACT [EC:1.14.19.1] xref: EC:1.14.19.1 xref: GO:0004768 xref: GO:0016214 xref: MetaCyc:1.14.19.1-RXN is_a: CCO:F0003300 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: CCO:F0001129 name: steroid delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1] subset: gosubset_prok synonym: "3-oxosteroid delta5-delta4-isomerase activity" EXACT [EC:5.3.3.1] synonym: "3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5(or delta4)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "hydroxysteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "steroid D-isomerase activity" EXACT [] synonym: "steroid isomerase activity" EXACT [EC:5.3.3.1] xref: EC:5.3.3.1 xref: GO:0004769 xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0001130 name: sterol carrier protein X-related thiolase activity namespace: molecular_function xref: GO:0004770 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0001131 name: sterol esterase activity namespace: molecular_function def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] synonym: "acylcholesterol lipase activity" EXACT [EC:3.1.1.13] synonym: "cholesterase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13] synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13] synonym: "cholesteryl ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl ester synthase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl esterase activity" EXACT [EC:3.1.1.13] synonym: "sterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "steryl-ester acylhydrolase activity" EXACT [EC:3.1.1.13] synonym: "triterpenol esterase activity" EXACT [EC:3.1.1.13] xref: EC:3.1.1.13 xref: GO:0004771 xref: MetaCyc:STEROL-ESTERASE-RXN xref: Reactome:14316 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0001132 name: sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + cholesterol = CoA + cholesterol ester." [EC:2.3.1.26] synonym: "ACAT" EXACT [] synonym: "acyl coenzyme A-cholesterol-O-acyltransferase activity" EXACT [EC:2.3.1.26] synonym: "acyl-CoA:cholesterol acyltransferase activity" EXACT [EC:2.3.1.26] synonym: "acyl-CoA:cholesterol O-acyltransferase activity" EXACT [EC:2.3.1.26] synonym: "acylcoenzyme A:cholesterol O-acyltransferase activity" EXACT [] synonym: "cholesterol acyltransferase activity" BROAD [EC:2.3.1.26] synonym: "cholesterol ester synthetase activity" EXACT [EC:2.3.1.26] synonym: "cholesterol O-acyltransferase activity" EXACT [] synonym: "cholesteryl ester synthetase activity" EXACT [EC:2.3.1.26] synonym: "sterol-ester synthase activity" EXACT [EC:2.3.1.26] synonym: "sterol-ester synthetase activity" EXACT [EC:2.3.1.26] xref: EC:2.3.1.26 xref: GO:0004772 xref: GO:0017066 xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0001133 name: steryl-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + SO4(2-) (sulfate)." [EC:3.1.6.2] synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "arylsulfatase C activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "phenolic steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "pregnenolone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid 3-sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "sterol sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulphatase activity" EXACT [] xref: EC:3.1.6.2 xref: GO:0004773 xref: MetaCyc:STERYL-SULFATASE-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0001134 name: succinate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction between succinate and CoA to form succinyl-CoA." [EC:6.2.1.-, GOC:ai] subset: gosubset_prok xref: EC:6.2.1.- xref: GO:0004774 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0001135 name: succinate-CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5] subset: gosubset_prok synonym: "A-SCS" RELATED [EC:6.2.1.5] synonym: "A-STK (adenin nucleotide-linked succinate thiokinase)" RELATED [EC:6.2.1.5] synonym: "succinate thiokinase activity" EXACT [EC:6.2.1.5] synonym: "succinate:CoA ligase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinic thiokinase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase activity" EXACT [EC:6.2.1.5] xref: EC:6.2.1.5 xref: GO:0004775 xref: MetaCyc:SUCCCOASYN-RXN xref: Reactome:14321 is_a: CCO:F0001134 ! succinate-CoA ligase activity [Term] id: CCO:F0001136 name: succinate-CoA ligase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4] subset: gosubset_prok synonym: "G-STK" RELATED [EC:6.2.1.4] synonym: "P-enzyme" RELATED [EC:6.2.1.4] synonym: "SCS" RELATED [EC:6.2.1.4] synonym: "succinate-phosphorylating enzyme" RELATED [EC:6.2.1.4] synonym: "succinate:CoA ligase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinic thiokinase" BROAD [EC:6.2.1.4] synonym: "succinyl CoA synthetase activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] xref: EC:6.2.1.4 xref: GO:0004776 xref: MetaCyc:SUCCINATE--COA-LIGASE-(GDP-FORMING)-RXN xref: Reactome:14322 is_a: CCO:F0001134 ! succinate-CoA ligase activity [Term] id: CCO:F0001137 name: succinate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24] subset: gosubset_prok synonym: "succinate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] xref: EC:1.2.1.24 xref: GO:0004777 xref: GO:0008952 xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001138 name: succinyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + H2O = CoA + succinate." [EC:3.1.2.3] synonym: "succinyl coenzyme A deacylase activity" EXACT [EC:3.1.2.3] synonym: "succinyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.3] synonym: "succinyl-CoA acylase activity" EXACT [EC:3.1.2.3] xref: EC:3.1.2.3 xref: GO:0004778 xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0001139 name: sulfate adenylyltransferase activity namespace: molecular_function subset: gosubset_prok synonym: "sulphate adenylyltransferase activity" EXACT [] xref: EC:2.7.7.- xref: GO:0004779 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0001140 name: sulfate adenylyltransferase (ADP) activity namespace: molecular_function def: "Catalysis of the reaction: ADP + SO4(2-) (sulfate) = phosphate + adenylylsulfate." [EC:2.7.7.5] synonym: "adenosine diphosphate sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP-sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" EXACT [EC:2.7.7.5] synonym: "sulphate adenylyltransferase (ADP) activity" EXACT [] xref: EC:2.7.7.5 xref: GO:0004780 xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-(ADP)-RXN is_a: CCO:F0001139 ! sulfate adenylyltransferase activity [Term] id: CCO:F0001141 name: sulfate adenylyltransferase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + SO4(2-) (sulfate) = diphosphate + adenylylsulfate." [EC:2.7.7.4] subset: gosubset_prok synonym: "adenosine-5'-triphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenosinetriphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenylylsulfate pyrophosphorylase activity" EXACT [EC:2.7.7.4] synonym: "ATP sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP-sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate adenylate transferase activity" EXACT [EC:2.7.7.4] synonym: "sulfurylase activity" RELATED [EC:2.7.7.4] synonym: "sulphate adenylyltransferase (ATP) activity" EXACT [] xref: EC:2.7.7.4 xref: GO:0004781 xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN xref: Reactome:14341 is_a: CCO:F0001139 ! sulfate adenylyltransferase activity [Term] id: CCO:F0001142 name: sulfinoalanine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" EXACT [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase activity" EXACT [EC:4.1.1.29] synonym: "CADCase/CSADCase activity" EXACT [EC:4.1.1.29] synonym: "CSAD" RELATED [EC:4.1.1.29] synonym: "CSADCase activity" EXACT [EC:4.1.1.29] synonym: "cysteic decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteine-sulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "L-cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulphinoalanine decarboxylase activity" EXACT [] xref: EC:4.1.1.29 xref: GO:0004782 xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0001143 name: sulfite reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: H2S + 3 NADP+ + 3 H2O = SO3(2-) (sulfite) + 3 NADPH + 3 H+." [EC:1.8.1.2] subset: gosubset_prok synonym: "H2S-NADP oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-dependent sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH:sulfite reductase flavoprotein" RELATED [] synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.8.1.2] synonym: "sulphite reductase (NADPH) activity" EXACT [] xref: EC:1.8.1.2 xref: GO:0004783 xref: MetaCyc:SULFITE-REDUCT-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001144 name: superoxide dismutase activity namespace: molecular_function def: "Catalysis of the reaction: 2 peroxide radical + 2 H+ = O2 + H2O2." [EC:1.15.1.1] subset: gosubset_prok synonym: "copper, zinc superoxide dismutase activity" NARROW [] synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1] synonym: "Cu-Zn superoxide dismutase activity activity" NARROW [EC:1.15.1.1] synonym: "cuprein" RELATED [EC:1.15.1.1] synonym: "cytocuprein" RELATED [EC:1.15.1.1] synonym: "erythrocuprein" RELATED [EC:1.15.1.1] synonym: "Fe-SOD" RELATED [EC:1.15.1.1] synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "hemocuprein" RELATED [EC:1.15.1.1] synonym: "hepatocuprein" RELATED [EC:1.15.1.1] synonym: "iron superoxide dismutase activity" NARROW [] synonym: "iron superoxide oxidoreductase" RELATED [] synonym: "manganese superoxide dismutase activity" NARROW [] synonym: "manganese superoxide oxidoreductase" RELATED [] synonym: "Mn, Fe superoxide dismutase" NARROW [] synonym: "Mn-SOD" RELATED [EC:1.15.1.1] synonym: "nickel superoxide dismutase activity" NARROW [] synonym: "nickel superoxide oxidoreductase" RELATED [] synonym: "SOD" RELATED [EC:1.15.1.1] synonym: "SOD-1" RELATED [EC:1.15.1.1] synonym: "SOD-2" RELATED [EC:1.15.1.1] synonym: "SOD-3" RELATED [EC:1.15.1.1] synonym: "SOD-4" RELATED [EC:1.15.1.1] synonym: "SODF" RELATED [EC:1.15.1.1] synonym: "SODS" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1] synonym: "superoxide:superoxide oxidoreductase activity" EXACT [] synonym: "zinc superoxide oxidoreductase" RELATED [] xref: EC:1.15.1.1 xref: GO:0004784 xref: GO:0004785 xref: GO:0008382 xref: GO:0008383 xref: GO:0016954 xref: MetaCyc:SUPEROX-DISMUT-RXN is_a: CCO:F0003303 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: CCO:F0001145 name: thiamin-pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: TDP + H2O = TMP + phosphate." [EC:3.6.1.-, GOC:ai] synonym: "thiamin pyrophosphatase activity" EXACT [] synonym: "thiamine pyrophosphatase activity" EXACT [] synonym: "thiaminpyrophosphatase activity" EXACT [EC:3.6.1.6] synonym: "TPPase activity" EXACT [] xref: EC:3.6.1.- xref: GO:0004787 is_a: CCO:F0003573 ! nucleoside-diphosphatase activity [Term] id: CCO:F0001146 name: thiamin diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamin = AMP + thiamin diphosphate." [EC:2.7.6.2] subset: gosubset_prok synonym: "ATP:thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "ATP:thiamine diphosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin pyrophosphokinase activity" EXACT [] synonym: "thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin:ATP pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamine diphosphokinase activity" EXACT [EC:2.7.6.2] synonym: "thiamine pyrophosphokinase activity" EXACT [] synonym: "thiaminokinase activity" EXACT [EC:2.7.6.2] synonym: "TPTase activity" EXACT [EC:2.7.6.2] xref: EC:2.7.6.2 xref: GO:0004788 xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003350 ! diphosphotransferase activity [Term] id: CCO:F0001147 name: thiamin-phosphate diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamin monophosphate." [EC:2.5.1.3] subset: gosubset_prok synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.3] synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine monophosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine phosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine-phosphate diphosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine-phosphate synthase activity" EXACT [EC:2.5.1.3] synonym: "TMP diphosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP-PPase activity" EXACT [EC:2.5.1.3] xref: EC:2.5.1.3 xref: GO:0004789 xref: MetaCyc:THI-P-SYN-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0001148 name: thioether S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96] synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "thioether methyltransferase activity" EXACT [EC:2.1.1.96] xref: EC:2.1.1.96 xref: GO:0004790 xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN is_a: CCO:F0001759 ! S-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0001149 name: thioredoxin-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+." [EC:1.8.1.9, ISBN:0198547684] subset: gosubset_prok synonym: "NADP--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "thioredoxin disulfide reductase activity" EXACT [] synonym: "thioredoxin reductase (NADPH) activity" EXACT [] synonym: "thioredoxin-disulphide reductase activity" EXACT [] synonym: "thioredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.9] xref: EC:1.8.1.9 xref: GO:0004791 xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN xref: Reactome:14367 is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003069 ! antioxidant activity is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001150 name: thiosulfate sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: thiosulfate + cyanide = SO3(2-) (sulfite) + thiocyanate." [EC:2.8.1.1] subset: gosubset_prok synonym: "rhodanase activity" EXACT [EC:2.8.1.1] synonym: "rhodanese activity" RELATED [EC:2.8.1.1] synonym: "thiosulfate cyanide transsulfurase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate thiotransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulphate sulphurtransferase activity" EXACT [] xref: EC:2.8.1.1 xref: GO:0004792 xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN is_a: CCO:F0003355 ! sulfurtransferase activity [Term] id: CCO:F0001151 name: threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5] subset: gosubset_prok synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.5] synonym: "L-threonine acetaldehyde-lyase activity" EXACT [EC:4.1.2.5] synonym: "L-threonine aldolase activity" EXACT [] xref: EC:4.1.2.5 xref: GO:0004793 xref: MetaCyc:THREONINE-ALDOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0001152 name: L-threonine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19] comment: Note that this function was formerly EC:4.2.1.16. subset: gosubset_prok synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19] synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19] synonym: "L-threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine dehydratase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.19] synonym: "serine deaminase activity" RELATED [EC:4.3.1.19] synonym: "threonine ammonia-lyase activity" EXACT [] synonym: "threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydrase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydratase activity" EXACT [] xref: EC:4.3.1.19 xref: GO:0004794 xref: MetaCyc:THREDEHYD-RXN xref: UM-BBD_enzymeID:e0306 is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0001153 name: threonine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1] subset: gosubset_prok synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" EXACT [EC:4.2.3.1] synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" EXACT [EC:4.2.3.1] synonym: "threonine synthetase activity" EXACT [EC:4.2.3.1] xref: EC:4.2.3.1 xref: GO:0004795 xref: MetaCyc:THRESYN-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0001154 name: thromboxane-A synthase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromba-5,13-dienoate." [EC:5.3.99.5] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" EXACT [EC:5.3.99.5] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" EXACT [EC:5.3.99.5] synonym: "cytochrome P450 CYP5" NARROW [] synonym: "thromboxane synthase activity" EXACT [EC:5.3.99.5] synonym: "thromboxane synthetase activity" EXACT [EC:5.3.99.5] xref: EC:5.3.99.5 xref: GO:0004796 xref: GO:0008400 xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN xref: Reactome:14373 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0001155 name: thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21] subset: gosubset_prok synonym: "2'-deoxythymidine kinase activity" EXACT [EC:2.7.1.21] synonym: "ATP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.21] synonym: "deoxythymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] synonym: "thymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] xref: EC:2.7.1.21 xref: GO:0004797 xref: MetaCyc:THYKI-RXN is_a: CCO:F0004072 ! deoxynucleoside kinase activity [Term] id: CCO:F0001156 name: thymidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9] subset: gosubset_prok synonym: "ATP:dTMP phosphotransferase activity" EXACT [EC:2.7.4.9] synonym: "deoxythymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "dTMP kinase activity" EXACT [] synonym: "thymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidine monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylate monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic acid kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic kinase activity" EXACT [EC:2.7.4.9] synonym: "TMPK activity" EXACT [EC:2.7.4.9] xref: EC:2.7.4.9 xref: GO:0004798 xref: MetaCyc:DTMPKI-RXN is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor is_a: CCO:F0004124 ! nucleotide kinase activity [Term] id: CCO:F0001157 name: thymidylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "dTMP synthase activity" EXACT [EC:2.1.1.45] synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "thymidylate synthetase activity" EXACT [EC:2.1.1.45] synonym: "TMP synthetase activity" EXACT [EC:2.1.1.45] xref: EC:2.1.1.45 xref: GO:0004799 xref: MetaCyc:THYMIDYLATESYN-RXN xref: Reactome:14376 is_a: CCO:F0005619 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: CCO:F0001158 name: thyroxine 5'-deiodinase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.97.1.10] comment: Note that this was EC:3.8.1.4. synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" EXACT [EC:1.97.1.10] synonym: "diiodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] synonym: "iodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] synonym: "iodothyronine outer ring monodeiodinase activity" EXACT [EC:1.97.1.10] synonym: "L-thyroxine iodohydrolase (reducing) activity" EXACT [EC:1.97.1.10] synonym: "thyroxine 5' deiodinase activity" EXACT [] synonym: "thyroxine deiodinase activity" BROAD [] synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] xref: EC:1.97.1.10 xref: GO:0004800 xref: MetaCyc:THYROXINE-DEIODINASE-RXN is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0001159 name: transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2] subset: gosubset_prok synonym: "dihydroxyacetone transferase activity" EXACT [EC:2.2.1.2] synonym: "dihydroxyacetonetransferase activity" EXACT [EC:2.2.1.2] synonym: "glycerone transferase activity" EXACT [EC:2.2.1.2] synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity" EXACT [EC:2.2.1.2] xref: EC:2.2.1.2 xref: GO:0004801 xref: MetaCyc:TRANSALDOL-RXN xref: Reactome:15049 is_a: CCO:F0003320 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: CCO:F0001160 name: transketolase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate." [EC:2.2.1.1] subset: gosubset_prok synonym: "glycoaldehyde transferase activity" EXACT [EC:2.2.1.1] synonym: "glycolaldehydetransferase activity" EXACT [EC:2.2.1.1] synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" EXACT [EC:2.2.1.1] xref: EC:2.2.1.1 xref: GO:0004802 xref: MetaCyc:1TRANSKETO-RXN xref: Reactome:15050 is_a: CCO:F0003320 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: CCO:F0001161 name: transposase activity namespace: molecular_function def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in site-specific DNA recombination required for transposition in bacteria and other organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok xref: GO:0004803 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0001162 name: P-element encoded transposase activity namespace: molecular_function xref: GO:0004804 is_a: CCO:F0001161 ! transposase activity [Term] id: CCO:F0001163 name: trehalose-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12] subset: gosubset_prok synonym: "trehalose 6-phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose phosphatase activity" EXACT [] synonym: "trehalose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.12] xref: EC:3.1.3.12 xref: GO:0004805 xref: MetaCyc:TREHALOSEPHOSPHA-RXN is_a: CCO:F0004126 ! carbohydrate phosphatase activity [Term] id: CCO:F0001164 name: triacylglycerol lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion." [EC:3.1.1.3] subset: gosubset_prok synonym: "amano AP" RELATED [EC:3.1.1.3] synonym: "amano B" RELATED [EC:3.1.1.3] synonym: "amano CE" RELATED [EC:3.1.1.3] synonym: "amano CES" RELATED [EC:3.1.1.3] synonym: "amano P" RELATED [EC:3.1.1.3] synonym: "amno N-AP" RELATED [EC:3.1.1.3] synonym: "butyrinase activity" EXACT [EC:3.1.1.3] synonym: "cacordase activity" EXACT [EC:3.1.1.3] synonym: "capalase L" RELATED [EC:3.1.1.3] synonym: "GA 56" RELATED [EC:3.1.1.3] synonym: "GEH" RELATED [EC:3.1.1.3] synonym: "glycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "glycerol-ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3] synonym: "lipazin" RELATED [EC:3.1.1.3] synonym: "liver lipase" NARROW [EC:3.1.1.3] synonym: "meito MY 30" RELATED [EC:3.1.1.3] synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3] synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3] synonym: "PPL" RELATED [EC:3.1.1.3] synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3] synonym: "steapsin" RELATED [EC:3.1.1.3] synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3] synonym: "triacetinase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tributyrase activity" RELATED [EC:3.1.1.3] synonym: "tributyrin esterase activity" EXACT [EC:3.1.1.3] synonym: "tributyrinase activity" EXACT [EC:3.1.1.3] synonym: "triglyceridase activity" EXACT [EC:3.1.1.3] synonym: "triglyceride hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triglyceride lipase activity" EXACT [EC:3.1.1.3] synonym: "triolein hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween-hydrolyzing esterase activity" EXACT [EC:3.1.1.3] synonym: "tweenase activity" EXACT [EC:3.1.1.3] synonym: "tweenesterase activity" EXACT [EC:3.1.1.3] xref: EC:3.1.1.3 xref: GO:0004806 xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN xref: Reactome:15058 is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0003111 ! lipase activity [Term] id: CCO:F0001165 name: triose-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1] subset: gosubset_prok synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.1] synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.1] synonym: "phosphotriose isomerase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphate mutase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphoisomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate isomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate mutase activity" EXACT [EC:5.3.1.1] xref: EC:5.3.1.1 xref: GO:0004807 xref: MetaCyc:TRIOSEPISOMERIZATION-RXN xref: Reactome:70450 is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0001166 name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" EXACT [EC:2.1.1.61] xref: EC:2.1.1.61 xref: GO:0004808 xref: GO:0016425 xref: MetaCyc:2.1.1.61-RXN is_a: CCO:F0001762 ! tRNA methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0001167 name: tRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32] subset: gosubset_prok synonym: "guanine-N2-methylase activity" EXACT [EC:2.1.1.32] synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine N2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer RNA guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA 2,2-dimethylguanosine-26 methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N2-N2) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(m(2,2)G26)dimethyltransferase activity" EXACT [EC:2.1.1.32] xref: EC:2.1.1.32 xref: GO:0004809 xref: MetaCyc:TRNA-(GUANINE-N2-)-METHYLTRANSFERASE-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0003146 ! tRNA (guanine) methyltransferase activity [Term] id: CCO:F0001168 name: tRNA adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.25] subset: gosubset_prok synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP:tRNA adenylyltransferase activity" EXACT [] synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.25] synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate adenyltransferase activity" EXACT [EC:2.7.7.25] synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.25] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.25] xref: EC:2.7.7.25 xref: GO:0004810 xref: MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0001169 name: tRNA isopentenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine." [EC:2.5.1.8] subset: gosubset_prok synonym: "delta2-isopentenyl pyrophosphate:transfer ribonucleic acid delta2-isopentenyltransferase activity" EXACT [EC:2.5.1.8] synonym: "delta2-isopentenyl pyrophosphate:tRNA-delta2-isopentenyl transferase activity" EXACT [EC:2.5.1.8] synonym: "IPP transferase activity" EXACT [EC:2.5.1.8] synonym: "isopentenyl-diphosphate:tRNA isopentenyltransferase activity" EXACT [EC:2.5.1.8] synonym: "transfer ribonucleate isopentenyltransferase activity" EXACT [EC:2.5.1.8] xref: EC:2.5.1.8 xref: GO:0004811 xref: MetaCyc:TRNA-ISOPENTENYLTRANSFERASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0001170 name: aminoacyl-tRNA ligase activity namespace: molecular_function def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that the bond resulting from this reaction is an carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA. subset: gosubset_prok synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd] xref: EC:6.1.1.- xref: GO:0004812 is_a: CCO:F0003435 ! ligase activity, forming aminoacyl-tRNA and related compounds [Term] id: CCO:F0001171 name: alanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7] subset: gosubset_prok synonym: "Ala-tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine translase activity" EXACT [EC:6.1.1.7] synonym: "alanine tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine-transfer RNA ligase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-tRNA synthetase activity" EXACT [] synonym: "AlaRS" RELATED [EC:6.1.1.7] synonym: "L-alanine:tRNAAla ligase (AMP-forming)" EXACT [EC:6.1.1.7] xref: EC:6.1.1.7 xref: GO:0004813 xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001172 name: arginine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19] subset: gosubset_prok synonym: "arginine translase activity" EXACT [EC:6.1.1.19] synonym: "arginine-tRNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-tRNA synthetase activity" EXACT [] synonym: "L-arginine:tRNAArg ligase (AMP-forming)" EXACT [EC:6.1.1.19] xref: EC:6.1.1.19 xref: GO:0004814 xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001173 name: aspartate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12] subset: gosubset_prok synonym: "aspartic acid translase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleate synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleic synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-tRNA synthetase activity" EXACT [] synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" EXACT [EC:6.1.1.12] xref: EC:6.1.1.12 xref: GO:0004815 xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001174 name: asparagine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)." [EC:6.1.1.22] subset: gosubset_prok synonym: "asparagine translase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-tRNA synthetase activity" EXACT [] synonym: "asparagyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" EXACT [EC:6.1.1.22] xref: EC:6.1.1.22 xref: GO:0004816 xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001175 name: cysteine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16] subset: gosubset_prok synonym: "cysteine translase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transferRNA synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-tRNA synthetase activity" EXACT [] synonym: "L-cysteine:tRNACys ligase (AMP-forming)" EXACT [EC:6.1.1.16] xref: EC:6.1.1.16 xref: GO:0004817 xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001176 name: glutamate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] subset: gosubset_prok synonym: "glutamate-tRNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamic acid translase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" EXACT [EC:6.1.1.17] xref: EC:6.1.1.17 xref: GO:0004818 xref: MetaCyc:GLURS-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001177 name: glutamine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18] subset: gosubset_prok synonym: "GlnRS" RELATED [EC:6.1.1.18] synonym: "glutamine translase activity" EXACT [EC:6.1.1.18] synonym: "glutamine-tRNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18] synonym: "glutaminyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" EXACT [EC:6.1.1.18] xref: EC:6.1.1.18 xref: GO:0004819 xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001178 name: glycine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14] subset: gosubset_prok synonym: "glycine:tRNAGly ligase (AMP-forming) activity" EXACT [EC:6.1.1.14] synonym: "glycyl translase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.14 xref: GO:0004820 xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001179 name: histidine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21] subset: gosubset_prok synonym: "histidine translase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-tRNA synthetase activity" EXACT [] synonym: "L-histidine:tRNAHis ligase (AMP-forming)" EXACT [EC:6.1.1.21] xref: EC:6.1.1.21 xref: GO:0004821 xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001180 name: isoleucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)." [EC:6.1.1.5] subset: gosubset_prok synonym: "isoleucine translase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-transfer RNA ligase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-tRNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-tRNA synthetase activity" EXACT [] synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [EC:6.1.1.5] xref: EC:6.1.1.5 xref: GO:0004822 xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001181 name: leucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)." [EC:6.1.1.4] subset: gosubset_prok synonym: "L-leucine:tRNALeu ligase (AMP-forming)" EXACT [EC:6.1.1.4] synonym: "leucine translase activity" EXACT [EC:6.1.1.4] synonym: "leucine-tRNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.4 xref: GO:0004823 xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001182 name: lysine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6] subset: gosubset_prok synonym: "L-lysine-transfer RNA ligase activity" EXACT [EC:6.1.1.6] synonym: "L-lysine:tRNALys ligase (AMP-forming)" EXACT [EC:6.1.1.6] synonym: "lysine translase activity" EXACT [EC:6.1.1.6] synonym: "lysine-tRNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.6 xref: GO:0004824 xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001183 name: methionine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10] subset: gosubset_prok synonym: "L-methionine:tRNAMet ligase (AMP-forming)" EXACT [EC:6.1.1.10] synonym: "methionine translase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-tRNA synthetase activity" EXACT [] synonym: "MetRS activity" EXACT [EC:6.1.1.10] xref: EC:6.1.1.10 xref: GO:0004825 xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001184 name: phenylalanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] subset: gosubset_prok synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" EXACT [EC:6.1.1.20] synonym: "L-phenylalanyl-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine translase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.20 xref: GO:0004826 xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001185 name: proline-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15] subset: gosubset_prok synonym: "L-proline:tRNAPro ligase (AMP-forming)" EXACT [EC:6.1.1.15] synonym: "proline translase activity" EXACT [EC:6.1.1.15] synonym: "prolinyl-tRNA ligase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-s-RNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transferRNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.15 xref: GO:0004827 xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001186 name: serine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] subset: gosubset_prok synonym: "L-serine:tRNASer ligase (AMP-forming)" EXACT [EC:6.1.1.11] synonym: "serine translase activity" EXACT [EC:6.1.1.11] synonym: "SerRS activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer RNA synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.11 xref: GO:0004828 xref: MetaCyc:SERINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001187 name: threonine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3] subset: gosubset_prok synonym: "L-threonine:tRNAThr ligase (AMP-forming)" EXACT [EC:6.1.1.3] synonym: "threonine translase activity" EXACT [EC:6.1.1.3] synonym: "threonine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl ribonucleic synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-tRNA synthetase activity" EXACT [] synonym: "TRS" RELATED [EC:6.1.1.3] xref: EC:6.1.1.3 xref: GO:0004829 xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001188 name: tryptophan-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] subset: gosubset_prok synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" EXACT [EC:6.1.1.2] synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "TrpRS activity" EXACT [EC:6.1.1.2] synonym: "tryptophan translase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.2 xref: GO:0004830 xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001189 name: tyrosine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)." [EC:6.1.1.1] subset: gosubset_prok synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" EXACT [EC:6.1.1.1] synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "tyrosine translase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine tRNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer RNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.1 xref: GO:0004831 xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001190 name: valine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)." [EC:6.1.1.9] subset: gosubset_prok synonym: "L-valine:tRNAVal ligase (AMP-forming)" EXACT [EC:6.1.1.9] synonym: "valine transfer ribonucleate ligase activity" EXACT [EC:6.1.1.9] synonym: "valine translase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.9 xref: GO:0004832 xref: MetaCyc:VALINE--TRNA-LIGASE-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0001191 name: tryptophan 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11] subset: gosubset_prok synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11] synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT [] synonym: "L-tryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan pyrrolase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.11] synonym: "TDO" RELATED [EC:1.13.11.11] synonym: "tryptamin 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptamine 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11] xref: EC:1.13.11.11 xref: GO:0004426 xref: GO:0004833 xref: MetaCyc:INDOLEAMINE-PYRROLE-2 xref: MetaCyc:TRYPTOPHAN-2 xref: Reactome:15133 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0001192 name: tryptophan synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [EC:4.2.1.20] subset: gosubset_prok synonym: "indoleglycerol phosphate aldolase activity" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20] synonym: "L-tryptophan synthetase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan desmolase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan synthetase activity" EXACT [EC:4.2.1.20] xref: EC:4.2.1.20 xref: GO:0004834 xref: MetaCyc:TRYPSYN-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0001193 name: tubulin-tyrosine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" EXACT [EC:6.3.2.25] synonym: "TTL activity" EXACT [EC:6.3.2.25] synonym: "tubulinyl-tyrosine ligase activity" EXACT [] xref: EC:6.3.2.25 xref: GO:0004835 xref: MetaCyc:6.3.2.25-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0001194 name: tyramine-beta hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161] xref: GO:0004836 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0001195 name: tyrosine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25] synonym: "L-(-)-tyrosine apodecarboxylase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine decarboxylase activity" EXACT [EC:4.1.1.25] xref: EC:4.1.1.25 xref: GO:0004837 xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0001196 name: tyrosine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5] subset: gosubset_prok synonym: "glutamic phenylpyruvic aminotransferase activity" EXACT [EC:2.6.1.5] synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" EXACT [EC:2.6.1.5] synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.5] synonym: "L-tyrosine aminotransferase activity" EXACT [EC:2.6.1.5] synonym: "L-tyrosine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.5] synonym: "phenylalanine aminotransferase activity" EXACT [EC:2.6.1.5] synonym: "phenylalanine transaminase activity" EXACT [EC:2.6.1.5] synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.5] synonym: "phenylpyruvate transaminase activity" EXACT [EC:2.6.1.5] synonym: "phenylpyruvic acid transaminase activity" EXACT [EC:2.6.1.5] synonym: "TyrAT activity" EXACT [EC:2.6.1.5] synonym: "tyrosine aminotransferase activity" EXACT [] synonym: "tyrosine-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.5] xref: EC:2.6.1.5 xref: GO:0004838 xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN xref: Reactome:15141 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0001197 name: ubiquitin activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner." [http://www.bostonbiochem.com/E-301.html, PMID:10072378] synonym: "E1" EXACT [] xref: GO:0004839 is_a: CCO:F0002013 ! small protein activating enzyme activity [Term] id: CCO:F0001198 name: ubiquitin-protein ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407] subset: gosubset_prok synonym: "E2" NARROW [] synonym: "E3" NARROW [] synonym: "ubiquitin activity" RELATED [EC:6.3.2.19] synonym: "ubiquitin conjugating enzyme activity" EXACT [] synonym: "ubiquitin ligase activity" EXACT [] synonym: "ubiquitin protein ligase activity" EXACT [] synonym: "ubiquitin protein-ligase activity" EXACT [] synonym: "ubiquitin-activating enzyme" EXACT [] synonym: "ubiquitin-conjugating enzyme activity" EXACT [] synonym: "ubiquitin-ligase activity" EXACT [] synonym: "ubiquitin:protein-lysine N-ligase (AMP-forming) activity" EXACT [EC:6.3.2.19] xref: EC:6.3.2.19 xref: GO:0004840 xref: GO:0004841 xref: GO:0004842 xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN xref: Reactome:15168 xref: Reactome:15171 is_a: CCO:F0004170 ! small conjugating protein ligase activity [Term] id: CCO:F0001199 name: ubiquitin-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups." [ISBN:0120793709] subset: gosubset_prok synonym: "UBP" NARROW [] synonym: "UCH2" NARROW [] xref: GO:0004843 is_a: CCO:F0004166 ! small conjugating protein-specific protease activity [Term] id: CCO:F0001200 name: uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, PMID:9224623] subset: gosubset_prok synonym: "uracil-DNA glycosylase activity" EXACT [] xref: EC:3.2.2.- xref: GO:0004844 xref: Reactome:15174 is_a: CCO:F0004051 ! DNA N-glycosylase activity [Term] id: CCO:F0001201 name: uracil phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.9] subset: gosubset_prok synonym: "UMP diphosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UPRTase activity" EXACT [EC:2.4.2.9] synonym: "uridine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylic pyrophosphorylase activity" EXACT [EC:2.4.2.9] xref: EC:2.4.2.9 xref: GO:0004845 xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN xref: Reactome:15175 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0001202 name: urate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2." [EC:1.7.3.3] subset: gosubset_prok synonym: "urate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.3] synonym: "uric acid oxidase activity" EXACT [EC:1.7.3.3] synonym: "uricase activity" EXACT [EC:1.7.3.3] synonym: "uricase II activity" NARROW [EC:1.7.3.3] xref: EC:1.7.3.3 xref: GO:0004846 xref: MetaCyc:URATE-OXIDASE-RXN is_a: CCO:F0003258 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: CCO:F0001203 name: urea carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + urea + CO2 = ADP + phosphate + urea-1-carboxylate." [EC:6.3.4.6] subset: gosubset_prok synonym: "ATP--urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "UALase activity" EXACT [EC:6.3.4.6] synonym: "UCA activity" EXACT [EC:6.3.4.6] synonym: "urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolyzing) activity" EXACT [EC:6.3.4.6] synonym: "urea:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolyzing) activity" EXACT [EC:6.3.4.6] xref: EC:6.3.4.6 xref: GO:0004847 xref: MetaCyc:UREA-CARBOXYLASE-RXN is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0001204 name: ureidoglycolate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2." [EC:3.5.3.19] subset: gosubset_prok synonym: "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [EC:3.5.3.19] xref: EC:3.5.3.19 xref: GO:0004848 xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0001205 name: uridine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48] subset: gosubset_prok synonym: "ATP:uridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.48] synonym: "pyrimidine ribonucleoside kinase activity" EXACT [EC:2.7.1.48] synonym: "uridine kinase (phosphorylating)" EXACT [EC:2.7.1.48] synonym: "uridine kinase reaction" EXACT [] synonym: "uridine monophosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine phosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine-cytidine kinase activity" EXACT [EC:2.7.1.48] xref: EC:2.7.1.48 xref: GO:0004849 xref: MetaCyc:URIDINEKIN-RXN is_a: CCO:F0004129 ! nucleoside kinase activity [Term] id: CCO:F0001206 name: uridine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3] subset: gosubset_prok synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3] synonym: "UPase activity" EXACT [EC:2.4.2.3] synonym: "UPH" RELATED [EC:2.4.2.3] synonym: "UrdPase activity" EXACT [EC:2.4.2.3] synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.3] xref: EC:2.4.2.3 xref: GO:0004850 xref: MetaCyc:URPHOS-RXN xref: Reactome:15196 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0001207 name: uroporphyrin-III C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107] subset: gosubset_prok synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "CobA" RELATED [EC:2.1.1.107] synonym: "CysG" RELATED [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "SirA" RELATED [EC:2.1.1.107] synonym: "SUMT activity" EXACT [EC:2.1.1.107] synonym: "urogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107] xref: EC:2.1.1.107 xref: GO:0004851 xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN is_a: CCO:F0001756 ! C-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0001208 name: uroporphyrinogen-III synthase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylbilane = uroporphyrinogen-III + H2O." [EC:4.2.1.75] subset: gosubset_prok synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" EXACT [EC:4.2.1.75] synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" EXACT [EC:4.2.1.75] synonym: "porphobilinogenase activity" EXACT [EC:4.2.1.75] synonym: "URO-synthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen isomerase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthetase activity" EXACT [EC:4.2.1.75] xref: EC:4.2.1.75 xref: GO:0004852 xref: MetaCyc:UROGENIIISYN-RXN xref: Reactome:15200 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0001209 name: uroporphyrinogen decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37] subset: gosubset_prok synonym: "porphyrinogen carboxy-lyase activity" EXACT [EC:4.1.1.37] synonym: "porphyrinogen decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen III decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase activity" EXACT [EC:4.1.1.37] xref: EC:4.1.1.37 xref: GO:0004853 xref: MetaCyc:UROGENDECARBOX-RXN xref: Reactome:15202 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0001210 name: xanthine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4] subset: gosubset_prok synonym: "NAD-xanthine dehydrogenase activity" EXACT [EC:1.17.1.4] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4] synonym: "xanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] xref: EC:1.17.1.4 xref: GO:0004854 xref: MetaCyc:XANTHINE-DEHYDROGENASE-RXN is_a: CCO:F0003308 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: CCO:F0001211 name: xanthine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + H2O2." [EC:1.17.3.2] subset: gosubset_prok synonym: "hypoxanthine oxidase activity" EXACT [EC:1.17.3.2] synonym: "hypoxanthine-xanthine oxidase activity" EXACT [EC:1.17.3.2] synonym: "hypoxanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] synonym: "Schardinger enzyme activity" EXACT [EC:1.17.3.2] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] synonym: "xanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:xanthine oxidase activity" EXACT [EC:1.17.3.2] xref: EC:1.17.3.2 xref: GO:0004855 xref: MetaCyc:XANTHINE-OXIDASE-RXN xref: Reactome:15204 is_a: CCO:F0003309 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: CCO:F0001212 name: xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-xylulose = ADP + D-xylulose 5-phosphate." [EC:2.7.1.17] subset: gosubset_prok synonym: "ATP:D-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.17] synonym: "D-xylulokinase activity" EXACT [EC:2.7.1.17] synonym: "xylulokinase (phosphorylating)" EXACT [EC:2.7.1.17] synonym: "xylulose kinase activity" EXACT [EC:2.7.1.17] xref: EC:2.7.1.17 xref: GO:0004856 xref: MetaCyc:XYLULOKIN-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0001213 name: enzyme inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an enzyme." [GOC:ai] subset: gosubset_prok xref: GO:0004857 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0001214 name: dUTP pyrophosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah] xref: GO:0004858 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0001215 name: phospholipase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl] xref: GO:0004859 is_a: CCO:F0008232 ! lipase inhibitor activity [Term] id: CCO:F0001216 name: protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] subset: gosubset_prok xref: GO:0004860 is_a: CCO:F0004133 ! kinase inhibitor activity is_a: CCO:F0004204 ! protein kinase regulator activity [Term] id: CCO:F0001217 name: cyclin-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cyclin-dependent protein kinase." [GOC:mah] synonym: "CDK inhibitor" RELATED [] synonym: "cyclin dependent kinase inhibitor" RELATED [] synonym: "cyclin dependent protein kinase inhibitor activity" EXACT [] synonym: "cyclin-dependent kinase inhibitor" RELATED [] xref: GO:0004861 xref: Reactome:15226 is_a: CCO:F0004378 ! protein serine/threonine kinase inhibitor activity [Term] id: CCO:F0001218 name: cAMP-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah] xref: GO:0004862 is_a: CCO:F0004378 ! protein serine/threonine kinase inhibitor activity [Term] id: CCO:F0001219 name: diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity namespace: molecular_function synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT [] xref: GO:0004863 is_a: CCO:F0001893 ! protein kinase C inhibitor activity [Term] id: CCO:F0001220 name: protein phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from proteins." [GOC:ai] xref: GO:0004864 is_a: CCO:F0004135 ! phosphatase inhibitor activity [Term] id: CCO:F0001221 name: type 1 serine/threonine specific protein phosphatase inhibitor activity namespace: molecular_function xref: GO:0004865 is_a: CCO:F0001220 ! protein phosphatase inhibitor activity [Term] id: CCO:F0001222 name: endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides." [GOC:jl] subset: gosubset_prok synonym: "alpha-2 macroglobulin" RELATED [] synonym: "endoproteinase inhibitor" EXACT [] synonym: "proteinase inhibitor" BROAD [] xref: GO:0004866 is_a: CCO:F0004441 ! protease inhibitor activity [Term] id: CCO:F0001223 name: serine-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] subset: gosubset_prok synonym: "serine protease inhibitor activity" EXACT [] synonym: "serine proteinase inhibitor activity" EXACT [] synonym: "serpin activity" NARROW [] xref: GO:0004867 xref: Reactome:15233 is_a: CCO:F0001222 ! endopeptidase inhibitor activity [Term] id: CCO:F0001224 name: cysteine protease inhibitor activity namespace: molecular_function subset: gosubset_prok synonym: "thiol protease inhibitor" EXACT [] xref: GO:0004869 xref: GO:0004870 is_a: CCO:F0001222 ! endopeptidase inhibitor activity [Term] id: CCO:F0001225 name: signal transducer activity namespace: molecular_function def: "Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0004871 is_a: CCO:F0008240 ! molecular transducer activity [Term] id: CCO:F0001226 name: receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: gosubset_prok synonym: "receptor guanylate cyclase activity" NARROW [] xref: GO:0004872 is_a: CCO:F0001225 ! signal transducer activity [Term] id: CCO:F0001227 name: asialoglycoprotein receptor activity namespace: molecular_function def: "The mediation of the endocytosis of plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate moieties has been removed; recognizes the terminal galactose and N-acetylgalactosamine units; the complex of receptor and ligand is internalized and transported to a sorting organelle where disassociation occurs, the receptor being recycled to the cell membrane." [UniProtKB:P24721] xref: GO:0004873 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001228 name: aryl hydrocarbon receptor activity namespace: molecular_function def: "Combining with an aryl hydrocarbon to initiate a change in cell activity." [GOC:ai] xref: GO:0004874 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0001229 name: complement receptor activity namespace: molecular_function def: "Combining with any component or product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. xref: GO:0004875 is_a: CCO:F0000222 ! complement binding is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001230 name: complement component C3a receptor activity namespace: molecular_function def: "Combining with the C3a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0004876 is_a: CCO:F0001229 ! complement receptor activity [Term] id: CCO:F0001231 name: complement component C3b receptor activity namespace: molecular_function def: "Combining with the C3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0004877 is_a: CCO:F0000221 ! opsonin receptor activity is_a: CCO:F0000224 ! complement component C3a binding is_a: CCO:F0001229 ! complement receptor activity [Term] id: CCO:F0001232 name: complement component C5a receptor activity namespace: molecular_function def: "Combining with the C5a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0004878 is_a: CCO:F0000221 ! opsonin receptor activity is_a: CCO:F0000230 ! complement component C5a binding is_a: CCO:F0001229 ! complement receptor activity [Term] id: CCO:F0001233 name: ligand-dependent nuclear receptor activity namespace: molecular_function def: "A ligand-dependent receptor found in the nucleus of the cell." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. synonym: "nuclear hormone receptor" NARROW [] xref: GO:0004879 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0001234 name: juvenile hormone receptor activity namespace: molecular_function def: "Combining with juvenile hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. xref: GO:0004880 is_a: CCO:F0001233 ! ligand-dependent nuclear receptor activity [Term] id: CCO:F0001235 name: androgen receptor activity namespace: molecular_function def: "Combining with an androgen to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. xref: GO:0004882 is_a: CCO:F0000295 ! steroid hormone receptor activity [Term] id: CCO:F0001236 name: glucocorticoid receptor activity namespace: molecular_function def: "Combining with a glucocorticoid to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. xref: GO:0004883 is_a: CCO:F0000295 ! steroid hormone receptor activity [Term] id: CCO:F0001237 name: ecdysteroid hormone receptor activity namespace: molecular_function def: "Combining with ecdysteroid hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. xref: GO:0004884 is_a: CCO:F0000295 ! steroid hormone receptor activity [Term] id: CCO:F0001238 name: retinoid-X receptor activity namespace: molecular_function synonym: "RXR" EXACT [] xref: GO:0004886 is_a: CCO:F0000296 ! retinoic acid receptor activity [Term] id: CCO:F0001239 name: thyroid hormone receptor activity namespace: molecular_function def: "Combining with thyroid hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. xref: GO:0004887 is_a: CCO:F0001233 ! ligand-dependent nuclear receptor activity [Term] id: CCO:F0001240 name: transmembrane receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle." [GOC:go_curators, http://en.wikipedia.org/] subset: gosubset_prok xref: GO:0004888 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0001241 name: nicotinic acetylcholine-activated cation-selective channel activity namespace: molecular_function xref: GO:0004889 xref: GO:0016904 is_a: CCO:F0001506 ! excitatory extracellular ligand-gated ion channel activity is_a: CCO:F0001524 ! cation channel activity [Term] id: CCO:F0001242 name: GABA-A receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. xref: GO:0004890 is_a: CCO:F0003467 ! GABA receptor activity [Term] id: CCO:F0001243 name: glycine-inhibited chloride channel activity namespace: molecular_function comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'receptor activity ; GO:0004872'. xref: GO:0004891 is_a: CCO:F0001509 ! inhibitory extracellular ligand-gated ion channel activity is_a: CCO:F0001522 ! chloride channel activity [Term] id: CCO:F0001244 name: hematopoietin/interferon-class (D200-domain) cytokine receptor activity namespace: molecular_function xref: GO:0004896 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001245 name: ciliary neurotrophic factor receptor activity namespace: molecular_function synonym: "gp130" NARROW [] xref: GO:0004897 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity [Term] id: CCO:F0001246 name: leukemia inhibitory factor receptor beta-protein activity namespace: molecular_function xref: GO:0004899 is_a: CCO:F0001245 ! ciliary neurotrophic factor receptor activity is_a: CCO:F0001376 ! hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity [Term] id: CCO:F0001247 name: erythropoietin receptor activity namespace: molecular_function def: "Combining with erythropoietin to initiate a change in cell activity." [GOC:ai] xref: GO:0004900 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity [Term] id: CCO:F0001248 name: granulocyte macrophage colony-stimulating factor receptor activity namespace: molecular_function def: "Combining with granulocyte macrophage colony-stimulating factor to initiate a change in cell activity." [GOC:mah] synonym: "CSF-2" RELATED [] synonym: "GM-CSF receptor activity" EXACT [] synonym: "GMC-SF receptor activity" EXACT [] xref: GO:0004901 xref: GO:0030525 is_a: CCO:F0001247 ! erythropoietin receptor activity [Term] id: CCO:F0001249 name: granulocyte colony-stimulating factor receptor activity namespace: molecular_function def: "Combining with granulocyte colony-stimulating factor to initiate a change in cell activity." [GOC:mah] xref: GO:0004902 xref: GO:0030524 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity [Term] id: CCO:F0001250 name: growth hormone receptor activity namespace: molecular_function def: "Combining with growth hormone to initiate a change in cell activity." [GOC:ai] xref: GO:0004903 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity [Term] id: CCO:F0001251 name: interferon receptor activity namespace: molecular_function def: "Combining with an interferon to initiate a change in cell activity." [GOC:ai] xref: GO:0004904 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity is_a: CCO:F0004227 ! interferon binding [Term] id: CCO:F0001253 name: interferon-gamma receptor activity namespace: molecular_function def: "Combining with interferon-gamma to initiate a change in cell activity. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383] synonym: "type II interferon receptor activity" EXACT [] xref: GO:0004906 is_a: CCO:F0001251 ! interferon receptor activity is_a: CCO:F0004229 ! interferon-gamma binding [Term] id: CCO:F0001254 name: interleukin receptor activity namespace: molecular_function def: "Combining with an interleukin to initiate a change in cell activity." [GOC:ai] synonym: "IL receptor" EXACT [] xref: GO:0004907 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0001255 name: interleukin-1 receptor activity namespace: molecular_function def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl] synonym: "IL-1R" EXACT [] xref: GO:0004908 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004231 ! interleukin-1 binding [Term] id: CCO:F0001256 name: interleukin-1, Type I, activating receptor activity namespace: molecular_function synonym: "IL-1 type I, activating receptor" EXACT [] xref: GO:0004909 is_a: CCO:F0001255 ! interleukin-1 receptor activity is_a: CCO:F0004232 ! interleukin-1, Type I, activating binding [Term] id: CCO:F0001257 name: interleukin-1, Type II, blocking receptor activity namespace: molecular_function synonym: "IL-1 type II, blocking receptor" EXACT [] xref: GO:0004910 is_a: CCO:F0001255 ! interleukin-1 receptor activity is_a: CCO:F0004233 ! interleukin-1, Type II, blocking binding [Term] id: CCO:F0001258 name: interleukin-2 receptor activity namespace: molecular_function def: "Combining with interleukin-2 to initiate a change in cell activity." [GOC:jl] synonym: "IL-2R" EXACT [] xref: GO:0004911 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004240 ! interleukin-2 binding [Term] id: CCO:F0001259 name: interleukin-3 receptor activity namespace: molecular_function def: "Combining with interleukin-3 to initiate a change in cell activity." [GOC:jl] synonym: "IL-3R" EXACT [] xref: GO:0004912 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004242 ! interleukin-3 binding [Term] id: CCO:F0001260 name: interleukin-4 receptor activity namespace: molecular_function def: "Combining with interleukin-4 to initiate a change in cell activity." [GOC:jl] synonym: "IL-4R" EXACT [] xref: GO:0004913 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004243 ! interleukin-4 binding [Term] id: CCO:F0001261 name: interleukin-5 receptor activity namespace: molecular_function def: "Combining with interleukin-5 to initiate a change in cell activity." [GOC:jl] synonym: "IL-5R" EXACT [] xref: GO:0004914 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004244 ! interleukin-5 binding [Term] id: CCO:F0001262 name: interleukin-6 receptor activity namespace: molecular_function def: "Combining with interleukin-6 to initiate a change in cell activity." [GOC:jl] synonym: "gp130" NARROW [] synonym: "IL-6R" EXACT [] xref: GO:0004915 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004245 ! interleukin-6 binding [Term] id: CCO:F0001263 name: interleukin-7 receptor activity namespace: molecular_function def: "Combining with interleukin-7 to initiate a change in cell activity." [GOC:jl] synonym: "IL-7R" EXACT [] xref: GO:0004917 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004246 ! interleukin-7 binding [Term] id: CCO:F0001264 name: interleukin-8 receptor activity namespace: molecular_function def: "Combining with interleukin-8 to initiate a change in cell activity." [GOC:jl] synonym: "IL-8R" EXACT [] xref: GO:0004918 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0003175 ! C-X-C chemokine receptor activity is_a: CCO:F0004225 ! interleukin-8 binding [Term] id: CCO:F0001265 name: interleukin-9 receptor activity namespace: molecular_function def: "Combining with interleukin-9 to initiate a change in cell activity." [GOC:jl] synonym: "IL-9R" EXACT [] xref: GO:0004919 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004247 ! interleukin-9 binding [Term] id: CCO:F0001266 name: interleukin-10 receptor activity namespace: molecular_function def: "Combining with interleukin-10 to initiate a change in cell activity." [GOC:jl] synonym: "IL-10R" EXACT [] xref: GO:0004920 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004234 ! interleukin-10 binding [Term] id: CCO:F0001267 name: interleukin-11 receptor activity namespace: molecular_function def: "Combining with interleukin-11 to initiate a change in cell activity." [GOC:jl] synonym: "gp130" NARROW [] synonym: "IL-11R" EXACT [] xref: GO:0004921 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004235 ! interleukin-11 binding [Term] id: CCO:F0001268 name: leukemia inhibitory factor receptor activity namespace: molecular_function def: "Combining with leukemia inhibitory factor to initiate a change in cell activity." [GOC:mah] xref: GO:0004923 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity [Term] id: CCO:F0001269 name: oncostatin-M receptor activity namespace: molecular_function def: "Combining with oncostatin-M to initiate a change in cell activity." [GOC:mah] xref: GO:0004924 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity [Term] id: CCO:F0001270 name: prolactin receptor activity namespace: molecular_function def: "Combining with prolactin to initiate a change in cell activity." [GOC:mah] xref: GO:0004925 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity [Term] id: CCO:F0001271 name: non-G-protein coupled 7TM receptor activity namespace: molecular_function subset: gosubset_prok synonym: "non G protein coupled 7TM receptor activity" EXACT [] synonym: "non-G-protein-coupled 7TM receptor activity" EXACT [] xref: GO:0004926 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001272 name: G-protein coupled receptor activity namespace: molecular_function def: "A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers." [GOC:dph, GOC:tb, IUPHAR:2.0] subset: gosubset_prok synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" EXACT [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "G-protein-coupled receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "orphan G protein coupled receptor activity" EXACT [] synonym: "orphan G-protein coupled receptor activity" EXACT [] synonym: "orphan GPCR activity" EXACT [] xref: GO:0004930 xref: GO:0016526 xref: Reactome:35 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001273 name: ATP-gated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts." [GOC:mah, PMID:9755289] comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'. synonym: "P2X activity" RELATED [] synonym: "purinoceptor" BROAD [] synonym: "purinoreceptor" BROAD [] xref: GO:0004931 is_a: CCO:F0001506 ! excitatory extracellular ligand-gated ion channel activity is_a: CCO:F0001524 ! cation channel activity [Term] id: CCO:F0001274 name: mating-type factor pheromone receptor activity namespace: molecular_function def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph] subset: gosubset_prok xref: GO:0004932 is_a: CCO:F0003184 ! pheromone receptor activity [Term] id: CCO:F0001275 name: mating-type a-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] xref: GO:0004933 is_a: CCO:F0001274 ! mating-type factor pheromone receptor activity [Term] id: CCO:F0001276 name: mating-type alpha-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] xref: GO:0004934 is_a: CCO:F0001274 ! mating-type factor pheromone receptor activity [Term] id: CCO:F0001277 name: adrenoceptor activity namespace: molecular_function synonym: "adrenergic receptor" EXACT [] xref: GO:0004935 is_a: CCO:F0001782 ! amine receptor activity [Term] id: CCO:F0001278 name: alpha-adrenergic receptor activity namespace: molecular_function synonym: "alpha adrenoceptor" EXACT [] xref: GO:0004936 is_a: CCO:F0001277 ! adrenoceptor activity [Term] id: CCO:F0001279 name: alpha1-adrenergic receptor activity namespace: molecular_function synonym: "alpha1 adrenoceptor" EXACT [] xref: GO:0004937 is_a: CCO:F0001278 ! alpha-adrenergic receptor activity [Term] id: CCO:F0001280 name: alpha2-adrenergic receptor activity namespace: molecular_function synonym: "alpha2 adrenoceptor" EXACT [] xref: GO:0004938 is_a: CCO:F0001278 ! alpha-adrenergic receptor activity [Term] id: CCO:F0001281 name: beta-adrenergic receptor activity namespace: molecular_function synonym: "beta adrenoceptor" EXACT [] xref: GO:0004939 is_a: CCO:F0001277 ! adrenoceptor activity [Term] id: CCO:F0001282 name: beta1-adrenergic receptor activity namespace: molecular_function synonym: "beta1 adrenoceptor" EXACT [] xref: GO:0004940 is_a: CCO:F0001281 ! beta-adrenergic receptor activity [Term] id: CCO:F0001283 name: beta2-adrenergic receptor activity namespace: molecular_function synonym: "beta2 adrenoceptor" EXACT [] xref: GO:0004941 is_a: CCO:F0001281 ! beta-adrenergic receptor activity [Term] id: CCO:F0001284 name: anaphylatoxin receptor activity namespace: molecular_function def: "Combining with anaphylatoxin to initiate a change in cell activity." [GOC:ai] xref: GO:0004942 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0001285 name: C3a anaphylatoxin receptor activity namespace: molecular_function def: "Combining with anaphylatoxin C3a to initiate a change in cell activity." [GOC:mah] xref: GO:0004943 is_a: CCO:F0001284 ! anaphylatoxin receptor activity [Term] id: CCO:F0001286 name: C5a anaphylatoxin receptor activity namespace: molecular_function def: "Combining with anaphylatoxin C5a to initiate a change in cell activity." [GOC:mah] xref: GO:0004944 is_a: CCO:F0001284 ! anaphylatoxin receptor activity [Term] id: CCO:F0001287 name: angiotensin type II receptor activity namespace: molecular_function xref: GO:0004945 is_a: CCO:F0000151 ! angiotensin receptor activity [Term] id: CCO:F0001288 name: bombesin receptor activity namespace: molecular_function def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai] xref: GO:0004946 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0001289 name: bradykinin receptor activity namespace: molecular_function def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai] xref: GO:0004947 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0001290 name: calcitonin receptor activity namespace: molecular_function def: "Combining with calcitonin to initiate a change in cell activity." [GOC:mah] xref: GO:0004948 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0001291 name: cannabinoid receptor activity namespace: molecular_function def: "Combining with cannabinoids to initiate a change in cell activity." [GOC:dph, IUPHAR:2.1.CBD] synonym: "cannaboid receptor" EXACT [] xref: GO:0004949 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0001292 name: chemokine receptor activity namespace: molecular_function def: "Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity." [IUPHAR:2.1, PMID:8662823] xref: GO:0004950 is_a: CCO:F0000187 ! G-protein chemoattractant receptor activity is_a: CCO:F0004222 ! chemokine binding [Term] id: CCO:F0001293 name: cholecystokinin receptor activity namespace: molecular_function def: "Combining with cholecystokinin, a 33-amino acid peptide secreted by the upper intestinal mucosa and also found in the central nervous system, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/] xref: GO:0004951 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0001294 name: dopamine receptor activity namespace: molecular_function def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR:2.1] xref: GO:0004952 is_a: CCO:F0001782 ! amine receptor activity is_a: CCO:F0004488 ! neurotransmitter receptor activity is_a: CCO:F0005573 ! dopamine binding [Term] id: CCO:F0001295 name: icosanoid receptor activity namespace: molecular_function def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph] synonym: "eicosanoid receptor activity" EXACT [] xref: GO:0004953 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0001296 name: prostanoid receptor activity namespace: molecular_function def: "Combining with a prostanoid, any compound based on or derive4d from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0004954 is_a: CCO:F0001295 ! icosanoid receptor activity [Term] id: CCO:F0001297 name: prostaglandin receptor activity namespace: molecular_function def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0004955 is_a: CCO:F0001296 ! prostanoid receptor activity [Term] id: CCO:F0001298 name: prostaglandin D receptor activity namespace: molecular_function def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGD receptor activity" RELATED [] synonym: "PGD(2) receptor activity" EXACT [] xref: GO:0004956 is_a: CCO:F0001297 ! prostaglandin receptor activity [Term] id: CCO:F0001299 name: prostaglandin E receptor activity namespace: molecular_function def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGE receptor activity" RELATED [] synonym: "PGE(2) receptor activity" EXACT [] xref: GO:0004957 is_a: CCO:F0001297 ! prostaglandin receptor activity [Term] id: CCO:F0001300 name: prostaglandin F receptor activity namespace: molecular_function def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGF receptor activity" RELATED [] synonym: "PGF(2-alpha) receptor activity" EXACT [] xref: GO:0004958 is_a: CCO:F0001297 ! prostaglandin receptor activity [Term] id: CCO:F0001301 name: thromboxane receptor activity namespace: molecular_function def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "TXA receptor activity" EXACT [] xref: GO:0004960 is_a: CCO:F0001296 ! prostanoid receptor activity [Term] id: CCO:F0001302 name: thromboxane A2 receptor activity namespace: molecular_function def: "Combining with thromboxane A2 (TXA(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "TXA(2) receptor activity" EXACT [] xref: GO:0004961 is_a: CCO:F0001301 ! thromboxane receptor activity [Term] id: CCO:F0001303 name: endothelin receptor activity namespace: molecular_function def: "Combining with endothelin to initiate a change in cell activity." [GOC:dph, IUPHAR:2.1] xref: GO:0004962 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0001304 name: follicle-stimulating hormone receptor activity namespace: molecular_function def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "follicle stimulating hormone receptor activity" EXACT [] xref: GO:0004963 is_a: CCO:F0003181 ! protein-hormone receptor activity [Term] id: CCO:F0001305 name: lutropin-choriogonadotropic hormone receptor activity namespace: molecular_function def: "Combining with lutropin-choriogonadotropic hormone to initiate a change in cell activity." [GOC:mah] xref: GO:0004964 xref: GO:0004976 is_a: CCO:F0003181 ! protein-hormone receptor activity [Term] id: CCO:F0001306 name: GABA-B receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors." [GOC:ai, IUPHAR:2.3] xref: GO:0004965 is_a: CCO:F0001696 ! metabotropic glutamate, GABA-B-like receptor activity is_a: CCO:F0003467 ! GABA receptor activity [Term] id: CCO:F0001307 name: galanin receptor activity namespace: molecular_function def: "Combining with galanin to initiate a change in cell activity." [GOC:ai] xref: GO:0004966 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0001308 name: glucagon receptor activity namespace: molecular_function def: "Combining with glucagon to initiate a change in cell activity." [GOC:mah] xref: GO:0004967 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0001309 name: gonadotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] xref: GO:0004968 is_a: CCO:F0003181 ! protein-hormone receptor activity [Term] id: CCO:F0001310 name: histamine receptor activity namespace: molecular_function def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] xref: GO:0004969 is_a: CCO:F0001782 ! amine receptor activity [Term] id: CCO:F0001311 name: ionotropic glutamate receptor activity namespace: molecular_function def: "Combining with glutamate to initiate a change in cell activity through the regulation of ion channels." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'. subset: gosubset_prok xref: GO:0004970 is_a: CCO:F0001695 ! glutamate receptor activity [Term] id: CCO:F0001312 name: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity namespace: molecular_function comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'inotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. xref: GO:0004971 is_a: CCO:F0001311 ! ionotropic glutamate receptor activity [Term] id: CCO:F0001313 name: N-methyl-D-aspartate selective glutamate receptor activity namespace: molecular_function comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'inotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. synonym: "NMDA receptor" EXACT [] xref: GO:0004972 is_a: CCO:F0001311 ! ionotropic glutamate receptor activity [Term] id: CCO:F0001314 name: leukotriene receptor activity namespace: molecular_function def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0004974 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0001315 name: melanocortin receptor activity namespace: molecular_function def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] xref: GO:0004977 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0001316 name: adrenocorticotropin receptor activity namespace: molecular_function def: "Combining with adrenocorticotropin to initiate a change in cell activity." [GOC:ai] synonym: "ACTH receptor activity" EXACT [] synonym: "adrenocorticotropic hormone receptor activity" EXACT [] xref: GO:0004978 is_a: CCO:F0001315 ! melanocortin receptor activity is_a: CCO:F0001769 ! neuropeptide receptor activity is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0001317 name: beta-endorphin receptor activity namespace: molecular_function def: "Combining with beta-endorphin to initiate a change in cell activity." [GOC:ai] xref: GO:0004979 is_a: CCO:F0001315 ! melanocortin receptor activity is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0001318 name: melanocyte stimulating hormone receptor activity namespace: molecular_function def: "Combining with melanocyte stimulating hormone to initiate a change in cell activity." [GOC:jl, UniProtKB:Q01726] synonym: "melanophore stimulating hormone receptor activity" EXACT [] synonym: "MSH receptor activity" BROAD [] synonym: "MSHR activity" BROAD [] xref: GO:0004980 is_a: CCO:F0001315 ! melanocortin receptor activity is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0001319 name: muscarinic acetylcholine receptor activity namespace: molecular_function xref: GO:0004981 is_a: CCO:F0001782 ! amine receptor activity is_a: CCO:F0002870 ! acetylcholine receptor activity [Term] id: CCO:F0001320 name: N-formyl peptide receptor activity namespace: molecular_function def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai] synonym: "Fmet-leu-phe receptor" EXACT [] xref: GO:0004982 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0001321 name: neuropeptide Y receptor activity namespace: molecular_function def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] xref: GO:0004983 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0001322 name: olfactory receptor activity namespace: molecular_function def: "Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell." [GOC:dph] xref: GO:0004984 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0001323 name: opioid receptor activity namespace: molecular_function def: "Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/] xref: GO:0004985 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0001324 name: delta-opioid receptor activity namespace: molecular_function xref: GO:0004986 is_a: CCO:F0001323 ! opioid receptor activity [Term] id: CCO:F0001325 name: kappa-opioid receptor activity namespace: molecular_function xref: GO:0004987 is_a: CCO:F0001323 ! opioid receptor activity [Term] id: CCO:F0001326 name: mu-opioid receptor activity namespace: molecular_function xref: GO:0004988 is_a: CCO:F0001323 ! opioid receptor activity [Term] id: CCO:F0001327 name: octopamine receptor activity namespace: molecular_function def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [GOC:ai, http://cancerweb.ncl.ac.uk/] xref: GO:0004989 is_a: CCO:F0001782 ! amine receptor activity [Term] id: CCO:F0001328 name: oxytocin receptor activity namespace: molecular_function def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai] xref: GO:0004990 is_a: CCO:F0000158 ! vasopressin-like receptor activity [Term] id: CCO:F0001329 name: parathyroid hormone receptor activity namespace: molecular_function def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah] xref: GO:0004991 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0001330 name: platelet activating factor receptor activity namespace: molecular_function def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah] synonym: "PAF receptor activity" EXACT [] xref: GO:0004992 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0001331 name: serotonin receptor activity namespace: molecular_function def: "Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/] synonym: "5-HT receptor" EXACT [] synonym: "5-hydroxytryptamine receptor" EXACT [] xref: GO:0001585 xref: GO:0004993 is_a: CCO:F0001782 ! amine receptor activity [Term] id: CCO:F0001332 name: somatostatin receptor activity namespace: molecular_function def: "Combining with somatostatin to initiate a change in cell activity." [GOC:ai] xref: GO:0004994 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0001333 name: tachykinin receptor activity namespace: molecular_function def: "Combining with tachykinin to initiate a change in cell activity." [GOC:ai] xref: GO:0004995 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0001334 name: thyroid-stimulating hormone receptor activity namespace: molecular_function def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "thyrotropin receptor" EXACT [] xref: GO:0004996 is_a: CCO:F0003181 ! protein-hormone receptor activity [Term] id: CCO:F0001335 name: thyrotropin-releasing hormone receptor activity namespace: molecular_function xref: GO:0004997 is_a: CCO:F0000166 ! thyrotropin releasing hormone and secretagogue-like receptors activity [Term] id: CCO:F0001336 name: transferrin receptor activity namespace: molecular_function def: "Combining with transferrin to initiate a change in cell activity." [GOC:mah] subset: gosubset_prok xref: GO:0004998 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001337 name: vasoactive intestinal polypeptide receptor activity namespace: molecular_function xref: GO:0004999 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0001338 name: vasopressin receptor activity namespace: molecular_function def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] xref: GO:0005000 is_a: CCO:F0000158 ! vasopressin-like receptor activity [Term] id: CCO:F0001339 name: transmembrane receptor protein tyrosine phosphatase activity namespace: molecular_function xref: GO:0005001 is_a: CCO:F0001090 ! protein tyrosine phosphatase activity is_a: CCO:F0004121 ! transmembrane receptor protein phosphatase activity [Term] id: CCO:F0001340 name: ephrin receptor activity namespace: molecular_function def: "Combining with an ephrin to initiate a change in cell activity." [GOC:mah] synonym: "Eph receptor activity" EXACT [] xref: GO:0005003 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001341 name: GPI-linked ephrin receptor activity namespace: molecular_function synonym: "GPI-linked Eph receptor activity" EXACT [] xref: GO:0005004 is_a: CCO:F0001340 ! ephrin receptor activity [Term] id: CCO:F0001342 name: transmembrane-ephrin receptor activity namespace: molecular_function synonym: "transmembrane-Eph receptor activity" EXACT [] xref: GO:0005005 is_a: CCO:F0001340 ! ephrin receptor activity [Term] id: CCO:F0001343 name: epidermal growth factor receptor activity namespace: molecular_function def: "Combining with an epidermal growth factor to initiate a change in cell activity." [GOC:bf] subset: gosubset_prok synonym: "EGF receptor activity" EXACT [] synonym: "EGFR" EXACT [] synonym: "TGF-alpha receptor activity" EXACT [] synonym: "transforming growth factor-alpha receptor activity" EXACT [] xref: GO:0005006 xref: GO:0005023 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001344 name: fibroblast growth factor receptor activity namespace: molecular_function def: "Combining with fibroblast growth factor to initiate a change in cell activity." [GOC:mah] synonym: "FGF receptor activity" EXACT [] synonym: "FGFR" EXACT [] xref: GO:0005007 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001345 name: hepatocyte growth factor receptor activity namespace: molecular_function def: "Combining with hepatocye growth factor to initiate a change in cell activity." [GOC:mah] synonym: "HGF receptor activity" EXACT [] xref: GO:0005008 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001346 name: insulin receptor activity namespace: molecular_function def: "Combining with insulin to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005009 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001347 name: insulin-like growth factor receptor activity namespace: molecular_function synonym: "IGF receptor activity" EXACT [] xref: GO:0005010 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001348 name: macrophage colony stimulating factor receptor activity namespace: molecular_function def: "Combining with macrophage colony stimulating factor to initiate a change in cell activity." [GOC:mah] synonym: "CSF-1" NARROW [] synonym: "Fms" NARROW [] xref: GO:0005011 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001349 name: platelet-derived growth factor receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor to initiate a change in cell activity." [GOC:mah] synonym: "PDGF receptor activity" EXACT [] synonym: "PDGFR activity" EXACT [] xref: GO:0005017 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001350 name: platelet-derived growth factor alpha-receptor activity namespace: molecular_function synonym: "PDGF alpha-receptor activity" EXACT [] xref: GO:0005018 is_a: CCO:F0001349 ! platelet-derived growth factor receptor activity [Term] id: CCO:F0001351 name: platelet-derived growth factor beta-receptor activity namespace: molecular_function synonym: "PDGF beta-receptor activity" EXACT [] xref: GO:0005019 is_a: CCO:F0001349 ! platelet-derived growth factor receptor activity [Term] id: CCO:F0001352 name: stem cell factor receptor activity namespace: molecular_function def: "Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity." [GOC:jl, PMID:10698217] xref: GO:0005020 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001353 name: vascular endothelial growth factor receptor activity namespace: molecular_function def: "Combining with vascular endothelial growth factor to initiate a change in cell activity." [GOC:mah] xref: GO:0005021 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001354 name: transforming growth factor beta receptor activity namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity." [GOC:mah] synonym: "TGF-beta receptor activity" EXACT [] synonym: "TGFbeta receptor activity" EXACT [] synonym: "TGFbetaR" EXACT [] xref: GO:0005024 is_a: CCO:F0001046 ! transmembrane receptor protein serine/threonine kinase activity [Term] id: CCO:F0001355 name: transforming growth factor beta receptor activity, type I namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "type I TGF-beta receptor activity" EXACT [] synonym: "type I TGFbeta receptor activity" EXACT [] synonym: "type I transforming growth factor beta receptor activity" EXACT [] xref: GO:0005025 is_a: CCO:F0001354 ! transforming growth factor beta receptor activity [Term] id: CCO:F0001356 name: transforming growth factor beta receptor activity, type II namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, catalyzes the phosphorylation of a type I activin receptor." [GOC:mah] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "type II TGF-beta receptor activity" EXACT [] synonym: "type II TGFbeta receptor activity" EXACT [] synonym: "type II transforming growth factor beta receptor activity" EXACT [] xref: GO:0005026 xref: Reactome:11166 is_a: CCO:F0001354 ! transforming growth factor beta receptor activity [Term] id: CCO:F0001357 name: neurotrophin receptor activity namespace: molecular_function def: "Combining with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth, to initiate a change in cell activity." [GOC:jl, http://www.mercksource.com/] xref: GO:0005030 is_a: CCO:F0001226 ! receptor activity is_a: CCO:F0005795 ! neurotrophin binding [Term] id: CCO:F0001358 name: tumor necrosis factor receptor activity namespace: molecular_function def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/] synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW [] synonym: "TNF receptor activity" EXACT [] synonym: "TNF receptor activity, type I" NARROW [] synonym: "TNF receptor activity, type II" NARROW [] synonym: "tumor necrosis factor receptor activity, type I" NARROW [] synonym: "tumor necrosis factor receptor activity, type II" NARROW [] xref: GO:0005031 xref: GO:0005032 xref: GO:0005033 is_a: CCO:F0001360 ! death receptor activity is_a: CCO:F0005794 ! tumor necrosis factor binding [Term] id: CCO:F0001359 name: osmosensor activity namespace: molecular_function xref: GO:0005034 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001360 name: death receptor activity namespace: molecular_function xref: GO:0005035 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001361 name: decoy death receptor activity namespace: molecular_function xref: GO:0005040 is_a: CCO:F0001360 ! death receptor activity [Term] id: CCO:F0001362 name: low-density lipoprotein receptor activity namespace: molecular_function def: "Combining with a low-density lipoprotein to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "LDL receptor" EXACT [] xref: GO:0005041 xref: GO:0008032 is_a: CCO:F0004336 ! low-density lipoprotein binding is_a: CCO:F0004351 ! lipoprotein receptor activity [Term] id: CCO:F0001363 name: netrin receptor activity namespace: molecular_function def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemotaxis when activated." [GOC:dph] xref: GO:0005042 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001364 name: repulsive netrin receptor activity namespace: molecular_function def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemorepulsion when activated." [GOC:dph] xref: GO:0005043 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001365 name: scavenger receptor activity namespace: molecular_function def: "Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity." [PMID:11790542, PMID:12379907, PMID:12621157] comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. subset: gosubset_prok synonym: "macrophage receptor activity" EXACT [] xref: GO:0005044 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001366 name: KDEL sequence binding namespace: molecular_function def: "Interacting selectively with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai] synonym: "KDEL receptor activity" NARROW [] xref: GO:0005046 is_a: CCO:F0006275 ! ER retention sequence binding [Term] id: CCO:F0001367 name: signal recognition particle binding namespace: molecular_function def: "Interacting selectively with the signal recognition particle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'. subset: gosubset_prok synonym: "docking protein" BROAD [] synonym: "signal recognition particle receptor" NARROW [] xref: GO:0005047 is_a: CCO:F0005783 ! ribonucleoprotein binding [Term] id: CCO:F0001368 name: signal sequence binding namespace: molecular_function def: "Interacting selectively with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] subset: gosubset_prok synonym: "leader sequence binding" NARROW [] synonym: "protein signal sequence binding" NARROW [] synonym: "signal sequence receptor" NARROW [] xref: GO:0005048 xref: GO:0008249 is_a: CCO:F0005639 ! peptide binding [Term] id: CCO:F0001369 name: nuclear export signal receptor activity namespace: molecular_function def: "Combining with a nuclear export signal to initiate a change in cell activity." [GOC:ai] synonym: "NES receptor" EXACT [] xref: GO:0005049 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001370 name: peroxisome matrix targeting signal-1 binding namespace: molecular_function def: "Interacting selectively with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502] synonym: "peroxisome targeting signal-1 binding" EXACT [] synonym: "peroxisome targeting signal-1 receptor" NARROW [] synonym: "PEX5" NARROW [] synonym: "PTS1 receptor" NARROW [] xref: GO:0005052 is_a: CCO:F0000054 ! peroxisome targeting sequence binding [Term] id: CCO:F0001371 name: peroxisome matrix targeting signal-2 binding namespace: molecular_function def: "Interacting selectively with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502] synonym: "peroxisome targeting signal-2 binding" EXACT [] synonym: "peroxisome targeting signal-2 receptor" NARROW [] synonym: "PEX7" NARROW [] synonym: "PTS2 receptor" EXACT [] xref: GO:0005053 is_a: CCO:F0000054 ! peroxisome targeting sequence binding [Term] id: CCO:F0001372 name: laminin receptor activity namespace: molecular_function def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. subset: gosubset_prok xref: GO:0005055 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001373 name: tiggrin receptor activity namespace: molecular_function xref: GO:0005056 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001374 name: receptor signaling protein activity namespace: molecular_function synonym: "receptor signalling protein activity" EXACT [] xref: GO:0005057 is_a: CCO:F0001225 ! signal transducer activity [Term] id: CCO:F0001375 name: aryl hydrocarbon receptor nuclear translocator activity namespace: molecular_function xref: GO:0005061 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001376 name: hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity namespace: molecular_function synonym: "gp130" NARROW [] xref: GO:0005062 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001377 name: transmembrane receptor protein tyrosine kinase signaling protein activity namespace: molecular_function synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT [] xref: GO:0005066 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001378 name: transmembrane receptor protein tyrosine kinase adaptor protein activity namespace: molecular_function def: "The binding activity of a molecule that brings together a transmembrane receptor protein kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT] xref: GO:0005068 is_a: CCO:F0001377 ! transmembrane receptor protein tyrosine kinase signaling protein activity is_a: CCO:F0008241 ! molecular adaptor activity [Term] id: CCO:F0001379 name: transmembrane receptor protein tyrosine kinase docking protein activity namespace: molecular_function xref: GO:0005069 is_a: CCO:F0001377 ! transmembrane receptor protein tyrosine kinase signaling protein activity [Term] id: CCO:F0001380 name: SH3/SH2 adaptor activity namespace: molecular_function def: "Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so] synonym: "SH3/SH2 adaptor protein activity" NARROW [] xref: GO:0005070 is_a: CCO:F0001225 ! signal transducer activity is_a: CCO:F0004516 ! protein binding, bridging is_a: CCO:F0008241 ! molecular adaptor activity [Term] id: CCO:F0001381 name: transmembrane receptor protein serine/threonine kinase signaling protein activity namespace: molecular_function synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT [] xref: GO:0005071 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001382 name: transforming growth factor beta receptor, cytoplasmic mediator activity namespace: molecular_function def: "Activity of any of the molecules that transmit the signal from a TGFbeta receptor through the cytoplasm to the nucleus." [GOC:hjd] comment: Note that this term and its children are useful for annotating proteins of the SMAD family. synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT [] xref: GO:0005072 is_a: CCO:F0001381 ! transmembrane receptor protein serine/threonine kinase signaling protein activity [Term] id: CCO:F0001383 name: receptor signaling protein serine/threonine kinase signaling protein activity namespace: molecular_function synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT [] xref: GO:0005076 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001384 name: MAP-kinase scaffold activity namespace: molecular_function def: "Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins." [PMID:12511654] synonym: "MAP-kinase scaffold protein activity" EXACT [] xref: GO:0005078 is_a: CCO:F0004332 ! receptor signaling complex scaffold activity [Term] id: CCO:F0001385 name: protein kinase C binding namespace: molecular_function def: "Interacting selectively with protein kinase C." [GOC:jl] synonym: "PKC binding" EXACT [] xref: GO:0005080 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0001386 name: receptor signaling protein serine/threonine phosphatase signaling protein activity namespace: molecular_function synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT [] xref: GO:0005081 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001387 name: receptor signaling protein tyrosine phosphatase signaling protein activity namespace: molecular_function synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT [] xref: GO:0005082 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001388 name: small GTPase regulator activity namespace: molecular_function def: "Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah] subset: gosubset_prok synonym: "small GTPase regulatory/interacting protein activity" RELATED [] xref: GO:0005083 is_a: CCO:F0004520 ! GTPase regulator activity [Term] id: CCO:F0001390 name: guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] subset: gosubset_prok synonym: "GEF" EXACT [] synonym: "GNRP" NARROW [] synonym: "guanyl-nucleotide release factor activity" EXACT [] synonym: "guanyl-nucleotide releasing factor" EXACT [] xref: GO:0005085 xref: GO:0008433 xref: GO:0019839 xref: Reactome:11431 is_a: CCO:F0004520 ! GTPase regulator activity [Term] id: CCO:F0001391 name: ARF guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: GO:0005086 is_a: CCO:F0001388 ! small GTPase regulator activity is_a: CCO:F0001390 ! guanyl-nucleotide exchange factor activity [Term] id: CCO:F0001392 name: Ran guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "RCC1" EXACT [] xref: GO:0005087 xref: Reactome:11435 is_a: CCO:F0001393 ! Ras guanyl-nucleotide exchange factor activity [Term] id: CCO:F0001393 name: Ras guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: GO:0005088 xref: Reactome:11436 is_a: CCO:F0001388 ! small GTPase regulator activity is_a: CCO:F0001390 ! guanyl-nucleotide exchange factor activity [Term] id: CCO:F0001394 name: Rho guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "Rho guanine nucleotide exchange factor" EXACT [] synonym: "RhoGEF" EXACT [] xref: GO:0005089 is_a: CCO:F0001393 ! Ras guanyl-nucleotide exchange factor activity [Term] id: CCO:F0001395 name: Sar guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by the GTPase Sar. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: GO:0005090 is_a: CCO:F0001388 ! small GTPase regulator activity is_a: CCO:F0001390 ! guanyl-nucleotide exchange factor activity [Term] id: CCO:F0001396 name: guanyl-nucleotide exchange factor adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT] xref: GO:0005091 is_a: CCO:F0001388 ! small GTPase regulator activity is_a: CCO:F0008241 ! molecular adaptor activity [Term] id: CCO:F0001397 name: GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah] synonym: "GDI" EXACT [] xref: GO:0005092 is_a: CCO:F0001388 ! small GTPase regulator activity [Term] id: CCO:F0001398 name: Rab GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah] xref: GO:0005093 is_a: CCO:F0001397 ! GDP-dissociation inhibitor activity [Term] id: CCO:F0001399 name: Rho GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah] xref: GO:0005094 is_a: CCO:F0001397 ! GDP-dissociation inhibitor activity [Term] id: CCO:F0001400 name: GTPase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai] synonym: "GIP" BROAD [] xref: GO:0005095 is_a: CCO:F0001213 ! enzyme inhibitor activity is_a: CCO:F0004520 ! GTPase regulator activity [Term] id: CCO:F0001401 name: GTPase activator activity namespace: molecular_function def: "Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] subset: gosubset_prok synonym: "GAP" BROAD [] xref: GO:0005096 xref: Reactome:11473 is_a: CCO:F0001691 ! enzyme activator activity is_a: CCO:F0004520 ! GTPase regulator activity [Term] id: CCO:F0001402 name: Rab GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah] xref: GO:0005097 is_a: CCO:F0001404 ! Ras GTPase activator activity [Term] id: CCO:F0001403 name: Ran GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Ran family." [GOC:mah] synonym: "RanGAP" RELATED [] xref: GO:0005098 is_a: CCO:F0001404 ! Ras GTPase activator activity [Term] id: CCO:F0001404 name: Ras GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily." [GOC:mah] xref: GO:0005099 is_a: CCO:F0001388 ! small GTPase regulator activity is_a: CCO:F0001401 ! GTPase activator activity [Term] id: CCO:F0001405 name: Rho GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rho family." [GOC:mah] xref: GO:0005100 is_a: CCO:F0001404 ! Ras GTPase activator activity [Term] id: CCO:F0001406 name: Sar GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by the GTPase Sar." [GOC:mah] xref: GO:0005101 is_a: CCO:F0001388 ! small GTPase regulator activity is_a: CCO:F0001401 ! GTPase activator activity [Term] id: CCO:F0001407 name: receptor binding namespace: molecular_function def: "Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "adrenocorticotropin" RELATED [] synonym: "allatostatin" RELATED [] synonym: "insulin" RELATED [] synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: GO:0005102 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001408 name: baboon binding namespace: molecular_function def: "Interacting selectively with the baboon (babo) protein, a type I transforming growth factor beta receptor." [GOC:ceb] synonym: "babo binding" EXACT [] synonym: "babo ligand" NARROW [] synonym: "baboon ligand" NARROW [] synonym: "baboon receptor ligand" NARROW [] xref: GO:0005103 is_a: CCO:F0001462 ! transforming growth factor beta receptor binding [Term] id: CCO:F0001409 name: fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively with the fibroblast growth factor receptor (FGFR)." [GOC:ceb] comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor. synonym: "FGF receptor binding" EXACT [] synonym: "FGFR binding" EXACT [] synonym: "FGFR ligand" NARROW [] synonym: "fibroblast growth factor" BROAD [] synonym: "fibroblast growth factor receptor ligand" NARROW [] xref: GO:0001521 xref: GO:0005104 xref: GO:0005162 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0001410 name: type 1 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively with the type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators] comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1). synonym: "breathless binding" NARROW [] synonym: "breathless ligand" NARROW [] synonym: "FGFR1 binding" BROAD [] synonym: "FGFR1 ligand" NARROW [] synonym: "type 1 fibroblast growth factor receptor ligand" NARROW [] xref: GO:0005105 is_a: CCO:F0001409 ! fibroblast growth factor receptor binding [Term] id: CCO:F0001411 name: frizzled binding namespace: molecular_function def: "Interacting selectively with the frizzled (fz) receptor." [GOC:ceb] synonym: "frizzled ligand" NARROW [] synonym: "fz binding" EXACT [] synonym: "fz ligand" NARROW [] xref: GO:0005109 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0001412 name: frizzled-2 binding namespace: molecular_function def: "Interacting selectively with frizzled-2 (fz2)." [GOC:ceb] synonym: "frizzled-2 ligand" NARROW [] synonym: "fz2 binding" EXACT [] synonym: "fz2 ligand" NARROW [] xref: GO:0005110 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0001413 name: type 2 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively with the type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators] comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2). synonym: "FGFR2 binding" EXACT [] synonym: "FGFR2 ligand" NARROW [] synonym: "heartless binding" EXACT [] synonym: "heartless ligand" NARROW [] synonym: "type 2 fibroblast growth factor receptor ligand" NARROW [] xref: GO:0005111 is_a: CCO:F0001409 ! fibroblast growth factor receptor binding [Term] id: CCO:F0001414 name: Notch binding namespace: molecular_function def: "Interacting selectively with the Notch (N) protein, a surface receptor." [GOC:ceb] synonym: "N binding" EXACT [] synonym: "N ligand" NARROW [] synonym: "Notch ligand" NARROW [] synonym: "Notch receptor binding" EXACT [] xref: GO:0005112 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001415 name: patched binding namespace: molecular_function def: "Interacting selectively with the patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473] synonym: "patched ligand" NARROW [] synonym: "ptc binding" EXACT [] synonym: "ptc ligand" NARROW [] xref: GO:0005113 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001416 name: punt binding namespace: molecular_function def: "Interacting selectively with the punt protein, a type II transforming growth factor beta receptor." [GOC:bf] synonym: "punt ligand" NARROW [] synonym: "put binding" EXACT [] synonym: "put ligand" NARROW [] xref: GO:0005114 is_a: CCO:F0001462 ! transforming growth factor beta receptor binding [Term] id: CCO:F0001417 name: receptor tyrosine kinase-like orphan receptor binding namespace: molecular_function def: "Interaction with the receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb] synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW [] synonym: "Ror binding" BROAD [] synonym: "Ror ligand" RELATED [] xref: GO:0005115 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001418 name: saxophone binding namespace: molecular_function def: "Interacting selectively with the saxophone (sax) protein, a type I transforming growth factor beta receptor." [GOC:ceb, PMID:11252892] synonym: "sax binding" EXACT [] synonym: "sax ligand" NARROW [] synonym: "saxophone ligand" NARROW [] xref: GO:0005116 is_a: CCO:F0001462 ! transforming growth factor beta receptor binding [Term] id: CCO:F0001419 name: wishful thinking binding namespace: molecular_function def: "Interacting selectively with wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529] synonym: "SE20 receptor binding" NARROW [] synonym: "wishful thinking ligand" NARROW [] synonym: "Wit binding" EXACT [] synonym: "Wit ligand" NARROW [] xref: GO:0005117 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001420 name: sevenless binding namespace: molecular_function def: "Interacting selectively with the sevenless (sev) protein, a receptor tyrosine kinase." [FB:gn0003366, GOC:ceb] synonym: "sev binding" EXACT [] synonym: "sev ligand" NARROW [] synonym: "sevenless ligand" NARROW [] xref: GO:0005118 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001421 name: smoothened binding namespace: molecular_function def: "Interacting selectively with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473] synonym: "smo binding" EXACT [] synonym: "smo ligand" NARROW [] synonym: "smoothened ligand" NARROW [] xref: GO:0005119 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001422 name: thickveins binding namespace: molecular_function def: "Interacting selectively with the thickveins (tkv) protein, a type I transforming growth factor beta receptor." [GOC:ceb, PMID:11252892] synonym: "thickveins ligand" NARROW [] synonym: "tkv binding" EXACT [] synonym: "tkv ligand" NARROW [] xref: GO:0005120 is_a: CCO:F0001462 ! transforming growth factor beta receptor binding [Term] id: CCO:F0001423 name: Toll binding namespace: molecular_function def: "Interacting selectively with the Toll protein, a transmembrane receptor." [GOC:ceb] synonym: "Tl binding" EXACT [] synonym: "Toll ligand" NARROW [] synonym: "Toll receptor binding" EXACT [] xref: GO:0005121 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001424 name: torso binding namespace: molecular_function def: "Interacting selectively with the torso (tor) protein, a receptor tyrosine kinase." [FB:gn0003733, GOC:ceb] synonym: "tor binding" EXACT [] synonym: "tor ligand" NARROW [] synonym: "torso ligand" NARROW [] xref: GO:0005122 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001425 name: death receptor binding namespace: molecular_function def: "Interacting selectively with a death receptor." [GOC:ceb] synonym: "death receptor adaptor protein activity" RELATED [] synonym: "death receptor interacting protein activity" RELATED [] synonym: "death receptor ligand" NARROW [] synonym: "death receptor-associated factor activity" RELATED [] xref: GO:0005123 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001426 name: scavenger receptor binding namespace: molecular_function def: "Interacting selectively with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb] synonym: "scavenger receptor ligand" NARROW [] xref: GO:0005124 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001427 name: cytokine activity namespace: molecular_function def: "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471] xref: GO:0005125 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001428 name: hematopoietin/interferon-class (D200-domain) cytokine receptor binding namespace: molecular_function synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW [] xref: GO:0005126 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0001429 name: ciliary neurotrophic factor receptor binding namespace: molecular_function def: "Interacting selectively with the ciliary neurotrophic factor receptor." [GOC:ai] synonym: "ciliary neurotrophic factor" NARROW [] synonym: "ciliary neurotrophic factor receptor ligand" NARROW [] xref: GO:0005127 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001430 name: erythropoietin receptor binding namespace: molecular_function def: "Interacting selectively with the erythropoietin receptor." [GOC:ai] synonym: "erythropoietin" NARROW [] synonym: "erythropoietin receptor ligand" NARROW [] xref: GO:0005128 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001431 name: granulocyte macrophage colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively with the granulocyte macrophage colony-stimulating factor receptor." [GOC:ai] synonym: "GM-CSF receptor ligand" NARROW [] synonym: "GMC-SF receptor ligand" NARROW [] synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW [] synonym: "granulocyte-macrophage colony stimulating factor" NARROW [] xref: GO:0005129 is_a: CCO:F0001430 ! erythropoietin receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001432 name: granulocyte colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively with the granulocyte colony-stimulating factor receptor." [GOC:ai] synonym: "G-CSF receptor ligand" EXACT [] synonym: "GC-SF receptor ligand" EXACT [] synonym: "granulocyte colony-stimulating factor" NARROW [] synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW [] xref: GO:0005130 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001433 name: growth hormone receptor binding namespace: molecular_function def: "Interacting selectively with the growth hormone receptor." [GOC:ai] synonym: "growth hormone" NARROW [] synonym: "growth hormone receptor ligand" NARROW [] xref: GO:0005131 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001434 name: interferon-alpha/beta receptor binding namespace: molecular_function def: "Interacting selectively with the interferon-alpha/beta receptor." [GOC:ai] synonym: "interferon-alpha/beta" NARROW [] synonym: "interferon-alpha/beta receptor ligand" NARROW [] xref: GO:0005132 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001435 name: interferon-gamma receptor binding namespace: molecular_function def: "Interacting selectively with the interferon-gamma receptor." [GOC:ai] synonym: "interferon-gamma" NARROW [] synonym: "interferon-gamma receptor ligand" NARROW [] xref: GO:0005133 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001436 name: interleukin-2 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-2 receptor." [GOC:ai] synonym: "IL-2" NARROW [] synonym: "interleukin-2 receptor ligand" NARROW [] xref: GO:0005134 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001437 name: interleukin-3 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-3 receptor." [GOC:ai] synonym: "IL-3" NARROW [] synonym: "interleukin-3 receptor ligand" NARROW [] xref: GO:0005135 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001438 name: interleukin-4 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-4 receptor." [GOC:ai] synonym: "IL-4" NARROW [] synonym: "interleukin-4 receptor ligand" NARROW [] xref: GO:0005136 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001439 name: interleukin-5 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-5 receptor." [GOC:ai] synonym: "IL-5" NARROW [] synonym: "interleukin-5 receptor ligand" NARROW [] xref: GO:0005137 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001440 name: interleukin-6 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-6 receptor." [GOC:ai] synonym: "IL-6" NARROW [] synonym: "interleukin-6 receptor ligand" NARROW [] xref: GO:0005138 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001441 name: interleukin-7 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-7 receptor." [GOC:ai] synonym: "IL-7" NARROW [] synonym: "interleukin-7 receptor ligand" NARROW [] xref: GO:0005139 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001442 name: interleukin-9 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-9 receptor." [GOC:ai] synonym: "IL-9" NARROW [] synonym: "interleukin-9 receptor ligand" NARROW [] xref: GO:0005140 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001443 name: interleukin-10 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-10 receptor." [GOC:ai] synonym: "IL-10" NARROW [] synonym: "interleukin-10 receptor ligand" NARROW [] xref: GO:0005141 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001444 name: interleukin-11 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-11 receptor." [GOC:ai] synonym: "IL-11" NARROW [] synonym: "interleukin-11 receptor ligand" NARROW [] xref: GO:0005142 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001445 name: interleukin-12 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-12 receptor." [GOC:ai] synonym: "IL-12" NARROW [] synonym: "interleukin-12 receptor ligand" NARROW [] xref: GO:0005143 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001446 name: interleukin-13 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-13 receptor." [GOC:ai] synonym: "IL-13" NARROW [] synonym: "interleukin-13 receptor ligand" NARROW [] xref: GO:0005144 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001447 name: interleukin-14 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-14 receptor." [GOC:ai] synonym: "IL-14" NARROW [] synonym: "interleukin-14 receptor ligand" NARROW [] xref: GO:0005145 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001448 name: leukemia inhibitory factor receptor binding namespace: molecular_function def: "Interacting selectively with the leukemia inhibitory factor receptor." [GOC:ai] synonym: "leukemia inhibitory factor" NARROW [] synonym: "leukemia inhibitory factor receptor ligand" NARROW [] xref: GO:0005146 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001449 name: oncostatin-M receptor binding namespace: molecular_function def: "Interacting selectively with the oncostatin-M receptor." [GOC:ai] synonym: "oncostatin-M" NARROW [] synonym: "oncostatin-M receptor ligand" NARROW [] xref: GO:0005147 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001450 name: prolactin receptor binding namespace: molecular_function def: "Interacting selectively with the prolactin receptor." [GOC:ai] synonym: "prolactin" NARROW [] synonym: "prolactin receptor ligand" NARROW [] xref: GO:0005148 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0001451 name: interleukin-1 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-1 receptor." [GOC:go_curators] synonym: "IL-1" NARROW [] synonym: "interleukin-1 receptor ligand" NARROW [] xref: GO:0005149 is_a: CCO:F0001427 ! cytokine activity is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001452 name: interleukin-1, Type I receptor binding namespace: molecular_function def: "Interacting selectively with a Type I interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type I" NARROW [] synonym: "interleukin-1, Type I receptor ligand" NARROW [] xref: GO:0005150 is_a: CCO:F0001451 ! interleukin-1 receptor binding [Term] id: CCO:F0001453 name: interleukin-1, Type II receptor binding namespace: molecular_function def: "Interacting selectively with a Type II interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type II" NARROW [] synonym: "interleukin-1, Type II receptor ligand" NARROW [] xref: GO:0005151 is_a: CCO:F0001451 ! interleukin-1 receptor binding [Term] id: CCO:F0001454 name: interleukin-1 receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc] synonym: "IL-1ra" EXACT [] xref: GO:0005152 is_a: CCO:F0001451 ! interleukin-1 receptor binding is_a: CCO:F0004407 ! fibroblast growth factor receptor antagonist activity [Term] id: CCO:F0001455 name: interleukin-8 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-8 receptor." [GOC:go_curators] synonym: "IL-8" NARROW [] synonym: "interleukin-8 receptor ligand" NARROW [] xref: GO:0005153 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0001456 name: epidermal growth factor receptor binding namespace: molecular_function def: "Interacting selectively with the epidermal growth factor receptor." [GOC:ai] synonym: "EGF" NARROW [] synonym: "EGF receptor binding" EXACT [] synonym: "EGF receptor ligand" NARROW [] synonym: "EGFR binding" EXACT [] synonym: "epidermal growth factor" NARROW [] synonym: "epidermal growth factor receptor ligand" NARROW [] synonym: "TGF-alpha receptor binding" EXACT [] synonym: "TGFalpha receptor binding" EXACT [] synonym: "transforming growth factor alpha" NARROW [] synonym: "transforming growth factor alpha receptor binding" EXACT [] synonym: "transforming growth factor alpha receptor ligand" NARROW [] xref: GO:0005154 xref: GO:0008185 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001457 name: epidermal growth factor receptor activating ligand activity namespace: molecular_function synonym: "EGF receptor activating ligand activity" EXACT [] synonym: "EGFR activating ligand activity" EXACT [] xref: GO:0005155 is_a: CCO:F0001456 ! epidermal growth factor receptor binding [Term] id: CCO:F0001458 name: epidermal growth factor receptor inhibiting ligand activity namespace: molecular_function synonym: "EGF receptor inhibiting ligand activity" EXACT [] synonym: "EGFR inhibiting ligand activity" EXACT [] xref: GO:0005156 is_a: CCO:F0001456 ! epidermal growth factor receptor binding [Term] id: CCO:F0001459 name: macrophage colony stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively with the macrophage colony stimulating factor receptor." [GOC:ai] synonym: "macrophage colony stimulating factor receptor ligand" NARROW [] xref: GO:0005157 is_a: CCO:F0001427 ! cytokine activity is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001460 name: insulin receptor binding namespace: molecular_function def: "Interacting selectively with the insulin receptor." [GOC:ai] synonym: "insulin receptor ligand" NARROW [] xref: GO:0005158 is_a: CCO:F0001407 ! receptor binding is_a: CCO:F0004983 ! protein complex binding [Term] id: CCO:F0001461 name: insulin-like growth factor receptor binding namespace: molecular_function def: "Interacting selectively with the insulin-like growth factor receptor." [GOC:jl] synonym: "IGF receptor binding" EXACT [] synonym: "insulin-like growth factor" NARROW [] synonym: "insulin-like growth factor receptor ligand" NARROW [] xref: GO:0005067 xref: GO:0005159 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001462 name: transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively with the transforming growth factor beta receptor." [GOC:ai] synonym: "activin" RELATED [] synonym: "inhibin" RELATED [] synonym: "TGF-beta receptor binding" EXACT [] synonym: "TGFbeta receptor binding" EXACT [] synonym: "transforming growth factor beta" NARROW [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor anchoring activity" RELATED [] synonym: "transforming growth factor beta receptor ligand" NARROW [] xref: GO:0005160 xref: Reactome:4078 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001463 name: platelet-derived growth factor receptor binding namespace: molecular_function def: "Interacting selectively with the platelet-derived growth factor receptor." [GOC:ai] synonym: "PDGF" NARROW [] synonym: "PDGF receptor binding" EXACT [] synonym: "PDGFR binding" EXACT [] synonym: "platelet-derived growth factor" NARROW [] synonym: "platelet-derived growth factor receptor ligand" NARROW [] xref: GO:0005161 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0001464 name: nerve growth factor receptor binding namespace: molecular_function def: "Interacting selectively with the nerve growth factor receptor." [GOC:ai] synonym: "nerve growth factor receptor ligand" NARROW [] synonym: "neurotrophin" NARROW [] synonym: "NGF receptor binding" EXACT [] xref: GO:0005163 is_a: CCO:F0001466 ! neurotrophin receptor binding [Term] id: CCO:F0001465 name: tumor necrosis factor receptor binding namespace: molecular_function def: "Interacting selectively with the tumor necrosis factor receptor." [GOC:ai] synonym: "TNF receptor binding" EXACT [] synonym: "tumor necrosis factor" NARROW [] synonym: "tumor necrosis factor receptor ligand" NARROW [] xref: GO:0005164 is_a: CCO:F0005041 ! tumor necrosis factor receptor superfamily binding [Term] id: CCO:F0001466 name: neurotrophin receptor binding namespace: molecular_function def: "Interacting selectively with a neurotrophin receptor." [GOC:ai] synonym: "neurotrophin" NARROW [] synonym: "neurotrophin receptor ligand" NARROW [] xref: GO:0005165 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0001467 name: neurotrophin p75 receptor binding namespace: molecular_function def: "Interacting selectively with the neurotrophin p75 receptor." [GOC:ai] synonym: "neurotrophin p75 receptor ligand" NARROW [] xref: GO:0005166 is_a: CCO:F0001466 ! neurotrophin receptor binding [Term] id: CCO:F0001468 name: neurotrophin TRK receptor binding namespace: molecular_function def: "Interacting selectively with a neurotrophin TRK receptor." [GOC:ai] synonym: "neurotrophin TRK receptor ligand" NARROW [] xref: GO:0005167 is_a: CCO:F0001466 ! neurotrophin receptor binding [Term] id: CCO:F0001469 name: neurotrophin TRKA receptor binding namespace: molecular_function def: "Interacting selectively with the neurotrophin TRKA receptor." [GOC:ai] synonym: "neurotrophin TRKA receptor ligand" NARROW [] xref: GO:0005168 is_a: CCO:F0001468 ! neurotrophin TRK receptor binding [Term] id: CCO:F0001470 name: neurotrophin TRKB receptor binding namespace: molecular_function def: "Interacting selectively with the neurotrophin TRKB receptor." [GOC:ai] synonym: "neurotrophin TRKB receptor ligand" NARROW [] xref: GO:0005169 is_a: CCO:F0001468 ! neurotrophin TRK receptor binding [Term] id: CCO:F0001471 name: neurotrophin TRKC receptor binding namespace: molecular_function def: "Interacting selectively with the neurotrophin TRKC receptor." [GOC:ai] synonym: "neurotrophin TRKC receptor ligand" NARROW [] xref: GO:0005170 is_a: CCO:F0001468 ! neurotrophin TRK receptor binding [Term] id: CCO:F0001472 name: hepatocyte growth factor receptor binding namespace: molecular_function def: "Interacting selectively with the hepatocyte growth factor receptor." [GOC:ai] synonym: "hepatocyte growth factor" NARROW [] synonym: "hepatocyte growth factor receptor ligand" NARROW [] synonym: "HGF receptor binding" EXACT [] xref: GO:0005171 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0001473 name: vascular endothelial growth factor receptor binding namespace: molecular_function def: "Interacting selectively with any vascular endothelial growth factor receptor." [GOC:ai] synonym: "vascular endothelial growth factor" NARROW [] synonym: "vascular endothelial growth factor receptor ligand" NARROW [] xref: GO:0005172 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0001474 name: stem cell factor receptor binding namespace: molecular_function def: "Interacting selectively with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217] synonym: "KIT binding" NARROW [] synonym: "SCF" NARROW [] synonym: "SCFR binding" EXACT [] synonym: "stem cell factor" NARROW [] synonym: "stem cell factor receptor ligand" NARROW [] xref: GO:0005173 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0001475 name: CD40 receptor binding namespace: molecular_function def: "Interacting selectively with CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859] xref: GO:0005174 is_a: CCO:F0005041 ! tumor necrosis factor receptor superfamily binding [Term] id: CCO:F0001476 name: CD27 receptor binding namespace: molecular_function def: "Interacting selectively with a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859] xref: GO:0005175 is_a: CCO:F0005041 ! tumor necrosis factor receptor superfamily binding [Term] id: CCO:F0001477 name: ErbB-2 class receptor binding namespace: molecular_function def: "Interacting selectively with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl] synonym: "ErbB-2 class receptor ligand" NARROW [] synonym: "HER2 receptor binding" EXACT [] synonym: "HER2 receptor ligand" NARROW [] synonym: "Neu receptor binding" EXACT [] synonym: "Neu receptor ligand" NARROW [] xref: GO:0005176 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0001478 name: integrin binding namespace: molecular_function def: "Interacting selectively with an integrin." [GOC:ceb] synonym: "integrin ligand" NARROW [] xref: GO:0005178 is_a: CCO:F0001407 ! receptor binding is_a: CCO:F0004983 ! protein complex binding [Term] id: CCO:F0001479 name: hormone activity namespace: molecular_function def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "cAMP generating peptide activity" NARROW [] synonym: "glycopeptide hormone" NARROW [] synonym: "lipopeptide hormone" NARROW [] synonym: "peptide hormone" NARROW [] xref: GO:0005179 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001480 name: luteinizing hormone-releasing factor activity namespace: molecular_function xref: GO:0005183 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0001481 name: neuropeptide hormone activity namespace: molecular_function def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] synonym: "neurohormone" EXACT [] xref: GO:0005184 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0001482 name: neurohypophyseal hormone activity namespace: molecular_function xref: GO:0005185 is_a: CCO:F0001481 ! neuropeptide hormone activity [Term] id: CCO:F0001483 name: pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005186 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001484 name: structural molecule activity namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0005198 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0001485 name: structural constituent of cell wall namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] subset: gosubset_prok xref: GO:0005199 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0001486 name: structural constituent of cytoskeleton namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] subset: gosubset_prok xref: GO:0005200 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0001487 name: extracellular matrix structural constituent namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] subset: gosubset_prok synonym: "extracellular matrix glycoprotein" NARROW [] xref: GO:0005201 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0001488 name: structural constituent of eye lens namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] xref: GO:0005212 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0001489 name: structural constituent of chorion namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chorion." [GOC:mah, GOC:sensu] synonym: "structural constituent of chorion (sensu Insecta)" EXACT [] synonym: "structural protein of chorion (sensu Drosophila)" NARROW [] xref: GO:0005213 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0001490 name: structural constituent of chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of cuticle (sensu Insecta)" EXACT [] xref: GO:0005214 is_a: CCO:F0005657 ! structural constituent of cuticle [Term] id: CCO:F0001491 name: transporter activity namespace: molecular_function def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:ai, GOC:df] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "small-molecule carrier or transporter" RELATED [] xref: GO:0005215 xref: GO:0005478 xref: Reactome:1391 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0001492 name: ion channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729] subset: goslim_generic subset: gosubset_prok xref: GO:0005216 is_a: CCO:F0002557 ! ion transmembrane transporter activity is_a: CCO:F0004269 ! substrate specific channel activity [Term] id: CCO:F0001493 name: intracellular ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0005217 is_a: CCO:F0002733 ! ligand-gated ion channel activity [Term] id: CCO:F0001494 name: intracellular ligand-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0005218 is_a: CCO:F0001493 ! intracellular ligand-gated ion channel activity is_a: CCO:F0002735 ! calcium-release channel activity [Term] id: CCO:F0001495 name: ryanodine-sensitive calcium-release channel activity namespace: molecular_function synonym: "caffeine-sensitive calcium-release channel" RELATED [] synonym: "ryanodine receptor" NARROW [] xref: GO:0005219 is_a: CCO:F0001494 ! intracellular ligand-gated calcium channel activity [Term] id: CCO:F0001496 name: inositol 1,4,5-triphosphate-sensitive calcium-release channel activity namespace: molecular_function xref: GO:0005220 is_a: CCO:F0001493 ! intracellular ligand-gated ion channel activity is_a: CCO:F0002735 ! calcium-release channel activity [Term] id: CCO:F0001497 name: intracellular cyclic nucleotide activated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] xref: GO:0005221 is_a: CCO:F0001493 ! intracellular ligand-gated ion channel activity is_a: CCO:F0001524 ! cation channel activity is_a: CCO:F0006017 ! cyclic nucleotide-gated ion channel activity [Term] id: CCO:F0001498 name: intracellular cAMP activated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT [] synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT [] synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT [] synonym: "intracellular cyclic AMP activated cation channel activity" EXACT [] xref: GO:0005222 is_a: CCO:F0001497 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: CCO:F0001499 name: intracellular cGMP activated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] xref: GO:0005223 is_a: CCO:F0001497 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: CCO:F0001500 name: ATP-binding and phosphorylation-dependent chloride channel activity namespace: molecular_function xref: GO:0005224 is_a: CCO:F0001493 ! intracellular ligand-gated ion channel activity is_a: CCO:F0001522 ! chloride channel activity [Term] id: CCO:F0001501 name: volume-sensitive anion channel activity namespace: molecular_function synonym: "volume-regulated channel" BROAD [] xref: GO:0005225 is_a: CCO:F0001521 ! anion channel activity [Term] id: CCO:F0001502 name: calcium activated cation channel activity namespace: molecular_function def: "Catalysis of the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] synonym: "intracellular calcium-activated potassium channel" NARROW [] synonym: "polycystin" NARROW [] xref: GO:0005227 is_a: CCO:F0001524 ! cation channel activity [Term] id: CCO:F0001503 name: intracellular sodium activated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167] xref: GO:0005228 is_a: CCO:F0001526 ! potassium channel activity is_a: CCO:F0004270 ! ion gated channel activity [Term] id: CCO:F0001504 name: intracellular calcium activated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] xref: GO:0005229 is_a: CCO:F0001522 ! chloride channel activity is_a: CCO:F0004270 ! ion gated channel activity [Term] id: CCO:F0001505 name: extracellular ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0005230 is_a: CCO:F0002733 ! ligand-gated ion channel activity [Term] id: CCO:F0001506 name: excitatory extracellular ligand-gated ion channel activity namespace: molecular_function subset: gosubset_prok xref: GO:0005231 is_a: CCO:F0001505 ! extracellular ligand-gated ion channel activity [Term] id: CCO:F0001507 name: serotonin-activated cation-selective channel activity namespace: molecular_function comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'serotonin receptor activity ; GO:0004993'. synonym: "5-hydroxytryptamine-gated receptor-channel" EXACT [] xref: GO:0005232 is_a: CCO:F0001506 ! excitatory extracellular ligand-gated ion channel activity is_a: CCO:F0001524 ! cation channel activity [Term] id: CCO:F0001508 name: extracellular-glutamate-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. subset: gosubset_prok xref: GO:0005234 is_a: CCO:F0001506 ! excitatory extracellular ligand-gated ion channel activity [Term] id: CCO:F0001509 name: inhibitory extracellular ligand-gated ion channel activity namespace: molecular_function xref: GO:0005237 is_a: CCO:F0001505 ! extracellular ligand-gated ion channel activity [Term] id: CCO:F0001510 name: inward rectifier potassium channel activity namespace: molecular_function subset: gosubset_prok xref: GO:0005242 is_a: CCO:F0001517 ! voltage-gated potassium channel activity [Term] id: CCO:F0001511 name: gap junction channel activity namespace: molecular_function def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729] synonym: "connexin" RELATED [] synonym: "innexin" NARROW [] synonym: "innexin channel activity" EXACT [] synonym: "intercellular channel" BROAD [] xref: GO:0005243 xref: GO:0015285 xref: GO:0015286 is_a: CCO:F0004262 ! wide pore channel activity [Term] id: CCO:F0001512 name: voltage-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "voltage gated ion channel activity" EXACT [] synonym: "voltage-dependent ion channel activity" EXACT [] xref: GO:0005244 is_a: CCO:F0001492 ! ion channel activity is_a: CCO:F0004264 ! voltage-gated channel activity [Term] id: CCO:F0001513 name: voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] synonym: "depolarisation-activated calcium channel" BROAD [] synonym: "depolarisation-activated voltage-gated calcium channel" EXACT [] synonym: "depolarization-activated calcium channel" BROAD [] synonym: "depolarization-activated voltage gated calcium channel activity" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT [] synonym: "voltage gated calcium channel activity" EXACT [] synonym: "voltage-dependent calcium channel activity" EXACT [] synonym: "voltage-gated calcium ion channel activity" EXACT [] synonym: "voltage-sensitive calcium channel" EXACT [] xref: GO:0005245 xref: GO:0010173 is_a: CCO:F0001525 ! calcium channel activity is_a: CCO:F0004274 ! voltage-gated cation channel activity [Term] id: CCO:F0001514 name: calcium channel regulator activity namespace: molecular_function xref: GO:0005246 is_a: CCO:F0003086 ! channel regulator activity [Term] id: CCO:F0001515 name: voltage-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "voltage gated chloride channel activity" EXACT [] synonym: "voltage-dependent chloride channel activity" EXACT [] xref: GO:0005247 is_a: CCO:F0001522 ! chloride channel activity is_a: CCO:F0001822 ! voltage-gated anion channel activity [Term] id: CCO:F0001516 name: voltage-gated sodium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated sodium channel activity" EXACT [] synonym: "voltage-dependent sodium channel activity" EXACT [] synonym: "voltage-gated sodium ion channel activity" EXACT [] synonym: "voltage-sensitive sodium channel" EXACT [] xref: GO:0005248 is_a: CCO:F0001527 ! sodium channel activity is_a: CCO:F0004274 ! voltage-gated cation channel activity [Term] id: CCO:F0001517 name: voltage-gated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "voltage gated potassium channel activity" EXACT [] synonym: "voltage-dependent potassium channel activity" EXACT [] synonym: "voltage-gated potassium ion channel activity" EXACT [] synonym: "voltage-sensitive potassium channel" EXACT [] xref: GO:0005249 is_a: CCO:F0001526 ! potassium channel activity is_a: CCO:F0004274 ! voltage-gated cation channel activity [Term] id: CCO:F0001518 name: A-type (transient outward) potassium channel activity namespace: molecular_function xref: GO:0005250 is_a: CCO:F0002728 ! outward rectifier potassium channel activity [Term] id: CCO:F0001519 name: delayed rectifier potassium channel activity namespace: molecular_function xref: GO:0005251 is_a: CCO:F0001517 ! voltage-gated potassium channel activity [Term] id: CCO:F0001520 name: open rectifier potassium channel activity namespace: molecular_function xref: GO:0005252 is_a: CCO:F0001517 ! voltage-gated potassium channel activity [Term] id: CCO:F0001521 name: anion channel activity namespace: molecular_function def: "Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0005253 is_a: CCO:F0001492 ! ion channel activity is_a: CCO:F0001962 ! anion transmembrane transporter activity [Term] id: CCO:F0001522 name: chloride channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of an chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0005254 is_a: CCO:F0001521 ! anion channel activity [Term] id: CCO:F0001523 name: channel-conductance-controlling ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels." [EC:3.6.3.49] synonym: "ATP phosphohydrolase (channel-conductance-controlling)" EXACT [EC:3.6.3.49] synonym: "cystic fibrosis transmembrane conductance regulator" NARROW [] synonym: "cystic-fibrosis membrane-conductance-regulating protein activity" NARROW [EC:3.6.3.49] xref: EC:3.6.3.49 xref: GO:0005260 xref: MetaCyc:3.6.3.49-RXN is_a: CCO:F0001522 ! chloride channel activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0001524 name: cation channel activity namespace: molecular_function def: "Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "cation diffusion facilitator activity" EXACT [] synonym: "nonselective cation channel activity" EXACT [] xref: GO:0005261 xref: GO:0015281 xref: GO:0015338 is_a: CCO:F0001492 ! ion channel activity is_a: CCO:F0001835 ! cation transmembrane transporter activity is_a: CCO:F0006258 ! metal ion transmembrane transporter activity [Term] id: CCO:F0001525 name: calcium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of an calcium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0005262 xref: Reactome:13088 is_a: CCO:F0001524 ! cation channel activity [Term] id: CCO:F0001526 name: potassium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0005267 is_a: CCO:F0001524 ! cation channel activity [Term] id: CCO:F0001527 name: sodium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0005272 is_a: CCO:F0001524 ! cation channel activity [Term] id: CCO:F0001528 name: allantoin uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1] synonym: "allantoin permease activity" RELATED [] synonym: "allantoin/allantoate transporter" BROAD [] xref: GO:0005274 xref: GO:0015206 is_a: CCO:F0002815 ! nucleobase:cation symporter activity is_a: CCO:F0002943 ! uptake transmembrane transporter activity [Term] id: CCO:F0001529 name: amine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "amine/amide/polyamine channel activity" BROAD [] synonym: "amine/polyamine transmembrane transporter activity" EXACT [] synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] xref: GO:0005275 xref: GO:0005279 is_a: CCO:F0004251 ! active transmembrane transporter activity [Term] id: CCO:F0001530 name: hydrogen:vesicular amine antiporter activity namespace: molecular_function xref: GO:0005276 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0002748 ! solute:hydrogen antiporter activity [Term] id: CCO:F0001531 name: acetylcholine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] xref: GO:0005277 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0001559 ! neurotransmitter transporter activity [Term] id: CCO:F0001532 name: acetylcholine:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13] synonym: "acetylcholine:proton antiporter" EXACT [] xref: GO:0005278 is_a: CCO:F0001531 ! acetylcholine transmembrane transporter activity is_a: CCO:F0002748 ! solute:hydrogen antiporter activity [Term] id: CCO:F0001533 name: hydrogen:amino acid symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai] subset: gosubset_prok synonym: "cation/amino acid symporter" BROAD [] xref: GO:0005280 is_a: CCO:F0001608 ! cation:amino acid symporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity [Term] id: CCO:F0001534 name: sodium:amino acid symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "sodium/amino acid transporter" EXACT [] synonym: "sodium/excitatory amino acid cotransporter activity" EXACT [] synonym: "sodium/excitatory amino acid symporter activity" EXACT [] synonym: "sodium:amino acid transporter activity" EXACT [] synonym: "threonine/serine:sodium symporter activity" NARROW [] xref: GO:0005283 xref: GO:0005285 is_a: CCO:F0001571 ! organic acid:sodium symporter activity is_a: CCO:F0001608 ! cation:amino acid symporter activity [Term] id: CCO:F0001535 name: insulin-activated sodium:amino acid symporter activity namespace: molecular_function synonym: "insulin-activated sodium/amino acid transporter activity" EXACT [] synonym: "insulin-activated sodium:amino acid transporter activity" EXACT [] xref: GO:0005284 is_a: CCO:F0001534 ! sodium:amino acid symporter activity [Term] id: CCO:F0001536 name: high affinity basic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity basic amino acid transporter activity" BROAD [] xref: GO:0005287 is_a: CCO:F0002651 ! basic amino acid transmembrane transporter activity [Term] id: CCO:F0001537 name: high affinity arginine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arginine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity arginine transporter activity" BROAD [] xref: GO:0005289 is_a: CCO:F0001536 ! high affinity basic amino acid transmembrane transporter activity is_a: CCO:F0002655 ! arginine transmembrane transporter activity [Term] id: CCO:F0001538 name: L-histidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-histidine transporter activity" BROAD [] xref: GO:0005290 is_a: CCO:F0002651 ! basic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0001539 name: high affinity L-histidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity histidine permease activity" RELATED [] xref: GO:0005291 is_a: CCO:F0001536 ! high affinity basic amino acid transmembrane transporter activity is_a: CCO:F0001538 ! L-histidine transmembrane transporter activity [Term] id: CCO:F0001540 name: high affinity lysine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lysine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity lysine transporter activity" BROAD [] xref: GO:0005292 is_a: CCO:F0001536 ! high affinity basic amino acid transmembrane transporter activity is_a: CCO:F0002663 ! L-lysine transmembrane transporter activity [Term] id: CCO:F0001541 name: neutral L-amino acid secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] subset: gosubset_prok synonym: "neutral L-amino acid porter activity" RELATED [] xref: GO:0005294 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0001542 name: neutral amino acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1] synonym: "neutral amino acid-sodium cotransporter" BROAD [] synonym: "sodium/neutral amino acid transporter" BROAD [] xref: GO:0005282 xref: GO:0005295 is_a: CCO:F0001534 ! sodium:amino acid symporter activity is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity [Term] id: CCO:F0001543 name: hydrogen:proline symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai] synonym: "hydrogen/proline transporter" BROAD [] xref: GO:0005297 is_a: CCO:F0001533 ! hydrogen:amino acid symporter activity is_a: CCO:F0002667 ! L-proline transmembrane transporter activity [Term] id: CCO:F0001544 name: proline:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1] subset: gosubset_prok synonym: "sodium/proline symporter" EXACT [] xref: GO:0005298 is_a: CCO:F0001534 ! sodium:amino acid symporter activity is_a: CCO:F0002667 ! L-proline transmembrane transporter activity [Term] id: CCO:F0001545 name: high-affinity tryptophan transmembrane transporter activity namespace: molecular_function def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:mtg_transport, ISBN:0815340729] synonym: "high-affinity tryptophan transporter activity" BROAD [] xref: GO:0005300 is_a: CCO:F0002670 ! L-tryptophan transmembrane transporter activity [Term] id: CCO:F0001546 name: L-tyrosine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-tyrosine permease activity" EXACT [] synonym: "L-tyrosine transporter activity" BROAD [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] xref: GO:0005302 xref: GO:0015508 is_a: CCO:F0002650 ! aromatic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0001547 name: L-valine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "L-valine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] xref: GO:0005304 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0001548 name: choline:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5] synonym: "sodium/choline symporter" EXACT [] xref: GO:0005307 is_a: CCO:F0002691 ! choline transmembrane transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001549 name: creatine transporter activity namespace: molecular_function def: "Enables the directed movement of creatine into, out of, within or between cells. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] xref: GO:0005308 is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0001550 name: creatine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4] synonym: "sodium/chloride-dependent creatine transporter" BROAD [] xref: GO:0005309 is_a: CCO:F0001549 ! creatine transporter activity is_a: CCO:F0001560 ! neurotransmitter:sodium symporter activity [Term] id: CCO:F0001551 name: dicarboxylic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] subset: gosubset_prok synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] synonym: "dicarboxylate carrier" NARROW [] synonym: "dicarboxylic acid permease activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: GO:0005310 xref: GO:0005312 xref: GO:0015365 is_a: CCO:F0006282 ! carboxylic acid transmembrane transporter activity [Term] id: CCO:F0001552 name: L-glutamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-glutamate transporter activity" BROAD [] xref: GO:0005313 is_a: CCO:F0002649 ! acidic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0001553 name: high-affinity glutamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in)." [TC:2.A.3.10.5] synonym: "high-affinity glutamate transporter activity" BROAD [] xref: GO:0005314 is_a: CCO:F0001552 ! L-glutamate transmembrane transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001554 name: inorganic phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] subset: gosubset_prok xref: GO:0005315 xref: GO:0005317 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0001555 name: high affinity inorganic phosphate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in)." [TC:2.A.20.2.2] synonym: "sodium/phosphate cotransporter" BROAD [] xref: GO:0005316 is_a: CCO:F0001613 ! sodium:phosphate symporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001556 name: lipid transporter activity namespace: molecular_function def: "Enables the directed movement of lipids into, out of, within or between cells." [GOC:ai] subset: gosubset_prok synonym: "apolipoprotein" RELATED [] synonym: "high-density lipoprotein" RELATED [] synonym: "lipophorin" NARROW [] synonym: "low-density lipoprotein" RELATED [] synonym: "very-low-density lipoprotein" RELATED [] xref: GO:0005319 xref: Reactome:7042 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0001557 name: long-chain fatty acid transporter activity namespace: molecular_function def: "Enables the directed movement of long-chain fatty acids into, out of, within or between cells. Long-chain fatty acids have a chain length of greater than 12 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "plasma membrane long-chain fatty acid transporter" NARROW [] xref: GO:0005324 is_a: CCO:F0002713 ! fatty acid transporter activity [Term] id: CCO:F0001558 name: peroxisomal fatty acyl CoA transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes." [EC:3.6.3.47] synonym: "ATP phosphohydrolase (fatty-acyl-CoA-transporting)" EXACT [EC:3.6.3.47] synonym: "fatty-acyl-CoA-transporting ATPase" BROAD [] xref: EC:3.6.3.47 xref: GO:0005325 xref: GO:0008562 is_a: CCO:F0001557 ! long-chain fatty acid transporter activity is_a: CCO:F0002970 ! fatty acyl CoA transporter activity [Term] id: CCO:F0001559 name: neurotransmitter transporter activity namespace: molecular_function def: "Enables the directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: gosubset_prok xref: GO:0005326 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0001560 name: neurotransmitter:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] subset: gosubset_prok synonym: "sodium/neurotransmitter symporter" EXACT [] xref: GO:0005328 is_a: CCO:F0001559 ! neurotransmitter transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001561 name: dopamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] xref: GO:0005329 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0001562 name: dopamine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in)." [TC:2.A.22.1.3] synonym: "sodium/dopamine symporter" EXACT [] xref: GO:0005330 is_a: CCO:F0001560 ! neurotransmitter:sodium symporter activity is_a: CCO:F0001561 ! dopamine transmembrane transporter activity [Term] id: CCO:F0001563 name: gamma-aminobutyric acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2] comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'. synonym: "4-aminobutanoate:sodium symporter activity" EXACT [] synonym: "4-aminobutyrate:sodium symporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" EXACT [] synonym: "GABA:sodium symporter activity" EXACT [] synonym: "sodium/chloride-dependent GABA transporter" RELATED [] xref: GO:0005332 is_a: CCO:F0001534 ! sodium:amino acid symporter activity is_a: CCO:F0002659 ! L-gamma-aminobutyric acid transmembrane transporter activity [Term] id: CCO:F0001564 name: norepinephrine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of norepinephrine from one side of the membrane to the other. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "levarterenol transporter" EXACT [] synonym: "noradrenaline transporter" EXACT [] xref: GO:0005333 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0001559 ! neurotransmitter transporter activity [Term] id: CCO:F0001565 name: norephinephrine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in)." [TC:2.A.22.1.2] synonym: "noradrenaline:sodium symporter activity" EXACT [] synonym: "sodium/norepinephrine symporter" EXACT [] xref: GO:0005334 is_a: CCO:F0001560 ! neurotransmitter:sodium symporter activity is_a: CCO:F0001564 ! norepinephrine transmembrane transporter activity [Term] id: CCO:F0001566 name: serotonin:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) = serotonin(in) + Na+(in)." [TC:2.A.22.1.1] synonym: "sodium/serotonin symporter" EXACT [] xref: GO:0005335 xref: GO:0005336 is_a: CCO:F0001560 ! neurotransmitter:sodium symporter activity [Term] id: CCO:F0001567 name: nucleoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "intracellular nucleoside transmembrane transporter activity" NARROW [] xref: GO:0005337 is_a: CCO:F0003026 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: CCO:F0001568 name: nucleotide-sugar transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926] xref: GO:0005338 xref: GO:0005339 is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity [Term] id: CCO:F0001569 name: nucleotide-sulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport] synonym: "nucleotide-sulphate transporter activity" EXACT [] xref: GO:0005340 xref: GO:0005341 is_a: CCO:F0002594 ! sulfate transmembrane transporter activity [Term] id: CCO:F0001570 name: organic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005342 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0001571 name: organic acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1] subset: gosubset_prok synonym: "sodium/chloride-dependent organic acid cotransporter" NARROW [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: GO:0005343 is_a: CCO:F0001570 ! organic acid transmembrane transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001572 name: oxygen transporter activity namespace: molecular_function def: "Enables the directed movement of oxygen into, out of, within or between cells." [GOC:ai] subset: gosubset_prok synonym: "globin" NARROW [] synonym: "hemerythrin" NARROW [] synonym: "hemocyanin" NARROW [] synonym: "oxygen-carrying" NARROW [] xref: GO:0005344 xref: GO:0015033 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0001573 name: purine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005345 is_a: CCO:F0002677 ! nucleobase transmembrane transporter activity [Term] id: CCO:F0001574 name: purine ribonucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] xref: GO:0005346 is_a: CCO:F0002687 ! purine nucleotide transmembrane transporter activity [Term] id: CCO:F0001575 name: ATP transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai] xref: GO:0005347 xref: GO:0005348 is_a: CCO:F0000061 ! adenine nucleotide transmembrane transporter activity [Term] id: CCO:F0001576 name: pyrimidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of pyrimidines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0005350 is_a: CCO:F0002677 ! nucleobase transmembrane transporter activity [Term] id: CCO:F0001577 name: sugar:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-] subset: gosubset_prok synonym: "cation/sugar symporter activity" BROAD [] synonym: "hydrogen:sugar symporter activity" EXACT [] synonym: "hydrogen:sugar transporter activity" BROAD [] synonym: "proton:sugar symporter activity" EXACT [] synonym: "sugar porter activity" RELATED [] synonym: "sugar transporter" BROAD [] synonym: "sugar:hydrogen ion symporter activity" EXACT [] xref: GO:0005351 xref: GO:0005403 is_a: CCO:F0001605 ! cation:sugar symporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0008062 ! sugar transmembrane transporter activity [Term] id: CCO:F0001578 name: alpha-glucoside:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11] synonym: "general alpha-glucoside transporter activity" BROAD [] synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT [] synonym: "general alpha-glucoside:proton symporter activity" EXACT [] xref: GO:0005352 is_a: CCO:F0001605 ! cation:sugar symporter activity is_a: CCO:F0002628 ! alpha-glucoside transmembrane transporter activity [Term] id: CCO:F0001579 name: fructose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "fructose permease activity" EXACT [] synonym: "fructose porter activity" EXACT [] xref: GO:0005353 xref: GO:0015585 xref: GO:0019192 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0001580 name: galactose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of galactose from one side of the membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] xref: GO:0005354 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0001581 name: glucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] synonym: "glucose permease activity" EXACT [] synonym: "lactose/glucose efflux transporter activity" NARROW [] xref: GO:0005355 xref: GO:0015579 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0001582 name: hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "hydrogen:glucose transporter activity" RELATED [] xref: GO:0005356 is_a: CCO:F0001581 ! glucose transmembrane transporter activity is_a: CCO:F0002404 ! hexose:hydrogen symporter activity [Term] id: CCO:F0001583 name: constitutive hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constituitive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "constitutive hydrogen/glucose transporter" EXACT [] synonym: "constitutive hydrogen:glucose transporter activity" RELATED [] xref: GO:0005357 is_a: CCO:F0001582 ! hydrogen:glucose symporter activity [Term] id: CCO:F0001584 name: high-affinity hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constituitive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity hydrogen/glucose transporter" EXACT [] synonym: "high-affinity hydrogen:glucose transporter activity" RELATED [] xref: GO:0005358 is_a: CCO:F0001582 ! hydrogen:glucose symporter activity [Term] id: CCO:F0001585 name: low-affinity hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "low-affinity hydrogen/glucose transporter" EXACT [] synonym: "low-affinity hydrogen:glucose transporter activity" RELATED [] xref: GO:0005359 is_a: CCO:F0001582 ! hydrogen:glucose symporter activity [Term] id: CCO:F0001586 name: insulin-responsive hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen/glucose transporter" RELATED [] xref: GO:0005360 is_a: CCO:F0001582 ! hydrogen:glucose symporter activity [Term] id: CCO:F0001587 name: transepithelial hydrogen:glucose symporter activity namespace: molecular_function synonym: "transepithelial hydrogen/glucose transporter" EXACT [] synonym: "transepithelial hydrogen:glucose transporter activity" RELATED [] xref: GO:0005361 is_a: CCO:F0001582 ! hydrogen:glucose symporter activity [Term] id: CCO:F0001588 name: low-affinity glucose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-] synonym: "low-affinity glucose-sodium cotransporter" BROAD [] xref: GO:0005362 is_a: CCO:F0001606 ! glucose:sodium symporter activity [Term] id: CCO:F0001589 name: maltose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "maltose porter activity" EXACT [] xref: GO:0005363 xref: GO:0015581 is_a: CCO:F0002628 ! alpha-glucoside transmembrane transporter activity is_a: CCO:F0002631 ! disaccharide transmembrane transporter activity [Term] id: CCO:F0001590 name: maltose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10] synonym: "hydrogen/maltose transporter" NARROW [] synonym: "maltose permease" BROAD [] synonym: "maltose:proton symporter" EXACT [] xref: GO:0005364 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0001589 ! maltose transmembrane transporter activity [Term] id: CCO:F0001591 name: myo-inositol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of myo-inositol from one side of the membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] subset: gosubset_prok synonym: "vitamin Bh transporter activity" EXACT [] xref: GO:0005365 is_a: CCO:F0002643 ! polyol transmembrane transporter activity [Term] id: CCO:F0001592 name: myo-inositol:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8] synonym: "hydrogen/myo-inositol transporter" BROAD [] synonym: "myo-inositol:proton symporter" EXACT [] xref: GO:0005366 is_a: CCO:F0001591 ! myo-inositol transmembrane transporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity [Term] id: CCO:F0001593 name: myo-inositol:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-] synonym: "myo-inositol-sodium cotransporter" BROAD [] xref: GO:0005367 is_a: CCO:F0001591 ! myo-inositol transmembrane transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001594 name: taurine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai] subset: gosubset_prok xref: GO:0005368 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0001595 name: taurine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3] synonym: "sodium/chloride-dependent taurine transporter" BROAD [] xref: GO:0005369 is_a: CCO:F0001560 ! neurotransmitter:sodium symporter activity is_a: CCO:F0001571 ! organic acid:sodium symporter activity is_a: CCO:F0001594 ! taurine transmembrane transporter activity [Term] id: CCO:F0001596 name: tricarboxylate secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "citrate carrier" EXACT [] synonym: "tricarboxylate carrier activity" EXACT [] xref: GO:0005370 xref: GO:0005371 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0001597 name: water transporter activity namespace: molecular_function def: "Enables the directed movement of water (H2O) into, out of, within or between cells." [GOC:ai] subset: gosubset_prok xref: GO:0005372 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0001598 name: copper ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "intracellular copper ion transporter" NARROW [] synonym: "plasma membrane copper transporter" NARROW [] xref: GO:0005375 xref: GO:0005378 xref: GO:0005379 xref: GO:0005380 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0001599 name: iron ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "iron transporter" EXACT [] synonym: "multicopper ferroxidase iron transport mediator activity" RELATED [] synonym: "transmembrane iron ion permease activity" EXACT [] synonym: "transmembrane iron permease activity" EXACT [] synonym: "zinc, iron permease activity" RELATED [] xref: GO:0005381 xref: GO:0005382 xref: GO:0016033 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0001600 name: manganese ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:df] subset: gosubset_prok xref: GO:0005384 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0001601 name: zinc ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:df] subset: gosubset_prok synonym: "cobalt, zinc uptake permease activity" NARROW [] synonym: "zinc, cadmium uptake permease activity" NARROW [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] synonym: "zinc, iron permease activity" NARROW [] xref: GO:0005385 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0001602 name: calcium-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (Ca2+-transporting)" EXACT [EC:3.6.3.8] synonym: "Ca(2+)-transporting ATPase activity" EXACT [EC:3.6.3.8] synonym: "Ca2+-pumping ATPase activity" EXACT [EC:3.6.3.8] synonym: "Ca2+-transporting ATPase activity" EXACT [EC:3.6.3.8] synonym: "calcium ABC transporter" NARROW [] synonym: "calcium efflux ATPase" NARROW [] synonym: "calcium pump" BROAD [] synonym: "calcium transporting ATPase activity" EXACT [] synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:3.6.3.8] synonym: "plasma membrane Ca-ATPase" NARROW [EC:3.6.3.8] synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [EC:3.6.3.8] synonym: "sarcoplasmic reticulum ATPase" NARROW [] xref: EC:3.6.3.8 xref: GO:0005388 xref: MetaCyc:3.6.3.8-RXN is_a: CCO:F0002565 ! calcium ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: CCO:F0004186 ! cation-transporting ATPase activity [Term] id: CCO:F0001603 name: sodium:potassium-exchanging ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "(Na+ + K+)-activated ATPase activity" EXACT [EC:3.6.3.9] synonym: "(Na+ + K+)-ATPase activity" EXACT [EC:3.6.3.9] synonym: "ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [EC:3.6.3.9] synonym: "Na(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+,K+ pump" RELATED [EC:3.6.3.9] synonym: "Na+,K+-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+/K+-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na,K-activated ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na,K-pump" RELATED [EC:3.6.3.9] synonym: "sodium pump" BROAD [] synonym: "sodium/potassium-exchanging ATPase activity" EXACT [] synonym: "sodium/potassium-transporting ATPase activity" EXACT [EC:3.6.3.9] synonym: "sodium:potassium exchanging ATPase activity" EXACT [] xref: EC:3.6.3.9 xref: GO:0005391 xref: MetaCyc:3.6.3.9-RXN is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0001604 name: eye pigment precursor transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1] xref: GO:0005395 is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0001605 name: cation:sugar symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai] subset: gosubset_prok synonym: "cation/sugar symporter" EXACT [] synonym: "sugar:cation symporter activity" EXACT [] xref: GO:0005402 is_a: CCO:F0002743 ! solute:cation symporter activity [Term] id: CCO:F0001606 name: glucose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] synonym: "sodium/glucose symporter" EXACT [] xref: GO:0005412 is_a: CCO:F0001581 ! glucose transmembrane transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001607 name: nucleoside:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "nucleoside-sodium cotransporter" BROAD [] synonym: "sodium-dependent nucleoside transporter" BROAD [] xref: GO:0005415 xref: GO:0008522 is_a: CCO:F0001567 ! nucleoside transmembrane transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001608 name: cation:amino acid symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai] subset: gosubset_prok synonym: "cation/amino acid symporter" EXACT [] xref: GO:0005416 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0002743 ! solute:cation symporter activity [Term] id: CCO:F0001609 name: proton-dependent oligopeptide secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544] subset: gosubset_prok synonym: "hydrogen/oligopeptide symporter" RELATED [] synonym: "proton-dependent oligopeptide transporter activity" EXACT [] xref: GO:0005427 is_a: CCO:F0002767 ! secondary active oligopeptide transmembrane transporter activity [Term] id: CCO:F0001610 name: chromaffin granule amine transmembrane transporter activity namespace: molecular_function xref: GO:0005429 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0001611 name: synaptic vesicle amine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of amines across synaptic vesicle membranes." [GOC:ai] xref: GO:0005430 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0001612 name: calcium:sodium antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [UniProtKB:P70414] subset: gosubset_prok synonym: "mitochondrial sodium/calcium ion exchange" RELATED [] synonym: "sodium/calcium exchanger" EXACT [] synonym: "sodium:calcium exchange" RELATED [] xref: GO:0005432 is_a: CCO:F0002795 ! calcium:cation antiporter activity [Term] id: CCO:F0001613 name: sodium:phosphate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai] subset: gosubset_prok synonym: "sodium/phosphate symporter" EXACT [] xref: GO:0005436 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0001614 name: monovalent cation:proton antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai] subset: gosubset_prok xref: GO:0005451 is_a: CCO:F0002559 ! hydrogen ion transmembrane transporter activity is_a: CCO:F0002886 ! cation:cation antiporter activity [Term] id: CCO:F0001615 name: inorganic anion exchanger activity namespace: molecular_function xref: GO:0005452 is_a: CCO:F0002805 ! anion exchanger activity [Term] id: CCO:F0001616 name: CMP-sialic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a CMP-sialic acid from one side of the membrane to the other. CMP-sialic acid is a substance composed of sialic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0005456 is_a: CCO:F0002642 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: CCO:F0001617 name: GDP-fucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0005457 is_a: CCO:F0002642 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: CCO:F0001618 name: GDP-mannose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a GDP-mannose from one side of the membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0005458 is_a: CCO:F0002642 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: CCO:F0001619 name: UDP-galactose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0005459 is_a: CCO:F0002642 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: CCO:F0001620 name: UDP-glucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-glucose from one side of the membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0005460 is_a: CCO:F0002642 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: CCO:F0001621 name: UDP-glucuronic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-glucuronic acid from one side of the membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0005461 xref: Reactome:15054 is_a: CCO:F0002642 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: CCO:F0001622 name: UDP-N-acetylglucosamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0005462 is_a: CCO:F0002642 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: CCO:F0001623 name: UDP-N-acetylgalactosamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0005463 is_a: CCO:F0002642 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: CCO:F0001624 name: UDP-xylose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] xref: GO:0005464 is_a: CCO:F0002642 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: CCO:F0001625 name: succinate:fumarate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1] xref: GO:0005469 is_a: CCO:F0002615 ! fumarate transmembrane transporter activity is_a: CCO:F0002618 ! succinate transmembrane transporter activity is_a: CCO:F0002746 ! antiporter activity [Term] id: CCO:F0001626 name: ATP:ADP antiporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1] subset: gosubset_prok synonym: "adenine nucleotide translocase" EXACT [] synonym: "ADP/ATP translocase" EXACT [] synonym: "ATP/ADP exchange" EXACT [] synonym: "ATP/ADP exchanger" EXACT [] xref: GO:0005349 xref: GO:0005471 is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0001627 name: FAD carrier activity namespace: molecular_function synonym: "flavin adenine dinucleotide carrier activity" EXACT [] synonym: "flavin-adenine dinucleotide carrier activity" EXACT [] xref: GO:0005472 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0001628 name: carnitine:acyl carnitine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458] synonym: "carnitine/acyl carnitine carrier activity" EXACT [] synonym: "carnitine:acyl carnitine carrier activity" EXACT [] synonym: "fatty acyl carnitine carrier" EXACT [] xref: GO:0005476 is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0001629 name: pyruvate secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "pyruvate carrier activity" RELATED [] xref: GO:0005477 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity is_a: CCO:F0008022 ! pyruvate transmembrane transporter activity [Term] id: CCO:F0001630 name: soluble NSF attachment protein activity namespace: molecular_function def: "Interacting selectively with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857] synonym: "SNAP" EXACT [] xref: GO:0005483 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001631 name: SNAP receptor activity namespace: molecular_function def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] synonym: "Q-SNARE activity" NARROW [] synonym: "R-SNARE activity" NARROW [] synonym: "SNAP-25" NARROW [] synonym: "SNARE" EXACT [] synonym: "t-SNARE activity" NARROW [] synonym: "v-SNARE activity" NARROW [] xref: GO:0005484 xref: GO:0005485 xref: GO:0005486 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001632 name: nucleocytoplasmic transporter activity namespace: molecular_function def: "Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai] xref: GO:0005487 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0001633 name: binding namespace: molecular_function def: "The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "ligand" NARROW [] xref: GO:0005488 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0001634 name: steroid binding namespace: molecular_function def: "Interacting selectively with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok xref: GO:0005496 is_a: CCO:F0001816 ! lipid binding [Term] id: CCO:F0001635 name: androgen binding namespace: molecular_function def: "Interacting selectively with any androgen, male sex hormones." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0005497 is_a: CCO:F0001634 ! steroid binding is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0001636 name: sterol carrier activity namespace: molecular_function subset: gosubset_prok xref: GO:0005498 is_a: CCO:F0005049 ! sterol binding [Term] id: CCO:F0001637 name: vitamin D binding namespace: molecular_function def: "Interacting selectively with vitamin D, a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the human bloodstream. Vitamin D is also known as calciferol and five different forms are known, including ergocalciferol and cholecalciferol." [GOC:ai] synonym: "calciferol binding" EXACT [] synonym: "cholecalciferol binding" NARROW [] synonym: "ergocalciferol binding" NARROW [] xref: GO:0005499 is_a: CCO:F0001634 ! steroid binding is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0001638 name: juvenile hormone binding namespace: molecular_function def: "Interacting selectively with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005500 is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0001639 name: retinoid binding namespace: molecular_function def: "Interacting selectively with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005501 is_a: CCO:F0004189 ! isoprenoid binding [Term] id: CCO:F0001640 name: 11-cis retinal binding namespace: molecular_function def: "Interacting selectively with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [http://cancerweb.ncl.ac.uk/] synonym: "11-cis retinaldehyde binding" EXACT [] synonym: "vitamin A binding" BROAD [] xref: GO:0005502 is_a: CCO:F0003468 ! retinal binding [Term] id: CCO:F0001641 name: all-trans retinal binding namespace: molecular_function def: "Interacting selectively with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [http://cancerweb.ncl.ac.uk/] synonym: "all-trans retinaldehyde binding" EXACT [] synonym: "trans retinal binding" EXACT [] synonym: "visual yellow binding" EXACT [] synonym: "vitamin A binding" BROAD [] synonym: "xanthopsin" RELATED [] xref: GO:0005503 is_a: CCO:F0003468 ! retinal binding [Term] id: CCO:F0001642 name: fatty acid binding namespace: molecular_function def: "Interacting selectively with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005504 is_a: CCO:F0001816 ! lipid binding [Term] id: CCO:F0001643 name: iron ion binding namespace: molecular_function def: "Interacting selectively with iron (Fe) ions." [GOC:ai] subset: gosubset_prok synonym: "iron binding" EXACT [] xref: GO:0005506 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0001644 name: copper ion binding namespace: molecular_function def: "Interacting selectively with copper (Cu) ions." [GOC:ai] subset: gosubset_prok synonym: "copper binding" EXACT [] synonym: "copper/cadmium binding" BROAD [] xref: GO:0005507 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0001645 name: calcium ion binding namespace: molecular_function def: "Interacting selectively with calcium ions (Ca2+)." [GOC:ai] subset: goslim_generic subset: gosubset_prok synonym: "calcium ion storage activity" RELATED [] xref: GO:0005509 is_a: CCO:F0005808 ! cation binding is_a: CCO:F0006257 ! metal ion binding [Term] id: CCO:F0001646 name: protein binding namespace: molecular_function def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED [] synonym: "protein amino acid binding" EXACT [] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein tagging activity" RELATED [] xref: GO:0005515 xref: GO:0045308 xref: Reactome:6125 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0001647 name: calmodulin binding namespace: molecular_function def: "Interacting selectively with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] subset: gosubset_prok xref: GO:0005516 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001648 name: calmodulin inhibitor activity namespace: molecular_function xref: GO:0005517 is_a: CCO:F0001647 ! calmodulin binding [Term] id: CCO:F0001649 name: collagen binding namespace: molecular_function def: "Interacting selectively with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005518 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001650 name: cytoskeletal regulatory protein binding namespace: molecular_function def: "Interacting selectively with any protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540] xref: GO:0005519 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0001651 name: insulin-like growth factor binding namespace: molecular_function def: "Interacting selectively with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "IGF binding" EXACT [] xref: GO:0005520 is_a: CCO:F0004188 ! growth factor binding [Term] id: CCO:F0001652 name: lamin binding namespace: molecular_function def: "Interacting selectively with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "lamin/chromatin binding" BROAD [] xref: GO:0005521 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001653 name: profilin binding namespace: molecular_function def: "Interacting selectively with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: GO:0005522 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001654 name: tropomyosin binding namespace: molecular_function def: "Interacting selectively with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [http://cancerweb.ncl.ac.uk/] xref: GO:0005523 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0001655 name: ATP binding namespace: molecular_function def: "Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005524 is_a: CCO:F0005022 ! adenyl ribonucleotide binding [Term] id: CCO:F0001656 name: GTP binding namespace: molecular_function def: "Interacting selectively with GTP, guanosine triphosphate." [GOC:ai] subset: gosubset_prok xref: GO:0005525 is_a: CCO:F0005024 ! guanyl ribonucleotide binding [Term] id: CCO:F0001657 name: macrolide binding namespace: molecular_function def: "Interacting selectively with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005527 is_a: CCO:F0001746 ! drug binding [Term] id: CCO:F0001658 name: FK506 binding namespace: molecular_function def: "Interacting selectively with the immunosuppressant FK506." [GOC:jl] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED [] xref: GO:0005528 is_a: CCO:F0001657 ! macrolide binding [Term] id: CCO:F0001659 name: sugar binding namespace: molecular_function def: "Interacting selectively with any mono-, di- or trisaccharide carbohydrate." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005529 is_a: CCO:F0004356 ! carbohydrate binding [Term] id: CCO:F0001660 name: galactose binding namespace: molecular_function def: "Interacting selectively with galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactose binding lectin" RELATED [] xref: GO:0005534 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0001661 name: glucose binding namespace: molecular_function def: "Interacting selectively with the D- and L-enantiomers of glucose." [GOC:jl] subset: gosubset_prok xref: GO:0005536 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0001662 name: mannose binding namespace: molecular_function def: "Interacting selectively with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [GOC:jl, ISBN:0192800981] subset: gosubset_prok synonym: "mannose binding lectin" RELATED [] xref: GO:0005537 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0001663 name: glycosaminoglycan binding namespace: molecular_function def: "Interacting selectively with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005539 is_a: CCO:F0004357 ! polysaccharide binding [Term] id: CCO:F0001664 name: hyaluronic acid binding namespace: molecular_function def: "Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "hyaluronan binding" EXACT [] xref: GO:0005540 is_a: CCO:F0001663 ! glycosaminoglycan binding [Term] id: CCO:F0001665 name: folic acid binding namespace: molecular_function def: "Interacting selectively with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "folate binding" EXACT [] synonym: "vitamin B9 binding" EXACT [] synonym: "vitamin M binding" EXACT [] xref: GO:0005542 is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0001666 name: phospholipid binding namespace: molecular_function def: "Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005543 is_a: CCO:F0001816 ! lipid binding [Term] id: CCO:F0001667 name: calcium-dependent phospholipid binding namespace: molecular_function def: "Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] subset: gosubset_prok xref: GO:0005544 is_a: CCO:F0001666 ! phospholipid binding [Term] id: CCO:F0001668 name: phosphatidylinositol binding namespace: molecular_function def: "Interacting selectively with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0005545 is_a: CCO:F0005562 ! phosphoinositide binding [Term] id: CCO:F0001669 name: phosphatidylinositol-4,5-bisphosphate binding namespace: molecular_function def: "Interacting selectively with phosphatidylinositol-4,5-bisphosphate, a diphosphorylated derivative of phosphatidylinositol." [GOC:bf, GOC:jl] xref: GO:0005546 is_a: CCO:F0005562 ! phosphoinositide binding [Term] id: CCO:F0001670 name: phosphatidylinositol-3,4,5-triphosphate binding namespace: molecular_function def: "Interacting selectively with phosphatidylinositol-3,4,5-triphosphate, the triphosphorylated derivative of phosphatidylinositol." [GOC:bf, GOC:jl] xref: GO:0005547 is_a: CCO:F0005562 ! phosphoinositide binding [Term] id: CCO:F0001671 name: phospholipid transporter activity namespace: molecular_function def: "Enables the directed movement of phospholipids into, out of, within or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0005548 xref: GO:0008497 is_a: CCO:F0001556 ! lipid transporter activity [Term] id: CCO:F0001672 name: odorant binding namespace: molecular_function def: "Interacting selectively with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: goslim_pir subset: gosubset_prok xref: GO:0005549 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0001673 name: pheromone binding namespace: molecular_function def: "Interacting selectively with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] xref: GO:0005550 is_a: CCO:F0001672 ! odorant binding [Term] id: CCO:F0001674 name: chemokine activity namespace: molecular_function def: "The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation." [http://www.copewithcytokines.de/cope.cgi?001252] comment: See also the molecular function term 'cytokine activity ; GO:0005125'. xref: GO:0008009 is_a: CCO:F0001427 ! cytokine activity is_a: CCO:F0005665 ! chemokine receptor binding [Term] id: CCO:F0001675 name: structural constituent of chitin-based larval cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of larval cuticle (sensu Insecta)" EXACT [] xref: GO:0008010 is_a: CCO:F0001490 ! structural constituent of chitin-based cuticle [Term] id: CCO:F0001676 name: structural constituent of pupal chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an pupa." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of pupal cuticle (sensu Insecta)" EXACT [] xref: GO:0008011 is_a: CCO:F0001490 ! structural constituent of chitin-based cuticle [Term] id: CCO:F0001677 name: structural constituent of adult chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of adult cuticle (sensu Insecta)" EXACT [] xref: GO:0008012 is_a: CCO:F0001490 ! structural constituent of chitin-based cuticle [Term] id: CCO:F0001678 name: beta-catenin binding namespace: molecular_function def: "Interacting selectively with the beta subunit of the catenin complex." [GOC:bf] xref: GO:0008013 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001679 name: microtubule binding namespace: molecular_function def: "Interacting selectively with microtubules, filaments composed of tubulin monomers." [GOC:krc] synonym: "microtubule severing activity" RELATED [] synonym: "microtubule/chromatin interaction" RELATED [] xref: GO:0008017 is_a: CCO:F0002987 ! tubulin binding [Term] id: CCO:F0001680 name: G-protein coupled photoreceptor activity namespace: molecular_function def: "A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light." [GOC:dph, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "G protein coupled photoreceptor activity" EXACT [] synonym: "G-protein-coupled photoreceptor activity" EXACT [] xref: GO:0004975 xref: GO:0008020 is_a: CCO:F0000141 ! rhodopsin-like receptor activity is_a: CCO:F0002410 ! photoreceptor activity [Term] id: CCO:F0001681 name: protein C-terminus binding namespace: molecular_function def: "Interacting selectively with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "C-terminal binding" EXACT [] xref: GO:0008022 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001682 name: ATP-dependent helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok xref: GO:0008026 is_a: CCO:F0000803 ! helicase activity is_a: CCO:F0005696 ! ATPase activity, coupled [Term] id: CCO:F0001683 name: monocarboxylic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] subset: gosubset_prok synonym: "monocarboxylate carrier" NARROW [] synonym: "prostaglandin/thromboxane transporter activity" NARROW [] xref: GO:0008028 xref: GO:0008505 is_a: CCO:F0006282 ! carboxylic acid transmembrane transporter activity [Term] id: CCO:F0001684 name: pentraxin receptor activity namespace: molecular_function def: "Combining with a pentraxin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). synonym: "pentaxin receptor" EXACT [] xref: GO:0008029 is_a: CCO:F0000221 ! opsonin receptor activity is_a: CCO:F0000238 ! pentraxin binding [Term] id: CCO:F0001685 name: neuronal pentraxin receptor activity namespace: molecular_function synonym: "neuronal pentaxin receptor" EXACT [] xref: GO:0008030 is_a: CCO:F0001684 ! pentraxin receptor activity [Term] id: CCO:F0001686 name: eclosion hormone activity namespace: molecular_function xref: GO:0008031 is_a: CCO:F0001481 ! neuropeptide hormone activity [Term] id: CCO:F0001687 name: lipoprotein binding namespace: molecular_function def: "Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0008034 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001688 name: high-density lipoprotein binding namespace: molecular_function def: "Interacting selectively with high-density lipoprotein: one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0008035 is_a: CCO:F0001687 ! lipoprotein binding [Term] id: CCO:F0001689 name: diuretic hormone receptor activity namespace: molecular_function def: "Combining with a diuretic hormone to initiate a change in cell activity." [GOC:ai] xref: GO:0008036 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0001690 name: axon guidance receptor activity namespace: molecular_function xref: GO:0008046 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001691 name: enzyme activator activity namespace: molecular_function def: "Increases the activity of an enzyme." [GOC:mah] subset: gosubset_prok xref: GO:0008047 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0001692 name: calcium sensitive guanylate cyclase activator activity namespace: molecular_function xref: GO:0008048 is_a: CCO:F0004360 ! guanylate cyclase activator activity [Term] id: CCO:F0001693 name: ARF GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah] xref: GO:0008060 is_a: CCO:F0001388 ! small GTPase regulator activity is_a: CCO:F0001401 ! GTPase activator activity [Term] id: CCO:F0001694 name: chitin binding namespace: molecular_function def: "Interacting selectively with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0008061 is_a: CCO:F0004357 ! polysaccharide binding [Term] id: CCO:F0001695 name: glutamate receptor activity namespace: molecular_function def: "Combining with glutamate to initiate a change in cell activity." [GOC:ai] subset: gosubset_prok xref: GO:0008066 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001696 name: metabotropic glutamate, GABA-B-like receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:tb, IUPHAR:2.3] synonym: "class C G protein coupled receptor" BROAD [] synonym: "class C G-protein coupled receptor" BROAD [] synonym: "class C GPCR" BROAD [] synonym: "class C orphan receptor activity" EXACT [] xref: GO:0001643 xref: GO:0001645 xref: GO:0008067 is_a: CCO:F0001272 ! G-protein coupled receptor activity is_a: CCO:F0001695 ! glutamate receptor activity [Term] id: CCO:F0001697 name: extracellular-glutamate-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. xref: GO:0008068 is_a: CCO:F0001508 ! extracellular-glutamate-gated ion channel activity is_a: CCO:F0001522 ! chloride channel activity [Term] id: CCO:F0001698 name: ornithine decarboxylase inhibitor activity namespace: molecular_function def: "The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl] xref: GO:0008073 is_a: CCO:F0001213 ! enzyme inhibitor activity is_a: CCO:F0005777 ! ornithine decarboxylase regulator activity [Term] id: CCO:F0001699 name: translation termination factor activity namespace: molecular_function def: "Functions in the termination of translation." [GOC:ma] subset: gosubset_prok xref: GO:0008079 is_a: CCO:F0001739 ! translation factor activity, nucleic acid binding [Term] id: CCO:F0001700 name: N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0008080 is_a: CCO:F0003130 ! acetyltransferase activity is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0001701 name: phosphoric diester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "endonuclease VIII activity" RELATED [] synonym: "phosphodiesterase" NARROW [] xref: EC:3.1.4 xref: GO:0008081 xref: GO:0016792 is_a: CCO:F0005685 ! phosphoric ester hydrolase activity [Term] id: CCO:F0001702 name: growth factor activity namespace: molecular_function def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] xref: GO:0008083 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0001703 name: imaginal disc growth factor activity namespace: molecular_function xref: GO:0008084 is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0001704 name: light-activated voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light." [GOC:mtg_transport] synonym: "light-activated voltage gated calcium channel activity" EXACT [] synonym: "light-activated voltage-dependent calcium channel activity" EXACT [] xref: GO:0008086 is_a: CCO:F0001513 ! voltage-gated calcium channel activity is_a: CCO:F0002501 ! light-activated channel activity [Term] id: CCO:F0001705 name: cytoskeletal protein binding namespace: molecular_function def: "Interacting selectively with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: goslim_generic subset: gosubset_prok xref: GO:0008092 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001706 name: cytoskeletal adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a cytoskeletal molecule and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT] xref: GO:0008093 is_a: CCO:F0001705 ! cytoskeletal protein binding is_a: CCO:F0008241 ! molecular adaptor activity [Term] id: CCO:F0001707 name: DNA-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] synonym: "DNA dependent ATPase activity" EXACT [] synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] xref: GO:0004011 xref: GO:0008094 is_a: CCO:F0005696 ! ATPase activity, coupled [Term] id: CCO:F0001708 name: inositol-1,4,5-triphosphate receptor activity namespace: molecular_function def: "Combining with inositol-1,4,5-triphosphate to initiate a change in cell activity." [GOC:ai] synonym: "IP3 receptor activity" EXACT [] xref: GO:0008095 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0001709 name: juvenile hormone epoxide hydrolase activity namespace: molecular_function xref: EC:3.3.2.- xref: GO:0008096 is_a: CCO:F0000723 ! epoxide hydrolase activity [Term] id: CCO:F0001710 name: 5S rRNA binding namespace: molecular_function def: "Interacting selectively with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382] subset: gosubset_prok xref: GO:0008097 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0001711 name: 5S rRNA primary transcript binding namespace: molecular_function def: "Interacting selectively with the unprocessed 5S ribosomal RNA transcript." [GOC:jl] xref: GO:0008098 is_a: CCO:F0001710 ! 5S rRNA binding [Term] id: CCO:F0001712 name: alcohol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] subset: gosubset_prok synonym: "aldehyde reductase (NADPH) activity" EXACT [EC:1.1.1.2] synonym: "aldehyde reductase (NADPH2)" EXACT [] synonym: "NADP-aldehyde reductase activity" EXACT [] xref: EC:1.1.1.2 xref: GO:0008106 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0000511 ! aldo-keto reductase activity [Term] id: CCO:F0001713 name: galactoside 2-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69] subset: gosubset_prok synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT [] synonym: "alpha-(1->2)-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-L-fucose:lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] xref: EC:2.4.1.69 xref: GO:0008107 xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN is_a: CCO:F0004632 ! alpha(1,2)-fucosyltransferase activity [Term] id: CCO:F0001714 name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose." [EC:2.7.7.12] subset: gosubset_prok synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "hexose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.12] synonym: "hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12] synonym: "uridyltransferase activity" EXACT [EC:2.7.7.12] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12] xref: EC:2.7.7.12 xref: GO:0008108 xref: MetaCyc:GALACTURIDYLYLTRANS-RXN xref: Reactome:22869 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0001715 name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150] synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150] xref: EC:2.4.1.150 xref: GO:0008109 xref: MetaCyc:2.4.1.150-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0001716 name: histidine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine + 2-oxoglutarate = imidazol-5-yl-pyruvate + L-glutamate." [EC:2.6.1.38] synonym: "histidine aminotransferase activity" EXACT [] synonym: "histidine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38] synonym: "L-histidine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38] xref: EC:2.6.1.38 xref: GO:0008110 xref: MetaCyc:HISTTRANSAM-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0001717 name: alpha-methylacyl-CoA racemase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4] subset: gosubset_prok synonym: "2-methylacyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.4] xref: EC:5.1.99.4 xref: GO:0008111 xref: MetaCyc:5.1.99.4-RXN is_a: CCO:F0003417 ! racemase and epimerase activity [Term] id: CCO:F0001718 name: nicotinamide N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide." [EC:2.1.1.1] subset: gosubset_prok synonym: "nicotinamide methyltransferase activity" EXACT [EC:2.1.1.1] synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT [EC:2.1.1.1] xref: EC:2.1.1.1 xref: GO:0008112 xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN xref: Reactome:22892 is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0001719 name: peptide-methionine-(S)-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.11, PMID:11169920] subset: gosubset_prok synonym: "methionine S-oxide reductase (S-form oxidizing) activity" EXACT [EC:1.8.4.11] synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulfoxide (protein) reductase activity" EXACT [] synonym: "methionine sulfoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulphoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "MsrA" RELATED [EC:1.8.4.11] synonym: "peptide Met(O) reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide methionine sulfoxide reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" EXACT [EC:1.8.4.11] synonym: "protein-methionine-S-oxide reductase activity" EXACT [EC:1.8.4.11] xref: EC:1.8.4.11 xref: GO:0008113 xref: GO:0033742 xref: MetaCyc:PROTEIN-METHIONINE-S-OXIDE-REDUCTASE-RXN is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0001720 name: phosphogluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43] synonym: "2-keto-6-phosphogluconate reductase activity" EXACT [EC:1.1.1.43] synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT [] synonym: "6-phosphogluconate dehydrogenase (NAD)" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43] synonym: "gluconate 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.43] synonym: "phosphogluconate dehydrogenase activity" EXACT [EC:1.1.1.43] xref: EC:1.1.1.43 xref: GO:0008114 xref: MetaCyc:1.1.1.43-RXN xref: Reactome:22895 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001721 name: sarcosine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: sarcosine + H2O + O2 = glycine + formaldehyde + H2O2." [EC:1.5.3.1] subset: gosubset_prok synonym: "sarcosine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.1] xref: EC:1.5.3.1 xref: GO:0008115 xref: MetaCyc:SARCOX-RXN is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0001722 name: prostaglandin-I synthase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate." [EC:5.3.99.4] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" EXACT [EC:5.3.99.4] synonym: "cytochrome P450 CYP8A1" NARROW [] synonym: "PGI(2) synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI(2) synthetase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostacyclin synthase activity" EXACT [EC:5.3.99.4] synonym: "prostacycline synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostagladin I2 synthetase activity" EXACT [EC:5.3.99.4] xref: EC:5.3.99.4 xref: GO:0008116 xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN xref: Reactome:22900 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0001723 name: sphinganine-1-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27] subset: gosubset_prok synonym: "dihydrosphingosine 1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate alkanal-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] xref: EC:4.1.2.27 xref: GO:0008117 xref: GO:0016001 xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0001724 name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein." [EC:2.4.99.6] synonym: "alpha2->3 sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.6] synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "SiaT" RELATED [EC:2.4.99.6] xref: EC:2.4.99.6 xref: GO:0008118 xref: MetaCyc:2.4.99.6-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0001725 name: thiopurine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67] subset: gosubset_prok synonym: "6-thiopurine transmethylase activity" EXACT [EC:2.1.1.67] synonym: "mercaptopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "thiopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "TPMT" RELATED [EC:2.1.1.67] xref: EC:2.1.1.67 xref: GO:0008119 xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN xref: Reactome:22905 is_a: CCO:F0001759 ! S-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0001726 name: ceramide glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80] subset: gosubset_prok synonym: "ceramide:UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "ceramide:UDPGlc glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "glucosylceramide synthase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] xref: EC:2.4.1.80 xref: GO:0008120 xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0001727 name: ubiquinol-cytochrome-c reductase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c." [EC:1.10.2.2, ISBN:0198547684] subset: gosubset_prok synonym: "coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "coenzyme QH2-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:1.10.2.2] synonym: "CoQH2-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "cytochrome bc1 complex" RELATED [] synonym: "dihydrocoenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "mitochondrial electron transport complex III" RELATED [EC:1.10.2.2] synonym: "QH2:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport)" RELATED [EC:1.10.2.2] synonym: "ubihydroquinol:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c2 reductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone--cytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome b-c1 oxidoreductase activity" EXACT [] synonym: "ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome c reductase activity" EXACT [EC:1.10.2.2] xref: EC:1.10.2.2 xref: GO:0008121 xref: MetaCyc:1.10.2.2-RXN is_a: CCO:F0002559 ! hydrogen ion transmembrane transporter activity is_a: CCO:F0003272 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor [Term] id: CCO:F0001728 name: cholesterol 7-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.17] synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT [] synonym: "cholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.17] synonym: "cholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.17] synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.17] synonym: "cytochrome P450 CYP7A1" NARROW [] xref: EC:1.14.13.17 xref: GO:0008123 xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0001729 name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4-alpha-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O." [EC:4.2.1.96] subset: gosubset_prok synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96] synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT [] synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" EXACT [EC:4.2.1.96] synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4alpha-carbinolamine dehydratase activity" EXACT [EC:4.2.1.96] synonym: "tetrahydrobiopterin dehydratase activity" EXACT [EC:4.2.1.96] xref: EC:4.2.1.96 xref: GO:0008124 xref: MetaCyc:4.2.1.96-RXN xref: Reactome:22934 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0001730 name: pancreatic elastase I activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [EC:3.4.21.36] synonym: "elaszym" RELATED [EC:3.4.21.36] synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36] synonym: "serine elastase" BROAD [EC:3.4.21.36] xref: EC:3.4.21.36 xref: GO:0008125 xref: MetaCyc:3.4.21.36-RXN is_a: CCO:F0001736 ! pancreatic elastase activity [Term] id: CCO:F0001731 name: acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6] subset: gosubset_prok synonym: "acetic ester hydrolase activity" EXACT [EC:3.1.1.6] synonym: "acetic-ester acetylhydrolase activity" EXACT [EC:3.1.1.6] synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6] synonym: "chloroesterase" NARROW [EC:3.1.1.6] synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6] synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6] xref: EC:3.1.1.6 xref: GO:0008126 xref: MetaCyc:ACETYLESTERASE-RXN xref: UM-BBD_enzymeID:e0052 is_a: CCO:F0008362 ! short-chain carboxylesterase activity [Term] id: CCO:F0001732 name: quercetin 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin + O2 = 2-protocatechuoylphloroglucinolcarboxylate + CO." [EC:1.13.11.24] synonym: "flavonol 2,4-oxygenase activity" EXACT [EC:1.13.11.24] synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.24] synonym: "quercetinase activity" EXACT [EC:1.13.11.24] xref: EC:1.13.11.24 xref: GO:0008127 xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0001733 name: actinidain activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14] synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14] synonym: "actinidin activity" EXACT [EC:3.4.22.14] synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14] xref: EC:3.4.22.14 xref: GO:0008129 xref: MetaCyc:3.4.22.14-RXN is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0001734 name: neutrophil collagenase activity namespace: molecular_function def: "Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [EC:3.4.24.34] synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34] synonym: "MMP-8" EXACT [] synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34] xref: EC:3.4.24.34 xref: GO:0008130 xref: MetaCyc:3.4.24.34-RXN is_a: CCO:F0001737 ! collagenase activity [Term] id: CCO:F0001735 name: amine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2." [EC:1.4.3.4, EC:1.4.3.6] subset: gosubset_prok synonym: "adrenalin oxidase" NARROW [EC:1.4.3.4] synonym: "adrenaline oxidase activity" NARROW [EC:1.4.3.4] synonym: "amine oxidase (copper-containing) activity" NARROW [] synonym: "amine oxidase (flavin-containing) activity" NARROW [] synonym: "amine oxidase (pyridoxal containing)" NARROW [EC:1.4.3.4] synonym: "amine oxygen oxidoreductase activity" EXACT [EC:1.4.3.4] synonym: "amine:oxygen oxidoreductase (deaminating) (copper-containing)" NARROW [EC:1.4.3.6] synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing)" NARROW [EC:1.4.3.4] synonym: "benzylamine oxidase" NARROW [EC:1.4.3.4] synonym: "Cu-amine oxidase activity" NARROW [EC:1.4.3.6] synonym: "DAO activity" NARROW [EC:1.4.3.4] synonym: "diamine oxidase activity" NARROW [EC:1.4.3.6] synonym: "diamine:O2 oxidoreductase (deaminating)" NARROW [EC:1.4.3.6] synonym: "diamino oxhydrase activity" NARROW [EC:1.4.3.4] synonym: "epinephrine oxidase" NARROW [EC:1.4.3.4] synonym: "histaminase activity" NARROW [EC:1.4.3.6] synonym: "histamine deaminase" NARROW [EC:1.4.3.6] synonym: "histamine oxidase" NARROW [EC:1.4.3.6] synonym: "MAO" RELATED [EC:1.4.3.4] synonym: "monoamine oxidase activity" NARROW [EC:1.4.3.4] synonym: "monoamine:O2 oxidoreductase (deaminating)" NARROW [EC:1.4.3.4] synonym: "semicarbazide-sensitive amine oxidase" NARROW [EC:1.4.3.6] synonym: "serotonin deaminase" NARROW [EC:1.4.3.4] synonym: "spermidine oxidase" NARROW [EC:1.4.3.4] synonym: "spermine oxidase" NARROW [EC:1.4.3.4] synonym: "SSAO" RELATED [EC:1.4.3.4] synonym: "tyraminase activity" NARROW [EC:1.4.3.4] synonym: "tyramine oxidase activity" NARROW [EC:1.4.3.4] xref: EC:1.4.3.4 xref: EC:1.4.3.6 xref: GO:0004041 xref: GO:0008122 xref: GO:0008131 xref: MetaCyc:AMINE-OXIDASE-(FLAVIN-CONTAINING)-RXN xref: MetaCyc:AMINEOXID-RXN xref: Reactome:7141 is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0001736 name: pancreatic elastase activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71] xref: EC:3.4.21.- xref: GO:0008132 is_a: CCO:F0000698 ! serine-type endopeptidase activity is_a: CCO:F0005704 ! elastase activity [Term] id: CCO:F0001737 name: collagenase activity namespace: molecular_function xref: EC:3.4.24.- xref: GO:0008133 is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0001738 name: transcription factor binding namespace: molecular_function def: "Interacting selectively with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TF binding" EXACT [] xref: GO:0008134 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001739 name: translation factor activity, nucleic acid binding namespace: molecular_function def: "Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome." [GOC:ai] subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: GO:0008135 is_a: CCO:F0000273 ! nucleic acid binding is_a: CCO:F0006094 ! translation regulator activity [Term] id: CCO:F0001740 name: NADH dehydrogenase (ubiquinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] subset: gosubset_prok synonym: "coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "complex 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "complex I (electron transport chain) activity" RELATED [EC:1.6.5.3] synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:1.6.5.3] synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:1.6.5.3] synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "electron transfer complex I activity" RELATED [EC:1.6.5.3] synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:1.6.5.3] synonym: "mitochondrial electron transport complex I activity" NARROW [EC:1.6.5.3] synonym: "NADH coenzyme Q1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-Q6 oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone-1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:1.6.5.3] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "ubiquinone reductase activity" EXACT [] xref: EC:1.6.5.3 xref: GO:0008137 xref: MetaCyc:NADH-DEHYDROG-RXN xref: Reactome:22973 is_a: CCO:F0007489 ! NADH dehydrogenase (quinone) activity [Term] id: CCO:F0001741 name: protein tyrosine/serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate." [GOC:mah] subset: gosubset_prok synonym: "dual-specificity protein phosphatase" BROAD [] xref: EC:3.1.3.- xref: GO:0008138 is_a: CCO:F0001086 ! phosphoprotein phosphatase activity [Term] id: CCO:F0001742 name: nuclear localization sequence binding namespace: molecular_function def: "Interacting selectively with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai] synonym: "NLS binding" EXACT [] synonym: "nuclear localization signal binding" EXACT [] xref: GO:0008139 is_a: CCO:F0001368 ! signal sequence binding [Term] id: CCO:F0001743 name: cAMP response element binding protein binding namespace: molecular_function synonym: "3',5' cAMP response element binding protein binding" EXACT [] synonym: "3',5'-cAMP response element binding protein binding" EXACT [] synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT [] synonym: "cyclic AMP response element binding protein binding" EXACT [] xref: GO:0008140 is_a: CCO:F0000300 ! transcription coactivator activity [Term] id: CCO:F0001744 name: oxysterol binding namespace: molecular_function def: "Interacting selectively with oxysterol, an oxidized form of cholesterol." [http://www.onelook.com/] xref: GO:0008142 is_a: CCO:F0005049 ! sterol binding [Term] id: CCO:F0001745 name: poly(A) binding namespace: molecular_function def: "Interacting selectively with the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "poly-A binding" EXACT [] synonym: "polyadenylate binding" EXACT [] xref: GO:0008143 is_a: CCO:F0000312 ! single-stranded RNA binding is_a: CCO:F0000313 ! mRNA binding [Term] id: CCO:F0001746 name: drug binding namespace: molecular_function def: "Interacting selectively with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok xref: GO:0008144 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0001747 name: phenylalkylamine binding namespace: molecular_function def: "Interacting selectively with phenylalkylamine or any of its derivatives." [GOC:jl] xref: GO:0008145 is_a: CCO:F0001746 ! drug binding [Term] id: CCO:F0001748 name: sulfotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "sulphotransferase activity" EXACT [] xref: EC:2.8.2 xref: GO:0008146 xref: Reactome:2397 is_a: CCO:F0003354 ! transferase activity, transferring sulfur-containing groups [Term] id: CCO:F0001749 name: structural constituent of bone namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah] xref: GO:0008147 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0001750 name: negative transcription elongation factor activity namespace: molecular_function def: "Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] xref: GO:0008148 is_a: CCO:F0000298 ! transcription elongation regulator activity [Term] id: CCO:F0001751 name: protein phosphatase 1 binding namespace: molecular_function def: "Interacting selectively with the enzyme protein phosphatase 1." [GOC:jl] xref: GO:0008157 is_a: CCO:F0004212 ! protein phosphatase binding [Term] id: CCO:F0001752 name: hedgehog receptor activity namespace: molecular_function def: "Combining with the hedgehog protein to initiate a change in cell activity." [GOC:go_curators] synonym: "patched activity" EXACT [] xref: GO:0008158 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001753 name: positive transcription elongation factor activity namespace: molecular_function def: "Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] xref: GO:0008159 is_a: CCO:F0000298 ! transcription elongation regulator activity [Term] id: CCO:F0001754 name: protein tyrosine phosphatase activator activity namespace: molecular_function def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0008160 is_a: CCO:F0004134 ! phosphatase activator activity [Term] id: CCO:F0001755 name: methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methylase" BROAD [] xref: EC:2.1.1 xref: GO:0004480 xref: GO:0008168 xref: Reactome:1062 is_a: CCO:F0003317 ! transferase activity, transferring one-carbon groups [Term] id: CCO:F0001756 name: C-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008169 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0001757 name: N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008170 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0001758 name: O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008171 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0001759 name: S-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008172 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0001760 name: RNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008173 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0001761 name: mRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008174 is_a: CCO:F0001760 ! RNA methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0001762 name: tRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008175 is_a: CCO:F0001760 ! RNA methyltransferase activity [Term] id: CCO:F0001763 name: tRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33] subset: gosubset_prok synonym: "7-methylguanine transfer ribonucleate methylase activity" EXACT [EC:2.1.1.33] synonym: "N7-methylguanine methylase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "transfer ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] xref: EC:2.1.1.33 xref: GO:0008176 xref: MetaCyc:TRNA-(GUANINE-N7-)-METHYLTRANSFERASE-RXN is_a: CCO:F0003146 ! tRNA (guanine) methyltransferase activity [Term] id: CCO:F0001764 name: succinate dehydrogenase (ubiquinone) activity namespace: molecular_function def: "Catalysis of the reaction: succinate + quinone = fumarate + quinol." [EC:1.3.5.1] subset: gosubset_prok synonym: "complex II" RELATED [EC:1.3.5.1] synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1] synonym: "menaquinol: fumarate oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "quinol:fumarate oxidoreductase activity" EXACT [] synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1] synonym: "succinate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1] xref: EC:1.3.5.1 xref: GO:0008177 xref: GO:0019737 xref: Reactome:23070 is_a: CCO:F0003236 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: CCO:F0001765 name: adenylate cyclase binding namespace: molecular_function def: "Interacting selectively with the enzyme adenylate cyclase." [GOC:jl] synonym: "adenylyl cyclase binding" EXACT [] xref: GO:0008179 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0001766 name: glycogen phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN] subset: gosubset_prok xref: GO:0008184 xref: MetaCyc:GLYCOPHOSPHORYL-RXN xref: Reactome:23099 is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0001767 name: RNA-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of RNA; drives another reaction." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT [] xref: GO:0004010 xref: GO:0008186 is_a: CCO:F0005696 ! ATPase activity, coupled [Term] id: CCO:F0001768 name: poly-pyrimidine tract binding namespace: molecular_function def: "Interacting selectively with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl] xref: GO:0008187 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0001769 name: neuropeptide receptor activity namespace: molecular_function def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] xref: GO:0008188 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled is_a: CCO:F0004488 ! neurotransmitter receptor activity is_a: CCO:F0005746 ! neuropeptide binding [Term] id: CCO:F0001770 name: eukaryotic initiation factor 4E binding namespace: molecular_function def: "Interacting selectively with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "eIF4E binding" EXACT [] xref: GO:0008190 is_a: CCO:F0004653 ! translation initiation factor binding [Term] id: CCO:F0001771 name: metalloendopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai] subset: gosubset_prok synonym: "metalloprotease inhibitor" BROAD [] synonym: "metalloproteinase inhibitor" BROAD [] xref: GO:0008191 is_a: CCO:F0001222 ! endopeptidase inhibitor activity [Term] id: CCO:F0001772 name: RNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah] xref: EC:2.7.7.- xref: GO:0008192 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0001773 name: tRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461] xref: EC:2.7.7.- xref: GO:0008193 is_a: CCO:F0001772 ! RNA guanylyltransferase activity [Term] id: CCO:F0001774 name: UDP-glycosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783] subset: gosubset_prok xref: GO:0008194 xref: Reactome:23123 is_a: CCO:F0003332 ! transferase activity, transferring glycosyl groups [Term] id: CCO:F0001775 name: phosphatidate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4] synonym: "3-sn-phosphatidate phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "acid phosphatidyl phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "phosphatidate phosphohydrolase activity" EXACT [] synonym: "phosphatidic acid phosphatase activity" EXACT [EC:3.1.3.4] xref: EC:3.1.3.4 xref: GO:0004606 xref: GO:0008195 xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN xref: Reactome:23125 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0001776 name: vitellogenin receptor activity namespace: molecular_function def: "Combining with vitellogenin to initiate a change in cell activity." [GOC:ai] xref: GO:0008196 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0001777 name: ferrous iron binding namespace: molecular_function def: "Interacting selectively with ferrous iron, Fe(II)." [GOC:ai] subset: gosubset_prok xref: GO:0008198 is_a: CCO:F0001643 ! iron ion binding [Term] id: CCO:F0001778 name: ferric iron binding namespace: molecular_function def: "Interacting selectively with ferric iron, Fe(III)." [GOC:ai] subset: gosubset_prok xref: GO:0008199 is_a: CCO:F0001643 ! iron ion binding [Term] id: CCO:F0001779 name: ion channel inhibitor activity namespace: molecular_function subset: gosubset_prok xref: GO:0008200 is_a: CCO:F0003087 ! channel inhibitor activity [Term] id: CCO:F0001780 name: heparin binding namespace: molecular_function def: "Interacting selectively with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha1-4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0008201 is_a: CCO:F0001663 ! glycosaminoglycan binding [Term] id: CCO:F0001781 name: tyramine receptor activity namespace: molecular_function def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [http://www.onelook.com/] xref: GO:0008226 is_a: CCO:F0001782 ! amine receptor activity [Term] id: CCO:F0001782 name: amine receptor activity namespace: molecular_function def: "Combining with a biogenic amine to initiate a change in cell activity." [GOC:dph] subset: gosubset_prok synonym: "biogenic amine receptor" NARROW [] xref: GO:0008227 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0001783 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds." [GOC:jl] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] xref: EC:3.4 xref: GO:0008233 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0001784 name: cysteine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cysteine protease activity" EXACT [] synonym: "thiol protease activity" EXACT [] xref: EC:3.4.-.- xref: GO:0004220 xref: GO:0008234 is_a: CCO:F0001783 ! peptidase activity [Term] id: CCO:F0001785 name: metalloexopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0008235 is_a: CCO:F0001787 ! metallopeptidase activity is_a: CCO:F0001788 ! exopeptidase activity [Term] id: CCO:F0001786 name: serine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://en.wikipedia.org/wiki/Serine_hydrolase, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "serine protease activity" EXACT [] xref: GO:0008236 is_a: CCO:F0001783 ! peptidase activity is_a: CCO:F0003609 ! serine hydrolase activity [Term] id: CCO:F0001787 name: metallopeptidase activity namespace: molecular_function subset: gosubset_prok xref: GO:0008237 xref: Reactome:1795 is_a: CCO:F0001783 ! peptidase activity [Term] id: CCO:F0001788 name: exopeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "exoprotease activity" EXACT [] xref: GO:0008238 is_a: CCO:F0001783 ! peptidase activity [Term] id: CCO:F0001789 name: dipeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] subset: gosubset_prok xref: GO:0008239 is_a: CCO:F0003376 ! dipeptidyl-peptidase and tripeptidyl-peptidase activity [Term] id: CCO:F0001790 name: tripeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah] xref: EC:3.4.14.- xref: GO:0008240 is_a: CCO:F0001786 ! serine-type peptidase activity is_a: CCO:F0003376 ! dipeptidyl-peptidase and tripeptidyl-peptidase activity [Term] id: CCO:F0001791 name: peptidyl-dipeptidase activity namespace: molecular_function def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] subset: gosubset_prok xref: EC:3.4.15 xref: GO:0008241 is_a: CCO:F0001788 ! exopeptidase activity [Term] id: CCO:F0001792 name: omega peptidase activity namespace: molecular_function def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of a-carboxyl to a-amino groups)." [EC:3.4.19.-] subset: gosubset_prok xref: EC:3.4.19 xref: GO:0008242 is_a: CCO:F0001788 ! exopeptidase activity [Term] id: CCO:F0001793 name: plasminogen activator activity namespace: molecular_function def: "Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [EC:3.4.21.68, EC:3.4.21.73] subset: gosubset_prok synonym: "abbokinase activity" EXACT [EC:3.4.21.68] synonym: "cellular plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "double-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "plasminogen activator, tissue-type" RELATED [EC:3.4.21.68] synonym: "t-PA" RELATED [EC:3.4.21.68] synonym: "t-plasminogen activator activity" NARROW [] synonym: "tissue plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "tissue-type plasminogen activator activity" RELATED [EC:3.4.21.-] synonym: "tPA activity" NARROW [EC:3.4.21.-] synonym: "two-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "u-PA" RELATED [EC:3.4.21.68] synonym: "u-plasminogen activator activity" NARROW [] synonym: "uPA" RELATED [EC:3.4.21.68] synonym: "urinary esterase A" RELATED [EC:3.4.21.68] synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "urokinase activity" RELATED [EC:3.4.21.-] synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68] synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] xref: EC:3.4.21.- xref: EC:3.4.21.68 xref: EC:3.4.21.73 xref: GO:0004296 xref: GO:0004297 xref: GO:0008243 xref: MetaCyc:3.4.21.68-RXN xref: MetaCyc:3.4.21.73-RXN xref: Reactome:9757 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0001794 name: tRNA-specific adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] subset: gosubset_prok synonym: "tRNA-adenosine deaminase activity" EXACT [] xref: EC:3.5.4.- xref: GO:0008251 is_a: CCO:F0000485 ! adenosine deaminase activity [Term] id: CCO:F0001795 name: nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31] subset: gosubset_prok synonym: "acid nucleotidase activity" EXACT [EC:3.1.3.31] synonym: "deoxyinosine-activated nucleotidase (DIAN)" EXACT [EC:3.1.3.31] synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" EXACT [EC:3.1.3.31] synonym: "NSP I" RELATED [EC:3.1.3.31] synonym: "NSP II" RELATED [EC:3.1.3.31] synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31] synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31] xref: EC:3.1.3.31 xref: GO:0008252 xref: MetaCyc:NUCLEOTIDASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0001796 name: 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] subset: gosubset_prok synonym: "5' nucleotidase activity" EXACT [] synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5] synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5] synonym: "5'-AMPase" NARROW [EC:3.1.3.5] synonym: "5'-mononucleotidase activity" EXACT [EC:3.1.3.5] synonym: "5'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.5] synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5] synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5] synonym: "AMPase" NARROW [EC:3.1.3.5] synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5] synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5] synonym: "UMPase" NARROW [EC:3.1.3.5] synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5] xref: EC:3.1.3.5 xref: GO:0008253 xref: Reactome:23614 is_a: CCO:F0001795 ! nucleotidase activity [Term] id: CCO:F0001797 name: 3'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6] synonym: "3' nucleotidase activity" EXACT [] synonym: "3'-mononucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-phosphatase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6] xref: EC:3.1.3.6 xref: GO:0008254 xref: MetaCyc:3-NUCLEOTID-RXN is_a: CCO:F0001795 ! nucleotidase activity [Term] id: CCO:F0001798 name: ecdysis-triggering hormone activity namespace: molecular_function xref: GO:0008255 is_a: CCO:F0001481 ! neuropeptide hormone activity [Term] id: CCO:F0001799 name: protein histidine pros-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1] subset: gosubset_prok synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "HK2" RELATED [EC:2.7.13.1] synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1] xref: EC:2.7.13.1 xref: GO:0008256 xref: MetaCyc:PROTEIN-HISTIDINE-PROS-KINASE-RXN is_a: CCO:F0001044 ! protein histidine kinase activity [Term] id: CCO:F0001800 name: protein histidine tele-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2] synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "HK3" RELATED [EC:2.7.13.2] synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2] xref: EC:2.7.13.2 xref: GO:0008257 xref: MetaCyc:PROTEIN-HISTIDINE-TELE-KINASE-RXN is_a: CCO:F0001044 ! protein histidine kinase activity [Term] id: CCO:F0001801 name: 3-oxoacid CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5] subset: gosubset_prok synonym: "3-ketoacid CoA-transferase activity" EXACT [EC:2.8.3.5] synonym: "3-ketoacid coenzyme A transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxo-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid CoA dehydrogenase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetate succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" EXACT [EC:2.8.3.5] synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-ketoacid-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-oxo-acid CoA-transferase activity" EXACT [EC:2.8.3.5] xref: EC:2.8.3.5 xref: GO:0008260 xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN xref: Reactome:23643 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0001802 name: allatostatin receptor activity namespace: molecular_function def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai] xref: GO:0008261 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0001803 name: importin-alpha export receptor activity namespace: molecular_function def: "Interacting selectively with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm." [GOC:mah, GOC:vw, PMID:12486120] synonym: "importin-alpha binding" RELATED [] xref: GO:0008262 is_a: CCO:F0001369 ! nuclear export signal receptor activity is_a: CCO:F0001997 ! protein transporter activity [Term] id: CCO:F0001804 name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623] synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT [] xref: GO:0008263 is_a: CCO:F0000093 ! mismatch base pair DNA N-glycosylase activity [Term] id: CCO:F0001805 name: Mo-molybdopterin cofactor sulfurase activity namespace: molecular_function synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT [] synonym: "molybdopterin cofactor sulfurase activity" EXACT [] synonym: "molybdopterin synthase sulfurylase activity" EXACT [] xref: GO:0008265 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0001806 name: poly(U) binding namespace: molecular_function def: "Interacting selectively with a sequence of uracil residues in an RNA molecule." [GOC:mah] xref: GO:0008266 is_a: CCO:F0000312 ! single-stranded RNA binding [Term] id: CCO:F0001807 name: poly-glutamine tract binding namespace: molecular_function def: "Interacting selectively with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah] xref: GO:0008267 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0001808 name: receptor signaling protein tyrosine kinase signaling protein activity namespace: molecular_function synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT [] xref: GO:0008268 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0001809 name: JAK pathway signal transduction adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a molecule of the JAK signal transduction pathway and one or more other molecules of the pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT] xref: GO:0008269 is_a: CCO:F0001808 ! receptor signaling protein tyrosine kinase signaling protein activity is_a: CCO:F0008241 ! molecular adaptor activity [Term] id: CCO:F0001810 name: zinc ion binding namespace: molecular_function def: "Interacting selectively with zinc (Zn) ions." [GOC:ai] subset: gosubset_prok synonym: "zinc binding" EXACT [] xref: GO:0008270 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0001811 name: secondary active sulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] subset: gosubset_prok synonym: "secondary active sulphate transmembrane transporter activity" EXACT [] synonym: "sulfate porter activity" RELATED [] synonym: "sulphate porter activity" EXACT [] xref: GO:0008271 is_a: CCO:F0002594 ! sulfate transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0001812 name: calcium, potassium:sodium antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] synonym: "potassium-dependent sodium/calcium exchanger" RELATED [] xref: GO:0008273 is_a: CCO:F0002795 ! calcium:cation antiporter activity [Term] id: CCO:F0001813 name: protein methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008276 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0001814 name: sulfonylurea receptor activity namespace: molecular_function def: "Combining with sulfonylurea to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'. synonym: "sulphonylurea receptor activity" EXACT [] xref: GO:0008281 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0001815 name: boss receptor activity namespace: molecular_function def: "Combining with the protein bride of sevenless (boss) to initiate a change in cell activity." [GOC:jl] synonym: "sevenless receptor activity" RELATED [] xref: GO:0008288 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity [Term] id: CCO:F0001816 name: lipid binding namespace: molecular_function def: "Interacting selectively with a lipid." [GOC:ai] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0008289 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0001817 name: calcium- and calmodulin-responsive adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah] synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT [] synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT [] xref: GO:0008294 xref: Reactome:23748 is_a: CCO:F0000494 ! adenylate cyclase activity [Term] id: CCO:F0001818 name: 3'-5'-exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah] synonym: "3'-5' exodeoxyribonuclease activity" EXACT [] xref: GO:0008296 is_a: CCO:F0001875 ! 3'-5' exonuclease activity is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0001819 name: single-stranded DNA specific exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah] subset: gosubset_prok xref: GO:0008297 is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0001820 name: DNA bending activity namespace: molecular_function def: "The function of causing local conformational micropolymorphism of DNA in which the original B-DNA structure is only distorted but not extensively modified." [GOC:jl, PMID:10710711] subset: gosubset_prok xref: GO:0008301 is_a: CCO:F0000274 ! DNA binding [Term] id: CCO:F0001821 name: structural constituent of muscle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] xref: GO:0008307 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0001822 name: voltage-gated anion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage-dependent ion-selective channel activity" RELATED [] synonym: "voltage-gated ion-selective channel activity" RELATED [] xref: GO:0008308 xref: GO:0022844 is_a: CCO:F0001512 ! voltage-gated ion channel activity is_a: CCO:F0001521 ! anion channel activity [Term] id: CCO:F0001823 name: double-stranded DNA specific exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah] xref: GO:0008309 is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0001824 name: single-stranded DNA specific 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah] xref: GO:0008310 is_a: CCO:F0001818 ! 3'-5'-exodeoxyribonuclease activity is_a: CCO:F0001819 ! single-stranded DNA specific exodeoxyribonuclease activity [Term] id: CCO:F0001825 name: double-stranded DNA specific 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah] xref: GO:0008311 is_a: CCO:F0001818 ! 3'-5'-exodeoxyribonuclease activity is_a: CCO:F0001823 ! double-stranded DNA specific exodeoxyribonuclease activity [Term] id: CCO:F0001826 name: 7S RNA binding namespace: molecular_function def: "Interacting selectively with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, UniProtKB:P37108] subset: gosubset_prok xref: GO:0008312 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0001827 name: gurken receptor activity namespace: molecular_function def: "Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf] xref: GO:0008313 is_a: CCO:F0001343 ! epidermal growth factor receptor activity [Term] id: CCO:F0001828 name: structural constituent of vitelline membrane namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg." [GOC:mah, GOC:sensu] synonym: "structural constituent of vitelline membrane (sensu Insecta)" NARROW [] xref: GO:0008316 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0001829 name: gurken receptor binding namespace: molecular_function def: "Interacting selectively with the gurken growth factor receptor." [GOC:ai] synonym: "gurken receptor ligand" NARROW [] xref: GO:0008317 is_a: CCO:F0001456 ! epidermal growth factor receptor binding [Term] id: CCO:F0001830 name: protein prenyltransferase activity namespace: molecular_function def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah] xref: EC:2.5.1.- xref: GO:0008244 xref: GO:0008318 is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0001831 name: prenyl protein specific endopeptidase activity namespace: molecular_function xref: EC:3.4.24.- xref: GO:0008319 is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0001832 name: protein transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a protein from one side of a membrane to the other." [GOC:jl] subset: gosubset_prok xref: GO:0008320 is_a: CCO:F0001646 ! protein binding is_a: CCO:F0001997 ! protein transporter activity is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0001833 name: Ral guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: GO:0008321 is_a: CCO:F0001393 ! Ras guanyl-nucleotide exchange factor activity [Term] id: CCO:F0001834 name: Pro-X carboxypeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah] xref: GO:0008322 is_a: CCO:F0000649 ! carboxypeptidase activity [Term] id: CCO:F0001835 name: cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:df, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "transmembrane cation transporter activity" EXACT [] xref: GO:0008324 is_a: CCO:F0002557 ! ion transmembrane transporter activity [Term] id: CCO:F0001837 name: methyl-CpG binding namespace: molecular_function def: "Interacting selectively with a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232] xref: GO:0008327 is_a: CCO:F0000031 ! nucleotide binding is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0001838 name: pattern recognition receptor activity namespace: molecular_function def: "Combining with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. Such molecular patterns are sometimes associated with potential pathogens." [PMID:12507420, PMID:12925128, PMID:14523544] comment: Note that this term and its child terms are intended for gene products which are directly coupled to a signal transduction pathway; gene products which recognize polymeric structures such as polysaccharides or peptidoglycans in extracellular space, but are not directly coupled to signal transduction pathway, should use the term 'pattern binding ; GO:0001871' or its child terms. Note that many gene products that are called pattern recognition receptors in the literature have a broad range of potential ligands and also can be annotated to 'scavenger receptor activity ; GO:0005044'. synonym: "macrophage receptor activity" RELATED [] xref: GO:0008329 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0001839 name: protein tyrosine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein threonine/tyrosine phosphate + H2O = protein threonine/tyrosine + phosphate." [GOC:mah] xref: EC:3.1.3.- xref: GO:0008330 is_a: CCO:F0001086 ! phosphoprotein phosphatase activity [Term] id: CCO:F0001840 name: high voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] synonym: "high voltage gated calcium channel activity" EXACT [] synonym: "high voltage-dependent calcium channel activity" EXACT [] xref: GO:0008331 is_a: CCO:F0001513 ! voltage-gated calcium channel activity [Term] id: CCO:F0001841 name: low voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] synonym: "low voltage gated calcium channel activity" EXACT [] synonym: "low voltage-dependent calcium channel activity" EXACT [] synonym: "T-type channel" EXACT [] xref: GO:0008332 is_a: CCO:F0001513 ! voltage-gated calcium channel activity [Term] id: CCO:F0001842 name: gamma-butyrobetaine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2." [EC:1.14.11.1] subset: gosubset_prok synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.1] synonym: "alpha-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "g-butyrobetaine dioxygenase activity" EXACT [] synonym: "gamma-BBH activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT [] xref: EC:1.14.11.1 xref: GO:0008336 xref: MetaCyc:1.14.11.1-RXN xref: Reactome:24086 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0001843 name: MAP kinase 1 activity namespace: molecular_function synonym: "ERK1" EXACT [] xref: EC:2.7.11.- xref: GO:0008338 is_a: CCO:F0001073 ! MAP kinase activity [Term] id: CCO:F0001844 name: MP kinase activity namespace: molecular_function synonym: "Mpk2" NARROW [] synonym: "p38" NARROW [] synonym: "SAPK2" NARROW [] xref: EC:2.7.11.- xref: GO:0008339 is_a: CCO:F0003465 ! SAP kinase activity [Term] id: CCO:F0001845 name: MAP kinase kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549] synonym: "MAPKKKK" EXACT [] xref: EC:2.7.11.- xref: GO:0008349 is_a: CCO:F0001068 ! receptor signaling protein serine/threonine kinase activity [Term] id: CCO:F0001846 name: RNA polymerase subunit kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase) = ADP + phospho-(DNA-directed RNA polymerase)." [EC:2.7.11.23] synonym: "[RNA-polymerase]-subunit kinase activity" EXACT [] synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" EXACT [EC:2.7.11.23] synonym: "CTD kinase activity" NARROW [EC:2.7.11.23] synonym: "RNA-polymerase-subunit kinase activity" EXACT [EC:2.7.11.23] synonym: "STK9" RELATED [EC:2.7.11.23] xref: EC:2.7.11.23 xref: GO:0008353 xref: MetaCyc:[RNA-POLYMERASE\]-SUBUNIT-KINASE-RXN is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001847 name: bacterial binding namespace: molecular_function def: "Interacting selectively with any part of a bacterial cell." [GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "bacterium binding" EXACT [] synonym: "binding to bacterium" EXACT [] xref: GO:0008367 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0001848 name: Gram-negative bacterial binding namespace: molecular_function def: "Interacting selectively with any part of a Gram-negative bacterial cell." [GOC:jl] subset: gosubset_prok synonym: "binding to Gram-negative bacterium" EXACT [] synonym: "Gram-negative bacterium binding" EXACT [] xref: GO:0008368 is_a: CCO:F0001847 ! bacterial binding [Term] id: CCO:F0001849 name: sialyltransferase activity namespace: molecular_function def: "Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: EC:2.4.99.- xref: GO:0008373 is_a: CCO:F0003332 ! transferase activity, transferring glycosyl groups [Term] id: CCO:F0001850 name: O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0008374 xref: Reactome:1150 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0001851 name: acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to an oligosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GlcNAc transferase activity" EXACT [] xref: EC:2.4.1.- xref: GO:0008375 is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0001852 name: acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "GalNAc transferase activity" EXACT [] xref: EC:2.4.1.- xref: GO:0008376 is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0001853 name: galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.4.1.- xref: GO:0008378 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0001854 name: thioredoxin peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267] subset: gosubset_prok synonym: "thiol peroxidase activity" EXACT [] synonym: "TPx activity" EXACT [] synonym: "TrxPx activity" EXACT [] xref: EC:1.11.1.- xref: GO:0008379 xref: GO:0009031 xref: MetaCyc:RXN0-267 is_a: CCO:F0008212 ! peroxiredoxin activity [Term] id: CCO:F0001855 name: mechanically-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0008381 is_a: CCO:F0001492 ! ion channel activity is_a: CCO:F0004265 ! mechanically gated channel activity [Term] id: CCO:F0001856 name: IkappaB kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10] comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. The kinase is composed of alpha, beta and gamma subunits, of which the latter does not have kinase activity but is presumed to play a regulatory role. synonym: "ATP:IkappaB protein phosphotransferase activity" EXACT [EC:2.7.11.10] synonym: "CHUK" RELATED [EC:2.7.11.10] synonym: "ikappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "IKBKA" RELATED [EC:2.7.11.10] synonym: "IKBKB" RELATED [EC:2.7.11.10] synonym: "IKK" RELATED [EC:2.7.11.10] synonym: "IKK-1" RELATED [EC:2.7.11.10] synonym: "IKK-2" RELATED [EC:2.7.11.10] synonym: "inhibitor of NF-kappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "inhibitor of NFkappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "STK12" RELATED [EC:2.7.11.10] synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10] synonym: "TBK1" RELATED [EC:2.7.11.10] xref: EC:2.7.11.10 xref: GO:0008384 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0001857 name: cholesterol monooxygenase (side-chain-cleaving) activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6] synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6] synonym: "cholesterol 20-22-desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C(20-22) desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C20-22 desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" EXACT [EC:1.14.15.6] synonym: "Cyp11a1" NARROW [] synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6] synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6] synonym: "desmolase, steroid 20-22" EXACT [EC:1.14.15.6] synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6] synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6] synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6] xref: EC:1.14.15.6 xref: GO:0008386 xref: MetaCyc:1.14.15.6-RXN is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0001858 name: steroid 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP2A12" NARROW [] xref: GO:0008387 is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001859 name: testosterone 15-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2A4" NARROW [] xref: GO:0008388 is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001860 name: coumarin 7-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [Reactome:163103] synonym: "cytochrome P450 CYP2A5" NARROW [] xref: GO:0008389 xref: Reactome:24222 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001861 name: testosterone 16-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2B10" NARROW [] synonym: "cytochrome P450 CYP2B9" NARROW [] synonym: "cytochrome P450 CYP2D10" NARROW [] synonym: "cytochrome P450 CYP2D11" NARROW [] synonym: "cytochrome P450 CYP2D9" NARROW [] xref: GO:0008390 is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001862 name: arachidonic acid monooxygenase activity namespace: molecular_function synonym: "cytochrome P450 CYP2B19" NARROW [] xref: GO:0008391 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001863 name: arachidonic acid epoxygenase activity namespace: molecular_function synonym: "cytochrome P450 CYP2J5" NARROW [] synonym: "cytochrome P450 CYP2J6" NARROW [] xref: GO:0008392 is_a: CCO:F0001862 ! arachidonic acid monooxygenase activity [Term] id: CCO:F0001864 name: fatty acid (omega-1)-hydroxylase activity namespace: molecular_function synonym: "cytochrome P450 CYP2E1" NARROW [] xref: GO:0008393 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001865 name: olfactory-specific steroid hydroxylase activity namespace: molecular_function synonym: "cytochrome P450 CYP2G1" NARROW [] xref: GO:0008394 is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001866 name: steroid hydroxylase activity namespace: molecular_function def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: GO:0008395 is_a: CCO:F0000894 ! monooxygenase activity [Term] id: CCO:F0001867 name: oxysterol 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791] synonym: "cytochrome P450 CYP7B1" NARROW [] xref: GO:0008396 is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001868 name: sterol 12-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP8B1" NARROW [] xref: GO:0008397 is_a: CCO:F0001866 ! steroid hydroxylase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001869 name: sterol 14-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [EC:1.14.13.70] subset: gosubset_prok synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.13.70] synonym: "cytochrome P450 CYP51" NARROW [] synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70] xref: EC:1.14.13.70 xref: GO:0008398 xref: MetaCyc:1.14.13.70-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen is_a: CCO:F0004997 ! demethylase activity [Term] id: CCO:F0001870 name: naphthalene hydroxylase activity namespace: molecular_function synonym: "cytochrome P450 CYP2F2" NARROW [] xref: GO:0008399 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001871 name: retinoic acid 4-hydroxylase activity namespace: molecular_function synonym: "cytochrome P450 CYP261" NARROW [] xref: GO:0008401 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001872 name: 25-hydroxycholecalciferol-24-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycalciferol." [ISBN:0471331309 "Biochemical Pathways"] synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT [] synonym: "cytochrome P450 CYP24" NARROW [] xref: GO:0008403 xref: GO:0030344 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0001873 name: arachidonic acid 14,15-epoxygenase activity namespace: molecular_function synonym: "cytochrome P450 CYP2C29" NARROW [] synonym: "cytochrome P450 CYP2C39" NARROW [] xref: GO:0008404 is_a: CCO:F0001862 ! arachidonic acid monooxygenase activity [Term] id: CCO:F0001874 name: arachidonic acid 11,12-epoxygenase activity namespace: molecular_function synonym: "cytochrome P450 CYP2C38" NARROW [] xref: GO:0008405 is_a: CCO:F0001862 ! arachidonic acid monooxygenase activity [Term] id: CCO:F0001875 name: 3'-5' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] subset: gosubset_prok synonym: "3'-5'-exonuclease activity" EXACT [] xref: GO:0008408 is_a: CCO:F0000923 ! exonuclease activity [Term] id: CCO:F0001876 name: 5'-3' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai] subset: gosubset_prok xref: GO:0008409 is_a: CCO:F0000923 ! exonuclease activity [Term] id: CCO:F0001877 name: CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.8.3.- xref: GO:0008410 is_a: CCO:F0003354 ! transferase activity, transferring sulfur-containing groups [Term] id: CCO:F0001878 name: 4-hydroxybutyrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl] subset: gosubset_prok xref: GO:0008411 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0001879 name: 4-hydroxybenzoate octaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: farnesylfarnesylgeranyl-PP + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN] subset: gosubset_prok synonym: "4-HB polyprenyltransferase activity" EXACT [] synonym: "para-hydroxybenzoate transferase activity" EXACT [] synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT [] synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT [] synonym: "PHB polyprenyl diphosphate transferase activity" EXACT [] xref: EC:2.5.1.- xref: GO:0000043 xref: GO:0008412 xref: GO:0048043 xref: GO:0048044 xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN is_a: CCO:F0000268 ! polyprenyltransferase activity [Term] id: CCO:F0001880 name: 8-oxo-7,8-dihydroguanine triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanine triphosphate = 8-oxo-7,8-dihydroguanine phosphate + diphosphate." [PMID:7782328] subset: gosubset_prok synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT [] synonym: "8-oxo-GTPase activity" EXACT [] xref: EC:3.6.1.- xref: GO:0008413 is_a: CCO:F0003574 ! nucleoside-triphosphatase activity [Term] id: CCO:F0001881 name: CDP-alcohol phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl] xref: GO:0008414 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0001882 name: acyltransferase activity namespace: molecular_function def: "Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier." [EC:2.3.1.-, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0008415 xref: Reactome:1091 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0001883 name: delta5-delta2,4-dienoyl-CoA isomerase activity namespace: molecular_function xref: EC:5.3.3.- xref: GO:0008416 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0001884 name: fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok xref: EC:2.4.1.- xref: GO:0008417 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0001885 name: protein N-terminal asparagine amidohydrolase activity namespace: molecular_function xref: EC:3.5.1.- xref: GO:0008418 is_a: CCO:F0000542 ! asparaginase activity [Term] id: CCO:F0001886 name: RNA lariat debranching enzyme activity namespace: molecular_function xref: GO:0008419 is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0001887 name: CTD phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [EC:3.1.3.16] xref: GO:0008420 is_a: CCO:F0001087 ! protein serine/threonine phosphatase activity [Term] id: CCO:F0001888 name: long-chain-fatty-acyl-glutamate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55] synonym: "long-chain acylglutamate amidase activity" EXACT [EC:3.5.1.55] synonym: "long-chain aminoacylase activity" EXACT [EC:3.5.1.55] synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55] xref: EC:3.5.1.55 xref: GO:0008421 xref: MetaCyc:3.5.1.55-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0001889 name: beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21] subset: gosubset_prok synonym: "amygdalase activity" NARROW [EC:3.2.1.21] synonym: "amygdalinase" BROAD [EC:3.2.1.21] synonym: "arbutinase activity" EXACT [EC:3.2.1.21] synonym: "aryl-beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-1,6-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "beta-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "cellobiase activity" NARROW [EC:3.2.1.21] synonym: "elaterase activity" NARROW [EC:3.2.1.21] synonym: "emulsin" RELATED [EC:3.2.1.21] synonym: "gentiobiase activity" NARROW [EC:3.2.1.21] synonym: "gentobiase activity" NARROW [EC:3.2.1.21] synonym: "limarase activity" NARROW [EC:3.2.1.21] synonym: "p-nitrophenyl beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "primeverosidase activity" NARROW [EC:3.2.1.21] synonym: "salicilinase activity" NARROW [EC:3.2.1.21] xref: EC:3.2.1.21 xref: GO:0008422 xref: MetaCyc:3.2.1.21-RXN is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0001890 name: bleomycin hydrolase activity namespace: molecular_function def: "Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40] subset: gosubset_prok synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40] xref: EC:3.4.22.40 xref: GO:0008423 xref: MetaCyc:3.4.22.40-RXN is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0001891 name: glycoprotein 6-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine." [EC:2.4.1.68] synonym: "FucT" RELATED [EC:2.4.1.68] synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDPfucose-glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68] synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] xref: EC:2.4.1.68 xref: GO:0008424 xref: MetaCyc:2.4.1.68-RXN is_a: CCO:F0006273 ! alpha(1,6)-fucosyltransferase activity [Term] id: CCO:F0001892 name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] subset: gosubset_prok synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT [] synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT [] synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD [] synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD [] xref: EC:2.1.1.- xref: GO:0008425 is_a: CCO:F0004484 ! quinone cofactor methyltransferase activity [Term] id: CCO:F0001893 name: protein kinase C inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai] synonym: "PKC inhibitor activity" EXACT [] xref: GO:0008426 is_a: CCO:F0004378 ! protein serine/threonine kinase inhibitor activity [Term] id: CCO:F0001894 name: calcium-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah] xref: GO:0008427 is_a: CCO:F0001216 ! protein kinase inhibitor activity [Term] id: CCO:F0001895 name: ribonuclease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai] subset: gosubset_prok xref: GO:0008428 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0001896 name: phosphatidylethanolamine binding namespace: molecular_function def: "Interacting selectively with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0008429 is_a: CCO:F0001666 ! phospholipid binding [Term] id: CCO:F0001897 name: selenium binding namespace: molecular_function def: "Interacting selectively with selenium (Se)." [GOC:ai] subset: gosubset_prok xref: GO:0008430 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0001898 name: vitamin E binding namespace: molecular_function def: "Interacting selectively with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "alpha-tocopherol binding" NARROW [] synonym: "tocopherol binding" EXACT [] xref: GO:0008431 is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0001899 name: JUN kinase binding namespace: molecular_function def: "Interacting selectively with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl] xref: GO:0008432 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0001900 name: vitamin D3 receptor activity namespace: molecular_function def: "Combining with vitamin D3, cholecalciferol, to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. synonym: "cholecaliferol receptor activity" EXACT [] xref: GO:0008434 is_a: CCO:F0001233 ! ligand-dependent nuclear receptor activity [Term] id: CCO:F0001901 name: thyrotropin-releasing hormone activity namespace: molecular_function xref: GO:0008437 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0001902 name: monophenol monooxygenase activator activity namespace: molecular_function def: "Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai] synonym: "prophenol oxidase activator" RELATED [] xref: GO:0008439 is_a: CCO:F0000698 ! serine-type endopeptidase activity is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0001903 name: inositol trisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate." [EC:2.7.1.127] synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.127] synonym: "inositol 1,4,5-trisphosphate 3-kinase activity" EXACT [] synonym: "inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ins(1,4,5)P(3) 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "Ins(1,4,5)P3 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127] synonym: "IP3K activity" NARROW [EC:2.7.1.127] xref: EC:2.7.1.127 xref: GO:0008440 xref: MetaCyc:2.7.1.127-RXN is_a: CCO:F0008191 ! inositol trisphosphate kinase activity [Term] id: CCO:F0001904 name: 3'(2'),5'-bisphosphate nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7] subset: gosubset_prok synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT [] synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" EXACT [EC:3.1.3.7] synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "DPNPase activity" EXACT [EC:3.1.3.7] synonym: "phosphoadenylate 3'-nucleotidase activity" EXACT [EC:3.1.3.7] xref: EC:3.1.3.7 xref: GO:0008441 xref: MetaCyc:3 xref: Reactome:24620 is_a: CCO:F0001795 ! nucleotidase activity [Term] id: CCO:F0001905 name: 3-hydroxyisobutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31] subset: gosubset_prok xref: EC:1.1.1.31 xref: GO:0008442 xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN xref: Reactome:24621 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001906 name: phosphofructokinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule." [GOC:jl] subset: gosubset_prok xref: EC:2.7.1.- xref: GO:0008443 is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0001907 name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate." [EC:2.7.8.5] subset: gosubset_prok synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol 3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerophosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "PGP synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerolphosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] xref: EC:2.7.8.5 xref: GO:0008444 xref: MetaCyc:PHOSPHAGLYPSYN-RXN is_a: CCO:F0003607 ! CDP-alcohol phosphatidyltransferase activity [Term] id: CCO:F0001908 name: D-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.1] synonym: "aspartic oxidase activity" EXACT [EC:1.4.3.1] synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.1] synonym: "D-aspartic oxidase activity" EXACT [EC:1.4.3.1] xref: EC:1.4.3.1 xref: GO:0008445 xref: MetaCyc:D-ASPARTATE-OXIDASE-RXN is_a: CCO:F0003017 ! aspartate oxidase activity [Term] id: CCO:F0001909 name: GDP-mannose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O." [EC:4.2.1.47] subset: gosubset_prok synonym: "GDP-D-mannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-D-mannose dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.47] synonym: "GDPmannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "Gmd" RELATED [EC:4.2.1.47] synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose oxidoreductase activity" EXACT [EC:4.2.1.47] xref: EC:4.2.1.47 xref: GO:0008446 xref: MetaCyc:GDPMANDEHYDRA-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0001910 name: L-ascorbate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3] synonym: "AA oxidase activity" EXACT [EC:1.10.3.3] synonym: "AAO" RELATED [EC:1.10.3.3] synonym: "ascorbase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate dehydrogenase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic oxidase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:O2 oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] xref: EC:1.10.3.3 xref: GO:0008447 xref: MetaCyc:L-ASCORBATE-OXIDASE-RXN is_a: CCO:F0003273 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: CCO:F0001911 name: N-acetylglucosamine-6-phosphate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25] subset: gosubset_prok synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylglucosamine phosphate deacetylase activity" EXACT [EC:3.5.1.25] synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] xref: EC:3.5.1.25 xref: GO:0008448 xref: MetaCyc:NAG6PDEACET-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0001912 name: N-acetylglucosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14] subset: gosubset_prok synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "acetylglucosamine 6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14] synonym: "glucosamine-6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT [] synonym: "O,N-disulfate O-sulfohydrolase activity" EXACT [EC:3.1.6.14] xref: EC:3.1.6.14 xref: GO:0008449 xref: MetaCyc:3.1.6.14-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0001913 name: O-sialoglycoprotein endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [EC:3.4.24.57] subset: gosubset_prok synonym: "glycophorin A proteinase activity" EXACT [EC:3.4.24.57] synonym: "glycoprotease activity" RELATED [EC:3.4.24.57] synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57] synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57] synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57] xref: EC:3.4.24.57 xref: GO:0008450 xref: MetaCyc:3.4.24.57-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0001914 name: X-Pro aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9] subset: gosubset_prok synonym: "aminoacylproline aminopeptidase activity" EXACT [EC:3.4.11.9] synonym: "aminopeptidase P" EXACT [] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9] synonym: "Xaa-Pro aminopeptidase activity" EXACT [] xref: EC:3.4.11.9 xref: GO:0008451 xref: MetaCyc:3.4.11.9-RXN is_a: CCO:F0000646 ! aminopeptidase activity [Term] id: CCO:F0001915 name: RNA ligase activity namespace: molecular_function subset: gosubset_prok xref: EC:6.5.1.- xref: GO:0008452 is_a: CCO:F0003444 ! ligase activity, forming phosphoric ester bonds [Term] id: CCO:F0001916 name: alanine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44] subset: gosubset_prok synonym: "AGT activity" EXACT [EC:2.6.1.44] synonym: "alanine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "alanine-glyoxylate aminotransferase activity" EXACT [] synonym: "alanine-glyoxylic aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine-glycine transaminase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] xref: EC:2.6.1.44 xref: GO:0008453 xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0001917 name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145] synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "beta-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "GnTIV activity" EXACT [EC:2.4.1.145] synonym: "N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145] xref: EC:2.4.1.145 xref: GO:0008454 xref: MetaCyc:2.4.1.145-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0001918 name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143] synonym: "acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTII activity" EXACT [EC:2.4.1.143] synonym: "N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha-1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] xref: EC:2.4.1.143 xref: GO:0008455 xref: MetaCyc:2.4.1.143-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0001919 name: alpha-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49] synonym: "alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49] synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.49] synonym: "alpha-NAGA activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49] xref: EC:3.2.1.49 xref: GO:0008456 xref: MetaCyc:3.2.1.49-RXN is_a: CCO:F0003024 ! hexosaminidase activity [Term] id: CCO:F0001920 name: beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [EC:2.4.1.163] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.163] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.163] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.163] xref: EC:2.4.1.163 xref: GO:0008457 xref: MetaCyc:2.4.1.163-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0001921 name: carnitine O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine." [EC:2.3.1.137] synonym: "carnitine medium-chain acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] synonym: "medium-chain/long-chain carnitine acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" EXACT [EC:2.3.1.137] synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] xref: EC:2.3.1.137 xref: GO:0008458 xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN is_a: CCO:F0003129 ! carnitine O-acyltransferase activity is_a: CCO:F0003137 ! O-octanoyltransferase activity [Term] id: CCO:F0001922 name: chondroitin 6-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-O-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-sulphotransferase activity" EXACT [] synonym: "terminal 6-sulfotransferase activity" EXACT [EC:2.8.2.17] xref: EC:2.8.2.17 xref: GO:0008459 xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0001923 name: dTDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.46] subset: gosubset_prok synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.46] synonym: "dTDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "TDP-glucose oxidoreductase activity" EXACT [EC:4.2.1.46] synonym: "thymidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.46] xref: EC:4.2.1.46 xref: GO:0008460 xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0001924 name: endopeptidase Clp activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [EC:3.4.21.92] subset: gosubset_prok synonym: "ATP-dependent Clp protease" NARROW [EC:3.4.21.92] synonym: "caseinolytic protease activity" RELATED [EC:3.4.21.92] synonym: "Clp protease" NARROW [EC:3.4.21.92] synonym: "ClpP" RELATED [EC:3.4.21.92] synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92] synonym: "protease Ti activity" RELATED [EC:3.4.21.92] xref: EC:3.4.21.92 xref: GO:0008462 xref: MetaCyc:3.4.21.92-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0001925 name: formylmethionine deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-methionine + H2O = formate + L-methionine." [EC:3.5.1.31] subset: gosubset_prok synonym: "N-formyl-L-methionine amidohydrolase activity" EXACT [EC:3.5.1.31] xref: EC:3.5.1.31 xref: GO:0008463 xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0001926 name: gamma-glutamyl hydrolase activity namespace: molecular_function def: "Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9] synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9] synonym: "conjugase activity" RELATED [EC:3.4.19.9] synonym: "folate conjugase activity" RELATED [EC:3.4.19.9] synonym: "folic acid conjugase activity" EXACT [EC:3.4.19.9] synonym: "gamma-Glu-X carboxypeptidase activity" EXACT [EC:3.4.19.9] synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9] synonym: "poly(gamma-glutamic acid) endohydrolase activity" EXACT [EC:3.4.19.9] synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9] synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9] synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] xref: EC:3.4.19.9 xref: GO:0008464 xref: MetaCyc:3.4.19.9-RXN is_a: CCO:F0001792 ! omega peptidase activity [Term] id: CCO:F0001927 name: glycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+." [EC:1.1.1.29] subset: gosubset_prok synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29] xref: EC:1.1.1.29 xref: GO:0008465 xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0001928 name: glycogenin glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186] synonym: "glycogenin activity" RELATED [EC:2.4.1.186] synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186] synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.186] synonym: "UDP-glucose:glycogenin glucosyltransferase activity" EXACT [EC:2.4.1.186] xref: EC:2.4.1.186 xref: GO:0008466 xref: MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN xref: Reactome:24685 is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0001929 name: heparin-glucosamine 3-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparin-glucosamine = adenosine 3',5'-bisphosphate + heparin-glucosamine 3-O-sulfate." [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "3-OST-1 activity" EXACT [EC:2.8.2.23] synonym: "[heparan sulfate]-glucosamine 3-sulfotransferase 1" RELATED [EC:2.8.2.23] synonym: "glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparin-glucosamine 3-O-sulphotransferase activity" EXACT [] synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23] xref: EC:2.8.2.23 xref: GO:0008467 xref: MetaCyc:2.8.2.23-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0001930 name: histone-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N-methyl-arginine." [EC:2.1.1.125] synonym: "histone protein methylase activity" EXACT [EC:2.1.1.125] synonym: "histone protein methylase I" RELATED [EC:2.1.1.125] synonym: "nuclear protein (histone) N-methyltransferase activity" EXACT [EC:2.1.1.125] synonym: "protein methylase I activity" BROAD [EC:2.1.1.125] synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.125] synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.125] xref: EC:2.1.1.125 xref: GO:0008469 xref: GO:0016276 xref: MetaCyc:2.1.1.125-RXN is_a: CCO:F0003096 ! protein-arginine N-methyltransferase activity is_a: CCO:F0005616 ! histone methyltransferase activity [Term] id: CCO:F0001931 name: isovaleryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.99.10] subset: gosubset_prok synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.10] synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.10] synonym: "isovaleroyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] synonym: "isovaleryl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] xref: EC:1.3.99.10 xref: GO:0008470 xref: MetaCyc:ISOVALERYL-COA-DEHYDROGENASE-RXN xref: Reactome:24705 is_a: CCO:F0000480 ! acyl-CoA dehydrogenase activity [Term] id: CCO:F0001932 name: laccase activity namespace: molecular_function def: "Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2] subset: gosubset_prok synonym: "benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.2] synonym: "p-diphenol oxidase activity" EXACT [EC:1.10.3.2] synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2] synonym: "urushiol oxidase activity" EXACT [EC:1.10.3.2] xref: EC:1.10.3.2 xref: GO:0008471 xref: MetaCyc:LACCASE-RXN is_a: CCO:F0003273 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: CCO:F0001933 name: metallocarboxypeptidase D activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22] synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22] synonym: "gp180 (duck)" RELATED [EC:3.4.17.22] xref: EC:3.4.17.22 xref: GO:0008472 xref: MetaCyc:3.4.17.22-RXN is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0001934 name: ornithine cyclodeaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = L-proline + NH3." [EC:4.3.1.12] subset: gosubset_prok synonym: "L-ornithine ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.12] synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" EXACT [EC:4.3.1.12] synonym: "OCD activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase (deaminating) activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase activity" EXACT [EC:4.3.1.12] xref: EC:4.3.1.12 xref: GO:0008473 xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN is_a: CCO:F0003406 ! ammonia-lyase activity is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0001935 name: palmitoyl-(protein) hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22] synonym: "palmitoyl-protein hydrolase activity" EXACT [] synonym: "palmitoyl-protein thioesterase activity" EXACT [] synonym: "palmitoyl-protein thiolesterase activity" EXACT [] xref: EC:3.1.2.22 xref: GO:0008474 xref: MetaCyc:3.1.2.22-RXN is_a: CCO:F0003361 ! thiolester hydrolase activity [Term] id: CCO:F0001936 name: procollagen-lysine 5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4] synonym: "collagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4] synonym: "lysine-2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity" EXACT [EC:1.14.11.4] synonym: "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.11.4] synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.11.4] synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4] xref: EC:1.14.11.4 xref: GO:0008475 xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0001937 name: protein-tyrosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20] synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" EXACT [EC:2.8.2.20] synonym: "protein-tyrosine sulphotransferase activity" EXACT [] synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20] xref: EC:2.8.2.20 xref: GO:0008476 xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0001938 name: purine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1] subset: gosubset_prok synonym: "IAG-NH activity" RELATED [EC:3.2.2.1] synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1] synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1] synonym: "N-D-ribosylpurine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "N-ribosyl purine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "nucleosidase activity" BROAD [EC:3.2.2.1] synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1] synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1] synonym: "purine beta-ribosidase activity" EXACT [EC:3.2.2.1] synonym: "purine nucleosidase reaction" EXACT [] synonym: "purine nucleoside hydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine ribonucleosidase activity" EXACT [EC:3.2.2.1] synonym: "purine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1] xref: EC:3.2.2.1 xref: GO:0008477 xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0001939 name: pyridoxal kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] subset: gosubset_prok synonym: "ATP:pyridoxal 5'-phosphotransferase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal 5-phosphate-kinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal kinase (phosphorylating)" EXACT [EC:2.7.1.35] synonym: "pyridoxal phosphokinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35] synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35] xref: EC:2.7.1.35 xref: GO:0008478 xref: MetaCyc:PYRIDOXKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0001940 name: queuine tRNA-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29] subset: gosubset_prok synonym: "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "guanine insertion enzyme activity" RELATED [EC:2.4.2.29] synonym: "guanine, queuine-tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "Q-insertase activity" EXACT [EC:2.4.2.29] synonym: "queuine transfer ribonucleate ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "transfer ribonucleate glycosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "tRNA guanine transglycosidase activity" EXACT [EC:2.4.2.29] synonym: "tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29] xref: EC:2.4.2.29 xref: GO:0008479 xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0001941 name: sarcosine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor." [EC:1.5.99.1] subset: gosubset_prok synonym: "monomethylglycine dehydrogenase activity" EXACT [EC:1.5.99.1] synonym: "sarcosine N-demethylase activity" EXACT [EC:1.5.99.1] synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.1] synonym: "sarcosine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.1] xref: EC:1.5.99.1 xref: GO:0008480 xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0001942 name: sphinganine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [EC:2.7.1.91] synonym: "ATP:sphinganine 1-phosphotransferase activity" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase activity" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase activity" RELATED [] xref: EC:2.7.1.91 xref: GO:0001728 xref: GO:0008481 xref: MetaCyc:SPHINGANINE-KINASE-RXN is_a: CCO:F0000204 ! lipid kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0001943 name: sulfite oxidase activity namespace: molecular_function def: "Catalysis of the reaction: SO3(2-) (sulfite) + O2 + H2O = SO4(2-) (sulfate) + H2O2." [EC:1.8.3.1] subset: gosubset_prok synonym: "sulfite:oxygen oxidoreductase activity" EXACT [EC:1.8.3.1] synonym: "sulphite oxidase activity" EXACT [] xref: EC:1.8.3.1 xref: GO:0008482 xref: MetaCyc:PWY-5326 xref: MetaCyc:SULFITE-OXIDASE-RXN is_a: CCO:F0003263 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor [Term] id: CCO:F0001944 name: transaminase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminotransferase activity" EXACT [] xref: EC:2.6.1 xref: GO:0008483 is_a: CCO:F0003342 ! transferase activity, transferring nitrogenous groups [Term] id: CCO:F0001945 name: sulfuric ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] subset: gosubset_prok synonym: "sulfatase activity" EXACT [] synonym: "sulphuric ester hydrolase activity" EXACT [] xref: EC:3.1.6 xref: GO:0008484 is_a: CCO:F0003360 ! hydrolase activity, acting on ester bonds [Term] id: CCO:F0001946 name: diphosphoinositol-polyphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52] synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.52e] synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT [] synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.52e] synonym: "DIPP activity" EXACT [EC:3.6.1.52e] xref: EC:3.6.1.52e xref: GO:0008486 xref: MetaCyc:3.6.1.52-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0001947 name: prenyl-dependent CAAX protease activity namespace: molecular_function xref: GO:0008487 is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0001948 name: gamma-glutamyl carboxylase activity namespace: molecular_function subset: gosubset_prok xref: EC:4.1.1.- xref: GO:0008488 xref: Reactome:24735 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0001949 name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + glucosylceramide = lactosylceramide (galactosyl-beta-1,4-glucosylceramide) + UDP." [GOC:ai, PMID:9593693] synonym: "LacCer synthase activity" EXACT [] synonym: "lactosylceramide synthase activity" EXACT [] synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT [] xref: GO:0008489 is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0001950 name: arsenite secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl] subset: gosubset_prok synonym: "arsenite porter activity" RELATED [] xref: GO:0008490 xref: GO:0008491 is_a: CCO:F0002583 ! arsenite transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0001951 name: tetracycline transporter activity namespace: molecular_function def: "Enables the directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "tetracyclin transporter activity" EXACT [] xref: GO:0008493 is_a: CCO:F0005732 ! antibiotic transporter activity [Term] id: CCO:F0001952 name: translation activator activity namespace: molecular_function def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai] xref: GO:0008494 is_a: CCO:F0001739 ! translation factor activity, nucleic acid binding [Term] id: CCO:F0001953 name: protoheme IX farnesyltransferase activity namespace: molecular_function subset: gosubset_prok synonym: "haem O synthase activity" EXACT [] synonym: "heme O synthase activity" EXACT [] synonym: "protohaem IX farnesyltransferase activity" EXACT [] xref: EC:2.5.1.- xref: GO:0008495 is_a: CCO:F0000732 ! farnesyltranstransferase activity [Term] id: CCO:F0001954 name: mannan endo-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,6-alpha-D-mannosidic linkages in unbranched 1,6-mannans." [EC:3.2.1.101] synonym: "1,6-alpha-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "1,6-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "endo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-1->6-D-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-D-mannosidase activity" EXACT [] synonym: "exo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "mannan endo-1,6-beta-mannosidase activity" EXACT [EC:3.2.1.101] xref: EC:3.2.1.101 xref: GO:0008496 xref: MetaCyc:3.2.1.101-RXN is_a: CCO:F0000944 ! alpha-mannosidase activity [Term] id: CCO:F0001955 name: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP." [PMID:10212226] synonym: "beta-1,3-GalTase activity" BROAD [] synonym: "beta3Gal-Ts activity" BROAD [] synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT [] xref: GO:0008499 is_a: CCO:F0005579 ! UDP-galactosyltransferase activity is_a: CCO:F0007345 ! beta-1,3-galactosyltransferase activity [Term] id: CCO:F0001956 name: melatonin receptor activity namespace: molecular_function def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0008502 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0001957 name: benzodiazepine receptor activity namespace: molecular_function def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. xref: GO:0008503 is_a: CCO:F0004488 ! neurotransmitter receptor activity [Term] id: CCO:F0001958 name: monoamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of monoamines, organic compounds containing one amino group, from one side of the membrane to the other." [GOC:ai] xref: GO:0008504 xref: GO:0015201 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0001959 name: sucrose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3] synonym: "hydrogen/sucrose transporter" RELATED [] synonym: "sucrose:proton symporter" EXACT [] xref: GO:0008506 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0001968 ! sucrose transmembrane transporter activity [Term] id: CCO:F0001960 name: sodium:iodide symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1] synonym: "sodium/iodide symporter" EXACT [] xref: GO:0008507 is_a: CCO:F0002799 ! monovalent anion:sodium symporter activity [Term] id: CCO:F0001961 name: bile acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-] synonym: "sodium/bile acid symporter" EXACT [] xref: GO:0008508 is_a: CCO:F0001571 ! organic acid:sodium symporter activity is_a: CCO:F0002602 ! bile acid transmembrane transporter activity [Term] id: CCO:F0001962 name: anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:def, GOC:df, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "anion transporter activity" EXACT [] xref: GO:0008509 xref: Reactome:3160 is_a: CCO:F0002557 ! ion transmembrane transporter activity [Term] id: CCO:F0001963 name: sodium:bicarbonate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1] synonym: "sodium/bicarbonate cotransporter" EXACT [] synonym: "sodium:bicarbonate cotransporter activity" EXACT [] xref: GO:0008510 is_a: CCO:F0002584 ! bicarbonate transmembrane transporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0001964 name: sodium:potassium:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1] synonym: "sodium/potassium/chloride symporter" EXACT [] xref: GO:0008511 is_a: CCO:F0002802 ! cation:chloride symporter activity [Term] id: CCO:F0001965 name: sulfate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-] synonym: "sulfate/hydrogen symporter" EXACT [] synonym: "sulfate:proton symporter" EXACT [] synonym: "sulphate:hydrogen symporter activity" EXACT [] xref: GO:0008512 is_a: CCO:F0001811 ! secondary active sulfate transmembrane transporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0001966 name: secondary active organic cation transmembrane transporter activity namespace: molecular_function synonym: "organic cation porter activity" RELATED [] xref: GO:0008513 is_a: CCO:F0002580 ! organic cation transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0001967 name: organic anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] subset: gosubset_prok xref: GO:0008514 is_a: CCO:F0001962 ! anion transmembrane transporter activity [Term] id: CCO:F0001968 name: sucrose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "sucrose permease (PTS) activity" EXACT [] synonym: "sucrose permease activity" RELATED [] xref: GO:0008515 xref: GO:0019188 is_a: CCO:F0002631 ! disaccharide transmembrane transporter activity [Term] id: CCO:F0001969 name: hexose uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5] xref: GO:0008516 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002626 ! hexose transmembrane transporter activity is_a: CCO:F0002741 ! uniporter activity [Term] id: CCO:F0001970 name: folic acid transporter activity namespace: molecular_function def: "Enables the directed movement of folic acid (pteroylglutamic acid) into, out of, within or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transporter activity" EXACT [] synonym: "vitamin B9 transporter activity" EXACT [] synonym: "vitamin M transporter activity" EXACT [] xref: GO:0008517 is_a: CCO:F0008065 ! vitamin transporter activity is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0001971 name: reduced folate carrier activity namespace: molecular_function def: "Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "reduced folate transporter" BROAD [] xref: GO:0008518 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0001972 name: ammonium transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0008519 is_a: CCO:F0002580 ! organic cation transmembrane transporter activity is_a: CCO:F0004309 ! inorganic cation transmembrane transporter activity [Term] id: CCO:F0001973 name: L-ascorbate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in)." [TC:2.A.40.6.1] synonym: "sodium-dependent L-ascorbic acid transporter" RELATED [] xref: GO:0008520 is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001974 name: acetyl-CoA transporter activity namespace: molecular_function def: "Enables the directed movement of acetyl-CoA into, out of, within or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] xref: GO:0008521 is_a: CCO:F0008067 ! coenzyme transporter activity [Term] id: CCO:F0001975 name: sodium-dependent multivitamin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2] xref: GO:0008523 is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0001976 name: glucose 6-phosphate:phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)." [TC:2.A.1.-.-] xref: GO:0008524 is_a: CCO:F0002750 ! anion:anion antiporter activity is_a: CCO:F0002761 ! organophosphate:inorganic phosphate antiporter activity [Term] id: CCO:F0001977 name: phosphatidylcholine transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of phosphatidylcholine into, out of, within or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0008525 is_a: CCO:F0001671 ! phospholipid transporter activity [Term] id: CCO:F0001978 name: phosphatidylinositol transporter activity namespace: molecular_function def: "Enables the directed movement of phosphatidylinositol into, out of, within or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "phosphatidylinositol transfer" EXACT [] xref: GO:0008526 is_a: CCO:F0001671 ! phospholipid transporter activity [Term] id: CCO:F0001979 name: taste receptor activity namespace: molecular_function def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] synonym: "gustatory receptor" EXACT [] xref: GO:0008527 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0001980 name: peptide receptor activity, G-protein coupled namespace: molecular_function synonym: "G protein coupled peptide receptor activity" EXACT [] synonym: "G-protein coupled peptide receptor activity" EXACT [] synonym: "G-protein-coupled peptide receptor activity" EXACT [] synonym: "peptide receptor activity, G protein coupled" EXACT [] xref: GO:0008528 is_a: CCO:F0000141 ! rhodopsin-like receptor activity is_a: CCO:F0000195 ! peptide receptor activity [Term] id: CCO:F0001981 name: riboflavin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN." [EC:2.7.1.26] subset: gosubset_prok synonym: "ATP:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.26] synonym: "FK" RELATED [EC:2.7.1.26] synonym: "flavokinase activity" EXACT [EC:2.7.1.26] synonym: "riboflavin kinase (phosphorylating)" EXACT [EC:2.7.1.26] synonym: "riboflavine kinase activity" EXACT [EC:2.7.1.26] xref: EC:2.7.1.26 xref: GO:0008531 xref: MetaCyc:RIBOFLAVINKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0001982 name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "GnTE activity" EXACT [EC:2.4.1.149] synonym: "N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149] synonym: "UDP-GlcNAc:Galbeta1->4GlcNAcbeta-rbeta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] xref: EC:2.4.1.149 xref: GO:0008532 xref: MetaCyc:2.4.1.149-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0001983 name: astacin activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [EC:3.4.24.21] subset: gosubset_prok synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21] synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21] synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21] xref: EC:3.4.24.21 xref: GO:0008533 xref: MetaCyc:3.4.24.21-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0001984 name: oxidized purine base lesion DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296] subset: gosubset_prok synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "8-oxoguanine DNA glycosylase activity" BROAD [] synonym: "bifunctional DNA glycosylase activity" BROAD [] synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23] synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23] synonym: "DNA glycosylase/AP-lyase activity" BROAD [] synonym: "DNA glycosylase/beta-lyase activity" BROAD [] synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT [] synonym: "fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT [] synonym: "Fpg protein" RELATED [EC:3.2.2.23] synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: EC:3.2.2.23 xref: GO:0003907 xref: GO:0008534 xref: MetaCyc:3.2.2.23-RXN xref: Reactome:24932 is_a: CCO:F0000095 ! oxidized base lesion DNA N-glycosylase activity is_a: CCO:F0000411 ! DNA-(apurinic or apyrimidinic site) lyase activity is_a: CCO:F0000917 ! endodeoxyribonuclease activity [Term] id: CCO:F0001985 name: Ran GTPase binding namespace: molecular_function def: "Interacting selectively with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly." [GOC:rn, PMID:12787777, PMID:14726649] synonym: "Ran protein binding" EXACT [] synonym: "Ran-binding protein" RELATED [] xref: GO:0008536 is_a: CCO:F0003512 ! Ras GTPase binding [Term] id: CCO:F0001986 name: proteasome activator activity namespace: molecular_function def: "Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771] synonym: "PA28" NARROW [] xref: GO:0008538 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0001987 name: proteasome inhibitor activity namespace: molecular_function synonym: "PI-31" NARROW [] xref: GO:0008539 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0001988 name: JUN kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549] synonym: "JNKK" EXACT [] xref: EC:2.7.11.- xref: GO:0008545 is_a: CCO:F0001074 ! MAP kinase kinase activity [Term] id: CCO:F0001989 name: cadmium-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out)." [EC:3.6.3.3] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (Cd2+-exporting)" EXACT [EC:3.6.3.3] synonym: "cadmium exporting ATPase activity" EXACT [] synonym: "cadmium-translocating P-type ATPase activity" RELATED [EC:3.6.3.3] synonym: "Cd(2+)-exporting ATPase activity" EXACT [EC:3.6.3.3] synonym: "Cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] synonym: "cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] xref: EC:3.6.3.3 xref: GO:0008551 xref: GO:0008561 xref: MetaCyc:3.6.3.3-RXN is_a: CCO:F0002566 ! cadmium ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0001990 name: hydrogen-exporting ATPase activity, phosphorylative mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism." [EC:3.6.3.6] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (H+-exporting)" EXACT [EC:3.6.3.6] synonym: "H(+)-exporting ATPase activity" BROAD [EC:3.6.3.6] synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.6] synonym: "H+-exporting ATPase activity" EXACT [EC:3.6.3.6] synonym: "H+-transporting ATPase" BROAD [EC:3.6.3.6] synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT [] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "proton transport ATPase activity" RELATED [EC:3.6.3.6] synonym: "proton-exporting ATPase" RELATED [EC:3.6.3.6] synonym: "proton-translocating ATPase activity" EXACT [EC:3.6.3.6] synonym: "proton-translocating P-type ATPase activity" EXACT [EC:3.6.3.6] synonym: "yeast plasma membrane ATPase" NARROW [EC:3.6.3.6] synonym: "yeast plasma membrane H+-ATPase" NARROW [EC:3.6.3.6] xref: EC:3.6.3.6 xref: GO:0008553 xref: MetaCyc:3.6.3.6-RXN is_a: CCO:F0002559 ! hydrogen ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0001991 name: sodium-exporting ATPase activity, phosphorylative mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism." [EC:3.6.3.7] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (Na+-exporting)" EXACT [EC:3.6.3.7] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "Na(+)-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "Na(+)-transporting ATPase activity" BROAD [EC:3.6.3.7] synonym: "Na+-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "Na+-transporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "sodium exporting ATPase activity, phosphorylative mechanism" EXACT [] synonym: "sodium transport ATPase activity" RELATED [EC:3.6.3.7] synonym: "sodium-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "sodium-translocating P-type ATPase activity" RELATED [EC:3.6.3.7] xref: EC:3.6.3.7 xref: GO:0008554 xref: MetaCyc:3.6.3.7-RXN is_a: CCO:F0002562 ! sodium ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0001992 name: chloride-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in)." [EC:3.6.3.11] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (Cl--importing)" EXACT [EC:3.6.3.11] synonym: "chloride ABC transporter" NARROW [] synonym: "chloride transporting ATPase activity" EXACT [] synonym: "chloride-motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "chloride-translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl(-)-transporting ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11] synonym: "cl--transporting ATPase activity" EXACT [EC:3.6.3.11] xref: EC:3.6.3.11 xref: GO:0008555 xref: MetaCyc:3.6.3.11-RXN is_a: CCO:F0002586 ! chloride transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0001993 name: potassium-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [EC:3.6.3.12] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (K+-importing)" EXACT [EC:3.6.3.12] synonym: "K(+)-importing ATPase activity" NARROW [EC:3.6.3.12] synonym: "K(+)-transporting ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-importing ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-translocating Kdp-ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-transporting ATPase activity" EXACT [] synonym: "k+-transporting ATPase activity" EXACT [EC:3.6.3.12] synonym: "multi-subunit K+-transport ATPase" NARROW [EC:3.6.3.12] synonym: "potassium ABC transporter" NARROW [] synonym: "potassium transporting ATPase activity" EXACT [] synonym: "potassium-importing ATPase activity" NARROW [EC:3.6.3.12] synonym: "potassium-uptake-ATPase activity" EXACT [] xref: EC:3.6.3.12 xref: GO:0008556 xref: GO:0015618 xref: MetaCyc:3.6.3.12-RXN is_a: CCO:F0002560 ! potassium ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0001994 name: guanine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [EC:3.6.3.37] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (guanine-importing)" EXACT [EC:3.6.3.37] synonym: "guanine ABC transporter" NARROW [] xref: EC:3.6.3.37 xref: GO:0008558 xref: MetaCyc:3.6.3.37-RXN is_a: CCO:F0002679 ! guanine transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0001995 name: xenobiotic-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (steroid-exporting)" EXACT [EC:3.6.3.44] synonym: "ATP phosphohydrolase (xenobiotic-exporting)" EXACT [EC:3.6.3.44] synonym: "MDR protein" RELATED [EC:3.6.3.44] synonym: "multidrug resistance exporter" RELATED [] synonym: "multidrug-resistance protein" RELATED [] synonym: "P-glycoprotein" RELATED [] synonym: "PDR protein" RELATED [EC:3.6.3.44] synonym: "pleiotropic-drug-resistance protein" RELATED [EC:3.6.3.44] synonym: "steroid ABC transporter" NARROW [] synonym: "steroid-transporting ATPase activity" EXACT [] synonym: "xenobiotic ABC transporter" NARROW [] xref: EC:3.6.3.44 xref: GO:0005226 xref: GO:0008559 xref: GO:0008560 xref: MetaCyc:3.6.3.44-RXN is_a: CCO:F0002707 ! multidrug transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances is_a: CCO:F0005740 ! xenobiotic transporter activity [Term] id: CCO:F0001996 name: protein-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the concomitant secretion of proteins." [EC:3.6.3.50] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (protein-secreting)" EXACT [EC:3.6.3.50] synonym: "protein-secreting ATPase activity" EXACT [] xref: EC:3.6.3.50 xref: GO:0008564 xref: MetaCyc:3.6.3.50-RXN is_a: CCO:F0002869 ! protein-transmembrane transporting ATPase activity [Term] id: CCO:F0001997 name: protein transporter activity namespace: molecular_function def: "Enables the directed movement of proteins into, out of, within or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_goa subset: gosubset_prok synonym: "enzyme transporter activity" NARROW [] synonym: "holin" RELATED [] synonym: "protein carrier activity" EXACT [] synonym: "secretin (sensu Bacteria)" RELATED [] xref: GO:0008565 xref: GO:0015463 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0001998 name: mitochondrial protein-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51] comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'. Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (mitochondrial protein-importing) activity" EXACT [EC:3.6.3.51] xref: EC:3.6.3.51 xref: GO:0008566 xref: MetaCyc:3.6.3.51-RXN is_a: CCO:F0002869 ! protein-transmembrane transporting ATPase activity [Term] id: CCO:F0001999 name: microtubule-severing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] comment: See also the cellular component term 'katanin complex ; GO:0008352'. Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [EC:3.6.4.3] synonym: "katanin activity" NARROW [EC:3.6.4.3] xref: EC:3.6.4.3 xref: GO:0008568 xref: MetaCyc:3.6.4.3-RXN is_a: CCO:F0005696 ! ATPase activity, coupled [Term] id: CCO:F0002000 name: minus-end-directed microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.5, GOC:mah] synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [EC:3.6.4.5] synonym: "minus-end-directed kinesin ATPase activity" BROAD [] xref: EC:3.6.4.5 xref: GO:0008569 xref: MetaCyc:3.6.4.5-RXN is_a: CCO:F0000322 ! microtubule motor activity [Term] id: CCO:F0002001 name: plus-end-directed microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.4] synonym: "kinesin activity" RELATED [EC:3.6.4.4] synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [EC:3.6.4.4] synonym: "plus-end-directed kinesin ATPase activity" BROAD [] xref: EC:3.6.4.4 xref: GO:0008574 xref: MetaCyc:3.6.4.4-RXN is_a: CCO:F0000322 ! microtubule motor activity [Term] id: CCO:F0002002 name: JUN kinase phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah] xref: EC:3.1.3.- xref: GO:0008579 is_a: CCO:F0001741 ! protein tyrosine/serine/threonine phosphatase activity [Term] id: CCO:F0002003 name: ubiquitin-specific protease 5 activity namespace: molecular_function def: "Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001] synonym: "ubiquitin isopeptidase T activity" EXACT [] xref: GO:0008581 is_a: CCO:F0000675 ! ubiquitin thiolesterase activity [Term] id: CCO:F0002004 name: calcium-dependent protein serine/threonine phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW [] xref: GO:0008597 xref: Reactome:25079 is_a: CCO:F0004205 ! protein phosphatase regulator activity [Term] id: CCO:F0002005 name: protein phosphatase type 1 regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 1." [GOC:ai] synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW [] xref: GO:0008599 is_a: CCO:F0004205 ! protein phosphatase regulator activity [Term] id: CCO:F0002006 name: protein phosphatase type 2A regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai] synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW [] xref: GO:0008601 is_a: CCO:F0004205 ! protein phosphatase regulator activity [Term] id: CCO:F0002007 name: cAMP-dependent protein kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] subset: gosubset_prok synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT [] synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW [] synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT [] xref: GO:0008603 is_a: CCO:F0004204 ! protein kinase regulator activity [Term] id: CCO:F0002008 name: protein kinase CK2 regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai] synonym: "casein kinase II, regulator" EXACT [] synonym: "protein kinase CK2, intrinsic regulator activity" NARROW [] xref: GO:0008605 is_a: CCO:F0004204 ! protein kinase regulator activity [Term] id: CCO:F0002009 name: phosphorylase kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW [] xref: EC:2.7.1.- xref: GO:0008607 is_a: CCO:F0004204 ! protein kinase regulator activity [Term] id: CCO:F0002010 name: alkylglycerone-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26] subset: gosubset_prok synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" EXACT [EC:2.5.1.26] synonym: "alkyl DHAP synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26] synonym: "alkyl-DHAP synthase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetone phosphate synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetonephosphate synthase activity" EXACT [EC:2.5.1.26] synonym: "DHAP-AT" RELATED [EC:2.5.1.26] synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.26] xref: EC:2.5.1.26 xref: GO:0008609 xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0002011 name: diuretic hormone activity namespace: molecular_function xref: GO:0008613 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0002013 name: small protein activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "ubiquitin-like activating enzyme activity" NARROW [] xref: GO:0008641 xref: GO:0008642 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0002014 name: rRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008649 is_a: CCO:F0001760 ! RNA methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0002015 name: rRNA (uridine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 2'-O atom of a uridine residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0008650 is_a: CCO:F0003158 ! rRNA (uridine) methyltransferase activity [Term] id: CCO:F0002016 name: caspase activator activity namespace: molecular_function def: "Increases the rate of proteolysis catalyzed by a caspase." [GOC:mah] xref: GO:0008656 is_a: CCO:F0003186 ! apoptotic protease activator activity is_a: CCO:F0005788 ! caspase regulator activity [Term] id: CCO:F0002017 name: DNA gyrase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of DNA gyrase." [GOC:mah] xref: GO:0008657 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0002018 name: penicillin binding namespace: molecular_function def: "Interacting selectively with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] subset: gosubset_prok xref: GO:0008658 is_a: CCO:F0001746 ! drug binding [Term] id: CCO:F0002020 name: 1-aminocyclopropane-1-carboxylate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3." [EC:3.5.99.7] comment: Note that this function was formerly EC:4.1.99.4. subset: gosubset_prok synonym: "1-aminocyclopropane carboxylic acid deaminase activity" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" EXACT [EC:3.5.99.7] synonym: "ACC deaminase activity" EXACT [EC:3.5.99.7] xref: EC:3.5.99.7 xref: GO:0008660 xref: GO:0018806 xref: MetaCyc:4.1.99.4-RXN xref: UM-BBD_enzymeID:e0274 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0002021 name: 1-deoxy-D-xylulose-5-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2." [EC:2.2.1.7] subset: gosubset_prok synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [] synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT [] synonym: "DOXP synthase activity" EXACT [] synonym: "DXP-synthase activity" EXACT [] synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.7] xref: EC:2.2.1.7 xref: GO:0008661 xref: MetaCyc:DXS-RXN is_a: CCO:F0003320 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: CCO:F0002022 name: 1-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56] subset: gosubset_prok synonym: "1-phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.56] synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.56] synonym: "D-fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose 1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56] xref: EC:2.7.1.56 xref: GO:0008662 xref: MetaCyc:1PFRUCTPHOSN-RXN is_a: CCO:F0001906 ! phosphofructokinase activity [Term] id: CCO:F0002023 name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16] subset: gosubset_prok synonym: "2',3 '-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16] synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2':3'-cyclic phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.4.16] synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16] xref: EC:3.1.4.16 xref: GO:0008663 xref: MetaCyc:CYCPHOSDIESTER-RXN is_a: CCO:F0000584 ! cyclic-nucleotide phosphodiesterase activity [Term] id: CCO:F0002024 name: 2'-5'-RNA ligase activity namespace: molecular_function subset: gosubset_prok synonym: "2'-5' RNA ligase activity" EXACT [] xref: EC:6.5.1.- xref: GO:0008664 is_a: CCO:F0001915 ! RNA ligase activity [Term] id: CCO:F0002025 name: 2'-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group from one compound to the 2' position of another." [GOC:jl, GOC:mah] subset: gosubset_prok xref: GO:0008665 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0002026 name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate." [EC:2.3.1.117] subset: gosubset_prok synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinylase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydropicolinate succinylase activity" EXACT [EC:2.3.1.117] xref: EC:2.3.1.117 xref: GO:0008666 xref: MetaCyc:TETHYDPICSUCC-RXN is_a: CCO:F0003324 ! N-succinyltransferase activity [Term] id: CCO:F0002027 name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+." [EC:1.3.1.28] subset: gosubset_prok synonym: "2,3-DHB dehydrogenase activity" EXACT [EC:1.3.1.28] synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.28] xref: EC:1.3.1.28 xref: GO:0008667 xref: MetaCyc:DHBDEHYD-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002029 name: 2,3-dihydroxy-phenylpropionate 1,2-dioxygenase activity namespace: molecular_function xref: EC:1.13.11.- xref: GO:0008669 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0002030 name: 2,4-dienoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34] subset: gosubset_prok synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH) activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH2)" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34] synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34] xref: EC:1.3.1.34 xref: GO:0008670 xref: MetaCyc:DIENOYLCOAREDUCT-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002031 name: 2-dehydro-3-deoxygalactonokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate." [EC:2.7.1.58] subset: gosubset_prok synonym: "2-keto-3-deoxy-galactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-oxo-3-deoxygalactonate kinase activity" EXACT [EC:2.7.1.58] synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" EXACT [EC:2.7.1.58] xref: EC:2.7.1.58 xref: GO:0008671 xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0002032 name: 2-dehydro-3-deoxyglucarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20] subset: gosubset_prok synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.20] synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" EXACT [EC:4.1.2.20] synonym: "2-keto-3-deoxyglucarate aldolase activity" EXACT [EC:4.1.2.20] synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" EXACT [EC:4.1.2.20] xref: EC:4.1.2.20 xref: GO:0008672 xref: MetaCyc:KDGALDOL-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0002033 name: 2-dehydro-3-deoxygluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + beta-L-arabinose 1-phosphate." [EC:2.7.1.45] subset: gosubset_prok synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase activity" EXACT [EC:2.7.1.45] synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.45] synonym: "KDG kinase activity" EXACT [EC:2.7.1.45] synonym: "ketodeoxygluconokinase activity" EXACT [EC:2.7.1.45] xref: EC:2.7.1.45 xref: GO:0008673 xref: MetaCyc:DEOXYGLUCONOKIN-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0002034 name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.21] subset: gosubset_prok synonym: "(KDPGal)aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" EXACT [EC:4.1.2.21] xref: EC:4.1.2.21 xref: GO:0008674 xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0002035 name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14] subset: gosubset_prok synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.14] synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG-aldolase activity" EXACT [EC:4.1.2.14] synonym: "ODPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" EXACT [EC:4.1.2.14] xref: EC:4.1.2.14 xref: GO:0008675 xref: MetaCyc:KDPGALDOL-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0002036 name: 3-deoxy-8-phosphooctulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate." [EC:2.5.1.55] comment: Note that this function was formerly EC:4.1.2.16. subset: gosubset_prok synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-P synthase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDOP synthase activity" EXACT [EC:2.5.1.55] synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.55] xref: EC:2.5.1.55 xref: GO:0008676 xref: MetaCyc:KDO-8PSYNTH-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0002037 name: 2-dehydropantoate 2-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+." [EC:1.1.1.169] subset: gosubset_prok synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "2-oxopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "KPA reductase activity" EXACT [EC:1.1.1.169] xref: EC:1.1.1.169 xref: GO:0008677 xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002038 name: 2-deoxy-D-gluconate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125] subset: gosubset_prok synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.125] synonym: "2-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.125] synonym: "2-keto-3-deoxygluconate oxidoreductase activity" EXACT [EC:1.1.1.125] xref: EC:1.1.1.125 xref: GO:0008678 xref: MetaCyc:KDUD-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002039 name: 2-hydroxy-3-oxopropionate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60] subset: gosubset_prok synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.60] synonym: "tartronate semialdehyde reductase activity" EXACT [EC:1.1.1.60] xref: EC:1.1.1.60 xref: GO:0008679 xref: MetaCyc:TSA-REDUCT-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002040 name: 2-octaprenyl-6-methoxyphenol hydroxylase activity namespace: molecular_function subset: gosubset_prok xref: GO:0008681 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0002041 name: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone." [MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN] xref: GO:0008682 xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0002042 name: 2-oxoglutarate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate = succinate semialdehyde + CO2." [EC:4.1.1.71] subset: gosubset_prok synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" EXACT [EC:4.1.1.71] synonym: "2-oxoglutarate carboxy-lyase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutaric decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "pre-2-oxoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] xref: EC:4.1.1.71 xref: GO:0008683 xref: MetaCyc:2-OXOGLUT-DECARBOX-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0002043 name: 2-oxopent-4-enoate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80] subset: gosubset_prok synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" EXACT [EC:4.2.1.80] synonym: "2-keto-4-pentenoate hydratase activity" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" EXACT [EC:4.2.1.80] synonym: "OEH activity" EXACT [EC:4.2.1.80] xref: EC:4.2.1.80 xref: GO:0008684 xref: GO:0018821 xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN xref: UM-BBD_enzymeID:e0078 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002044 name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP." [EC:4.6.1.12, GOC:mlg] subset: gosubset_prok synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" EXACT [EC:4.6.1.12] synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" EXACT [EC:4.6.1.12] synonym: "MECDP-synthase activity" EXACT [EC:4.6.1.12] synonym: "MECP synthase activity" EXACT [] xref: EC:4.6.1.12 xref: GO:0008685 is_a: CCO:F0003413 ! phosphorus-oxygen lyase activity [Term] id: CCO:F0002045 name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate." [MetaCyc:DIOHBUTANONEPSYN-RXN] subset: gosubset_prok xref: EC:4.1.99.12 xref: GO:0008686 xref: MetaCyc:DIOHBUTANONEPSYN-RXN is_a: CCO:F0003397 ! carbon-carbon lyase activity [Term] id: CCO:F0002046 name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde." [EC:1.13.11.15] subset: gosubset_prok synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.15] synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "homoprotocatechuate 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "HPC dioxygenase activity" EXACT [EC:1.13.11.15] xref: EC:1.13.11.15 xref: GO:0008687 xref: MetaCyc:1.13.11.15-RXN xref: UM-BBD_enzymeID:e0125 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0002047 name: 3-(3-hydroxy-phenyl)propionate hydroxylase activity namespace: molecular_function xref: EC:1.14.13.- xref: GO:0008688 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0002048 name: 3-demethylubiquinone-9 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [EC:2.1.1.64] subset: gosubset_prok synonym: "5-demethylubiquinone-9 methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "OMHMB-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity" EXACT [EC:2.1.1.64] xref: EC:2.1.1.64 xref: GO:0008689 xref: MetaCyc:DHHB-METHYLTRANSFER-RXN is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0002049 name: 3-deoxy-manno-octulosonate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38] subset: gosubset_prok synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-KDO synthetase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT [] synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] xref: EC:2.7.7.38 xref: GO:0008690 xref: MetaCyc:CPM-KDOSYNTH-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002050 name: 3-hydroxybutyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157] subset: gosubset_prok synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "BHBD activity" EXACT [EC:1.1.1.157] synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.157] synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] xref: EC:1.1.1.157 xref: GO:0008691 xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002051 name: 3-hydroxybutyryl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3] subset: gosubset_prok synonym: "3-hydroxyacyl-CoA epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutyryl coenzyme A epimerase activity" EXACT [EC:5.1.2.3] xref: EC:5.1.2.3 xref: GO:0008692 xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN is_a: CCO:F0003419 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: CCO:F0002052 name: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.60] subset: gosubset_prok synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxyacyl-ACP dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoate dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoyl thioester dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoyl thiol ester dehydrase activity" EXACT [EC:4.2.1.60] synonym: "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.60] synonym: "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "FabA" RELATED [EC:4.2.1.60] synonym: "HDDase activity" EXACT [EC:4.2.1.60] xref: EC:4.2.1.60 xref: GO:0008693 xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN is_a: CCO:F0004104 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: CCO:F0002053 name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN] subset: gosubset_prok synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT [] synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "PPHB decarboxylase activity" EXACT [] synonym: "UbiD" RELATED [] synonym: "UbiX" RELATED [] xref: EC:4.1.1.- xref: GO:0008694 xref: GO:0019167 xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0002054 name: 3-phenylpropionate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307] synonym: "3-phenylpropanoate dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" EXACT [EC:1.14.12.19] synonym: "Hca dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19] xref: EC:1.14.12.19 xref: GO:0008695 xref: UM-BBD_enzymeID:e0307 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0002055 name: 4-amino-4-deoxychorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate." [MetaCyc:ADCLY-RXN] comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. subset: gosubset_prok synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" EXACT [EC:4.1.3.38] synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" EXACT [EC:4.1.3.38] synonym: "ADC lyase activity" EXACT [EC:4.1.3.38] synonym: "aminodeoxychorismate lyase activity" EXACT [] synonym: "enzyme X activity" RELATED [EC:4.1.3.38] synonym: "p-aminobenzoate synthetase" RELATED [] synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] synonym: "para-aminobenzoic acid synthase" RELATED [] xref: EC:4.1.3.38 xref: GO:0008696 xref: MetaCyc:ADCLY-RXN is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0002056 name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 4-deoxy-L-threo-5-hexosulose uronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17] subset: gosubset_prok synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.17] synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" EXACT [EC:5.3.1.17] synonym: "5-keto-4-deoxyuronate isomerase activity" EXACT [EC:5.3.1.17] xref: EC:5.3.1.17 xref: GO:0008697 xref: MetaCyc:5.3.1.17-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0002057 name: 4-hydroxy-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.16] subset: gosubset_prok synonym: "2-keto-4-hydroxybutyrate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" EXACT [EC:4.1.3.16] synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "KHG-aldolase activity" EXACT [EC:4.1.3.16] xref: EC:4.1.3.16 xref: GO:0008700 xref: MetaCyc:4OH2OXOGLUTARALDOL-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0002058 name: 4-hydroxy-2-oxovalerate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = pyruvate + acetaldehyde." [EC:4.1.3.39] synonym: "4-hydroxy-2-ketovalerate aldolase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "DmpG" RELATED [EC:4.1.3.39] synonym: "HOA" RELATED [EC:4.1.3.39] xref: EC:4.1.3.39 xref: GO:0008701 xref: GO:0018804 is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0002059 name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+." [EC:1.1.1.193] subset: gosubset_prok synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT [] synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" EXACT [EC:1.1.1.193] synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" EXACT [EC:1.1.1.193] xref: EC:1.1.1.193 xref: GO:0008703 xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002060 name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10] subset: gosubset_prok synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED [] synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT [] synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" EXACT [EC:5.3.3.10] synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" EXACT [EC:5.3.3.10] synonym: "CHM isomerase activity" EXACT [EC:5.3.3.10] synonym: "HHDD isomerase activity" EXACT [] synonym: "hpaG-1" RELATED [] synonym: "hpaG1" RELATED [] xref: EC:5.3.3.10 xref: GO:0008704 xref: GO:0018843 xref: MetaCyc:5.3.3.10-RXN xref: UM-BBD_enzymeID:e0135 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0002061 name: methionine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine." [EC:2.1.1.13] subset: gosubset_prok synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT [] synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "cobalamin-dependent methionine synthase activity" EXACT [EC:2.1.1.13] synonym: "MetH" RELATED [EC:2.1.1.13] synonym: "methionine synthase (cobalamin-dependent) activity" EXACT [EC:2.1.1.13] synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamic methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] xref: EC:2.1.1.13 xref: GO:0008705 xref: MetaCyc:HOMOCYSMETB12-RXN xref: Reactome:25894 is_a: CCO:F0001759 ! S-methyltransferase activity is_a: CCO:F0005620 ! 5-methyltetrahydrofolate-dependent methyltransferase activity [Term] id: CCO:F0002062 name: 6-phospho-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86] subset: gosubset_prok synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" EXACT [EC:3.2.1.86] synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86] synonym: "phospho-beta-glucosidase activity" EXACT [EC:3.2.1.86] synonym: "phosphocellobiase activity" EXACT [EC:3.2.1.86] xref: EC:3.2.1.86 xref: GO:0008706 xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN is_a: CCO:F0001889 ! beta-glucosidase activity [Term] id: CCO:F0002063 name: 4-phytase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26] subset: gosubset_prok synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26] synonym: "6-phytase activity" EXACT [] synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.26] synonym: "phytase activity" BROAD [EC:3.1.3.26] synonym: "phytate 6-phosphatase activity" EXACT [EC:3.1.3.26] xref: EC:3.1.3.26 xref: GO:0008707 xref: MetaCyc:6-PHYT-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0002064 name: 7-alpha-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD+ = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH + H+." [EC:1.1.1.159] subset: gosubset_prok synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159] synonym: "7alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" EXACT [EC:1.1.1.159] xref: EC:1.1.1.159 xref: GO:0008709 xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002065 name: 8-amino-7-oxononanoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO2." [EC:2.3.1.47] subset: gosubset_prok synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" EXACT [EC:2.3.1.47] synonym: "7-KAP synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-amino-pelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic synthetase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-ketopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-oxopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "AONS activity" EXACT [EC:2.3.1.47] xref: EC:2.3.1.47 xref: GO:0008710 xref: MetaCyc:7KAPSYN-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0002066 name: ADP-glyceromanno-heptose 6-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20] subset: gosubset_prok synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] synonym: "ADPglyceromanno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] xref: EC:5.1.3.20 xref: GO:0008712 xref: MetaCyc:5.1.3.20-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0002067 name: ADP-heptose-lipopolysaccharide heptosyltransferase activity namespace: molecular_function subset: gosubset_prok xref: GO:0008713 is_a: CCO:F0002256 ! lipopolysaccharide heptosyltransferase activity [Term] id: CCO:F0002068 name: AMP nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H2O = adenine + D-ribose 5-phosphate." [EC:3.2.2.4] subset: gosubset_prok synonym: "adenosine monophosphate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "adenylate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "AMP phosphoribohydrolase activity" EXACT [EC:3.2.2.4] xref: EC:3.2.2.4 xref: GO:0008714 xref: MetaCyc:AMP-NUCLEOSID-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0002069 name: CDP-diacylglycerol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + H2O = CMP + phosphatidate." [EC:3.6.1.26] subset: gosubset_prok synonym: "CDP diacylglycerol hydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT [] synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" EXACT [EC:3.6.1.26] xref: EC:3.6.1.26 xref: GO:0008715 xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0002070 name: D-alanine-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine." [EC:6.3.2.4] subset: gosubset_prok synonym: "alanine:alanine ligase (ADP-forming) activity" EXACT [EC:6.3.2.4] synonym: "alanylalanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-Ala-D-Ala synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanine:D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.4] synonym: "D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanylalanine synthetase activity" EXACT [EC:6.3.2.4] xref: EC:6.3.2.4 xref: GO:0008716 xref: MetaCyc:DALADALALIG-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0002071 name: D-alanyl-D-alanine endopeptidase activity namespace: molecular_function subset: gosubset_prok synonym: "penicillin-binding protein 7" NARROW [] synonym: "penicillin-binding protein 8" NARROW [] xref: EC:3.4.99.- xref: GO:0008717 is_a: CCO:F0000644 ! endopeptidase activity [Term] id: CCO:F0002072 name: D-amino-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [EC:1.4.99.1] subset: gosubset_prok synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] xref: EC:1.4.99.1 xref: GO:0008718 xref: MetaCyc:DAADEHYDROG-RXN is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0002073 name: dihydroneopterin triphosphate 2'-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN] subset: gosubset_prok synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT [] xref: EC:5.-.-.- xref: GO:0008719 xref: MetaCyc:H2NTPEPIM-RXN is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0002074 name: D-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.28] subset: gosubset_prok synonym: "D-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.28] synonym: "D-lactic dehydrogenase activity" EXACT [EC:1.1.1.28] xref: EC:1.1.1.28 xref: GO:0008720 xref: MetaCyc:DLACTDEHYDROGNAD-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002075 name: D-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18] comment: Note that this function was formerly EC:4.3.1.14. subset: gosubset_prok synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18] synonym: "D-hydroxyaminoacid dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.18] synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18] xref: EC:4.3.1.18 xref: GO:0008721 xref: MetaCyc:DSERDEAM-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0002076 name: DNA-3-methyladenine glycosylase I activity namespace: molecular_function def: "Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] subset: gosubset_prok synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20] synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20] synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20] synonym: "DNA-3-methyladenine glycosidase I activity" EXACT [EC:3.2.2.20] xref: EC:3.2.2.20 xref: GO:0008725 xref: MetaCyc:3.2.2.20-RXN is_a: CCO:F0000410 ! alkylbase DNA N-glycosylase activity [Term] id: CCO:F0002077 name: alkanesulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + SO3(2-) (sulfite) + H2O + FMN." [MetaCyc:RXN0-280] subset: gosubset_prok synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" EXACT [EC:1.14.14.5] synonym: "alkanesulphonate monooxygenase activity" EXACT [] synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT [] synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "SsuD" RELATED [EC:1.14.14.5] synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5] xref: EC:1.14.14.5 xref: GO:0008726 xref: MetaCyc:RXN0-280 is_a: CCO:F0003295 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0002078 name: GDP-mannose mannosyl hydrolase activity namespace: molecular_function xref: GO:0008727 is_a: CCO:F0003018 ! mannosidase activity [Term] id: CCO:F0002079 name: GTP diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5] subset: gosubset_prok synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5] synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5] synonym: "ATP-GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "ATP:GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "GPSI" RELATED [EC:2.7.6.5] synonym: "GPSII" RELATED [EC:2.7.6.5] synonym: "GTP pyrophosphokinase activity" EXACT [] synonym: "guanosine 3',5'-polyphosphate synthase activity" EXACT [EC:2.7.6.5] synonym: "guanosine 5',3'-polyphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "guanosine pentaphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "ppGpp synthetase I activity" EXACT [EC:2.7.6.5] synonym: "stringent factor activity" RELATED [EC:2.7.6.5] xref: EC:2.7.6.5 xref: GO:0008728 xref: MetaCyc:GTPPYPHOSKIN-RXN is_a: CCO:F0003350 ! diphosphotransferase activity is_a: CCO:F0004128 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: CCO:F0002080 name: L(+)-tartrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R,R)-tartrate = oxaloacetate + H2O." [EC:4.2.1.32] subset: gosubset_prok synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.32] synonym: "(R,R)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.32] synonym: "L-(+)-tartaric acid dehydratase activity" EXACT [EC:4.2.1.32] synonym: "L-tartrate dehydratase activity" EXACT [EC:4.2.1.32] synonym: "tartaric acid dehydrase activity" EXACT [EC:4.2.1.32] synonym: "tartrate dehydratase activity" EXACT [EC:4.2.1.32] xref: EC:4.2.1.32 xref: GO:0008730 xref: MetaCyc:LTARTDEHYDRA-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002081 name: L-allo-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [MetaCyc:LTAA-RXN, PMID:9228760] subset: gosubset_prok synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT [] synonym: "LtaA" RELATED [] xref: EC:4.1.2.- xref: GO:0008732 xref: MetaCyc:LTAA-RXN is_a: CCO:F0001151 ! threonine aldolase activity [Term] id: CCO:F0002082 name: L-arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4] subset: gosubset_prok synonym: "L-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.4] synonym: "L-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.4] xref: EC:5.3.1.4 xref: GO:0008733 xref: MetaCyc:ARABISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0002083 name: L-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.16] subset: gosubset_prok synonym: "L-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.16] xref: EC:1.4.3.16 xref: GO:0008734 xref: MetaCyc:L-ASPARTATE-OXIDASE-RXN is_a: CCO:F0003017 ! aspartate oxidase activity [Term] id: CCO:F0002084 name: carnitine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-carnitine = 4-(trimethylammonio)but-2-enoate + H2O." [EC:4.2.1.89] subset: gosubset_prok synonym: "L-carnitine dehydratase activity" EXACT [] synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED [EC:4.2.1.89] synonym: "L-carnitine hydro-lyase activity" EXACT [EC:4.2.1.89] xref: EC:4.2.1.89 xref: GO:0008735 xref: MetaCyc:CARNDEHYDRA-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002085 name: L-fucose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-fucose = L-fuculose." [EC:5.3.1.25] subset: gosubset_prok synonym: "L-fucose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.25] synonym: "L-fucose ketol-isomerase activity" EXACT [EC:5.3.1.25] xref: EC:5.3.1.25 xref: GO:0008736 xref: MetaCyc:FUCISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0002086 name: L-fuculokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-fuculose = ADP + L-fuculose 1-phosphate." [EC:2.7.1.51] subset: gosubset_prok synonym: "ATP:L-fuculose 1-phosphotransferase activity" EXACT [EC:2.7.1.51] synonym: "L-fuculokinase (phosphorylating)" EXACT [EC:2.7.1.51] synonym: "L-fuculose kinase activity" EXACT [EC:2.7.1.51] xref: EC:2.7.1.51 xref: GO:0008737 xref: MetaCyc:FUCULOKIN-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0002087 name: L-fuculose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.17] subset: gosubset_prok synonym: "fuculose aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose 1-phosphate aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.17] xref: EC:4.1.2.17 xref: GO:0008738 xref: MetaCyc:FUCPALDOL-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0002088 name: L-rhamnose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [EC:5.3.1.14] subset: gosubset_prok synonym: "L-rhamnose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.14] synonym: "L-rhamnose ketol-isomerase activity" EXACT [EC:5.3.1.14] synonym: "rhamnose isomerase activity" EXACT [EC:5.3.1.14] xref: EC:5.3.1.14 xref: GO:0008740 xref: MetaCyc:RHAMNISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0002089 name: ribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16] subset: gosubset_prok synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.16] synonym: "L-ribulokinase activity" EXACT [] synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16] xref: EC:2.7.1.16 xref: GO:0008741 xref: MetaCyc:RIBULOKIN-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0002090 name: L-ribulose-phosphate 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylose 5-phosphate." [EC:5.1.3.4] subset: gosubset_prok synonym: "AraD" RELATED [EC:5.1.3.4] synonym: "L-ribulose 5-phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4] synonym: "L-Ru5P" RELATED [EC:5.1.3.4] synonym: "L-ru5P activity" EXACT [EC:5.1.3.4] synonym: "phosphoribulose isomerase activity" EXACT [EC:5.1.3.4] synonym: "ribulose phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] xref: EC:5.1.3.4 xref: GO:0008742 xref: MetaCyc:RIBULPEPIM-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0002091 name: L-threonine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+." [EC:1.1.1.103] subset: gosubset_prok synonym: "L-threonine dehydrogenase activity" EXACT [EC:1.1.1.103] synonym: "L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.103] synonym: "threonine 3-dehydrogenase activity" BROAD [] synonym: "threonine dehydrogenase activity" EXACT [EC:1.1.1.103] xref: EC:1.1.1.103 xref: GO:0008743 xref: MetaCyc:THREODEHYD-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002092 name: L-xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53] subset: gosubset_prok synonym: "ATP:L-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.53] synonym: "L-xylulokinase (phosphorylating)" EXACT [EC:2.7.1.53] synonym: "L-xylulose kinase activity" EXACT [EC:2.7.1.53] xref: EC:2.7.1.53 xref: GO:0008744 xref: MetaCyc:LYXK-RXN is_a: CCO:F0001212 ! xylulokinase activity [Term] id: CCO:F0002093 name: N-acetylmuramoyl-L-alanine amidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28] subset: gosubset_prok synonym: "acetylmuramoyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "murein hydrolase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramic acid L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramylalanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "peptidoglycan amidohydrolase activity" EXACT [EC:3.5.1.28] xref: EC:3.5.1.28 xref: GO:0008745 xref: MetaCyc:3.5.1.28-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0002094 name: NAD(P) transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.1, EC:1.6.1.2] subset: gosubset_prok synonym: "energy-linked transhydrogenase" EXACT [EC:1.6.1.1, EC:1.6.1.2] synonym: "H+-thase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1, EC:1.6.1.2] xref: EC:1.6.1.- xref: GO:0008746 is_a: CCO:F0003250 ! oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor [Term] id: CCO:F0002095 name: N-acetylneuraminate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3] subset: gosubset_prok synonym: "acetylneuraminate lyase activity" EXACT [EC:4.1.3.3] synonym: "acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic lyase activity" EXACT [EC:4.1.3.3] synonym: "NALase activity" EXACT [EC:4.1.3.3] synonym: "NANA lyase activity" EXACT [EC:4.1.3.3] synonym: "neuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "NPL" RELATED [EC:4.1.3.3] synonym: "sialate lyase activity" EXACT [EC:4.1.3.3] synonym: "sialic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "sialic aldolase activity" EXACT [EC:4.1.3.3] xref: EC:4.1.3.3 xref: GO:0008747 xref: MetaCyc:ACNEULY-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0002096 name: N-ethylmaleimide reductase activity namespace: molecular_function subset: gosubset_prok xref: GO:0008748 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0002097 name: NAD(P)+ transhydrogenase (AB-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+." [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf?sessid] subset: gosubset_prok synonym: "NAD(P) transhydrogenase (AB-specific) activity" EXACT [EC:1.6.1.2] synonym: "NADPH:NAD+ oxidoreductase (AB-specific)" EXACT [EC:1.6.1.2] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.2] synonym: "transhydrogenase activity" BROAD [EC:1.6.1.2] xref: EC:1.6.1.2 xref: GO:0008750 xref: MetaCyc:1.6.1.2-RXN is_a: CCO:F0002094 ! NAD(P) transhydrogenase activity [Term] id: CCO:F0002098 name: FMN reductase activity namespace: molecular_function def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+." [EC:1.5.1.29] subset: gosubset_prok synonym: "flavin mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "flavine mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "FMNH2:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT [] synonym: "NAD(P)H(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-dependent FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2 dehydrogenase (FMN)" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:flavin oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "SsuE" RELATED [EC:1.5.1.29] xref: EC:1.5.1.29 xref: GO:0008752 xref: MetaCyc:FMNREDUCT-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002099 name: NADPH dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [EC:1.6.99.6] subset: gosubset_prok synonym: "NADPH oxidase" BROAD [EC:1.6.99.6] synonym: "NADPH:(quinone-acceptor) oxidoreductase" EXACT [EC:1.6.99.6] synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" EXACT [EC:1.6.99.6] xref: EC:1.6.99.6 xref: GO:0008753 xref: MetaCyc:NADPH-DEHYDROGENASE-(QUINONE)-RXN is_a: CCO:F0000452 ! NADPH dehydrogenase activity [Term] id: CCO:F0002100 name: O antigen ligase activity namespace: molecular_function xref: GO:0008754 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0002101 name: O antigen polymerase activity namespace: molecular_function def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra and penta saccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "O-antigen polymerase activity" EXACT [] xref: EC:2.4.1.- xref: GO:0008755 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0002102 name: o-succinylbenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA." [EC:6.2.1.26] subset: gosubset_prok synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-CoA synthetase activity" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.26] synonym: "OSB-CoA synthetase activity" EXACT [EC:6.2.1.26] synonym: "osb-CoA synthetase activity" EXACT [EC:6.2.1.26] xref: EC:6.2.1.26 xref: GO:0008756 xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0002103 name: S-adenosylmethionine-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] subset: gosubset_prok synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT [] synonym: "SAM-dependent methyltransferase activity" EXACT [] xref: GO:0008757 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0002104 name: UDP-2,3-diacylglucosamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770] subset: gosubset_prok xref: EC:3.6.1.- xref: GO:0008758 xref: MetaCyc:LIPIDXSYNTHESIS-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0002105 name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity namespace: molecular_function def: "Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271] subset: gosubset_prok xref: EC:3.5.1.- xref: GO:0008759 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0002106 name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7] subset: gosubset_prok synonym: "enoylpyruvate transferase activity" EXACT [EC:2.5.1.7] synonym: "MurA transferase activity" NARROW [EC:2.5.1.7] synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-UDP-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" EXACT [EC:2.5.1.7] xref: EC:2.5.1.7 xref: GO:0008760 xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0002107 name: UDP-N-acetylglucosamine 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14] subset: gosubset_prok synonym: "UDP-GlcNAc-2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] xref: EC:5.1.3.14 xref: GO:0008761 xref: MetaCyc:UDPGLCNACEPIM-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0002108 name: UDP-N-acetylmuramate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] subset: gosubset_prok synonym: "MurB reductase" RELATED [EC:1.1.1.158] synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.158] synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" EXACT [EC:1.1.1.158] xref: EC:1.1.1.158 xref: GO:0008762 xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002109 name: UDP-N-acetylmuramate-L-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8] subset: gosubset_prok synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8] synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8] synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-MurNAc:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDPMurNAc-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] xref: EC:6.3.2.8 xref: GO:0008763 xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0002110 name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [EC:6.3.2.9] subset: gosubset_prok synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9] synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9] synonym: "MurD synthetase activity" EXACT [EC:6.3.2.9] synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] xref: EC:6.3.2.9 xref: GO:0008764 xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0002111 name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13] subset: gosubset_prok synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" EXACT [EC:6.3.2.13] xref: EC:6.3.2.13 xref: GO:0008765 xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0002112 name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [EC:6.3.2.15] comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10). subset: gosubset_prok xref: EC:6.3.2.- xref: GO:0008766 xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0002113 name: UDP-galactopyranose mutase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9] subset: gosubset_prok synonym: "UDP-D-galactopyranose furanomutase activity" EXACT [EC:5.4.99.9] synonym: "UDPgalactopyranose mutase activity" EXACT [EC:5.4.99.9] xref: EC:5.4.99.9 xref: GO:0008767 xref: MetaCyc:GALPMUT-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0002114 name: UDP-sugar diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45] subset: gosubset_prok synonym: "nucleosidediphosphate-sugar diphosphatase activity" EXACT [EC:3.6.1.45] synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar hydrolase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.45] xref: EC:3.6.1.45 xref: GO:0008768 xref: MetaCyc:UDPSUGARHYDRO-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0002115 name: X-His dipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3] subset: gosubset_prok synonym: "aminoacyl-histidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "aminoacylhistidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "carnosinase activity" RELATED [EC:3.4.13.3] synonym: "dipeptidase M" RELATED [EC:3.4.13.3] synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3] synonym: "Xaa-His dipeptidase activity" EXACT [] xref: EC:3.4.13.3 xref: GO:0008769 xref: MetaCyc:3.4.13.3-RXN is_a: CCO:F0001785 ! metalloexopeptidase activity is_a: CCO:F0003375 ! dipeptidase activity [Term] id: CCO:F0002120 name: acetaldehyde dehydrogenase (acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10] subset: gosubset_prok synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.10] synonym: "acylating acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.10] synonym: "ADA" RELATED [EC:1.2.1.10] synonym: "aldehyde dehydrogenase (acylating) activity" EXACT [EC:1.2.1.10] synonym: "DmpF" RELATED [EC:1.2.1.10] xref: EC:1.2.1.10 xref: GO:0008774 xref: MetaCyc:ACETALD-DEHYDROG-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002121 name: acetate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8] subset: gosubset_prok synonym: "acetate coenzyme A-transferase activity" EXACT [EC:2.8.3.8] synonym: "acetyl-CoA:acetoacetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "acyl-CoA:acetate CoA-transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl coenzyme A transferase activity" EXACT [EC:2.8.3.8] synonym: "succinyl-CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] xref: EC:2.8.3.8 xref: GO:0008775 xref: MetaCyc:ACECOATRANS-RXN xref: UM-BBD_enzymeID:e0012 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0002122 name: acetate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1] subset: gosubset_prok synonym: "acetate kinase (phosphorylating) activity" EXACT [EC:2.7.2.1] synonym: "acetic kinase activity" EXACT [EC:2.7.2.1] synonym: "acetokinase activity" EXACT [EC:2.7.2.1] synonym: "AckA" RELATED [EC:2.7.2.1] synonym: "AK activity" EXACT [EC:2.7.2.1] synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1] xref: EC:2.7.2.1 xref: GO:0008776 xref: MetaCyc:ACETATEKIN-RXN xref: UM-BBD_enzymeID:e0031 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0002123 name: acetylornithine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N2-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] xref: EC:3.5.1.16 xref: GO:0008777 xref: MetaCyc:ACETYLORNDEACET-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0002124 name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40] synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXACT [EC:2.3.1.40] synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40] xref: EC:2.3.1.40 xref: GO:0008779 xref: MetaCyc:ACYLGPEACYLTRANS-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0002125 name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129] subset: gosubset_prok synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" EXACT [EC:2.3.1.129] synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129] synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] xref: EC:2.3.1.129 xref: GO:0008780 xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0002126 name: N-acylneuraminate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43] subset: gosubset_prok synonym: "acetylneuraminate cytidylyltransferase activity" EXACT [EC:2.7.7.43] synonym: "acylneuraminate cytidyltransferase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NANA synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-Neu5Ac synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuNAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate diphosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic synthetase activity" EXACT [EC:2.7.7.43] synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT [] synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5'-monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphoacetylneuraminic synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] xref: EC:2.7.7.43 xref: GO:0008781 xref: MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002127 name: adenosylhomocysteine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9] subset: gosubset_prok synonym: "5'-methyladenosine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "AdoHcy/MTA nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9] synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9] xref: EC:3.2.2.9 xref: GO:0008782 xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0002128 name: agmatinase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + H2O = putrescine + urea." [EC:3.5.3.11] subset: gosubset_prok synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11] synonym: "agmatine ureohydrolase activity" EXACT [EC:3.5.3.11] synonym: "SpeB" RELATED [EC:3.5.3.11] xref: EC:3.5.3.11 xref: GO:0008783 xref: MetaCyc:AGMATIN-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0002129 name: alanine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1] subset: gosubset_prok synonym: "L-alanine racemase activity" EXACT [EC:5.1.1.1] xref: EC:5.1.1.1 xref: GO:0008784 xref: MetaCyc:ALARACECAT-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0002130 name: alkyl hydroperoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [UM-BBD_enzymeID:e0429] subset: gosubset_prok xref: EC:1.6.4.- xref: GO:0008785 xref: UM-BBD_enzymeID:e0429 is_a: CCO:F0003252 ! oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor [Term] id: CCO:F0002131 name: allose 6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [MetaCyc:RXN0-303] xref: EC:5.3.1.- xref: GO:0008786 xref: MetaCyc:RXN0-303 is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0002132 name: allose kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55] subset: gosubset_prok synonym: "allokinase (phosphorylating)" EXACT [EC:2.7.1.55] synonym: "allokinase activity" EXACT [EC:2.7.1.55] synonym: "ATP:D-allose 6-phosphotransferase activity" EXACT [EC:2.7.1.55] synonym: "D-allokinase activity" EXACT [EC:2.7.1.55] synonym: "D-allose-6-kinase activity" EXACT [EC:2.7.1.55] xref: EC:2.7.1.55 xref: GO:0008787 xref: MetaCyc:ALLOSE-KINASE-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0002133 name: alpha,alpha-phosphotrehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93] subset: gosubset_prok synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" EXACT [EC:3.2.1.93] synonym: "phosphotrehalase activity" EXACT [EC:3.2.1.93] synonym: "trehalose-6-phosphate hydrolase activity" EXACT [EC:3.2.1.93] xref: EC:3.2.1.93 xref: GO:0008788 xref: MetaCyc:TRE6PHYDRO-RXN is_a: CCO:F0003022 ! trehalase activity [Term] id: CCO:F0002134 name: altronate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.7] subset: gosubset_prok synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.7] synonym: "D-altronate hydro-lyase activity" EXACT [EC:4.2.1.7] xref: EC:4.2.1.7 xref: GO:0008789 xref: MetaCyc:ALTRODEHYDRAT-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002135 name: arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3] synonym: "D-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3] synonym: "D-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose(L-fucose) isomerase activity" EXACT [EC:5.3.1.3] xref: EC:5.3.1.3 xref: GO:0008790 xref: MetaCyc:DARABISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0002136 name: arginine N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109] subset: gosubset_prok synonym: "AOST activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N(2)-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "AST activity" EXACT [EC:2.3.1.109] synonym: "AstA" RELATED [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] xref: EC:2.3.1.109 xref: GO:0008791 xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN is_a: CCO:F0003324 ! N-succinyltransferase activity [Term] id: CCO:F0002137 name: arginine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine = agmatine + CO2." [EC:4.1.1.19] subset: gosubset_prok synonym: "L-arginine carboxy-lyase (agmatine-forming)" EXACT [EC:4.1.1.19] synonym: "L-arginine carboxy-lyase activity" EXACT [EC:4.1.1.19] synonym: "SpeA" RELATED [EC:4.1.1.19] xref: EC:4.1.1.19 xref: GO:0008792 xref: MetaCyc:ARGDECARBOX-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0002138 name: aromatic-amino-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [EC:2.6.1.57] subset: gosubset_prok synonym: "ArAT" RELATED [EC:2.6.1.57] synonym: "aromatic amino acid aminotransferase activity" EXACT [EC:2.6.1.57] synonym: "aromatic amino acid transferase activity" EXACT [] synonym: "aromatic aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.57] xref: EC:2.6.1.57 xref: GO:0008793 xref: UM-BBD_enzymeID:e0142 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0002139 name: arsenate reductase (glutaredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884] subset: gosubset_prok synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1] xref: EC:1.20.4.1 xref: GO:0008794 xref: MetaCyc:RXN-982 xref: UM-BBD_enzymeID:e0261 is_a: CCO:F0004498 ! arsenate reductase activity is_a: CCO:F0004501 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor [Term] id: CCO:F0002140 name: NAD+ synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5] subset: gosubset_prok synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.5] synonym: "diphosphopyridine nucleotide synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD synthase (AMP-forming)" EXACT [] synonym: "NAD synthase activity" EXACT [] synonym: "NAD synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD(+) synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD+ synthetase activity" EXACT [EC:6.3.1.5] synonym: "nicotinamide adenine dinucleotide synthetase activity" EXACT [EC:6.3.1.5] xref: EC:6.3.1.5 xref: GO:0008749 xref: GO:0008795 xref: GO:0016965 xref: MetaCyc:NAD-SYNTH-NH3-RXN is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0002141 name: bis(5'-nucleosyl)-tetraphosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai] subset: gosubset_prok xref: EC:3.6.1.- xref: GO:0008796 is_a: CCO:F0000937 ! nucleotide diphosphatase activity [Term] id: CCO:F0002142 name: aspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1] subset: gosubset_prok synonym: "aspartase activity" EXACT [EC:4.3.1.1] synonym: "fumaric aminase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase (fumarate-forming)" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.1] xref: EC:4.3.1.1 xref: GO:0008797 xref: MetaCyc:ASPARTASE-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0002143 name: beta-aspartyl-peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5] subset: gosubset_prok synonym: "beta-aspartyl dipeptidase activity" EXACT [EC:3.4.19.5] synonym: "beta-aspartyl peptidase activity" EXACT [EC:3.4.19.5] xref: EC:3.4.19.5 xref: GO:0008798 xref: MetaCyc:3.4.19.5-RXN is_a: CCO:F0001792 ! omega peptidase activity [Term] id: CCO:F0002144 name: beta-lactamase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6] subset: gosubset_prok synonym: "ampicillinase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactam hydrolase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6] synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6] synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6] synonym: "cephalosporin-beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "exopenicillinase activity" EXACT [EC:3.5.2.6] synonym: "neutrapen" RELATED [EC:3.5.2.6] synonym: "penicillin amido-beta-lactamhydrolase activity" EXACT [EC:3.5.2.6] synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "penicillinase I, II" RELATED [EC:3.5.2.6] xref: EC:3.5.2.6 xref: GO:0008800 xref: MetaCyc:BETA-LACTAMASE-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0002145 name: beta-phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6] subset: gosubset_prok synonym: "beta-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.6] xref: EC:5.4.2.6 xref: GO:0008801 xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0002146 name: betaine-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8] subset: gosubset_prok synonym: "BADH activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde dehydrogenase activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde oxidase activity" EXACT [EC:1.2.1.8] synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.8] synonym: "BetB" RELATED [EC:1.2.1.8] xref: EC:1.2.1.8 xref: GO:0008802 xref: MetaCyc:BADH-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002147 name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = 2 NDP." [EC:3.6.1.41, PMID:6317672] subset: gosubset_prok synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "adenosine tetraphosphate phosphodiesterase activity" EXACT [EC:3.6.1.41] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "bis(5'-adenosyl) tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine polyphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW [] synonym: "diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosinetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] xref: EC:3.6.1.41 xref: GO:0008803 xref: MetaCyc:3.6.1.41-RXN is_a: CCO:F0002141 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: CCO:F0002148 name: carbamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2] subset: gosubset_prok synonym: "ATP:carbamate phosphotransferase activity" EXACT [EC:2.7.2.2] synonym: "carbamoyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "carbamyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "CKase activity" EXACT [EC:2.7.2.2] xref: EC:2.7.2.2 xref: GO:0008804 xref: MetaCyc:CARBAMATE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0002149 name: carbon-monoxide oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [EC:1.2.2.4] synonym: "carbon monoxide oxidase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [EC:1.2.2.4] synonym: "carbon monoxide oxygenase activity" EXACT [] synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW [EC:1.2.2.4] synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4] synonym: "cytochrome b561" NARROW [] xref: EC:1.2.2.4 xref: GO:0008805 xref: GO:0018999 xref: GO:0047767 xref: MetaCyc:1.2.2.4-RXN xref: UM-BBD_enzymeID:e0180 is_a: CCO:F0003224 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: CCO:F0002150 name: carboxymethylenebutenolidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45] subset: gosubset_prok synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" EXACT [EC:3.1.1.45] synonym: "carboxymethylene butenolide hydrolase activity" EXACT [EC:3.1.1.45] synonym: "dienelactone hydrolase activity" EXACT [EC:3.1.1.45] synonym: "maleylacetate enol-lactonase activity" EXACT [EC:3.1.1.45] xref: EC:3.1.1.45 xref: GO:0008806 xref: GO:0018735 xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN xref: UM-BBD_enzymeID:e0066 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0002151 name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23] subset: gosubset_prok synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" EXACT [EC:2.7.8.23] synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" EXACT [EC:2.7.8.23] synonym: "CPEP phosphonomutase activity" EXACT [EC:2.7.8.23] xref: EC:2.7.8.23 xref: GO:0008807 xref: MetaCyc:2.7.8.23-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0002152 name: cardiolipin synthase activity namespace: molecular_function def: "Phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol." [GOC:jl] subset: gosubset_prok synonym: "cardiolipin synthetase activity" BROAD [] synonym: "diphosphatidylglycerol synthase activity" EXACT [] xref: EC:2.7.8.- xref: GO:0008808 xref: MetaCyc:CARDIOLIPSYN-RXN is_a: CCO:F0004483 ! phosphatidyltransferase activity [Term] id: CCO:F0002153 name: carnitine racemase activity namespace: molecular_function def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN] xref: EC:5.1.-.- xref: GO:0008809 xref: MetaCyc:CARNRACE-RXN is_a: CCO:F0003419 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: CCO:F0002154 name: cellulase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4] subset: gosubset_prok synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.4] synonym: "9.5 cellulase activity" EXACT [EC:3.2.1.4] synonym: "alkali cellulase activity" EXACT [EC:3.2.1.4] synonym: "avicelase activity" BROAD [EC:3.2.1.4] synonym: "beta-1,4-endoglucan hydrolase activity" EXACT [EC:3.2.1.4] synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4] synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4] synonym: "celluase A" RELATED [EC:3.2.1.4] synonym: "celludextrinase activity" EXACT [EC:3.2.1.4] synonym: "cellulase A 3" RELATED [EC:3.2.1.4] synonym: "cellulosin AP" RELATED [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.4] synonym: "endo-1,4-beta-glucanase activity" EXACT [EC:3.2.1.4] synonym: "endoglucanase activity" EXACT [EC:3.2.1.4] synonym: "endoglucanase D" RELATED [EC:3.2.1.4] synonym: "pancellase SS" RELATED [EC:3.2.1.4] xref: EC:3.2.1.4 xref: GO:0008810 xref: MetaCyc:3.2.1.4-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0002155 name: chloramphenicol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate." [EC:2.3.1.28] subset: gosubset_prok synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "CAT I" RELATED [EC:2.3.1.28] synonym: "CAT II" RELATED [EC:2.3.1.28] synonym: "CAT III" RELATED [EC:2.3.1.28] synonym: "chloramphenicol acetylase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol transacetylase activity" EXACT [EC:2.3.1.28] xref: EC:2.3.1.28 xref: GO:0008811 xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0002156 name: choline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: choline + acceptor = betaine aldehyde + reduced acceptor." [EC:1.1.99.1] subset: gosubset_prok synonym: "choline oxidase activity" BROAD [EC:1.1.99.1] synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1] synonym: "choline:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.1] xref: EC:1.1.99.1 xref: GO:0008812 xref: MetaCyc:CHD-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0002157 name: chorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, IMG:00552, MetaCyc:CHORPYRLY-RXN] subset: gosubset_prok synonym: "4-hydroxybenzoate synthetase activity" EXACT [] synonym: "chorismate pyruvate lyase activity" EXACT [] synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" EXACT [EC:4.1.3.40] synonym: "CL" RELATED [EC:4.1.3.40] synonym: "CPL" RELATED [EC:4.1.3.40] synonym: "UbiC" RELATED [EC:4.1.3.40] xref: EC:4.1.3.40 xref: GO:0008813 xref: MetaCyc:CHORPYRLY-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0002158 name: citrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10] subset: gosubset_prok synonym: "acetyl-CoA:citrate CoA-transferase activity" EXACT [EC:2.8.3.10] xref: EC:2.8.3.10 xref: GO:0008814 xref: MetaCyc:CITTRANS-RXN is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0002159 name: citrate (pro-3S)-lyase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [EC:4.1.3.6] subset: gosubset_prok synonym: "citrase activity" EXACT [EC:4.1.3.6] synonym: "citratase activity" EXACT [EC:4.1.3.6] synonym: "citrate aldolase activity" EXACT [EC:4.1.3.6] synonym: "citrate lyase activity" EXACT [] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6] synonym: "citrate oxaloacetate-lyase activity" EXACT [EC:4.1.3.6] synonym: "citric aldolase activity" EXACT [EC:4.1.3.6] synonym: "citridesmolase activity" EXACT [EC:4.1.3.6] synonym: "citritase activity" EXACT [EC:4.1.3.6] xref: EC:4.1.3.6 xref: GO:0008815 xref: MetaCyc:CITLY-RXN xref: Reactome:26375 is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0002160 name: citryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34] subset: gosubset_prok synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.34] synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" EXACT [EC:4.1.3.34] xref: EC:4.1.3.34 xref: GO:0008816 xref: MetaCyc:CITRYLY-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0002161 name: cob(I)yrinic acid a,c-diamide adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17] subset: gosubset_prok synonym: "aquacob(I)alamin adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17] synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:corrinoid adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "cob(I)alamin adenosyltransferase activity" EXACT [] synonym: "CobA" RELATED [EC:2.5.1.17] synonym: "vitamin B12s adenosyltransferase activity" EXACT [EC:2.5.1.17] xref: EC:2.5.1.17 xref: GO:0008817 xref: MetaCyc:COBALADENOSYLTRANS-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0002162 name: cobalamin 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN] subset: gosubset_prok xref: GO:0008818 xref: MetaCyc:COBALAMIN5PSYN-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0002163 name: cobinamide kinase activity namespace: molecular_function def: "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [http://www.mblab.gla.ac.uk/, PMID:1655696] subset: gosubset_prok xref: EC:2.7.1.- xref: GO:0008819 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0002164 name: cobinamide phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-phosphate + GTP = adenosylcobinamide-GDP + diphosphate." [MetaCyc:COBINPGUANYLYLTRANS-RXN] subset: gosubset_prok synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT [] xref: GO:0008820 xref: MetaCyc:COBINPGUANYLYLTRANS-RXN is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0002165 name: crossover junction endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4] synonym: "crossover junction endoribonuclease activity" EXACT [] synonym: "cruciform-cutting endonuclease activity" EXACT [EC:3.1.22.-] synonym: "endo X3" RELATED [EC:3.1.22.4] synonym: "Endo X3 activity" NARROW [EC:3.1.22.-] synonym: "endodeoxyribonuclease RUS activity" EXACT [] synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-] synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-] synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-] synonym: "Hje endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction nuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction-cleaving endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-] synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-] synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-] synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-] synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-] xref: EC:3.1.22.- xref: EC:3.1.22.4 xref: GO:0008821 xref: GO:0008844 xref: MetaCyc:3.1.22.4-RXN is_a: CCO:F0003447 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0002166 name: cupric reductase activity namespace: molecular_function xref: EC:1.16.1.- xref: GO:0008823 is_a: CCO:F0003305 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: CCO:F0002167 name: cyanate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyanate (NCO-) + H2O = carbamate (H2N-CO-O-)." [EC:4.2.1.104] comment: Note that this function was formerly EC:4.3.99.1. subset: gosubset_prok synonym: "carbamate hydro-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanase activity" EXACT [] synonym: "cyanate aminohydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate C-N-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanate hydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate lyase activity" EXACT [] xref: EC:4.2.1.104 xref: GO:0008824 xref: MetaCyc:4.3.99.1-RXN xref: UM-BBD_enzymeID:e0396 is_a: CCO:F0003405 ! carbon-nitrogen lyase activity [Term] id: CCO:F0002168 name: cyclopropane-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79] subset: gosubset_prok synonym: "CFA synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthetase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" EXACT [EC:2.1.1.79] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79] xref: EC:2.1.1.79 xref: GO:0008825 xref: MetaCyc:2.1.1.79-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0002169 name: cysteine sulfinate desulfinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + SO3(2-)." [MetaCyc:RXN0-279] synonym: "cysteine sulphinate desulphinase activity" EXACT [] xref: EC:4.4.1.- xref: GO:0008826 xref: MetaCyc:RXN0-279 is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0002170 name: cytochrome o ubiquinol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2R; cytochrome O is the electron acceptor." [GOC:mah, MetaCyc:CYT-UBIQUINOL-OXID-RXN] subset: gosubset_prok xref: EC:1.10.3.- xref: GO:0008827 is_a: CCO:F0002522 ! heme-copper terminal oxidase activity is_a: CCO:F0003273 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: CCO:F0002171 name: dATP pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate." [MetaCyc:RXN0-384] subset: gosubset_prok xref: EC:3.6.1.- xref: GO:0008828 xref: MetaCyc:RXN0-384 is_a: CCO:F0006737 ! nucleoside-triphosphate diphosphatase activity [Term] id: CCO:F0002172 name: dCTP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13] subset: gosubset_prok synonym: "5-methyl-dCTP deaminase activity" EXACT [EC:3.5.4.13] synonym: "dCTP aminohydrolase activity" EXACT [EC:3.5.4.13] synonym: "deoxycytidine triphosphate deaminase activity" EXACT [EC:3.5.4.13] xref: EC:3.5.4.13 xref: GO:0008829 xref: MetaCyc:DCTP-DEAM-RXN xref: Reactome:26405 is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0002173 name: dTDP-4-dehydrorhamnose 3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13] subset: gosubset_prok synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "dTDP-L-rhamnose synthetase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13] xref: EC:5.1.3.13 xref: GO:0008830 xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0002174 name: dTDP-4-dehydrorhamnose reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+." [EC:1.1.1.133] subset: gosubset_prok synonym: "dTDP-4-keto-L-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.133] synonym: "reductase, thymidine diphospho-4-ketorhamnose" EXACT [EC:1.1.1.133] synonym: "TDP-4-keto-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "thymidine diphospho-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] xref: EC:1.1.1.133 xref: GO:0008831 xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002175 name: dGTPase activity namespace: molecular_function def: "Catalysis of the reaction: dGTP + H2O = deoxyguanosine + triphosphate." [EC:3.1.5.1] subset: gosubset_prok synonym: "deoxy-GTPase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphatase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT [] synonym: "dGTP triphosphohydrolase activity" EXACT [EC:3.1.5.1] xref: EC:3.1.5.1 xref: GO:0008832 xref: MetaCyc:DGTPTRIPHYDRO-RXN is_a: CCO:F0003363 ! triphosphoric monoester hydrolase activity [Term] id: CCO:F0002176 name: deoxyribonuclease IV (phage-T4-induced) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2] subset: gosubset_prok synonym: "deoxriboendonuclease activity" EXACT [EC:3.1.21.2] synonym: "deoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "DNA-adenine-transferase activity" EXACT [EC:3.1.21.2] synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" EXACT [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "endonuclease II" RELATED [EC:3.1.21.2] synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2] synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2] synonym: "redoxyendonuclease activity" EXACT [EC:3.1.21.2] xref: EC:3.1.21.2 xref: GO:0008833 xref: MetaCyc:3.1.21.2-RXN is_a: CCO:F0003446 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002177 name: di-trans,poly-cis-decaprenylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31] subset: gosubset_prok synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31] synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" EXACT [EC:2.5.1.31] synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl diphosphate synthase activity" EXACT [] synonym: "undecaprenyl diphosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "UPP synthetase activity" EXACT [EC:2.5.1.31] xref: EC:2.5.1.31 xref: GO:0008834 xref: MetaCyc:DECAPCISTRANSFER-RXN is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0002178 name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3." [EC:3.5.4.26] subset: gosubset_prok synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT [] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] xref: EC:3.5.4.26 xref: GO:0008485 xref: GO:0008835 xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0002179 name: diaminopimelate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2." [EC:4.1.1.20] subset: gosubset_prok synonym: "DAP decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "DAP-decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "diaminopimelic acid decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" EXACT [EC:4.1.1.20] synonym: "meso-diaminopimelate decarboxylase activity" EXACT [EC:4.1.1.20] xref: EC:4.1.1.20 xref: GO:0008836 xref: MetaCyc:DIAMINOPIMDECARB-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0002180 name: diaminopimelate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate." [EC:5.1.1.7] subset: gosubset_prok synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" EXACT [EC:5.1.1.7] xref: EC:5.1.1.7 xref: GO:0008837 xref: MetaCyc:DIAMINOPIMEPIM-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0002181 name: diaminopropionate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15] subset: gosubset_prok synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" EXACT [EC:4.3.1.15] synonym: "2,3-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "diaminopropionatase activity" EXACT [EC:4.3.1.15] xref: EC:4.3.1.15 xref: GO:0008838 xref: MetaCyc:4.3.1.15-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0002182 name: dihydrodipicolinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+." [EC:1.3.1.26] subset: gosubset_prok synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.26] synonym: "dihydrodipicolinic acid reductase activity" EXACT [EC:1.3.1.26] xref: EC:1.3.1.26 xref: GO:0008839 xref: MetaCyc:DIHYDROPICRED-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002183 name: dihydrodipicolinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate-4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O." [EC:4.2.1.52] subset: gosubset_prok synonym: "DHDPS activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinic acid synthase activity" EXACT [EC:4.2.1.52] synonym: "dihydropicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED [EC:4.2.1.52] xref: EC:4.2.1.52 xref: GO:0008840 xref: MetaCyc:DIHYDRODIPICSYN-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002184 name: dihydrofolate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12] subset: gosubset_prok synonym: "7,8-dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.12] synonym: "DHFS activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" EXACT [EC:6.3.2.12] synonym: "FHFS activity" EXACT [EC:6.3.2.12] synonym: "FHFS/FPGS activity" EXACT [EC:6.3.2.12] synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" EXACT [EC:6.3.2.12] synonym: "H(2)-folate synthetase activity" EXACT [EC:6.3.2.12] synonym: "H2-folate synthetase activity" EXACT [EC:6.3.2.12] xref: EC:6.3.2.12 xref: GO:0008841 xref: MetaCyc:DIHYDROFOLATESYNTH-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0002185 name: diphosphate-purine nucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143] synonym: "diphosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "diphosphate:purine nucleoside phosphotransferase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-purine nucleoside kinase activity" EXACT [EC:2.7.1.143] xref: EC:2.7.1.143 xref: GO:0008842 xref: MetaCyc:2.7.1.143-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004129 ! nucleoside kinase activity [Term] id: CCO:F0002186 name: endochitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin and chitodextrins." [EC:3.2.1.14] xref: GO:0008843 is_a: CCO:F0000952 ! chitinase activity [Term] id: CCO:F0002187 name: endopeptidase La activity namespace: molecular_function def: "Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [EC:3.4.21.53] subset: gosubset_prok synonym: "ATP-dependent lon proteinase" NARROW [EC:3.4.21.53] synonym: "ATP-dependent protease La activity" EXACT [EC:3.4.21.53] synonym: "ATP-dependent serine proteinase activity" RELATED [EC:3.4.21.53] synonym: "Escherichia coli proteinase La" RELATED [EC:3.4.21.53] synonym: "Escherichia coli serine proteinase La" RELATED [EC:3.4.21.53] synonym: "gene lon protease activity" EXACT [EC:3.4.21.53] synonym: "gene lon proteins" RELATED [EC:3.4.21.53] synonym: "lon proteinase" NARROW [EC:3.4.21.53] synonym: "PIM1 protease activity" EXACT [EC:3.4.21.53] synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53] synonym: "protease La" RELATED [EC:3.4.21.53] synonym: "proteinase La" RELATED [EC:3.4.21.53] synonym: "serine protease La" RELATED [EC:3.4.21.53] xref: EC:3.4.21.53 xref: GO:0008846 xref: MetaCyc:3.4.21.53-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0002188 name: Enterobacter ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.6] subset: gosubset_prok synonym: "enterobacter ribonuclease activity" EXACT [EC:3.1.27.6] synonym: "Enterobacter RNase activity" EXACT [] xref: EC:3.1.27.6 xref: GO:0008847 xref: MetaCyc:3.1.27.6-RXN is_a: CCO:F0003450 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0002189 name: enterochelin esterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the enterochelin moiety of ferric-enterochelin to yield ultimately three molecules of N-2,3-dihydroxybenzoylserine." [PMID:4565531] synonym: "enterobactin esterase activity" EXACT [] xref: GO:0008849 is_a: CCO:F0003360 ! hydrolase activity, acting on ester bonds [Term] id: CCO:F0002190 name: ethanolamine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7] subset: gosubset_prok synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" EXACT [EC:4.3.1.7] synonym: "ethanolamine deaminase activity" EXACT [EC:4.3.1.7] xref: EC:4.3.1.7 xref: GO:0008851 xref: MetaCyc:ETHAMLY-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0002191 name: exodeoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.1] subset: gosubset_prok synonym: "E. coli exonuclease I activity" NARROW [EC:3.1.11.1] synonym: "E.coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "Escherichia coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "exonuclease I activity" RELATED [EC:3.1.11.1] xref: EC:3.1.11.1 xref: GO:0008852 xref: MetaCyc:3.1.11.1-RXN is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002192 name: exodeoxyribonuclease III activity namespace: molecular_function def: "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2] subset: gosubset_prok synonym: "E. coli exonuclease III activity" NARROW [EC:3.1.11.2] synonym: "E.coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "endoribonuclease III" RELATED [EC:3.1.11.2] synonym: "Escherichia coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "exonuclease III activity" EXACT [EC:3.1.11.2] xref: EC:3.1.11.2 xref: GO:0008853 xref: MetaCyc:3.1.11.2-RXN is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002193 name: exodeoxyribonuclease V activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5] subset: gosubset_prok synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5] synonym: "E.coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "exonuclease V activity" EXACT [EC:3.1.11.5] synonym: "gene recBC DNase activity" EXACT [EC:3.1.11.5] synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5] synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5] synonym: "RecBC deoxyribonuclease activity" EXACT [EC:3.1.11.5] xref: EC:3.1.11.5 xref: GO:0008854 xref: MetaCyc:3.1.11.5-RXN is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002194 name: exodeoxyribonuclease VII activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6] subset: gosubset_prok synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6] synonym: "E.coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6] synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "exonuclease VII activity" EXACT [EC:3.1.11.6] xref: EC:3.1.11.6 xref: GO:0008855 xref: MetaCyc:3.1.11.6-RXN is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002195 name: exodeoxyribonuclease X activity namespace: molecular_function def: "Catalysis of the reaction: Endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [EC:3.1.22.5] synonym: "deoxyribonuclease X activity" EXACT [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease activity" RELATED [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease X activity" NARROW [EC:3.1.22.5] xref: EC:3.1.11.- xref: GO:0008856 is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002196 name: exonuclease IX activity namespace: molecular_function subset: gosubset_prok xref: GO:0008857 is_a: CCO:F0000923 ! exonuclease activity [Term] id: CCO:F0002197 name: exonuclease VIII activity namespace: molecular_function xref: EC:3.1.11.- xref: GO:0008858 is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002198 name: exoribonuclease II activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] subset: gosubset_prok synonym: "5'-exoribonuclease activity" EXACT [EC:3.1.13.1] synonym: "BN ribonuclease activity" EXACT [EC:3.1.13.1] synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1] synonym: "ribonuclease II activity" EXACT [EC:3.1.13.1] synonym: "ribonuclease Q" RELATED [EC:3.1.13.1] synonym: "RNase II" RELATED [EC:3.1.13.1] synonym: "RNase II activity" EXACT [] xref: EC:3.1.13.1 xref: GO:0008859 xref: MetaCyc:3.1.13.1-RXN is_a: CCO:F0001875 ! 3'-5' exonuclease activity is_a: CCO:F0003454 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002199 name: ferredoxin-NAD+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3] subset: gosubset_prok synonym: "ferredoxin-linked NAD reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin-NAD reductase activity" EXACT [] synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NAD-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH flavodoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" EXACT [EC:1.18.1.3] synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3] xref: EC:1.18.1.3 xref: GO:0008860 xref: MetaCyc:FERREDOXIN--NAD(+)-REDUCTASE-RXN is_a: CCO:F0002273 ! ferredoxin reductase activity [Term] id: CCO:F0002200 name: formate C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [EC:2.3.1.54] subset: gosubset_prok synonym: "acetyl-CoA:formate C-acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "formate acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "pyruvate formate-lyase activity" EXACT [EC:2.3.1.54] synonym: "pyruvic formate-lyase activity" EXACT [EC:2.3.1.54] xref: EC:2.3.1.54 xref: GO:0008861 xref: MetaCyc:PYRUVFORMLY-RXN is_a: CCO:F0003163 ! C-acetyltransferase activity [Term] id: CCO:F0002201 name: formate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: formate + NAD+ = CO2 + NADH + H+." [EC:1.2.1.2] subset: gosubset_prok synonym: "FDH I" RELATED [EC:1.2.1.2] synonym: "FDH II" RELATED [EC:1.2.1.2] synonym: "formate benzyl-viologen oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formate dehydrogenase (NAD)" EXACT [EC:1.2.1.2] synonym: "formate hydrogenlyase" EXACT [EC:1.2.1.2] synonym: "formate-NAD oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formate:NAD+ oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formic acid dehydrogenase" EXACT [EC:1.2.1.2] synonym: "formic hydrogen-lyase" EXACT [EC:1.2.1.2] synonym: "N-FDH" RELATED [EC:1.2.1.2] synonym: "NAD-dependent formate dehydrogenase" EXACT [EC:1.2.1.2] synonym: "NAD-formate dehydrogenase" EXACT [EC:1.2.1.2] synonym: "NAD-linked formate dehydrogenase" EXACT [EC:1.2.1.2] xref: EC:1.2.1.2 xref: GO:0008863 xref: GO:0018476 xref: MetaCyc:FORMATEDEHYDROG-RXN xref: UM-BBD_enzymeID:e0080 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002202 name: formyltetrahydrofolate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate." [EC:3.5.1.10] subset: gosubset_prok synonym: "10-formyltetrahydrofolate amidohydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyl-FH(4) hydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyltetrahydrofolate hydrolase activity" EXACT [EC:3.5.1.10] xref: EC:3.5.1.10 xref: GO:0008864 xref: MetaCyc:FORMYLTHFDEFORMYL-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0002203 name: fructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4] subset: gosubset_prok synonym: "ATP:D-fructose 6-phosphotransferase activity" EXACT [EC:2.7.1.4] synonym: "D-fructokinase activity" EXACT [EC:2.7.1.4] synonym: "D-fructose(D-mannose)kinase activity" EXACT [EC:2.7.1.4] synonym: "fructokinase (phosphorylating)" EXACT [EC:2.7.1.4] xref: EC:2.7.1.4 xref: GO:0008865 xref: MetaCyc:FRUCTOKINASE-RXN is_a: CCO:F0000807 ! hexokinase activity [Term] id: CCO:F0002204 name: fructuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+." [EC:1.1.1.57] subset: gosubset_prok synonym: "D-mannonate dehydrogenase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonic dehydrogenase activity" EXACT [EC:1.1.1.57] xref: EC:1.1.1.57 xref: GO:0008866 xref: MetaCyc:MANNONOXIDOREDUCT-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002205 name: galactarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.42] subset: gosubset_prok synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.42] synonym: "D-galactarate hydro-lyase activity" EXACT [EC:4.2.1.42] xref: EC:4.2.1.42 xref: GO:0008867 xref: MetaCyc:GALACTARDEHYDRA-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002206 name: galactitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = L-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251] subset: gosubset_prok synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.251] xref: EC:1.1.1.251 xref: GO:0008868 xref: MetaCyc:1.1.1.251-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002207 name: galactonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O." [EC:4.2.1.6] subset: gosubset_prok synonym: "D-galactonate dehydrase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate dehydratase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase activity" EXACT [EC:4.2.1.6] xref: EC:4.2.1.6 xref: GO:0008869 xref: MetaCyc:GALACTONDEHYDRAT-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002208 name: galactoside O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18] subset: gosubset_prok synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "galactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18] xref: EC:2.3.1.18 xref: GO:0008870 xref: MetaCyc:GALACTOACETYLTRAN-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0002209 name: aminoglycoside 2''-nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb] subset: gosubset_prok synonym: "2''-aminoglycoside nucleotidyltransferase activity" EXACT [EC:2.7.7.46] synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] xref: EC:2.7.7.46 xref: GO:0008871 xref: MetaCyc:2.7.7.46-RXN is_a: CCO:F0005512 ! aminoglycoside nucleotidyltransferase activity [Term] id: CCO:F0002210 name: glucarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40] subset: gosubset_prok synonym: "D-glucarate dehydratase activity" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase activity" EXACT [EC:4.2.1.40] xref: EC:4.2.1.40 xref: GO:0008872 xref: MetaCyc:GLUCARDEHYDRA-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002211 name: gluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215] subset: gosubset_prok synonym: "2-keto-D-gluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "2-ketogluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "D-gluconate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.215] xref: EC:1.1.1.215 xref: GO:0008873 xref: MetaCyc:1.1.1.215-RXN is_a: CCO:F0002213 ! gluconate dehydrogenase activity [Term] id: CCO:F0002212 name: gluconate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69] subset: gosubset_prok synonym: "5-keto-D-gluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-keto-D-gluconate reductase" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate reductase activity" EXACT [EC:1.1.1.69] synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" EXACT [EC:1.1.1.69] xref: EC:1.1.1.69 xref: GO:0008874 xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN is_a: CCO:F0002213 ! gluconate dehydrogenase activity [Term] id: CCO:F0002213 name: gluconate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215, EC:1.1.1.69] subset: gosubset_prok xref: EC:1.1.1.- xref: GO:0008875 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002214 name: quinoprotein glucose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [EC:1.1.5.2] comment: Note that this was EC:1.1.99.17. subset: gosubset_prok synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "D-glucose:ubiquinone oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (PQQ-dependent) activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT [] synonym: "quinoprotein D-glucose dehydrogenase activity" EXACT [EC:1.1.5.2] xref: EC:1.1.5.2 xref: GO:0008876 xref: MetaCyc:GLUCDEHYDROG-RXN is_a: CCO:F0000763 ! glucose dehydrogenase activity is_a: CCO:F0003459 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: CCO:F0002215 name: glucose-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10] subset: gosubset_prok synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] synonym: "D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] xref: EC:3.1.3.10 xref: GO:0008877 xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN is_a: CCO:F0004126 ! carbohydrate phosphatase activity [Term] id: CCO:F0002216 name: glucose-1-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose." [EC:2.7.7.27] subset: gosubset_prok synonym: "adenosine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "adenosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADGase activity" EXACT [] synonym: "ADP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose diphosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthetase activity" EXACT [EC:2.7.7.27] synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ADPG pyrophosphorylase activity" EXACT [] synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT [] synonym: "glucose 1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] xref: EC:2.7.7.27 xref: GO:0008878 xref: MetaCyc:GLUC1PADENYLTRANS-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002217 name: glucose-1-phosphate thymidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose." [EC:2.7.7.24] subset: gosubset_prok synonym: "dTDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose synthase activity" EXACT [EC:2.7.7.24] synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "glucose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "TDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] xref: EC:2.7.7.24 xref: GO:0008879 xref: MetaCyc:DTDPGLUCOSEPP-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002218 name: glucuronate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronate = D-fructuronate." [EC:5.3.1.12] subset: gosubset_prok synonym: "D-glucuronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate ketol-isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic acid isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic isomerase activity" EXACT [EC:5.3.1.12] xref: EC:5.3.1.12 xref: GO:0008880 xref: MetaCyc:GLUCUROISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0002219 name: glutamate racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3] subset: gosubset_prok xref: EC:5.1.1.3 xref: GO:0008881 xref: MetaCyc:GLUTRACE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0002221 name: glutamyl-tRNA reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+." [EC:1.2.1.70, MetaCyc:GLUTRNAREDUCT-RXN] subset: gosubset_prok synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" EXACT [EC:1.2.1.70] xref: EC:1.2.1.70 xref: GO:0008883 xref: MetaCyc:GLUTRNAREDUCT-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002222 name: glutathionylspermidine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" EXACT [EC:3.5.1.78] synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" EXACT [EC:3.5.1.78] synonym: "GSP amidase activity" EXACT [EC:3.5.1.78] xref: EC:3.5.1.78 xref: GO:0008884 xref: MetaCyc:GSPAMID-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0002223 name: glutathionylspermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8] synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathione:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathionylspermidine synthetase activity" EXACT [EC:6.3.1.8] synonym: "GSP synthetase activity" EXACT [EC:6.3.1.8] xref: EC:6.3.1.8 xref: GO:0008885 xref: MetaCyc:GSPSYN-RXN is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0002224 name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+." [EC:1.2.1.9] subset: gosubset_prok synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT [] synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD [] synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT [] synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD [] synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9] xref: EC:1.2.1.9 xref: GO:0008886 xref: MetaCyc:1.2.1.9-RXN is_a: CCO:F0002279 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: CCO:F0002225 name: glycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate." [EC:2.7.1.31] subset: gosubset_prok synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "ATP:D-glycerate 2-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate 3-kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glyceric acid kinase activity" EXACT [EC:2.7.1.31] synonym: "GK" RELATED [EC:2.7.1.31] synonym: "glycerate kinase (phosphorylating)" EXACT [EC:2.7.1.31] synonym: "glycerate-3-kinase activity" EXACT [EC:2.7.1.31] xref: EC:2.7.1.31 xref: GO:0008887 xref: MetaCyc:GLY3KIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0002226 name: glycerol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NAD+ = glycerone + NADH + H+." [EC:1.1.1.6] subset: gosubset_prok synonym: "NAD-linked glycerol dehydrogenase activity" EXACT [EC:1.1.1.6] xref: EC:1.1.1.6 xref: GO:0008888 xref: MetaCyc:GLYCDEH-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002227 name: glycerophosphodiester phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] subset: gosubset_prok synonym: "gene hpd protein" RELATED [EC:3.1.4.46] synonym: "glycerophosphodiester glycerophosphohydrolase activity" EXACT [EC:3.1.4.46] synonym: "glycerophosphoryl diester phosphodiesterase activity" EXACT [EC:3.1.4.46] synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46] xref: EC:3.1.4.46 xref: GO:0008889 xref: MetaCyc:GLYCPDIESTER-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0002228 name: glycine C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate." [EC:2.3.1.29] subset: gosubset_prok synonym: "2-amino-3-ketobutyrate CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate coenzyme A ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate-CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "acetyl-CoA:glycine C-acetyltransferase activity" EXACT [EC:2.3.1.29] synonym: "aminoacetone synthase activity" EXACT [EC:2.3.1.29] synonym: "glycine acetyltransferase activity" EXACT [EC:2.3.1.29] xref: EC:2.3.1.29 xref: GO:0008890 xref: MetaCyc:AKBLIG-RXN is_a: CCO:F0003163 ! C-acetyltransferase activity [Term] id: CCO:F0002229 name: glycolate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + H2O2." [EC:1.1.3.15] subset: gosubset_prok xref: GO:0008891 xref: MetaCyc:RXN-969 is_a: CCO:F0008250 ! (S)-2-hydroxy-acid oxidase activity [Term] id: CCO:F0002230 name: guanine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3] subset: gosubset_prok synonym: "GAH activity" EXACT [EC:3.5.4.3] synonym: "guanase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminohydrolase activity" EXACT [EC:3.5.4.3] xref: EC:3.5.4.3 xref: GO:0008892 xref: MetaCyc:GUANINE-DEAMINASE-RXN xref: Reactome:26482 is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0002231 name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2] subset: gosubset_prok synonym: "(ppGpp)ase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT [] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT [] synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp phosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] xref: EC:3.1.7.2 xref: GO:0008893 xref: MetaCyc:PPGPPSYN-RXN is_a: CCO:F0003364 ! diphosphoric monoester hydrolase activity [Term] id: CCO:F0002232 name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40] subset: gosubset_prok synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT [] synonym: "pppGpp 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] xref: EC:3.6.1.40 xref: GO:0008894 xref: MetaCyc:PPPGPPHYDRO-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0002233 name: heme lyase disulfide oxidoreductase activity namespace: molecular_function synonym: "haem lyase disulfide oxidoreductase activity" EXACT [] synonym: "heme lyase disulphide oxidoreductase activity" EXACT [] xref: GO:0008895 is_a: CCO:F0002532 ! protein disulfide oxidoreductase activity [Term] id: CCO:F0002234 name: phosphopantetheinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709] subset: gosubset_prok synonym: "4'-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "4'-phosphopantetheinyltransferase activity" EXACT [] synonym: "AcpS" RELATED [EC:2.7.8.7] synonym: "ACPS activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" EXACT [EC:2.7.8.7] synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7] synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT [] synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" EXACT [EC:2.7.8.7] synonym: "holo-[acyl-carrier-protein] synthase activity" NARROW [] synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW [] synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7] synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7] synonym: "holo-acyl-carrier-protein synthase activity" EXACT [EC:2.7.8.7] synonym: "holosynthase activity" RELATED [EC:2.7.8.7] synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7] synonym: "P-pant transferase activity" EXACT [EC:2.7.8.7] synonym: "PPTase activity" EXACT [EC:2.7.8.7] xref: EC:2.7.8.7 xref: GO:0008897 xref: GO:0008958 xref: MetaCyc:HOLO-ACP-SYNTH-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0002235 name: homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10] subset: gosubset_prok synonym: "adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "methylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine-homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-methylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] xref: EC:2.1.1.10 xref: GO:0008898 xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN is_a: CCO:F0001759 ! S-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0002236 name: homoserine O-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine." [EC:2.3.1.46] subset: gosubset_prok synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46] synonym: "homoserine succinyltransferase activity" EXACT [EC:2.3.1.46] synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" EXACT [EC:2.3.1.46] xref: EC:2.3.1.46 xref: GO:0008899 xref: MetaCyc:HOMSUCTRAN-RXN is_a: CCO:F0003325 ! O-succinyltransferase activity [Term] id: CCO:F0002237 name: hydrogen:potassium-exchanging ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [EC:3.6.3.10] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "(K+ + H+)-ATPase activity" EXACT [EC:3.6.3.10] synonym: "ATP phosphohydrolase (H+/K+-exchanging)" EXACT [EC:3.6.3.10] synonym: "gastric H(+)/K(+) ATPase activity" NARROW [EC:3.6.3.10] synonym: "gastric H+/K+ ATPase" NARROW [EC:3.6.3.10] synonym: "H(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+-K+-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+/K+-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "h+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "H,K-ATPase activity" EXACT [EC:3.6.3.10] synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT [] synonym: "hydrogen:potassium exchanging ATPase activity" EXACT [] synonym: "proton pump activity" BROAD [EC:3.6.3.10] xref: EC:3.6.3.10 xref: GO:0005390 xref: GO:0008900 xref: MetaCyc:3.6.3.10-RXN is_a: CCO:F0002559 ! hydrogen ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0002238 name: ferredoxin hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2] comment: Note that this function was formerly EC 1.12.1.1, EC 1.12.7.1, EC 1.98.1.1, EC 1.18.3.1 and EC 1.18.99.1. subset: gosubset_prok synonym: "[Fe] hydrogenase activity" EXACT [] synonym: "[Fe] hydrogenase gamma" RELATED [] synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H2 oxidizing hydrogenase" BROAD [] synonym: "H2 producing hydrogenase" BROAD [] synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2] synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT [] synonym: "hydrogenase (ferredoxin) activity" EXACT [EC:1.12.7.2] synonym: "hydrogenase activity" BROAD [] synonym: "hydrogenase I" RELATED [] synonym: "hydrogenase II" RELATED [] synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2] synonym: "iron hydrogenase activity" NARROW [] synonym: "iron-only hydrogenase activity" NARROW [] synonym: "Ni-Fe hydrogenase activity" NARROW [] synonym: "Ni-Fe-Se hydrogenase activity" NARROW [] synonym: "nickel hydrogenase activity" NARROW [] synonym: "nickel-iron hydrogenase activity" NARROW [] synonym: "nickel-iron-selenium hydrogenase activity" NARROW [] synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2] xref: EC:1.12.7.2 xref: GO:0008901 xref: GO:0016948 xref: GO:0016949 xref: GO:0016950 xref: GO:0016951 xref: MetaCyc:HYDROG-RXN xref: UM-BBD_enzymeID:e0418 is_a: CCO:F0003284 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor [Term] id: CCO:F0002239 name: hydroxymethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-hydroxymethylpyrimidine = ADP + 4-amino-2-methyl-5-phosphomethylpyrimidine." [EC:2.7.1.49] subset: gosubset_prok synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" EXACT [EC:2.7.1.49] synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" EXACT [EC:2.7.1.49] xref: EC:2.7.1.49 xref: GO:0008902 xref: MetaCyc:OHMETPYRKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0002240 name: hydroxypyruvate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22] subset: gosubset_prok synonym: "hydroxypyruvate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.22] synonym: "hydroxypyruvate ketol-isomerase activity" EXACT [EC:5.3.1.22] xref: EC:5.3.1.22 xref: GO:0008903 xref: MetaCyc:RXN0-305 is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0002241 name: aminoglycoside 7''-O-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + 7''-O-phosphoaminoglycoside." [EC:2.7.1.119, GOC:cb, GOC:mah] subset: gosubset_prok synonym: "APH(7'') activity" EXACT [EC:2.7.1.119] synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" NARROW [EC:2.7.1.119] synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT [] synonym: "hygromycin B kinase activity" NARROW [] synonym: "hygromycin B phosphotransferase activity" NARROW [EC:2.7.1.119] synonym: "hygromycin-B kinase activity" NARROW [] xref: EC:2.7.1.119 xref: GO:0008904 xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN is_a: CCO:F0005515 ! aminoglycoside phosphotransferase activity [Term] id: CCO:F0002242 name: mannose-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.7.7.- xref: GO:0008905 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002243 name: inosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73] subset: gosubset_prok synonym: "ATP:inosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.73] synonym: "inosine kinase (phosphorylating)" EXACT [EC:2.7.1.73] synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73] xref: EC:2.7.1.73 xref: GO:0008906 xref: MetaCyc:INOSINEKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0002244 name: integrase activity namespace: molecular_function def: "Catalysis of the integration of lambdoid phage DNA during establishment, probably by forming a transient DNA-protein link." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_goa subset: goslim_pir subset: gosubset_prok xref: GO:0008907 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0002245 name: isochorismatase activity namespace: molecular_function def: "Catalysis of the reaction: isochorismate + H2O = 2,3-dihydro-2,3-dihydroxybenzoate + pyruvate." [EC:3.3.2.1] subset: gosubset_prok synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" EXACT [EC:3.3.2.1] synonym: "isochorismate pyruvate-hydrolase activity" EXACT [EC:3.3.2.1] xref: EC:3.3.2.1 xref: GO:0008908 xref: MetaCyc:ISOCHORMAT-RXN is_a: CCO:F0000863 ! leukotriene-A4 hydrolase activity [Term] id: CCO:F0002246 name: isochorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.99.6] comment: Note that this function was formerly EC:5.4.99.6. subset: gosubset_prok synonym: "isochorismate hydroxymutase activity" EXACT [EC:5.4.4.2] synonym: "isochorismate mutase activity" EXACT [] synonym: "isochorismate synthetase activity" EXACT [EC:5.4.4.2] xref: EC:5.4.4.2 xref: GO:0008909 xref: MetaCyc:ISOCHORSYN-RXN is_a: CCO:F0007827 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: CCO:F0002247 name: kanamycin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + kanamycin = ADP + kanamycin 3'-phosphate." [EC:2.7.1.95] subset: gosubset_prok synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "APH(3') activity" EXACT [EC:2.7.1.95] synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95] synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "neomycin-kanamycin phosphotransferase activity" EXACT [EC:2.7.1.95] xref: EC:2.7.1.95 xref: GO:0008910 xref: MetaCyc:KANAMYCIN-KINASE-RXN is_a: CCO:F0005515 ! aminoglycoside phosphotransferase activity [Term] id: CCO:F0002248 name: lactaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [EC:1.2.1.22] subset: gosubset_prok synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "L-lactaldehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" EXACT [EC:1.2.1.22] xref: EC:1.2.1.22 xref: GO:0008911 xref: MetaCyc:LACTALDDEHYDROG-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002249 name: lactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R) (or (S))-propane-1,2-diol + NAD+ = (R) (or (S))-lactaldehyde + NADH + H+." [EC:1.1.1.77] subset: gosubset_prok synonym: "(R)[or (S)]-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "L-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" EXACT [EC:1.1.1.77] xref: EC:1.1.1.77 xref: GO:0008912 xref: MetaCyc:LACTALDREDUCT-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002250 name: lauroyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "lauroyl transferase activity" EXACT [] xref: GO:0008913 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0002251 name: leucyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein." [EC:2.3.2.6] subset: gosubset_prok synonym: "L-leucyl-tRNA:protein leucyltransferase activity" EXACT [EC:2.3.2.6] synonym: "L/F transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl, phenylalanine-tRNA-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] xref: EC:2.3.2.6 xref: GO:0008914 xref: MetaCyc:LEUCYLTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0002252 name: lipid-A-disaccharide synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate." [EC:2.4.1.182] subset: gosubset_prok synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" EXACT [EC:2.4.1.182] xref: EC:2.4.1.182 xref: GO:0008915 xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0002253 name: lipopolysaccharide N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56] subset: gosubset_prok synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT [] synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] xref: EC:2.4.1.56 xref: GO:0008917 xref: MetaCyc:2.4.1.56-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0002254 name: lipopolysaccharide 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44] subset: gosubset_prok synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "lipopolysaccharide galactosyltransferase activity" EXACT [] synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW [] synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] xref: EC:2.4.1.44 xref: GO:0008918 xref: MetaCyc:2.4.1.44-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0002255 name: lipopolysaccharide glucosyltransferase I activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58] subset: gosubset_prok synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "LPS glucosyltransferase I activity" EXACT [] synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] xref: EC:2.4.1.58 xref: GO:0008919 xref: MetaCyc:2.4.1.58-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0002256 name: lipopolysaccharide heptosyltransferase activity namespace: molecular_function subset: gosubset_prok synonym: "LPS heptosyltransferase activity" EXACT [] xref: GO:0008920 is_a: CCO:F0003332 ! transferase activity, transferring glycosyl groups [Term] id: CCO:F0002257 name: lipopolysaccharide-1,6-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai] synonym: "LPS-1,6-galactosyltransferase activity" EXACT [] xref: EC:2.4.1.- xref: GO:0008921 is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0002258 name: long-chain-fatty-acid-[acyl-carrier-protein] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]." [EC:6.2.1.20] subset: gosubset_prok synonym: "acyl-[acyl-carrier-protein] synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-ACP synthetase activity" EXACT [] synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20] synonym: "acyl-acyl-carrier-protein synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-acyl-carrier-proteinsynthetase activity" EXACT [EC:6.2.1.20] synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT [] synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" EXACT [EC:6.2.1.20] synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" EXACT [EC:6.2.1.20] synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20] xref: EC:6.2.1.20 xref: GO:0008922 xref: GO:0010300 xref: MetaCyc:ACYLACPSYNTH-RXN is_a: CCO:F0002996 ! fatty-acid ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0002259 name: lysine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine = cadaverine + CO2." [EC:4.1.1.18] subset: gosubset_prok synonym: "L-lysine carboxy-lyase (cadaverine-forming)" EXACT [EC:4.1.1.18] synonym: "L-lysine carboxy-lyase activity" EXACT [EC:4.1.1.18] xref: EC:4.1.1.18 xref: GO:0008923 xref: MetaCyc:LYSDECARBOX-RXN xref: MetaCyc:PWY0-461 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0002260 name: malate dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + acceptor = oxaloacetate + reduced acceptor." [EC:1.1.99.16] subset: gosubset_prok synonym: "(S)-malate:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.16] synonym: "(S)-malate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.16] synonym: "FAD-dependent malate-vitamin K reductase activity" EXACT [] synonym: "malate-vitamin K reductase activity" EXACT [] xref: EC:1.1.99.16 xref: GO:0008924 xref: MetaCyc:MALATE-DEHYDROGENASE-(ACCEPTOR)-RXN is_a: CCO:F0003217 ! malate dehydrogenase activity [Term] id: CCO:F0002261 name: maltose O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79] subset: gosubset_prok synonym: "acetyl-CoA:maltose O-acetyltransferase activity" EXACT [EC:2.3.1.79] synonym: "maltose transacetylase activity" EXACT [EC:2.3.1.79] xref: EC:2.3.1.79 xref: GO:0008925 xref: MetaCyc:MALTACETYLTRAN-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0002262 name: mannitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17] subset: gosubset_prok xref: EC:1.1.1.17 xref: GO:0008926 xref: MetaCyc:MANNPDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002263 name: mannonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.8] subset: gosubset_prok synonym: "altronate hydrolase activity" EXACT [EC:4.2.1.8] synonym: "altronic hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonic hydrolase activity" EXACT [EC:4.2.1.8] xref: EC:4.2.1.8 xref: GO:0008927 xref: MetaCyc:MANNONDEHYDRAT-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002264 name: mannose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + D-mannose 1-phosphate = phosphate + GDP-mannose." [EC:2.7.7.22] subset: gosubset_prok synonym: "GDP mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22] synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "guanosine diphosphomannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] xref: EC:2.7.7.22 xref: GO:0008928 xref: MetaCyc:MANNPGUANYLTRANGDP-RXN is_a: CCO:F0002242 ! mannose-phosphate guanylyltransferase activity [Term] id: CCO:F0002265 name: methylglyoxal synthase activity namespace: molecular_function def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3] subset: gosubset_prok synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" EXACT [EC:4.2.3.3] synonym: "glycerone-phosphate phospho-lyase activity" EXACT [EC:4.2.3.3] synonym: "methylglyoxal synthetase activity" EXACT [EC:4.2.3.3] xref: EC:4.2.3.3 xref: GO:0008929 xref: MetaCyc:METHGLYSYN-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0002266 name: methylthioadenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16] subset: gosubset_prok synonym: "5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "MeSAdo nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "methylthioadenosine methylthioribohydrolase activity" EXACT [EC:3.2.2.16] synonym: "MTA nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" EXACT [EC:3.2.2.16] xref: EC:3.2.2.16 xref: GO:0008930 xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0002267 name: murein DD-endopeptidase activity namespace: molecular_function subset: gosubset_prok xref: GO:0008931 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0002268 name: lytic endotransglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199] synonym: "murein lytic endotransglycosylase E activity" NARROW [] xref: EC:2.4.99.- xref: GO:0008932 is_a: CCO:F0002269 ! lytic transglycosylase activity [Term] id: CCO:F0002269 name: lytic transglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424] synonym: "murein transglycosylase B activity" NARROW [] xref: EC:3.2.1.- xref: GO:0008933 is_a: CCO:F0003332 ! transferase activity, transferring glycosyl groups [Term] id: CCO:F0002270 name: inositol-1(or 4)-monophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] subset: gosubset_prok synonym: "inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "inositol monophosphate phosphatase activity" BROAD [EC:3.1.3.25] synonym: "inositol phosphatase activity" BROAD [EC:3.1.3.25] synonym: "inositol-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "L-myo-inositol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol monophosphatase activity" BROAD [EC:3.1.3.25] synonym: "myo-inositol-1(or 4)-monophosphatase activity" EXACT [] synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] xref: EC:3.1.3.25 xref: GO:0008934 xref: MetaCyc:MYO-INOSITOL-1(OR-4)-MONOPHOSPHATASE-RXN is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity [Term] id: CCO:F0002271 name: naphthoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA." [EC:4.1.3.36] subset: gosubset_prok synonym: "1,4-dihydroxy-2-naphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "DHNA synthetase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoic acid synthetase activity" EXACT [EC:4.1.3.36] synonym: "o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" EXACT [EC:4.1.3.36] synonym: "o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing; CoA-forming)" EXACT [EC:4.1.3.36] xref: EC:4.1.3.36 xref: GO:0008935 xref: MetaCyc:NAPHTHOATE-SYN-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0002272 name: nicotinamidase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19] subset: gosubset_prok synonym: "NAMase activity" EXACT [EC:3.5.1.19] synonym: "namase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidohydrolase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide deaminase activity" EXACT [EC:3.5.1.19] synonym: "nicotine deamidase activity" EXACT [EC:3.5.1.19] synonym: "YNDase activity" EXACT [EC:3.5.1.19] xref: EC:3.5.1.19 xref: GO:0008936 xref: MetaCyc:NICOTINAMID-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0002273 name: ferredoxin reductase activity namespace: molecular_function def: "Catalysis of the reactions: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [EC:1.18.1.-] subset: gosubset_prok xref: EC:1.18.1.- xref: GO:0008937 is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003312 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: CCO:F0002274 name: nicotinate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate." [EC:2.1.1.7] synonym: "furanocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.7] synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" EXACT [EC:2.1.1.7] xref: EC:2.1.1.7 xref: GO:0008938 xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0002275 name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-nicotinate D-ribonucleotide + dimethylbenzimidazole = nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole." [EC:2.4.2.21] subset: gosubset_prok synonym: "CobT" RELATED [EC:2.4.2.21] synonym: "N(1)-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "N1-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] xref: EC:2.4.2.21 xref: GO:0008939 xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0002276 name: nitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: NO2- (nitrite) + acceptor = NO3- (nitrate) + reduced acceptor." [EC:1.7.99.4] subset: gosubset_prok synonym: "nitrate reductase (acceptor)" EXACT [EC:1.7.99.4] synonym: "nitrite:(acceptor) oxidoreductase" EXACT [EC:1.7.99.4] synonym: "nitrite:acceptor oxidoreductase" EXACT [EC:1.7.99.4] synonym: "respiratory nitrate reductase activity" NARROW [EC:1.7.99.4] xref: EC:1.7.99.4 xref: GO:0008940 xref: MetaCyc:NITRATREDUCT-RXN is_a: CCO:F0003256 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: CCO:F0002277 name: nitric oxide dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 NO3- + NADP+." [EC:1.14.12.17] subset: gosubset_prok synonym: "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.12.17] synonym: "NOD activity" EXACT [EC:1.14.12.17] xref: EC:1.14.12.17 xref: GO:0008941 xref: MetaCyc:1.14.12.17-RXN is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0002278 name: nitrite reductase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = NO2(-) (nitrite) + 3 NAD(P)H + 3 H+." [EC:1.7.1.4] comment: Note that this function was formerly EC:1.6.6.4. subset: gosubset_prok synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4] synonym: "NAD(P)H2:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NAD(P)H:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADH-nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADPH-nitrite reductase activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4] xref: EC:1.7.1.4 xref: GO:0008942 xref: MetaCyc:NITRITREDUCT-RXN is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0002279 name: glyceraldehyde-3-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+." [EC:1.2.1.12, EC:1.2.1.13, EC:1.2.1.9] comment: Note that the reaction with phosphate as a substrate produces 3-phospho-D-glyceroyl-phosphate. subset: gosubset_prok xref: EC:1.2.1.- xref: GO:0008943 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002280 name: oligopeptidase A activity namespace: molecular_function def: "Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [EC:3.4.24.70] subset: gosubset_prok synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70] xref: EC:3.4.24.70 xref: GO:0008944 xref: MetaCyc:3.4.24.70-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0002281 name: oligopeptidase B activity namespace: molecular_function def: "Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [EC:3.4.21.83] subset: gosubset_prok synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83] synonym: "protease II activity" EXACT [EC:3.4.21.83] xref: EC:3.4.21.83 xref: GO:0008945 xref: MetaCyc:3.4.21.83-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0002282 name: oligonucleotidase activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates; also hydrolyzes NAD+ to NMN and AMP." [EC:3.1.13.3] subset: gosubset_prok synonym: "oligoribonuclease activity" EXACT [] xref: EC:3.1.13.3 xref: GO:0008946 xref: MetaCyc:3.1.13.3-RXN is_a: CCO:F0000934 ! ribonuclease activity is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002283 name: omptin activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87] subset: gosubset_prok xref: EC:3.4.21.87 xref: GO:0008947 xref: MetaCyc:3.4.21.87-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0002284 name: oxaloacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate = pyruvate + CO2." [EC:4.1.1.3] subset: gosubset_prok synonym: "oxalacetic acid decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxalate beta-decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxaloacetate beta-decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.3] synonym: "oxaloacetate carboxy-lyase activity" EXACT [EC:4.1.1.3] xref: EC:4.1.1.3 xref: GO:0008948 xref: MetaCyc:OXALODECARB-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0002285 name: oxalyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: oxalyl-CoA = formyl-CoA + CO2." [EC:4.1.1.8] subset: gosubset_prok synonym: "oxalyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.8] xref: EC:4.1.1.8 xref: GO:0008949 xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0002286 name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity namespace: molecular_function synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT [] xref: EC:2.3.1.- xref: GO:0008951 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0002287 name: penicillin amidase activity namespace: molecular_function def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11] subset: gosubset_prok synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" EXACT [EC:3.5.1.11] synonym: "ampicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "benzylpenicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "novozym 217" RELATED [EC:3.5.1.11] synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT [] synonym: "penicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "penicillin amidohydrolase activity" EXACT [EC:3.5.1.11] synonym: "semacylase activity" EXACT [EC:3.5.1.11] xref: EC:3.5.1.11 xref: GO:0008953 xref: MetaCyc:PENICILLIN-AMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0002288 name: peptidoglycan synthetase activity namespace: molecular_function subset: gosubset_prok xref: GO:0008954 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0002289 name: peptidoglycan glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate." [EC:2.4.1.129] subset: gosubset_prok synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.129] synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.1.129] synonym: "peptidoglycan TGase activity" EXACT [EC:2.4.1.129] synonym: "peptidoglycan transglycosylase activity" EXACT [EC:2.4.1.129] synonym: "PG-II activity" EXACT [EC:2.4.1.129] synonym: "undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129] xref: EC:2.4.1.129 xref: GO:0008955 xref: MetaCyc:PEPTIDOGLYCAN-GLYCOSYLTRANSFERASE-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0002290 name: peptidyl-dipeptidase Dcp activity namespace: molecular_function def: "Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5] subset: gosubset_prok synonym: "dipeptidyl carboxypeptidase (Dcp)" EXACT [EC:3.4.15.5] synonym: "dipeptidyl carboxypeptidase activity" EXACT [EC:3.4.15.5] xref: EC:3.4.15.5 xref: GO:0008956 xref: MetaCyc:3.4.15.5-RXN is_a: CCO:F0001785 ! metalloexopeptidase activity is_a: CCO:F0001791 ! peptidyl-dipeptidase activity [Term] id: CCO:F0002291 name: phenylacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+." [EC:1.2.1.39] subset: gosubset_prok synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.39] xref: EC:1.2.1.39 xref: GO:0008957 xref: MetaCyc:PHENDEHYD-RXN xref: UM-BBD_enzymeID:e0119 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002292 name: phosphate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8] subset: gosubset_prok synonym: "acetyl-CoA:phosphate acetyltransferase activity" EXACT [EC:2.3.1.8] synonym: "phosphoacylase activity" EXACT [EC:2.3.1.8] synonym: "phosphotransacetylase activity" EXACT [EC:2.3.1.8] synonym: "PTA" RELATED [EC:2.3.1.8] xref: EC:2.3.1.8 xref: GO:0008959 xref: MetaCyc:PHOSACETYLTRANS-RXN is_a: CCO:F0003130 ! acetyltransferase activity [Term] id: CCO:F0002293 name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20] subset: gosubset_prok synonym: "oligosaccharide glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20] synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20] xref: EC:2.7.8.20 xref: GO:0008960 xref: MetaCyc:PGLYCEROLTRANSI-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0002294 name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity namespace: molecular_function subset: gosubset_prok xref: GO:0008961 is_a: CCO:F0003332 ! transferase activity, transferring glycosyl groups [Term] id: CCO:F0002295 name: phosphatidylglycerophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [EC:3.1.3.27] subset: gosubset_prok synonym: "PGP phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphate phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerophosphate phosphohydrolase activity" EXACT [EC:3.1.3.27] xref: EC:3.1.3.27 xref: GO:0008962 xref: MetaCyc:PGPPHOSPHA-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0002296 name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13] subset: gosubset_prok synonym: "MraY transferase activity" NARROW [EC:2.7.8.13] synonym: "phospho-MurNAc-pentapeptide transferase activity" EXACT [EC:2.7.8.13] synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13] xref: EC:2.7.8.13 xref: GO:0008963 xref: MetaCyc:PHOSNACMURPENTATRANSLYS-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0002297 name: phosphoenolpyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2." [EC:4.1.1.31] subset: gosubset_prok synonym: "PEP carboxylase activity" EXACT [EC:4.1.1.31] synonym: "PEPC" RELATED [EC:4.1.1.31] synonym: "PEPCase activity" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" EXACT [EC:4.1.1.31] synonym: "phosphoenolpyruvic carboxylase activity" EXACT [EC:4.1.1.31] synonym: "phosphopyruvate (phosphate) carboxylase activity" EXACT [EC:4.1.1.31] xref: EC:4.1.1.31 xref: GO:0008964 xref: MetaCyc:PEPCARBOX-RXN is_a: CCO:F0000990 ! phosphoenolpyruvate carboxykinase activity [Term] id: CCO:F0002298 name: phosphoenolpyruvate-protein phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9] subset: gosubset_prok synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9] synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate--protein phosphatase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein factor phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9] xref: EC:2.7.3.9 xref: GO:0008965 xref: MetaCyc:2.7.3.9-RXN is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0002299 name: phosphoglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10] subset: gosubset_prok synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] synonym: "D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] xref: EC:5.4.2.10 xref: GO:0008966 xref: MetaCyc:5.4.2.10-RXN is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0002300 name: phosphoglycolate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate." [EC:3.1.3.18] subset: gosubset_prok synonym: "2-phosphoglycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "2-phosphoglycolate phosphohydrolase activity" EXACT [EC:3.1.3.18] synonym: "P-glycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycolate hydrolase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycollate phosphatase activity" EXACT [EC:3.1.3.18] xref: EC:3.1.3.18 xref: GO:0008967 xref: MetaCyc:GPH-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0002301 name: D-sedoheptulose 7-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969] subset: gosubset_prok synonym: "phosphoheptose isomerase activity" EXACT [] xref: GO:0008968 xref: MetaCyc:RXN0-4301 is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0002302 name: phosphohistidine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate." [GOC:mah] subset: gosubset_prok xref: EC:3.1.3.- xref: GO:0008969 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0002303 name: phospholipase A1 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] subset: gosubset_prok synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT [EC:3.1.1.32] xref: EC:3.1.1.32 xref: GO:0008970 xref: MetaCyc:PHOSPHOLIPASE-A1-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0000999 ! phospholipase activity [Term] id: CCO:F0002304 name: phosphomethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7] subset: gosubset_prok synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" EXACT [EC:2.7.4.7] synonym: "hydroxymethylpyrimidine phosphokinase activity" EXACT [EC:2.7.4.7] xref: EC:2.7.4.7 xref: GO:0008972 xref: MetaCyc:PYRIMSYN3-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0002305 name: phosphopentomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7] subset: gosubset_prok synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.7] synonym: "alpha-D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphoribomutase activity" EXACT [EC:5.4.2.7] xref: EC:5.4.2.7 xref: GO:0008973 xref: MetaCyc:PPENTOMUT-RXN is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0002306 name: phosphoribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate." [EC:2.7.1.19] subset: gosubset_prok synonym: "5-phosphoribulose kinase activity" EXACT [EC:2.7.1.19] synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.19] synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19] synonym: "phosphoribulokinase (phosphorylating)" EXACT [EC:2.7.1.19] synonym: "PKK" RELATED [EC:2.7.1.19] synonym: "PRK" RELATED [EC:2.7.1.19] synonym: "PRuK" RELATED [EC:2.7.1.19] synonym: "ribulose phosphate kinase activity" EXACT [EC:2.7.1.19] synonym: "ribulose-5-phosphate kinase activity" EXACT [EC:2.7.1.19] xref: EC:2.7.1.19 xref: GO:0008974 xref: MetaCyc:PHOSPHORIBULOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0002307 name: pitrilysin activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [EC:3.4.24.55] subset: gosubset_prok synonym: "Escherichia coli metalloproteinase Pi" RELATED [EC:3.4.24.55] synonym: "Escherichia coli protease III" RELATED [EC:3.4.24.55] synonym: "protease III activity" EXACT [EC:3.4.24.55] synonym: "protease Pi activity" EXACT [EC:3.4.24.55] synonym: "proteinase Pi" RELATED [EC:3.4.24.55] synonym: "PTR" RELATED [EC:3.4.24.55] xref: EC:3.4.24.55 xref: GO:0008975 xref: MetaCyc:3.4.24.55-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0002308 name: polyphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1] subset: gosubset_prok synonym: "ATP-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "ATP:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1] xref: EC:2.7.4.1 xref: GO:0008976 xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0002309 name: prephenate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+." [EC:1.3.1.12] subset: gosubset_prok synonym: "chorismate mutase--prephenate dehydrogenase activity" EXACT [EC:1.3.1.12] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12] synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.12] xref: EC:1.3.1.12 xref: GO:0008977 xref: MetaCyc:PREPHENATEDEHYDROG-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002310 name: prepilin peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43] subset: gosubset_prok xref: EC:3.4.23.43 xref: GO:0008978 xref: MetaCyc:3.4.23.43-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0002311 name: prophage integrase activity namespace: molecular_function subset: gosubset_prok xref: GO:0008979 is_a: CCO:F0002244 ! integrase activity [Term] id: CCO:F0002312 name: propionate kinase activity namespace: molecular_function def: "Catalysis of the reactions: (1) ATP + propanoate = ADP + propanoyl phosphate (2) ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.15] subset: gosubset_prok synonym: "ATP:propanoate phosphotransferase activity" EXACT [] synonym: "PduW" RELATED [] synonym: "propanoate kinase activity" EXACT [] synonym: "propionate/acetate kinase activity" EXACT [] synonym: "TdcD" RELATED [] xref: EC:2.7.2.15 xref: GO:0008980 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0002313 name: protease IV activity namespace: molecular_function subset: gosubset_prok xref: GO:0008981 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0002314 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-] subset: gosubset_prok synonym: "enzyme II of the phosphotransferase system" NARROW [EC:2.7.1.69] synonym: "enzyme IIl4ac" RELATED [EC:2.7.1.69] synonym: "gene bglC RNA formation factors" RELATED [EC:2.7.1.69] synonym: "gene glC proteins" RELATED [EC:2.7.1.69] synonym: "group translocator activity" RELATED [EC:2.7.1.69] synonym: "PEP--sugar phosphotransferase enzyme II activity" NARROW [EC:2.7.1.69] synonym: "PEP-dependent phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphoribosyltransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphoprotein factor-hexose phosophotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphotransfer-driven group translocator" EXACT [] synonym: "phosphotransferase, phosphohistidinoprotein-hexose activity" EXACT [EC:2.7.1.69] synonym: "protein, specific or class, gene bglC" RELATED [EC:2.7.1.69] synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT [] synonym: "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine-sugar phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "PTS permease activity" EXACT [EC:2.7.1.69] synonym: "PTS transporter" RELATED [EC:2.7.1.69] synonym: "ribonucleic acid formation factor, gene glC" RELATED [EC:2.7.1.69] synonym: "sucrose phosphotransferase system II" RELATED [EC:2.7.1.69] xref: EC:2.7.1.69 xref: GO:0008982 xref: GO:0015455 xref: GO:0015456 xref: MetaCyc:2.7.1.69-RXN is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004251 ! active transmembrane transporter activity [Term] id: CCO:F0002315 name: protein-glutamate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80, RESID:AA0072] subset: gosubset_prok synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80] synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80] synonym: "protein carboxyl-methylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxyl-O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80] synonym: "protein carboxymethylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxymethyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein methylase II" RELATED [EC:2.1.1.80] synonym: "protein O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(aspartate)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(carboxyl)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EXACT [EC:2.1.1.80] xref: EC:2.1.1.80 xref: GO:0008983 xref: MetaCyc:CHER-RXN xref: RESID:AA0072 is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0002316 name: protein-glutamate methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072] subset: gosubset_prok synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61] synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61] synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61] synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61] synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] xref: EC:3.1.1.61 xref: GO:0008984 xref: MetaCyc:MCPMETEST-RXN xref: RESID:AA0072 is_a: CCO:F0008164 ! protein methylesterase activity [Term] id: CCO:F0002317 name: pyruvate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2] subset: gosubset_prok synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.2] synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" EXACT [EC:1.2.2.2] synonym: "pyruvic (cytochrome b1) dehydrogenase activity" EXACT [EC:1.2.2.2] xref: EC:1.2.2.2 xref: GO:0008985 xref: MetaCyc:PYRUVOXID-RXN is_a: CCO:F0001103 ! pyruvate dehydrogenase activity is_a: CCO:F0003224 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: CCO:F0002318 name: pyruvate, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate." [EC:2.7.9.2] subset: gosubset_prok synonym: "ATP:pyruvate, water phosphotransferase activity" EXACT [EC:2.7.9.2] synonym: "PEP synthase activity" EXACT [] synonym: "PEP synthetase activity" EXACT [EC:2.7.9.2] synonym: "phoephoenolpyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvate synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvic synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphopyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate,water dikinase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate-water dikinase (phosphorylating)" EXACT [EC:2.7.9.2] synonym: "water pyruvate dikinase activity" EXACT [] xref: EC:2.7.9.2 xref: GO:0008986 xref: MetaCyc:PEPSYNTH-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003353 ! phosphotransferase activity, paired acceptors [Term] id: CCO:F0002319 name: quinolinate synthetase A activity namespace: molecular_function def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN] subset: gosubset_prok xref: GO:0008987 xref: MetaCyc:QUINOLINATE-SYNTHA-RXN is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0002320 name: rRNA (adenine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [EC:2.1.1.48] subset: gosubset_prok synonym: "ErmC 23S rRNA methyltransferase" NARROW [EC:2.1.1.48] synonym: "gene ksgA methyltransferase" NARROW [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N(6)) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N6) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.48] xref: EC:2.1.1.48 xref: GO:0008988 xref: MetaCyc:RRNA-(ADENINE-N6-)-METHYLTRANSFERASE-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0003155 ! rRNA (adenine) methyltransferase activity [Term] id: CCO:F0002321 name: rRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [EC:2.1.1.51] subset: gosubset_prok synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.51] synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.51] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.51] xref: EC:2.1.1.51 xref: GO:0008989 xref: MetaCyc:RRNA-(GUANINE-N1-)-METHYLTRANSFERASE-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0003157 ! rRNA (guanine) methyltransferase activity [Term] id: CCO:F0002322 name: rRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [EC:2.1.1.52] subset: gosubset_prok synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.52] xref: EC:2.1.1.52 xref: GO:0008990 xref: MetaCyc:RRNA-(GUANINE-N2-)-METHYLTRANSFERASE-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0003157 ! rRNA (guanine) methyltransferase activity [Term] id: CCO:F0002323 name: serine-type signal peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah] xref: EC:3.4.21.- xref: GO:0008991 is_a: CCO:F0000698 ! serine-type endopeptidase activity is_a: CCO:F0002335 ! signal peptidase activity [Term] id: CCO:F0002324 name: repressor LexA activity namespace: molecular_function def: "Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [EC:3.4.21.88] subset: gosubset_prok synonym: "LexA repressor" RELATED [EC:3.4.21.88] synonym: "repressor lexA" RELATED [EC:3.4.21.88] xref: EC:3.4.21.88 xref: GO:0008992 xref: MetaCyc:3.4.21.88-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0002325 name: rhamnulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5] subset: gosubset_prok synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulokinase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "rhamnulokinase (phosphorylating)" EXACT [EC:2.7.1.5] synonym: "rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "RhuK" RELATED [EC:2.7.1.5] xref: EC:2.7.1.5 xref: GO:0008993 xref: MetaCyc:RHAMNULOKIN-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0002326 name: rhamnulose-1-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19] subset: gosubset_prok synonym: "L-rhamnulose 1-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "rhamnulose phosphate aldolase activity" EXACT [EC:4.1.2.19] xref: EC:4.1.2.19 xref: GO:0008994 xref: MetaCyc:RHAMNULPALDOL-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0002327 name: ribonuclease E activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] subset: gosubset_prok xref: GO:0008995 is_a: CCO:F0000934 ! ribonuclease activity [Term] id: CCO:F0002328 name: ribonuclease G activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] subset: gosubset_prok xref: GO:0008996 is_a: CCO:F0000934 ! ribonuclease activity [Term] id: CCO:F0002329 name: ribonuclease R activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193] subset: gosubset_prok xref: EC:3.1.11.- xref: GO:0008997 is_a: CCO:F0000934 ! ribonuclease activity [Term] id: CCO:F0002330 name: ribonucleoside-triphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin." [EC:1.17.4.2] subset: gosubset_prok synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2] xref: EC:1.17.4.2 xref: GO:0008998 xref: MetaCyc:1.17.4.2-RXN is_a: CCO:F0003310 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [Term] id: CCO:F0002331 name: ribosomal-protein-alanine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine." [EC:2.3.1.128] subset: gosubset_prok synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" EXACT [EC:2.3.1.128] synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128] xref: EC:2.3.1.128 xref: GO:0008999 xref: MetaCyc:2.3.1.128-RXN is_a: CCO:F0000978 ! peptide alpha-N-acetyltransferase activity [Term] id: CCO:F0002332 name: selenocysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16] subset: gosubset_prok synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" EXACT [EC:4.4.1.16] synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16] synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16] xref: EC:4.4.1.16 xref: GO:0009000 xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0002333 name: serine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-serine = CoA + O-acetyl-L-serine." [EC:2.3.1.30] subset: gosubset_prok synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "L-serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "SATase activity" EXACT [EC:2.3.1.30] synonym: "serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "serine transacetylase activity" EXACT [EC:2.3.1.30] xref: EC:2.3.1.30 xref: GO:0009001 xref: MetaCyc:SERINE-O-ACETTRAN-RXN is_a: CCO:F0003135 ! serine O-acyltransferase activity is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0002334 name: serine-type D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4] subset: gosubset_prok synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "D-alanyl carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving peptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "DD-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-transpeptidase activity" EXACT [EC:3.4.16.4] xref: EC:3.4.16.4 xref: GO:0009002 xref: MetaCyc:3.4.16.4-RXN is_a: CCO:F0000654 ! serine carboxypeptidase activity [Term] id: CCO:F0002335 name: signal peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah] subset: gosubset_prok xref: GO:0009003 is_a: CCO:F0001783 ! peptidase activity [Term] id: CCO:F0002336 name: signal peptidase I activity namespace: molecular_function def: "Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [EC:3.4.21.89] subset: gosubset_prok synonym: "bacterial leader peptidase 1" RELATED [EC:3.4.21.89] synonym: "bacterial leader peptidase I activity" NARROW [EC:3.4.21.89] synonym: "Escherichia coli leader peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "HOSP" RELATED [EC:3.4.21.89] synonym: "leader peptidase activity" EXACT [EC:3.4.21.89] synonym: "leader peptidase I" RELATED [EC:3.4.21.89] synonym: "leader peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "leader proteinase activity" EXACT [EC:3.4.21.89] synonym: "phage-procoat-leader peptidase activity" NARROW [EC:3.4.21.89] synonym: "pilin leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "propeptidase activity" EXACT [EC:3.4.21.89] synonym: "PuIO prepilin peptidase" NARROW [EC:3.4.21.89] synonym: "signal peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "signal proteinase activity" EXACT [EC:3.4.21.89] synonym: "signalase activity" EXACT [EC:3.4.21.89] synonym: "SPase I activity" EXACT [EC:3.4.21.89] synonym: "SPC" RELATED [EC:3.4.21.89] xref: EC:3.4.21.89 xref: GO:0009004 xref: MetaCyc:3.4.21.89-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity is_a: CCO:F0002335 ! signal peptidase activity [Term] id: CCO:F0002337 name: signal peptidase II activity namespace: molecular_function def: "Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36] subset: gosubset_prok synonym: "leader peptidase II" RELATED [EC:3.4.23.36] synonym: "lipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "premurein leader proteinase activity" EXACT [EC:3.4.23.36] synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36] synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "SPase II activity" EXACT [EC:3.4.23.36] xref: EC:3.4.23.36 xref: GO:0009005 xref: MetaCyc:3.4.23.36-RXN is_a: CCO:F0002375 ! aspartic-type signal peptidase activity [Term] id: CCO:F0002338 name: site-specific DNA-methyltransferase (adenine-specific) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72] subset: gosubset_prok synonym: "DNA adenine methylase" BROAD [] synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72] synonym: "modification methylase activity" RELATED [EC:2.1.1.72] synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72] xref: EC:2.1.1.72 xref: GO:0009007 xref: MetaCyc:2.1.1.72-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity is_a: CCO:F0002339 ! DNA-methyltransferase activity [Term] id: CCO:F0002339 name: DNA-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleate methylase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleate methyltransferase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleic acid methylase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleic acid methyltransferase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleic acid modification methylase activity" RELATED [EC:2.1.1.-] synonym: "DNA methylase" BROAD [] synonym: "DNA methyltransferase activity" EXACT [] synonym: "DNA transmethylase activity" EXACT [EC:2.1.1.-] synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37] xref: EC:2.1.1.- xref: GO:0009008 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0002340 name: site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences." [GOC:elh] comment: Consider also annotating to the molecular function term 'double-stranded DNA binding ; GO:0003690'. Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds. subset: goslim_pir subset: gosubset_prok xref: GO:0009009 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0002341 name: sorbitol-6-phosphate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140] subset: gosubset_prok synonym: "D-glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.140] synonym: "glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "ketosephosphate reductase activity" EXACT [EC:1.1.1.140] synonym: "sorbitol-6-P-dehydrogenase activity" EXACT [EC:1.1.1.140] xref: EC:1.1.1.140 xref: GO:0009010 xref: MetaCyc:SORB6PDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002342 name: starch synthase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21] subset: gosubset_prok synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21] synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21] synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21] synonym: "starch synthetase activity" EXACT [EC:2.4.1.21] xref: EC:2.4.1.21 xref: GO:0009011 xref: MetaCyc:GLYCOGENSYN-RXN is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0002343 name: aminoglycoside 3''-adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + aminoglycoside = diphosphate + 3''-adenylylaminoglycoside." [EC:2.7.7.47, GOC:cb] subset: gosubset_prok synonym: "AAD (3'')" RELATED [EC:2.7.7.47] synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW [] synonym: "streptomycin 3''-adenylyltransferase activity" NARROW [] xref: EC:2.7.7.47 xref: GO:0009012 xref: MetaCyc:STREPTOMYCIN-3 is_a: CCO:F0005512 ! aminoglycoside nucleotidyltransferase activity [Term] id: CCO:F0002344 name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16] subset: gosubset_prok synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.2.1.16] synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.16] xref: EC:1.2.1.16 xref: GO:0009013 xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN xref: UM-BBD_enzymeID:e0020 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002345 name: succinyl-diaminopimelate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate." [EC:3.5.1.18] subset: gosubset_prok synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.18] synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.18] xref: EC:3.5.1.18 xref: GO:0009014 xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0002346 name: N-succinylarginine dihydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N2-succinyl-L-arginine + 2 H2O = N2-succinyl-L-ornithine + 2 NH3 + CO." [EC:3.5.3.23] subset: gosubset_prok synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [EC:3.5.3.23] synonym: "arginine succinylhydrolase activity" EXACT [] synonym: "AruB" RELATED [] synonym: "AstB" RELATED [] synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [] synonym: "N2-succinylarginine dihydrolase activity" EXACT [] synonym: "SADH" RELATED [] synonym: "succinylarginine dihydrolase activity" EXACT [] xref: EC:3.5.3.23 xref: GO:0009015 is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0002347 name: succinyldiaminopimelate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate." [EC:2.6.1.17] subset: gosubset_prok synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.17] synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" EXACT [EC:2.6.1.17] synonym: "succinyldiaminopimelate aminotransferase activity" EXACT [] synonym: "succinyldiaminopimelate transferase activity" EXACT [EC:2.6.1.17] xref: EC:2.6.1.17 xref: GO:0009016 xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0002348 name: succinylglutamate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-glutamate + H2O = succinate + L-glutamate." [EC:3.5.1.96] subset: gosubset_prok synonym: "AstE" RELATED [] synonym: "N-succinyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.96] synonym: "N2-succinylglutamate desuccinylase activity" EXACT [] synonym: "SGDS" RELATED [] xref: EC:3.5.1.96 xref: GO:0009017 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0002349 name: sucrose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [EC:2.4.1.7] subset: gosubset_prok synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7] synonym: "sucrose glucosyltransferase activity" EXACT [EC:2.4.1.7] synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.7] xref: EC:2.4.1.7 xref: GO:0009018 xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0002350 name: tRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "transfer ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "tRNA guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] xref: EC:2.1.1.31 xref: GO:0009019 xref: MetaCyc:TRNA-(GUANINE-N1-)-METHYLTRANSFERASE-RXN is_a: CCO:F0003146 ! tRNA (guanine) methyltransferase activity [Term] id: CCO:F0002351 name: tRNA (guanosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "transfer ribonucleate guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) 2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (guanosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] xref: EC:2.1.1.34 xref: GO:0009020 xref: MetaCyc:2.1.1.34-RXN is_a: CCO:F0003146 ! tRNA (guanine) methyltransferase activity [Term] id: CCO:F0002352 name: tRNA (uracil-5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine." [EC:2.1.1.35] subset: gosubset_prok synonym: "m5U-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "M5U-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35] synonym: "RUMT activity" EXACT [EC:2.1.1.35] synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil methylase activity" EXACT [EC:2.1.1.35] synonym: "tRNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35] xref: EC:2.1.1.35 xref: GO:0009021 xref: MetaCyc:TRNA-(URACIL-5-)-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity is_a: CCO:F0003113 ! tRNA (uracil) methyltransferase activity [Term] id: CCO:F0002353 name: tRNA nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56] subset: gosubset_prok synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56] synonym: "ribonuclease PH activity" EXACT [EC:2.7.7.56] synonym: "RNase PH activity" EXACT [EC:2.7.7.56] synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56] xref: EC:2.7.7.56 xref: GO:0009022 xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002354 name: tagatose-6-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144] subset: gosubset_prok synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.144] synonym: "phosphotagatokinase activity" EXACT [EC:2.7.1.144] xref: EC:2.7.1.144 xref: GO:0009024 xref: MetaCyc:TAGAKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0002355 name: tagatose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.40] subset: gosubset_prok synonym: "AgaY" RELATED [] synonym: "AgaZ" RELATED [] synonym: "D-tagatose-1,6-bisphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT [] synonym: "D-tagatose-1xxx,6-bisphosphate triosephosphate lyase activity" EXACT [EC:4.1.2.40] synonym: "KbaY" RELATED [] synonym: "tagatose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT [] xref: EC:4.1.2.40 xref: GO:0009025 xref: MetaCyc:TAGAALDOL-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0002356 name: tagaturonate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + NADH + H+." [EC:1.1.1.58] subset: gosubset_prok synonym: "altronate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "altronate oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "altronic oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-altronate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-tagaturonate reductase activity" EXACT [EC:1.1.1.58] synonym: "tagaturonate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "TagUAR" RELATED [EC:1.1.1.58] xref: EC:1.1.1.58 xref: GO:0009026 xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002357 name: tartrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93] subset: gosubset_prok synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93] synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93] xref: EC:1.1.1.93 xref: GO:0009027 xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002358 name: tartronate-semialdehyde synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glyoxylate = tartronate semialdehyde + CO2." [EC:4.1.1.47] subset: gosubset_prok synonym: "glyoxalate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.47] synonym: "glyoxylic carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "hydroxymalonic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronate semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] xref: EC:4.1.1.47 xref: GO:0009028 xref: MetaCyc:GLYOCARBOLIG-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0002359 name: tetraacyldisaccharide 4'-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate." [EC:2.7.1.130] subset: gosubset_prok synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" EXACT [EC:2.7.1.130] synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130] xref: EC:2.7.1.130 xref: GO:0009029 xref: MetaCyc:TETRAACYLDISACC4KIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0002360 name: thiamin phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamin phosphate = ADP + thiamin diphosphate." [EC:2.7.4.16] subset: gosubset_prok synonym: "ATP:thiamine-phosphate phosphotransferase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphatase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphokinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin-monophosphate kinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin-phosphate kinase activity" EXACT [] synonym: "thiamine-monophosphate kinase activity" EXACT [EC:2.7.4.16] synonym: "thiamine-phosphate kinase activity" EXACT [] xref: EC:2.7.4.16 xref: GO:0009030 xref: MetaCyc:THI-P-KIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0002361 name: thymidine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [EC:2.4.2.4] subset: gosubset_prok synonym: "animal growth regulators, blood platelet-derived endothelial cell growth factors" RELATED [EC:2.4.2.4] synonym: "blood platelet-derived endothelial cell growth factor" RELATED [EC:2.4.2.4] synonym: "deoxythymidine phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "gliostatins" RELATED [EC:2.4.2.4] synonym: "pyrimidine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4] synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] xref: EC:2.4.2.4 xref: GO:0009032 xref: MetaCyc:THYM-PHOSPH-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0002362 name: trimethylamine-N-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [EC:1.6.6.9] subset: gosubset_prok synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT [EC:1.6.6.9] synonym: "trimethylamine N-oxide reductase" EXACT [EC:1.6.6.9] synonym: "trimethylamine oxidase activity" EXACT [EC:1.6.6.9] synonym: "trimethylamine oxide reductase" EXACT [EC:1.6.6.9] xref: EC:1.6.6.9 xref: GO:0009033 xref: MetaCyc:TMAOREDUCT-RXN is_a: CCO:F0003255 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: CCO:F0002363 name: tryptophanase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + H2O = indole + pyruvate + NH3." [EC:4.1.99.1] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. subset: gosubset_prok synonym: "L-tryptophan indole-lyase (deaminating) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophanase activity" EXACT [EC:4.1.99.1] synonym: "TNase activity" EXACT [EC:4.1.99.1] synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1] synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1] xref: EC:4.1.99.1 xref: GO:0009034 xref: MetaCyc:TRYPDEG-PWY xref: MetaCyc:TRYPTOPHAN-RXN is_a: CCO:F0003397 ! carbon-carbon lyase activity [Term] id: CCO:F0002364 name: Type I site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [EC:3.1.21.3, PMID:15788748] subset: gosubset_prok synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" EXACT [EC:3.1.21.3] synonym: "ATP-dependent DNase activity" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" EXACT [EC:3.1.21.3] synonym: "Type I restriction enzyme activity" EXACT [] synonym: "type I site-specific deoxyribonuclease activity" EXACT [EC:3.1.21.3] xref: EC:3.1.21.3 xref: GO:0009035 xref: MetaCyc:3.1.21.3-RXN is_a: CCO:F0003014 ! restriction endodeoxyribonuclease activity is_a: CCO:F0003446 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002365 name: Type II site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995] subset: gosubset_prok synonym: "Type II restriction enzyme activity" EXACT [] xref: EC:3.1.21.4 xref: GO:0009036 xref: MetaCyc:3.1.21.4-RXN is_a: CCO:F0003014 ! restriction endodeoxyribonuclease activity is_a: CCO:F0003446 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0002366 name: tyrosine-based site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626] subset: gosubset_prok synonym: "site-specific tyrosine recombinase activity" EXACT [] synonym: "tyrosine recombinase" BROAD [] xref: GO:0009037 is_a: CCO:F0002244 ! integrase activity is_a: CCO:F0002340 ! site-specific recombinase activity [Term] id: CCO:F0002367 name: undecaprenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate." [EC:2.7.1.66] subset: gosubset_prok synonym: "ATP:undecaprenol phosphotransferase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenyl alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase (phosphorylating)" EXACT [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66] synonym: "isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66] synonym: "polyisoprenol kinase activity" EXACT [EC:2.7.1.66] xref: EC:2.7.1.66 xref: GO:0009038 xref: MetaCyc:UNDECAPRENOL-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0002368 name: urease activity namespace: molecular_function def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5] subset: gosubset_prok synonym: "urea amidohydrolase activity" EXACT [EC:3.5.1.5] xref: EC:3.5.1.5 xref: GO:0009039 xref: MetaCyc:UREASE-RXN xref: UM-BBD_enzymeID:e0170 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0002369 name: ureidoglycolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate + NADP+ = oxalureate + NADPH + H+." [EC:1.1.1.154] subset: gosubset_prok synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.154] xref: EC:1.1.1.154 xref: GO:0009040 xref: MetaCyc:R165-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002370 name: uridylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators] subset: gosubset_prok xref: EC:2.7.4.- xref: GO:0009041 is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor is_a: CCO:F0004124 ! nucleotide kinase activity [Term] id: CCO:F0002371 name: valine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66] subset: gosubset_prok synonym: "alanine--valine transaminase activity" EXACT [EC:2.6.1.66] synonym: "alanine-oxoisovalerate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "L-valine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "transaminase C activity" NARROW [EC:2.6.1.66] synonym: "valine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "valine-pyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.66 xref: GO:0009042 xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0002372 name: xylan 1,4-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37] subset: gosubset_prok synonym: "1,4-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.37] synonym: "beta-D-xylopyranosidase activity" EXACT [EC:3.2.1.37] synonym: "beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-D-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "xylobiase activity" EXACT [EC:3.2.1.37] xref: EC:3.2.1.37 xref: GO:0009044 xref: MetaCyc:3.2.1.37-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0002373 name: xylose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5] subset: gosubset_prok synonym: "D-xylose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketoisomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketol-isomerase activity" EXACT [EC:5.3.1.5] xref: EC:5.3.1.5 xref: GO:0009045 xref: MetaCyc:XYLISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0002374 name: zinc D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14] synonym: "D-alanyl-D-alanine hydrolase activity" EXACT [EC:3.4.17.14] synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" EXACT [EC:3.4.17.14] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14] synonym: "DD-carboxypeptidase-transpeptidase activity" EXACT [EC:3.4.17.14] synonym: "G enzyme" RELATED [EC:3.4.17.14] synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14] synonym: "Zn2+ G peptidase activity" EXACT [EC:3.4.17.14] xref: EC:3.4.17.14 xref: GO:0009046 xref: MetaCyc:3.4.17.14-RXN is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0002375 name: aspartic-type signal peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah] subset: gosubset_prok xref: EC:3.4.23.- xref: GO:0009049 is_a: CCO:F0000659 ! aspartic-type endopeptidase activity is_a: CCO:F0002335 ! signal peptidase activity [Term] id: CCO:F0002376 name: electron donor activity namespace: molecular_function def: "Any substance that is able to transfer an electron to another chemical species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0009053 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0002377 name: electron acceptor activity namespace: molecular_function def: "Any substance to which an electron may be transferred." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0009054 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0002378 name: electron carrier activity namespace: molecular_function def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: gosubset_prok synonym: "2Fe-2S electron transfer carrier" NARROW [] synonym: "3Fe-4S/4Fe-4S electron transfer carrier" NARROW [] synonym: "adrenodoxin-type ferredoxin" NARROW [] synonym: "amicyanin" NARROW [] synonym: "azurin" NARROW [] synonym: "bacterial-type ferredoxin" NARROW [] synonym: "chloroplast-type ferredoxin" NARROW [] synonym: "copper electron carrier" NARROW [] synonym: "dicluster bacterial-type ferredoxin" NARROW [] synonym: "electron carrier, chlorophyll electron transport system" RELATED [] synonym: "electron transfer flavoprotein" NARROW [] synonym: "electron transfer flavoprotein, group I" NARROW [] synonym: "electron transfer flavoprotein, group II" NARROW [] synonym: "electron transporter activity" EXACT [] synonym: "high-potential iron-sulfur carrier" NARROW [] synonym: "iron-sulfur electron transfer carrier" NARROW [] synonym: "monocluster bacterial-type ferredoxin" NARROW [] synonym: "mononuclear iron electron carrier" NARROW [] synonym: "polyferredoxin" NARROW [] synonym: "redox-active disulfide bond electron carrier" NARROW [] synonym: "rubredoxin" NARROW [] synonym: "small blue copper electron carrier" NARROW [] synonym: "thioredoxin-like 2Fe-2S ferredoxin" NARROW [] xref: GO:0009055 xref: Reactome:20046 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0002379 name: quorum sensing signal generator activity namespace: molecular_function subset: gosubset_prok xref: GO:0009369 is_a: CCO:F0001225 ! signal transducer activity [Term] id: CCO:F0002380 name: quorum sensing response regulator activity namespace: molecular_function subset: gosubset_prok xref: GO:0009370 is_a: CCO:F0001225 ! signal transducer activity [Term] id: CCO:F0002381 name: biotin binding namespace: molecular_function def: "Interacting selectively with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "vitamin B7 binding" EXACT [] synonym: "vitamin H binding" EXACT [] xref: GO:0009374 is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0002382 name: HslUV protease activity namespace: molecular_function def: "A protein complex that possesses ATP-dependent protease activity; as characterized in E. coli, the complex contains six identical subunits of both ClpY and ClpQ that self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, to form a dumbbell shape complex." [GOC:mah, PMID:12670962] subset: gosubset_prok xref: GO:0009377 is_a: CCO:F0001783 ! peptidase activity [Term] id: CCO:F0002383 name: four-way junction helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895] subset: gosubset_prok synonym: "Holliday junction helicase activity" NARROW [] xref: GO:0009378 is_a: CCO:F0000275 ! DNA helicase activity [Term] id: CCO:F0002384 name: excinuclease ABC activity namespace: molecular_function subset: gosubset_prok xref: GO:0009381 is_a: CCO:F0000917 ! endodeoxyribonuclease activity [Term] id: CCO:F0002385 name: rRNA (cytosine-C5-967)-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine, at position 967 in the Escherichia coli small subunit ribosomal RNA or the equivalent position in the small subunit rRNA of other species." [PMID:10026269] comment: Note that the term name mentions a specific position within an E. coli RNA because no other names have yet arisen for this activity; the term nevertheless can be used for analogous activities in other species, and the name can be changed if better wording is found. Synonyms that mention positions applicable to other species may also be added. synonym: "rRNA m5C967 methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: GO:0009383 is_a: CCO:F0001756 ! C-methyltransferase activity is_a: CCO:F0003156 ! rRNA (cytosine) methyltransferase activity [Term] id: CCO:F0002386 name: N-acylmannosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60] subset: gosubset_prok synonym: "acetylamidodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "acylaminodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase (phosphorylating)" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "N-acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "N-acyl-D-mannosamine kinase activity" EXACT [EC:2.7.1.60] xref: EC:2.7.1.60 xref: GO:0009384 xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0002387 name: N-acylmannosamine-6-phosphate 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [MetaCyc:NANE-RXN] synonym: "N-acylmannosamine-6-P epimerase activity" EXACT [] xref: EC:5.-.-.- xref: GO:0009385 xref: MetaCyc:NANE-RXN is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0002388 name: dimethyl sulfoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [UM-BBD_enzymeID:e0188] subset: gosubset_prok synonym: "dimethyl sulphoxide reductase activity" EXACT [] xref: EC:1.8.99.- xref: GO:0009389 xref: UM-BBD_enzymeID:e0188 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0002389 name: ribonucleotide reductase activating enzyme activity namespace: molecular_function xref: EC:1.97.1.- xref: GO:0009391 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0002390 name: N-acetyl-anhydromuramoyl-L-alanine amidase activity namespace: molecular_function xref: GO:0009392 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0002391 name: receptor signaling protein serine/threonine phosphatase activity namespace: molecular_function synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT [] xref: GO:0009400 is_a: CCO:F0001087 ! protein serine/threonine phosphatase activity is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0002392 name: cytochrome bo3 ubiquinol oxidase activity namespace: molecular_function xref: EC:1.10.3.- xref: GO:0009486 is_a: CCO:F0002170 ! cytochrome o ubiquinol oxidase activity [Term] id: CCO:F0002393 name: plastoquinol-plastocyanin reductase activity namespace: molecular_function def: "Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin." [EC:1.10.99.1] subset: gosubset_prok synonym: "cytochrome b6f" NARROW [EC:1.10.99.1] synonym: "plastoquinol/plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] xref: EC:1.10.99.1 xref: GO:0009496 xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003270 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: CCO:F0002394 name: zeaxanthin epoxidase activity namespace: molecular_function def: "Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O." [EC:1.14.13.90] synonym: "zea-epoxidase activity" EXACT [EC:1.14.13.90] synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90] xref: EC:1.14.13.90 xref: GO:0009540 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0002395 name: sucrose:monovalent cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1] synonym: "sucrose permease activity" RELATED [] xref: GO:0009669 is_a: CCO:F0001968 ! sucrose transmembrane transporter activity is_a: CCO:F0002881 ! glycoside-pentoside-hexuronide:cation symporter activity [Term] id: CCO:F0002396 name: triose-phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the exchange of an organic three carbon compound phosphate ester for inorganic phosphate." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-] synonym: "triose phosphate transporter" EXACT [] xref: GO:0009670 xref: GO:0015122 is_a: CCO:F0002622 ! monosaccharide transmembrane transporter activity [Term] id: CCO:F0002397 name: nitrate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [UniProtKB:Q05085] synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT [] synonym: "nitrate(chlorate):proton symporter" EXACT [] xref: GO:0009671 is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0002398 name: auxin:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077] synonym: "auxin:proton symporter" EXACT [] xref: GO:0009672 is_a: CCO:F0002743 ! solute:cation symporter activity [Term] id: CCO:F0002399 name: low affinity phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphate from one side of the membrane to the other. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-] xref: GO:0009673 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity [Term] id: CCO:F0002400 name: potassium:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1] synonym: "high affinity potassium transporter" RELATED [] xref: GO:0009674 is_a: CCO:F0004258 ! potassium ion symporter activity [Term] id: CCO:F0002401 name: high affinity sulfate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). Transporter with a high affinity for sulfate, that mediates the active uptake of sulfate from areas of low sulfate concentration to high sulfate concentration." [UniProtKB:P53391] synonym: "high affinity sulfate:proton symporter" EXACT [] synonym: "high affinity sulphate:hydrogen symporter activity" EXACT [] xref: GO:0009675 is_a: CCO:F0001965 ! sulfate:hydrogen symporter activity [Term] id: CCO:F0002402 name: low affinity sulfate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). Transporter that mediates the transport of sulfate between cellular or subcellular compartments with a low affinity for hydrogen and sulfate." [PMID:7568135] synonym: "low affinity sulfate:proton symporter" EXACT [] synonym: "low affinity sulphate:hydrogen symporter activity" EXACT [] xref: GO:0009676 is_a: CCO:F0001965 ! sulfate:hydrogen symporter activity [Term] id: CCO:F0002403 name: hydrogen-translocating pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.10.-.-] subset: gosubset_prok synonym: "proton-translocating pyrophosphatase activity" EXACT [] xref: GO:0009678 is_a: CCO:F0002826 ! P-P-bond-hydrolysis-driven transmembrane transporter activity is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0002404 name: hexose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-] subset: gosubset_prok synonym: "hexose:proton symporter" EXACT [] xref: GO:0009679 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0002405 name: L-arabinokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate." [EC:2.7.1.46] synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT [] synonym: "L-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.46] xref: EC:2.7.1.46 xref: GO:0009702 xref: MetaCyc:L-ARABINOKINASE-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0002406 name: nitrate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NO2- (nitrite) + NAD+ + H2O = NO3- (nitrate) + NADH + H+." [EC:1.7.1.1] comment: Note that this function was formerly EC:1.6.6.1. synonym: "assimilatory NADH: nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory NADH:nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1] synonym: "NADH-dependent nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH-nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate reductase activity" EXACT [] synonym: "nitrate reductase (NADH(2)) activity" EXACT [EC:1.7.1.1] synonym: "nitrate reductase (NADH2)" EXACT [EC:1.7.1.1] synonym: "nitrite:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.1] xref: EC:1.7.1.1 xref: GO:0009703 xref: MetaCyc:NITRATE-REDUCTASE-(NADH)-RXN is_a: CCO:F0002276 ! nitrate reductase activity is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0002407 name: transmembrane receptor histidine kinase activity namespace: molecular_function def: "A transmembrane receptor that perceives a stimulus and that produces a molecular signal via phosphotransfer at histidine residues." [GOC:lr] subset: gosubset_prok xref: GO:0009784 is_a: CCO:F0001044 ! protein histidine kinase activity is_a: CCO:F0004122 ! transmembrane receptor protein kinase activity [Term] id: CCO:F0002408 name: 1-aminocyclopropane-1-carboxylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ascorbate + 1-aminocyclopropane-1-carboxylate + O2 = 2 H2O + ethene (ethylene) + L-dehydro-ascorbate + hydrocyanic acid + CO2." [EC:1.14.17.4, MetaCyc:ETHYL-RXN] synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" EXACT [EC:1.14.17.4] synonym: "ACC oxidase activity" EXACT [] synonym: "aminocyclopropanecarboxylate oxidase activity" EXACT [EC:1.14.17.4] synonym: "ethene-forming enzyme" BROAD [] synonym: "ethylene-forming enzyme" BROAD [] xref: EC:1.14.17.4 xref: GO:0009815 xref: MetaCyc:ETHYL-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0002409 name: adenylate dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + AMP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-monophosphate." [EC:2.5.1.27] synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT [] synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [EC:2.5.1.27] synonym: "adenylate isopentenyltransferase activity" EXACT [] synonym: "cytokinin synthase activity" EXACT [] synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "isopentenyltransferase activity" EXACT [] xref: EC:2.5.1.27 xref: GO:0009824 xref: MetaCyc:ADENYLATE-ISOPENTENYLTRANSFERASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0002410 name: photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] subset: gosubset_prok synonym: "blue-sensitive opsin" NARROW [] synonym: "green-sensitive opsin" NARROW [] synonym: "long-wave-sensitive opsin" NARROW [] synonym: "opsin" NARROW [] synonym: "red-sensitive opsin" NARROW [] synonym: "short-wave-sensitive opsin" NARROW [] synonym: "UV-sensitive opsin" NARROW [] synonym: "violet-sensitive opsin" NARROW [] xref: GO:0009881 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0002411 name: blue light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb] subset: gosubset_prok xref: GO:0009882 is_a: CCO:F0002410 ! photoreceptor activity [Term] id: CCO:F0002412 name: red or far-red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr] synonym: "red/far-red light photoreceptor activity" EXACT [] xref: GO:0009883 is_a: CCO:F0002410 ! photoreceptor activity [Term] id: CCO:F0002413 name: cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin to initiate a change in cell activity." [GOC:lr] xref: GO:0009884 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0002414 name: transmembrane histidine kinase cytokinin receptor activity namespace: molecular_function def: "A transmembrane receptor of cytokinins that produces a molecular signal via phosphotransfer at histidine residues." [GOC:lr] xref: GO:0009885 is_a: CCO:F0002407 ! transmembrane receptor histidine kinase activity is_a: CCO:F0002413 ! cytokinin receptor activity [Term] id: CCO:F0002415 name: ent-kaurene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaurene + diphosphate." [EC:4.2.3.19, ISBN:0943088399] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.19] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" EXACT [EC:4.2.3.19] synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19] synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19] xref: EC:4.2.3.19 xref: GO:0009899 xref: MetaCyc:4.2.3.19-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0002416 name: ent-copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, ISBN:0943088399] synonym: "diterpene cyclase activity" BROAD [] synonym: "ent-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.13] synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13] synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13] xref: EC:5.5.1.13 xref: GO:0009905 xref: MetaCyc:5.5.1.13-RXN is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0002417 name: alternative oxidase activity namespace: molecular_function def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399] xref: GO:0009916 is_a: CCO:F0003273 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: CCO:F0002418 name: sterol 5-alpha reductase activity namespace: molecular_function def: "Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399] xref: GO:0009917 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0002419 name: sterol delta7 reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399] synonym: "sterol delta-7 reductase activity" EXACT [] xref: GO:0009918 xref: MetaCyc:RXN-707 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0002420 name: fatty acid elongase activity namespace: molecular_function def: "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] xref: GO:0009922 is_a: CCO:F0000733 ! fatty-acid synthase activity [Term] id: CCO:F0002421 name: octadecanal decarbonylase activity namespace: molecular_function def: "Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb] synonym: "aldehyde decarbonylase activity" EXACT [] synonym: "decarbonylase activity" EXACT [EC:4.1.99.5] synonym: "octadecanal alkane-lyase activity" EXACT [] xref: EC:4.1.99.5 xref: GO:0009924 xref: MetaCyc:OCTADECANAL-DECARBONYLASE-RXN is_a: CCO:F0003397 ! carbon-carbon lyase activity [Term] id: CCO:F0002422 name: histidine phosphotransfer kinase activity namespace: molecular_function def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140] subset: gosubset_prok xref: GO:0009927 is_a: CCO:F0001225 ! signal transducer activity is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0002423 name: calcium-dependent protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium ions." [GOC:mah] xref: GO:0009931 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0002424 name: amino-terminal vacuolar sorting propeptide binding namespace: molecular_function def: "Interacting selectively with an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin coated vesicles." [GOC:sm, PMID:10871276] xref: GO:0009940 is_a: CCO:F0002447 ! vacuolar sorting signal binding [Term] id: CCO:F0002425 name: adenylyl-sulfate reductase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + SO3(2-) (sulfite) + acceptor = adenylyl sulfate + reduced acceptor." [EC:1.8.99.2, PMID:5421934] subset: gosubset_prok synonym: "adenosine 5'-phosphosulfate reductase" EXACT [EC:1.8.99.2] synonym: "adenosine phosphosulfate reductase activity" EXACT [EC:1.8.99.2] synonym: "adenylyl-sulphate reductase activity" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "APS reductase activity" EXACT [EC:1.8.99.2] synonym: "APS-reductase" EXACT [EC:1.8.99.2] xref: EC:1.8.99.2 xref: GO:0009973 xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0002426 name: epsilon hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of zeinoxanthin to lutein. Adds hydroxy group to the epsilon ring of the alpha-carotene." [PMID:8837513] xref: GO:0009974 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0002427 name: cyclase activity namespace: molecular_function def: "Catalysis of a ring closure reaction." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok xref: GO:0009975 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0002428 name: tocopherol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)." [PMID:12213958] xref: GO:0009976 is_a: CCO:F0002427 ! cyclase activity [Term] id: CCO:F0002429 name: proton motive force dependent protein transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of proteins from one side of the membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245] synonym: "delta-pH-dependent protein transporter activity" EXACT [] synonym: "pH-dependent protein transporter activity" EXACT [] xref: GO:0009977 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity is_a: CCO:F0002860 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: CCO:F0002430 name: allene oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] synonym: "HPI" RELATED [EC:4.2.1.92] synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] xref: GO:0009978 xref: MetaCyc:RXN1F-19 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0002431 name: 16:0 monogalactosyldiacylglycerol desaturase activity namespace: molecular_function xref: GO:0009979 is_a: CCO:F0005667 ! omega-3 fatty acid desaturase activity [Term] id: CCO:F0002432 name: glutamate carboxypeptidase activity namespace: molecular_function def: "Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN] subset: gosubset_prok synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11] synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11] synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11] synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11] synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11] xref: EC:3.4.17.11 xref: GO:0009980 xref: MetaCyc:3.4.17.11-RXN is_a: CCO:F0000649 ! carboxypeptidase activity [Term] id: CCO:F0002433 name: pseudouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. subset: gosubset_prok xref: EC:5.4.99.- xref: GO:0009982 is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0002434 name: tyrosine aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0009983 is_a: CCO:F0000646 ! aminopeptidase activity [Term] id: CCO:F0002435 name: dihydroflavonol(thiole) lyase activity namespace: molecular_function xref: GO:0009985 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0002436 name: auxin binding namespace: molecular_function def: "Interacting selectively with auxin, plant hormones that regulate aspects of plant growth." [GOC:sm] synonym: "auxin receptor" NARROW [] xref: GO:0010011 is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0002437 name: steroid 22-alpha hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb] xref: GO:0010012 is_a: CCO:F0001866 ! steroid hydroxylase activity [Term] id: CCO:F0002438 name: N-1-naphthylphthalamic acid binding namespace: molecular_function def: "Interacting selectively with N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm] xref: GO:0010013 is_a: CCO:F0001746 ! drug binding [Term] id: CCO:F0002439 name: nucleoside transmembrane transporter activity, against a concentration gradient namespace: molecular_function def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb] synonym: "concentrative nucleoside transporter" EXACT [] xref: GO:0010174 is_a: CCO:F0001567 ! nucleoside transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002440 name: sphingosine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of amino alcohol sphingosine from one side of the membrane to the other." [GOC:tb] xref: GO:0010175 is_a: CCO:F0001958 ! monoamine transmembrane transporter activity is_a: CCO:F0003013 ! alcohol transmembrane transporter activity [Term] id: CCO:F0002441 name: homogentisate phytyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + phytyl diphosphate -> 2-methyl-6-phytylplastoquinol." [PMID:14512521] xref: GO:0010176 is_a: CCO:F0002489 ! homogentisate prenyltransferase activity [Term] id: CCO:F0002442 name: methylthioalkylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: w-methylthio-2-oxoalkanoic acid + acetyl-CoA + H2O = 2-(w-methylthio)alkylmalate + CoA." [GOC:pz] xref: GO:0010177 is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0002443 name: IAA-amino acid conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb] xref: GO:0010178 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0002444 name: IAA-Ala conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IAA-alanine -> indole-3-acetic acid + alanine." [GOC:tb] xref: GO:0010179 is_a: CCO:F0002443 ! IAA-amino acid conjugate hydrolase activity [Term] id: CCO:F0002445 name: thioglucosidase binding activity namespace: molecular_function def: "Interacting selectively with the enzyme thioglucosidase." [GOC:tb] synonym: "myrosinase binding activity" EXACT [] xref: GO:0010180 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0002446 name: FMN binding namespace: molecular_function def: "Interacting selectively with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] subset: gosubset_prok synonym: "flavin mononucleotide binding" EXACT [] xref: GO:0010181 is_a: CCO:F0000031 ! nucleotide binding is_a: CCO:F0007988 ! coenzyme binding [Term] id: CCO:F0002447 name: vacuolar sorting signal binding namespace: molecular_function def: "Interacting selectively with a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah] xref: GO:0010209 is_a: CCO:F0001368 ! signal sequence binding [Term] id: CCO:F0002448 name: IAA-Phe conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IAA-phenylalanine -> indole-3-acetic acid + phenylalanine." [GOC:syr] xref: GO:0010210 is_a: CCO:F0002443 ! IAA-amino acid conjugate hydrolase activity [Term] id: CCO:F0002449 name: IAA-Leu conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IAA-leucine -> indole-3-acetic acid + leucine." [GOC:syr] xref: GO:0010211 is_a: CCO:F0002443 ! IAA-amino acid conjugate hydrolase activity [Term] id: CCO:F0002450 name: ent-kaurene oxidase activity namespace: molecular_function def: "Catalysis of three successive oxidations of the 4-methyl group of ent-kaurene resulting in kaurenoic acid." [GOC:tb] synonym: "ent-kaur-16-ene,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [] xref: EC:1.14.13.78 xref: GO:0010241 xref: MetaCyc:1.14.13.78-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0002451 name: oxygen evolving activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862] synonym: "photosynthetic water oxidation" EXACT [] xref: GO:0010242 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0002452 name: phytol kinase activity namespace: molecular_function def: "Catalysis of the reaction: phytol + CTP = phytylphosphate + CDP." [PMID:16361393] xref: GO:0010276 is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0002453 name: chlorophyllide a oxygenase activity namespace: molecular_function def: "Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+." [EC:1.13.12.14, MetaCyc:RXN-7677] synonym: "CAO" RELATED [EC:1.13.12.14] synonym: "chlorophyll a oxygenase activity" EXACT [] synonym: "chlorophyll b synthetase activity" EXACT [] synonym: "chlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14] synonym: "cholorophyll-b synthase activity" EXACT [EC:1.13.12.14] xref: EC:1.13.12.14 xref: GO:0010277 xref: GO:0046407 is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: CCO:F0002454 name: indole-3-acetic acid amido synthetase namespace: molecular_function def: "Catalysis of the reaction IAA + an amino acid = an IAA amide conjugate." [PMID:15659623] synonym: "IAA amido synthetase activity" EXACT [] xref: GO:0010279 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0002455 name: UDP-L-rhamnose synthase activity namespace: molecular_function def: "Catalysis of the reaction UDP-D-glucose + NADPH = UDP-L-rhamnose + NADP+ + H2O." [GOC:tair_curators, PMID:14701918] synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" EXACT [] xref: GO:0010280 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0002456 name: pinoresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: pinoresinol + NADPH = lariciresinol + NADP+." [PMID:10066819, PMID:7592828] xref: GO:0010283 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002457 name: lariciresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: lariciresinol + NADPH = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828] xref: GO:0010284 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002458 name: L,L-diaminopimelate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O." [PMID:16361515] synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [] synonym: "LL-DAP aminotransferase activity" EXACT [EC:2.6.1.83] synonym: "LL-DAP-AT activity" EXACT [EC:2.6.1.83] synonym: "LL-diaminopimelate aminotransferase activity" EXACT [] synonym: "LL-diaminopimelate transaminase activity" EXACT [EC:2.6.1.83] xref: EC:2.6.1.83 xref: GO:0010285 xref: GO:0043742 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0002459 name: chlorophyll catabolite transporter activity namespace: molecular_function def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), into, out of, within or between cells." [PMID:9681016] xref: GO:0010290 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0002460 name: carotene beta-ring hydroxylase activity namespace: molecular_function def: "Catalysis of C3-hydroxylation reaction of the beta-ring of various carotenes." [PMID:16492736] xref: GO:0010291 is_a: CCO:F0000894 ! monooxygenase activity [Term] id: CCO:F0002461 name: GTP:GDP antiporter activity namespace: molecular_function def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903] xref: GO:0010292 is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0002462 name: abscisic aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: abscisic aldehyde + H2O + O2 = abscisate + H2O2." [EC:1.2.3.14, PMID:11050171] synonym: "AAO3" RELATED [EC:1.2.3.14] synonym: "abscisic-aldehyde oxidase activity" EXACT [EC:1.2.3.14] synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.14] synonym: "AOdelta" RELATED [EC:1.2.3.14] xref: EC:1.2.3.14 xref: GO:0010293 xref: GO:0033725 is_a: CCO:F0003685 ! aryl-aldehyde oxidase activity [Term] id: CCO:F0002463 name: abscisic acid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ABA + UDP-D-glucose = ABA-glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062] xref: GO:0010294 xref: MetaCyc:PWY-5272 is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0002465 name: prenylcysteine methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein prenyl L-cysteine methylester + H2O = protein L-cysteine + methanol." [PMID:16870359] xref: GO:0010296 is_a: CCO:F0008164 ! protein methylesterase activity [Term] id: CCO:F0002466 name: heteroglycan binding namespace: molecular_function def: "Interacting selectively with heteroglycans." [PMID:16640603] xref: GO:0010297 is_a: CCO:F0004357 ! polysaccharide binding [Term] id: CCO:F0002467 name: dihydrocamalexic acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2." [PMID:16766671] xref: GO:0010298 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0002468 name: xanthoxin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: xanthoxin + NAD+ = abscisic aldehyde + NADH + H+." [EC:1.1.1.288, PMID:12172025] synonym: "ABA2" RELATED [EC:1.1.1.288] synonym: "xanthoxin oxidase activity" EXACT [EC:1.1.1.288] synonym: "xanthoxin:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.288] xref: EC:1.1.1.288 xref: GO:0010301 xref: GO:0033710 is_a: CCO:F0000500 ! alcohol dehydrogenase activity [Term] id: CCO:F0002469 name: 2-oxoglutarate-dependent dioxygenase activity namespace: molecular_function def: "Hydroxylase, with 2-oxoglutarate as one donor, and incorporation or reduction of one atom each of oxygen into both donors." [EC:1.14.11.-, PMID:16140259] xref: GO:0010302 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0002470 name: limit dextrinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (16)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142] synonym: "amylopectin-1,6-glucosidase activity" EXACT [EC:3.2.1.142] synonym: "dextrin alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.142] synonym: "R-enzyme" RELATED [EC:3.2.1.142] xref: EC:3.2.1.142 xref: GO:0010303 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0002471 name: acetylglutamate kinase regulator activity namespace: molecular_function def: "Modulates the enzyme activity of acetylglutamate kinase." [PMID:16377628] xref: GO:0010307 is_a: CCO:F0004130 ! kinase regulator activity [Term] id: CCO:F0002472 name: acireductone dioxygenase (Ni2+-requiring) activity namespace: molecular_function def: "Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + formate + CO." [EC:1.13.11.53, PMID:16297065] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" EXACT [EC:1.13.11.53] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "ARD activity" RELATED [EC:1.13.11.53] synonym: "E-2 activity" RELATED [EC:1.13.11.53] xref: EC:1.13.11.53 xref: GO:0010308 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0002473 name: acireductone dioxygenase [iron(II)-requiring] activity namespace: molecular_function def: "Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate." [EC:1.13.11.54, PMID:16297065] subset: gosubset_prok synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT [] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" EXACT [EC:1.13.11.54] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD [] synonym: "aci-reductone dioxygenase" BROAD [] synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT [] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54] synonym: "ARD'" RELATED [] synonym: "ARD1" RELATED [] synonym: "E-2'" RELATED [] xref: EC:1.13.11.54 xref: GO:0010309 xref: MetaCyc:R147-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0002474 name: phytochrome binding namespace: molecular_function def: "Interacting selectively with phytochrome." [PMID:15486102] xref: GO:0010313 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0002475 name: phosphatidylinositol-5-phosphate binding namespace: molecular_function def: "Interacting selectively with phosphatidylinositol-5-phosphate, a phosphorylated derivative of phosphatidylinositol." [GOC:tair_curators] xref: GO:0010314 is_a: CCO:F0005562 ! phosphoinositide binding [Term] id: CCO:F0002476 name: arginine/lysine endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators] xref: GO:0010320 is_a: CCO:F0000644 ! endopeptidase activity [Term] id: CCO:F0002477 name: methionine-oxo-acid transaminase activity namespace: molecular_function def: "Catalyzes the reaction: methionine + a 2-oxo acid = 4-methylthio-2-oxobutyrate + an amino acid." [PMID:17056707] xref: GO:0010326 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0002478 name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity namespace: molecular_function def: "Catalyzes the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883] synonym: "hexenol acetyltransferase" RELATED [] xref: GO:0010327 is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0002479 name: auxin influx transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804] synonym: "auxin influx facilitator" RELATED [] xref: GO:0010328 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0002480 name: auxin efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804] synonym: "auxin efflux carrier" RELATED [] synonym: "auxin efflux facilitator" RELATED [] xref: GO:0010329 is_a: CCO:F0002942 ! efflux transmembrane transporter activity is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0002481 name: gibberellin binding activity namespace: molecular_function def: "Interacting selectively with gibberellins, plant hormones that regulate aspects of plant growth." [GOC:tair_curators] synonym: "gibberellic acid receptor" RELATED [] synonym: "gibberellin receptor" RELATED [] xref: GO:0010331 is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0002482 name: terpene synthase activity namespace: molecular_function def: "Catalyzing the formation of cyclic terpenes through the cyclization of linear terpenes containing varying quantities of isoprene units (i.e. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP)." [EC:4.2.3., GOC:tair_curators] xref: GO:0010333 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0002483 name: sesquiterpene synthase activity namespace: molecular_function def: "Catalyzing the formation of sesquiterpenes (terpene containing 15 carbons, i.e. three isoprene units) through the cyclization of trans,trans-farnesyl diphosphate (an allylic prenyl diphosphate intermediates of the terpene biosynthesis pathway)." [EC:4.2.3.-, GOC:tair_curators] xref: GO:0010334 is_a: CCO:F0002482 ! terpene synthase activity [Term] id: CCO:F0002484 name: carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201] xref: GO:0010340 is_a: CCO:F0001758 ! O-methyltransferase activity [Term] id: CCO:F0002485 name: gibberellin carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + GA = S-adenosyl-L-homocysteine + GA methyl ester." [PMID:17220201] xref: GO:0010341 is_a: CCO:F0002484 ! carboxyl-O-methyltransferase activity [Term] id: CCO:F0002486 name: L-galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667] xref: GO:0010347 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0002487 name: lithium:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011] xref: GO:0010348 is_a: CCO:F0001614 ! monovalent cation:proton antiporter activity [Term] id: CCO:F0002488 name: L-galactose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629] synonym: "L-galactose 1-dehydrogenase activity" RELATED [] xref: GO:0010349 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002489 name: homogentisate prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822] xref: GO:0010354 is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0002490 name: homogentisate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate -> 2-methyl-6-farnesylplastoquinol." [PMID:16989822] xref: GO:0010355 is_a: CCO:F0002489 ! homogentisate prenyltransferase activity [Term] id: CCO:F0002491 name: homogentisate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate -> 2-methyl-6-geranylgeranylplastoquinol." [PMID:16989822] xref: GO:0010356 is_a: CCO:F0002489 ! homogentisate prenyltransferase activity [Term] id: CCO:F0002492 name: homogentisate solanesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + solanesyl diphosphate -> 2-methyl-6-solanesylplastoquinol." [PMID:16989822] xref: GO:0010357 is_a: CCO:F0002489 ! homogentisate prenyltransferase activity [Term] id: CCO:F0002493 name: double-stranded methylated DNA binding namespace: molecular_function def: "Interacting selectively with double-stranded methylated DNA. Cytosine methylation in DNA is an important mechanism for establishing stable heritable epigenetic marks." [PMID:17242155] xref: GO:0010385 is_a: CCO:F0000282 ! double-stranded DNA binding [Term] id: CCO:F0002494 name: polyprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate (or 3-polyprenyl-5-hydroxy-4-methoxybenzoate)." [PMID:9628017] xref: GO:0010420 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0002495 name: abscisic acid binding activity namespace: molecular_function def: "Interacting selectively with abscisic acid, plant hormones that regulate aspects of plant growth." [PMID:17347412] synonym: "ABA binding activity" RELATED [] synonym: "abscisate binding activity" RELATED [] xref: GO:0010427 is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0002496 name: methyl-CpNpG binding namespace: molecular_function def: "Interacting selectively with a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600] xref: GO:0010428 is_a: CCO:F0000031 ! nucleotide binding [Term] id: CCO:F0002497 name: methyl-CpNpN binding namespace: molecular_function def: "Interacting selectively with a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600] xref: GO:0010429 is_a: CCO:F0000031 ! nucleotide binding [Term] id: CCO:F0002498 name: 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid (OPC-8:0) + CoA = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)- cyclopentane-1-octanoyl-CoA." [PMID:16963437] synonym: "OPC-8:0 CoA ligase activity" RELATED [] xref: GO:0010435 is_a: CCO:F0003128 ! CoA-ligase activity [Term] id: CCO:F0002499 name: carotenoid dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333] synonym: "carotenoid-cleaving dioxygenase" RELATED [] xref: GO:0010436 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0002500 name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333] xref: GO:0010437 is_a: CCO:F0002499 ! carotenoid dioxygenase activity [Term] id: CCO:F0002501 name: light-activated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb] xref: GO:0010461 is_a: CCO:F0001492 ! ion channel activity [Term] id: CCO:F0002502 name: nerve growth factor receptor activity namespace: molecular_function def: "Combining with nerve growth factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb] xref: GO:0010465 is_a: CCO:F0001357 ! neurotrophin receptor activity [Term] id: CCO:F0002503 name: GDP-galactose:mannose-1-phosphate guanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-galactose-1-phosphate + mannose-1-phosphate = galactose-1-phosphate + GDP-mannose." [PMID:17485667] xref: GO:0010471 is_a: CCO:F0002242 ! mannose-phosphate guanylyltransferase activity [Term] id: CCO:F0002504 name: GDP-galactose:glucose-1-phosphate guanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-galactose-1-phosphate + glucose-1-phosphate = galactose-1-phosphate + GDP-glucose." [PMID:17485667] xref: GO:0010472 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002505 name: GDP-galactose:myoinositol-1-phosphate guanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-galactose-1-phosphate + myoinositol-1-phosphate = galactose-1-phosphate + GDP-myoinositol." [PMID:17485667] xref: GO:0010473 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002506 name: glucose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose." [PMID:17462988] synonym: "GDP:Glucose-1- phosphate guanyltransferase activity " EXACT [] xref: GO:0010474 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002507 name: galactose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose." [PMID:17462988] xref: GO:0010475 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0002508 name: H3 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H3." [PMID:17877703] xref: GO:0010484 is_a: CCO:F0000815 ! H3/H4 histone acetyltransferase activity [Term] id: CCO:F0002509 name: H4 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H4." [PMID:17877703] xref: GO:0010485 is_a: CCO:F0000815 ! H3/H4 histone acetyltransferase activity [Term] id: CCO:F0002510 name: manganese:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518] xref: GO:0010486 is_a: CCO:F0008064 ! metal ion:hydrogen antiporter activity [Term] id: CCO:F0002511 name: thermospermine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + thermospermine." [PMID:17560575] xref: GO:0010487 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0002512 name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273] xref: GO:0010488 is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0002513 name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose -> UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829] xref: GO:0010489 is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0002514 name: UDP-4-keto-rhamnose-4-keto-reductase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH -> UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829] xref: GO:0010490 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002515 name: UTP:arabinose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835] xref: GO:0010491 is_a: CCO:F0008184 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: CCO:F0002516 name: telomerase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:dph, GOC:krc, GOC:tb] xref: GO:0010521 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0002517 name: Hsp27 protein regulator activity namespace: molecular_function def: "Modulates the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb, PMID:11546764] xref: GO:0010538 is_a: CCO:F0004341 ! chaperone regulator activity [Term] id: CCO:F0002518 name: Hsp27 protein inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb] xref: GO:0010539 is_a: CCO:F0002517 ! Hsp27 protein regulator activity is_a: CCO:F0004343 ! chaperone inhibitor activity [Term] id: CCO:F0002519 name: nitrate efflux transmembrane transporter activity namespace: molecular_function xref: GO:0010542 is_a: CCO:F0002591 ! nitrite transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity is_a: CCO:F0002942 ! efflux transmembrane transporter activity [Term] id: CCO:F0002520 name: Hsp90 protein regulator activity namespace: molecular_function def: "Binds to and modulates the activity of the molecular chaperone Hsp90." [GOC:dph, GOC:tb, PMID:11146632] xref: GO:0010545 is_a: CCO:F0004341 ! chaperone regulator activity is_a: CCO:F0008202 ! Hsp90 protein binding [Term] id: CCO:F0002521 name: Hsp90 protein inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the Hsp90 molecular chaperone." [GOC:dph, GOC:tb, PMID:11146632] xref: GO:0010546 is_a: CCO:F0002520 ! Hsp90 protein regulator activity is_a: CCO:F0004343 ! chaperone inhibitor activity [Term] id: CCO:F0002522 name: heme-copper terminal oxidase activity namespace: molecular_function def: "Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd] subset: gosubset_prok synonym: "haem-copper terminal oxidase activity" EXACT [] xref: GO:0015002 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0002524 name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135] synonym: "glucuronosyltransferase I activity" NARROW [EC:2.4.1.135] synonym: "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] synonym: "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] synonym: "uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity" EXACT [EC:2.4.1.135] xref: EC:2.4.1.135 xref: GO:0015018 xref: MetaCyc:2.4.1.135-RXN is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0002525 name: heparan-alpha-glucosaminide N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide." [EC:2.3.1.78] synonym: "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] synonym: "acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] xref: EC:2.3.1.78 xref: GO:0015019 xref: MetaCyc:2.3.1.78-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0002526 name: glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] synonym: "1-naphthol glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "1-naphthol-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "17-OH steroid UDPGT activity" NARROW [EC:2.4.1.17] synonym: "17beta-hydroxysteroid UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "3-OH androgenic UDPGT activity" NARROW [EC:2.4.1.17] synonym: "3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-nitrophenol UDPGT activity" NARROW [EC:2.4.1.17] synonym: "bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin monoglucuronide glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin UDPGT activity" NARROW [EC:2.4.1.17] synonym: "bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "ciramadol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "estriol UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "estrone UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "GT activity" EXACT [EC:2.4.1.17] synonym: "morphine glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenylglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-phenylphenol glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "phenyl-UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "Phenyl-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "PNP-UDPGT" RELATED [EC:2.4.1.17] synonym: "pnp-UDPGT activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronic acid transferase activity" EXACT [EC:2.4.1.17] synonym: "UDP glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDPGA transferase activity" EXACT [EC:2.4.1.17] synonym: "UDPGA-glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" EXACT [EC:2.4.1.17] synonym: "UDPGT activity" EXACT [EC:2.4.1.17] synonym: "uridine 5'-diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphate glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] xref: EC:2.4.1.17 xref: GO:0003981 xref: GO:0015020 xref: MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN xref: Reactome:9978 is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0002527 name: heparin-sulfate lyase activity namespace: molecular_function def: "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar." [EC:4.2.2.8] subset: gosubset_prok synonym: "heparin-sulfate eliminase activity" RELATED [EC:4.2.2.8] synonym: "heparin-sulphate lyase activity" EXACT [] synonym: "heparitin-sulfate lyase activity" EXACT [] synonym: "heparitinase I" RELATED [EC:4.2.2.8] synonym: "heparitinase II" RELATED [EC:4.2.2.8] xref: EC:4.2.2.8 xref: GO:0015021 xref: MetaCyc:4.2.2.8-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0002528 name: glucuronate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate." [EC:3.1.6.18] synonym: "chondro-2-sulfatase activity" EXACT [EC:3.1.6.18] synonym: "glucuronate-2-sulphatase activity" EXACT [] synonym: "glucurono-2-sulfatase activity" EXACT [EC:3.1.6.18] synonym: "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity" EXACT [EC:3.1.6.18] xref: EC:3.1.6.18 xref: GO:0015024 xref: MetaCyc:3.1.6.18-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0002529 name: coreceptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators] xref: GO:0015026 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0002530 name: coreceptor, soluble ligand activity namespace: molecular_function xref: GO:0015027 is_a: CCO:F0002529 ! coreceptor activity [Term] id: CCO:F0002531 name: coreceptor, insoluble ligand activity namespace: molecular_function xref: GO:0015028 is_a: CCO:F0002529 ! coreceptor activity [Term] id: CCO:F0002532 name: protein disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN-] subset: gosubset_prok synonym: "protein disulphide oxidoreductase activity" EXACT [] xref: GO:0015035 xref: MetaCyc:DISULFOXRED-RXN is_a: CCO:F0002533 ! disulfide oxidoreductase activity [Term] id: CCO:F0002533 name: disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction that interconverts reduced sulfide groups and oxidized disulfide bonds in a substrate." [GOC:mah, MetaCyc:DISULFOXRED-RXN] subset: gosubset_prok synonym: "disulphide oxidoreductase activity" EXACT [] xref: GO:0015036 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0002534 name: peptide disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds." [GOC:mah, MetaCyc:DISULFOXRED-RXN-] subset: gosubset_prok synonym: "peptide disulphide oxidoreductase activity" EXACT [] xref: GO:0015037 is_a: CCO:F0002533 ! disulfide oxidoreductase activity [Term] id: CCO:F0002535 name: glutathione disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah] subset: gosubset_prok synonym: "glutaredoxin" RELATED [] synonym: "glutathione disulphide oxidoreductase activity" EXACT [] xref: GO:0015038 is_a: CCO:F0002534 ! peptide disulfide oxidoreductase activity [Term] id: CCO:F0002536 name: NADPH-adrenodoxin reductase activity namespace: molecular_function def: "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+." [EC:1.18.1.2, GOC:kd] comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'. synonym: "adrenodoxin reductase activity" BROAD [EC:1.18.1.2] synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd] synonym: "NADPH:adrenodoxin oxidoreductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.- xref: GO:0015039 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0002537 name: trypanothione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide." [EC:1.8.1.12] comment: Note that this function was formerly EC:1.6.4.8. synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] synonym: "N1,N8-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] synonym: "NADPH2:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] synonym: "NADPH:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] synonym: "trypanothione reductase activity" EXACT [] synonym: "trypanothione-disulphide reductase activity" EXACT [] synonym: "trypanothione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.12] xref: EC:1.8.1.12 xref: GO:0015042 xref: MetaCyc:1.8.1.12-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0002538 name: leghemoglobin reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin." [EC:1.6.2.6] synonym: "ferric leghemoglobin reductase activity" EXACT [EC:1.6.2.6] synonym: "NAD(P)H:ferrileghemoglobin oxidoreductase activity" EXACT [EC:1.6.2.6] xref: EC:1.6.2.6 xref: GO:0015043 xref: MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003251 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: CCO:F0002539 name: rubredoxin-NAD+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1] subset: gosubset_prok synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "DPNH-rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "NADH--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] synonym: "NADH--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "NADH:rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] synonym: "NADH:rubredoxin reductase activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin--NAD reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.1] xref: EC:1.18.1.1 xref: GO:0015044 xref: MetaCyc:RUBREDOXIN--NAD(+)-REDUCTASE-RXN is_a: CCO:F0002541 ! rubredoxin reductase activity [Term] id: CCO:F0002540 name: rubredoxin-NAD(P)+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.4] synonym: "dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.4] synonym: "NAD(P)--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] synonym: "NAD(P)H--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] synonym: "NADPH:rubredoxin reductase activity" EXACT [] synonym: "rubredoxin--nicotinamide adenine activity" RELATED [EC:1.18.1.4] synonym: "rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity" EXACT [EC:1.18.1.4] synonym: "rubredoxin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.18.1.4] xref: EC:1.18.1.4 xref: GO:0015045 xref: MetaCyc:RUBREDOXIN--NADP(+)-REDUCTASE-RXN is_a: CCO:F0002541 ! rubredoxin reductase activity [Term] id: CCO:F0002541 name: rubredoxin reductase activity namespace: molecular_function def: "Catalysis of the reactions: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.-] subset: gosubset_prok xref: EC:1.18.1.- xref: GO:0015046 is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003312 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: CCO:F0002542 name: NADPH-cytochrome-c2 reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2." [EC:1.6.2.5] synonym: "cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)" EXACT [EC:1.6.2.5] synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" EXACT [EC:1.6.2.5] synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.6.2.5] xref: EC:1.6.2.5 xref: GO:0015047 xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN is_a: CCO:F0003251 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: CCO:F0002543 name: phthalate dioxygenase reductase activity namespace: molecular_function def: "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems." [PMID:7589982] xref: GO:0015048 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0002544 name: methane monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O." [EC:1.14.13.25] subset: gosubset_prok synonym: "methane hydroxylase activity" EXACT [EC:1.14.13.25] synonym: "methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.25] xref: EC:1.14.13.25 xref: GO:0015049 xref: MetaCyc:METHANE-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0007 is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0002545 name: X-opioid receptor activity namespace: molecular_function xref: GO:0015051 is_a: CCO:F0001323 ! opioid receptor activity [Term] id: CCO:F0002546 name: beta3-adrenergic receptor activity namespace: molecular_function synonym: "beta3 adrenoceptor" EXACT [] xref: GO:0015052 is_a: CCO:F0001281 ! beta-adrenergic receptor activity [Term] id: CCO:F0002547 name: gastrin receptor activity namespace: molecular_function def: "Combining with gastrin to initiate a change in cell activity." [GOC:ai] synonym: "cholecystokinin-B receptor activity" EXACT [] xref: GO:0015054 is_a: CCO:F0001293 ! cholecystokinin receptor activity [Term] id: CCO:F0002548 name: secretin receptor activity namespace: molecular_function def: "Combining with secretin to initiate a change in cell activity." [GOC:mah] xref: GO:0015055 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0002549 name: corticotrophin-releasing factor receptor activity namespace: molecular_function def: "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity." [PMID:12032352] xref: GO:0015056 is_a: CCO:F0000186 ! corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity [Term] id: CCO:F0002550 name: thrombin receptor activity namespace: molecular_function def: "Combining with thrombin to initiate a change in cell activity." [GOC:ai] xref: GO:0015057 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0002551 name: epidermal growth factor-like module containing hormone receptor activity namespace: molecular_function synonym: "EGF-like module containing hormone receptor activity" EXACT [] synonym: "Egr1 hormone receptor" EXACT [] xref: GO:0015058 xref: GO:0016523 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0002552 name: uridine nucleotide receptor activity namespace: molecular_function def: "Combining with UTP or UDP to initiate a change in cell activity." [UniProtKB:P51582] synonym: "purinoceptor type U" EXACT [] xref: GO:0015065 is_a: CCO:F0006063 ! purinergic nucleotide receptor activity, G-protein coupled [Term] id: CCO:F0002553 name: alpha-amylase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of alpha-amylase." [GOC:mah] subset: gosubset_prok xref: GO:0015066 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0002554 name: amidinotransferase activity namespace: molecular_function def: "Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai] subset: gosubset_prok synonym: "transamidinase activity" EXACT [] xref: EC:2.1.4.- xref: GO:0015067 is_a: CCO:F0003317 ! transferase activity, transferring one-carbon groups is_a: CCO:F0003342 ! transferase activity, transferring nitrogenous groups [Term] id: CCO:F0002555 name: glycine amidinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate." [EC:2.1.4.1] subset: gosubset_prok synonym: "arginine-glycine amidinotransferase activity" EXACT [EC:2.1.4.1] synonym: "arginine-glycine transamidinase activity" EXACT [EC:2.1.4.1] synonym: "glycine transamidinase activity" EXACT [EC:2.1.4.1] synonym: "L-arginine:glycine amidinotransferase activity" EXACT [EC:2.1.4.1] xref: EC:2.1.4.1 xref: GO:0015068 xref: MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN xref: Reactome:19902 is_a: CCO:F0002554 ! amidinotransferase activity [Term] id: CCO:F0002556 name: scyllo-inosamine-4-phosphate amidinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate = L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate." [EC:2.1.4.2] subset: gosubset_prok synonym: "inosamine-P amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "inosamine-phosphate amidinotransferase activity" EXACT [] synonym: "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "L-arginine:inosamine phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "L-arginine:inosamine-P-amidinotransferase activity" EXACT [EC:2.1.4.2] xref: EC:2.1.4.2 xref: GO:0015069 xref: MetaCyc:2.1.4.2-RXN is_a: CCO:F0002554 ! amidinotransferase activity [Term] id: CCO:F0002557 name: ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an ion from one side of a membrane to the other." [GOC:def, GOC:df, GOC:mtg_transport, ISBN:0815340729] subset: goslim_goa subset: gosubset_prok synonym: "ion transporter activity" EXACT [] xref: GO:0015075 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0002558 name: monovalent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "univalent inorganic cation transporter" EXACT [] xref: GO:0015077 is_a: CCO:F0004309 ! inorganic cation transmembrane transporter activity [Term] id: CCO:F0002559 name: hydrogen ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "proton transporter" EXACT [] xref: GO:0015078 xref: Reactome:1383 is_a: CCO:F0002558 ! monovalent inorganic cation transmembrane transporter activity [Term] id: CCO:F0002560 name: potassium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "potassium transporter" EXACT [] xref: GO:0015079 xref: GO:0022817 is_a: CCO:F0002558 ! monovalent inorganic cation transmembrane transporter activity is_a: CCO:F0006258 ! metal ion transmembrane transporter activity [Term] id: CCO:F0002561 name: silver ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of silver (Ag) ions from one side of a membrane to the other." [GOC:ai] synonym: "silver transporter" EXACT [] xref: GO:0015080 is_a: CCO:F0002558 ! monovalent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0002562 name: sodium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "sodium transporter" EXACT [] xref: GO:0015081 xref: GO:0022816 is_a: CCO:F0002558 ! monovalent inorganic cation transmembrane transporter activity is_a: CCO:F0006258 ! metal ion transmembrane transporter activity [Term] id: CCO:F0002563 name: di-, tri-valent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of inorganic cations with a valency of two or three from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015082 is_a: CCO:F0004309 ! inorganic cation transmembrane transporter activity [Term] id: CCO:F0002564 name: aluminum ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of aluminum (Al) ions from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "aluminium ion transporter activity" EXACT [] synonym: "aluminium resistance permease activity" EXACT [] synonym: "aluminum resistance permease activity" EXACT [] xref: GO:0015083 xref: GO:0015084 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006258 ! metal ion transmembrane transporter activity [Term] id: CCO:F0002565 name: calcium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:df] subset: gosubset_prok xref: GO:0015085 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006258 ! metal ion transmembrane transporter activity [Term] id: CCO:F0002566 name: cadmium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cadmium (Cd) ions from one side of a membrane to the other." [GOC:df] subset: gosubset_prok synonym: "zinc, cadmium uptake permease activity" NARROW [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] xref: GO:0015086 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0002567 name: cobalt ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other." [GOC:df] subset: gosubset_prok synonym: "cobalt, zinc uptake permease activity" NARROW [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] xref: GO:0015087 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0002568 name: copper uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in)." [TC:9.A.12.-.-] xref: GO:0015088 is_a: CCO:F0001598 ! copper ion transmembrane transporter activity [Term] id: CCO:F0002569 name: high affinity copper ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu2+(out) = Cu2+(in)." [TC:9.A.11.1.1] synonym: "high affinity copper transporter" EXACT [] xref: GO:0015089 is_a: CCO:F0001598 ! copper ion transmembrane transporter activity [Term] id: CCO:F0002570 name: low affinity iron ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in)." [TC:9.A.9.1.1] synonym: "low affinity iron transporter" EXACT [] xref: GO:0015090 is_a: CCO:F0001599 ! iron ion transmembrane transporter activity [Term] id: CCO:F0002571 name: ferric iron transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015091 is_a: CCO:F0001599 ! iron ion transmembrane transporter activity [Term] id: CCO:F0002572 name: high affinity ferric uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of Fe(III) from the outside of a cell to the inside of a cell across a membrane." [GOC:ai, TC:9.A.10.1.1] xref: GO:0015092 is_a: CCO:F0002571 ! ferric iron transmembrane transporter activity [Term] id: CCO:F0002573 name: ferrous iron transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015093 is_a: CCO:F0001599 ! iron ion transmembrane transporter activity [Term] id: CCO:F0002574 name: lead ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lead (Pb) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] xref: GO:0015094 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006258 ! metal ion transmembrane transporter activity [Term] id: CCO:F0002575 name: magnesium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:df] subset: gosubset_prok xref: GO:0015095 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006258 ! metal ion transmembrane transporter activity [Term] id: CCO:F0002576 name: mercury ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015097 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0002577 name: molybdate ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "molybdate transporter activity" EXACT [] xref: GO:0015098 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002578 name: nickel ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nickel (Ni) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] xref: GO:0015099 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0002579 name: vanadium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of vanadium (V) ions from one side of a membrane to the other." [GOC:ai] xref: GO:0015100 is_a: CCO:F0002563 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: CCO:F0006269 ! transition metal ion transmembrane transporter activity [Term] id: CCO:F0002580 name: organic cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015101 is_a: CCO:F0001835 ! cation transmembrane transporter activity [Term] id: CCO:F0002581 name: inorganic anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai] subset: gosubset_prok xref: GO:0015103 is_a: CCO:F0001962 ! anion transmembrane transporter activity [Term] id: CCO:F0002582 name: antimonite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of antimonite from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015104 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002583 name: arsenite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arsenite from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015105 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002584 name: bicarbonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] xref: GO:0015106 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002585 name: chlorate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of chlorate from one side of a membrane to the other. Chlorates are inorganic salts of chloric acid that contain the ClO3- ion." [http://cancerweb.ncl.ac.uk/] xref: GO:0015107 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002586 name: chloride transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of chloride ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015108 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002587 name: chromate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3." [GOC:ai] subset: gosubset_prok xref: GO:0015109 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002588 name: cyanate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015110 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002589 name: iodide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of iodide ions from one side of a membrane to the other." [GOC:ai] xref: GO:0015111 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002590 name: nitrate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrate ions (NO3-) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "nitrite/nitrate porter activity" NARROW [] xref: GO:0015112 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002591 name: nitrite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrite (NO2(-)) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "nitrite/nitrate porter activity" NARROW [] xref: GO:0015113 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002592 name: phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015114 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002593 name: silicate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai, http://cancerweb.ncl.ac.uk/] xref: GO:0015115 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002594 name: sulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfate ions (SO4 2-) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "sulfate permease activity" RELATED [] synonym: "sulphate transporter activity" EXACT [] xref: GO:0015116 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002595 name: thiosulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of thiosulfate ions (S2O3 2-) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "thiosulfate permease activity" RELATED [] synonym: "thiosulphate transporter activity" EXACT [] xref: GO:0015117 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002596 name: tellurite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals." [GOC:ai, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok xref: GO:0015118 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0002597 name: hexose phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of hexose phosphate from one side of the membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015119 is_a: CCO:F0002622 ! monosaccharide transmembrane transporter activity [Term] id: CCO:F0002598 name: phosphoglycerate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphoglycerates from one side of the membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis." [GOC:ai] subset: gosubset_prok xref: GO:0015120 is_a: CCO:F0001570 ! organic acid transmembrane transporter activity is_a: CCO:F0001967 ! organic anion transmembrane transporter activity [Term] id: CCO:F0002599 name: phosphoenolpyruvate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphoenolpyruvate from one side of a membrane to the other. Phosphoenolpyruvate is the phosphate ester formed from the hydroxy group of the enol tautomer of pyruvate. It is a key intermediate in glycolysis and gluconeogenesis, and in the biosynthesis of aromatic amino acids." [GOC:ai] xref: GO:0015121 is_a: CCO:F0001967 ! organic anion transmembrane transporter activity [Term] id: CCO:F0002600 name: acetate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of acetate from one side of the membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai] xref: GO:0015123 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002601 name: allantoate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of allantoate from one side of the membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [GOC:ai, ISBN:0198547684] xref: GO:0015124 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002602 name: bile acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai] xref: GO:0015125 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002603 name: canalicular bile acid transmembrane transporter activity namespace: molecular_function xref: GO:0015126 is_a: CCO:F0002602 ! bile acid transmembrane transporter activity [Term] id: CCO:F0002604 name: bilirubin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of bilirubin from one side of the membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684] xref: GO:0015127 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002605 name: gluconate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of gluconate from one side of the membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] xref: GO:0015128 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002606 name: lactate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] xref: GO:0015129 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002607 name: mevalonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of mevalonate from one side of the membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] xref: GO:0015130 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002608 name: oxaloacetate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of the membrane to the other." [GOC:ai] xref: GO:0015131 is_a: CCO:F0001551 ! dicarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002609 name: prostaglandin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [GOC:ai] synonym: "prostaglandin/thromboxane transporter activity" BROAD [] xref: GO:0015132 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002610 name: uronic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of uronic acid from one side of the membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [GOC:ai] subset: gosubset_prok xref: GO:0015133 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002611 name: hexuronate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of hexuronates from one side of the membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015134 is_a: CCO:F0002610 ! uronic acid transmembrane transporter activity [Term] id: CCO:F0002612 name: glucuronate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glucuronate from one side of the membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] xref: GO:0015135 is_a: CCO:F0002611 ! hexuronate transmembrane transporter activity [Term] id: CCO:F0002613 name: sialic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sialic acid from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015136 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity [Term] id: CCO:F0002614 name: citrate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015137 is_a: CCO:F0002619 ! tricarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002615 name: fumarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of fumarate from one side of the membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] xref: GO:0015138 is_a: CCO:F0001551 ! dicarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002616 name: alpha-ketoglutarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of alpha-ketoglutarate from one side of the membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle." [GOC:ai, ISBN:0198547684] subset: gosubset_prok synonym: "2-oxoglutarate transporter" EXACT [] xref: GO:0015139 is_a: CCO:F0001551 ! dicarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002617 name: malate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of malate from one side of the membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] xref: GO:0015140 is_a: CCO:F0001551 ! dicarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002618 name: succinate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] xref: GO:0015141 is_a: CCO:F0001551 ! dicarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002619 name: tricarboxylic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [GOC:ai] subset: gosubset_prok synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: GO:0015142 is_a: CCO:F0006282 ! carboxylic acid transmembrane transporter activity [Term] id: CCO:F0002620 name: urate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of urate from one side of the membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [GOC:ai] synonym: "uric acid transmembrane transporter activity" EXACT [] xref: GO:0015143 is_a: CCO:F0001570 ! organic acid transmembrane transporter activity [Term] id: CCO:F0002621 name: carbohydrate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of carbohydrate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sugar transporter" NARROW [] xref: GO:0015144 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0002622 name: monosaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of monosaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015145 is_a: CCO:F0008062 ! sugar transmembrane transporter activity [Term] id: CCO:F0002623 name: pentose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a pentose sugar, a monosaccharide with 5 carbon atoms, from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015146 is_a: CCO:F0002622 ! monosaccharide transmembrane transporter activity [Term] id: CCO:F0002624 name: L-arabinose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-arabinose from one side of the membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] xref: GO:0015147 is_a: CCO:F0005736 ! arabinose transmembrane transporter activity [Term] id: CCO:F0002625 name: D-xylose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-xylose from one side of the membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok xref: GO:0015148 is_a: CCO:F0002623 ! pentose transmembrane transporter activity [Term] id: CCO:F0002626 name: hexose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015149 is_a: CCO:F0002622 ! monosaccharide transmembrane transporter activity [Term] id: CCO:F0002627 name: fucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of fucose from one side of the membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015150 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0002628 name: alpha-glucoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of alpha-glucosides from one side of the membrane to the other. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] xref: GO:0015151 is_a: CCO:F0005760 ! glucoside transmembrane transporter activity [Term] id: CCO:F0002629 name: glucose-6-phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0015152 is_a: CCO:F0002597 ! hexose phosphate transmembrane transporter activity [Term] id: CCO:F0002630 name: rhamnose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of rhamnose from one side of the membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015153 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0002631 name: disaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of disaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015154 is_a: CCO:F0008062 ! sugar transmembrane transporter activity [Term] id: CCO:F0002632 name: lactose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lactose from one side of the membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "lactose permease activity" EXACT [] synonym: "lactose/glucose efflux transporter activity" NARROW [] xref: GO:0015155 xref: GO:0019189 is_a: CCO:F0002631 ! disaccharide transmembrane transporter activity [Term] id: CCO:F0002633 name: melibiose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of melibiose from one side of the membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok xref: GO:0015156 is_a: CCO:F0002631 ! disaccharide transmembrane transporter activity [Term] id: CCO:F0002634 name: oligosaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oligosaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "endosomal oligosaccharide transporter" NARROW [] xref: GO:0015157 is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity [Term] id: CCO:F0002635 name: raffinose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of raffinose from one side of the membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "raffinose permease" RELATED [] xref: GO:0015158 is_a: CCO:F0002634 ! oligosaccharide transmembrane transporter activity [Term] id: CCO:F0002636 name: polysaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of polysaccharides from one side of the membrane to the other. A polysaccharide is a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015159 is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity [Term] id: CCO:F0002637 name: beta-glucan transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of beta-glucans from one side of the membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0015160 is_a: CCO:F0002636 ! polysaccharide transmembrane transporter activity [Term] id: CCO:F0002638 name: capsular-polysaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of capsular-polysaccharides from one side of the membrane to the other. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "capsule polysaccharide transporter activity" EXACT [] xref: GO:0015161 is_a: CCO:F0002636 ! polysaccharide transmembrane transporter activity [Term] id: CCO:F0002639 name: teichoic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of teichoic acid from one side of the membrane to the other. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015162 is_a: CCO:F0002636 ! polysaccharide transmembrane transporter activity [Term] id: CCO:F0002640 name: hexuronide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a hexuronide from one side of the membrane to the other. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015163 is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity [Term] id: CCO:F0002641 name: glucuronoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a glucuronosides from one side of the membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "glucuronide transporter activity" EXACT [] xref: GO:0015164 is_a: CCO:F0002640 ! hexuronide transmembrane transporter activity [Term] id: CCO:F0002642 name: pyrimidine nucleotide sugar transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0015165 is_a: CCO:F0001568 ! nucleotide-sugar transmembrane transporter activity [Term] id: CCO:F0002643 name: polyol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sugar/polyol channel activity" NARROW [] xref: GO:0015166 is_a: CCO:F0003013 ! alcohol transmembrane transporter activity [Term] id: CCO:F0002644 name: arabitol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an arabitol from one side of the membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "arabinitol transporter activity" EXACT [] xref: GO:0015167 is_a: CCO:F0002643 ! polyol transmembrane transporter activity [Term] id: CCO:F0002645 name: glycerol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] subset: gosubset_prok xref: GO:0015168 is_a: CCO:F0002643 ! polyol transmembrane transporter activity [Term] id: CCO:F0002646 name: glycerol-3-phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycerol-3-phosphate from one side of the membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] subset: gosubset_prok xref: GO:0015169 is_a: CCO:F0002645 ! glycerol transmembrane transporter activity [Term] id: CCO:F0002647 name: propanediol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of propanediol from one side of the membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [GOC:ai] xref: GO:0015170 is_a: CCO:F0002643 ! polyol transmembrane transporter activity [Term] id: CCO:F0002648 name: amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and can combine in linear arrays to form proteins in living organisms." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "amino acid permease activity" EXACT [] synonym: "amino acid transporter activity" BROAD [] synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "general amino acid permease activity" RELATED [] synonym: "hydroxy/aromatic amino acid permease activity" NARROW [] xref: GO:0015171 xref: GO:0015359 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0006282 ! carboxylic acid transmembrane transporter activity [Term] id: CCO:F0002649 name: acidic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "acidic amino acid transporter activity" BROAD [] xref: GO:0015172 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0002650 name: aromatic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "aromatic amino acid transporter activity" BROAD [] synonym: "hydroxy/aromatic amino acid permease activity" NARROW [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] xref: GO:0015173 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0002651 name: basic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "basic amino acid permease activity" EXACT [] synonym: "basic amino acid transporter activity" BROAD [] xref: GO:0005286 xref: GO:0015174 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0002652 name: neutral amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "neutral amino acid transporter activity" BROAD [] xref: GO:0015175 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0002653 name: L-amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the levorotatory isomer of amino acids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-amino acid transporter activity" BROAD [] xref: GO:0015179 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0002654 name: L-alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-alanine from one side of a membrane to the other. L-alanine, the levorotatory isomer of 2-aminopropanoic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "L-alanine transporter activity" BROAD [] xref: GO:0015180 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity is_a: CCO:F0004285 ! alanine transmembrane transporter activity [Term] id: CCO:F0002655 name: arginine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "arginine permease activity" EXACT [] synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-arginine transporter activity" NARROW [] xref: GO:0005288 xref: GO:0015181 is_a: CCO:F0002651 ! basic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002656 name: L-asparagine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the levorotatory isomer of alpha-aminosuccinamic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "asparagine/glutamine permease activity" NARROW [] synonym: "L-asparagine transporter activity" BROAD [] xref: GO:0015182 is_a: CCO:F0002651 ! basic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002657 name: L-aspartate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-aspartate transporter activity" BROAD [] xref: GO:0015183 is_a: CCO:F0002649 ! acidic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002658 name: L-cystine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-cystine from one side of a membrane to the other." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] synonym: "cystine/diaminopimelate porter activity" NARROW [] synonym: "L-cystine transporter activity" BROAD [] xref: GO:0015184 is_a: CCO:F0000019 ! sulfur amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002659 name: L-gamma-aminobutyric acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-gamma-aminobutyric acid from one side of a membrane to the other. L-gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "4-aminobutanoate transporter activity" EXACT [] synonym: "4-aminobutyrate transporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "GABA transporter activity" EXACT [] synonym: "L-gamma-aminobutyrate transporter activity" EXACT [] synonym: "L-gamma-aminobutyric acid transporter activity" BROAD [] xref: GO:0015185 is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002660 name: L-glutamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "asparagine/glutamine permease activity" NARROW [] xref: GO:0015186 is_a: CCO:F0002651 ! basic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002661 name: glycine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai] subset: gosubset_prok synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "glycine transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] xref: GO:0015187 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity [Term] id: CCO:F0002662 name: L-isoleucine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "L-isoleucine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] xref: GO:0015188 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002663 name: L-lysine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-lysine permease" RELATED [] synonym: "lysine permease activity" RELATED [] xref: GO:0005293 xref: GO:0015189 is_a: CCO:F0002651 ! basic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002664 name: L-leucine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-leucine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] xref: GO:0015190 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002665 name: L-methionine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-methionine transporter activity" BROAD [] xref: GO:0015191 is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity is_a: CCO:F0006027 ! methionine transmembrane transporter activity [Term] id: CCO:F0002666 name: L-phenylalanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-phenylalanine permease activity" EXACT [] synonym: "L-phenylalanine transporter activity" BROAD [] xref: GO:0015192 is_a: CCO:F0002650 ! aromatic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002667 name: L-proline transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "L-proline permease activity" RELATED [] synonym: "L-proline transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] xref: GO:0005296 xref: GO:0015193 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002668 name: L-serine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-serine from one side of a membrane to the other. L-serine is the levorotatory isomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-serine permease activity" RELATED [] synonym: "L-serine transporter activity" BROAD [] synonym: "serine transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" NARROW [] xref: GO:0015194 xref: GO:0015511 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity is_a: CCO:F0004308 ! serine transmembrane transporter activity [Term] id: CCO:F0002669 name: L-threonine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-threonine permease activity" RELATED [] synonym: "L-threonine transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" NARROW [] xref: GO:0015195 xref: GO:0015512 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002670 name: L-tryptophan transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-tryptophan permease activity" EXACT [] synonym: "L-tryptophan transporter activity" BROAD [] synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] xref: GO:0005299 xref: GO:0015196 is_a: CCO:F0002650 ! aromatic amino acid transmembrane transporter activity is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002671 name: peptide transporter activity namespace: molecular_function def: "Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells." [GOC:ai] subset: gosubset_prok synonym: "peptide uptake permease activity" RELATED [] xref: GO:0015197 xref: GO:0015637 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0002672 name: oligopeptide transporter activity namespace: molecular_function def: "Enables the directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015198 is_a: CCO:F0002671 ! peptide transporter activity [Term] id: CCO:F0002673 name: betaine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of betaine, the N-trimethyl derivative of an amino acid, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] xref: GO:0015199 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0002674 name: methylammonium transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of methylammonium, CH3NH2, into, out of, within or between cells." [GOC:ai] xref: GO:0015200 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0002675 name: polyamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of polyamines, organic compounds containing two or more amino groups, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "amine/amide/polyamine channel activity" NARROW [] xref: GO:0015203 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0002676 name: urea transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of urea cross a membrane into, out of, within or between cells. Urea is the water soluble compound H2N-CO-NH2, produced in the liver via the ornithine-urea cycle. It is the main nitrogen-containing (urinary) excretion product in ureotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "urea transporter activity" BROAD [] xref: GO:0015204 xref: GO:0015287 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity is_a: CCO:F0005729 ! amide transporter activity [Term] id: CCO:F0002677 name: nucleobase transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015205 xref: GO:0015392 is_a: CCO:F0003026 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: CCO:F0002678 name: adenine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators] xref: GO:0015207 xref: Reactome:21842 is_a: CCO:F0001573 ! purine transmembrane transporter activity [Term] id: CCO:F0002679 name: guanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other." [GOC:go_curators] xref: GO:0015208 is_a: CCO:F0001573 ! purine transmembrane transporter activity [Term] id: CCO:F0002680 name: cytosine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other." [GOC:go_curators] subset: gosubset_prok xref: GO:0015209 is_a: CCO:F0001576 ! pyrimidine transmembrane transporter activity [Term] id: CCO:F0002681 name: uracil transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other." [GOC:go_curators] subset: gosubset_prok synonym: "uracil/uridine permease activity" RELATED [] xref: GO:0015210 is_a: CCO:F0001576 ! pyrimidine transmembrane transporter activity [Term] id: CCO:F0002682 name: purine nucleoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015211 is_a: CCO:F0001567 ! nucleoside transmembrane transporter activity [Term] id: CCO:F0002683 name: cytidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [GOC:go_curators] xref: GO:0015212 is_a: CCO:F0002685 ! pyrimidine nucleoside transmembrane transporter activity [Term] id: CCO:F0002684 name: uridine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of uridine, uracil riboside, from one side of a membrane to the other." [GOC:go_curators] synonym: "uracil/uridine permease activity" NARROW [] xref: GO:0015213 is_a: CCO:F0002685 ! pyrimidine nucleoside transmembrane transporter activity [Term] id: CCO:F0002685 name: pyrimidine nucleoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other." [GOC:ai] xref: GO:0015214 is_a: CCO:F0001567 ! nucleoside transmembrane transporter activity [Term] id: CCO:F0002686 name: nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015215 is_a: CCO:F0003026 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: CCO:F0002687 name: purine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] xref: GO:0015216 is_a: CCO:F0002686 ! nucleotide transmembrane transporter activity [Term] id: CCO:F0002688 name: ADP transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai] xref: GO:0015217 is_a: CCO:F0000061 ! adenine nucleotide transmembrane transporter activity [Term] id: CCO:F0002689 name: pyrimidine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] xref: GO:0015218 is_a: CCO:F0002686 ! nucleotide transmembrane transporter activity [Term] id: CCO:F0002690 name: DNA-protein complex transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of DNA-protein complexes from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015219 is_a: CCO:F0003026 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: CCO:F0002691 name: choline transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] subset: gosubset_prok synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "choline permease activity" EXACT [] xref: GO:0005306 xref: GO:0015220 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0002692 name: lipopolysaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lipopolysaccharides from one side of the membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "LPS transmembrane transporter activity" EXACT [] xref: GO:0015221 is_a: CCO:F0002636 ! polysaccharide transmembrane transporter activity [Term] id: CCO:F0002693 name: serotonin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] xref: GO:0015222 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0001559 ! neurotransmitter transporter activity [Term] id: CCO:F0002694 name: biopterin transporter activity namespace: molecular_function def: "Enables the directed movement of biopterin into, out of, within or between cells. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0015224 is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0002695 name: biotin transporter activity namespace: molecular_function def: "Enables the directed movement of biotin into, out of, within or between cells. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] synonym: "vitamin B7 transporter activity" EXACT [] synonym: "vitamin H transporter activity" EXACT [] xref: GO:0015225 is_a: CCO:F0008065 ! vitamin transporter activity is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0002696 name: carnitine transporter activity namespace: molecular_function def: "Enables the directed movement of carnitine into, out of, within or between cells. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] subset: gosubset_prok synonym: "vitamin Bt transporter activity" EXACT [] xref: GO:0015226 is_a: CCO:F0008065 ! vitamin transporter activity is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0002697 name: acyl carnitine transporter activity namespace: molecular_function def: "Enables the directed movement of acyl carnitine into, out of, within or between cells. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai, http://cancerweb.ncl.ac.uk/] synonym: "acylcarnitine transporter activity" EXACT [] xref: GO:0015227 is_a: CCO:F0002696 ! carnitine transporter activity [Term] id: CCO:F0002698 name: coenzyme A transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of coenzyme A across a membrane into, out of, within or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] synonym: "coenzyme A transporter activity" BROAD [] xref: GO:0015228 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity is_a: CCO:F0008067 ! coenzyme transporter activity [Term] id: CCO:F0002699 name: L-ascorbic acid transporter activity namespace: molecular_function def: "Enables the directed movement of L-ascorbate into, out of, within or between cells. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "L-ascorbate transporter activity" EXACT [] synonym: "vitamin C transporter activity" EXACT [] xref: GO:0015229 is_a: CCO:F0008065 ! vitamin transporter activity [Term] id: CCO:F0002700 name: FAD transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of, within or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "FAD transporter activity" BROAD [] synonym: "flavin adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT [] xref: GO:0015230 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0002701 name: 5-formyltetrahydrofolate transporter activity namespace: molecular_function def: "Enables the directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells." [GOC:ai] xref: GO:0015231 is_a: CCO:F0001970 ! folic acid transporter activity [Term] id: CCO:F0002702 name: heme transporter activity namespace: molecular_function def: "Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells." [GOC:ai] subset: gosubset_prok synonym: "haem transporter activity" EXACT [] xref: GO:0015232 is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0002703 name: pantothenate transporter activity namespace: molecular_function def: "Enables the directed movement of pantothenate into, out of, within or between cells. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "vitamin B5 transporter activity" EXACT [] xref: GO:0015233 is_a: CCO:F0008065 ! vitamin transporter activity is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0002704 name: thiamin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of thiamin from one side of the membrane to the other. Thiamin is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "thiamin permease activity" EXACT [] synonym: "thiamine permease activity" EXACT [] synonym: "thiamine transmembrane transporter activity" EXACT [] synonym: "vitamin B1 transporter activity" EXACT [] xref: GO:0015234 xref: GO:0015402 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity is_a: CCO:F0008065 ! vitamin transporter activity [Term] id: CCO:F0002705 name: cobalamin transporter activity namespace: molecular_function def: "Enables the directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell." [GOC:ai] subset: gosubset_prok synonym: "vitamin B12 transporter activity" EXACT [] xref: GO:0015235 is_a: CCO:F0008065 ! vitamin transporter activity [Term] id: CCO:F0002706 name: drug transporter activity namespace: molecular_function def: "Enables the directed movement of a drug into, out of, within or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015238 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0002707 name: multidrug transporter activity namespace: molecular_function def: "Enables the directed movement of drugs into, out of, within or between cells." [GOC:ai] subset: gosubset_prok xref: GO:0015239 is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0002708 name: amiloride transporter activity namespace: molecular_function def: "Enables the directed movement of amiloride of amiloride into, out of, within or between cells. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0015240 is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0002709 name: aminotriazole transporter activity namespace: molecular_function def: "Enables the directed movement of aminotriazole into, out of, within or between cells. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [http://cancerweb.ncl.ac.uk/] xref: GO:0015241 is_a: CCO:F0006070 ! azole transporter activity [Term] id: CCO:F0002710 name: benomyl transporter activity namespace: molecular_function def: "Enables the directed movement of benomyl into, out of, within or between cells. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [http://cancerweb.ncl.ac.uk/] xref: GO:0015242 is_a: CCO:F0002706 ! drug transporter activity is_a: CCO:F0005740 ! xenobiotic transporter activity [Term] id: CCO:F0002711 name: cycloheximide transporter activity namespace: molecular_function def: "Enables the directed movement of cycloheximide into, out of, within or between cells. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0015243 is_a: CCO:F0005732 ! antibiotic transporter activity [Term] id: CCO:F0002712 name: fluconazole transporter activity namespace: molecular_function def: "Enables the directed movement of fluconazole into, out of, within or between cells. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [http://cancerweb.ncl.ac.uk/] xref: GO:0015244 is_a: CCO:F0006070 ! azole transporter activity [Term] id: CCO:F0002713 name: fatty acid transporter activity namespace: molecular_function def: "Enables the directed movement of fatty acids into, out of, within or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015245 is_a: CCO:F0001556 ! lipid transporter activity [Term] id: CCO:F0002714 name: fatty acyl transporter activity namespace: molecular_function def: "Enables the directed movement of a fatty acyl group into, out of, within or between cells. A fatty acyl group is any acyl group derived from a fatty acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "peroxisomal fatty acyl transporter" NARROW [] xref: GO:0015246 is_a: CCO:F0001556 ! lipid transporter activity [Term] id: CCO:F0002715 name: aminophospholipid transporter activity namespace: molecular_function def: "Enables the directed movement of aminophospholipids into, out of, within or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai] subset: gosubset_prok xref: GO:0015247 is_a: CCO:F0001671 ! phospholipid transporter activity [Term] id: CCO:F0002716 name: sterol transporter activity namespace: molecular_function def: "Enables the directed movement of sterols into, out of, within or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] xref: GO:0015248 is_a: CCO:F0001556 ! lipid transporter activity [Term] id: CCO:F0002717 name: water channel activity namespace: molecular_function def: "Transport systems of this type catalyze facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "aquaporin" NARROW [] xref: GO:0015250 is_a: CCO:F0001597 ! water transporter activity is_a: CCO:F0004269 ! substrate specific channel activity [Term] id: CCO:F0002718 name: ammonium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of ammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0015251 is_a: CCO:F0001524 ! cation channel activity is_a: CCO:F0001972 ! ammonium transmembrane transporter activity [Term] id: CCO:F0002719 name: hydrogen ion channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0015252 is_a: CCO:F0001524 ! cation channel activity [Term] id: CCO:F0002720 name: glycerol channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of an glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0015254 is_a: CCO:F0002645 ! glycerol transmembrane transporter activity [Term] id: CCO:F0002721 name: propanediol channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] xref: GO:0015255 is_a: CCO:F0002647 ! propanediol transmembrane transporter activity [Term] id: CCO:F0002722 name: methylammonium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of an methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2." [GOC:mtg_transport] xref: GO:0015264 is_a: CCO:F0002674 ! methylammonium transmembrane transporter activity [Term] id: CCO:F0002723 name: urea channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] xref: GO:0015265 is_a: CCO:F0002676 ! urea transmembrane transporter activity is_a: CCO:F0004269 ! substrate specific channel activity [Term] id: CCO:F0002724 name: protein channel activity namespace: molecular_function xref: GO:0015266 is_a: CCO:F0001832 ! protein transmembrane transporter activity is_a: CCO:F0002725 ! channel activity [Term] id: CCO:F0002725 name: channel activity namespace: molecular_function def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-] subset: goslim_goa subset: gosubset_prok synonym: "alpha-type channel activity" RELATED [] synonym: "channel-forming toxin activity" RELATED [] synonym: "channel/pore class transporter activity" EXACT [] synonym: "nonselective channel activity" EXACT [] synonym: "pore activity" BROAD [] synonym: "pore class transporter activity" RELATED [] xref: GO:0015249 xref: GO:0015267 xref: GO:0015268 xref: TC:1 is_a: CCO:F0004250 ! passive transmembrane transporter activity [Term] id: CCO:F0002726 name: calcium-activated potassium channel activity namespace: molecular_function def: "Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] subset: gosubset_prok xref: GO:0015269 is_a: CCO:F0001502 ! calcium activated cation channel activity is_a: CCO:F0001526 ! potassium channel activity is_a: CCO:F0004270 ! ion gated channel activity [Term] id: CCO:F0002727 name: dihydropyridine-sensitive calcium channel activity namespace: molecular_function xref: GO:0015270 is_a: CCO:F0001513 ! voltage-gated calcium channel activity [Term] id: CCO:F0002728 name: outward rectifier potassium channel activity namespace: molecular_function xref: GO:0015271 is_a: CCO:F0001517 ! voltage-gated potassium channel activity [Term] id: CCO:F0002729 name: ATP-activated inward rectifier potassium channel activity namespace: molecular_function xref: GO:0015272 is_a: CCO:F0001510 ! inward rectifier potassium channel activity [Term] id: CCO:F0002730 name: G-protein enhanced inward rectifier potassium channel activity namespace: molecular_function synonym: "G protein enhanced inward rectifier potassium channel activity" EXACT [] synonym: "G-protein-enhanced inward rectifier potassium channel activity" EXACT [] xref: GO:0015273 is_a: CCO:F0001510 ! inward rectifier potassium channel activity [Term] id: CCO:F0002731 name: organellar voltage-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "organellar voltage gated chloride channel activity" EXACT [] synonym: "organellar voltage-dependent chloride channel activity" EXACT [] xref: GO:0015274 is_a: CCO:F0001515 ! voltage-gated chloride channel activity [Term] id: CCO:F0002732 name: stretch-activated, cation-selective, calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [GOC:mtg_transport] xref: GO:0015275 is_a: CCO:F0001525 ! calcium channel activity is_a: CCO:F0001855 ! mechanically-gated ion channel activity [Term] id: CCO:F0002733 name: ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "ionotropic neurotransmitter receptor" NARROW [] xref: GO:0015276 is_a: CCO:F0001492 ! ion channel activity is_a: CCO:F0004266 ! ligand-gated channel activity [Term] id: CCO:F0002734 name: kainate selective glutamate receptor activity namespace: molecular_function comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'inotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. xref: GO:0015277 is_a: CCO:F0001311 ! ionotropic glutamate receptor activity [Term] id: CCO:F0002735 name: calcium-release channel activity namespace: molecular_function xref: GO:0015278 is_a: CCO:F0001525 ! calcium channel activity is_a: CCO:F0002733 ! ligand-gated ion channel activity [Term] id: CCO:F0002736 name: store-operated calcium channel activity namespace: molecular_function xref: GO:0015279 is_a: CCO:F0001525 ! calcium channel activity is_a: CCO:F0002733 ! ligand-gated ion channel activity [Term] id: CCO:F0002737 name: amiloride-sensitive sodium channel activity namespace: molecular_function synonym: "epithelial sodium channel" EXACT [] xref: GO:0015280 is_a: CCO:F0001527 ! sodium channel activity is_a: CCO:F0002733 ! ligand-gated ion channel activity [Term] id: CCO:F0002738 name: fructose uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13] xref: GO:0015284 is_a: CCO:F0001579 ! fructose transmembrane transporter activity is_a: CCO:F0001969 ! hexose uniporter activity [Term] id: CCO:F0002739 name: porin activity namespace: molecular_function def: "Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] subset: gosubset_prok synonym: "outer membrane exporter porin" NARROW [] synonym: "porin" EXACT [] xref: GO:0015288 is_a: CCO:F0004262 ! wide pore channel activity [Term] id: CCO:F0002740 name: secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "active transporter" BROAD [] synonym: "coupled carrier" EXACT [] synonym: "electrochemical potential-driven transporter activity" EXACT [] synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] synonym: "heavy metal ion porter activity" NARROW [] synonym: "nitrite/nitrate porter activity" NARROW [] synonym: "porter activity" EXACT [] synonym: "porters" EXACT [] synonym: "secondary carrier-type facilitators" EXACT [] xref: GO:0015290 xref: GO:0015291 xref: TC:2.A is_a: CCO:F0004251 ! active transmembrane transporter activity [Term] id: CCO:F0002741 name: uniporter activity namespace: molecular_function def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "facilitated diffusion carrier" EXACT [] synonym: "single-species transporter" EXACT [] synonym: "uniport" RELATED [] xref: GO:0015292 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002742 name: symporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "cotransporter" BROAD [] synonym: "porter" BROAD [] synonym: "symport" RELATED [] xref: GO:0015293 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002743 name: solute:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai] subset: gosubset_prok xref: GO:0015294 is_a: CCO:F0001835 ! cation transmembrane transporter activity is_a: CCO:F0002742 ! symporter activity [Term] id: CCO:F0002744 name: solute:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [GOC:ai] subset: gosubset_prok synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] synonym: "solute:proton symporter" EXACT [] xref: GO:0015295 is_a: CCO:F0002743 ! solute:cation symporter activity [Term] id: CCO:F0002745 name: anion:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-] subset: gosubset_prok xref: GO:0015296 is_a: CCO:F0001962 ! anion transmembrane transporter activity is_a: CCO:F0002743 ! solute:cation symporter activity [Term] id: CCO:F0002746 name: antiporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "antiport" RELATED [] synonym: "countertransporter" EXACT [] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] synonym: "exchange transporter" EXACT [] synonym: "exchanger" BROAD [] synonym: "porter" BROAD [] xref: GO:0015297 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002747 name: solute:cation antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai] subset: gosubset_prok xref: GO:0015298 is_a: CCO:F0001835 ! cation transmembrane transporter activity is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0002748 name: solute:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] subset: gosubset_prok synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] synonym: "solute:proton antiporter" EXACT [] xref: GO:0015299 is_a: CCO:F0002747 ! solute:cation antiporter activity [Term] id: CCO:F0002749 name: solute:solute antiporter activity namespace: molecular_function def: "Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:ai] subset: gosubset_prok synonym: "solute:solute exchange" RELATED [] xref: GO:0015300 is_a: CCO:F0002746 ! antiporter activity [Term] id: CCO:F0002750 name: anion:anion antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out)." [GOC:ai, GOC:mtg_transport] subset: gosubset_prok xref: GO:0015301 is_a: CCO:F0001962 ! anion transmembrane transporter activity is_a: CCO:F0002746 ! antiporter activity [Term] id: CCO:F0002751 name: glucose uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)." [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6] synonym: "galactose, glucose uniporter activity" NARROW [] xref: GO:0015304 is_a: CCO:F0001581 ! glucose transmembrane transporter activity is_a: CCO:F0001969 ! hexose uniporter activity [Term] id: CCO:F0002752 name: sialate:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)." [TC:2.A.1.14.10] synonym: "cation/sialate symporter activity" EXACT [] synonym: "cation:sialate symporter activity" EXACT [] synonym: "sialate transporter activity" BROAD [] synonym: "sialate/cation symporter activity" EXACT [] xref: GO:0015306 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0002753 name: drug:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out)." [TC:2.A.1.2.-, TC:2.A.1.3.-] subset: gosubset_prok synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] synonym: "drug:proton antiporter" EXACT [] xref: GO:0015307 is_a: CCO:F0002706 ! drug transporter activity is_a: CCO:F0002748 ! solute:hydrogen antiporter activity [Term] id: CCO:F0002754 name: amiloride:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out)." [TC:2.A.1.2.1] synonym: "amiloride:proton antiporter" EXACT [] xref: GO:0015308 is_a: CCO:F0002753 ! drug:hydrogen antiporter activity [Term] id: CCO:F0002755 name: cycloheximide:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2] synonym: "cycloheximide:proton antiporter" EXACT [] xref: GO:0015309 is_a: CCO:F0002753 ! drug:hydrogen antiporter activity [Term] id: CCO:F0002756 name: benomyl:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6] synonym: "benomyl:proton antiporter" EXACT [] xref: GO:0015310 is_a: CCO:F0002753 ! drug:hydrogen antiporter activity [Term] id: CCO:F0002757 name: monoamine:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12] synonym: "monoamine:proton antiporter" EXACT [] xref: GO:0015311 is_a: CCO:F0001958 ! monoamine transmembrane transporter activity is_a: CCO:F0002748 ! solute:hydrogen antiporter activity [Term] id: CCO:F0002758 name: polyamine:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16] synonym: "polyamine:proton antiporter" EXACT [] xref: GO:0015312 is_a: CCO:F0002675 ! polyamine transmembrane transporter activity is_a: CCO:F0002748 ! solute:hydrogen antiporter activity [Term] id: CCO:F0002759 name: fluconazole:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17] synonym: "fluconazole:proton antiporter" EXACT [] xref: GO:0015313 is_a: CCO:F0006071 ! azole:hydrogen antiporter activity [Term] id: CCO:F0002760 name: aminotriazole:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1] synonym: "aminotriazole:proton antiporter" EXACT [] xref: GO:0015314 is_a: CCO:F0006071 ! azole:hydrogen antiporter activity [Term] id: CCO:F0002761 name: organophosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.-] xref: GO:0015315 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0002762 name: phosphate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] synonym: "phosphate:proton symporter" EXACT [] xref: GO:0015317 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0002763 name: inorganic solute uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an inorganic solute from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "inorganic uptake permease activity" EXACT [] xref: GO:0015318 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity is_a: CCO:F0002943 ! uptake transmembrane transporter activity [Term] id: CCO:F0002764 name: sodium:inorganic phosphate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)." [TC:2.A.1.14.6] xref: GO:0015319 is_a: CCO:F0001613 ! sodium:phosphate symporter activity [Term] id: CCO:F0002765 name: phosphate carrier activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate (cyt) + H+ (cyt) = phosphate (mitochondrion) + H+ (mitochondrion)." [TC:2.A.29.4.1, UniProtKB:P12234] xref: GO:0015320 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity [Term] id: CCO:F0002766 name: sodium-dependent phosphate transmembrane transporter activity namespace: molecular_function subset: gosubset_prok xref: GO:0015321 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity [Term] id: CCO:F0002767 name: secondary active oligopeptide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an oligopeptide or oligopeptides from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] synonym: "oligopeptide porter activity" RELATED [] xref: GO:0015322 is_a: CCO:F0002672 ! oligopeptide transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002768 name: peptide-acetyl-CoA secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "peptide-acetyl-CoA transporter activity" RELATED [] xref: GO:0015324 is_a: CCO:F0002671 ! peptide transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002769 name: acetyl-CoA:CoA antiporter activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1] xref: GO:0015325 is_a: CCO:F0001974 ! acetyl-CoA transporter activity is_a: CCO:F0002749 ! solute:solute antiporter activity is_a: CCO:F0002768 ! peptide-acetyl-CoA secondary active transmembrane transporter activity [Term] id: CCO:F0002770 name: cationic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a positively charged amino acid from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0015326 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0001835 ! cation transmembrane transporter activity [Term] id: CCO:F0002771 name: cystine:glutamate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5] xref: GO:0015327 is_a: CCO:F0001541 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: CCO:F0001552 ! L-glutamate transmembrane transporter activity is_a: CCO:F0002658 ! L-cystine transmembrane transporter activity is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0002772 name: cystine secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "cystine porter activity" RELATED [] synonym: "cystinosin" NARROW [] synonym: "lysosomal cystine transporter" NARROW [] xref: GO:0015328 is_a: CCO:F0001541 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: CCO:F0002658 ! L-cystine transmembrane transporter activity [Term] id: CCO:F0002773 name: high affinity glutamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the high affinity transfer of glutamine from one side of the membrane to the other." [GOC:mtg_transport] synonym: "high affinity glutamine permease activity" RELATED [] xref: GO:0015330 is_a: CCO:F0001536 ! high affinity basic amino acid transmembrane transporter activity is_a: CCO:F0002660 ! L-glutamine transmembrane transporter activity [Term] id: CCO:F0002774 name: peptide:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). Catalysis of the transfer of an peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement." [GOC:mtg_transport, TC:2.A.17.-.-] subset: gosubset_prok synonym: "peptide:proton symporter" EXACT [] xref: GO:0015333 is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0004314 ! proton-dependent peptide secondary active transmembrane transporter activity [Term] id: CCO:F0002775 name: high affinity oligopeptide transporter activity namespace: molecular_function def: "Catalysis of the transfer of oligopeptide from one side of the membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:mtg_transport] xref: GO:0015334 is_a: CCO:F0002672 ! oligopeptide transporter activity [Term] id: CCO:F0002776 name: zinc efflux active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3] synonym: "zinc efflux permease activity" BROAD [] xref: GO:0015341 is_a: CCO:F0001524 ! cation channel activity is_a: CCO:F0001601 ! zinc ion transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity is_a: CCO:F0004304 ! zinc efflux transmembrane transporter activity [Term] id: CCO:F0002777 name: siderophore-iron transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [TC:2.A.1.16.-] subset: gosubset_prok synonym: "iron-siderophore transporter activity" EXACT [] synonym: "siderochrome-iron transporter activity" NARROW [] xref: GO:0015236 xref: GO:0015237 xref: GO:0015343 is_a: CCO:F0001599 ! iron ion transmembrane transporter activity is_a: CCO:F0005750 ! siderophore transporter activity [Term] id: CCO:F0002778 name: siderophore-iron (ferrioxamine) uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [TC:2.A.1.16.1] synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW [] xref: GO:0015344 is_a: CCO:F0002777 ! siderophore-iron transmembrane transporter activity [Term] id: CCO:F0002779 name: ferric enterobactin:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2] synonym: "ferric-enterobactin:proton symporter" EXACT [] xref: GO:0015345 is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0002980 ! ferric-enterobactin transmembrane transporter activity [Term] id: CCO:F0002780 name: ferric triacetylfusarinine C:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3] synonym: "ferric triacetylfusarinine C:proton symporter" EXACT [] xref: GO:0015346 is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0002777 ! siderophore-iron transmembrane transporter activity is_a: CCO:F0002981 ! ferric triacetylfusarinine C transmembrane transporter activity [Term] id: CCO:F0002781 name: sodium-independent organic anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner." [GOC:go_curators] xref: GO:0015347 is_a: CCO:F0001967 ! organic anion transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002782 name: thyroid hormone transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of thyroid hormones from one side of the membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai] xref: GO:0015349 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002783 name: methotrexate transporter activity namespace: molecular_function def: "Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of, within or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] xref: GO:0015350 is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0002784 name: bilirubin secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "bilirubin porter activity" RELATED [] synonym: "bilitranslocase" NARROW [] xref: GO:0015351 is_a: CCO:F0002604 ! bilirubin transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002785 name: secondary active sterol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sterol from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] synonym: "sterol porter activity" RELATED [] xref: GO:0015352 is_a: CCO:F0002716 ! sterol transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002786 name: multidrug endosomal transmembrane transporter activity namespace: molecular_function xref: GO:0015353 is_a: CCO:F0002707 ! multidrug transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002787 name: polyspecific organic cation transmembrane transporter activity namespace: molecular_function xref: GO:0015354 is_a: CCO:F0001966 ! secondary active organic cation transmembrane transporter activity [Term] id: CCO:F0002788 name: secondary active monocarboxylate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl] synonym: "monocarboxylate porter activity" RELATED [] xref: GO:0015355 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002789 name: acetate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1] synonym: "acetate:proton symporter" EXACT [] synonym: "hydrogen:acetate symporter activity" EXACT [] xref: GO:0015357 xref: GO:0015360 is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0006055 ! acetate:cation symporter activity [Term] id: CCO:F0002790 name: low affinity sodium:dicarboxylate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1] synonym: "low affinity sodium:dicarboxylate cotransporter activity" EXACT [] xref: GO:0015361 is_a: CCO:F0003597 ! sodium:dicarboxylate symporter activity [Term] id: CCO:F0002791 name: high affinity sodium:dicarboxylate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4] synonym: "high affinity sodium:dicarboxylate cotransporter activity" EXACT [] xref: GO:0015362 is_a: CCO:F0003597 ! sodium:dicarboxylate symporter activity [Term] id: CCO:F0002792 name: dicarboxylate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)." [TC:2.A.29.2.3] xref: GO:0015364 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity is_a: CCO:F0002746 ! antiporter activity [Term] id: CCO:F0002793 name: malate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)." [TC:2.A.16.2.1] synonym: "malate:proton symporter" EXACT [] xref: GO:0015366 is_a: CCO:F0002617 ! malate transmembrane transporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0002794 name: oxoglutarate:malate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1] xref: GO:0015367 is_a: CCO:F0002749 ! solute:solute antiporter activity is_a: CCO:F0002750 ! anion:anion antiporter activity [Term] id: CCO:F0002795 name: calcium:cation antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-] subset: gosubset_prok xref: GO:0015368 is_a: CCO:F0002886 ! cation:cation antiporter activity [Term] id: CCO:F0002796 name: calcium:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [TC:2.A.19.2.-] subset: gosubset_prok synonym: "calcium:proton antiporter" EXACT [] xref: GO:0015369 is_a: CCO:F0002795 ! calcium:cation antiporter activity is_a: CCO:F0008064 ! metal ion:hydrogen antiporter activity [Term] id: CCO:F0002797 name: solute:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] xref: GO:0015370 is_a: CCO:F0002743 ! solute:cation symporter activity [Term] id: CCO:F0002798 name: galactose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] xref: GO:0015371 is_a: CCO:F0001580 ! galactose transmembrane transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0002799 name: monovalent anion:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in)." [TC:2.A.21.5.-] xref: GO:0015373 is_a: CCO:F0002745 ! anion:cation symporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0002800 name: neutral, cationic amino acid:sodium:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/cationic amino acid(out) + Na+(out) + Cl-(out) = neutral/cationic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3] xref: GO:0015374 is_a: CCO:F0001534 ! sodium:amino acid symporter activity is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity [Term] id: CCO:F0002801 name: glycine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)." [GOC:ai] xref: GO:0015375 xref: GO:0015656 is_a: CCO:F0001534 ! sodium:amino acid symporter activity is_a: CCO:F0001541 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: CCO:F0002661 ! glycine transmembrane transporter activity [Term] id: CCO:F0002802 name: cation:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-] synonym: "cation:chloride cotransporter activity" EXACT [] xref: GO:0015377 is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0002803 name: sodium:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-] xref: GO:0015378 is_a: CCO:F0002802 ! cation:chloride symporter activity [Term] id: CCO:F0002804 name: potassium:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.5.-] xref: GO:0015379 is_a: CCO:F0002802 ! cation:chloride symporter activity [Term] id: CCO:F0002805 name: anion exchanger activity namespace: molecular_function synonym: "bicarbonate:chloride antiporter" NARROW [] xref: GO:0015380 xref: GO:0015384 is_a: CCO:F0002584 ! bicarbonate transmembrane transporter activity is_a: CCO:F0002586 ! chloride transmembrane transporter activity is_a: CCO:F0002750 ! anion:anion antiporter activity [Term] id: CCO:F0002806 name: high affinity sulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the secondary active high affinity transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity sulfate permease activity" RELATED [] synonym: "high affinity sulphate permease activity" EXACT [] xref: GO:0015381 is_a: CCO:F0001811 ! secondary active sulfate transmembrane transporter activity [Term] id: CCO:F0002807 name: sodium:sulfate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2] synonym: "sodium:sulfate cotransporter activity" EXACT [] synonym: "sodium:sulphate symporter activity" EXACT [] xref: GO:0015382 is_a: CCO:F0001811 ! secondary active sulfate transmembrane transporter activity is_a: CCO:F0002562 ! sodium ion transmembrane transporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0002808 name: sulfate:bicarbonate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2] synonym: "sulphate:bicarbonate antiporter activity" EXACT [] xref: GO:0015383 is_a: CCO:F0001811 ! secondary active sulfate transmembrane transporter activity is_a: CCO:F0002584 ! bicarbonate transmembrane transporter activity is_a: CCO:F0002750 ! anion:anion antiporter activity [Term] id: CCO:F0002809 name: sodium:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] subset: gosubset_prok synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW [] synonym: "pH-dependent sodium:proton antiporter" NARROW [] synonym: "sodium/hydrogen antiporter" EXACT [] synonym: "sodium:hydrogen exchange activity" EXACT [] synonym: "sodium:hydrogen exchanger" EXACT [] synonym: "sodium:proton antiporter" EXACT [] xref: GO:0015385 xref: GO:0015502 is_a: CCO:F0001614 ! monovalent cation:proton antiporter activity [Term] id: CCO:F0002810 name: potassium:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-] subset: gosubset_prok synonym: "potassium:proton antiporter" EXACT [] xref: GO:0015386 is_a: CCO:F0001614 ! monovalent cation:proton antiporter activity is_a: CCO:F0004259 ! potassium ion antiporter activity [Term] id: CCO:F0002811 name: potassium:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)." [TC:2.A.38.-.-] synonym: "potassium:proton symporter" EXACT [] xref: GO:0015387 is_a: CCO:F0002559 ! hydrogen ion transmembrane transporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0004258 ! potassium ion symporter activity [Term] id: CCO:F0002812 name: potassium uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of potassium from the outside of a cell to the inside of the cell across a membrane: K+(out) + energy = K+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.72.2.-] synonym: "potassium uptake permease activity" EXACT [] xref: GO:0015388 is_a: CCO:F0002560 ! potassium ion transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity is_a: CCO:F0002943 ! uptake transmembrane transporter activity [Term] id: CCO:F0002813 name: pyrimidine- and adenine-specific:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in)." [TC:2.A.41.2.3] xref: GO:0015389 is_a: CCO:F0001573 ! purine transmembrane transporter activity is_a: CCO:F0001576 ! pyrimidine transmembrane transporter activity is_a: CCO:F0001607 ! nucleoside:sodium symporter activity [Term] id: CCO:F0002814 name: purine-specific nucleoside:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1] xref: GO:0015390 is_a: CCO:F0001607 ! nucleoside:sodium symporter activity [Term] id: CCO:F0002815 name: nucleobase:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [GOC:ai] subset: gosubset_prok xref: GO:0015391 is_a: CCO:F0002677 ! nucleobase transmembrane transporter activity is_a: CCO:F0002743 ! solute:cation symporter activity [Term] id: CCO:F0002816 name: uridine:hydrogen ion symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)." [GOC:mtg_transport] synonym: "nucleoside (uridine) permease activity" RELATED [] xref: GO:0015394 is_a: CCO:F0001576 ! pyrimidine transmembrane transporter activity is_a: CCO:F0002684 ! uridine transmembrane transporter activity is_a: CCO:F0002815 ! nucleobase:cation symporter activity is_a: CCO:F0002899 ! nucleoside:hydrogen symporter activity [Term] id: CCO:F0002817 name: nucleoside transmembrane transporter activity, down a concentration gradient namespace: molecular_function def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." [PMID:10353709, PMID:11749958, PMID:12446811] synonym: "equilibrative nucleoside transporter" EXACT [] xref: GO:0015395 is_a: CCO:F0001567 ! nucleoside transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002818 name: equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity namespace: molecular_function xref: GO:0015396 is_a: CCO:F0002817 ! nucleoside transmembrane transporter activity, down a concentration gradient [Term] id: CCO:F0002819 name: equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity namespace: molecular_function xref: GO:0015397 is_a: CCO:F0002817 ! nucleoside transmembrane transporter activity, down a concentration gradient [Term] id: CCO:F0002820 name: high affinity secondary active ammonium transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] xref: GO:0015398 is_a: CCO:F0001972 ! ammonium transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002821 name: primary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources." [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-] subset: gosubset_prok synonym: "primary active transporter" RELATED [] xref: GO:0015399 xref: TC:3 is_a: CCO:F0004251 ! active transmembrane transporter activity [Term] id: CCO:F0002822 name: low affinity secondary active ammonium transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "low affinity ammonium transmembrane transporter activity" RELATED [] xref: GO:0015400 is_a: CCO:F0001972 ! ammonium transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002823 name: urea:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1] synonym: "urea active transmembrane transporter activity" EXACT [] xref: GO:0015401 is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0002824 name: thiamin uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of thiamin from the outside of a cell to the inside across a membrane." [GOC:mtg_transport] synonym: "thiamine uptake transporter activity" EXACT [] xref: GO:0015403 is_a: CCO:F0002704 ! thiamin transmembrane transporter activity is_a: CCO:F0002943 ! uptake transmembrane transporter activity [Term] id: CCO:F0002825 name: ion-gradient-driven energizer activity namespace: molecular_function subset: gosubset_prok xref: GO:0015404 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002826 name: P-P-bond-hydrolysis-driven transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.-.-.-] subset: gosubset_prok synonym: "P-P-bond-hydrolysis-driven transporters" EXACT [] xref: GO:0015405 xref: TC:3.A is_a: CCO:F0002821 ! primary active transmembrane transporter activity [Term] id: CCO:F0002827 name: monosaccharide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported." [EC:3.6.3.17] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (monosaccharide-importing)" EXACT [EC:3.6.3.17] synonym: "monosaccharide ABC transporter" NARROW [] synonym: "monosaccharide-importing ATPase activity" NARROW [] xref: EC:3.6.3.17 xref: GO:0015407 xref: MetaCyc:3.6.3.17-RXN is_a: CCO:F0002622 ! monosaccharide transmembrane transporter activity is_a: CCO:F0002971 ! carbohydrate-importing ATPase activity [Term] id: CCO:F0002828 name: ferric-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (ferric-ion-transporting)" EXACT [EC:3.6.3.30] synonym: "Fe3+-transporting ATPase activity" EXACT [EC:3.6.3.30] synonym: "ferric ABC transporter" NARROW [] synonym: "ferric transporting ATPase activity" EXACT [] xref: EC:3.6.3.30 xref: GO:0015408 xref: MetaCyc:3.6.3.30-RXN is_a: CCO:F0002571 ! ferric iron transmembrane transporter activity is_a: CCO:F0004186 ! cation-transporting ATPase activity [Term] id: CCO:F0002829 name: manganese-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [EC:3.6.3.35] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ABC-type manganese permease complex" RELATED [EC:3.6.3.35] synonym: "ATP phosphohydrolase (manganese-importing)" EXACT [EC:3.6.3.35] synonym: "manganese ABC transporter" NARROW [] synonym: "manganese transporting ATPase activity" EXACT [] xref: EC:3.6.3.35 xref: GO:0015410 xref: MetaCyc:3.6.3.35-RXN is_a: CCO:F0001600 ! manganese ion transmembrane transporter activity is_a: CCO:F0004186 ! cation-transporting ATPase activity [Term] id: CCO:F0002830 name: taurine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [EC:3.6.3.36] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (taurine-importing)" EXACT [EC:3.6.3.36] synonym: "taurine (2-aminoethane sulfonate) porter activity" EXACT [] synonym: "taurine ABC transporter" NARROW [] xref: EC:3.6.3.36 xref: GO:0015411 xref: MetaCyc:3.6.3.36-RXN is_a: CCO:F0001594 ! taurine transmembrane transporter activity is_a: CCO:F0002843 ! amino acid-transporting ATPase activity [Term] id: CCO:F0002831 name: molybdate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [EC:3.6.3.29] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (molybdate-importing)" EXACT [EC:3.6.3.29] synonym: "molybdate ABC transporter" NARROW [] synonym: "molybdate porter activity" EXACT [] synonym: "molybdate transporting ATPase activity" EXACT [] synonym: "molybdate-transporting ATPase activity" EXACT [EC:3.6.3.29] xref: EC:3.6.3.29 xref: GO:0015412 xref: MetaCyc:3.6.3.29-RXN is_a: CCO:F0002577 ! molybdate ion transmembrane transporter activity is_a: CCO:F0005824 ! anion transmembrane-transporting ATPase activity [Term] id: CCO:F0002832 name: nickel-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)." [EC:3.6.3.24] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (nickel-importing)" EXACT [EC:3.6.3.24] synonym: "nickel ABC transporter" NARROW [] synonym: "nickel porter activity" EXACT [] synonym: "nickel transporting ATPase activity" EXACT [] xref: EC:3.6.3.24 xref: GO:0015413 xref: MetaCyc:3.6.3.24-RXN is_a: CCO:F0002578 ! nickel ion transmembrane transporter activity is_a: CCO:F0004186 ! cation-transporting ATPase activity [Term] id: CCO:F0002833 name: nitrate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)." [EC:3.6.3.26] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (nitrate-importing)" EXACT [EC:3.6.3.26] synonym: "nitrate ABC transporter" NARROW [] synonym: "nitrate transporting ATPase activity" EXACT [] synonym: "nitrate-transporting ATPase activity" EXACT [EC:3.6.3.26] xref: EC:3.6.3.26 xref: GO:0015414 xref: MetaCyc:3.6.3.26-RXN is_a: CCO:F0002590 ! nitrate transmembrane transporter activity is_a: CCO:F0005824 ! anion transmembrane-transporting ATPase activity [Term] id: CCO:F0002834 name: phosphate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)." [EC:3.6.3.27] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ABC phosphate transporter activity" NARROW [EC:3.6.3.27] synonym: "ATP phosphohydrolase (phosphate-importing)" EXACT [EC:3.6.3.27] synonym: "phosphate ABC transporter" NARROW [] synonym: "phosphate porter activity" EXACT [] synonym: "phosphate transporting ATPase activity" EXACT [] synonym: "phosphate-transporting ATPase activity" EXACT [EC:3.6.3.27] xref: EC:3.6.3.27 xref: GO:0015415 xref: MetaCyc:3.6.3.27-RXN is_a: CCO:F0002592 ! phosphate transmembrane transporter activity is_a: CCO:F0005824 ! anion transmembrane-transporting ATPase activity [Term] id: CCO:F0002835 name: phosphonate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (phosphonate-transporting)" EXACT [EC:3.6.3.28] synonym: "phosphonate ABC transporter" NARROW [] synonym: "phosphonate transporting ATPase activity" EXACT [] synonym: "phosphonate-transporting ATPase activity" EXACT [EC:3.6.3.28] xref: EC:3.6.3.28 xref: GO:0015416 xref: MetaCyc:3.6.3.28-RXN is_a: CCO:F0002967 ! phosphonate transmembrane transporter activity is_a: CCO:F0002968 ! organophosphate ester transmembrane transporter activity is_a: CCO:F0005824 ! anion transmembrane-transporting ATPase activity [Term] id: CCO:F0002836 name: polyamine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (polyamine-importing) activity" EXACT [EC:3.6.3.31] synonym: "polyamine ABC transporter" NARROW [] synonym: "polyamine porter activity" EXACT [] synonym: "polyamine-importing ATPase activity" NARROW [] xref: EC:3.6.3.31 xref: GO:0015417 is_a: CCO:F0002675 ! polyamine transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002837 name: quaternary-ammonium-compound-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (quaternary-amine-importing) activity" EXACT [EC:3.6.3.32] synonym: "glycine betaine/proline porter activity" RELATED [] synonym: "quaternary amine uptake transporter activity" EXACT [] synonym: "quaternary-amine-transporting ATPase activity" EXACT [] synonym: "quaternary-ammonium-compound ABC transporter" NARROW [] xref: EC:3.6.3.32 xref: GO:0015418 xref: MetaCyc:3.6.3.32-RXN is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002838 name: sulfate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)." [EC:3.6.3.25] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (sulfate-importing) activity" EXACT [EC:3.6.3.25] synonym: "sulfate ABC transporter" NARROW [] synonym: "sulfate transporting ATPase activity" EXACT [] synonym: "sulfate-transporting ATPase activity" EXACT [EC:3.6.3.25] synonym: "sulfate/thiosulfate porter activity" EXACT [] synonym: "sulphate transporting ATPase activity" EXACT [] synonym: "sulphate-transporting ATPase activity" EXACT [] xref: EC:3.6.3.25 xref: GO:0015419 xref: MetaCyc:3.6.3.25-RXN is_a: CCO:F0002594 ! sulfate transmembrane transporter activity is_a: CCO:F0005824 ! anion transmembrane-transporting ATPase activity [Term] id: CCO:F0002839 name: cobalamin-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + cobalamin(out) = ADP + phosphate + cobalamin(in). Cobalamin = vitamin B12." [EC:3.6.3.33] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (vitamin B12-importing)" EXACT [EC:3.6.3.33] synonym: "cobalamin ABC transporter" NARROW [] synonym: "cobalamin porter activity" EXACT [] synonym: "vitamin B12 porter activity" EXACT [] synonym: "vitamin B12-transporting ATPase activity" EXACT [] xref: EC:3.6.3.33 xref: GO:0015420 xref: MetaCyc:3.6.3.33-RXN is_a: CCO:F0002705 ! cobalamin transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002840 name: oligopeptide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [EC:3.6.3.23] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (oligopeptide-importing)" EXACT [EC:3.6.3.23] synonym: "oligopeptide ABC transporter" NARROW [] synonym: "oligopeptide permease activity" RELATED [EC:3.6.3.23] xref: EC:3.6.3.23 xref: GO:0015421 xref: MetaCyc:3.6.3.23-RXN is_a: CCO:F0002672 ! oligopeptide transporter activity is_a: CCO:F0002855 ! peptide-transporting ATPase activity [Term] id: CCO:F0002841 name: oligosaccharide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)." [EC:3.6.3.18] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (disaccharide-importing)" EXACT [EC:3.6.3.18] synonym: "oligosaccharide ABC transporter" NARROW [] xref: EC:3.6.3.18 xref: GO:0015422 xref: MetaCyc:3.6.3.18-RXN is_a: CCO:F0002634 ! oligosaccharide transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002842 name: maltose-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)." [EC:3.6.3.19] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (maltose-importing)" EXACT [EC:3.6.3.19] synonym: "maltose ABC transporter" NARROW [] xref: EC:3.6.3.19 xref: GO:0015423 xref: MetaCyc:3.6.3.19-RXN is_a: CCO:F0001589 ! maltose transmembrane transporter activity is_a: CCO:F0002841 ! oligosaccharide-transporting ATPase activity [Term] id: CCO:F0002843 name: amino acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)." [GOC:ai, GOC:mah] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "amino acid ABC transporter" NARROW [] xref: GO:0015424 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity is_a: CCO:F0004647 ! amine-transporting ATPase activity [Term] id: CCO:F0002844 name: nonpolar-amino acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (nonpolar-amino-acid-transporting) activity" EXACT [EC:3.6.3.22] synonym: "leucine/isoleucine/valine porter activity" RELATED [] synonym: "nonpolar amino acid-transporting ATPase activity" EXACT [] synonym: "nonpolar-amino acid ABC transporter" NARROW [] synonym: "nonpolar-amino-acid-transporting ATPase activity" EXACT [] xref: EC:3.6.3.22 xref: GO:0015425 xref: MetaCyc:3.6.3.22-RXN is_a: CCO:F0002843 ! amino acid-transporting ATPase activity [Term] id: CCO:F0002845 name: polar-amino acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (polar-amino-acid-importing) activity" EXACT [EC:3.6.3.21] synonym: "cystine/diaminopimelate porter activity" RELATED [] synonym: "glutamate/aspartate porter activity" RELATED [] synonym: "histidine permease activity" NARROW [EC:3.6.3.21] synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "polar amino acid uptake transporter activity" EXACT [] synonym: "polar amino acid-importing ATPase activity" EXACT [] synonym: "polar-amino acid ABC transporter" NARROW [] synonym: "polar-amino acid-importing ATPase activity" EXACT [] synonym: "polar-amino-acid-transporting ATPase activity" EXACT [EC:3.6.3.21] xref: EC:3.6.3.21 xref: GO:0015426 xref: MetaCyc:3.6.3.21-RXN is_a: CCO:F0002843 ! amino acid-transporting ATPase activity [Term] id: CCO:F0002846 name: glycerol-3-phosphate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)." [EC:3.6.3.20] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (glycerol-3-phosphate-importing)" EXACT [EC:3.6.3.20] synonym: "glycerol-3-phosphate ABC transporter" NARROW [] xref: EC:3.6.3.20 xref: GO:0015430 xref: MetaCyc:3.6.3.20-RXN is_a: CCO:F0002646 ! glycerol-3-phosphate transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002847 name: glutathione S-conjugate-exporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) = ADP + phosphate + glutathione S-conjugate(out)." [GOC:jl, PMID:1455517] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP-dependent glutathione S-conjugate export pump" EXACT [] synonym: "conjugate transporter activity" BROAD [] synonym: "GS-X pump" EXACT [] synonym: "MRP1/GS-X pump" EXACT [] xref: GO:0015431 is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002848 name: bile acid-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O = bile acid(out) + ADP + phosphate." [TC:3.A.1.207.2] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "bile acid porter activity" NARROW [] xref: GO:0015432 is_a: CCO:F0002602 ! bile acid transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002849 name: peptide antigen-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate." [TC:3.A.1.209.1] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "major histocompatibility peptide transporter activity" EXACT [] synonym: "peptide antigen ABC transporter" NARROW [] synonym: "peptide antigen transporter activity" BROAD [] xref: GO:0015433 is_a: CCO:F0002855 ! peptide-transporting ATPase activity [Term] id: CCO:F0002850 name: cadmium-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)." [EC:3.6.3.46] subset: gosubset_prok synonym: "ATP phosphohydrolase (heavy-metal-exporting)" EXACT [EC:3.6.3.46] synonym: "cadmium ABC transporter" NARROW [] synonym: "yeast cadmium factor" RELATED [EC:3.6.3.46] xref: EC:3.6.3.46 xref: GO:0015434 is_a: CCO:F0002566 ! cadmium ion transmembrane transporter activity [Term] id: CCO:F0002851 name: capsular-polysaccharide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)." [EC:3.6.3.38] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (capsular-polysaccharide-exporting)" EXACT [EC:3.6.3.38] synonym: "capsular-polysaccharide ABC transporter" NARROW [] xref: EC:3.6.3.38 xref: GO:0015436 xref: MetaCyc:3.6.3.38-RXN is_a: CCO:F0002638 ! capsular-polysaccharide transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002852 name: lipopolysaccharide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipopolysaccharide(in) = ADP + phosphate + lipopolysaccharide(out)." [EC:3.6.3.39] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (lipopolysaccharide-exporting)" EXACT [EC:3.6.3.39] synonym: "lipopolysaccharide ABC transporter" NARROW [] synonym: "LPS-transporting ATPase activity" EXACT [] xref: EC:3.6.3.39 xref: GO:0015437 xref: MetaCyc:3.6.3.39-RXN is_a: CCO:F0002692 ! lipopolysaccharide transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002853 name: teichoic-acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:3.6.3.40] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (teichoic-acid-exporting)" EXACT [EC:3.6.3.40] synonym: "teichoic-acid ABC transporter" NARROW [] xref: EC:3.6.3.40 xref: GO:0015438 xref: MetaCyc:3.6.3.40-RXN is_a: CCO:F0002639 ! teichoic acid transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002854 name: heme-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (heme-exporting)" EXACT [EC:3.6.3.41] synonym: "haem-transporting ATPase activity" EXACT [] synonym: "heme ABC transporter" NARROW [] xref: EC:3.6.3.41 xref: GO:0015439 xref: MetaCyc:3.6.3.41-RXN is_a: CCO:F0002702 ! heme transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002855 name: peptide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (peptide-exporting)" EXACT [EC:3.6.3.43] synonym: "peptide ABC transporter" NARROW [] xref: EC:3.6.3.43 xref: GO:0015440 xref: MetaCyc:3.6.3.43-RXN is_a: CCO:F0002671 ! peptide transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002856 name: beta-glucan-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)." [EC:3.6.3.42] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (beta-glucan-exporting)" EXACT [EC:3.6.3.42] synonym: "beta-glucan ABC transporter" NARROW [] xref: EC:3.6.3.42 xref: GO:0015441 xref: MetaCyc:3.6.3.42-RXN is_a: CCO:F0002637 ! beta-glucan transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002857 name: magnesium-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in)." [EC:3.6.3.2] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (Mg2+-importing)" EXACT [EC:3.6.3.2] synonym: "magnesium importing ATPase activity" EXACT [] synonym: "magnesium-translocating P-type ATPase activity" RELATED [EC:3.6.3.2] synonym: "Mg(2+)-importing ATPase activity" EXACT [EC:3.6.3.2] synonym: "Mg2+-importing ATPase activity" EXACT [EC:3.6.3.2] synonym: "mg2+-importing ATPase activity" EXACT [EC:3.6.3.2] xref: EC:3.6.3.2 xref: GO:0015444 xref: MetaCyc:3.6.3.2-RXN is_a: CCO:F0002575 ! magnesium ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0002858 name: silver-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) = ADP + phosphate + Ag+(out)." [EC:3.6.3.53] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "Ag+-exporting ATPase activity" EXACT [EC:3.6.3.53] synonym: "ATP phosphohydrolase (Ag+-exporting)" EXACT [EC:3.6.3.53] synonym: "silver exporting ATPase activity" EXACT [] xref: EC:3.6.3.53 xref: GO:0015445 xref: MetaCyc:3.6.3.53-RXN is_a: CCO:F0002561 ! silver ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0002859 name: arsenite transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)." [EC:3.6.3.16] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "arsenical pump-driving ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenical resistance ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenical resistance efflux pump" EXACT [] synonym: "arsenite ABC transporter" NARROW [] synonym: "arsenite transporting ATPase activity" EXACT [] synonym: "arsenite-translocating ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenite-transporting ATPase activity" EXACT [EC:3.6.3.16] synonym: "ATP phosphohydrolase (arsenite-exporting) activity" EXACT [EC:3.6.3.16] xref: EC:3.6.3.16 xref: GO:0015446 xref: MetaCyc:3.6.3.16-RXN is_a: CCO:F0001950 ! arsenite secondary active transmembrane transporter activity is_a: CCO:F0004186 ! cation-transporting ATPase activity is_a: CCO:F0005824 ! anion transmembrane-transporting ATPase activity [Term] id: CCO:F0002860 name: P-P-bond-hydrolysis-driven protein transmembrane transporter activity namespace: molecular_function def: "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "protein translocase activity" EXACT [] xref: GO:0015450 is_a: CCO:F0001832 ! protein transmembrane transporter activity is_a: CCO:F0002826 ! P-P-bond-hydrolysis-driven transmembrane transporter activity is_a: CCO:F0004305 ! macromolecule transmembrane transporter activity [Term] id: CCO:F0002861 name: decarboxylation-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-] subset: gosubset_prok synonym: "Decarboxylation-driven transporters" RELATED [] xref: GO:0015451 xref: TC:3.B is_a: CCO:F0002821 ! primary active transmembrane transporter activity [Term] id: CCO:F0002862 name: methyl transfer-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-] synonym: "Methyltransfer-driven transporters" EXACT [] xref: GO:0015452 xref: TC:3.C is_a: CCO:F0002821 ! primary active transmembrane transporter activity [Term] id: CCO:F0002863 name: oxidoreduction-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-] subset: gosubset_prok synonym: "Oxidoreduction-driven transporters" EXACT [] xref: GO:0015453 xref: TC:3.D is_a: CCO:F0002821 ! primary active transmembrane transporter activity [Term] id: CCO:F0002864 name: light-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-] synonym: "Light absorption-driven transporters" EXACT [] synonym: "light-driven pumps" EXACT [] xref: GO:0015454 xref: TC:3.E is_a: CCO:F0002821 ! primary active transmembrane transporter activity [Term] id: CCO:F0002865 name: auxiliary transport protein activity namespace: molecular_function def: "Facilitates transport across one or more biological membranes but do not themselves participate directly in transport. These proteins always function in conjunction with one or more established transport systems. They may provide a function connected with energy coupling to transport, play a structural role in complex formation, serve a biogenic or stability function or function in regulation." [TC:8.A.-.-.-] subset: goslim_pir subset: gosubset_prok xref: GO:0015457 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0002866 name: low voltage-gated potassium channel auxiliary protein activity namespace: molecular_function synonym: "low voltage-dependent potassium channel auxiliary protein activity" EXACT [] xref: GO:0015458 is_a: CCO:F0002865 ! auxiliary transport protein activity [Term] id: CCO:F0002867 name: potassium channel regulator activity namespace: molecular_function xref: GO:0015459 is_a: CCO:F0003086 ! channel regulator activity [Term] id: CCO:F0002868 name: transport accessory protein activity namespace: molecular_function xref: GO:0015460 is_a: CCO:F0002865 ! auxiliary transport protein activity [Term] id: CCO:F0002869 name: protein-transmembrane transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "pilin/fimbrilin exporter activity" NARROW [] synonym: "protein ABC transporter" NARROW [] synonym: "protein-transporting ATPase activity" EXACT [] xref: GO:0015462 is_a: CCO:F0002860 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002870 name: acetylcholine receptor activity namespace: molecular_function def: "Combining with acetylcholine to initiate a change in cell activity." [GOC:jl] xref: GO:0015464 is_a: CCO:F0001240 ! transmembrane receptor activity is_a: CCO:F0004488 ! neurotransmitter receptor activity is_a: CCO:F0005634 ! acetylcholine binding [Term] id: CCO:F0002871 name: G-protein activated inward rectifier potassium channel activity namespace: molecular_function synonym: "G protein activated inward rectifier potassium channel activity" EXACT [] synonym: "G-protein-activated inward rectifier potassium channel activity" EXACT [] xref: GO:0015467 is_a: CCO:F0001510 ! inward rectifier potassium channel activity [Term] id: CCO:F0002872 name: nucleoside-specific channel forming porin activity namespace: molecular_function def: "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] xref: GO:0015471 is_a: CCO:F0002739 ! porin activity [Term] id: CCO:F0002873 name: fimbrial usher porin activity namespace: molecular_function def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-] xref: GO:0015473 is_a: CCO:F0002739 ! porin activity [Term] id: CCO:F0002874 name: autotransporter activity namespace: molecular_function def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-] subset: gosubset_prok xref: GO:0015474 is_a: CCO:F0001997 ! protein transporter activity is_a: CCO:F0002739 ! porin activity [Term] id: CCO:F0002875 name: adhesin autotransporter activity namespace: molecular_function def: "Catalysis of the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0015475 is_a: CCO:F0002874 ! autotransporter activity [Term] id: CCO:F0002876 name: hemaglutinin autotransporter activity namespace: molecular_function def: "Catalysis of the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0015476 is_a: CCO:F0002874 ! autotransporter activity [Term] id: CCO:F0002877 name: oligosaccharide transporting porin activity namespace: molecular_function def: "Catalysis of the transfer of oligosaccharide, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] synonym: "raffinose porin" NARROW [] xref: GO:0015478 is_a: CCO:F0002634 ! oligosaccharide transmembrane transporter activity is_a: CCO:F0002739 ! porin activity [Term] id: CCO:F0002878 name: maltose transporting porin activity namespace: molecular_function def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] subset: gosubset_prok synonym: "maltoporin" EXACT [] xref: GO:0015481 is_a: CCO:F0001589 ! maltose transmembrane transporter activity is_a: CCO:F0002739 ! porin activity [Term] id: CCO:F0002879 name: long-chain fatty acid transporting porin activity namespace: molecular_function def: "Catalysis of the transfer of long-chain fatty acids from one side of the membrane to the other. Long-chain fatty acids have a chain length of greater than 12 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] xref: GO:0015483 is_a: CCO:F0001557 ! long-chain fatty acid transporter activity is_a: CCO:F0002739 ! porin activity [Term] id: CCO:F0002880 name: cholesterol binding namespace: molecular_function def: "Interacting selectively with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0015485 is_a: CCO:F0005049 ! sterol binding [Term] id: CCO:F0002881 name: glycoside-pentoside-hexuronide:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-] xref: GO:0015486 is_a: CCO:F0001605 ! cation:sugar symporter activity [Term] id: CCO:F0002882 name: melibiose:monovalent cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)." [TC:2.A.2.1.1] subset: gosubset_prok synonym: "melibiose permease activity" RELATED [] xref: GO:0015487 is_a: CCO:F0002633 ! melibiose transmembrane transporter activity is_a: CCO:F0002881 ! glycoside-pentoside-hexuronide:cation symporter activity [Term] id: CCO:F0002883 name: glucuronide:monovalent cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1] synonym: "glucuronoside permease activity" RELATED [] xref: GO:0015488 is_a: CCO:F0002641 ! glucuronoside transmembrane transporter activity is_a: CCO:F0002881 ! glycoside-pentoside-hexuronide:cation symporter activity [Term] id: CCO:F0002884 name: putrescine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of putrescine from one side of the membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] subset: gosubset_prok xref: GO:0015489 is_a: CCO:F0002675 ! polyamine transmembrane transporter activity [Term] id: CCO:F0002885 name: cadaverine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cadaverine, 1,5-pentanediamine, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015490 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0002886 name: cation:cation antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai] subset: gosubset_prok xref: GO:0015491 is_a: CCO:F0002747 ! solute:cation antiporter activity [Term] id: CCO:F0002887 name: phenylalanine:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1] synonym: "phenylalanine:proton symporter" EXACT [] xref: GO:0015492 is_a: CCO:F0002666 ! L-phenylalanine transmembrane transporter activity is_a: CCO:F0002889 ! aromatic amino acid:hydrogen symporter activity [Term] id: CCO:F0002888 name: lysine:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2] synonym: "lysine:proton symporter" EXACT [] xref: GO:0015493 is_a: CCO:F0001533 ! hydrogen:amino acid symporter activity is_a: CCO:F0002663 ! L-lysine transmembrane transporter activity [Term] id: CCO:F0002889 name: aromatic amino acid:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3] synonym: "aromatic amino acid:proton symporter" EXACT [] xref: GO:0015494 is_a: CCO:F0001533 ! hydrogen:amino acid symporter activity is_a: CCO:F0002650 ! aromatic amino acid transmembrane transporter activity [Term] id: CCO:F0002890 name: gamma-aminobutyric acid:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2] comment: See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'. synonym: "4-aminobutanoate:hydrogen symporter activity" EXACT [] synonym: "4-aminobutanoate:proton symporter activty" EXACT [] synonym: "4-aminobutyrate:hydrogen symporter activity" EXACT [] synonym: "4-aminobutyrate:proton symporter activity" EXACT [] synonym: "GABA:hydrogen symporter activity" EXACT [] synonym: "GABA:proton symporter activity" EXACT [] synonym: "gamma-aminobutyric acid permease activity" EXACT [] synonym: "gamma-aminobutyric acid:proton symporter" EXACT [] xref: GO:0005331 xref: GO:0015329 xref: GO:0015495 is_a: CCO:F0001533 ! hydrogen:amino acid symporter activity is_a: CCO:F0002659 ! L-gamma-aminobutyric acid transmembrane transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0002891 name: putrescine:ornithine antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)." [TC:2.A.3.2.1] subset: gosubset_prok synonym: "putrescine-ornithine antiporter activity" EXACT [] synonym: "putrescine/ornithine antiporter activity" EXACT [] synonym: "putrescine:hydrogen symporter" EXACT [] xref: GO:0015496 is_a: CCO:F0000017 ! L-ornithine transmembrane transporter activity is_a: CCO:F0002749 ! solute:solute antiporter activity is_a: CCO:F0002884 ! putrescine transmembrane transporter activity [Term] id: CCO:F0002892 name: cadaverine:lysine antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cadaverine(out) + lysine(in) = cadaverine(in) + lysine(out)." [TC:2.A.3.2.2] subset: gosubset_prok xref: GO:0015497 is_a: CCO:F0002663 ! L-lysine transmembrane transporter activity is_a: CCO:F0002749 ! solute:solute antiporter activity is_a: CCO:F0002885 ! cadaverine transmembrane transporter activity [Term] id: CCO:F0002893 name: pantothenate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1] subset: gosubset_prok xref: GO:0015498 is_a: CCO:F0002703 ! pantothenate transporter activity is_a: CCO:F0002797 ! solute:sodium symporter activity [Term] id: CCO:F0002894 name: formate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai] subset: gosubset_prok xref: GO:0015499 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002895 name: glutamate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1] synonym: "sodium/excitatory glutamate cotransporter activity" EXACT [] synonym: "sodium/excitatory glutamate symporter activity" EXACT [] xref: GO:0008027 xref: GO:0015501 is_a: CCO:F0001534 ! sodium:amino acid symporter activity is_a: CCO:F0001552 ! L-glutamate transmembrane transporter activity [Term] id: CCO:F0002896 name: glutathione-regulated potassium exporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2] subset: gosubset_prok xref: GO:0015503 is_a: CCO:F0002560 ! potassium ion transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002897 name: cytosine:hydrogen ion symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1] synonym: "cytosine permease activity" RELATED [] xref: GO:0015504 is_a: CCO:F0002680 ! cytosine transmembrane transporter activity is_a: CCO:F0002815 ! nucleobase:cation symporter activity [Term] id: CCO:F0002898 name: uracil:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [GOC:mtg_transport] subset: gosubset_prok synonym: "uracil permease activity" RELATED [] xref: GO:0015505 is_a: CCO:F0002681 ! uracil transmembrane transporter activity is_a: CCO:F0002815 ! nucleobase:cation symporter activity [Term] id: CCO:F0002899 name: nucleoside:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)." [TC:2.A.1.10.1, TC:2.A.41.1.1] synonym: "nucleoside permease activity" RELATED [] synonym: "nucleoside:hydrogen ion symporter activity" EXACT [] synonym: "nucleoside:proton symporter" EXACT [] xref: GO:0015506 xref: GO:0015536 is_a: CCO:F0001567 ! nucleoside transmembrane transporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity [Term] id: CCO:F0002900 name: nitrite uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrite from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "nitrite uptake permease activity" EXACT [] xref: GO:0015513 is_a: CCO:F0002591 ! nitrite transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity is_a: CCO:F0002943 ! uptake transmembrane transporter activity [Term] id: CCO:F0002901 name: nitrite efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "nitrite extrusion permease activity" EXACT [] xref: GO:0015514 is_a: CCO:F0002591 ! nitrite transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity is_a: CCO:F0002942 ! efflux transmembrane transporter activity [Term] id: CCO:F0002902 name: citrate:succinate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2] subset: gosubset_prok xref: GO:0015515 is_a: CCO:F0002614 ! citrate transmembrane transporter activity is_a: CCO:F0002618 ! succinate transmembrane transporter activity is_a: CCO:F0002750 ! anion:anion antiporter activity [Term] id: CCO:F0002903 name: tartrate:succinate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3] xref: GO:0015516 is_a: CCO:F0002618 ! succinate transmembrane transporter activity is_a: CCO:F0002750 ! anion:anion antiporter activity is_a: CCO:F0002935 ! tartrate transmembrane transporter activity [Term] id: CCO:F0002904 name: galactose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9] subset: gosubset_prok synonym: "galactose:proton symporter" EXACT [] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] xref: GO:0015517 is_a: CCO:F0001580 ! galactose transmembrane transporter activity is_a: CCO:F0002404 ! hexose:hydrogen symporter activity [Term] id: CCO:F0002905 name: arabinose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)." [TC:2.A.1.1.2] synonym: "arabinose:proton symporter" EXACT [] xref: GO:0015518 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0005736 ! arabinose transmembrane transporter activity [Term] id: CCO:F0002906 name: D-xylose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3] subset: gosubset_prok synonym: "D-xylose:proton symporter" EXACT [] xref: GO:0015519 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002625 ! D-xylose transmembrane transporter activity [Term] id: CCO:F0002907 name: tetracycline:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)." [TC:2.A.1.2.4] subset: gosubset_prok synonym: "tetracyclin:hydrogen antiporter activity" EXACT [] synonym: "tetracyclin:proton antiporter activity" EXACT [] synonym: "tetracycline:proton antiporter" EXACT [] xref: GO:0015520 is_a: CCO:F0001951 ! tetracycline transporter activity is_a: CCO:F0002753 ! drug:hydrogen antiporter activity [Term] id: CCO:F0002908 name: hydrophobic uncoupler:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS." [TC:2.A.1.2.9] synonym: "hydrophobic uncoupler:proton antiporter" EXACT [] xref: GO:0015522 is_a: CCO:F0002753 ! drug:hydrogen antiporter activity is_a: CCO:F0003549 ! oxidative phosphorylation uncoupler activity [Term] id: CCO:F0002909 name: arabinose efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arabinose from the inside of the cell to the outside of the cell across a membrane: H+(out) + arabinose(in) = H+(in) + arabinose(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.2.14] synonym: "arabinose efflux permease activity" EXACT [] xref: GO:0015523 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002942 ! efflux transmembrane transporter activity is_a: CCO:F0005736 ! arabinose transmembrane transporter activity [Term] id: CCO:F0002910 name: hexose-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.1] xref: GO:0015526 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002597 ! hexose phosphate transmembrane transporter activity is_a: CCO:F0002761 ! organophosphate:inorganic phosphate antiporter activity [Term] id: CCO:F0002911 name: glycerol-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3] xref: GO:0015527 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002646 ! glycerol-3-phosphate transmembrane transporter activity is_a: CCO:F0002761 ! organophosphate:inorganic phosphate antiporter activity [Term] id: CCO:F0002912 name: lactose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] synonym: "lactose:proton symporter" EXACT [] xref: GO:0015528 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002632 ! lactose transmembrane transporter activity [Term] id: CCO:F0002913 name: raffinose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2] synonym: "raffinose:proton symporter" EXACT [] xref: GO:0015529 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002635 ! raffinose transmembrane transporter activity [Term] id: CCO:F0002914 name: shikimate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of shikimate from one side of the membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:ai] subset: gosubset_prok xref: GO:0015530 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002915 name: citrate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1] synonym: "citrate:proton symporter" EXACT [] xref: GO:0015531 is_a: CCO:F0002614 ! citrate transmembrane transporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity [Term] id: CCO:F0002916 name: alpha-ketoglutarate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)." [TC:2.A.1.6.2] subset: gosubset_prok synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT [] synonym: "2-oxoglutarate:proton symporter" EXACT [] synonym: "alpha-ketoglutarate:proton symporter" EXACT [] xref: GO:0015532 is_a: CCO:F0002616 ! alpha-ketoglutarate transmembrane transporter activity is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0002917 name: shikimate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6] synonym: "shikimate:proton symporter" EXACT [] xref: GO:0015533 is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0002745 ! anion:cation symporter activity is_a: CCO:F0002914 ! shikimate transmembrane transporter activity [Term] id: CCO:F0002918 name: fucose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)." [TC:2.A.1.7.1] synonym: "fucose:proton symporter" EXACT [] xref: GO:0015535 is_a: CCO:F0002404 ! hexose:hydrogen symporter activity is_a: CCO:F0002627 ! fucose transmembrane transporter activity [Term] id: CCO:F0002919 name: xanthosine:hydrogen ion symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2] synonym: "xanthosine permease activity" RELATED [] xref: GO:0015537 is_a: CCO:F0002899 ! nucleoside:hydrogen symporter activity is_a: CCO:F0002934 ! xanthosine transmembrane transporter activity [Term] id: CCO:F0002920 name: sialic acid:hydrogen ion symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)." [TC:2.A.1.12.1] subset: gosubset_prok synonym: "sialic acid permease activity" RELATED [] xref: GO:0015538 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002613 ! sialic acid transmembrane transporter activity [Term] id: CCO:F0002921 name: hexuronate:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate." [TC:2.A.1.14.2] synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW [] synonym: "hexuronate porter activity" RELATED [] xref: GO:0015539 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002611 ! hexuronate transmembrane transporter activity [Term] id: CCO:F0002922 name: 3-hydroxyphenyl propionate:hydrogen ion symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2] synonym: "3-hydroxyphenyl propionate porter activity" RELATED [] xref: GO:0015540 is_a: CCO:F0002742 ! symporter activity is_a: CCO:F0002932 ! 3-hydroxyphenyl propanoate transmembrane transporter activity [Term] id: CCO:F0002923 name: secondary active cyanate uptake transmembrane transporter namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cyanate(out) = cyanate(in)." [TC:2.A.1.17.1] synonym: "cyanate porter activity" RELATED [] xref: GO:0015541 is_a: CCO:F0002588 ! cyanate transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002924 name: sugar efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(in) = sugar(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.20.1] subset: gosubset_prok synonym: "lactose/glucose efflux transporter activity" NARROW [] xref: GO:0015542 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity [Term] id: CCO:F0002925 name: phenyl propionate uptake uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenyl propionate(out) = phenyl propionate(in)." [GOC:mtg_transport, TC:2.A.1.27.1] synonym: "phenyl propionate permease activity" RELATED [] xref: GO:0015544 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity is_a: CCO:F0002933 ! propionate transmembrane transporter activity [Term] id: CCO:F0002926 name: bicyclomycin transporter activity namespace: molecular_function def: "Enables the directed movement of bicyclomycin into, out of, within or between cells. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X] subset: gosubset_prok synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW [] xref: GO:0015545 is_a: CCO:F0005732 ! antibiotic transporter activity [Term] id: CCO:F0002927 name: sulfathiazole transporter activity namespace: molecular_function def: "Enables the directed movement of sulfathiazole into, out of, within or between cells. Sulfathiazole is an antibacterial agent of the sulfonamide group." [http://cancerweb.ncl.ac.uk/] synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW [] synonym: "sulphathiazole transporter activity" EXACT [] xref: GO:0015546 is_a: CCO:F0006070 ! azole transporter activity [Term] id: CCO:F0002928 name: nalidixic acid transporter activity namespace: molecular_function def: "Enables the directed movement of nalidixic acid into, out of, within or between cells. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [http://cancerweb.ncl.ac.uk/] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] xref: GO:0015547 is_a: CCO:F0005732 ! antibiotic transporter activity is_a: CCO:F0005740 ! xenobiotic transporter activity [Term] id: CCO:F0002929 name: organomercurial transporter activity namespace: molecular_function def: "Enables the directed movement of organomercurial compounds into, out of, within or between cells. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] xref: GO:0015548 is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0002930 name: carbonyl cyanide m-chlorophenylhydrazone transporter activity namespace: molecular_function def: "Enables the directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of, within or between cells. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [http://cancerweb.ncl.ac.uk/] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] synonym: "CCCP transporter" EXACT [] xref: GO:0015549 is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0002931 name: galacturonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of galacturonate from one side of the membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] xref: GO:0015550 is_a: CCO:F0002611 ! hexuronate transmembrane transporter activity [Term] id: CCO:F0002932 name: 3-hydroxyphenyl propanoate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of 3-hydroxyphenyl propanoate from one side of the membrane to the other." [GOC:ai] synonym: "3-hydroxyphenyl propionate transmembrane transporter activity" EXACT [] xref: GO:0015551 is_a: CCO:F0002933 ! propionate transmembrane transporter activity [Term] id: CCO:F0002933 name: propionate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of propionate from one side of the membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." [GOC:ai] xref: GO:0015552 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002934 name: xanthosine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015553 is_a: CCO:F0002682 ! purine nucleoside transmembrane transporter activity [Term] id: CCO:F0002935 name: tartrate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tartrate from one side of the membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria." [GOC:ai] subset: gosubset_prok xref: GO:0015554 is_a: CCO:F0001551 ! dicarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002936 name: acriflavin resistant pump activity namespace: molecular_function xref: GO:0015555 is_a: CCO:F0002946 ! acriflavin transporter activity [Term] id: CCO:F0002937 name: C4-dicarboxylate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of C4-dicarboxylate from one side of the membrane to the other." [GOC:krc] subset: gosubset_prok xref: GO:0015556 is_a: CCO:F0001551 ! dicarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002938 name: arginine targeting transmembrane transporter activity namespace: molecular_function xref: GO:0015557 is_a: CCO:F0001997 ! protein transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0002939 name: p-aminobenzoyl-glutamate uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of p-aminobenzoyl-glutamate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "p-aminobenzoyl-glutamate uptake permease activity" EXACT [] xref: GO:0015558 is_a: CCO:F0002943 ! uptake transmembrane transporter activity is_a: CCO:F0002949 ! p-aminobenzoyl-glutamate transmembrane transporter activity [Term] id: CCO:F0002940 name: multidrug efflux pump activity namespace: molecular_function subset: gosubset_prok xref: GO:0015559 is_a: CCO:F0002707 ! multidrug transporter activity [Term] id: CCO:F0002941 name: rhamnose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)." [TC:2.A.7.6.1] synonym: "rhamnose:proton symporter" EXACT [] xref: GO:0015561 is_a: CCO:F0002404 ! hexose:hydrogen symporter activity is_a: CCO:F0002630 ! rhamnose transmembrane transporter activity [Term] id: CCO:F0002942 name: efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "efflux permease activity" EXACT [] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] xref: GO:0015562 is_a: CCO:F0004284 ! transmembrane transporter activity [Term] id: CCO:F0002943 name: uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a specific substance or related group of substances from the outside of a cell to the inside across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "cobalt, zinc uptake permease activity" NARROW [] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] synonym: "uptake permease activity" RELATED [] synonym: "zinc, cadmium uptake permease activity" NARROW [] synonym: "zinc, iron permease activity" NARROW [] xref: GO:0015563 is_a: CCO:F0004284 ! transmembrane transporter activity [Term] id: CCO:F0002944 name: multidrug, alkane resistant pump activity namespace: molecular_function xref: GO:0015564 is_a: CCO:F0002707 ! multidrug transporter activity is_a: CCO:F0002947 ! alkane transporter activity [Term] id: CCO:F0002945 name: threonine efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of threonine from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "threonine efflux permease activity" EXACT [] synonym: "threonine export protein" RELATED [] synonym: "threonine export transporter activity" EXACT [] xref: GO:0015565 is_a: CCO:F0002669 ! L-threonine transmembrane transporter activity is_a: CCO:F0002942 ! efflux transmembrane transporter activity [Term] id: CCO:F0002946 name: acriflavin transporter activity namespace: molecular_function def: "Enables the directed movement of acriflavin into, out of, within or between cells. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [http://cancerweb.ncl.ac.uk/] xref: GO:0015566 is_a: CCO:F0002706 ! drug transporter activity is_a: CCO:F0005740 ! xenobiotic transporter activity [Term] id: CCO:F0002947 name: alkane transporter activity namespace: molecular_function def: "Enables the directed movement of alkanes into, out of, within or between cells. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] xref: GO:0015567 is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0002948 name: L-idonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-idonate from one side of the membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai] subset: gosubset_prok synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] xref: GO:0015568 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0002949 name: p-aminobenzoyl-glutamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid." [GOC:ai] subset: gosubset_prok synonym: "p-aminobenzoyl-glutamate transporter activity" BROAD [] xref: GO:0015569 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0002950 name: energizer of outer membrane receptor-mediated transport activity namespace: molecular_function xref: GO:0015570 is_a: CCO:F0002825 ! ion-gradient-driven energizer activity [Term] id: CCO:F0002951 name: N-acetylgalactosamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "N-acetylgalactosamine permease activity" EXACT [] xref: GO:0015571 xref: GO:0015590 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0002952 name: N-acetylglucosamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of N-acetylglucosamine from one side of the membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-GlcNAc transmembrane transporter activity" EXACT [] synonym: "N-Acetyl-D-glucosamine permease" RELATED [] synonym: "N-acetyl-D-glucosamine transmembrane transporter activity" EXACT [] synonym: "N-acetylchitosamine transmembrane transporter activity" EXACT [] synonym: "N-acetylglucosamine permease activity" RELATED [] xref: GO:0015572 xref: GO:0015580 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0002953 name: beta-glucoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of beta-glucosides from one side of the membrane to the other. Beta-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "beta-glucoside permease activity" EXACT [] xref: GO:0015573 xref: GO:0015582 is_a: CCO:F0005760 ! glucoside transmembrane transporter activity [Term] id: CCO:F0002954 name: trehalose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "trehalose permease activity" EXACT [] xref: GO:0015574 xref: GO:0015584 is_a: CCO:F0002628 ! alpha-glucoside transmembrane transporter activity is_a: CCO:F0002631 ! disaccharide transmembrane transporter activity [Term] id: CCO:F0002955 name: mannitol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of mannitol from one side of the membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "mannitol permease activity" EXACT [] xref: GO:0015575 xref: GO:0015586 is_a: CCO:F0002643 ! polyol transmembrane transporter activity [Term] id: CCO:F0002956 name: sorbitol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sorbitol from one side of the membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucitol permease activity" EXACT [] synonym: "glucitol transporter activity" EXACT [] synonym: "sorbitol permease activity" EXACT [] xref: GO:0015576 xref: GO:0015587 is_a: CCO:F0002643 ! polyol transmembrane transporter activity [Term] id: CCO:F0002957 name: galactitol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a galactitol from one side of the membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "galactitol permease activity" EXACT [] xref: GO:0015577 xref: GO:0015588 is_a: CCO:F0002643 ! polyol transmembrane transporter activity [Term] id: CCO:F0002958 name: mannose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of mannose from one side of the membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "mannose permease activity" EXACT [] xref: GO:0015578 xref: GO:0015589 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0002959 name: D-ribose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-ribose from one side of the membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok xref: GO:0015591 is_a: CCO:F0002623 ! pentose transmembrane transporter activity [Term] id: CCO:F0002960 name: methylgalactoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of methylgalactoside from one side of the membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729] subset: gosubset_prok synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] xref: GO:0015592 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0002961 name: allose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of allose from one side of the membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0015593 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0002962 name: putrescine-importing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + putrescine(out) = ADP + phosphate + putrescine(in)." [EC:3.6.3.31] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "putrescine porter activity" BROAD [] xref: GO:0015594 is_a: CCO:F0002836 ! polyamine-transporting ATPase activity is_a: CCO:F0002884 ! putrescine transmembrane transporter activity [Term] id: CCO:F0002963 name: spermidine-importing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + spermidine(out) = ADP + phosphate + spermidine(in)." [EC:3.6.3.31] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "spermidine porter activity" BROAD [] xref: GO:0015595 is_a: CCO:F0002836 ! polyamine-transporting ATPase activity is_a: CCO:F0002969 ! spermidine transmembrane transporter activity [Term] id: CCO:F0002964 name: arginine-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arginine(out) = ADP + phosphate + arginine(in)." [EC:3.6.3.21] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "arginine porter activity" EXACT [] xref: GO:0015598 is_a: CCO:F0002655 ! arginine transmembrane transporter activity is_a: CCO:F0002845 ! polar-amino acid-transporting ATPase activity [Term] id: CCO:F0002965 name: glutamine-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) = ADP + phosphate + glutamine(in)." [EC:3.6.3.21] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "glutamine porter activity" BROAD [] xref: GO:0015599 is_a: CCO:F0002660 ! L-glutamine transmembrane transporter activity is_a: CCO:F0002845 ! polar-amino acid-transporting ATPase activity [Term] id: CCO:F0002966 name: iron chelate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com] subset: gosubset_prok xref: GO:0015603 is_a: CCO:F0001599 ! iron ion transmembrane transporter activity [Term] id: CCO:F0002967 name: phosphonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphonate from one side of a membrane to the other. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:ai] subset: gosubset_prok xref: GO:0015604 is_a: CCO:F0001967 ! organic anion transmembrane transporter activity [Term] id: CCO:F0002968 name: organophosphate ester transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] xref: GO:0015605 is_a: CCO:F0001967 ! organic anion transmembrane transporter activity [Term] id: CCO:F0002969 name: spermidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015606 is_a: CCO:F0002675 ! polyamine transmembrane transporter activity [Term] id: CCO:F0002970 name: fatty acyl CoA transporter activity namespace: molecular_function def: "Enables the directed movement of a fatty acyl CoA group into, out of, within or between cells. A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A moiety attached to it." [GOC:ai] xref: GO:0015607 is_a: CCO:F0002714 ! fatty acyl transporter activity [Term] id: CCO:F0002971 name: carbohydrate-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) = ADP + phosphate + carbohydrate(in)." [GOC:ai, TC:3.A.1.1.-, TC:3.A.1.2.-] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "carbohydrate uptake transporter activity" EXACT [] synonym: "sugar transporter" NARROW [] xref: GO:0015608 is_a: CCO:F0005819 ! carbohydrate-transporting ATPase activity [Term] id: CCO:F0002972 name: maltooligosaccharide-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltooligosaccharide(out) = ADP + phosphate + maltooligosaccharide(in)." [TC:3.A.1.-.-] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "maltooligosaccharide porter activity" BROAD [] xref: GO:0015609 is_a: CCO:F0002634 ! oligosaccharide transmembrane transporter activity is_a: CCO:F0002971 ! carbohydrate-importing ATPase activity [Term] id: CCO:F0002973 name: glycerol phosphate-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-phosphate(out) = ADP + phosphate + glycerol-phosphate(in)." [TC:3.A.1.-.-] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "glycerol-phosphate porter activity" BROAD [] xref: GO:0015610 is_a: CCO:F0002646 ! glycerol-3-phosphate transmembrane transporter activity is_a: CCO:F0002971 ! carbohydrate-importing ATPase activity [Term] id: CCO:F0002974 name: D-ribose-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) = ADP + phosphate + D-ribose(in)." [TC:3.A.1.-.-] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "D-ribose porter activity" BROAD [] xref: GO:0015611 is_a: CCO:F0002827 ! monosaccharide-transporting ATPase activity is_a: CCO:F0002959 ! D-ribose transmembrane transporter activity [Term] id: CCO:F0002975 name: L-arabinose-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) = ADP + phosphate + L-arabinose(in)." [TC:3.A.1.-.-] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "L-arabinose porter activity" EXACT [] xref: GO:0015612 is_a: CCO:F0002624 ! L-arabinose transmembrane transporter activity is_a: CCO:F0002827 ! monosaccharide-transporting ATPase activity [Term] id: CCO:F0002976 name: D-xylose-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in)." [TC:3.A.1.-.-] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "D-xylose porter activity" BROAD [] xref: GO:0015614 is_a: CCO:F0002625 ! D-xylose transmembrane transporter activity is_a: CCO:F0002827 ! monosaccharide-transporting ATPase activity [Term] id: CCO:F0002977 name: D-allose-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) = ADP + phosphate + D-allose(in)." [TC:3.A.1.-.-] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "D-allose porter activity" BROAD [] xref: GO:0015615 is_a: CCO:F0002961 ! allose transmembrane transporter activity is_a: CCO:F0002971 ! carbohydrate-importing ATPase activity [Term] id: CCO:F0002978 name: DNA translocase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive movement along a single- or double-stranded DNA molecule." [GOC:mah, PMID:16428451, PMID:17631491] comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. xref: GO:0015616 is_a: CCO:F0000274 ! DNA binding is_a: CCO:F0001707 ! DNA-dependent ATPase activity [Term] id: CCO:F0002979 name: thiamin pyrophosphate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamin pyrophosphate(out) = ADP + phosphate + thiamin pyrophosphate(in)." [TC:3.A.1.19.1] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "thiamin pyrophosphate ABC transporter" NARROW [] synonym: "thiamin pyrophosphate porter activity" BROAD [] synonym: "thiamine pyrophosphate transporting ATPase activity" EXACT [] synonym: "TPP transporting ATPase activity" EXACT [] xref: GO:0015619 is_a: CCO:F0002704 ! thiamin transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002980 name: ferric-enterobactin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric-enterobactin from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015620 is_a: CCO:F0002777 ! siderophore-iron transmembrane transporter activity [Term] id: CCO:F0002981 name: ferric triacetylfusarinine C transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric triacetylfusarinine C from one side of a membrane to the other." [GOC:ai] xref: GO:0015621 is_a: CCO:F0002571 ! ferric iron transmembrane transporter activity [Term] id: CCO:F0002982 name: ferric-hydroxamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric-hydroxamate from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015622 is_a: CCO:F0002777 ! siderophore-iron transmembrane transporter activity [Term] id: CCO:F0002983 name: iron-chelate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + iron chelate(out) = ADP + phosphate + iron chelate(in). Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores are imported." [EC:3.6.3.34] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (iron-chelate-importing)" EXACT [EC:3.6.3.34] synonym: "ferric/ferric-dicitrate porter" BROAD [] synonym: "iron-chelate ABC transporter" NARROW [] xref: EC:3.6.3.34 xref: GO:0015409 xref: GO:0015623 xref: MetaCyc:3.6.3.34-RXN is_a: CCO:F0002966 ! iron chelate transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0002984 name: ferric-enterobactin-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)." [TC:3.A.1.-.-] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ferric-enterobactin ABC transporter" NARROW [] synonym: "ferric-enterobactin porter activity" BROAD [] xref: GO:0015624 is_a: CCO:F0002980 ! ferric-enterobactin transmembrane transporter activity is_a: CCO:F0002983 ! iron-chelate-transporting ATPase activity [Term] id: CCO:F0002985 name: ferric-hydroxamate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)." [TC:3.A.1.-.-] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ferric-hydroxamate ABC transporter" NARROW [] synonym: "ferric-hydroxamate porter activity" BROAD [] xref: GO:0015625 is_a: CCO:F0002982 ! ferric-hydroxamate transmembrane transporter activity is_a: CCO:F0002983 ! iron-chelate-transporting ATPase activity [Term] id: CCO:F0002986 name: L-diaminopimelate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the levorotatory isomer anion of 2,6-diaminoheptanedioic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] synonym: "cystine/diaminopimelate porter activity" NARROW [] synonym: "L-diaminopimelate transporter activity" BROAD [] xref: GO:0015626 is_a: CCO:F0002653 ! L-amino acid transmembrane transporter activity [Term] id: CCO:F0002987 name: tubulin binding namespace: molecular_function def: "Interacting selectively with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] xref: GO:0015631 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0002988 name: zinc transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)." [TC:3.A.1.-.-] synonym: "zinc porter activity" RELATED [] xref: GO:0015633 is_a: CCO:F0001601 ! zinc ion transmembrane transporter activity [Term] id: CCO:F0002989 name: lipopolysaccharide exporter activity namespace: molecular_function def: "Catalysis of the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:mtg_transport, ISBN:0815340729] synonym: "LPS exporter activity" EXACT [] xref: GO:0015634 is_a: CCO:F0002692 ! lipopolysaccharide transmembrane transporter activity is_a: CCO:F0002942 ! efflux transmembrane transporter activity [Term] id: CCO:F0002990 name: short-chain fatty acid transporter activity namespace: molecular_function def: "Enables the directed movement of short-chain fatty acids into, out of, within or between cells. Short-chain fatty acids have a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015635 is_a: CCO:F0002713 ! fatty acid transporter activity [Term] id: CCO:F0002991 name: short-chain fatty acid uptake transporter activity namespace: molecular_function xref: GO:0015636 is_a: CCO:F0002990 ! short-chain fatty acid transporter activity [Term] id: CCO:F0002992 name: microcin uptake permease activity namespace: molecular_function subset: gosubset_prok xref: GO:0015638 is_a: CCO:F0002671 ! peptide transporter activity is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0002993 name: ferrous iron uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) + energy = Fe2+(in)." [TC:9.A.8.1.1] subset: gosubset_prok xref: GO:0015639 is_a: CCO:F0002573 ! ferrous iron transmembrane transporter activity [Term] id: CCO:F0002994 name: peptidoglycan peptide transporter activity namespace: molecular_function def: "Enables the directed movement of peptidoglycan peptides into, out of, within or between cells. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "murein peptide transporter activity" EXACT [] synonym: "muropeptide transporter activity" EXACT [] xref: GO:0015640 is_a: CCO:F0002671 ! peptide transporter activity is_a: CCO:F0002997 ! peptidoglycan transporter activity [Term] id: CCO:F0002995 name: toxin binding namespace: molecular_function def: "Interacting selectively with a toxin, a poisonous substance that causes damage to biological systems. Toxins are differentiated from simple chemical poisons and vegetable alkaloids by their high molecular weight and antigenicity (they elicit an antibody response)." [GOC:ai, http://cancerweb.ncl.ac.uk/] synonym: "antitoxin activity" RELATED [] synonym: "lipoprotein antitoxin" RELATED [] xref: GO:0015643 is_a: CCO:F0000342 ! antigen binding [Term] id: CCO:F0002996 name: fatty-acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of a long-chain carboxylic acid to an acceptor, coupled to the hydrolysis of ATP." [EC:6.2.1.20, EC:6.2.1.3, GOC:mah] subset: gosubset_prok synonym: "acid:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.3] synonym: "acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "acyl-coenzyme A ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acid CoA ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] xref: EC:6.2.1.- xref: GO:0015645 is_a: CCO:F0003436 ! ligase activity, forming carbon-sulfur bonds [Term] id: CCO:F0002997 name: peptidoglycan transporter activity namespace: molecular_function def: "Enables the directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of, within or between cells." [GOC:ai] subset: gosubset_prok synonym: "murein transporter activity" EXACT [] xref: GO:0015647 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0002998 name: lipid-linked peptidoglycan transporter activity namespace: molecular_function synonym: "lipid-linked murein transporter activity" EXACT [] xref: GO:0015648 is_a: CCO:F0002997 ! peptidoglycan transporter activity [Term] id: CCO:F0002999 name: 2-keto-3-deoxygluconate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)." [TC:2.A.10.1.1] subset: gosubset_prok synonym: "2-keto-3-deoxygluconate:proton symporter" EXACT [] xref: GO:0015649 is_a: CCO:F0001605 ! cation:sugar symporter activity is_a: CCO:F0002605 ! gluconate transmembrane transporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0003000 name: lactate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)." [TC:2.A.14.1.1] synonym: "lactate permease" BROAD [] synonym: "lactate:hydrogen porter activity" EXACT [] synonym: "lactate:proton porter" EXACT [] xref: GO:0015650 is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0003001 name: quaternary ammonium group transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "quaternary amine transmembrane transporter activity" EXACT [] synonym: "quaternary ammonium compound transporter activity" EXACT [] xref: GO:0015202 xref: GO:0015651 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0002580 ! organic cation transmembrane transporter activity is_a: CCO:F0004309 ! inorganic cation transmembrane transporter activity [Term] id: CCO:F0003002 name: quaternary ammonium group:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)." [GOC:ai] subset: gosubset_prok synonym: "quaternary ammonium group:proton symporter" EXACT [] xref: GO:0015652 is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0003001 ! quaternary ammonium group transmembrane transporter activity [Term] id: CCO:F0003003 name: glycine betaine:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1] subset: gosubset_prok synonym: "glycine betaine:proton symporter" EXACT [] xref: GO:0015653 is_a: CCO:F0003002 ! quaternary ammonium group:hydrogen symporter activity [Term] id: CCO:F0003004 name: tellurite uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tellurite from the outside of a cell to the inside across a membrane: tellurite(out) + H+(out) = tellurite(in) + H+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.16.1.1] synonym: "tellurite-resistance uptake permease activity" EXACT [] synonym: "tellurite-resistance uptake transmembrane transporter activity" EXACT [] xref: GO:0015654 is_a: CCO:F0002943 ! uptake transmembrane transporter activity [Term] id: CCO:F0003005 name: alanine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)." [GOC:ai] subset: gosubset_prok xref: GO:0015655 is_a: CCO:F0001534 ! sodium:amino acid symporter activity is_a: CCO:F0001541 ! neutral L-amino acid secondary active transmembrane transporter activity [Term] id: CCO:F0003006 name: branched-chain amino acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1] xref: GO:0015657 is_a: CCO:F0001534 ! sodium:amino acid symporter activity is_a: CCO:F0003007 ! branched-chain aliphatic amino acid transmembrane transporter activity [Term] id: CCO:F0003007 name: branched-chain aliphatic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of branched-chain aliphatic amino acids from one side of a membrane to the other. Branched-chain aliphatic amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "branched-chain aliphatic amino acid transporter activity" BROAD [] synonym: "leucine/valine/isoleucine permease activity" RELATED [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] xref: GO:0015658 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0003008 name: formate uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of formate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "formate uptake permease activity" EXACT [] xref: GO:0015659 is_a: CCO:F0002894 ! formate transmembrane transporter activity is_a: CCO:F0002943 ! uptake transmembrane transporter activity [Term] id: CCO:F0003009 name: formate efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of formate from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "formate efflux permease activity" EXACT [] xref: GO:0015509 xref: GO:0015660 is_a: CCO:F0002894 ! formate transmembrane transporter activity is_a: CCO:F0002942 ! efflux transmembrane transporter activity [Term] id: CCO:F0003010 name: L-lysine efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-lysine exporter activity" EXACT [] synonym: "L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity" EXACT [] xref: GO:0015661 is_a: CCO:F0002663 ! L-lysine transmembrane transporter activity is_a: CCO:F0002942 ! efflux transmembrane transporter activity [Term] id: CCO:F0003011 name: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "P-type ATPase activity" EXACT [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] xref: GO:0015662 is_a: CCO:F0005698 ! ATPase activity, coupled to transmembrane movement of ions [Term] id: CCO:F0003012 name: nicotinamide mononucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of nicotinamide mononucleotide into, out of, within or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "nicotinamide mononucleotide permease activity" RELATED [] synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT [] xref: GO:0015663 xref: GO:0015664 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0003013 name: alcohol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0015665 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0003014 name: restriction endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mlg] subset: gosubset_prok synonym: "restriction endonuclease activity" EXACT [] synonym: "restriction enzyme activity" EXACT [] xref: GO:0015666 is_a: CCO:F0000917 ! endodeoxyribonuclease activity [Term] id: CCO:F0003015 name: site-specific DNA-methyltransferase (cytosine-N4-specific) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine." [EC:2.1.1.113] subset: gosubset_prok synonym: "DNA[cytosine-N4]methyltransferase activity" EXACT [EC:2.1.1.113] synonym: "m4C-forming MTase activity" EXACT [EC:2.1.1.113] synonym: "modification methylase activity" RELATED [EC:2.1.1.113] synonym: "N(4)-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] synonym: "N4-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.113] synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" EXACT [EC:2.1.1.113] synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" EXACT [EC:2.1.1.113] xref: EC:2.1.1.113 xref: GO:0015667 xref: MetaCyc:2.1.1.113-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity is_a: CCO:F0002339 ! DNA-methyltransferase activity [Term] id: CCO:F0003016 name: Type III site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites." [EC:3.1.21.5, PMID:12654995] subset: gosubset_prok synonym: "Type III restriction enzyme activity" EXACT [] xref: EC:3.1.21.5 xref: GO:0015668 xref: MetaCyc:3.1.21.5-RXN is_a: CCO:F0003014 ! restriction endodeoxyribonuclease activity is_a: CCO:F0003446 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0003017 name: aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.1, EC:1.4.3.16] subset: gosubset_prok xref: EC:1.4.3.- xref: GO:0015922 is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0003018 name: mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- xref: GO:0015923 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003019 name: mannosyl-oligosaccharide mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." [EC:3.2.1.-, GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- xref: GO:0015924 is_a: CCO:F0003018 ! mannosidase activity [Term] id: CCO:F0003020 name: galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- xref: GO:0015925 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003021 name: glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.2.1.- xref: GO:0015926 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003022 name: trehalase activity namespace: molecular_function def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- xref: GO:0015927 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003023 name: fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- xref: GO:0015928 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003024 name: hexosaminidase activity namespace: molecular_function def: "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [http://www.onelook.com/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok xref: EC:3.2.1.- xref: GO:0015929 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003025 name: glutamate synthase activity namespace: molecular_function def: "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-] subset: gosubset_prok xref: EC:1.4.-.- xref: GO:0015930 is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0003026 name: nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok xref: GO:0015932 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0003027 name: sulfite reductase activity namespace: molecular_function def: "Catalysis of the reaction: H2S + acceptor + 3 H2O = SO3(2-) (sulfite) + reduced acceptor." [EC:1.8.99.1] subset: gosubset_prok synonym: "assimilatory sulfite reductase activity" EXACT [EC:1.8.99.1] synonym: "assimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.1] synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.1] synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [EC:1.8.99.1] synonym: "sulphite reductase activity" EXACT [] xref: EC:1.8.99.1 xref: GO:0016002 xref: MetaCyc:SULFITE-REDUCTASE-RXN is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0003028 name: phospholipase activator activity namespace: molecular_function def: "Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai] xref: GO:0016004 is_a: CCO:F0008245 ! lipase activator activity [Term] id: CCO:F0003029 name: phospholipase A2 activator activity namespace: molecular_function def: "Increases the activity of the enzyme phospholipase A2." [GOC:ai] xref: GO:0016005 is_a: CCO:F0003028 ! phospholipase activator activity [Term] id: CCO:F0003030 name: morphogen activity namespace: molecular_function xref: GO:0016015 is_a: CCO:F0001225 ! signal transducer activity [Term] id: CCO:F0003031 name: cyclosporin A binding namespace: molecular_function def: "Interacting selectively with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb] synonym: "cyclophilin" RELATED [] xref: GO:0016018 is_a: CCO:F0001746 ! drug binding is_a: CCO:F0005639 ! peptide binding [Term] id: CCO:F0003032 name: peptidoglycan receptor activity namespace: molecular_function def: "Combining with a peptidoglycan to initiate a change in cell activity." [PMID:14698226] comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead. synonym: "peptidoglycan recognition activity" NARROW [] xref: GO:0016019 is_a: CCO:F0001838 ! pattern recognition receptor activity is_a: CCO:F0005721 ! peptidoglycan binding [Term] id: CCO:F0003033 name: metarhodopsin binding namespace: molecular_function def: "Interacting selectively with metarhodopsin, a transient intermediate produced upon irradiation of rhodopsin in the visual cycle and existing in two forms, metarhodopsins I and II. The latter dissociates to form opsin and all-trans retinal." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: GO:0016030 is_a: CCO:F0000258 ! opsin binding [Term] id: CCO:F0003034 name: maleylacetoacetate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2] subset: gosubset_prok synonym: "4-maleylacetoacetate cis-trans-isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetoacetic isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetone cis-trans-isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetone isomerase activity" EXACT [EC:5.2.1.2] xref: EC:5.2.1.2 xref: GO:0016034 xref: GO:0018841 xref: MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN xref: Reactome:23371 xref: UM-BBD_enzymeID:e0082 is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0003035 name: glutamate synthase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+." [EC:1.4.1.14] subset: gosubset_prok synonym: "glutamate (reduced nicotinamide adenine dinucleotide) synthase" EXACT [EC:1.4.1.14] synonym: "L-glutamate synthase (NADH)" EXACT [EC:1.4.1.14] synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.14] synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.14] synonym: "L-glutamate:NAD+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.14] synonym: "NADH-dependent glutamate synthase activity" EXACT [EC:1.4.1.14] synonym: "NADH-glutamate synthase activity" EXACT [EC:1.4.1.14] synonym: "NADH: GOGAT" RELATED [EC:1.4.1.14] xref: EC:1.4.1.14 xref: GO:0016040 xref: MetaCyc:GLUTAMATE-SYNTHASE-(NADH)-RXN is_a: CCO:F0006093 ! glutamate synthase activity, NADH or NADPH as acceptor [Term] id: CCO:F0003036 name: glutamate synthase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin." [EC:1.4.7.1] subset: gosubset_prok synonym: "ferredoxin-dependent glutamate synthase activity" EXACT [EC:1.4.7.1] synonym: "ferredoxin-glutamate synthase activity" EXACT [EC:1.4.7.1] synonym: "glutamate synthase (ferredoxin-dependent)" EXACT [EC:1.4.7.1] synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" EXACT [EC:1.4.7.1] xref: EC:1.4.7.1 xref: GO:0016041 xref: MetaCyc:GLUTAMATE-SYNTHASE-(FERREDOXIN)-RXN xref: MetaCyc:PWY-4341 is_a: CCO:F0003025 ! glutamate synthase activity is_a: CCO:F0003243 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0003037 name: myostimulatory hormone activity namespace: molecular_function xref: GO:0016084 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0003038 name: myoinhibitory hormone activity namespace: molecular_function xref: GO:0016085 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0003039 name: ecdysiostatic hormone activity namespace: molecular_function xref: GO:0016087 is_a: CCO:F0001481 ! neuropeptide hormone activity [Term] id: CCO:F0003040 name: translation release factor activity, codon specific namespace: molecular_function def: "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684] subset: gosubset_prok xref: GO:0016149 is_a: CCO:F0000318 ! translation release factor activity [Term] id: CCO:F0003041 name: translation release factor activity, codon nonspecific namespace: molecular_function def: "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684] comment: Consider also annotating to the molecular function term 'GTP binding ; GO:0005525'. xref: GO:0016150 is_a: CCO:F0000318 ! translation release factor activity [Term] id: CCO:F0003042 name: nickel ion binding namespace: molecular_function def: "Interacting selectively with nickel (Ni) ions." [GOC:ai] subset: gosubset_prok synonym: "nickel binding" EXACT [] xref: GO:0016151 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0003043 name: mercury (II) reductase activity namespace: molecular_function def: "Catalysis of the reaction: Hg + NADP+ + H+ = Hg2+ + NADPH + H+." [EC:1.16.1.1] subset: gosubset_prok synonym: "Hg:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.1] synonym: "mer A" RELATED [EC:1.16.1.1] synonym: "mercurate(II) reductase activity" EXACT [EC:1.16.1.1] synonym: "mercuric ion reductase activity" EXACT [EC:1.16.1.1] synonym: "mercuric reductase activity" EXACT [EC:1.16.1.1] synonym: "mercury reductase activity" EXACT [EC:1.16.1.1] synonym: "mercury(II) reductase activity" EXACT [EC:1.16.1.1] synonym: "reduced NADP:mercuric ion oxidoreductase activity" EXACT [EC:1.16.1.1] xref: EC:1.16.1.1 xref: GO:0016152 xref: GO:0018692 xref: MetaCyc:MERCURY-(II)-REDUCTASE-RXN xref: UM-BBD_enzymeID:e0056 is_a: CCO:F0003305 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: CCO:F0003044 name: urocanate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydro-4-oxo-5-imidazolepropanoate = urocanate + H2O." [EC:4.2.1.49] subset: gosubset_prok synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)" EXACT [EC:4.2.1.49] synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity" EXACT [EC:4.2.1.49] synonym: "imidazolonepropionate hydrolase activity" EXACT [EC:4.2.1.49] synonym: "urocanase activity" EXACT [EC:4.2.1.49] xref: EC:4.2.1.49 xref: GO:0016153 xref: MetaCyc:UROCANATE-HYDRATASE-RXN xref: Reactome:23891 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003045 name: pyrimidine-nucleoside phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2] subset: gosubset_prok synonym: "Py-NPase activity" EXACT [EC:2.4.2.2] synonym: "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.2] xref: EC:2.4.2.2 xref: GO:0016154 xref: MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0003046 name: formyltetrahydrofolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+." [EC:1.5.1.6] synonym: "10-formyl tetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "10-formyl-H2PtGlu:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "10-formyl-H4folate dehydrogenase activity" EXACT [EC:1.5.1.6] synonym: "10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] synonym: "10-formyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "N10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] xref: EC:1.5.1.6 xref: GO:0016155 xref: MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003047 name: fumarate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: succinate + NAD+ = fumarate + NADH + H+." [EC:1.3.1.6] subset: gosubset_prok synonym: "NADH-dependent fumarate reductase activity" EXACT [EC:1.3.1.6] synonym: "NADH-fumarate reductase activity" EXACT [EC:1.3.1.6] synonym: "succinate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.6] xref: EC:1.3.1.6 xref: GO:0016156 xref: MetaCyc:FUMARATE-REDUCTASE-(NADH)-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003048 name: sucrose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." [EC:2.4.1.13] subset: gosubset_prok synonym: "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "sucrose synthetase activity" EXACT [EC:2.4.1.13] synonym: "sucrose-UDP glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "sucrose-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "UDP-glucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "UDPglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "uridine diphosphoglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] xref: EC:2.4.1.13 xref: GO:0016157 xref: MetaCyc:SUCROSE-SYNTHASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0003049 name: 3-phytase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8] subset: gosubset_prok synonym: "1-phytase activity" EXACT [EC:3.1.3.8] synonym: "myo-inositol-hexakisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.8] synonym: "myo-inositol-hexaphosphate 3-phosphohydrolase activity" EXACT [] synonym: "phytase activity" BROAD [] synonym: "phytate 1-phosphatase activity" EXACT [EC:3.1.3.8] synonym: "phytate 3-phosphatase activity" EXACT [] xref: EC:3.1.3.8 xref: GO:0016158 xref: MetaCyc:RXN0-1001 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0003050 name: muconolactone delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate." [EC:5.3.3.4] subset: gosubset_prok synonym: "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.4] synonym: "muconolactone D-isomerase activity" EXACT [] synonym: "muconolactone isomerase activity" EXACT [EC:5.3.3.4] xref: EC:5.3.3.4 xref: GO:0016159 xref: MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0003051 name: amylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of amylose or an amylose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- xref: GO:0016160 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003052 name: beta-amylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [EC:3.2.1.2] subset: gosubset_prok synonym: "1,4-alpha-D-glucan maltohydrolase activity" EXACT [EC:3.2.1.2] synonym: "beta amylase activity" EXACT [EC:3.2.1.2] synonym: "glycogenase activity" BROAD [EC:3.2.1.2] synonym: "saccharogen amylase activity" EXACT [EC:3.2.1.2] xref: EC:3.2.1.2 xref: GO:0016161 xref: MetaCyc:3.2.1.2-RXN is_a: CCO:F0003051 ! amylase activity [Term] id: CCO:F0003053 name: cellulose 1,4-beta-cellobiosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] subset: gosubset_prok synonym: "1,4-beta-cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "1,4-beta-D-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "1,4-beta-glucan cellobiosidase activity" EXACT [EC:3.2.1.91] synonym: "avicelase activity" BROAD [EC:3.2.1.91] synonym: "beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "beta-1,4-glucan cellobiosylhydrolase activity" EXACT [EC:3.2.1.91] synonym: "C1 cellulase activity" EXACT [EC:3.2.1.91] synonym: "CBH 1" RELATED [EC:3.2.1.91] synonym: "cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "cellobiohydrolase I" RELATED [EC:3.2.1.91] synonym: "cellobiosidase activity" EXACT [EC:3.2.1.91] synonym: "exo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.91] synonym: "exo-beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exo-cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exocellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exoglucanase activity" EXACT [EC:3.2.1.91] xref: EC:3.2.1.91 xref: GO:0016162 xref: MetaCyc:3.2.1.91-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003054 name: nitrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] subset: gosubset_prok synonym: "iron-iron nitrogenase activity" NARROW [] synonym: "molybdenum-iron nitrogenase activity" NARROW [] synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity" EXACT [EC:1.18.6.1] synonym: "vanadium-iron nitrogenase activity" NARROW [] xref: EC:1.18.6.1 xref: GO:0016163 xref: MetaCyc:NITROGENASE-RXN xref: UM-BBD_enzymeID:e0395 is_a: CCO:F0003313 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor [Term] id: CCO:F0003055 name: Mo-molybdopterin oxidoreductase activity namespace: molecular_function subset: gosubset_prok synonym: "molybdopterin oxidoreductase activity" EXACT [] xref: GO:0016164 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003056 name: lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12] subset: gosubset_prok synonym: "carotene oxidase activity" NARROW [EC:1.13.11.12] synonym: "fat oxidase activity" EXACT [EC:1.13.11.12] synonym: "linoleate:oxygen 13-oxidoreductase activity" EXACT [EC:1.13.11.12] synonym: "lionoleate:O2 oxidoreductase activity" EXACT [EC:1.13.11.12] synonym: "lipoperoxidase activity" EXACT [EC:1.13.11.12] synonym: "lipoxidase activity" EXACT [EC:1.13.11.12] synonym: "lipoxydase activity" EXACT [EC:1.13.11.12] xref: EC:1.13.11.12 xref: GO:0016165 xref: MetaCyc:LIPOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003057 name: phytoene dehydrogenase activity namespace: molecular_function def: "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/terp/carot.html] subset: gosubset_prok xref: EC:1.3.-.- xref: GO:0016166 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003058 name: glial cell line-derived neurotrophic factor receptor activity namespace: molecular_function xref: GO:0016167 is_a: CCO:F0001244 ! hematopoietin/interferon-class (D200-domain) cytokine receptor activity [Term] id: CCO:F0003059 name: chlorophyll binding namespace: molecular_function def: "Interacting selectively with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] subset: gosubset_prok xref: GO:0016168 is_a: CCO:F0006264 ! tetrapyrrole binding [Term] id: CCO:F0003060 name: bacteriochlorophyll c binding namespace: molecular_function def: "Interacting selectively with bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981] subset: gosubset_prok xref: GO:0016169 is_a: CCO:F0005658 ! bacteriochlorophyll binding [Term] id: CCO:F0003061 name: interleukin-15 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-15 receptor." [GOC:ai] synonym: "IL-15" NARROW [] synonym: "interleukin-15 receptor ligand" NARROW [] xref: GO:0016170 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0003062 name: NAD(P)H oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + H2O2." [EC:1.6.3.1] synonym: "dual oxidase activity" RELATED [EC:1.6.3.1] synonym: "NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.6.3.1] synonym: "NADPH oxidase" BROAD [EC:1.6.3.1] synonym: "p138tox" RELATED [EC:1.6.3.1] synonym: "ThOX activity" NARROW [EC:1.6.3.1] synonym: "THOX2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid NADPH oxidase activity" NARROW [] synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1] xref: EC:1.6.3.1 xref: GO:0016174 is_a: CCO:F0007989 ! oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor [Term] id: CCO:F0003063 name: superoxide-generating NADPH oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195] synonym: "cytochrome B-245" RELATED [] xref: EC:1.6.3.- xref: GO:0016175 is_a: CCO:F0007989 ! oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor [Term] id: CCO:F0003064 name: superoxide-generating NADPH oxidase activator activity namespace: molecular_function def: "Increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai] synonym: "neutrophil cytosol factor 2" NARROW [] xref: GO:0016176 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0003065 name: selenocysteine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.-, PMID:10026151] xref: EC:2.1.1.- xref: GO:0016205 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0003066 name: catechol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol." [EC:2.1.1.6] subset: gosubset_prok synonym: "catechol methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "catecholamine O-methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "COMT I" RELATED [EC:2.1.1.6] synonym: "COMT II" RELATED [EC:2.1.1.6] synonym: "MB-COMT (membrane-bound form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] synonym: "S-adenosyl-L-methionine:catechol O-methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] xref: EC:2.1.1.6 xref: GO:0016206 xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN xref: Reactome:24294 is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003067 name: 4-coumarate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12] subset: gosubset_prok synonym: "4-coumarate-CoA synthetase activity" EXACT [] synonym: "4-coumarate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.12] synonym: "4-coumarate:CoA ligase activity" EXACT [] synonym: "4-coumarate:coenzyme A ligase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaroyl-CoA synthase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaroyl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "4CL" RELATED [EC:6.2.1.12] synonym: "caffeolyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "feruloyl CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "feruloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "hydroxycinnamate:CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "hydroxycinnamoyl CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaroyl CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl-CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-hydroxycinnamic acid:CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-hydroxycinnamoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "sinapoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] xref: EC:6.2.1.12 xref: GO:0016207 xref: MetaCyc:4-COUMARATE--COA-LIGASE-RXN is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0003068 name: AMP binding namespace: molecular_function def: "Interacting selectively with AMP, adenosine monophosphate." [GOC:go_curators] subset: gosubset_prok xref: GO:0016208 is_a: CCO:F0005022 ! adenyl ribonucleotide binding [Term] id: CCO:F0003069 name: antioxidant activity namespace: molecular_function def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: gosubset_prok xref: GO:0016209 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0003070 name: naringenin-chalcone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74] subset: gosubset_prok synonym: "chalcone synthase activity" EXACT [EC:2.3.1.74] synonym: "chalcone synthetase activity" EXACT [] synonym: "CHS" EXACT [] synonym: "DOCS" NARROW [] synonym: "flavanone synthase activity" EXACT [EC:2.3.1.74] synonym: "flavonone synthase activity" EXACT [EC:2.3.1.74] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.74] xref: EC:2.3.1.74 xref: GO:0016210 xref: MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0003071 name: ammonia ligase activity namespace: molecular_function def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok xref: EC:6.3.1.- xref: GO:0016211 is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0003072 name: kynurenine-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7] subset: gosubset_prok synonym: "kynurenine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine transaminase (cyclizing)" EXACT [EC:2.6.1.7] synonym: "kynurenine--oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine-oxoglutarate aminotransferase activity" EXACT [] synonym: "L-kynurenine aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "L-kynurenine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] xref: EC:2.6.1.7 xref: GO:0016212 xref: MetaCyc:2.6.1.7-RXN xref: Reactome:24302 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0003073 name: linoleoyl-CoA desaturase activity namespace: molecular_function def: "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O." [EC:1.14.19.3] comment: Note that this function was formerly EC:1.14.99.25. subset: gosubset_prok synonym: "delta(6)-acyl CoA desaturase activity" BROAD [] synonym: "delta(6)-desaturase activity" BROAD [] synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD [] synonym: "delta6-acyl CoA desaturase activity" EXACT [EC:1.14.19.3] synonym: "delta6-desaturase activity" EXACT [EC:1.14.19.3] synonym: "delta6-fatty acyl-CoA desaturase activity" EXACT [EC:1.14.19.3] synonym: "fatty acid 6-desaturase activity" BROAD [] synonym: "fatty acid delta(6)-desaturase activity" BROAD [] synonym: "fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] synonym: "linoleate desaturase activity" RELATED [] synonym: "linoleic acid desaturase activity" RELATED [] synonym: "linoleic desaturase activity" RELATED [] synonym: "linoleoyl CoA desaturase activity" EXACT [] synonym: "linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.3] synonym: "linoleoyl-coenzyme A desaturase activity" EXACT [] synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD [] synonym: "long-chain fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] xref: EC:1.14.19.3 xref: GO:0016213 xref: MetaCyc:1.14.19.3-RXN is_a: CCO:F0003300 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: CCO:F0003074 name: CoA desaturase activity namespace: molecular_function subset: gosubset_prok xref: EC:1.14.99.- xref: GO:0016215 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003075 name: isopenicillin-N synthase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine = isopenicillin-N + H2O." [EC:1.21.3.1, PMID:12926272] subset: gosubset_prok synonym: "isopenicillin N synthase activity" EXACT [EC:1.21.3.1] synonym: "isopenicillin-N synthetase activity" EXACT [] synonym: "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.1] xref: EC:1.21.3.1 xref: GO:0016216 xref: MetaCyc:1.21.3.1-RXN is_a: CCO:F0006307 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: CCO:F0003076 name: N-ethylammeline chlorohydrolase activity namespace: molecular_function xref: GO:0016217 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0003077 name: polyketide synthase activity namespace: molecular_function subset: gosubset_prok xref: GO:0016218 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0003078 name: GDP-dissociation stimulator activity namespace: molecular_function synonym: "GDS" EXACT [] xref: GO:0016219 is_a: CCO:F0001388 ! small GTPase regulator activity [Term] id: CCO:F0003079 name: RAL GDP-dissociation stimulator activity namespace: molecular_function xref: GO:0016220 is_a: CCO:F0003078 ! GDP-dissociation stimulator activity [Term] id: CCO:F0003080 name: beta-alanine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine." [EC:2.6.1.18] subset: gosubset_prok synonym: "beta-alanine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] synonym: "beta-alanine-alpha-alanine transaminase activity" EXACT [EC:2.6.1.18] synonym: "beta-alanine-pyruvate aminotransferase activity" EXACT [] synonym: "L-alanine:3-oxopropanoate aminotransferase activity" EXACT [EC:2.6.1.18] synonym: "omega-amino acid--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] xref: EC:2.6.1.18 xref: GO:0016223 xref: MetaCyc:2.6.1.18-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0003081 name: tRNA sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4] synonym: "L-cysteine:tRNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer RNA thiolase activity" EXACT [EC:2.8.1.4] synonym: "tRNA sulphurtransferase activity" EXACT [] xref: EC:2.8.1.4 xref: GO:0016227 xref: MetaCyc:TRNA-SULFURTRANSFERASE-RXN is_a: CCO:F0003355 ! sulfurtransferase activity [Term] id: CCO:F0003082 name: steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah] subset: gosubset_prok xref: EC:1.1.1.- xref: GO:0016229 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003083 name: sphingomyelin phosphodiesterase activator activity namespace: molecular_function def: "Increases the activity of the enzyme sphingomyelin phosphodiesterase." [GOC:ai] synonym: "neutral sphingomyelinase activator" EXACT [] xref: GO:0016230 is_a: CCO:F0003028 ! phospholipase activator activity [Term] id: CCO:F0003084 name: beta-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN] xref: GO:0016231 is_a: CCO:F0000947 ! beta-N-acetylhexosaminidase activity [Term] id: CCO:F0003085 name: HNK-1 sulfotransferase activity namespace: molecular_function def: "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R)." [PMID:9478973] synonym: "HNK-1 sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0016232 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0003086 name: channel regulator activity namespace: molecular_function subset: gosubset_prok xref: GO:0016247 is_a: CCO:F0002865 ! auxiliary transport protein activity [Term] id: CCO:F0003087 name: channel inhibitor activity namespace: molecular_function subset: gosubset_prok xref: GO:0016248 is_a: CCO:F0003086 ! channel regulator activity [Term] id: CCO:F0003088 name: channel localizer activity namespace: molecular_function def: "Functions to locate the position of ion channels in the cell." [PMID:10218120] xref: GO:0016249 is_a: CCO:F0002865 ! auxiliary transport protein activity [Term] id: CCO:F0003089 name: N-sulfoglucosamine sulfohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + SO4(2-) (sulfate)." [EC:3.10.1.1] synonym: "2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)" EXACT [EC:3.10.1.1] synonym: "heparin sulfamidase activity" EXACT [EC:3.10.1.1] synonym: "N-sulfo-D-glucosamine sulfohydrolase activity" EXACT [EC:3.10.1.1] synonym: "N-sulphoglucosamine sulphohydrolase activity" EXACT [] synonym: "sulfoglucosamine sulfamidase activity" EXACT [EC:3.10.1.1] synonym: "sulphamidase activity" EXACT [EC:3.10.1.1] xref: EC:3.10.1.1 xref: GO:0016250 xref: MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN is_a: CCO:F0003393 ! hydrolase activity, acting on acid sulfur-nitrogen bonds [Term] id: CCO:F0003090 name: general RNA polymerase II transcription factor activity namespace: molecular_function def: "Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF)." [PMID:10384286, PMID:9774831] xref: GO:0003703 xref: GO:0016251 is_a: CCO:F0000291 ! RNA polymerase II transcription factor activity [Term] id: CCO:F0003091 name: nonspecific RNA polymerase II transcription factor activity namespace: molecular_function def: "Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl] xref: GO:0016252 is_a: CCO:F0000291 ! RNA polymerase II transcription factor activity [Term] id: CCO:F0003092 name: UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + peptide = UDP + N-acetyl-beta-D-glucosaminyl-peptide." [UniProtKB:O15294] xref: EC:2.4.1.- xref: GO:0016253 is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0003093 name: protein N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94] synonym: "N-GlcNAc transferase activity" EXACT [EC:2.4.1.94] synonym: "O-GlcNAc transferase activity" EXACT [] synonym: "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity" EXACT [] synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT [] xref: EC:2.4.1.94 xref: GO:0016262 xref: MetaCyc:2.4.1.94-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0003094 name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma] synonym: "Core 1 GalT" RELATED [] synonym: "UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] synonym: "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] synonym: "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity" EXACT [EC:2.4.1.122] xref: EC:2.4.1.122 xref: GO:0016263 xref: MetaCyc:2.4.1.122-RXN is_a: CCO:F0007345 ! beta-1,3-galactosyltransferase activity [Term] id: CCO:F0003095 name: arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah] xref: EC:2.1.1.- xref: GO:0016273 is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003096 name: protein-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue in a protein substrate." [GOC:mah, PMID:12351636] xref: EC:2.1.1.- xref: GO:0016274 is_a: CCO:F0003095 ! arginine N-methyltransferase activity [Term] id: CCO:F0003099 name: lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0016278 is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003100 name: protein-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0016279 is_a: CCO:F0001813 ! protein methyltransferase activity is_a: CCO:F0003099 ! lysine N-methyltransferase activity [Term] id: CCO:F0003101 name: alanine aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl] subset: gosubset_prok xref: EC:3.4.11.- xref: GO:0016284 is_a: CCO:F0000646 ! aminopeptidase activity [Term] id: CCO:F0003102 name: cytosol alanyl aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14] subset: gosubset_prok synonym: "aminopolypeptidase activity" EXACT [EC:3.4.11.14] synonym: "arylamidase activity" NARROW [EC:3.4.11.14] synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14] synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14] synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14] synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14] synonym: "soluble alanyl aminopeptidase activity" EXACT [EC:3.4.11.14] synonym: "thiol-activated aminopeptidase activity" EXACT [EC:3.4.11.14] xref: EC:3.4.11.14 xref: GO:0016285 xref: MetaCyc:3.4.11.14-RXN is_a: CCO:F0001785 ! metalloexopeptidase activity is_a: CCO:F0003101 ! alanine aminopeptidase activity [Term] id: CCO:F0003103 name: small conductance calcium-activated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] synonym: "SK calcium-activated potassium channel activity " EXACT [] synonym: "SK KCa channels" EXACT [] synonym: "small conductance KCa channels " EXACT [] xref: GO:0016286 is_a: CCO:F0002726 ! calcium-activated potassium channel activity [Term] id: CCO:F0003104 name: glycerone-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate." [EC:2.3.1.42] synonym: "acyl-CoA:glycerone-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.42] synonym: "dihydroxyacetone phosphate acyltransferase activity" EXACT [EC:2.3.1.42] xref: EC:2.3.1.42 xref: GO:0016287 xref: MetaCyc:2.3.1.42-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0003105 name: CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group." [GOC:ai] subset: gosubset_prok xref: EC:3.1.2.- xref: GO:0016289 is_a: CCO:F0003361 ! thiolester hydrolase activity [Term] id: CCO:F0003106 name: palmitoyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [EC:3.1.2.2] subset: gosubset_prok synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2] synonym: "long-chain fatty-acyl-CoA hydrolase activity" EXACT [] synonym: "palmitoyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl-CoA deacylase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2] synonym: "palmityl-CoA deacylase activity" EXACT [EC:3.1.2.2] xref: EC:3.1.2.2 xref: GO:0016290 xref: GO:0016293 xref: MetaCyc:PALMITOYL-COA-HYDROLASE-RXN xref: MetaCyc:PWY-5148 is_a: CCO:F0003107 ! acyl-CoA thioesterase activity [Term] id: CCO:F0003107 name: acyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + H2O = corresponding fatty acid + CoA." [PMID:14660652] subset: gosubset_prok synonym: "acyl-CoA thioesterase I activity" NARROW [] synonym: "acyl-CoA thioesterase II activity" NARROW [] synonym: "acyl-CoA thiolesterase activity" EXACT [] xref: EC:3.1.2.- xref: GO:0008778 xref: GO:0016291 xref: GO:0016292 is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0003108 name: myristoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14] synonym: "myristoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "myristoyl-ACP hydrolase activity" EXACT [] synonym: "tetradecanoyl-[acyl-carrier-protein] hydrolase activity" EXACT [] synonym: "tetradecanoyl-ACP hydrolase activity" EXACT [] xref: GO:0016295 is_a: CCO:F0003110 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: CCO:F0003109 name: palmitoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14] synonym: "palmitoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "palmitoyl-ACP hydrolase activity" EXACT [] xref: GO:0016296 is_a: CCO:F0003110 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: CCO:F0003110 name: acyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + organic acid." [EC:3.1.2.14] subset: gosubset_prok synonym: "acyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "acyl-ACP hydrolase activity" EXACT [] synonym: "acyl-ACP thioesterase activity" EXACT [] synonym: "acyl-ACP-hydrolase activity" EXACT [EC:3.1.2.14] synonym: "acyl-acyl carrier protein hydrolase activity" EXACT [EC:3.1.2.14] synonym: "acyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.14] synonym: "S-acyl fatty acid synthase thioesterase activity" EXACT [EC:3.1.2.14] xref: GO:0010281 xref: GO:0016297 is_a: CCO:F0000733 ! fatty-acid synthase activity is_a: CCO:F0003361 ! thiolester hydrolase activity [Term] id: CCO:F0003111 name: lipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] subset: gosubset_prok xref: EC:3.1.1.- xref: GO:0016298 xref: Reactome:1913 is_a: CCO:F0003360 ! hydrolase activity, acting on ester bonds [Term] id: CCO:F0003112 name: regulator of G-protein signaling activity namespace: molecular_function def: "Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [UniProtKB:O08774] synonym: "regulator of G protein signaling activity" EXACT [] synonym: "regulator of G protein signalling activity" EXACT [] synonym: "regulator of G-protein signalling activity" EXACT [] synonym: "RGS" EXACT [] xref: GO:0016299 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0003113 name: tRNA (uracil) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). subset: gosubset_prok synonym: "tRNA (uridine) methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: GO:0016300 xref: GO:0016431 is_a: CCO:F0001762 ! tRNA methyltransferase activity [Term] id: CCO:F0003114 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: gosubset_prok synonym: "phosphokinase activity" EXACT [] xref: GO:0016301 xref: Reactome:1423 is_a: CCO:F0003344 ! transferase activity, transferring phosphorus-containing groups [Term] id: CCO:F0003115 name: 1-phosphatidylinositol-3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137, PMID:9759495] synonym: "1-phosphatidylinositol 3-kinase activity" EXACT [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity" EXACT [EC:2.7.1.137] synonym: "phosphatidylinositol 3-kinase activity" EXACT [] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class III" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "PI3-kinase activity" EXACT [EC:2.7.1.137] synonym: "PI3K" EXACT [] synonym: "PtdIns-3-kinase activity" EXACT [EC:2.7.1.137] synonym: "type I phosphatidylinositol kinase activity" NARROW [EC:2.7.1.137] synonym: "type III phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.137] synonym: "Vps34p" RELATED [EC:2.7.1.137] xref: EC:2.7.1.137 xref: GO:0004429 xref: GO:0016303 xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN is_a: CCO:F0005553 ! phosphoinositide 3-kinase activity [Term] id: CCO:F0003116 name: phosphatidylinositol phosphate kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495] subset: gosubset_prok xref: EC:2.7.1.- xref: GO:0016307 is_a: CCO:F0000204 ! lipid kinase activity is_a: CCO:F0000836 ! inositol or phosphatidylinositol kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0003117 name: 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.68] subset: gosubset_prok synonym: "1-phosphatidylinositol-4-phosphate kinase activity" BROAD [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.68] synonym: "diphosphoinositide kinase activity" BROAD [EC:2.7.1.68] synonym: "phosphatidylinositol 4-phosphate kinase activity" BROAD [EC:2.7.1.68] synonym: "phosphatidylinositol-4-phosphate 5-kinase activity" EXACT [EC:2.7.1.68] synonym: "PIP kinase activity" BROAD [EC:2.7.1.68] synonym: "PIP5K" EXACT [] synonym: "PtdIns(4)P-5-kinase activity" EXACT [EC:2.7.1.68] synonym: "type I PIP kinase activity" NARROW [EC:2.7.1.68] xref: EC:2.7.1.68 xref: GO:0004431 xref: GO:0016308 xref: GO:0045215 xref: MetaCyc:2.7.1.68-RXN is_a: CCO:F0003116 ! phosphatidylinositol phosphate kinase activity [Term] id: CCO:F0003118 name: 1-phosphatidylinositol-5-phosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149] synonym: "1-phosphatidylinositol-5-phosphate kinase" BROAD [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" EXACT [EC:2.7.1.149] synonym: "PIP4K" EXACT [] synonym: "type II PIP kinase activity" NARROW [EC:2.7.1.149] xref: EC:2.7.1.149 xref: GO:0016309 xref: MetaCyc:2.7.1.149-RXN is_a: CCO:F0003116 ! phosphatidylinositol phosphate kinase activity [Term] id: CCO:F0003119 name: inositol bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the removal of one of the two phosphate groups of an inositol bisphosphate." [GOC:hb] xref: EC:3.1.3.- xref: GO:0016312 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity [Term] id: CCO:F0003120 name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidyl inositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67] synonym: "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] synonym: "MMAC1" RELATED [EC:3.1.3.67] synonym: "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] xref: EC:3.1.3.67 xref: GO:0016314 xref: MetaCyc:3.1.3.67-RXN xref: Reactome:24758 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity is_a: CCO:F0005684 ! lipid phosphatase activity [Term] id: CCO:F0003121 name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb] synonym: "1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66] synonym: "D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66] synonym: "inositol polyphosphate 4-phosphatase activity" BROAD [EC:3.1.3.66] synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] synonym: "inositol-1,4,-bisphosphate 4-phosphatase activity" EXACT [] synonym: "inositol-3,4-bisphosphate 4-phosphatase activity" EXACT [] synonym: "phosphoinositide 4-phosphatase activity" BROAD [EC:3.1.3.66] xref: EC:3.1.3.66 xref: GO:0004440 xref: GO:0016316 xref: MetaCyc:3.1.3.66-RXN is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity is_a: CCO:F0005684 ! lipid phosphatase activity [Term] id: CCO:F0003122 name: activin receptor activity, type I namespace: molecular_function def: "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651] synonym: "type I activin receptor activity" EXACT [] xref: GO:0016361 is_a: CCO:F0001355 ! transforming growth factor beta receptor activity, type I is_a: CCO:F0003510 ! activin receptor activity [Term] id: CCO:F0003123 name: activin receptor activity, type II namespace: molecular_function def: "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to catalyzes the phosphorylation of type I activin receptor." [GOC:mah, PMID:8622651] synonym: "type II activin receptor activity" EXACT [] xref: GO:0016362 is_a: CCO:F0001356 ! transforming growth factor beta receptor activity, type II is_a: CCO:F0003510 ! activin receptor activity [Term] id: CCO:F0003124 name: palmitoyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + H2O2." [GOC:jsg] xref: EC:1.3.3.- xref: GO:0016401 is_a: CCO:F0000482 ! acyl-CoA oxidase activity [Term] id: CCO:F0003125 name: pristanoyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + H2O2." [GOC:jsg] xref: EC:1.3.3.- xref: GO:0016402 is_a: CCO:F0000482 ! acyl-CoA oxidase activity [Term] id: CCO:F0003126 name: dimethylargininase activity namespace: molecular_function def: "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18] subset: gosubset_prok synonym: "dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] synonym: "N(G),N(G)-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] synonym: "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity" EXACT [EC:3.5.3.18] synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] xref: EC:3.5.3.18 xref: GO:0016403 xref: MetaCyc:DIMETHYLARGININASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0003127 name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141] synonym: "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] synonym: "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] synonym: "15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "15-hydroxyprostanoic dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "15-OH-PGDH" RELATED [EC:1.1.1.141] synonym: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)" EXACT [EC:1.1.1.141] synonym: "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "prostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] xref: EC:1.1.1.141 xref: GO:0016404 xref: MetaCyc:1.1.1.141-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003128 name: CoA-ligase activity namespace: molecular_function def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai] subset: gosubset_prok xref: GO:0016405 xref: Reactome:10971 is_a: CCO:F0003436 ! ligase activity, forming carbon-sulfur bonds [Term] id: CCO:F0003129 name: carnitine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016406 is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0003130 name: acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai] subset: gosubset_prok synonym: "acetylase activity" EXACT [] xref: EC:2.3.1.- xref: GO:0016407 xref: Reactome:1621 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003131 name: C-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016408 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003132 name: palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0016409 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003133 name: N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016410 xref: Reactome:1095 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003134 name: acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016411 is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0003135 name: serine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016412 is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0003136 name: O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016413 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0003130 ! acetyltransferase activity [Term] id: CCO:F0003137 name: O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0016414 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0003138 ! octanoyltransferase activity [Term] id: CCO:F0003138 name: octanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0016415 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003139 name: O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0016416 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0003132 ! palmitoyltransferase activity [Term] id: CCO:F0003140 name: S-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016417 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003141 name: S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016418 is_a: CCO:F0003130 ! acetyltransferase activity is_a: CCO:F0003140 ! S-acyltransferase activity [Term] id: CCO:F0003142 name: S-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an malonyl group to a sulfur atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016419 is_a: CCO:F0003140 ! S-acyltransferase activity is_a: CCO:F0003143 ! malonyltransferase activity [Term] id: CCO:F0003143 name: malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an malonyl (HOOC-CH2-CO-) group to an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016420 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003144 name: CoA carboxylase activity namespace: molecular_function subset: gosubset_prok xref: EC:6.4.1.- xref: GO:0016421 is_a: CCO:F0003443 ! ligase activity, forming carbon-carbon bonds [Term] id: CCO:F0003145 name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62] synonym: "messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity" EXACT [EC:2.1.1.62] synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.62] synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.62] xref: EC:2.1.1.62 xref: GO:0016422 xref: MetaCyc:2.1.1.62-RXN is_a: CCO:F0001761 ! mRNA methyltransferase activity [Term] id: CCO:F0003146 name: tRNA (guanine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in a tRNA molecule." [GOC:mah] subset: gosubset_prok synonym: "tRNA (guanosine) methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: GO:0016423 xref: GO:0016424 is_a: CCO:F0001762 ! tRNA methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003148 name: tRNA (adenine)-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in a tRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0016426 is_a: CCO:F0001762 ! tRNA methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003149 name: tRNA (cytosine)-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in a tRNA molecule." [GOC:mah] xref: EC:2.1.1.- xref: GO:0016427 is_a: CCO:F0001762 ! tRNA methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003150 name: tRNA (cytosine-5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29] synonym: "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.29] synonym: "transfer ribonucleate cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] synonym: "transfer RNA cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] xref: EC:2.1.1.29 xref: GO:0016428 xref: MetaCyc:TRNA-(CYTOSINE-5-)-METHYLTRANSFERASE-RXN is_a: CCO:F0003149 ! tRNA (cytosine)-methyltransferase activity [Term] id: CCO:F0003151 name: tRNA (adenine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36] subset: gosubset_prok synonym: "1-methyladenine transfer RNA methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "adenine-1-methylase activity" EXACT [EC:2.1.1.36] synonym: "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "transfer ribonucleate adenine 1-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "transfer RNA (adenine-1) methyltransferase activity" EXACT [EC:2.1.1.36] xref: EC:2.1.1.36 xref: GO:0016429 xref: MetaCyc:TRNA-(ADENINE-N1-)-METHYLTRANSFERASE-RXN is_a: CCO:F0003148 ! tRNA (adenine)-methyltransferase activity [Term] id: CCO:F0003152 name: tRNA (adenine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55] synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.55] synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.55] xref: EC:2.1.1.55 xref: GO:0016430 xref: MetaCyc:TRNA-(ADENINE-N6-)-METHYLTRANSFERASE-RXN is_a: CCO:F0003148 ! tRNA (adenine)-methyltransferase activity [Term] id: CCO:F0003154 name: tRNA-uridine aminocarboxypropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25] synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.25] xref: EC:2.5.1.25 xref: GO:0016432 xref: MetaCyc:2.5.1.25-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0003155 name: rRNA (adenine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0016433 is_a: CCO:F0002014 ! rRNA methyltransferase activity [Term] id: CCO:F0003156 name: rRNA (cytosine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0016434 is_a: CCO:F0002014 ! rRNA methyltransferase activity [Term] id: CCO:F0003157 name: rRNA (guanine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0016435 is_a: CCO:F0002014 ! rRNA methyltransferase activity [Term] id: CCO:F0003158 name: rRNA (uridine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a uridine residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0016436 is_a: CCO:F0002014 ! rRNA methyltransferase activity [Term] id: CCO:F0003159 name: tRNA cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.21] synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.21] synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" EXACT [EC:2.7.7.21] synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "CTP:tRNA cytidylyltransferase activity" EXACT [] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.21] synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.21] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.21] synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.21] xref: EC:2.7.7.21 xref: GO:0016437 xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0003160 name: tRNA-queuosine beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine." [EC:2.4.1.110] synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.110] xref: EC:2.4.1.110 xref: GO:0016438 xref: MetaCyc:2.4.1.110-RXN is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0003161 name: tRNA-pseudouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12] comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. subset: gosubset_prok synonym: "transfer ribonucleate pseudouridine synthetase activity" EXACT [EC:5.4.99.12] synonym: "transfer RNA pseudouridine synthetase activity" EXACT [EC:5.4.99.12] synonym: "tRNA pseudouridylate synthase I activity" NARROW [EC:5.4.99.12] synonym: "tRNA-pseudouridine synthase I activity" NARROW [] synonym: "tRNA-uridine isomerase activity" EXACT [EC:5.4.99.12] synonym: "tRNA-uridine uracilmutase activity" EXACT [EC:5.4.99.12] xref: EC:5.4.99.12 xref: GO:0016439 xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN is_a: CCO:F0002433 ! pseudouridine synthase activity [Term] id: CCO:F0003162 name: bidentate ribonuclease III activity namespace: molecular_function def: "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644] synonym: "bidentate RNase III activity" EXACT [] xref: EC:3.1.26.- xref: GO:0016443 is_a: CCO:F0000921 ! ribonuclease III activity [Term] id: CCO:F0003163 name: C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: GO:0016453 is_a: CCO:F0003130 ! acetyltransferase activity is_a: CCO:F0003131 ! C-acyltransferase activity [Term] id: CCO:F0003164 name: C-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0016454 is_a: CCO:F0003131 ! C-acyltransferase activity is_a: CCO:F0003132 ! palmitoyltransferase activity [Term] id: CCO:F0003165 name: RNA polymerase II transcription mediator activity namespace: molecular_function def: "Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex." [GOC:ma] synonym: "thyroid receptor-associated protein" RELATED [] synonym: "TRAP protein" RELATED [] xref: GO:0016455 is_a: CCO:F0003090 ! general RNA polymerase II transcription factor activity [Term] id: CCO:F0003166 name: pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok xref: EC:3.6.1.- xref: GO:0016462 xref: Reactome:3222 is_a: CCO:F0003386 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: CCO:F0003167 name: zinc-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) = ADP + phosphate + Zn2+(out)." [EC:3.6.3.5] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "AtHMA4" RELATED [EC:3.6.3.5] synonym: "ATP phosphohydrolase (Zn2+-exporting)" EXACT [EC:3.6.3.5] synonym: "P(1B)-type ATPase activity" NARROW [EC:3.6.3.5] synonym: "P1B-type ATPase activity" EXACT [EC:3.6.3.5] synonym: "zinc exporting ATPase activity" EXACT [] synonym: "zinc-translocating P-type ATPase activity" BROAD [EC:3.6.3.5] synonym: "Zn(2+)-exporting ATPase activity" EXACT [EC:3.6.3.5] synonym: "Zn(II)-translocating P-type ATPase activity" EXACT [EC:3.6.3.5] synonym: "Zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5] synonym: "zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5] xref: EC:3.6.3.5 xref: GO:0016463 xref: MetaCyc:3.6.3.5-RXN is_a: CCO:F0001601 ! zinc ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0003168 name: chloroplast protein-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:3.6.3.52] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (chloroplast protein-importing)" EXACT [EC:3.6.3.52] synonym: "chloroplast protein ABC transporter" NARROW [] xref: EC:3.6.3.52 xref: GO:0016464 xref: MetaCyc:3.6.3.52-RXN is_a: CCO:F0002869 ! protein-transmembrane transporting ATPase activity [Term] id: CCO:F0003169 name: tryptophan hydroxylase activator activity namespace: molecular_function def: "Increases the activity of the enzyme tryptophase hydroxylase." [GOC:ai] xref: GO:0016483 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0003170 name: proprotein convertase 2 activator activity namespace: molecular_function def: "Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852] xref: GO:0016484 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0003171 name: structural constituent of peritrophic membrane namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents." [GOC:mtg_sensu, ISBN:0879694238] synonym: "structural constituent of peritrophic matrix (sensu Insecta)" EXACT [] synonym: "structural constituent of peritrophic membrane (sensu Insecta)" EXACT [] xref: GO:0016490 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0003172 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term. subset: goslim_candida subset: goslim_goa subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1 xref: GO:0016491 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0003173 name: neurotensin receptor activity, G-protein coupled namespace: molecular_function def: "G-protein coupled receptor for the tridecapeptide neurotensin. Associated with G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)." [UniProtKB:O95665] synonym: "G protein coupled neurotensin receptor activity" EXACT [] synonym: "G-protein coupled neurotensin receptor activity" EXACT [] synonym: "G-protein-coupled neurotensin receptor activity" EXACT [] synonym: "neurotensin receptor activity, G protein coupled" EXACT [] xref: GO:0016492 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0003174 name: C-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-C chemokine to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [PMID:8662823] xref: GO:0016493 is_a: CCO:F0001292 ! chemokine receptor activity is_a: CCO:F0004223 ! C-C chemokine binding [Term] id: CCO:F0003175 name: C-X-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-X-C chemokine to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [PMID:8662823] xref: GO:0016494 is_a: CCO:F0001292 ! chemokine receptor activity is_a: CCO:F0004224 ! C-X-C chemokine binding [Term] id: CCO:F0003176 name: C-X3-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-X3-C chemokine to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph] xref: GO:0016495 is_a: CCO:F0001292 ! chemokine receptor activity is_a: CCO:F0004226 ! C-X3-C chemokine binding [Term] id: CCO:F0003177 name: substance P receptor activity namespace: molecular_function def: "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0016496 is_a: CCO:F0001333 ! tachykinin receptor activity [Term] id: CCO:F0003178 name: substance K receptor activity namespace: molecular_function def: "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "neurokinin A receptor activity" EXACT [] synonym: "neuromedin L receptor activity" EXACT [] xref: GO:0016497 is_a: CCO:F0001333 ! tachykinin receptor activity [Term] id: CCO:F0003179 name: neuromedin K receptor activity namespace: molecular_function def: "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "neurokinin B receptor activity" EXACT [] xref: GO:0016498 is_a: CCO:F0001333 ! tachykinin receptor activity [Term] id: CCO:F0003180 name: orexin receptor activity namespace: molecular_function def: "Combining with orexin to initiate a change in cell activity." [GOC:ai] xref: GO:0016499 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0003181 name: protein-hormone receptor activity namespace: molecular_function def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] xref: GO:0016500 is_a: CCO:F0000141 ! rhodopsin-like receptor activity [Term] id: CCO:F0003182 name: prostacyclin receptor activity namespace: molecular_function def: "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGI receptor activity" RELATED [] synonym: "PGI(2) receptor activity" EXACT [] synonym: "prostaglandin I receptor activity" EXACT [] xref: GO:0004959 xref: GO:0016501 is_a: CCO:F0001297 ! prostaglandin receptor activity [Term] id: CCO:F0003183 name: nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0016502 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0003184 name: pheromone receptor activity namespace: molecular_function def: "Combining with a pheromone to initiate a change in cell activity." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0016503 is_a: CCO:F0001272 ! G-protein coupled receptor activity [Term] id: CCO:F0003185 name: protease activator activity namespace: molecular_function def: "Increases the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds." [GOC:ai] subset: gosubset_prok xref: GO:0016504 xref: Reactome:11526 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0003186 name: apoptotic protease activator activity namespace: molecular_function xref: GO:0016505 is_a: CCO:F0003185 ! protease activator activity [Term] id: CCO:F0003187 name: long-chain-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.74] synonym: "long-chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.74] synonym: "long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.74] xref: EC:4.2.1.74 xref: GO:0016508 xref: MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003188 name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+. Acts most rapidly on derivatives with chain length 8 or 10." [EC:1.1.1.211] comment: Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'. subset: gosubset_prok synonym: "beta-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.211] synonym: "LCHAD" RELATED [EC:1.1.1.211] synonym: "long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.211] synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.211] xref: EC:1.1.1.211 xref: GO:0016509 xref: MetaCyc:1.1.1.211-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003189 name: endothelin-converting enzyme activity namespace: molecular_function subset: gosubset_prok xref: GO:0016511 is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0003190 name: endothelin-converting enzyme 1 activity namespace: molecular_function def: "Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [EC:3.4.24.71] subset: gosubset_prok synonym: "ECE-1 activity" EXACT [EC:3.4.24.71] xref: EC:3.4.24.71 xref: GO:0016512 xref: MetaCyc:3.4.24.71-RXN is_a: CCO:F0003189 ! endothelin-converting enzyme activity [Term] id: CCO:F0003191 name: interleukin-13 receptor activity namespace: molecular_function def: "Combining with interleukin-13 to initiate a change in cell activity." [GOC:jl] synonym: "IL-13R" EXACT [] xref: GO:0016515 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004237 ! interleukin-13 binding [Term] id: CCO:F0003192 name: interleukin-12 receptor activity namespace: molecular_function def: "Combining with interleukin-12 to initiate a change in cell activity." [GOC:jl] synonym: "IL-12R" EXACT [] xref: GO:0016517 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004236 ! interleukin-12 binding [Term] id: CCO:F0003193 name: interleukin-14 receptor activity namespace: molecular_function def: "Combining with interleukin-14 to initiate a change in cell activity." [GOC:jl] synonym: "IL-14R" EXACT [] xref: GO:0016518 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004238 ! interleukin-14 binding [Term] id: CCO:F0003194 name: gastric inhibitory peptide receptor activity namespace: molecular_function def: "Combining with gastric inhibitory peptide to initiate a change in cell activity." [UniProtKB:P48546] xref: GO:0016519 is_a: CCO:F0000186 ! corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity [Term] id: CCO:F0003195 name: growth hormone-releasing hormone receptor activity namespace: molecular_function def: "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [UniProtKB:P32082] xref: GO:0016520 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0003196 name: pituitary adenylate cyclase activating polypeptide activity namespace: molecular_function synonym: "pituitary adenylyl cyclase activating polypeptide activity" EXACT [] xref: GO:0016521 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0003197 name: latrotoxin receptor activity namespace: molecular_function def: "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity." [GOC:jl, PMID:10025961] synonym: "latrophilin" NARROW [] xref: GO:0016524 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0003198 name: brain-specific angiogenesis inhibitor activity namespace: molecular_function xref: GO:0016527 is_a: CCO:F0000183 ! secretin-like receptor activity [Term] id: CCO:F0003199 name: metallochaperone activity namespace: molecular_function def: "Assists in the delivery of metal ions to target proteins or compartments." [GOC:jl, PMID:11739376] subset: goslim_pir subset: gosubset_prok xref: GO:0016530 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0003200 name: copper chaperone activity namespace: molecular_function def: "Assists in the delivery of copper ions to target proteins or compartments." [PMID:10790544, PMID:11739376] xref: GO:0016531 is_a: CCO:F0001644 ! copper ion binding is_a: CCO:F0003199 ! metallochaperone activity [Term] id: CCO:F0003201 name: superoxide dismutase copper chaperone activity namespace: molecular_function def: "A copper chaperone specifically delivering copper to the Cu-Zn superoxide dismutase." [http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:9295278] comment: See also the molecular function term 'copper, zinc superoxide dismutase activity ; GO:0004785'. xref: GO:0016532 is_a: CCO:F0003200 ! copper chaperone activity [Term] id: CCO:F0003202 name: cyclin-dependent protein kinase 5 activator activity namespace: molecular_function synonym: "cyclin-dependent protein kinase 5 activator, intrinsic catalyst activity" EXACT [] xref: GO:0016534 xref: GO:0016535 is_a: CCO:F0004382 ! protein kinase activator activity [Term] id: CCO:F0003203 name: cyclin-dependent protein kinase 5 activator regulator activity namespace: molecular_function def: "Modulation of the activity of cyclin-dependent protein kinase 5 activator." [GOC:ai] synonym: "cyclin-dependent protein kinase 5 activator, intrinsic regulator activity" NARROW [] xref: GO:0016536 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0003204 name: cyclin-dependent protein kinase regulator activity namespace: molecular_function def: "Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:rn, PMID:7877684, PMID:9442875] synonym: "cyclin" BROAD [] synonym: "cyclin-dependent protein kinase, intrinsic regulator activity" NARROW [] synonym: "G1/S-specific cyclin" NARROW [] synonym: "G2/M-specific cyclin" NARROW [] xref: EC:2.7.1.- xref: GO:0003751 xref: GO:0003752 xref: GO:0003753 xref: GO:0016538 is_a: CCO:F0004204 ! protein kinase regulator activity [Term] id: CCO:F0003205 name: transcription activator activity namespace: molecular_function def: "Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653] subset: gosubset_prok synonym: "transcription activating factor" NARROW [] synonym: "transcriptional activator activity" EXACT [] xref: GO:0003710 xref: GO:0016563 xref: Reactome:9388 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0003206 name: transcription repressor activity namespace: molecular_function def: "Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah] subset: gosubset_prok synonym: "negative transcriptional regulator activity" EXACT [] synonym: "transcriptional repressor activity" EXACT [] xref: GO:0016564 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0003207 name: general transcriptional repressor activity namespace: molecular_function def: "Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah] xref: GO:0016565 is_a: CCO:F0003206 ! transcription repressor activity [Term] id: CCO:F0003208 name: specific transcriptional repressor activity namespace: molecular_function def: "Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah] subset: gosubset_prok xref: GO:0016566 is_a: CCO:F0003206 ! transcription repressor activity [Term] id: CCO:F0003209 name: glycine binding namespace: molecular_function def: "Interacting selectively with glycine, aminoethanoic acid." [GOC:ai] synonym: "aminoacetic acid binding" EXACT [] synonym: "aminoethanoic acid binding" EXACT [] synonym: "Gly binding" EXACT [] xref: GO:0016594 is_a: CCO:F0003212 ! amino acid binding [Term] id: CCO:F0003210 name: glutamate binding namespace: molecular_function def: "Interacting selectively with glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai] synonym: "glutamic acid binding" EXACT [] xref: GO:0016595 is_a: CCO:F0003212 ! amino acid binding [Term] id: CCO:F0003211 name: thienylcyclohexylpiperidine binding namespace: molecular_function def: "Interacting selectively with thienylcyclohexylpiperidine." [GOC:jl] synonym: "TCP binding" BROAD [] xref: GO:0016596 is_a: CCO:F0001746 ! drug binding [Term] id: CCO:F0003212 name: amino acid binding namespace: molecular_function def: "Interacting selectively with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] subset: goslim_pir subset: gosubset_prok xref: GO:0016597 is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0003213 name: glutaminyl-peptide cyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5] subset: gosubset_prok synonym: "glutaminyl cyclase activity" EXACT [EC:2.3.2.5] synonym: "glutaminyl-transfer ribonucleate cyclotransferase activity" EXACT [EC:2.3.2.5] synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5] synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.5] xref: EC:2.3.2.5 xref: GO:0016603 xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0003214 name: growth hormone-releasing hormone activity namespace: molecular_function xref: GO:0016608 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0003215 name: G-protein coupled serotonin receptor activity namespace: molecular_function synonym: "G protein coupled serotonin receptor activity" EXACT [] synonym: "G-protein-coupled serotonin receptor activity" EXACT [] xref: GO:0016609 is_a: CCO:F0001331 ! serotonin receptor activity [Term] id: CCO:F0003216 name: oxidoreductase activity, acting on CH-OH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.1.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW [] xref: EC:1.1 xref: GO:0016614 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003217 name: malate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] subset: gosubset_prok xref: GO:0016615 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003218 name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.1.1 xref: GO:0016616 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003219 name: 4-oxoproline reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+." [EC:1.1.1.104] synonym: "4-hydroxy-L-proline:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.104] synonym: "hydroxy-L-proline oxidase activity" EXACT [] synonym: "hydroxyproline oxidase activity" EXACT [EC:1.1.1.104] xref: EC:1.1.1.104 xref: GO:0016617 xref: MetaCyc:4-OXOPROLINE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003220 name: hydroxypyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81] subset: gosubset_prok synonym: "beta-hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] synonym: "D-glycerate dehydrogenase activity" EXACT [EC:1.1.1.81] synonym: "D-glycerate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.81] synonym: "NADH:hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] xref: EC:1.1.1.81 xref: GO:0016618 xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003221 name: malate dehydrogenase (oxaloacetate-decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Also decarboxylates oxaloacetate." [EC:1.1.1.38] subset: gosubset_prok synonym: "'malic' enzyme" RELATED [EC:1.1.1.38] synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.38] synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38] synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38] synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38] xref: EC:1.1.1.38 xref: GO:0004472 xref: GO:0016619 xref: MetaCyc:MALIC-NAD-RXN is_a: CCO:F0000869 ! malic enzyme activity is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003222 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.2.1 xref: GO:0016620 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0003223 name: cinnamoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44] synonym: "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)" EXACT [EC:1.2.1.44] synonym: "cinnamoyl CoA reductase activity" EXACT [] synonym: "cinnamoyl-CoA:NADPH reductase activity" EXACT [EC:1.2.1.44] synonym: "cinnamoyl-coenzyme A reductase activity" EXACT [EC:1.2.1.44] synonym: "feruloyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] synonym: "feruloyl-CoA reductase activity" EXACT [EC:1.2.1.44] synonym: "ferulyl-CoA reductase activity" EXACT [EC:1.2.1.44] synonym: "p-hydroxycinnamoyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] xref: EC:1.2.1.44 xref: GO:0016621 xref: MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003224 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok xref: EC:1.2.2 xref: GO:0016622 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0003225 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.2.3 xref: GO:0016623 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0003226 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor" EXACT [] xref: EC:1.2.4 xref: GO:0016624 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0003227 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.2.7 xref: GO:0016625 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0003228 name: oxidoreductase activity, acting on the CH-CH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.3.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW [] xref: EC:1.3 xref: GO:0016627 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003229 name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.3.1 xref: GO:0016628 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003230 name: 12-oxophytodienoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 8-((1R,2R)-3-oxo-2-((Z)-pent-2-enyl)cyclopentyl)octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + NADPH." [EC:1.3.1.42] synonym: "12-oxo-phytodienoate reductase activity" EXACT [] synonym: "12-oxo-phytodienoic acid reductase activity" EXACT [EC:1.3.1.42] synonym: "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.42] xref: EC:1.3.1.42 xref: GO:0016629 xref: MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003231 name: protochlorophyllide reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33] subset: gosubset_prok synonym: "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH-protochlorophyllide reductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH2-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "protochlorophyllide photooxidoreductase activity" EXACT [EC:1.3.1.33] xref: EC:1.3.1.33 xref: GO:0016630 xref: MetaCyc:PROTOCHLOROPHYLLIDE-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003232 name: enoyl-[acyl-carrier-protein] reductase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [EC:1.3.1.9, GOC:rb] subset: gosubset_prok synonym: "acyl-ACP dehydrogenase activity" EXACT [EC:1.3.1.-] synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT [] synonym: "enoyl-ACP reductase activity" EXACT [] synonym: "enoyl-acyl carrier protein reductase" EXACT [] xref: EC:1.3.1.- xref: GO:0016631 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003233 name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.3.2 xref: GO:0016632 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003234 name: galactonolactone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3] synonym: "GLDase activity" EXACT [EC:1.3.2.3] synonym: "GLDHase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-1,4-lactone dehydrogenase activity" EXACT [] synonym: "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-gamma-lactone dehydrogenase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] synonym: "L-galactonolactone dehydrogenase activity" EXACT [EC:1.3.2.3] xref: EC:1.3.2.3 xref: GO:0016633 xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN is_a: CCO:F0003233 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor [Term] id: CCO:F0003235 name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.3.3 xref: GO:0016634 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003236 name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl] subset: gosubset_prok xref: EC:1.3.5 xref: GO:0016635 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003237 name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.3.7 xref: GO:0016636 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003238 name: oxidoreductase activity, acting on the CH-NH2 group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.4.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW [] xref: EC:1.4 xref: GO:0016638 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003239 name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.4.1 xref: GO:0016639 is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0003240 name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] xref: EC:1.4.2 xref: GO:0016640 is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0003241 name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.4.3 xref: GO:0016641 is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0003242 name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor" EXACT [] xref: EC:1.4.4 xref: GO:0016642 is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0003243 name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.4.7 xref: GO:0016643 is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0003244 name: oxidoreductase activity, acting on the CH-NH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.5.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW [] xref: EC:1.5 xref: GO:0016645 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003245 name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.5.1 xref: GO:0016646 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0003246 name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.5.3 xref: GO:0016647 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0003247 name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] synonym: "oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor" EXACT [] xref: EC:1.5.4 xref: GO:0016648 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0003248 name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl] subset: gosubset_prok xref: EC:1.5.5 xref: GO:0016649 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0003249 name: oxidoreductase activity, acting on NADH or NADPH namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.6.99.- should also be annotated to this term. subset: gosubset_prok synonym: "NAD(P)H dehydrogenase" NARROW [] synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW [] xref: EC:1.6 xref: GO:0016651 xref: Reactome:4134 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003250 name: oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.6.1 xref: GO:0016652 is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0003251 name: oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai] synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT [] xref: EC:1.6.2 xref: GO:0016653 is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0003252 name: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT [] xref: EC:1.6.4 xref: GO:0016654 is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0003253 name: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.6.5 xref: GO:0016655 is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0003254 name: monodehydroascorbate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate." [EC:1.6.5.4] synonym: "AFR" RELATED [EC:1.6.5.4] synonym: "AFR-reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbate free radical reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbate free-radical reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbic free radical reductase activity" EXACT [EC:1.6.5.4] synonym: "MDAsA reductase (NADPH)" EXACT [EC:1.6.5.4] synonym: "MDHA" RELATED [EC:1.6.5.4] synonym: "monodehydroascorbate reductase activity" EXACT [] synonym: "NADH-semidehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:AFR oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:ascorbate radical oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:monodehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:semidehydroascorbic acid oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "SDA reductase activity" EXACT [EC:1.6.5.4] synonym: "semidehydroascorbate reductase activity" EXACT [EC:1.6.5.4] xref: EC:1.6.5.4 xref: GO:0016656 xref: MetaCyc:1.6.5.4-RXN is_a: CCO:F0003253 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: CCO:F0003255 name: oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai] subset: gosubset_prok xref: EC:1.6.6 xref: GO:0016657 is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0003256 name: oxidoreductase activity, acting on other nitrogenous compounds as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.7.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" NARROW [] xref: EC:1.7 xref: GO:0016661 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003257 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok xref: EC:1.7.2 xref: GO:0016662 is_a: CCO:F0003256 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: CCO:F0003258 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.7.3 xref: GO:0016663 is_a: CCO:F0003256 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: CCO:F0003259 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.7.7 xref: GO:0016664 is_a: CCO:F0003256 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: CCO:F0003260 name: oxidoreductase activity, acting on sulfur group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.8.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW [] synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT [] xref: EC:1.8 xref: GO:0016667 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003261 name: oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT [] xref: EC:1.8.1 xref: GO:0016668 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0003262 name: oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor" EXACT [] xref: EC:1.8.2 xref: GO:0016669 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0003263 name: oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" EXACT [] xref: EC:1.8.3 xref: GO:0016670 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0003264 name: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor" EXACT [] xref: EC:1.8.4 xref: GO:0016671 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0003265 name: oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT [] xref: EC:1.8.5 xref: GO:0016672 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0003266 name: oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.8.7 xref: GO:0016673 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0003267 name: oxidoreductase activity, acting on heme group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.9.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on haem group of donors" EXACT [] synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW [] xref: EC:1.9 xref: GO:0016675 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003268 name: oxidoreductase activity, acting on heme group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT [] xref: EC:1.9. xref: GO:0016676 is_a: CCO:F0003267 ! oxidoreductase activity, acting on heme group of donors [Term] id: CCO:F0003269 name: oxidoreductase activity, acting on heme group of donors, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl] synonym: "oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor" EXACT [] xref: EC:1.9.6 xref: GO:0016677 is_a: CCO:F0003267 ! oxidoreductase activity, acting on heme group of donors [Term] id: CCO:F0003270 name: oxidoreductase activity, acting on diphenols and related substances as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.10.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW [] xref: EC:1.10 xref: GO:0016679 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003271 name: oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.10.1 xref: GO:0016680 is_a: CCO:F0003270 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: CCO:F0003272 name: oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok xref: EC:1.10.2 xref: GO:0016681 is_a: CCO:F0003270 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: CCO:F0003273 name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.10.3 xref: GO:0016682 is_a: CCO:F0003270 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: CCO:F0003274 name: oxidoreductase activity, acting on peroxide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok xref: EC:1.11 xref: GO:0016684 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003275 name: L-ascorbate peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate + H2O2 = dehydroascorbate + 2 H2O." [EC:1.11.1.11] synonym: "ascorbate peroxidase activity" EXACT [EC:1.11.1.11] synonym: "ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbic acid-specific peroxidase activity" EXACT [EC:1.11.1.11] xref: EC:1.11.1.11 xref: GO:0016688 xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0003276 name: manganese peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Mn2+ + 2 H+ + H2O2 = 2 Mn3+ + 2 H2O." [EC:1.11.1.13] synonym: "Mn(II):hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.13] synonym: "Mn-dependent (NADH-oxidizing) peroxidase activity" EXACT [EC:1.11.1.13] synonym: "Mn-dependent peroxidase activity" EXACT [EC:1.11.1.13] synonym: "peroxidase-M2" RELATED [EC:1.11.1.13] xref: EC:1.11.1.13 xref: GO:0016689 xref: MetaCyc:MANGANESE-PEROXIDASE-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0003277 name: diarylpropane peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 = veratraldehyde + 1-(3,4-dimethylphenyl)ethane-1,2-diol + 4 H2O." [EC:1.11.1.14] synonym: "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.14] synonym: "diarylpropane oxygenase activity" EXACT [EC:1.11.1.14] synonym: "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.11.1.14] synonym: "lignin peroxidase activity" EXACT [EC:1.11.1.14] synonym: "ligninase activity" EXACT [EC:1.11.1.14] synonym: "ligninase I activity" NARROW [EC:1.11.1.14] synonym: "LiP activity" NARROW [EC:1.11.1.14] xref: EC:1.11.1.14 xref: GO:0016690 xref: MetaCyc:DIARYLPROPANE-PEROXIDASE-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0003278 name: chloride peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 R-H + 2 chloride + H2O2 = 2 R-Cl + 2 H2O." [EC:1.11.1.10] subset: gosubset_prok synonym: "chloride:hydrogen-peroxide oxidoreductase" EXACT [EC:1.11.1.10] synonym: "chloroperoxidase activity" EXACT [EC:1.11.1.10] synonym: "cofactor-free chloroperoxidase activity" NARROW [] synonym: "flavin-haem chloroperoxidase activity" NARROW [] synonym: "flavin-heme chloroperoxidase activity" NARROW [] synonym: "haem chloroperoxidase activity" NARROW [] synonym: "heme chloroperoxidase activity" NARROW [] synonym: "vanadium chloroperoxidase activity" NARROW [] xref: EC:1.11.1.10 xref: GO:0016691 xref: GO:0016955 xref: GO:0016956 xref: GO:0016957 xref: GO:0016958 xref: MetaCyc:CHLORIDE-PEROXIDASE-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0003279 name: NADH peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + H2O2 = NAD+ + 2 H2O." [EC:1.11.1.1] subset: gosubset_prok synonym: "diphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.1] synonym: "DPNH peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NAD peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NADH-peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NADH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.1] synonym: "nicotinamide adenine dinucleotide peroxidase activity" EXACT [EC:1.11.1.1] xref: EC:1.11.1.1 xref: GO:0016692 xref: MetaCyc:NADH-PEROXIDASE-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0003280 name: secretory plant peroxidase activity namespace: molecular_function xref: EC:1.11.1.- xref: GO:0016693 is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0003281 name: oxidoreductase activity, acting on hydrogen as donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl] comment: Note that enzymes of class EC:1.12.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" NARROW [] xref: EC:1.12 xref: GO:0016695 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003282 name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.12.1 xref: GO:0016696 is_a: CCO:F0003281 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: CCO:F0003283 name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok xref: EC:1.12.2 xref: GO:0016697 xref: GO:0016698 is_a: CCO:F0003281 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: CCO:F0003284 name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.12.7 xref: GO:0016699 is_a: CCO:F0003281 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: CCO:F0003285 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah] comment: Note that enzymes of class EC:1.13.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" NARROW [] synonym: "oxygenase" BROAD [] xref: EC:1.13 xref: GO:0016701 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003286 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah] subset: gosubset_prok xref: EC:1.13.11 xref: GO:0016702 is_a: CCO:F0003285 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: CCO:F0008070 ! dioxygenase activity [Term] id: CCO:F0003287 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [GOC:mah] subset: gosubset_prok xref: EC:1.13.12 xref: GO:0016703 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003285 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: CCO:F0003288 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] comment: Note that enzymes of class EC:1.14.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" NARROW [] xref: EC:1.14 xref: GO:0016705 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003289 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.11 xref: GO:0016706 xref: Reactome:726 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003290 name: gibberellin 3-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin 20 + 2-oxoglutarate + O2 = gibberellin 1 + succinate + CO2." [EC:1.14.11.15] synonym: "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)" EXACT [EC:1.14.11.15] synonym: "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)" EXACT [EC:1.14.11.15] synonym: "gibberellin 3-beta-hydroxylase activity" EXACT [EC:1.14.11.15] synonym: "gibberellin 3beta-dioxygenase activity" EXACT [EC:1.14.11.15] synonym: "gibberellin 3beta-hydroxylase activity" EXACT [EC:1.14.11.15] xref: EC:1.14.11.15 xref: GO:0016707 xref: MetaCyc:GIBBERELLIN-3-BETA-DIOXYGENASE-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0003291 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.12 xref: GO:0016708 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: CCO:F0008070 ! dioxygenase activity [Term] id: CCO:F0003292 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.13 xref: GO:0016709 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003293 name: trans-cinnamate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.11] synonym: "CA4H activity" NARROW [EC:1.14.13.11] synonym: "cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamate 4-monooxygenase activity" EXACT [EC:1.14.13.11] synonym: "cinnamate hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic acid 4-monooxygenase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic acid p-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cytochrome P450 cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "hydroxylase, cinnamate 4-" EXACT [EC:1.14.13.11] synonym: "oxygenase, cinnamate 4-mono-" EXACT [EC:1.14.13.11] synonym: "t-cinnamic acid hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "trans-cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.11] synonym: "trans-cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11] xref: EC:1.14.13.11 xref: GO:0016710 xref: MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003294 name: flavonoid 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.13.21] synonym: "flavonoid 3'-hydroxylase activity" EXACT [EC:1.14.13.21] synonym: "flavonoid 3-hydroxylase (erroneous)" EXACT [EC:1.14.13.21] synonym: "flavonoid 3-monooxygenase (erroneous)" EXACT [EC:1.14.13.21] synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.21] synonym: "NADPH:flavonoid-3'-hydroxylase activity" EXACT [EC:1.14.13.21] xref: EC:1.14.13.21 xref: GO:0016711 xref: MetaCyc:FLAVONOID-3 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003295 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.14 xref: GO:0016712 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003296 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen" EXACT [] xref: EC:1.14.15 xref: GO:0016713 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003297 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.16 xref: GO:0016714 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003298 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.17 xref: GO:0016715 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003299 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.18 xref: GO:0016716 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003300 name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] subset: gosubset_prok xref: EC:1.14.19 xref: GO:0016717 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003301 name: carotene 7,8-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O." [EC:1.14.99.30] subset: gosubset_prok synonym: "carotene,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.30] synonym: "zeta-carotene desaturase activity" EXACT [EC:1.14.99.30] xref: EC:1.14.99.30 xref: GO:0016719 xref: MetaCyc:1.14.99.30-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003302 name: delta12-fatty acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + donor-H2 + O2 = crepenynate + acceptor + H2O." [EC:1.14.99.33] synonym: "crepenynate synthase activity" NARROW [EC:1.14.99.33] synonym: "D12-fatty acid dehydrogenase activity" EXACT [] synonym: "delta-12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] synonym: "delta12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] synonym: "linoleate delta-12-fatty acid acetylenase (desaturase) activity" EXACT [] synonym: "linoleate delta12-fatty acid acetylenase (desaturase)" EXACT [EC:1.14.99.33] synonym: "linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)" EXACT [EC:1.14.99.33] xref: EC:1.14.99.33 xref: GO:0016720 xref: MetaCyc:1.14.99.33-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003303 name: oxidoreductase activity, acting on superoxide radicals as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok xref: EC:1.15 xref: GO:0016721 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003304 name: oxidoreductase activity, oxidizing metal ions namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah] subset: gosubset_prok xref: EC:1.16 xref: GO:0016722 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003305 name: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah] subset: gosubset_prok xref: EC:1.16.1 xref: GO:0016723 is_a: CCO:F0003304 ! oxidoreductase activity, oxidizing metal ions [Term] id: CCO:F0003306 name: oxidoreductase activity, oxidizing metal ions, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah] subset: gosubset_prok xref: EC:1.16.3 xref: GO:0016724 is_a: CCO:F0003304 ! oxidoreductase activity, oxidizing metal ions [Term] id: CCO:F0003307 name: oxidoreductase activity, acting on CH or CH2 groups namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.17.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on CH or CH2 groups, other acceptors" NARROW [] xref: EC:1.17 xref: GO:0016725 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003308 name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.17.1 xref: GO:0016726 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0003309 name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.17.3 xref: GO:0016727 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0003310 name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor" EXACT [] xref: EC:1.17.4 xref: GO:0016728 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0003311 name: oxidoreductase activity, acting on iron-sulfur proteins as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on iron-sulphur proteins as donors" EXACT [] xref: EC:1.18 xref: GO:0016730 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003312 name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.18.1 xref: GO:0016731 is_a: CCO:F0003311 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: CCO:F0003313 name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] subset: gosubset_prok xref: EC:1.18.6 xref: GO:0016732 is_a: CCO:F0003311 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: CCO:F0003314 name: oxidoreductase activity, acting on reduced flavodoxin as donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok xref: EC:1.19 xref: GO:0016737 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003315 name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] subset: gosubset_prok xref: EC:1.19.6 xref: GO:0016738 is_a: CCO:F0003314 ! oxidoreductase activity, acting on reduced flavodoxin as donor [Term] id: CCO:F0003316 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: EC:2 xref: GO:0016740 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0003317 name: transferase activity, transferring one-carbon groups namespace: molecular_function def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.1 xref: GO:0016741 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0003318 name: hydroxymethyl-, formyl- and related transferase activity namespace: molecular_function subset: gosubset_prok xref: EC:2.1.2 xref: GO:0016742 is_a: CCO:F0000791 ! glycine hydroxymethyltransferase activity [Term] id: CCO:F0003319 name: carboxyl- or carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "carboxyl- and carbamoyltransferase activity" EXACT [] xref: EC:2.1.3 xref: GO:0016743 is_a: CCO:F0003317 ! transferase activity, transferring one-carbon groups [Term] id: CCO:F0003320 name: transferase activity, transferring aldehyde or ketonic groups namespace: molecular_function def: "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "transketolase or transaldolase activity" EXACT [] xref: EC:2.2 xref: EC:2.2.1 xref: GO:0016744 xref: GO:0016745 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0003321 name: transferase activity, transferring acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.3 xref: GO:0016746 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0003322 name: transferase activity, transferring groups other than amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.3.1 xref: GO:0016747 xref: Reactome:1087 is_a: CCO:F0003321 ! transferase activity, transferring acyl groups [Term] id: CCO:F0003323 name: succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016748 xref: Reactome:1089 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003324 name: N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016749 is_a: CCO:F0003133 ! N-acyltransferase activity is_a: CCO:F0003323 ! succinyltransferase activity [Term] id: CCO:F0003325 name: O-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016750 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0003323 ! succinyltransferase activity [Term] id: CCO:F0003326 name: S-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an succinyl group to a sulfur atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0016751 is_a: CCO:F0003140 ! S-acyltransferase activity is_a: CCO:F0003323 ! succinyltransferase activity [Term] id: CCO:F0003327 name: sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an sinapoyl group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0016752 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003328 name: O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0016753 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0003327 ! sinapoyltransferase activity [Term] id: CCO:F0003329 name: sinapoylglucose-malate O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + (S)-malate = D-glucose + sinapoyl-(S)-malate." [EC:2.3.1.92] synonym: "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity" EXACT [EC:2.3.1.92] synonym: "1-sinapoylglucose-L-malate sinapoyltransferase activity" EXACT [EC:2.3.1.92] synonym: "sinapoylglucose:malate sinapoyltransferase activity" EXACT [] xref: EC:2.3.1.92 xref: GO:0016754 xref: MetaCyc:2.3.1.92-RXN is_a: CCO:F0003328 ! O-sinapoyltransferase activity [Term] id: CCO:F0003330 name: transferase activity, transferring amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "aminoacyltransferase activity" EXACT [] xref: EC:2.3.2 xref: GO:0016755 is_a: CCO:F0003321 ! transferase activity, transferring acyl groups [Term] id: CCO:F0003331 name: glutathione gamma-glutamylcysteinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15] synonym: "gamma-glutamylcysteine dipeptidyl transpeptidase activity" EXACT [EC:2.3.2.15] synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity" EXACT [EC:2.3.2.15] synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15] xref: EC:2.3.2.15 xref: GO:0016756 xref: GO:0042143 xref: MetaCyc:2.3.2.15-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0003332 name: transferase activity, transferring glycosyl groups namespace: molecular_function def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that enzymes of class EC:2.4.99.- should also be annotated to this term. subset: gosubset_prok synonym: "glycosyltransferase activity" EXACT [] synonym: "transferase activity, transferring other glycosyl groups" NARROW [] synonym: "transglycosylase activity" EXACT [] xref: EC:2.4 xref: GO:0016757 xref: GO:0016932 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0003333 name: transferase activity, transferring hexosyl groups namespace: molecular_function def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "hexosyltransferase activity" EXACT [] xref: EC:2.4.1 xref: GO:0016758 is_a: CCO:F0003332 ! transferase activity, transferring glycosyl groups [Term] id: CCO:F0003334 name: cellulose synthase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12, EC:2.4.1.29] subset: gosubset_prok synonym: "cellulose synthetase activity" EXACT [EC:2.4.1.29] xref: EC:2.4.1.- xref: GO:0016759 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0003335 name: cellulose synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12] subset: gosubset_prok synonym: "1,4-beta-D-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "1,4-beta-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucan synthetase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "beta-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "GS-I" RELATED [EC:2.4.1.12] synonym: "UDP-glucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] xref: EC:2.4.1.12 xref: GO:0016760 xref: MetaCyc:CELLULOSE-SYNTHASE-(UDP-FORMING)-RXN is_a: CCO:F0003334 ! cellulose synthase activity is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0003336 name: cellulose synthase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29] synonym: "cellulose synthase (guanosine diphosphate-forming) activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] xref: EC:2.4.1.29 xref: GO:0016761 xref: MetaCyc:CELLULOSE-SYNTHASE-(GDP-FORMING)-RXN is_a: CCO:F0003334 ! cellulose synthase activity [Term] id: CCO:F0003337 name: xyloglucan:xyloglucosyl transferase activity namespace: molecular_function def: "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207] synonym: "endo-xyloglucan transferase activity" EXACT [EC:2.4.1.207] synonym: "endoxyloglucan transferase activity" EXACT [] synonym: "xyloglucan endotransglycosylase activity" EXACT [EC:2.4.1.207] synonym: "xyloglucan:xyloglucan xyloglucanotransferase activity" EXACT [EC:2.4.1.207] xref: EC:2.4.1.207 xref: GO:0016762 xref: MetaCyc:2.4.1.207-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0003338 name: transferase activity, transferring pentosyl groups namespace: molecular_function def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "pentosyltransferase activity" EXACT [] xref: EC:2.4.2 xref: GO:0016763 xref: Reactome:1245 is_a: CCO:F0003332 ! transferase activity, transferring glycosyl groups [Term] id: CCO:F0003339 name: transferase activity, transferring alkyl or aryl (other than methyl) groups namespace: molecular_function def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT [] xref: EC:2.5 xref: GO:0016765 xref: GO:0016766 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0003340 name: geranylgeranyl-diphosphate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [EC:2.5.1.32] subset: gosubset_prok synonym: "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.32] synonym: "phytoene synthetase activity" EXACT [EC:2.5.1.32] synonym: "prephytoene-diphosphate synthase activity" EXACT [EC:2.5.1.32] synonym: "PSase activity" EXACT [EC:2.5.1.32] xref: EC:2.5.1.32 xref: GO:0016767 xref: MetaCyc:2.5.1.32-RXN is_a: CCO:F0000756 ! geranyltranstransferase activity [Term] id: CCO:F0003341 name: spermine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22] synonym: "S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.22] synonym: "spermidine aminopropyltransferase activity" EXACT [EC:2.5.1.22] synonym: "spermine synthetase activity" EXACT [EC:2.5.1.22] xref: EC:2.5.1.22 xref: GO:0016768 xref: MetaCyc:SPERMINE-SYNTHASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0003342 name: transferase activity, transferring nitrogenous groups namespace: molecular_function def: "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that enzymes of class EC:2.6.99.- should also be annotated to this term. subset: gosubset_prok synonym: "transferase activity, transferring other nitrogenous groups" NARROW [] xref: EC:2.6 xref: GO:0016769 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0003343 name: oximinotransaminase activity namespace: molecular_function def: "Catalysis of the reversible transfer of an oxime group to an acceptor." [GOC:ai] xref: EC:2.6.3 xref: GO:0016770 is_a: CCO:F0003342 ! transferase activity, transferring nitrogenous groups [Term] id: CCO:F0003344 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: gosubset_prok xref: EC:2.7 xref: GO:0016772 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0003345 name: phosphotransferase activity, alcohol group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.1 xref: GO:0016773 is_a: CCO:F0003344 ! transferase activity, transferring phosphorus-containing groups [Term] id: CCO:F0003346 name: phosphotransferase activity, carboxyl group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.2 xref: GO:0016774 is_a: CCO:F0003344 ! transferase activity, transferring phosphorus-containing groups [Term] id: CCO:F0003347 name: phosphotransferase activity, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.3 xref: GO:0016775 is_a: CCO:F0003344 ! transferase activity, transferring phosphorus-containing groups [Term] id: CCO:F0003348 name: phosphotransferase activity, phosphate group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.4 xref: GO:0016776 is_a: CCO:F0003344 ! transferase activity, transferring phosphorus-containing groups [Term] id: CCO:F0003349 name: phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers namespace: molecular_function xref: EC:2.7.5 xref: GO:0016777 is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0003350 name: diphosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] subset: gosubset_prok xref: EC:2.7.6 xref: GO:0016778 is_a: CCO:F0003344 ! transferase activity, transferring phosphorus-containing groups [Term] id: CCO:F0003351 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_yeast subset: gosubset_prok xref: EC:2.7.7 xref: GO:0016779 is_a: CCO:F0003344 ! transferase activity, transferring phosphorus-containing groups [Term] id: CCO:F0003352 name: phosphotransferase activity, for other substituted phosphate groups namespace: molecular_function def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] subset: gosubset_prok xref: EC:2.7.8 xref: GO:0016780 xref: Reactome:1452 is_a: CCO:F0003344 ! transferase activity, transferring phosphorus-containing groups [Term] id: CCO:F0003353 name: phosphotransferase activity, paired acceptors namespace: molecular_function def: "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] subset: gosubset_prok xref: EC:2.7.9 xref: GO:0016781 is_a: CCO:F0003344 ! transferase activity, transferring phosphorus-containing groups [Term] id: CCO:F0003354 name: transferase activity, transferring sulfur-containing groups namespace: molecular_function def: "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "transferase activity, transferring sulphur-containing groups" EXACT [] xref: EC:2.8 xref: GO:0016782 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0003355 name: sulfurtransferase activity namespace: molecular_function def: "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "sulphurtransferase activity" EXACT [] xref: EC:2.8.1 xref: GO:0016783 is_a: CCO:F0003354 ! transferase activity, transferring sulfur-containing groups [Term] id: CCO:F0003356 name: 3-mercaptopyruvate sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate." [EC:2.8.1.2] subset: gosubset_prok synonym: "3-mercaptopyruvate sulphurtransferase activity" EXACT [] synonym: "3-mercaptopyruvate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.2] synonym: "beta-mercaptopyruvate sulfurtransferase activity" EXACT [EC:2.8.1.2] synonym: "mercaptopyruvate sulfurtransferase activity" EXACT [] xref: EC:2.8.1.2 xref: GO:0016784 xref: MetaCyc:MERCAPYSTRANS-RXN is_a: CCO:F0003355 ! sulfurtransferase activity [Term] id: CCO:F0003357 name: transferase activity, transferring selenium-containing groups namespace: molecular_function def: "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.9 xref: GO:0016785 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0003358 name: selenotransferase activity namespace: molecular_function subset: gosubset_prok xref: EC:2.9.1 xref: GO:0016786 is_a: CCO:F0003357 ! transferase activity, transferring selenium-containing groups [Term] id: CCO:F0003359 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: EC:3 xref: GO:0016787 xref: Reactome:450 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0003360 name: hydrolase activity, acting on ester bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl] subset: gosubset_prok synonym: "esterase activity" EXACT [] xref: EC:3.1 xref: GO:0016788 xref: Reactome:448 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003361 name: thiolester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com] subset: gosubset_prok synonym: "thiolesterase activity" EXACT [] xref: EC:3.1.2 xref: GO:0016790 is_a: CCO:F0003360 ! hydrolase activity, acting on ester bonds [Term] id: CCO:F0003362 name: phosphoric monoester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "phosphatase" RELATED [] synonym: "phosphatase activity" EXACT [] xref: EC:3.1.3 xref: GO:0016302 xref: GO:0016791 is_a: CCO:F0005685 ! phosphoric ester hydrolase activity [Term] id: CCO:F0003363 name: triphosphoric monoester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai] subset: gosubset_prok xref: EC:3.1.5 xref: GO:0016793 is_a: CCO:F0005685 ! phosphoric ester hydrolase activity [Term] id: CCO:F0003364 name: diphosphoric monoester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group." [GOC:ai] subset: gosubset_prok xref: EC:3.1.7 xref: GO:0016794 is_a: CCO:F0005685 ! phosphoric ester hydrolase activity [Term] id: CCO:F0003365 name: phosphoric triester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a phosphoric triester." [http://cancerweb.ncl.ac.uk/] xref: EC:3.1.8 xref: GO:0016795 is_a: CCO:F0005685 ! phosphoric ester hydrolase activity [Term] id: CCO:F0003366 name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.15 xref: GO:0016796 is_a: CCO:F0000923 ! exonuclease activity [Term] id: CCO:F0003367 name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok xref: EC:3.1.16 xref: GO:0016797 is_a: CCO:F0000923 ! exonuclease activity [Term] id: CCO:F0003368 name: hydrolase activity, acting on glycosyl bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] subset: gosubset_prok synonym: "glycosylase" NARROW [] synonym: "N-glycosylase" NARROW [] xref: EC:3.2 xref: GO:0016798 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003369 name: hydrolase activity, hydrolyzing N-glycosyl compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl] subset: gosubset_prok xref: EC:3.2.2 xref: GO:0016799 is_a: CCO:F0003368 ! hydrolase activity, acting on glycosyl bonds [Term] id: CCO:F0003370 name: hydrolase activity, hydrolyzing S-glycosyl compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any S-glycosyl bond." [GOC:mah] xref: EC:3.2.3.- xref: GO:0016800 is_a: CCO:F0003368 ! hydrolase activity, acting on glycosyl bonds [Term] id: CCO:F0003371 name: hydrolase activity, acting on ether bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl] subset: gosubset_prok xref: EC:3.3 xref: GO:0016801 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003372 name: trialkylsulfonium hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a thioether bond, -S-." [EC:3.3.1.-, GOC:ai] subset: gosubset_prok synonym: "thioether hydrolase activity" EXACT [] synonym: "trialkylsulphonium hydrolase activity" EXACT [] xref: EC:3.3.1.- xref: GO:0016802 is_a: CCO:F0003371 ! hydrolase activity, acting on ether bonds [Term] id: CCO:F0003373 name: ether hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai] subset: gosubset_prok xref: EC:3.3.2 xref: GO:0016803 is_a: CCO:F0003371 ! hydrolase activity, acting on ether bonds [Term] id: CCO:F0003374 name: prolyl aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5] subset: gosubset_prok synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5] synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5] synonym: "proline iminopeptidase activity" EXACT [] xref: EC:3.4.11.5 xref: GO:0016804 xref: MetaCyc:3.4.11.5-RXN is_a: CCO:F0000646 ! aminopeptidase activity [Term] id: CCO:F0003375 name: dipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com] subset: gosubset_prok xref: EC:3.4.13 xref: GO:0016805 is_a: CCO:F0001788 ! exopeptidase activity [Term] id: CCO:F0003376 name: dipeptidyl-peptidase and tripeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai] subset: gosubset_prok xref: EC:3.4.14 xref: GO:0016806 is_a: CCO:F0001788 ! exopeptidase activity [Term] id: CCO:F0003377 name: cysteine-type carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center." [EC:3.4.18.-, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: EC:3.4.18 xref: GO:0016807 is_a: CCO:F0000649 ! carboxypeptidase activity is_a: CCO:F0001784 ! cysteine-type peptidase activity [Term] id: CCO:F0003378 name: proprotein convertase activity namespace: molecular_function xref: EC:3.4.21.- xref: GO:0016808 is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0003379 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] comment: Note that enzymes of class EC:3.5.99.- should also be annotated to this term. subset: gosubset_prok synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] xref: EC:3.5 xref: GO:0016810 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003380 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] subset: gosubset_prok xref: EC:3.5.1 xref: GO:0016811 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0003381 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai] subset: gosubset_prok xref: EC:3.5.2 xref: GO:0016812 xref: Reactome:2753 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0003382 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.5.3 xref: GO:0016813 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0003383 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.5.4 xref: GO:0016814 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0003384 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [http://www.onelook.com/] subset: gosubset_prok xref: EC:3.5.5 xref: GO:0016815 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0003385 name: hydrolase activity, acting on acid anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] subset: gosubset_prok synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] xref: EC:3.6 xref: GO:0016817 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003386 name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] subset: gosubset_prok xref: EC:3.6.1 xref: GO:0016818 is_a: CCO:F0003385 ! hydrolase activity, acting on acid anhydrides [Term] id: CCO:F0003387 name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai] synonym: "hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides" EXACT [] xref: EC:3.6.2 xref: GO:0016819 is_a: CCO:F0003385 ! hydrolase activity, acting on acid anhydrides [Term] id: CCO:F0003388 name: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances namespace: molecular_function def: "Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah] subset: gosubset_prok xref: EC:3.6.3 xref: GO:0016820 is_a: CCO:F0003385 ! hydrolase activity, acting on acid anhydrides [Term] id: CCO:F0003389 name: hydrolase activity, acting on acid carbon-carbon bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-carbon bond." [GOC:jl] subset: gosubset_prok xref: EC:3.7 xref: GO:0016822 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003390 name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [GOC:ai] subset: gosubset_prok xref: EC:3.7.1 xref: GO:0016823 is_a: CCO:F0003389 ! hydrolase activity, acting on acid carbon-carbon bonds [Term] id: CCO:F0003391 name: hydrolase activity, acting on acid halide bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid halide bond." [GOC:jl] subset: gosubset_prok xref: EC:3.8 xref: GO:0016824 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003392 name: hydrolase activity, acting on acid phosphorus-nitrogen bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl] xref: EC:3.9 xref: GO:0016825 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003393 name: hydrolase activity, acting on acid sulfur-nitrogen bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond." [GOC:jl] synonym: "hydrolase activity, acting on acid sulphur-nitrogen bonds" EXACT [] xref: EC:3.10 xref: GO:0016826 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003394 name: hydrolase activity, acting on acid carbon-phosphorus bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-phosphorus bond." [GOC:jl] subset: gosubset_prok xref: EC:3.11 xref: GO:0016827 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003395 name: hydrolase activity, acting on acid sulfur-sulfur bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid sulfur-sulfur bond." [GOC:jl] synonym: "hydrolase activity, acting on acid sulphur-sulphur bonds" EXACT [] xref: EC:3.12 xref: GO:0016828 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003396 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term. subset: goslim_candida subset: goslim_goa subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "other lyase activity" NARROW [] xref: EC:4 xref: GO:0016829 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0003397 name: carbon-carbon lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] comment: Note that enzymes of class EC:4.1.99.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-carbon lyase activity" NARROW [] xref: EC:4.1 xref: GO:0016830 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0003398 name: carboxy-lyase activity namespace: molecular_function def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/] subset: gosubset_prok synonym: "decarboxylase activity" EXACT [] xref: EC:4.1.1 xref: GO:0016831 xref: Reactome:1605 is_a: CCO:F0003397 ! carbon-carbon lyase activity [Term] id: CCO:F0003399 name: aldehyde-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/] subset: gosubset_prok synonym: "aldolase activity" BROAD [] xref: EC:4.1.2 xref: GO:0016228 xref: GO:0016832 is_a: CCO:F0003397 ! carbon-carbon lyase activity [Term] id: CCO:F0003400 name: oxo-acid-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3, GOC:jl] subset: gosubset_prok xref: EC:4.1.3 xref: GO:0016833 is_a: CCO:F0003397 ! carbon-carbon lyase activity [Term] id: CCO:F0003401 name: carbon-oxygen lyase activity namespace: molecular_function def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-] comment: Note that enzymes of class EC:4.2.99.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-oxygen lyase activity" NARROW [] xref: EC:4.2 xref: GO:0016835 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0003402 name: hydro-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1] subset: gosubset_prok xref: EC:4.2.1 xref: GO:0016836 is_a: CCO:F0003401 ! carbon-oxygen lyase activity [Term] id: CCO:F0003403 name: carbon-oxygen lyase activity, acting on polysaccharides namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [EC:4.2.-.-] subset: gosubset_prok xref: EC:4.2.2 xref: GO:0016837 is_a: CCO:F0003401 ! carbon-oxygen lyase activity [Term] id: CCO:F0003404 name: carbon-oxygen lyase activity, acting on phosphates namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [EC:4.2.-.-] subset: gosubset_prok xref: EC:4.2.3 xref: GO:0016838 is_a: CCO:F0003401 ! carbon-oxygen lyase activity [Term] id: CCO:F0003405 name: carbon-nitrogen lyase activity namespace: molecular_function def: "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-] comment: Note that enzymes of class EC:4.3.99.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-nitrogen lyase activity" NARROW [] xref: EC:4.3 xref: GO:0016840 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0003406 name: ammonia-lyase activity namespace: molecular_function def: "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc] subset: gosubset_prok xref: EC:4.3.1 xref: GO:0016841 is_a: CCO:F0003405 ! carbon-nitrogen lyase activity [Term] id: CCO:F0003407 name: amidine-lyase activity namespace: molecular_function def: "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc] subset: gosubset_prok xref: EC:4.3.2 xref: GO:0016842 is_a: CCO:F0003405 ! carbon-nitrogen lyase activity [Term] id: CCO:F0003408 name: amine-lyase activity namespace: molecular_function def: "Catalysis of the release of amides by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [EC:4.3.-.-, GOC:krc] subset: gosubset_prok xref: EC:4.3.3 xref: GO:0016843 is_a: CCO:F0003405 ! carbon-nitrogen lyase activity [Term] id: CCO:F0003409 name: strictosidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin." [EC:4.3.3.2] subset: gosubset_prok synonym: "3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.2] synonym: "3-alpha(S)-strictosidine tryptamine-lyase activity" EXACT [EC:4.3.3.2] synonym: "STR activity" EXACT [EC:4.3.3.2] synonym: "strictosidine synthetase activity" EXACT [EC:4.3.3.2] xref: EC:4.3.3.2 xref: GO:0016844 xref: MetaCyc:STRICTOSIDINE-SYNTHASE-RXN is_a: CCO:F0003408 ! amine-lyase activity [Term] id: CCO:F0003410 name: carbon-sulfur lyase activity namespace: molecular_function def: "Catalysis of the elimination of H2S or substituted H2S." [EC:4.4.-.-] subset: gosubset_prok synonym: "carbon-sulphur lyase activity" EXACT [] xref: EC:4.4 xref: GO:0016846 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0003411 name: 1-aminocyclopropane-1-carboxylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine." [EC:4.4.1.14] subset: gosubset_prok synonym: "1-aminocyclopropane-1-carboxylate synthetase activity" EXACT [EC:4.4.1.14] synonym: "1-aminocyclopropane-1-carboxylic acid synthase activity" EXACT [EC:4.4.1.14] synonym: "1-aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] synonym: "ACC synthase activity" EXACT [EC:4.4.1.14] synonym: "aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] synonym: "aminocyclopropanecarboxylic acid synthase activity" EXACT [EC:4.4.1.14] synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)" EXACT [EC:4.4.1.14] synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase activity" EXACT [EC:4.4.1.14] xref: EC:4.4.1.14 xref: GO:0016847 xref: MetaCyc:4.4.1.14-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0003412 name: carbon-halide lyase activity namespace: molecular_function def: "Catalysis of the breakage of a bond between carbon and any halogen atom." [GOC:mah] subset: gosubset_prok xref: EC:4.5 xref: GO:0016848 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0003413 name: phosphorus-oxygen lyase activity namespace: molecular_function subset: gosubset_prok xref: EC:4.6 xref: GO:0016849 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0003414 name: magnesium chelatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+." [EC:6.6.1.1] comment: Note that this was EC:4.99.1.1. subset: gosubset_prok synonym: "magnesium-chelatase activity" EXACT [EC:6.6.1.1] synonym: "magnesium-protoporphyrin chelatase activity" EXACT [EC:6.6.1.1] synonym: "magnesium-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] synonym: "Mg-chelatase activity" BROAD [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX magnesio-lyase activity" EXACT [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX magnesium-lyase activity" EXACT [EC:6.6.1.1] synonym: "protoporphyrin IX magnesium-chelatase activity" EXACT [EC:6.6.1.1] synonym: "protoporphyrin IX Mg-chelatase activity" EXACT [EC:6.6.1.1] xref: EC:6.6.1.1 xref: GO:0016851 is_a: CCO:F0008029 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes [Term] id: CCO:F0003415 name: sirohydrochlorin cobaltochelatase activity namespace: molecular_function def: "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [EC:4.99.1.3] subset: gosubset_prok synonym: "anaerobic cobalt chelatase activity" EXACT [] synonym: "CbiK" NARROW [] synonym: "CbiX" RELATED [EC:4.99.1.3] synonym: "CbiXS" RELATED [EC:4.99.1.3] synonym: "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.3] synonym: "sirohydrochlorin cobalt-lyase activity" EXACT [EC:4.99.1.3] xref: EC:4.99.1.3 xref: GO:0016852 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0003416 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term. subset: goslim_candida subset: goslim_goa subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "other isomerase activity" NARROW [] xref: EC:5 xref: GO:0016853 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0003417 name: racemase and epimerase activity namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that enzymes of class EC:5.1.99.- should also be annotated to this term. Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound. subset: gosubset_prok synonym: "racemase and epimerase activity, acting on other compounds" NARROW [] xref: EC:5.1 xref: GO:0016854 is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0003418 name: racemase and epimerase activity, acting on amino acids and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah] subset: gosubset_prok xref: EC:5.1.1 xref: GO:0016855 is_a: CCO:F0003417 ! racemase and epimerase activity [Term] id: CCO:F0003419 name: racemase and epimerase activity, acting on hydroxy acids and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.1.2 xref: GO:0016856 is_a: CCO:F0003417 ! racemase and epimerase activity [Term] id: CCO:F0003420 name: racemase and epimerase activity, acting on carbohydrates and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.1.3 xref: GO:0016857 is_a: CCO:F0003417 ! racemase and epimerase activity [Term] id: CCO:F0003421 name: cis-trans isomerase activity namespace: molecular_function def: "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:5.2 xref: GO:0016859 is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0003422 name: intramolecular oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-] comment: Note that enzymes of class EC:5.3.99.- should also be annotated to this term. subset: gosubset_prok synonym: "intramolecular isomerase activity" EXACT [] synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW [] xref: EC:5.3 xref: GO:0016860 xref: Reactome:1429 is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0003423 name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses namespace: molecular_function subset: gosubset_prok synonym: "intramolecular isomerase activity, interconverting aldoses and ketoses" EXACT [] xref: EC:5.3.1 xref: GO:0016861 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0003424 name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups namespace: molecular_function subset: gosubset_prok synonym: "intramolecular isomerase activity, interconverting keto- and enol-groups" EXACT [] xref: EC:5.3.2 xref: GO:0016862 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0003425 name: intramolecular oxidoreductase activity, transposing C=C bonds namespace: molecular_function subset: gosubset_prok synonym: "intramolecular isomerase activity, transposing C=C bonds" EXACT [] xref: EC:5.3.3 xref: GO:0016863 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0003426 name: intramolecular oxidoreductase activity, transposing S-S bonds namespace: molecular_function subset: gosubset_prok synonym: "intramolecular isomerase activity, transposing S-S bonds" EXACT [] xref: EC:5.3.4 xref: GO:0016864 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0003427 name: intramolecular transferase activity namespace: molecular_function def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah] comment: Note that enzymes of class EC:5.4.99.- should also be annotated to this term. subset: gosubset_prok synonym: "intramolecular transferase activity, transferring other groups" NARROW [] synonym: "mutase activity" EXACT [] xref: EC:5.4 xref: GO:0016866 is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0003428 name: intramolecular transferase activity, transferring acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.4.1 xref: GO:0016867 is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0003429 name: intramolecular transferase activity, phosphotransferases namespace: molecular_function def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok synonym: "phosphomutase activity" EXACT [] xref: EC:5.4.2 xref: GO:0016868 is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0003430 name: intramolecular transferase activity, transferring amino groups namespace: molecular_function def: "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.4.3 xref: GO:0016869 is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0003431 name: cycloartenol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol." [EC:5.4.99.8] subset: gosubset_prok synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)" EXACT [EC:5.4.99.8] synonym: "2,3-epoxysqualene cycloartenol-cyclase activity" EXACT [EC:5.4.99.8] synonym: "2,3-epoxysqualene--cycloartenol cyclase activity" EXACT [EC:5.4.99.8] synonym: "2,3-oxidosqualene-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] synonym: "oxidosqualene:cycloartenol cyclase activity" EXACT [PMID:18033581] synonym: "squalene-2,3-epoxide-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] xref: EC:5.4.99.8 xref: GO:0016871 xref: MetaCyc:CYCLOARTENOL-SYNTHASE-RXN is_a: CCO:F0004686 ! oxidosqualene cyclase activity [Term] id: CCO:F0003432 name: intramolecular lyase activity namespace: molecular_function def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/] subset: gosubset_prok xref: EC:5.5 xref: GO:0016872 is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0003433 name: ligase activity namespace: molecular_function def: "Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_goa subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: EC:6 xref: GO:0016874 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0003434 name: ligase activity, forming carbon-oxygen bonds namespace: molecular_function def: "Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok xref: EC:6.1 xref: GO:0016875 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0003435 name: ligase activity, forming aminoacyl-tRNA and related compounds namespace: molecular_function def: "Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound." [GOC:jl] subset: gosubset_prok xref: EC:6.1.1 xref: GO:0016876 is_a: CCO:F0003434 ! ligase activity, forming carbon-oxygen bonds [Term] id: CCO:F0003436 name: ligase activity, forming carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] xref: EC:6.2 xref: GO:0016877 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0003437 name: acid-thiol ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid and a thiol via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok xref: EC:6.2.1 xref: GO:0016878 is_a: CCO:F0003436 ! ligase activity, forming carbon-sulfur bonds [Term] id: CCO:F0003438 name: ligase activity, forming carbon-nitrogen bonds namespace: molecular_function def: "Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] comment: Note that enzymes of class EC:6.3.4.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-nitrogen ligase activity" NARROW [] xref: EC:6.3 xref: GO:0016879 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0003439 name: acid-ammonia (or amide) ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok synonym: "amide synthase activity" EXACT [] xref: EC:6.3.1 xref: GO:0016880 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0003440 name: acid-amino acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok synonym: "peptide synthase activity" EXACT [] xref: EC:6.3.2 xref: GO:0016881 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0003441 name: cyclo-ligase activity namespace: molecular_function def: "Catalysis of the ligation of two substances via a carbon-nitrogen bond to form a heterocyclic product, with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:mah] subset: gosubset_prok xref: EC:6.3.3 xref: GO:0016882 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0003442 name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor namespace: molecular_function def: "Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532] subset: gosubset_prok xref: EC:6.3.5 xref: GO:0016003 xref: GO:0016884 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0003443 name: ligase activity, forming carbon-carbon bonds namespace: molecular_function def: "Catalysis of the ligation of two substances via a carbon-carbon bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok xref: EC:6.4 xref: GO:0016885 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0003444 name: ligase activity, forming phosphoric ester bonds namespace: molecular_function def: "Catalysis of the ligation of two substances via a phosphoric ester bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok xref: EC:6.5 xref: GO:0016886 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0003445 name: ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "(Ca2+ + Mg2+)-ATPase" NARROW [EC:3.6.1.3] synonym: "adenosine 5'-triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosine triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosinetriphosphatase activity" EXACT [] synonym: "ATP hydrolase activity" EXACT [EC:3.6.1.3] synonym: "ATP monophosphatase activity" EXACT [EC:3.6.1.3] synonym: "ATP phosphohydrolase activity" EXACT [] synonym: "complex V (mitochondrial electron transport)" RELATED [EC:3.6.1.3] synonym: "HCO3--ATPase" NARROW [EC:3.6.1.3] synonym: "SV40 T-antigen" RELATED [EC:3.6.1.3] xref: GO:0004002 xref: GO:0016887 is_a: CCO:F0003574 ! nucleoside-triphosphatase activity [Term] id: CCO:F0003446 name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "endodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.21 xref: GO:0016888 is_a: CCO:F0000917 ! endodeoxyribonuclease activity is_a: CCO:F0003451 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: CCO:F0003447 name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] xref: EC:3.1.22 xref: GO:0016889 is_a: CCO:F0000917 ! endodeoxyribonuclease activity is_a: CCO:F0003452 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: CCO:F0003448 name: site-specific endodeoxyribonuclease activity, specific for altered base namespace: molecular_function xref: EC:3.1.25 xref: GO:0016890 is_a: CCO:F0000917 ! endodeoxyribonuclease activity [Term] id: CCO:F0003449 name: endoribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] subset: gosubset_prok xref: EC:3.1.26 xref: GO:0016891 is_a: CCO:F0000918 ! endoribonuclease activity is_a: CCO:F0003451 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: CCO:F0003450 name: endoribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "endoribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] xref: EC:3.1.27 xref: GO:0016892 is_a: CCO:F0000918 ! endoribonuclease activity is_a: CCO:F0003452 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: CCO:F0003451 name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok synonym: "5'-endonuclease activity" EXACT [] synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" RELATED [] xref: EC:3.1.30 xref: GO:0016893 is_a: CCO:F0000916 ! endonuclease activity [Term] id: CCO:F0003452 name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok synonym: "3'-endonuclease activity" EXACT [] synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED [] xref: EC:3.1.31 xref: GO:0016894 is_a: CCO:F0000916 ! endonuclease activity [Term] id: CCO:F0003453 name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.11 xref: GO:0016895 is_a: CCO:F0000925 ! exodeoxyribonuclease activity is_a: CCO:F0003366 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: CCO:F0003454 name: exoribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.13 xref: GO:0016896 is_a: CCO:F0000928 ! exoribonuclease activity is_a: CCO:F0003366 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: CCO:F0003455 name: exoribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai] xref: EC:3.1.14 xref: GO:0016897 is_a: CCO:F0000928 ! exoribonuclease activity is_a: CCO:F0003367 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: CCO:F0003456 name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.1.2 xref: GO:0016898 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003457 name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.1.3 xref: GO:0016899 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003458 name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:ai] synonym: "oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor" EXACT [] xref: EC:1.1.4 xref: GO:0016900 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003459 name: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.1.5 xref: GO:0016901 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003460 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.2.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW [] xref: EC:1.2 xref: GO:0016903 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003461 name: myosin heavy chain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] synonym: "ATP:myosin heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] synonym: "ATP:myosin-heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] synonym: "calmodulin-dependent myosin heavy chain kinase activity" EXACT [EC:2.7.11.7] synonym: "MHCK" RELATED [EC:2.7.11.7] synonym: "MIHC kinase activity" EXACT [EC:2.7.11.7] synonym: "myosin heavy chain kinase A activity" EXACT [EC:2.7.11.7] synonym: "myosin heavy-chain kinase activity" EXACT [EC:2.7.11.7] synonym: "myosin I heavy-chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin-heavy-chain kinase activity" EXACT [EC:2.7.11.7] synonym: "STK6" RELATED [EC:2.7.11.7] xref: EC:2.7.11.7 xref: GO:0016905 xref: MetaCyc:MYOSIN-HEAVY-CHAIN-KINASE-RXN is_a: CCO:F0001053 ! calmodulin-dependent protein kinase activity [Term] id: CCO:F0003462 name: sterol 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173] synonym: "sterol 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "sterol glucosyltransferase activity" EXACT [] synonym: "sterol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "sterol:UDPG glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-sterol beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose:sterol glucosyltransferase activity" EXACT [] synonym: "UDPG-SGTase activity" EXACT [EC:2.4.1.173] synonym: "UDPG:sterol glucosyltransferase activity" EXACT [] synonym: "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "uridine diphosphoglucose-poriferasterol glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "uridine diphosphoglucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] xref: EC:2.4.1.173 xref: GO:0016906 xref: MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0003463 name: G-protein coupled acetylcholine receptor activity namespace: molecular_function synonym: "G protein coupled acetylcholine receptor activity" EXACT [] synonym: "G-protein-coupled acetylcholine receptor activity" EXACT [] xref: GO:0016907 is_a: CCO:F0001782 ! amine receptor activity is_a: CCO:F0002870 ! acetylcholine receptor activity [Term] id: CCO:F0003464 name: MAP kinase 2 activity namespace: molecular_function synonym: "ERK2" EXACT [] xref: EC:2.7.11.- xref: GO:0016908 is_a: CCO:F0001073 ! MAP kinase activity [Term] id: CCO:F0003465 name: SAP kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines." [GOC:ma] synonym: "SAPK" EXACT [] synonym: "stress-activated kinase activity" EXACT [] synonym: "stress-activated protein kinase activity" EXACT [] xref: EC:2.7.11.- xref: GO:0016909 is_a: CCO:F0001073 ! MAP kinase activity [Term] id: CCO:F0003466 name: follicle-stimulating hormone activity namespace: molecular_function def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland." [ISBN:0198547684] xref: GO:0016913 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0003467 name: GABA receptor activity namespace: molecular_function def: "Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity." [GOC:jl, http://cancerweb.ncl.ac.uk/] comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'. synonym: "4-aminobutanoate receptor activity" EXACT [] synonym: "4-aminobutyrate receptor activity" EXACT [] synonym: "GABA binding" EXACT [] synonym: "gamma-aminobutyrate binding" EXACT [] synonym: "gamma-aminobutyric acid binding" EXACT [] synonym: "gamma-aminobutyric acid receptor activity" EXACT [] xref: GO:0016917 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0003468 name: retinal binding namespace: molecular_function def: "Interacting selectively with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "blue-sensitive opsin" RELATED [] synonym: "green-sensitive opsin" RELATED [] synonym: "long-wave-sensitive opsin" RELATED [] synonym: "opsin" RELATED [] synonym: "red-sensitive opsin" RELATED [] synonym: "retinaldehyde binding" EXACT [] synonym: "short-wave-sensitive opsin" RELATED [] synonym: "UV-sensitive opsin" RELATED [] synonym: "violet-sensitive opsin" RELATED [] synonym: "vitamin A binding" BROAD [] xref: GO:0016918 is_a: CCO:F0001639 ! retinoid binding is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0003469 name: nardilysin activity namespace: molecular_function def: "Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [EC:3.4.24.61] synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61] synonym: "NRD convertase activity" EXACT [EC:3.4.24.61] synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61] xref: EC:3.4.24.61 xref: GO:0016919 xref: MetaCyc:3.4.24.61-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0003470 name: pyroglutamyl-peptidase activity namespace: molecular_function subset: gosubset_prok xref: EC:3.4.19.- xref: GO:0016920 is_a: CCO:F0001792 ! omega peptidase activity [Term] id: CCO:F0003471 name: pyroglutamyl-peptidase II activity namespace: molecular_function def: "Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6] synonym: "PAP-II activity" EXACT [EC:3.4.19.6] synonym: "pyroglutamate aminopeptidase II" RELATED [EC:3.4.19.6] synonym: "pyroglutamyl aminopeptidase II activity" EXACT [EC:3.4.19.6] synonym: "pyroglutamyl peptidase II" RELATED [EC:3.4.19.6] synonym: "thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "thyroliberinase activity" NARROW [EC:3.4.19.6] synonym: "thyrotropin-releasing factor pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone degrading ectoenzyme activity" NARROW [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone-degrading peptidase activity" EXACT [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "TRH-DE activity" NARROW [EC:3.4.19.6] synonym: "TRH-degrading ectoenzyme activity" NARROW [EC:3.4.19.6] synonym: "TRH-specific aminopeptidase activity" NARROW [EC:3.4.19.6] xref: EC:3.4.19.6 xref: GO:0016921 xref: MetaCyc:3.4.19.6-RXN is_a: CCO:F0001787 ! metallopeptidase activity is_a: CCO:F0003470 ! pyroglutamyl-peptidase activity [Term] id: CCO:F0003472 name: ligand-dependent nuclear receptor binding namespace: molecular_function def: "Interacting selectively, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974] synonym: "ligand-dependent nuclear receptor interactor activity" RELATED [] xref: GO:0016922 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0003473 name: SUMO-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250] synonym: "SUSP" NARROW [] synonym: "ULP" NARROW [] xref: GO:0016929 is_a: CCO:F0004166 ! small conjugating protein-specific protease activity [Term] id: CCO:F0003474 name: vasopressin activated calcium mobilizing receptor activity namespace: molecular_function xref: GO:0016931 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0003475 name: extracellular-glycine-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "glycine receptor" BROAD [] xref: GO:0016933 is_a: CCO:F0001506 ! excitatory extracellular ligand-gated ion channel activity [Term] id: CCO:F0003476 name: extracellular-glycine-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "glycine receptor" BROAD [] xref: GO:0016934 is_a: CCO:F0001522 ! chloride channel activity is_a: CCO:F0003475 ! extracellular-glycine-gated ion channel activity [Term] id: CCO:F0003477 name: galactoside binding namespace: molecular_function def: "Interacting selectively with any glycoside in which the sugar moiety is galactose." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0016936 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0003478 name: short-branched-chain-acyl-CoA dehydrogenase activity namespace: molecular_function xref: EC:1.3.99.- xref: GO:0016937 is_a: CCO:F0000480 ! acyl-CoA dehydrogenase activity [Term] id: CCO:F0003479 name: natriuretic peptide receptor activity namespace: molecular_function xref: GO:0016941 is_a: CCO:F0000195 ! peptide receptor activity [Term] id: CCO:F0003480 name: RNA polymerase I transcription elongation factor activity namespace: molecular_function def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah] synonym: "Pol I transcription elongation factor activity" EXACT [] xref: GO:0016943 is_a: CCO:F0000298 ! transcription elongation regulator activity [Term] id: CCO:F0003481 name: RNA polymerase II transcription elongation factor activity namespace: molecular_function def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah] synonym: "Pol II transcription elongation factor activity" EXACT [] xref: GO:0016944 is_a: CCO:F0000298 ! transcription elongation regulator activity [Term] id: CCO:F0003482 name: RNA polymerase III transcription elongation factor activity namespace: molecular_function def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah] synonym: "Pol III transcription elongation factor activity" EXACT [] xref: GO:0016945 is_a: CCO:F0000298 ! transcription elongation regulator activity [Term] id: CCO:F0003483 name: cathepsin F activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41] xref: EC:3.4.22.41 xref: GO:0016946 xref: MetaCyc:3.4.22.41-RXN is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0003484 name: class I ribonucleotide reductase activity namespace: molecular_function synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" EXACT [] xref: GO:0016959 xref: Reactome:4419 is_a: CCO:F0001113 ! ribonucleoside-diphosphate reductase activity [Term] id: CCO:F0003485 name: class II ribonucleotide reductase activity namespace: molecular_function synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" EXACT [] synonym: "class II ribonucleoside-diphosphate reductase activity" EXACT [] xref: GO:0016960 is_a: CCO:F0001113 ! ribonucleoside-diphosphate reductase activity [Term] id: CCO:F0003486 name: class III ribonucleotide reductase activity namespace: molecular_function synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" EXACT [] xref: GO:0016961 is_a: CCO:F0001113 ! ribonucleoside-diphosphate reductase activity [Term] id: CCO:F0003487 name: alpha-2 macroglobulin receptor activity namespace: molecular_function def: "Combining with an alpha-2 macroglobulin to initiate a change in cell activity." [GOC:ma] xref: GO:0016964 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0003488 name: nitric oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrous oxide + acceptor + H2O = 2 nitric oxide + reduced acceptor." [EC:1.7.99.7, MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN] subset: gosubset_prok synonym: "CYP55" NARROW [] synonym: "cytochrome bc nitric oxide reductase activity" NARROW [] synonym: "nitric-oxide reductase activity" EXACT [EC:1.7.99.7] synonym: "nitrogen oxide reductase activity" EXACT [EC:1.7.99.7] synonym: "nitrous-oxide:(acceptor) oxidoreductase (NO-forming)" EXACT [EC:1.7.99.7] synonym: "nitrous-oxide:acceptor oxidoreductase (NO-forming)" EXACT [EC:1.7.99.7] synonym: "P450 nitric oxide reductase activity" NARROW [] synonym: "P450nor" NARROW [] xref: EC:1.7.99.7 xref: GO:0016966 xref: GO:0016967 xref: GO:0016968 xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN is_a: CCO:F0003256 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: CCO:F0003489 name: flavin-linked sulfhydryl oxidase activity namespace: molecular_function def: "Catalysis of the formation of disulfide bridges." [PMID:10899311] xref: GO:0016971 is_a: CCO:F0003490 ! thiol oxidase activity [Term] id: CCO:F0003490 name: thiol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2] synonym: "sulfhydryl oxidase activity" EXACT [EC:1.8.3.2] synonym: "thiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.2] xref: EC:1.8.3.2 xref: GO:0016972 xref: MetaCyc:THIOL-OXIDASE-RXN is_a: CCO:F0003263 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor [Term] id: CCO:F0003491 name: sodium channel auxiliary protein activity namespace: molecular_function xref: GO:0016974 is_a: CCO:F0002865 ! auxiliary transport protein activity [Term] id: CCO:F0003493 name: chitosanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132] subset: gosubset_prok synonym: "chitosan N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.132] xref: EC:3.2.1.132 xref: GO:0016977 xref: MetaCyc:3.2.1.132-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003494 name: lipoate-protein ligase activity namespace: molecular_function def: "Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein." [EC:6.3.4.-] subset: gosubset_prok synonym: "lipoate-protein ligase A activity" NARROW [] synonym: "lipoate-protein ligase B activity" NARROW [] xref: EC:6.3.4.- xref: GO:0008916 xref: GO:0016978 xref: GO:0016979 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0003495 name: creatinase activity namespace: molecular_function def: "Catalysis of the reaction: creatine + H2O = sarcosine + urea." [EC:3.5.3.3] subset: gosubset_prok synonym: "creatine amidinohydrolase activity" EXACT [EC:3.5.3.3] xref: EC:3.5.3.3 xref: GO:0016980 xref: MetaCyc:CREATINASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0003496 name: cytokine beta-glucosidase activity namespace: molecular_function xref: GO:0016983 is_a: CCO:F0001889 ! beta-glucosidase activity [Term] id: CCO:F0003497 name: ribulose-bisphosphate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate." [EC:4.1.1.39] subset: gosubset_prok synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.39] synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming)" EXACT [EC:4.1.1.39] synonym: "carboxydismutase activity" RELATED [EC:4.1.1.39] synonym: "D-ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "D-ribulose-1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "diphosphoribulose carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-bisphosphate carboxylase/oxygenase activity" EXACT [] synonym: "ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "ribulose bisphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "ribulose diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "rubisco activity" EXACT [] synonym: "RuBisCO activity" EXACT [EC:4.1.1.39] synonym: "RuBP carboxylase activity" EXACT [EC:4.1.1.39] xref: EC:4.1.1.39 xref: GO:0016984 xref: MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003498 name: mannan endo-1,4-beta-mannosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,4-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78] subset: gosubset_prok synonym: "1,4-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "beta-1, 4-mannan 4-mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "beta-D-mannanase activity" EXACT [EC:3.2.1.78] synonym: "beta-mannanase activity" EXACT [EC:3.2.1.78] synonym: "beta-mannanase B" RELATED [EC:3.2.1.78] synonym: "endo-1,4-beta-mannanase activity" EXACT [EC:3.2.1.78] synonym: "endo-1,4-mannanase activity" EXACT [EC:3.2.1.78] synonym: "endo-beta-1,4-mannase activity" EXACT [EC:3.2.1.78] synonym: "endo-beta-mannanase activity" EXACT [EC:3.2.1.78] xref: EC:3.2.1.78 xref: GO:0016985 xref: MetaCyc:3.2.1.78-RXN is_a: CCO:F0000951 ! beta-mannosidase activity [Term] id: CCO:F0003499 name: transcription initiation factor activity namespace: molecular_function subset: gosubset_prok synonym: "transcriptional initiation factor activity" EXACT [] xref: GO:0016986 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0003500 name: sigma factor activity namespace: molecular_function def: "A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes." [GOC:krc] subset: gosubset_prok synonym: "sigma transcription factor" RELATED [] xref: GO:0016987 is_a: CCO:F0003499 ! transcription initiation factor activity [Term] id: CCO:F0003501 name: transcription initiation factor antagonist activity namespace: molecular_function def: "The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl] subset: gosubset_prok synonym: "transcriptional initiation factor antagonist activity" EXACT [] xref: GO:0016988 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0003502 name: sigma factor antagonist activity namespace: molecular_function def: "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, http://en.wikipedia.org/wiki/Anti-sigma_factors] subset: gosubset_prok synonym: "anti-sigma factor activity" EXACT [] xref: GO:0016989 is_a: CCO:F0003501 ! transcription initiation factor antagonist activity [Term] id: CCO:F0003503 name: arginine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3." [EC:3.5.3.6] subset: gosubset_prok synonym: "arginine dihydrolase activity" EXACT [EC:3.5.3.6] synonym: "citrulline iminase activity" EXACT [EC:3.5.3.6] synonym: "L-arginine deiminase activity" EXACT [EC:3.5.3.6] synonym: "L-arginine iminohydrolase activity" EXACT [EC:3.5.3.6] xref: EC:3.5.3.6 xref: GO:0016990 xref: MetaCyc:ARGININE-DEIMINASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0003504 name: lipoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8] subset: gosubset_prok synonym: "LipA" RELATED [EC:2.8.1.8] synonym: "lipoyl synthase activity" EXACT [EC:2.8.1.8] synonym: "LS" RELATED [EC:2.8.1.8] synonym: "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] xref: EC:2.8.1.8 xref: GO:0016992 is_a: CCO:F0003355 ! sulfurtransferase activity is_a: CCO:F0003494 ! lipoate-protein ligase activity [Term] id: CCO:F0003505 name: precorrin-8X methylmutase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate." [EC:5.4.1.2] subset: gosubset_prok synonym: "HBA synthase activity" EXACT [EC:5.4.1.2] synonym: "hydrogenobyrinic acid-binding protein activity" NARROW [EC:5.4.1.2] synonym: "precorrin isomerase activity" EXACT [EC:5.4.1.2] synonym: "precorrin-8X 11,12-methylmutase activity" EXACT [EC:5.4.1.2] xref: EC:5.4.1.2 xref: GO:0016993 xref: MetaCyc:5.4.1.2-RXN is_a: CCO:F0003428 ! intramolecular transferase activity, transferring acyl groups [Term] id: CCO:F0003506 name: precorrin-6A reductase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+." [EC:1.3.1.54] subset: gosubset_prok synonym: "precorrin-6B:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] synonym: "precorrin-6X reductase activity" EXACT [] synonym: "precorrin-6Y:NADP(+) oxidoreductase activity" EXACT [EC:1.3.1.54] synonym: "precorrin-6Y:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] xref: EC:1.3.1.54 xref: GO:0016994 xref: MetaCyc:1.3.1.54-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003507 name: cholesterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + O2 = cholest-4-en-3-one + H2O2." [EC:1.1.3.6] synonym: "3beta-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "3beta-hydroxysteroid:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol- O2 oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol-O(2) oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol-O2 oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] xref: EC:1.1.3.6 xref: GO:0016995 xref: MetaCyc:CHOLESTEROL-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0003508 name: endo-alpha-sialidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129] synonym: "alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] synonym: "endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endo-N-acylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endoneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endosialidase activity" EXACT [EC:3.2.1.129] synonym: "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] synonym: "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "polysialoside (2->8)-alpha-sialosylhydrolase activity" EXACT [EC:3.2.1.129] xref: EC:3.2.1.129 xref: GO:0016996 xref: MetaCyc:3.2.1.129-RXN is_a: CCO:F0003509 ! alpha-sialidase activity [Term] id: CCO:F0003509 name: alpha-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah] subset: gosubset_prok xref: GO:0016997 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0003510 name: activin receptor activity namespace: molecular_function def: "Combining with activin, one of two gonadal glycoproteins related to transforming growth factor beta, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0017002 is_a: CCO:F0001354 ! transforming growth factor beta receptor activity [Term] id: CCO:F0003511 name: tyrosyl-DNA phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354] comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. xref: GO:0017005 is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0003512 name: Ras GTPase binding namespace: molecular_function def: "Interacting selectively with any member of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Ras interactor activity" RELATED [] xref: GO:0017016 is_a: CCO:F0004648 ! small GTPase binding [Term] id: CCO:F0003513 name: MAP kinase tyrosine/serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] synonym: "dual-specificity MAP kinase phosphatase activity" EXACT [] xref: EC:3.1.3.- xref: GO:0017017 is_a: CCO:F0001741 ! protein tyrosine/serine/threonine phosphatase activity is_a: CCO:F0005176 ! MAP kinase phosphatase activity [Term] id: CCO:F0003514 name: myosin phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] synonym: "myosin phosphatase myosin binding" RELATED [] synonym: "myosin phosphatase, intrinsic catalyst activity" EXACT [] xref: GO:0017018 xref: GO:0017019 is_a: CCO:F0001087 ! protein serine/threonine phosphatase activity [Term] id: CCO:F0003515 name: myosin phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme myosin phosphatase." [EC:3.1.3.16, GOC:ai] synonym: "myosin phosphatase, intrinsic regulator activity" NARROW [] xref: GO:0017020 is_a: CCO:F0004205 ! protein phosphatase regulator activity [Term] id: CCO:F0003516 name: myosin binding namespace: molecular_function def: "Interacting selectively with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] synonym: "myosin phosphatase myosin binding" NARROW [] xref: GO:0017022 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0003517 name: myosin I binding namespace: molecular_function def: "Interacting selectively with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0017024 is_a: CCO:F0003516 ! myosin binding [Term] id: CCO:F0003518 name: TATA-binding protein binding namespace: molecular_function def: "Interacting selectively with TATA-binding protein (TBP), a component of various transcription factors." [GOC:jl, http://www.mblab.gla.ac.uk/] synonym: "TBP binding" EXACT [] xref: GO:0017025 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0003519 name: procollagen C-endopeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [EC:3.4.24.19] synonym: "BMP1" NARROW [] synonym: "carboxyprocollagen peptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-terminal peptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19] xref: EC:3.4.24.19 xref: GO:0017026 xref: MetaCyc:3.4.24.19-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0003520 name: potassium:amino acid symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai] synonym: "potassium:amino acid transporter activity" BROAD [] xref: GO:0017032 is_a: CCO:F0001608 ! cation:amino acid symporter activity [Term] id: CCO:F0003521 name: DNA topoisomerase I binding namespace: molecular_function def: "Interacting selectively with the enzyme DNA topoisomerase I." [GOC:ai] xref: GO:0017033 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0003522 name: Rap guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: GO:0017034 is_a: CCO:F0001393 ! Ras guanyl-nucleotide exchange factor activity [Term] id: CCO:F0003523 name: dipeptidyl-peptidase III activity namespace: molecular_function def: "Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4] subset: gosubset_prok synonym: "dipeptidyl aminopeptidase III activity" EXACT [EC:3.4.14.4] synonym: "dipeptidyl arylamidase III activity" EXACT [EC:3.4.14.4] synonym: "DPP III activity" EXACT [EC:3.4.14.4] synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4] synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4] xref: EC:3.4.14.4 xref: GO:0017039 xref: MetaCyc:3.4.14.4-RXN is_a: CCO:F0001789 ! dipeptidyl-peptidase activity [Term] id: CCO:F0003524 name: ceramidase activity namespace: molecular_function def: "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23] subset: gosubset_prok synonym: "acylsphingosine deacylase activity" EXACT [EC:3.5.1.23] synonym: "glycosphingolipid ceramide deacylase" BROAD [EC:3.5.1.23] synonym: "N-acylsphingosine amidohydrolase activity" EXACT [EC:3.5.1.23] xref: EC:3.5.1.23 xref: GO:0017040 xref: MetaCyc:CERAMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0003525 name: galactosylgalactosylglucosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47] synonym: "ceramide trihexosidase activity" EXACT [EC:3.2.1.47] synonym: "ceramidetrihexosidase activity" EXACT [EC:3.2.1.47] synonym: "ceramidetrihexoside alpha-galactosidase activity" EXACT [EC:3.2.1.47] synonym: "D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.47] synonym: "trihexosyl ceramide galactosidase activity" EXACT [EC:3.2.1.47] synonym: "trihexosylceramide alpha-galactosidase activity" EXACT [EC:3.2.1.47] xref: EC:3.2.1.47 xref: GO:0017041 xref: MetaCyc:3.2.1.47-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: CCO:F0003524 ! ceramidase activity [Term] id: CCO:F0003526 name: glycosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [EC:3.2.1.62] synonym: "cerebrosidase activity" EXACT [EC:3.2.1.62] synonym: "glycosyl ceramide glycosylhydrolase activity" EXACT [EC:3.2.1.62] synonym: "glycosyl-N-acylsphingosine glycohydrolase activity" EXACT [EC:3.2.1.62] synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.2.1.62] synonym: "phloretin-glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phloridzin beta-glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phloridzin glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phlorizin hydrolase activity" EXACT [EC:3.2.1.62] xref: EC:3.2.1.62 xref: GO:0017042 xref: MetaCyc:GLYCOSYLCERAMIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: CCO:F0003524 ! ceramidase activity [Term] id: CCO:F0003527 name: alpha-melanocyte stimulating hormone activity namespace: molecular_function synonym: "alpha-melanophore stimulating hormone activity" EXACT [] xref: GO:0017044 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0003528 name: adrenocorticotropin-releasing hormone activity namespace: molecular_function synonym: "corticotropin-releasing hormone" EXACT [] xref: GO:0017045 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0003529 name: peptide hormone binding namespace: molecular_function def: "Interacting selectively with any peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "polypeptide hormone binding" EXACT [] xref: GO:0017046 is_a: CCO:F0005639 ! peptide binding is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0003530 name: adrenocorticotropin-releasing hormone binding namespace: molecular_function def: "Interacting selectively with adrenocorticotropin-releasing hormone." [GOC:jl] xref: GO:0017047 is_a: CCO:F0003529 ! peptide hormone binding [Term] id: CCO:F0003531 name: Rho GTPase binding namespace: molecular_function def: "Interacting selectively with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856] synonym: "Rho interactor activity" RELATED [] synonym: "Rhophilin" NARROW [] xref: GO:0017031 xref: GO:0017048 is_a: CCO:F0003512 ! Ras GTPase binding [Term] id: CCO:F0003532 name: GTP-Rho binding namespace: molecular_function def: "Interacting selectively with the GTP-bound form of the Rho protein." [GOC:mah] xref: GO:0017049 is_a: CCO:F0003531 ! Rho GTPase binding [Term] id: CCO:F0003533 name: D-erythro-sphingosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [UniProtKB:Q9JIA7] synonym: "sphingosine kinase activity" EXACT [] xref: GO:0017050 is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0003534 name: retinol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081] xref: GO:0017051 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003535 name: structural constituent of nuclear pore namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [GOC:mah] xref: GO:0017056 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0003536 name: 6-phosphogluconolactonase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate." [EC:3.1.1.31] subset: gosubset_prok synonym: "6-PGL" RELATED [EC:3.1.1.31] synonym: "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.31] synonym: "phosphogluconolactonase activity" EXACT [EC:3.1.1.31] xref: EC:3.1.1.31 xref: GO:0017057 xref: MetaCyc:6PGLUCONOLACT-RXN xref: Reactome:25159 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0003537 name: FH1 domain binding namespace: molecular_function def: "Interacting selectively with a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators] xref: GO:0017058 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0003538 name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65] synonym: "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "(Lea)-dependent (alpha-3/4)-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "alpha(1,3/1,4) fucosyltransferase III" RELATED [EC:2.4.1.65] synonym: "alpha(1,4)-L-fucosyltransferase activity" EXACT [] synonym: "alpha-(1,3/1,4) fucosyltransferase III activity" EXACT [EC:2.4.1.65] synonym: "alpha-(1->4)-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "alpha-4-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "beta-acetylglucosaminylsaccharide fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "blood group Lewis alpha-4-fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "blood group Lewis alpha-4-fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "blood-group substance Le(a)-dependent fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "blood-group substance Lea-dependent fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "FucT-II activity" EXACT [EC:2.4.1.65] synonym: "galactoside 3(4)-L-fucosyltransferase activity" EXACT [] synonym: "GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "Lewis alpha-(1->3/4)-fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "Lewis alpha-(1->3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "Lewis FT activity" NARROW [EC:2.4.1.65] synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity" NARROW [EC:2.4.1.65] xref: EC:2.4.1.65 xref: GO:0017060 xref: MetaCyc:2.4.1.65-RXN is_a: CCO:F0001884 ! fucosyltransferase activity [Term] id: CCO:F0003539 name: S-methyl-5-thioadenosine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28] subset: gosubset_prok synonym: "5'-deoxy-5'-methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "5'-methylthioadenosine phosphorylase activity" EXACT [] synonym: "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] synonym: "MeSAdo phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MeSAdo/Ado phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "methylthioadenosine nucleoside phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MTA phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MTAPase activity" EXACT [EC:2.4.2.28] synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] xref: EC:2.4.2.28 xref: GO:0017061 xref: MetaCyc:5 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0003540 name: phosphatidylserine-specific phospholipase A1 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.32] xref: GO:0017063 is_a: CCO:F0002303 ! phospholipase A1 activity [Term] id: CCO:F0003541 name: fatty acid amide hydrolase activity namespace: molecular_function xref: GO:0017064 xref: GO:0017073 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0003542 name: single-strand selective uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623] synonym: "single-strand selective monofunctional uracil-DNA glycosylase activity" EXACT [] xref: EC:3.2.2.- xref: GO:0017065 xref: Reactome:25182 is_a: CCO:F0001200 ! uracil DNA N-glycosylase activity [Term] id: CCO:F0003543 name: tyrosine-ester sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate." [EC:2.8.2.9] synonym: "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity" EXACT [EC:2.8.2.9] synonym: "aryl sulfotransferase IV" RELATED [EC:2.8.2.9] synonym: "L-tyrosine methyl ester sulfotransferase activity" EXACT [EC:2.8.2.9] synonym: "tyrosine-ester sulphotransferase activity" EXACT [] xref: EC:2.8.2.9 xref: GO:0008128 xref: GO:0017067 xref: MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0003544 name: snRNA binding namespace: molecular_function def: "Interacting selectively with a small nuclear RNA (snRNA)." [GOC:mah] synonym: "small nuclear RNA binding" EXACT [] xref: GO:0017069 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0003545 name: U6 snRNA binding namespace: molecular_function def: "Interacting selectively with the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). xref: GO:0017070 is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0003546 name: procollagen N-endopeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [EC:3.4.24.14] synonym: "aminoprocollagen peptidase activity" EXACT [EC:3.4.24.14] synonym: "aminoterminal procollagen peptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen aminopeptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen aminoterminal protease activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-proteinase activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14] synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14] synonym: "type III procollagen" RELATED [EC:3.4.24.14] xref: EC:3.4.24.14 xref: GO:0017074 xref: MetaCyc:3.4.24.14-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0003547 name: syntaxin-1 binding namespace: molecular_function def: "Interacting selectively with the SNAP receptor syntaxin-1." [GOC:ai] xref: GO:0017075 is_a: CCO:F0004214 ! syntaxin binding [Term] id: CCO:F0003548 name: purine nucleotide binding namespace: molecular_function def: "Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] subset: gosubset_prok xref: GO:0017076 is_a: CCO:F0000031 ! nucleotide binding [Term] id: CCO:F0003549 name: oxidative phosphorylation uncoupler activity namespace: molecular_function def: "Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945] synonym: "mitochondrial uncoupling protein activity" NARROW [] synonym: "uncoupling protein activity" NARROW [] xref: GO:0015302 xref: GO:0017077 is_a: CCO:F0004284 ! transmembrane transporter activity [Term] id: CCO:F0003550 name: Hsc70 protein regulator activity namespace: molecular_function def: "Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403] synonym: "Hsc70 interacting protein" BROAD [] xref: GO:0017078 is_a: CCO:F0004345 ! Hsp70/Hsc70 protein regulator activity is_a: CCO:F0004456 ! Hsp70 protein binding [Term] id: CCO:F0003551 name: sodium channel regulator activity namespace: molecular_function xref: GO:0017080 is_a: CCO:F0003086 ! channel regulator activity [Term] id: CCO:F0003552 name: chloride channel regulator activity namespace: molecular_function xref: GO:0017081 is_a: CCO:F0003086 ! channel regulator activity [Term] id: CCO:F0003553 name: mineralocorticoid receptor activity namespace: molecular_function def: "Combining with mineralocorticoid to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. xref: GO:0017082 is_a: CCO:F0000295 ! steroid hormone receptor activity [Term] id: CCO:F0003554 name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152] synonym: "galactoside 3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "galactoside 3-L-fucosyltransferase activity" EXACT [] synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "lewis-negative alpha-3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "Lewis-negative alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] synonym: "plasma alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] xref: EC:2.4.1.152 xref: GO:0017083 xref: MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN is_a: CCO:F0006272 ! alpha(1,3)-fucosyltransferase activity [Term] id: CCO:F0003555 name: delta1-pyrroline-5-carboxylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI] synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT [] xref: GO:0017084 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003556 name: X-Pro dipeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11] subset: gosubset_prok synonym: "PepX" RELATED [EC:3.4.14.11] synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11] synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11] synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT [] xref: EC:3.4.14.11 xref: GO:0017088 xref: MetaCyc:3.4.14.11-RXN is_a: CCO:F0001789 ! dipeptidyl-peptidase activity [Term] id: CCO:F0003557 name: glycolipid transporter activity namespace: molecular_function def: "Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells." [GOC:ai] xref: GO:0017089 is_a: CCO:F0001556 ! lipid transporter activity [Term] id: CCO:F0003558 name: AU-rich element binding namespace: molecular_function def: "Interacting selectively with AU-rich elements within the 3' untranslated region of mRNAs." [GOC:mah, PMID:7892223] synonym: "ARE binding" EXACT [] synonym: "AU-specific RNA binding" EXACT [] xref: GO:0017091 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0003559 name: sterol regulatory element-binding protein site 2 protease activity namespace: molecular_function def: "Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525] synonym: "SREBP site 2 protease activity" EXACT [] xref: GO:0017092 is_a: CCO:F0001787 ! metallopeptidase activity is_a: CCO:F0003560 ! sterol regulatory element-binding protein protease activity [Term] id: CCO:F0003560 name: sterol regulatory element-binding protein protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] synonym: "SREBP protease activity" EXACT [] xref: GO:0017093 is_a: CCO:F0001783 ! peptidase activity [Term] id: CCO:F0003561 name: sterol regulatory element-binding protein site 1 protease activity namespace: molecular_function def: "Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525] synonym: "SREBP site 1 protease activity" EXACT [] xref: GO:0017094 is_a: CCO:F0001786 ! serine-type peptidase activity is_a: CCO:F0003560 ! sterol regulatory element-binding protein protease activity [Term] id: CCO:F0003562 name: heparan sulfate 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808] synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0017095 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0003563 name: acetylserotonin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin (N-acetyl-5-methoxytryptamine)." [EC:2.1.1.4] subset: gosubset_prok synonym: "acetylserotonin methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "hydroxyindole methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "hydroxyindole O-methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] xref: EC:2.1.1.4 xref: GO:0017096 xref: MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003564 name: acetylserotonin N-methyltransferase activity namespace: molecular_function xref: GO:0017097 is_a: CCO:F0001757 ! N-methyltransferase activity [Term] id: CCO:F0003565 name: sulfonylurea receptor binding namespace: molecular_function def: "Interacting selectively with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023] synonym: "sulfonylurea receptor ligand" NARROW [] synonym: "sulphonylurea receptor binding" EXACT [] xref: GO:0017098 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0003566 name: very-long-chain-acyl-CoA dehydrogenase activity namespace: molecular_function xref: EC:1.3.99.- xref: GO:0017099 is_a: CCO:F0000480 ! acyl-CoA dehydrogenase activity [Term] id: CCO:F0003567 name: aminoacyl-tRNA synthetase auxiliary protein activity namespace: molecular_function xref: GO:0017100 is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0003568 name: UTP:galactose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose." [EC:2.7.7.10] synonym: "alpha-D-galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.10] synonym: "galactose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.10] synonym: "galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.10] synonym: "UDPgalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "uridine diphosphate galactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "uridine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "UTP-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "UTP:hexose-1-phosphate uridylyltransferase activity" BROAD [] xref: EC:2.7.7.10 xref: GO:0003982 xref: GO:0017103 xref: MetaCyc:UTPHEXPURIDYLYLTRANS-RXN is_a: CCO:F0008184 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: CCO:F0003569 name: acyl-CoA delta11-desaturase activity namespace: molecular_function synonym: "acyl-CoA D11-desaturase activity" EXACT [] synonym: "acyl-CoA delta(11)-desaturase activity" EXACT [] xref: GO:0017105 is_a: CCO:F0003074 ! CoA desaturase activity [Term] id: CCO:F0003570 name: activin inhibitor activity namespace: molecular_function def: "Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: GO:0017106 is_a: CCO:F0001225 ! signal transducer activity [Term] id: CCO:F0003571 name: anion exchanger adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT] xref: GO:0017107 is_a: CCO:F0002805 ! anion exchanger activity is_a: CCO:F0008241 ! molecular adaptor activity [Term] id: CCO:F0003572 name: 5'-flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254, UniProtKB:P39749] synonym: "5' flap endonuclease activity" EXACT [] xref: GO:0017108 xref: Reactome:25632 is_a: CCO:F0003446 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters is_a: CCO:F0007325 ! flap endonuclease activity [Term] id: CCO:F0003573 name: nucleoside-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6] synonym: "apyrase activity" BROAD [] synonym: "CDPase" NARROW [EC:3.6.1.6] synonym: "IDPase" NARROW [EC:3.6.1.6] synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6] synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6] synonym: "NDPase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphatase activity" EXACT [] synonym: "nucleoside diphosphate phosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6] synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6] xref: EC:3.6.1.6 xref: GO:0017110 xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0003574 name: nucleoside-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] subset: gosubset_prok synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" EXACT [] synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] xref: EC:3.6.1.15 xref: GO:0017111 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0003575 name: Rab guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: GO:0017112 is_a: CCO:F0001393 ! Ras guanyl-nucleotide exchange factor activity [Term] id: CCO:F0003576 name: dihydropyrimidine dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2] subset: gosubset_prok synonym: "4,5-dihydrothymine: oxidoreductase activity" EXACT [EC:1.3.1.2] synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.2] synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.2] synonym: "DHPDH" RELATED [EC:1.3.1.2] synonym: "DHU dehydrogenase activity" EXACT [EC:1.3.1.2] synonym: "dihydropyrimidine dehydrogenase activity" EXACT [] synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2] synonym: "dihydrouracil dehydrogenase (NADP)" EXACT [EC:1.3.1.2] synonym: "dihydrouracil dehydrogenase (NADP+) activity" EXACT [EC:1.3.1.2] synonym: "DPD" RELATED [EC:1.3.1.2] synonym: "hydropyrimidine dehydrogenase activity" EXACT [EC:1.3.1.2] xref: EC:1.3.1.2 xref: GO:0017113 xref: MetaCyc:1.3.1.2-RXN xref: Reactome:25636 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003577 name: wide-spectrum protease inhibitor activity namespace: molecular_function synonym: "wide-spectrum proteinase inhibitor" EXACT [] xref: GO:0017114 is_a: CCO:F0001222 ! endopeptidase inhibitor activity [Term] id: CCO:F0003578 name: single-stranded DNA-dependent ATP-dependent DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. xref: GO:0017116 is_a: CCO:F0000487 ! ATP-dependent DNA helicase activity is_a: CCO:F0005804 ! single-stranded DNA-dependent ATPase activity [Term] id: CCO:F0003579 name: lipoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme." [PMID:10103005] subset: gosubset_prok xref: GO:0017118 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0003580 name: polyphosphoinositide phosphatase activity namespace: molecular_function def: "Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048] xref: GO:0017120 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0003581 name: Ral GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Ral family." [GOC:mah] xref: GO:0017123 is_a: CCO:F0001404 ! Ras GTPase activator activity [Term] id: CCO:F0003582 name: SH3 domain binding namespace: molecular_function def: "Interacting selectively with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018] xref: GO:0017124 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0003583 name: deoxycytidyl transferase activity namespace: molecular_function def: "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901] synonym: "deoxycytidyl transferase activity, template-dependent" NARROW [] xref: GO:0017125 xref: GO:0019986 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0003584 name: cholesterol transporter activity namespace: molecular_function def: "Enables the directed movement of cholesterol into, out of, within or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] xref: GO:0017127 is_a: CCO:F0002716 ! sterol transporter activity [Term] id: CCO:F0003585 name: phospholipid scramblase activity namespace: molecular_function xref: GO:0017128 is_a: CCO:F0001671 ! phospholipid transporter activity [Term] id: CCO:F0003586 name: triglyceride binding namespace: molecular_function def: "Interacting selectively with any triester of glycerol." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0017129 is_a: CCO:F0001816 ! lipid binding [Term] id: CCO:F0003587 name: poly(rC) binding namespace: molecular_function def: "Interacting selectively with a sequence of cytosine residues in an RNA molecule." [GOC:mah] xref: GO:0017130 is_a: CCO:F0000312 ! single-stranded RNA binding [Term] id: CCO:F0003588 name: uridine-rich cytoplasmic polyadenylylation element binding namespace: molecular_function def: "Interacting selectively with U-rich sequence in the 3'-end of mRNAs; required for cytoplasmic polyadenylylation." [PMID:7954828] synonym: "uridine-rich cytoplasmic polyadenylation element binding" EXACT [] xref: GO:0017131 is_a: CCO:F0001768 ! poly-pyrimidine tract binding [Term] id: CCO:F0003589 name: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by a GTPase; dependent on the presence of a cyclic nucleotide." [GOC:mah, PMID:9856955] xref: GO:0017132 is_a: CCO:F0001390 ! guanyl-nucleotide exchange factor activity [Term] id: CCO:F0003590 name: fibroblast growth factor binding namespace: molecular_function def: "Interacting selectively with fibroblast growth factor." [PMID:9806903] synonym: "FGF binding" EXACT [] xref: GO:0017134 is_a: CCO:F0004188 ! growth factor binding [Term] id: CCO:F0003591 name: NAD-dependent histone deacetylase activity namespace: molecular_function def: "Catalysis of the removal of acetyl groups from histones, requiring NAD." [GOC:ai] synonym: "SIR2" RELATED [] xref: GO:0017136 is_a: CCO:F0000816 ! histone deacetylase activity [Term] id: CCO:F0003592 name: Rab GTPase binding namespace: molecular_function def: "Interacting selectively with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Rab escort protein activity" NARROW [] synonym: "Rab interactor activity" RELATED [] synonym: "REP" NARROW [] xref: GO:0005084 xref: GO:0017137 is_a: CCO:F0001388 ! small GTPase regulator activity is_a: CCO:F0003512 ! Ras GTPase binding [Term] id: CCO:F0003593 name: lipoic acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: octanoic acid + 2 S = lipoic acid + 2 H." [PMID:11106496, PMID:11389890] subset: gosubset_prok xref: GO:0017140 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0003594 name: Wnt-protein binding namespace: molecular_function def: "Interacting selectively with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] xref: GO:0017147 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0003595 name: tRNA dihydrouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710] subset: gosubset_prok xref: GO:0017150 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003596 name: DEAD/H-box RNA helicase binding namespace: molecular_function def: "Interacting selectively with the enzyme DEAD/H-box RNA helicase." [GOC:jl] xref: GO:0017151 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0003597 name: sodium:dicarboxylate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "sodium:dicarboxylate cotransporter activity" EXACT [] xref: GO:0017153 is_a: CCO:F0001551 ! dicarboxylic acid transmembrane transporter activity is_a: CCO:F0001571 ! organic acid:sodium symporter activity is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0003598 name: semaphorin receptor activity namespace: molecular_function xref: GO:0017154 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0003599 name: pantetheine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol." [EC:3.5.1.92] synonym: "(R)-pantetheine amidohydrolase activity" EXACT [EC:3.5.1.92] synonym: "pantetheinase activity" EXACT [EC:3.5.1.92] synonym: "vanin" RELATED [EC:3.5.1.92] synonym: "vanin-1" RELATED [EC:3.5.1.92] xref: EC:3.5.1.92 xref: GO:0017159 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0003600 name: Ral GTPase binding namespace: molecular_function def: "Interacting selectively with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Ral interactor activity" RELATED [] xref: GO:0017160 is_a: CCO:F0003512 ! Ras GTPase binding [Term] id: CCO:F0003601 name: inositol-1,3,4-trisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3.- xref: GO:0017161 is_a: CCO:F0006172 ! inositol trisphosphate phosphatase activity [Term] id: CCO:F0003602 name: aryl hydrocarbon receptor binding namespace: molecular_function def: "Interacting selectively with an aryl hydrocarbon receptor." [GOC:ai] xref: GO:0017162 is_a: CCO:F0001407 ! receptor binding is_a: CCO:F0001738 ! transcription factor binding [Term] id: CCO:F0003603 name: negative regulator of basal transcription activity namespace: molecular_function subset: gosubset_prok xref: GO:0017163 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0003604 name: dipeptidase E activity namespace: molecular_function def: "Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21] subset: gosubset_prok synonym: "alpha-aspartyl dipeptidase activity" EXACT [] synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21] synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21] synonym: "peptidase E activity" BROAD [EC:3.4.13.21] xref: EC:3.4.13.21 xref: GO:0017165 xref: MetaCyc:3.4.13.21-RXN is_a: CCO:F0003375 ! dipeptidase activity [Term] id: CCO:F0003605 name: vinculin binding namespace: molecular_function def: "Interacting selectively with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: GO:0017166 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0003606 name: 5-oxoprolinase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate." [EC:3.5.2.9] subset: gosubset_prok synonym: "5-OPase activity" EXACT [EC:3.5.2.9] synonym: "5-oxo-L-prolinase activity" EXACT [EC:3.5.2.9] synonym: "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "5-oxoprolinase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "5-oxoprolinase activity" EXACT [EC:3.5.2.9] synonym: "L-pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] synonym: "oxoprolinase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "pyroglutamase (ATP-hydrolyzing) activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamic hydrolase activity" EXACT [EC:3.5.2.9] xref: EC:3.5.2.9 xref: GO:0017168 xref: MetaCyc:5-OXOPROLINASE-(ATP-HYDROLYSING)-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0003607 name: CDP-alcohol phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai] subset: gosubset_prok xref: GO:0017169 is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0003608 name: KU70 binding namespace: molecular_function def: "Interacting selectively with Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985] xref: GO:0017170 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0003609 name: serine hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://en.wikipedia.org/wiki/Serine_hydrolase] xref: GO:0017171 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0003610 name: cysteine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + O2 = 3-sulfinoalanine." [EC:1.13.11.20] subset: gosubset_prok xref: EC:1.13.11.20 xref: GO:0017172 xref: MetaCyc:CYSTEINE-DIOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003611 name: DRAP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate." [GOC:jl, MetaCyc:YOL066C-MONOMER] xref: GO:0017173 is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0003612 name: glycine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20] synonym: "glycine methyltransferase activity" EXACT [EC:2.1.1.20] synonym: "GNMT" RELATED [EC:2.1.1.20] synonym: "S-adenosyl-L-methionine:glycine methyltransferase activity" EXACT [EC:2.1.1.20] synonym: "S-adenosyl-L-methionine:glycine N-methyltransferase activity" EXACT [EC:2.1.1.20] xref: EC:2.1.1.20 xref: GO:0017174 xref: MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003613 name: phosphatidylinositol N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198] synonym: "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity" EXACT [EC:2.4.1.198] synonym: "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] synonym: "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] synonym: "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] xref: EC:2.4.1.198 xref: GO:0017176 xref: MetaCyc:2.4.1.198-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0003614 name: diphthine-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphthine + NH3 = ADP + phosphate + diphthamide." [EC:6.3.2.22] synonym: "diphthamide synthase activity" EXACT [EC:6.3.2.22] synonym: "diphthamide synthetase activity" EXACT [EC:6.3.2.22] synonym: "diphthine:ammonia ligase (ADP-forming)" EXACT [EC:6.3.2.22] xref: EC:6.3.2.22 xref: GO:0017178 xref: MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN is_a: CCO:F0003071 ! ammonia ligase activity [Term] id: CCO:F0003615 name: aspartate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-aspartate = CoA + N-acetyl-L-aspartate." [EC:2.3.1.17] synonym: "acetyl-CoA:L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] synonym: "aspartate acetyltransferase activity" EXACT [EC:2.3.1.17] synonym: "L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] xref: EC:2.3.1.17 xref: GO:0017188 xref: MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0003616 name: glycoprotein N-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96] synonym: "mucus glycoprotein fatty acyltransferase" NARROW [EC:2.3.1.96] synonym: "palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity" EXACT [EC:2.3.1.96] xref: EC:2.3.1.96 xref: GO:0018010 xref: MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN is_a: CCO:F0004052 ! N-palmitoyltransferase activity [Term] id: CCO:F0003617 name: histone-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "protein (lysine) methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "protein methylase 3 activity" NARROW [EC:2.1.1.43] synonym: "protein methylase III activity" NARROW [EC:2.1.1.43] synonym: "protein methyltransferase II activity" NARROW [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.43] xref: EC:2.1.1.43 xref: GO:0018024 xref: MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN xref: RESID:AA0074 xref: RESID:AA0075 xref: RESID:AA0076 is_a: CCO:F0003100 ! protein-lysine N-methyltransferase activity is_a: CCO:F0005616 ! histone methyltransferase activity [Term] id: CCO:F0003618 name: calmodulin-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60] synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.60] synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.60] synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" EXACT [EC:2.1.1.60] xref: EC:2.1.1.60 xref: GO:0018025 xref: MetaCyc:2.1.1.60-RXN is_a: CCO:F0003100 ! protein-lysine N-methyltransferase activity [Term] id: CCO:F0003619 name: peptidyl-lysine N6-myristoyltransferase activity namespace: molecular_function xref: EC:2.3.1.- xref: GO:0018030 is_a: CCO:F0000797 ! glycylpeptide N-tetradecanoyltransferase activity [Term] id: CCO:F0003620 name: peptidyl-lysine N6-palmitoyltransferase activity namespace: molecular_function xref: EC:2.3.1.- xref: GO:0018031 is_a: CCO:F0004052 ! N-palmitoyltransferase activity [Term] id: CCO:F0003621 name: protein-histidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine." [EC:2.1.1.85] synonym: "actin-specific histidine methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "peptidyl-histidine N-methyltransferase activity" EXACT [] synonym: "protein (histidine) methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "protein methylase IV activity" NARROW [EC:2.1.1.85] synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" EXACT [EC:2.1.1.85] xref: EC:2.1.1.85 xref: GO:0018064 xref: MetaCyc:2.1.1.85-RXN is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003622 name: NAD(P)-cysteine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [EC:2.4.2.-] xref: EC:2.4.2.- xref: GO:0018071 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0003623 name: histone arginine kinase activity namespace: molecular_function synonym: "histone-arginine kinase activity" EXACT [] xref: EC:2.7.3.- xref: GO:0018110 is_a: CCO:F0000529 ! arginine kinase activity is_a: CCO:F0005564 ! histone kinase activity [Term] id: CCO:F0003624 name: methionine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine = D-methionine." [EC:5.1.1.2] xref: EC:5.1.1.2 xref: GO:0018111 xref: MetaCyc:METHIONINE-RACEMASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0003625 name: proline racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline = D-proline." [EC:5.1.1.4] subset: gosubset_prok xref: EC:5.1.1.4 xref: GO:0018112 xref: MetaCyc:PROLINE-RACEMASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0003626 name: lysine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine = D-lysine." [EC:5.1.1.5] xref: EC:5.1.1.5 xref: GO:0018113 xref: MetaCyc:LYSINE-RACEMASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0003627 name: threonine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = D-threonine." [EC:5.1.1.6] xref: EC:5.1.1.6 xref: GO:0018114 xref: MetaCyc:THREONINE-RACEMASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0003628 name: NAD(P)-asparagine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [EC:2.4.2.-] xref: EC:2.4.2.- xref: GO:0018121 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0003629 name: NAD(P)-serine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [EC:2.4.2.-] xref: EC:2.4.2.- xref: GO:0018127 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0003630 name: peptidyl-serine cyclase activity namespace: molecular_function xref: EC:4.2.1.- xref: GO:0018128 is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003631 name: peptidyl-oxazoline dehydrogenase activity namespace: molecular_function xref: EC:1.3.-.- xref: GO:0018129 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003632 name: peptidyl-cysteine cyclase activity namespace: molecular_function xref: EC:4.2.1.- xref: GO:0018135 is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003633 name: peptidyl-thiazoline dehydrogenase activity namespace: molecular_function xref: EC:1.3.-.- xref: GO:0018136 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003634 name: ribosomal S6-glutamic acid ligase activity namespace: molecular_function xref: EC:6.3.2.- xref: GO:0018169 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0003635 name: ribulose-bisphosphate carboxylase activase activity namespace: molecular_function xref: EC:6.3.-.- xref: GO:0018236 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0003636 name: urease activase activity namespace: molecular_function xref: EC:6.3.-.- xref: GO:0018237 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0003637 name: biotin-protein ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah] subset: gosubset_prok synonym: "biotin-apoprotein ligase activity" EXACT [] xref: EC:6.3.4.- xref: GO:0000106 xref: GO:0018271 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0003638 name: protein-serine epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5.1.1.16] synonym: "protein-serine racemase activity" EXACT [EC:5.1.1.16] xref: EC:5.1.1.16 xref: GO:0018365 xref: MetaCyc:5.1.1.16-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0003639 name: glycoprotein 3-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosaminyl}asparagine." [EC:2.4.1.214] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity" EXACT [] synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] xref: EC:2.4.1.214 xref: GO:0018392 xref: MetaCyc:2.4.1.214-RXN is_a: CCO:F0006272 ! alpha(1,3)-fucosyltransferase activity [Term] id: CCO:F0003640 name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity namespace: molecular_function xref: EC:2.7.8.- xref: GO:0018421 is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0003641 name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity namespace: molecular_function xref: EC:2.7.8.- xref: GO:0018422 is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0003642 name: protein-leucine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester; this reaction is the methylation of peptidyl-L-leucine to form peptidyl-L-leucine methyl ester." [PMID:8514774] synonym: "protein phosphatase methyltransferase activity" NARROW [] xref: EC:2.1.1.- xref: GO:0018423 is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0001813 ! protein methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003643 name: prothoracicotrophic hormone activity namespace: molecular_function xref: GO:0018445 is_a: CCO:F0001481 ! neuropeptide hormone activity [Term] id: CCO:F0003644 name: pinocarveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-." [UM-BBD_enzymeID:e0449] xref: EC:1.1.-.- xref: GO:0018446 xref: UM-BBD_enzymeID:e0449 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003645 name: chloral hydrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: chloral hydrate = 3 H+ + 2 e- + trichloroacetate OR chloral hydrate + H2 = H2O + trichloroethanol." [UM-BBD_enzymeID:e0229] xref: EC:1.1.-.- xref: GO:0018447 xref: UM-BBD_enzymeID:e0229 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003646 name: hydroxymethylmethylsilanediol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [UM-BBD_enzymeID:e0326] xref: EC:1.1.-.- xref: GO:0018448 xref: UM-BBD_enzymeID:e0326 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003647 name: 1-phenylethanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2." [UM-BBD_enzymeID:e0210] xref: EC:1.1.-.- xref: GO:0018449 xref: UM-BBD_enzymeID:e0210 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003648 name: myrtenol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [UM-BBD_enzymeID:e0444] xref: EC:1.1.-.- xref: GO:0018450 xref: UM-BBD_enzymeID:e0444 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003649 name: epoxide dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: ethene oxide (ethylene oxide) + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [UM-BBD_enzymeID:e0398] xref: EC:1.1.1.- xref: GO:0018451 xref: UM-BBD_enzymeID:e0398 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003650 name: 5-exo-hydroxycamphor dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_enzymeID:e0301] xref: EC:1.1.1.- xref: GO:0018452 xref: UM-BBD_enzymeID:e0301 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003651 name: 2-hydroxytetrahydrofuran dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [UM-BBD_enzymeID:e0016] xref: EC:1.1.1.- xref: GO:0018453 xref: UM-BBD_enzymeID:e0016 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003652 name: acetoacetyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36] subset: gosubset_prok synonym: "(R)-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.36] synonym: "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.36] synonym: "acetoacetyl coenzyme A reductase activity" EXACT [EC:1.1.1.36] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.36] synonym: "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity" EXACT [EC:1.1.1.36] synonym: "D-3-hydroxyacyl-CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "hydroxyacyl coenzyme-A dehydrogenase activity" EXACT [EC:1.1.1.36] synonym: "NADP-linked acetoacetyl CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "NADPH:acetoacetyl-CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity" EXACT [EC:1.1.1.36] xref: EC:1.1.1.36 xref: GO:0018454 xref: MetaCyc:ACETOACETYL-COA-REDUCTASE-RXN xref: UM-BBD_enzymeID:e0005 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003653 name: alcohol dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+." [EC:1.1.1.71] synonym: "alcohol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.71] synonym: "aldehyde reductase (NADPH/NADH)" EXACT [EC:1.1.1.71] synonym: "retinal reductase activity" NARROW [EC:1.1.1.71] xref: EC:1.1.1.71 xref: GO:0018455 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-(NAD(P)+)-RXN xref: UM-BBD_enzymeID:e0169 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003654 name: aryl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90] subset: gosubset_prok synonym: "aryl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.90] synonym: "benzyl alcohol dehydrogenase activity" NARROW [] synonym: "coniferyl alcohol dehydrogenase" BROAD [EC:1.1.1.90] synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90] xref: EC:1.1.1.90 xref: GO:0018456 xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0019 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003655 name: perillyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: perillyl alcohol + NAD+ = perillyl aldehyde + NADH + H+." [EC:1.1.1.144] synonym: "perillyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.144] synonym: "perillyl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.144] xref: EC:1.1.1.144 xref: GO:0018457 xref: MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0459 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003656 name: isopiperitenol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-trans-isopiperitenol + NAD+ = (-)-isopiperitenone + NADH + H+." [EC:1.1.1.223] synonym: "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.223] xref: EC:1.1.1.223 xref: GO:0018458 xref: MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0468 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003657 name: carveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-trans-carveol + NADP+ = (-)-carvone + NADPH + H+." [EC:1.1.1.243] synonym: "(-)-trans-carveol dehydrogenase activity" EXACT [EC:1.1.1.243] synonym: "(-)-trans-carveol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.243] xref: EC:1.1.1.243 xref: GO:0018459 xref: MetaCyc:CARVEOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0446 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003658 name: cyclohexanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+." [EC:1.1.1.245] synonym: "cyclohexanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.245] xref: EC:1.1.1.245 xref: GO:0018460 xref: MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0165 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003659 name: fluoren-9-ol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256] synonym: "9-fluorenol dehydrogenase activity" EXACT [] synonym: "fluoren-9-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.256] xref: EC:1.1.1.256 xref: GO:0018461 xref: MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0292 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003660 name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + NADH + H+." [EC:1.1.1.257] synonym: "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.257] synonym: "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity" EXACT [] synonym: "4-sulfobenzyl alcohol dehydrogenase activity" EXACT [] xref: EC:1.1.1.257 xref: GO:0018462 xref: MetaCyc:1.1.1.257-RXN xref: UM-BBD_enzymeID:e0239 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003661 name: 6-hydroxyhexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH + H+." [EC:1.1.1.258] synonym: "6-hydroxyhexanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.258] xref: EC:1.1.1.258 xref: GO:0018463 xref: MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN xref: UM-BBD_enzymeID:e0168 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003662 name: 3-hydroxypimeloyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypimeloyl-CoA + NAD+ = 3-oxopimeloyl-CoA + NADH + H+." [EC:1.1.1.259] synonym: "3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.259] xref: EC:1.1.1.259 xref: GO:0018464 xref: MetaCyc:1.1.1.259-RXN xref: UM-BBD_enzymeID:e0181 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003663 name: vanillyl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: vanillyl alcohol + O2 = vanillin + H2O2." [EC:1.1.3.38] synonym: "4-hydroxy-2-methoxybenzyl alcohol oxidase activity" EXACT [EC:1.1.3.38] synonym: "vanillyl alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.38] xref: EC:1.1.3.38 xref: GO:0018465 xref: MetaCyc:1.1.3.38-RXN xref: UM-BBD_enzymeID:e0404 is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0003664 name: limonene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_enzymeID:e0463] xref: EC:1.1.99.- xref: GO:0018466 xref: UM-BBD_enzymeID:e0463 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003665 name: formaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: formaldehyde + NAD+ + H2O = formate + NADH + H+. This enzyme does not need reduced glutathione." [EC:1.2.1.46] subset: gosubset_prok synonym: "formaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.46] synonym: "glutathione-independent formaldehyde dehydrogenase activity" EXACT [] xref: EC:1.2.1.46 xref: GO:0018467 xref: MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0120 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003666 name: alcohol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor." [EC:1.1.99.8] subset: gosubset_prok synonym: "alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.8] synonym: "alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.8] synonym: "MDH" RELATED [EC:1.1.99.8] synonym: "PQQ-dependent alcohol dehydrogenase activity" EXACT [] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.99.8] synonym: "quinohemoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] synonym: "quinoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] synonym: "quinoprotein ethanol dehydrogenase activity" EXACT [EC:1.1.99.8] xref: EC:1.1.99.8 xref: GO:0018468 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-(ACCEPTOR)-RXN xref: UM-BBD_enzymeID:e0004 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0003667 name: myrtenal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [UM-BBD_enzymeID:e0448] xref: EC:1.2.-.- xref: GO:0018469 xref: UM-BBD_enzymeID:e0448 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0003668 name: 4-hydroxybutaraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [UM-BBD_enzymeID:e0018] xref: EC:1.2.-.- xref: GO:0018470 xref: UM-BBD_enzymeID:e0018 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0003669 name: 4-chlorobenzaldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_enzymeID:e0316] xref: EC:1.14.13.- xref: GO:0018471 xref: UM-BBD_enzymeID:e0316 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003670 name: 1-hydroxy-2-naphthaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [UM-BBD_enzymeID:e0328] xref: EC:1.2.1.- xref: GO:0018472 xref: UM-BBD_enzymeID:e0328 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003671 name: cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_enzymeID:e0472] xref: EC:1.2.1.- xref: GO:0018473 xref: UM-BBD_enzymeID:e0472 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003672 name: 2-carboxybenzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate." [UM-BBD_enzymeID:e0331] xref: EC:1.2.1.- xref: GO:0018474 xref: UM-BBD_enzymeID:e0331 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003673 name: trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_enzymeID:e0474] xref: EC:1.2.1.- xref: GO:0018475 xref: UM-BBD_enzymeID:e0474 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003674 name: benzaldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+." [EC:1.2.1.7] synonym: "benzaldehyde:NADP+ oxidoreductase" EXACT [EC:1.2.1.7] synonym: "NADP-linked benzaldehyde dehydrogenase" EXACT [EC:1.2.1.7] xref: EC:1.2.1.7 xref: GO:0018477 xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-(NADP+)-RXN xref: UM-BBD_enzymeID:e0079 is_a: CCO:F0004061 ! benzaldehyde dehydrogenase activity [Term] id: CCO:F0003675 name: malonate-semialdehyde dehydrogenase (acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+." [EC:1.2.1.18] subset: gosubset_prok synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)" EXACT [EC:1.2.1.18] synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT [] xref: EC:1.2.1.18 xref: GO:0018478 xref: MetaCyc:1.2.1.18-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003676 name: benzaldehyde dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+." [EC:1.2.1.28] subset: gosubset_prok synonym: "benzaldehyde (NAD) dehydrogenase activity" EXACT [EC:1.2.1.28] synonym: "benzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.28] xref: EC:1.2.1.28 xref: GO:0018479 xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-(NAD+)-RXN xref: UM-BBD_enzymeID:e0101 is_a: CCO:F0004061 ! benzaldehyde dehydrogenase activity [Term] id: CCO:F0003677 name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60] subset: gosubset_prok synonym: "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.60] synonym: "carboxymethylhydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.60] xref: EC:1.2.1.60 xref: GO:0018480 xref: MetaCyc:CHMS-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0280 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003678 name: 4-hydroxymuconic-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxymuconic semialdehyde + NAD+ + H2O = maleylacetate + NADH + H+." [EC:1.2.1.61] subset: gosubset_prok synonym: "4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.61] xref: EC:1.2.1.61 xref: GO:0018481 xref: MetaCyc:1.2.1.61-RXN xref: UM-BBD_enzymeID:e0204 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003679 name: 4-formylbenzenesulfonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-formylbenzenesulfonate + NAD+ + H2O = 4-sulfobenzoate + NADH + H+." [EC:1.2.1.62] synonym: "4-formylbenzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.62] synonym: "4-formylbenzenesulphonate dehydrogenase activity" EXACT [] synonym: "toluene-sulfonate aldehyde dehydrogenase activity" EXACT [] xref: EC:1.2.1.62 xref: GO:0018482 xref: MetaCyc:1.2.1.62-RXN xref: UM-BBD_enzymeID:e0240 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003680 name: 6-oxohexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+." [EC:1.2.1.63] synonym: "6-oxohexanoate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.63] xref: EC:1.2.1.63 xref: GO:0018483 xref: MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN xref: UM-BBD_enzymeID:e0171 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003681 name: 4-hydroxybenzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64] synonym: "3-hydroxybenzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.64] synonym: "p-hydroxybenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.64] xref: EC:1.2.1.64 xref: GO:0018484 xref: MetaCyc:1.2.1.64-RXN xref: UM-BBD_enzymeID:e0226 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003682 name: salicylaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+." [EC:1.2.1.65] subset: gosubset_prok synonym: "salicylaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.65] xref: EC:1.2.1.65 xref: GO:0018485 xref: MetaCyc:1.2.1.65-RXN xref: UM-BBD_enzymeID:e0256 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003683 name: 2-butanone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [UM-BBD_enzymeID:e0053] xref: EC:1.2.3.- xref: GO:0018486 xref: UM-BBD_enzymeID:e0053 is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0003684 name: vanillate O-demethylase (anaerobic) activity namespace: molecular_function def: "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [UM-BBD_enzymeID:e0480] xref: EC:1.2.3.- xref: GO:0018487 xref: UM-BBD_enzymeID:e0480 is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor is_a: CCO:F0004997 ! demethylase activity [Term] id: CCO:F0003685 name: aryl-aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + H2O2." [EC:1.2.3.9] synonym: "aryl-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.9] xref: EC:1.2.3.9 xref: GO:0018488 xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN xref: UM-BBD_enzymeID:e0116 is_a: CCO:F0000509 ! aldehyde oxidase activity [Term] id: CCO:F0003686 name: vanillate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: vanillate + O2 + NADH + H+ = 3,4-dihydroxybenzoate + NAD+ + H2O + formaldehyde." [EC:1.14.13.82] comment: Note that this was EC:1.2.3.12. subset: gosubset_prok synonym: "4-hydroxy-3-methoxybenzoate demethylase activity" EXACT [EC:1.14.13.82] synonym: "vanillate demethylase (aerobic) activity" EXACT [] synonym: "vanillate demethylase activity" EXACT [] synonym: "vanillate:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.13.82] xref: EC:1.14.13.82 xref: GO:0018489 xref: MetaCyc:RXN-2 xref: UM-BBD_enzymeID:e0117 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen is_a: CCO:F0004997 ! demethylase activity [Term] id: CCO:F0003687 name: 4-hydroxyphenylpyruvate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + 1/2 O2 = 4-hydroxyphenylacetate + CO2." [EC:1.2.3.13] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.2.3.13] xref: EC:1.2.3.13 xref: GO:0018490 xref: MetaCyc:1.2.3.13-RXN xref: UM-BBD_enzymeID:e0244 is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0003688 name: 2-oxobutyrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.2] synonym: "2-ketobutyrate synthase activity" EXACT [EC:1.2.7.2] synonym: "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)" EXACT [EC:1.2.7.2] synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2] synonym: "alpha-ketobutyrate synthase activity" EXACT [EC:1.2.7.2] synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2] xref: EC:1.2.7.2 xref: GO:0018491 xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN xref: UM-BBD_enzymeID:e0275 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003689 name: carbon-monoxide dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2] subset: gosubset_prok synonym: "anaerobic carbon monoxide dehydrogenase activity" EXACT [EC:1.2.99.2] synonym: "carbon monoxide dehydrogenase activity" BROAD [] synonym: "carbon-monoxide:acceptor oxidoreductase activity" EXACT [EC:1.2.99.2] xref: EC:1.2.99.2 xref: GO:0018492 xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0415 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0003690 name: formylmethanofuran dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor." [EC:1.2.99.5] subset: gosubset_prok synonym: "formylmethanofuran:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.5] synonym: "formylmethanofuran:acceptor oxidoreductase activity" EXACT [EC:1.2.99.5] xref: EC:1.2.99.5 xref: GO:0018493 xref: MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0121 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0003691 name: carvone reductase activity namespace: molecular_function def: "Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone." [UM-BBD_enzymeID:e0473] xref: EC:1.3.-.- xref: GO:0018494 xref: UM-BBD_enzymeID:e0473 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003692 name: 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [UM-BBD_enzymeID:e0177] xref: EC:1.3.-.- xref: GO:0018495 xref: UM-BBD_enzymeID:e0177 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003693 name: 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_enzymeID:e0186] xref: EC:1.3.-.- xref: GO:0018496 xref: UM-BBD_enzymeID:e0186 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003694 name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [UM-BBD_enzymeID:e0352] synonym: "DDMS dehydrogenase activity" EXACT [] xref: EC:1.3.-.- xref: GO:0018497 xref: UM-BBD_enzymeID:e0352 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003695 name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308] xref: EC:1.3.1.- xref: GO:0018498 xref: UM-BBD_enzymeID:e0308 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003696 name: cis-2,3-dihydrodiol DDT dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [UM-BBD_enzymeID:e0320] xref: EC:1.3.1.- xref: GO:0018499 xref: UM-BBD_enzymeID:e0320 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003697 name: trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [UM-BBD_enzymeID:e0381] xref: EC:1.3.1.- xref: GO:0018500 xref: UM-BBD_enzymeID:e0381 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003698 name: cis-chlorobenzene dihydrodiol dehydrogenase activity namespace: molecular_function xref: EC:1.3.1.- xref: GO:0018501 xref: UM-BBD_enzymeID:e0411 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003699 name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_enzymeID:e0362] xref: EC:1.3.1.- xref: GO:0018502 xref: UM-BBD_enzymeID:e0362 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003700 name: trans-1,2-dihydrodiolphenanthrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [UM-BBD_enzymeID:e0380] xref: EC:1.3.1.- xref: GO:0018503 xref: UM-BBD_enzymeID:e0380 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003701 name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19] subset: gosubset_prok synonym: "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.19] synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity" EXACT [EC:1.3.1.19] synonym: "cis-benzene glycol dehydrogenase activity" EXACT [EC:1.3.1.19] xref: EC:1.3.1.19 xref: GO:0018504 xref: MetaCyc:1.3.1.19-RXN xref: UM-BBD_enzymeID:e0060 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003702 name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29] synonym: "(+)-cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity" EXACT [] synonym: "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.29] synonym: "cis-dihydrodiol naphthalene dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] xref: EC:1.3.1.29 xref: GO:0018505 xref: MetaCyc:1.3.1.29-RXN xref: UM-BBD_enzymeID:e0122 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003703 name: maleylacetate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+." [EC:1.3.1.32] subset: gosubset_prok synonym: "3-oxoadipate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.32] synonym: "maleolylacetate reductase activity" EXACT [EC:1.3.1.32] xref: EC:1.3.1.32 xref: GO:0018506 xref: MetaCyc:MALEYLACETATE-REDUCTASE-RXN xref: UM-BBD_enzymeID:e0063 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003704 name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD+ = phenanthrene-3,4-diol + NADH + H+." [EC:1.3.1.49] synonym: "(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity" EXACT [EC:1.3.1.49] synonym: "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity" EXACT [] xref: EC:1.3.1.49 xref: GO:0018507 xref: MetaCyc:1.3.1.49-RXN xref: UM-BBD_enzymeID:e0322 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003705 name: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "benzoate cis-diol dehydrogenase activity" EXACT [] xref: GO:0018508 xref: MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0219 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003706 name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56] subset: gosubset_prok synonym: "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity" EXACT [] synonym: "biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity" EXACT [EC:1.3.1.56] synonym: "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.56] xref: EC:1.3.1.56 xref: GO:0018509 xref: MetaCyc:1.3.1.56-RXN xref: UM-BBD_enzymeID:e0134 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003707 name: phloroglucinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrophloroglucinol + NADP+ = phloroglucinol + NADPH + H+." [EC:1.3.1.57] subset: gosubset_prok synonym: "dihydrophloroglucinol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.57] xref: EC:1.3.1.57 xref: GO:0018510 xref: MetaCyc:R5-RXN xref: UM-BBD_enzymeID:e0010 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003708 name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ = 2,3-dihydroxy-p-cumate + NADH + H+." [EC:1.3.1.58] subset: gosubset_prok synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.58] xref: EC:1.3.1.58 xref: GO:0018511 xref: MetaCyc:RXN-665 xref: UM-BBD_enzymeID:e0284 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003709 name: dibenzothiophene dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + NADH + H+." [EC:1.3.1.60] subset: gosubset_prok synonym: "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.60] xref: EC:1.3.1.60 xref: GO:0018513 xref: MetaCyc:1.3.1.60-RXN xref: UM-BBD_enzymeID:e0161 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003710 name: terephthalate 1,2-cis-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH + H+." [EC:1.3.1.61] synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.61] xref: EC:1.3.1.61 xref: GO:0018514 xref: MetaCyc:1.3.1.61-RXN xref: UM-BBD_enzymeID:e0108 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003711 name: pimeloyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+." [EC:1.3.1.62] subset: gosubset_prok synonym: "pimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.62] xref: EC:1.3.1.62 xref: GO:0018515 xref: MetaCyc:1.3.1.62-RXN xref: UM-BBD_enzymeID:e0179 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003712 name: 2,4-dichlorobenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + NADP+ + HCl = 2,4-dichlorobenzoyl-CoA + NADPH + H+." [EC:1.3.1.63] synonym: "4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)" EXACT [EC:1.3.1.63] xref: EC:1.3.1.63 xref: GO:0018516 xref: MetaCyc:1.3.1.63-RXN xref: UM-BBD_enzymeID:e0111 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003713 name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+." [EC:1.3.1.64] synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.64] xref: EC:1.3.1.64 xref: GO:0018517 xref: MetaCyc:1.3.1.64-RXN xref: UM-BBD_enzymeID:e0105 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003714 name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + NADH + H+." [EC:1.3.1.65] synonym: "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase" RELATED [] synonym: "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.65] xref: EC:1.3.1.65 xref: GO:0018518 xref: MetaCyc:RXN-643 xref: UM-BBD_enzymeID:e0047 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003715 name: cis-dihydroethylcatechol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD+ = 3-ethylcatechol + NADH + H+." [EC:1.3.1.66] synonym: "cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.66] synonym: "cis-ethylbenzene glycol dehydrogenase activity" EXACT [] xref: EC:1.3.1.66 xref: GO:0018519 xref: MetaCyc:1.3.1.66-RXN xref: UM-BBD_enzymeID:e0218 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003716 name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67] synonym: "4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity" EXACT [] synonym: "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.67] xref: EC:1.3.1.67 xref: GO:0018520 xref: MetaCyc:1.3.1.67-RXN xref: UM-BBD_enzymeID:e0173 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003717 name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+ = 3-methylcatechol + NADH + H+ + CO2." [EC:1.3.1.68] synonym: "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.68] xref: EC:1.3.1.68 xref: GO:0018521 xref: MetaCyc:1.3.1.68-RXN xref: UM-BBD_enzymeID:e0194 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003718 name: benzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + donor-H2 + 2 ATP = cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate." [EC:1.3.99.15] subset: gosubset_prok synonym: "benzoyl-CoA reductase (dearomatizing) activity" EXACT [EC:1.3.99.15] synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:acceptor oxidoreductase (aromatizing, ATP-forming)" EXACT [EC:1.3.99.15] xref: EC:1.3.99.15 xref: GO:0018522 xref: MetaCyc:1.3.99.15-RXN xref: UM-BBD_enzymeID:e0176 is_a: CCO:F0004055 ! acyl-CoA reductase activity [Term] id: CCO:F0003719 name: quinoline 2-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17] subset: gosubset_prok synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.17] xref: EC:1.3.99.17 xref: GO:0018523 xref: MetaCyc:1.3.99.17-RXN xref: UM-BBD_enzymeID:e0041 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0003720 name: acetophenone carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate." [UM-BBD_enzymeID:e0211] xref: EC:6.4.1.- xref: GO:0018524 xref: GO:0018797 xref: UM-BBD_enzymeID:e0211 is_a: CCO:F0003443 ! ligase activity, forming carbon-carbon bonds [Term] id: CCO:F0003721 name: 4-hydroxybenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + acceptor = benzoyl-CoA + reduced acceptor." [EC:1.3.99.20] subset: gosubset_prok synonym: "4-hydroxybenzoyl-CoA reductase (dehydroxylating) activity" EXACT [EC:1.3.99.20] synonym: "4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.20] synonym: "4-hydroxybenzoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.20] xref: EC:1.3.99.20 xref: GO:0018525 xref: MetaCyc:1.3.99.20-RXN xref: UM-BBD_enzymeID:e0159 is_a: CCO:F0004055 ! acyl-CoA reductase activity [Term] id: CCO:F0003722 name: 2-aminobenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [UM-BBD_enzymeID:e0263] xref: EC:1.4.-.- xref: GO:0018526 xref: UM-BBD_enzymeID:e0263 is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0003723 name: cyclohexylamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + H2O2." [EC:1.4.3.12] synonym: "cyclohexylamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.12] xref: EC:1.4.3.12 xref: GO:0018527 xref: MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN xref: UM-BBD_enzymeID:e0477 is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0003724 name: iminodiacetate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [UM-BBD_enzymeID:e0390] xref: EC:1.5.-.- xref: GO:0018528 xref: UM-BBD_enzymeID:e0390 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0003725 name: nitrilotriacetate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate." [UM-BBD_enzymeID:e0388] xref: EC:1.5.1.- xref: GO:0018529 xref: UM-BBD_enzymeID:e0388 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0003728 name: F433-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_enzymeID:e0265] synonym: "F433-independent methylene-H4MPT dehydrogenase activity" EXACT [] xref: EC:1.5.99.- xref: GO:0018532 xref: UM-BBD_enzymeID:e0265 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0003729 name: nitrilotriacetate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_enzymeID:e0389] xref: EC:1.5.99.- xref: GO:0018534 xref: UM-BBD_enzymeID:e0389 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0003730 name: nicotine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4] subset: gosubset_prok synonym: "D-nicotine oxidase activity" EXACT [EC:1.5.99.4] synonym: "nicotine oxidase activity" EXACT [EC:1.5.99.4] synonym: "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] synonym: "nicotine:acceptor 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] xref: EC:1.5.99.4 xref: GO:0018535 xref: MetaCyc:NICOTINE-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0337 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0003731 name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: N5,N10-methylenetetrahydromethanopterin + reduced coenzyme F420 = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme F420." [EC:1.5.99.11] subset: gosubset_prok synonym: "5,10-methylenetetrahydromethanopterin cyclohydrolase activity" EXACT [EC:1.5.99.11] synonym: "5,10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] synonym: "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "methylene-H(4)MPT reductase activity" EXACT [EC:1.5.99.11] synonym: "methylene-H4MPT reductase activity" EXACT [EC:1.5.99.11] synonym: "methylenetetrahydromethanopterin reductase activity" EXACT [] synonym: "N(5),N(10)-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] synonym: "N5,N10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] xref: EC:1.5.99.11 xref: GO:0018537 xref: MetaCyc:METHELENE-THMPT-OXI-RXN xref: UM-BBD_enzymeID:e0266 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0003732 name: epoxide carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ring opening and carboxylation of an epoxide; the reaction requires CO2 as a cosubstrate and forms a beta-keto acid as a products. An example of such a reaction is: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888] xref: EC:1.6.-.- xref: GO:0018538 is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0003733 name: p-benzoquinone reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + p-benzoquinone = NADP+ + hydroquinone." [EC:1.6.5.6] synonym: "NADPH:p-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.6] xref: EC:1.6.5.6 xref: GO:0018541 xref: MetaCyc:1.6.5.6-RXN xref: UM-BBD_enzymeID:e0422 is_a: CCO:F0003253 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: CCO:F0003734 name: 2,3-dihydroxy DDT 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_enzymeID:e0315] xref: EC:1.13.11.- xref: GO:0018542 xref: UM-BBD_enzymeID:e0315 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003735 name: 4-amino-2-nitroso-6-nitrotoluene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_enzymeID:e0365] xref: EC:1.6.6.- xref: GO:0018543 xref: UM-BBD_enzymeID:e0365 is_a: CCO:F0003255 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: CCO:F0003736 name: 4-carboxy-4'-sulfoazobenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_enzymeID:e0391] synonym: "4-carboxy-4'-sulphoazobenzene reductase activity" EXACT [] xref: EC:1.6.6.- xref: GO:0018544 xref: UM-BBD_enzymeID:e0391 is_a: CCO:F0003255 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: CCO:F0003737 name: NAD(P)H nitroreductase activity namespace: molecular_function xref: EC:1.6.6.- xref: GO:0018545 xref: UM-BBD_enzymeID:e0346 is_a: CCO:F0003255 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: CCO:F0003738 name: nitrobenzene nitroreductase activity namespace: molecular_function xref: EC:1.6.6.- xref: GO:0018546 xref: UM-BBD_enzymeID:e0245 is_a: CCO:F0003255 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: CCO:F0003739 name: nitroglycerin reductase activity namespace: molecular_function def: "Catalysis of the removal of one or more nitrite (NO2(-)) groups from nitroglycerin or a derivative." [UM-BBD_enzymeID:e0038] synonym: "NG reductase activity" EXACT [] xref: EC:1.7.3.- xref: GO:0018547 xref: UM-BBD_enzymeID:e0038 is_a: CCO:F0003258 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: CCO:F0003740 name: pentaerythritol tetranitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: pentaerythritol tri(or tetra)nitrate + NADPH = NADP+ + NO3- (nitrate) + pentaerythritol di(or tri)nitrate." [UM-BBD_enzymeID:e0035] xref: EC:1.7.99.- xref: GO:0018548 xref: UM-BBD_enzymeID:e0035 is_a: CCO:F0003256 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: CCO:F0003741 name: methanethiol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + H2O2." [EC:1.8.3.4] synonym: "(MM)-oxidase activity" EXACT [EC:1.8.3.4] synonym: "methanethiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.4] synonym: "methyl mercaptan oxidase activity" EXACT [EC:1.8.3.4] synonym: "methylmercaptan oxidase activity" EXACT [EC:1.8.3.4] synonym: "MT-oxidase activity" EXACT [EC:1.8.3.4] xref: EC:1.8.3.4 xref: GO:0018549 xref: MetaCyc:METHANETHIOL-OXIDASE-RXN xref: UM-BBD_enzymeID:e0153 is_a: CCO:F0003263 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor [Term] id: CCO:F0003742 name: tetrachloro-p-hyrodoquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: organohalide + 2 GSH = GSSG + HCl + RH. Substrates are 2,3,5,6-tetrachlorohydroquinone (TeCH) (forms 2,3,6-trichlorohydroquinone (TrCH)) and 2,3,6-trichlorohydroquinone (TrCH) (forms 2,6-dichlorohydroquinone (DiCH))." [UM-BBD_enzymeID:e0251] xref: EC:1.8.99.- xref: GO:0018550 xref: UM-BBD_enzymeID:e0251 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0003743 name: hydrogensulfite reductase activity namespace: molecular_function def: "Catalysis of the reaction: O3S-S-SO3(2-) + acceptor + 2 H2O + OH- = 3 HSO3(-) + reduced acceptor." [EC:1.8.99.3] subset: gosubset_prok synonym: "bisulfite reductase activity" EXACT [EC:1.8.99.3] synonym: "desulfofuscidin activity" NARROW [EC:1.8.99.3] synonym: "desulforubidin activity" NARROW [EC:1.8.99.3] synonym: "desulfoviridin activity" NARROW [EC:1.8.99.3] synonym: "dissimilatory sulfite reductase activity" EXACT [] synonym: "dissimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.3] synonym: "hydrogensulphite reductase activity" EXACT [] synonym: "trithionate:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.3] synonym: "trithionate:acceptor oxidoreductase activity" EXACT [EC:1.8.99.3] xref: EC:1.8.99.3 xref: GO:0018551 xref: MetaCyc:HYDROGENSULFITE-REDUCTASE-RXN xref: UM-BBD_enzymeID:e0416 is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0003744 name: methyl-coenzyme-M reductase activity namespace: molecular_function def: "Catalysis of the reaction: methyl-coenzyme-M + HTP = CoM-S-S-HTP + methane." [UM-BBD_enzymeID:e0267] xref: EC:1.12.99.- xref: GO:0018552 xref: UM-BBD_enzymeID:e0267 is_a: CCO:F0003281 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: CCO:F0003745 name: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [UM-BBD_enzymeID:e0309] xref: EC:1.13.-.- xref: GO:0018553 xref: UM-BBD_enzymeID:e0309 is_a: CCO:F0003285 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: CCO:F0008070 ! dioxygenase activity [Term] id: CCO:F0003746 name: 1,2-dihydroxynaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:e0255] xref: EC:1.13.-.- xref: GO:0018554 xref: UM-BBD_enzymeID:e0255 is_a: CCO:F0003285 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: CCO:F0008070 ! dioxygenase activity [Term] id: CCO:F0003747 name: phenanthrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ = cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_enzymeID:e0321] xref: EC:1.13.11.- xref: GO:0018555 xref: UM-BBD_enzymeID:e0321 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003748 name: 2,2',3-trihydroxybiphenyl dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032] xref: EC:1.13.11.- xref: GO:0018556 xref: UM-BBD_enzymeID:e0032 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003749 name: 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_enzymeID:e0295] xref: EC:1.13.11.- xref: GO:0018557 xref: UM-BBD_enzymeID:e0295 is_a: CCO:F0004063 ! dihydroxyfluorene dioxygenase activity [Term] id: CCO:F0003750 name: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_enzymeID:e0044] xref: EC:1.13.11.- xref: GO:0018558 xref: UM-BBD_enzymeID:e0044 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003751 name: 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_enzymeID:e0313] synonym: "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity" EXACT [] xref: EC:1.13.11.- xref: GO:0018559 xref: UM-BBD_enzymeID:e0313 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003752 name: protocatechuate 3,4-dioxygenase type II activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate." [UM-BBD_enzymeID:e0385] xref: EC:1.13.11.- xref: GO:0018560 xref: UM-BBD_enzymeID:e0385 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003753 name: 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_enzymeID:e0324] xref: EC:1.13.11.- xref: GO:0018561 xref: UM-BBD_enzymeID:e0324 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003754 name: 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_enzymeID:e0294] xref: EC:1.13.11.- xref: GO:0018562 xref: UM-BBD_enzymeID:e0294 is_a: CCO:F0004063 ! dihydroxyfluorene dioxygenase activity [Term] id: CCO:F0003755 name: 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_enzymeID:e0220] xref: EC:1.13.11.- xref: GO:0018563 xref: UM-BBD_enzymeID:e0220 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003756 name: carbazole 1,9a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol." [UM-BBD_enzymeID:e0323] xref: EC:1.13.11.- xref: GO:0018564 xref: UM-BBD_enzymeID:e0323 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003757 name: dihydroxydibenzothiophene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_enzymeID:e0162] xref: EC:1.13.11.- xref: GO:0018565 xref: UM-BBD_enzymeID:e0162 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003758 name: 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_enzymeID:e0250] synonym: "1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity" EXACT [] xref: EC:1.13.11.- xref: GO:0018566 xref: UM-BBD_enzymeID:e0250 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003759 name: styrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_enzymeID:e0200] xref: EC:1.13.11.- xref: GO:0018567 xref: UM-BBD_enzymeID:e0200 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003760 name: 3,4-dihydroxyphenanthrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_enzymeID:e0345] xref: EC:1.13.11.- xref: GO:0018568 xref: UM-BBD_enzymeID:e0345 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003761 name: hydroquinone 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0203] xref: EC:1.13.11.- xref: GO:0018569 xref: UM-BBD_enzymeID:e0203 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003762 name: p-cumate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_enzymeID:e0270] xref: EC:1.13.11.- xref: GO:0018570 xref: UM-BBD_enzymeID:e0270 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003763 name: 2,3-dihydroxy-p-cumate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [MetaCyc:RXN-666, UM-BBD_enzymeID:e0285] subset: gosubset_prok synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT [] synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT [] xref: EC:1.13.11.- xref: GO:0018571 xref: MetaCyc:RXN-666 xref: UM-BBD_enzymeID:e0285 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003764 name: 3,5-dichlorocatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H + 2,4-dichloro-cis,cis-muconate." [UM-BBD_enzymeID:e0231] xref: EC:1.13.11.- xref: GO:0018572 xref: UM-BBD_enzymeID:e0231 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003765 name: 2-aminophenol 1,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_enzymeID:e0247] xref: EC:1.13.11.- xref: GO:0018573 xref: UM-BBD_enzymeID:e0247 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003766 name: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422] xref: EC:1.13.11.- xref: GO:0018574 xref: UM-BBD_enzymeID:e0422 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003767 name: chlorocatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_enzymeID:e0419] xref: EC:1.13.11.- xref: GO:0018575 xref: UM-BBD_enzymeID:e0419 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003768 name: catechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = cis,cis-muconate." [EC:1.13.11.1] subset: gosubset_prok synonym: "1,2-pyrocatechase activity" EXACT [EC:1.13.11.1] synonym: "catechase activity" RELATED [EC:1.13.11.1] synonym: "catechol 1,2-oxygenase activity" EXACT [EC:1.13.11.1] synonym: "catechol-oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] synonym: "catechol:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] synonym: "CD I" RELATED [EC:1.13.11.1] synonym: "CD II" RELATED [EC:1.13.11.1] synonym: "pyrocatechase activity" RELATED [EC:1.13.11.1] synonym: "pyrocatechol 1,2-dioxygenase activity" EXACT [EC:1.13.11.1] xref: EC:1.13.11.1 xref: GO:0018576 xref: MetaCyc:CATECHOL-1 xref: UM-BBD_enzymeID:e0064 is_a: CCO:F0004060 ! catechol dioxygenase activity [Term] id: CCO:F0003769 name: catechol 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde." [EC:1.13.11.2] subset: gosubset_prok synonym: "2,3-pyrocatechase activity" EXACT [EC:1.13.11.2] synonym: "catechol 2,3-oxygenase" EXACT [EC:1.13.11.2] synonym: "catechol oxygenase" EXACT [EC:1.13.11.2] synonym: "catechol:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.2] synonym: "cato2ase activity" RELATED [EC:1.13.11.2] synonym: "metapyrocatechase activity" RELATED [EC:1.13.11.2] synonym: "pyrocatechol 2,3-dioxygenase" EXACT [EC:1.13.11.2] xref: EC:1.13.11.2 xref: GO:0018577 xref: MetaCyc:CATECHOL-2 xref: UM-BBD_enzymeID:e0156 is_a: CCO:F0004060 ! catechol dioxygenase activity [Term] id: CCO:F0003770 name: protocatechuate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3] subset: gosubset_prok synonym: "protocatechuate oxygenase activity" BROAD [EC:1.13.11.3] synonym: "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.3] synonym: "protocatechuic 3,4-dioxygenase activity" EXACT [EC:1.13.11.3] synonym: "protocatechuic 3,4-oxygenase activity" EXACT [EC:1.13.11.3] synonym: "protocatechuic acid oxidase activity" EXACT [EC:1.13.11.3] xref: EC:1.13.11.3 xref: GO:0018578 xref: MetaCyc:PROTOCATECHUATE-3 xref: UM-BBD_enzymeID:e0114 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003771 name: protocatechuate 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8] subset: gosubset_prok synonym: "protocatechuate 4,5-oxygenase activity" EXACT [EC:1.13.11.8] synonym: "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.8] synonym: "protocatechuic 4,5-dioxygenase activity" EXACT [EC:1.13.11.8] synonym: "protocatechuic 4,5-oxygenase activity" EXACT [EC:1.13.11.8] xref: EC:1.13.11.8 xref: GO:0018579 xref: MetaCyc:PROTOCATECHUATE-4 xref: UM-BBD_enzymeID:e0115 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003772 name: 2-nitropropane dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 2-nitropropane + O2 = 2 acetone + 2 NO2(-) (nitrite)." [EC:1.13.11.32] subset: gosubset_prok synonym: "2-nitropropane:oxygen 2-oxidoreductase activity" EXACT [EC:1.13.11.32] synonym: "2-NPD activity" EXACT [EC:1.13.11.32] synonym: "nitroalkane oxidase activity" EXACT [EC:1.13.11.32] xref: EC:1.13.11.32 xref: GO:0018580 xref: MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN xref: UM-BBD_enzymeID:e0387 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003773 name: hydroxyquinol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate." [EC:1.13.11.37] subset: gosubset_prok synonym: "benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.37] synonym: "hydroxyquinol dioxygenase activity" EXACT [EC:1.13.11.37] xref: EC:1.13.11.37 xref: GO:0018581 xref: MetaCyc:HYDROXYQUINOL-1 xref: UM-BBD_enzymeID:e0207 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003774 name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoate dioxygenase activity" EXACT [] synonym: "1-hydroxy-2-naphthoate-degrading enzyme activity" NARROW [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoic acid dioxygenase activity" EXACT [EC:1.13.11.38] xref: EC:1.13.11.38 xref: GO:0018582 xref: MetaCyc:1.13.11.38-RXN xref: UM-BBD_enzymeID:e0329 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003775 name: biphenyl-2,3-diol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39] subset: gosubset_prok synonym: "2,3-dihydroxybiphenyl 1,2-dioxygenase activity" BROAD [] synonym: "2,3-dihydroxybiphenyl dioxygenase activity" BROAD [EC:1.13.11.39] synonym: "biphenyl-2,3-diol dioxygenase activity" EXACT [EC:1.13.11.39] synonym: "biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.39] xref: EC:1.13.11.39 xref: GO:0018583 xref: MetaCyc:BIPHENYL-2 xref: UM-BBD_enzymeID:e0127 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0003776 name: 2,4,5-trichlorophenoxyacetic acid oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_enzymeID:e0276] xref: EC:1.13.99.- xref: GO:0018584 xref: UM-BBD_enzymeID:e0276 is_a: CCO:F0003285 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: CCO:F0003777 name: fluorene oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [UM-BBD_enzymeID:e0291] xref: EC:1.14.-.- xref: GO:0018585 xref: UM-BBD_enzymeID:e0291 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003778 name: mono-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: butyltin (MBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [UM-BBD_enzymeID:e0407] synonym: "MBT dioxygenase activity" EXACT [] xref: EC:1.14.-.- xref: GO:0018586 xref: UM-BBD_enzymeID:e0407 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003779 name: limonene 8-monooxygenase activity namespace: molecular_function xref: EC:1.14.-.- xref: GO:0018587 xref: UM-BBD_enzymeID:e0466 is_a: CCO:F0004059 ! limonene monooxygenase activity [Term] id: CCO:F0003780 name: tri-n-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tri-n-butyltin (TBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [UM-BBD_enzymeID:e0349] synonym: "TBT dioxygenase activity" EXACT [] xref: EC:1.14.-.- xref: GO:0018588 xref: UM-BBD_enzymeID:e0349 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003781 name: di-n-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibutyltin (DBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [UM-BBD_enzymeID:e0360] synonym: "DBT dioxygenase activity" EXACT [] xref: EC:1.14.-.- xref: GO:0018589 xref: UM-BBD_enzymeID:e0360 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003782 name: methylsilanetriol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [UM-BBD_enzymeID:e0343] xref: EC:1.14.-.- xref: GO:0018590 xref: UM-BBD_enzymeID:e0343 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003783 name: methyl tertiary butyl ether 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023] synonym: "MTBE 3-monooxygenase activity" EXACT [] xref: EC:1.14.-.- xref: GO:0018591 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003784 name: 4-nitrocatechol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + NO2(-) (nitrite) + 1,2,4-benzenetriol." [UM-BBD_enzymeID:e0206] xref: EC:1.14.-.- xref: GO:0018592 xref: UM-BBD_enzymeID:e0206 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003785 name: 4-chlorophenoxyacetate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [UM-BBD_enzymeID:e0234] xref: EC:1.14.-.- xref: GO:0018593 xref: UM-BBD_enzymeID:e0234 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003786 name: tert-butyl alcohol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tert-butyl alcohol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615] xref: EC:1.14.-.- xref: GO:0018594 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003787 name: alpha-pinene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_enzymeID:e0475] xref: EC:1.14.-.- xref: GO:0018595 xref: UM-BBD_enzymeID:e0475 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003788 name: dimethylsilanediol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [UM-BBD_enzymeID:e0288] synonym: "DMSD hydroxylase activity" EXACT [] xref: EC:1.14.-.- xref: GO:0018596 xref: UM-BBD_enzymeID:e0288 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003789 name: ammonia monooxygenase activity namespace: molecular_function subset: gosubset_prok xref: EC:1.14.-.- xref: GO:0018597 xref: UM-BBD_enzymeID:e0061 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003790 name: hydroxymethylsilanetriol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [UM-BBD_enzymeID:e0348] xref: EC:1.14.-.- xref: GO:0018598 xref: UM-BBD_enzymeID:e0348 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003791 name: 2-hydroxyisobutyrate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [UM-BBD_enzymeID:e0410] xref: EC:1.14.-.- xref: GO:0018599 xref: UM-BBD_enzymeID:e0410 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003792 name: alpha-pinene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_enzymeID:e0441] xref: EC:1.14.-.- xref: GO:0018600 xref: UM-BBD_enzymeID:e0441 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003793 name: 4-nitrophenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: p-nitrophenol + O2 + NADH + H+ = H2O + 4-nitrocatechol + NAD+." [EC:1.14.13.29, UM-BBD_enzymeID:e0205] synonym: "4-nitrophenol hydroxylase activity" EXACT [EC:1.14.13.29] synonym: "4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.29] synonym: "4-nitrophenol-2-hydroxylase activity" EXACT [EC:1.14.13.29] xref: EC:1.14.13.29 xref: GO:0018601 xref: MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0205 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003794 name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid = glyoxylate + 2,4-dichlorophenol." [UM-BBD_enzymeID:e0230] xref: EC:1.14.11.- xref: GO:0018602 xref: UM-BBD_enzymeID:e0230 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0003795 name: nitrobenzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + NO2(-) (nitrite) + catechol." [UM-BBD_enzymeID:e0248] xref: EC:1.14.12.- xref: GO:0018603 xref: UM-BBD_enzymeID:e0248 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003796 name: 4-aminobenzoate 3,4-dioxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_enzymeID:e0392] xref: EC:1.14.12.- xref: GO:0018604 xref: UM-BBD_enzymeID:e0392 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003797 name: 2-aminobenzenesulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + H+ + O2 = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_enzymeID:e0241] synonym: "2-aminobenzenesulphonate dioxygenase activity" EXACT [] xref: EC:1.14.12.- xref: GO:0018605 xref: UM-BBD_enzymeID:e0241 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003798 name: benzenesulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_enzymeID:e0242] synonym: "benzenesulphonate dioxygenase activity" EXACT [] xref: EC:1.14.12.- xref: GO:0018606 xref: UM-BBD_enzymeID:e0242 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003799 name: 1-indanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_enzymeID:e0298] xref: EC:1.14.12.- xref: GO:0018607 xref: UM-BBD_enzymeID:e0298 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003800 name: 1-indanone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_enzymeID:e0296] xref: EC:1.14.12.- xref: GO:0018608 xref: UM-BBD_enzymeID:e0296 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003801 name: chlorobenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062] xref: EC:1.14.12.- xref: GO:0018609 xref: UM-BBD_enzymeID:e0062 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003802 name: dibenzofuran 4,4a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN] xref: EC:1.14.12.- xref: GO:0018610 xref: MetaCyc:R606-RXN xref: UM-BBD_enzymeID:e0030 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003803 name: toluate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190] xref: EC:1.14.12.- xref: GO:0018611 xref: UM-BBD_enzymeID:e0190 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003804 name: dibenzothiophene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_enzymeID:e0160] xref: EC:1.14.12.- xref: GO:0018612 xref: UM-BBD_enzymeID:e0160 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003805 name: 9-fluorenone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_enzymeID:e0293] xref: EC:1.14.12.- xref: GO:0018613 xref: UM-BBD_enzymeID:e0293 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003806 name: ethylbenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_enzymeID:e0217] xref: EC:1.14.12.- xref: GO:0018614 xref: UM-BBD_enzymeID:e0217 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003807 name: 2-indanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_enzymeID:e0299] xref: EC:1.14.12.- xref: GO:0018615 xref: UM-BBD_enzymeID:e0299 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003808 name: trihydroxytoluene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [MetaCyc:R305-RXN, UM-BBD_enzymeID:e0074] xref: EC:1.14.12.- xref: GO:0018616 xref: MetaCyc:R305-RXN xref: UM-BBD_enzymeID:e0074 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003809 name: 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_enzymeID:e0393] synonym: "4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity" EXACT [] xref: EC:1.14.12.- xref: GO:0018617 xref: UM-BBD_enzymeID:e0393 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003810 name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1] subset: gosubset_prok synonym: "AntA" RELATED [] synonym: "AntB" RELATED [] synonym: "AntC" RELATED [] synonym: "anthranilate 1,2-dioxygenase" RELATED [] synonym: "anthranilate dioxygenase activity" EXACT [] synonym: "anthranilate dioxygenase reductase" NARROW [] synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.12.1] synonym: "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)" EXACT [EC:1.14.12.1] synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.12.1] synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.12.1] xref: EC:1.14.12.1 xref: GO:0018618 xref: MetaCyc:1.14.12.1-RXN xref: UM-BBD_enzymeID:e0371 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003811 name: benzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzene + NADH + H+ + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+." [EC:1.14.12.3] subset: gosubset_prok synonym: "benzene dioxygenase activity" EXACT [EC:1.14.12.3] synonym: "benzene hydroxylase activity" RELATED [EC:1.14.12.3] synonym: "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.3] xref: EC:1.14.12.3 xref: GO:0018619 xref: MetaCyc:BENZENE-1 xref: UM-BBD_enzymeID:e0059 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003812 name: phthalate 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+." [EC:1.14.12.7] subset: gosubset_prok synonym: "PDO activity" EXACT [EC:1.14.12.7] synonym: "phthalate dioxygenase activity" BROAD [EC:1.14.12.7] synonym: "phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)" EXACT [EC:1.14.12.7] xref: EC:1.14.12.7 xref: GO:0018620 xref: MetaCyc:PHTHALATE-4 xref: UM-BBD_enzymeID:e0104 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003813 name: 4-sulfobenzoate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfobenzoate + NADH + H+ + O2 = 3,4-dihydroxybenzoate + SO3(2-) (sulfite) + NAD+." [EC:1.14.12.8] synonym: "4-sulfobenzoate 3,4-dioxygenase system" RELATED [EC:1.14.12.8] synonym: "4-sulfobenzoate dioxygenase activity" EXACT [EC:1.14.12.8] synonym: "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)" EXACT [EC:1.14.12.8] synonym: "4-sulphobenzoate 3,4-dioxygenase activity" EXACT [] xref: EC:1.14.12.8 xref: GO:0018621 xref: MetaCyc:4-SULFOBENZOATE-3 xref: UM-BBD_enzymeID:e0128 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003814 name: 4-chlorophenylacetate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorophenyl acetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+." [EC:1.14.12.9] synonym: "4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)" EXACT [EC:1.14.12.9] xref: EC:1.14.12.9 xref: GO:0018622 xref: MetaCyc:1.14.12.9-RXN xref: UM-BBD_enzymeID:e0290 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003815 name: benzoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+." [EC:1.14.12.10] subset: gosubset_prok synonym: "benzoate dioxygenase activity" EXACT [EC:1.14.12.10] synonym: "benzoate hydroxylase activity" EXACT [EC:1.14.12.10] synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.10] synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)" EXACT [EC:1.14.12.10] synonym: "benzoic hydroxylase activity" EXACT [EC:1.14.12.10] xref: EC:1.14.12.10 xref: GO:0018623 xref: MetaCyc:BENZOATE-1 xref: UM-BBD_enzymeID:e0154 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003816 name: toluene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + NADH + H+ + O2 = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+." [EC:1.14.12.11] synonym: "toluene 1,2-dioxygenase activity" EXACT [EC:1.14.12.11] synonym: "toluene 2,3-dioxygenase activity" EXACT [EC:1.14.12.11] synonym: "toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.11] xref: EC:1.14.12.11 xref: GO:0018624 xref: MetaCyc:TOLUENE-DIOXYGENASE-RXN xref: UM-BBD_enzymeID:e0155 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003817 name: naphthalene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12] subset: gosubset_prok synonym: "naphthalene dioxygenase activity" EXACT [EC:1.14.12.12] synonym: "naphthalene oxygenase activity" EXACT [EC:1.14.12.12] synonym: "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.12] xref: EC:1.14.12.12 xref: GO:0018625 xref: MetaCyc:NAPHTHALENE-1 xref: UM-BBD_enzymeID:e0002 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003818 name: 2-chlorobenzoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13] subset: gosubset_prok synonym: "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)" EXACT [EC:1.14.12.13] synonym: "2-halobenzoate 1,2-dioxygenase activity" EXACT [] xref: EC:1.14.12.13 xref: GO:0018626 xref: MetaCyc:2-CHLOROBENZOATE-1 xref: UM-BBD_enzymeID:e0036 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003819 name: 2-aminobenzenesulfonate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminobenzenesulfonate + NADH + H+ + O2 = 2,3-dihydroxybenzenesulfonate + NH3 + NAD+." [EC:1.14.12.14] synonym: "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)" EXACT [EC:1.14.12.14] synonym: "2-aminobenzenesulphonate 2,3-dioxygenase activity" EXACT [] synonym: "2-aminosulfobenzene 2,3-dioxygenase activity" EXACT [EC:1.14.12.14] xref: EC:1.14.12.14 xref: GO:0018627 xref: MetaCyc:2ASDOSALCAL-RXN xref: UM-BBD_enzymeID:e0192 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003820 name: terephthalate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: terephthalate + NADH + H+ + O2 = (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+." [EC:1.14.12.15] synonym: "1,4-dicarboxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] synonym: "benzene-1,4-dicarboxylate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] synonym: "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.15] xref: EC:1.14.12.15 xref: GO:0018628 xref: MetaCyc:1.14.12.15-RXN xref: UM-BBD_enzymeID:e0107 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003821 name: 2-hydroxyquinoline 5,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16] synonym: "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity" EXACT [] synonym: "quinolin-2(1H)-one 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] synonym: "quinolin-2-ol 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] synonym: "quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)" EXACT [EC:1.14.12.16] xref: EC:1.14.12.16 xref: GO:0018629 xref: MetaCyc:1.14.12.16-RXN xref: UM-BBD_enzymeID:e0046 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003822 name: 3,5-xylenol methylhydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_enzymeID:e0287] xref: EC:1.14.13.- xref: GO:0018630 xref: MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN xref: UM-BBD_enzymeID:e0287 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003823 name: phenylacetate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate." [UM-BBD_enzymeID:e0197] xref: EC:1.14.13.- xref: GO:0018631 xref: UM-BBD_enzymeID:e0197 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003824 name: 4-nitrophenol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + NO2(-) (nitrite) + p-benzoquinone." [UM-BBD_enzymeID:e0201] xref: EC:1.14.13.- xref: GO:0018632 xref: UM-BBD_enzymeID:e0201 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003825 name: dimethyl sulfide monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde." [UM-BBD_enzymeID:e0189] synonym: "dimethyl sulphide monooxygenase activity" EXACT [] xref: EC:1.14.13.- xref: GO:0018633 xref: UM-BBD_enzymeID:e0189 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003826 name: alpha-pinene monooxygenase [NADH] activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [UM-BBD_enzymeID:e0443] xref: EC:1.14.13.- xref: GO:0018634 xref: UM-BBD_enzymeID:e0443 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003827 name: limonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-(4R)-limonene + NADH + O2 = NAD+ + OH- + (4R)-limonene-1,2-epoxide." [UM-BBD_enzymeID:e0462] xref: EC:1.14.13.- xref: GO:0018635 xref: UM-BBD_enzymeID:e0462 is_a: CCO:F0004059 ! limonene monooxygenase activity [Term] id: CCO:F0003828 name: phenanthrene 9,10-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [UM-BBD_enzymeID:e0334] xref: EC:1.14.13.- xref: GO:0018636 xref: UM-BBD_enzymeID:e0334 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003829 name: 1-hydroxy-2-naphthoate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [UM-BBD_enzymeID:e0332] xref: EC:1.14.13.- xref: GO:0018637 xref: UM-BBD_enzymeID:e0332 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003830 name: toluene 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene." [UM-BBD_enzymeID:e0225] xref: EC:1.14.13.- xref: GO:0018638 xref: UM-BBD_enzymeID:e0225 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003831 name: xylene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = benzyl alcohol or xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172] xref: EC:1.14.13.- xref: GO:0018639 xref: UM-BBD_enzymeID:e0172 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003832 name: dibenzothiophene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621] xref: EC:1.14.13.- xref: GO:0018640 xref: MetaCyc:RXN-621 xref: UM-BBD_enzymeID:e0214 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003833 name: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [UM-BBD_enzymeID:e0043] xref: EC:1.14.13.- xref: GO:0018641 xref: UM-BBD_enzymeID:e0043 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003834 name: chlorophenol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252] xref: EC:1.14.13.- xref: GO:0018642 xref: UM-BBD_enzymeID:e0252 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003835 name: carbon disulfide oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_enzymeID:e0401] synonym: "carbon disulphide oxygenase activity" EXACT [] xref: EC:1.14.13.- xref: GO:0018643 xref: UM-BBD_enzymeID:e0401 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003836 name: toluene 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [UM-BBD_enzymeID:e0222] xref: EC:1.14.13.- xref: GO:0018644 xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0222 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003837 name: alkene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69] synonym: "alkene epoxygenase activity" EXACT [EC:1.14.13.69] synonym: "alkene,NADH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.69] xref: EC:1.14.13.69 xref: GO:0018645 xref: MetaCyc:1.14.13.69-RXN xref: UM-BBD_enzymeID:e0039 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003838 name: 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_enzymeID:e0464] xref: EC:1.14.13.- xref: GO:0018646 xref: UM-BBD_enzymeID:e0464 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003839 name: phenanthrene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [UM-BBD_enzymeID:e0333] xref: EC:1.14.13.- xref: GO:0018647 xref: UM-BBD_enzymeID:e0333 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003840 name: methanesulfonic acid monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methanesulfonic acid + O2 + NADH = OH- + NAD+ + sulfurous acid + formaldehyde." [UM-BBD_enzymeID:e0264] synonym: "methanesulphonic acid monooxygenase activity" EXACT [] xref: EC:1.14.13.- xref: GO:0018648 xref: UM-BBD_enzymeID:e0264 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003841 name: tetrahydrofuran hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_enzymeID:e0015] xref: EC:1.14.13.- xref: GO:0018649 xref: UM-BBD_enzymeID:e0015 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003842 name: styrene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_enzymeID:e0195] xref: EC:1.14.13.- xref: GO:0018650 xref: UM-BBD_enzymeID:e0195 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003843 name: toluene-4-sulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_enzymeID:e0243] synonym: "toluene-4-sulphonate monooxygenase activity" EXACT [] xref: EC:1.14.13.- xref: GO:0018651 xref: UM-BBD_enzymeID:e0243 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003844 name: toluene-sulfonate methyl-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [UM-BBD_enzymeID:e0238] synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT [] xref: EC:1.14.13.- xref: GO:0018652 xref: UM-BBD_enzymeID:e0238 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003845 name: 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [EC:1.14.13.-] xref: EC:1.14.13.- xref: GO:0018653 xref: UM-BBD_enzymeID:e0042 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003846 name: 2-hydroxy-phenylacetate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [UM-BBD_enzymeID:e0198] xref: EC:1.14.13.- xref: GO:0018654 xref: UM-BBD_enzymeID:e0198 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003847 name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_enzymeID:e0304] xref: EC:1.14.13.- xref: GO:0018655 xref: UM-BBD_enzymeID:e0304 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003848 name: phenanthrene 3,4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [UM-BBD_enzymeID:e0347] xref: EC:1.14.13.- xref: GO:0018656 xref: UM-BBD_enzymeID:e0347 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003849 name: toluene 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene." [UM-BBD_enzymeID:e0224] xref: EC:1.14.13.- xref: GO:0018657 xref: MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0224 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003850 name: salicylate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1] subset: gosubset_prok synonym: "salicylate 1-hydroxylase activity" EXACT [EC:1.14.13.1] synonym: "salicylate hydroxylase (decarboxylating)" EXACT [EC:1.14.13.1] synonym: "salicylate hydroxylase activity" EXACT [] synonym: "salicylate monooxygenase activity" EXACT [EC:1.14.13.1] synonym: "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.1] synonym: "salicylic hydroxylase activity" EXACT [EC:1.14.13.1] xref: EC:1.14.13.1 xref: GO:0018658 xref: MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0149 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003851 name: 4-hydroxybenzoate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2] subset: gosubset_prok synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "4-hydroxybenzoate monooxygenase activity" EXACT [EC:1.14.13.2] synonym: "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoate hydrolyase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "p-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoic acid hydrolase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoic acid hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "p-hydroxybenzoic hydroxylase activity" EXACT [EC:1.14.13.2] synonym: "para-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] xref: EC:1.14.13.2 xref: GO:0018659 xref: MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0084 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003852 name: 4-hydroxyphenylacetate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [EC:1.14.13.3] subset: gosubset_prok synonym: "4 HPA 3-hydroxylase activity" EXACT [EC:1.14.13.3] synonym: "4-hydroxyphenylacetate 3-hydroxylase activity" EXACT [] synonym: "4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.3] synonym: "4-hydroxyphenylacetic acid-3-hydroxylase activity" EXACT [EC:1.14.13.3] synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" EXACT [EC:1.14.13.3] synonym: "p-hydroxyphenylacetate hydroxylase activity" EXACT [EC:1.14.13.3] xref: EC:1.14.13.3 xref: GO:0018660 xref: MetaCyc:1.14.13.3-RXN xref: UM-BBD_enzymeID:e0150 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003853 name: orcinol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: orcinol + NADH + H+ + O2 = 2,3,5-trihydroxytoluene + NAD+ + H2O." [EC:1.14.13.6] synonym: "orcinol hydroxylase activity" EXACT [] synonym: "orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.6] xref: EC:1.14.13.6 xref: GO:0018661 xref: MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0073 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003854 name: phenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O." [EC:1.14.13.7] subset: gosubset_prok synonym: "phenol hydroxylase activity" EXACT [EC:1.14.13.7] synonym: "phenol o-hydroxylase activity" EXACT [EC:1.14.13.7] synonym: "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.7] xref: EC:1.14.13.7 xref: GO:0018662 xref: MetaCyc:PHENOL-2-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0208 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003855 name: 2,6-dihydroxypyridine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxypyridine + NADH + H+ + O2 = 2,3,6-trihydroxypyridine + NAD+ + H2O." [EC:1.14.13.10] synonym: "2,6-dihydroxypyridine oxidase activity" EXACT [] synonym: "2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.10] xref: EC:1.14.13.10 xref: GO:0018663 xref: MetaCyc:1.14.13.10-RXN xref: UM-BBD_enzymeID:e0340 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003856 name: benzoate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + NADPH + H+ + O2 = 4-hydroxybenzoate + NADP+ + H2O." [EC:1.14.13.12] synonym: "4-hydroxybenzoic hydroxylase activity" EXACT [] synonym: "benzoate 4-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.12] synonym: "benzoate-p-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoate-para-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoic 4-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoic acid 4-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "p-hydroxybenzoate hydroxylase activity" EXACT [EC:1.14.13.12] xref: EC:1.14.13.12 xref: GO:0018664 xref: MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0414 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003857 name: 4-hydroxyphenylacetate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18] synonym: "4-HPA 1-hydroxylase activity" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenyl-acetate 1-hydroxylase activity" EXACT [] synonym: "4-hydroxyphenylacetate 1-hydroxylase activity" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenylacetic 1-hydroxylase activity" EXACT [EC:1.14.13.18] xref: EC:1.14.13.18 xref: GO:0018665 xref: MetaCyc:1.14.13.18-RXN xref: UM-BBD_enzymeID:e0151 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003858 name: 2,4-dichlorophenol 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20] subset: gosubset_prok synonym: "2,4-dichlorophenol hydroxylase activity" EXACT [] synonym: "2,4-dichlorophenol monooxygenase activity" EXACT [EC:1.14.13.20] synonym: "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.20] xref: EC:1.14.13.20 xref: GO:0018666 xref: MetaCyc:2 xref: UM-BBD_enzymeID:e0152 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003859 name: cyclohexanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22] subset: gosubset_prok synonym: "cyclohexanone 1,2-monooxygenase activity" EXACT [] synonym: "cyclohexanone oxygenase activity" EXACT [EC:1.14.13.22] synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity" EXACT [EC:1.14.13.22] synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)" EXACT [EC:1.14.13.22] xref: EC:1.14.13.22 xref: GO:0018667 xref: MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0166 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003860 name: 3-hydroxybenzoate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O." [EC:1.14.13.23] synonym: "3-hydroxybenzoate 4-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.23] xref: EC:1.14.13.23 xref: GO:0018668 xref: MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0109 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003861 name: 3-hydroxybenzoate 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O." [EC:1.14.13.24] synonym: "3-hydroxybenzoate 6-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.24] synonym: "3-hydroxybenzoic acid-6-hydroxylase activity" EXACT [EC:1.14.13.24] synonym: "m-hydroxybenzoate 6-hydroxylase activity" EXACT [EC:1.14.13.24] xref: EC:1.14.13.24 xref: GO:0018669 xref: MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0289 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003862 name: 4-aminobenzoate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27] synonym: "4-aminobenzoate dehydrogenase activity" EXACT [EC:1.14.13.27] synonym: "4-aminobenzoate hydroxylase activity" EXACT [] synonym: "4-aminobenzoate monooxygenase activity" EXACT [EC:1.14.13.27] synonym: "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.27] xref: EC:1.14.13.27 xref: GO:0018670 xref: MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0400 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003863 name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33] synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.33] synonym: "4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))" EXACT [] synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.33] synonym: "4-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.33] xref: EC:1.14.13.33 xref: GO:0018671 xref: MetaCyc:1.14.13.33-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003864 name: anthranilate 3-monooxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3." [EC:1.14.13.35] synonym: "anthranilate 2,3-dioxygenase (deaminating)" EXACT [EC:1.14.13.35] synonym: "anthranilate 2,3-hydroxylase (deaminating) activity" EXACT [EC:1.14.13.35] synonym: "anthranilate hydroxylase (deaminating) activity" EXACT [] synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.13.35] synonym: "anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)" EXACT [EC:1.14.13.35] xref: EC:1.14.13.35 xref: GO:0018672 xref: MetaCyc:1.14.13.35-RXN xref: UM-BBD_enzymeID:e0382 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003865 name: anthraniloyl-CoA monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40] subset: gosubset_prok synonym: "2-aminobenzoyl-CoA monooxygenase/reductase activity" EXACT [EC:1.14.13.40] synonym: "2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)" EXACT [EC:1.14.13.40] synonym: "anthraniloyl coenzyme A reductase activity" EXACT [EC:1.14.13.40] xref: EC:1.14.13.40 xref: GO:0018673 xref: MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0370 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003869 name: pentachlorophenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50] subset: gosubset_prok synonym: "PCB 4-monooxygenase activity" EXACT [EC:1.14.13.50] synonym: "PCB4MO activity" EXACT [EC:1.14.13.50] synonym: "PCP hydroxylase activity" EXACT [EC:1.14.13.50] synonym: "PcpB" RELATED [EC:1.14.13.50] synonym: "pentachlorophenol 4-monooxygenase activity" EXACT [] synonym: "pentachlorophenol dechlorinase activity" EXACT [EC:1.14.13.50] synonym: "pentachlorophenol dehalogenase activity" EXACT [EC:1.14.13.50] synonym: "pentachlorophenol hydroxylase activity" EXACT [] synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" EXACT [EC:1.14.13.50] xref: EC:1.14.13.50 xref: GO:0018677 xref: MetaCyc:PENTACHLOROPHENOL-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0148 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003870 name: 4-hydroxybenzoate 1-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64] synonym: "4-hydroxybenzoate 1-monooxygenase activity" EXACT [] synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.64] xref: EC:1.14.13.64 xref: GO:0018678 xref: MetaCyc:1.14.13.64-RXN xref: UM-BBD_enzymeID:e0476 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003871 name: dibenzothiophene-5,5-dioxide monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate." [UM-BBD_enzymeID:e0215] xref: EC:1.14.14.- xref: GO:0018679 xref: UM-BBD_enzymeID:e0215 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003872 name: deethylatrazine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_enzymeID:e0098] xref: EC:1.14.15.- xref: GO:0018680 xref: UM-BBD_enzymeID:e0098 is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003873 name: deisopropylatrazine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 CH3CHO + 2 deisopropyldeethylatrazine." [UM-BBD_enzymeID:e0094] xref: EC:1.14.15.- xref: GO:0018681 xref: UM-BBD_enzymeID:e0094 is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003874 name: atrazine monooxygenase activity namespace: molecular_function xref: EC:1.14.15.- xref: GO:0018682 xref: UM-BBD_enzymeID:e0090 is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003875 name: camphor 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1] subset: gosubset_prok synonym: "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.15.1] synonym: "2-bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor 5-exo-methylene hydroxylase activity" EXACT [] synonym: "camphor 5-exohydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor methylene hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "cytochrome p450-cam activity" EXACT [EC:1.14.15.1] synonym: "d-camphor monooxygenase activity" EXACT [EC:1.14.15.1] synonym: "D-camphor-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "methylene hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "methylene monooxygenase activity" EXACT [EC:1.14.15.1] xref: EC:1.14.15.1 xref: GO:0018683 xref: MetaCyc:R541-RXN xref: UM-BBD_enzymeID:e0300 is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003876 name: camphor 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-bornane-2,5-dione + reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + H2O." [EC:1.14.15.2] synonym: "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.15.2] synonym: "2,5-diketocamphane lactonizing enzyme activity" EXACT [EC:1.14.15.2] synonym: "camphor ketolactonase I activity" EXACT [EC:1.14.15.2] synonym: "ketolactonase I" RELATED [EC:1.14.15.2] synonym: "oxygenase, camphor 1,2-mono" EXACT [EC:1.14.15.2] xref: EC:1.14.15.2 xref: GO:0018684 xref: MetaCyc:CAMPHOR-1 xref: UM-BBD_enzymeID:e0302 is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003877 name: alkane 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] subset: gosubset_prok synonym: "1-hydroxylase activity" EXACT [EC:1.14.15.3] synonym: "alkane 1-hydroxylase activity" EXACT [] synonym: "alkane hydroxylase activity" EXACT [EC:1.14.15.3] synonym: "alkane monooxygenase activity" EXACT [EC:1.14.15.3] synonym: "alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity" EXACT [EC:1.14.15.3] synonym: "fatty acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3] xref: EC:1.14.15.3 xref: GO:0018685 xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0022 is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003878 name: 6-hydroxy pseudo-oxynicotine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [UM-BBD_enzymeID:e0342] xref: EC:1.14.18.- xref: GO:0018686 xref: UM-BBD_enzymeID:e0342 is_a: CCO:F0003299 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0003879 name: biphenyl 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD; requires Fe2+." [EC:1.14.12.18] subset: gosubset_prok synonym: "biphenyl dioxygenase activity" EXACT [EC:1.14.12.18] synonym: "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)" EXACT [EC:1.14.12.18] xref: EC:1.14.12.18 xref: GO:0018687 xref: MetaCyc:1.14.12.18-RXN xref: UM-BBD_enzymeID:e0089 is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0003880 name: DDT 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [UM-BBD_enzymeID:e0319] xref: EC:1.14.99.- xref: GO:0018688 xref: UM-BBD_enzymeID:e0319 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: CCO:F0008070 ! dioxygenase activity [Term] id: CCO:F0003881 name: naphthalene disulfonate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [UM-BBD_enzymeID:e0249] synonym: "naphthalene disulphonate 1,2-dioxygenase activity" EXACT [] xref: EC:1.14.99.- xref: GO:0018689 xref: UM-BBD_enzymeID:e0249 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003882 name: 4-methoxybenzoate monooxygenase (O-demethylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-methoxybenzoate + donor-H2 + O2 = 4-hydroxybenzoate + formaldehyde + acceptor + H2O." [EC:1.14.99.15] synonym: "4-methoxybenzoate 4-monooxygenase (O-demethylating)" EXACT [EC:1.14.99.15] synonym: "4-methoxybenzoate monooxygenase activity" EXACT [] synonym: "4-methoxybenzoate O-demethylase activity" EXACT [EC:1.14.99.15] synonym: "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)" EXACT [EC:1.14.99.15] synonym: "p-anisic O-demethylase activity" EXACT [EC:1.14.99.15] synonym: "piperonylate-4-O-demethylase activity" EXACT [EC:1.14.99.15] xref: EC:1.14.99.15 xref: GO:0018690 xref: MetaCyc:1.14.99.15-RXN xref: UM-BBD_enzymeID:e0103 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0003883 name: arsenite oxidase activity namespace: molecular_function def: "Catalysis of the reaction: arsenite + 10 H2O = 20 H+ + 8 e- + arsenate." [UM-BBD_enzymeID:e0037] xref: EC:1.16.-.- xref: GO:0018691 xref: UM-BBD_enzymeID:e0037 is_a: CCO:F0003304 ! oxidoreductase activity, oxidizing metal ions [Term] id: CCO:F0003884 name: ethylbenzene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor." [EC:1.17.99.2] synonym: "ethylbenzene dehydrogenase activity" EXACT [EC:1.17.99.2] synonym: "ethylbenzene:(acceptor) oxidoreductase activity" EXACT [EC:1.17.99.2] xref: EC:1.17.99.2 xref: GO:0018693 xref: UM-BBD_enzymeID:e0209 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0003885 name: p-cymene methyl hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_enzymeID:e0199] xref: EC:1.17.99.- xref: GO:0018694 xref: UM-BBD_enzymeID:e0199 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0003886 name: 4-cresol dehydrogenase (hydroxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.99.1] subset: gosubset_prok synonym: "4-cresol dehydrogenase activity" EXACT [] synonym: "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)" EXACT [EC:1.17.99.1] synonym: "p-cresol methylhydroxylase activity" EXACT [EC:1.17.99.1] synonym: "p-cresol-(acceptor) oxidoreductase (hydroxylating) activity" EXACT [EC:1.17.99.1] xref: EC:1.17.99.1 xref: GO:0018695 xref: MetaCyc:1.17.99.1-RXN xref: UM-BBD_enzymeID:e0147 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0003887 name: carbonyl sulfide nitrogenase activity namespace: molecular_function def: "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = H2S + carbon monoxide." [UM-BBD_enzymeID:e0402] synonym: "carbonyl sulphide nitrogenase activity" EXACT [] xref: EC:1.18.6.- xref: GO:0018697 xref: UM-BBD_enzymeID:e0402 is_a: CCO:F0003313 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor [Term] id: CCO:F0003888 name: vinyl chloride reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene (ethylene)." [UM-BBD_enzymeID:e0273] xref: EC:1.97.1.- xref: GO:0018698 xref: UM-BBD_enzymeID:e0273 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003889 name: trichloroethane reductive dehalogenase activity namespace: molecular_function xref: EC:1.97.1.- xref: GO:0018699 xref: UM-BBD_enzymeID:e0271 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003890 name: 2-chloro-N-isopropylacetanilide reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_enzymeID:e0450] xref: EC:1.97.1.- xref: GO:0018700 xref: UM-BBD_enzymeID:e0450 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003891 name: 2,5-dichlorohydroquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366] xref: EC:1.97.1.- xref: GO:0018701 xref: UM-BBD_enzymeID:e0366 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003892 name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_enzymeID:e0312] synonym: "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity" EXACT [] synonym: "DDE dehalogenase activity" EXACT [] xref: EC:1.97.1.- xref: GO:0018702 xref: UM-BBD_enzymeID:e0312 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003893 name: 2,4-dichlorophenoxyacetate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [UM-BBD_enzymeID:e0233] xref: GO:0018703 xref: UM-BBD_enzymeID:e0233 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003894 name: 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0237] xref: EC:1.97.1.- xref: GO:0018704 xref: UM-BBD_enzymeID:e0237 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003895 name: 1,2-dichloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [UM-BBD_enzymeID:e0272] synonym: "1,2-dichloroethylene reductive dehalogenase activity" EXACT [] xref: GO:0018705 xref: UM-BBD_enzymeID:e0272 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003896 name: pyrogallol hydroxytransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [EC:1.97.1.2] subset: gosubset_prok synonym: "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity" EXACT [EC:1.97.1.2] synonym: "pyrogallol hydroxyltransferase activity" EXACT [] synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2] xref: EC:1.97.1.2 xref: GO:0018706 xref: MetaCyc:1.97.1.2-RXN xref: UM-BBD_enzymeID:e0009 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0003897 name: 1-phenanthrol methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [UM-BBD_enzymeID:e0336] xref: EC:2.1.1.- xref: GO:0018707 xref: UM-BBD_enzymeID:e0336 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0003898 name: thiol S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9] synonym: "S-adenosyl-L-methionine:thiol S-methyltransferase activity" EXACT [EC:2.1.1.9] synonym: "thiol methyltransferase activity" EXACT [EC:2.1.1.9] synonym: "TMT" RELATED [EC:2.1.1.9] xref: EC:2.1.1.9 xref: GO:0018708 xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN xref: Reactome:9948 xref: UM-BBD_enzymeID:e0146 is_a: CCO:F0001759 ! S-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0003899 name: acetone carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: acetone + ATP + 2 H2O + CO2 = AMP + 2 phosphate + acetoacetate." [EC:6.4.1.6] synonym: "acetone:carbon-dioxide ligase (AMP-forming)" EXACT [EC:6.4.1.6] xref: EC:6.4.1.6 xref: GO:0018710 xref: MetaCyc:6.4.1.6-RXN is_a: CCO:F0003443 ! ligase activity, forming carbon-carbon bonds [Term] id: CCO:F0003900 name: benzoyl acetate-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_enzymeID:e0213] xref: EC:2.3.1.- xref: GO:0018711 xref: UM-BBD_enzymeID:e0213 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0003901 name: 3-hydroxybutyryl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_enzymeID:e0013] xref: EC:2.3.1.- xref: GO:0018712 xref: UM-BBD_enzymeID:e0013 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0003902 name: 3-ketopimelyl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_enzymeID:e0182] xref: EC:2.3.1.- xref: GO:0018713 xref: UM-BBD_enzymeID:e0182 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0003903 name: 9-phenanthrol UDP-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [UM-BBD_enzymeID:e0377] xref: EC:2.4.1.- xref: GO:0018715 xref: UM-BBD_enzymeID:e0377 is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0003904 name: 1-phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_enzymeID:e0356] xref: EC:2.4.1.- xref: GO:0018716 xref: UM-BBD_enzymeID:e0356 is_a: CCO:F0004058 ! phenanthrol glycosyltransferase activity [Term] id: CCO:F0003905 name: 9-phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_enzymeID:e0350] xref: EC:2.4.1.- xref: GO:0018717 xref: UM-BBD_enzymeID:e0350 is_a: CCO:F0004058 ! phenanthrol glycosyltransferase activity [Term] id: CCO:F0003906 name: 1,2-dihydroxy-phenanthrene glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [UM-BBD_enzymeID:e0378] xref: EC:2.4.1.- xref: GO:0018718 xref: UM-BBD_enzymeID:e0378 is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0003907 name: 6-aminohexanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_enzymeID:e0318] xref: EC:2.6.1.- xref: GO:0018719 xref: UM-BBD_enzymeID:e0318 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0003908 name: phenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate." [UM-BBD_enzymeID:e0157] xref: EC:2.7.1.- xref: GO:0018720 xref: UM-BBD_enzymeID:e0157 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0003909 name: trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [UM-BBD_enzymeID:e0369] synonym: "trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0018721 xref: UM-BBD_enzymeID:e0369 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0003910 name: 1-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [UM-BBD_enzymeID:e0373] synonym: "1-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0018722 xref: UM-BBD_enzymeID:e0373 is_a: CCO:F0004057 ! phenanthrol sulfotransferase activity [Term] id: CCO:F0003911 name: 3-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [UM-BBD_enzymeID:e0374] synonym: "3-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0018723 xref: UM-BBD_enzymeID:e0374 is_a: CCO:F0004057 ! phenanthrol sulfotransferase activity [Term] id: CCO:F0003912 name: 4-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [UM-BBD_enzymeID:e0375] synonym: "4-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0018724 xref: UM-BBD_enzymeID:e0375 is_a: CCO:F0004057 ! phenanthrol sulfotransferase activity [Term] id: CCO:F0003913 name: trans-3,4-dihydrodiolphenanthrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [UM-BBD_enzymeID:e0368] synonym: "trans-3,4-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0018725 xref: UM-BBD_enzymeID:e0368 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0003914 name: 9-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [UM-BBD_enzymeID:e0376] synonym: "9-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0018726 xref: UM-BBD_enzymeID:e0376 is_a: CCO:F0004057 ! phenanthrol sulfotransferase activity [Term] id: CCO:F0003915 name: 2-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [UM-BBD_enzymeID:e0372] synonym: "2-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0018727 xref: UM-BBD_enzymeID:e0372 is_a: CCO:F0004057 ! phenanthrol sulfotransferase activity [Term] id: CCO:F0003916 name: succinyl-CoA:benzylsuccinate CoA-transferase activity namespace: molecular_function xref: EC:2.8.3.- xref: GO:0018728 xref: UM-BBD_enzymeID:e0260 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0003917 name: propionate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA." [EC:2.8.3.1] subset: gosubset_prok synonym: "acetyl-CoA:propanoate CoA-transferase activity" EXACT [EC:2.8.3.1] synonym: "propionate coenzyme A-transferase activity" EXACT [EC:2.8.3.1] synonym: "propionate-CoA:lactoyl-CoA transferase activity" EXACT [EC:2.8.3.1] synonym: "propionyl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.1] synonym: "propionyl-CoA transferase activity" EXACT [EC:2.8.3.1] xref: EC:2.8.3.1 xref: GO:0018729 xref: MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN xref: UM-BBD_enzymeID:e0071 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0003918 name: glutaconate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12] subset: gosubset_prok synonym: "acetyl-CoA:(E)-glutaconate CoA-transferase activity" EXACT [EC:2.8.3.12] xref: EC:2.8.3.12 xref: GO:0018730 xref: MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN xref: UM-BBD_enzymeID:e0069 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0003919 name: 1-oxa-2-oxocycloheptane lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [UM-BBD_enzymeID:e0167] xref: EC:3.1.1.- xref: GO:0018731 xref: UM-BBD_enzymeID:e0167 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0003920 name: sulfolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [UM-BBD_enzymeID:e0384] synonym: "sulpholactone hydrolase activity" EXACT [] xref: EC:3.1.1.- xref: GO:0018732 xref: UM-BBD_enzymeID:e0384 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0003921 name: 3,4-dihydrocoumarin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [UM-BBD_enzymeID:e0297] xref: EC:3.1.1.- xref: GO:0018733 xref: UM-BBD_enzymeID:e0297 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0003922 name: butyrolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate." [UM-BBD_enzymeID:e0017] xref: EC:3.1.1.- xref: GO:0018734 xref: UM-BBD_enzymeID:e0017 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0003923 name: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [UM-BBD_enzymeID:e0187] xref: EC:3.7.1.- xref: GO:0018736 xref: UM-BBD_enzymeID:e0187 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003924 name: 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [UM-BBD_enzymeID:e0178] xref: EC:3.7.1.- xref: GO:0018737 xref: UM-BBD_enzymeID:e0178 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003925 name: S-formylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-formylglutathione + H2O = glutathione + formate." [EC:3.1.2.12] subset: gosubset_prok xref: EC:3.1.2.12 xref: GO:0018738 xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN xref: UM-BBD_enzymeID:e0141 is_a: CCO:F0003361 ! thiolester hydrolase activity [Term] id: CCO:F0003926 name: 4-hydroxybenzoyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA." [EC:3.1.2.23] subset: gosubset_prok synonym: "4-hydroxybenzoyl-CoA hydrolase activity" EXACT [EC:3.1.2.23] synonym: "4-hydroxybenzoyl-CoA thiolesterase activity" EXACT [] xref: EC:3.1.2.23 xref: GO:0018739 xref: MetaCyc:3.1.2.23-RXN xref: UM-BBD_enzymeID:e0118 is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0003927 name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(2-hydroxyphenyl)benzenesulfinate + H2O = 2-hydroxybiphenyl + SO3(2-) (sulfite)." [EC:3.13.1.3] subset: gosubset_prok synonym: "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity" EXACT [] synonym: "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity" EXACT [] synonym: "dibenzothiophene desulfurization enzyme B" RELATED [EC:3.13.1.3] synonym: "DszB" RELATED [EC:3.13.1.3] synonym: "gene dszB-encoded hydrolase activity" EXACT [EC:3.13.1.3] synonym: "HBPSi desulfinase activity" EXACT [EC:3.13.1.3] synonym: "HPBS desulfinase activity" EXACT [EC:3.13.1.3] xref: EC:3.13.1.3 xref: GO:0018740 xref: MetaCyc:RXN-624 xref: UM-BBD_enzymeID:e0216 is_a: CCO:F0006192 ! hydrolase activity, acting on carbon-sulfur bonds [Term] id: CCO:F0003928 name: alkyl sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: dodecyl sulfate + H2O = SO4(2-) (sulfate) + H+ + 1-dodecanol." [UM-BBD_enzymeID:e0403] synonym: "alkyl sulphatase activity" EXACT [] xref: EC:3.1.6.- xref: GO:0018741 xref: UM-BBD_enzymeID:e0403 is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0003929 name: epoxide hydrolase B activity namespace: molecular_function def: "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [UM-BBD_enzymeID:e0051] xref: EC:3.3.2.- xref: GO:0018742 xref: UM-BBD_enzymeID:e0051 is_a: CCO:F0000723 ! epoxide hydrolase activity [Term] id: CCO:F0003930 name: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0367] xref: EC:3.3.2.- xref: GO:0018743 xref: UM-BBD_enzymeID:e0367 is_a: CCO:F0004065 ! phenanthrene-9,10-epoxide hydrolase activity [Term] id: CCO:F0003931 name: limonene-1,2-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8] subset: gosubset_prok synonym: "limonene oxide hydrolase activity" EXACT [EC:3.3.2.8] xref: EC:3.3.2.8 xref: GO:0018744 xref: MetaCyc:3.3.2.8-RXN xref: UM-BBD_enzymeID:e0470 is_a: CCO:F0000723 ! epoxide hydrolase activity [Term] id: CCO:F0003932 name: epoxide hydrolase A activity namespace: molecular_function def: "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [UM-BBD_enzymeID:e0049] xref: EC:3.3.2.- xref: GO:0018745 xref: UM-BBD_enzymeID:e0049 is_a: CCO:F0000723 ! epoxide hydrolase activity [Term] id: CCO:F0003933 name: phenanthrene-3,4-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0363] xref: EC:3.3.2.- xref: GO:0018746 xref: UM-BBD_enzymeID:e0363 is_a: CCO:F0004064 ! phenanthrene-epoxide hydrolase activity [Term] id: CCO:F0003934 name: phenanthrene-1,2-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0364] xref: EC:3.3.2.- xref: GO:0018747 xref: UM-BBD_enzymeID:e0364 is_a: CCO:F0004064 ! phenanthrene-epoxide hydrolase activity [Term] id: CCO:F0003935 name: iprodione amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [UM-BBD_enzymeID:e0438] xref: EC:3.5.1.- xref: GO:0018748 xref: UM-BBD_enzymeID:e0438 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0003937 name: biuret amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3." [EC:3.5.1.84] xref: EC:3.5.1.84 xref: GO:0018750 xref: MetaCyc:R469-RXN xref: UM-BBD_enzymeID:e0088 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0003938 name: 3,5-dichlorophenylcarboximide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [UM-BBD_enzymeID:e0439] xref: EC:3.5.2.- xref: GO:0018751 xref: UM-BBD_enzymeID:e0439 is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0003939 name: epsilon-caprolactam lactamase activity namespace: molecular_function def: "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_enzymeID:e0317] xref: EC:3.5.2.- xref: GO:0018752 xref: UM-BBD_enzymeID:e0317 is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0003940 name: cyanuric acid amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2." [EC:3.5.2.15] subset: gosubset_prok xref: EC:3.5.2.15 xref: GO:0018753 xref: MetaCyc:R468-RXN xref: UM-BBD_enzymeID:e0087 is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0003941 name: ammelide aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3." [PMID:1991731] xref: EC:3.5.3.- xref: GO:0018754 is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0003942 name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity namespace: molecular_function def: "2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414] xref: EC:3.5.3.- xref: GO:0018755 is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0003943 name: ammeline aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731] xref: EC:3.5.3.- xref: GO:0018756 is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0003944 name: deisopropylhydroxyatrazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_enzymeID:e0092] xref: EC:3.5.3.- xref: GO:0018757 xref: UM-BBD_enzymeID:e0092 is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0003945 name: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [UM-BBD_enzymeID:e0093] xref: EC:3.5.3.- xref: GO:0018758 xref: UM-BBD_enzymeID:e0093 is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0003946 name: methenyltetrahydromethanopterin cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N5-formyl-5,6,7,8-tetrahydromethanopterin." [EC:3.5.4.27] subset: gosubset_prok synonym: "5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)" EXACT [EC:3.5.4.27] synonym: "5,10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "methenyl-H(4)MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "methenyl-H4MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] xref: EC:3.5.4.27 xref: GO:0018759 xref: MetaCyc:3.5.4.27-RXN xref: UM-BBD_enzymeID:e0140 is_a: CCO:F0004139 ! cyclohydrolase activity [Term] id: CCO:F0003947 name: thiocyanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: thiocyanate + H2O = NH3 + carbonyl sulfide." [UM-BBD_enzymeID:e0399] synonym: "thiocyanate aminohydrolase activity" EXACT [EC:3.5.5.8] xref: EC:3.5.5.8 xref: GO:0018760 xref: MetaCyc:RXN-1761 xref: UM-BBD_enzymeID:e0399 is_a: CCO:F0003384 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: CCO:F0003948 name: bromoxynil nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxy-benzoate + NH3. Involved in the bacterial degradation of the herbicide bromoxynil." [EC:3.5.5.6] subset: gosubset_prok synonym: "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity" EXACT [] synonym: "bromoxynil-specific nitrilase activity" EXACT [] xref: EC:3.5.5.6 xref: GO:0018761 xref: MetaCyc:3.5.5.6-RXN xref: UM-BBD_enzymeID:e0357 is_a: CCO:F0000053 ! nitrilase activity [Term] id: CCO:F0003949 name: aliphatic nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7] subset: gosubset_prok synonym: "aliphatic nitrile aminohydrolase activity" EXACT [EC:3.5.5.7] xref: EC:3.5.5.7 xref: GO:0018762 xref: MetaCyc:3.5.5.7-RXN xref: UM-BBD_enzymeID:e0413 is_a: CCO:F0000053 ! nitrilase activity [Term] id: CCO:F0003950 name: hydroxydechloroatrazine ethylaminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.99.3] subset: gosubset_prok synonym: "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity" EXACT [EC:3.5.99.3] synonym: "AtzB" RELATED [EC:3.5.99.3] synonym: "hydroxyatrazine ethylaminohydrolase activity" EXACT [] synonym: "hydroxyatrazine hydrolase activity" EXACT [EC:3.5.99.3] xref: EC:3.5.99.3 xref: GO:0018763 xref: MetaCyc:R122-RXN xref: UM-BBD_enzymeID:e0085 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0003951 name: N-isopropylammelide isopropylaminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.99.4] subset: gosubset_prok synonym: "AtzC" RELATED [EC:3.5.99.4] xref: EC:3.5.99.4 xref: GO:0018764 xref: MetaCyc:R123-RXN xref: UM-BBD_enzymeID:e0086 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0003952 name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_enzymeID:e0223] xref: EC:3.7.1.- xref: GO:0018765 xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN xref: UM-BBD_enzymeID:e0223 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003953 name: dihydrophloroglucinol hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_enzymeID:e0011] xref: EC:3.7.1.- xref: GO:0018766 xref: MetaCyc:R6-RXN xref: UM-BBD_enzymeID:e0011 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003954 name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [UM-BBD_enzymeID:e0102] xref: EC:3.7.1.- xref: GO:0018767 xref: UM-BBD_enzymeID:e0102 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003955 name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoat + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_enzymeID:e0325] xref: EC:3.7.1.- xref: GO:0018768 xref: UM-BBD_enzymeID:e0325 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003956 name: 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_enzymeID:e0221] xref: EC:3.7.1.- xref: GO:0018769 xref: UM-BBD_enzymeID:e0221 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003957 name: 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate + H2O = 2-(4-chlorophenyl)-3,3-dichloropropenoate." [UM-BBD_enzymeID:e0314] xref: EC:3.7.1.- xref: GO:0018770 xref: UM-BBD_enzymeID:e0314 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003958 name: 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-keto-nona-2,4-dienedioate + OH- = cis-2-hydroxypenta-2,4-dienoate + succinate." [UM-BBD_enzymeID:e0310] xref: EC:3.7.1.- xref: GO:0008680 xref: GO:0018771 xref: UM-BBD_enzymeID:e0310 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003959 name: trioxoheptanoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_enzymeID:e0075] xref: EC:3.7.1.- xref: GO:0018772 xref: MetaCyc:R306-RXN xref: UM-BBD_enzymeID:e0075 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003960 name: acetylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetylpyruvate + H2O = acetate + pyruvate." [EC:3.7.1.6] synonym: "2,4-dioxopentanoate acetylhydrolase activity" EXACT [EC:3.7.1.6] xref: EC:3.7.1.6 xref: GO:0018773 xref: MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN xref: UM-BBD_enzymeID:e0076 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003961 name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate." [EC:3.7.1.8] subset: gosubset_prok synonym: "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity" EXACT [EC:3.7.1.8] synonym: "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity" EXACT [] synonym: "HOHPDA hydrolase activity" EXACT [EC:3.7.1.8] xref: EC:3.7.1.8 xref: GO:0018774 xref: MetaCyc:3.7.1.8-RXN xref: UM-BBD_enzymeID:e0033 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003962 name: 2-hydroxymuconate-semialdehyde hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate." [EC:3.7.1.9] synonym: "2-hydroxymuconate-semialdehyde formylhydrolase activity" EXACT [EC:3.7.1.9] synonym: "2-hydroxymuconic semialdehyde hydrolase activity" EXACT [EC:3.7.1.9] synonym: "HMSH" RELATED [EC:3.7.1.9] synonym: "HOD hydrolase activity" EXACT [EC:3.7.1.9] xref: EC:3.7.1.9 xref: GO:0018775 xref: MetaCyc:3.7.1.9-RXN xref: UM-BBD_enzymeID:e0139 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0003963 name: trans-chloroacrylic acid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [UM-BBD_enzymeID:e0434] xref: EC:3.8.1.- xref: GO:0018776 xref: UM-BBD_enzymeID:e0434 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003964 name: 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214] xref: EC:3.8.1.- xref: GO:0018777 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003965 name: DL-2 haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [UM-BBD_enzymeID:e0269] xref: EC:3.8.1.- xref: GO:0018778 xref: UM-BBD_enzymeID:e0269 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003966 name: 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity namespace: molecular_function xref: EC:3.8.1.- xref: GO:0018779 xref: UM-BBD_enzymeID:e0100 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003967 name: dichloroacetate halidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate." [UM-BBD_enzymeID:e0268] xref: EC:3.8.1.- xref: GO:0018780 xref: UM-BBD_enzymeID:e0268 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003968 name: S-triazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine -> 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330] xref: EC:3.8.1.- xref: GO:0018781 xref: UM-BBD_enzymeID:e0091 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003969 name: cis-chloroacrylic acid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [UM-BBD_enzymeID:e0433] xref: EC:3.8.1.- xref: GO:0018782 xref: UM-BBD_enzymeID:e0433 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003970 name: deisopropyldeethylatrazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [UM-BBD_reactionID:0129] xref: EC:3.8.1.- xref: GO:0018783 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003972 name: haloacetate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: haloacetate + H2O = glycolate + halide." [EC:3.8.1.3] subset: gosubset_prok synonym: "haloacetate halidohydrolase activity" EXACT [EC:3.8.1.3] synonym: "monohaloacetate dehalogenase activity" EXACT [EC:3.8.1.3] xref: EC:3.8.1.3 xref: GO:0018785 xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN xref: UM-BBD_enzymeID:e0006 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003973 name: haloalkane dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide." [EC:3.8.1.5] subset: gosubset_prok synonym: "1-chlorohexane halidohydrolase activity" EXACT [EC:3.8.1.5] synonym: "1-haloalkane dehalogenase activity" EXACT [EC:3.8.1.5] synonym: "1-haloalkane halidohydrolase activity" EXACT [EC:3.8.1.5] xref: EC:3.8.1.5 xref: GO:0018786 xref: MetaCyc:HALOALKANE-DEHALOGENASE-RXN xref: UM-BBD_enzymeID:e0003 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003974 name: 4-chlorobenzoyl-CoA dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride." [EC:3.8.1.7] synonym: "4-chlorobenzoyl CoA chlorohydrolase activity" EXACT [EC:3.8.1.7] xref: EC:3.8.1.7 xref: GO:0018787 xref: MetaCyc:3.8.1.7-RXN xref: UM-BBD_enzymeID:e0113 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003975 name: atrazine chlorohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride." [EC:3.8.1.8] subset: gosubset_prok synonym: "AtzA" RELATED [EC:3.8.1.8] xref: EC:3.8.1.8 xref: GO:0018788 xref: MetaCyc:3.8.1.8-RXN xref: UM-BBD_enzymeID:e0001 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0003976 name: cyclamate sulfohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + SO4(2-) (sulfate)." [EC:3.10.1.2] synonym: "cyclamate sulfamatase activity" EXACT [] synonym: "cyclamate sulfamidase activity" EXACT [EC:3.10.1.2] synonym: "cyclamate sulphohydrolase activity" EXACT [] synonym: "cyclohexylsulfamate sulfamidase activity" EXACT [EC:3.10.1.2] synonym: "cyclohexylsulfamate sulfohydrolase activity" EXACT [EC:3.10.1.2] xref: EC:3.10.1.2 xref: GO:0018789 xref: MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN xref: UM-BBD_enzymeID:e0478 is_a: CCO:F0003393 ! hydrolase activity, acting on acid sulfur-nitrogen bonds [Term] id: CCO:F0003977 name: 2,3-dihydroxybenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = CO2 + catechol." [UM-BBD_enzymeID:e0383] xref: EC:4.1.1.- xref: GO:0018790 xref: UM-BBD_enzymeID:e0383 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003978 name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [UM-BBD_enzymeID:e0286] xref: EC:4.1.1.- xref: GO:0018791 xref: UM-BBD_enzymeID:e0286 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003979 name: bis(4-chlorophenyl)acetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [UM-BBD_enzymeID:e0355] synonym: "DDA decarboxylase activity" EXACT [] xref: EC:4.1.1.- xref: GO:0018792 xref: UM-BBD_enzymeID:e0355 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003980 name: 3,5-dibromo-4-hydroxybenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [UM-BBD_enzymeID:e0358] xref: EC:4.1.1.- xref: GO:0018793 xref: UM-BBD_enzymeID:e0358 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003981 name: 2-hydroxyisobutyrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [UM-BBD_enzymeID:e0408] xref: EC:4.1.1.- xref: GO:0018794 xref: UM-BBD_enzymeID:e0408 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003982 name: 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [UM-BBD_enzymeID:e0412] xref: EC:4.1.1.- xref: GO:0018795 xref: UM-BBD_enzymeID:e0412 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003983 name: 4,5-dihydroxyphthalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.55] subset: gosubset_prok synonym: "4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.55] synonym: "4,5-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.55] xref: EC:4.1.1.55 xref: GO:0018796 xref: MetaCyc:4 xref: UM-BBD_enzymeID:e0106 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003984 name: gallate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4,5-trihydroxybenzoate = pyrogallol + CO2." [EC:4.1.1.59] synonym: "gallate carboxy-lyase (pyrogallol-forming)" EXACT [EC:4.1.1.59] synonym: "gallate carboxy-lyase activity" EXACT [EC:4.1.1.59] synonym: "gallic acid decarboxylase activity" EXACT [] xref: EC:4.1.1.59 xref: GO:0018798 xref: MetaCyc:GALLATE-DECARBOXYLASE-RXN xref: UM-BBD_enzymeID:e0008 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003985 name: 4-hydroxybenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate = phenol + CO2." [EC:4.1.1.61] subset: gosubset_prok synonym: "4-hydroxybenzoate carboxy-lyase (phenol-forming)" EXACT [EC:4.1.1.61] synonym: "4-hydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.61] synonym: "p-hydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.61] xref: EC:4.1.1.61 xref: GO:0018799 xref: MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN xref: UM-BBD_enzymeID:e0138 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003986 name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68, UniProt:Q46978] subset: gosubset_prok synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity" EXACT [EC:4.1.1.68] synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity" EXACT [] synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)" EXACT [EC:4.1.1.68] synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.68] synonym: "HpaG-2" RELATED [] synonym: "HpaG2" RELATED [] synonym: "OPET decarboxylase activity" EXACT [] xref: EC:4.1.1.68 xref: GO:0018800 xref: MetaCyc:4.1.1.68-RXN xref: UM-BBD_enzymeID:e0137 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003987 name: glutaconyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: pent-2-enoyl-CoA = but-2-enoyl-CoA + CO2." [EC:4.1.1.70] subset: gosubset_prok synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)" EXACT [EC:4.1.1.70] synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70] synonym: "glutaconyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.70] synonym: "pent-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70] xref: EC:4.1.1.70 xref: GO:0018801 xref: MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN xref: UM-BBD_enzymeID:e0136 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003988 name: 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [UM-BBD_enzymeID:e0282] xref: EC:4.1.2.- xref: GO:0018802 xref: UM-BBD_enzymeID:e0282 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003989 name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34] synonym: "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.34] synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] synonym: "2'-carboxybenzalpyruvate aldolase activity" EXACT [EC:4.1.2.34] synonym: "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity" EXACT [] xref: EC:4.1.2.34 xref: GO:0018803 xref: MetaCyc:4.1.2.34-RXN xref: UM-BBD_enzymeID:e0330 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0003990 name: benzylsuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: fumarate + toluene = benzylsuccinate." [UM-BBD_enzymeID:e0259] synonym: "benzylsuccinate fumarate-lyase (toluene-forming)" EXACT [EC:4.1.99.11] synonym: "benzylsuccinate fumarate-lyase activity" EXACT [EC:4.1.99.11] xref: EC:4.1.99.11 xref: GO:0018805 xref: MetaCyc:RXN-863 xref: UM-BBD_enzymeID:e0259 is_a: CCO:F0003397 ! carbon-carbon lyase activity [Term] id: CCO:F0003991 name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_enzymeID:e0185] xref: EC:4.2.1.- xref: GO:0018807 xref: UM-BBD_enzymeID:e0185 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003992 name: cis-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [UM-BBD_enzymeID:e0327] xref: EC:4.2.1.- xref: GO:0018808 xref: UM-BBD_enzymeID:e0327 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003993 name: E-phenylitaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [UM-BBD_enzymeID:e0262] xref: EC:4.2.1.- xref: GO:0018809 xref: UM-BBD_enzymeID:e0262 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003994 name: trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [UM-BBD_enzymeID:e0164] xref: EC:4.2.1.- xref: GO:0018810 xref: UM-BBD_enzymeID:e0164 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003995 name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_enzymeID:e0175] xref: EC:4.2.1.- xref: GO:0018811 xref: MetaCyc:R266-RXN xref: UM-BBD_enzymeID:e0175 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003996 name: 3-hydroxyacyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA)." [UM-BBD_ruleID:bt0291] xref: EC:4.2.1.- xref: GO:0018812 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003997 name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E )-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:e0257] xref: EC:4.2.1.- xref: GO:0018813 xref: UM-BBD_enzymeID:e0257 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0003998 name: phenylacetaldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (Z)-phenylacetaldehyde oxime = phenylacetonitrile + H2O." [EC:4.99.1.7, UM-BBD_enzymeID:e0437] synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity" EXACT [EC:4.99.1.7] synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.7] synonym: "arylacetaldoxime dehydratase activity" EXACT [EC:4.99.1.7] synonym: "OxdB" RELATED [EC:4.99.1.7] synonym: "PAOx dehydratase activity" EXACT [EC:4.99.1.7] xref: EC:4.99.1.7 xref: GO:0018814 xref: UM-BBD_enzymeID:e0437 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0003999 name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = CH2CHCOCOOH + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_enzymeID:e0045] xref: EC:4.2.1.- xref: GO:0018815 xref: MetaCyc:RXN-645 xref: UM-BBD_enzymeID:e0045 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004000 name: 2-hydroxyisobutyrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate." [UM-BBD_enzymeID:e0409] xref: EC:4.2.1.- xref: GO:0018816 xref: UM-BBD_enzymeID:e0409 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004001 name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_enzymeID:e0281] subset: gosubset_prok synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT [] synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT [] synonym: "HpaH" RELATED [] xref: EC:4.2.1.- xref: GO:0018817 xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN xref: UM-BBD_enzymeID:e0281 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004002 name: acetylene hydratase activity namespace: molecular_function def: "Catalysis of the reaction: acetaldehyde = acetylene + H2O." [EC:4.2.1.112, UM-BBD_enzymeID:e0394] synonym: "acetaldehyde hydro-lyase activity" EXACT [EC:4.2.1.112] synonym: "AH" RELATED [EC:4.2.1.112] synonym: "AHy" RELATED [EC:4.2.1.112] xref: EC:4.2.1.112 xref: GO:0018818 xref: UM-BBD_enzymeID:e0394 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004003 name: lactoyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O." [EC:4.2.1.54] synonym: "acrylyl coenzyme A hydratase activity" EXACT [EC:4.2.1.54] synonym: "lactoyl coenzyme A dehydratase activity" EXACT [EC:4.2.1.54] synonym: "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)" EXACT [EC:4.2.1.54] synonym: "lactoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.54] synonym: "lactyl CoA dehydratase activity" EXACT [EC:4.2.1.54] synonym: "lactyl-coenzyme A dehydrase activity" EXACT [EC:4.2.1.54] xref: EC:4.2.1.54 xref: GO:0018819 xref: MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN xref: MetaCyc:RXN-781 xref: UM-BBD_enzymeID:e0070 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004004 name: cyanamide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: urea = cyanamide + H2O." [EC:4.2.1.69] synonym: "urea hydro-lyase (cyanamide-forming)" EXACT [EC:4.2.1.69] synonym: "urea hydro-lyase activity" EXACT [EC:4.2.1.69] xref: EC:4.2.1.69 xref: GO:0018820 xref: MetaCyc:CYANAMIDE-HYDRATASE-RXN xref: UM-BBD_enzymeID:e0426 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004005 name: nitrile hydratase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O." [EC:4.2.1.84] subset: gosubset_prok synonym: "3-cyanopyridine hydratase activity" EXACT [EC:4.2.1.84] synonym: "acrylonitrile hydratase activity" EXACT [EC:4.2.1.84] synonym: "aliphatic nitrile hydratase activity" EXACT [EC:4.2.1.84] synonym: "aliphatic-amide hydro-lyase (nitrile-forming)" EXACT [EC:4.2.1.84] synonym: "H-NHase activity" EXACT [EC:4.2.1.84] synonym: "L-NHase activity" EXACT [EC:4.2.1.84] synonym: "NHase activity" EXACT [EC:4.2.1.84] synonym: "nitrile hydro-lyase activity" EXACT [EC:4.2.1.84] xref: EC:4.2.1.84 xref: GO:0018822 xref: MetaCyc:NITRILE-HYDRATASE-RXN xref: UM-BBD_enzymeID:e0067 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004006 name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohex-1,5-dienecarbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA." [EC:4.2.1.100] subset: gosubset_prok synonym: "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)" RELATED [EC:4.2.1.100] synonym: "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [] synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [EC:4.2.1.100] synonym: "cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity" EXACT [EC:4.2.1.100] synonym: "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.100] synonym: "dienoyl-CoA hydratase activity" EXACT [EC:4.2.1.100] xref: EC:4.2.1.100 xref: GO:0018823 xref: MetaCyc:4.2.1.100-RXN xref: UM-BBD_enzymeID:e0184 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004008 name: triethanolamine lyase activity namespace: molecular_function def: "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [UM-BBD_enzymeID:e0421] xref: EC:4.3.3.- xref: GO:0018825 xref: UM-BBD_enzymeID:e0421 is_a: CCO:F0003408 ! amine-lyase activity [Term] id: CCO:F0004009 name: methionine gamma-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate." [EC:4.4.1.11] subset: gosubset_prok synonym: "L-methioninase activity" EXACT [EC:4.4.1.11] synonym: "L-methionine gamma-lyase activity" EXACT [EC:4.4.1.11] synonym: "L-methionine methanethiol-lyase (deaminating)" EXACT [EC:4.4.1.11] synonym: "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.11] synonym: "methioninase activity" EXACT [EC:4.4.1.11] synonym: "methionine dethiomethylase activity" EXACT [EC:4.4.1.11] synonym: "methionine lyase activity" EXACT [EC:4.4.1.11] xref: EC:4.4.1.11 xref: GO:0018826 xref: MetaCyc:METHIONINE-GAMMA-LYASE-RXN xref: UM-BBD_enzymeID:e0305 is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0004010 name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_enzymeID:e0353] synonym: "DDMS dehydrochlorinase activity" EXACT [] xref: EC:4.5.1.- xref: GO:0018827 xref: UM-BBD_enzymeID:e0353 is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0004011 name: halohydrin hydrogen-halide-lyase A activity namespace: molecular_function def: "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0048] xref: EC:4.5.1.- xref: GO:0018828 xref: UM-BBD_enzymeID:e0048 is_a: CCO:F0004114 ! halohydrin hydrogen-halide-lyase activity [Term] id: CCO:F0004012 name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_enzymeID:e0351] synonym: "DDD dehydrochlorinase activity" EXACT [] xref: EC:4.5.1.- xref: GO:0018829 xref: UM-BBD_enzymeID:e0351 is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0004013 name: gamma-hexachlorocyclohexane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359] xref: EC:4.5.1.- xref: GO:0018830 xref: UM-BBD_enzymeID:e0359 is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0004014 name: 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_enzymeID:e0425] xref: EC:4.5.1.- xref: GO:0018831 xref: UM-BBD_enzymeID:e0425 is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0004015 name: halohydrin hydrogen-halide-lyase B activity namespace: molecular_function def: "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0050] xref: EC:4.5.1.- xref: GO:0018832 xref: UM-BBD_enzymeID:e0050 is_a: CCO:F0004114 ! halohydrin hydrogen-halide-lyase activity [Term] id: CCO:F0004016 name: DDT-dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + chloride." [EC:4.5.1.1] synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]" RELATED [EC:4.5.1.1] synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity" EXACT [EC:4.5.1.1] synonym: "DDT dehydrochlorinase activity" EXACT [] synonym: "DDT-as" RELATED [EC:4.5.1.1] synonym: "DDT-ase activity" EXACT [EC:4.5.1.1] synonym: "DDTase activity" EXACT [EC:4.5.1.1] xref: EC:4.5.1.1 xref: GO:0018833 xref: MetaCyc:DDT-DEHYDROCHLORINASE-RXN xref: UM-BBD_enzymeID:e0311 is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0004017 name: dichloromethane dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: dichloromethane + H2O = formaldehyde + 2 chloride." [EC:4.5.1.3] subset: gosubset_prok synonym: "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)" EXACT [EC:4.5.1.3] synonym: "dichloromethane chloride-lyase (chloride-hydrolysing)" EXACT [EC:4.5.1.3] xref: EC:4.5.1.3 xref: GO:0018834 xref: MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN xref: UM-BBD_enzymeID:e0174 is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0004018 name: carbon phosphorus lyase activity namespace: molecular_function def: "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [UM-BBD_enzymeID:e0057] xref: EC:4.99.1.- xref: GO:0009456 xref: GO:0018835 xref: UM-BBD_enzymeID:e0057 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0004019 name: alkylmercury lyase activity namespace: molecular_function def: "Catalysis of the reaction: R-Hg+ + H+ = R-H + Hg2+." [EC:4.99.1.2] subset: gosubset_prok synonym: "alkylmercury mercuric-lyase (alkane-forming)" EXACT [EC:4.99.1.2] synonym: "alkylmercury mercuric-lyase activity" EXACT [EC:4.99.1.2] synonym: "organomercurial lyase activity" EXACT [EC:4.99.1.2] synonym: "organomercury lyase activity" EXACT [EC:4.99.1.2] xref: EC:4.99.1.2 xref: GO:0018836 xref: MetaCyc:ALKYLMERCURY-LYASE-RXN xref: UM-BBD_enzymeID:e0055 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0004020 name: 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [UM-BBD_enzymeID:e0344] xref: EC:5.1.2.- xref: GO:0018837 xref: UM-BBD_enzymeID:e0344 is_a: CCO:F0003419 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: CCO:F0004021 name: mandelate racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-mandelate = (R)-mandelate." [EC:5.1.2.2] subset: gosubset_prok xref: EC:5.1.2.2 xref: GO:0018838 xref: MetaCyc:MANDELATE-RACEMASE-RXN xref: UM-BBD_enzymeID:e0072 is_a: CCO:F0003419 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: CCO:F0004022 name: cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_enzymeID:e0163] xref: EC:5.2.1.- xref: GO:0018839 xref: UM-BBD_enzymeID:e0163 is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0004023 name: 3-carboxymuconate cycloisomerase type II activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfomuconate = 4-sulfolactone." [UM-BBD_enzymeID:e0379] subset: gosubset_prok xref: EC:5.3.3.- xref: GO:0018842 xref: UM-BBD_enzymeID:e0379 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0004024 name: 2-hydroxytetrahydrofuran isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_enzymeID:e0026] xref: EC:5.3.99.- xref: GO:0018844 xref: UM-BBD_enzymeID:e0026 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0004025 name: 2-hydroxychromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = trans-o-hydroxybenzylidenepyruvate." [UM-BBD_enzymeID:e0258] xref: EC:5.3.99.- xref: GO:0018845 xref: UM-BBD_enzymeID:e0258 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0004026 name: styrene-oxide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: styrene oxide = phenylacetaldehyde." [EC:5.3.99.7] synonym: "SOI activity" EXACT [EC:5.3.99.7] synonym: "styrene oxide isomerase activity" EXACT [] synonym: "styrene-oxide isomerase (epoxide-cleaving)" EXACT [EC:5.3.99.7] xref: EC:5.3.99.7 xref: GO:0018846 xref: MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN xref: UM-BBD_enzymeID:e0196 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0004027 name: alpha-pinene lyase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene = limonene." [UM-BBD_enzymeID:e0442] xref: EC:5.5.1.- xref: GO:0018847 xref: UM-BBD_enzymeID:e0442 is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0004028 name: pinocarveol isomerase activity namespace: molecular_function def: "Catalysis of the reaction: pinocarveol = carveol." [UM-BBD_enzymeID:e0447] xref: EC:5.5.1.- xref: GO:0018848 xref: UM-BBD_enzymeID:e0447 is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0004029 name: muconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [EC:5.5.1.1] subset: gosubset_prok synonym: "2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.1] synonym: "4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing)" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate cycloisomerase activity" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate lactonizing enzyme I activity" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate-lactonizing enzyme" RELATED [EC:5.5.1.1] synonym: "muconate cycloisomerase I activity" EXACT [EC:5.5.1.1] synonym: "muconate lactonizing enzyme activity" EXACT [EC:5.5.1.1] xref: EC:5.5.1.1 xref: GO:0018849 xref: MetaCyc:MUCONATE-CYCLOISOMERASE-RXN xref: UM-BBD_enzymeID:e0133 is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0004030 name: chloromuconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7] subset: gosubset_prok synonym: "2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.7] synonym: "muconate cycloisomerase II activity" EXACT [EC:5.5.1.7] xref: EC:5.5.1.7 xref: GO:0018850 xref: MetaCyc:CHLOROMUCONATE-CYCLOISOMERASE-RXN xref: UM-BBD_enzymeID:e0065 is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0004031 name: alpha-pinene-oxide decyclase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10] synonym: "alpha-pinene oxide lyase activity" EXACT [] synonym: "alpha-pinene-oxide lyase (decyclizing)" EXACT [EC:5.5.1.10] xref: EC:5.5.1.10 xref: GO:0018851 xref: MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN xref: UM-BBD_enzymeID:e0471 is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0004032 name: dichloromuconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11] synonym: "2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.11] xref: EC:5.5.1.11 xref: GO:0018852 xref: MetaCyc:DICHLOROMUCONATE-CYCLOISOMERASE-RXN xref: UM-BBD_enzymeID:e0132 is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0004033 name: perillyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_enzymeID:e0460] xref: EC:6.2.1.- xref: GO:0018853 xref: UM-BBD_enzymeID:e0460 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004034 name: 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [UM-BBD_enzymeID:e0465] xref: EC:6.2.1.- xref: GO:0018854 xref: UM-BBD_enzymeID:e0465 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004035 name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_enzymeID:e0303] xref: EC:6.2.1.- xref: GO:0018855 xref: UM-BBD_enzymeID:e0303 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004036 name: benzoyl acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl acetate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_enzymeID:e0212] xref: EC:6.2.1.- xref: GO:0018856 xref: UM-BBD_enzymeID:e0212 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004037 name: 2,4-dichlorobenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [UM-BBD_enzymeID:e0110] xref: EC:6.2.1.- xref: GO:0018857 xref: UM-BBD_enzymeID:e0110 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004038 name: benzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA. Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates." [EC:6.2.1.25] subset: gosubset_prok synonym: "benzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.25] synonym: "benzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.25] synonym: "benzoyl CoA synthetase (AMP forming)" EXACT [EC:6.2.1.25] synonym: "benzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.25] xref: EC:6.2.1.25 xref: GO:0018858 xref: MetaCyc:BENZOATE--COA-LIGASE-RXN xref: UM-BBD_enzymeID:e0131 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004039 name: 4-hydroxybenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27] subset: gosubset_prok synonym: "4-hydroxybenzoate-CoA synthetase activity" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoate-coenzyme A ligase (AMP-forming)" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoyl-CoA ligase activity" EXACT [EC:6.2.1.27] xref: EC:6.2.1.27 xref: GO:0018859 xref: MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN xref: UM-BBD_enzymeID:e0130 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004040 name: anthranilate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32] subset: gosubset_prok synonym: "2-aminobenzoate coenzyme A ligase activity" EXACT [EC:6.2.1.32] synonym: "2-aminobenzoate-CoA ligase activity" EXACT [EC:6.2.1.32] synonym: "2-aminobenzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.32] synonym: "anthranilate--CoA ligase activity" EXACT [] synonym: "anthranilate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.32] synonym: "anthraniloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.32] xref: EC:6.2.1.32 xref: GO:0018860 xref: MetaCyc:AMINOBENZCOALIG-RXN xref: UM-BBD_enzymeID:e0129 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004041 name: 4-chlorobenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. Requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33] subset: gosubset_prok synonym: "4-chlorobenzoate:CoA ligase activity" EXACT [] xref: EC:6.2.1.33 xref: GO:0018861 xref: MetaCyc:6.2.1.33-RXN xref: UM-BBD_enzymeID:e0112 is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004042 name: phenylphosphate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate." [UM-BBD_enzymeID:e0158] xref: EC:6.4.1.- xref: GO:0018862 xref: UM-BBD_enzymeID:e0158 is_a: CCO:F0003443 ! ligase activity, forming carbon-carbon bonds [Term] id: CCO:F0004043 name: phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0335] xref: EC:3.3.2.- xref: GO:0018863 xref: UM-BBD_enzymeID:e0335 is_a: CCO:F0004065 ! phenanthrene-9,10-epoxide hydrolase activity [Term] id: CCO:F0004044 name: guanyl nucleotide binding namespace: molecular_function def: "Interacting selectively with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0019001 xref: Reactome:6405 is_a: CCO:F0003548 ! purine nucleotide binding [Term] id: CCO:F0004045 name: GMP binding namespace: molecular_function def: "Interacting selectively with GMP, guanosine monophosphate." [GOC:ai] xref: GO:0019002 is_a: CCO:F0005024 ! guanyl ribonucleotide binding [Term] id: CCO:F0004046 name: GDP binding namespace: molecular_function def: "Interacting selectively with GDP, guanosine 5'-diphosphate." [GOC:ai] xref: GO:0019003 is_a: CCO:F0005024 ! guanyl ribonucleotide binding [Term] id: CCO:F0004047 name: N-acetylneuraminic acid phosphate synthase activity namespace: molecular_function xref: GO:0019007 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0004048 name: farnesoic acid O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499] synonym: "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity" EXACT [] xref: GO:0019010 is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004049 name: viral antireceptor activity namespace: molecular_function xref: GO:0019041 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0004050 name: pyrimidine nucleotide binding namespace: molecular_function def: "Interacting selectively with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate." [GOC:ai] xref: GO:0019103 is_a: CCO:F0000031 ! nucleotide binding [Term] id: CCO:F0004051 name: DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. subset: gosubset_prok synonym: "DNA glycosylase activity" EXACT [] synonym: "endonuclease VIII activity" RELATED [] xref: EC:3.2.2.- xref: GO:0008578 xref: GO:0019104 xref: Reactome:7370 is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0004052 name: N-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0019105 is_a: CCO:F0003132 ! palmitoyltransferase activity is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0004053 name: myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0019107 xref: Reactome:2349 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0004054 name: aryl-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+." [EC:1.2.1.29] synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.29] xref: EC:1.2.1.29 xref: GO:0019108 xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0228 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004055 name: acyl-CoA reductase activity namespace: molecular_function subset: gosubset_prok xref: EC:1.3.99.- xref: GO:0019109 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0004056 name: oxidoreductase activity, acting on iron-sulfur proteins as donors, hydrogen ions as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces hydrogen ions." [GOC:jl] synonym: "oxidoreductase activity, acting on reduced ferredoxin as donor, hydrogen ions as acceptors" NARROW [] xref: EC:1.18.3 xref: EC:1.18.99 xref: GO:0016736 xref: GO:0019110 is_a: CCO:F0003311 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: CCO:F0004057 name: phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate." [EC:2.8.2.-] synonym: "phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0019111 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0004058 name: phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O." [GOC:ai] xref: EC:2.4.1.- xref: GO:0019112 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0004059 name: limonene monooxygenase activity namespace: molecular_function xref: EC:1.14.13.- xref: GO:0019113 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0004060 name: catechol dioxygenase activity namespace: molecular_function subset: gosubset_prok xref: EC:1.13.11.- xref: GO:0019114 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0004061 name: benzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+." [EC:1.2.1.28, EC:1.2.1.7] subset: gosubset_prok xref: EC:1.2.1.- xref: GO:0019115 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004062 name: hydroxy-nicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2." [GOC:jl, http://umbbd.ahc.umn.edu/] subset: gosubset_prok xref: EC:1.5.3.- xref: GO:0019116 is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0004063 name: dihydroxyfluorene dioxygenase activity namespace: molecular_function xref: EC:1.13.11.- xref: GO:0019117 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0004064 name: phenanthrene-epoxide hydrolase activity namespace: molecular_function xref: EC:3.3.2.- xref: GO:0019118 is_a: CCO:F0000723 ! epoxide hydrolase activity [Term] id: CCO:F0004065 name: phenanthrene-9,10-epoxide hydrolase activity namespace: molecular_function xref: EC:3.3.2.- xref: GO:0019119 is_a: CCO:F0004064 ! phenanthrene-epoxide hydrolase activity [Term] id: CCO:F0004066 name: hydrolase activity, acting on acid halide bonds, in C-halide compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.8.1 xref: GO:0019120 is_a: CCO:F0003391 ! hydrolase activity, acting on acid halide bonds [Term] id: CCO:F0004067 name: tripeptidyl-peptidase I activity namespace: molecular_function def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [EC:3.4.14.9] synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9] xref: EC:3.4.14.9 xref: GO:0019131 xref: MetaCyc:3.4.14.9-RXN is_a: CCO:F0001790 ! tripeptidyl-peptidase activity [Term] id: CCO:F0004068 name: C-terminal processing peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [EC:3.4.21.102] subset: gosubset_prok synonym: "CtpA gene product (Synechocystis sp.)" RELATED [EC:3.4.21.102] synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102] synonym: "protease Re" RELATED [EC:3.4.21.102] synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102] synonym: "Tsp protease" NARROW [EC:3.4.21.102] xref: EC:3.4.21.102 xref: GO:0019132 xref: MetaCyc:3.4.21.102-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0004069 name: choline monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O." [EC:1.14.15.7] subset: gosubset_prok synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" EXACT [EC:1.14.15.7] xref: EC:1.14.15.7 xref: GO:0019133 xref: MetaCyc:RXN1F-357 is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0004070 name: glucosamine-1-phosphate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine 1-phosphate = CoA + N-acetyl-D-glucosamine 1-phosphate." [EC:2.3.1.157] subset: gosubset_prok synonym: "acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] synonym: "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] xref: EC:2.3.1.157 xref: GO:0019134 xref: MetaCyc:2.3.1.157-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0004071 name: deoxyhypusine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29] synonym: "deoxyhypusine dioxygenase activity" EXACT [EC:1.14.99.29] synonym: "deoxyhypusine hydroxylase activity" EXACT [] synonym: "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.29] synonym: "DOHH activity" EXACT [EC:1.14.99.29] xref: EC:1.14.99.29 xref: GO:0019135 xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0004072 name: deoxynucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145] subset: gosubset_prok synonym: "ATP:deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.145] synonym: "D. melanogaster deoxynucleoside kinase activity" EXACT [EC:2.7.1.145] synonym: "Dm-dNK" RELATED [EC:2.7.1.145] synonym: "ms-dNK" RELATED [EC:2.7.1.145] synonym: "Ms-dNK activity" RELATED [EC:2.7.1.145] synonym: "multifunctional deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145] xref: EC:2.7.1.145 xref: GO:0019136 xref: MetaCyc:2.7.1.145-RXN is_a: CCO:F0004129 ! nucleoside kinase activity [Term] id: CCO:F0004073 name: thioglucosidase activity namespace: molecular_function def: "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar." [EC:3.2.1.147] synonym: "myrosinase activity" EXACT [] synonym: "sinigrase activity" EXACT [] synonym: "sinigrinase activity" EXACT [] synonym: "thioglucoside glucohydrolase activity" EXACT [] xref: EC:3.2.1.147 xref: GO:0019137 xref: MetaCyc:3.2.1.147-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0004074 name: cytokinin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor." [EC:1.5.99.12] synonym: "6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] synonym: "cytokinin oxidase activity" RELATED [] synonym: "N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.12] synonym: "N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] xref: EC:1.5.99.12 xref: GO:0019139 xref: GO:0046420 xref: MetaCyc:1.5.99.12-RXN xref: MetaCyc:PWY-2841 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0004075 name: inositol 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate." [EC:2.7.1.64] synonym: "ATP:myo-inositol 1-phosphotransferase activity" EXACT [EC:2.7.1.64] synonym: "inositol 1-kinase activity" RELATED [EC:2.7.1.64] synonym: "inositol-1-kinase (phosphorylating)" EXACT [EC:2.7.1.64] synonym: "myo-inositol 1-kinase activity" RELATED [EC:2.7.1.64] synonym: "myo-inositol 3-kinase activity" EXACT [] synonym: "myoinositol kinase activity" BROAD [EC:2.7.1.64] xref: EC:2.7.1.64 xref: GO:0019140 xref: MetaCyc:MYO-INOSITOL-1-KINASE-RXN is_a: CCO:F0000836 ! inositol or phosphatidylinositol kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0004076 name: 2-dehydropantolactone reductase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.214] synonym: "(R)-pantolactone:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.214] synonym: "2-dehydropantoyl-lactone reductase (B-specific) activity" EXACT [] synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.214] synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] xref: EC:1.1.1.214 xref: GO:0019141 xref: MetaCyc:DEHYDROPANTLACRED-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004077 name: 2-hydroxyglutarate synthase activity namespace: molecular_function def: "Catalysis of the reaction: propanoyl-CoA + H2O + glyoxylate = 2-hydroxyglutarate + CoA." [EC:2.3.3.11] comment: Note that this function was formerly EC:4.1.3.9. synonym: "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity" EXACT [EC:2.3.3.11] synonym: "2-hydroxyglutaratic synthetase activity" EXACT [EC:2.3.3.11] synonym: "2-hydroxyglutaric synthetase activity" EXACT [EC:2.3.3.11] synonym: "alpha-hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] synonym: "hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] synonym: "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)" EXACT [EC:2.3.3.11] xref: EC:2.3.3.11 xref: GO:0019142 xref: MetaCyc:HYDGLUTSYN-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0004078 name: 3-deoxy-manno-octulosonate-8-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate 8-phosphate + H2O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45] subset: gosubset_prok synonym: "3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity" EXACT [EC:3.1.3.45] xref: EC:3.1.3.45 xref: GO:0019143 xref: MetaCyc:KDO-8PPHOSPHAT-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0004079 name: ADP-sugar diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate." [EC:3.6.1.21] synonym: "adenosine diphosphosugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "ADP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "ADP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.21] synonym: "ADPsugar pyrophosphatase activity" EXACT [EC:3.6.1.21] xref: EC:3.6.1.21 xref: GO:0019144 xref: MetaCyc:ADPSUGPPHOSPHAT-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0004080 name: aminobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.2.1.19] subset: gosubset_prok synonym: "4-aminobutanal dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "4-aminobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.19] synonym: "4-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "ABAL dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "gamma-aminobutyraldehyde dehydroganase activity" EXACT [EC:1.2.1.19] xref: EC:1.2.1.19 xref: GO:0019145 xref: MetaCyc:AMINOBUTDEHYDROG-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004081 name: arabinose-5-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.13] subset: gosubset_prok synonym: "arabinose phosphate isomerase activity" EXACT [EC:5.3.1.13] synonym: "D-arabinose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.13] synonym: "D-arabinose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.13] synonym: "phosphoarabinoisomerase activity" EXACT [EC:5.3.1.13] xref: EC:5.3.1.13 xref: GO:0019146 xref: MetaCyc:DARAB5PISOM-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0004083 name: D-cysteine desulfhydrase activity namespace: molecular_function def: "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15] subset: gosubset_prok synonym: "D-cysteine lyase activity" EXACT [EC:4.4.1.15] synonym: "D-cysteine sulfide-lyase (deaminating)" EXACT [EC:4.4.1.15] synonym: "D-cysteine sulfide-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.15] xref: EC:4.4.1.15 xref: GO:0019148 xref: MetaCyc:DCYSDESULF-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0004084 name: 3-chloro-D-alanine dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3." [EC:4.5.1.2] synonym: "3-chloro-D-alanine chloride-lyase (deaminating)" EXACT [EC:4.5.1.2] synonym: "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.5.1.2] synonym: "beta-chloro-D-alanine dehydrochlorinase activity" EXACT [EC:4.5.1.2] xref: EC:4.5.1.2 xref: GO:0019149 xref: MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0004085 name: D-ribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate." [EC:2.7.1.47] subset: gosubset_prok synonym: "ATP:D-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.47] synonym: "D-ribulokinase (phosphorylating)" EXACT [EC:2.7.1.47] xref: EC:2.7.1.47 xref: GO:0019150 xref: MetaCyc:D-RIBULOKIN-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0004086 name: galactose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+." [EC:1.1.1.48] subset: gosubset_prok synonym: "beta-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] synonym: "D-galactose 1-dehydrogenase activity" EXACT [] synonym: "D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] synonym: "D-galactose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.48] synonym: "NAD-dependent D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] xref: EC:1.1.1.48 xref: GO:0019151 xref: MetaCyc:GALACTODEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004087 name: acetoin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+." [EC:1.1.1.5] subset: gosubset_prok synonym: "diacetyl reductase activity" EXACT [EC:1.1.1.5] xref: EC:1.1.1.5 xref: GO:0019152 xref: MetaCyc:ACETOINDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004088 name: protein-disulfide reductase (glutathione) activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol." [EC:1.8.4.2] subset: gosubset_prok synonym: "glutaredoxin reductase" RELATED [] synonym: "glutathione--insulin transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "glutathione-insulin transhydrogenase activity" EXACT [] synonym: "glutathione-protein disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "glutathione:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "GSH-insulin transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "insulin reductase activity" EXACT [EC:1.8.4.2] synonym: "protein disulfide reductase (glutathione)" EXACT [EC:1.8.4.2] synonym: "protein disulfide transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "protein-disulfide interchange enzyme" RELATED [EC:1.8.4.2] synonym: "protein-disulfide isomerase/oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "protein-disulphide reductase (glutathione) activity" EXACT [] synonym: "reductase, protein disulfide (glutathione)" EXACT [EC:1.8.4.2] synonym: "thiol-protein disulphide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "thiol:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] xref: EC:1.8.4.2 xref: GO:0019153 xref: MetaCyc:PRODISULFREDUCT-RXN is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0004089 name: glycolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + acceptor = glyoxylate + reduced acceptor." [EC:1.1.99.14] synonym: "glycolate oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolic acid dehydrogenase activity" EXACT [EC:1.1.99.14] xref: EC:1.1.99.14 xref: GO:0019154 xref: MetaCyc:GLYCOLATEDEHYDRO-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0004090 name: 3-(imidazol-5-yl)lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+." [EC:1.1.1.111] synonym: "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.111] synonym: "imidazol-5-yl lactate dehydrogenase activity" EXACT [EC:1.1.1.111] xref: EC:1.1.1.111 xref: GO:0019155 xref: MetaCyc:IMILACTDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004091 name: isoamylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins." [EC:3.2.1.68] subset: gosubset_prok synonym: "debranching enzyme activity" BROAD [EC:3.2.1.68] synonym: "glycogen alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.68] xref: EC:3.2.1.68 xref: GO:0019156 xref: MetaCyc:3.2.1.68-RXN is_a: CCO:F0000604 ! glycogen debranching enzyme activity is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0004092 name: malate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + O2 = oxaloacetate + H2O2." [EC:1.1.3.3] synonym: "(S)-malate:oxygen oxidoreductase activity" EXACT [EC:1.1.3.3] synonym: "FAD-dependent malate oxidase activity" EXACT [EC:1.1.3.3] synonym: "malic dehydrogenase II" RELATED [EC:1.1.3.3] synonym: "malic oxidase activity" EXACT [EC:1.1.3.3] xref: EC:1.1.3.3 xref: GO:0019157 xref: MetaCyc:MALOX-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0004093 name: mannokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7] subset: gosubset_prok synonym: "ATP:D-mannose 6-phosphotransferase activity" EXACT [EC:2.7.1.7] synonym: "D-fructose (D-mannose) kinase activity" EXACT [EC:2.7.1.7] synonym: "mannokinase (phosphorylating)" EXACT [EC:2.7.1.7] xref: EC:2.7.1.7 xref: GO:0019158 xref: MetaCyc:MANNKIN-RXN is_a: CCO:F0000807 ! hexokinase activity [Term] id: CCO:F0004094 name: nicotinamide-nucleotide amidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3." [EC:3.5.1.42] synonym: "nicotinamide mononucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] synonym: "nicotinamide mononucleotide deamidase activity" EXACT [EC:3.5.1.42] synonym: "nicotinamide-D-ribonucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] synonym: "NMN amidohydrolase" NARROW [] synonym: "NMN deamidase activity" EXACT [EC:3.5.1.42] xref: EC:3.5.1.42 xref: GO:0019159 xref: MetaCyc:NMNAMIDOHYDRO-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0004095 name: NMN nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinamide D-ribonucleotide + H2O = nicotinamide + D-ribose 5-phosphate." [EC:3.2.2.14] synonym: "nicotinamide mononucleotidase activity" EXACT [EC:3.2.2.14] synonym: "nicotinamide mononucleotide nucleosidase activity" EXACT [EC:3.2.2.14] synonym: "nicotinamide-nucleotide phosphoribohydrolase activity" EXACT [EC:3.2.2.14] synonym: "NMN glycohydrolase activity" EXACT [EC:3.2.2.14] synonym: "NMNase activity" EXACT [EC:3.2.2.14] synonym: "NMNGhase activity" EXACT [EC:3.2.2.14] xref: EC:3.2.2.14 xref: GO:0019160 xref: MetaCyc:NMNNUCLEOSID-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0004096 name: diamine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate." [EC:2.6.1.29] synonym: "amine transaminase activity" EXACT [EC:2.6.1.29] synonym: "amine-ketoacid transaminase activity" EXACT [EC:2.6.1.29] synonym: "diamine aminotransferase activity" EXACT [] synonym: "diamine-ketoglutaric transaminase activity" EXACT [EC:2.6.1.29] synonym: "diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.29] xref: EC:2.6.1.29 xref: GO:0019161 xref: MetaCyc:DIAMTRANSAM-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0004097 name: pyridoxamine-oxaloacetate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine + oxaloacetate = pyridoxal + L-aspartate." [EC:2.6.1.31] synonym: "pyridoxamine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] synonym: "pyridoxamine-oxaloacetate aminotransferase activity" EXACT [] synonym: "pyridoxamine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] xref: EC:2.6.1.31 xref: GO:0019162 xref: MetaCyc:PYROXALTRANSAM-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0004098 name: pyridoxamine-phosphate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate." [EC:2.6.1.54] synonym: "pyridoxamine 5'-phosphate transaminase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine phosphate aminotransferase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)" EXACT [EC:2.6.1.54] synonym: "pyridoxamine-phosphate aminotransferase activity" EXACT [] xref: EC:2.6.1.54 xref: GO:0019163 xref: MetaCyc:PYRDAMPTRANS-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0004099 name: pyruvate synthase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + oxidized ferredoxin = acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.1] subset: gosubset_prok synonym: "pyruvate oxidoreductase activity" EXACT [EC:1.2.7.1] synonym: "pyruvate synthetase activity" EXACT [EC:1.2.7.1] synonym: "pyruvate-ferredoxin reductase activity" EXACT [] synonym: "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.7.1] synonym: "pyruvate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] synonym: "pyruvic-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] xref: EC:1.2.7.1 xref: GO:0018696 xref: GO:0019164 xref: MetaCyc:PYRUFLAVREDUCT-RXN is_a: CCO:F0003227 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0004100 name: thiamin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamin = ADP + thiamin phosphate." [EC:2.7.1.89] synonym: "ATP:thiamin phosphotransferase activity" EXACT [EC:2.7.1.89] synonym: "ATP:thiamine phosphotransferase activity" EXACT [EC:2.7.1.89] synonym: "thiamin kinase (phosphorylating)" EXACT [EC:2.7.1.89] synonym: "thiamin phosphokinase activity" EXACT [EC:2.7.1.89] synonym: "thiamine kinase activity" EXACT [] xref: EC:2.7.1.89 xref: GO:0019165 xref: MetaCyc:THIKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0004101 name: trans-2-enoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38] synonym: "acyl-CoA:NADP+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.38] synonym: "NADPH-dependent trans-2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.38] synonym: "reductase, trans-enoyl coenzyme A" EXACT [EC:1.3.1.38] xref: EC:1.3.1.38 xref: GO:0019166 xref: MetaCyc:TRANSENOYLCOARED-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004102 name: 2-octaprenylphenol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN] xref: GO:0019168 xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0004103 name: methylglyoxal reductase (NADH-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [EC:1.1.1.78] synonym: "(R)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.78] synonym: "D-lactaldehyde dehydrogenase activity" EXACT [] synonym: "methylglyoxal reductase activity" EXACT [] xref: EC:1.1.1.78 xref: GO:0019170 xref: MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004104 name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: CH3-CHOH-CH2-[CH2]n-CO-[acyl-carrier protein] = H2O + CH3-CH-CH-[CH2]n-CO-[acyl-carrier protein]." [EC:4.2.1.-, GOC:ai] subset: gosubset_prok synonym: "3-hydroxyacyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxyacyl-ACP dehydratase activity" EXACT [] xref: EC:4.2.1.- xref: GO:0019171 xref: Reactome:76135 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004105 name: glyoxalase III activity namespace: molecular_function def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [MetaCyc:GLYOXIII-RXN] comment: Note that this term was reinstated from obsolete. xref: GO:0019172 xref: MetaCyc:GLYOXIII-RXN is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0004106 name: pyrimidine phosphatase activity namespace: molecular_function xref: GO:0019173 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0004107 name: tetrahydrothiophene 1-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor." [MetaCyc:THTOREDUCT-RXN] xref: GO:0019174 xref: MetaCyc:THTOREDUCT-RXN is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0004108 name: alpha-ribazole-5'-P phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-ribazole-5'-phosphate = alpha-ribazole + phosphate." [MetaCyc:RIBAZOLEPHOSPHAT-RXN] subset: gosubset_prok xref: EC:3.1.3.- xref: GO:0019175 xref: MetaCyc:RIBAZOLEPHOSPHAT-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0004109 name: dihydroneopterin monophosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN] synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT [] xref: EC:3.6.1.- xref: GO:0019176 xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN is_a: CCO:F0003386 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: CCO:F0004110 name: dihydroneopterin triphosphate pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN] xref: EC:3.6.1.- xref: GO:0019177 xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0004111 name: NADP phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate." [MetaCyc:NADPPHOSPHAT-RXN] xref: EC:3.1.3.- xref: GO:0019178 xref: MetaCyc:NADPPHOSPHAT-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0004112 name: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate." [EC:2.6.1.33] synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity" EXACT [] synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "TDP-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "TDP-4-oxo-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity" EXACT [EC:2.6.1.33] xref: EC:2.6.1.33 xref: GO:0019179 xref: MetaCyc:2.6.1.33-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0004113 name: dTDP-4-amino-4,6-dideoxygalactose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate." [EC:2.6.1.59] synonym: "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.59] synonym: "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] synonym: "dTDP-fucosamine aminotransferase activity" EXACT [] synonym: "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.59] synonym: "thymidine diphosphoaminodideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] xref: EC:2.6.1.59 xref: GO:0019180 xref: MetaCyc:2.6.1.59-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0004114 name: halohydrin hydrogen-halide-lyase activity namespace: molecular_function xref: EC:4.5.1.- xref: GO:0019181 is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0004115 name: histamine-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0019182 is_a: CCO:F0001522 ! chloride channel activity is_a: CCO:F0002733 ! ligand-gated ion channel activity [Term] id: CCO:F0004116 name: acyl-CoA N-acyltransferase activity namespace: molecular_function xref: EC:2.3.1.- xref: GO:0019186 is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0004117 name: beta-1,4-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an beta-1,4-linkage." [GOC:mcc, PMID:8166646] xref: EC:2.4.1.- xref: GO:0019187 is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0004118 name: cellobiose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cellobiose from one side of the membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "cellobiose permease activity" EXACT [] xref: GO:0019190 xref: GO:0019191 is_a: CCO:F0002631 ! disaccharide transmembrane transporter activity [Term] id: CCO:F0004119 name: sorbose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sorbose from one side of the membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sorbose porter activity" EXACT [] xref: GO:0019193 xref: GO:0019194 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0004120 name: galactosamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of galactosamine from one side of the membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] synonym: "galactosamine porter activity" EXACT [] xref: GO:0019195 xref: GO:0019196 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0004121 name: transmembrane receptor protein phosphatase activity namespace: molecular_function def: "The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal-dependent manner." [GOC:hjd] xref: EC:3.1.3.- xref: GO:0019198 is_a: CCO:F0001086 ! phosphoprotein phosphatase activity is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0004122 name: transmembrane receptor protein kinase activity namespace: molecular_function subset: gosubset_prok xref: EC:2.7.11.- xref: GO:0019199 is_a: CCO:F0001043 ! protein kinase activity is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0004123 name: carbohydrate kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl] subset: gosubset_prok xref: GO:0019200 is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0004124 name: nucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0019201 is_a: CCO:F0004128 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: CCO:F0004125 name: amino acid kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl] subset: gosubset_prok xref: GO:0019202 is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0004126 name: carbohydrate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah] subset: gosubset_prok xref: GO:0019203 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0004127 name: nucleotide phosphatase activity namespace: molecular_function xref: GO:0019204 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0004128 name: nucleobase, nucleoside, nucleotide kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] subset: gosubset_prok xref: GO:0019205 is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0004129 name: nucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [GOC:ai] subset: gosubset_prok xref: GO:0019206 xref: Reactome:6991 is_a: CCO:F0004128 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: CCO:F0004130 name: kinase regulator activity namespace: molecular_function def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] subset: gosubset_prok xref: GO:0019207 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0004131 name: phosphatase regulator activity namespace: molecular_function def: "Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] xref: GO:0019208 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0004132 name: kinase activator activity namespace: molecular_function def: "Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] subset: gosubset_prok xref: GO:0019209 is_a: CCO:F0001691 ! enzyme activator activity is_a: CCO:F0004130 ! kinase regulator activity [Term] id: CCO:F0004133 name: kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] subset: gosubset_prok xref: GO:0019210 is_a: CCO:F0001213 ! enzyme inhibitor activity is_a: CCO:F0004130 ! kinase regulator activity [Term] id: CCO:F0004134 name: phosphatase activator activity namespace: molecular_function def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] xref: GO:0019211 is_a: CCO:F0001691 ! enzyme activator activity is_a: CCO:F0004205 ! protein phosphatase regulator activity [Term] id: CCO:F0004135 name: phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] xref: GO:0019212 is_a: CCO:F0001213 ! enzyme inhibitor activity is_a: CCO:F0004205 ! protein phosphatase regulator activity [Term] id: CCO:F0004136 name: deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl] subset: goslim_pir subset: gosubset_prok xref: GO:0019213 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0004137 name: intermediate filament binding namespace: molecular_function def: "Interacting selectively with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0019215 is_a: CCO:F0004983 ! protein complex binding [Term] id: CCO:F0004138 name: centromeric DNA binding namespace: molecular_function def: "Interacting selectively with centromere-associated DNA, usually characterized by highly repetitive sequences." [GOC:jl, ISBN:0321000382] synonym: "centromere binding" BROAD [] xref: GO:0019237 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0004139 name: cyclohydrolase activity namespace: molecular_function subset: gosubset_prok xref: GO:0019238 is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: CCO:F0004140 name: deaminase activity namespace: molecular_function def: "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: goslim_pir subset: gosubset_prok xref: GO:0019239 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0004141 name: oxalate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oxalic acid transporter" EXACT [] xref: GO:0019531 is_a: CCO:F0001551 ! dicarboxylic acid transmembrane transporter activity [Term] id: CCO:F0004142 name: toxin transporter activity namespace: molecular_function def: "Enables the directed movement of a toxin into, out of, within or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0019534 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0004143 name: ferric-vibriobactin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric-vibriobactin ions from one side of a membrane to the other." [GOC:ai] xref: GO:0019535 is_a: CCO:F0002777 ! siderophore-iron transmembrane transporter activity [Term] id: CCO:F0004144 name: protein-arginine N5-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues." [PMID:9873020] xref: EC:2.1.1.- xref: GO:0019702 is_a: CCO:F0003095 ! arginine N-methyltransferase activity [Term] id: CCO:F0004145 name: protein-cysteine S-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an myristoyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0019705 is_a: CCO:F0004053 ! myristoyltransferase activity is_a: CCO:F0004147 ! protein-cysteine S-acyltransferase activity [Term] id: CCO:F0004146 name: protein-cysteine S-palmitoleyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an palmitoleyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0019706 is_a: CCO:F0003132 ! palmitoyltransferase activity is_a: CCO:F0004147 ! protein-cysteine S-acyltransferase activity [Term] id: CCO:F0004147 name: protein-cysteine S-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] xref: EC:2.3.1.- xref: GO:0019707 is_a: CCO:F0003140 ! S-acyltransferase activity [Term] id: CCO:F0004148 name: mevaldate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + NADP+ = mevaldate + NADPH + H+." [EC:1.1.1.33] synonym: "(R)-mevalonate:NADP+ oxidoreductase" EXACT [EC:1.1.1.33] synonym: "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase" EXACT [EC:1.1.1.33] xref: EC:1.1.1.33 xref: GO:0019726 xref: MetaCyc:MEVALDATE-REDUCTASE-(NADPH)-RXN is_a: CCO:F0000892 ! mevaldate reductase activity [Term] id: CCO:F0004149 name: mevaldate reductase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + NAD+ = mevaldate + NADH + H+." [EC:1.1.1.32] xref: EC:1.1.1.32 xref: GO:0019727 xref: MetaCyc:MEVALDATE-REDUCTASE-RXN is_a: CCO:F0000892 ! mevaldate reductase activity [Term] id: CCO:F0004150 name: immunoglobulin receptor activity namespace: molecular_function def: "Combining with the Fc region of an immunoglobulin protein to initiate a change in cell activity." [ISBN:0198547684] synonym: "FC receptor activity" EXACT [] xref: GO:0016489 xref: GO:0019763 is_a: CCO:F0001240 ! transmembrane receptor activity is_a: CCO:F0004198 ! immunoglobulin binding [Term] id: CCO:F0004151 name: IgA receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of an IgA isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0019766 is_a: CCO:F0004150 ! immunoglobulin receptor activity is_a: CCO:F0004195 ! IgA binding [Term] id: CCO:F0004152 name: IgE receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0019767 is_a: CCO:F0004150 ! immunoglobulin receptor activity is_a: CCO:F0004196 ! IgE binding [Term] id: CCO:F0004153 name: high affinity IgE receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "high affinity Fc receptor activity" RELATED [] xref: GO:0019768 is_a: CCO:F0004152 ! IgE receptor activity [Term] id: CCO:F0004154 name: low affinity IgE receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "low affinity Fc receptor activity" RELATED [] xref: GO:0019769 is_a: CCO:F0004152 ! IgE receptor activity [Term] id: CCO:F0004155 name: IgG receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0019770 is_a: CCO:F0004150 ! immunoglobulin receptor activity is_a: CCO:F0004197 ! IgG binding [Term] id: CCO:F0004156 name: high affinity IgG receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "high affinity Fc receptor activity" RELATED [] xref: GO:0019771 is_a: CCO:F0004155 ! IgG receptor activity [Term] id: CCO:F0004157 name: low affinity IgG receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "low affinity Fc receptor activity" RELATED [] xref: GO:0019772 is_a: CCO:F0004155 ! IgG receptor activity [Term] id: CCO:F0004161 name: APG12 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] xref: GO:0019778 is_a: CCO:F0002013 ! small protein activating enzyme activity [Term] id: CCO:F0004162 name: APG8 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "APG7" EXACT [] xref: GO:0019779 is_a: CCO:F0002013 ! small protein activating enzyme activity [Term] id: CCO:F0004163 name: FAT10 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] xref: GO:0019780 is_a: CCO:F0002013 ! small protein activating enzyme activity [Term] id: CCO:F0004164 name: NEDD8 activating enzyme activity namespace: molecular_function def: "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924] synonym: "RUB1 activating enzyme activity" EXACT [] xref: GO:0019781 xref: GO:0019944 is_a: CCO:F0002013 ! small protein activating enzyme activity [Term] id: CCO:F0004165 name: ISG15 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "UBE1L" NARROW [] xref: GO:0019782 is_a: CCO:F0002013 ! small protein activating enzyme activity [Term] id: CCO:F0004166 name: small conjugating protein-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of various forms of polymeric ubiquitin or ubiquitin-like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin-like sequences from larger leaving groups." [GOC:ma, GOC:mah] subset: gosubset_prok synonym: "ubiquitin-like specific protease activity" NARROW [] synonym: "ubiquitin-like-protein-specific protease activity" NARROW [] xref: GO:0019783 is_a: CCO:F0001784 ! cysteine-type peptidase activity [Term] id: CCO:F0004167 name: NEDD8-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah] xref: GO:0019784 is_a: CCO:F0004166 ! small conjugating protein-specific protease activity [Term] id: CCO:F0004168 name: ISG15-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates." [GOC:mah] xref: GO:0019785 is_a: CCO:F0004166 ! small conjugating protein-specific protease activity [Term] id: CCO:F0004169 name: APG8-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah] synonym: "APG8-PE hydrolase" RELATED [] xref: GO:0019786 is_a: CCO:F0004166 ! small conjugating protein-specific protease activity [Term] id: CCO:F0004170 name: small conjugating protein ligase activity namespace: molecular_function def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] subset: gosubset_prok synonym: "E2" NARROW [] synonym: "small protein conjugating enzyme activity" EXACT [] synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like-protein ligase activity" NARROW [] xref: GO:0008639 xref: GO:0008640 xref: GO:0019787 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0004171 name: NEDD8 ligase activity namespace: molecular_function def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue." [GOC:mah] synonym: "Hub1 conjugating enzyme activity" EXACT [] synonym: "NEDD8 conjugating enzyme activity" EXACT [] synonym: "RUB1 conjugating enzyme activity" EXACT [] xref: GO:0016976 xref: GO:0019788 xref: GO:0019945 xref: GO:0042295 is_a: CCO:F0004170 ! small conjugating protein ligase activity [Term] id: CCO:F0004172 name: SUMO ligase activity namespace: molecular_function def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function." [GOC:rn, PMID:11031248, PMID:11265250] synonym: "SMT3 conjugating enzyme" EXACT [] synonym: "SUMO conjugating enzyme activity" EXACT [] xref: GO:0016930 xref: GO:0019789 xref: GO:0019949 is_a: CCO:F0004170 ! small conjugating protein ligase activity [Term] id: CCO:F0004173 name: ISG15 carrier activity namespace: molecular_function def: "Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other." [GOC:jl, http://www.copewithcytokines.de/] synonym: "interferon-stimulated gene-15 carrier activity" NARROW [] xref: GO:0019793 is_a: CCO:F0001832 ! protein transmembrane transporter activity [Term] id: CCO:F0004174 name: procollagen-proline 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7] synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.7] synonym: "procollagen-proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] synonym: "proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] synonym: "prolyl 3-hydroxylase activity" EXACT [EC:1.14.11.7] synonym: "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity" EXACT [EC:1.14.11.7] synonym: "protocollagen proline 3-hydroxylase activity" EXACT [EC:1.14.11.7] xref: EC:1.14.11.7 xref: GO:0019797 xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN is_a: CCO:F0004175 ! procollagen-proline dioxygenase activity is_a: CCO:F0004683 ! peptidyl-proline 3-dioxygenase activity [Term] id: CCO:F0004175 name: procollagen-proline dioxygenase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a collagen molecule." [EC:1.14.11.2, EC:1.14.11.7, GOC:mah] xref: EC:1.14.11.- xref: GO:0019798 is_a: CCO:F0004682 ! peptidyl-proline dioxygenase activity [Term] id: CCO:F0004176 name: tubulin N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin acetylase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "TAT activity" EXACT [EC:2.3.1.108] synonym: "tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] xref: EC:2.3.1.108 xref: GO:0019799 xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0005533 ! peptide N-acetyltransferase activity [Term] id: CCO:F0004177 name: bromide peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 R-H + 2 bromide + H2O2 = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide." [EC:1.11.1.10] subset: gosubset_prok synonym: "bromoperoxidase activity" EXACT [] xref: EC:1.11.1.- xref: GO:0019806 is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0004178 name: aspartoacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate." [EC:3.5.1.15] subset: gosubset_prok synonym: "acetyl-aspartic deaminase activity" EXACT [EC:3.5.1.15] synonym: "acylase II" RELATED [EC:3.5.1.15] synonym: "aminoacylase II activity" RELATED [EC:3.5.1.15] synonym: "N-acetylaspartate amidohydrolase activity" EXACT [EC:3.5.1.15] synonym: "N-acyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.15] xref: EC:3.5.1.15 xref: GO:0019807 xref: MetaCyc:ASPARTOACYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0004179 name: polyamine binding namespace: molecular_function def: "Interacting selectively with polyamines, organic compounds containing two or more amino groups." [GOC:ai] subset: gosubset_prok xref: GO:0019808 is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0004180 name: spermidine binding namespace: molecular_function def: "Interacting selectively with spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] xref: GO:0019809 is_a: CCO:F0004179 ! polyamine binding [Term] id: CCO:F0004181 name: putrescine binding namespace: molecular_function def: "Interacting selectively with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] xref: GO:0019810 is_a: CCO:F0004179 ! polyamine binding [Term] id: CCO:F0004182 name: cocaine binding namespace: molecular_function def: "Interacting selectively with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0019811 is_a: CCO:F0001746 ! drug binding [Term] id: CCO:F0004183 name: oxygen binding namespace: molecular_function def: "Interacting selectively with oxygen (O2)." [GOC:jl] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cytochrome P450" NARROW [] synonym: "cytochrome P450 activity" RELATED [] xref: GO:0019825 xref: Reactome:4477 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0004184 name: oxygen sensor activity namespace: molecular_function def: "Interacting selectively with and responding, e.g. by conformational change, to changes in the cellular level of, oxygen (O2)." [GOC:mah] xref: GO:0019826 is_a: CCO:F0004183 ! oxygen binding [Term] id: CCO:F0004185 name: aspartic-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." [GOC:ai] synonym: "aspartic protease inhibitor activity" EXACT [] xref: GO:0019828 is_a: CCO:F0001222 ! endopeptidase inhibitor activity [Term] id: CCO:F0004186 name: cation-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "cation ABC transporter" NARROW [] synonym: "plasma membrane cation-transporting ATPase" NARROW [] xref: GO:0019829 is_a: CCO:F0001835 ! cation transmembrane transporter activity is_a: CCO:F0005698 ! ATPase activity, coupled to transmembrane movement of ions [Term] id: CCO:F0004187 name: phospholipase A2 inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the enzyme phospholipase A2." [GOC:ai] xref: GO:0019834 is_a: CCO:F0001215 ! phospholipase inhibitor activity [Term] id: CCO:F0004188 name: growth factor binding namespace: molecular_function def: "Interacting selectively with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "neurotrophin TRK receptor activity" RELATED [] xref: GO:0019838 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004189 name: isoprenoid binding namespace: molecular_function def: "Interacting selectively with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl] subset: goslim_pir subset: gosubset_prok xref: GO:0019840 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0004190 name: retinol binding namespace: molecular_function def: "Interacting selectively with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [http://cancerweb.ncl.ac.uk/] synonym: "vitamin A1 alcohol binding" EXACT [] synonym: "vitamin A1 binding" EXACT [] xref: GO:0019841 is_a: CCO:F0001639 ! retinoid binding is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0004191 name: vitamin binding namespace: molecular_function def: "Interacting selectively with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: goslim_pir subset: gosubset_prok xref: GO:0019842 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0004192 name: rRNA binding namespace: molecular_function def: "Interacting selectively with ribosomal RNA." [GOC:jl] subset: gosubset_prok xref: GO:0019843 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0004193 name: D-tyrosyl-tRNA hydrolase activity namespace: molecular_function xref: GO:0019851 is_a: CCO:F0000521 ! aminoacyl-tRNA hydrolase activity [Term] id: CCO:F0004194 name: calcium channel inhibitor activity namespace: molecular_function def: "The inhibition of the passage of calcium ions through a calcium channel; the function of some venoms." [GOC:ma, http://haven.isb-sib.ch/spdocann//dicterms.txt, UniProtKB:kwdictionary] xref: GO:0019855 is_a: CCO:F0001514 ! calcium channel regulator activity is_a: CCO:F0001779 ! ion channel inhibitor activity [Term] id: CCO:F0004195 name: IgA binding namespace: molecular_function def: "Interacting selectively with an immunoglobulin of an IgA isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0019862 is_a: CCO:F0004198 ! immunoglobulin binding [Term] id: CCO:F0004196 name: IgE binding namespace: molecular_function def: "Interacting selectively with an immunoglobulin of the IgE isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0019863 is_a: CCO:F0004198 ! immunoglobulin binding [Term] id: CCO:F0004197 name: IgG binding namespace: molecular_function def: "Interacting selectively with an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: GO:0019864 is_a: CCO:F0004198 ! immunoglobulin binding [Term] id: CCO:F0004198 name: immunoglobulin binding namespace: molecular_function def: "Interacting selectively with an immunoglobulin." [GOC:ma] xref: GO:0019865 is_a: CCO:F0004983 ! protein complex binding [Term] id: CCO:F0004199 name: chloride channel inhibitor activity namespace: molecular_function xref: GO:0019869 is_a: CCO:F0001779 ! ion channel inhibitor activity is_a: CCO:F0003552 ! chloride channel regulator activity [Term] id: CCO:F0004200 name: potassium channel inhibitor activity namespace: molecular_function xref: GO:0019870 is_a: CCO:F0001779 ! ion channel inhibitor activity is_a: CCO:F0002867 ! potassium channel regulator activity [Term] id: CCO:F0004201 name: sodium channel inhibitor activity namespace: molecular_function xref: GO:0019868 xref: GO:0019871 is_a: CCO:F0001779 ! ion channel inhibitor activity is_a: CCO:F0003551 ! sodium channel regulator activity [Term] id: CCO:F0004202 name: 6-aminohexanoate-cyclic-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate." [EC:3.5.2.12] subset: gosubset_prok synonym: "1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity" EXACT [EC:3.5.2.12] xref: EC:3.5.2.12 xref: GO:0019874 xref: MetaCyc:3.5.2.12-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0004203 name: 6-aminohexanoate-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate." [EC:3.5.1.46] subset: gosubset_prok synonym: "6-aminohexanoic acid oligomer hydrolase activity" EXACT [EC:3.5.1.46] synonym: "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity" EXACT [EC:3.5.1.46] xref: EC:3.5.1.46 xref: GO:0019875 xref: MetaCyc:RXN-3962 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0004204 name: protein kinase regulator activity namespace: molecular_function def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] subset: gosubset_prok xref: GO:0019887 is_a: CCO:F0004130 ! kinase regulator activity [Term] id: CCO:F0004205 name: protein phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of a protein phosphatase enzyme." [GOC:ai] xref: GO:0019888 is_a: CCO:F0004131 ! phosphatase regulator activity [Term] id: CCO:F0004206 name: kinesin binding namespace: molecular_function def: "Interacting selectively and stoichiometrically with kinesin, a cytoplasmic protein responsible for moving vesicles and organelles towards the distal end of microtubules." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: GO:0019894 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0004207 name: kinesin-associated mitochondrial adaptor activity namespace: molecular_function def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria." [http://cancerweb.ncl.ac.uk/, PMID:12495622] xref: GO:0019895 is_a: CCO:F0004206 ! kinesin binding is_a: CCO:F0008241 ! molecular adaptor activity [Term] id: CCO:F0004208 name: enzyme binding namespace: molecular_function def: "Interacting selectively with any enzyme." [GOC:jl] subset: gosubset_prok xref: GO:0019899 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004209 name: kinase binding namespace: molecular_function def: "Interacting selectively with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] xref: GO:0019900 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0004210 name: protein kinase binding namespace: molecular_function def: "Interacting selectively with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] xref: GO:0019901 is_a: CCO:F0004209 ! kinase binding [Term] id: CCO:F0004211 name: phosphatase binding namespace: molecular_function def: "Interacting selectively with any phosphatase." [GOC:jl] subset: gosubset_prok xref: GO:0019902 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0004212 name: protein phosphatase binding namespace: molecular_function def: "Interacting selectively with any protein phosphatase." [GOC:jl] subset: gosubset_prok xref: GO:0019903 is_a: CCO:F0004211 ! phosphatase binding [Term] id: CCO:F0004213 name: protein domain specific binding namespace: molecular_function def: "Interacting selectively with a specific domain of a protein." [GOC:go_curators] subset: gosubset_prok synonym: "protein domain-specific binding" EXACT [] xref: GO:0019904 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004214 name: syntaxin binding namespace: molecular_function def: "Interacting selectively with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0019905 is_a: CCO:F0000027 ! SNARE binding [Term] id: CCO:F0004216 name: structural constituent of myelin sheath namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve." [GOC:mah] xref: GO:0019911 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0004217 name: cyclin-dependent protein kinase activating kinase activity namespace: molecular_function def: "Increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators] synonym: "CAK" EXACT [] synonym: "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity" EXACT [] xref: EC:2.7.11.- xref: GO:0019912 xref: GO:0019913 is_a: CCO:F0001043 ! protein kinase activity is_a: CCO:F0004382 ! protein kinase activator activity [Term] id: CCO:F0004218 name: cyclin-dependent protein kinase activating kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai] synonym: "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity" NARROW [] xref: EC:2.7.1.- xref: GO:0019914 is_a: CCO:F0004204 ! protein kinase regulator activity [Term] id: CCO:F0004219 name: SUMO activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250] synonym: "SMT3 activating enzyme" EXACT [] synonym: "SUMO E1 activator enzyme" EXACT [] xref: GO:0017115 xref: GO:0019948 is_a: CCO:F0002013 ! small protein activating enzyme activity [Term] id: CCO:F0004221 name: cytokine binding namespace: molecular_function def: "Interacting selectively with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] xref: GO:0019955 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004222 name: chemokine binding namespace: molecular_function def: "Interacting selectively with a chemokine, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [GOC:ai] xref: GO:0019956 is_a: CCO:F0004221 ! cytokine binding [Term] id: CCO:F0004223 name: C-C chemokine binding namespace: molecular_function def: "Interacting selectively with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] xref: GO:0019957 is_a: CCO:F0004222 ! chemokine binding [Term] id: CCO:F0004224 name: C-X-C chemokine binding namespace: molecular_function def: "Interacting selectively with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:ai] xref: GO:0019958 is_a: CCO:F0004222 ! chemokine binding [Term] id: CCO:F0004225 name: interleukin-8 binding namespace: molecular_function def: "Interacting selectively with interleukin-8." [GOC:jl] synonym: "IL-8 binding" EXACT [] xref: GO:0019959 is_a: CCO:F0004224 ! C-X-C chemokine binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004226 name: C-X3-C chemokine binding namespace: molecular_function def: "Interacting selectively with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] xref: GO:0019960 is_a: CCO:F0004222 ! chemokine binding [Term] id: CCO:F0004227 name: interferon binding namespace: molecular_function def: "Interacting selectively with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent." [http://en.wikipedia.org "Wikipedia"] xref: GO:0019961 is_a: CCO:F0004221 ! cytokine binding [Term] id: CCO:F0004229 name: interferon-gamma binding namespace: molecular_function def: "Interacting selectively with interferon-gamma. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383] synonym: "type II interferon binding" EXACT [] xref: GO:0019964 is_a: CCO:F0004227 ! interferon binding [Term] id: CCO:F0004230 name: interleukin binding namespace: molecular_function def: "Interacting selectively with an interleukin." [GOC:jl] synonym: "IL binding" EXACT [] xref: GO:0019965 is_a: CCO:F0004221 ! cytokine binding [Term] id: CCO:F0004231 name: interleukin-1 binding namespace: molecular_function def: "Interacting selectively with interleukin-1." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "IL-1 binding" EXACT [] xref: GO:0019966 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004232 name: interleukin-1, Type I, activating binding namespace: molecular_function synonym: "IL-1 type I, activating binding" EXACT [] xref: GO:0019967 is_a: CCO:F0004231 ! interleukin-1 binding [Term] id: CCO:F0004233 name: interleukin-1, Type II, blocking binding namespace: molecular_function synonym: "IL-1 type II, blocking binding" EXACT [] xref: GO:0019968 is_a: CCO:F0004231 ! interleukin-1 binding [Term] id: CCO:F0004234 name: interleukin-10 binding namespace: molecular_function def: "Interacting selectively with interleukin-10." [GOC:jl] synonym: "IL-10 binding" EXACT [] xref: GO:0019969 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004235 name: interleukin-11 binding namespace: molecular_function def: "Interacting selectively with interleukin-11." [GOC:jl] synonym: "IL-11 binding" EXACT [] xref: GO:0019970 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004236 name: interleukin-12 binding namespace: molecular_function def: "Interacting selectively with interleukin-12." [GOC:jl] synonym: "IL-12 binding" EXACT [] xref: GO:0019972 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004237 name: interleukin-13 binding namespace: molecular_function def: "Interacting selectively with interleukin-13." [GOC:jl] synonym: "IL-13 binding" EXACT [] xref: GO:0019973 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004238 name: interleukin-14 binding namespace: molecular_function def: "Interacting selectively with interleukin-14." [GOC:jl] synonym: "IL-14 binding" EXACT [] xref: GO:0019974 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004239 name: interleukin-17 binding namespace: molecular_function def: "Interacting selectively with interleukin-17." [GOC:jl] synonym: "IL-17 binding" EXACT [] xref: GO:0019975 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004240 name: interleukin-2 binding namespace: molecular_function def: "Interacting selectively with interleukin-2." [GOC:jl] synonym: "IL-2 binding" EXACT [] xref: GO:0019976 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004241 name: interleukin-21 binding namespace: molecular_function def: "Interacting selectively with interleukin-21." [GOC:jl] synonym: "IL-21 binding" EXACT [] xref: GO:0019977 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004242 name: interleukin-3 binding namespace: molecular_function def: "Interacting selectively with interleukin-3." [GOC:jl] synonym: "IL-3 binding" EXACT [] xref: GO:0019978 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004243 name: interleukin-4 binding namespace: molecular_function def: "Interacting selectively with interleukin-4." [GOC:jl] synonym: "IL-4 binding" EXACT [] xref: GO:0019979 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004244 name: interleukin-5 binding namespace: molecular_function def: "Interacting selectively with interleukin-5." [GOC:jl] synonym: "IL-5 binding" EXACT [] xref: GO:0019980 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004245 name: interleukin-6 binding namespace: molecular_function def: "Interacting selectively with interleukin-6." [GOC:jl] synonym: "IL-6 binding" EXACT [] xref: GO:0019981 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004246 name: interleukin-7 binding namespace: molecular_function def: "Interacting selectively with interleukin-7." [GOC:jl] synonym: "IL-7 binding" EXACT [] xref: GO:0019982 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004247 name: interleukin-9 binding namespace: molecular_function def: "Interacting selectively with interleukin-9." [GOC:jl] synonym: "IL-9 binding" EXACT [] xref: GO:0019983 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0004248 name: diacylglycerol binding namespace: molecular_function def: "Interacting selectively with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma] xref: GO:0019992 is_a: CCO:F0001816 ! lipid binding [Term] id: CCO:F0004249 name: heme binding namespace: molecular_function def: "Interacting selectively with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai] subset: gosubset_prok synonym: "haem binding" EXACT [] xref: GO:0020037 is_a: CCO:F0006264 ! tetrapyrrole binding [Term] id: CCO:F0004250 name: passive transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022803 is_a: CCO:F0004284 ! transmembrane transporter activity [Term] id: CCO:F0004251 name: active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] synonym: "active carrier activity" EXACT [] synonym: "carrier activity" EXACT [] synonym: "permease activity" EXACT [] synonym: "pump activity" EXACT [] xref: GO:0022804 is_a: CCO:F0004284 ! transmembrane transporter activity [Term] id: CCO:F0004252 name: mobile ion carrier activity namespace: molecular_function def: "This is a type of carrier produced by bacteria. It enable passive transport by shielding the ion that is being transported from the lipid membrane. It carries an ion across the membrane by enclosing the ion and travelling across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionophore" BROAD [] xref: GO:0022809 is_a: CCO:F0004250 ! passive transmembrane transporter activity [Term] id: CCO:F0004253 name: membrane potential driven uniporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] synonym: "porter" BROAD [] xref: GO:0022810 is_a: CCO:F0004254 ! facilitated diffusion [Term] id: CCO:F0004254 name: facilitated diffusion namespace: molecular_function def: "Catalysis of the transfer of a single solute from one side of the membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] synonym: "porters" BROAD [] synonym: "uniporter activity z" EXACT [] xref: GO:0022814 is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0004255 name: large uncharged polar molecule transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022815 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0004256 name: sodium ion uniporter activity namespace: molecular_function def: "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022818 is_a: CCO:F0002562 ! sodium ion transmembrane transporter activity is_a: CCO:F0004253 ! membrane potential driven uniporter activity [Term] id: CCO:F0004257 name: potassium ion uniporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022819 is_a: CCO:F0002560 ! potassium ion transmembrane transporter activity is_a: CCO:F0004253 ! membrane potential driven uniporter activity [Term] id: CCO:F0004258 name: potassium ion symporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022820 is_a: CCO:F0002560 ! potassium ion transmembrane transporter activity is_a: CCO:F0002742 ! symporter activity [Term] id: CCO:F0004259 name: potassium ion antiporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022821 is_a: CCO:F0002560 ! potassium ion transmembrane transporter activity is_a: CCO:F0002746 ! antiporter activity [Term] id: CCO:F0004260 name: transmitter-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022824 is_a: CCO:F0002733 ! ligand-gated ion channel activity is_a: CCO:F0004267 ! transmitter-gated channel activity [Term] id: CCO:F0004261 name: phosphorylation-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022828 is_a: CCO:F0004268 ! gated channel activity [Term] id: CCO:F0004262 name: wide pore channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729] synonym: "gap junction activity" NARROW [] synonym: "non-gated, wide pore channel activity" EXACT [] xref: GO:0022829 is_a: CCO:F0002725 ! channel activity [Term] id: CCO:F0004263 name: narrow pore, gated channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729] synonym: "ion channels" EXACT [] xref: GO:0022831 is_a: CCO:F0004273 ! narrow pore channel activity [Term] id: CCO:F0004264 name: voltage-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022832 is_a: CCO:F0004268 ! gated channel activity [Term] id: CCO:F0004265 name: mechanically gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022833 is_a: CCO:F0004268 ! gated channel activity [Term] id: CCO:F0004266 name: ligand-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022834 is_a: CCO:F0004268 ! gated channel activity [Term] id: CCO:F0004267 name: transmitter-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular substance gated channel activity" EXACT [] synonym: "neurotransmitter-gated channel activity" EXACT [] xref: GO:0022835 is_a: CCO:F0004266 ! ligand-gated channel activity [Term] id: CCO:F0004268 name: gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport] xref: GO:0022836 is_a: CCO:F0002725 ! channel activity [Term] id: CCO:F0004269 name: substrate specific channel activity namespace: molecular_function def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport] xref: GO:0022838 is_a: CCO:F0002725 ! channel activity [Term] id: CCO:F0004270 name: ion gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport] xref: GO:0022839 is_a: CCO:F0004268 ! gated channel activity [Term] id: CCO:F0004271 name: leak channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022840 is_a: CCO:F0004273 ! narrow pore channel activity [Term] id: CCO:F0004272 name: potassium ion leak channel activity namespace: molecular_function def: "Catalysis of the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022841 is_a: CCO:F0002560 ! potassium ion transmembrane transporter activity is_a: CCO:F0004271 ! leak channel activity [Term] id: CCO:F0004273 name: narrow pore channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022842 is_a: CCO:F0002725 ! channel activity [Term] id: CCO:F0004274 name: voltage-gated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022843 is_a: CCO:F0001512 ! voltage-gated ion channel activity [Term] id: CCO:F0004275 name: acetylcholine-gated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022848 is_a: CCO:F0004260 ! transmitter-gated ion channel activity [Term] id: CCO:F0004276 name: glutamate-gated calcium ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022849 is_a: CCO:F0004260 ! transmitter-gated ion channel activity [Term] id: CCO:F0004277 name: serotonin-gated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022850 is_a: CCO:F0004260 ! transmitter-gated ion channel activity [Term] id: CCO:F0004278 name: GABA-gated chloride ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022851 is_a: CCO:F0004260 ! transmitter-gated ion channel activity [Term] id: CCO:F0004279 name: glycine-gated chloride ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022852 is_a: CCO:F0004260 ! transmitter-gated ion channel activity [Term] id: CCO:F0004280 name: active ion transmembrane transporter namespace: molecular_function def: "Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:def, GOC:mtg_transport, ISBN:0815340729] xref: GO:0022853 is_a: CCO:F0002557 ! ion transmembrane transporter activity is_a: CCO:F0004251 ! active transmembrane transporter activity [Term] id: CCO:F0004281 name: active large uncharged polar molecule transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022854 is_a: CCO:F0004251 ! active transmembrane transporter activity is_a: CCO:F0004255 ! large uncharged polar molecule transmembrane transporter activity [Term] id: CCO:F0004282 name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "glucose PTS transporter activity" EXACT [] xref: GO:0022855 is_a: CCO:F0001581 ! glucose transmembrane transporter activity is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: CCO:F0004283 name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sorbitol PTS transporter activity" EXACT [] xref: GO:0022856 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0002956 ! sorbitol transmembrane transporter activity [Term] id: CCO:F0004284 name: transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0005386 xref: GO:0015646 xref: GO:0022857 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0004285 name: alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022858 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0004286 name: dephosphorylation-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022859 is_a: CCO:F0004268 ! gated channel activity [Term] id: CCO:F0004287 name: transmembrane electron transfer carrier namespace: molecular_function def: "Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5] xref: GO:0022865 xref: TC:5 is_a: CCO:F0004284 ! transmembrane transporter activity [Term] id: CCO:F0004288 name: transmembrane 1-electron transfer carrier namespace: molecular_function def: "Enables transfer of 1 electron across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.B] xref: GO:0022866 is_a: CCO:F0004287 ! transmembrane electron transfer carrier [Term] id: CCO:F0004289 name: transmembrane 2-electron transfer carrier namespace: molecular_function def: "Enables transfer of 2 electrons across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.A] xref: GO:0022867 is_a: CCO:F0004287 ! transmembrane electron transfer carrier [Term] id: CCO:F0004290 name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "lactose PTS transporter activity" EXACT [] xref: GO:0022869 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0002632 ! lactose transmembrane transporter activity [Term] id: CCO:F0004291 name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "mannose PTS transporter activity" EXACT [] xref: GO:0022870 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0002958 ! mannose transmembrane transporter activity [Term] id: CCO:F0004292 name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sorbose PTS transporter activity" EXACT [] xref: GO:0022871 is_a: CCO:F0001581 ! glucose transmembrane transporter activity is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0004119 ! sorbose transmembrane transporter activity [Term] id: CCO:F0004293 name: protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "mannitol PTS transporter activity" EXACT [] xref: GO:0022872 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0002955 ! mannitol transmembrane transporter activity [Term] id: CCO:F0004294 name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "maltose PTS transporter activity" EXACT [] xref: GO:0022873 is_a: CCO:F0001589 ! maltose transmembrane transporter activity is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: CCO:F0004295 name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "cellobiose PTS transporter activity" EXACT [] xref: GO:0022874 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0004118 ! cellobiose transmembrane transporter activity [Term] id: CCO:F0004296 name: protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "galactitol PTS transporter activity" EXACT [] xref: GO:0022875 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0002957 ! galactitol transmembrane transporter activity [Term] id: CCO:F0004297 name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "galactosamine PTS transporter activity" EXACT [] xref: GO:0022876 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0004120 ! galactosamine transmembrane transporter activity [Term] id: CCO:F0004298 name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "fructose PTS transporter activity" EXACT [] xref: GO:0022877 is_a: CCO:F0001579 ! fructose transmembrane transporter activity is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: CCO:F0004299 name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sucrose PTS transporter activity" EXACT [] xref: GO:0022878 is_a: CCO:F0001968 ! sucrose transmembrane transporter activity is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0004119 ! sorbose transmembrane transporter activity [Term] id: CCO:F0004300 name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "trehalose PTS transporter activity" EXACT [] xref: GO:0022879 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0002954 ! trehalose transmembrane transporter activity is_a: CCO:F0002958 ! mannose transmembrane transporter activity [Term] id: CCO:F0004301 name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylglucosamine PTS transporter activity" EXACT [] xref: GO:0022880 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0002952 ! N-acetylglucosamine transmembrane transporter activity is_a: CCO:F0002954 ! trehalose transmembrane transporter activity [Term] id: CCO:F0004302 name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylgalactosamine PTS transporter activity" EXACT [] xref: GO:0022881 is_a: CCO:F0001581 ! glucose transmembrane transporter activity is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0002951 ! N-acetylgalactosamine transmembrane transporter activity [Term] id: CCO:F0004303 name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "beta-glucoside PTS transporter activity" EXACT [] xref: GO:0022882 is_a: CCO:F0002314 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: CCO:F0002953 ! beta-glucoside transmembrane transporter activity [Term] id: CCO:F0004304 name: zinc efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "zinc efflux permease activity" EXACT [] xref: GO:0022883 is_a: CCO:F0006231 ! cation efflux transmembrane transporter activity [Term] id: CCO:F0004305 name: macromolecule transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a macromolecule from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022884 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity [Term] id: CCO:F0004306 name: bacteriocin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a bacteriocin from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022885 is_a: CCO:F0002860 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: CCO:F0004307 name: channel-forming ionophore activity namespace: molecular_function def: "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionophore activity" BROAD [] xref: GO:0022886 is_a: CCO:F0002725 ! channel activity [Term] id: CCO:F0004308 name: serine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729] xref: GO:0022889 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0004309 name: inorganic cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0022890 is_a: CCO:F0001835 ! cation transmembrane transporter activity [Term] id: CCO:F0004310 name: substrate-specific transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jic, GOC:mtg_transport, ISBN:0815340729] xref: GO:0022891 is_a: CCO:F0004284 ! transmembrane transporter activity is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0004311 name: substrate-specific transporter activity namespace: molecular_function def: "Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:mtg_transport] xref: GO:0022892 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0004312 name: low-affinity tryptophan transmembrane transporter activity namespace: molecular_function def: "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:mtg_transport, ISBN:0815340729] synonym: "low-affinity tryptophan permease activity" RELATED [] xref: GO:0015510 xref: GO:0022893 is_a: CCO:F0002670 ! L-tryptophan transmembrane transporter activity [Term] id: CCO:F0004313 name: Intermediate conductance calcium-activated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] synonym: "IK calcium-activated potassium channel activity " EXACT [] synonym: "IK KCa channels" EXACT [] synonym: "intermdiate conductance KCa channels " EXACT [] xref: GO:0022894 is_a: CCO:F0002726 ! calcium-activated potassium channel activity [Term] id: CCO:F0004314 name: proton-dependent peptide secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport] subset: gosubset_prok synonym: "hydrogen/oligopeptide symporter" RELATED [] xref: GO:0022897 is_a: CCO:F0002671 ! peptide transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0004315 name: tryptase activity namespace: molecular_function def: "Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [EC:3.4.21.59] subset: gosubset_prok synonym: "lung tryptase activity" NARROW [EC:3.4.21.59] synonym: "mast cell neutral proteinase activity" EXACT [EC:3.4.21.59] synonym: "mast cell protease II activity" NARROW [EC:3.4.21.59] synonym: "mast cell proteinase II" RELATED [EC:3.4.21.59] synonym: "mast cell serine proteinase II" RELATED [EC:3.4.21.59] synonym: "mast cell serine proteinase tryptase activity" EXACT [EC:3.4.21.59] synonym: "mast cell tryptase activity" NARROW [EC:3.4.21.59] synonym: "pituitary tryptase activity" NARROW [EC:3.4.21.59] synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59] synonym: "skin tryptase activity" NARROW [EC:3.4.21.59] synonym: "tryptase M" RELATED [EC:3.4.21.59] xref: EC:3.4.21.59 xref: GO:0030019 xref: MetaCyc:3.4.21.59-RXN is_a: CCO:F0000720 ! trypsin activity [Term] id: CCO:F0004316 name: extracellular matrix structural constituent conferring tensile strength namespace: molecular_function def: "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194] xref: GO:0030020 is_a: CCO:F0001487 ! extracellular matrix structural constituent [Term] id: CCO:F0004317 name: extracellular matrix structural constituent conferring compression resistance namespace: molecular_function def: "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194] xref: GO:0030021 is_a: CCO:F0001487 ! extracellular matrix structural constituent [Term] id: CCO:F0004318 name: extracellular matrix constituent conferring elasticity namespace: molecular_function def: "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194] synonym: "elastin" RELATED [] xref: GO:0030023 is_a: CCO:F0001487 ! extracellular matrix structural constituent [Term] id: CCO:F0004319 name: amine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor." [EC:1.4.99.3] subset: gosubset_prok synonym: "amine: (acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] synonym: "MADH activity" EXACT [EC:1.4.99.3] synonym: "methylamine dehydrogenase activity" EXACT [EC:1.4.99.3] synonym: "primary-amine dehydrogenase activity" BROAD [EC:1.4.99.3] synonym: "primary-amine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] synonym: "primary-amine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] xref: EC:1.4.99.3 xref: GO:0030058 xref: MetaCyc:AMINE-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0058 is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0004320 name: aralkylamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor; acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine." [EC:1.4.99.4] synonym: "aralkylamine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.4] synonym: "aralkylamine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.4] synonym: "aromatic amine dehydrogenase activity" EXACT [EC:1.4.99.4] synonym: "dehydrogenase, arylamine" EXACT [EC:1.4.99.4] synonym: "tyramine dehydrogenase activity" EXACT [EC:1.4.99.4] xref: EC:1.4.99.4 xref: GO:0030059 xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0004321 name: L-malate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids." [EC:1.1.1.37] subset: gosubset_prok synonym: "(S)-malate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] synonym: "L-malate-NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] synonym: "malate (NAD) dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "malic acid dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "MDH" RELATED [EC:1.1.1.37] synonym: "NAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-dependent malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-L-malate dehydrogenase activity" EXACT [] synonym: "NAD-linked malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-specific malate dehydrogenase activity" EXACT [EC:1.1.1.37] xref: EC:1.1.1.37 xref: GO:0030060 xref: MetaCyc:MALATE-DEH-RXN xref: Reactome:19541 is_a: CCO:F0003217 ! malate dehydrogenase activity is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004322 name: HLA-A specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] xref: GO:0030107 is_a: CCO:F0004980 ! inhibitory MHC class I receptor activity [Term] id: CCO:F0004323 name: HLA-A specific activating MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] xref: GO:0030108 is_a: CCO:F0004981 ! activating MHC class I receptor activity [Term] id: CCO:F0004324 name: HLA-B specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] xref: GO:0030109 is_a: CCO:F0004980 ! inhibitory MHC class I receptor activity [Term] id: CCO:F0004325 name: HLA-C specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] xref: GO:0030110 is_a: CCO:F0004980 ! inhibitory MHC class I receptor activity [Term] id: CCO:F0004326 name: glial cell line-derived neurotrophic factor receptor binding namespace: molecular_function def: "A growth factor that binds to glial cell line-derived neurotrophic factor receptors." [PMID:11476867] synonym: "glial cell line-derived neurotrophic factor receptor ligand" NARROW [] xref: GO:0030116 is_a: CCO:F0001702 ! growth factor activity [Term] id: CCO:F0004327 name: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155] synonym: "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "GnTV activity" EXACT [EC:2.4.1.155] synonym: "N-acetylglucosaminyltransferase V activity" RELATED [EC:2.4.1.155] synonym: "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] xref: EC:2.4.1.155 xref: GO:0030144 xref: MetaCyc:2.4.1.155-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0004328 name: manganese ion binding namespace: molecular_function def: "Interacting selectively with manganese (Mn) ions." [GOC:ai] subset: gosubset_prok synonym: "manganese binding" EXACT [] xref: GO:0030145 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0004329 name: molybdenum ion binding namespace: molecular_function def: "Interacting selectively with molybdenum (Mo) ions." [GOC:ai] subset: gosubset_prok synonym: "molybdenum binding" EXACT [] xref: GO:0030151 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0004330 name: benzodiazepine receptor binding namespace: molecular_function def: "Interacting selectively with the peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832] synonym: "benzodiazepine receptor ligand" NARROW [] synonym: "diazepam binding inhibitor activity" RELATED [] xref: GO:0030156 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0004331 name: protein xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26] synonym: "peptide O-xylosyltransferase activity" EXACT [] synonym: "UDP-D-xylose:core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:core protein xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-xylose-core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "uridine diphosphoxylose-core protein beta-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" EXACT [EC:2.4.2.26] xref: EC:2.4.2.26 xref: GO:0030158 xref: MetaCyc:2.4.2.26-RXN is_a: CCO:F0005581 ! UDP-xylosyltransferase activity [Term] id: CCO:F0004332 name: receptor signaling complex scaffold activity namespace: molecular_function def: "Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah] synonym: "receptor signaling complex scaffold protein activity" EXACT [] synonym: "receptor signalling complex scaffold activity" EXACT [] xref: GO:0030159 is_a: CCO:F0005052 ! protein complex scaffold [Term] id: CCO:F0004333 name: GKAP/Homer scaffold activity namespace: molecular_function def: "Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses." [PMID:10506216] synonym: "GKAP/Homer scaffold protein" NARROW [] synonym: "postsynaptic density scaffold protein" NARROW [] xref: GO:0030160 is_a: CCO:F0004332 ! receptor signaling complex scaffold activity [Term] id: CCO:F0004334 name: calpain inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai] xref: GO:0030161 is_a: CCO:F0001224 ! cysteine protease inhibitor activity [Term] id: CCO:F0004335 name: PDZ domain binding namespace: molecular_function def: "Interacting selectively with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] synonym: "DHR-domain binding" EXACT [] synonym: "GLGF-domain binding" EXACT [] xref: GO:0030165 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004336 name: low-density lipoprotein binding namespace: molecular_function def: "Interacting selectively with low-density lipoprotein, one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "LDL binding" EXACT [] xref: GO:0030169 is_a: CCO:F0001687 ! lipoprotein binding [Term] id: CCO:F0004337 name: pyridoxal phosphate binding namespace: molecular_function def: "Interacting selectively with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "vitamin B6 binding" EXACT [] xref: GO:0030170 is_a: CCO:F0004191 ! vitamin binding is_a: CCO:F0007309 ! cofactor binding [Term] id: CCO:F0004338 name: voltage-gated proton channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a proton by a voltage-gated channel." [ISBN:10615049] synonym: "voltage gated proton channel activity" EXACT [] synonym: "voltage-dependent proton channel activity" EXACT [] xref: GO:0030171 is_a: CCO:F0004274 ! voltage-gated cation channel activity [Term] id: CCO:F0004339 name: troponin C binding namespace: molecular_function def: "Interacting selectively with troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] xref: GO:0030172 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0004340 name: nitric oxide transporter activity namespace: molecular_function def: "Enables the directed movement of nitric oxide, nitrogen monoxide, into, out of, within or between cells." [GOC:mah] subset: gosubset_prok xref: GO:0030184 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0004341 name: chaperone regulator activity namespace: molecular_function def: "Modulates the activity of a molecular chaperone." [GOC:mah] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: gosubset_prok xref: GO:0030188 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0004342 name: chaperone activator activity namespace: molecular_function def: "Increases the activity of a molecular chaperone." [GOC:mah] subset: gosubset_prok xref: GO:0030189 is_a: CCO:F0004341 ! chaperone regulator activity [Term] id: CCO:F0004343 name: chaperone inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a molecular chaperone." [GOC:mah] xref: GO:0030190 is_a: CCO:F0001213 ! enzyme inhibitor activity is_a: CCO:F0004341 ! chaperone regulator activity [Term] id: CCO:F0004344 name: Hsp70/Hsc70 protein inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] xref: GO:0030191 is_a: CCO:F0004343 ! chaperone inhibitor activity is_a: CCO:F0004345 ! Hsp70/Hsc70 protein regulator activity [Term] id: CCO:F0004345 name: Hsp70/Hsc70 protein regulator activity namespace: molecular_function def: "Modulates the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] subset: gosubset_prok xref: GO:0030192 is_a: CCO:F0004341 ! chaperone regulator activity [Term] id: CCO:F0004346 name: cyanide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: formamide = cyanide + H2O." [EC:4.2.1.66] synonym: "formamide dehydratase activity" EXACT [EC:4.2.1.66] synonym: "formamide hydro-lyase (cyanide-forming)" EXACT [EC:4.2.1.66] synonym: "formamide hydro-lyase activity" EXACT [EC:4.2.1.66] xref: EC:4.2.1.66 xref: GO:0030196 xref: MetaCyc:CYANIDE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004347 name: extracellular matrix constituent, lubricant activity namespace: molecular_function def: "Functions as a lubricant for an extracellular matrix, such as a mucous membrane." [GOC:mah] xref: GO:0030197 is_a: CCO:F0001487 ! extracellular matrix structural constituent [Term] id: CCO:F0004348 name: semaphorin receptor binding namespace: molecular_function def: "Interacting selectively with semaphorin receptors." [GOC:ceb, PMID:12001990] synonym: "plexin binding" NARROW [] synonym: "plexin ligand" NARROW [] synonym: "semaphorin receptor ligand" NARROW [] xref: GO:0030215 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0004349 name: apolipoprotein receptor activity namespace: molecular_function def: "Combining with an apolipoprotein, the protein component of a lipoprotein, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0030226 is_a: CCO:F0001226 ! receptor activity is_a: CCO:F0005523 ! apolipoprotein binding [Term] id: CCO:F0004350 name: apolipoprotein E receptor activity namespace: molecular_function def: "Combining with apolipoprotein E to initiate a change in cell activity." [GOC:mah] synonym: "ApoE receptor" EXACT [] xref: GO:0030227 is_a: CCO:F0004349 ! apolipoprotein receptor activity is_a: CCO:F0005525 ! apolipoprotein E binding [Term] id: CCO:F0004351 name: lipoprotein receptor activity namespace: molecular_function def: "Combining with a lipoprotein to initiate a change in cell activity. A lipoprotein is any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids; the lipid may be triacylglycerol, cholesterol, or phospholipid, or a combination of these." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0030228 is_a: CCO:F0001240 ! transmembrane receptor activity is_a: CCO:F0001687 ! lipoprotein binding [Term] id: CCO:F0004352 name: very-low-density lipoprotein receptor activity namespace: molecular_function def: "Combining with a very-low-density lipoprotein to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "VLDL receptor" EXACT [] xref: GO:0030229 is_a: CCO:F0004351 ! lipoprotein receptor activity is_a: CCO:F0005527 ! very-low-density lipoprotein binding [Term] id: CCO:F0004353 name: deoxynucleotide transmembrane transporter activity namespace: molecular_function def: "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231] xref: GO:0030233 is_a: CCO:F0002686 ! nucleotide transmembrane transporter activity [Term] id: CCO:F0004354 name: enzyme regulator activity namespace: molecular_function def: "Modulates the activity of an enzyme." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "enzyme modulator" EXACT [] xref: GO:0030234 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0004355 name: nitric-oxide synthase regulator activity namespace: molecular_function def: "Modulates the activity of nitric oxide synthase." [GOC:mah] comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'. synonym: "nitric oxide synthase regulator activity" EXACT [] xref: GO:0030235 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0004356 name: carbohydrate binding namespace: molecular_function def: "Interacting selectively with any carbohydrate." [GOC:mah] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "selectin" RELATED [] xref: GO:0030246 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0004357 name: polysaccharide binding namespace: molecular_function def: "Interacting selectively with any polysaccharide." [GOC:mah] subset: gosubset_prok xref: GO:0030247 is_a: CCO:F0000239 ! pattern binding is_a: CCO:F0004356 ! carbohydrate binding [Term] id: CCO:F0004358 name: cellulose binding namespace: molecular_function def: "Interacting selectively with cellulose." [GOC:mah] subset: gosubset_prok xref: GO:0030248 is_a: CCO:F0004357 ! polysaccharide binding [Term] id: CCO:F0004359 name: guanylate cyclase regulator activity namespace: molecular_function def: "Modulates the activity of guanylate cyclase." [GOC:mah] xref: GO:0030249 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0004360 name: guanylate cyclase activator activity namespace: molecular_function def: "Increases the activity of guanylate cyclase." [GOC:mah] synonym: "guanylin" EXACT [] xref: GO:0030250 is_a: CCO:F0001691 ! enzyme activator activity is_a: CCO:F0004359 ! guanylate cyclase regulator activity [Term] id: CCO:F0004361 name: guanylate cyclase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of guanylate cyclase." [GOC:mah] xref: GO:0030251 is_a: CCO:F0001213 ! enzyme inhibitor activity is_a: CCO:F0004359 ! guanylate cyclase regulator activity [Term] id: CCO:F0004362 name: quinate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: quinate + NAD+ = 5-dehydroquinate + NADH + H+." [EC:1.1.1.24] synonym: "quinate:NAD oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinate:NAD(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinic dehydrogenase activity" EXACT [EC:1.1.1.24] xref: EC:1.1.1.24 xref: GO:0030266 xref: MetaCyc:QUINATE-5-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004363 name: glyoxylate reductase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79] subset: gosubset_prok synonym: "glycolate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.79] synonym: "glyoxylate reductase (NADP+)" EXACT [EC:1.1.1.79] synonym: "NADPH-glyoxylate reductase activity" EXACT [EC:1.1.1.79] xref: EC:1.1.1.79 xref: GO:0030267 xref: MetaCyc:GLYOXYLATE-REDUCTASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004364 name: methylenetetrahydromethanopterin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.99.9] subset: gosubset_prok synonym: "5,10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9] synonym: "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.9] synonym: "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9] xref: EC:1.5.99.9 xref: GO:0018536 xref: GO:0030268 xref: MetaCyc:1.5.99.9-RXN xref: UM-BBD_enzymeID:e0124 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0004365 name: tetrahydromethanopterin S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [EC:2.1.1.86] subset: gosubset_prok synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "tetrahydromethanopterin methyltransferase activity" EXACT [EC:2.1.1.86] xref: EC:2.1.1.86 xref: GO:0018709 xref: GO:0030269 xref: MetaCyc:2.1.1.86-RXN xref: UM-BBD_enzymeID:e0145 is_a: CCO:F0001759 ! S-methyltransferase activity is_a: CCO:F0005622 ! 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity [Term] id: CCO:F0004366 name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + N5-formyl-5,6,7,8-tetrahydromethanopterin." [EC:2.3.1.101] subset: gosubset_prok synonym: "formylmethanofuran-tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "FTR" RELATED [EC:2.3.1.101] synonym: "N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity" EXACT [EC:2.3.1.101] xref: EC:2.3.1.101 xref: GO:0018714 xref: GO:0030270 xref: MetaCyc:2.3.1.101-RXN xref: UM-BBD_enzymeID:e0143 is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0004367 name: chymase activity namespace: molecular_function def: "Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [EC:3.4.21.39] synonym: "mast cell protease I activity" NARROW [EC:3.4.21.39] synonym: "mast cell serine proteinase" NARROW [EC:3.4.21.39] synonym: "SK protease activity" EXACT [EC:3.4.21.39] synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39] synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39] synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39] xref: EC:3.4.21.39 xref: GO:0030271 xref: MetaCyc:3.4.21.39-RXN is_a: CCO:F0000698 ! serine-type endopeptidase activity [Term] id: CCO:F0004368 name: 5-formyltetrahydrofolate cyclo-ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate." [EC:6.3.3.2] subset: gosubset_prok synonym: "5,10-methenyltetrahydrofolate synthetase activity" EXACT [EC:6.3.3.2] synonym: "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.2] synonym: "5-formyltetrahydrofolate cyclodehydrase" BROAD [EC:6.3.3.2] synonym: "5-Formyltetrahydrofolate cyclodehydrase activity" EXACT [EC:6.3.3.2] synonym: "formyltetrahydrofolic cyclodehydrase activity" EXACT [EC:6.3.3.2] synonym: "methenyl-THF synthetase activity" EXACT [EC:6.3.3.2] xref: EC:6.3.3.2 xref: GO:0019006 xref: GO:0030272 xref: MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN is_a: CCO:F0003441 ! cyclo-ligase activity [Term] id: CCO:F0004369 name: melanin-concentrating hormone receptor activity namespace: molecular_function def: "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah] synonym: "MCH receptor" EXACT [] xref: GO:0030273 is_a: CCO:F0003181 ! protein-hormone receptor activity [Term] id: CCO:F0004370 name: LIM domain binding namespace: molecular_function def: "Interacting selectively with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412] xref: GO:0030274 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004371 name: LRR domain binding namespace: molecular_function def: "Interacting selectively with a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560] xref: GO:0030275 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004372 name: clathrin binding namespace: molecular_function def: "Interacting selectively with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0030276 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004373 name: structural constituent of epidermis namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah] xref: GO:0030280 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0004374 name: structural constituent of cutaneous appendage namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437] xref: GO:0030281 is_a: CCO:F0004373 ! structural constituent of epidermis [Term] id: CCO:F0004375 name: 3(or 17)beta-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51] subset: gosubset_prok synonym: "17beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.51] synonym: "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase" EXACT [EC:1.1.1.51] synonym: "3beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.51] synonym: "3beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.51] synonym: "beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.51] xref: EC:1.1.1.51 xref: GO:0030283 xref: MetaCyc:1.1.1.51-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004376 name: estrogen receptor activity namespace: molecular_function def: "Combining with estrogen to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. xref: GO:0030284 is_a: CCO:F0000295 ! steroid hormone receptor activity [Term] id: CCO:F0004377 name: sphingolipid activator protein activity namespace: molecular_function def: "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "saposin" NARROW [] xref: GO:0030290 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0004378 name: protein serine/threonine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah] xref: GO:0030291 is_a: CCO:F0001216 ! protein kinase inhibitor activity [Term] id: CCO:F0004379 name: protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah] xref: GO:0030292 is_a: CCO:F0001216 ! protein kinase inhibitor activity [Term] id: CCO:F0004380 name: transmembrane receptor protein tyrosine kinase inhibitor activity namespace: molecular_function xref: GO:0030293 is_a: CCO:F0004379 ! protein tyrosine kinase inhibitor activity is_a: CCO:F0004459 ! receptor inhibitor activity [Term] id: CCO:F0004381 name: receptor signaling protein tyrosine kinase inhibitor activity namespace: molecular_function synonym: "receptor signalling protein tyrosine kinase inhibitor activity" EXACT [] xref: GO:0030294 is_a: CCO:F0004379 ! protein tyrosine kinase inhibitor activity [Term] id: CCO:F0004382 name: protein kinase activator activity namespace: molecular_function def: "Increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] subset: gosubset_prok xref: GO:0030295 is_a: CCO:F0004132 ! kinase activator activity is_a: CCO:F0004204 ! protein kinase regulator activity [Term] id: CCO:F0004383 name: protein tyrosine kinase activator activity namespace: molecular_function def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0030296 is_a: CCO:F0004382 ! protein kinase activator activity [Term] id: CCO:F0004384 name: transmembrane receptor protein tyrosine kinase activator activity namespace: molecular_function xref: GO:0030297 is_a: CCO:F0004383 ! protein tyrosine kinase activator activity is_a: CCO:F0004458 ! receptor activator activity [Term] id: CCO:F0004385 name: receptor signaling protein tyrosine kinase activator activity namespace: molecular_function synonym: "receptor signalling protein tyrosine kinase activator activity" EXACT [] xref: GO:0030298 is_a: CCO:F0004383 ! protein tyrosine kinase activator activity [Term] id: CCO:F0004386 name: stromelysin 2 activity namespace: molecular_function def: "Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [EC:3.4.24.17, EC:3.4.24.22] synonym: "matrix metalloproteinase 10 activity" EXACT [EC:3.4.24.22] synonym: "MMP-10" EXACT [] synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22] synonym: "transin 2 activity" EXACT [EC:3.4.24.22] xref: EC:3.4.24.22 xref: GO:0030303 xref: MetaCyc:3.4.24.22-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0004387 name: trypsin inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the serine endopeptidase trypsin." [GOC:ai] subset: gosubset_prok xref: GO:0030304 is_a: CCO:F0001223 ! serine-type endopeptidase inhibitor activity [Term] id: CCO:F0004388 name: heparanase activity namespace: molecular_function def: "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150] xref: GO:0030305 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0004389 name: ADP-ribosylation factor binding namespace: molecular_function def: "Interacting selectively with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ARF binding" EXACT [] xref: GO:0030306 is_a: CCO:F0004648 ! small GTPase binding [Term] id: CCO:F0004390 name: estrogen receptor binding namespace: molecular_function def: "Interacting selectively with an estrogen receptor." [GOC:ai] xref: GO:0030331 is_a: CCO:F0005586 ! steroid hormone receptor binding [Term] id: CCO:F0004391 name: cyclin binding namespace: molecular_function def: "Interacting selectively with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] xref: GO:0030332 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004392 name: DNA polymerase processivity factor activity namespace: molecular_function def: "An accessory subunit of DNA polymerase that acts to increase the processivity of polymerization." [UniProtKB:P28958] subset: gosubset_prok synonym: "processivity clamp" EXACT [] synonym: "sliding clamp" EXACT [] xref: GO:0030337 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0004393 name: CMP-N-acetylneuraminate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O." [EC:1.14.18.2] comment: Note that this was EC:1.14.13.45. synonym: "CMP-N-acetylneuraminate hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)" EXACT [EC:1.14.18.2] synonym: "CMP-N-acetylneuraminic acid hydroxylase activity" EXACT [] synonym: "CMP-Neu5Ac hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "cytidine monophosphoacetylneuraminate monooxygenase activity" EXACT [EC:1.14.18.2] synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "N-acetylneuraminic monooxygenase activity" EXACT [EC:1.14.18.2] xref: EC:1.14.18.2 xref: GO:0030338 xref: MetaCyc:1.14.13.45-RXN is_a: CCO:F0003299 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0004394 name: fatty-acyl-ethyl-ester synthase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67] synonym: "FAEE synthase activity" EXACT [EC:3.1.1.67] synonym: "FAEES activity" EXACT [EC:3.1.1.67] synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" EXACT [EC:3.1.1.67] xref: EC:3.1.1.67 xref: GO:0030339 xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0004395 name: hyaluronate lyase activity namespace: molecular_function def: "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1] subset: gosubset_prok synonym: "glucuronoglycosaminoglycan lyase activity" EXACT [EC:4.2.2.1] synonym: "hyaluronidase [but cf. EC 3.2.1.35 (hyalurononglucosaminidase) and EC 3.2.1.36 (hyaluronoglucuronidase)]" RELATED [EC:4.2.2.1] synonym: "hyaluronidase activity" BROAD [EC:4.2.2.1] synonym: "mucinase activity" EXACT [EC:4.2.2.1] synonym: "spreading factor activity" RELATED [EC:4.2.2.1] xref: EC:4.2.2.1 xref: GO:0030340 xref: MetaCyc:HYALURONATE-LYASE-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0004396 name: chondroitin AC lyase activity namespace: molecular_function def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5] subset: gosubset_prok synonym: "ChnAC" RELATED [] synonym: "chondroitin AC eliminase activity" EXACT [EC:4.2.2.5] synonym: "chondroitin lyase activity" EXACT [] synonym: "chondroitin sulfate lyase activity" EXACT [EC:4.2.2.5] synonym: "chondroitinase AC" RELATED [] synonym: "chondroitinase activity" BROAD [] xref: EC:4.2.2.5 xref: GO:0030341 xref: MetaCyc:4.2.2.5-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0004397 name: 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-1 of 25-hydroxycalciferol (25-hydroxyvitamin D3) to form 1-alpha,25-dihydroxycalciferol." [ISBN:0471331309 "Biochemical Pathways"] xref: GO:0030342 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0004398 name: vitamin D3 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-25 of calciferol (vitamin D3) to form 25-hydroxycalciferol." [ISBN:0471331309 "Biochemical Pathways"] synonym: "cholecalciferol 25-hydroxylase activity" EXACT [] xref: GO:0030343 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0004399 name: structural constituent of tooth enamel namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of tooth enamel." [GOC:mah] xref: GO:0030345 is_a: CCO:F0004317 ! extracellular matrix structural constituent conferring compression resistance [Term] id: CCO:F0004400 name: protein phosphatase 2B binding namespace: molecular_function def: "Interacting selectively with the enzyme protein phosphatase 2B." [GOC:jl] synonym: "calcineurin binding" EXACT [] xref: GO:0030346 is_a: CCO:F0004212 ! protein phosphatase binding [Term] id: CCO:F0004401 name: syntaxin-2 binding namespace: molecular_function def: "Interacting selectively with the SNAP receptor syntaxin-2." [GOC:ai] xref: GO:0030347 is_a: CCO:F0004214 ! syntaxin binding [Term] id: CCO:F0004402 name: syntaxin-3 binding namespace: molecular_function def: "Interacting selectively with the SNAP receptor syntaxin-3." [GOC:ai] xref: GO:0030348 is_a: CCO:F0004214 ! syntaxin binding [Term] id: CCO:F0004403 name: syntaxin-13 binding namespace: molecular_function def: "Interacting selectively with the SNAP receptor syntaxin-13." [GOC:ai] xref: GO:0030349 is_a: CCO:F0004214 ! syntaxin binding [Term] id: CCO:F0004404 name: iron-responsive element binding namespace: molecular_function def: "Interacting selectively with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843] synonym: "IRE binding" EXACT [] xref: GO:0030350 is_a: CCO:F0000313 ! mRNA binding [Term] id: CCO:F0004405 name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3.- xref: GO:0030351 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity [Term] id: CCO:F0004406 name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3.- xref: GO:0030352 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity [Term] id: CCO:F0004407 name: fibroblast growth factor receptor antagonist activity namespace: molecular_function def: "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah] synonym: "FGF receptor antagonist activity" EXACT [] synonym: "FGFR antagonist activity" EXACT [] xref: GO:0030353 is_a: CCO:F0001409 ! fibroblast growth factor receptor binding is_a: CCO:F0007301 ! receptor antagonist activity [Term] id: CCO:F0004408 name: melanin-concentrating hormone activity namespace: molecular_function xref: GO:0030354 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0004409 name: protein phosphatase type 2B regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 2B." [GOC:ai] synonym: "protein phosphatase type 2B, intrinsic regulator activity" NARROW [] xref: GO:0030359 is_a: CCO:F0004205 ! protein phosphatase regulator activity [Term] id: CCO:F0004410 name: protein phosphatase type 4 regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 4." [GOC:ai] synonym: "protein phosphatase type 4, intrinsic regulator activity" NARROW [] xref: GO:0030362 is_a: CCO:F0004205 ! protein phosphatase regulator activity [Term] id: CCO:F0004411 name: Mo-molybdopterin synthase activity namespace: molecular_function def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:8514783] synonym: "molybdopterin synthase activity" EXACT [] xref: GO:0030366 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0004412 name: interleukin-17 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-17 receptor." [GOC:ai] synonym: "IL-17" NARROW [] synonym: "interleukin-17 receptor ligand" NARROW [] xref: GO:0030367 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0004413 name: interleukin-17 receptor activity namespace: molecular_function def: "Combining with interleukin-17 to initiate a change in cell activity." [GOC:jl] synonym: "IL-17R" EXACT [] xref: GO:0030368 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0004239 ! interleukin-17 binding [Term] id: CCO:F0004414 name: ICAM-3 receptor activity namespace: molecular_function def: "Combining with ICAM-3, intercellular adhesion molecule 3, to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. xref: GO:0030369 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0004415 name: intercellular adhesion molecule-3 receptor binding namespace: molecular_function def: "Interacting selectively with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836] synonym: "ICAM-3 receptor binding" EXACT [] synonym: "ICAM-3 receptor ligand" NARROW [] synonym: "intercellular adhesion molecule-3 receptor ligand" NARROW [] xref: GO:0030370 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0004416 name: translation repressor activity namespace: molecular_function def: "Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt] xref: GO:0030371 is_a: CCO:F0006094 ! translation regulator activity [Term] id: CCO:F0004417 name: high molecular weight B cell growth factor receptor binding namespace: molecular_function def: "Interacting selectively with the high molecular weight B cell growth factor receptor." [GOC:ai] synonym: "high molecular weight B cell growth factor receptor ligand" NARROW [] synonym: "high molecular weight B lymphocyte growth factor receptor binding" EXACT [] synonym: "high molecular weight B-cell growth factor receptor binding" EXACT [] synonym: "high molecular weight B-lymphocyte growth factor receptor binding" EXACT [] xref: GO:0030372 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0004418 name: high molecular weight B cell growth factor receptor activity namespace: molecular_function def: "Combining with a high molecular weight B cell growth factor to initiate a change in cell activity." [GOC:ai] synonym: "high molecular weight B lymphocyte growth factor receptor activity" EXACT [] synonym: "high molecular weight B-cell growth factor receptor activity" EXACT [] synonym: "high molecular weight B-lymphocyte growth factor receptor activity" EXACT [] xref: GO:0030373 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0004419 name: ligand-dependent nuclear receptor transcription coactivator activity namespace: molecular_function synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT [] xref: GO:0030374 is_a: CCO:F0000300 ! transcription coactivator activity [Term] id: CCO:F0004420 name: thyroid hormone receptor coactivator activity namespace: molecular_function synonym: "thyroid hormone receptor co-activator activity" EXACT [] xref: GO:0030375 is_a: CCO:F0004419 ! ligand-dependent nuclear receptor transcription coactivator activity [Term] id: CCO:F0004421 name: U-plasminogen activator receptor activity namespace: molecular_function synonym: "uPAR" EXACT [] synonym: "urokinase plasminogen activator receptor" EXACT [] xref: GO:0030377 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0004422 name: serine racemase activity namespace: molecular_function def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd] xref: GO:0030378 is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0004423 name: neurotensin receptor activity, non-G-protein coupled namespace: molecular_function synonym: "neurotensin receptor activity, non G protein coupled" EXACT [] synonym: "non G protein coupled neurotensin receptor activity" EXACT [] synonym: "non-G-protein coupled neurotensin receptor activity" EXACT [] synonym: "non-G-protein-coupled neurotensin receptor activity" EXACT [] xref: GO:0030379 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0004424 name: interleukin-17E receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-17E receptor." [GOC:ai] synonym: "IL-17E" NARROW [] synonym: "interleukin-17E receptor ligand" NARROW [] xref: GO:0030380 is_a: CCO:F0001428 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding [Term] id: CCO:F0004425 name: ferredoxin:thioredoxin reductase activity namespace: molecular_function def: "Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide." [PMID:14769790] xref: GO:0030385 is_a: CCO:F0003311 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: CCO:F0004426 name: fructosamine-3-kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase." [PMID:11016445] xref: GO:0030387 is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0004427 name: lactose binding namespace: molecular_function def: "Interacting selectively with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:01928006X] xref: GO:0030395 is_a: CCO:F0007306 ! disaccharide binding [Term] id: CCO:F0004428 name: transcription antiterminator activity namespace: molecular_function def: "Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "transcriptional antiterminator activity" EXACT [] xref: GO:0030401 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0004429 name: matrilysin-2 activity namespace: molecular_function synonym: "matrix metalloproteinase 26" EXACT [] synonym: "MMP-26" EXACT [] xref: EC:3.4.24.- xref: GO:0030402 is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0004430 name: collagenase 4 activity namespace: molecular_function synonym: "matrix metalloproteinase 18" EXACT [] synonym: "MMP-18" NARROW [] xref: GO:0030403 is_a: CCO:F0001737 ! collagenase activity [Term] id: CCO:F0004431 name: collagenase 3 activity namespace: molecular_function synonym: "matrix metalloproteinase 13" EXACT [] synonym: "MMP-13" EXACT [] xref: GO:0030404 is_a: CCO:F0001737 ! collagenase activity [Term] id: CCO:F0004432 name: matrix metalloproteinase 19 activity namespace: molecular_function synonym: "MMP-19" EXACT [] xref: GO:0030405 is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0004433 name: matrix metalloproteinase 25 activity namespace: molecular_function synonym: "MMP-25" EXACT [] synonym: "MT6-MMP" EXACT [] xref: GO:0030406 is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0004434 name: formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid." [EC:2.1.2.4, EC:2.1.2.5, GOC:mah] subset: gosubset_prok synonym: "formiminotransferase activity" EXACT [] xref: EC:2.1.2.- xref: GO:0030407 is_a: CCO:F0003318 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: CCO:F0004435 name: glycine formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = tetrahydrofolate + N-formimidoylglycine." [EC:2.1.2.4] synonym: "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity" EXACT [EC:2.1.2.4] synonym: "FIG formiminotransferase activity" EXACT [EC:2.1.2.4] synonym: "formiminoglycine formiminotransferase activity" EXACT [EC:2.1.2.4] synonym: "glycine formiminotransferase activity" EXACT [] xref: EC:2.1.2.4 xref: GO:0030408 xref: MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN is_a: CCO:F0004434 ! formimidoyltransferase activity [Term] id: CCO:F0004436 name: glutamate formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [EC:2.1.2.5] subset: gosubset_prok synonym: "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity" EXACT [EC:2.1.2.5] synonym: "formiminoglutamic acid transferase activity" EXACT [EC:2.1.2.5] synonym: "formiminoglutamic formiminotransferase activity" EXACT [EC:2.1.2.5] synonym: "glutamate formiminotransferase activity" EXACT [] synonym: "glutamate formyltransferase activity" EXACT [EC:2.1.2.5] xref: EC:2.1.2.5 xref: GO:0030409 xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN is_a: CCO:F0004434 ! formimidoyltransferase activity [Term] id: CCO:F0004437 name: nicotianamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 S-adenosyl-L-methionine = 3 5'-S-methyl-5'-thioadenosine + nicotianamine." [EC:2.5.1.43] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.43] xref: EC:2.5.1.43 xref: GO:0030410 xref: MetaCyc:2.5.1.43-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0004438 name: scytalone dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O." [EC:4.2.1.94] synonym: "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)" EXACT [EC:4.2.1.94] synonym: "scytalone 7,8-hydro-lyase activity" EXACT [EC:4.2.1.94] xref: EC:4.2.1.94 xref: GO:0030411 xref: MetaCyc:SCYTALONE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0004439 name: formimidoyltetrahydrofolate cyclodeaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3." [EC:4.3.1.4] subset: gosubset_prok synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.4] synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)" EXACT [EC:4.3.1.4] synonym: "formiminotetrahydrofolate cyclodeaminase activity" EXACT [EC:4.3.1.4] xref: EC:4.3.1.4 xref: GO:0030412 xref: MetaCyc:4.3.1.4-RXN xref: Reactome:23291 is_a: CCO:F0003406 ! ammonia-lyase activity is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0004440 name: competence pheromone activity namespace: molecular_function def: "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645] subset: gosubset_prok xref: GO:0030413 is_a: CCO:F0001483 ! pheromone activity [Term] id: CCO:F0004441 name: protease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds." [GOC:jl] subset: gosubset_prok synonym: "peptidase inhibitor" EXACT [] xref: GO:0030414 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0004442 name: carboxypeptidase A inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the enzyme carboxypeptidase A." [GOC:ai] xref: GO:0030415 is_a: CCO:F0004441 ! protease inhibitor activity [Term] id: CCO:F0004443 name: kynureninase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [EC:3.7.1.3] subset: gosubset_prok synonym: "kynurenine hydrolase activity" EXACT [EC:3.7.1.3] synonym: "L-kynurenine hydrolase activity" EXACT [EC:3.7.1.3] synonym: "l-kynurenine hydrolase activity" EXACT [EC:3.7.1.3] xref: EC:3.7.1.3 xref: GO:0030429 xref: MetaCyc:KYNURENINASE-RXN xref: Reactome:23316 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0004444 name: inositol-4,5-bisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the removal of a phosphate group from the carbon-5 position of D-myo-inositol 4,5-bisphosphate." [GOC:mah] xref: GO:0030487 is_a: CCO:F0003119 ! inositol bisphosphate phosphatase activity [Term] id: CCO:F0004445 name: hemoglobin binding namespace: molecular_function def: "Interacting selectively with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "globin binding" NARROW [] synonym: "haemoglobin binding" EXACT [] xref: GO:0030492 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004446 name: inorganic diphosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of inorganic diphosphate across a membrane." [PMID:11326272] synonym: "inorganic pyrophosphate transporter" EXACT [] xref: GO:0030504 is_a: CCO:F0002581 ! inorganic anion transmembrane transporter activity [Term] id: CCO:F0004447 name: ankyrin binding namespace: molecular_function def: "Interacting selectively with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0030506 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0004448 name: spectrin binding namespace: molecular_function def: "Interacting selectively with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0030507 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0004449 name: thiol-disulfide exchange intermediate activity namespace: molecular_function def: "Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah] comment: Note that the synonyms 'glutaredoxin' and 'thioredoxin' represent gene products that could be annotated using this term. subset: gosubset_prok synonym: "glutaredoxin" NARROW [] synonym: "thiol-disulphide exchange intermediate activity" EXACT [] synonym: "thioredoxin" NARROW [] xref: GO:0030508 is_a: CCO:F0002533 ! disulfide oxidoreductase activity [Term] id: CCO:F0004450 name: snoRNA binding namespace: molecular_function def: "Interacting selectively with small nucleolar RNA." [GOC:mah] xref: GO:0030515 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0004451 name: snoRNP binding namespace: molecular_function def: "Interacting selectively with a protein constituent of a small nucleolar ribonucleoprotein particle." [GOC:mah] xref: GO:0030519 is_a: CCO:F0005783 ! ribonucleoprotein binding [Term] id: CCO:F0004452 name: dihydrolipoamide S-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide." [EC:2.3.1.12, GOC:mah] subset: gosubset_prok xref: GO:0030523 is_a: CCO:F0003140 ! S-acyltransferase activity [Term] id: CCO:F0004453 name: structural constituent of chromatin namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai] xref: GO:0030527 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0004454 name: transcription regulator activity namespace: molecular_function def: "Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "transcriptional regulator activity" EXACT [] xref: GO:0030528 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0004455 name: triplet codon-amino acid adaptor activity namespace: molecular_function def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. subset: goslim_candida subset: goslim_generic subset: goslim_yeast synonym: "transfer RNA" RELATED [] synonym: "tRNA" RELATED [] xref: GO:0030533 is_a: CCO:F0000092 ! base pairing with mRNA is_a: CCO:F0008241 ! molecular adaptor activity [Term] id: CCO:F0004456 name: Hsp70 protein binding namespace: molecular_function def: "Interacting selectively with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0030544 is_a: CCO:F0004628 ! heat shock protein binding [Term] id: CCO:F0004457 name: receptor regulator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed." [GOC:ceb] xref: GO:0030545 is_a: CCO:F0001374 ! receptor signaling protein activity [Term] id: CCO:F0004458 name: receptor activator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb] xref: GO:0030546 is_a: CCO:F0004457 ! receptor regulator activity [Term] id: CCO:F0004459 name: receptor inhibitor activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased." [GOC:ceb] xref: GO:0030547 is_a: CCO:F0004457 ! receptor regulator activity [Term] id: CCO:F0004460 name: acetylcholine receptor regulator activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah] xref: GO:0030548 is_a: CCO:F0004457 ! receptor regulator activity [Term] id: CCO:F0004461 name: acetylcholine receptor activator activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah] xref: GO:0030549 is_a: CCO:F0004458 ! receptor activator activity is_a: CCO:F0004460 ! acetylcholine receptor regulator activity [Term] id: CCO:F0004462 name: acetylcholine receptor inhibitor activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased." [GOC:mah] xref: GO:0030550 is_a: CCO:F0004459 ! receptor inhibitor activity is_a: CCO:F0004460 ! acetylcholine receptor regulator activity [Term] id: CCO:F0004463 name: cyclic nucleotide binding namespace: molecular_function def: "Interacting selectively with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai] subset: gosubset_prok xref: GO:0030551 is_a: CCO:F0000031 ! nucleotide binding [Term] id: CCO:F0004464 name: cAMP binding namespace: molecular_function def: "Interacting selectively with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai] subset: gosubset_prok synonym: "3',5' cAMP binding" EXACT [] synonym: "3',5'-cAMP binding" EXACT [] synonym: "adenosine 3',5'-cyclophosphate binding" EXACT [] synonym: "cyclic AMP binding" EXACT [] xref: GO:0030552 is_a: CCO:F0003068 ! AMP binding is_a: CCO:F0004463 ! cyclic nucleotide binding [Term] id: CCO:F0004465 name: cGMP binding namespace: molecular_function def: "Interacting selectively with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai] synonym: "3',5' cGMP binding" EXACT [] synonym: "3',5'-cGMP binding" EXACT [] synonym: "cyclic GMP binding" EXACT [] xref: GO:0030553 is_a: CCO:F0004045 ! GMP binding is_a: CCO:F0004463 ! cyclic nucleotide binding [Term] id: CCO:F0004466 name: adenyl nucleotide binding namespace: molecular_function def: "Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0030554 is_a: CCO:F0003548 ! purine nucleotide binding [Term] id: CCO:F0004467 name: RNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] synonym: "small nucleolar RNA" RELATED [] xref: GO:0030555 is_a: CCO:F0000091 ! base pairing with RNA [Term] id: CCO:F0004468 name: rRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] xref: GO:0030556 is_a: CCO:F0000123 ! base pairing with rRNA is_a: CCO:F0004467 ! RNA modification guide activity [Term] id: CCO:F0004469 name: tRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] xref: GO:0030557 is_a: CCO:F0000125 ! base pairing with tRNA is_a: CCO:F0004467 ! RNA modification guide activity [Term] id: CCO:F0004470 name: RNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] xref: GO:0030558 is_a: CCO:F0004467 ! RNA modification guide activity [Term] id: CCO:F0004471 name: rRNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] xref: GO:0030559 is_a: CCO:F0004468 ! rRNA modification guide activity is_a: CCO:F0004470 ! RNA pseudouridylation guide activity [Term] id: CCO:F0004472 name: tRNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] xref: GO:0030560 is_a: CCO:F0004469 ! tRNA modification guide activity is_a: CCO:F0004470 ! RNA pseudouridylation guide activity [Term] id: CCO:F0004473 name: RNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] xref: GO:0030561 is_a: CCO:F0004467 ! RNA modification guide activity [Term] id: CCO:F0004474 name: rRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] xref: GO:0030562 is_a: CCO:F0004468 ! rRNA modification guide activity is_a: CCO:F0004473 ! RNA 2'-O-ribose methylation guide activity [Term] id: CCO:F0004475 name: snRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745] comment: Note that this term may be useful for annotating snoRNAs. xref: GO:0030563 is_a: CCO:F0004473 ! RNA 2'-O-ribose methylation guide activity is_a: CCO:F0004478 ! snRNA modification guide activity [Term] id: CCO:F0004476 name: tRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] xref: GO:0030564 is_a: CCO:F0004469 ! tRNA modification guide activity is_a: CCO:F0004473 ! RNA 2'-O-ribose methylation guide activity [Term] id: CCO:F0004477 name: snRNA pseudouridylation guide activity namespace: molecular_function def: "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745] comment: Note that this term may be useful for annotating snoRNAs. xref: GO:0030565 is_a: CCO:F0004470 ! RNA pseudouridylation guide activity is_a: CCO:F0004478 ! snRNA modification guide activity [Term] id: CCO:F0004478 name: snRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] xref: GO:0030566 is_a: CCO:F0000124 ! base pairing with snRNA is_a: CCO:F0004467 ! RNA modification guide activity [Term] id: CCO:F0004479 name: prothrombin activator activity namespace: molecular_function def: "Increases the rate of proteolysis catalyzed by thrombin." [GOC:mah] subset: gosubset_prok xref: GO:0030567 is_a: CCO:F0003185 ! protease activator activity [Term] id: CCO:F0004480 name: plasmin inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the serine endopeptidase plasmin." [GOC:mah] xref: GO:0030568 is_a: CCO:F0001223 ! serine-type endopeptidase inhibitor activity [Term] id: CCO:F0004481 name: chymotrypsin inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah] xref: GO:0030569 is_a: CCO:F0001223 ! serine-type endopeptidase inhibitor activity [Term] id: CCO:F0004482 name: pectate lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2] subset: gosubset_prok synonym: "(1->4)-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.2] synonym: "alpha-1,4-D-endopolygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "endo-alpha-1,4-polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "endogalacturonate transeliminase activity" EXACT [EC:4.2.2.2] synonym: "endopectin methyltranseliminase activity" EXACT [EC:4.2.2.2] synonym: "pectate transeliminase activity" EXACT [EC:4.2.2.2] synonym: "pectic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "pectic acid transeliminase activity" EXACT [EC:4.2.2.2] synonym: "pectic lyase activity" BROAD [EC:4.2.2.2] synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.2] synonym: "PGA lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonate lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic acid trans-eliminase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic transeliminase activity" EXACT [EC:4.2.2.2] synonym: "PPase-N activity" EXACT [EC:4.2.2.2] xref: EC:4.2.2.2 xref: GO:0030570 xref: MetaCyc:4.2.2.2-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0004483 name: phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) moiety." [GOC:mb] subset: gosubset_prok xref: GO:0030572 is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0004484 name: quinone cofactor methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb] subset: gosubset_prok xref: GO:0030580 is_a: CCO:F0001756 ! C-methyltransferase activity [Term] id: CCO:F0004485 name: phosphoenolpyruvate carboxykinase (diphosphate) activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + oxaloacetate = phosphate + phosphoenolpyruvate + CO2." [EC:4.1.1.38] synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.38] synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.38] synonym: "PEP carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] synonym: "PEPCTrP" RELATED [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxykinase (pyrophosphate) activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.38] synonym: "phosphopyruvate carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphopyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] xref: EC:4.1.1.38 xref: GO:0030585 xref: MetaCyc:4.1.1.38-RXN is_a: CCO:F0000990 ! phosphoenolpyruvate carboxykinase activity [Term] id: CCO:F0004487 name: NAD DNA ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the ADP-ribose moiety of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983] xref: GO:0030591 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0004488 name: neurotransmitter receptor activity namespace: molecular_function def: "Combining with a neurotransmitter to initiate a change in cell activity." [GOC:jl] xref: GO:0030594 is_a: CCO:F0001226 ! receptor activity is_a: CCO:F0005633 ! neurotransmitter binding [Term] id: CCO:F0004489 name: alpha-L-rhamnosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40] subset: gosubset_prok synonym: "alpha-L-rhamnosidase N" RELATED [EC:3.2.1.40] synonym: "alpha-L-rhamnosidase T" RELATED [EC:3.2.1.40] synonym: "alpha-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.40] xref: EC:3.2.1.40 xref: GO:0030596 xref: MetaCyc:3.2.1.40-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0004490 name: RNA glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule." [GOC:mah] subset: gosubset_prok xref: GO:0030597 is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0004491 name: rRNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah] subset: gosubset_prok synonym: "gelonin" RELATED [EC:3.2.2.22] synonym: "mirabilis antiviral protein" RELATED [EC:3.2.2.22] synonym: "momorcochin-S" RELATED [EC:3.2.2.22] synonym: "nigrin b" RELATED [EC:3.2.2.22] synonym: "ribosomal ribonucleate N-glycosidase activity" EXACT [EC:3.2.2.22] synonym: "ricin" RELATED [EC:3.2.2.22] synonym: "RNA N-glycosidase activity" EXACT [EC:3.2.2.22] synonym: "rRNA N-glycohydrolase activity" EXACT [EC:3.2.2.22] synonym: "rRNA N-glycosidase activity" EXACT [] synonym: "saporins" RELATED [EC:3.2.2.22] xref: EC:3.2.2.22 xref: GO:0030598 xref: MetaCyc:3.2.2.22-RXN is_a: CCO:F0004490 ! RNA glycosylase activity [Term] id: CCO:F0004492 name: pectinesterase activity namespace: molecular_function def: "Catalysis of the reaction: pectin + n H2O = n methanol + pectate." [EC:3.1.1.11] subset: gosubset_prok synonym: "pectase activity" EXACT [EC:3.1.1.11] synonym: "pectin demethoxylase activity" EXACT [EC:3.1.1.11] synonym: "pectin methoxylase activity" EXACT [EC:3.1.1.11] synonym: "pectin methyl esterase activity" EXACT [EC:3.1.1.11] synonym: "pectin methylesterase activity" EXACT [] synonym: "pectin pectylhydrolase activity" EXACT [EC:3.1.1.11] synonym: "pectinoesterase activity" EXACT [EC:3.1.1.11] xref: EC:3.1.1.11 xref: GO:0030599 xref: MetaCyc:PECTINESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0004493 name: feruloyl esterase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73] synonym: "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity" EXACT [EC:3.1.1.73] synonym: "cinnAE" RELATED [EC:3.1.1.73] synonym: "cinnamoyl ester hydrolase activity" EXACT [] synonym: "FAE-I" RELATED [EC:3.1.1.73] synonym: "FAE-II" RELATED [EC:3.1.1.73] synonym: "FAE-III" RELATED [EC:3.1.1.73] synonym: "FAEA" RELATED [EC:3.1.1.73] synonym: "ferulic acid esterase activity" EXACT [EC:3.1.1.73] synonym: "hemicellulase accessory" RELATED [EC:3.1.1.73] synonym: "hydroxycinnamoyl esterase activity" EXACT [EC:3.1.1.73] xref: EC:3.1.1.73 xref: GO:0030600 xref: MetaCyc:3.1.1.73-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0004494 name: aminopeptidase B activity namespace: molecular_function def: "Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6] synonym: "arginyl aminopeptidase activity" EXACT [] synonym: "arylamidase II" RELATED [EC:3.4.11.6] synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6] synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6] synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6] xref: EC:3.4.11.6 xref: GO:0030601 xref: MetaCyc:3.4.11.6-RXN is_a: CCO:F0000646 ! aminopeptidase activity [Term] id: CCO:F0004495 name: chymosin activity namespace: molecular_function def: "Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4] synonym: "rennin" RELATED [EC:3.4.23.4] synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4] xref: EC:3.4.23.4 xref: GO:0030602 xref: MetaCyc:3.4.23.4-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0004496 name: oxaloacetase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate + H2O = oxalate + acetate." [EC:3.7.1.1] synonym: "oxalacetic hydrolase activity" EXACT [EC:3.7.1.1] synonym: "oxaloacetate acetylhydrolase activity" EXACT [EC:3.7.1.1] xref: EC:3.7.1.1 xref: GO:0030603 xref: MetaCyc:OXALOACETASE-RXN is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0004497 name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+; catalyzes the formation of 2-C-methyl-D-erythritol from 1-deoxy-D-xylulose-5-phosphate as the second step in the non-mevalonate pathway for terpenoid synthesis." [EC:1.1.1.267, GOC:mb] subset: gosubset_prok synonym: "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity" EXACT [EC:1.1.1.267] synonym: "1-deoxyxylulose-5-phosphate reductoisomerase activity" EXACT [EC:1.1.1.267] synonym: "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.267] synonym: "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity" EXACT [EC:1.1.1.267] synonym: "DOXP reductoisomerase activity" EXACT [] synonym: "DXP-reductoisomerase activity" EXACT [EC:1.1.1.267] xref: EC:1.1.1.267 xref: GO:0030604 xref: MetaCyc:DXPREDISOM-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004498 name: arsenate reductase activity namespace: molecular_function def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah] subset: gosubset_prok xref: GO:0030611 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0004499 name: arsenate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is NADPH -> thioredoxin reductase -> thioredoxin -> arsenate reductase." [GOC:kd] xref: GO:0030612 is_a: CCO:F0004498 ! arsenate reductase activity [Term] id: CCO:F0004500 name: oxidoreductase activity, acting on phosphorus or arsenic in donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah] comment: Note that enzymes of class EC:1.20.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" NARROW [] xref: EC:1.20 xref: GO:0030613 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0004501 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah] subset: gosubset_prok synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor" EXACT [] xref: EC:1.20.4 xref: GO:0030614 is_a: CCO:F0004500 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: CCO:F0004502 name: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity namespace: molecular_function def: "A TGFbeta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] comment: Note that this term can be used in place of the obsolete molecular function term 'common-partner SMAD protein ; GO:0005073' and is useful for annotating proteins of the SMAD family. synonym: "common-partner SMAD protein" RELATED [] synonym: "TGF-beta receptor, common-partner cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, common-partner cytoplasmic mediator activity" EXACT [] xref: GO:0030616 is_a: CCO:F0001382 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: CCO:F0004503 name: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity namespace: molecular_function def: "A TGFbeta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503] comment: Note that this term can be used in place of the obsolete molecular function term 'inhibitory SMAD protein ; GO:0005074' and is useful for annotating proteins of the SMAD family. synonym: "inhibitory SMAD protein" RELATED [] synonym: "TGF-beta receptor, inhibitory cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, inhibitory cytoplasmic mediator activity" EXACT [] xref: GO:0030617 is_a: CCO:F0001382 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: CCO:F0004504 name: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity namespace: molecular_function def: "A TGFbeta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] comment: Note that this term can be used in place of the obsolete molecular function term 'pathway-specific SMAD protein ; GO:0005075' and is useful for annotating proteins of the SMAD family. synonym: "pathway-specific SMAD protein" NARROW [] synonym: "TGF-beta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] xref: GO:0030618 is_a: CCO:F0001382 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: CCO:F0004505 name: U1 snRNA binding namespace: molecular_function def: "Interacting selectively with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). xref: GO:0030619 is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0004506 name: U2 snRNA binding namespace: molecular_function def: "Interacting selectively with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl] xref: GO:0030620 is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0004507 name: U4 snRNA binding namespace: molecular_function def: "Interacting selectively with the U4 small nuclear RNA (U4 snRNA)." [GOC:jl] xref: GO:0030621 is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0004508 name: U4atac snRNA binding namespace: molecular_function def: "Interacting selectively with the U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl] xref: GO:0030622 is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0004509 name: U5 snRNA binding namespace: molecular_function def: "Interacting selectively with the U5 small nuclear RNA (U5 snRNA)." [GOC:jl] xref: GO:0030623 is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0004510 name: U6atac snRNA binding namespace: molecular_function def: "Interacting selectively with the U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl] xref: GO:0030624 is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0004511 name: U11 snRNA binding namespace: molecular_function def: "Interacting selectively with the U11 small nuclear RNA (U11 snRNA)." [GOC:jl] xref: GO:0030625 is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0004512 name: U12 snRNA binding namespace: molecular_function def: "Interacting selectively with the U12 small nuclear RNA (U12 snRNA)." [GOC:jl] xref: GO:0030626 is_a: CCO:F0003544 ! snRNA binding [Term] id: CCO:F0004513 name: pre-mRNA 5'-splice site binding namespace: molecular_function def: "Interacting selectively with the pre-mRNA 5' splice site sequence." [GOC:jl] synonym: "pre-mRNA 5' splice site binding" EXACT [] xref: GO:0030627 is_a: CCO:F0000313 ! mRNA binding is_a: CCO:F0004638 ! RNA splicing factor activity, transesterification mechanism [Term] id: CCO:F0004514 name: pre-mRNA 3'-splice site binding namespace: molecular_function def: "Interacting selectively with the pre-mRNA 3' splice site sequence." [GOC:jl] synonym: "pre-mRNA 3' splice site binding" EXACT [] xref: GO:0030628 is_a: CCO:F0000313 ! mRNA binding is_a: CCO:F0004638 ! RNA splicing factor activity, transesterification mechanism [Term] id: CCO:F0004515 name: U6 snRNA 3'-end binding namespace: molecular_function def: "Interacting selectively with the 3' end of the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). synonym: "U6 snRNA 3' end binding" EXACT [] xref: GO:0030629 is_a: CCO:F0003545 ! U6 snRNA binding [Term] id: CCO:F0004516 name: protein binding, bridging namespace: molecular_function def: "Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other." [GOC:mah] subset: gosubset_prok synonym: "protein-protein adaptor" RELATED [] xref: GO:0030674 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004517 name: Rac GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rac family." [GOC:mah] xref: GO:0030675 is_a: CCO:F0001405 ! Rho GTPase activator activity [Term] id: CCO:F0004518 name: Rac guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: GO:0030676 is_a: CCO:F0001394 ! Rho guanyl-nucleotide exchange factor activity [Term] id: CCO:F0004519 name: caspase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455] synonym: "caspase-1 activity" NARROW [] synonym: "caspase-10 activity" NARROW [] synonym: "caspase-2 activity" NARROW [] synonym: "caspase-3 activity" NARROW [] synonym: "caspase-4 activity" NARROW [] synonym: "caspase-5 activity" NARROW [] synonym: "caspase-6 activity" NARROW [] synonym: "caspase-7 activity" NARROW [] synonym: "caspase-8 activity" NARROW [] synonym: "caspase-9 activity" NARROW [] synonym: "effector caspase activity" NARROW [] synonym: "signaling (initiator) caspase activity" NARROW [] xref: GO:0004199 xref: GO:0030693 xref: Reactome:82077 is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0004520 name: GTPase regulator activity namespace: molecular_function def: "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] subset: gosubset_prok xref: GO:0030695 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0004521 name: tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"] comment: Note that the term name mentions a specific position within a tRNA because no other names have yet arisen for this activity, and because the position is conserved in nearly all tRNAs. The term nevertheless can be used for activities that methylase an analogous residue at a position other than 54, if such is found, and synonyms that mention positions applicable to other tRNAs or species may also be added. synonym: "RUMT" EXACT [] xref: GO:0030696 is_a: CCO:F0003113 ! tRNA (uracil) methyltransferase activity [Term] id: CCO:F0004522 name: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"] synonym: "RUMT" BROAD [] synonym: "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity" EXACT [] xref: GO:0030697 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity is_a: CCO:F0004521 ! tRNA (m5U54) methyltransferase activity [Term] id: CCO:F0004523 name: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"] synonym: "RUMT" BROAD [] xref: GO:0030698 is_a: CCO:F0004521 ! tRNA (m5U54) methyltransferase activity is_a: CCO:F0005619 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: CCO:F0004524 name: glycine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + ammonia + thioredoxin disulfide = glycine + phosphate + thioredoxin." [EC:1.21.4.2] subset: gosubset_prok synonym: "acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)" EXACT [EC:1.21.4.2] xref: EC:1.21.4.2 xref: GO:0030699 is_a: CCO:F0007826 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: CCO:F0004525 name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37] subset: gosubset_prok synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.37] synonym: "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD--azoferredoxin (ADP-ribose)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD-azoferredoxin (ADPribose)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.37 xref: GO:0030701 xref: MetaCyc:2.4.2.37-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0004526 name: acetoacetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA." [EC:6.2.1.16] subset: gosubset_prok synonym: "acetoacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.16] synonym: "acetoacetyl-CoA synthetase activity" EXACT [] xref: EC:6.2.1.16 xref: GO:0030729 xref: MetaCyc:ACETOACETATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0004527 name: guanidinoacetate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine." [EC:2.1.1.2] synonym: "GA methylpherase activity" EXACT [EC:2.1.1.2] synonym: "guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] synonym: "guanidinoacetate transmethylase activity" EXACT [EC:2.1.1.2] synonym: "guanidoacetate methyltransferase activity" EXACT [EC:2.1.1.2] synonym: "methionine-guanidinoacetic transmethylase activity" EXACT [EC:2.1.1.2] synonym: "S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] xref: EC:2.1.1.2 xref: GO:0030731 xref: MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004528 name: methionine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12] synonym: "methionine methyltransferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosyl methionine:methionine methyl transferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosylmethionine-methionine methyltransferase activity" EXACT [EC:2.1.1.12] xref: EC:2.1.1.12 xref: GO:0030732 xref: MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004529 name: fatty-acid O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15] synonym: "fatty acid methyltransferase activity" EXACT [EC:2.1.1.15] synonym: "fatty acid O-methyltransferase activity" EXACT [EC:2.1.1.15] synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" EXACT [EC:2.1.1.15] xref: EC:2.1.1.15 xref: GO:0030733 xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004530 name: polysaccharide O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18] synonym: "acylpolysacharide 6-methyltransferase activity" EXACT [EC:2.1.1.18] synonym: "polysaccharide methyltransferase activity" EXACT [EC:2.1.1.18] synonym: "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity" EXACT [EC:2.1.1.18] xref: EC:2.1.1.18 xref: GO:0030734 xref: MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004531 name: carnosine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine." [EC:2.1.1.22] synonym: "S-adenosyl-L-methionine:carnosine N-methyltransferase activity" EXACT [EC:2.1.1.22] xref: EC:2.1.1.22 xref: GO:0030735 xref: MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004532 name: phenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole." [EC:2.1.1.25] synonym: "PMT" RELATED [EC:2.1.1.25] synonym: "S-adenosyl-L-methionine:phenol O-methyltransferase activity" EXACT [EC:2.1.1.25] xref: EC:2.1.1.25 xref: GO:0030736 xref: MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004533 name: iodophenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-iodophenol = S-adenosyl-L-homocysteine + 2-iodophenol methyl ether." [EC:2.1.1.26] synonym: "S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity" EXACT [EC:2.1.1.26] xref: EC:2.1.1.26 xref: GO:0030737 xref: MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004534 name: tyramine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = S-adenosyl-L-homocysteine + N-methyltyramine." [EC:2.1.1.27] synonym: "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)" EXACT [EC:2.1.1.27] synonym: "S-adenosyl-L-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] synonym: "S-adenosyl-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] synonym: "tyramine methylpherase activity" EXACT [EC:2.1.1.27] xref: EC:2.1.1.27 xref: GO:0030738 xref: MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004535 name: O-demethylpuromycin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38] subset: gosubset_prok synonym: "O-demethylpuromycin methyltransferase activity" EXACT [EC:2.1.1.38] synonym: "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity" EXACT [EC:2.1.1.38] xref: EC:2.1.1.38 xref: GO:0030739 xref: MetaCyc:2.1.1.38-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004536 name: inositol 3-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-3-O-methyl-myo-inositol." [EC:2.1.1.39] synonym: "inositol L-1-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39] synonym: "myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.39] synonym: "myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "S-adenosylmethionine:myo-inositol 1-methyltransferase activity" EXACT [EC:2.1.1.39] xref: EC:2.1.1.39 xref: GO:0030740 xref: MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004537 name: inositol 1-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-1-O-methyl-myo-inositol." [EC:2.1.1.40] synonym: "inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.40] synonym: "inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] synonym: "inositol D-1-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "S-adenosylmethionine:myo-inositol 3-methyltransferase activity" RELATED [EC:2.1.1.40] xref: EC:2.1.1.40 xref: GO:0030741 xref: MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004538 name: GTP-dependent protein binding namespace: molecular_function def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP." [GOC:go_curators] xref: GO:0030742 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004539 name: rRNA (adenosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.66] subset: gosubset_prok synonym: "ribosomal ribonucleate adenosine 2'-methyltransferase activity" EXACT [EC:2.1.1.66] synonym: "RNA-pentose methylase activity" RELATED [EC:2.1.1.66] synonym: "rRNA adenosine 2'-methylase activity" EXACT [EC:2.1.1.66] synonym: "S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity" EXACT [EC:2.1.1.66] synonym: "thiostrepton-resistance methylase activity" NARROW [EC:2.1.1.66] xref: EC:2.1.1.66 xref: GO:0030743 xref: MetaCyc:2.1.1.66-RXN is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0003155 ! rRNA (adenine) methyltransferase activity [Term] id: CCO:F0004540 name: luteolin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,3',4'-tetrahydroxyflavone = S-adenosyl-L-homocysteine + 5,7,4'-trihydroxy-3'-methoxyflavone." [EC:2.1.1.42] synonym: "luteolin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "luteolin methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-dihydric phenol meta-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-dihydric phenol methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-diphenol m-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] xref: EC:2.1.1.42 xref: GO:0030744 xref: MetaCyc:LUTEOLIN-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004541 name: dimethylhistidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + NN1,NN1-dimethyl-L-histidine = S-adenosyl-L-homocysteine + NN1,NN1,NN1-trimethyl-L-histidine." [EC:2.1.1.44] synonym: "dimethylhistidine methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "histidine-alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity" EXACT [EC:2.1.1.44] xref: EC:2.1.1.44 xref: GO:0030745 xref: MetaCyc:2.1.1.44-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004542 name: isoflavone 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46] synonym: "4'-hydroxyisoflavone methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "isoflavone methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "isoflavone O-methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.46] xref: EC:2.1.1.46 xref: GO:0030746 xref: MetaCyc:ISOFLAVONE-4 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004543 name: indolepyruvate C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." [EC:2.1.1.47] synonym: "indolepyruvate 3-methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "indolepyruvate methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "indolepyruvic acid methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] xref: EC:2.1.1.47 xref: GO:0030747 xref: MetaCyc:INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004544 name: amine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine." [EC:2.1.1.49] synonym: "arylamine N-methyltransferase activity" NARROW [EC:2.1.1.49] synonym: "nicotine N-methyltransferase activity" NARROW [EC:2.1.1.49] synonym: "S-adenosyl-L-methionine:amine N-methyltransferase activity" EXACT [EC:2.1.1.49] synonym: "tryptamine methyltransferase" NARROW [EC:2.1.1.49] synonym: "tryptamine N-methyltransferase activity" NARROW [EC:2.1.1.49] xref: EC:2.1.1.49 xref: GO:0030748 xref: MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004545 name: loganate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50] synonym: "loganate methyltransferase activity" EXACT [EC:2.1.1.50] synonym: "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity" EXACT [EC:2.1.1.50] synonym: "S-adenosyl-L-methionine:loganic acid methyltransferase activity" EXACT [EC:2.1.1.50] xref: EC:2.1.1.50 xref: GO:0030749 xref: MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004546 name: putrescine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = S-adenosyl-L-homocysteine + N-methylputrescine." [EC:2.1.1.53] synonym: "putrescine methyltransferase activity" EXACT [EC:2.1.1.53] synonym: "S-adenosyl-L-methionine:putrescine N-methyltransferase activity" EXACT [EC:2.1.1.53] xref: EC:2.1.1.53 xref: GO:0030750 xref: MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004547 name: licodione 2'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2'-O-methyllicodione." [EC:2.1.1.65] synonym: "S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity" EXACT [EC:2.1.1.65] xref: EC:2.1.1.65 xref: GO:0030751 xref: MetaCyc:LICODIONE-2 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004548 name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69] synonym: "bergaptol 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "bergaptol methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "BMT activity" EXACT [EC:2.1.1.69] synonym: "furanocoumarin 5-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "furanocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" EXACT [EC:2.1.1.69] xref: EC:2.1.1.69 xref: GO:0030752 xref: GO:0030764 xref: MetaCyc:2.1.1.69-RXN xref: MetaCyc:BERGAPTOL-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004549 name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 8-methoxyfuranocoumarin." [EC:2.1.1.70] synonym: "furanocoumarin 8-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "furanocoumarin 8-O-methyl-transferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "XMT activity" RELATED [EC:2.1.1.70] xref: EC:2.1.1.70 xref: GO:0030753 xref: MetaCyc:2.1.1.70-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004550 name: apigenin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75] synonym: "flavonoid methyltransferase activity" EXACT [EC:2.1.1.75] synonym: "flavonoid O-methyltransferase activity" BROAD [EC:2.1.1.75] synonym: "S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.75] xref: EC:2.1.1.75 xref: GO:0030754 xref: MetaCyc:APIGENIN-4 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004551 name: quercetin 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76] synonym: "flavonoid 3-methyltransferase activity" EXACT [EC:2.1.1.76] synonym: "flavonol 3-O-methyltransferase activity" RELATED [EC:2.1.1.76] synonym: "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity" EXACT [EC:2.1.1.76] xref: EC:2.1.1.76 xref: GO:0030755 xref: MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004552 name: isoorientin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoorientin = S-adenosyl-L-homocysteine + isoscoparin." [EC:2.1.1.78] synonym: "isoorientin 3'-methyltransferase activity" EXACT [EC:2.1.1.78] synonym: "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.78] xref: EC:2.1.1.78 xref: GO:0030756 xref: MetaCyc:ISOORIENTIN-3 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004553 name: 3-methylquercitin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5,7-tetrahydroxy-3-methoxyflavone = S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-3,7-dimethoxy-flavone." [EC:2.1.1.82] synonym: "3-methylquercetin 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] synonym: "7-OMT activity" RELATED [EC:2.1.1.82] synonym: "flavonol 7-methyltransferase activity" RELATED [EC:2.1.1.82] synonym: "flavonol 7-O-methyltransferase activity" RELATED [EC:2.1.1.82] synonym: "S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] xref: EC:2.1.1.82 xref: GO:0030757 xref: MetaCyc:2.1.1.82-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004554 name: 3,7-dimethylquercitin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5-trihydroxy-3,7-dimethoxyflavone = S-adenosyl-L-homocysteine + 3',5-dihydroxy-3,4',7-trimethoxy-flavone." [EC:2.1.1.83] synonym: "3,7-dimethylquercetin 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] synonym: "4'-OMT activity" RELATED [EC:2.1.1.83] synonym: "flavonol 4'-methyltransferase activity" RELATED [EC:2.1.1.83] synonym: "flavonol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83] synonym: "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] synonym: "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] xref: EC:2.1.1.83 xref: GO:0030758 xref: MetaCyc:2.1.1.83-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004555 name: methylquercetagetin 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5,6-tetrahydroxy-3,7-dimethoxy-flavone = S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-3,6,7-trimethoxyflavone." [EC:2.1.1.84] synonym: "6-OMT" RELATED [EC:2.1.1.84] synonym: "flavonol 6-methyltransferase activity" EXACT [EC:2.1.1.84] synonym: "flavonol 6-O-methyltransferase activity" RELATED [EC:2.1.1.84] synonym: "S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity" EXACT [EC:2.1.1.84] xref: EC:2.1.1.84 xref: GO:0030759 xref: MetaCyc:2.1.1.84-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004556 name: pyridine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + pyridine = S-adenosyl-L-homocysteine + N-methylpyridinium." [EC:2.1.1.87] synonym: "pyridine methyltransferase activity" EXACT [EC:2.1.1.87] synonym: "S-adenosyl-L-methionine:pyridine N-methyltransferase activity" EXACT [EC:2.1.1.87] xref: EC:2.1.1.87 xref: GO:0030760 xref: MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004557 name: 8-hydroxyquercitin 8-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone = S-adenosyl-L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxy-flavone." [EC:2.1.1.88] synonym: "8-hydroxyquercetin 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] synonym: "flavonol 8-methyltransferase activity" EXACT [EC:2.1.1.88] synonym: "flavonol 8-O-methyltransferase activity" RELATED [EC:2.1.1.88] synonym: "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] xref: EC:2.1.1.88 xref: GO:0030761 xref: MetaCyc:2.1.1.88-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004558 name: tetrahydrocolumbamine 2-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine." [EC:2.1.1.89] synonym: "S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity" EXACT [EC:2.1.1.89] synonym: "tetrahydrocolumbamine methyltransferase activity" EXACT [EC:2.1.1.89] xref: EC:2.1.1.89 xref: GO:0030762 xref: MetaCyc:2.1.1.89-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004559 name: isobutyraldoxime O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-methylpropanal oxime = S-adenosyl-L-homocysteine + 2-methylpropanal O-methyloxime." [EC:2.1.1.91] synonym: "aldoxime methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "S-adenosylmethionine:aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] xref: EC:2.1.1.91 xref: GO:0030763 xref: MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004560 name: xanthotoxol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + O-methylxanthotoxol." [EC:2.1.1.93] synonym: "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity" EXACT [EC:2.1.1.93] synonym: "xanthotoxol methyltransferase activity" EXACT [EC:2.1.1.93] xref: EC:2.1.1.93 xref: GO:0030765 xref: MetaCyc:XANTHOTOXOL-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004561 name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94] synonym: "11-demethyl-17-deacetylvindoline 11-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "tabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] xref: EC:2.1.1.94 xref: GO:0030766 xref: MetaCyc:2.1.1.94-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004562 name: 3-hydroxyanthranilate 4-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hydroxyanthranilate = S-adenosyl-L-homocysteine + 3-hydroxy-4-methylanthranilate." [EC:2.1.1.97] synonym: "3-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.97] synonym: "S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity" EXACT [EC:2.1.1.97] xref: EC:2.1.1.97 xref: GO:0030767 xref: MetaCyc:2.1.1.97-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004563 name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxy-tabersonine = S-adenosyl-L-homocysteine + deacetoxyvindoline." [EC:2.1.1.99] synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "NMT activity" EXACT [EC:2.1.1.99] synonym: "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] xref: EC:2.1.1.99 xref: GO:0030768 xref: MetaCyc:2.1.1.99-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004564 name: macrocin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + macrocin = S-adenosyl-L-homocysteine + tylosin." [EC:2.1.1.101] subset: gosubset_prok synonym: "macrocin methyltransferase activity" EXACT [EC:2.1.1.101] synonym: "S-adenosyl-L-methionine-macrocin O-methyltransferase activity" EXACT [EC:2.1.1.101] synonym: "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity" EXACT [EC:2.1.1.101] xref: EC:2.1.1.101 xref: GO:0030769 xref: MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004565 name: demethylmacrocin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin." [EC:2.1.1.102] synonym: "demethylmacrocin methyltransferase activity" EXACT [EC:2.1.1.102] synonym: "S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity" EXACT [EC:2.1.1.102] xref: EC:2.1.1.102 xref: GO:0030770 xref: MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004566 name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-benzoyl-4-hydroxyanthranilate = S-adenosyl-L-homocysteine + N-benzoyl-4-methoxyanthranilate." [EC:2.1.1.105] synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.1.1.105] synonym: "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.105] synonym: "S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity" EXACT [EC:2.1.1.105] xref: EC:2.1.1.105 xref: GO:0030771 xref: MetaCyc:2.1.1.105-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004567 name: tryptophan 2-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan." [EC:2.1.1.106] synonym: "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity" EXACT [EC:2.1.1.106] synonym: "S-adenosylmethionine:tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] synonym: "tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] xref: EC:2.1.1.106 xref: GO:0030772 xref: MetaCyc:TRYPTOPHAN-2-C-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004568 name: 6-hydroxymellein O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-hydroxymellein = S-adenosyl-L-homocysteine + 6-methoxymellein." [EC:2.1.1.108] synonym: "6-hydroxymellein methyltransferase activity" EXACT [EC:2.1.1.108] synonym: "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity" EXACT [EC:2.1.1.108] xref: EC:2.1.1.108 xref: GO:0030773 xref: MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004569 name: anthranilate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = S-adenosyl-L-homocysteine + N-methylanthranilate." [EC:2.1.1.111] synonym: "anthranilic acid N-methyltransferase activity" EXACT [EC:2.1.1.111] synonym: "S-adenosyl-L-methionine:anthranilate N-methyltransferase activity" EXACT [EC:2.1.1.111] xref: EC:2.1.1.111 xref: GO:0030774 xref: MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004570 name: glucuronoxylan 4-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112] synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" EXACT [EC:2.1.1.112] xref: EC:2.1.1.112 xref: GO:0030775 xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004573 name: columbamine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine." [EC:2.1.1.118] synonym: "S-adenosyl-L-methionine:columbamine O-methyltransferase activity" EXACT [EC:2.1.1.118] xref: EC:2.1.1.118 xref: GO:0030778 xref: MetaCyc:2.1.1.118-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004574 name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine = S-adenosyl-L-homocysteine + dihydrochelirubine." [EC:2.1.1.119] synonym: "S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity" EXACT [EC:2.1.1.119] xref: EC:2.1.1.119 xref: GO:0030779 xref: MetaCyc:2.1.1.119-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004575 name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine = S-adenosyl-L-homocysteine + dihydromacarpine." [EC:2.1.1.120] synonym: "S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity" EXACT [EC:2.1.1.120] xref: EC:2.1.1.120 xref: GO:0030780 xref: MetaCyc:2.1.1.120-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004576 name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121] synonym: "S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity" EXACT [EC:2.1.1.121] xref: EC:2.1.1.121 xref: GO:0030781 xref: MetaCyc:2.1.1.121-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004579 name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116] synonym: "S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" EXACT [EC:2.1.1.116] xref: EC:2.1.1.116 xref: GO:0030784 xref: MetaCyc:2.1.1.116-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004582 name: inositol 4-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 4-methyl-myo-inositol." [EC:2.1.1.129] synonym: "myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] synonym: "myo-inositol 6-O-methyltransferase activity" RELATED [EC:2.1.1.129] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity" EXACT [EC:2.1.1.129] synonym: "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] xref: EC:2.1.1.129 xref: GO:0030787 xref: MetaCyc:2.1.1.129-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004583 name: precorrin-2 C20-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A." [EC:2.1.1.130] subset: gosubset_prok synonym: "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity" EXACT [EC:2.1.1.130] synonym: "S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity" EXACT [EC:2.1.1.130] xref: EC:2.1.1.130 xref: GO:0030788 xref: MetaCyc:2.1.1.130-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004584 name: precorrin-3B C17-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131] subset: gosubset_prok synonym: "CobJ" RELATED [EC:2.1.1.131] synonym: "precorrin-3 methylase activity" EXACT [EC:2.1.1.131] synonym: "precorrin-3 methyltransferase activity" EXACT [EC:2.1.1.131] synonym: "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity" EXACT [EC:2.1.1.131] xref: EC:2.1.1.131 xref: GO:0030789 xref: MetaCyc:2.1.1.131-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004585 name: chlorophenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136] synonym: "halogenated phenol O-methyltransferase activity" BROAD [EC:2.1.1.136] synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] synonym: "trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] xref: EC:2.1.1.136 xref: GO:0030790 xref: MetaCyc:2.1.1.136-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004586 name: arsenite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137] comment: Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792). synonym: "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity" EXACT [EC:2.1.1.137] synonym: "S-adenosyl-L-methionine:arsenite As-methyltransferase activity" EXACT [EC:2.1.1.137] synonym: "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity" EXACT [EC:2.1.1.137] xref: EC:2.1.1.137 xref: GO:0030791 xref: MetaCyc:2.1.1.137-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004587 name: methylarsonite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [EC:2.1.1.138] comment: Note that EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137). xref: EC:2.1.1.- xref: GO:0030792 xref: MetaCyc:2.1.1.138-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004588 name: 3'-demethylstaurosporine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine." [EC:2.1.1.139] synonym: "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] synonym: "S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] synonym: "staurosporine synthase activity" EXACT [EC:2.1.1.139] xref: EC:2.1.1.139 xref: GO:0030793 xref: MetaCyc:2.1.1.139-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004590 name: jasmonate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate." [EC:2.1.1.141] synonym: "jasmonic acid carboxyl methyltransferase activity" EXACT [EC:2.1.1.141] synonym: "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity" EXACT [EC:2.1.1.141] synonym: "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity" EXACT [] xref: EC:2.1.1.141 xref: GO:0030795 xref: GO:0045546 xref: MetaCyc:RXN1F-28 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004591 name: cycloartenol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = S-adenosyl-L-homocysteine + (24R)-24-methylcycloarta-8,25-dien-3N2-ol." [EC:2.1.1.142] synonym: "S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity" EXACT [EC:2.1.1.142] synonym: "sterol C-methyltransferase activity" BROAD [EC:2.1.1.142] xref: EC:2.1.1.142 xref: GO:0030796 xref: MetaCyc:2.1.1.142-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004592 name: 24-methylenesterol C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 24-methylenelophenol = S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol." [EC:2.1.1.143] synonym: "24-methylenelophenol C-24(1)-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "24-methylenelophenol C-241-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "SMT(2) activity" NARROW [EC:2.1.1.143] synonym: "SMT2" RELATED [EC:2.1.1.143] xref: EC:2.1.1.143 xref: GO:0030797 xref: MetaCyc:2.1.1.143-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004593 name: trans-aconitate 2-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate." [EC:2.1.1.144] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity" EXACT [EC:2.1.1.144] xref: EC:2.1.1.144 xref: GO:0030798 xref: MetaCyc:RXN0-2441 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0004594 name: threo-3-hydroxyaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: threo-3-hydroxy-L-aspartate = oxaloacetate + NH3." [EC:4.3.1.16, PMID:10481099] synonym: "3-hydroxyaspartate dehydratase activity" BROAD [GOC:mcc, PMID:10481099] synonym: "L-threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] xref: EC:4.3.1.16 xref: GO:0030848 xref: MetaCyc:4.3.1.16-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0004595 name: beta-2-microglobulin binding namespace: molecular_function def: "Interacting selectively with beta-2-microglobulin." [GOC:mah] xref: GO:0030881 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004596 name: lipid antigen binding namespace: molecular_function def: "Interacting selectively with a lipid antigen." [PMID:14500461] xref: GO:0030882 is_a: CCO:F0000342 ! antigen binding is_a: CCO:F0001816 ! lipid binding [Term] id: CCO:F0004597 name: endogenous lipid antigen binding namespace: molecular_function def: "Interacting selectively with an endogenous cellular lipid antigen." [PMID:14500461] xref: GO:0030883 is_a: CCO:F0004596 ! lipid antigen binding [Term] id: CCO:F0004598 name: exogenous lipid antigen binding namespace: molecular_function def: "Interacting selectively with an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461] xref: GO:0030884 is_a: CCO:F0004596 ! lipid antigen binding [Term] id: CCO:F0004599 name: actin-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "actin-activated ATPase activity" EXACT [] xref: GO:0030898 is_a: CCO:F0005696 ! ATPase activity, coupled [Term] id: CCO:F0004600 name: calcium-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of calcium ion (Ca2+)." [GOC:mah] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. xref: GO:0030899 is_a: CCO:F0005696 ! ATPase activity, coupled [Term] id: CCO:F0004601 name: TPR domain binding namespace: molecular_function def: "Interacting selectively with a tetratricopeptide repeat (TPR) domain of a protein, the consensu thes sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah] xref: GO:0030911 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004602 name: dopachrome decarboxylase activity namespace: molecular_function def: "Catalysis of the decarboxylation of L-dopachrome to form 5,6-dihydroxyindole." [PMID:12164780] synonym: "dopachrome conversion activity" BROAD [] xref: GO:0030928 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0004603 name: chloroplast targeting sequence binding namespace: molecular_function def: "Interacting selectively with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah] xref: GO:0030941 is_a: CCO:F0001368 ! signal sequence binding [Term] id: CCO:F0004604 name: endoplasmic reticulum signal peptide binding namespace: molecular_function def: "Interacting selectively with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah] synonym: "ER signal peptide binding" EXACT [] xref: GO:0030942 is_a: CCO:F0001368 ! signal sequence binding [Term] id: CCO:F0004605 name: mitochondrion targeting sequence binding namespace: molecular_function def: "Interacting selectively with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah] synonym: "mitochondrial targeting sequence binding" EXACT [] xref: GO:0030943 is_a: CCO:F0001368 ! signal sequence binding [Term] id: CCO:F0004606 name: DDEL sequence binding namespace: molecular_function def: "Interacting selectively with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah] xref: GO:0030944 is_a: CCO:F0006275 ! ER retention sequence binding [Term] id: CCO:F0004607 name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate namespace: molecular_function def: "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd] xref: GO:0030945 is_a: CCO:F0001090 ! protein tyrosine phosphatase activity [Term] id: CCO:F0004608 name: protein tyrosine phosphatase activity, metal-dependent namespace: molecular_function def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate, by a mechanism that requires metal ions." [GOC:mah] xref: GO:0030946 is_a: CCO:F0001090 ! protein tyrosine phosphatase activity [Term] id: CCO:F0004609 name: potassium ion binding namespace: molecular_function def: "Interacting selectively with potassium (K+) ions." [GOC:mah] subset: gosubset_prok xref: GO:0030955 is_a: CCO:F0004664 ! alkali metal ion binding [Term] id: CCO:F0004610 name: Tat protein binding namespace: molecular_function def: "Interacting selectively with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689] xref: GO:0030957 is_a: CCO:F0001738 ! transcription factor binding [Term] id: CCO:F0004611 name: receptor tyrosine kinase binding namespace: molecular_function def: "Interacting selectively with a receptor that possesses protein tyrosine kinase activity." [GOC:mah] synonym: "transmembrane receptor protein tyrosine kinase ligand binding" RELATED [] xref: GO:0030971 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0004612 name: molybdate ion binding namespace: molecular_function def: "Interacting selectively with molybdate (MoO4 2-) ions." [GOC:mlg] subset: gosubset_prok xref: GO:0030973 is_a: CCO:F0005807 ! anion binding [Term] id: CCO:F0004613 name: thiamin binding namespace: molecular_function def: "Interacting selectively with thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg] synonym: "thiamine binding" EXACT [] synonym: "vitamin B1 binding" EXACT [] xref: GO:0030975 is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0004614 name: thiamin pyrophosphate binding namespace: molecular_function def: "Interacting selectively with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg, http://cancerweb.ncl.ac.uk/] synonym: "aneurine pyrophosphate binding" EXACT [] synonym: "cocarboxylase binding" EXACT [] synonym: "diphosphothiamin binding" EXACT [] synonym: "thiamine pyrophosphate binding" EXACT [] synonym: "TPP binding" EXACT [] xref: GO:0030976 is_a: CCO:F0004191 ! vitamin binding is_a: CCO:F0007988 ! coenzyme binding [Term] id: CCO:F0004615 name: taurine binding namespace: molecular_function def: "Interacting selectively with taurine." [GOC:mlg] xref: GO:0030977 is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0004616 name: mismatched DNA binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing one or more mismatches." [GOC:mah] xref: GO:0030983 is_a: CCO:F0000282 ! double-stranded DNA binding [Term] id: CCO:F0004617 name: kininogen binding namespace: molecular_function def: "Interacting selectively with a kininogen, any of a group of plasma proteins that are kinin precursors." [GOC:mah, PMID:9520414] xref: GO:0030984 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004618 name: high molecular weight kininogen binding namespace: molecular_function def: "Interacting selectively with a kininogen of high molecular mass." [GOC:mah, PMID:9520414] synonym: "HK binding" EXACT [] synonym: "HMW kininogen binding" EXACT [] xref: GO:0030985 is_a: CCO:F0004617 ! kininogen binding [Term] id: CCO:F0004619 name: low molecular weight kininogen binding namespace: molecular_function def: "Interacting selectively with a kininogen of low molecular mass." [GOC:mah, PMID:9520414] synonym: "LK binding" EXACT [] synonym: "LMW kininogen binding" EXACT [] xref: GO:0030986 is_a: CCO:F0004617 ! kininogen binding [Term] id: CCO:F0004620 name: high molecular weight kininogen receptor binding namespace: molecular_function def: "Interacting selectively with a high molecular weight kininogen receptor." [GOC:mah] xref: GO:0030987 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0004621 name: filamin binding namespace: molecular_function def: "Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782] xref: GO:0031005 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0004622 name: filamin-A binding namespace: molecular_function def: "Interacting selectively with filamin-A." [GOC:mah, PMID:11336782] synonym: "ABP-280 binding" NARROW [] synonym: "alpha-filamin binding" NARROW [] synonym: "filamin A binding" EXACT [] synonym: "filamin-1 binding" NARROW [] xref: GO:0031006 is_a: CCO:F0004621 ! filamin binding [Term] id: CCO:F0004623 name: filamin-B binding namespace: molecular_function def: "Interacting selectively with filamin-B." [GOC:mah, PMID:11336782] synonym: "ABP-278/276 binding" NARROW [] synonym: "beta-filamin binding" NARROW [] synonym: "filamin B binding" EXACT [] synonym: "filamin-3 binding" NARROW [] xref: GO:0031007 is_a: CCO:F0004621 ! filamin binding [Term] id: CCO:F0004624 name: filamin-C binding namespace: molecular_function def: "Interacting selectively with filamin-C, a filamin isoform that contains an 81 amino acid insertion in repeat 20, not present in filamin-A or -B." [GOC:mah, PMID:11336782] synonym: "ABPL binding" NARROW [] synonym: "filamin C binding" EXACT [] synonym: "filamin-2 binding" NARROW [] synonym: "gamma-filamin binding" NARROW [] xref: GO:0031008 is_a: CCO:F0004621 ! filamin binding [Term] id: CCO:F0004625 name: troponin I binding namespace: molecular_function def: "Interacting selectively with troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194] xref: GO:0031013 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0004626 name: troponin T binding namespace: molecular_function def: "Interacting selectively with troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] xref: GO:0031014 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0004627 name: cysteine desulfurase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7] subset: gosubset_prok synonym: "cysteine desulfurylase activity" EXACT [EC:2.8.1.7] synonym: "IscS" RELATED [EC:2.8.1.7] synonym: "L-cysteine:enzyme cysteine sulfurtransferase activity" EXACT [EC:2.8.1.7] synonym: "NIFS" RELATED [EC:2.8.1.7] synonym: "NifS" RELATED [EC:2.8.1.7] synonym: "SufS" RELATED [EC:2.8.1.7] xref: EC:2.8.1.7 xref: GO:0031071 is_a: CCO:F0003355 ! sulfurtransferase activity [Term] id: CCO:F0004628 name: heat shock protein binding namespace: molecular_function def: "Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah] xref: GO:0031072 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004629 name: cholesterol 26-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol." [GOC:mah, PMID:950499] xref: GO:0031073 is_a: CCO:F0001866 ! steroid hydroxylase activity [Term] id: CCO:F0004630 name: histone deacetylase activity (H3-K14 specific) namespace: molecular_function def: "Catalysis of the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [GOC:mah, PMID:11884604] xref: GO:0031078 is_a: CCO:F0000816 ! histone deacetylase activity [Term] id: CCO:F0004631 name: picornain 3C activity namespace: molecular_function def: "Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28] synonym: "3C protease activity" EXACT [EC:3.4.22.28] synonym: "3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "coxsackievirus 3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28] synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28] synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "hepatitis A virus 3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28] synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28] synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "protease 3C" RELATED [EC:3.4.22.28] synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28] synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28] xref: EC:3.4.22.28 xref: GO:0031079 is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0004632 name: alpha(1,2)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,2)-linkage." [GOC:mah] subset: gosubset_prok xref: GO:0031127 is_a: CCO:F0001884 ! fucosyltransferase activity [Term] id: CCO:F0004633 name: serine 3-dehydrogenase namespace: molecular_function def: "L-serine + NADP+ = 2-ammoniomalonate semialdehyde + NADPH + H+." [EC:1.1.1.276] synonym: "L-serine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.276] xref: EC:1.1.1.276 xref: GO:0031132 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004634 name: histone lysine N-methyltransferase activity (H3-K79 specific) namespace: molecular_function def: "Catalysis of the addition of a methyl group onto lysine at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351] xref: GO:0031151 is_a: CCO:F0003617 ! histone-lysine N-methyltransferase activity [Term] id: CCO:F0004635 name: ornithine N5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + O2 + donor-H2 = N5-hydroxy-L-ornithine + acceptor + H2O." [GOC:mah, PMID:12828635] xref: GO:0031172 is_a: CCO:F0000894 ! monooxygenase activity [Term] id: CCO:F0004636 name: endo-1,4-beta-xylanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8] synonym: "1,4-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "1,4-beta-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "beta-1,4-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "beta-D-xylanase activity" EXACT [EC:3.2.1.8] synonym: "beta-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "endo-1,4-b-xylanase activity" EXACT [] synonym: "endo-1,4-beta-D-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "xylanase" BROAD [EC:3.2.1.8] xref: EC:3.2.1.8 xref: GO:0031176 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0004637 name: phosphopantetheine binding namespace: molecular_function def: "Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [ChEBI:16858, GOC:mah] xref: GO:0031177 is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0004638 name: RNA splicing factor activity, transesterification mechanism namespace: molecular_function def: "An activity which assists splicing of substrate RNA(s) by facilitating the formation and stabilization of a series of catalytic conformations in which key RNA sequences are positioned for a series of two transesterification reactions which result in removal of the intron sequence and joining of two exons." [GOC:krc] comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. synonym: "pre-mRNA splicing factor activity" RELATED [] synonym: "spliceosomal catalysis" EXACT [] xref: GO:0000385 xref: GO:0031202 xref: Reactome:160901 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0004639 name: POZ domain binding namespace: molecular_function def: "Interacting selectively with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847] xref: GO:0031208 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004640 name: phosphatidylcholine binding namespace: molecular_function def: "Interacting selectively with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0031210 is_a: CCO:F0001666 ! phospholipid binding [Term] id: CCO:F0004641 name: neopullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pullulan to panose (6-a-D-glucosylmaltose)." [EC:3.2.1.135, GOC:mlg] synonym: "pullulan 4-D-glucanohydrolase (panose-forming)" EXACT [EC:3.2.1.135] synonym: "pullulanase II activity" EXACT [] xref: EC:3.2.1.135 xref: GO:0031216 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0004642 name: glucan 1,4-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-linkages in 1,4-beta-D-glucans, to remove successive glucose units." [EC:3.2.1.74, GOC:mlg] synonym: "1,4-beta-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.74] synonym: "beta-1,4-beta-glucanase activity" EXACT [EC:3.2.1.74] synonym: "beta-1,4-glucanase activity" EXACT [] synonym: "exo-1,4-beta-D-glucosidase activity" EXACT [EC:3.2.1.74] synonym: "exo-1,4-beta-glucanase activity" EXACT [] synonym: "exo-1,4-beta-glucosidase activity" EXACT [] synonym: "exo-beta-1,4-glucanase activity" EXACT [] synonym: "exo-beta-1,4-glucosidase activity" EXACT [] synonym: "exocellulase activity" EXACT [] xref: EC:3.2.1.74 xref: GO:0031217 is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0004643 name: arabinogalactan endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-galactosidic linkages in arabinogalactans." [EC:3.2.1.89, GOC:mlg] synonym: "arabinogalactan 4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.89] synonym: "arabinogalactanase activity" EXACT [] synonym: "endo-1,4-beta-galactanase activity" EXACT [] synonym: "galactanase activity" EXACT [] xref: EC:3.2.1.89 xref: GO:0031218 is_a: CCO:F0003368 ! hydrolase activity, acting on glycosyl bonds [Term] id: CCO:F0004644 name: levanase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units." [EC:3.2.1.65, GOC:mlg] synonym: "2,6-beta-D-fructan fructanohydrolase activity" EXACT [EC:3.2.1.65] synonym: "levan hydrolase activity" EXACT [] xref: EC:3.2.1.65 xref: GO:0031219 is_a: CCO:F0003368 ! hydrolase activity, acting on glycosyl bonds [Term] id: CCO:F0004645 name: maltodextrin phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846] xref: GO:0031220 is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0004646 name: denatured protein binding namespace: molecular_function def: "Interacting selectively with denatured proteins." [GOC:mlg] comment: Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates. xref: GO:0031249 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004647 name: amine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in)." [GOC:mlg] subset: gosubset_prok synonym: "amine ABC transporter" NARROW [] xref: GO:0031263 is_a: CCO:F0001529 ! amine transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0004648 name: small GTPase binding namespace: molecular_function def: "Interacting selectively with a small monomeric GTPase." [GOC:mah] xref: GO:0031267 is_a: CCO:F0008038 ! GTPase binding [Term] id: CCO:F0004649 name: alpha-1,2-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage." [PMID:7522655] xref: EC:2.4.1.- xref: GO:0031278 is_a: CCO:F0001853 ! galactosyltransferase activity [Term] id: CCO:F0004650 name: taurine-pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde." [EC:2.6.1.77] synonym: "taurine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.77] synonym: "Tpa" RELATED [EC:2.6.1.77] xref: EC:2.6.1.77 xref: GO:0031299 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0004651 name: hexitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [GOC:mah] subset: gosubset_prok xref: GO:0031320 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0004652 name: Pro-X metallocarboxypeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [EC:3.4.17.16, GOC:mah] synonym: "carboxypeptidase P activity" NARROW [EC:3.4.17.16] synonym: "membrane Pro-X carboxypeptidase activity" NARROW [EC:3.4.17.16] synonym: "membrane Pro-Xaa carboxypeptidase" NARROW [] synonym: "microsomal carboxypeptidase activity" NARROW [EC:3.4.17.16] xref: EC:3.4.17.16 xref: GO:0031368 is_a: CCO:F0000650 ! metallocarboxypeptidase activity is_a: CCO:F0001834 ! Pro-X carboxypeptidase activity [Term] id: CCO:F0004653 name: translation initiation factor binding namespace: molecular_function def: "Interacting selectively with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] xref: GO:0031369 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004654 name: eukaryotic initiation factor 4G binding namespace: molecular_function def: "Interacting selectively with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] synonym: "eIF4G binding" EXACT [] xref: GO:0031370 is_a: CCO:F0004653 ! translation initiation factor binding [Term] id: CCO:F0004655 name: protein tag namespace: molecular_function def: "Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators] subset: goslim_generic subset: goslim_pir synonym: "protein tagging activity" RELATED [] synonym: "ubiquitin" RELATED [] xref: GO:0031386 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0004656 name: sodium ion binding namespace: molecular_function def: "Interacting selectively with sodium ions (Na+)." [GOC:mah] subset: gosubset_prok xref: GO:0031402 is_a: CCO:F0004664 ! alkali metal ion binding [Term] id: CCO:F0004657 name: lithium ion binding namespace: molecular_function def: "Interacting selectively with lithium ions (Li+)." [GOC:mah] subset: gosubset_prok xref: GO:0031403 is_a: CCO:F0004664 ! alkali metal ion binding [Term] id: CCO:F0004658 name: chloride ion binding namespace: molecular_function def: "Interacting selectively with chloride ions (Cl-)." [GOC:mah] subset: gosubset_prok synonym: "chloride binding" EXACT [] xref: GO:0031404 is_a: CCO:F0005807 ! anion binding [Term] id: CCO:F0004659 name: lipoic acid binding namespace: molecular_function def: "Interacting selectively with lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0031405 is_a: CCO:F0004660 ! carboxylic acid binding is_a: CCO:F0007988 ! coenzyme binding [Term] id: CCO:F0004660 name: carboxylic acid binding namespace: molecular_function def: "Interacting selectively with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok xref: GO:0031406 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0004661 name: pigment binding namespace: molecular_function def: "Interacting selectively with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] subset: goslim_pir subset: gosubset_prok xref: GO:0031409 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0004662 name: L-ascorbic acid binding namespace: molecular_function def: "Interacting selectively with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, GOC:mah] synonym: "L-ascorbate binding" EXACT [] synonym: "vitamin C binding" EXACT [] xref: GO:0031418 is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0004663 name: cobalamin binding namespace: molecular_function def: "Interacting lelectively with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] synonym: "vitamin B12 binding" EXACT [] xref: GO:0031419 is_a: CCO:F0004191 ! vitamin binding [Term] id: CCO:F0004664 name: alkali metal ion binding namespace: molecular_function def: "Interacting selectively with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah] subset: gosubset_prok xref: GO:0031420 is_a: CCO:F0005808 ! cation binding is_a: CCO:F0006257 ! metal ion binding [Term] id: CCO:F0004665 name: hexon binding namespace: molecular_function def: "Interacting selectively with a hexon, the major protein component of the icosahedral capsid of an adenovirus." [GOC:mah, PMID:12915569] xref: GO:0031423 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004666 name: titin binding namespace: molecular_function def: "Interacting selectively with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively." [GOC:mah, PMID:10481174] xref: GO:0031432 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0004667 name: telethonin binding namespace: molecular_function def: "Interacting selectively with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase." [GOC:mah, PMID:10481174] xref: GO:0031433 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0004668 name: mitogen-activated protein kinase kinase binding namespace: molecular_function def: "Interacting selectively with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase." [GOC:mah] synonym: "MAPKK binding" EXACT [] xref: GO:0031434 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0004669 name: mitogen-activated protein kinase kinase kinase binding namespace: molecular_function def: "Interacting selectively with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [GOC:bf] synonym: "MAPKKK binding" EXACT [] xref: GO:0031435 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0004670 name: betaine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)." [GOC:mlg] synonym: "betaine ABC transporter" NARROW [] xref: GO:0031458 is_a: CCO:F0004647 ! amine-transporting ATPase activity [Term] id: CCO:F0004671 name: glycine betaine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)." [GOC:mlg] synonym: "glycine betaine ABC transporter" NARROW [] synonym: "N-trimethylglycine-transporting ATPase activity" EXACT [] xref: GO:0031459 is_a: CCO:F0004670 ! betaine-transporting ATPase activity [Term] id: CCO:F0004672 name: myosin III binding namespace: molecular_function def: "Interacting selectively with a class III myosin; myosin III is monomeric and has an N terminal kinase domain." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031473 is_a: CCO:F0003516 ! myosin binding [Term] id: CCO:F0004673 name: myosin V binding namespace: molecular_function def: "Interacting selectively with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0031489 is_a: CCO:F0003516 ! myosin binding [Term] id: CCO:F0004674 name: chromatin DNA binding namespace: molecular_function def: "Interacting selectively with DNA that is assembled into chromatin." [GOC:mah] xref: GO:0031490 is_a: CCO:F0000278 ! chromatin binding is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0004675 name: nucleosome binding namespace: molecular_function def: "Interacting selectively with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] xref: GO:0031491 is_a: CCO:F0000278 ! chromatin binding [Term] id: CCO:F0004676 name: nucleosomal DNA binding namespace: molecular_function def: "Interacting selectively with the DNA portion of a nucleosome." [GOC:mah] xref: GO:0031492 is_a: CCO:F0004674 ! chromatin DNA binding is_a: CCO:F0004675 ! nucleosome binding [Term] id: CCO:F0004677 name: nucleosomal histone binding namespace: molecular_function def: "Interacting selectively with a histone that is assembled into a nucleosome." [GOC:mah] xref: GO:0031493 is_a: CCO:F0004675 ! nucleosome binding is_a: CCO:F0005669 ! histone binding [Term] id: CCO:F0004678 name: far-red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation." [GOC:nln] xref: GO:0031516 is_a: CCO:F0002412 ! red or far-red light photoreceptor activity [Term] id: CCO:F0004679 name: red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation." [GOC:nln] xref: GO:0031517 is_a: CCO:F0002412 ! red or far-red light photoreceptor activity [Term] id: CCO:F0004680 name: gonadotropin-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively with a receptor for gonadotropin-releasing hormone, a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." [PMID:15196882] xref: GO:0031530 is_a: CCO:F0008110 ! peptide hormone receptor binding [Term] id: CCO:F0004681 name: thyrotropin-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary." [PMID:8592728] synonym: "thyrotropin-releasing hormone receptor ligand" NARROW [] xref: GO:0031531 xref: GO:0031888 is_a: CCO:F0000196 ! G-protein-coupled receptor binding is_a: CCO:F0008110 ! peptide hormone receptor binding [Term] id: CCO:F0004682 name: peptidyl-proline dioxygenase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein." [GOC:mah] xref: GO:0031543 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0004683 name: peptidyl-proline 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [GOC:mah] xref: GO:0031544 is_a: CCO:F0004682 ! peptidyl-proline dioxygenase activity [Term] id: CCO:F0004684 name: peptidyl-proline 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [GOC:mah] synonym: "HIF-type prolyl 4-hydroxylase" NARROW [] synonym: "prolyl 4-hydroxylase" BROAD [] xref: GO:0031545 is_a: CCO:F0004682 ! peptidyl-proline dioxygenase activity [Term] id: CCO:F0004685 name: brain-derived neurotrophic factor receptor binding namespace: molecular_function def: "Interacting selectively with the brain-derived neurotrophic factor receptor." [GOC:mah] synonym: "BDNF receptor binding" EXACT [] synonym: "brain-derived neurotrophic factor ligand" NARROW [] xref: GO:0031546 is_a: CCO:F0001466 ! neurotrophin receptor binding [Term] id: CCO:F0004686 name: oxidosqualene cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of (S)-2,3-epoxysqualene to triterpene." [GOC:ct] subset: gosubset_prok xref: GO:0031559 is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0004687 name: polyubiquitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polymer of ubiqutin." [GOC:mah] synonym: "multiubiquitin binding" RELATED [] xref: GO:0031593 is_a: CCO:F0005797 ! ubiquitin binding [Term] id: CCO:F0004688 name: ubiquitin conjugating enzyme binding namespace: molecular_function def: "Interacting selectively with a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp] xref: GO:0031624 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0004689 name: ubiquitin protein ligase binding namespace: molecular_function def: "Interacting selectively with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] synonym: "ubiquitin ligase binding" EXACT [] xref: GO:0031625 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0004690 name: beta-endorphin binding namespace: molecular_function def: "Interacting selectively with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin." [GOC:nln, PMID:6267560] xref: GO:0031626 is_a: CCO:F0005633 ! neurotransmitter binding [Term] id: CCO:F0004691 name: opioid receptor binding namespace: molecular_function def: "Interacting selectively with an opioid receptor." [GOC:nln] xref: GO:0031628 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004692 name: replication fork barrier binding namespace: molecular_function def: "Interacting selectively with replication fork barriers, sites that inhibit the progress of replication forks." [GOC:mah] xref: GO:0031634 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0004693 name: adrenocorticotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with adrenocorticotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] xref: GO:0031636 is_a: CCO:F0003530 ! adrenocorticotropin-releasing hormone binding [Term] id: CCO:F0004694 name: NADH dehydrogenase (plastoquinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol." [EC:1.6.99.6, GOC:mah] synonym: "NADH:plastoquinone reductase activity" EXACT [] xref: GO:0030024 xref: GO:0031679 is_a: CCO:F0007489 ! NADH dehydrogenase (quinone) activity [Term] id: CCO:F0004695 name: G-protein beta-subunit binding namespace: molecular_function def: "Interacting selectively with a G-protein beta subunit." [GOC:mah] synonym: "G-beta protein subunit binding" EXACT [] xref: GO:0031681 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004696 name: G-protein gamma-subunit binding namespace: molecular_function def: "Interacting selectively with a G-protein gamma subunit." [GOC:mah] synonym: "G-gamma protein subunit binding" EXACT [] xref: GO:0031682 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004697 name: G-protein beta/gamma-subunit binding namespace: molecular_function def: "Interacting selectively with a complex of G-protein beta/gamma subunits." [GOC:nln] xref: GO:0031683 is_a: CCO:F0004983 ! protein complex binding [Term] id: CCO:F0004698 name: adenosine receptor binding namespace: molecular_function def: "Interacting selectively with an adenosine receptor." [GOC:mah, GOC:nln] synonym: "adenosine receptor ligand" NARROW [] xref: GO:0031685 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004699 name: A1 adenosine receptor binding namespace: molecular_function def: "Interacting selectively with an A1 adenosine receptor." [GOC:mah, GOC:nln] synonym: "A1 adenosine receptor ligand" NARROW [] xref: GO:0031686 is_a: CCO:F0004698 ! adenosine receptor binding [Term] id: CCO:F0004700 name: A2A adenosine receptor binding namespace: molecular_function def: "Interacting selectively with an A2A adenosine receptor." [GOC:mah, GOC:nln] synonym: "A2A adenosine receptor ligand" NARROW [] xref: GO:0031687 is_a: CCO:F0004698 ! adenosine receptor binding [Term] id: CCO:F0004701 name: A2B adenosine receptor binding namespace: molecular_function def: "Interacting selectively with an A2B adenosine receptor." [GOC:mah, GOC:nln] synonym: "A2B adenosine receptor ligand" NARROW [] xref: GO:0031688 is_a: CCO:F0004698 ! adenosine receptor binding [Term] id: CCO:F0004702 name: A3 adenosine receptor binding namespace: molecular_function def: "Interacting selectively with an A3 adenosine receptor." [GOC:mah, GOC:nln] synonym: "A3 adenosine receptor ligand" NARROW [] xref: GO:0031689 is_a: CCO:F0004698 ! adenosine receptor binding [Term] id: CCO:F0004703 name: adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with an adrenergic receptor." [GOC:mah, GOC:nln] synonym: "adrenergic receptor ligand" NARROW [] xref: GO:0031690 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004704 name: alpha-1A adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with an alpha-1A adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1A adrenergic receptor ligand" NARROW [] xref: GO:0031691 is_a: CCO:F0004703 ! adrenergic receptor binding [Term] id: CCO:F0004705 name: alpha-1B adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with an alpha-1B adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1B adrenergic receptor ligand" NARROW [] xref: GO:0031692 is_a: CCO:F0004703 ! adrenergic receptor binding [Term] id: CCO:F0004706 name: alpha-1D adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with an alpha-1D adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1D adrenergic receptor ligand" NARROW [] xref: GO:0031693 is_a: CCO:F0004703 ! adrenergic receptor binding [Term] id: CCO:F0004707 name: alpha-2A adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with an alpha-2A adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2A adrenergic receptor ligand" NARROW [] xref: GO:0031694 is_a: CCO:F0004703 ! adrenergic receptor binding [Term] id: CCO:F0004708 name: alpha-2B adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with an alpha-2B adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2B adrenergic receptor ligand" NARROW [] xref: GO:0031695 is_a: CCO:F0004703 ! adrenergic receptor binding [Term] id: CCO:F0004709 name: alpha-2C adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with an alpha-2C adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2C adrenergic receptor ligand" NARROW [] xref: GO:0031696 is_a: CCO:F0004703 ! adrenergic receptor binding [Term] id: CCO:F0004710 name: beta-1 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with a beta-1 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-1 adrenergic receptor ligand" NARROW [] xref: GO:0031697 is_a: CCO:F0004703 ! adrenergic receptor binding [Term] id: CCO:F0004711 name: beta-2 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with a beta-2 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-2 adrenergic receptor ligand" NARROW [] xref: GO:0031698 is_a: CCO:F0004703 ! adrenergic receptor binding [Term] id: CCO:F0004712 name: beta-3 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively with a beta-3 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-3 adrenergic receptor ligand" NARROW [] xref: GO:0031699 is_a: CCO:F0004703 ! adrenergic receptor binding [Term] id: CCO:F0004713 name: adrenomedullin receptor binding namespace: molecular_function def: "Interacting selectively with an adrenomedullin receptor." [GOC:mah, GOC:nln] synonym: "adrenomedullin receptor ligand" NARROW [] xref: GO:0031700 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004714 name: angiotensin receptor binding namespace: molecular_function def: "Interacting selectively with an angiotensin receptor." [GOC:mah, GOC:nln] synonym: "angiotensin receptor ligand" NARROW [] xref: GO:0031701 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004715 name: type 1 angiotensin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 angiotensin receptor." [GOC:mah, GOC:nln] synonym: "AT1 receptor binding" EXACT [] synonym: "type 1 angiotensin receptor ligand" NARROW [] xref: GO:0031702 is_a: CCO:F0004714 ! angiotensin receptor binding [Term] id: CCO:F0004716 name: type 2 angiotensin receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 angiotensin receptor." [GOC:mah, GOC:nln] synonym: "AT2 receptor binding" EXACT [] synonym: "type 2 angiotensin receptor ligand" NARROW [] xref: GO:0031703 is_a: CCO:F0004714 ! angiotensin receptor binding [Term] id: CCO:F0004717 name: apelin receptor binding namespace: molecular_function def: "Interacting selectively with an apelin receptor." [GOC:mah, GOC:nln, GOC:vp, PMID:12787050] synonym: "apelin receptor ligand" NARROW [] synonym: "APJ receptor binding" EXACT [] xref: GO:0031704 xref: GO:0042569 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004718 name: bombesin receptor binding namespace: molecular_function def: "Interacting selectively with a bombesin receptor." [GOC:mah, GOC:nln] synonym: "bombesin receptor ligand" NARROW [] xref: GO:0031705 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004719 name: subtype 3 bombesin receptor binding namespace: molecular_function def: "Interacting selectively with a subtype 3 bombesin receptor." [GOC:mah, GOC:nln] synonym: "subtype 3 bombesin receptor ligand" NARROW [] xref: GO:0031706 is_a: CCO:F0004718 ! bombesin receptor binding [Term] id: CCO:F0004720 name: endothelin A receptor binding namespace: molecular_function def: "Interacting selectively with an endothelin A receptor." [GOC:mah, GOC:nln] synonym: "endothelin A receptor ligand" NARROW [] synonym: "endothelin-1 receptor binding" EXACT [] xref: GO:0031707 is_a: CCO:F0004718 ! bombesin receptor binding [Term] id: CCO:F0004721 name: endothelin B receptor binding namespace: molecular_function def: "Interacting selectively with an endothelin B receptor." [GOC:mah, GOC:nln] synonym: "endothelin B receptor ligand" NARROW [] xref: GO:0031708 is_a: CCO:F0004718 ! bombesin receptor binding [Term] id: CCO:F0004722 name: gastrin-releasing peptide receptor binding namespace: molecular_function def: "Interacting selectively with a gastrin-releasing peptide receptor." [GOC:mah, GOC:nln] synonym: "gastrin-releasing peptide receptor ligand" NARROW [] synonym: "GRP receptor binding" EXACT [] xref: GO:0031709 is_a: CCO:F0004718 ! bombesin receptor binding [Term] id: CCO:F0004723 name: neuromedin B receptor binding namespace: molecular_function def: "Interacting selectively with a neuromedin B receptor." [GOC:mah, GOC:nln] synonym: "neuromedin B receptor ligand" NARROW [] xref: GO:0031710 is_a: CCO:F0004718 ! bombesin receptor binding [Term] id: CCO:F0004724 name: bradykinin receptor binding namespace: molecular_function def: "Interacting selectively with a bradykinin receptor." [GOC:mah, GOC:nln] synonym: "bradykinin receptor ligand" NARROW [] xref: GO:0031711 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004725 name: B1 bradykinin receptor binding namespace: molecular_function def: "Interacting selectively with a B1 bradykinin receptor." [GOC:mah, GOC:nln] synonym: "B1 bradykinin receptor ligand" NARROW [] xref: GO:0031712 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004726 name: B2 bradykinin receptor binding namespace: molecular_function def: "Interacting selectively with a B2 bradykinin receptor." [GOC:mah, GOC:nln] synonym: "B2 bradykinin receptor ligand" NARROW [] xref: GO:0031713 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004727 name: C5a anaphylatoxin chemotactic receptor binding namespace: molecular_function def: "Interacting selectively with a C5a anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] synonym: "C5a anaphylatoxin chemotactic receptor ligand" NARROW [] xref: GO:0031714 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004728 name: C5L2 anaphylatoxin chemotactic receptor binding namespace: molecular_function def: "Interacting selectively with a C5L2 anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] synonym: "C5L2 anaphylatoxin chemotactic receptor ligand" NARROW [] xref: GO:0031715 is_a: CCO:F0004727 ! C5a anaphylatoxin chemotactic receptor binding [Term] id: CCO:F0004729 name: calcitonin receptor binding namespace: molecular_function def: "Interacting selectively with a calcitonin receptor." [GOC:mah, GOC:nln] synonym: "calcitonin receptor ligand" NARROW [] xref: GO:0031716 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004730 name: cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively with a cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "cannabinoid receptor ligand" NARROW [] xref: GO:0031717 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004731 name: type 1 cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "type 1 cannabinoid receptor ligand" NARROW [] xref: GO:0031718 is_a: CCO:F0004730 ! cannabinoid receptor binding [Term] id: CCO:F0004732 name: type 2 cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "type 2 cannabinoid receptor ligand" NARROW [] xref: GO:0031719 is_a: CCO:F0004730 ! cannabinoid receptor binding [Term] id: CCO:F0004733 name: haptoglobin binding namespace: molecular_function def: "Interacting selectively with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0031720 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004734 name: hemoglobin alpha binding namespace: molecular_function def: "Interacting selectively with a hemoglobin alpha chain." [GOC:mah] xref: GO:0031721 is_a: CCO:F0004445 ! hemoglobin binding [Term] id: CCO:F0004735 name: hemoglobin beta binding namespace: molecular_function def: "Interacting selectively with a hemoglobin beta chain." [GOC:mah] xref: GO:0031722 is_a: CCO:F0004445 ! hemoglobin binding [Term] id: CCO:F0004736 name: CXCR4 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CXCR4 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CXCR4 chemokine receptor ligand" NARROW [] synonym: "stromal cell-derived factor 1 receptor binding" EXACT [] xref: GO:0031723 is_a: CCO:F0006097 ! CXCR chemokine receptor binding [Term] id: CCO:F0004737 name: CXCR5 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CXCR5 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CXCR5 chemokine receptor ligand" NARROW [] synonym: "type 1 Burkitt's lymphoma receptor binding" EXACT [] xref: GO:0031724 is_a: CCO:F0006097 ! CXCR chemokine receptor binding [Term] id: CCO:F0004738 name: CXCR6 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CXCR6 chemokine receptor." [GOC:mah, GOC:nln] synonym: "bonzo receptor binding" EXACT [] synonym: "CXCR6 chemokine receptor ligand" NARROW [] synonym: "STRL33 receptor binding" EXACT [] xref: GO:0031725 is_a: CCO:F0006097 ! CXCR chemokine receptor binding [Term] id: CCO:F0004739 name: CCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR1 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR1 chemokine receptor ligand" NARROW [] synonym: "macrophage inflammatory protein-1 alpha receptor binding" EXACT [] xref: GO:0031726 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004740 name: CCR2 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR2 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR2 chemokine receptor ligand" NARROW [] synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT [] xref: GO:0031727 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004741 name: CCR3 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR3 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR3 chemokine receptor ligand" NARROW [] synonym: "eosinophil eotaxin receptor binding" EXACT [] xref: GO:0031728 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004742 name: CCR4 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR4 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR4 chemokine receptor ligand" NARROW [] xref: GO:0031729 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004743 name: CCR5 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR5 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR5 chemokine receptor ligand" NARROW [] xref: GO:0031730 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004744 name: CCR6 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR6 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR6 chemokine receptor ligand" NARROW [] synonym: "LARC receptor binding" EXACT [] xref: GO:0031731 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004745 name: CCR7 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR7 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR7 chemokine receptor ligand" NARROW [] synonym: "MIP-3 beta receptor binding" EXACT [] synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT [] xref: GO:0031732 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004746 name: CCR8 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR8 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR8 chemokine receptor ligand" NARROW [] xref: GO:0031733 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004747 name: CCR9 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR9 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR9 chemokine receptor ligand" NARROW [] xref: GO:0031734 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004748 name: CCR10 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR10 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR10 chemokine receptor ligand" NARROW [] xref: GO:0031735 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004749 name: CCR11 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR11 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR11 chemokine receptor ligand" NARROW [] xref: GO:0031736 is_a: CCO:F0007302 ! CCR chemokine receptor binding [Term] id: CCO:F0004750 name: CX3C chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CX3C chemokine receptor." [GOC:mah, GOC:nln] synonym: "CX3C chemokine receptor ligand" NARROW [] synonym: "fractalkine receptor binding" EXACT [] xref: GO:0031737 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004751 name: XCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a XCR1 chemokine receptor." [GOC:mah, GOC:nln] synonym: "lymphotactin receptor binding" EXACT [] synonym: "XCR1 chemokine receptor ligand" NARROW [] xref: GO:0031738 is_a: CCO:F0005665 ! chemokine receptor binding [Term] id: CCO:F0004752 name: cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively with a cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "cholecystokinin receptor ligand" NARROW [] xref: GO:0031739 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004753 name: type A cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively with a type A cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "type A cholecystokinin receptor ligand" NARROW [] xref: GO:0031740 is_a: CCO:F0004752 ! cholecystokinin receptor binding [Term] id: CCO:F0004754 name: type B gastrin/cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively with a type B gastrin/cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "type B gastrin/cholecystokinin receptor ligand" NARROW [] xref: GO:0031741 is_a: CCO:F0004752 ! cholecystokinin receptor binding [Term] id: CCO:F0004755 name: corticotropin releasing factor receptor binding namespace: molecular_function def: "Interacting selectively with a corticotropin releasing factor receptor." [GOC:mah, GOC:nln] synonym: "corticotropin releasing factor receptor ligand" NARROW [] xref: GO:0031742 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004756 name: type 1 corticotropin releasing factor receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 corticotropin releasing factor receptor." [GOC:mah, GOC:nln] synonym: "type 1 corticotropin releasing factor receptor ligand" NARROW [] xref: GO:0031743 is_a: CCO:F0004755 ! corticotropin releasing factor receptor binding [Term] id: CCO:F0004757 name: type 2 corticotropin releasing factor receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 corticotropin releasing factor receptor." [GOC:mah, GOC:nln] synonym: "type 2 corticotropin releasing factor receptor ligand" NARROW [] xref: GO:0031744 is_a: CCO:F0004755 ! corticotropin releasing factor receptor binding [Term] id: CCO:F0004758 name: cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively with a cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "cysteinyl leukotriene receptor ligand" NARROW [] xref: GO:0031745 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004759 name: type 1 cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "type 1 cysteinyl leukotriene receptor ligand" NARROW [] xref: GO:0031746 is_a: CCO:F0004758 ! cysteinyl leukotriene receptor binding [Term] id: CCO:F0004760 name: type 2 cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "type 2 cysteinyl leukotriene receptor ligand" NARROW [] xref: GO:0031747 is_a: CCO:F0004758 ! cysteinyl leukotriene receptor binding [Term] id: CCO:F0004761 name: D1 dopamine receptor binding namespace: molecular_function def: "Interacting selectively with a D1 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D1 dopamine receptor ligand" NARROW [] synonym: "D1A dopamine receptor binding" EXACT [] xref: GO:0031748 is_a: CCO:F0008009 ! dopamine receptor binding [Term] id: CCO:F0004762 name: D2 dopamine receptor binding namespace: molecular_function def: "Interacting selectively with a D2 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D2 dopamine receptor ligand" NARROW [] xref: GO:0031749 is_a: CCO:F0008009 ! dopamine receptor binding [Term] id: CCO:F0004763 name: D3 dopamine receptor binding namespace: molecular_function def: "Interacting selectively with a D3 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D3 dopamine receptor ligand" NARROW [] xref: GO:0031750 is_a: CCO:F0008009 ! dopamine receptor binding [Term] id: CCO:F0004764 name: D4 dopamine receptor binding namespace: molecular_function def: "Interacting selectively with a D4 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D4 dopamine receptor ligand" NARROW [] xref: GO:0031751 is_a: CCO:F0008009 ! dopamine receptor binding [Term] id: CCO:F0004765 name: D5 dopamine receptor binding namespace: molecular_function def: "Interacting selectively with a D5 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D1B dopamine receptor binding" EXACT [] synonym: "D5 dopamine receptor ligand" NARROW [] xref: GO:0031752 is_a: CCO:F0008009 ! dopamine receptor binding [Term] id: CCO:F0004766 name: endothelial differentiation G-protein coupled receptor binding namespace: molecular_function def: "Interacting selectively with an endothelial differentiation G-protein coupled receptor." [GOC:mah, GOC:nln] synonym: "endothelial differentiation G-protein coupled receptor ligand" NARROW [] xref: GO:0031753 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004767 name: Edg-1 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively with an Edg-1 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-1 sphingosine 1-phosphate receptor ligand" NARROW [] xref: GO:0031754 is_a: CCO:F0004766 ! endothelial differentiation G-protein coupled receptor binding [Term] id: CCO:F0004768 name: Edg-2 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively with an Edg-2 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-2 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA1 receptor binding" EXACT [] xref: GO:0031755 is_a: CCO:F0004766 ! endothelial differentiation G-protein coupled receptor binding [Term] id: CCO:F0004769 name: Edg-3 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively with an Edg-3 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-3 sphingosine 1-phosphate receptor ligand" NARROW [] xref: GO:0031756 is_a: CCO:F0004766 ! endothelial differentiation G-protein coupled receptor binding [Term] id: CCO:F0004770 name: Edg-4 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively with an Edg-4 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-4 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA2 receptor binding" EXACT [] xref: GO:0031757 is_a: CCO:F0004766 ! endothelial differentiation G-protein coupled receptor binding [Term] id: CCO:F0004771 name: Edg-5 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively with an Edg-5 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-5 sphingosine 1-phosphate receptor ligand" NARROW [] xref: GO:0031758 is_a: CCO:F0004766 ! endothelial differentiation G-protein coupled receptor binding [Term] id: CCO:F0004772 name: Edg-6 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively with an Edg-6 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-6 sphingosine 1-phosphate receptor ligand" NARROW [] xref: GO:0031759 is_a: CCO:F0004766 ! endothelial differentiation G-protein coupled receptor binding [Term] id: CCO:F0004773 name: Edg-7 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively with an Edg-7 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-7 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA3 receptor binding" EXACT [] xref: GO:0031760 is_a: CCO:F0004766 ! endothelial differentiation G-protein coupled receptor binding [Term] id: CCO:F0004774 name: fMet-Leu-Phe receptor binding namespace: molecular_function def: "Interacting selectively with a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln] synonym: "fMet-Leu-Phe receptor ligand" NARROW [] synonym: "N-formyl peptide receptor binding" EXACT [] xref: GO:0031761 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004775 name: follicle stimulating hormone receptor binding namespace: molecular_function def: "Interacting selectively with a follicle stimulating hormone receptor." [GOC:mah, GOC:nln] synonym: "follicle stimulating hormone receptor ligand" NARROW [] xref: GO:0031762 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004776 name: galanin receptor binding namespace: molecular_function def: "Interacting selectively with a galanin receptor." [GOC:mah, GOC:nln] synonym: "galanin receptor ligand" NARROW [] xref: GO:0031763 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004777 name: type 1 galanin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 1 galanin receptor ligand" NARROW [] xref: GO:0031764 is_a: CCO:F0004776 ! galanin receptor binding [Term] id: CCO:F0004778 name: type 2 galanin receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 2 galanin receptor ligand" NARROW [] xref: GO:0031765 is_a: CCO:F0004776 ! galanin receptor binding [Term] id: CCO:F0004779 name: type 3 galanin receptor binding namespace: molecular_function def: "Interacting selectively with a type 3 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 3 galanin receptor ligand" NARROW [] xref: GO:0031766 is_a: CCO:F0004776 ! galanin receptor binding [Term] id: CCO:F0004780 name: gastric inhibitory polypeptide receptor binding namespace: molecular_function def: "Interacting selectively with a gastric inhibitory polypeptide receptor." [GOC:mah, GOC:nln] synonym: "gastric inhibitory polypeptide receptor ligand" NARROW [] xref: GO:0031767 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004781 name: ghrelin receptor binding namespace: molecular_function def: "Interacting selectively with a ghrelin receptor." [GOC:mah, GOC:nln] synonym: "ghrelin receptor ligand" NARROW [] synonym: "type 1 growth hormone secretagogue GH-releasing peptide receptor binding" EXACT [] xref: GO:0031768 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004782 name: glucagon receptor binding namespace: molecular_function def: "Interacting selectively with a glucagon receptor." [GOC:mah, GOC:nln] synonym: "glucagon receptor ligand" NARROW [] xref: GO:0031769 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004783 name: growth hormone-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively with a growth hormone-releasing hormone receptor." [GOC:mah, GOC:nln] synonym: "growth hormone-releasing hormone receptor ligand" NARROW [] xref: GO:0031770 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004784 name: type 1 hypocretin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 hypocretin receptor." [GOC:mah, GOC:nln] synonym: "type 1 hypocretin receptor ligand" NARROW [] synonym: "type 1 orexin receptor binding" EXACT [] xref: GO:0031771 is_a: CCO:F0005660 ! hypocretin receptor binding [Term] id: CCO:F0004785 name: type 2 hypocretin receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 hypocretin receptor." [GOC:mah, GOC:nln] synonym: "type 2 hypocretin receptor ligand" NARROW [] synonym: "type 2 orexin receptor binding" EXACT [] xref: GO:0031772 is_a: CCO:F0005660 ! hypocretin receptor binding [Term] id: CCO:F0004786 name: kisspeptin receptor binding namespace: molecular_function def: "Interacting selectively with a kisspeptin receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled receptor 54 binding" EXACT [] synonym: "hOT7T175 receptor binding" EXACT [] synonym: "hypogonadotropin-1 receptor binding" EXACT [] synonym: "KiSS-1 receptor binding" EXACT [] synonym: "kisspeptin receptor ligand" NARROW [] synonym: "metastin receptor binding" EXACT [] xref: GO:0031773 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004787 name: leukotriene receptor binding namespace: molecular_function def: "Interacting selectively with a leukotriene receptor." [GOC:mah, GOC:nln] synonym: "leukotriene receptor ligand" NARROW [] xref: GO:0031774 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004788 name: lutropin-choriogonadotropic hormone receptor binding namespace: molecular_function def: "Interacting selectively with a lutropin-choriogonadotropic hormone receptor." [GOC:mah, GOC:nln] synonym: "lutropin-choriogonadotropic hormone receptor ligand" NARROW [] xref: GO:0031775 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004789 name: melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively with a melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "melanin-concentrating hormone receptor ligand" NARROW [] xref: GO:0031776 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004790 name: type 1 melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "type 1 melanin-concentrating hormone receptor ligand" NARROW [] xref: GO:0031777 is_a: CCO:F0004789 ! melanin-concentrating hormone receptor binding [Term] id: CCO:F0004791 name: type 2 melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "type 2 melanin-concentrating hormone receptor ligand" NARROW [] xref: GO:0031778 is_a: CCO:F0004789 ! melanin-concentrating hormone receptor binding [Term] id: CCO:F0004792 name: melanocortin receptor binding namespace: molecular_function def: "Interacting selectively with a melanocortin receptor." [GOC:mah, GOC:nln] synonym: "melanocortin receptor ligand" NARROW [] xref: GO:0031779 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004793 name: adrenocorticotropin hormone receptor binding namespace: molecular_function def: "Interacting selectively with an adrenocorticotropin hormone receptor." [GOC:dph, GOC:mah, GOC:nln] synonym: "ACTH receptor binding" EXACT [] synonym: "adrenocorticotropic hormone receptor ligand" NARROW [] xref: GO:0031780 is_a: CCO:F0004792 ! melanocortin receptor binding [Term] id: CCO:F0004794 name: type 3 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively with a type 3 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 3 melanocortin receptor ligand" NARROW [] xref: GO:0031781 is_a: CCO:F0004792 ! melanocortin receptor binding [Term] id: CCO:F0004795 name: type 4 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively with a type 4 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 4 melanocortin receptor ligand" NARROW [] xref: GO:0031782 is_a: CCO:F0004792 ! melanocortin receptor binding [Term] id: CCO:F0004796 name: type 5 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively with a type 5 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 5 melanocortin receptor ligand" NARROW [] xref: GO:0031783 is_a: CCO:F0004792 ! melanocortin receptor binding [Term] id: CCO:F0004797 name: melatonin receptor binding namespace: molecular_function def: "Interacting selectively with a melatonin receptor." [GOC:mah, GOC:nln] synonym: "melatonin receptor ligand" NARROW [] xref: GO:0031784 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004798 name: type 1A melatonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1A melatonin receptor." [GOC:mah, GOC:nln] synonym: "type 1A melatonin receptor ligand" NARROW [] xref: GO:0031785 is_a: CCO:F0004797 ! melatonin receptor binding [Term] id: CCO:F0004799 name: type 1B melatonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1B melatonin receptor." [GOC:mah, GOC:nln] synonym: "type 1B melatonin receptor ligand" NARROW [] xref: GO:0031786 is_a: CCO:F0004797 ! melatonin receptor binding [Term] id: CCO:F0004800 name: H9 melatonin receptor binding namespace: molecular_function def: "Interacting selectively with a H9 melatonin receptor." [GOC:mah, GOC:nln] synonym: "H9 melatonin receptor ligand" NARROW [] xref: GO:0031787 is_a: CCO:F0004797 ! melatonin receptor binding [Term] id: CCO:F0004801 name: motilin receptor binding namespace: molecular_function def: "Interacting selectively with a motilin receptor." [GOC:mah, GOC:nln] synonym: "motilin receptor ligand" NARROW [] xref: GO:0031788 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004802 name: muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively with a muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "muscarinic acetylcholine receptor ligand" NARROW [] xref: GO:0031789 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004803 name: M1 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively with a M1 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M1 muscarinic acetylcholine receptor ligand" NARROW [] xref: GO:0031790 is_a: CCO:F0004802 ! muscarinic acetylcholine receptor binding [Term] id: CCO:F0004804 name: M2 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively with a M2 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M2 muscarinic acetylcholine receptor ligand" NARROW [] xref: GO:0031791 is_a: CCO:F0004802 ! muscarinic acetylcholine receptor binding [Term] id: CCO:F0004805 name: M3 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively with a M3 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M3 muscarinic acetylcholine receptor ligand" NARROW [] xref: GO:0031792 is_a: CCO:F0004802 ! muscarinic acetylcholine receptor binding [Term] id: CCO:F0004806 name: M4 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively with a M4 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M4 muscarinic acetylcholine receptor ligand" NARROW [] xref: GO:0031793 is_a: CCO:F0004802 ! muscarinic acetylcholine receptor binding [Term] id: CCO:F0004807 name: M5 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively with a M5 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M5 muscarinic acetylcholine receptor ligand" NARROW [] xref: GO:0031794 is_a: CCO:F0004802 ! muscarinic acetylcholine receptor binding [Term] id: CCO:F0004808 name: metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively with a metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "GABAB receptor binding" EXACT [] synonym: "metabotropic GABA receptor ligand" NARROW [] xref: GO:0031795 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004809 name: type 1 metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "type 1 metabotropic GABA receptor ligand" NARROW [] xref: GO:0031796 is_a: CCO:F0004808 ! metabotropic GABA receptor binding [Term] id: CCO:F0004810 name: type 2 metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "type 2 metabotropic GABA receptor ligand" NARROW [] xref: GO:0031797 is_a: CCO:F0004808 ! metabotropic GABA receptor binding [Term] id: CCO:F0004811 name: type 1 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 1 metabotropic glutamate receptor ligand" NARROW [] xref: GO:0031798 is_a: CCO:F0005584 ! metabotropic glutatmate receptor binding [Term] id: CCO:F0004812 name: type 2 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 2 metabotropic glutamate receptor ligand" NARROW [] xref: GO:0031799 is_a: CCO:F0005584 ! metabotropic glutatmate receptor binding [Term] id: CCO:F0004813 name: type 3 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively with a type 3 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 3 metabotropic glutamate receptor ligand" NARROW [] xref: GO:0031800 is_a: CCO:F0005584 ! metabotropic glutatmate receptor binding [Term] id: CCO:F0004814 name: type 4 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively with a type 4 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 4 metabotropic glutamate receptor ligand" NARROW [] xref: GO:0031801 is_a: CCO:F0005584 ! metabotropic glutatmate receptor binding [Term] id: CCO:F0004815 name: type 5 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively with a type 5 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 5 metabotropic glutamate receptor ligand" NARROW [] xref: GO:0031802 is_a: CCO:F0005584 ! metabotropic glutatmate receptor binding [Term] id: CCO:F0004816 name: type 6 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively with a type 6 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 6 metabotropic glutamate receptor ligand" NARROW [] xref: GO:0031803 is_a: CCO:F0005584 ! metabotropic glutatmate receptor binding [Term] id: CCO:F0004817 name: type 7 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively with a type 7 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 7 metabotropic glutamate receptor ligand" NARROW [] xref: GO:0031804 is_a: CCO:F0005584 ! metabotropic glutatmate receptor binding [Term] id: CCO:F0004818 name: type 8 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively with a type 8 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 8 metabotropic glutamate receptor ligand" NARROW [] xref: GO:0031805 is_a: CCO:F0005584 ! metabotropic glutatmate receptor binding [Term] id: CCO:F0004819 name: metabotropic histamine receptor binding namespace: molecular_function def: "Interacting selectively with a metabotropic histamine receptor." [GOC:mah, GOC:nln] synonym: "metabotropic histamine receptor ligand" NARROW [] xref: GO:0031806 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004820 name: H1 histamine receptor binding namespace: molecular_function def: "Interacting selectively with a H1 histamine receptor." [GOC:mah, GOC:nln] synonym: "H1 histamine receptor ligand" NARROW [] xref: GO:0031807 is_a: CCO:F0004819 ! metabotropic histamine receptor binding [Term] id: CCO:F0004821 name: H2 histamine receptor binding namespace: molecular_function def: "Interacting selectively with a H2 histamine receptor." [GOC:mah, GOC:nln] synonym: "H2 histamine receptor ligand" NARROW [] xref: GO:0031808 is_a: CCO:F0004819 ! metabotropic histamine receptor binding [Term] id: CCO:F0004822 name: H3 histamine receptor binding namespace: molecular_function def: "Interacting selectively with a H3 histamine receptor." [GOC:mah, GOC:nln] synonym: "H3 histamine receptor ligand" NARROW [] xref: GO:0031809 is_a: CCO:F0004819 ! metabotropic histamine receptor binding [Term] id: CCO:F0004823 name: H4 histamine receptor binding namespace: molecular_function def: "Interacting selectively with a H4 histamine receptor." [GOC:mah, GOC:nln] synonym: "H4 histamine receptor ligand" NARROW [] xref: GO:0031810 is_a: CCO:F0004819 ! metabotropic histamine receptor binding [Term] id: CCO:F0004824 name: metabotropic nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a metabotropic nucleotide receptor." [GOC:mah, GOC:nln] synonym: "metabotropic nucleotide receptor ligand" NARROW [] synonym: "P2Y receptor binding" EXACT [] xref: GO:0031811 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004825 name: P2Y1 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a P2Y1 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y1 nucleotide receptor ligand" NARROW [] xref: GO:0031812 is_a: CCO:F0004824 ! metabotropic nucleotide receptor binding [Term] id: CCO:F0004826 name: P2Y2 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a P2Y2 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y2 nucleotide receptor ligand" NARROW [] xref: GO:0031813 is_a: CCO:F0004824 ! metabotropic nucleotide receptor binding [Term] id: CCO:F0004827 name: P2Y4 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a P2Y4 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y4 nucleotide receptor ligand" NARROW [] xref: GO:0031814 is_a: CCO:F0004824 ! metabotropic nucleotide receptor binding [Term] id: CCO:F0004828 name: P2Y5 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a P2Y5 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y5 nucleotide receptor ligand" NARROW [] xref: GO:0031815 is_a: CCO:F0004824 ! metabotropic nucleotide receptor binding [Term] id: CCO:F0004829 name: P2Y6 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a P2Y6 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y6 nucleotide receptor ligand" NARROW [] xref: GO:0031816 is_a: CCO:F0004824 ! metabotropic nucleotide receptor binding [Term] id: CCO:F0004830 name: P2Y8 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a P2Y8 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y8 nucleotide receptor ligand" NARROW [] xref: GO:0031817 is_a: CCO:F0004824 ! metabotropic nucleotide receptor binding [Term] id: CCO:F0004831 name: P2Y9 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a P2Y9 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y9 nucleotide receptor ligand" NARROW [] xref: GO:0031818 is_a: CCO:F0004824 ! metabotropic nucleotide receptor binding [Term] id: CCO:F0004832 name: P2Y10 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a P2Y10 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y10 nucleotide receptor ligand" NARROW [] xref: GO:0031819 is_a: CCO:F0004824 ! metabotropic nucleotide receptor binding [Term] id: CCO:F0004833 name: P2Y11 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively with a P2Y11 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y11 nucleotide receptor ligand" NARROW [] xref: GO:0031820 is_a: CCO:F0004824 ! metabotropic nucleotide receptor binding [Term] id: CCO:F0004834 name: metabotropic serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a metabotropic serotonin receptor." [GOC:mah, GOC:nln] synonym: "metabotropic 5-hydroxytryptamine receptor binding" EXACT [] synonym: "metabotropic serotonin receptor ligand" NARROW [] xref: GO:0031821 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004835 name: type 1B serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1B receptor binding" EXACT [] synonym: "type 1B serotonin receptor ligand" NARROW [] xref: GO:0031822 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004836 name: type 1D serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1D serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1D receptor binding" EXACT [] synonym: "type 1D serotonin receptor ligand" NARROW [] xref: GO:0031823 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004837 name: type 1E serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1E serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1E receptor binding" EXACT [] synonym: "type 1E serotonin receptor ligand" NARROW [] xref: GO:0031824 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004838 name: type 1F serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1F serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1F receptor binding" EXACT [] synonym: "type 1F serotonin receptor ligand" NARROW [] xref: GO:0031825 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004839 name: type 2A serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 2A serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2A receptor binding" EXACT [] synonym: "type 2A serotonin receptor ligand" NARROW [] xref: GO:0031826 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004840 name: type 2B serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 2B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2B receptor binding" EXACT [] synonym: "type 2B serotonin receptor ligand" NARROW [] xref: GO:0031827 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004841 name: type 2C serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 2C serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2C receptor binding" EXACT [] synonym: "type 2C serotonin receptor ligand" NARROW [] xref: GO:0031828 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004842 name: type 4 serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 4 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 4 receptor binding" EXACT [] synonym: "type 4 serotonin receptor ligand" NARROW [] xref: GO:0031829 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004843 name: type 5A serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 5A serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 5A receptor binding" EXACT [] synonym: "type 5A serotonin receptor ligand" NARROW [] xref: GO:0031830 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004844 name: type 5B serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 5B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 5B receptor binding" EXACT [] synonym: "type 5B serotonin receptor ligand" NARROW [] xref: GO:0031831 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004845 name: type 6 serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 6 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 6 receptor binding" EXACT [] synonym: "type 6 serotonin receptor ligand" NARROW [] xref: GO:0031832 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004846 name: type 7 serotonin receptor binding namespace: molecular_function def: "Interacting selectively with a type 7 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 7 receptor binding" EXACT [] synonym: "type 7 serotonin receptor ligand" NARROW [] xref: GO:0031833 is_a: CCO:F0004834 ! metabotropic serotonin receptor binding [Term] id: CCO:F0004847 name: neurokinin receptor binding namespace: molecular_function def: "Interacting selectively with a neurokinin receptor." [GOC:mah, GOC:nln] synonym: "neurokinin receptor ligand" NARROW [] xref: GO:0031834 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004848 name: substance P receptor binding namespace: molecular_function def: "Interacting selectively with a substance P receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-1 receptor binding" EXACT [] synonym: "substance P receptor ligand" NARROW [] xref: GO:0031835 is_a: CCO:F0004847 ! neurokinin receptor binding [Term] id: CCO:F0004849 name: neuromedin K receptor binding namespace: molecular_function def: "Interacting selectively with a neuromedin K receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-B receptor binding" EXACT [] synonym: "neuromedin K receptor ligand" NARROW [] xref: GO:0031836 is_a: CCO:F0004847 ! neurokinin receptor binding [Term] id: CCO:F0004850 name: substance K receptor binding namespace: molecular_function def: "Interacting selectively with a substance K receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-A receptor binding" EXACT [] synonym: "substance K receptor ligand" NARROW [] xref: GO:0031837 is_a: CCO:F0004847 ! neurokinin receptor binding [Term] id: CCO:F0004851 name: type 1 neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 neuromedin U receptor." [GOC:mah, GOC:nln] synonym: "type 1 neuromedin U receptor ligand" NARROW [] xref: GO:0031839 is_a: CCO:F0005745 ! neuromedin U receptor binding [Term] id: CCO:F0004852 name: type 2 neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 neuromedin U receptor." [GOC:mah, GOC:nln] synonym: "type 2 neuromedin U receptor ligand" NARROW [] xref: GO:0031840 is_a: CCO:F0005745 ! neuromedin U receptor binding [Term] id: CCO:F0004853 name: neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively with a neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "neuropeptide Y receptor ligand" NARROW [] synonym: "NPY receptor binding" EXACT [] xref: GO:0031841 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004854 name: type 1 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 1 neuropeptide Y receptor ligand" NARROW [] xref: GO:0031842 is_a: CCO:F0004853 ! neuropeptide Y receptor binding [Term] id: CCO:F0004855 name: type 2 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 2 neuropeptide Y receptor ligand" NARROW [] xref: GO:0031843 is_a: CCO:F0004853 ! neuropeptide Y receptor binding [Term] id: CCO:F0004856 name: type 4 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively with a type 4 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "pancreatic polypeptide receptor binding" EXACT [] synonym: "type 4 neuropeptide Y receptor ligand" NARROW [] xref: GO:0031844 is_a: CCO:F0004853 ! neuropeptide Y receptor binding [Term] id: CCO:F0004857 name: type 5 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively with a type 5 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 5 neuropeptide Y receptor ligand" NARROW [] xref: GO:0031845 is_a: CCO:F0004853 ! neuropeptide Y receptor binding [Term] id: CCO:F0004858 name: neurotensin receptor binding namespace: molecular_function def: "Interacting selectively with a neurotensin receptor." [GOC:mah, GOC:nln] synonym: "neurotensin receptor ligand" NARROW [] xref: GO:0031846 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004859 name: type 1 neurotensin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 neurotensin receptor." [GOC:mah, GOC:nln] synonym: "type 1 neurotensin receptor ligand" NARROW [] xref: GO:0031847 is_a: CCO:F0004858 ! neurotensin receptor binding [Term] id: CCO:F0004860 name: olfactory receptor binding namespace: molecular_function def: "Interacting selectively with an olfactory receptor." [GOC:mah, GOC:nln] synonym: "olfactory receptor ligand" NARROW [] xref: GO:0031849 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004861 name: delta-type opioid receptor binding namespace: molecular_function def: "Interacting selectively with a delta-type opioid receptor." [GOC:mah, GOC:nln] synonym: "delta-type opioid receptor ligand" NARROW [] xref: GO:0031850 is_a: CCO:F0004691 ! opioid receptor binding [Term] id: CCO:F0004862 name: kappa-type opioid receptor binding namespace: molecular_function def: "Interacting selectively with a kappa-type opioid receptor." [GOC:mah, GOC:nln] synonym: "kappa-type opioid receptor ligand" NARROW [] xref: GO:0031851 is_a: CCO:F0004691 ! opioid receptor binding [Term] id: CCO:F0004863 name: mu-type opioid receptor binding namespace: molecular_function def: "Interacting selectively with a mu-type opioid receptor." [GOC:mah, GOC:nln] synonym: "mu-type opioid receptor ligand" NARROW [] xref: GO:0031852 is_a: CCO:F0004691 ! opioid receptor binding [Term] id: CCO:F0004864 name: nociceptin receptor binding namespace: molecular_function def: "Interacting selectively with a nociceptin receptor." [GOC:mah, GOC:nln] synonym: "nociceptin receptor ligand" NARROW [] xref: GO:0031853 is_a: CCO:F0004691 ! opioid receptor binding [Term] id: CCO:F0004865 name: orexigenic neuropeptide QRFP receptor binding namespace: molecular_function def: "Interacting selectively with an orexigenic neuropeptide QRFP receptor." [GOC:mah, GOC:nln] synonym: "orexigenic neuropeptide QRFP receptor ligand" NARROW [] xref: GO:0031854 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004866 name: oxytocin receptor binding namespace: molecular_function def: "Interacting selectively with an oxytocin receptor." [GOC:mah, GOC:nln] synonym: "oxytocin receptor ligand" NARROW [] xref: GO:0031855 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004867 name: parathyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively with a parathyroid hormone receptor." [GOC:mah, GOC:nln] synonym: "parathyroid hormone receptor ligand" NARROW [] xref: GO:0031856 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004868 name: type 1 parathyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 parathyroid hormone receptor." [GOC:mah, GOC:nln] synonym: "type 1 parathyroid hormone receptor ligand" NARROW [] xref: GO:0031857 is_a: CCO:F0004867 ! parathyroid hormone receptor binding [Term] id: CCO:F0004869 name: pituitary adenylate cyclase-activating peptide receptor binding namespace: molecular_function def: "Interacting selectively with a pituitary adenylate cyclase-activating peptide receptor." [GOC:mah, GOC:nln] synonym: "PACAP receptor binding" EXACT [] synonym: "pituitary adenylate cyclase-activating peptide receptor ligand" NARROW [] xref: GO:0031858 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004870 name: platelet activating factor receptor binding namespace: molecular_function def: "Interacting selectively with a platelet activating factor receptor." [GOC:mah, GOC:nln] synonym: "platelet activating factor receptor ligand" NARROW [] xref: GO:0031859 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004871 name: prolactin-releasing peptide receptor binding namespace: molecular_function def: "Interacting selectively with a prolactin-releasing peptide receptor." [GOC:mah, GOC:nln] synonym: "prolactin-releasing peptide receptor ligand" NARROW [] xref: GO:0031861 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004872 name: prostanoid receptor binding namespace: molecular_function def: "Interacting selectively with a prostanoid receptor." [GOC:mah, GOC:nln] synonym: "prostanoid receptor ligand" NARROW [] xref: GO:0031862 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004873 name: prostaglandin D2 receptor binding namespace: molecular_function def: "Interacting selectively with a prostaglandin D2 receptor." [GOC:mah, GOC:nln] synonym: "prostaglandin D2 receptor ligand" NARROW [] synonym: "prostanoid DP receptor binding" EXACT [] xref: GO:0031863 is_a: CCO:F0004872 ! prostanoid receptor binding [Term] id: CCO:F0004874 name: EP1 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively with an EP1 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP1 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP1 receptor binding" EXACT [] xref: GO:0031864 is_a: CCO:F0004872 ! prostanoid receptor binding [Term] id: CCO:F0004875 name: EP2 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively with an EP2 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP2 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP2 receptor binding" EXACT [] xref: GO:0031865 is_a: CCO:F0004872 ! prostanoid receptor binding [Term] id: CCO:F0004876 name: EP3 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively with an EP3 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP3 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP3 receptor binding" EXACT [] xref: GO:0031866 is_a: CCO:F0004872 ! prostanoid receptor binding [Term] id: CCO:F0004877 name: EP4 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively with an EP4 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP4 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP4 receptor binding" EXACT [] xref: GO:0031867 is_a: CCO:F0004872 ! prostanoid receptor binding [Term] id: CCO:F0004878 name: prostaglandin F2-alpha receptor binding namespace: molecular_function def: "Interacting selectively with a prostaglandin F2-alpha receptor." [GOC:mah, GOC:nln] synonym: "prostaglandin F2-alpha receptor ligand" NARROW [] synonym: "prostanoid FP receptor binding" EXACT [] xref: GO:0031868 is_a: CCO:F0004872 ! prostanoid receptor binding [Term] id: CCO:F0004879 name: prostacyclin receptor binding namespace: molecular_function def: "Interacting selectively with a prostacyclin receptor." [GOC:mah, GOC:nln] synonym: "prostacyclin receptor ligand" NARROW [] synonym: "prostanoid IP receptor binding" EXACT [] xref: GO:0031869 is_a: CCO:F0004872 ! prostanoid receptor binding [Term] id: CCO:F0004880 name: thromboxane A2 receptor binding namespace: molecular_function def: "Interacting selectively with a thromboxane A2 receptor." [GOC:mah, GOC:nln] synonym: "prostanoid TP receptor binding" EXACT [] synonym: "thromboxane A2 receptor ligand" NARROW [] xref: GO:0031870 is_a: CCO:F0004872 ! prostanoid receptor binding [Term] id: CCO:F0004881 name: proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively with a proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "proteinase activated receptor ligand" NARROW [] xref: GO:0031871 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004882 name: type 1 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "thrombin receptor binding" EXACT [] synonym: "type 1 proteinase activated receptor ligand" NARROW [] xref: GO:0031872 is_a: CCO:F0004881 ! proteinase activated receptor binding [Term] id: CCO:F0004883 name: type 2 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 2 proteinase activated receptor ligand" NARROW [] xref: GO:0031873 is_a: CCO:F0004881 ! proteinase activated receptor binding [Term] id: CCO:F0004884 name: type 3 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively with a type 3 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 3 proteinase activated receptor ligand" NARROW [] xref: GO:0031874 is_a: CCO:F0004881 ! proteinase activated receptor binding [Term] id: CCO:F0004885 name: type 4 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively with a type 4 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 4 proteinase activated receptor ligand" NARROW [] xref: GO:0031875 is_a: CCO:F0004881 ! proteinase activated receptor binding [Term] id: CCO:F0004886 name: secretin receptor binding namespace: molecular_function def: "Interacting selectively with a secretin receptor." [GOC:mah, GOC:nln] synonym: "secretin receptor ligand" NARROW [] xref: GO:0031876 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004887 name: somatostatin receptor binding namespace: molecular_function def: "Interacting selectively with a somatostatin receptor." [GOC:mah, GOC:nln] synonym: "somatostatin receptor ligand" NARROW [] xref: GO:0031877 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004888 name: type 1 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 1 somatostatin receptor ligand" NARROW [] xref: GO:0031878 is_a: CCO:F0004887 ! somatostatin receptor binding [Term] id: CCO:F0004889 name: type 2 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 2 somatostatin receptor ligand" NARROW [] xref: GO:0031879 is_a: CCO:F0004887 ! somatostatin receptor binding [Term] id: CCO:F0004890 name: type 3 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively with a type 3 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 3 somatostatin receptor ligand" NARROW [] xref: GO:0031880 is_a: CCO:F0004887 ! somatostatin receptor binding [Term] id: CCO:F0004891 name: type 4 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively with a type 4 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 4 somatostatin receptor ligand" NARROW [] xref: GO:0031881 is_a: CCO:F0004887 ! somatostatin receptor binding [Term] id: CCO:F0004892 name: type 5 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively with a type 5 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 5 somatostatin receptor ligand" NARROW [] xref: GO:0031882 is_a: CCO:F0004887 ! somatostatin receptor binding [Term] id: CCO:F0004893 name: taste receptor binding namespace: molecular_function def: "Interacting selectively with a taste receptor." [GOC:mah, GOC:nln] synonym: "taste receptor ligand" NARROW [] xref: GO:0031883 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004894 name: type 1 member 1 taste receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 member 1 taste receptor." [GOC:mah, GOC:nln] synonym: "type 1 member 1 taste receptor ligand" NARROW [] xref: GO:0031884 is_a: CCO:F0004893 ! taste receptor binding [Term] id: CCO:F0004895 name: type 1 member 2 taste receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 member 2 taste receptor." [GOC:mah, GOC:nln] synonym: "type 1 member 2 taste receptor ligand" NARROW [] xref: GO:0031885 is_a: CCO:F0004893 ! taste receptor binding [Term] id: CCO:F0004896 name: type 1 member 3 taste receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 member 3 taste receptor." [GOC:mah, GOC:nln] synonym: "sweet taste receptor binding" EXACT [] synonym: "type 1 member 3 taste receptor ligand" NARROW [] xref: GO:0031886 is_a: CCO:F0004893 ! taste receptor binding [Term] id: CCO:F0004897 name: urotensin receptor binding namespace: molecular_function def: "Interacting selectively with a urotensin receptor." [GOC:mah, GOC:nln] synonym: "urotensin receptor ligand" NARROW [] xref: GO:0031889 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004898 name: vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively with a vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "VIP receptor binding" EXACT [] xref: GO:0031890 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004899 name: type 1 vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively with a type 1 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "type 1 vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "type 2 PACAP receptor binding" EXACT [] xref: GO:0031891 is_a: CCO:F0004898 ! vasoactive intestinal polypeptide receptor binding [Term] id: CCO:F0004900 name: type 2 vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively with a type 2 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "type 2 vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "type 3 PACAP receptor binding" EXACT [] xref: GO:0031892 is_a: CCO:F0004898 ! vasoactive intestinal polypeptide receptor binding [Term] id: CCO:F0004901 name: vasopressin receptor binding namespace: molecular_function def: "Interacting selectively with a vasopressin receptor." [GOC:mah, GOC:nln] synonym: "vasopressin receptor ligand" NARROW [] xref: GO:0031893 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0004902 name: V1A vasopressin receptor binding namespace: molecular_function def: "Interacting selectively with a V1A vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V1A vasopressin receptor ligand" NARROW [] xref: GO:0031894 is_a: CCO:F0004901 ! vasopressin receptor binding [Term] id: CCO:F0004903 name: V1B vasopressin receptor binding namespace: molecular_function def: "Interacting selectively with a V1B vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V1B vasopressin receptor ligand" NARROW [] xref: GO:0031895 is_a: CCO:F0004901 ! vasopressin receptor binding [Term] id: CCO:F0004904 name: V2 vasopressin receptor binding namespace: molecular_function def: "Interacting selectively with a V2 vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V2 vasopressin receptor ligand" NARROW [] xref: GO:0031896 is_a: CCO:F0004901 ! vasopressin receptor binding [Term] id: CCO:F0004905 name: vitamin B6 transporter activity namespace: molecular_function def: "Enables the directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of, within or between cells." [GOC:mah] xref: GO:0031924 is_a: CCO:F0008065 ! vitamin transporter activity [Term] id: CCO:F0004906 name: pyridoxal transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pyridoxal across a membrane into, out of, within or between cells. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxal transporter activity" BROAD [] xref: GO:0031925 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity is_a: CCO:F0004905 ! vitamin B6 transporter activity [Term] id: CCO:F0004907 name: pyridoxal phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pyridoxal phosphate into, out of, within or between cells; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] xref: GO:0031926 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity is_a: CCO:F0004905 ! vitamin B6 transporter activity [Term] id: CCO:F0004908 name: pyridoxamine transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pyridoxamine into, out of, within or between cells. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] xref: GO:0031927 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity is_a: CCO:F0004905 ! vitamin B6 transporter activity [Term] id: CCO:F0004909 name: pyridoxine transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pyridoxine across a membrane into, out of, within or between cells. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxine transporter activity" BROAD [] xref: GO:0031928 is_a: CCO:F0004310 ! substrate-specific transmembrane transporter activity is_a: CCO:F0004905 ! vitamin B6 transporter activity [Term] id: CCO:F0004910 name: short-chain-fatty-acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids have chain lengths of less than 8 carbons." [EC:6.2.1.3, GOC:mah] synonym: "short-chain fatty acid activation" RELATED [] synonym: "short-chain fatty acid-CoA ligase activity" EXACT [] xref: GO:0031955 is_a: CCO:F0002996 ! fatty-acid ligase activity [Term] id: CCO:F0004911 name: medium-chain-fatty-acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; medium-chain fatty acids have chain lengths of C8-12." [EC:6.2.1.3, GOC:mah] synonym: "medium-chain fatty acid activation" RELATED [] synonym: "medium-chain fatty acid-CoA ligase activity" EXACT [] xref: GO:0031956 is_a: CCO:F0002996 ! fatty-acid ligase activity [Term] id: CCO:F0004912 name: very-long-chain-fatty-acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18." [EC:6.2.1.3, GOC:mah] synonym: "very-long-chain fatty acid activation" RELATED [] synonym: "very-long-chain fatty acid-CoA ligase activity" EXACT [] xref: GO:0031957 is_a: CCO:F0002996 ! fatty-acid ligase activity [Term] id: CCO:F0004913 name: cortisol receptor binding namespace: molecular_function def: "Interacting selectively with a cortisol receptor." [GOC:mah, PMID:12511169] xref: GO:0031961 is_a: CCO:F0005587 ! glucocorticoid receptor binding [Term] id: CCO:F0004914 name: mineralocorticoid receptor binding namespace: molecular_function def: "Interacting selectively with a mineralocorticoid receptor." [GOC:mah, PMID:12511169] xref: GO:0031962 is_a: CCO:F0005586 ! steroid hormone receptor binding [Term] id: CCO:F0004915 name: cortisol receptor activity namespace: molecular_function def: "Combining with cortisol to initiate a change in cell activity." [GOC:mah, PMID:12511169] xref: GO:0031963 is_a: CCO:F0001236 ! glucocorticoid receptor activity [Term] id: CCO:F0004916 name: beta-alanyl-histamine hydrolase activity namespace: molecular_function def: "Catalysis of the conversion of beta-alanyl-histamine to histamine." [GOC:rc, PMID:16299587] synonym: "carcinine hydrolase activity" EXACT [] xref: GO:0031964 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0004917 name: energy transducer activity namespace: molecular_function def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators] subset: goslim_pir synonym: "light harvesting activity" RELATED [] synonym: "photon capture" RELATED [] xref: GO:0031992 is_a: CCO:F0008240 ! molecular transducer activity [Term] id: CCO:F0004918 name: light transducer activity namespace: molecular_function def: "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell." [GOC:mah, GOC:mlg] xref: GO:0031993 is_a: CCO:F0004917 ! energy transducer activity [Term] id: CCO:F0004919 name: insulin-like growth factor I binding namespace: molecular_function def: "Interacting selectively with insulin-like growth factor I." [GOC:mah] synonym: "IGF-I binding" EXACT [] xref: GO:0031994 is_a: CCO:F0001651 ! insulin-like growth factor binding [Term] id: CCO:F0004920 name: insulin-like growth factor II binding namespace: molecular_function def: "Interacting selectively with insulin-like growth factor II." [GOC:mah] synonym: "IGF-II binding" EXACT [] xref: GO:0031995 is_a: CCO:F0001651 ! insulin-like growth factor binding [Term] id: CCO:F0004921 name: thioesterase binding namespace: molecular_function def: "Interacting selectively with any thioesterase enzyme." [GOC:dl] synonym: "thiolesterase binding" EXACT [] xref: GO:0031996 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0004922 name: N-terminal myristoylation domain binding namespace: molecular_function def: "Interacting selectively with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." [GOC:dl, GOC:jsg, PMID:15632291] xref: GO:0031997 is_a: CCO:F0006791 ! protein N-terminus binding [Term] id: CCO:F0004923 name: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer an alpha-D-glucosyl residue in a 1,4-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a 1,4-alpha-D-glucan." [EC:2.4.1.24] synonym: "1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity" EXACT [] synonym: "D-glucosyltransferase" BROAD [] synonym: "oligoglucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.24] synonym: "T-enzyme" NARROW [] xref: EC:2.4.1.24 xref: GO:0032001 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0004924 name: interleukin-28 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-28 receptor." [GOC:rh2] synonym: "IL-28" NARROW [] synonym: "interleukin-28 receptor ligand" NARROW [] xref: GO:0032003 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0004925 name: 2-methylbutanal reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+." [GOC:mah, PMID:12210903] synonym: "2-methylbutyraldehyde reductase activity" EXACT [] xref: GO:0032018 is_a: CCO:F0000510 ! aldehyde reductase activity [Term] id: CCO:F0004926 name: myosin light chain binding namespace: molecular_function def: "Interacting selectively with a light chain of a myosin complex." [GOC:mah] xref: GO:0032027 is_a: CCO:F0003516 ! myosin binding [Term] id: CCO:F0004927 name: myosin head/neck binding namespace: molecular_function def: "Interacting selectively with the head/neck region of a myosin heavy chain." [GOC:mah] xref: GO:0032028 is_a: CCO:F0004935 ! myosin heavy chain binding [Term] id: CCO:F0004928 name: myosin tail binding namespace: molecular_function def: "Interacting selectively with the tail region of a myosin heavy chain." [GOC:mah] xref: GO:0032029 is_a: CCO:F0004935 ! myosin heavy chain binding [Term] id: CCO:F0004929 name: myosin I light chain binding namespace: molecular_function def: "Interacting selectively with a light chain of a myosin I complex." [GOC:mah] xref: GO:0032030 is_a: CCO:F0003517 ! myosin I binding is_a: CCO:F0004926 ! myosin light chain binding [Term] id: CCO:F0004930 name: myosin I head/neck binding namespace: molecular_function def: "Interacting selectively with the head/neck region of a myosin I heavy chain." [GOC:mah] xref: GO:0032031 is_a: CCO:F0004927 ! myosin head/neck binding is_a: CCO:F0004936 ! myosin I heavy chain binding [Term] id: CCO:F0004931 name: myosin I tail binding namespace: molecular_function def: "Interacting selectively with the tail region of a myosin I heavy chain." [GOC:mah] xref: GO:0032032 is_a: CCO:F0004928 ! myosin tail binding is_a: CCO:F0004936 ! myosin I heavy chain binding [Term] id: CCO:F0004932 name: myosin II light chain binding namespace: molecular_function def: "Interacting selectively with a light chain of a myosin II complex." [GOC:mah] xref: GO:0032033 is_a: CCO:F0004926 ! myosin light chain binding is_a: CCO:F0006091 ! myosin II binding [Term] id: CCO:F0004933 name: myosin II head/neck binding namespace: molecular_function def: "Interacting selectively with the head/neck region of a myosin II heavy chain." [GOC:mah] xref: GO:0032034 is_a: CCO:F0004927 ! myosin head/neck binding is_a: CCO:F0004937 ! myosin II heavy chain binding [Term] id: CCO:F0004934 name: myosin II tail binding namespace: molecular_function def: "Interacting selectively with the tail region of a myosin II heavy chain." [GOC:mah] xref: GO:0032035 is_a: CCO:F0004928 ! myosin tail binding is_a: CCO:F0004937 ! myosin II heavy chain binding [Term] id: CCO:F0004935 name: myosin heavy chain binding namespace: molecular_function def: "Interacting selectively with a heavy chain of a myosin complex." [GOC:mah] xref: GO:0032036 is_a: CCO:F0003516 ! myosin binding [Term] id: CCO:F0004936 name: myosin I heavy chain binding namespace: molecular_function def: "Interacting selectively with a heavy chain of a myosin I complex." [GOC:mah] xref: GO:0032037 is_a: CCO:F0003517 ! myosin I binding is_a: CCO:F0004935 ! myosin heavy chain binding [Term] id: CCO:F0004937 name: myosin II heavy chain binding namespace: molecular_function def: "Interacting selectively with a heavy chain of a myosin II complex." [GOC:mah] xref: GO:0032038 is_a: CCO:F0004935 ! myosin heavy chain binding is_a: CCO:F0006091 ! myosin II binding [Term] id: CCO:F0004938 name: NAD-dependent histone deacetylase activity (H3-K14 specific) namespace: molecular_function def: "Catalysis of the NAD-dependent removal of an acetyl group from lysine at position 14 of the histone H3 protein." [GOC:mah] xref: GO:0032041 is_a: CCO:F0003591 ! NAD-dependent histone deacetylase activity is_a: CCO:F0004630 ! histone deacetylase activity (H3-K14 specific) [Term] id: CCO:F0004939 name: clathrin heavy chain binding namespace: molecular_function def: "Interacting selectively with a clathrin heavy chain." [GOC:mah] xref: GO:0032050 is_a: CCO:F0004372 ! clathrin binding [Term] id: CCO:F0004940 name: clathrin light chain binding namespace: molecular_function def: "Interacting selectively with a clathrin light chain." [GOC:mah] xref: GO:0032051 is_a: CCO:F0004372 ! clathrin binding [Term] id: CCO:F0004941 name: bile acid binding namespace: molecular_function def: "Interacting selectively with bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:rph] xref: GO:0032052 is_a: CCO:F0004660 ! carboxylic acid binding [Term] id: CCO:F0004942 name: Type IV site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)." [PMID:12654995] synonym: "Type IV restriction enzyme activity" EXACT [] xref: GO:0032067 is_a: CCO:F0003014 ! restriction endodeoxyribonuclease activity [Term] id: CCO:F0004943 name: NACHT domain binding namespace: molecular_function def: "Interacting selectively with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, an Mg(2+)-binding site and five more specific motifs." [GOC:rl] xref: GO:0032089 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004944 name: Pyrin domain binding namespace: molecular_function def: "Interacting selectively with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl] synonym: "DAPIN domain binding" EXACT [] synonym: "PAAD domain binding" EXACT [] xref: GO:0032090 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004945 name: SAM domain binding namespace: molecular_function def: "Interacting selectively with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230] synonym: "Sterile Alpha Motif domain binding" EXACT [] xref: GO:0032093 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004946 name: sorbose reductase activity namespace: molecular_function def: "L-sorbose + NADPH + H+ = D-glucitol + NADP+. The reaction may occur, to a minor extent, in the reverse direction." [EC:1.1.11.289, GOC:mcc] synonym: "D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.289] synonym: "Sou1p" RELATED [EC:1.1.1.289] xref: EC:1.1.1.289 xref: GO:0032115 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004947 name: histone deacetylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [GOC:mah] xref: GO:0032129 is_a: CCO:F0000816 ! histone deacetylase activity [Term] id: CCO:F0004948 name: alkylated DNA binding namespace: molecular_function def: "Interacting selectively with alkylated residues in DNA." [GOC:mah] xref: GO:0032131 is_a: CCO:F0000279 ! damaged DNA binding [Term] id: CCO:F0004949 name: O6-alkylguanine-DNA binding namespace: molecular_function def: "Interacting selectively with O6-alkylguanine adducts in DNA." [GOC:mah, PMID:16679453] xref: GO:0032132 is_a: CCO:F0004948 ! alkylated DNA binding [Term] id: CCO:F0004950 name: mispaired DNA binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing pyrimidine/purine mispairs." [GOC:vk] synonym: "mispair binding" EXACT [] xref: GO:0032134 is_a: CCO:F0004616 ! mismatched DNA binding [Term] id: CCO:F0004951 name: DNA insertion or deletion binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing insertions or deletions." [GOC:vk] synonym: "DNA insertion binding" NARROW [] synonym: "insertion binding" EXACT [] xref: GO:0032135 is_a: CCO:F0004616 ! mismatched DNA binding [Term] id: CCO:F0004952 name: adenine/cytosine mispair binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing an A/C mispair." [GOC:vk] synonym: "A/C mispair binding" EXACT [] xref: GO:0032136 is_a: CCO:F0004950 ! mispaired DNA binding [Term] id: CCO:F0004953 name: guanine/thymine mispair binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing an G/T mispair." [GOC:vk] synonym: "G/T mispair binding" EXACT [] xref: GO:0032137 is_a: CCO:F0004950 ! mispaired DNA binding [Term] id: CCO:F0004954 name: single base insertion or deletion binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing a single base insertion or deletion." [GOC:vk] synonym: "single base insertion binding" NARROW [] xref: GO:0032138 is_a: CCO:F0004951 ! DNA insertion or deletion binding [Term] id: CCO:F0004955 name: dinucleotide insertion or deletion binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing a dinucleotide insertion or deletion." [GOC:vk] synonym: "dinucleotide insertion binding" NARROW [] xref: GO:0032139 is_a: CCO:F0004951 ! DNA insertion or deletion binding [Term] id: CCO:F0004956 name: single adenine insertion binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing a single adenine insertion or a deletion that results in an unpaired adenine." [GOC:mah, GOC:vk] xref: GO:0032140 is_a: CCO:F0004954 ! single base insertion or deletion binding [Term] id: CCO:F0004957 name: single cytosine insertion binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing a single cytosine insertion or a deletion that results in an unpaired cytosine." [GOC:mah, GOC:vk] xref: GO:0032141 is_a: CCO:F0004954 ! single base insertion or deletion binding [Term] id: CCO:F0004958 name: single guanine insertion binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine." [GOC:mah, GOC:vk] xref: GO:0032142 is_a: CCO:F0004954 ! single base insertion or deletion binding [Term] id: CCO:F0004959 name: single thymine insertion binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine." [GOC:mah, GOC:vk] xref: GO:0032143 is_a: CCO:F0004954 ! single base insertion or deletion binding [Term] id: CCO:F0004960 name: succinate-semialdehyde dehydrogenase binding namespace: molecular_function def: "Interacting selectively with succinate-semialdehyde dehydrogenase." [GOC:mah] synonym: "succinic semialdehyde dehydrogenase binding" EXACT [] xref: GO:0032145 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0004961 name: thiosulfate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)." [GOC:mlg] xref: GO:0032146 is_a: CCO:F0002595 ! thiosulfate transmembrane transporter activity is_a: CCO:F0005824 ! anion transmembrane-transporting ATPase activity [Term] id: CCO:F0004962 name: dinucleotide repeat insertion binding namespace: molecular_function def: "Interacting selectively with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats." [GOC:mah, GOC:vk] xref: GO:0032181 is_a: CCO:F0004955 ! dinucleotide insertion or deletion binding [Term] id: CCO:F0004963 name: small conjugating protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] xref: GO:0032182 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004964 name: SUMO binding namespace: molecular_function def: "Interacting selectively with the small ubiquitin-like protein SUMO." [GOC:mah] synonym: "Smt3 binding" RELATED [] synonym: "Smt3 monomer binding" NARROW [] xref: GO:0032183 is_a: CCO:F0004963 ! small conjugating protein binding [Term] id: CCO:F0004965 name: SUMO polymer binding namespace: molecular_function def: "Interacting selectively with a polymer of the small ubiquitin-like protein SUMO." [GOC:mah] synonym: "Smt3 polymer binding" EXACT [] xref: GO:0032184 is_a: CCO:F0004964 ! SUMO binding [Term] id: CCO:F0004966 name: acrosin binding namespace: molecular_function def: "Interacting selectively with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities." [GOC:mah, PMID:12398221] xref: GO:0032190 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0004967 name: acrosin heavy chain binding namespace: molecular_function def: "Interacting selectively with the larger of the two covalently linked polypeptide chains of acrosin." [GOC:mah, PMID:12398221] xref: GO:0032191 is_a: CCO:F0004966 ! acrosin binding [Term] id: CCO:F0004968 name: acrosin light chain binding namespace: molecular_function def: "Interacting selectively with the smaller of the two covalently linked polypeptide chains of acrosin." [GOC:mah, PMID:12398221] xref: GO:0032192 is_a: CCO:F0004966 ! acrosin binding [Term] id: CCO:F0004969 name: glucosaminyl-phosphotidylinositol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucosaminyl-phosphotidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phosphotidylinositol + CoA." [Reactome:REACT_1049.1] synonym: "GPI-inositol acyltransferase" RELATED [] xref: EC:2.3.1.- xref: GO:0032216 is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0004970 name: riboflavin transporter activity namespace: molecular_function def: "Facilitates the directed movement of riboflavin into, out of, within or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] xref: GO:0032217 is_a: CCO:F0008065 ! vitamin transporter activity [Term] id: CCO:F0004971 name: phosphatidylinositol 3-phosphate binding namespace: molecular_function def: "Interacting selectively with phosphatidylinositol 3-phosphate, a phosphorylated derivative of phosphatidylinositol." [PMID:11557775] synonym: "PtdIns-3-P binding" EXACT [] xref: GO:0032266 is_a: CCO:F0005562 ! phosphoinositide binding [Term] id: CCO:F0004972 name: tRNA(Ile)-lysidine synthase namespace: molecular_function def: "Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine." [PMID:14527414] synonym: "tRNA(Ile)-2-lysyl-cytidine synthase activity" EXACT [] synonym: "tRNA(Ile)-lysidine synthetase activity" EXACT [] xref: EC:6.3.4.- xref: GO:0032267 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0004973 name: double-stranded RNA-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules." [GOC:mah] synonym: "double-stranded RNA-specific RNase activity" EXACT [] synonym: "dsRNA-specific ribonuclease activity" EXACT [] synonym: "dsRNA-specific RNase activity" EXACT [] xref: GO:0032296 is_a: CCO:F0000934 ! ribonuclease activity [Term] id: CCO:F0004974 name: oxidized DNA binding namespace: molecular_function def: "Interacting selectively with oxidized residues in DNA." [GOC:vk] synonym: "oxidised DNA binding" EXACT [] xref: GO:0032356 is_a: CCO:F0000279 ! damaged DNA binding [Term] id: CCO:F0004975 name: oxidized purine DNA binding namespace: molecular_function def: "Interacting selectively with oxidized purine residues in DNA." [GOC:vk] synonym: "oxidised purine DNA binding" EXACT [] xref: GO:0032357 is_a: CCO:F0004974 ! oxidized DNA binding [Term] id: CCO:F0004976 name: oxidized pyrimidine DNA binding namespace: molecular_function def: "Interacting selectively with oxidized pyrimidine residues in DNA." [GOC:vk] synonym: "oxidised pyrimidine DNA binding" EXACT [] xref: GO:0032358 is_a: CCO:F0004974 ! oxidized DNA binding [Term] id: CCO:F0004977 name: MHC class I receptor activity namespace: molecular_function def: "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] xref: GO:0032393 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0004978 name: MHC class Ib receptor activity namespace: molecular_function def: "Combining with an MHC class Ib protein complex to initiate a change in cellular activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] xref: GO:0032394 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0004979 name: MHC class II receptor activity namespace: molecular_function def: "Combining with an MHC class II protein complex to initiate a change in cellular activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] xref: GO:0032395 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0004980 name: inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134] xref: GO:0032396 is_a: CCO:F0004977 ! MHC class I receptor activity [Term] id: CCO:F0004981 name: activating MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte." [GOC:add, PMID:11858820, PMID:9597134] xref: GO:0032397 is_a: CCO:F0004977 ! MHC class I receptor activity [Term] id: CCO:F0004982 name: HECT domain binding namespace: molecular_function def: "Interacting selectively with a HECT, 'Homologous to the E6-AP Carboxyl Terminus', domain of a protein." [GOC:mah, Pfam:PF00632] xref: GO:0032399 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004983 name: protein complex binding namespace: molecular_function def: "Interacting selectively with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah] xref: GO:0032403 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0004984 name: mismatch repair complex binding namespace: molecular_function def: "Interacting selectively with a mismatch repair complex." [GOC:vk] xref: GO:0032404 is_a: CCO:F0004983 ! protein complex binding [Term] id: CCO:F0004985 name: MutLalpha complex binding namespace: molecular_function def: "Interacting selectively with the mismatch repair complex MutLalpha." [GOC:vk] xref: GO:0032405 is_a: CCO:F0004984 ! mismatch repair complex binding [Term] id: CCO:F0004986 name: MutLbeta complex binding namespace: molecular_function def: "Interacting selectively with the mismatch repair complex MutLbeta." [GOC:vk] xref: GO:0032406 is_a: CCO:F0004984 ! mismatch repair complex binding [Term] id: CCO:F0004987 name: MutSalpha complex binding namespace: molecular_function def: "Interacting selectively with the mismatch repair complex MutSalpha." [GOC:vk] xref: GO:0032407 is_a: CCO:F0004984 ! mismatch repair complex binding [Term] id: CCO:F0004988 name: MutSbeta complex binding namespace: molecular_function def: "Interacting selectively with the mismatch repair complex MutSbeta." [GOC:vk] xref: GO:0032408 is_a: CCO:F0004984 ! mismatch repair complex binding [Term] id: CCO:F0004989 name: purine-rich negative regulatory element binding namespace: molecular_function def: "Interacting selectively with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411] synonym: "PNR element binding" BROAD [] xref: GO:0032422 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0004990 name: GBD domain binding namespace: molecular_function def: "Interacting selectively with the GBD (GTPase protein binding domain) domain of small GTPases." [GOC:pg] synonym: "CRIB motif binding" EXACT [] xref: GO:0032427 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0004991 name: beta-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides." [EC:3.2.1.53] synonym: "beta-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53] synonym: "beta-D-N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53] synonym: "beta-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.53] synonym: "N-acetyl-beta-D-galactosaminidase activity" EXACT [EC:3.2.1.53] synonym: "N-acetyl-beta-galactosaminidase activity" EXACT [EC:3.2.1.53] synonym: "N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53] xref: EC:3.2.1.53 xref: GO:0032428 is_a: CCO:F0000947 ! beta-N-acetylhexosaminidase activity [Term] id: CCO:F0004992 name: 2-alkenal reductase activity namespace: molecular_function def: "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] synonym: "n-alkanal:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.3.1.74] synonym: "NAD(P)H-dependent alkenal/one oxidoreductase activity" EXACT [EC:1.3.1.74] synonym: "NADPH:2-alkenal alpha,beta-hydrogenase activity" EXACT [] xref: EC:1.3.1.74 xref: GO:0032440 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004993 name: pheophorbide a oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite (RCC) + oxidized ferredoxin + H2O." [PMID:14657372, PMID:16448336] xref: EC:1.8.-.- xref: GO:0032441 is_a: CCO:F0003311 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: CCO:F0004994 name: phenylcoumaran benzylic ether reductase activity namespace: molecular_function def: "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction dehydrodiconiferyl alcohol + NADPH = isodihydrodehydrodiconiferyl alcohol + NADP." [PMID:11030549, PMID:13129921] synonym: "PCBER activity" EXACT [] xref: EC:1.1.1.- xref: GO:0032442 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0004995 name: DNA hairpin binding namespace: molecular_function def: "Interacting selectively with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0032448 is_a: CCO:F0000040 ! DNA secondary structure binding [Term] id: CCO:F0004996 name: maltase activity namespace: molecular_function def: "Catalysis of the hydrolysis of maltose by an alpha-D-glucosidase-type action." [GOC:pd] xref: GO:0032450 is_a: CCO:F0000943 ! alpha-glucosidase activity [Term] id: CCO:F0004997 name: demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah] subset: goslim_pir xref: GO:0032451 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0004998 name: histone demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from a histone." [GOC:mah] xref: GO:0032452 is_a: CCO:F0004997 ! demethylase activity [Term] id: CCO:F0004999 name: histone demethylase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein." [GOC:mah] xref: GO:0032453 is_a: CCO:F0004998 ! histone demethylase activity [Term] id: CCO:F0005000 name: histone demethylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from lysine at position 9 of the histone H3 protein." [GOC:mah] xref: GO:0032454 is_a: CCO:F0004998 ! histone demethylase activity [Term] id: CCO:F0005001 name: muramyl dipeptide binding namespace: molecular_function def: "Interacting selectively, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl] xref: GO:0032500 is_a: CCO:F0005721 ! peptidoglycan binding [Term] id: CCO:F0005002 name: amino acid-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(in) = ADP + phosphate + amino acid(out)." [GOC:mah] xref: GO:0032518 is_a: CCO:F0002843 ! amino acid-transporting ATPase activity [Term] id: CCO:F0005003 name: cysteine-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(in) = ADP + phosphate + cysteine(out)." [GOC:mah] synonym: "cysteine exporter" RELATED [] xref: GO:0032519 is_a: CCO:F0005002 ! amino acid-exporting ATPase activity is_a: CCO:F0005091 ! cysteine-transporting ATPase activity [Term] id: CCO:F0005004 name: amino acid-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out) = ADP + phosphate + amino acid(in)." [GOC:mah] xref: GO:0032520 is_a: CCO:F0002843 ! amino acid-transporting ATPase activity [Term] id: CCO:F0005005 name: D-methionine-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(in) = ADP + phosphate + D-methionine(out)." [GOC:mah] synonym: "D-methionine exporter" RELATED [] xref: GO:0032521 is_a: CCO:F0005002 ! amino acid-exporting ATPase activity is_a: CCO:F0005092 ! D-methionine-transporting ATPase activity [Term] id: CCO:F0005006 name: D-methionine-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out) = ADP + phosphate + D-methionine(in)." [GOC:mah] synonym: "D-methionine importer" RELATED [] xref: GO:0032522 is_a: CCO:F0005004 ! amino acid-importing ATPase activity is_a: CCO:F0005092 ! D-methionine-transporting ATPase activity [Term] id: CCO:F0005007 name: silicon efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of silicon from the inside of the cell to the outside of the cell across a membrane." [GOC:mah, PMID:17625566] synonym: "silicon efflux transporter activity" EXACT [] xref: GO:0032523 is_a: CCO:F0001577 ! sugar:hydrogen symporter activity is_a: CCO:F0002942 ! efflux transmembrane transporter activity is_a: CCO:F0005736 ! arabinose transmembrane transporter activity [Term] id: CCO:F0005008 name: sulfiredoxin activity namespace: molecular_function def: "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH <=> peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2] synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity" EXACT [] synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]" RELATED [EC:1.8.98.2] synonym: "Srx1" RELATED [EC:1.8.98.2] synonym: "sulphiredoxin activity" EXACT [] xref: EC:1.8.98.2 xref: GO:0032542 xref: MetaCyc:1.8.98.2-RXN is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0005009 name: deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively with a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose." [GOC:mah] subset: gosubset_prok xref: GO:0032546 is_a: CCO:F0000246 ! nucleoside binding [Term] id: CCO:F0005010 name: purine deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively with a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose." [GOC:mah] subset: gosubset_prok xref: GO:0032547 is_a: CCO:F0000247 ! purine nucleoside binding is_a: CCO:F0005009 ! deoxyribonucleoside binding [Term] id: CCO:F0005011 name: pyrimidine deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively with a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose." [GOC:mah] subset: gosubset_prok xref: GO:0032548 is_a: CCO:F0000248 ! pyrimidine nucleoside binding is_a: CCO:F0005009 ! deoxyribonucleoside binding [Term] id: CCO:F0005012 name: ribonucleoside binding namespace: molecular_function def: "Interacting selectively with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah] subset: gosubset_prok xref: GO:0032549 is_a: CCO:F0000246 ! nucleoside binding [Term] id: CCO:F0005013 name: purine ribonucleoside binding namespace: molecular_function def: "Interacting selectively with a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah] subset: gosubset_prok xref: GO:0032550 is_a: CCO:F0000247 ! purine nucleoside binding is_a: CCO:F0005012 ! ribonucleoside binding [Term] id: CCO:F0005014 name: pyrimidine ribonucleoside binding namespace: molecular_function def: "Interacting selectively with a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose." [GOC:mah] subset: gosubset_prok xref: GO:0032551 is_a: CCO:F0000248 ! pyrimidine nucleoside binding is_a: CCO:F0005012 ! ribonucleoside binding [Term] id: CCO:F0005015 name: deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively with a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032552 is_a: CCO:F0000031 ! nucleotide binding [Term] id: CCO:F0005016 name: ribonucleotide binding namespace: molecular_function def: "Interacting selectively with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032553 is_a: CCO:F0000031 ! nucleotide binding [Term] id: CCO:F0005017 name: purine deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively with a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032554 is_a: CCO:F0003548 ! purine nucleotide binding is_a: CCO:F0005015 ! deoxyribonucleotide binding [Term] id: CCO:F0005018 name: purine ribonucleotide binding namespace: molecular_function def: "Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032555 is_a: CCO:F0003548 ! purine nucleotide binding is_a: CCO:F0005016 ! ribonucleotide binding [Term] id: CCO:F0005019 name: pyrimidine deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively with a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032556 is_a: CCO:F0004050 ! pyrimidine nucleotide binding is_a: CCO:F0005015 ! deoxyribonucleotide binding [Term] id: CCO:F0005020 name: pyrimidine ribonucleotide binding namespace: molecular_function def: "Interacting selectively with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032557 is_a: CCO:F0004050 ! pyrimidine nucleotide binding is_a: CCO:F0005016 ! ribonucleotide binding [Term] id: CCO:F0005021 name: adenyl deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively with an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032558 is_a: CCO:F0004466 ! adenyl nucleotide binding is_a: CCO:F0005017 ! purine deoxyribonucleotide binding [Term] id: CCO:F0005022 name: adenyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032559 is_a: CCO:F0004466 ! adenyl nucleotide binding is_a: CCO:F0005018 ! purine ribonucleotide binding [Term] id: CCO:F0005023 name: guanyl deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively with a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032560 is_a: CCO:F0004044 ! guanyl nucleotide binding is_a: CCO:F0005017 ! purine deoxyribonucleotide binding [Term] id: CCO:F0005024 name: guanyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok xref: GO:0032561 is_a: CCO:F0004044 ! guanyl nucleotide binding is_a: CCO:F0005018 ! purine ribonucleotide binding [Term] id: CCO:F0005025 name: dAMP binding namespace: molecular_function def: "Interacting selectively with dAMP, deoxyadenosine monophosphate." [GOC:mah] xref: GO:0032562 is_a: CCO:F0005021 ! adenyl deoxyribonucleotide binding [Term] id: CCO:F0005026 name: dADP binding namespace: molecular_function def: "Interacting selectively with dADP, deoxyadenosine diphosphate." [GOC:mah] xref: GO:0032563 is_a: CCO:F0005021 ! adenyl deoxyribonucleotide binding [Term] id: CCO:F0005027 name: dATP binding namespace: molecular_function def: "Interacting selectively with dATP, deoxyadenosine triphosphate." [GOC:mah] xref: GO:0032564 is_a: CCO:F0005021 ! adenyl deoxyribonucleotide binding [Term] id: CCO:F0005028 name: dGMP binding namespace: molecular_function def: "Interacting selectively with dGMP, deoxyguanosine monophosphate." [GOC:mah] xref: GO:0032565 is_a: CCO:F0005023 ! guanyl deoxyribonucleotide binding [Term] id: CCO:F0005029 name: dGDP binding namespace: molecular_function def: "Interacting selectively with dGDP, deoxyguanosine diphosphate." [GOC:mah] xref: GO:0032566 is_a: CCO:F0005023 ! guanyl deoxyribonucleotide binding [Term] id: CCO:F0005030 name: dGTP binding namespace: molecular_function def: "Interacting selectively with dGTP, deoxyguanosine triphosphate." [GOC:mah] xref: GO:0032567 is_a: CCO:F0005023 ! guanyl deoxyribonucleotide binding [Term] id: CCO:F0005031 name: 5'-3' RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp] synonym: "5' to 3' RNA helicase activity" EXACT [] xref: GO:0032574 is_a: CCO:F0000309 ! RNA helicase activity [Term] id: CCO:F0005032 name: ATP-dependent 5'-3' RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp] synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT [] xref: GO:0032575 is_a: CCO:F0000488 ! ATP-dependent RNA helicase activity is_a: CCO:F0005031 ! 5'-3' RNA helicase activity [Term] id: CCO:F0005033 name: O-linoleoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule." [GOC:cb] xref: GO:0032576 is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0005034 name: phosphatidylcholine:cardiolipin O-linoleoyltransferase namespace: molecular_function def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah] synonym: "phosphatidylcholine:cardiolipin linoleoyltransferase" EXACT [] xref: GO:0032577 is_a: CCO:F0005033 ! O-linoleoyltransferase activity [Term] id: CCO:F0005035 name: copper-dependent protein binding namespace: molecular_function def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper." [GOC:ecd, PMID:16884690] xref: GO:0032767 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005036 name: cobalt-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] synonym: "cobalt ABC transporter" RELATED [] synonym: "cobalt porter activity" RELATED [] synonym: "cobalt transporting ATPase activity" EXACT [] xref: GO:0015632 xref: GO:0032778 is_a: CCO:F0002567 ! cobalt ion transmembrane transporter activity is_a: CCO:F0004186 ! cation-transporting ATPase activity [Term] id: CCO:F0005037 name: lead ion binding namespace: molecular_function def: "Interacting selectively with lead (Pb) ions." [GOC:mah] subset: goslim_generic subset: gosubset_prok xref: GO:0032791 is_a: CCO:F0005808 ! cation binding is_a: CCO:F0006257 ! metal ion binding [Term] id: CCO:F0005038 name: GTPase activating protein binding namespace: molecular_function def: "Interacting selectively with a GTPase activating protein." [GOC:nln] synonym: "GAP binding" EXACT [] xref: GO:0032794 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005039 name: heterotrimeric G-protein binding namespace: molecular_function def: "Interacting selectively with a eterotrimeric G-protein." [GOC:nln] xref: GO:0032795 is_a: CCO:F0004983 ! protein complex binding [Term] id: CCO:F0005040 name: sterol response element binding namespace: molecular_function def: "Interacting selectively with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399] synonym: "SRE binding" EXACT [] xref: GO:0032810 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0005041 name: tumor necrosis factor receptor superfamily binding namespace: molecular_function def: "Interacting selectively with any member of the tumor necrosis factor receptor superfamily." [GOC:add] synonym: "TNF receptor superfamily binding" EXACT [] xref: GO:0032813 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0005042 name: intramolecular proline-rich ligand binding namespace: molecular_function def: "Interacting selectively with a proline-rich region within the same polypeptide." [GOC:pf] xref: GO:0032840 is_a: CCO:F0005879 ! protein self-association [Term] id: CCO:F0005043 name: calcitonin binding namespace: molecular_function def: "Interacting selectively with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd] xref: GO:0032841 is_a: CCO:F0003529 ! peptide hormone binding [Term] id: CCO:F0005044 name: hydroperoxide reductase namespace: molecular_function def: "Catalysis of the reaction:2RSH + ROOH = RSSR + ROH + H2O, i.e. the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol plus water." [GOC:mlg, PMID:12540833] xref: GO:0032843 is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0005045 name: xylose reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+." [PMID:12724380, PMID:15184173] xref: GO:0032866 is_a: CCO:F0000510 ! aldehyde reductase activity [Term] id: CCO:F0005046 name: arabinose reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+." [PMID:12724380, PMID:15184173] xref: GO:0032867 is_a: CCO:F0000510 ! aldehyde reductase activity [Term] id: CCO:F0005047 name: palmitoyl-CoA 9-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kva] synonym: "palmitoyl-CoA delta9-desaturase acitivity" EXACT [] xref: GO:0032896 is_a: CCO:F0003074 ! CoA desaturase activity [Term] id: CCO:F0005048 name: histone lysine N-acetyltransferase activity (H3-K56 specific) namespace: molecular_function def: "Catalysis of the addition of an acetyl group onto lysine at position 56 of the histone H3 protein." [GOC:mah] xref: GO:0032931 is_a: CCO:F0000815 ! H3/H4 histone acetyltransferase activity [Term] id: CCO:F0005049 name: sterol binding namespace: molecular_function def: "Interacting selectively with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [ChEBI:15889, GOC:mah] subset: gosubset_prok xref: GO:0032934 is_a: CCO:F0001634 ! steroid binding [Term] id: CCO:F0005050 name: sterol sensor activity namespace: molecular_function def: "Interacting selectively with and responding, e.g. by conformational change, to changes in the cellular level of, a sterol." [GOC:mah] synonym: "sterol-sensing domain" NARROW [] xref: GO:0032935 is_a: CCO:F0005049 ! sterol binding [Term] id: CCO:F0005051 name: inositol tetrakisphosphate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP." [GOC:hf] synonym: "1D-myo-inositol-tetrakisphosphate 2-kinase activity" EXACT [] synonym: "inositol 1,3,4,6-tetrakisphosphate 2-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 2-kinase activity" EXACT [] xref: EC:2.7.1.- xref: GO:0032942 is_a: CCO:F0008190 ! inositol tetrakisphosphate kinase activity [Term] id: CCO:F0005052 name: protein complex scaffold namespace: molecular_function def: "Functions to provide a physical suport for the assembly of a multiprotein complex." [GOC:mah] xref: GO:0032947 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005053 name: membrane insertase activity namespace: molecular_function def: "Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family." [PMID:14739936] subset: gosubset_prok xref: GO:0032977 is_a: CCO:F0001997 ! protein transporter activity [Term] id: CCO:F0005054 name: 5-hydroxyvalerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH." [GOC:mlg, PMID:12406764] xref: GO:0033019 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005055 name: bitter taste receptor activity namespace: molecular_function def: "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah] xref: GO:0033038 is_a: CCO:F0001979 ! taste receptor activity [Term] id: CCO:F0005056 name: salty taste receptor activity namespace: molecular_function def: "Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste." [GOC:mah] xref: GO:0033039 is_a: CCO:F0001979 ! taste receptor activity [Term] id: CCO:F0005057 name: sour taste receptor activity namespace: molecular_function def: "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste." [GOC:mah] xref: GO:0033040 is_a: CCO:F0001979 ! taste receptor activity [Term] id: CCO:F0005058 name: sweet taste receptor activity namespace: molecular_function def: "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah] xref: GO:0033041 is_a: CCO:F0001979 ! taste receptor activity [Term] id: CCO:F0005059 name: umami taste receptor activity namespace: molecular_function def: "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates." [GOC:mah] xref: GO:0033042 is_a: CCO:F0001979 ! taste receptor activity [Term] id: CCO:F0005060 name: putrescine aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H(2)O." [EC:2.6.1.82, GOC:mlg] synonym: "butane-1,4-diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] synonym: "PAT activity" EXACT [] synonym: "putrescine transaminase activity" EXACT [] synonym: "putrescine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.82] synonym: "putrescine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] synonym: "YgjG" RELATED [EC:2.6.1.82] xref: EC:2.6.1.82 xref: GO:0033094 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0005061 name: acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively with an acetylcholine receptor." [GOC:mah] xref: GO:0033130 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005062 name: ubiquitin activating enzyme binding namespace: molecular_function def: "Interacting selectively with a ubiquitin activating enzyme, any of the E1 proteins." [GOC:mah] xref: GO:0033134 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0005063 name: progesterone receptor binding namespace: molecular_function def: "Interacting selectively with a progesterone receptor." [GOC:mah] xref: GO:0033142 is_a: CCO:F0005586 ! steroid hormone receptor binding [Term] id: CCO:F0005064 name: FFAT motif binding namespace: molecular_function def: "Interacting selectively with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family." [PMID:12727870, PMID:15455074, PMID:16004875] xref: GO:0033149 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0005065 name: oligogalacturonide transporting ATPase namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)." [GOC:mlg] xref: GO:0033154 is_a: CCO:F0002841 ! oligosaccharide-transporting ATPase activity is_a: CCO:F0002877 ! oligosaccharide transporting porin activity [Term] id: CCO:F0005066 name: oligogalacturonide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oligogalacturonide from one side of the membrane to the other." [GOC:mlg] xref: GO:0033155 is_a: CCO:F0002634 ! oligosaccharide transmembrane transporter activity [Term] id: CCO:F0005067 name: mitogen-activated protein kinase kinase kinase kinase binding namespace: molecular_function def: "Interacting selectively with a mitogen-activated protein kinase kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase kinase." [GOC:mah] synonym: "MAPKKKK binding" EXACT [] xref: GO:0033161 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0005068 name: glycolipid 6-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,6-D-mannosyl-D-mannose linkage." [EC:2.4.1.232, GOC:mcc, PMID:16878994] synonym: "GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232] synonym: "GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232] synonym: "initiation-specific alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.232] xref: EC:2.4.1.231 xref: GO:0033164 is_a: CCO:F0000003 ! alpha-1,6-mannosyltransferase activity is_a: CCO:F0000794 ! glycolipid mannosyltransferase activity [Term] id: CCO:F0005069 name: DNA-protein loading ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of a protein or protein complex onto a DNA molecule." [GOC:mah, GOC:vw] xref: GO:0033170 is_a: CCO:F0001707 ! DNA-dependent ATPase activity [Term] id: CCO:F0005070 name: inositol hexakisphosphate 4-kinase or 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate or ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [PMID:17412958, PMID:17412959] xref: GO:0033187 is_a: CCO:F0000111 ! inositol hexakisphosphate kinase activity [Term] id: CCO:F0005071 name: sphingomyelin synthase activity namespace: molecular_function def: "Catalysis of the reaction: a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol." [EC:2.7.8.27] synonym: "ceramide:phosphatidylcholine cholinephosphotransferase activity" EXACT [EC:2.7.8.27] synonym: "phosphatidylcholine:ceramide cholinephosphotransferase activity" EXACT [EC:2.7.8.27] synonym: "SM synthase activity" EXACT [EC:2.7.8.27] synonym: "SMS1" RELATED [EC:2.7.8.27] synonym: "SMS2" RELATED [EC:2.7.8.27] xref: EC:2.7.8.27 xref: GO:0033188 is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0005072 name: solanapyrone synthase activity namespace: molecular_function def: "Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A." [GOC:cb, PMID:9659400] xref: GO:0033190 is_a: CCO:F0002427 ! cyclase activity [Term] id: CCO:F0005073 name: macrophomate synthase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate." [ChEBI:38228, GOC:cb, PMID:10984474] xref: GO:0033191 is_a: CCO:F0003320 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: CCO:F0005074 name: calmodulin-dependent protein phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118] synonym: "Ca2+/CaM-dependent protein phosphatase activity" RELATED [] synonym: "calcineurin activity" NARROW [] synonym: "calcium- and calmodulin-dependent protein phosphatase activity" EXACT [] synonym: "calcium/calmodulin-dependent protein phosphatase activity" EXACT [] xref: GO:0033192 is_a: CCO:F0001088 ! calcium-dependent protein serine/threonine phosphatase activity [Term] id: CCO:F0005075 name: tryparedoxin peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: tryparedoxin + H2O2 = tryparedoxin disulfide + H2O." [GOC:mah] synonym: "TXNPx activity" EXACT [] xref: GO:0033196 is_a: CCO:F0008212 ! peroxiredoxin activity [Term] id: CCO:F0005076 name: inositol heptakisphosphate 4-kinase or 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] xref: GO:0033199 is_a: CCO:F0000112 ! inositol heptakisphosphate kinase activity [Term] id: CCO:F0005077 name: inositol heptakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] synonym: "diphosphoinositol-pentakisphosphate 5-kinase activity" EXACT [] synonym: "IP7 5-kinase activity" EXACT [] xref: GO:0033200 is_a: CCO:F0000112 ! inositol heptakisphosphate kinase activity [Term] id: CCO:F0005078 name: alpha-1,4-glucan synthase activity namespace: molecular_function def: "Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP." [PMID:17472966] synonym: "1,4-alpha-glucan synthase activity" EXACT [] xref: GO:0033201 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0005079 name: ribonuclease P RNA binding namespace: molecular_function def: "Interacting selectively with the RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963] synonym: "RNase P RNA binidng" EXACT [] xref: GO:0033204 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0005080 name: beta-1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage." [GOC:mah] synonym: "beta-1,4-GalNAc transferase activity" EXACT [] xref: GO:0033207 is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0005081 name: UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide." [GOC:mah, PMID:12678917, PMID:16024623] synonym: "Sda beta 1,4GalNAc transferase" RELATED [] synonym: "UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] xref: GO:0033208 is_a: CCO:F0005080 ! beta-1,4-N-acetylgalactosaminyltransferase activity [Term] id: CCO:F0005082 name: amide binding namespace: molecular_function def: "Interacting selectively with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [ChEBI:32988, GOC:mah] subset: goslim_pir xref: GO:0033218 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005083 name: urea binding namespace: molecular_function def: "Interacting selectively with urea, a water-soluble carboxamide with the structure H2N-CO-NH2." [ChEBI:16199, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0033219 is_a: CCO:F0005082 ! amide binding [Term] id: CCO:F0005084 name: amide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in)." [GOC:mah] subset: gosubset_prok xref: GO:0033220 is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances is_a: CCO:F0005729 ! amide transporter activity [Term] id: CCO:F0005085 name: urea-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)." [GOC:mlg] subset: gosubset_prok synonym: "carbamide-transporting ATPase activity" EXACT [] xref: GO:0033221 is_a: CCO:F0002676 ! urea transmembrane transporter activity is_a: CCO:F0005084 ! amide-transporting ATPase activity [Term] id: CCO:F0005086 name: xylose binding namespace: molecular_function def: "Interacting selectively with the D- or L-enantiomer of xylose." [GOC:mah] subset: gosubset_prok xref: GO:0033222 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0005087 name: 2-aminoethylphosphonate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of 2-aminoethylphosphonate into, out of, within or between cells." [GOC:mlg] synonym: "2-phosphonoethylamine transmembrane transporter activity" EXACT [] synonym: "ciliatine transporter activity" EXACT [] xref: GO:0033224 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0005088 name: 2-aminoethylphosphonate transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)." [GOC:mlg] synonym: "2-phosphonoethylamine transporting ATPase activity" EXACT [] synonym: "ciliatine transportingATPase activity" EXACT [] xref: GO:0033225 is_a: CCO:F0004647 ! amine-transporting ATPase activity is_a: CCO:F0005087 ! 2-aminoethylphosphonate transmembrane transporter activity [Term] id: CCO:F0005089 name: 2-aminoethylphosphonate binding namespace: molecular_function def: "Interacting selectively with 2-aminoethylphosphonate." [GOC:mlg] synonym: "2-phosphonoethylamine binding" EXACT [] synonym: "ciliatine binding" EXACT [] xref: GO:0033226 is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0005090 name: cysteine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cysteine from one side of the membrane to the other." [GOC:mah] xref: GO:0033229 is_a: CCO:F0000019 ! sulfur amino acid transmembrane transporter activity [Term] id: CCO:F0005091 name: cysteine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)." [GOC:mlg] xref: GO:0033230 is_a: CCO:F0002843 ! amino acid-transporting ATPase activity is_a: CCO:F0005090 ! cysteine transmembrane transporter activity [Term] id: CCO:F0005092 name: D-methionine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)." [GOC:mlg] xref: GO:0033232 is_a: CCO:F0002843 ! amino acid-transporting ATPase activity is_a: CCO:F0007340 ! D-methionine transmembrane transporter activity [Term] id: CCO:F0005093 name: penicillinase activity namespace: molecular_function def: "Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin." [GOC:mlg] xref: GO:0033250 is_a: CCO:F0002144 ! beta-lactamase activity [Term] id: CCO:F0005094 name: cephalosporinase activity namespace: molecular_function def: "Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin." [GOC:mlg] xref: GO:0033251 is_a: CCO:F0002144 ! beta-lactamase activity [Term] id: CCO:F0005095 name: bontoxilysin activity namespace: molecular_function def: "Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." [EC:3.4.24.69] subset: gosubset_prok synonym: "BoNT" RELATED [EC:3.4.24.69] synonym: "botulinum neurotoxin activity" EXACT [] xref: EC:3.4.24.69 xref: GO:0033264 xref: MetaCyc:3.4.24.69-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0005096 name: choline binding namespace: molecular_function def: "Interacting selectively with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [ChEBI:15354, GOC:mlg] xref: GO:0033265 is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0005097 name: choline-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of choline across a membrane." [GOC:mlg] xref: GO:0033266 is_a: CCO:F0002691 ! choline transmembrane transporter activity is_a: CCO:F0004647 ! amine-transporting ATPase activity [Term] id: CCO:F0005098 name: organic acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)." [GOC:mlg] xref: GO:0033283 is_a: CCO:F0001570 ! organic acid transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0005099 name: carboxylic acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)." [GOC:mlg] xref: GO:0033284 is_a: CCO:F0005098 ! organic acid-transporting ATPase activity is_a: CCO:F0006282 ! carboxylic acid transmembrane transporter activity [Term] id: CCO:F0005100 name: monocarboxylic acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)." [GOC:mlg] xref: GO:0033285 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity is_a: CCO:F0005099 ! carboxylic acid-transporting ATPase activity [Term] id: CCO:F0005101 name: ectoine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)." [GOC:mlg] xref: GO:0033286 is_a: CCO:F0005100 ! monocarboxylic acid-transporting ATPase activity is_a: CCO:F0008120 ! ectoine transmembrane transporter activity [Term] id: CCO:F0005102 name: hydroxyectoine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of hydroxyectoine from one side of the membrane to the other." [GOC:mlg] xref: GO:0033287 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0005103 name: hydroxyectoine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)." [GOC:mlg] xref: GO:0033288 is_a: CCO:F0005100 ! monocarboxylic acid-transporting ATPase activity is_a: CCO:F0005102 ! hydroxyectoine transmembrane transporter activity [Term] id: CCO:F0005104 name: monocarboxylic acid binding namespace: molecular_function def: "Interacting selectively with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah] subset: gosubset_prok xref: GO:0033293 is_a: CCO:F0004660 ! carboxylic acid binding [Term] id: CCO:F0005105 name: ectoine binding namespace: molecular_function def: "Interacting selectively with ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid." [GOC:mah] xref: GO:0033294 is_a: CCO:F0005104 ! monocarboxylic acid binding [Term] id: CCO:F0005106 name: hydroxyectoine binding namespace: molecular_function def: "Interacting selectively with hydroxyectoine." [GOC:mlg] xref: GO:0033295 is_a: CCO:F0005104 ! monocarboxylic acid binding [Term] id: CCO:F0005107 name: rhamnose binding namespace: molecular_function def: "Interacting selectively with the D- or L-enantiomer of rhamnose." [GOC:mah] subset: gosubset_prok xref: GO:0033296 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0005108 name: rhamnose-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + rhamnose(out/in) = ADP + phosphate + rhamnose(in/out)." [GOC:mlg] xref: GO:0033297 is_a: CCO:F0002630 ! rhamnose transmembrane transporter activity is_a: CCO:F0002827 ! monosaccharide-transporting ATPase activity [Term] id: CCO:F0005109 name: dehydroascorbic acid transporter activity namespace: molecular_function def: "Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of, within or between cells." [ChEBI:17242] synonym: "dehydroascorbate transporter activity" EXACT [] xref: GO:0033300 is_a: CCO:F0008065 ! vitamin transporter activity [Term] id: CCO:F0005110 name: peroxisome membrane targeting sequence binding namespace: molecular_function def: "Interacting selectively with a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane." [GOC:rb, PMID:15133130] synonym: "mPTS binding" EXACT [] xref: GO:0033328 is_a: CCO:F0000054 ! peroxisome targeting sequence binding [Term] id: CCO:F0005111 name: actin homodimerization activity namespace: molecular_function def: "Interacting selectively with an identical actin monomer to form a homodimer." [GOC:mah] subset: gosubset_prok synonym: "actin dimerization activity" BROAD [] synonym: "actin polymerizing activity" RELATED [] xref: GO:0033392 is_a: CCO:F0005714 ! protein homodimerization activity [Term] id: CCO:F0005112 name: TTT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TTT codon." [GOC:mah] comment: Note that in the standard genetic code, TTT codes for phenylalanine. xref: GO:0033401 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005113 name: TTC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TTC codon." [GOC:mah] comment: Note that in the standard genetic code, TTC codes for phenylalanine. xref: GO:0033402 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005114 name: TTA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TTA codon." [GOC:mah] comment: Note that in the standard genetic code, TTA codes for leucine. xref: GO:0033403 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005115 name: TTG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TTG codon." [GOC:mah] comment: Note that in the standard genetic code, TTG codes for leucine. xref: GO:0033404 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005116 name: TCT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TCT codon." [GOC:mah] comment: Note that in the standard genetic code, TCT codes for serine. xref: GO:0033405 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005117 name: TCC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TCC codon." [GOC:mah] comment: Note that in the standard genetic code, TCC codes for serine. xref: GO:0033406 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005118 name: TCA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TCA codon." [GOC:mah] comment: Note that in the standard genetic code, TCA codes for serine. xref: GO:0033407 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005119 name: TCG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TCG codon." [GOC:mah] comment: Note that in the standard genetic code, TCG codes for serine. xref: GO:0033408 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005120 name: TAT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TAT codon." [GOC:mah] comment: Note that in the standard genetic code, TAT codes for tyrosine. xref: GO:0033409 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005121 name: TAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TAC codon." [GOC:mah] comment: Note that in the standard genetic code, TAC codes for tyrosine. xref: GO:0033410 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005122 name: TAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TAA codon." [GOC:mah] comment: Note that in the standard genetic code, TAA is a stop codon (ochre) and is not normally read by a tRNA. xref: GO:0033411 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005123 name: TAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TAG codon." [GOC:mah] comment: Note that in the standard genetic code, TAG is a stop codon (amber) and is not normally read by a tRNA. xref: GO:0033412 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005124 name: TGT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TGT codon." [GOC:mah] comment: Note that in the standard genetic code, TGT codes for cysteine. xref: GO:0033413 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005125 name: TGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TGC codon." [GOC:mah] comment: Note that in the standard genetic code, TGC codes for cysteine. xref: GO:0033414 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005126 name: TGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TGA codon." [GOC:mah] comment: Note that in the standard genetic code, TGA is a stop codon (opal) and is not normally read by a tRNA. xref: GO:0033415 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005127 name: TGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a TGG codon." [GOC:mah] comment: Note that in the standard genetic code, TGG codes for tryptophan. xref: GO:0033416 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005128 name: CTT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CTT codon." [GOC:mah] comment: Note that in the standard genetic code, CTT codes for leucine. xref: GO:0033417 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005129 name: CTC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CTC codon." [GOC:mah] comment: Note that in the standard genetic code, CTC codes for leucine. xref: GO:0033418 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005130 name: CTA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CTA codon." [GOC:mah] comment: Note that in the standard genetic code, CTA codes for leucine. xref: GO:0033419 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005131 name: CTG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CTG codon." [GOC:mah] comment: Note that in the standard genetic code, CTG codes for leucine. xref: GO:0033420 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005132 name: CCT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCT codon." [GOC:mah] comment: Note that in the standard genetic code, CCT codes for proline. xref: GO:0033421 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005133 name: CCC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCC codon." [GOC:mah] comment: Note that in the standard genetic code, CCC codes for proline. xref: GO:0033422 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005134 name: CCA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCA codon." [GOC:mah] comment: Note that in the standard genetic code, CCA codes for proline. xref: GO:0033423 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005135 name: CCG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCG codon." [GOC:mah] comment: Note that in the standard genetic code, CCG codes for proline. xref: GO:0033424 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005136 name: CAT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAT codon." [GOC:mah] comment: Note that in the standard genetic code, CAT codes for histidine. xref: GO:0033425 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005137 name: CAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAC codon." [GOC:mah] comment: Note that in the standard genetic code, CAC codes for histidine. xref: GO:0033426 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005138 name: CAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAA codon." [GOC:mah] comment: Note that in the standard genetic code, CAA codes for glutamine. xref: GO:0033427 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005139 name: CAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAG codon." [GOC:mah] comment: Note that in the standard genetic code, CAG codes for glutamine. xref: GO:0033428 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005140 name: CGT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGT codon." [GOC:mah] comment: Note that in the standard genetic code, CGT codes for arginine. xref: GO:0033429 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005141 name: CGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGC codon." [GOC:mah] comment: Note that in the standard genetic code, CGC codes for arginine. xref: GO:0033430 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005142 name: CGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGA codon." [GOC:mah] comment: Note that in the standard genetic code, CGA codes for arginine. xref: GO:0033431 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005143 name: CGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGG codon." [GOC:mah] comment: Note that in the standard genetic code, CGG codes for arginine. xref: GO:0033432 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005144 name: ATT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ATT codon." [GOC:mah] comment: Note that in the standard genetic code, ATT codes for isoleucine. xref: GO:0033433 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005145 name: ATC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ATC codon." [GOC:mah] comment: Note that in the standard genetic code, ATC codes for isoleucine. xref: GO:0033434 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005146 name: ATA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ATA codon." [GOC:mah] comment: Note that in the standard genetic code, ATA codes for isoleucine. xref: GO:0033435 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005147 name: ATG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ATG codon." [GOC:mah] comment: Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon. xref: GO:0033436 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005148 name: ACT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACT codon." [GOC:mah] comment: Note that in the standard genetic code, ACT codes for threonine. xref: GO:0033437 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005149 name: ACC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACC codon." [GOC:mah] comment: Note that in the standard genetic code, ACC codes for threonine. xref: GO:0033438 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005150 name: ACA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACA codon." [GOC:mah] comment: Note that in the standard genetic code, ACA codes for threonine. xref: GO:0033439 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005151 name: ACG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACG codon." [GOC:mah] comment: Note that in the standard genetic code, ACG codes for threonine. xref: GO:0033440 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005152 name: AAT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAT codon." [GOC:mah] comment: Note that in the standard genetic code, AAT codes for asparagine. xref: GO:0033441 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005153 name: AAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAC codon." [GOC:mah] comment: Note that in the standard genetic code, AAC codes for asparagine. xref: GO:0033442 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005154 name: AAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAA codon." [GOC:mah] comment: Note that in the standard genetic code, AAA codes for lysine. xref: GO:0033443 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005155 name: AAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAG codon." [GOC:mah] comment: Note that in the standard genetic code, AAG codes for lysine. xref: GO:0033444 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005156 name: AGT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGT codon." [GOC:mah] comment: Note that in the standard genetic code, AGT codes for serine. xref: GO:0033445 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005157 name: AGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGC codon." [GOC:mah] comment: Note that in the standard genetic code, AGC codes for serine. xref: GO:0033446 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005158 name: AGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGA codon." [GOC:mah] comment: Note that in the standard genetic code, AGA codes for arginine. xref: GO:0033447 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005159 name: AGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGG codon." [GOC:mah] comment: Note that in the standard genetic code, AGG codes for arginine. xref: GO:0033448 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005160 name: GTT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GTT codon." [GOC:mah] comment: Note that in the standard genetic code, GTT codes for valine. xref: GO:0033449 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005161 name: GTC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GTC codon." [GOC:mah] comment: Note that in the standard genetic code, GTC codes for valine. xref: GO:0033450 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005162 name: GTA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GTA codon." [GOC:mah] comment: Note that in the standard genetic code, GTA codes for valine. xref: GO:0033451 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005163 name: GTG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GTG codon." [GOC:mah] comment: Note that in the standard genetic code, GTG codes for valine. xref: GO:0033452 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005164 name: GCT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCT codon." [GOC:mah] comment: Note that in the standard genetic code, GCT codes for alanine. xref: GO:0033453 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005165 name: GCC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCC codon." [GOC:mah] comment: Note that in the standard genetic code, GCC codes for alanine. xref: GO:0033454 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005166 name: GCA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCA codon." [GOC:mah] comment: Note that in the standard genetic code, GCA codes for alanine. xref: GO:0033455 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005167 name: GCG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCG codon." [GOC:mah] comment: Note that in the standard genetic code, GCG codes for alanine. xref: GO:0033456 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005168 name: GAT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAT codon." [GOC:mah] comment: Note that in the standard genetic code, GAT codes for acid. xref: GO:0033457 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005169 name: GAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAC codon." [GOC:mah] comment: Note that in the standard genetic code, GAC codes for acid. xref: GO:0033458 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005170 name: GAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAA codon." [GOC:mah] comment: Note that in the standard genetic code, GAA codes for acid. xref: GO:0033459 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005171 name: GAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAG codon." [GOC:mah] comment: Note that in the standard genetic code, GAG codes for acid. xref: GO:0033460 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005172 name: GGT codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGT codon." [GOC:mah] comment: Note that in the standard genetic code, GGT codes for glycine. xref: GO:0033461 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005173 name: GGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGC codon." [GOC:mah] comment: Note that in the standard genetic code, GGC codes for glycine. xref: GO:0033462 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005174 name: GGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGA codon." [GOC:mah] comment: Note that in the standard genetic code, GGA codes for glycine. xref: GO:0033463 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005175 name: GGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGG codon." [GOC:mah] comment: Note that in the standard genetic code, GGG codes for glycine. xref: GO:0033464 is_a: CCO:F0004455 ! triplet codon-amino acid adaptor activity [Term] id: CCO:F0005176 name: MAP kinase phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah] xref: GO:0033549 is_a: CCO:F0001086 ! phosphoprotein phosphatase activity [Term] id: CCO:F0005177 name: MAP kinase tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate." [GOC:mah] synonym: "tyrosine-specific MAP kinase phosphatase activity" EXACT [] xref: GO:0033550 is_a: CCO:F0001090 ! protein tyrosine phosphatase activity is_a: CCO:F0005176 ! MAP kinase phosphatase activity [Term] id: CCO:F0005178 name: dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol." [GOC:mah, PMID:10336995] synonym: "dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: EC:2.4.1.- xref: GO:0033556 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005179 name: protein deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate." [GOC:mah] xref: GO:0033558 is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0005180 name: folate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pd] subset: gosubset_prok xref: GO:0033560 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005181 name: lactoferrin receptor activity namespace: molecular_function def: "Combining with lactoferrin to initiate a change in cell activity." [GOC:mlg] xref: GO:0033568 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0005182 name: lactoferrin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg] xref: GO:0033569 is_a: CCO:F0002571 ! ferric iron transmembrane transporter activity is_a: CCO:F0002860 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: CCO:F0005183 name: transferrin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of transferrin from one side of a membrane to the other." [GOC:mlg] xref: GO:0033570 is_a: CCO:F0002571 ! ferric iron transmembrane transporter activity is_a: CCO:F0002860 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: CCO:F0005184 name: RNA strand annealing activity namespace: molecular_function def: "Facilitates the base-pairing of complementary single-stranded RNA." [GOC:mah] xref: GO:0033592 is_a: CCO:F0000310 ! double-stranded RNA binding is_a: CCO:F0000312 ! single-stranded RNA binding [Term] id: CCO:F0005185 name: formyl-CoA transferase activity namespace: molecular_function def: "Catalysis of the reaction formyl-CoA + oxalate = formate + oxalyl-CoA." [EC:2.8.3.16, GOC:mlg] synonym: "formyl-CoA oxalate CoA-transferase activity" EXACT [EC:2.8.3.16] synonym: "formyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.16] synonym: "formyl-coenzyme A transferase activity" EXACT [EC:2.8.3.16] xref: EC:2.8.3.16 xref: GO:0033608 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0005186 name: receptor serine/threonine kinase binding namespace: molecular_function def: "Interacting selectively with a receptor that possesses protein serine/threonine kinase activity." [GOC:mah] synonym: "transmembrane receptor protein serine/threonine kinase ligand binding" RELATED [] xref: GO:0033612 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005187 name: transcription activator binding namespace: molecular_function def: "Interacting selectively with a transcription activator, any protein whose activity is required to initiate or upregulate transcription." [GOC:mah] xref: GO:0033613 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005188 name: double-stranded DNA-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of double-stranded DNA; drives another reaction." [GOC:mah] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "dsDNA-dependent ATPase activity" EXACT [] xref: GO:0033676 is_a: CCO:F0001707 ! DNA-dependent ATPase activity [Term] id: CCO:F0005189 name: DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA." [GOC:mah] comment: Consider also annotating to the molecular function term 'RNA binding ; GO:0003723'. subset: gosubset_prok xref: EC:2.7.7.- xref: GO:0033677 xref: Reactome:7008 is_a: CCO:F0000803 ! helicase activity [Term] id: CCO:F0005190 name: 5'-3' DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah] synonym: "5' to 3' DNA/RNA helicase activity" EXACT [] xref: GO:0033678 is_a: CCO:F0005189 ! DNA/RNA helicase activity [Term] id: CCO:F0005191 name: 3'-5' DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah] synonym: "3' to 5' DNA/RNA helicase activity" EXACT [] xref: GO:0033679 is_a: CCO:F0005189 ! DNA/RNA helicase activity [Term] id: CCO:F0005192 name: ATP-dependent DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of a DNA/RNA duplex." [GOC:mah] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok xref: GO:0033680 is_a: CCO:F0001682 ! ATP-dependent helicase activity is_a: CCO:F0001707 ! DNA-dependent ATPase activity is_a: CCO:F0005189 ! DNA/RNA helicase activity [Term] id: CCO:F0005193 name: ATP-dependent 3'-5' DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah] synonym: "ATP-dependent 3' to 5' DNA/RNA helicase activity" EXACT [] xref: GO:0033681 is_a: CCO:F0005191 ! 3'-5' DNA/RNA helicase activity is_a: CCO:F0005192 ! ATP-dependent DNA/RNA helicase activity [Term] id: CCO:F0005194 name: ATP-dependent 5'-3' DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah] synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT [] xref: GO:0033682 is_a: CCO:F0005190 ! 5'-3' DNA/RNA helicase activity is_a: CCO:F0005192 ! ATP-dependent DNA/RNA helicase activity [Term] id: CCO:F0005195 name: sialic acid binding namespace: molecular_function def: "Interacting selectively with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria." [GOC:add, http:en.wikipedia.org, http:www.biology-online.org, ISBN:0721601465] synonym: "N-acetylneuraminic acid binding" NARROW [] xref: GO:0033691 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0005196 name: oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok xref: EC:1.5.7 xref: GO:0033694 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0005197 name: oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule." [EC:1.17.5, GOC:mah] subset: gosubset_prok xref: EC:1.17.5 xref: GO:0033695 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0005198 name: DNA 5'-adenosine monophosphate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." [GOC:mah, PMID:16547001, PMID:17276982] synonym: "AMP-removal activity" RELATED [] synonym: "DNA 5'-adenylate hydrolase activity" EXACT [] synonym: "DNA adenylate hydrolysis activity" BROAD [] synonym: "DNA de-adenylation" RELATED [] synonym: "DNA deadenylation" RELATED [] xref: GO:0033699 is_a: CCO:F0005595 ! 5'-3' exodeoxyribonuclease activity [Term] id: CCO:F0005199 name: dTDP-galactose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+." [EC:1.1.1.186] synonym: "dTDP-D-galactose:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.186] synonym: "dTDPgalactose 6-dehydrogenase activity" EXACT [EC:1.1.1.186] synonym: "thymidine-diphosphate-galactose dehydrogenase activity" EXACT [EC:1.1.1.186] xref: EC:1.1.1.186 xref: GO:0033701 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005201 name: 3beta-hydroxy-5beta-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + NADPH + H+." [EC:1.1.1.277] synonym: "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.277] synonym: "3beta-hydroxysteroid 5beta-oxidoreductase activity" EXACT [EC:1.1.1.277] synonym: "3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity" EXACT [EC:1.1.1.277] xref: EC:1.1.1.277 xref: GO:0033703 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005202 name: 3beta-hydroxy-5alpha-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnan-3,20-dione + NADPH + H+." [EC:1.1.1.278] synonym: "3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.278] xref: EC:1.1.1.278 xref: GO:0033704 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005203 name: GDP-4-dehydro-6-deoxy-D-mannose reductase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+." [EC:1.1.1.281] comment: Note that this enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose). synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" BROAD [EC:1.1.1.281] synonym: "GDP-6-deoxy-D-lyxo-4-hexulose reductase activity" EXACT [EC:1.1.1.281] synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity" EXACT [EC:1.1.1.281] synonym: "Rmd" RELATED [EC:1.1.1.281] xref: EC:1.1.1.281 xref: GO:0033705 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005204 name: quinate/shikimate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+ and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+." [EC:1.1.1.282] synonym: "L-quinate:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.1.1.282] synonym: "YdiB" RELATED [EC:1.1.1.282] xref: EC:1.1.1.282 xref: GO:0033706 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005205 name: 3''-deamino-3''-oxonicotianamine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+." [EC:1.1.1.285] synonym: "2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity" EXACT [EC:1.1.1.285] xref: EC:1.1.1.285 xref: GO:0033707 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005206 name: isocitrate-homoisocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+." [EC:1.1.1.286] synonym: "homoisocitrate-isocitrate dehydrogenase activity" EXACT [EC:1.1.1.286] synonym: "isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.286] synonym: "PH1722" RELATED [EC:1.1.1.286] xref: EC:1.1.1.286 xref: GO:0033708 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005207 name: D-arabinitol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reactions: D-arabinitol + NADP+ = D-xylulose + NADPH + H+ and D-arabinitol + NADP+ = D-ribulose + NADPH + H+." [EC:1.1.1.287] synonym: "ARD1p" RELATED [EC:1.1.1.287] synonym: "D-arabinitol dehydrogenase 1 activity" NARROW [EC:1.1.1.287] synonym: "D-arabinitol:NADP+ dehydrogenase activity" EXACT [EC:1.1.1.287] synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" EXACT [EC:1.1.1.287] xref: EC:1.1.1.287 xref: GO:0033709 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005208 name: 4-phosphoerythronate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH + H+." [EC:1.1.1.290] synonym: "4-O-phosphoerythronate dehydrogenase activity" EXACT [EC:1.1.1.290] synonym: "4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.290] synonym: "4PE dehydrogenase activity" EXACT [EC:1.1.1.290] synonym: "erythronate-4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.290] synonym: "PdxB" RELATED [EC:1.1.1.290] synonym: "PdxB 4PE dehydrogenase activity" EXACT [EC:1.1.1.290] xref: EC:1.1.1.290 xref: GO:0033711 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005209 name: 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+." [EC:1.1.1.292] synonym: "1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.292] synonym: "AFR" RELATED [EC:1.1.1.292] xref: EC:1.1.1.292 xref: GO:0033712 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005210 name: choline:oxygen 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: choline + O2 = betaine aldehyde + H2O2." [EC:1.1.3.17] synonym: "choline oxidase activity" BROAD [EC:1.1.3.17] xref: EC:1.1.3.17 xref: GO:0033713 is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0005211 name: secondary-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a secondary alcohol + O2 = a ketone + H2O2." [EC:1.1.3.18] synonym: "polyvinyl alcohol oxidase activity" EXACT [EC:1.1.3.18] synonym: "secondary alcohol oxidase activity" EXACT [EC:1.1.3.18] synonym: "secondary-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.18] xref: EC:1.1.3.18 xref: GO:0033714 is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0005212 name: nucleoside oxidase activity namespace: molecular_function def: "Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O and (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O." [EC:1.1.3.28] synonym: "nucleoside:oxygen 5'-oxidoreductase activity" EXACT [EC:1.1.3.28] xref: EC:1.1.3.28 xref: GO:0033715 is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0005213 name: nucleoside oxidase (H2O2-forming) activity namespace: molecular_function def: "Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 H2O2, (1a) adenosine + O2 = 5'-dehydroadenosine + H2O2 and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + H2O2." [EC:1.1.3.39] synonym: "nucleoside:oxygen 5'-oxidoreductase (H2O2-forming) activity" EXACT [EC:1.1.3.39] xref: EC:1.1.3.39 xref: GO:0033716 is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0005214 name: gluconate 2-dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor." [EC:1.1.99.3] synonym: "2-ketogluconate reductase activity" BROAD [EC:1.1.99.3] synonym: "D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.3] synonym: "D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity" EXACT [EC:1.1.99.3] synonym: "D-gluconate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.3] synonym: "D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.3] synonym: "gluconate oxidase activity" EXACT [EC:1.1.99.3] synonym: "gluconic acid dehydrogenase activity" EXACT [EC:1.1.99.3] synonym: "gluconic dehydrogenase activity" EXACT [EC:1.1.99.3] xref: EC:1.1.99.3 xref: GO:0033717 is_a: CCO:F0002213 ! gluconate dehydrogenase activity [Term] id: CCO:F0005215 name: pyranose dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor." [EC:1.1.99.29] synonym: "PDH" RELATED [EC:1.1.99.29] synonym: "pyranose dehydrogenase activity" EXACT [EC:1.1.99.29] synonym: "pyranose-quinone oxidoreductase activity" EXACT [EC:1.1.99.29] synonym: "pyranose:acceptor oxidoreductase activity" EXACT [EC:1.1.99.29] synonym: "quinone-dependent pyranose dehydrogenase activity" EXACT [EC:1.1.99.29] xref: EC:1.1.99.29 xref: GO:0033718 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0005216 name: 2-oxo-acid reductase activity namespace: molecular_function def: "Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor." [EC:1.1.99.30] synonym: "(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.30] synonym: "(2R)-hydroxycarboxylate-viologen-oxidoreductase activity" EXACT [EC:1.1.99.30] synonym: "2-oxoacid reductase activity" EXACT [EC:1.1.99.30] synonym: "HVOR" RELATED [EC:1.1.99.30] xref: EC:1.1.99.30 xref: GO:0033719 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0005218 name: aldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+." [EC:1.2.1.4] synonym: "aldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.4] synonym: "NADP-acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.4] synonym: "NADP-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.4] xref: EC:1.2.1.4 xref: GO:0033721 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005219 name: malonate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+." [EC:1.2.1.15] synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.15] synonym: "malonic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.15] xref: EC:1.2.1.15 xref: GO:0033722 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005220 name: fluoroacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+." [EC:1.2.1.69] synonym: "fluoroacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.69] xref: EC:1.2.1.69 xref: GO:0033723 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005221 name: aldehyde ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.5] synonym: "aldehyde:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5] synonym: "AOR" RELATED [EC:1.2.7.5] synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5] xref: EC:1.2.7.5 xref: GO:0033726 is_a: CCO:F0003227 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0005222 name: aldehyde dehydrogenase (FAD-independent) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor." [EC:1.2.99.7] synonym: "aldehyde oxidoreductase activity" EXACT [EC:1.2.99.7] synonym: "aldehyde:acceptor oxidoreductase (FAD-independent) activity" EXACT [EC:1.2.99.7] synonym: "AORDd" RELATED [EC:1.2.99.7] synonym: "Mop" RELATED [EC:1.2.99.7] xref: EC:1.2.99.7 xref: GO:0033727 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0005223 name: divinyl chlorophyllide a 8-vinyl-reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+." [EC:1.3.1.75] synonym: "4VCR" RELATED [EC:1.3.1.75] synonym: "[4-vinyl]chlorophyllide a reductase activity" EXACT [EC:1.3.1.75] synonym: "chlorophyllide-a:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.75] xref: EC:1.3.1.75 xref: GO:0033728 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005224 name: anthocyanidin reductase activity namespace: molecular_function def: "Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+." [EC:1.3.1.77] synonym: "ANR" RELATED [EC:1.3.1.77] synonym: "AtANR" RELATED [EC:1.3.1.77] synonym: "flavan-3-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.77] synonym: "MtANR" RELATED [EC:1.3.1.77] xref: EC:1.3.1.77 xref: GO:0033729 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005225 name: arogenate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2." [EC:1.3.1.78] synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.78] synonym: "L-arogenate:NADP+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.78] synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.78] synonym: "TyrAa" RELATED [EC:1.3.1.78] synonym: "TyrAAT1" RELATED [EC:1.3.1.78] synonym: "TyrAAT2" RELATED [EC:1.3.1.78] xref: EC:1.3.1.78 xref: GO:0033730 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005226 name: arogenate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2." [EC:1.3.1.79] synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.79] synonym: "L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.79] synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.79] xref: EC:1.3.1.79 xref: GO:0033731 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005227 name: pyrroloquinoline-quinone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O." [EC:1.3.3.11] synonym: "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.3.3.11] synonym: "PqqC" RELATED [EC:1.3.3.11] xref: EC:1.3.3.11 xref: GO:0033732 is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0005229 name: aspartate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+." [EC:1.4.1.21] synonym: "L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.21] synonym: "NAD-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] synonym: "NADH2-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] synonym: "NADP+-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] xref: EC:1.4.1.21 xref: GO:0033735 is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0005230 name: L-lysine 6-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + O2 + H2O = 2-aminoadipate 6-semialdehyde + H2O2 + NH3." [EC:1.4.3.20] synonym: "L-lysine-epsilon-oxidase activity" EXACT [EC:1.4.3.20] synonym: "L-lysine:oxygen 6-oxidoreductase (deaminating) activity" EXACT [EC:1.4.3.20] synonym: "Lod" RELATED [EC:1.4.3.20] synonym: "LodA" RELATED [EC:1.4.3.20] synonym: "marinocine" RELATED [EC:1.4.3.20] xref: EC:1.4.3.20 xref: GO:0033736 is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0005231 name: 1-pyrroline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.5.1.35] synonym: "1-pyrroline:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.35] synonym: "ABALDH" RELATED [EC:1.5.1.35] synonym: "gamma-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.5.1.35] synonym: "YdcW" RELATED [EC:1.5.1.35] xref: EC:1.5.1.35 xref: GO:0033737 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005232 name: methylenetetrahydrofolate reductase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin." [EC:1.5.7.1] synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1] synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" EXACT [EC:1.5.7.1] xref: EC:1.5.7.1 xref: GO:0033738 is_a: CCO:F0005196 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0005233 name: queuine synthase activity namespace: molecular_function def: "Catalysis of the reaction: queuine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+." [EC:1.7.1.13] synonym: "7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.13] synonym: "7-cyano-7-deazaguanine reductase activity" EXACT [EC:1.7.1.13] synonym: "preQ0 oxidoreductase activity" EXACT [EC:1.7.1.13] synonym: "preQ0 reductase activity" EXACT [EC:1.7.1.13] synonym: "QueF" RELATED [EC:1.7.1.13] synonym: "queuine:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.13] synonym: "YkvM" RELATED [EC:1.7.1.13] xref: EC:1.7.1.13 xref: GO:0033739 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor is_a: CCO:F0003255 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: CCO:F0005234 name: hydroxylamine oxidoreductase activity namespace: molecular_function def: "Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O and hydrazine + acceptor = N2 + reduced acceptor." [EC:1.7.99.8] synonym: "hydroxylamine:acceptor oxidoreductase activity" EXACT [EC:1.7.99.8] xref: EC:1.7.99.8 xref: GO:0033740 is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005235 name: adenylyl-sulfate reductase (glutathione) activity namespace: molecular_function def: "Catalysis of the reaction: AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione." [EC:1.8.4.9] synonym: "5'-adenylylsulfate reductase activity" EXACT [EC:1.8.4.9] synonym: "AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9] synonym: "AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9] synonym: "plant-type 5'-adenylylsulfate reductase activity" NARROW [EC:1.8.4.9] xref: EC:1.8.4.9 xref: GO:0033741 is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0005236 name: peptide-methionine (R)-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.12] synonym: "methionine S-oxide reductase (R-form oxidizing) activity" EXACT [EC:1.8.4.12] synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.12] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.12] synonym: "methionine sulfoxide reductase B activity" NARROW [EC:1.8.4.12] synonym: "MsrB" RELATED [EC:1.8.4.12] synonym: "peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.12] synonym: "PilB" RELATED [EC:1.8.4.12] synonym: "pMRsr" RELATED [EC:1.8.4.12] synonym: "pMSR" RELATED [EC:1.8.4.12] synonym: "selenoprotein R" RELATED [EC:1.8.4.12] synonym: "SelR" RELATED [EC:1.8.4.12] synonym: "SelX" RELATED [EC:1.8.4.12] xref: EC:1.8.4.12 xref: GO:0033743 is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0005237 name: L-methionine-(S)-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.13] synonym: "acetylmethionine sulfoxide reductase activity" EXACT [EC:1.8.4.13] synonym: "free-methionine (S)-S-oxide reductase activity" EXACT [EC:1.8.4.13] synonym: "fSMsr" RELATED [EC:1.8.4.13] synonym: "L-methionine:oxidized-thioredoxin S-oxidoreductase activity" EXACT [EC:1.8.4.13] synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.13] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.13] synonym: "methyl sulfoxide reductase I and II activity" EXACT [EC:1.8.4.13] xref: EC:1.8.4.13 xref: GO:0033744 is_a: CCO:F0000066 ! methionine-S-oxide reductase activity [Term] id: CCO:F0005238 name: L-methionine-(R)-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.14] synonym: "free met-R-(o) reductase activity" EXACT [EC:1.8.4.14] synonym: "free-methionine (R)-S-oxide reductase activity" EXACT [EC:1.8.4.14] synonym: "fRMsr" RELATED [EC:1.8.4.14] synonym: "FRMsr" RELATED [EC:1.8.4.14] synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.14] xref: EC:1.8.4.14 xref: GO:0033745 is_a: CCO:F0000066 ! methionine-S-oxide reductase activity [Term] id: CCO:F0005239 name: histone demethylase activity (H3-R2 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein." [GOC:mah] xref: GO:0033746 is_a: CCO:F0004998 ! histone demethylase activity [Term] id: CCO:F0005240 name: versatile peroxidase activity namespace: molecular_function def: "Catalysis of the reactions: Reactive Black 5 + H2O2 = oxidized Reactive Black 5 + 2 H2O and donor + H2O2 = oxidized donor + 2 H2O." [EC:1.11.1.16] synonym: "hybrid peroxidase activity" EXACT [EC:1.11.1.16] synonym: "polyvalent peroxidase activity" EXACT [EC:1.11.1.16] synonym: "reactive-black-5:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.16] synonym: "VP" RELATED [EC:1.11.1.16] xref: EC:1.11.1.16 xref: GO:0033747 is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0005241 name: hydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: H2 + A = AH2." [EC:1.12.99.6] synonym: "H2 producing hydrogenase activity" BROAD [EC:1.12.99.6] synonym: "hydrogen-lyase activity" BROAD [EC:1.12.99.6] synonym: "hydrogen:(acceptor) oxidoreductase activity" EXACT [EC:1.12.99.6] synonym: "hydrogen:acceptor oxidoreductase activity" EXACT [EC:1.12.99.6] synonym: "hydrogenlyase activity" BROAD [EC:1.12.99.6] synonym: "uptake hydrogenase activity" BROAD [EC:1.12.99.6] xref: EC:1.12.99.6 xref: GO:0033748 is_a: CCO:F0003281 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: CCO:F0005242 name: histone demethylase activity (H4-R3 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein." [GOC:mah] xref: GO:0033749 is_a: CCO:F0004998 ! histone demethylase activity [Term] id: CCO:F0005243 name: linoleate diol synthase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate." [EC:1.13.11.44] synonym: "linoleate (8R)-dioxygenase activity" EXACT [EC:1.13.11.44] synonym: "linoleate 8-dioxygenase activity" EXACT [EC:1.13.11.44] synonym: "linoleate:oxygen 7S,8S-oxidoreductase activity" EXACT [EC:1.13.11.44] xref: EC:1.13.11.44 xref: GO:0033751 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0005244 name: acetylacetone-cleaving enzyme activity namespace: molecular_function def: "Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal." [EC:1.13.11.50] synonym: "acetylacetone dioxygenase activity" EXACT [EC:1.13.11.50] synonym: "acetylacetone-cleaving enzyme" RELATED [EC:1.13.11.50] synonym: "acetylacetone:oxygen oxidoreductase activity" EXACT [EC:1.13.11.50] synonym: "diketone cleaving dioxygenase activity" EXACT [EC:1.13.11.50] synonym: "diketone cleaving enzyme" RELATED [EC:1.13.11.50] synonym: "Dke1" RELATED [EC:1.13.11.50] xref: EC:1.13.11.50 xref: GO:0033752 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0005245 name: indoleamine 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.52] synonym: "D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity" NARROW [EC:1.13.11.52] synonym: "IDO" RELATED [EC:1.13.11.52] synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52] xref: EC:1.13.11.52 xref: GO:0033754 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0005246 name: sulfur oxygenase/reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+." [EC:1.13.11.55] synonym: "SOR" RELATED [EC:1.13.11.55] synonym: "sulfur oxygenase activity" BROAD [EC:1.13.11.55] synonym: "sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity" EXACT [EC:1.13.11.55] synonym: "sulphur oxygenase/reductase activity" EXACT [] xref: EC:1.13.11.55 xref: GO:0033755 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0005247 name: Oplophorus-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu." [EC:1.13.12.13] synonym: "Oplophorus luciferase activity" EXACT [EC:1.13.12.13] synonym: "Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity" EXACT [EC:1.13.12.13] xref: EC:1.13.12.13 xref: GO:0033756 is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: CCO:F0006100 ! luciferin monooxygenase activity [Term] id: CCO:F0005248 name: glucoside 3-dehydrogenase namespace: molecular_function def: "Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor." [EC:1.1.99.13] synonym: "D-aldohexopyranoside dehydrogenase" EXACT [EC:1.1.99.13] synonym: "D-aldohexoside:(acceptor) 3-oxidoreductase" EXACT [EC:1.1.99.13] synonym: "D-aldohexoside:acceptor 3-oxidoreductase" EXACT [EC:1.1.99.13] synonym: "D-aldohexoside:cytochrome c oxidoreductase" EXACT [EC:1.1.99.13] synonym: "hexopyranoside-cytochrome c oxidoreductase" EXACT [EC:1.1.99.13] xref: EC:1.1.99.13 xref: GO:0033757 xref: MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0005249 name: clavaminate synthase activity namespace: molecular_function def: "Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O and proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O." [EC:1.14.11.21] synonym: "clavaminate synthase 2 activity" NARROW [EC:1.14.11.21] synonym: "clavaminic acid synthase activity" EXACT [EC:1.14.11.21] synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.21] xref: EC:1.14.11.21 xref: GO:0033758 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0005250 name: flavone synthase activity namespace: molecular_function def: "Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O." [EC:1.14.11.22] synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity" EXACT [EC:1.14.11.22] synonym: "flavone synthase I activity" EXACT [EC:1.14.11.22] synonym: "FNS I" RELATED [EC:1.14.11.22] xref: EC:1.14.11.22 xref: GO:0033759 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0005251 name: 2'-deoxymugineic-acid 2'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = mugineic acid + succinate + CO2." [EC:1.14.11.24] synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity" EXACT [EC:1.14.11.24] synonym: "IDS3" RELATED [EC:1.14.11.24] xref: EC:1.14.11.24 xref: GO:0033760 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0005252 name: mugineic-acid 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2 and 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2." [EC:1.14.11.25] synonym: "IDS2" RELATED [EC:1.14.11.25] synonym: "mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.25] xref: EC:1.14.11.25 xref: GO:0033761 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0005253 name: proline 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.28] synonym: "L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.28] synonym: "P-3-H" RELATED [EC:1.14.11.28] xref: EC:1.14.11.28 xref: GO:0033763 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0005254 name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative." [GOC:mah] subset: gosubset_prok xref: EC:1.1.1.- xref: GO:0033764 is_a: CCO:F0003082 ! steroid dehydrogenase activity is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005255 name: steroid dehydrogenase activity, acting on the CH-CH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative." [GOC:mah] subset: gosubset_prok xref: EC:1.1.1.- xref: GO:0033765 is_a: CCO:F0003082 ! steroid dehydrogenase activity is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0005256 name: 2-hydroxyquinoline 8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = quinolin-2,8-diol + NAD+ + H2O." [EC:1.14.13.61] synonym: "2-oxo-1,2-dihydroquinoline 8-monooxygenase activity" EXACT [EC:1.14.13.61] synonym: "quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity" EXACT [EC:1.14.13.61] xref: EC:1.14.13.61 xref: GO:0033766 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005257 name: 4-hydroxyacetophenone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4-hydroxyphenyl)ethan-1-one + NADPH + H+ + O2 = 4-hydroxyphenyl acetate + NADP+ + H2O." [EC:1.14.13.80, EC:1.14.13.84] synonym: "(+)-limonene 6-monooxygenase activity" EXACT [EC:1.14.13.80] synonym: "(+)-limonene-6-hydroxylase activity" EXACT [EC:1.14.13.80] synonym: "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity" EXACT [EC:1.14.13.84] synonym: "(R)-limonene 6-monooxygenase activity" EXACT [EC:1.14.13.80] synonym: "(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.80] synonym: "HAPMO" RELATED [EC:1.14.13.84] xref: EC:1.14.13.80 xref: EC:1.14.13.84 xref: GO:0033767 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005258 name: glyceollin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O." [EC:1.14.13.85] synonym: "2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.14.13.85] synonym: "dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity" EXACT [EC:1.14.13.85] xref: EC:1.14.13.85 xref: GO:0033769 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005259 name: 2-hydroxyisoflavanone synthase activity namespace: molecular_function def: "Catalysis of the reaction: apigenin + 2 NADPH + 2 H+ + O2 = 2-hydroxy-2,3-dihydrogenistein + 2 NADP+ + H2O." [EC:1.14.13.86] synonym: "2-HIS" RELATED [EC:1.14.13.86] synonym: "apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming) activity" EXACT [EC:1.14.13.86] xref: EC:1.14.13.86 xref: GO:0033770 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005260 name: licodione synthase activity namespace: molecular_function def: "Catalysis of the reaction: liquiritigenin + NADPH + H+ + O2 = licodione + NADP+ + H2O." [EC:1.14.13.87] synonym: "(2S)-flavanone 2-hydroxylase activity" EXACT [EC:1.14.13.87] synonym: "liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity" EXACT [EC:1.14.13.87] xref: EC:1.14.13.87 xref: GO:0033771 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005261 name: flavonoid 3',5'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O." [EC:1.14.13.88] synonym: "F3',5'H" RELATED [EC:1.14.13.88] synonym: "F3'5'H" RELATED [EC:1.14.13.88] synonym: "flavanone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.88] xref: EC:1.14.13.88 xref: GO:0033772 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005262 name: isoflavone 2'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: an isoflavone + NADPH + H+ + O2 = a 2'-hydroxyisoflavone + NADP+ + H2O." [EC:1.14.13.89] synonym: "CYP Ge-3" RELATED [EC:1.14.13.89] synonym: "CYP81E1" RELATED [EC:1.14.13.89] synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.89] synonym: "isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating) activity" EXACT [EC:1.14.13.89] xref: EC:1.14.13.89 xref: GO:0033773 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005263 name: deoxysarpagine hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deoxysarpagine + NADPH + H+ + O2 = sarpagine + NADP+ + H2O." [EC:1.14.13.91] synonym: "10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity" EXACT [EC:1.14.13.91] synonym: "DOSH" RELATED [EC:1.14.13.91] xref: EC:1.14.13.91 xref: GO:0033775 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005264 name: phenylacetone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetone + NADPH + H+ + O2 = benzyl acetate + NADP+ + H2O." [EC:1.14.13.92] synonym: "PAMO" RELATED [EC:1.14.13.92] synonym: "phenylacetone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.92] xref: EC:1.14.13.92 xref: GO:0033776 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005265 name: lithocholate 6beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: lithocholate + NADPH + H+ + O2 = 6beta-hydroxylithocholate + NADP+ + H2O." [EC:1.14.13.94] synonym: "6beta-hydroxylase activity" BROAD [EC:1.14.13.94] synonym: "CYP3A10" RELATED [EC:1.14.13.94] synonym: "cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity" EXACT [EC:1.14.13.94] synonym: "lithocholate 6beta-monooxygenase activity" EXACT [EC:1.14.13.94] synonym: "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity" EXACT [EC:1.14.13.94] xref: EC:1.14.13.94 xref: GO:0033777 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005266 name: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O." [EC:1.14.13.95] synonym: "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity" EXACT [EC:1.14.13.95] synonym: "7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.95] synonym: "CYP12" RELATED [EC:1.14.13.95] synonym: "HCO 12alpha-hydroxylase activity" EXACT [EC:1.14.13.95] synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.95] xref: EC:1.14.13.95 xref: GO:0033778 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005267 name: 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + NADPH + H+ + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ + H2O." [EC:1.14.13.96] synonym: "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity" EXACT [EC:1.14.13.96] synonym: "5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.96] synonym: "CYP8B1" RELATED [EC:1.14.13.96] synonym: "cytochrome P450 8B1" RELATED [EC:1.14.13.96] synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.96] xref: EC:1.14.13.96 xref: GO:0033779 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005268 name: taurochenodeoxycholate 6alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97] synonym: "CYP3A4" RELATED [EC:1.14.13.97] synonym: "CYP4A21" RELATED [EC:1.14.13.97] synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" EXACT [EC:1.14.13.97] synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" EXACT [EC:1.14.13.97] xref: EC:1.14.13.97 xref: GO:0033780 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005269 name: cholesterol 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.98] synonym: "cholesterol 24-monooxygenase activity" EXACT [EC:1.14.13.98] synonym: "cholesterol 24S-hydroxylase activity" EXACT [EC:1.14.13.98] synonym: "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity" EXACT [EC:1.14.13.98] synonym: "CYP46" RELATED [EC:1.14.13.98] synonym: "CYP46A1" RELATED [EC:1.14.13.98] synonym: "cytochrome P450 46A1" RELATED [EC:1.14.13.98] xref: EC:1.14.13.98 xref: GO:0033781 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005270 name: 24-hydroxycholesterol 7alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 = (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O." [EC:1.14.13.99] synonym: "(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.99] synonym: "24-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.99] synonym: "CYP39A1" RELATED [EC:1.14.13.99] synonym: "CYP39A1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.99] xref: EC:1.14.13.99 xref: GO:0033782 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005271 name: 25-hydroxycholesterol 7alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O." [EC:1.14.13.100] synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.100] synonym: "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.100] synonym: "CYP7B1" RELATED [EC:1.14.13.100] synonym: "CYP7B1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.100] xref: EC:1.14.13.100 xref: GO:0033783 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005272 name: senecionine N-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: senecionine + NADPH + H+ + O2 = senecionine N-oxide + NADP+ + H2O." [EC:1.14.13.101] synonym: "senecionine monooxygenase (N-oxide-forming) activity" EXACT [EC:1.14.13.101] synonym: "senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity" EXACT [EC:1.14.13.101] synonym: "SNO" RELATED [EC:1.14.13.101] xref: EC:1.14.13.101 xref: GO:0033784 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005273 name: heptose 7-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP." [MetaCyc:RXN0-4341] xref: GO:0033785 xref: MetaCyc:RXN0-4341 is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0005274 name: heptose 1-phosphate adenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose." [MetaCyc:RXN0-4342] xref: GO:0033786 xref: MetaCyc:RXN0-4342 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0005275 name: cyanocobalamin reductase (cyanide-eliminating) activity namespace: molecular_function def: "Catalysis of the reaction: cob(I)alamin + cyanide + NADP+ = cyanocob(III)alamin + NADPH + H+." [EC:1.16.1.6] synonym: "cob(I)alamin, cyanide:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.6] synonym: "cyanocobalamin reductase (NADPH, cyanide-eliminating) activity" EXACT [EC:1.16.1.6] synonym: "cyanocobalamin reductase (NADPH; CN-eliminating) activity" EXACT [EC:1.16.1.6] synonym: "cyanocobalamin reductase activity" EXACT [EC:1.16.1.6] synonym: "NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6] synonym: "NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6] xref: EC:1.16.1.6 xref: GO:0033787 is_a: CCO:F0003305 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: CCO:F0005276 name: leucoanthocyanidin reductase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+." [EC:1.17.1.3] synonym: "(2R,3S)-catechin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.17.1.3] synonym: "leucocyanidin reductase activity" EXACT [EC:1.17.1.3] xref: EC:1.17.1.3 xref: GO:0033788 is_a: CCO:F0003308 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: CCO:F0005277 name: phenylacetyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetyl-CoA + H2O + 2 quinone = phenylglyoxylyl-CoA + 2 quinol." [EC:1.17.5.1] synonym: "phenylacetyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.17.5.1] synonym: "phenylacetyl-CoA:quinone oxidoreductase activity" EXACT [EC:1.17.5.1] xref: EC:1.17.5.1 xref: GO:0033789 is_a: CCO:F0005197 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [Term] id: CCO:F0005278 name: hydroxymethylfurfural reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] xref: GO:0033790 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005279 name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor." [EC:1.17.99.3] synonym: "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity" EXACT [EC:1.17.99.3] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity" EXACT [EC:1.17.99.3] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3] synonym: "THC-CoA oxidase activity" EXACT [EC:1.17.99.3] synonym: "THCA-CoA oxidase activity" EXACT [EC:1.17.99.3] synonym: "trihydroxycoprostanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3] xref: EC:1.17.99.3 xref: GO:0033791 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0005280 name: bile-acid 7alpha-dehydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: deoxycholate + FAD + H2O = cholate + FADH2 and lithocholate + FAD + H2O = chenodeoxycholate + FADH2." [EC:1.17.99.5] synonym: "7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5] synonym: "bile acid 7-dehydroxylase activity" EXACT [EC:1.17.99.5] synonym: "cholate 7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5] synonym: "deoxycholate:FAD oxidoreductase (7alpha-dehydroxylating) activity" EXACT [EC:1.17.99.5] synonym: "deoxycholate:NAD+ oxidoreductase activity" EXACT [EC:1.17.99.5] xref: EC:1.17.99.5 xref: GO:0033792 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0005281 name: aureusidin synthase activity namespace: molecular_function def: "Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O." [EC:1.21.3.6] synonym: "2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity" EXACT [EC:1.21.3.6] xref: EC:1.21.3.6 xref: GO:0033793 is_a: CCO:F0006307 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: CCO:F0005282 name: sarcosine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin." [EC:1.21.4.3] synonym: "acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity" EXACT [EC:1.21.4.3] xref: EC:1.21.4.3 xref: GO:0033794 is_a: CCO:F0007826 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: CCO:F0005283 name: betaine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin." [EC:1.21.4.4] synonym: "acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity" EXACT [EC:1.21.4.4] xref: EC:1.21.4.4 xref: GO:0033795 is_a: CCO:F0007826 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: CCO:F0005284 name: sulfur reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduction of elemental sulfur or polysulfide to hydrogen sulfide." [EC:1.97.1.3] synonym: "(donor):sulfur oxidoreductase activity" EXACT [EC:1.97.1.3] synonym: "sulphur reductase activity" EXACT [] xref: EC:1.97.1.3 xref: GO:0033796 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0005285 name: selenate reductase activity namespace: molecular_function def: "Catalysis of the reaction: selenite + H2O + acceptor = selenate + reduced acceptor." [EC:1.97.1.9] synonym: "selenite:reduced acceptor oxidoreductase activity" EXACT [EC:1.97.1.9] xref: EC:1.97.1.9 xref: GO:0033797 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0005286 name: thyroxine 5-deiodinase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2." [EC:1.97.1.11] synonym: "acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity" EXACT [EC:1.97.1.11] synonym: "diiodothyronine 5'-deiodinase activity" BROAD [EC:1.97.1.11] synonym: "iodothyronine 5-deiodinase activity" EXACT [EC:1.97.1.11] synonym: "iodothyronine inner ring monodeiodinase activity" EXACT [EC:1.97.1.11] synonym: "type III iodothyronine deiodinase activity" NARROW [EC:1.97.1.11] xref: EC:1.97.1.11 xref: GO:0033798 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0005287 name: myricetin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + myricetin = 2 S-adenosyl-L-homocysteine + syringetin." [EC:2.1.1.149] synonym: "CrCOMT2" RELATED [EC:2.1.1.149] synonym: "flavonoid 3',5'-O-dimethyltransferase activity" EXACT [EC:2.1.1.149] synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" EXACT [EC:2.1.1.149] xref: EC:2.1.1.149 xref: GO:0033799 is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0005288 name: isoflavone 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone." [EC:2.1.1.150] synonym: "S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.150] xref: EC:2.1.1.150 xref: GO:0033800 is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0005289 name: vitexin 2''-O-rhamnoside 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside." [EC:2.1.1.153] synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" EXACT [EC:2.1.1.153] xref: EC:2.1.1.153 xref: GO:0033801 is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0005290 name: isoliquiritigenin 2'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin." [EC:2.1.1.154] synonym: "chalcone OMT" RELATED [EC:2.1.1.154] synonym: "CHMT" RELATED [EC:2.1.1.154] synonym: "S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity" EXACT [EC:2.1.1.154] xref: EC:2.1.1.154 xref: GO:0033802 is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0005291 name: kaempferol 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + kaempferide." [EC:2.1.1.155] synonym: "F 4'-OMT" RELATED [EC:2.1.1.155] synonym: "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155] synonym: "S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155] xref: EC:2.1.1.155 xref: GO:0033803 is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0005292 name: glycine/sarcosine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reactions: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine and S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.156] synonym: "ApGSMT" RELATED [EC:2.1.1.156] synonym: "glycine sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156] synonym: "glycine-sarcosine methyltransferase activity" EXACT [EC:2.1.1.156] synonym: "GMT" RELATED [EC:2.1.1.156] synonym: "GSMT" RELATED [EC:2.1.1.156] synonym: "S-adenosyl-L-methionine:sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156] xref: EC:2.1.1.156 xref: GO:0033804 is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0005293 name: sarcosine/dimethylglycine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reactions: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine and S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157] synonym: "ApDMT" RELATED [EC:2.1.1.157] synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157] synonym: "sarcosine dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157] synonym: "sarcosine-dimethylglycine methyltransferase activity" EXACT [EC:2.1.1.157] synonym: "SDMT" RELATED [EC:2.1.1.157] xref: EC:2.1.1.157 xref: GO:0033805 is_a: CCO:F0001757 ! N-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0005294 name: fluorothreonine transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine." [EC:2.2.1.8] synonym: "fluoroacetaldehyde:L-threonine aldehydetransferase activity" EXACT [EC:2.2.1.8] xref: EC:2.2.1.8 xref: GO:0033806 is_a: CCO:F0003320 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: CCO:F0005295 name: icosanoyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+." [EC:2.3.1.119] synonym: "acyl-CoA elongase activity" EXACT [EC:2.3.1.119] synonym: "C18-CoA elongase activity" EXACT [EC:2.3.1.119] synonym: "stearoyl-CoA elongase activity" EXACT [EC:2.3.1.119] synonym: "stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity" EXACT [EC:2.3.1.119] xref: EC:2.3.1.119 xref: GO:0033807 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005296 name: 6'-deoxychalcone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O." [EC:2.3.1.170] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity" EXACT [EC:2.3.1.170] xref: EC:2.3.1.170 xref: GO:0033808 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005297 name: anthocyanin 6''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)." [EC:2.3.1.171] synonym: "3MaT" RELATED [EC:2.3.1.171] synonym: "Dv3MaT" RELATED [EC:2.3.1.171] synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171] synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171] xref: EC:2.3.1.171 xref: GO:0033809 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005298 name: anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin." [EC:2.3.1.172] synonym: "malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity" EXACT [EC:2.3.1.172] synonym: "Ss5MaT1" RELATED [EC:2.3.1.172] xref: EC:2.3.1.172 xref: GO:0033810 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005299 name: flavonol-3-O-triglucoside O-coumaroyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]." [EC:2.3.1.173] synonym: "4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity" EXACT [EC:2.3.1.173] xref: EC:2.3.1.173 xref: GO:0033811 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005300 name: 3-oxoadipyl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA." [EC:2.3.1.174] synonym: "succinyl-CoA:acetyl-CoA C-succinyltransferase activity" EXACT [EC:2.3.1.174] xref: EC:2.3.1.174 xref: GO:0033812 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005301 name: deacetylcephalosporin-C acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = CoA + cephalosporin C." [EC:2.3.1.175] synonym: "acetyl coenzyme A:DAC acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:DAC acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:DAC O-acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "cefG" RELATED [EC:2.3.1.175] synonym: "CPC acetylhydrolase activity" EXACT [EC:2.3.1.175] synonym: "DAC acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "DAC-AT" RELATED [EC:2.3.1.175] synonym: "deacetylcephalosporin C acetyltransferase activity" EXACT [EC:2.3.1.175] xref: EC:2.3.1.175 xref: GO:0033813 is_a: CCO:F0003131 ! C-acyltransferase activity [Term] id: CCO:F0005302 name: propanoyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA." [EC:2.3.1.176] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.176] synonym: "peroxisomal thiolase 2 activity" NARROW [EC:2.3.1.176] synonym: "PTE-2" RELATED [EC:2.3.1.176] synonym: "SCP-X" RELATED [EC:2.3.1.176] synonym: "SCPchi" RELATED [EC:2.3.1.176] synonym: "sterol carrier protein-chi" RELATED [EC:2.3.1.176] synonym: "sterol carrier protein-X" RELATED [EC:2.3.1.176] xref: EC:2.3.1.176 xref: GO:0033814 is_a: CCO:F0003131 ! C-acyltransferase activity [Term] id: CCO:F0005303 name: biphenyl synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2." [EC:2.3.1.177] synonym: "BIS" RELATED [EC:2.3.1.177] synonym: "malonyl-CoA:benzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.177] xref: EC:2.3.1.177 xref: GO:0033815 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005304 name: diaminobutyrate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-2,4-diaminobutanoate = CoA + N4-acetyl-L-2,4-diaminobutanoate." [EC:2.3.1.178] synonym: "2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "DAB acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "DABA acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "DABAcT" RELATED [EC:2.3.1.178] synonym: "diaminobutyric acid acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "EctA" RELATED [EC:2.3.1.178] synonym: "L-2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "L-2,4-diaminobutyrate acetyltransferase activity" EXACT [EC:2.3.1.178] xref: EC:2.3.1.178 xref: GO:0033816 is_a: CCO:F0003130 ! acetyltransferase activity [Term] id: CCO:F0005305 name: beta-ketoacyl-acyl-carrier-protein synthase II activity namespace: molecular_function def: "Catalysis of the reaction: (Z)-hexadec-11-enoyl-acyl-carrier-protein + malonyl-acyl-carrier-protein = (Z)-3-oxooctadec-13-enoyl-acyl-carrier-protein + CO2 + acyl-carrier-protein." [EC:2.3.1.179] synonym: "(Z)-hexadec-11-enoyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.179] synonym: "3-oxoacyl-acyl carrier protein synthase I activity" EXACT [EC:2.3.1.179] synonym: "beta-ketoacyl-ACP synthase II activity" EXACT [EC:2.3.1.179] synonym: "FabF" RELATED [EC:2.3.1.179] synonym: "KAS II" RELATED [EC:2.3.1.179] synonym: "KASII" RELATED [EC:2.3.1.179] xref: EC:2.3.1.179 xref: GO:0033817 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005306 name: beta-ketoacyl-acyl-carrier-protein synthase III activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + malonyl-acyl-carrier-protein = acetoacyl-acyl-carrier-protein + CoA + CO2." [EC:2.3.1.180] synonym: "3-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180] synonym: "3-oxoacyl:ACP synthase III activity" EXACT [EC:2.3.1.180] synonym: "acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity" EXACT [EC:2.3.1.180] synonym: "beta-ketoacyl (acyl carrier protein) synthase III activity" EXACT [EC:2.3.1.180] synonym: "beta-ketoacyl-ACP synthase III activity" EXACT [EC:2.3.1.180] synonym: "beta-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180] synonym: "FabH" RELATED [EC:2.3.1.180] synonym: "KAS III" RELATED [EC:2.3.1.180] synonym: "KASIII" RELATED [EC:2.3.1.180] xref: EC:2.3.1.180 xref: GO:0033818 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005307 name: lipoyl(octanoyl) transferase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-acyl-carrier-protein + protein = protein N6-(octanoyl)lysine + acyl carrier protein." [EC:2.3.1.181] synonym: "LipB" RELATED [EC:2.3.1.181] synonym: "lipoate/octanoate transferase activity" EXACT [EC:2.3.1.181] synonym: "lipoyl (octanoyl)-acyl carrier protein:protein transferase activity" EXACT [EC:2.3.1.181] synonym: "lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity" EXACT [EC:2.3.1.181] synonym: "octanoyl-acyl carrier protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] synonym: "octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] synonym: "octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] xref: EC:2.3.1.181 xref: GO:0033819 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005308 name: DNA alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Transfers an alpha-D-glucosyl residue from UDP-glucose to an hydroxymethylcytosine residue in DNA." [EC:2.4.1.26] synonym: "T2-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] synonym: "T4-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] synonym: "T6-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] synonym: "UDP-glucose:DNA alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.26] synonym: "UDPglucose-DNA alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26] synonym: "uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26] xref: EC:2.4.1.26 xref: GO:0033820 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005309 name: DNA beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Transfers a beta-D-glucosyl residue from UDP-glucose to an hydroxymethylcytosine residue in DNA." [EC:2.4.1.27] synonym: "T4 phage beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "T4-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27] synonym: "T4-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27] synonym: "UDP glucose-DNA beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "UDP-glucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "UDPglucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] xref: EC:2.4.1.27 xref: GO:0033821 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005310 name: glucosyl-DNA beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Transfers a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA." [EC:2.4.1.28] synonym: "T6-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28] synonym: "T6-glucosyl-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28] synonym: "UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28] synonym: "UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28] synonym: "uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.28] xref: EC:2.4.1.28 xref: GO:0033822 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005311 name: procollagen glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen." [EC:2.4.1.66] synonym: "collagen glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "collagen hydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "galactosylhydroxylysine glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "galactosylhydroxylysine-glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "galactosylhydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "UDP-glucose-collagenglucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" EXACT [EC:2.4.1.66] xref: EC:2.4.1.66 xref: GO:0033823 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005312 name: alternansucrase activity namespace: molecular_function def: "Catalysis of the reaction: Transfers alternately an alpha-D-glucosyl residue from sucrose to the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages." [EC:2.4.1.140] synonym: "sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.140] synonym: "sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.140] synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity" BROAD [EC:2.4.1.140] xref: EC:2.4.1.140 xref: GO:0033824 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005313 name: oligosaccharide 4-alpha-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Transfers the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides." [EC:2.4.1.161] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.161] synonym: "1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.161] synonym: "amylase III activity" EXACT [EC:2.4.1.161] xref: EC:2.4.1.161 xref: GO:0033825 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005314 name: xyloglucan 4-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Transfers a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage." [EC:2.4.1.168] synonym: "UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "xyloglucan 4beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "xyloglucan glucosyltransferase activity" EXACT [EC:2.4.1.168] xref: EC:2.4.1.168 xref: GO:0033826 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005315 name: high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum." [EC:2.4.1.197] synonym: "acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] synonym: "UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] synonym: "UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] synonym: "uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] xref: EC:2.4.1.197 xref: GO:0033827 is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0005316 name: glucosylglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-glucose + sn-glycerol 3-phosphate = 2-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP." [EC:2.4.1.213] synonym: "ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213] synonym: "ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213] synonym: "GG-phosphate synthase activity" EXACT [EC:2.4.1.213] synonym: "GGPS" RELATED [EC:2.4.1.213] synonym: "glucosyl-glycerol-phosphate synthase activity" EXACT [EC:2.4.1.213] xref: EC:2.4.1.213 xref: GO:0033828 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005317 name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222] synonym: "O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.222] synonym: "UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.222] xref: EC:2.4.1.222 xref: GO:0033829 is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0005318 name: Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline." [EC:2.4.1.229] synonym: "Skp1-HyPro GlcNAc-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229] xref: EC:2.4.1.229 xref: GO:0033830 is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0005319 name: kojibiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-alpha-D-glucosyl-D-glucose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.230] synonym: "2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.230] xref: EC:2.4.1.230 xref: GO:0033831 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005320 name: alpha,alpha-trehalose phosphorylase (configuration-retaining) activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.231] synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.231] synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231] xref: GO:0033832 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005321 name: hydroxymethylfurfural reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] xref: GO:0033833 is_a: CCO:F0005278 ! hydroxymethylfurfural reductase activity [Term] id: CCO:F0005322 name: kaempferol 3-O-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside." [EC:2.4.1.234] synonym: "F3GalTase activity" EXACT [EC:2.4.1.234] synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.234] xref: EC:2.4.1.234 xref: GO:0033834 is_a: CCO:F0001853 ! galactosyltransferase activity [Term] id: CCO:F0005323 name: flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]." [EC:2.4.1.236] synonym: "1->2 UDP-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] synonym: "UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] synonym: "UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] xref: EC:2.4.1.236 xref: GO:0033835 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0005324 name: flavonol 7-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside." [EC:2.4.1.237] synonym: "UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.237] synonym: "UDP-glucose:flavonol 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.237] xref: EC:2.4.1.237 xref: GO:0033836 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005325 name: anthocyanin 3'-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside." [EC:2.4.1.238] synonym: "3'GT" RELATED [EC:2.4.1.238] synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.238] synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" EXACT [EC:2.4.1.238] xref: EC:2.4.1.238 xref: GO:0033837 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005326 name: flavonol-3-O-glucoside glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.239] synonym: "UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.239] xref: EC:2.4.1.239 xref: GO:0033838 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005327 name: flavonol-3-O-glycoside glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.240] synonym: "UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.240] xref: EC:2.4.1.240 xref: GO:0033839 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005328 name: NDP-glucose-starch glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1." [EC:2.4.1.242] synonym: "GBSS" RELATED [EC:2.4.1.242] synonym: "GBSSI" RELATED [EC:2.4.1.242] synonym: "GBSSII" RELATED [EC:2.4.1.242] synonym: "granule-bound starch synthase activity" EXACT [EC:2.4.1.242] synonym: "granule-bound starch synthase I activity" EXACT [EC:2.4.1.242] synonym: "granule-bound starch synthase II activity" EXACT [EC:2.4.1.242] synonym: "NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.242] synonym: "NDPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242] synonym: "starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242] synonym: "starch synthase II activity" EXACT [EC:2.4.1.242] synonym: "waxy protein" RELATED [EC:2.4.1.242] xref: EC:2.4.1.242 xref: GO:0033840 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005329 name: 6G-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)." [EC:2.4.1.243] synonym: "1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity" EXACT [EC:2.4.1.243] synonym: "6G-FFT" RELATED [EC:2.4.1.243] synonym: "6G-fructotransferase activity" EXACT [EC:2.4.1.243] synonym: "6G-FT" RELATED [EC:2.4.1.243] synonym: "fructan:fructan 6G-fructosyltransferase activity" EXACT [EC:2.4.1.243] xref: EC:2.4.1.243 xref: GO:0033841 is_a: CCO:F0008006 ! fructosyltransferase activity [Term] id: CCO:F0005330 name: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244] synonym: "beta1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244] synonym: "beta1,4-N-acetylgalactosaminyltransferase III activity" EXACT [EC:2.4.1.244] synonym: "beta1,4-N-acetylgalactosaminyltransferase IV activity" EXACT [EC:2.4.1.244] synonym: "beta4GalNAc-T3" RELATED [EC:2.4.1.244] synonym: "beta4GalNAc-T4" RELATED [EC:2.4.1.244] synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244] xref: EC:2.4.1.244 xref: GO:0033842 is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0005331 name: xyloglucan 6-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Transfers an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage." [EC:2.4.2.39] synonym: "UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39] synonym: "uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity" EXACT [EC:2.4.2.39] synonym: "xyloglucan 6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39] xref: EC:2.4.2.39 xref: GO:0033843 is_a: CCO:F0005645 ! xylosyltransferase activity [Term] id: CCO:F0005332 name: galactose-6-sulfurylase activity namespace: molecular_function def: "Catalysis of the reaction: Eliminates sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues." [EC:2.5.1.5] synonym: "D-galactose-6-sulfate:alkyltransferase (cyclizing) activity" EXACT [EC:2.5.1.5] synonym: "galactose 6-sulfatase activity" EXACT [EC:2.5.1.5] synonym: "galactose-6-sulfatase activity" EXACT [EC:2.5.1.5] synonym: "porphyran sulfatase activity" EXACT [EC:2.5.1.5] xref: EC:2.5.1.5 xref: GO:0033844 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005333 name: hydroxymethylfurfural reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] xref: GO:0033845 is_a: CCO:F0005278 ! hydroxymethylfurfural reductase activity [Term] id: CCO:F0005334 name: adenosyl-fluoride synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine." [EC:2.5.1.63] synonym: "fluorinase activity" EXACT [EC:2.5.1.63] synonym: "S-adenosyl-L-methionine:fluoride adenosyltransferase activity" EXACT [EC:2.5.1.63] xref: EC:2.5.1.63 xref: GO:0033846 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005335 name: O-phosphoserine sulfhydrylase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate." [EC:2.5.1.65] synonym: "O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.65] synonym: "O-phosphoserine(thiol)-lyase activity" EXACT [EC:2.5.1.65] xref: EC:2.5.1.65 xref: GO:0033847 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005336 name: N2-(2-carboxyethyl)arginine synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N2-(2-carboxyethyl)-L-arginine + phosphate." [EC:2.5.1.66] synonym: "CEA synthetase activity" EXACT [EC:2.5.1.66] synonym: "CEAS" RELATED [EC:2.5.1.66] synonym: "glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66] synonym: "glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66] synonym: "N2-(2-carboxyethyl)arginine synthetase activity" EXACT [EC:2.5.1.66] xref: EC:2.5.1.66 xref: GO:0033848 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005337 name: chrysanthemyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + chrysanthemyl diphosphate." [EC:2.5.1.67] synonym: "CPPase activity" EXACT [EC:2.5.1.67] synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity" EXACT [EC:2.5.1.67] xref: EC:2.5.1.67 xref: GO:0033849 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005338 name: Z-farnesyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate." [EC:2.5.1.68] synonym: "(Z)-farnesyl diphosphate synthase activity" EXACT [EC:2.5.1.68] synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity" EXACT [EC:2.5.1.68] xref: EC:2.5.1.68 xref: GO:0033850 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005339 name: lavandulyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate." [EC:2.5.1.69] synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity" EXACT [EC:2.5.1.69] synonym: "FDS-5" RELATED [EC:2.5.1.69] xref: EC:2.5.1.69 xref: GO:0033851 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005340 name: thyroid-hormone transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate." [EC:2.6.1.26] synonym: "3,5-dinitrotyrosine aminotransferase activity" EXACT [EC:2.6.1.26] synonym: "3,5-dinitrotyrosine transaminase activity" EXACT [EC:2.6.1.26] synonym: "L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.26] synonym: "thyroid hormone aminotransferase activity" EXACT [EC:2.6.1.26] synonym: "thyroid-hormone aminotransferase activity" EXACT [EC:2.6.1.26] xref: EC:2.6.1.26 xref: GO:0033852 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0005341 name: aspartate-prephenate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate." [EC:2.6.1.78] synonym: "L-arogenate:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.78] synonym: "L-aspartate:prephenate aminotransferase activity" EXACT [EC:2.6.1.78] synonym: "PAT" RELATED [EC:2.6.1.78] synonym: "prephenate aspartate aminotransferase activity" EXACT [EC:2.6.1.78] synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.78] xref: EC:2.6.1.78 xref: GO:0033853 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0005342 name: glutamate-prephenate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + 2-oxoglutarate = prephenate + L-glutamate." [EC:2.6.1.79] synonym: "L-arogenate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.79] synonym: "L-glutamate:prephenate aminotransferase activity" EXACT [EC:2.6.1.79] synonym: "PAT" RELATED [EC:2.6.1.79] synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.79] xref: EC:2.6.1.79 xref: GO:0033854 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0005343 name: nicotianamine aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate." [EC:2.6.1.80] synonym: "NAAT" RELATED [EC:2.6.1.80] synonym: "NAAT-I" RELATED [EC:2.6.1.80] synonym: "NAAT-II" RELATED [EC:2.6.1.80] synonym: "NAAT-III" RELATED [EC:2.6.1.80] synonym: "nicotianamine transaminase activity" EXACT [EC:2.6.1.80] synonym: "nicotianamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.80] xref: EC:2.6.1.80 xref: GO:0033855 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0005344 name: pyridoxine 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O." [EC:2.6.99.2] synonym: "1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity" EXACT [EC:2.6.99.2] synonym: "PdxJ" RELATED [EC:2.6.99.2] synonym: "PNP synthase activity" EXACT [EC:2.6.99.2] synonym: "pyridoxine 5-phosphate phospho lyase activity" EXACT [EC:2.6.99.2] xref: EC:2.6.99.2 xref: GO:0033856 is_a: CCO:F0003342 ! transferase activity, transferring nitrogenous groups [Term] id: CCO:F0005345 name: diphosphoinositol-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.24] synonym: "ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.24] synonym: "PP-InsP5 kinase activity" EXACT [EC:2.7.4.24] synonym: "PP-IP5 kinase activity" EXACT [EC:2.7.4.24] synonym: "PPIP5K" RELATED [EC:2.7.4.24] synonym: "PPIP5K1" RELATED [EC:2.7.4.24] synonym: "PPIP5K2" RELATED [EC:2.7.4.24] synonym: "VIP1" NARROW [EC:2.7.4.24] synonym: "VIP2" NARROW [EC:2.7.4.24] xref: EC:2.7.4.24 xref: GO:0033857 is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0005346 name: N-acetylgalactosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157] synonym: "ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity" EXACT [EC:2.7.1.157] synonym: "GALK2" RELATED [EC:2.7.1.157] synonym: "GalNAc kinase activity" EXACT [EC:2.7.1.157] synonym: "GK2" RELATED [EC:2.7.1.157] synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" EXACT [EC:2.7.1.157] xref: EC:2.7.1.157 xref: GO:0033858 is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0005347 name: UMP kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UMP = ADP + UDP." [EC:2.7.4.22] synonym: "ATP:UMP phosphotransferase activity" EXACT [EC:2.7.4.22] synonym: "PyrH" RELATED [EC:2.7.4.22] synonym: "SmbA" RELATED [EC:2.7.4.22] synonym: "UMP-kinase activity" EXACT [EC:2.7.4.22] synonym: "UMPK" RELATED [EC:2.7.4.22] synonym: "uridine monophosphate kinase activity" EXACT [EC:2.7.4.22] xref: EC:2.7.4.22 xref: GO:0033862 is_a: CCO:F0002370 ! uridylate kinase activity [Term] id: CCO:F0005348 name: ribose 1,5-bisphosphate phosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.7.4.23] synonym: "ATP:ribose-1,5-bisphosphate phosphotransferase activity" EXACT [EC:2.7.4.23] synonym: "PhnN" RELATED [EC:2.7.4.23] synonym: "ribose 1,5-bisphosphokinase activity" EXACT [EC:2.7.4.23] xref: EC:2.7.4.23 xref: GO:0033863 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0005349 name: Fas-activated serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8] synonym: "ATP:Fas-activated serine/threonine protein phosphotransferase activity" EXACT [EC:2.7.11.8] synonym: "FAST" RELATED [EC:2.7.11.8] synonym: "FASTK" RELATED [EC:2.7.11.8] synonym: "STK10" RELATED [EC:2.7.11.8] xref: EC:2.7.11.8 xref: GO:0033867 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0005350 name: Goodpasture-antigen-binding protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9] synonym: "ATP:Goodpasture antigen-binding protein phosphotransferase activity" EXACT [EC:2.7.11.9] synonym: "Goodpasture antigen-binding protein kinase activity" EXACT [EC:2.7.11.9] synonym: "GPBP kinase activity" EXACT [EC:2.7.11.9] synonym: "GPBPK" RELATED [EC:2.7.11.9] synonym: "STK11" RELATED [EC:2.7.11.9] xref: EC:2.7.11.9 xref: GO:0033868 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0005351 name: thiol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate." [EC:2.8.2.16] synonym: "3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity" EXACT [EC:2.8.2.16] synonym: "adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity" EXACT [EC:2.8.2.16] synonym: "PAPS sulfotransferase activity" BROAD [EC:2.8.2.16] xref: EC:2.8.2.16 xref: GO:0033870 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0005354 name: petromyzonol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol = adenosine 3',5'-bisphosphate + 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate." [EC:2.8.2.31] synonym: "3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity" EXACT [EC:2.8.2.31] synonym: "PZ-SULT" RELATED [EC:2.8.2.31] xref: EC:2.8.2.31 xref: GO:0033873 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0005355 name: scymnol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + 5beta-scymnol = adenosine 3',5'-bisphosphate + 5beta-scymnol sulfate." [EC:2.8.2.32] xref: EC:2.8.2.32 xref: GO:0033874 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0005356 name: glycochenodeoxycholate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate." [EC:2.8.2.34] synonym: "3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity" EXACT [EC:2.8.2.34] synonym: "BAST" RELATED [EC:2.8.2.34] synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" BROAD [EC:2.8.2.34] synonym: "bile acid:PAPS:sulfotransferase activity" EXACT [EC:2.8.2.34] xref: EC:2.8.2.34 xref: GO:0033876 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0005357 name: succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA." [EC:2.8.3.15] synonym: "benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15] synonym: "succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15] xref: EC:2.8.3.15 xref: GO:0033877 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0005358 name: hormone-sensitive lipase activity namespace: molecular_function def: "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate, triacylglycerol + H2O = diacylglycerol + a carboxylate, and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79] synonym: "diacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.79] synonym: "HSL" RELATED [EC:3.1.1.79] xref: EC:3.1.1.79 xref: GO:0033878 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0005359 name: acetylajmaline esterase activity namespace: molecular_function def: "Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate and 17-O-acetylnorajmaline + H2O = norajmaline + acetate." [EC:3.1.1.80] synonym: "17-O-acetylajmaline O-acetylhydrolase activity" EXACT [EC:3.1.1.80] synonym: "2beta(R)-17-O-acetylajmalan:acetylesterase activity" EXACT [EC:3.1.1.80] synonym: "AAE" RELATED [EC:3.1.1.80] synonym: "acetylajmalan esterase activity" EXACT [EC:3.1.1.80] xref: EC:3.1.1.80 xref: GO:0033879 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0005360 name: phenylacetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA." [EC:3.1.2.25] synonym: "phenylglyoxylyl-CoA hydrolase activity" EXACT [EC:3.1.2.25] xref: EC:3.1.2.25 xref: GO:0033880 is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0005361 name: bile-acid-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deoxycholoyl-CoA + H2O = CoA + deoxycholate." [EC:3.1.2.26] synonym: "bile acid-coenzyme A hydrolase activity" EXACT [EC:3.1.2.26] synonym: "deoxycholoyl-CoA hydrolase activity" EXACT [EC:3.1.2.26] xref: EC:3.1.2.26 xref: GO:0033881 is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0005362 name: choloyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA." [EC:3.1.2.27] synonym: "chenodeoxycholoyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27] synonym: "choloyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27] synonym: "peroxisomal acyl-CoA thioesterase 2 activity" NARROW [EC:3.1.2.27] synonym: "PTE-2" RELATED [EC:3.1.2.27] xref: EC:3.1.2.27 xref: GO:0033882 is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0005363 name: pyridoxal phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74] synonym: "PLP phosphatase activity" EXACT [EC:3.1.3.74] synonym: "PNP phosphatase activity" EXACT [EC:3.1.3.74] synonym: "pyridoxal-5'-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.74] synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74] synonym: "vitamine B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74] xref: EC:3.1.3.74 xref: GO:0033883 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0005364 name: phosphoethanolamine/phosphocholine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate and phosphocholine + H2O = choline + phosphate." [EC:3.1.3.75] synonym: "3X11A" RELATED [EC:3.1.3.75] synonym: "PHOSPHO1" RELATED [EC:3.1.3.75] synonym: "phosphoethanolamine phosphohydrolase activity" EXACT [EC:3.1.3.75] xref: EC:3.1.3.75 xref: GO:0033884 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0005365 name: lipid-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate." [EC:3.1.3.76] synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity" EXACT [EC:3.1.3.76] synonym: "dihydroxy fatty acid phosphatase activity" EXACT [EC:3.1.3.76] synonym: "hydroxy fatty acid phosphatase activity" EXACT [EC:3.1.3.76] synonym: "hydroxy lipid phosphatase activity" EXACT [EC:3.1.3.76] synonym: "sEH" RELATED [EC:3.1.3.76] synonym: "soluble epoxide hydrolase activity" RELATED [EC:3.1.3.76] xref: EC:3.1.3.76 xref: GO:0033885 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0005366 name: cellulose-polysulfatase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin." [EC:3.1.6.7] synonym: "cellulose-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.7] xref: EC:3.1.6.7 xref: GO:0033886 is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0005367 name: chondro-4-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate." [EC:3.1.6.9] synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.9] xref: EC:3.1.6.9 xref: GO:0033887 is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0005368 name: chondro-6-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate." [EC:3.1.6.10] synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.10] xref: EC:3.1.6.10 xref: GO:0033888 is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0005369 name: N-sulfoglucosamine-3-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin." [EC:3.1.6.15] synonym: "chondroitinsulfatase activity" BROAD [EC:3.1.6.15] synonym: "N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity" EXACT [EC:3.1.6.15] xref: EC:3.1.6.15 xref: GO:0033889 is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0005370 name: ribonuclease D activity namespace: molecular_function def: "Catalysis of the reaction: exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides." [EC:3.1.13.5] synonym: "RNase D activity" EXACT [EC:3.1.13.5] xref: EC:3.1.13.5 xref: GO:0033890 is_a: CCO:F0003454 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005371 name: CC-preferring endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the reaction: endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC." [EC:3.1.21.6] synonym: "5'-CC-3'-preferring endodeoxyribonuclease activity" EXACT [EC:3.1.21.6] synonym: "Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity" EXACT [EC:3.1.21.6] synonym: "Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity" EXACT [EC:3.1.21.6] synonym: "Streptomyces glaucescens exocytoplasmic endonuclease activity" EXACT [EC:3.1.21.6] xref: EC:3.1.21.6 xref: GO:0033891 is_a: CCO:F0003446 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005372 name: deoxyribonuclease (pyrimidine dimer) activity namespace: molecular_function def: "Catalysis of the reaction: endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.1] synonym: "bacteriophage T4 endodeoxyribonuclease V activity" EXACT [EC:3.1.25.1] synonym: "endodeoxyribonuclease (pyrimidine dimer) activity" EXACT [EC:3.1.25.1] synonym: "T4 endonuclease V activity" EXACT [EC:3.1.25.1] xref: EC:3.1.25.1 xref: GO:0033892 is_a: CCO:F0003448 ! site-specific endodeoxyribonuclease activity, specific for altered base [Term] id: CCO:F0005373 name: ribonuclease IV activity namespace: molecular_function def: "Catalysis of the reaction: endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.6] synonym: "endoribonuclease IV activity" EXACT [EC:3.1.26.6] xref: EC:3.1.26.6 xref: GO:0033893 is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005374 name: ribonuclease P4 activity namespace: molecular_function def: "Catalysis of the reaction: endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor." [EC:3.1.26.7] xref: EC:3.1.26.7 xref: GO:0033894 is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005375 name: ribonuclease [poly-(U)-specific] activity namespace: molecular_function def: "Catalysis of the reaction: endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.9] synonym: "ribonuclease (uracil-specific) activity" EXACT [EC:3.1.26.9] synonym: "uracil-specific endoribonuclease activity" EXACT [EC:3.1.26.9] synonym: "uracil-specific RNase activity" EXACT [EC:3.1.26.9] xref: EC:3.1.26.9 xref: GO:0033895 is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005376 name: ribonuclease IX activity namespace: molecular_function def: "Catalysis of the reaction: endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.10] synonym: "poly(U)- and poly(C)-specific endoribonuclease activity" EXACT [EC:3.1.26.10] xref: EC:3.1.26.10 xref: GO:0033896 is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005377 name: ribonuclease T2 activity namespace: molecular_function def: "Catalysis of the reaction: two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.1] synonym: "acid ribonuclease activity" EXACT [EC:3.1.27.1] synonym: "acid RNase activity" EXACT [EC:3.1.27.1] synonym: "base-non-specific ribonuclease activity" EXACT [EC:3.1.27.1] synonym: "Escherichia coli ribonuclease I' ribonuclease PP2 activity" EXACT [EC:3.1.27.1] synonym: "Escherichia coli ribonuclease II activity" EXACT [EC:3.1.27.1] synonym: "non-base specific ribonuclease activity" EXACT [EC:3.1.27.1] synonym: "nonbase-specific RNase activity" EXACT [EC:3.1.27.1] synonym: "nonspecific RNase activity" EXACT [EC:3.1.27.1] synonym: "ribonnuclease (non-base specific) activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease (non-base specific) activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease II activity" BROAD [EC:3.1.27.1] synonym: "ribonuclease M activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease N2 activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease PP3 activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease U4 activity" EXACT [EC:3.1.27.1] synonym: "ribonucleate 3'-oligonucleotide hydrolase activity" EXACT [EC:3.1.27.1] synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.1] synonym: "RNAase CL activity" EXACT [EC:3.1.27.1] synonym: "RNase (non-base specific) activity" EXACT [EC:3.1.27.1] synonym: "RNase II activity" BROAD [EC:3.1.27.1] synonym: "RNase M activity" EXACT [EC:3.1.27.1] synonym: "RNase Ms activity" EXACT [EC:3.1.27.1] synonym: "RNase T2 activity" EXACT [EC:3.1.27.1] xref: EC:3.1.27.1 xref: GO:0033897 is_a: CCO:F0003450 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0005378 name: Bacillus subtilis ribonuclease activity namespace: molecular_function def: "Catalysis of the reaction: endonucleolytic cleavage to 2',3'-cyclic nucleotides." [EC:3.1.27.2] synonym: "proteus mirabilis RNase activity" EXACT [EC:3.1.27.2] synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.2] xref: EC:3.1.27.2 xref: GO:0033898 is_a: CCO:F0003450 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0005379 name: ribonuclease U2 activity namespace: molecular_function def: "Catalysis of the reaction: two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.4] synonym: "pleospora RNase activity" EXACT [EC:3.1.27.4] synonym: "purine specific endoribonuclease activity" EXACT [EC:3.1.27.4] synonym: "purine-specific ribonuclease activity" EXACT [EC:3.1.27.4] synonym: "purine-specific RNase activity" EXACT [EC:3.1.27.4] synonym: "ribonuclease (purine) activity" EXACT [EC:3.1.27.4] synonym: "ribonuclease U3 activity" EXACT [EC:3.1.27.4] synonym: "RNase U3 activity" EXACT [EC:3.1.27.4] synonym: "trichoderma koningi RNase III activity" EXACT [EC:3.1.27.4] xref: EC:3.1.27.4 xref: GO:0033899 is_a: CCO:F0003450 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0005380 name: ribonuclease F activity namespace: molecular_function def: "Catalysis of the reaction: endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups." [EC:3.1.27.7] synonym: "ribonuclease F (E. coli) activity" EXACT [EC:3.1.27.7] synonym: "RNase F activity" EXACT [EC:3.1.27.7] xref: EC:3.1.27.7 xref: GO:0033900 is_a: CCO:F0003450 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0005381 name: ribonuclease V activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP." [EC:3.1.27.8] synonym: "endoribonuclease V activity" EXACT [EC:3.1.27.8] xref: EC:3.1.27.8 xref: GO:0033901 is_a: CCO:F0003450 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0005382 name: rRNA endonuclease activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes." [EC:3.1.27.10] synonym: "alpha-sarcin" RELATED [EC:3.1.27.10] xref: EC:3.1.27.10 xref: GO:0033902 is_a: CCO:F0003450 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: CCO:F0005383 name: endo-1,3(4)-beta-glucanase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6] synonym: "1,3-(1,3;1,4)-beta-D-glucan 3(4)-glucanohydrolase activity" EXACT [EC:3.2.1.6] synonym: "beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6] synonym: "beta-1,3-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-1,3-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.6] synonym: "endo-1,3-beta-D-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-1,3-beta-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-beta-(1-3)-D-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-beta-(1->3)-D-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-beta-1,3(4)-glucanase activity" EXACT [EC:3.2.1.6] synonym: "endo-beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6] synonym: "endo-beta-1,3-glucanase IV activity" EXACT [EC:3.2.1.6] synonym: "laminaranase activity" BROAD [EC:3.2.1.6] synonym: "laminarinase activity" BROAD [EC:3.2.1.6] xref: EC:3.2.1.6 xref: GO:0033903 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005384 name: dextranase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran." [EC:3.2.1.11] synonym: "1,6-alpha-D-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.11] synonym: "alpha-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11] synonym: "alpha-D-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11] synonym: "dextran hydrolase activity" EXACT [EC:3.2.1.11] synonym: "dextranase DL 2 activity" NARROW [EC:3.2.1.11] synonym: "DL 2" RELATED [EC:3.2.1.11] synonym: "endo-dextranase activity" EXACT [EC:3.2.1.11] synonym: "endodextranase activity" EXACT [EC:3.2.1.11] xref: EC:3.2.1.11 xref: GO:0033904 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005385 name: xylan endo-1,3-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the reaction: random hydrolysis of 1,3-beta-D-glycosidic linkages in 1,3-beta-D-xylans." [EC:3.2.1.32] synonym: "1,3-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.32] synonym: "1,3-beta-xylanase activity" EXACT [EC:3.2.1.32] synonym: "1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "beta-1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "endo-1,3-beta-xylanase activity" EXACT [EC:3.2.1.32] synonym: "endo-1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "endo-beta-1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "xylanase activity" BROAD [EC:3.2.1.32] xref: EC:3.2.1.32 xref: GO:0033905 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005386 name: hyaluronoglucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate." [EC:3.2.1.36] synonym: "glucuronoglucosaminoglycan hyaluronate lyase activity" EXACT [EC:3.2.1.36] synonym: "hyaluronate 3-glycanohydrolase activity" EXACT [EC:3.2.1.36] synonym: "hyaluronidase activity" BROAD [EC:3.2.1.36] synonym: "orgelase activity" EXACT [EC:3.2.1.36] xref: EC:3.2.1.36 xref: GO:0033906 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005387 name: beta-D-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides." [EC:3.2.1.38] synonym: "beta-D-fucoside fucohydrolase activity" EXACT [EC:3.2.1.38] synonym: "beta-fucosidase activity" EXACT [EC:3.2.1.38] xref: EC:3.2.1.38 xref: GO:0033907 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005388 name: beta-L-rhamnosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides." [EC:3.2.1.43] synonym: "beta-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.43] xref: EC:3.2.1.43 xref: GO:0033908 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005389 name: fucoidanase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate." [EC:3.2.1.44] synonym: "poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity" EXACT [EC:3.2.1.44] xref: EC:3.2.1.44 xref: GO:0033909 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005390 name: glucan 1,4-alpha-maltotetraohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends." [EC:3.2.1.60] synonym: "1,4-alpha-D-glucan maltotetraohydrolase activity" EXACT [EC:3.2.1.60] synonym: "exo-maltotetraohydrolase activity" EXACT [EC:3.2.1.60] synonym: "G4-amylase activity" EXACT [EC:3.2.1.60] synonym: "glucan 1,4-alpha-maltotetrahydrolase activity" EXACT [EC:3.2.1.60] synonym: "maltotetraose-forming amylase activity" EXACT [EC:3.2.1.60] xref: EC:3.2.1.60 xref: GO:0033910 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005391 name: mycodextranase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds." [EC:3.2.1.61] synonym: "1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.61] xref: EC:3.2.1.61 xref: GO:0033911 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005392 name: 2,6-beta-fructan 6-levanbiohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 2,6-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain." [EC:3.2.1.64] synonym: "2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity" EXACT [EC:3.2.1.64] synonym: "2,6-beta-D-fructan 6-levanbiohydrolase activity" EXACT [EC:3.2.1.64] synonym: "2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity" EXACT [EC:3.2.1.64] synonym: "beta-2,6-fructan-6-levanbiohydrolase activity" EXACT [EC:3.2.1.64] synonym: "levanbiose-producing levanase activity" EXACT [EC:3.2.1.64] xref: EC:3.2.1.64 xref: GO:0033912 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005393 name: glucan endo-1,2-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: random hydrolysis of 1,2-glucosidic linkages in 1,2-beta-D-glucans." [EC:3.2.1.71] synonym: "1,2-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.71] synonym: "beta-D-1,2-glucanase activity" EXACT [EC:3.2.1.71] synonym: "endo-(1->2)-beta-D-glucanase activity" EXACT [EC:3.2.1.71] synonym: "endo-1,2-beta-glucanase activity" EXACT [EC:3.2.1.71] xref: EC:3.2.1.71 xref: GO:0033913 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005394 name: xylan 1,3-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of successive xylose residues from the non-reducing termini of 1,3-beta-D-xylans." [EC:3.2.1.72] synonym: "1,3-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.72] synonym: "1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72] synonym: "beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72] synonym: "exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72] synonym: "exo-beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72] xref: EC:3.2.1.72 xref: GO:0033914 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005395 name: mannan 1,2-(1,3)-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,2- and 1,3-linkages in yeast mannan, releasing mannose." [EC:3.2.1.77] synonym: "1,2-1,3-alpha-D-mannan mannohydrolase activity" EXACT [EC:3.2.1.77] synonym: "exo-1,2-1,3-alpha-mannosidase activity" EXACT [EC:3.2.1.77] xref: EC:3.2.1.77 xref: GO:0033915 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005396 name: beta-agarase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product." [EC:3.2.1.81] synonym: "AgaA" RELATED [EC:3.2.1.81] synonym: "AgaB" RELATED [EC:3.2.1.81] synonym: "agarase activity" BROAD [EC:3.2.1.81] synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.81] synonym: "agarose 4-glycanohydrolase activity" EXACT [EC:3.2.1.81] xref: EC:3.2.1.81 xref: GO:0033916 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005397 name: exo-poly-alpha-galacturonosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate." [EC:3.2.1.82] synonym: "exopolygalacturanosidase activity" EXACT [EC:3.2.1.82] synonym: "exopolygalacturonosidase activity" EXACT [EC:3.2.1.82] xref: EC:3.2.1.82 xref: GO:0033917 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005398 name: kappa-carrageenase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans." [EC:3.2.1.83] synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity" EXACT [EC:3.2.1.83] synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase activity" EXACT [EC:3.2.1.83] xref: EC:3.2.1.83 xref: GO:0033918 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005399 name: glucan 1,3-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of terminal 1,3-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84] synonym: "1,3-alpha-D-glucan 3-glucohydrolase activity" EXACT [EC:3.2.1.84] synonym: "exo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.84] synonym: "glucosidase II activity" EXACT [EC:3.2.1.84] xref: EC:3.2.1.84 xref: GO:0033919 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005400 name: 6-phospho-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol." [EC:3.2.1.85] synonym: "6-phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85] synonym: "6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity" EXACT [EC:3.2.1.85] synonym: "beta-D-phosphogalactoside galactohydrolase activity" EXACT [EC:3.2.1.85] synonym: "phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85] synonym: "phospho-beta-galactosidase activity" EXACT [EC:3.2.1.85] xref: EC:3.2.1.85 xref: GO:0033920 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005401 name: capsular-polysaccharide endo-1,3-alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: random hydrolysis of 1,3-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide." [EC:3.2.1.87] synonym: "aerobacter-capsular-polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87] synonym: "capsular polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87] synonym: "polysaccharide depolymerase activity" EXACT [EC:3.2.1.87] xref: EC:3.2.1.87 xref: GO:0033921 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005402 name: peptidoglycan beta-N-acetylmuramidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing N-acetylmuramic residues." [EC:3.2.1.92] synonym: "beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity" EXACT [EC:3.2.1.92] synonym: "exo-beta-acetylmuramidase activity" EXACT [EC:3.2.1.92] synonym: "exo-beta-N-acetylmuramidase activity" EXACT [EC:3.2.1.92] synonym: "peptidoglycan beta-N-acetylmuramoylexohydrolase activity" EXACT [EC:3.2.1.92] xref: EC:3.2.1.92 xref: GO:0033922 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005403 name: glucan 1,6-alpha-isomaltosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,6-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains." [EC:3.2.1.94] synonym: "1,6-alpha-D-glucan isomaltohydrolase activity" EXACT [EC:3.2.1.94] synonym: "exo-isomaltohydrolase activity" EXACT [EC:3.2.1.94] synonym: "G2-dextranase activity" EXACT [EC:3.2.1.94] synonym: "isomalto-dextranase activity" EXACT [EC:3.2.1.94] synonym: "isomaltodextranase activity" EXACT [EC:3.2.1.94] xref: EC:3.2.1.94 xref: GO:0033923 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005404 name: dextran 1,6-alpha-isomaltotriosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,6-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains." [EC:3.2.1.95] synonym: "1,6-alpha-D-glucan isomaltotriohydrolase activity" EXACT [EC:3.2.1.95] synonym: "exo-isomaltotriohydrolase activity" EXACT [EC:3.2.1.95] xref: EC:3.2.1.95 xref: GO:0033924 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005405 name: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96] synonym: "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-(1->4)-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase D activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase F activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase H activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase L activity" EXACT [EC:3.2.1.96] synonym: "endo-N-acetyl-beta-D-glucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endoglycosidase H activity" EXACT [EC:3.2.1.96] synonym: "endoglycosidase S activity" EXACT [EC:3.2.1.96] synonym: "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96] synonym: "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96] synonym: "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity" EXACT [EC:3.2.1.96] synonym: "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity" EXACT [EC:3.2.1.96] synonym: "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] xref: EC:3.2.1.96 xref: GO:0033925 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005406 name: glycopeptide alpha-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of terminal D-galactosyl-N-acetyl-alpha-D-galactosaminidic residues from a variety of glycopeptides and glycoproteins." [EC:3.2.1.97] synonym: "D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity" EXACT [EC:3.2.1.97] synonym: "endo-alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.97] synonym: "endo-alpha-N-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97] xref: EC:3.2.1.97 xref: GO:0033926 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005407 name: glucan 1,4-alpha-maltohexaosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends." [EC:3.2.1.98] synonym: "1,4-alpha-D-glucan maltohexaohydrolase activity" EXACT [EC:3.2.1.98] synonym: "exo-maltohexaohydrolase activity" EXACT [EC:3.2.1.98] synonym: "G6-amylase activity" EXACT [EC:3.2.1.98] synonym: "maltohexaose-producing amylase activity" EXACT [EC:3.2.1.98] xref: EC:3.2.1.98 xref: GO:0033927 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005408 name: mannan 1,4-mannobiosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-mannosidic linkages in 1,4-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends." [EC:3.2.1.100] synonym: "1,4-beta-D-mannan mannobiohydrolase activity" BROAD [EC:3.2.1.100] synonym: "exo-1,4-beta-mannobiohydrolase activity" EXACT [EC:3.2.1.100] synonym: "exo-beta-mannanase activity" EXACT [EC:3.2.1.100] synonym: "mannan 1,4-beta-mannobiosidase activity" EXACT [EC:3.2.1.100] xref: EC:3.2.1.100 xref: GO:0033928 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005409 name: blood-group-substance endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-galactosidic linkages in blood group A and B substances." [EC:3.2.1.102] synonym: "blood-group-substance 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.102] synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.102] xref: EC:3.2.1.102 xref: GO:0033929 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005410 name: keratan-sulfate endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-galactosidic linkages in keratan sulfate." [EC:3.2.1.103] synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.103] synonym: "keratan sulfate endogalactosidase activity" EXACT [EC:3.2.1.103] synonym: "keratan-sulfate 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.103] synonym: "keratanase activity" EXACT [EC:3.2.1.103] xref: EC:3.2.1.103 xref: GO:0033930 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005411 name: endogalactosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,4-alpha-D-galactosaminidic linkages in poly(D-galactosamine)." [EC:3.2.1.109] synonym: "galactosaminoglycan glycanohydrolase activity" EXACT [EC:3.2.1.109] xref: EC:3.2.1.109 xref: GO:0033931 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005412 name: 1,3-alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,3-linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111] synonym: "3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity" EXACT [EC:3.2.1.111] synonym: "almond emulsin fucosidase I activity" EXACT [EC:3.2.1.111] xref: EC:3.2.1.111 xref: GO:0033932 is_a: CCO:F0000945 ! alpha-L-fucosidase activity [Term] id: CCO:F0005413 name: branched-dextran exo-1,2-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,2-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose." [EC:3.2.1.115] synonym: "1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity" EXACT [EC:3.2.1.115] synonym: "dextran 1,2-alpha-glucosidase activity" EXACT [EC:3.2.1.115] synonym: "dextran alpha-1,2 debranching enzyme" RELATED [EC:3.2.1.115] xref: EC:3.2.1.115 xref: GO:0033933 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005414 name: glucan 1,4-alpha-maltotriohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends." [EC:3.2.1.116] synonym: "1,4-alpha-D-glucan maltotriohydrolase activity" EXACT [EC:3.2.1.116] synonym: "exo-maltotriohydrolase activity" EXACT [EC:3.2.1.116] synonym: "maltotriohydrolase activity" EXACT [EC:3.2.1.116] xref: EC:3.2.1.116 xref: GO:0033934 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005415 name: oligoxyloglucan beta-glycosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends." [EC:3.2.1.120] synonym: "isoprimeverose-producing oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120] synonym: "oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120] synonym: "oligoxyloglucan xyloglucohydrolase activity" EXACT [EC:3.2.1.120] xref: EC:3.2.1.120 xref: GO:0033935 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005416 name: polymannuronate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of the D-mannuronide linkages of polymannuronate." [EC:3.2.1.121] synonym: "poly(mannuronide) mannuronohydrolase activity" EXACT [EC:3.2.1.121] synonym: "polymannuronic acid polymerase activity" EXACT [EC:3.2.1.121] xref: EC:3.2.1.121 xref: GO:0033936 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005417 name: 3-deoxy-2-octulosonidase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides." [EC:3.2.1.124] synonym: "2-keto-3-deoxyoctonate hydrolase activity" EXACT [EC:3.2.1.124] synonym: "capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity" EXACT [EC:3.2.1.124] synonym: "octulofuranosylono hydrolase activity" EXACT [EC:3.2.1.124] synonym: "octulopyranosylonohydrolase activity" EXACT [EC:3.2.1.124] synonym: "octulosylono hydrolase activity" EXACT [EC:3.2.1.124] xref: EC:3.2.1.124 xref: GO:0033937 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005418 name: 1,6-alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,6-linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin." [EC:3.2.1.127] synonym: "1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity" EXACT [EC:3.2.1.127] xref: EC:3.2.1.127 xref: GO:0033938 is_a: CCO:F0000945 ! alpha-L-fucosidase activity [Term] id: CCO:F0005419 name: xylan alpha-1,2-glucuronosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of alpha-D-1,2-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans." [EC:3.2.1.131] synonym: "1,2-alpha-glucuronidase activity" EXACT [EC:3.2.1.131] synonym: "alpha-(1->2)-glucuronidase activity" EXACT [EC:3.2.1.131] synonym: "xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity" EXACT [EC:3.2.1.131] xref: EC:3.2.1.131 xref: GO:0033939 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005420 name: glucuronoarabinoxylan endo-1,4-beta-xylanase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-xylosyl links in some glucuronoarabinoxylans." [EC:3.2.1.136] synonym: "endoarabinoxylanase activity" EXACT [EC:3.2.1.136] synonym: "feraxan endoxylanase activity" EXACT [EC:3.2.1.136] synonym: "feraxanase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoxylan xylanohydrolase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoxylan xylohydrolase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoxylanase activity" EXACT [EC:3.2.1.136] xref: EC:3.2.1.136 xref: GO:0033940 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005421 name: mannan exo-1,2-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,2-alpha-D- and 1,6-alpha-D- linkages in yeast mannan, releasing D-mannose." [EC:3.2.1.137] synonym: "1,2-1,6-alpha-D-mannan D-mannohydrolase activity" EXACT [EC:3.2.1.137] synonym: "exo-1,2-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.137] xref: EC:3.2.1.137 xref: GO:0033941 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005422 name: 4-alpha-D-\{(1->4)-alpha-D-glucano}trehalose trehalohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan." [EC:3.2.1.141] synonym: "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" EXACT [EC:3.2.1.141] synonym: "malto-oligosyltrehalose trehalohydrolase activity" EXACT [EC:3.2.1.141] synonym: "maltooligosyl trehalose trehalohydrolase activity" EXACT [EC:3.2.1.141] xref: EC:3.2.1.141 xref: GO:0033942 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005423 name: galactan 1,3-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans." [EC:3.2.1.145] synonym: "galactan (1->3)-beta-D-galactosidase activity" EXACT [EC:3.2.1.145] xref: EC:3.2.1.145 xref: GO:0033943 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005424 name: beta-galactofuranosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose." [EC:3.2.1.146] synonym: "beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146] synonym: "beta-D-galactofuranoside hydrolase activity" EXACT [EC:3.2.1.146] synonym: "exo-beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146] synonym: "exo-beta-galactofuranosidase activity" EXACT [EC:3.2.1.146] xref: EC:3.2.1.146 xref: GO:0033944 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005425 name: oligoxyloglucan reducing-end-specific cellobiohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-1,4-linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted." [EC:3.2.1.150] synonym: "oligoxyloglucan reducing end-specific cellobiohydrolase activity" EXACT [EC:3.2.1.150] synonym: "oligoxyloglucan reducing-end cellobiohydrolase activity" EXACT [EC:3.2.1.150] xref: EC:3.2.1.150 xref: GO:0033945 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005426 name: xyloglucan-specific endo-beta-1,4-glucanase activity namespace: molecular_function def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides (endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan)." [EC:3.2.1.151] synonym: "1,4-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151] synonym: "[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151] synonym: "XEG" RELATED [EC:3.2.1.151] synonym: "XH" RELATED [EC:3.2.1.151] synonym: "xyloglucan endo-beta-1,4-glucanase activity" EXACT [EC:3.2.1.151] synonym: "xyloglucanase activity" EXACT [EC:3.2.1.151] synonym: "xyloglucanendohydrolase activity" EXACT [EC:3.2.1.151] xref: EC:3.2.1.151 xref: GO:0033946 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005427 name: mannosylglycoprotein endo-beta-mannosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences." [EC:3.2.1.152] synonym: "endo-beta-mannosidase activity" EXACT [EC:3.2.1.152] xref: EC:3.2.1.152 xref: GO:0033947 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005428 name: fructan beta-(2,1)-fructosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing 2,1-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.153] synonym: "1-FEH II" RELATED [EC:3.2.1.153] synonym: "1-FEH w1" RELATED [EC:3.2.1.153] synonym: "1-FEH w2" RELATED [EC:3.2.1.153] synonym: "1-fructan exohydrolase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2,1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2-1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2-1)-linkage-specific fructan-beta-fructosidase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2-1)fructan exohydrolase activity" EXACT [EC:3.2.1.153] xref: EC:3.2.1.153 xref: GO:0033948 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005429 name: fructan beta-(2,6)-fructosidase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.154] synonym: "6-FEH" RELATED [EC:3.2.1.154] synonym: "beta-(2,6)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.154] synonym: "beta-(2-6)-fructan exohydrolase activity" EXACT [EC:3.2.1.154] xref: EC:3.2.1.154 xref: GO:0033949 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005430 name: xyloglucan-specific exo-beta-1,4-glucanase activity namespace: molecular_function def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides (exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan)." [EC:3.2.1.155] synonym: "[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity" EXACT [EC:3.2.1.155] synonym: "Cel74A" RELATED [EC:3.2.1.155] xref: EC:3.2.1.155 xref: GO:0033950 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005431 name: oligosaccharide reducing-end xylanase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides." [EC:3.2.1.156] synonym: "beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity" EXACT [EC:3.2.1.156] synonym: "reducing end xylose-releasing exo-oligoxylanase activity" EXACT [EC:3.2.1.156] synonym: "Rex" RELATED [EC:3.2.1.156] xref: EC:3.2.1.156 xref: GO:0033951 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005432 name: iota-carrageenase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans." [EC:3.2.1.157] synonym: "iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity" EXACT [EC:3.2.1.157] xref: EC:3.2.1.157 xref: GO:0033952 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005433 name: alpha-agarase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product." [EC:3.2.1.158] synonym: "agarase A33 activity" NARROW [EC:3.2.1.158] synonym: "agarase activity" BROAD [EC:3.2.1.158] synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.158] xref: EC:3.2.1.158 xref: GO:0033953 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005434 name: alpha-neoagaro-oligosaccharide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose." [EC:3.2.1.159] synonym: "alpha-NAOS hydrolase activity" EXACT [EC:3.2.1.159] synonym: "alpha-neoagaro-oligosaccharide 3-glycohydrolase activity" EXACT [EC:3.2.1.159] synonym: "alpha-neoagarooligosaccharide hydrolase activity" EXACT [EC:3.2.1.159] xref: EC:3.2.1.159 xref: GO:0033954 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005435 name: beta-apiosyl-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose." [EC:3.2.1.161] synonym: "7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity" EXACT [EC:3.2.1.161] synonym: "furcatin hydrolase activity" EXACT [EC:3.2.1.161] synonym: "isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity" EXACT [EC:3.2.1.161] synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity" EXACT [EC:3.2.1.161] xref: EC:3.2.1.161 xref: GO:0033956 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005436 name: lambda-carrageenase activity namespace: molecular_function def: "Catalysis of the reaction: endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S." [EC:3.2.1.162] synonym: "endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity" EXACT [EC:3.2.1.162] xref: EC:3.2.1.162 xref: GO:0033957 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005437 name: DNA-deoxyinosine glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolyses DNA and polynucleotides, releasing free hypoxanthine." [EC:3.2.2.15] synonym: "deoxyribonucleic acid glycosylase activity" EXACT [EC:3.2.2.15] synonym: "DNA(hypoxanthine) glycohydrolase activity" EXACT [EC:3.2.2.15] synonym: "DNA-deoxyinosine deoxyribohydrolase activity" EXACT [EC:3.2.2.15] synonym: "DNA-deoxyinosine glycosidase activity" EXACT [EC:3.2.2.15] synonym: "hypoxanthine-DNA glycosylase activity" EXACT [EC:3.2.2.15] xref: EC:3.2.2.15 xref: GO:0033958 is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0005438 name: deoxyribodipyrimidine endonucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: cleaves the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue." [EC:3.2.2.17] synonym: "deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity" EXACT [EC:3.2.2.17] synonym: "deoxyribonucleate pyrimidine dimer glycosidase activity" EXACT [EC:3.2.2.17] synonym: "endonuclease V activity" BROAD [EC:3.2.2.17] synonym: "PD-DNA glycosylase activity" EXACT [EC:3.2.2.17] synonym: "pyrimidine dimer DNA glycosylase activity" EXACT [EC:3.2.2.17] synonym: "pyrimidine dimer DNA-glycosylase activity" EXACT [EC:3.2.2.17] synonym: "T4-induced UV endonuclease activity" EXACT [EC:3.2.2.17] xref: EC:3.2.2.17 xref: GO:0033959 is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0005439 name: N-methyl nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylxanthosine + H2O = 7-methylxanthine + D-ribose." [EC:3.2.2.25] synonym: "7-methylxanthosine nucleosidase activity" EXACT [EC:3.2.2.25] synonym: "7-methylxanthosine ribohydrolase activity" EXACT [EC:3.2.2.25] synonym: "methylpurine nucleosidase activity" EXACT [EC:3.2.2.25] synonym: "N-MeNase activity" EXACT [EC:3.2.2.25] synonym: "N-methyl nucleoside hydrolase activity" EXACT [EC:3.2.2.25] xref: EC:3.2.2.25 xref: GO:0033960 is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0005440 name: cis-stilbene-oxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "cis-epoxide hydrolase activity" EXACT [EC:3.3.2.9] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "mEH" RELATED [EC:3.3.2.9] synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9] xref: EC:3.3.2.9 xref: GO:0033961 is_a: CCO:F0003373 ! ether hydrolase activity [Term] id: CCO:F0005441 name: cholesterol-5,6-oxide hydrolase activity namespace: molecular_function def: "Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol." [EC:3.3.2.11] synonym: "5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity" EXACT [EC:3.3.2.11] synonym: "ChEH" RELATED [EC:3.3.2.11] synonym: "cholesterol-epoxide hydrolase activity" EXACT [EC:3.3.2.11] xref: EC:3.3.2.11 xref: GO:0033963 is_a: CCO:F0003373 ! ether hydrolase activity [Term] id: CCO:F0005442 name: glycosphingolipid deacylase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives." [EC:3.5.1.69] synonym: "glycosphingolipid amidohydrolase activity" EXACT [EC:3.5.1.69] synonym: "glycosphingolipid ceramide deacylase activity" BROAD [EC:3.5.1.69] xref: EC:3.5.1.69 xref: GO:0033964 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005443 name: aculeacin-A deacylase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain." [EC:3.5.1.70] synonym: "aculeacin A acylase activity" EXACT [EC:3.5.1.70] synonym: "aculeacin-A amidohydrolase activity" EXACT [EC:3.5.1.70] xref: EC:3.5.1.70 xref: GO:0033965 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005444 name: N-substituted formamide deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine." [EC:3.5.1.91] synonym: "N-benzylformamide amidohydrolase activity" EXACT [EC:3.5.1.91] synonym: "NfdA" RELATED [EC:3.5.1.91] xref: GO:0033966 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005445 name: glutaryl-7-aminocephalosporanic-acid acylase activity namespace: molecular_function def: "Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate." [EC:3.5.1.93] synonym: "(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity" EXACT [EC:3.5.1.93] synonym: "7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity" EXACT [EC:3.5.1.93] synonym: "CA" RELATED [EC:3.5.1.93] synonym: "cephalosporin acylase activity" EXACT [EC:3.5.1.93] synonym: "cephalosporin C acylase activity" EXACT [EC:3.5.1.93] synonym: "GA" RELATED [EC:3.5.1.93] synonym: "GCA" RELATED [EC:3.5.1.93] synonym: "GL-7-ACA acylase activity" EXACT [EC:3.5.1.93] synonym: "glutaryl-7-ACA acylase activity" EXACT [EC:3.5.1.93] synonym: "glutaryl-7-aminocephalosporanic acid acylase activity" EXACT [EC:3.5.1.93] xref: EC:3.5.1.93 xref: GO:0033968 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005446 name: gamma-glutamyl-gamma-aminobutyrate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate." [EC:3.5.1.94] synonym: "4-(glutamylamino)butanoate amidohydrolase activity" EXACT [EC:3.5.1.94] synonym: "gamma-glutamyl-GABA hydrolase activity" EXACT [EC:3.5.1.94] synonym: "PuuD" RELATED [EC:3.5.1.94] synonym: "YcjL" RELATED [EC:3.5.1.94] xref: EC:3.5.1.94 xref: GO:0033969 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005447 name: N-malonylurea hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H2O = malonate + urea." [EC:3.5.1.95] synonym: "3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity" EXACT [EC:3.5.1.95] synonym: "ureidomalonase activity" EXACT [EC:3.5.1.95] xref: EC:3.5.1.95 xref: GO:0033970 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005448 name: hydroxyisourate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate." [EC:3.5.2.17] synonym: "5-hydroxyisourate amidohydrolase activity" EXACT [EC:3.5.2.17] synonym: "5-hydroxyisourate hydrolase activity" EXACT [EC:3.5.2.17] synonym: "HIUHase activity" EXACT [EC:3.5.2.17] xref: EC:3.5.2.17 xref: GO:0033971 is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0005449 name: proclavaminate amidinohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: amidinoproclavaminate + H2O = proclavaminate + urea." [EC:3.5.3.22] synonym: "PAH" RELATED [EC:3.5.3.22] synonym: "proclavaminate amidino hydrolase activity" EXACT [EC:3.5.3.22] synonym: "proclavaminic acid amidino hydrolase activity" EXACT [EC:3.5.3.22] xref: EC:3.5.3.22 xref: GO:0033972 is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0005450 name: dCTP deaminase (dUMP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + 2 H2O = dUMP + diphosphate + NH3." [EC:3.5.4.30] synonym: "dCTP aminohydrolase (dUMP-forming) activity" EXACT [EC:3.5.4.30] xref: EC:3.5.4.30 xref: GO:0033973 is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0005451 name: nucleoside phosphoacylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolyses mixed phospho-anhydride bonds." [EC:3.6.1.24] synonym: "nucleoside-5'-phosphoacylate acylhydrolase activity" EXACT [EC:3.6.1.24] xref: EC:3.6.1.24 xref: GO:0033974 is_a: CCO:F0003386 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: CCO:F0005453 name: 2-haloacid dehalogenase (configuration-inverting) activity namespace: molecular_function def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.10] synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.10] synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.10] synonym: "DL-2-haloacid dehalogenase (inversion of configuration) activity" EXACT [EC:3.8.1.10] synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.10] synonym: "DL-2-haloacid halidohydrolase (inversion of configuration) activity" EXACT [EC:3.8.1.10] synonym: "DL-DEXi" RELATED [EC:3.8.1.10] xref: EC:3.8.1.10 xref: GO:0033976 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0005454 name: 2-haloacid dehalogenase (configuration-retaining) activity namespace: molecular_function def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.11] synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.11] synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.11] synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.11] synonym: "DL-DEXr" RELATED [EC:3.8.1.11] xref: EC:3.8.1.11 xref: GO:0033977 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0005455 name: phosphonopyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphonopyruvate + H2O = pyruvate + phosphate." [EC:3.11.1.3] synonym: "PPH" RELATED [EC:3.11.1.3] xref: EC:3.11.1.3 xref: GO:0033978 is_a: CCO:F0003394 ! hydrolase activity, acting on acid carbon-phosphorus bonds [Term] id: CCO:F0005456 name: phosphonopyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2." [EC:4.1.1.82] synonym: "3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity" EXACT [EC:4.1.1.82] synonym: "3-phosphonopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.82] xref: EC:4.1.1.82 xref: GO:0033980 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0005457 name: D-dopachrome decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: D-dopachrome = 5,6-dihydroxyindole + CO2." [EC:4.1.1.84] synonym: "D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity" EXACT [EC:4.1.1.84] synonym: "D-dopachrome carboxy-lyase activity" EXACT [EC:4.1.1.84] synonym: "D-dopachrome tautomerase activity" EXACT [EC:4.1.1.84] synonym: "D-tautomerase activity" EXACT [EC:4.1.1.84] synonym: "phenylpyruvate tautomerase II activity" EXACT [EC:4.1.1.84] xref: EC:4.1.1.84 xref: GO:0033981 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0005458 name: 3-dehydro-L-gulonate-6-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2." [EC:4.1.1.85] synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity" EXACT [EC:4.1.1.85] synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.85] synonym: "3-keto-L-gulonate 6-phosphate decarboxylase activity" EXACT [EC:4.1.1.85] synonym: "KGPDC" RELATED [EC:4.1.1.85] synonym: "SgaH" RELATED [EC:4.1.1.85] synonym: "SgbH" RELATED [EC:4.1.1.85] synonym: "UlaD" RELATED [EC:4.1.1.85] xref: EC:4.1.1.85 xref: GO:0033982 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0005459 name: diaminobutyrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,4-diaminobutanoate = propane-1,3-diamine + CO2." [EC:4.1.1.86] synonym: "DABA DC" RELATED [EC:4.1.1.86] synonym: "L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity" EXACT [EC:4.1.1.86] synonym: "L-2,4-diaminobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.86] synonym: "L-2,4-diaminobutyrate decarboxylase activity" EXACT [EC:4.1.1.86] xref: EC:4.1.1.86 xref: GO:0033983 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0005460 name: indole-3-glycerol-phosphate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate." [EC:4.1.2.8] synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity" EXACT [EC:4.1.2.8] synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8] synonym: "BX1" RELATED [EC:4.1.2.8] synonym: "IGL" RELATED [EC:4.1.2.8] synonym: "indole glycerol phosphate hydrolase activity" EXACT [EC:4.1.2.8] synonym: "indole synthase activity" EXACT [EC:4.1.2.8] synonym: "indole-3-glycerol phosphate lyase activity" EXACT [EC:4.1.2.8] synonym: "indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8] synonym: "indoleglycerolphosphate aldolase activity" EXACT [EC:4.1.2.8] synonym: "tryptophan synthase alpha activity" EXACT [EC:4.1.2.8] synonym: "TSA" RELATED [EC:4.1.2.8] xref: EC:4.1.2.8 xref: GO:0033984 is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0005461 name: 2-hydroxyisoflavanone dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O." [EC:4.2.1.105] synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity" EXACT [EC:4.2.1.105] synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase activity" EXACT [EC:4.2.1.105] xref: EC:4.2.1.105 xref: GO:0033987 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005462 name: bile-acid 7alpha-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate = 12alpha-hydroxy-3-oxochola-4,6-dienoate + H2O." [EC:4.2.1.106] synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity" EXACT [EC:4.2.1.106] synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity" EXACT [EC:4.2.1.106] synonym: "BA7 alpha dehydratase activity" EXACT [EC:4.2.1.106] xref: EC:4.2.1.106 xref: GO:0033988 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005463 name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107] synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity" EXACT [EC:4.2.1.107] synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.107] synonym: "46 kDa hydratase 2 activity" EXACT [EC:4.2.1.107] synonym: "D-3-hydroxyacyl-CoA dehydratase activity" BROAD [EC:4.2.1.107] xref: EC:4.2.1.107 xref: GO:0033989 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005464 name: ectoine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N4-acetyl-L-2,4-diaminobutanoate = L-ectoine + H2O." [EC:4.2.1.108] synonym: "4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108] synonym: "EctC" RELATED [EC:4.2.1.108] synonym: "L-ectoine synthase activity" EXACT [EC:4.2.1.108] synonym: "N-acetyldiaminobutanoate dehydratase activity" EXACT [EC:4.2.1.108] synonym: "N-acetyldiaminobutyrate dehydratase activity" EXACT [EC:4.2.1.108] synonym: "N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108] xref: EC:4.2.1.108 xref: GO:0033990 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005465 name: aldos-2-ulose dehydratase activity namespace: molecular_function def: "Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O (overall reaction), (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one." [EC:4.2.1.110] synonym: "1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity" EXACT [EC:4.2.1.110] synonym: "1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity" EXACT [EC:4.2.1.110] synonym: "AUDH" RELATED [EC:4.2.1.110] synonym: "pyranosone dehydratase activity" EXACT [EC:4.2.1.110] xref: EC:4.2.1.110 xref: GO:0033991 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005466 name: 1,5-anhydro-D-fructose dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O." [EC:4.2.1.111] synonym: "1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose 4-dehydratase activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose hydro-lyase activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose hydrolyase activity" EXACT [EC:4.2.1.111] synonym: "AF dehydratase activity" EXACT [EC:4.2.1.111] synonym: "AFDH" RELATED [EC:4.2.1.111] xref: EC:4.2.1.111 xref: GO:0033992 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005467 name: glucuronan lyase activity namespace: molecular_function def: "Catalysis of the reaction: Eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides." [EC:4.2.2.14] synonym: "(1,4)-beta-D-glucuronan lyase activity" EXACT [EC:4.2.2.14] xref: EC:4.2.2.14 xref: GO:0033994 is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0005468 name: anhydrosialidase activity namespace: molecular_function def: "Catalysis of the reaction: Elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate." [EC:4.2.2.15] synonym: "anhydroneuraminidase activity" EXACT [EC:4.2.2.15] synonym: "glycoconjugate sialyl-lyase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15] synonym: "sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15] synonym: "sialidase L activity" EXACT [EC:4.2.2.15] xref: EC:4.2.2.15 xref: GO:0033995 is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0005469 name: levan fructotransferase (DFA-IV-forming) activity namespace: molecular_function def: "Catalysis of the reaction: Produces di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.16] synonym: "2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity" EXACT [EC:4.2.2.16] synonym: "2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity" EXACT [EC:4.2.2.16] synonym: "levan fructotransferase activity" EXACT [EC:4.2.2.16] xref: EC:4.2.2.16 xref: GO:0033996 is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0005470 name: inulin fructotransferase (DFA-I-forming) activity namespace: molecular_function def: "Catalysis of the reaction: Produces alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.17] synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity" EXACT [EC:4.2.2.17] synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity" EXACT [EC:4.2.2.17] synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity" EXACT [EC:4.2.2.17] synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity" EXACT [EC:4.2.2.17] synonym: "inulin fructotransferase (DFA-I-producing) activity" EXACT [EC:4.2.2.17] xref: EC:4.2.2.17 xref: GO:0033997 is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0005471 name: inulin fructotransferase (DFA-III-forming) activity namespace: molecular_function def: "Catalysis of the reaction: Produces alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.18] synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] synonym: "inulase II activity" EXACT [EC:4.2.2.18] synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity" EXACT [EC:4.2.2.18] synonym: "inulin fructotransferase (depolymerizing) activity" EXACT [EC:4.2.2.18] synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] synonym: "inulin fructotransferase (DFA-III-producing) activity" EXACT [EC:4.2.2.18] synonym: "inulinase II activity" EXACT [EC:4.2.2.18] xref: EC:4.2.2.18 xref: GO:0033998 is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0005472 name: chondroitin B lyase activity namespace: molecular_function def: "Catalysis of the reaction: Eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S)." [EC:4.2.2.19] synonym: "ChnB" RELATED [EC:4.2.2.19] synonym: "chonB" RELATED [EC:4.2.2.19] synonym: "chondroitinase B activity" EXACT [EC:4.2.2.19] xref: EC:4.2.2.19 xref: GO:0033999 is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0005473 name: chondroitin-sulfate-ABC endolyase activity namespace: molecular_function def: "Catalysis of the reaction: Endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides." [EC:4.2.2.20] synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.20] synonym: "chondroitin sulfate ABC endoeliminase activity" EXACT [EC:4.2.2.20] synonym: "chondroitin sulfate ABC endolyase activity" EXACT [EC:4.2.2.20] synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.20] synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.20] synonym: "chondroitinase activity" BROAD [EC:4.2.2.20] synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.20] synonym: "ChS ABC lyase I activity" EXACT [EC:4.2.2.20] xref: EC:4.2.2.20 xref: GO:0034000 is_a: CCO:F0006792 ! chondroitin ABC lyase activity [Term] id: CCO:F0005474 name: chondroitin-sulfate-ABC exolyase activity namespace: molecular_function def: "Catalysis of the reaction: Exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments." [EC:4.2.2.21] synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.21] synonym: "chondroitin sulfate ABC exoeliminase activity" EXACT [EC:4.2.2.21] synonym: "chondroitin sulfate ABC exolyase activity" EXACT [EC:4.2.2.21] synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.21] synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.21] synonym: "chondroitinase activity" BROAD [EC:4.2.2.21] synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.21] synonym: "ChS ABC lyase II activity" EXACT [EC:4.2.2.21] xref: EC:4.2.2.21 xref: GO:0034001 is_a: CCO:F0006792 ! chondroitin ABC lyase activity [Term] id: CCO:F0005476 name: vetispiradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = vetispiradiene + diphosphate." [EC:4.2.3.21] synonym: "HVS" RELATED [EC:4.2.3.21] synonym: "pemnaspirodiene synthase activity" EXACT [EC:4.2.3.21] synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity" EXACT [EC:4.2.3.21] synonym: "vetispiradiene cyclase activity" EXACT [EC:4.2.3.21] synonym: "vetispiradiene-forming farnesyl pyrophosphate cyclase activity" EXACT [EC:4.2.3.21] xref: EC:4.2.3.21 xref: GO:0034003 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005477 name: germacradienol synthase activity namespace: molecular_function def: "Catalysis of the reactions: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate and 2-trans,6-trans-farnesyl diphosphate = (-)-(7S)-germacrene D + diphosphate." [EC:4.2.3.22] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity" EXACT [EC:4.2.3.22] synonym: "germacradienol/germacrene-D synthase activity" EXACT [EC:4.2.3.22] xref: EC:4.2.3.22 xref: GO:0034004 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005478 name: germacrene-A synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate." [EC:4.2.3.23] synonym: "(+)-(10R)-germacrene A synthase activity" EXACT [EC:4.2.3.23] synonym: "(+)-germacrene A synthase activity" EXACT [EC:4.2.3.23] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity" EXACT [EC:4.2.3.23] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity" EXACT [EC:4.2.3.23] synonym: "GAS" RELATED [EC:4.2.3.23] synonym: "germacrene A synthase activity" EXACT [EC:4.2.3.23] xref: EC:4.2.3.23 xref: GO:0034005 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005479 name: amorpha-4,11-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate." [EC:4.2.3.24] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity" EXACT [EC:4.2.3.24] synonym: "amorphadiene synthase activity" EXACT [EC:4.2.3.24] xref: EC:4.2.3.24 xref: GO:0034006 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005480 name: S-linalool synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H2O = (3S)-linalool + diphosphate." [EC:4.2.3.25] synonym: "3S-linalool synthase activity" EXACT [EC:4.2.3.25] synonym: "geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity" EXACT [EC:4.2.3.25] synonym: "LIS" RELATED [EC:4.2.3.25] synonym: "Lis" RELATED [EC:4.2.3.25] xref: EC:4.2.3.25 xref: GO:0034007 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005481 name: R-linalool synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H2O = (3R)-linalool + diphosphate." [EC:4.2.3.26] synonym: "(-)-3R-linalool synthase activity" EXACT [EC:4.2.3.26] synonym: "(3R)-linalool synthase activity" EXACT [EC:4.2.3.26] synonym: "geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity" EXACT [EC:4.2.3.26] xref: EC:4.2.3.26 xref: GO:0034008 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005482 name: isoprene synthase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate = isoprene + diphosphate." [EC:4.2.3.27] synonym: "dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity" EXACT [EC:4.2.3.27] synonym: "ISPC" RELATED [EC:4.2.3.27] synonym: "ISPS" RELATED [EC:4.2.3.27] xref: EC:4.2.3.27 xref: GO:0034009 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005483 name: sulfolactate sulfo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfolactate = pyruvate + bisulfite." [EC:4.4.1.24] synonym: "3-sulfolactate bisulfite-lyase (pyruvate-forming) activity" EXACT [EC:4.4.1.24] synonym: "3-sulfolactate bisulfite-lyase activity" EXACT [EC:4.4.1.24] synonym: "Suy" RELATED [EC:4.4.1.24] synonym: "SuyAB" RELATED [EC:4.4.1.24] xref: EC:4.4.1.24 xref: GO:0034010 is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0005484 name: L-cysteate sulfo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteate + H2O = pyruvate + bisulfite + NH3." [EC:4.4.1.25] synonym: "CuyA" RELATED [EC:4.4.1.25] synonym: "L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity" EXACT [EC:4.4.1.25] synonym: "L-cysteate sulfo-lyase (deaminating) activity" EXACT [EC:4.4.1.25] xref: EC:4.4.1.25 xref: GO:0034011 is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0005485 name: FAD-AMP lyase (cyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate." [EC:4.6.1.15] synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" EXACT [EC:4.6.1.15] synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" EXACT [EC:4.6.1.15] synonym: "FMN cyclase activity" EXACT [EC:4.6.1.15] xref: EC:4.6.1.15 xref: GO:0034012 is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003413 ! phosphorus-oxygen lyase activity [Term] id: CCO:F0005486 name: aliphatic aldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O." [EC:4.99.1.5] synonym: "aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity" EXACT [EC:4.99.1.5] synonym: "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.99.1.5] synonym: "OxdA" RELATED [EC:4.99.1.5] xref: EC:4.99.1.5 xref: GO:0034013 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0005487 name: L-ribulose-5-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate." [EC:5.1.3.22] synonym: "L-xylulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.22] synonym: "SgaU" RELATED [EC:5.1.3.22] synonym: "UlaE" RELATED [EC:5.1.3.22] xref: EC:5.1.3.22 xref: GO:0034015 is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0005488 name: polyenoic fatty acid isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,8E,14Z,17Z)-eicosapentaenoate." [EC:5.3.3.13] synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity" EXACT [EC:5.3.3.13] synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13] synonym: "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13] synonym: "eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity" EXACT [EC:5.3.3.13] synonym: "PFI" RELATED [EC:5.3.3.13] xref: EC:5.3.3.13 xref: GO:0034016 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0005489 name: trans-2-decenoyl-acyl-carrier-protein isomerase activity namespace: molecular_function def: "Catalysis of the reaction: trans-dec-2-enoyl-acyl-carrier-protein = cis-dec-3-enoyl-acyl-carrier-protein." [EC:5.3.3.14] synonym: "beta-hydroxydecanoyl thioester dehydrase activity" BROAD [EC:5.3.3.14] synonym: "decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity" EXACT [EC:5.3.3.14] synonym: "FabM" RELATED [EC:5.3.3.14] synonym: "trans-2,cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] synonym: "trans-2-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] xref: EC:5.3.3.14 xref: GO:0034017 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0005490 name: ascopyrone tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose." [EC:5.3.3.15] synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity" EXACT [EC:5.3.3.15] synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity" EXACT [EC:5.3.3.15] synonym: "APM tautomerase activity" EXACT [EC:5.3.3.15] synonym: "APTM" RELATED [EC:5.3.3.15] synonym: "ascopyrone intramolecular oxidoreductase activity" EXACT [EC:5.3.3.15] synonym: "ascopyrone isomerase activity" EXACT [EC:5.3.3.15] synonym: "ascopyrone P tautomerase activity" EXACT [EC:5.3.3.15] xref: EC:5.3.3.15 xref: GO:0034018 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0005491 name: capsanthin/capsorubin synthase activity namespace: molecular_function def: "Catalysis of the reactions: violaxanthin = capsorubin and antheraxanthin = capsanthin." [EC:5.3.99.8] synonym: "capsanthin-capsorubin synthase activity" EXACT [EC:5.3.99.8] synonym: "CCS" RELATED [EC:5.3.99.8] synonym: "ketoxanthophyll synthase activity" EXACT [EC:5.3.99.8] synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" EXACT [EC:5.3.99.8] xref: EC:5.3.99.8 xref: GO:0034019 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0005492 name: neoxanthin synthase activity namespace: molecular_function def: "Catalysis of the reaction: violaxanthin = neoxanthin." [EC:5.3.99.9] synonym: "NSY" RELATED [EC:5.3.99.9] synonym: "violaxanthin-neoxanthin isomerase (epoxide-opening) activity" EXACT [EC:5.3.99.9] xref: EC:5.3.99.9 xref: GO:0034020 is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0005493 name: 3-(hydroxyamino)phenol mutase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone." [EC:5.4.4.3] synonym: "3-(hydroxyamino)phenol hydroxymutase activity" EXACT [EC:5.4.4.3] synonym: "3-hydroxylaminophenol mutase activity" EXACT [EC:5.4.4.3] synonym: "3HAP mutase activity" EXACT [EC:5.4.4.3] xref: EC:5.4.4.3 xref: GO:0034022 is_a: CCO:F0007827 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: CCO:F0005494 name: 5-(carboxyamino)imidazole ribonucleotide mutase activity namespace: molecular_function def: "Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [EC:5.4.99.18] synonym: "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity" EXACT [EC:5.4.99.18] synonym: "class I PurE" RELATED [EC:5.4.99.18] synonym: "N5-CAIR mutase activity" EXACT [EC:5.4.99.18] synonym: "N5-carboxyaminoimidazole ribonucleotide mutase activity" EXACT [EC:5.4.99.18] synonym: "PurE" RELATED [EC:5.4.99.18] xref: EC:5.4.99.18 xref: GO:0034023 is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0005495 name: glutamate-putrescine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + putrescine = ADP + phosphate + gamma-L-glutamylputrescine." [EC:6.3.1.11] synonym: "gamma-glutamylputrescine synthetase activity" EXACT [EC:6.3.1.11] synonym: "L-glutamate:putrescine ligase (ADP-forming) activity" EXACT [EC:6.3.1.11] synonym: "YcjK" RELATED [EC:6.3.1.11] xref: EC:6.3.1.11 xref: GO:0034024 is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0005496 name: D-aspartate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate." [EC:6.3.1.12] synonym: "aslfm" RELATED [EC:6.3.1.12] synonym: "D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity" EXACT [EC:6.3.1.12] synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12] synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" EXACT [EC:6.3.1.12] xref: EC:6.3.1.12 xref: GO:0034025 is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0005497 name: L-amino-acid alpha-ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid." [EC:6.3.2.28] synonym: "bacilysin synthetase activity" EXACT [EC:6.3.2.28] synonym: "L-amino acid alpha-ligase activity" EXACT [EC:6.3.2.28] synonym: "L-amino acid ligase activity" EXACT [EC:6.3.2.28] synonym: "YwfE" RELATED [EC:6.3.2.28] xref: EC:6.3.2.28 xref: GO:0034026 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0005499 name: 5-(carboxyamino)imidazole ribonucleotide synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole." [EC:6.3.4.18] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.18] synonym: "N5-CAIR synthetase activity" EXACT [EC:6.3.4.18] synonym: "N5-carboxyaminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.4.18] synonym: "PurK" RELATED [EC:6.3.4.18] xref: EC:6.3.4.18 xref: GO:0034028 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0005500 name: 2-oxoglutarate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-oxoglutarate + HCO3- = ADP + phosphate + oxalosuccinate." [EC:6.4.1.7] synonym: "carboxylating factor for ICDH" RELATED [EC:6.4.1.7] synonym: "CFI" RELATED [EC:6.4.1.7] synonym: "OGC" RELATED [EC:6.4.1.7] synonym: "oxalosuccinate synthetase activity" EXACT [EC:6.4.1.7] xref: EC:6.4.1.7 xref: GO:0034029 is_a: CCO:F0003443 ! ligase activity, forming carbon-carbon bonds [Term] id: CCO:F0005501 name: deoxyhypusine synthase activity namespace: molecular_function def: "Catalysis of the reaction: eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [EC:2.5.1.46, GOC:pd, MetaCyc:2.5.1.46-RXN] comment: Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase ; GO:0050983'. synonym: "eIF-5A-deoxyhypusine synthase activity" EXACT [EC:2.5.1.46] synonym: "eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46] synonym: "spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46] xref: EC:2.5.1.46 xref: GO:0034038 xref: MetaCyc:2.5.1.46-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005502 name: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar." [GOC:mah, PMID:17641464] synonym: "8-oxoG DNA N-glycosylase activity" EXACT [] xref: GO:0034039 is_a: CCO:F0001984 ! oxidized purine base lesion DNA N-glycosylase activity [Term] id: CCO:F0005503 name: lipid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)." [GOC:rl] xref: GO:0034040 is_a: CCO:F0001556 ! lipid transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0005504 name: sterol-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)." [GOC:rl] xref: GO:0034041 is_a: CCO:F0002716 ! sterol transporter activity is_a: CCO:F0005503 ! lipid-transporting ATPase activity [Term] id: CCO:F0005505 name: 5-formyluracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] synonym: "5-foU DNA N-glycosylase activity" EXACT [] xref: GO:0034042 is_a: CCO:F0000096 ! oxidized pyrimidine base lesion DNA N-glycosylase activity [Term] id: CCO:F0005506 name: 5-hydroxymethyluracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] synonym: "5-hmU DNA N-glycosylase activity" EXACT [] xref: GO:0034043 is_a: CCO:F0000096 ! oxidized pyrimidine base lesion DNA N-glycosylase activity [Term] id: CCO:F0005507 name: poly(rG) binding namespace: molecular_function def: "Interacting selectively with a sequence of guanine residues in an RNA molecule." [GOC:mah] synonym: "poly(G) binding" BROAD [] xref: GO:0034046 is_a: CCO:F0000312 ! single-stranded RNA binding [Term] id: CCO:F0005508 name: estrogen response element binding namespace: molecular_function def: "Interacting selectively with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005] synonym: "ERE binding" EXACT [] xref: GO:0034056 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0005509 name: RNA strand-exchange activity namespace: molecular_function def: "Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity." [GOC:mcc, PMID:9769100] xref: GO:0034057 is_a: CCO:F0000310 ! double-stranded RNA binding is_a: CCO:F0000312 ! single-stranded RNA binding [Term] id: CCO:F0005510 name: DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer." [EC:2.7.7.7, GOC:mah] synonym: "deoxynucleate polymerase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid polymerase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase activity" EXACT [EC:2.7.7.7] xref: GO:0034061 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0005511 name: RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [EC:2.7.7.6, GOC:mah] synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleate polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6] synonym: "ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic acid transcriptase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic transcriptase activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "RNA transcriptase activity" EXACT [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: GO:0034062 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0005512 name: aminoglycoside nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside." [GOC:cb] synonym: "aminoglycoside adenylyltransferase activity" NARROW [] synonym: "streptomycin adenylate synthetase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin adenyltransferase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin adenylylase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin-spectinomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] xref: GO:0034068 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0005513 name: aminoglycoside N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside." [GOC:cb] synonym: "kanamycin acetyltransferase activity" NARROW [] xref: GO:0034069 is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0005514 name: aminoglycoside 1-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring." [GOC:cb] xref: GO:0034070 is_a: CCO:F0005513 ! aminoglycoside N-acetyltransferase activity [Term] id: CCO:F0005515 name: aminoglycoside phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside." [GOC:cb, GOC:mah] subset: gosubset_prok synonym: "aminoglycoside kinase activity" EXACT [] xref: EC:2.7.1.119 xref: GO:0034071 xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0005516 name: squalene cyclase activity namespace: molecular_function def: "Catalysis of the reaction: squalene = triterpene." [GOC:cb, PMID:18033581] xref: GO:0034072 is_a: CCO:F0002427 ! cyclase activity [Term] id: CCO:F0005517 name: tetrahymanol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: squalene = tetrahymanol." [ChEBI:9493, GOC:cb, PMID:18033581] xref: GO:0034073 is_a: CCO:F0005516 ! squalene cyclase activity [Term] id: CCO:F0005518 name: marneral synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581] xref: GO:0034074 is_a: CCO:F0004686 ! oxidosqualene cyclase activity [Term] id: CCO:F0005519 name: arabidiol synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene = arabidiol ((3S,13R,14R)-malabarica-17E,21-dien-3beta,14-diol)." [GOC:cb, PMID:18033581] xref: GO:0034075 is_a: CCO:F0004686 ! oxidosqualene cyclase activity [Term] id: CCO:F0005520 name: cucurbitadienol synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene = cucurbitadienol." [GOC:cb, http:/beta.uniprot.org/uniprot/Q6BE24, PMID:18033581] xref: GO:0034076 is_a: CCO:F0004686 ! oxidosqualene cyclase activity [Term] id: CCO:F0005521 name: steryl deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol." [GOC:rb, PMID:18034159] synonym: "sterol deacetylase activity" EXACT [] xref: GO:0034084 is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0005522 name: L-vinylglycine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-vinylglutamate + H2O = alpha-ketobutryrate + NH3." [GOC:ecd, PMID:11470512] comment: Note that this function was formerly EC:4.1.99.4. subset: gosubset_prok synonym: "L-VG deaminase activity" EXACT [EC:3.5.99.7] xref: EC:3.5.99.7 xref: GO:0034100 xref: MetaCyc:4.1.99.4-RXN xref: UM-BBD_enzymeID:e0274 is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0005523 name: apolipoprotein binding namespace: molecular_function def: "Interacting selectively with an apolipoprotein, the protein component of a lipoprotein complex." [GOC:rl] xref: GO:0034185 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005524 name: apolipoprotein A-I binding namespace: molecular_function def: "Interacting selectively with apolipoprotein A-I." [GOC:rl] xref: GO:0034186 is_a: CCO:F0005523 ! apolipoprotein binding [Term] id: CCO:F0005525 name: apolipoprotein E binding namespace: molecular_function def: "Interacting selectively with apolipoprotein E." [GOC:rl] xref: GO:0034187 is_a: CCO:F0005523 ! apolipoprotein binding [Term] id: CCO:F0005526 name: apolipoprotein A-I receptor activity namespace: molecular_function def: "Combining with apolipoprotein A-I to initiate a change in cell activity." [GOC:rl] xref: GO:0034188 is_a: CCO:F0004349 ! apolipoprotein receptor activity is_a: CCO:F0005524 ! apolipoprotein A-I binding [Term] id: CCO:F0005527 name: very-low-density lipoprotein binding namespace: molecular_function def: "Interacting selectively with very-low-density lipoprotein, one of the classes of lipoproteins found in blood plasma in many animals." [GOC:mah] subset: gosubset_prok synonym: "VLDL binding" EXACT [] xref: GO:0034189 is_a: CCO:F0001687 ! lipoprotein binding [Term] id: CCO:F0005528 name: apolipoprotein receptor binding namespace: molecular_function def: "Interacting selectively with an apolipoprotein receptor." [GOC:rl] xref: GO:0034190 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005529 name: apolipoprotein A-I receptor binding namespace: molecular_function def: "Interacting selectively with an apolipoprotein A-I receptor." [GOC:rl] xref: GO:0034191 is_a: CCO:F0005528 ! apolipoprotein receptor binding [Term] id: CCO:F0005530 name: D-heptose 1,7-bisphosphate phosphatase namespace: molecular_function def: "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate." [MetaCyc:RXN0-4361, PMID:11279237] xref: GO:0034200 xref: MetaCyc:RXN0-4361 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0005531 name: glycolipid-translocating activity namespace: molecular_function def: "Catalysis of the movement of glycolipids from one membrane face to the other ('flippase' activity)." [GOC:krc, PMID:11807558] synonym: "flippase activity" BROAD [] xref: GO:0034202 is_a: CCO:F0003557 ! glycolipid transporter activity [Term] id: CCO:F0005532 name: GTP-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of GTP." [GOC:ecd, PMID:17200152] xref: EC:2.7.11.- xref: GO:0034211 xref: Reactome:13522 is_a: CCO:F0001045 ! protein serine/threonine kinase activity [Term] id: CCO:F0005533 name: peptide N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide." [GOC:mah] xref: GO:0034212 is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0005534 name: thiamin:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamin(out) + H+(out) = thiamin(in) + H+(in)." [GOC:mah] synonym: "thiamin:proton symporter activity" EXACT [] synonym: "thiamine:hydrogen symporter activity" EXACT [] synonym: "thiamine:proton symporter activity" EXACT [] xref: GO:0034215 is_a: CCO:F0002744 ! solute:hydrogen symporter activity is_a: CCO:F0002824 ! thiamin uptake transmembrane transporter activity [Term] id: CCO:F0005535 name: high-affinity thiamin:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamin(out) + H+(out) = thiamin(in) + H+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] synonym: "high affinity thiamin:hydrogen symporter activity" EXACT [] synonym: "high-affinity thiamin:proton symporter activity" EXACT [] synonym: "high-affinity thiamine:hydrogen symporter activity" EXACT [] synonym: "high-affinity thiamine:proton symporter activity" EXACT [] xref: GO:0034216 is_a: CCO:F0005534 ! thiamin:hydrogen symporter activity [Term] id: CCO:F0005536 name: ethanolamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ethanolamine from one side of the membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579] subset: gosubset_prok synonym: "2-aminoethanol transmembrane transporter activity" EXACT [] synonym: "ethanolamine permease activity" EXACT [] synonym: "monoethanolamine transmembrane transporter activity" EXACT [] xref: GO:0034228 is_a: CCO:F0001529 ! amine transmembrane transporter activity [Term] id: CCO:F0005537 name: GPI anchor binding namespace: molecular_function def: "Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw] comment: Note that this term should be used to annotate gene products that interact non-covalently with GPI anchors, and not proteins that have GPI anchors covalently attached. synonym: "glycosylphosphatidylinositol binding" EXACT [] xref: GO:0034235 is_a: CCO:F0005562 ! phosphoinositide binding [Term] id: CCO:F0005538 name: protein kinase A catalytic subunit binding namespace: molecular_function def: "Interacting selectively with one or both of the catalytic subunits of protein kinase A." [GOC:mah] synonym: "PKA catalytic subunit binding" EXACT [] xref: GO:0034236 is_a: CCO:F0004210 ! protein kinase binding is_a: CCO:F0008036 ! protein kinase A binding [Term] id: CCO:F0005539 name: protein kinase A regulatory subunit binding namespace: molecular_function def: "Interacting selectively with one or both of the regulatory subunits of protein kinase A." [GOC:mah] synonym: "PKA regulatory subunit binding" EXACT [] synonym: "protein kinase A anchoring activity" RELATED [] xref: GO:0034237 is_a: CCO:F0008036 ! protein kinase A binding [Term] id: CCO:F0005540 name: mitochondrial transcription initiation factor activity namespace: molecular_function def: "A transcription factor activity that confers promoter specificity upon mitochondrial RNA polymerase, in a manner analogous to eubacterial sigma factors." [GOC:mah] synonym: "mitochondrial polymerase transcription factor activity" EXACT [] synonym: "mitochondrial transcription factor activity" RELATED [] xref: GO:0034246 is_a: CCO:F0003499 ! transcription initiation factor activity [Term] id: CCO:F0005541 name: chlorophyll(ide) b reductase activity namespace: molecular_function def: "Catalysis of the reaction: 71-hydroxychlorophyllide a + NAD(P)+ = chlorophyllide b + NAD(P)H + H+." [EC:1.1.1.294, MetaCyc:RXN-7678] synonym: "Chl b reductase activity" EXACT [] synonym: "chlorophyll b reductase activity" EXACT [] synonym: "chlorophyllide b reductase activity" EXACT [] xref: EC:1.1.1.294 xref: GO:0034256 xref: MetaCyc:RXN-7678 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005542 name: nicotinamide riboside transporter activity namespace: molecular_function def: "Catalysis of the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other." [GOC:se] xref: GO:0034257 is_a: CCO:F0001567 ! nucleoside transmembrane transporter activity [Term] id: CCO:F0005543 name: ent-cassa-12,15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate." [MetaCyc:RXN-4881] xref: GO:0034277 xref: MetaCyc:RXN-4881 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005544 name: stemar-13-ene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-syn-copalyl diphosphate = stemar-13-ene + diphosphate." [MetaCyc:RXN-4882] xref: GO:0034278 xref: MetaCyc:RXN-4882 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005545 name: syn-pimara-7,15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-syn-copalyl diphosphate = (-)-9-beta-pimara-7,15-diene + diphosphate." [MetaCyc:RXN-4883] xref: GO:0034279 xref: MetaCyc:RXN-4883 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005546 name: ent-sandaracopimaradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimaradiene + diphosphate." [MetaCyc:RXN-4884] synonym: "ent-pimaradiene synthase activity" BROAD [] xref: GO:0034280 xref: MetaCyc:RXN-4884 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005547 name: ent-isokaurene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate." [PMID:17141283] xref: GO:0034281 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005548 name: ent-pimara-8(14),15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent- pimara-8(14),15-diene + diphosphate." [PMID:17141283] synonym: "ent-pimaradiene synthase activity" BROAD [] xref: GO:0034282 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005549 name: syn-stemod-13(17)-ene synthase activity namespace: molecular_function def: "Catalysis of the reaction: syn-copalyl diphosphate = stemod-13(17)-ene + diphosphate." [PMID:17141283] synonym: "exo-stemodene synthase activity" EXACT [] synonym: "stemod-13(17)-ene synthase activity" EXACT [] synonym: "stemodene synthase activity" EXACT [] synonym: "syn-stemodene synthase activity" EXACT [] xref: GO:0034283 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0005550 name: holin activity namespace: molecular_function def: "Catalysis of the temporally-regulated formation of a transmembrane protein hole that directly or indirectly allows murein hydrolyases to access their cell wall substrate." [GOC:jh2, PMID:1406491] xref: GO:0034290 is_a: CCO:F0002725 ! channel activity [Term] id: CCO:F0005551 name: canonical holin activity namespace: molecular_function def: "Catalysis of the temporally-regulated formation of a non-specific transmembrane protein hole that allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell." [GOC:jh2, GOC:mah, PMID:1406491] xref: GO:0034291 is_a: CCO:F0005550 ! holin activity [Term] id: CCO:F0005552 name: pinholin activity namespace: molecular_function def: "Catalysis of the temporally-regulated formation of a transmembrane protein hole that allows the passage of ions, causing a lethal, irreversible depolarization of the cell membrane." [GOC:jh2, GOC:mah, PMID:1406491] xref: GO:0034292 is_a: CCO:F0005550 ! holin activity [Term] id: CCO:F0005553 name: phosphoinositide 3-kinase activity namespace: molecular_function def: "Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3]." [GOC:bf, PMID:10209156, PMID:9255069] xref: EC:2.7.1.- xref: GO:0035004 is_a: CCO:F0000204 ! lipid kinase activity is_a: CCO:F0000836 ! inositol or phosphatidylinositol kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0005554 name: phosphatidylinositol-4-phosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate." [EC:2.7.1.154, GOC:bf] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.154] synonym: "C2-domain-containing phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.154] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "type II phosphoinositide 3-kinase activity" RELATED [EC:2.7.1.154] xref: EC:2.7.1.154 xref: GO:0035005 xref: MetaCyc:2.7.1.154-RXN is_a: CCO:F0003116 ! phosphatidylinositol phosphate kinase activity is_a: CCO:F0005553 ! phosphoinositide 3-kinase activity [Term] id: CCO:F0005555 name: myosuppressin receptor activity namespace: molecular_function def: "Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf] xref: GO:0035013 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0005556 name: phosphoinositide 3-kinase regulator activity namespace: molecular_function def: "Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069] comment: See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'. synonym: "PI3K regulator activity" EXACT [] xref: GO:0035014 is_a: CCO:F0004130 ! kinase regulator activity [Term] id: CCO:F0005557 name: histone deacetylase regulator activity namespace: molecular_function def: "Modulates the activity of histone deacetylase." [GOC:bf] comment: See also the molecular function term 'histone deacetylase activity ; GO:0004407'. xref: GO:0035033 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0005558 name: histone acetyltransferase regulator activity namespace: molecular_function def: "Modulates the activity of histone acetyltransferase." [GOC:bf] comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "histone acetylase regulator activity" EXACT [] xref: GO:0035034 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0005559 name: histone acetyltransferase binding namespace: molecular_function def: "Interacting selectively with the enzyme histone acetyltransferase." [GOC:bf] synonym: "histone acetylase binding" EXACT [] xref: GO:0035035 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0005560 name: juvenile hormone acid methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf] xref: GO:0035049 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005561 name: methylated histone residue binding namespace: molecular_function def: "Interacting selectively with a methylated residue on a histone protein. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615] xref: GO:0035064 is_a: CCO:F0005669 ! histone binding [Term] id: CCO:F0005562 name: phosphoinositide binding namespace: molecular_function def: "Interacting selectively with any inositol-containing glycerophospholipid." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0035091 is_a: CCO:F0001666 ! phospholipid binding [Term] id: CCO:F0005563 name: ecdysone binding namespace: molecular_function def: "Interacting selectively with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0582227089] xref: GO:0035100 is_a: CCO:F0001634 ! steroid binding is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0005564 name: histone kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] xref: GO:0035173 is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0005565 name: histone serine kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] synonym: "histone-serine kinase activity" EXACT [] xref: GO:0035174 is_a: CCO:F0001045 ! protein serine/threonine kinase activity is_a: CCO:F0005564 ! histone kinase activity [Term] id: CCO:F0005566 name: histone serine kinase activity (H3-S10 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176] synonym: "histone-serine kinase activity (H3-S10 specific)" EXACT [] xref: GO:0035175 is_a: CCO:F0005565 ! histone serine kinase activity [Term] id: CCO:F0005567 name: histone threonine kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] synonym: "histone-threonine kinase activity" EXACT [] xref: GO:0035184 is_a: CCO:F0001045 ! protein serine/threonine kinase activity is_a: CCO:F0005564 ! histone kinase activity [Term] id: CCO:F0005568 name: siRNA binding namespace: molecular_function def: "Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283] synonym: "small interfering RNA binding" EXACT [] xref: GO:0035197 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0005569 name: miRNA binding namespace: molecular_function def: "Interacting selectively with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283] synonym: "microRNA binding" EXACT [] xref: GO:0035198 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0005570 name: glutamate-cysteine ligase catalytic subunit binding namespace: molecular_function def: "Interacting selectively with the catalytic subunit of glutamate-cysteine ligase." [PMID:12954617] xref: GO:0035226 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0005571 name: proctolin receptor activity namespace: molecular_function def: "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf] xref: GO:0035236 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0005572 name: corazonin receptor activity namespace: molecular_function def: "Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf] xref: GO:0035237 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0005573 name: dopamine binding namespace: molecular_function def: "Interacting selectively with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0035240 is_a: CCO:F0005633 ! neurotransmitter binding [Term] id: CCO:F0005574 name: protein-arginine omega-N monomethyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue." [PMID:14705965, RESID:AA0069] xref: GO:0035241 xref: RESID:AA0069 is_a: CCO:F0003096 ! protein-arginine N-methyltransferase activity [Term] id: CCO:F0005575 name: protein-arginine omega-N asymmetric methyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965, RESID:AA0068, RESID:AA0069] comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'. xref: GO:0035242 xref: RESID:AA0068 xref: RESID:AA0069 is_a: CCO:F0003096 ! protein-arginine N-methyltransferase activity [Term] id: CCO:F0005576 name: protein-arginine omega-N symmetric methyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [PMID:14705965, RESID:AA0067, RESID:AA0069] comment: Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'. xref: GO:0035243 xref: RESID:AA0067 xref: RESID:AA0069 is_a: CCO:F0003096 ! protein-arginine N-methyltransferase activity [Term] id: CCO:F0005577 name: peptidyl-arginine C-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein." [GOC:bf] xref: GO:0035244 is_a: CCO:F0001756 ! C-methyltransferase activity is_a: CCO:F0001813 ! protein methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0005578 name: alpha-1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086] synonym: "alpha-1,4-GalNAc transferase activity" EXACT [] xref: GO:0035248 is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0005579 name: UDP-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] subset: gosubset_prok xref: GO:0035250 is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0001853 ! galactosyltransferase activity [Term] id: CCO:F0005580 name: UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] subset: gosubset_prok xref: GO:0035251 is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005581 name: UDP-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] xref: GO:0035252 is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0005645 ! xylosyltransferase activity [Term] id: CCO:F0005582 name: glutamate receptor binding namespace: molecular_function def: "Interacting selectively with a glutamate receptor." [GOC:bf] xref: GO:0035254 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005583 name: ionotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0035255 is_a: CCO:F0005582 ! glutamate receptor binding [Term] id: CCO:F0005584 name: metabotropic glutatmate receptor binding namespace: molecular_function def: "Interacting selectively with a metabotropic glutamate receptor. Metabotropic glutamate receptors are G-protein coupled receptors that bind glutamate and exert an effect through the regulation of enzyme activity." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:9069287] xref: GO:0035256 is_a: CCO:F0000196 ! G-protein-coupled receptor binding is_a: CCO:F0005582 ! glutamate receptor binding [Term] id: CCO:F0005585 name: nuclear hormone receptor binding namespace: molecular_function def: "Interacting selectively with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell." [GOC:bf] xref: GO:0035257 is_a: CCO:F0008109 ! hormone receptor binding [Term] id: CCO:F0005586 name: steroid hormone receptor binding namespace: molecular_function def: "Interacting selectively with a steroid hormone receptor." [GOC:bf] xref: GO:0035258 is_a: CCO:F0005585 ! nuclear hormone receptor binding [Term] id: CCO:F0005587 name: glucocorticoid receptor binding namespace: molecular_function def: "Interacting selectively with a glucocorticoid receptor." [GOC:bf] xref: GO:0035259 is_a: CCO:F0005586 ! steroid hormone receptor binding [Term] id: CCO:F0005588 name: phthalate binding namespace: molecular_function def: "Interacting selectively with a phthalate, any ester or salt of phthalic acid." [http://umbbd.ahc.umn.edu/pth/pth_map.html] subset: goslim_pir subset: gosubset_prok xref: GO:0035273 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005589 name: diphenyl phthalate binding namespace: molecular_function def: "Interacting selectively with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com] synonym: "DPP binding" EXACT [] xref: GO:0035274 is_a: CCO:F0005588 ! phthalate binding [Term] id: CCO:F0005590 name: dibutyl phthalate binding namespace: molecular_function def: "Interacting selectively with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com] synonym: "DBP binding" EXACT [] synonym: "phthalic acid dibutyl ester binding" EXACT [] xref: GO:0035275 is_a: CCO:F0005588 ! phthalate binding [Term] id: CCO:F0005591 name: ethanol binding namespace: molecular_function def: "Interacting selectively with ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0035276 is_a: CCO:F0005812 ! alcohol binding [Term] id: CCO:F0005592 name: inositol pentakisphosphate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate." [EC:2.7.1.158] synonym: "ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.158] synonym: "Gsl1p" RELATED [EC:2.7.1.158] synonym: "inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "inositol polyphosphate kinase activity" EXACT [EC:2.7.1.158] synonym: "inositol-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "Ins(1,3,4,5,6)P5 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "IP5 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "Ipk1p" RELATED [EC:2.7.1.158] xref: EC:2.7.1.158 xref: GO:0035299 is_a: CCO:F0000836 ! inositol or phosphatidylinositol kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0005593 name: inositol-1,3,4-trisphosphate 5/6-kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate." [EC:2.7.1.159, PMID:9126335] synonym: "ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.159] synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" NARROW [] synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" NARROW [] synonym: "inositol trisphosphate 5/6-kinase activity" EXACT [EC:2.7.1.159] synonym: "Ins(1,3,4)P3 5/6-kinase activity" EXACT [EC:2.7.1.159] synonym: "IP56K" RELATED [EC:2.7.1.159] xref: EC:2.7.1.159 xref: GO:0035300 xref: MetaCyc:2.7.1.133-RXN is_a: CCO:F0008191 ! inositol trisphosphate kinase activity [Term] id: CCO:F0005594 name: ecdysteroid 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:15350618] comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol). xref: GO:0035302 is_a: CCO:F0001866 ! steroid hydroxylase activity [Term] id: CCO:F0005595 name: 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684] xref: GO:0035312 is_a: CCO:F0001876 ! 5'-3' exonuclease activity is_a: CCO:F0003453 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005596 name: interleukin-18 binding namespace: molecular_function def: "Interacting selectively with interleukin-18." [GOC:jl] synonym: "IL-18 binding" EXACT [] xref: GO:0042007 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0005597 name: interleukin-18 receptor activity namespace: molecular_function def: "Combining with interleukin-18 to initiate a change in cell activity." [GOC:jl] synonym: "IL-18R" EXACT [] xref: GO:0042008 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0005596 ! interleukin-18 binding [Term] id: CCO:F0005598 name: interleukin-15 binding namespace: molecular_function def: "Interacting selectively with interleukin-15." [GOC:jl] synonym: "IL-15 binding" EXACT [] xref: GO:0042009 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0005599 name: interleukin-15 receptor activity namespace: molecular_function def: "Combining with interleukin-15 to initiate a change in cell activity." [GOC:jl] synonym: "IL-15R" EXACT [] xref: GO:0042010 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0005598 ! interleukin-15 binding [Term] id: CCO:F0005600 name: interleukin-16 binding namespace: molecular_function def: "Interacting selectively with interleukin-16." [GOC:jl] synonym: "IL-16 binding" EXACT [] xref: GO:0042011 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0005601 name: interleukin-16 receptor activity namespace: molecular_function def: "Combining with interleukin-16 to initiate a change in cell activity." [GOC:jl] synonym: "IL-16R" EXACT [] xref: GO:0042012 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0005600 ! interleukin-16 binding [Term] id: CCO:F0005602 name: interleukin-19 binding namespace: molecular_function def: "Interacting selectively with interleukin-19." [GOC:jl] synonym: "IL-19 binding" EXACT [] xref: GO:0042013 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0005603 name: interleukin-19 receptor activity namespace: molecular_function def: "Combining with interleukin-19 to initiate a change in cell activity." [GOC:jl] synonym: "IL-19R" EXACT [] xref: GO:0042014 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0005602 ! interleukin-19 binding [Term] id: CCO:F0005604 name: interleukin-20 binding namespace: molecular_function def: "Interacting selectively with interleukin-20." [GOC:jl] synonym: "IL-20 binding" EXACT [] xref: GO:0042015 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0005605 name: interleukin-20 receptor activity namespace: molecular_function def: "Combining with interleukin-20 to initiate a change in cell activity." [GOC:jl] synonym: "IL-20R" EXACT [] xref: GO:0042016 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0005604 ! interleukin-20 binding [Term] id: CCO:F0005606 name: interleukin-22 binding namespace: molecular_function def: "Interacting selectively with interleukin-22." [GOC:jl] synonym: "IL-22 binding" EXACT [] xref: GO:0042017 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0005607 name: interleukin-22 receptor activity namespace: molecular_function def: "Combining with interleukin-22 to initiate a change in cell activity." [GOC:jl] synonym: "IL-22R" EXACT [] xref: GO:0042018 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0005606 ! interleukin-22 binding [Term] id: CCO:F0005608 name: interleukin-23 binding namespace: molecular_function def: "Interacting selectively with interleukin-23." [GOC:jl] synonym: "IL-23 binding" EXACT [] xref: GO:0042019 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0005609 name: interleukin-23 receptor activity namespace: molecular_function def: "Combining with interleukin-23 to initiate a change in cell activity." [GOC:jl] synonym: "IL-23R" EXACT [] xref: GO:0042020 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0005608 ! interleukin-23 binding [Term] id: CCO:F0005610 name: granulocyte macrophage colony-stimulating factor complex binding namespace: molecular_function def: "Interacting selectively with the granulocyte macrophage colony-stimulating factor complex." [GOC:ai] synonym: "GM-CSF complex binding" EXACT [] synonym: "GMC-SF complex binding" EXACT [] xref: GO:0042021 is_a: CCO:F0004221 ! cytokine binding [Term] id: CCO:F0005611 name: juglone-sensitive peptidyl-prolyl cis-trans isomerase activity namespace: molecular_function synonym: "juglone-sensitive cis-trans proline isomerase activity" EXACT [] xref: EC:5.2.1.- xref: GO:0042028 is_a: CCO:F0000319 ! peptidyl-prolyl cis-trans isomerase activity [Term] id: CCO:F0005612 name: fibrolase activity namespace: molecular_function def: "Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [EC:3.4.24.72, PMID:7725320] synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [EC:3.4.24.72] synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [EC:3.4.24.72] synonym: "fibrinolytic proteinase activity" EXACT [EC:3.4.24.72] xref: EC:3.4.24.72 xref: GO:0042029 xref: MetaCyc:3.4.24.72-RXN is_a: CCO:F0000676 ! metalloendopeptidase activity [Term] id: CCO:F0005613 name: ATPase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate." [GOC:jl] synonym: "adenosinetriphosphatase inhibitor" EXACT [] xref: GO:0042030 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0005614 name: angiotensin-converting enzyme inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I." [GOC:jl] synonym: "ACE inhibitor" EXACT [] synonym: "peptidyl dipeptidase A inhibitor" EXACT [] xref: GO:0042031 is_a: CCO:F0004441 ! protease inhibitor activity [Term] id: CCO:F0005615 name: neurexin binding namespace: molecular_function def: "Interacting selectively with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [http://cancerweb.ncl.ac.uk/] synonym: "neuroligin" RELATED [] xref: GO:0019963 xref: GO:0042043 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005616 name: histone methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group (CH3-) to a histone." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0042054 is_a: CCO:F0001813 ! protein methyltransferase activity [Term] id: CCO:F0005617 name: chemoattractant activity namespace: molecular_function def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "attractant" BROAD [] xref: GO:0042056 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0005618 name: leucokinin receptor activity namespace: molecular_function def: "Combining with a leucokinin, any of several octapeptide hormones found in insects, to initiate a change in cell activity." [GOC:mah, PMID:2716741] xref: GO:0042071 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0005619 name: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate." [GOC:ai] subset: gosubset_prok xref: GO:0042083 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005620 name: 5-methyltetrahydrofolate-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate." [GOC:ai] subset: gosubset_prok xref: GO:0042084 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005621 name: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate." [GOC:ai] subset: gosubset_prok xref: GO:0042085 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005622 name: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin." [GOC:ai] subset: gosubset_prok xref: GO:0042086 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005623 name: glucanosyltransferase activity namespace: molecular_function def: "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation." [GOC:jl] xref: GO:0042123 is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0005624 name: 1,3-beta-glucanosyltransferase activity namespace: molecular_function def: "Catalysis of the splitting and linkage of 1,3-beta-glucan molecules, resulting in 1,3-beta-glucan chain elongation." [GOC:jl, PMID:10809732] xref: GO:0042124 is_a: CCO:F0005623 ! glucanosyltransferase activity [Term] id: CCO:F0005625 name: thiamin phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of thiamin phosphate." [PMID:197075] synonym: "thiamine phosphate phosphatase activity" EXACT [] xref: GO:0042131 is_a: CCO:F0000478 ! acid phosphatase activity [Term] id: CCO:F0005626 name: fructose-bisphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11] subset: gosubset_prok synonym: "D-fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "D-fructose-1,6-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.11] synonym: "D-fructose-1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "FBPase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-bisphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-bisphosphate 1-phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-diphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose diphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose-1,6-bisphosphatase activity" EXACT [EC:3.1.3.11] synonym: "hexose bisphosphatase activity" EXACT [EC:3.1.3.11] synonym: "hexose diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "hexosediphosphatase activity" BROAD [EC:3.1.3.11] xref: EC:3.1.3.11 xref: GO:0042132 xref: MetaCyc:F16BDEPHOS-RXN xref: Reactome:9272 is_a: CCO:F0004126 ! carbohydrate phosphatase activity [Term] id: CCO:F0005627 name: rRNA primary transcript binding namespace: molecular_function def: "Interacting selectively with an unprocessed ribosomal RNA transcript." [GOC:jl] xref: GO:0042134 is_a: CCO:F0004192 ! rRNA binding [Term] id: CCO:F0005628 name: RPTP-like protein binding namespace: molecular_function def: "Interacting selectively with proteins with similar structure/function to receptor protein tyrosine phosphatases." [GOC:jl] synonym: "receptor protein tyrosine phosphatase-like protein binding" EXACT [] xref: GO:0042153 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005629 name: zinc-mediated transcriptional activator activity namespace: molecular_function def: "Initiates or upregulates transcription in the presence of zinc." [GOC:jl] xref: GO:0042156 is_a: CCO:F0003205 ! transcription activator activity [Term] id: CCO:F0005630 name: telomeric DNA binding namespace: molecular_function def: "Interacting selectively with telomere-associated DNA, usually characterized by highly repetitive sequences." [GOC:jl, ISBN:0321000382] synonym: "telomere binding" BROAD [] xref: GO:0042162 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0005631 name: interleukin-12 beta subunit binding namespace: molecular_function def: "Interacting selectively with the beta subunit of interleukin-12." [GOC:mah] synonym: "CLMFp40 binding" EXACT [] synonym: "IL-12B binding" EXACT [] synonym: "IL-12p40 binding" EXACT [] synonym: "NKSFp40 binding" EXACT [] xref: GO:0042163 is_a: CCO:F0004236 ! interleukin-12 binding [Term] id: CCO:F0005632 name: interleukin-12 alpha subunit binding namespace: molecular_function def: "Interacting selectively with the alpha subunit of interleukin-12." [GOC:mah] synonym: "CLMFp35 binding" EXACT [] synonym: "IL-12A binding" EXACT [] synonym: "IL-12p35 binding" EXACT [] synonym: "NKSFp35 binding" EXACT [] xref: GO:0042164 is_a: CCO:F0004236 ! interleukin-12 binding [Term] id: CCO:F0005633 name: neurotransmitter binding namespace: molecular_function def: "Interacting selectively with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir xref: GO:0042165 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005634 name: acetylcholine binding namespace: molecular_function def: "Interacting selectively with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] xref: GO:0042166 is_a: CCO:F0005633 ! neurotransmitter binding is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0005635 name: SH2 domain binding namespace: molecular_function def: "Interacting selectively with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017] xref: GO:0042169 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0005636 name: lysophosphatidic acid acyltransferase activity namespace: molecular_function xref: GO:0042171 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0005637 name: cobyrinic acid a,c-diamide synthase activity namespace: molecular_function def: "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide." [PMID:2172209] comment: Note that this enzyme does not have an EC number yet, as its activity has not been proven experimentally. May need to be moved in the future. subset: gosubset_prok synonym: "CobB" NARROW [] xref: GO:0042242 is_a: CCO:F0000778 ! glutaminase activity [Term] id: CCO:F0005638 name: neuropeptide F receptor activity namespace: molecular_function def: "Combining with neuropeptide F, an invertebrate neuropeptide thought to play a role in neuroregulation, to initiate a change in cell activity. In many species, neuropeptide F is between 36 and 39 amino acid residues terminating in a phenylalaninamide residue." [GOC:ma] xref: GO:0042263 is_a: CCO:F0001769 ! neuropeptide receptor activity [Term] id: CCO:F0005639 name: peptide binding namespace: molecular_function def: "Interacting selectively with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl] subset: goslim_pir subset: gosubset_prok xref: GO:0042277 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005640 name: nitrite reductase (cytochrome, ammonia-forming) activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = NO2(-) (nitrite) + 6 ferrocytochrome c + 7 H+." [EC:1.7.2.2] subset: gosubset_prok synonym: "ammonia:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.2] synonym: "cytochrome c nitrite reductase activity" EXACT [] synonym: "cytochrome c552 activity" NARROW [EC:1.7.2.2] synonym: "multiheme nitrite reductase activity" EXACT [] synonym: "nitrite reductase (cytochrome; ammonia-forming)" EXACT [EC:1.7.2.2] xref: EC:1.7.2.2 xref: GO:0042279 xref: MetaCyc:1.7.2.2-RXN is_a: CCO:F0003257 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: CCO:F0005641 name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [UniProtKB:Q9VKX7] synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: EC:2.4.1.- xref: GO:0042281 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005642 name: hydroxymethylglutaryl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+." [EC:1.1.1.88] subset: gosubset_prok synonym: "(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.1.1.88] synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase activity" EXACT [EC:1.1.1.88] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.88] synonym: "beta-hydroxy-beta-methylglutaryl CoA-reductase activity" BROAD [EC:1.1.1.88] synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.88] synonym: "hydroxymethylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] synonym: "hydroxymethylglutaryl-CoA reductase (NADH) activity" EXACT [EC:1.1.1.88] xref: EC:1.1.1.88 xref: GO:0042282 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005643 name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [UniProtKB:Q9W3V8] synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: EC:2.4.1.- xref: GO:0042283 is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0005644 name: sphingolipid delta-4 desaturase activity namespace: molecular_function def: "Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid." [PMID:12417141] synonym: "delta-4 sphingolipid desaturase activity" EXACT [] xref: GO:0042284 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0005645 name: xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] xref: GO:0042285 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0005646 name: glutamate-1-semialdehyde 2,1-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate." [EC:5.4.3.8] subset: gosubset_prok synonym: "(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity" EXACT [EC:5.4.3.8] synonym: "glutamate-1-semialdehyde aminotransferase activity" EXACT [EC:5.4.3.8] xref: EC:5.4.3.8 xref: GO:0042286 xref: MetaCyc:GSAAMINOTRANS-RXN is_a: CCO:F0003430 ! intramolecular transferase activity, transferring amino groups [Term] id: CCO:F0005647 name: MHC protein binding namespace: molecular_function def: "Interacting selectively with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "major histocompatibility complex binding" EXACT [] synonym: "major histocompatibility complex ligand" NARROW [] xref: GO:0042287 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005648 name: MHC class I protein binding namespace: molecular_function def: "Interacting selectively with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "major histocompatibility complex class I binding" EXACT [] synonym: "major histocompatibility complex class I ligand" NARROW [] synonym: "T cell receptor activity" RELATED [] xref: GO:0042288 is_a: CCO:F0005647 ! MHC protein binding [Term] id: CCO:F0005649 name: MHC class II protein binding namespace: molecular_function def: "Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "major histocompatibility complex class II binding" EXACT [] synonym: "major histocompatibility complex class II ligand" NARROW [] xref: GO:0042289 is_a: CCO:F0005647 ! MHC protein binding [Term] id: CCO:F0005650 name: URM1 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] xref: GO:0042292 is_a: CCO:F0002013 ! small protein activating enzyme activity [Term] id: CCO:F0005651 name: Hub1 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] xref: GO:0042293 is_a: CCO:F0002013 ! small protein activating enzyme activity [Term] id: CCO:F0005652 name: URM1 conjugating enzyme activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein URM1 to other proteins or other substrate molecules." [GOC:mah, PMID:12826404] xref: GO:0042294 is_a: CCO:F0004170 ! small conjugating protein ligase activity [Term] id: CCO:F0005654 name: lupeol synthase activity namespace: molecular_function def: "Catalysis of the cyclization of (S)-2,3-oxidosqualene to lupeol." [PMID:9883589] synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99.- xref: GO:0042299 xref: MetaCyc:PWY-112 is_a: CCO:F0004686 ! oxidosqualene cyclase activity [Term] id: CCO:F0005655 name: beta-amyrin synthase activity namespace: molecular_function def: "Catalysis of the cyclization and rearrangement of 2,3-oxidosqualene into beta-amyrin." [PMID:9746369] synonym: "oxidosqualene:beta-amyrin cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99.- xref: GO:0042300 is_a: CCO:F0004686 ! oxidosqualene cyclase activity [Term] id: CCO:F0005656 name: phosphate binding namespace: molecular_function def: "Interacting selectively with phosphate." [GOC:jl] subset: gosubset_prok xref: GO:0042301 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005657 name: structural constituent of cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] xref: GO:0042302 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0005658 name: bacteriochlorophyll binding namespace: molecular_function def: "Interacting selectively with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants." [ISBN:0192800981] subset: gosubset_prok xref: GO:0042314 is_a: CCO:F0003059 ! chlorophyll binding [Term] id: CCO:F0005659 name: cytosol nonspecific dipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [EC:3.4.13.18] comment: Note that this function was formerly EC:3.4.3.1, EC:3.4.3.2, EC:3.4.3.6, EC:3.4.13.1, EC:3.4.13.2, EC:3.4.13.8, EC:3.4.13.11 and EC:3.4.13.15. subset: gosubset_prok synonym: "cytosol non-specific dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "diglycinase activity" EXACT [EC:3.4.13.18] synonym: "Gly-Leu hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-glycine dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "glycyl-L-leucine dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-L-leucine hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-L-leucine peptidase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-leucine dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "glycylleucine dipeptide hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycylleucine hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycylleucine peptidase activity" EXACT [EC:3.4.13.18] synonym: "human cytosolic non-specific dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "iminodipeptidase activity" EXACT [EC:3.4.13.18] synonym: "L-amino-acyl-L-amino-acid hydrolase activity" EXACT [EC:3.4.13.18] synonym: "L-prolylglycine dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "N(2)-beta-alanylarginine dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "N2-beta-alanylarginine dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "non-specific dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "peptidase A activity" BROAD [EC:3.4.13.18] synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "prolinase activity" NARROW [EC:3.4.13.18] synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18] xref: EC:3.4.13.18 xref: GO:0042315 xref: MetaCyc:3.4.13.18-RXN is_a: CCO:F0003375 ! dipeptidase activity [Term] id: CCO:F0005660 name: hypocretin receptor binding namespace: molecular_function def: "Interacting selectively with the hypocretin receptor." [GOC:ceb, PMID:11988773] synonym: "hypocretin receptor ligand" NARROW [] synonym: "orexin receptor binding" EXACT [] synonym: "orexin receptor ligand" NARROW [] xref: GO:0042324 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0005661 name: heparan sulfate N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate." [GOC:ma] synonym: "heparan sulphate N-acetylglucosaminyltransferase activity" EXACT [] xref: GO:0042328 is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0005662 name: structural constituent of collagen and cuticulin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle." [GOC:jl, GOC:mtg_sensu] synonym: "structural constituent of cuticle (sensu Nematoda)" EXACT [] xref: GO:0042329 is_a: CCO:F0005657 ! structural constituent of cuticle [Term] id: CCO:F0005663 name: guiding stereospecific synthesis activity namespace: molecular_function def: "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis." [GOC:ma] synonym: "dirigent protein" NARROW [] xref: GO:0042349 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0005664 name: GDP-4-dehydro-D-rhamnose reductase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed." [BRENDA:1.1.1.187, EC:1.1.1.187] subset: gosubset_prok synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" EXACT [EC:1.1.1.187] synonym: "GDP-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187] synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.187] synonym: "guanosine diphosphate-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187] xref: EC:1.1.1.187 xref: GO:0042356 xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005665 name: chemokine receptor binding namespace: molecular_function def: "Interacting selectively with any chemokine receptor." [GOC:ai] synonym: "chemokine receptor ligand" NARROW [] xref: GO:0042379 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0005666 name: hydroxymethylbutenyl pyrophosphate reductase activity namespace: molecular_function def: "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate." [GOC:js] comment: Note that the enzyme performing this function has only recently been characterized, and not completely (see PMID:11818558). The common and systematic names have been suggested by TIGR, who have recently compiled an HMM model for this gene (TIGR00216). The enzyme appears to catalyze the final step in the non-mevalonate terpene biosynthesis pathway. Its two products, isopentenyl pyrophosphate and dimethylallyl pyrophosphate, are apparently generated from a common intermediate formed by the enzyme. The mechanism and identity of the reductant have not yet been determined. subset: gosubset_prok synonym: "(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)" EXACT [] xref: GO:0042380 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0005667 name: omega-3 fatty acid desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain." [GOC:jl, PMID:9037020] xref: EC:1.14.99.- xref: GO:0042389 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0005668 name: sphingosine-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:11331102] synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT [] synonym: "SPP phosphatase activity" EXACT [] synonym: "SPPase activity" EXACT [] xref: GO:0042392 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0005669 name: histone binding namespace: molecular_function def: "Interacting selectively with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] synonym: "histone-specific chaperone activity" RELATED [] xref: GO:0042393 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005670 name: myrcene/(E)-beta-ocimene synthase activity namespace: molecular_function def: "Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes." [GOC:cr, PMID:10700382] synonym: "myrcene/ocimene synthase activity" EXACT [] xref: EC:4.6.-.- xref: GO:0042408 is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003413 ! phosphorus-oxygen lyase activity [Term] id: CCO:F0005671 name: caffeoyl-CoA O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104] subset: gosubset_prok synonym: "caffeoyl coenzyme A methyltransferase activity" EXACT [] synonym: "caffeoyl-CoA 3-O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104] synonym: "trans-caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104] xref: EC:2.1.1.104 xref: GO:0042409 xref: MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0005672 name: 6-carboxyhexanoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA." [EC:6.2.1.14] subset: gosubset_prok synonym: "6-carboxyhexanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.14] synonym: "6-carboxyhexanoyl-CoA synthetase activity" EXACT [EC:6.2.1.14] synonym: "pimeloyl-CoA synthetase activity" EXACT [EC:6.2.1.14] synonym: "pimelyl-CoA synthetase activity" EXACT [EC:6.2.1.14] xref: EC:6.2.1.14 xref: GO:0042410 xref: MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0005673 name: beta-carotene hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of both beta rings of beta-carotene to form zeaxanthine." [GOC:cr] xref: GO:0042411 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0005674 name: versicolorin reductase activity namespace: molecular_function def: "Catalysis of the reduction of versicolorin A to sterigmatocystin." [UniProtKB:P50161] xref: EC:1.1.-.- xref: GO:0042469 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0005675 name: triacylated lipoprotein binding namespace: molecular_function def: "Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a three acyl groups." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0042497 is_a: CCO:F0001687 ! lipoprotein binding [Term] id: CCO:F0005676 name: diacylated lipoprotein binding namespace: molecular_function def: "Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a two acyl groups." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0042498 is_a: CCO:F0001687 ! lipoprotein binding [Term] id: CCO:F0005677 name: signal peptide peptidase activity namespace: molecular_function def: "Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416] comment: Note that this function is distinct from the 'signal peptidases' (see the molecular function term 'signal peptidase activity ; GO:0009003' and its children). Broadly, signal peptidases cleave N-terminal leader sequences from secreted or membrane proteins, thereby creating signal peptides, while signal peptide peptidases cleave the signal peptides themselves. synonym: "SPP" EXACT [] xref: EC:3.4.23.- xref: GO:0042499 is_a: CCO:F0005678 ! aspartic endopeptidase activity, intramembrane cleaving [Term] id: CCO:F0005678 name: aspartic endopeptidase activity, intramembrane cleaving namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases. xref: EC:3.4.23.- xref: GO:0042500 is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0005679 name: eukaryotic elongation factor-2 kinase regulator activity namespace: molecular_function def: "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] synonym: "eEF-2 kinase regulator" EXACT [] xref: EC:2.7.1.- xref: GO:0042556 is_a: CCO:F0004204 ! protein kinase regulator activity [Term] id: CCO:F0005680 name: eukaryotic elongation factor-2 kinase activator activity namespace: molecular_function def: "Increases the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] synonym: "eEF-2 kinase activator" EXACT [] xref: EC:2.7.1.- xref: GO:0042557 is_a: CCO:F0004382 ! protein kinase activator activity is_a: CCO:F0005679 ! eukaryotic elongation factor-2 kinase regulator activity [Term] id: CCO:F0005681 name: alpha-amyrin synthase activity namespace: molecular_function def: "Catalysis of the cyclization and rearrangement of 2,3-oxidosqualene into alpha-amyrin." [GOC:jl, PMID:10848960] xref: GO:0042561 xref: MetaCyc:PWY-5377 is_a: CCO:F0004686 ! oxidosqualene cyclase activity [Term] id: CCO:F0005682 name: hormone binding namespace: molecular_function def: "Interacting selectively with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: goslim_pir xref: GO:0042562 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005683 name: aspartyl aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21] subset: gosubset_prok xref: EC:3.4.11.21 xref: GO:0042576 xref: MetaCyc:3.4.11.21-RXN is_a: CCO:F0000646 ! aminopeptidase activity [Term] id: CCO:F0005684 name: lipid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl] xref: GO:0042577 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0005685 name: phosphoric ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] subset: gosubset_prok xref: EC:3.1.-.- xref: GO:0042578 is_a: CCO:F0003360 ! hydrolase activity, acting on ester bonds [Term] id: CCO:F0005686 name: peptide deformylase activity namespace: molecular_function def: "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl] subset: gosubset_prok synonym: "formyl-L-methionyl peptide amidohydrolase activity" EXACT [EC:3.5.1.88] synonym: "PDF activity" EXACT [EC:3.5.1.88] synonym: "polypeptide deformylase activity" EXACT [EC:3.5.1.88] xref: EC:3.5.1.88 xref: GO:0042586 xref: MetaCyc:3.5.1.88-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005687 name: flavin reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + H+." [EC:1.5.1.30] subset: gosubset_prok synonym: "FMN reductase (NADPH) activity" EXACT [EC:1.5.1.30] synonym: "NADPH dehydrogenase (flavin) activity" EXACT [EC:1.5.1.30] synonym: "NADPH-dependent FMN reductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH-flavin oxidoreductase activity" EXACT [] synonym: "NADPH-flavin reductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH-FMN reductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH-specific FMN reductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH2 dehydrogenase (flavin)" EXACT [EC:1.5.1.30] synonym: "NADPH2:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH:flavin oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "reduced-riboflavin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.30] synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.30] synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.30] xref: EC:1.5.1.30 xref: GO:0042602 xref: MetaCyc:NADPH-DEHYDROGENASE-(FLAVIN)-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005688 name: peptide antigen binding namespace: molecular_function def: "Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jl] comment: Note that this term can be used to describe binding to the peptide expressed by an MHC molecule. xref: GO:0042605 is_a: CCO:F0000342 ! antigen binding is_a: CCO:F0005639 ! peptide binding [Term] id: CCO:F0005689 name: endogenous peptide antigen binding namespace: molecular_function def: "Interacting selectively with an antigen peptide, a fragment of an endogenous foreign protein, derived by proteolysis within the cell." [GOC:jl] comment: Note that this term can be used to describe binding to the peptide expressed by an MHC molecule. xref: GO:0042606 is_a: CCO:F0005688 ! peptide antigen binding [Term] id: CCO:F0005690 name: exogenous peptide antigen binding namespace: molecular_function def: "Interacting selectively with an antigen peptide, a fragment of an exogenous foreign protein derived by endocytosis of the protein and proteolysis within the cell." [GOC:jl] comment: Note that this term can be used to describe binding to the peptide expressed by an MHC molecule. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] xref: GO:0042607 is_a: CCO:F0005688 ! peptide antigen binding [Term] id: CCO:F0005691 name: T cell receptor binding namespace: molecular_function def: "Interacting selectively with a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "T lymphocyte receptor binding" EXACT [] synonym: "T-cell receptor binding" EXACT [] synonym: "T-lymphocyte receptor binding" EXACT [] synonym: "TCR binding" EXACT [] xref: GO:0042608 is_a: CCO:F0001407 ! receptor binding is_a: CCO:F0004983 ! protein complex binding [Term] id: CCO:F0005692 name: CD4 receptor binding namespace: molecular_function def: "Interacting selectively with a CD4, a receptor found on the surface of T cells, monocytes and macrophages." [GOC:jl, MeSH:D015704] xref: GO:0042609 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005693 name: CD8 receptor binding namespace: molecular_function def: "Interacting selectively with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes." [GOC:jl, MeSH:D016827] xref: GO:0042610 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005694 name: CD70 receptor binding namespace: molecular_function def: "Interacting selectively with a CD70, a receptor found on the surface of most activated B cells and some activated T cells." [GOC:jl, ISBN:0120781859] synonym: "CD27 receptor activity" RELATED [] synonym: "CD27L binding" EXACT [] xref: GO:0042614 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005695 name: CD154 receptor binding namespace: molecular_function def: "Interacting selectively with CD154, a receptor found on the surface of some activated lymphocytes." [GOC:jl, ISBN:0120781859] synonym: "CD40 receptor activity" RELATED [] synonym: "CD40L binding" EXACT [] xref: GO:0042615 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005696 name: ATPase activity, coupled namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (polypeptide-unfolding)" NARROW [EC:3.6.4.9] synonym: "chaperonin" RELATED [EC:3.6.4.9] synonym: "chaperonin ATPase activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "nucleoplasmin ATPase activity" RELATED [] synonym: "peroxisome-assembly ATPase activity" RELATED [] xref: GO:0042623 is_a: CCO:F0003445 ! ATPase activity [Term] id: CCO:F0005697 name: ATPase activity, uncoupled namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; not directly coupled to any other reaction." [EC:3.6.1.3] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "adenylpyrophosphatase activity" RELATED [EC:3.6.1.3] xref: EC:3.6.1.3 xref: GO:0042624 xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN is_a: CCO:F0003445 ! ATPase activity [Term] id: CCO:F0005698 name: ATPase activity, coupled to transmembrane movement of ions namespace: molecular_function def: "Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [EC:3.6.1.3, GOC:def, GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0042625 is_a: CCO:F0002557 ! ion transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0005699 name: ATPase activity, coupled to transmembrane movement of substances namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ABC transporter" NARROW [] synonym: "ABC-type efflux permease activity" NARROW [] synonym: "ABC-type efflux porter activity" NARROW [] synonym: "ABC-type uptake permease activity" NARROW [] synonym: "ATP binding cassette transporter" NARROW [] synonym: "ATP-binding cassette (ABC) transporter activity" NARROW [] synonym: "ATP-binding cassette transporter" NARROW [] synonym: "mating pheromone exporter" NARROW [] xref: GO:0042626 is_a: CCO:F0002826 ! P-P-bond-hydrolysis-driven transmembrane transporter activity is_a: CCO:F0003388 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances is_a: CCO:F0005860 ! ATPase activity, coupled to movement of substances [Term] id: CCO:F0005700 name: ecdysis-triggering hormone receptor activity namespace: molecular_function def: "Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma] synonym: "ecdysis-triggering hormone binding" NARROW [] synonym: "ETH receptor" EXACT [] xref: GO:0042654 is_a: CCO:F0001272 ! G-protein coupled receptor activity is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0005701 name: JUN kinase kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)." [GOC:bf] synonym: "JUNKKKK activity" EXACT [] xref: GO:0042656 is_a: CCO:F0001845 ! MAP kinase kinase kinase kinase activity [Term] id: CCO:F0005702 name: MHC class II protein binding, via lateral surface namespace: molecular_function def: "Interacting selectively with the lateral surface of major histocompatibility complex class II molecules." [GOC:jl] synonym: "major histocompatibility complex class II protein binding, via lateral surface" EXACT [] xref: GO:0042657 is_a: CCO:F0005649 ! MHC class II protein binding [Term] id: CCO:F0005703 name: MHC class II protein binding, via antigen binding groove namespace: molecular_function def: "Interacting selectively with the antigen binding groove of major histocompatibility complex class II molecules." [GOC:jl] synonym: "major histocompatibility complex class II protein binding, via antigen binding groove" EXACT [] xref: GO:0042658 is_a: CCO:F0005649 ! MHC class II protein binding [Term] id: CCO:F0005704 name: elastase activity namespace: molecular_function def: "Catalysis of the hydrolysis of elastin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0042708 is_a: CCO:F0000644 ! endopeptidase activity [Term] id: CCO:F0005705 name: PH domain binding namespace: molecular_function def: "Interacting selectively with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton." [GOC:jl, Pfam:PF00169] xref: GO:0042731 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0005706 name: NADH kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NADH = ADP + NADPH." [PMID:12727869] synonym: "ATP:NADH 2'-phosphotransferase activity" EXACT [EC:2.7.1.86] synonym: "DPNH kinase activity" EXACT [EC:2.7.1.86] synonym: "reduced diphosphopyridine nucleotide kinase activity" EXACT [EC:2.7.1.86] synonym: "reduced nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.86] xref: EC:2.7.1.86 xref: GO:0042736 xref: MetaCyc:NADH-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0005707 name: ecdysteroid 22-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427] comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone. xref: GO:0042767 is_a: CCO:F0001866 ! steroid hydroxylase activity [Term] id: CCO:F0005708 name: ecdysteroid 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427] comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone. xref: GO:0042768 is_a: CCO:F0001866 ! steroid hydroxylase activity [Term] id: CCO:F0005709 name: 3'-tRNA processing endoribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [EC:3.1.26.11] subset: gosubset_prok synonym: "3 tRNase activity" EXACT [EC:3.1.26.11] synonym: "3' tRNA processing endoribonuclease activity" EXACT [] synonym: "3' tRNase activity" BROAD [] synonym: "ribonuclease Z activity" BROAD [] synonym: "RNase Z activity" BROAD [] synonym: "tRNA 3 endonuclease activity" EXACT [EC:3.1.26.11] synonym: "tRNA 3' endonuclease activity" EXACT [] synonym: "tRNase Z" RELATED [EC:3.1.26.11] synonym: "tRNAse Z" RELATED [EC:3.1.26.11] xref: GO:0042781 is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005710 name: histone lysine N-methyltransferase activity (H4-K20 specific) namespace: molecular_function def: "Catalysis of the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618] comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies. synonym: "histone H4 lysine 20-specific methyltransferase activity" EXACT [] xref: GO:0042799 is_a: CCO:F0003617 ! histone-lysine N-methyltransferase activity [Term] id: CCO:F0005711 name: histone lysine N-methyltransferase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12589755] comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies. synonym: "histone H3 lysine 4-specific methyltransferase activity" EXACT [] xref: GO:0042800 is_a: CCO:F0003617 ! histone-lysine N-methyltransferase activity [Term] id: CCO:F0005712 name: polo kinase kinase activity namespace: molecular_function def: "Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins." [GOC:ma] xref: GO:0042801 is_a: CCO:F0001068 ! receptor signaling protein serine/threonine kinase activity [Term] id: CCO:F0005713 name: identical protein binding namespace: molecular_function def: "Interacting selectively with an identical protein or proteins." [GOC:jl] subset: gosubset_prok synonym: "protein homopolymerization" RELATED [] xref: GO:0042802 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005714 name: protein homodimerization activity namespace: molecular_function def: "Interacting selectively with an identical protein to form a homodimer." [GOC:jl] subset: gosubset_prok synonym: "dimerization activity" BROAD [] xref: GO:0042803 is_a: CCO:F0005713 ! identical protein binding is_a: CCO:F0006300 ! protein dimerization activity [Term] id: CCO:F0005715 name: actinin binding namespace: molecular_function def: "Interacting selectively with actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0042805 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0005716 name: fucose binding namespace: molecular_function def: "Interacting selectively with fucose, a 5-carbon (pentose) sugar." [ISBN:0582227089] xref: GO:0042806 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0005717 name: neuronal Cdc2-like kinase binding namespace: molecular_function def: "Interacting selectively with neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics." [GOC:jl, PMID:10721722] xref: GO:0042808 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0005718 name: vitamin D receptor binding namespace: molecular_function def: "Interacting selectively with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes." [GOC:jl, UniProtKB:P11473] synonym: "calciferol receptor binding" EXACT [] synonym: "VDR binding" EXACT [] xref: GO:0042809 is_a: CCO:F0001738 ! transcription factor binding is_a: CCO:F0005585 ! nuclear hormone receptor binding [Term] id: CCO:F0005719 name: Wnt receptor activity namespace: molecular_function def: "Combining with a member of the Wnt family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] synonym: "frizzled receptor activity" RELATED [] synonym: "frizzled-2 receptor activity" RELATED [] xref: GO:0042813 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0005720 name: histone deacetylase binding namespace: molecular_function def: "Interacting selectively with the enzyme histone deacetylase." [GOC:jl] xref: GO:0042826 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0005721 name: peptidoglycan binding namespace: molecular_function def: "Interacting selectively, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] subset: gosubset_prok xref: GO:0042834 is_a: CCO:F0000239 ! pattern binding [Term] id: CCO:F0005722 name: BRE binding namespace: molecular_function def: "Interacting selectively with the RNA element BRE (Bruno response element)." [PMID:10893231] xref: GO:0042835 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0005723 name: aldarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of aldarate from one side of the membrane to the other." [GOC:go_curators, PMID:15034926] subset: gosubset_prok xref: GO:0042876 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0005724 name: D-galactarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-galactarate, the dextrorotatory isomer of the anion of galactaric acid, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok xref: GO:0042877 is_a: CCO:F0005723 ! aldarate transmembrane transporter activity [Term] id: CCO:F0005725 name: D-glucarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-glucarate, the dextrorotatory isomer of glucarate, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok xref: GO:0042878 is_a: CCO:F0005723 ! aldarate transmembrane transporter activity [Term] id: CCO:F0005726 name: aldonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of aldonate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0042879 is_a: CCO:F0002626 ! hexose transmembrane transporter activity [Term] id: CCO:F0005727 name: D-glucuronate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-glucuronate, the dextrorotatory isomer of glucuronate, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok xref: GO:0042880 is_a: CCO:F0005726 ! aldonate transmembrane transporter activity [Term] id: CCO:F0005728 name: D-galactonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-galactonate, the dextrorotatory isomer of galactonate, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] xref: GO:0042881 is_a: CCO:F0005726 ! aldonate transmembrane transporter activity [Term] id: CCO:F0005729 name: amide transporter activity namespace: molecular_function def: "Enables the directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amine/amide/polyamine channel activity" NARROW [] xref: GO:0042887 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0005730 name: molybdenum ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of molybdenum (Mo) ions from one side of a membrane to the other." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0042888 is_a: CCO:F0006258 ! metal ion transmembrane transporter activity [Term] id: CCO:F0005731 name: 3-phenylpropionic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of 3-phenylpropionic acid from one side of the membrane to the other." [GOC:jl] synonym: "3-phenylpropionate acid transporter activity" EXACT [] synonym: "HCA transporter activity" EXACT [] synonym: "hydrocinnamic acid transporter activity" EXACT [] xref: GO:0042890 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0005732 name: antibiotic transporter activity namespace: molecular_function def: "Enables the directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of, within or between cells." [GOC:jl] subset: gosubset_prok xref: GO:0042895 is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0005733 name: chloramphenicol transporter activity namespace: molecular_function def: "Enables the directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok xref: GO:0042896 is_a: CCO:F0005732 ! antibiotic transporter activity [Term] id: CCO:F0005734 name: polymyxin transporter activity namespace: molecular_function def: "Enables the directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0042897 is_a: CCO:F0005732 ! antibiotic transporter activity [Term] id: CCO:F0005735 name: fosmidomycin transporter activity namespace: molecular_function def: "Enables the directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of, within or between cells." [GOC:jl, PMID:12543685] subset: gosubset_prok xref: GO:0042898 is_a: CCO:F0005732 ! antibiotic transporter activity [Term] id: CCO:F0005736 name: arabinose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729] subset: gosubset_prok xref: GO:0042900 is_a: CCO:F0002623 ! pentose transmembrane transporter activity [Term] id: CCO:F0005737 name: arabinose polymer transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an arabinose polymer, a repeating chain of arabinose monomers, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] xref: GO:0042901 is_a: CCO:F0005736 ! arabinose transmembrane transporter activity [Term] id: CCO:F0005738 name: tubulin deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate." [PMID:12024216, PMID:12486003] xref: GO:0042903 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0005179 ! protein deacetylase activity [Term] id: CCO:F0005739 name: xanthine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl] xref: GO:0042907 is_a: CCO:F0001573 ! purine transmembrane transporter activity [Term] id: CCO:F0005740 name: xenobiotic transporter activity namespace: molecular_function def: "Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of, within or between cells." [GOC:go_curators] subset: gosubset_prok xref: GO:0042910 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0005741 name: acridine transporter activity namespace: molecular_function def: "Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok xref: GO:0042911 is_a: CCO:F0005740 ! xenobiotic transporter activity [Term] id: CCO:F0005742 name: colicin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729] subset: gosubset_prok xref: GO:0042912 is_a: CCO:F0004306 ! bacteriocin transmembrane transporter activity [Term] id: CCO:F0005743 name: group A colicin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417] subset: gosubset_prok xref: GO:0042913 is_a: CCO:F0005742 ! colicin transmembrane transporter activity [Term] id: CCO:F0005744 name: alkylphosphonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an alkylphosphonate from one side of a membrane to the other." [GOC:go_curators] subset: gosubset_prok xref: GO:0042917 is_a: CCO:F0002967 ! phosphonate transmembrane transporter activity [Term] id: CCO:F0005745 name: neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively with one or more specific sites on a neuromedin U receptor." [GOC:jl, PMID:10899166] xref: GO:0042922 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0005746 name: neuropeptide binding namespace: molecular_function def: "Interacting selectively and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [http://cancerweb.ncl.ac.uk/] xref: GO:0042923 is_a: CCO:F0005633 ! neurotransmitter binding is_a: CCO:F0005639 ! peptide binding [Term] id: CCO:F0005747 name: neuromedin U binding namespace: molecular_function def: "Interacting selectively and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses." [GOC:jl, PMID:12584108] synonym: "NMU binding" EXACT [] xref: GO:0042924 is_a: CCO:F0005746 ! neuropeptide binding [Term] id: CCO:F0005748 name: benzoate transporter activity namespace: molecular_function def: "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of, within or between cells." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok xref: GO:0042925 is_a: CCO:F0005740 ! xenobiotic transporter activity [Term] id: CCO:F0005749 name: 3-hydroxyphenylpropionic acid transporter activity namespace: molecular_function def: "Enables the directed movement of 3-hydroxyphenylpropionic acid into, out of, within or between cells." [GOC:jl] subset: gosubset_prok synonym: "3-(3-hydroxyphenyl)propionic acid transporter activity" EXACT [] synonym: "m-hydroxyphenylpropionic acid transporter activity" EXACT [] xref: GO:0042926 is_a: CCO:F0005740 ! xenobiotic transporter activity [Term] id: CCO:F0005750 name: siderophore transporter activity namespace: molecular_function def: "Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of, within or between cells." [GOC:go_curators] subset: gosubset_prok synonym: "siderochrome transporter activity" NARROW [] xref: GO:0042927 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0005751 name: ferrichrome transporter activity namespace: molecular_function def: "Enables the directed movement of a ferrichrome into, out of, within or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0042929 is_a: CCO:F0005750 ! siderophore transporter activity [Term] id: CCO:F0005752 name: enterobactin transporter activity namespace: molecular_function def: "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "enterochelin transporter activity" EXACT [] xref: GO:0042931 is_a: CCO:F0005750 ! siderophore transporter activity [Term] id: CCO:F0005753 name: chrysobactin transporter activity namespace: molecular_function def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of, within or between cells." [GOC:jl, PMID:8837459] subset: gosubset_prok xref: GO:0042933 is_a: CCO:F0005750 ! siderophore transporter activity [Term] id: CCO:F0005754 name: achromobactin transporter activity namespace: molecular_function def: "Enables the directed movement of achromobactin, a citrate siderophore, into, out of, within or between cells." [GOC:jl] subset: gosubset_prok xref: GO:0042934 is_a: CCO:F0005750 ! siderophore transporter activity is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0005755 name: dipeptide transporter activity namespace: molecular_function def: "Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok xref: GO:0042936 is_a: CCO:F0002672 ! oligopeptide transporter activity [Term] id: CCO:F0005756 name: tripeptide transporter activity namespace: molecular_function def: "Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok xref: GO:0042937 is_a: CCO:F0002672 ! oligopeptide transporter activity [Term] id: CCO:F0005757 name: D-amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the dextrorotatory isomer of amino acids." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-amino acid transporter activity" BROAD [] xref: GO:0042943 is_a: CCO:F0002648 ! amino acid transmembrane transporter activity [Term] id: CCO:F0005758 name: D-alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-alanine from one side of a membrane to the other. D-alanine is the dextrorotatory isomer of 2-aminopropanoic acid." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-alanine transporter activity" BROAD [] xref: GO:0042944 is_a: CCO:F0004285 ! alanine transmembrane transporter activity is_a: CCO:F0005757 ! D-amino acid transmembrane transporter activity [Term] id: CCO:F0005759 name: D-serine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-serine from one side of a membrane to the other. D-serine is the dextrorotatory isomer of 2-amino-3-hydroxypropanoic acid." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-serine permease activity" EXACT [] synonym: "D-serine transporter activity" BROAD [] xref: GO:0042945 is_a: CCO:F0004308 ! serine transmembrane transporter activity is_a: CCO:F0005757 ! D-amino acid transmembrane transporter activity [Term] id: CCO:F0005760 name: glucoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar moiety is a glucose residue." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: GO:0042947 is_a: CCO:F0008062 ! sugar transmembrane transporter activity [Term] id: CCO:F0005761 name: salicin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729] subset: gosubset_prok xref: GO:0042950 is_a: CCO:F0002953 ! beta-glucoside transmembrane transporter activity [Term] id: CCO:F0005762 name: arbutin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://biotech.icmb.utexas.edu/, ISBN:0815340729] xref: GO:0042951 is_a: CCO:F0002953 ! beta-glucoside transmembrane transporter activity [Term] id: CCO:F0005763 name: lipoprotein transporter activity namespace: molecular_function def: "Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0042954 is_a: CCO:F0001997 ! protein transporter activity [Term] id: CCO:F0005764 name: dextrin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of the membrane to the other." [GOC:jl, GOC:vk, http://www.mercksource.com/] subset: gosubset_prok xref: GO:0042957 is_a: CCO:F0002636 ! polysaccharide transmembrane transporter activity [Term] id: CCO:F0005765 name: maltodextrin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of the membrane to the other." [GOC:jl, http://www.mercksource.com/, PMID:15034926] subset: gosubset_prok xref: GO:0042958 is_a: CCO:F0005764 ! dextrin transmembrane transporter activity [Term] id: CCO:F0005766 name: alkanesulfonate transporter activity namespace: molecular_function def: "Enables the directed movement of alkanesulfonate into, out of, within or between cells." [GOC:jl] subset: gosubset_prok synonym: "alkanesulphonate transporter activity" EXACT [] xref: GO:0042959 is_a: CCO:F0005740 ! xenobiotic transporter activity [Term] id: CCO:F0005767 name: antimonite secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl] subset: gosubset_prok synonym: "antimonite porter activity" RELATED [] xref: GO:0042960 is_a: CCO:F0002582 ! antimonite transmembrane transporter activity is_a: CCO:F0002740 ! secondary active transmembrane transporter activity [Term] id: CCO:F0005768 name: antimonite-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:3.6.3.16] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "antimonite ABC transporter" NARROW [] xref: GO:0042961 is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances is_a: CCO:F0005767 ! antimonite secondary active transmembrane transporter activity [Term] id: CCO:F0005769 name: acridine:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)." [PMID:10735876] subset: gosubset_prok synonym: "acridine efflux pump activity" RELATED [] synonym: "acridine:proton antiporter activity" EXACT [] xref: GO:0042962 is_a: CCO:F0002748 ! solute:hydrogen antiporter activity is_a: CCO:F0005741 ! acridine transporter activity [Term] id: CCO:F0005770 name: homoserine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "homoserine transporter activity" BROAD [] xref: GO:0042970 is_a: CCO:F0002652 ! neutral amino acid transmembrane transporter activity [Term] id: CCO:F0005771 name: lactone transporter activity namespace: molecular_function def: "Enables the directed movement of lactone, any of a series of organic compounds, regarded as anhydrides of certain hydroxy acids, into, out of, within or between cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok xref: GO:0042971 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0005772 name: licheninase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in beta-D-glucans containing 1,3- and 1,4-bonds." [EC:3.2.1.73] subset: gosubset_prok synonym: "1,3-1,4-beta-D-glucan 4-glucanohydrolase activity" EXACT [] synonym: "1,3-1,4-beta-glucan 4-glucanohydrolase activity" EXACT [] synonym: "1,3;1,4-beta-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73] synonym: "1,3;1,4-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.73] synonym: "beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73] synonym: "beta-glucanase activity" BROAD [EC:3.2.1.73] synonym: "endo-beta-1,3-1,4 glucanase activity" EXACT [EC:3.2.1.73] synonym: "lichenase activity" EXACT [] synonym: "mixed linkage beta-glucanase activity" RELATED [EC:3.2.1.73] xref: EC:3.2.1.73 xref: GO:0042972 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005773 name: glucan endo-1,3-beta-D-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans." [EC:3.2.1.39] subset: gosubset_prok synonym: "(1->3)-beta-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39] synonym: "(1->3)-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.39] synonym: "1,3-beta-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39] synonym: "1,3-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.39] synonym: "beta-1,3-glucanase" BROAD [EC:3.2.1.39] synonym: "callase activity" EXACT [EC:3.2.1.39] synonym: "endo-(1,3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] synonym: "endo-(1->3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] synonym: "endo-1,3-beta-D-glucanase" BROAD [EC:3.2.1.39] synonym: "endo-1,3-beta-glucanase activity" BROAD [] synonym: "endo-1,3-beta-glucosidase activity" BROAD [EC:3.2.1.39] synonym: "kitalase activity" EXACT [EC:3.2.1.39] synonym: "laminaranase activity" BROAD [] synonym: "laminarinase activity" BROAD [] synonym: "oligo-1,3-glucosidase activity" RELATED [EC:3.2.1.39] xref: EC:3.2.1.39 xref: GO:0042973 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0005774 name: retinoic acid receptor binding namespace: molecular_function def: "Interacting selectively with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily." [GOC:jl, PMID:12476796] synonym: "RAR binding" EXACT [] xref: GO:0042974 is_a: CCO:F0001738 ! transcription factor binding is_a: CCO:F0005585 ! nuclear hormone receptor binding [Term] id: CCO:F0005775 name: peroxisome proliferator activated receptor binding namespace: molecular_function def: "Interacting selectively with any of the peroxisome proliferator activated receptors, alpha, beta or gamma." [GOC:jl, PMID:12769781] synonym: "PPAR binding" EXACT [] xref: GO:0042975 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0005776 name: ornithine decarboxylase activator activity namespace: molecular_function def: "Upregulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl] synonym: "L-ornithine carboxy-lyase activator activity" NARROW [] xref: GO:0042978 is_a: CCO:F0001691 ! enzyme activator activity is_a: CCO:F0005777 ! ornithine decarboxylase regulator activity [Term] id: CCO:F0005777 name: ornithine decarboxylase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl] xref: GO:0042979 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0005778 name: cystic fibrosis transmembrane conductance regulator binding namespace: molecular_function def: "Interacting selectively with the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein." [GOC:jl] synonym: "CFTR binding" EXACT [] xref: GO:0042980 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005779 name: X11-like protein binding namespace: molecular_function def: "Interacting selectively with X11-like protein, a neuron-specific adaptor protein." [GOC:jl, PMID:12780348] synonym: "X11L binding" EXACT [] xref: GO:0042988 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005780 name: ATP-dependent protein binding namespace: molecular_function def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP." [GOC:jl] xref: GO:0043008 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005781 name: alpha-tubulin binding namespace: molecular_function def: "Interacting selectively with the microtubule constituent protein alpha-tubulin." [GOC:jl] synonym: "alpha tubulin binding" EXACT [] xref: GO:0043014 is_a: CCO:F0002987 ! tubulin binding [Term] id: CCO:F0005782 name: gamma-tubulin binding namespace: molecular_function def: "Interacting selectively with the microtubule constituent protein gamma-tubulin." [GOC:jl] synonym: "gamma tubulin binding" EXACT [] xref: GO:0043015 is_a: CCO:F0002987 ! tubulin binding [Term] id: CCO:F0005783 name: ribonucleoprotein binding namespace: molecular_function def: "Interacting selectively with any complex of RNA and protein." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "RNP binding" EXACT [] xref: GO:0043021 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005784 name: ribosome binding namespace: molecular_function def: "Interacting selectively with any part of a ribosome." [GOC:go_curators] subset: gosubset_prok synonym: "ribosome receptor activity" NARROW [] xref: GO:0030376 xref: GO:0043022 is_a: CCO:F0005783 ! ribonucleoprotein binding [Term] id: CCO:F0005785 name: ribosomal large subunit binding namespace: molecular_function def: "Interacting selectively with any part of the larger ribosomal subunit." [GOC:go_curators] subset: gosubset_prok xref: GO:0043023 is_a: CCO:F0005783 ! ribonucleoprotein binding [Term] id: CCO:F0005786 name: ribosomal small subunit binding namespace: molecular_function def: "Interacting selectively with any part of the small ribosomal subunit." [GOC:go_curators] subset: gosubset_prok xref: GO:0043024 is_a: CCO:F0005783 ! ribonucleoprotein binding [Term] id: CCO:F0005787 name: caspase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl, http://en.wikipedia.org/wiki/ "Wikipedia"] xref: GO:0043027 is_a: CCO:F0001222 ! endopeptidase inhibitor activity is_a: CCO:F0005788 ! caspase regulator activity [Term] id: CCO:F0005788 name: caspase regulator activity namespace: molecular_function def: "Modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl, http://en.wikipedia.org/wiki/ "Wikipedia"] xref: GO:0043028 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0005789 name: chromatin insulator sequence binding namespace: molecular_function def: "Interacting selectively and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795] xref: GO:0043035 is_a: CCO:F0004674 ! chromatin DNA binding [Term] id: CCO:F0005790 name: single-stranded telomeric DNA binding namespace: molecular_function def: "Interacting selectively with single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] xref: GO:0043047 is_a: CCO:F0000288 ! single-stranded DNA binding is_a: CCO:F0005630 ! telomeric DNA binding [Term] id: CCO:F0005791 name: GTP cyclohydrolase I binding namespace: molecular_function def: "Interacting selectively with the enzyme GTP cyclohydrolase I." [GOC:jl] xref: GO:0043106 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0005792 name: rDNA spacer replication fork barrier binding namespace: molecular_function def: "Interacting selectively with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [GOC:jl, GOC:mah, PMID:14645529] synonym: "RFB binding" EXACT [] xref: GO:0043110 is_a: CCO:F0000036 ! rDNA binding is_a: CCO:F0004692 ! replication fork barrier binding [Term] id: CCO:F0005793 name: precorrin-2 dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-2 (dihydrosirohydrochlorin) + NAD+ = sirohydrochlorin + NADH + H+." [EC:1.3.1.76] subset: gosubset_prok synonym: "1,3-dimethyluroporphyrinogen III dehydrogenase activity" EXACT [] synonym: "CysG" RELATED [EC:1.3.1.76] synonym: "dihydrosirohydrochlorin dehydrogenase activity" EXACT [] synonym: "Met8p" RELATED [EC:1.3.1.76] synonym: "precorrin-2 oxidase activity" EXACT [EC:1.3.1.76] synonym: "precorrin-2:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.76] synonym: "SirC" RELATED [EC:1.3.1.76] synonym: "siroheme synthase activity" BROAD [] xref: EC:1.3.1.76 xref: GO:0043115 xref: MetaCyc:DIMETHUROPORDEHYDROG-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005794 name: tumor necrosis factor binding namespace: molecular_function def: "Interacting selectively with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages." [GOC:jl, http://lookwayup.com/] xref: GO:0043120 is_a: CCO:F0004221 ! cytokine binding [Term] id: CCO:F0005795 name: neurotrophin binding namespace: molecular_function def: "Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth." [GOC:jl, http://www.mercksource.com/] synonym: "neurotrophin TRK receptor activity" RELATED [] xref: GO:0043121 is_a: CCO:F0004188 ! growth factor binding [Term] id: CCO:F0005796 name: ErbB-3 class receptor binding namespace: molecular_function def: "Interacting selectively with the protein-tyrosine kinase receptor ErbB-3/HER3." [GOC:jl] synonym: "HER3 receptor binding" EXACT [] synonym: "Neu/ErbB-2 receptor activity" RELATED [] xref: GO:0043125 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0005797 name: ubiquitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] xref: GO:0043130 is_a: CCO:F0004963 ! small conjugating protein binding [Term] id: CCO:F0005798 name: 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the diphosphate bond in 5-phosphoribosyl 1-pyrophosphate." [GOC:jl, http://cancerweb.ncl.ac.uk, PMID:12370170] synonym: "PRPP pyrophosphatase activity" EXACT [] xref: GO:0043135 is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0005799 name: glycerol-3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate." [GOC:jl] xref: GO:0043136 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0005800 name: 3'-5' DNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] synonym: "3' to 5' DNA helicase activity" EXACT [] xref: GO:0043138 is_a: CCO:F0000275 ! DNA helicase activity [Term] id: CCO:F0005801 name: 5'-3' DNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] synonym: "5' to 3' DNA helicase activity" EXACT [] xref: GO:0043139 is_a: CCO:F0000275 ! DNA helicase activity [Term] id: CCO:F0005802 name: ATP-dependent 3'-5' DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT [] xref: GO:0043140 is_a: CCO:F0000487 ! ATP-dependent DNA helicase activity is_a: CCO:F0005800 ! 3'-5' DNA helicase activity [Term] id: CCO:F0005803 name: ATP-dependent 5'-3' DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT [] synonym: "DNA helicase IV activity" NARROW [] xref: EC:3.6.1.- xref: GO:0008722 xref: GO:0043141 is_a: CCO:F0000487 ! ATP-dependent DNA helicase activity is_a: CCO:F0005801 ! 5'-3' DNA helicase activity [Term] id: CCO:F0005804 name: single-stranded DNA-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single-stranded DNA; drives another reaction." [GOC:go_curators] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ssDNA-dependent ATPase activity" EXACT [] xref: GO:0043142 is_a: CCO:F0001707 ! DNA-dependent ATPase activity [Term] id: CCO:F0005805 name: H4/H2A histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H4 and (to a lesser extent) H2A." [GOC:jl, PMID:10911987, PMID:9241414] synonym: "H4/H2A acetyltransferase activity" EXACT [] xref: GO:0043166 is_a: CCO:F0000813 ! histone acetyltransferase activity [Term] id: CCO:F0005806 name: ion binding namespace: molecular_function def: "Interacting selectively with ions, charged atoms or groups of atoms." [GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "atom binding" RELATED [] xref: GO:0043167 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005807 name: anion binding namespace: molecular_function def: "Interacting selectively with anions, charged atoms or groups of atoms with a net negative charge." [GOC:jl] subset: gosubset_prok xref: GO:0043168 is_a: CCO:F0005806 ! ion binding [Term] id: CCO:F0005808 name: cation binding namespace: molecular_function def: "Interacting selectively with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl] subset: gosubset_prok xref: GO:0043169 is_a: CCO:F0005806 ! ion binding [Term] id: CCO:F0005809 name: RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively with the prokaryotic RNA polymerase core enzyme, the part of the RNA polymerase consisting of two alpha, one beta and one beta prime subunits." [GOC:jl, ISBN:0321000382] subset: gosubset_prok xref: GO:0043175 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0005810 name: amine binding namespace: molecular_function def: "Interacting selectively with any organic compound that is weakly basic in character and contains an amino or a substituted amino group." [GOC:jl] subset: goslim_pir subset: gosubset_prok xref: GO:0043176 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005811 name: organic acid binding namespace: molecular_function def: "Interacting selectively with an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0043177 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005812 name: alcohol binding namespace: molecular_function def: "Interacting selectively with an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok xref: GO:0043178 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005813 name: vascular endothelial growth factor receptor 1 binding namespace: molecular_function def: "Interacting selectively with vascular endothelial growth factor receptor 1." [GOC:st] synonym: "Flt-1 binding" EXACT [] synonym: "VEGF receptor 1 binding" EXACT [] synonym: "VEGFR 1 binding" EXACT [] xref: GO:0043183 is_a: CCO:F0001473 ! vascular endothelial growth factor receptor binding [Term] id: CCO:F0005814 name: vascular endothelial growth factor receptor 2 binding namespace: molecular_function def: "Interacting selectively with vascular endothelial growth factor receptor 2." [GOC:st] synonym: "Flk-1 binding" EXACT [] synonym: "KDR binding" BROAD [] synonym: "kinase domain region binding" EXACT [] synonym: "VEGF receptor 2 binding" EXACT [] synonym: "VEGFR 2 binding" EXACT [] xref: GO:0043184 is_a: CCO:F0001473 ! vascular endothelial growth factor receptor binding [Term] id: CCO:F0005815 name: vascular endothelial growth factor receptor 3 binding namespace: molecular_function def: "Interacting selectively with vascular endothelial growth factor receptor 3." [GOC:st] synonym: "fms-like-tyrosine kinase (Flt)-4 binding" EXACT [] synonym: "VEGF receptor 3 binding" EXACT [] synonym: "VEGFR 3 binding" EXACT [] xref: GO:0043185 is_a: CCO:F0001473 ! vascular endothelial growth factor receptor binding [Term] id: CCO:F0005816 name: sulfate binding namespace: molecular_function def: "Interacting selectively with sulfate (SO42-), a negatively charged small molecule." [GOC:mlg] subset: gosubset_prok xref: GO:0043199 is_a: CCO:F0005807 ! anion binding [Term] id: CCO:F0005817 name: glycosphingolipid binding namespace: molecular_function def: "Interacting selectively with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl] xref: GO:0043208 is_a: CCO:F0006239 ! sphingolipid binding is_a: CCO:F0008198 ! glycolipid binding [Term] id: CCO:F0005818 name: alkanesulfonate binding namespace: molecular_function def: "Interacting selectively with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety." [GOC:mlg] subset: gosubset_prok xref: GO:0043210 is_a: CCO:F0005807 ! anion binding [Term] id: CCO:F0005819 name: carbohydrate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of carbohydrates across a membrane." [GOC:mlg] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "carbohydrate ABC transporter" NARROW [] xref: GO:0043211 is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0005820 name: carbohydrate-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) = ADP + phosphate + carbohydrate(out)." [GOC:mlg] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok xref: GO:0043212 is_a: CCO:F0005819 ! carbohydrate-transporting ATPase activity [Term] id: CCO:F0005821 name: bacteriocin-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of bacteriocins across a membrane." [GOC:mlg] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "bacteriocin ABC transporter" NARROW [] xref: GO:0043214 is_a: CCO:F0002869 ! protein-transmembrane transporting ATPase activity [Term] id: CCO:F0005822 name: daunorubicin-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out)." [GOC:mlg] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "daunorubicin ABC transporter" NARROW [] xref: GO:0043216 is_a: CCO:F0002706 ! drug transporter activity is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0005823 name: SMC protein binding namespace: molecular_function def: "Interacting selectively with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization." [GOC:jl, PMID:9640531] xref: GO:0043221 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005824 name: anion transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in)." [GOC:mlg] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "anion ABC transporter" NARROW [] synonym: "anion-transporting ATPase activity" EXACT [] xref: GO:0043225 is_a: CCO:F0001962 ! anion transmembrane transporter activity is_a: CCO:F0005698 ! ATPase activity, coupled to transmembrane movement of ions [Term] id: CCO:F0005825 name: laminin binding namespace: molecular_function def: "Interacting selectively with laminins, glycoproteins that are major constituents of the basement membrane of cells." [GOC:ecd] xref: GO:0043236 is_a: CCO:F0001646 ! protein binding is_a: CCO:F0008024 ! extracellular matrix binding [Term] id: CCO:F0005826 name: laminin-1 binding namespace: molecular_function def: "Interacting selectively with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1." [GOC:go_curators] xref: GO:0043237 is_a: CCO:F0005825 ! laminin binding [Term] id: CCO:F0005827 name: laminin-2 binding namespace: molecular_function def: "Interacting selectively with laminin-2, a glycoprotein trimer with the subunit composition alpha2, beta1, gamma 1." [GOC:go_curators] xref: GO:0043238 is_a: CCO:F0005825 ! laminin binding [Term] id: CCO:F0005828 name: laminin-4 binding namespace: molecular_function def: "Interacting selectively with laminin-4, a glycoprotein trimer with the subunit composition alpha2, beta2, gamma 1." [GOC:go_curators] xref: GO:0043239 is_a: CCO:F0005825 ! laminin binding [Term] id: CCO:F0005829 name: sodium-dependent organic anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner." [GOC:go_curators] xref: GO:0043250 is_a: CCO:F0001967 ! organic anion transmembrane transporter activity [Term] id: CCO:F0005830 name: adenosine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + H2O = AMP + phosphate." [EC:3.6.1.5, PMID:1470606] synonym: "adenosine diphosphatase activity" EXACT [] synonym: "adenosinepyrophosphatase activity" EXACT [EC:3.6.1.6] synonym: "ADPase" BROAD [EC:3.6.1.3] synonym: "ADPase activity" EXACT [EC:3.6.1.6] synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.3] synonym: "ATP diphosphohydrolase (phosphate-forming) activity" EXACT [EC:3.6.1.3] synonym: "ATP-diphosphatase activity" EXACT [EC:3.6.1.3] synonym: "ATP-diphosphohydrolase activity" EXACT [EC:3.6.1.3] xref: GO:0043262 is_a: CCO:F0003573 ! nucleoside-diphosphatase activity [Term] id: CCO:F0005831 name: CTPase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators] synonym: "cytidine triphosphatase activity" EXACT [] xref: GO:0043273 is_a: CCO:F0003574 ! nucleoside-triphosphatase activity [Term] id: CCO:F0005832 name: phospholipase binding namespace: molecular_function def: "Interacting selectively with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid." [GOC:jl] xref: GO:0043274 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0005833 name: glutamate carboxypeptidase II activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [BRENDA:3.4.17.21, GOC:jl] comment: Note that this function was formerly EC:3.4.19.8. synonym: "acetylaspartylglutamate dipeptidase activity" EXACT [] synonym: "folate hydrolase activity" RELATED [EC:3.4.17.21] synonym: "folylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "membrane glutamate carboxypeptidase" NARROW [EC:3.4.17.21] synonym: "mGCP" RELATED [EC:3.4.17.21] synonym: "microsomal gamma-glutamyl carboxypeptidase" NARROW [EC:3.4.17.21] synonym: "N-acetylated alpha-linked acidic dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "N-acetylated-alpha-linked-amino dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)" EXACT [EC:3.4.17.21] synonym: "N-acetylated-gamma-linked-acidic dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "NAALA dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "NAALADase activity" EXACT [EC:3.4.17.21] synonym: "prostate-specific membrane antigen" RELATED [EC:3.4.17.21] synonym: "prostrate-specific membrane antigen" RELATED [EC:3.4.17.21] synonym: "PSM antigen" RELATED [EC:3.4.17.21] synonym: "PSMA" RELATED [EC:3.4.17.21] synonym: "pteroylpoly-gamma-glutamate carboxypeptidase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpoly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolygammaglutamyl hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolyglutamic acid hydrolase activity" EXACT [EC:3.4.17.21] synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21] xref: EC:3.4.17.21 xref: GO:0043275 is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0005834 name: poly(3-hydroxyalkanoate) binding namespace: molecular_function def: "Interacting selectively with poly(3-hydroxyalkanoate)s, polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl] subset: gosubset_prok synonym: "PHA binding" EXACT [] xref: GO:0043287 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005835 name: glutathione binding namespace: molecular_function def: "Interacting selectively with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0043295 is_a: CCO:F0005639 ! peptide binding [Term] id: CCO:F0005836 name: phosphatidylinositol-3,4-bisphosphate binding namespace: molecular_function def: "Interacting selectively with phosphatidylinositol-3,4-bisphosphate, a diphosphorylated derivative of phosphatidylinositol." [GOC:go_curators] xref: GO:0043325 is_a: CCO:F0005562 ! phosphoinositide binding [Term] id: CCO:F0005837 name: 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9045837] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: GO:0043333 is_a: CCO:F0001892 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: CCO:F0005838 name: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: GO:0043334 is_a: CCO:F0001892 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: CCO:F0005839 name: site-specific telomere resolvase activity namespace: molecular_function def: "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases." [GOC:jl, PMID:11804598] comment: Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres. synonym: "ResT" NARROW [] synonym: "TelN" NARROW [] xref: GO:0043336 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0005840 name: CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin)." [GOC:jl] synonym: "cardiolipin synthase" BROAD [] synonym: "cardiolipin synthetase" BROAD [] xref: GO:0043337 is_a: CCO:F0004483 ! phosphatidyltransferase activity [Term] id: CCO:F0005841 name: CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase namespace: molecular_function def: "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol." [GOC:jl, PMID:10960477] synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase" BROAD [] xref: EC:2.7.7.- xref: GO:0043338 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0005842 name: catalysis of free radical formation namespace: molecular_function def: "Catalysis of a reaction that generates a free radical, a highly reactive molecule with an unsatisfied electron valence pair." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: goslim_pir synonym: "catalysis of free radical generation" EXACT [] synonym: "catalysis of free-radical biosynthesis" EXACT [] synonym: "catalysis of free-radical formation" EXACT [] synonym: "catalysis of free-radical generation" EXACT [] xref: GO:0043364 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0005844 name: proteoglycan binding namespace: molecular_function def: "Interacting selectively with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0043394 is_a: CCO:F0000251 ! glycoprotein binding [Term] id: CCO:F0005845 name: heparan sulfate proteoglycan binding namespace: molecular_function def: "Interacting selectively with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0043395 is_a: CCO:F0005844 ! proteoglycan binding [Term] id: CCO:F0005846 name: HLH domain binding namespace: molecular_function def: "Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization." [GOC:go_curators, Prosite:PDOC0038] xref: GO:0043398 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0005847 name: tRNA A64-2'-O-ribosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, UniProtKB:P23796] synonym: "initiator tRNA phosphoribosyl-transferase activity" EXACT [] xref: GO:0043399 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0005848 name: corticotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with corticotropin-releasing hormone to initiate a change in cell activity." [ISBN:0838577016, PMID:11027914, PMID:15134857] xref: GO:0043404 is_a: CCO:F0001226 ! receptor activity is_a: CCO:F0008107 ! corticotropin-releasing hormone binding [Term] id: CCO:F0005849 name: myopalladin binding namespace: molecular_function def: "Interacting selectively with myopalladin, a myofibrillar protein with titin-like Ig domains." [GOC:go_curators] xref: GO:0043411 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0005850 name: protein kinase B binding namespace: molecular_function def: "Interacting selectively with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism." [GOC:jl, http://www.heartandmetabolism.org/] synonym: "Akt binding" EXACT [] synonym: "PKB binding" EXACT [] xref: GO:0043422 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0005851 name: 3-phosphoinositide-dependent protein kinase binding namespace: molecular_function def: "Interacting selectively with a 3-phosphoinositide-dependent protein kinase." [GOC:jl] xref: GO:0043423 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0005852 name: protein histidine kinase binding namespace: molecular_function def: "Interacting selectively with protein histidine kinase." [GOC:jl] synonym: "histidine kinase binding" EXACT [] synonym: "histidine-protein kinase binding" EXACT [] synonym: "protein-histidine kinase binding" EXACT [] xref: GO:0043424 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0005853 name: bHLH transcription factor binding namespace: molecular_function def: "Interacting selectively with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transciptional networks of many developmental pathways." [PMID:9144210] xref: GO:0043425 is_a: CCO:F0001738 ! transcription factor binding [Term] id: CCO:F0005854 name: MRF binding namespace: molecular_function def: "Interacting selectively with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of trascription factors." [PMID:10966875] xref: GO:0043426 is_a: CCO:F0005853 ! bHLH transcription factor binding [Term] id: CCO:F0005855 name: 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: GO:0043428 is_a: CCO:F0001892 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: CCO:F0005856 name: 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: GO:0043429 is_a: CCO:F0001892 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: CCO:F0005857 name: 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: GO:0043430 is_a: CCO:F0001892 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: CCO:F0005858 name: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838, PMID:1479344] synonym: "2-octaprenyl-6-hydroxy phenol methylase activity" EXACT [] synonym: "3-demethylubiquinone-9 3-methyltransferase activity" EXACT [] xref: GO:0043431 is_a: CCO:F0001758 ! O-methyltransferase activity [Term] id: CCO:F0005859 name: IgD binding namespace: molecular_function def: "Interacting selectively with an immunoglobulin of a D isotype." [PMID:12886015] xref: GO:0043472 is_a: CCO:F0004198 ! immunoglobulin binding [Term] id: CCO:F0005860 name: ATPase activity, coupled to movement of substances namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance." [GOC:jl] subset: gosubset_prok xref: GO:0043492 is_a: CCO:F0005696 ! ATPase activity, coupled [Term] id: CCO:F0005861 name: protein anchor namespace: molecular_function def: "Interacting selectively with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane." [GOC:go_curators] synonym: "anchoring" RELATED [] xref: GO:0043495 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005862 name: cell surface binding namespace: molecular_function def: "Interacting selectively with any component on the surface of a cell." [GOC:jl] subset: goslim_pir subset: gosubset_prok xref: GO:0043498 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005863 name: eukaryotic cell surface binding namespace: molecular_function def: "Interacting selectively with any component on the surface of a eukaryotic cell." [GOC:jl] xref: GO:0043499 is_a: CCO:F0005862 ! cell surface binding [Term] id: CCO:F0005864 name: kinetochore binding namespace: molecular_function def: "Interacting selectively with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl, http://www.mercksource.com/] xref: GO:0043515 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0005865 name: leucine zipper domain binding namespace: molecular_function def: "Interacting selectively with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns." [GOC:jl, InterPro:IPR002158] synonym: "leucine zipper binding" EXACT [] xref: GO:0043522 is_a: CCO:F0004371 ! LRR domain binding [Term] id: CCO:F0005866 name: adenosine 5'-monophosphoramidase activity namespace: molecular_function def: "Catalysis of the reaction: AMP-NH2 (adenosine 5'-monophosphoramidate) = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." [PMID:11805111] synonym: "adenosine 5' monophosphoramidase activity" EXACT [] synonym: "adenosine 5'-monophosphoramidate hydrolase activity" EXACT [] xref: GO:0043530 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005867 name: ADP binding namespace: molecular_function def: "Interacting selectively with ADP, adenosine 5'-diphosphate." [GOC:jl] synonym: "adenosine 5'-diphosphate binding" EXACT [] synonym: "adenosine diphosphate binding" EXACT [] xref: GO:0043531 is_a: CCO:F0005022 ! adenyl ribonucleotide binding [Term] id: CCO:F0005868 name: angiostatin binding namespace: molecular_function def: "Interacting selectively with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488] xref: GO:0043532 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005869 name: inositol 1,3,4,5 tetrakisphosphate binding namespace: molecular_function def: "Interacting selectively with inositol 1,3,4,5 tetrakisphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "InsP4 binding" EXACT [] synonym: "IP4 binding" EXACT [] xref: GO:0043533 is_a: CCO:F0005812 ! alcohol binding [Term] id: CCO:F0005870 name: protein serine/threonine kinase activator activity namespace: molecular_function def: "Increases the activity of a protein serine/threonine kinase." [GOC:go_curators] synonym: "protein ser/thr kinase activator activity" EXACT [] xref: GO:0043539 is_a: CCO:F0004382 ! protein kinase activator activity [Term] id: CCO:F0005871 name: lipoamide binding namespace: molecular_function def: "Interacting selectively with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators] xref: GO:0043544 is_a: CCO:F0004659 ! lipoic acid binding [Term] id: CCO:F0005872 name: molybdopterin cofactor binding namespace: molecular_function def: "Interacting selectively with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] synonym: "Moco binding" EXACT [] xref: GO:0043546 is_a: CCO:F0007988 ! coenzyme binding [Term] id: CCO:F0005873 name: phosphoinositide 3-kinase binding namespace: molecular_function def: "Interacting selectively with a phosphoinositide 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069] xref: GO:0043548 is_a: CCO:F0004209 ! kinase binding [Term] id: CCO:F0005874 name: insulin binding namespace: molecular_function def: "Interacting selectively with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0043559 is_a: CCO:F0003529 ! peptide hormone binding [Term] id: CCO:F0005875 name: insulin receptor substrate binding namespace: molecular_function def: "Interacting selectively with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex." [PMID:12829233] synonym: "insulin receptor substrate [protein] binding" EXACT [] synonym: "IRS [protein] binding" EXACT [] synonym: "IRS binding" EXACT [] xref: GO:0043560 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005876 name: odorant transporter activity namespace: molecular_function def: "Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of, within or between cells." [GOC:jl] subset: gosubset_prok xref: GO:0043563 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0005877 name: sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] subset: gosubset_prok synonym: "sequence specific DNA binding" EXACT [] xref: GO:0043565 is_a: CCO:F0000274 ! DNA binding [Term] id: CCO:F0005878 name: structure-specific DNA binding namespace: molecular_function def: "Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding." [GOC:jl] subset: gosubset_prok synonym: "structure specific DNA binding" EXACT [] xref: GO:0043566 is_a: CCO:F0000274 ! DNA binding [Term] id: CCO:F0005879 name: protein self-association namespace: molecular_function def: "Interacting selectively with a domain within the same polypeptide." [GOC:jl] synonym: "intramolecular protein binding" EXACT [] synonym: "protein self association" EXACT [] synonym: "protein self binding" EXACT [] xref: GO:0043621 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0005880 name: copper-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane." [GOC:jl] subset: gosubset_prok xref: GO:0043682 is_a: CCO:F0001598 ! copper ion transmembrane transporter activity is_a: CCO:F0003011 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: CCO:F0005881 name: 2-hydroxyisocaproate CoA-transferase namespace: molecular_function def: "Catalysis of the reaction: 2-oxoisocaproate + CoA = (R)-2-hydroxyisocaproyl-CoA." [PMID:16957230] synonym: "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT [] synonym: "(R)-2-hydroxyisocaproate CoA-transferase activity" EXACT [] xref: GO:0043712 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0005884 name: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity namespace: molecular_function def: "Catalysis of the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)." [UniProt:Q81MJ2] comment: This function is part of the process of methionine salvage. subset: gosubset_prok synonym: "DK-MTP-1-P enolase activity" EXACT [] synonym: "E-1" RELATED [] synonym: "MasA" RELATED [] synonym: "mtnW" RELATED [] xref: EC:5.3.2.- xref: GO:0043715 xref: MetaCyc:R82-RXN is_a: CCO:F0003424 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: CCO:F0005885 name: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity namespace: molecular_function def: "Cataysis of the dephosphorylation of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-P) to 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)." [IMG:01681, UniProt:O31667] subset: gosubset_prok synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT [] xref: GO:0043716 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0005886 name: 2-hydroxyglutaryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the dehydration of 2-hydroxyglutaryl-CoA to glutaconyl-CoA." [UniProt:P11569] subset: gosubset_prok synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT [] xref: GO:0043717 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005887 name: 2-hydroxymethylglutarate dehydrogenase namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+." [EC:1.1.1.291] subset: gosubset_prok synonym: "(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.291] synonym: "HgD" EXACT [] xref: EC:1.1.1.291 xref: GO:0043718 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005888 name: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase namespace: molecular_function def: "Catalysis of the introduction of a hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol to form 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol." [GOC:jl, UniProt:P75728] subset: gosubset_prok xref: EC:1.14.13.- xref: GO:0043719 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005889 name: 3-keto-5-aminohexanoate cleavage activity namespace: molecular_function def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [PMID:13064] subset: gosubset_prok synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT [] xref: GO:0043720 xref: MetaCyc:R125-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005890 name: 4-hydroxybutyryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the formation of vinylacetyl-CoA from 4-hydroxybutyryl-CoA." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "gamma-hydroxybutyryl-CoA dehydratase activity" EXACT [] xref: EC:4.2.1.- xref: GO:0043721 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005891 name: 4-hydroxyphenylacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-methylphenol + CO2." [EC:4.1.1.83] subset: gosubset_prok synonym: "4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)" EXACT [EC:4.1.1.83] synonym: "4-Hpd activity" EXACT [EC:4.1.1.83] synonym: "4-hydroxyphenylacetate carboxy-lyase activity" EXACT [EC:4.1.1.83] synonym: "p-Hpd activity" EXACT [EC:4.1.1.83] synonym: "p-hydroxyphenylacetate decarboxylase activity" EXACT [EC:4.1.1.83] xref: EC:4.1.1.83 xref: GO:0043722 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0005892 name: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase namespace: molecular_function def: "Catalysis of the reaction: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NH3." [PMID:11889103] subset: gosubset_prok synonym: "2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity" EXACT [] xref: EC:3.5.4.- xref: GO:0043723 is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: CCO:F0005893 name: 2-keto-3-deoxygalactonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate." [PMID:12824170] subset: gosubset_prok synonym: "KDGal aldolase activity" EXACT [] xref: EC:4.2.1.- xref: GO:0043724 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005894 name: 2-keto-3-deoxygluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate." [PMID:12824170] subset: gosubset_prok synonym: "KDG aldolase activity" EXACT [] xref: EC:4.2.1.- xref: GO:0043725 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005895 name: 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl, IMG:01282] subset: gosubset_prok xref: EC:3.1.3.- xref: GO:0043726 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005896 name: 5-amino-4-imidazole carboxylate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate." [GOC:jl, IMG:01835] subset: gosubset_prok xref: EC:4.1.1.- xref: GO:0043727 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0005897 name: 2-keto-4-methylthiobutyrate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine." [GOC:jl, IMG:01683] subset: gosubset_prok xref: EC:4.1.1.- xref: GO:0043728 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0005898 name: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate." [GOC:jl, IMG:01536] subset: gosubset_prok xref: EC:4.-.-.- xref: GO:0043729 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0005899 name: 5-ureido-4-imidazole carboxylate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2." [GOC:jl, IMG:02121] subset: gosubset_prok xref: EC:3.5.3.- xref: GO:0043730 is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0005900 name: 6-hydroxynicotinate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591] subset: gosubset_prok xref: EC:1.14.13.- xref: GO:0043731 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005901 name: 6-hydroxynicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O." [EC:1.17.3.3] subset: gosubset_prok synonym: "6-hydroxynicotinate hydroxylase activity" EXACT [EC:1.17.3.3] synonym: "6-hydroxynicotinate:O2 oxidoreductase activity" EXACT [EC:1.17.3.3] synonym: "6-hydroxynicotinic acid dehydrogenase activity" EXACT [EC:1.17.3.3] synonym: "6-hydroxynicotinic acid hydroxylase activity" EXACT [EC:1.17.3.3] xref: EC:1.17.3.3 xref: GO:0043732 is_a: CCO:F0003309 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: CCO:F0005902 name: DNA-3-methyladenine glycosylase III activity namespace: molecular_function def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. This enzyme is unable to excise N-7-methylpurines or oxidized bases, such as hypoxanthine." [IMG:00576, PMID:10777493, PMID:14517230] subset: gosubset_prok synonym: "Mag III" NARROW [] synonym: "MagIII" NARROW [] xref: EC:3.2.2.- xref: GO:0043733 is_a: CCO:F0000410 ! alkylbase DNA N-glycosylase activity [Term] id: CCO:F0005903 name: DNA-N1-methyladenine dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methylgroup on N1-methyladenine and N3-methylcytosine as formaldehyde." [IMG:00579, UniProt:P05050] subset: gosubset_prok synonym: "AlkB" NARROW [] synonym: "alkB" NARROW [] synonym: "alpha-ketoglutarate-dependent dioxygenase" NARROW [] xref: EC:1.14.11.- xref: GO:0043734 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0005904 name: delta-9 acyl-phospholipid desaturase activity namespace: molecular_function subset: gosubset_prok synonym: "MpgII" NARROW [] xref: GO:0043735 is_a: CCO:F0003300 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: CCO:F0005905 name: DNA-3-methyladenine glycosylase IV activity namespace: molecular_function def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site." [IMG:00578, PMID:10375529] subset: gosubset_prok synonym: "Mpg II" NARROW [] synonym: "MpgII" NARROW [] xref: GO:0043736 is_a: CCO:F0000410 ! alkylbase DNA N-glycosylase activity [Term] id: CCO:F0005906 name: deoxyribonuclease V activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate." [EC:3.1.21.7] synonym: "DNase V activity" EXACT [EC:3.1.21.7] synonym: "endodeoxyribonuclease V" EXACT [] synonym: "endonuclease V activity" BROAD [EC:3.1.21.7] synonym: "Escherichia coli endodeoxyribonuclease V activity" NARROW [EC:3.1.21.7] xref: EC:3.1.21.7 xref: GO:0043737 is_a: CCO:F0003446 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005907 name: F420H2 dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: methanophenazine + reduced cofactor F420 = dihydromethanophenazine + cofactor F420." [MetaCyc:CPLX-7105] subset: gosubset_prok xref: EC:1.-.-.- xref: GO:0043738 xref: MetaCyc:CPLX-7105 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0005908 name: G/U mismatch-specific uracil-DNA glycosylase activity namespace: molecular_function def: "Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site." [IMG:00570, SP:O59825] subset: gosubset_prok synonym: "GU mismatch-specific uracil-DNA glycosylase activity" EXACT [] synonym: "MUG" EXACT [] synonym: "uracil mismatch repair protein" BROAD [] xref: GO:0043739 is_a: CCO:F0001200 ! uracil DNA N-glycosylase activity is_a: CCO:F0001804 ! pyrimidine-specific mismatch base pair DNA N-glycosylase activity [Term] id: CCO:F0005909 name: GTP cyclohydrolase IIa activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + 2 phosphate." [EC:3.5.4.29] subset: gosubset_prok synonym: "GTP 8,9-dihydrolase (phosphate-forming)" EXACT [EC:3.5.4.29] synonym: "GTP 8,9-hydrolase (phosphate-forming)" EXACT [] synonym: "GTP cyclohydrolase III activity" NARROW [EC:3.5.4.29] xref: EC:3.5.4.29 xref: GO:0043740 is_a: CCO:F0000428 ! GTP cyclohydrolase activity [Term] id: CCO:F0005910 name: L-2-aminoadipate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate + acetyl-CoA = N2-acetyl-L-aminoadipate + CoA." [IMG:01447] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0043741 is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0005911 name: LPPG:FO 2-phospho-L-lactate transferase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [IMG:01551] subset: gosubset_prok xref: EC:2.7.1.- xref: GO:0043743 is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0005912 name: N2-acetyl-L-aminoadipate kinase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate + ATP = N2-acetyl-L-aminoadipyl-delta-phosphate + ADP." [IMG:01448] subset: gosubset_prok xref: EC:2.7.2.- xref: GO:0043744 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0005913 name: N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate." [IMG:01449] subset: gosubset_prok xref: EC:1.2.1.- xref: GO:0043745 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005914 name: N2-acetyl-L-lysine aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine." [IMG:01450] subset: gosubset_prok synonym: "N-acetyl-lysine aminotransferase activity" EXACT [] xref: EC:2.6.1.- xref: GO:0043746 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0005915 name: N2-acetyl-L-lysine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine." [IMG:01451] subset: gosubset_prok synonym: "N-acetyl-lysine deacetylase activity" EXACT [] xref: EC:3.5.1.- xref: GO:0043747 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005916 name: O-succinylbenzoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate." [IMG:01733] subset: gosubset_prok xref: EC:3.5.1.- xref: GO:0043748 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005917 name: phenol, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate." [PMID:15547277] subset: gosubset_prok synonym: "ATP:phenol:water phosphotransferase activity" EXACT [] synonym: "phenol:water dikinase activity" EXACT [] synonym: "phenylphosphate synthase activity" EXACT [] xref: EC:2.7.9.- xref: GO:0043749 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003353 ! phosphotransferase activity, paired acceptors [Term] id: CCO:F0005918 name: phosphatidylinositol alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol." [EC:2.4.1.57] subset: gosubset_prok synonym: "GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57] xref: EC:2.4.1.57 xref: GO:0043750 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0005919 name: polyphosphate:AMP phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "PAP" EXACT [] synonym: "PPT" EXACT [] xref: EC:2.7.4.- xref: GO:0043751 is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0005920 name: adenosylcobinamide kinase activity namespace: molecular_function def: "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)." [EC:2.7.1.156] subset: gosubset_prok synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] synonym: "CobU" RELATED [] synonym: "RTP:adenosylcobinamide phosphotransferase activity" EXACT [] xref: EC:2.7.1.156 xref: GO:0043752 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0005921 name: adenosylcobinamide-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP." [EC:2.7.7.62] subset: gosubset_prok synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] synonym: "CobU" RELATED [] synonym: "GTP:adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] xref: EC:2.7.7.62 xref: GO:0043753 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0005922 name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168] subset: gosubset_prok synonym: "2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168] synonym: "2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168] synonym: "dihydrolipoyl transacylase activity" EXACT [EC:2.3.1.168] synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT [] xref: EC:2.3.1.168 xref: GO:0043754 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005923 name: alpha-ribazole phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate." [EC:3.1.3.73] subset: gosubset_prok synonym: "alpha-ribazole-5'-phosphate phosphohydrolase activity" EXACT [] synonym: "CobC" RELATED [] xref: EC:3.1.3.73 xref: GO:0043755 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0005924 name: adenosylcobinamide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol." [EC:3.5.1.90] subset: gosubset_prok synonym: "adenosylcobinamide amidohydrolase activity" EXACT [EC:3.5.1.90] synonym: "AdoCbi amidohydrolase activity" EXACT [EC:3.5.1.90] synonym: "AdoCbi hydrolase activity" EXACT [EC:3.5.1.90] synonym: "CbiZ" RELATED [] xref: EC:3.5.1.90 xref: GO:0043756 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0005925 name: adenosylcobinamide-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reactions: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate and (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide." [EC:6.3.1.10] subset: gosubset_prok synonym: "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)" EXACT [] synonym: "AdoCbi-P synthase activity" EXACT [EC:6.3.1.10] synonym: "CbiB" RELATED [] xref: EC:6.3.1.10 xref: GO:0043757 is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0005926 name: acetate-CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA." [EC:6.2.1.13] subset: gosubset_prok synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.13] synonym: "acetate--CoA ligase (ADP-forming) activity" EXACT [] synonym: "acetate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.13] synonym: "acetyl coenzyme A synthetase (adenosine diphosphate-forming)" EXACT [] synonym: "acetyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.13] xref: EC:6.2.1.13 xref: GO:0043758 is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0005927 name: branched-chain acyl-CoA synthetase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = ADP + orthophosphate + 2-methylbutanoyl-CoA." [IMG:01425] subset: gosubset_prok synonym: "branched chain acyl CoA synthetase (ADP-forming) activity" EXACT [] synonym: "branched chain acyl-CoA synthetase (ADP-forming) activity" EXACT [] synonym: "branched-chain acyl CoA synthetase (ADP-forming) activity" EXACT [] xref: EC:6.2.1.- xref: GO:0043759 is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0005928 name: acetyldiaminopimelate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate." [IMG:00444, PMID:1906065] subset: gosubset_prok synonym: "N-acetyl-diaminopimelate aminotransferase activity" EXACT [] synonym: "N-acetyl-L,L-diaminopimelate aminotransferase activity" EXACT [] xref: EC:2.6.1.- xref: GO:0043760 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0005929 name: archaetidylserine synthase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP." [IMG:01567, PMID:12562787] subset: gosubset_prok synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity" EXACT [] synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity" EXACT [] xref: EC:2.7.8.- xref: GO:0043761 is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0005930 name: aryl-CoA synthetase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phenylacetate + CoA = ADP + orthophosphate + phenylacetyl-CoA." [IMG:01427] subset: gosubset_prok xref: EC:6.2.1.- xref: GO:0043762 is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0005931 name: UTP:glucose-1-phosphate uridylyltransferase regulator activity namespace: molecular_function def: "Modulates the activity of UTP:glucose-1-phosphate uridylyltransferase." [GOC:jl] subset: gosubset_prok synonym: "glucose-1-phosphate uridylyltransferase regulator activity" EXACT [] synonym: "UDP-glucose diphosphorylase regulator activity" EXACT [] synonym: "UDP-glucose pyrophosphorylase regulator activity" EXACT [] xref: GO:0043763 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0005932 name: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein]." [IMG:00545, InterPro:IPR007691] subset: gosubset_prok xref: EC:2.3.1.- xref: GO:0043764 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005933 name: T/G mismatch-specific endonuclease activity namespace: molecular_function def: "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine." [IMG:00606, SP:P09184] subset: gosubset_prok synonym: "DNA mismatch endonuclease" BROAD [] synonym: "V.EcoKDcm" RELATED [] synonym: "very short patch repair protein" RELATED [] synonym: "Vsr mismatch endonuclease" RELATED [] xref: EC:3.1.-.- xref: GO:0043765 is_a: CCO:F0000916 ! endonuclease activity [Term] id: CCO:F0005934 name: Sep-tRNA:Cys-tRNA synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoseryl-tRNA(Cys) + H2S = cysteinyl-tRNA(Cys) + orthophosphate." [IMG:00235, PMID:15790858, PMID:16380427, PMID:17110438] subset: gosubset_prok synonym: "O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity" EXACT [] synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT [] synonym: "SepCysS" RELATED [] xref: EC:2.5.1.- xref: GO:0043766 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005935 name: pyrrolysyl-tRNA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + pyrophosphate + L-pyrrolysyl-tRNA(Pyl)." [IMG:02553, PMID:15314242, SP:Q8TUB8] subset: gosubset_prok synonym: " Pyrrolysine-tRNA ligase activity" EXACT [] synonym: "PylRS" EXACT [] xref: EC:6.1.1.- xref: GO:0043767 is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0005936 name: S-ribosylhomocysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione." [EC:4.4.1.21, IMG:02085] subset: gosubset_prok synonym: "3.2.1.148" RELATED [] synonym: "LuxS" RELATED [] synonym: "ribosylhomocysteinase activity" EXACT [] synonym: "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]" RELATED [EC:4.4.1.21] synonym: "S-ribosylhomocysteinase activity" EXACT [] xref: EC:4.4.1.21 xref: GO:0019138 xref: GO:0043768 xref: MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0005937 name: demethylmenaquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine." [IMG:01848] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0043770 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005938 name: cytidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cytidine = ADP + CMP." [IMG:01870] subset: gosubset_prok xref: EC:2.7.1.- xref: GO:0043771 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0005939 name: acyl-phosphate glycerol-3-phosphate acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate." [IMG:01872, PMID:17308305] subset: gosubset_prok synonym: "acyl-phosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "acylphosphate glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "acylphosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] xref: GO:0043772 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0005940 name: coenzyme F420-0 gamma-glutamyl ligase activity namespace: molecular_function def: "Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates, i.e. GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1 followed by GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2." [IMG:01552, UniProt:Q58178] subset: gosubset_prok synonym: "F420-0 gamma-glutamyl ligase activity" EXACT [] xref: EC:6.3.2.- xref: GO:0043773 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0005941 name: coenzyme F420-2 alpha-glutamyl ligase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate." [IMG:01553] subset: gosubset_prok synonym: "F420-2 alpha-glutamyl ligase activity" EXACT [] xref: EC:6.3.2.- xref: GO:0043774 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0005942 name: cobyrinate a,c-diamide synthase activity namespace: molecular_function def: "Catalysis of the reaction: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 orthophosphate." [IMG:01814] subset: gosubset_prok synonym: "cobyrinate a c diamide synthase activity" EXACT [] synonym: "cobyrinate a c-diamide synthase activity" EXACT [] synonym: "cobyrinate a,c diamide synthase activity" EXACT [] xref: EC:6.3.5.- xref: GO:0043775 is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0005943 name: cobalt-precorrin-6B C5-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7." [IMG:02115, MetaCyc:RXN-8766] subset: gosubset_prok synonym: "cobalt-precorrin 6B C5-methyltransferase activity" EXACT [] synonym: "precorrin-6 methyltransferase activity" EXACT [] synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] synonym: "precorrin-6Y methylase" BROAD [] xref: EC:2.1.1.- xref: GO:0043776 xref: MetaCyc:RXN-8766 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005944 name: cobalt-precorrin-7 C15-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." [IMG:02116, MetaCyc:RXN-8767] subset: gosubset_prok synonym: "cobalt-precorrin 7 C15-methyltransferase activity" EXACT [] synonym: "precorrin-6 methyltransferase" BROAD [] synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] synonym: "precorrin-6Y methylase" BROAD [] xref: EC:2.1.1.- xref: GO:0043777 xref: MetaCyc:RXN-8767 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005945 name: cobalt-precorrin-8 methylmutase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate." [IMG:02117, MetaCyc:RXN-8768] subset: gosubset_prok synonym: "cobalt-precorrin 8 methylmutase activity" EXACT [] synonym: "cobalt-precorrin 8X methylmutase activity" EXACT [] synonym: "cobalt-precorrin-8X methylmutase activity" EXACT [] xref: EC:5.4.1.- xref: GO:0043778 xref: MetaCyc:RXN-8768 is_a: CCO:F0003428 ! intramolecular transferase activity, transferring acyl groups [Term] id: CCO:F0005946 name: cobalt-precorrin-5A acetaldehyde-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde." [IMG:02112, MetaCyc:RXN-8763] subset: gosubset_prok synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT [] xref: GO:0043779 xref: MetaCyc:RXN-8763 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0005947 name: cobalt-precorrin-5B C1-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [IMG:02112, MetaCyc:RXN-8764] subset: gosubset_prok synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: GO:0043780 xref: MetaCyc:RXN-8764 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005948 name: cobalt-factor II C20-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III." [EC:2.1.1.151, IMG:01812] subset: gosubset_prok synonym: "CbiL" NARROW [] synonym: "cobalt-factor II C20 methyltransferase activity" EXACT [] synonym: "cobalt-precorrin-2 C(20)-methyltransferase activity" EXACT [EC:2.1.1.151] synonym: "S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity" EXACT [EC:2.1.1.151] xref: EC:2.1.1.151 xref: GO:0043781 xref: MetaCyc:RXN-8760 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005949 name: cobalt-precorrin-3 C17-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine." [IMG:02110, MetaCyc:RXN-8761, UniProt:Q05590] subset: gosubset_prok synonym: "cobalt-precorrin 3 C17-methyltransferase activity" EXACT [] synonym: "cobalt-precorrin-3 methylase" BROAD [] synonym: "cobalt-precorrin-3 methyltransferase" BROAD [] synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: GO:0043782 xref: MetaCyc:RXN-8761 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005950 name: oxidoreductase activity, oxidizing metal ions with flavin as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor." [EC:1.16.8] subset: gosubset_prok xref: EC:1.16.8 xref: GO:0043783 is_a: CCO:F0003304 ! oxidoreductase activity, oxidizing metal ions [Term] id: CCO:F0005951 name: cob(II)yrinic acid a,c-diamide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(II)yrinic acid a,c-diamide + FMN = 2 cob(I)yrinic acid a,c-diamide + FMNH2." [EC:1.16.8.1] subset: gosubset_prok synonym: "cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity" EXACT [] xref: EC:1.16.8.1 xref: GO:0043784 is_a: CCO:F0005950 ! oxidoreductase activity, oxidizing metal ions with flavin as acceptor [Term] id: CCO:F0005952 name: cinnamoyl-CoA:phenyllactate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-cinnamoyl-CoA + (R)-phenyllactate = (E)-cinnamate + (R)-phenyllactyl-CoA." [EC:2.8.3.17] subset: gosubset_prok synonym: "(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity" EXACT [] synonym: "FldA" RELATED [] xref: EC:2.8.3.17 xref: GO:0043785 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0005953 name: cinnamate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+." [EC:1.3.1.-, IMG:01615, PMID:10849007] subset: gosubset_prok xref: EC:1.3.1.- xref: GO:0043786 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005954 name: chlorophyll synthase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide a + phytyl diphosphate = chlorophyll a + diphosphate." [EC:2.5.1.62, IMG:01750] subset: gosubset_prok synonym: "chlorophyllide-a:phytyl-diphosphate phytyltransferase activity" EXACT [] xref: EC:2.5.1.62 xref: GO:0043787 is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0005955 name: cardiolipin synthetase 2 activity namespace: molecular_function def: "Catalysis of the reaction: 2 1,2-diacyl-sn-glycero-3-[phospho-rac-(1-glycerol)] = cardiolipin + glycerol." [IMG:00156] subset: gosubset_prok synonym: "cardiolipin synthase 2 activity" EXACT [] xref: EC:2.7.8.- xref: GO:0043788 is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0005956 name: diguanylate cyclase activity namespace: molecular_function def: "Catalysis of the conversion of 2GTP to bis-(3'-5')cyclic guanylic acid, via linear diguanosine tetraphosphate pppg 3'p5'g, releasing 1 pyrophosphate at each step." [http://cancerweb.ncl.ac.uk/, IMG:02393, PMID:16895465] subset: gosubset_prok xref: EC:4.6.1.- xref: GO:0043789 is_a: CCO:F0003413 ! phosphorus-oxygen lyase activity [Term] id: CCO:F0005957 name: dimethyladenosine transferase activity namespace: molecular_function def: "Catalysis of the dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle." [IMG:02532, UniProt:Q6C7H6] subset: gosubset_prok synonym: "18S rRNA dimethylase activity" EXACT [] synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: GO:0043790 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005958 name: dimethylamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine." [IMG:01321, MetaCyc:RXN-8100, PMID:9874228, UniProt:O93661] comment: This function is the first step in the pathway of methanogenesis from dimethylamine. subset: gosubset_prok synonym: "dimethylamine:corrinoid methyltransferase activity" EXACT [] synonym: "DMA methyltransferase 1" EXACT [] synonym: "DMAMT 1" EXACT [] synonym: "MT1" BROAD [] synonym: "mtbB1" RELATED [] xref: EC:2.1.1.- xref: GO:0043791 xref: MetaCyc:RXN-8100 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005959 name: enamidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O = 2-formylglutarate + NH." [EC:3.5.2.18] subset: gosubset_prok synonym: "6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity" EXACT [] xref: EC:3.5.2.18 xref: GO:0043792 is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0005960 name: beta-ribofuranosylaminobenzene 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + pyrophosphate." [GOC:jl, IMG:01544, PMID:12142414] subset: gosubset_prok synonym: "beta-RFAP synthase activity" EXACT [] xref: GO:0043793 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0005961 name: formate dehydrogenase (F420) activity namespace: molecular_function def: "Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420." [IMG:01432, PMID:3801411] subset: gosubset_prok xref: EC:1.2.99.- xref: GO:0043794 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0005962 name: glyceraldehyde oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor." [IMG:01506] subset: gosubset_prok xref: EC:1.2.-.-. xref: GO:0043795 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0005963 name: glyceraldehyde dehydrogenase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [IMG:01555] subset: gosubset_prok xref: EC:1.2.1.- xref: GO:0043796 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005964 name: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.6] subset: gosubset_prok synonym: "D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity" EXACT [] synonym: "GAPOR" RELATED [] synonym: "glyceraldehyde-3-phosphate Fd oxidoreductase activity" EXACT [EC:1.2.7.6] synonym: "glyceraldehyde-3-phosphate ferredoxin reductase activity" EXACT [EC:1.2.7.6] xref: EC:1.2.7.6 xref: GO:0043797 is_a: CCO:F0003227 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0005965 name: glycerate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP." [IMG:01510, PMID:14413719, Reactome:GKI-RXN] subset: gosubset_prok synonym: "D-glycerate 2-kinase activity" EXACT [] synonym: "glycerate kinase" BROAD [] xref: EC:2.7.1.- xref: GO:0043798 xref: MetaCyc:GKI-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003257 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: CCO:F0005966 name: glycine oxidase activity namespace: molecular_function def: "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + H2O2 (2) D-alanine + H2O + O2 = pyruvate + NH3 + H2O2 (3) sarcosine + H2O + O2 = glyoxylate + methylamine + H2O2 (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + H2O2." [EC:1.4.3.19] subset: gosubset_prok synonym: "glycine:oxygen oxidoreductase (deaminating)" EXACT [] xref: EC:1.4.3.19 xref: GO:0043799 is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0005967 name: hexulose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate." [IMG:01502, UniProt:P44990] subset: gosubset_prok synonym: "HUMPI" EXACT [] xref: EC:5.-.-.- xref: GO:0043800 is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0005968 name: hexulose-6-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate." [IMG:01503, UniProt:Q5WCM6] subset: gosubset_prok xref: EC:4.1.2.- xref: GO:0043801 is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0005969 name: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate." [EC:6.3.5.9] subset: gosubset_prok synonym: "CobB" RELATED [] synonym: "hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity" EXACT [] synonym: "hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)" EXACT [] xref: EC:6.3.5.9 xref: GO:0043802 is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0005970 name: hydroxyneurosporene-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = spheroidene + S-adenosyl-L-homocysteine." [IMG:01759] subset: gosubset_prok xref: EC:2.1.1.- xref: GO:0043803 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005971 name: imidazolone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-formiminoglycine = imidazolone + H2O." [IMG:02122] subset: gosubset_prok xref: EC:3.5.2.- xref: GO:0043804 is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0005972 name: indolepyruvate ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.8] subset: gosubset_prok synonym: "3-(indol-3-yl)pyruvate synthase (ferredoxin) activity" EXACT [EC:1.2.7.8] synonym: "3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)" EXACT [EC:1.2.7.8] synonym: "indolepyruvate oxidoreductase activity" EXACT [EC:1.2.7.8] synonym: "IOR" RELATED [] xref: EC:1.2.7.8 xref: GO:0043805 is_a: CCO:F0003227 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0005973 name: keto acid formate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate." [IMG:00725, UniProt:P42632] subset: gosubset_prok synonym: "keto-acid formate acetyltransferase" BROAD [] synonym: "keto-acid formate lyase activity" EXACT [] synonym: "keto-acid formate-lyase activity" EXACT [] xref: EC:2.3.1.- xref: GO:0043806 is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0005974 name: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.7] subset: gosubset_prok synonym: "2-ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] synonym: "2-oxoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] synonym: "3-methyl-2-oxobutanoate synthase (ferredoxin) activity" EXACT [EC:1.2.7.7] synonym: "3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)" EXACT [] synonym: "branched-chain ketoacid ferredoxin reductase activity" RELATED [EC:1.2.7.7] synonym: "branched-chain oxo acid ferredoxin reductase activity" RELATED [EC:1.2.7.7] synonym: "keto-valine-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.7] synonym: "ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] synonym: "ketoisovalerate oxidoreductase activity" EXACT [EC:1.2.7.7] synonym: "VOR" RELATED [] xref: EC:1.2.7.7 xref: GO:0043807 is_a: CCO:F0003227 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0005975 name: lyso-ornithine lipid acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl carrier protein] = ornithine lipid + [acyl carrier protein]." [IMG:02097, PMID:15341653] subset: gosubset_prok xref: GO:0043808 is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0005976 name: methylthioribulose 1-phosphate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O." [EC:4.2.1.109] subset: gosubset_prok synonym: "1-PMT-ribulose dehydratase activity" EXACT [EC:4.2.1.109] synonym: "methylthioribulose-1-phosphate dehydratase activity" EXACT [] synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" RELATED [EC:4.2.1.109] synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity" EXACT [] synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" EXACT [] xref: EC:4.2.1.109 xref: GO:0043809 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0005977 name: ornithine-acyl [acyl carrier protein] N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl carrier protein]." [IMG:02096] subset: gosubset_prok synonym: "ornithine-acyl[acyl carrier protein] N-acyltransferase activity" EXACT [] xref: GO:0043810 is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0005978 name: phosphate:acyl-[acyl carrier protein] acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl carrier protein] + orthophosphate = acyl phosphate + [acyl carrier protein]." [IMG:01871] subset: gosubset_prok xref: GO:0043811 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0005979 name: phosphatidylinositol-4-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [IMG:01360] subset: gosubset_prok synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT [] xref: EC:3.1.3.- xref: GO:0043812 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity [Term] id: CCO:F0005980 name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidyInositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [IMG:01359, UniProt:P42837] subset: gosubset_prok synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT [] xref: EC:3.1.3.- xref: GO:0043813 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity [Term] id: CCO:F0005981 name: phospholactate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + pyrophosphate." [IMG:01547] subset: gosubset_prok xref: EC:2.7.7.- xref: GO:0043814 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0005982 name: phosphoribosylglycinamide formyltransferase 2 activity namespace: molecular_function def: "Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate." [IMG:01297, UniProt:P33221] subset: gosubset_prok synonym: "5'-phosphoribosylglycinamide transformylase 2" EXACT [] synonym: "formate-dependent GAR transformylase activity" EXACT [] synonym: "GAR transformylase 2" RELATED [] synonym: "GART 2" RELATED [] xref: EC:2.1.2.- xref: GO:0043815 is_a: CCO:F0003318 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: CCO:F0005983 name: phosphoserine-tRNA(Cys) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + pyrophosphate + phosphoseryl-tRNA(Cys)." [IMG:00622, PMID:17110438] subset: gosubset_prok synonym: "O-phosphoseryl-tRNA(Cys) synthetase activity" EXACT [] synonym: "phosphoserine--tRNA(Cys) ligase activity" EXACT [] synonym: "phosphoserine-tRNACys ligase activity" EXACT [] synonym: "SepRS" RELATED [] xref: EC:6.1.1.- xref: GO:0043816 is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0005984 name: phosphosulfolactate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = sulfite + phosphoenolpyruvate." [IMG:00622] subset: gosubset_prok synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.4.1.19] synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase activity" EXACT [] synonym: "(2R)-phospho-3-sulfolactate synthase activity" EXACT [EC:4.4.1.19] synonym: "PSL synthase activity" EXACT [EC:4.4.1.19] xref: EC:4.4.1.19 xref: GO:0043817 is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0005985 name: precorrin-3B synthase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O." [IMG:01805] subset: gosubset_prok synonym: "CobG" RELATED [] synonym: "precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)" EXACT [] synonym: "precorrin-3X synthase activity" EXACT [EC:1.14.13.83] xref: EC:1.14.13.83 xref: GO:0043818 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0005986 name: precorrin-6A synthase (deacetylating) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate." [EC:2.1.1.152, IMG:01802] subset: gosubset_prok synonym: "CobF" RELATED [] synonym: "precorrin-6X synthase (deacetylating) activity" EXACT [EC:2.1.1.152] synonym: "S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)" EXACT [] xref: EC:2.1.1.152 xref: GO:0043819 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0005987 name: propionyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA." [PMID:12603323] subset: gosubset_prok xref: EC:1.3.99.- xref: GO:0043820 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0005988 name: propionyl-CoA:succinate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate." [IMG:01589, MetaCyc:RXN0-268] subset: gosubset_prok synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT [] synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT [] xref: EC:2.8.3.- xref: GO:0043821 xref: MetaCyc:RXN0-268 is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0005989 name: ribonuclease M5 activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor." [EC:3.1.26.8, IMG:02522] subset: gosubset_prok synonym: "5S ribosomal maturation nuclease activity" EXACT [EC:3.1.26.8] synonym: "5S ribosomal RNA maturation endonuclease activity" EXACT [] synonym: "RNase M5 activity" EXACT [EC:3.1.26.8] xref: EC:3.1.26.8 xref: GO:0043822 is_a: CCO:F0003449 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: CCO:F0005990 name: spheroidene monooxygenase activity namespace: molecular_function def: "Catalysis of the conversion of spheroidene to spheroidenone." [IMG:01761, PMID:16086104, PMID:16158287] subset: gosubset_prok xref: EC:1.14.-.- xref: GO:0043823 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0005991 name: succinylglutamate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH + 2 H+." [EC:1.2.1.71, IMG:00484] subset: gosubset_prok synonym: "AruD" RELATED [] synonym: "AstD" RELATED [] synonym: "N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.71] synonym: "N-succinylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71] synonym: "SGSD" RELATED [] synonym: "succinyl glutamate-semialdehyde dehydrogenase activity" EXACT [] synonym: "succinylglutamic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71] xref: EC:1.2.1.71 xref: GO:0043824 xref: MetaCyc:SUCCGLUALDDEHYD-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0005992 name: succinylornithine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: N2-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.81, IMG:00483] subset: gosubset_prok synonym: "2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.81] synonym: "AstC" RELATED [] synonym: "N(2)-succinylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.81] synonym: "N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [] synonym: "N2-succinylornithine 5-aminotransferase activity" EXACT [] synonym: "SOAT" RELATED [] synonym: "succinyl ornithine transaminase activity" EXACT [] synonym: "succinyl-ornithine transaminase activity" EXACT [EC:2.6.1.81] synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.81] xref: EC:2.6.1.81 xref: GO:0043825 xref: MetaCyc:SUCCORNTRANSAM-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0005993 name: sulfur oxygenase reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5 S0 + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide." [IMG:00713, MetaCyc:RXN-8226, PMID:1522063] subset: gosubset_prok synonym: "SOR" RELATED [] synonym: "sulphur oxygenase reductase activity" EXACT [] xref: EC:1.-.-.- xref: GO:0043826 xref: MetaCyc:RXN-8226 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0005994 name: tRNA (adenine-57, 58-N(1)-) methyltransferase activity namespace: molecular_function def: "Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA." [IMG:00706, PMID:14739239] subset: gosubset_prok synonym: "TrmI" RELATED [] synonym: "tRNA (adenine-57, 58 N1-) methyltransferase activity" EXACT [] synonym: "tRNA (adenine-57, 58-N1-) methyltransferase activity" EXACT [] synonym: "tRNA (m1A) MTase" BROAD [] xref: EC:2.1.1.- xref: GO:0043827 is_a: CCO:F0003151 ! tRNA (adenine-N1-)-methyltransferase activity [Term] id: CCO:F0005995 name: tRNA 2-selenouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)." [IMG:02609, MetaCyc:RXN0-2281, UniProt:Q8Z8R4] subset: gosubset_prok synonym: "B0503" RELATED [] synonym: "SelU" RELATED [] synonym: "YbbB" RELATED [] xref: EC:2.9.1.- xref: GO:0043828 xref: MetaCyc:RXN0-2281 is_a: CCO:F0003358 ! selenotransferase activity [Term] id: CCO:F0005996 name: tRNA-specific adenosine-37 deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [IMG:00703, UniProt:P53065] subset: gosubset_prok synonym: "TAD1" RELATED [] synonym: "tRNA(Ala)-A37 deaminase activity" EXACT [] synonym: "tRNA-specific adenosine deaminase 1" EXACT [] xref: EC:3.5.4.- xref: GO:0043829 is_a: CCO:F0001794 ! tRNA-specific adenosine deaminase activity [Term] id: CCO:F0005997 name: thiol-driven fumarate reductase activity namespace: molecular_function def: "Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide." [IMG:01366, PMID:2509466] subset: gosubset_prok xref: EC:1.3.99.- xref: GO:0043830 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0005998 name: thiosulfate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: 2 thiosulfate + 2 6-decylubiquinone = tetrathionate + 2 6-decylubiquinol." [EC:1.8.5.2, IMG:00714, MetaCyc:1.8.5.2-RXN] subset: gosubset_prok synonym: "DoxA" RELATED [] synonym: "DoxD" RELATED [] synonym: "thiosulfate oxidoreductase, tetrathionate-forming activity" EXACT [EC:1.8.5.2] synonym: "thiosulfate:6-decylubiquinone oxidoreductase activity" EXACT [EC:1.8.5.2] synonym: "thiosulfate:quinone oxidoreductase activity" EXACT [EC:1.8.5.2] synonym: "thiosulphate dehydrogenase (quinone) activity" EXACT [] synonym: "thiosulphate:quinone oxidoreductase activity" EXACT [] synonym: "TQO" RELATED [] xref: EC:1.8.5.2 xref: GO:0043831 xref: MetaCyc:1.8.5.2-RXN is_a: CCO:F0003265 ! oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor [Term] id: CCO:F0005999 name: trans-2, cis-3 decenoyl-ACP isomerase activity namespace: molecular_function def: "Catalysis of the isomerization of trans-2-decenoyl-ACP to cis-3-decenoyl-ACP." [IMG:02508, PMID:12237320] subset: gosubset_prok synonym: "trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity" EXACT [] xref: EC:5.3.3.- xref: GO:0043832 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0006000 name: methylamine-specific methylcobalamin:coenzyme M methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01318, MetaCyc:RXN-8099, UniProt:P58984] comment: This function is the second step in the pathway of methanogenesis from monomethylamine, dimethylamine and trimethylamine. subset: gosubset_prok synonym: "dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] synonym: "methylamine-specific methylcobalamin:CoM methyltransferase activity" EXACT [] synonym: "methylcobamide:coenzyme M methyltransferase activity" EXACT [] synonym: "methylcobamide:CoM methyltransferase activity" EXACT [] synonym: "methylcobamide:CoM methyltransferase II isozyme A" RELATED [] synonym: "monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] synonym: "MT2" BROAD [] synonym: "MT2-A" RELATED [] synonym: "MtbA" RELATED [] synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] xref: EC:2.1.1.- xref: GO:0043833 xref: MetaCyc:RXN-8099 xref: MetaCyc:RXN-8101 xref: MetaCyc:RXN-8103 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0006001 name: trimethylamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine." [IMG:01323, MetaCyc:RXN-8102, UniProt:Q8TTA9] comment: This function is the first step in the pathway of methanogenesis from trimethylamine. subset: gosubset_prok synonym: "MT1" BROAD [] synonym: "mttB1" RELATED [] synonym: "TMA methyltransferase 1" EXACT [] synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: GO:0043834 xref: MetaCyc:RXN-8102 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0006002 name: uracil/thymine dehydrogenase activity namespace: molecular_function def: "Catalyzes the reactions: (1) uracil + H2O + acceptor = barbiturate + reduced acceptor (2) thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor." [EC:1.17.99.4, IMG:01821] subset: gosubset_prok synonym: "uracil oxidase activity" RELATED [EC:1.17.99.4] synonym: "uracil-thymine oxidase activity" EXACT [EC:1.17.99.4] synonym: "uracil:acceptor oxidoreductase activity" EXACT [] xref: EC:1.17.99.4 xref: GO:0043835 is_a: CCO:F0003307 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: CCO:F0006003 name: xanthine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate." [IMG:01834, MetaCyc:R127-RXN] subset: gosubset_prok synonym: "xanthinase activity" EXACT [] xref: EC:3.5.2.- xref: GO:0043836 xref: MetaCyc:R127-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0006004 name: valine dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH." [IMG:00766, UniProt:O69056] subset: gosubset_prok synonym: "ValDH" RELATED [] xref: EC:1.4.1.- xref: GO:0043837 is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006005 name: phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity namespace: molecular_function def: "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol." [IMG:00182, PMID:15795227] comment: Note that Kdo is an abbreviation for 3-deoxy-D-manno-oct-2-ulosonic acid. subset: gosubset_prok synonym: "EptB" RELATED [] synonym: "phosphoethanolamine transferase" BROAD [] xref: GO:0043838 is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006006 name: lipid A phosphate methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate moiety of lipid A." [IMG:02094, PMID:15994324, UniProt:Q4FAC7] subset: gosubset_prok synonym: "lipid A 1-phosphomethyltransferase activity" EXACT [] synonym: "lipid A methyltransferase" BROAD [] synonym: "lipid A phosphomethyltransferase activity" EXACT [] synonym: "LmtA" RELATED [] xref: GO:0043839 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0006007 name: branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine." [IMG:01684, PMID:12670965] subset: gosubset_prok synonym: "BCAT" RELATED [] synonym: "branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] synonym: "branched-chain amino acid aminotransferase" BROAD [] synonym: "branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] xref: EC:2.6.1.- xref: GO:0043840 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006009 name: Kdo transferase activity namespace: molecular_function def: "Catalysis of the reactions: (1) (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP (2) lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP." [IMG:00549, PMID:1577828, PMID:2033061, PMID:9195966] subset: gosubset_prok synonym: "3-deoxy-D-manno-octulosonic-acid transferase activity" EXACT [] synonym: "kdtA" RELATED [] synonym: "WaaA" RELATED [] xref: EC:2.-.-.- xref: GO:0043842 xref: MetaCyc:KDOTRANS-RXN xref: MetaCyc:KDOTRANS2-RXN is_a: CCO:F0003316 ! transferase activity [Term] id: CCO:F0006010 name: ADP-specific glucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147, IMG:01468] subset: gosubset_prok synonym: "ADP-dependent glucokinase activity" EXACT [EC:2.7.1.147] synonym: "ADP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.147] xref: EC:2.7.1.147 xref: GO:0043843 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006011 name: ADP-specific phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate." [EC:2.7.1.146, IMG:01469] subset: gosubset_prok synonym: "ADP-6-phosphofructokinase activity" EXACT [EC:2.7.1.146] synonym: "ADP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.146] synonym: "ADP-Pfk activity" EXACT [EC:2.7.1.146] synonym: "ADP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.146] xref: EC:2.7.1.146 xref: GO:0043844 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006012 name: excinuclease cho activity namespace: molecular_function def: "Catalyzes the incision of the DNA at the 3' side of a lesion." [IMG:00499, UniProt:P59439] comment: Note that this function occurs as part of nucleotide excision repair (NER). subset: gosubset_prok synonym: "cho" RELATED [] synonym: "endonuclease cho" EXACT [] synonym: "uvrc homolog protein" RELATED [] xref: GO:0043848 is_a: CCO:F0003448 ! site-specific endodeoxyribonuclease activity, specific for altered base [Term] id: CCO:F0006013 name: Ras palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins." [IMG:00473, UniProt:Q4I2M7] subset: gosubset_prok synonym: "DHHC cysteine-rich domain-containing protein ERF2" RELATED [] synonym: "ERF2" RELATED [] synonym: "palmitoyltransferase ERF2" RELATED [] synonym: "Ras protein acyltransferase activity" EXACT [] xref: EC:2.3.1.- xref: GO:0043849 is_a: CCO:F0003132 ! palmitoyltransferase activity [Term] id: CCO:F0006014 name: methanol-specific methylcobalamin:coenzyme M methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the methyl group from the methylated corrinoid cofactor of a methanol corrinoid protein to coenzyme M." [IMG:01315, MetaCyc:RXN-8096] comment: This function is the second step in the pathway of methanogenesis from methanol. subset: gosubset_prok synonym: "methanol-specific methylcobalamin: coenzyme M methyltransferase activity" EXACT [] synonym: "methanol-specific methylcobalamin:CoM methyltransferase activity" EXACT [] synonym: "methyltransferase 2" BROAD [] synonym: "MT2" BROAD [] synonym: "MtaA" RELATED [] synonym: "MtaC protein: coenzyme M methyltransferase activity" EXACT [] synonym: "MtaC protein:coenzyme M methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: GO:0043851 xref: MetaCyc:RXN-8096 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0006015 name: monomethylamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + ammonia." [IMG:01319, MetaCyc:RXN-8098] comment: This function is the first step in the pathway of methanogenesis from monomethylamine. subset: gosubset_prok synonym: "MMAMT" RELATED [] synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT [] synonym: "MtmB" RELATED [] xref: EC:2.1.1.- xref: GO:0043852 xref: MetaCyc:RXN-8098 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0006016 name: cyclic nucleotide-gated mechanosensitive ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl, IMG:02416] subset: gosubset_prok synonym: "cyclic nucleotide gated mechanosensitive ion channel activity" EXACT [] synonym: "cyclic nucleotide regulated mechanosensitive ion channel" EXACT [] synonym: "cyclic nucleotide-regulated mechanosensitive ion channel" EXACT [] synonym: "cyclic nucleotide-regulated small mechanosensitive ion channel" RELATED [] synonym: "MscS" RELATED [] synonym: "small conductance mechanosensitive ion channel" EXACT [] xref: GO:0043854 is_a: CCO:F0001855 ! mechanically-gated ion channel activity is_a: CCO:F0006017 ! cyclic nucleotide-gated ion channel activity [Term] id: CCO:F0006017 name: cyclic nucleotide-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl] subset: gosubset_prok synonym: "cyclic nucleotide activated ion channel activity" EXACT [] synonym: "cyclic nucleotide gated ion channel activity" EXACT [] synonym: "cyclic nucleotide-activated ion channel activity" EXACT [] xref: GO:0043855 is_a: CCO:F0002733 ! ligand-gated ion channel activity [Term] id: CCO:F0006018 name: anti-sigma factor antagonist activity namespace: molecular_function def: "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity." [GOC:jl, PMID:15576799] subset: gosubset_prok synonym: "anti-anti-sigma factor activity" EXACT [] xref: GO:0043856 is_a: CCO:F0004454 ! transcription regulator activity [Term] id: CCO:F0006019 name: N-acetylornithine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline." [EC:2.1.3.9] subset: gosubset_prok synonym: "acetylornithine transcarbamylase activity" EXACT [] synonym: "AOTC" RELATED [] synonym: "carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9] synonym: "carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9] synonym: "N-acetylornithine transcarbamylase activity" EXACT [] xref: EC:2.1.3.9 xref: GO:0043857 is_a: CCO:F0003319 ! carboxyl- or carbamoyltransferase activity [Term] id: CCO:F0006020 name: arginine:ornithine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)." [GOC:jl, PMID:17110979] subset: gosubset_prok synonym: "ArcD" RELATED [] synonym: "arginine-ornithine antiporter activity" EXACT [] synonym: "arginine/ornithine antiporter" EXACT [] xref: GO:0043858 is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0006021 name: cyanophycinase activity namespace: molecular_function def: "Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200, UniProt:P58562] subset: gosubset_prok xref: EC:3.-.-.- xref: GO:0043859 is_a: CCO:F0001786 ! serine-type peptidase activity [Term] id: CCO:F0006022 name: cyanophycin synthetase activity namespace: molecular_function def: "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)." [GOC:jl, UniProt:P58572] subset: gosubset_prok synonym: "cphA" RELATED [] xref: EC:6.-.-.- xref: GO:0043860 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0006023 name: agmatine:putrescine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)." [GOC:jl, PMID:17028272] subset: gosubset_prok synonym: "agmatine-putrescine antiporter activity" EXACT [] synonym: "agmatine/putrescine antiporter" EXACT [] xref: GO:0043861 is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0006024 name: arginine:agmatine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)." [GOC:jl, PMID:17099215] subset: gosubset_prok synonym: "AdiC" RELATED [] synonym: "arginine-agmatine antiporter activity" EXACT [] synonym: "arginine-agmatine exchange transporter" EXACT [] synonym: "arginine/agmatine antiporter activity" EXACT [] xref: GO:0043862 is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0006025 name: 4-hydroxy-2-ketopimelate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate." [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN, UniProt:Q46983] subset: gosubset_prok synonym: "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity" EXACT [] synonym: "HHED aldolase activity" EXACT [] synonym: "HpaI" RELATED [] synonym: "HpcH" RELATED [] xref: EC:4.1.2.- xref: GO:0043863 xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006026 name: indoleacetamide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetamide (IAM) + H2O = indole-3-acetate (IAA) + NH3." [GOC:jl, MetaCyc:RXNN-404, UniProt:Q04557] subset: gosubset_prok synonym: "IaaH" RELATED [] synonym: "IAH" EXACT [] synonym: "indole acetamide hydrolase activity" EXACT [] synonym: "indole-3-acetamide hydrolase activity" EXACT [] synonym: "Tms2" RELATED [] xref: EC:3.5.1.- xref: GO:0043864 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006027 name: methionine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of methionine from one side of a membrane to the other." [GOC:jl] subset: gosubset_prok xref: GO:0043865 is_a: CCO:F0000019 ! sulfur amino acid transmembrane transporter activity [Term] id: CCO:F0006028 name: adenylyl-sulfate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin." [EC:1.8.4.10] subset: gosubset_prok synonym: "AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [] synonym: "AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.10] synonym: "thioredoxin-dependent 5'-adenylylsulfate reductase activity" EXACT [] xref: EC:1.8.4.10 xref: GO:0043866 is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0006029 name: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine." [PMID:16407303, UniProt:Q9YAC2] subset: gosubset_prok synonym: "archaeal tRNA-guanine transglycosylase activity" EXACT [] synonym: "archaeosine tRNA-ribosyltransferase activity" EXACT [] synonym: "TgtA" RELATED [] xref: EC:2.4.2.- xref: GO:0043867 is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0006030 name: N-acetylaminoadipate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate." [PMID:10613839, UniProt:Q9V1I5] subset: gosubset_prok synonym: "acetylaminoadipate kinase activity" EXACT [] synonym: "LysZ" RELATED [] synonym: "N-acetyl-L-aminoadipate 5-phosphotransferase activity" EXACT [] xref: EC:2.7.2.- xref: GO:0043868 xref: MetaCyc:RXN-5182 is_a: CCO:F0003114 ! kinase activity [Term] id: CCO:F0006031 name: alpha-aminoadipate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A." [MetaCyc:RXN-5181, PMID:10613839, PMID:12925802] subset: gosubset_prok synonym: "lysine biosynthesis protein" RELATED [] synonym: "LysX" RELATED [] synonym: "RimK" RELATED [] xref: GO:0043869 xref: MetaCyc:RXN-5181 is_a: CCO:F0003130 ! acetyltransferase activity [Term] id: CCO:F0006032 name: N-acetyl-gamma-aminoadipyl-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP(+) + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH." [MetaCyc:RXN-5183, UniProt:Q9ZND6] comment: This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway. subset: gosubset_prok synonym: "AGPR" RELATED [] synonym: "ArgC" RELATED [] synonym: "LysY" RELATED [] synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT [] synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT [] synonym: "NAGSA dehydrogenase activity" BROAD [] xref: EC:1.2.1.- xref: GO:0043870 xref: MetaCyc:RXN-5183 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006033 name: delta1-piperideine-6-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-pipecolate = delta1-piperideine-6-carboxylate + 2 H+." [MetaCyc:RXN-8161, PMID:16237033] comment: This function is part of the pipecolate pathway of lysine catabolism. subset: gosubset_prok synonym: "AmaB" RELATED [] synonym: "delta 1-piperideine-6-carboxylate dehydrogenase activity" EXACT [] synonym: "delta-1-piperideine-6-carboxylate dehydrogenase activity" EXACT [] synonym: "PIPOX" RELATED [] xref: GO:0043871 xref: MetaCyc:RXN-8161 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0006034 name: lysine:cadaverine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)." [GOC:jl, PMID:10986235, UniProt:P0AAF0] subset: gosubset_prok synonym: "CadB" RELATED [] synonym: "lysine-cadaverine antiporter activity" EXACT [] synonym: "lysine/cadaverine antiporter activity" EXACT [] xref: GO:0043872 is_a: CCO:F0002749 ! solute:solute antiporter activity [Term] id: CCO:F0006035 name: pyruvate-flavodoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin." [PMID:6352705, UniProt:Q3M8N0] subset: gosubset_prok synonym: "NifJ" RELATED [] synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT [] xref: EC:1.2.7.- xref: GO:0043873 xref: MetaCyc:PYFLAVOXRE-RXN is_a: CCO:F0003227 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0006036 name: acireductone synthase activity namespace: molecular_function def: "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77] comment: This function is involved in the process of methionine salvage. subset: gosubset_prok synonym: "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)" EXACT [EC:3.1.3.77] synonym: "E-1" RELATED [] synonym: "E-1 enolase-phosphatase" BROAD [] xref: EC:3.1.3.77 xref: GO:0043874 xref: MetaCyc:3.1.3.77-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0006037 name: 2-ketobutyrate formate-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN, PMID:9484901] comment: This function is part of an anaerobic pathway for the catabolism of L-threonine. subset: gosubset_prok synonym: "keto-acid formate acetyltransferase" BROAD [] synonym: "KFL" EXACT [] synonym: "TdcE" RELATED [] xref: EC:2.3.1- xref: GO:0043875 xref: MetaCyc:KETOBUTFORMLY-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006038 name: D-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde." [PMID:9642221, UniProt:A2SCK2] subset: gosubset_prok synonym: "D-allo-TA" EXACT [] synonym: "D-allo-threonine aldolase activity" EXACT [] synonym: "D-TA" EXACT [] synonym: "DtaAS" RELATED [] synonym: "low-specificity D-threonine aldolase" NARROW [] xref: EC:4.1.2.- xref: GO:0043876 is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006039 name: galactosamine-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3." [UniProt:P42912] comment: This function is part of the pathway of N-acetyl-galactosamine and galactosamine utilization. subset: gosubset_prok synonym: "AgaI" RELATED [] synonym: "galactosamine-6-phosphate deaminase activity" EXACT [] xref: EC:5.3.1.- xref: GO:0043877 is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0006040 name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+." [PMID:9497334] subset: gosubset_prok synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity" EXACT [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) activity" EXACT [] synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT [] xref: EC:1.2.1.- xref: GO:0043878 is_a: CCO:F0002279 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: CCO:F0006041 name: glycolate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)." [GOC:jl, http://en.wikipedia.org/, UniProt:Q46839] subset: gosubset_prok synonym: "glcA" RELATED [] synonym: "glycolate permease" RELATED [] synonym: "glycolic acid transmembrane transporter activity" EXACT [] synonym: "hydroxyacetic acid transmembrane transporter activity" EXACT [] xref: GO:0043879 is_a: CCO:F0001967 ! organic anion transmembrane transporter activity [Term] id: CCO:F0006042 name: crotonyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reduction of crotonyl-CoA to butyryl-CoA." [IPR:010085, PMID:11162231, UniProt:A1B8U5] subset: gosubset_prok synonym: "CCR" EXACT [] synonym: "crotonyl-coenzyme A reductase activity" EXACT [] xref: GO:0043880 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0006043 name: mesaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA." [PMID:16856935, PMID:16856937] comment: This function is part of an alternate glyoxylate cycle for acetate assimilation. subset: gosubset_prok synonym: "beta-methylmalyl-CoA dehydratase activity" EXACT [] synonym: "mch" RELATED [] synonym: "mesaconyl-coenzyme A hydratase activity" EXACT [] xref: GO:0043881 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006044 name: malate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)." [GOC:jl, UniProt:O05256] subset: gosubset_prok synonym: "malate Na(+) symporter" EXACT [] synonym: "malate-sodium symporter activity" EXACT [] synonym: "malate/sodium cotransporter activity" EXACT [] synonym: "malate/sodium symporter activity" EXACT [] synonym: "malate:Na+ symporter activity" EXACT [] synonym: "malate:sodium cotransporter activity" EXACT [] synonym: "Na(+)-malate symporter" EXACT [] synonym: "Na+:malate symporter activity" EXACT [] synonym: "sodium-dependent malate transporter" BROAD [] synonym: "sodium/malate symporter activity" EXACT [] synonym: "sodium:malate symporter activity" EXACT [] xref: GO:0043882 is_a: CCO:F0002745 ! anion:cation symporter activity [Term] id: CCO:F0006045 name: malolactic enzyme activity namespace: molecular_function def: "Catalysis of the reaction: malate + H+ = L-lactate + CO2." [MetaCyc:RXN8E-5623, PMID:3139053] comment: This function is part of the process of degradation of L-malic acid by lactic acid bacteria. subset: gosubset_prok synonym: "MleS" RELATED [] xref: EC:1.-.-.- xref: GO:0043883 xref: MetaCyc:RXN8E-5623 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0006046 name: CO-methylating acetyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA." [EC:2.3.1.169, PMID:1748656] subset: gosubset_prok synonym: "acetyl-CoA synthase activity" BROAD [] synonym: "acetyl-CoA:corrinoid protein O-acetyltransferase activity" EXACT [] synonym: "ACS" RELATED [EC:2.3.1.169] synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT [] xref: EC:2.3.1.169 xref: GO:0043884 xref: MetaCyc:ACETYLSYNCLTH-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006047 name: carbon-monoxide dehydrogenase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin." [EC:1.2.7.4] subset: gosubset_prok synonym: "carbon monoxide dehydrogenase (ferredoxin) activity" EXACT [] synonym: "carbon monoxide dehydrogenase activity" BROAD [] synonym: "carbon-monoxide dehydrogenase activity" BROAD [EC:1.2.7.4] synonym: "carbon-monoxide,water:ferredoxin oxidoreductase activity" EXACT [] synonym: "carbon-monoxide:(acceptor) oxidoreductase activity" EXACT [] synonym: "CO dehydrogenase activity" EXACT [] synonym: "CO-dehydrogenase (ferredoxin) activity" EXACT [] synonym: "CO-dehydrogenase activity" EXACT [] synonym: "CODH" RELATED [] xref: EC:1.2.7.4 xref: GO:0043885 xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN is_a: CCO:F0003227 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0006048 name: structural constituent of carboxysome namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide." [GOC:jl] subset: gosubset_prok xref: GO:0043886 is_a: CCO:F0001484 ! structural molecule activity [Term] id: CCO:F0006049 name: melibiose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)." [PMID:1970646, UniProt:P02921] subset: gosubset_prok synonym: "MelB" RELATED [] synonym: "melibiose carrier protein" RELATED [] synonym: "melibiose permease" BROAD [] synonym: "melibiose-Na+ symporter activity" EXACT [] synonym: "melibiose-sodium symporter activity" EXACT [] synonym: "melibiose/Na+ symporter activity" EXACT [] synonym: "melibiose/sodium symporter activity" EXACT [] synonym: "melibiose:Na+ symporter activity" EXACT [] synonym: "Na+ (Li+)/melibiose symporter" EXACT [] synonym: "Na+-melibiose symporter activity" EXACT [] synonym: "Na+/melibiose symporter activity" EXACT [] synonym: "Na+:melibiose symporter activity" EXACT [] synonym: "sodium-melibiose symporter activity" EXACT [] synonym: "sodium/melibiose symporter activity" EXACT [] synonym: "sodium:melibiose symporter activity" EXACT [] synonym: "thiomethylgalactoside permease II" RELATED [] xref: GO:0043887 is_a: CCO:F0002882 ! melibiose:monovalent cation symporter activity [Term] id: CCO:F0006052 name: N-acetylgalactosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate." [EC:3.1.6.4] subset: gosubset_prok synonym: "acetylgalactosamine 6-sulfatase activity" EXACT [] synonym: "chondroitin sulfatase" BROAD [] synonym: "chondroitinase" BROAD [] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.4] synonym: "galactose-6-sulfate sulfatase activity" EXACT [] synonym: "N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [] synonym: "N-acetylgalactosamine 6-sulfatase activity" EXACT [] synonym: "N-acetylgalactosamine-6-sulfate sulfatase activity" EXACT [] xref: EC:3.1.6.4 xref: GO:0043890 xref: MetaCyc:3.1.6.4-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0006053 name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." [EC:1.2.1.59] subset: gosubset_prok synonym: "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)" EXACT [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)" EXACT [] synonym: "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.59] synonym: "triosephosphate dehydrogenase (NAD(P))" EXACT [] synonym: "triosephosphate dehydrogenase (NAD(P)+)" EXACT [EC:1.2.1.59] xref: EC:1.2.1.59 xref: GO:0043891 xref: MetaCyc:GAPDHSYNEC-RXN is_a: CCO:F0002279 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: CCO:F0006054 name: methylglyoxal reductase (NADPH-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+." [EC:1.1.1.283] subset: gosubset_prok synonym: "Gre2" RELATED [] synonym: "lactaldehyde dehydrogenase (NADP+)" EXACT [] synonym: "lactaldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.283] xref: EC:1.1.1.283 xref: GO:0043892 xref: MetaCyc:1.1.1.283-RXN xref: MetaCyc:RXN-8636 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006055 name: acetate:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)." [GOC:jl] subset: gosubset_prok synonym: "acetate permease" BROAD [] synonym: "acetate-cation symporter activity" EXACT [] synonym: "acetate/cation symporter activity" EXACT [] synonym: "ActP" RELATED [] synonym: "cation-acetate symporter activity" EXACT [] synonym: "cation/acetate symporter activity" EXACT [] synonym: "cation:acetate symporter activity" EXACT [] xref: GO:0043893 is_a: CCO:F0002743 ! solute:cation symporter activity [Term] id: CCO:F0006056 name: protein acetyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate." [PMID:15236963] subset: gosubset_prok synonym: "Pat" RELATED [] synonym: "Pat enzyme" RELATED [] xref: GO:0043894 is_a: CCO:F0003130 ! acetyltransferase activity [Term] id: CCO:F0006057 name: cyclomaltodextrin glucanotransferase activity namespace: molecular_function def: "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond." [EC:2.4.1.19] synonym: "1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)" EXACT [] synonym: "alpha-1,4-glucan 4-glycosyltransferase, cyclizing" RELATED [] synonym: "alpha-cyclodextrin glucanotransferase" RELATED [] synonym: "alpha-cyclodextrin glycosyltransferase" RELATED [] synonym: "Bacillus macerans amylase" RELATED [] synonym: "beta-cyclodextrin glucanotransferase" RELATED [] synonym: "beta-cyclodextrin glycosyltransferase" RELATED [] synonym: "BMA" RELATED [] synonym: "CGTase" RELATED [] synonym: "cyclodextrin glucanotransferase" BROAD [] synonym: "cyclodextrin glycosyltransferase" RELATED [] synonym: "cyclomaltodextrin glucotransferase" RELATED [] synonym: "cyclomaltodextrin glycosyltransferase" RELATED [] synonym: "gamma-cyclodextrin glycosyltransferase" RELATED [] synonym: "konchizaimu" RELATED [] synonym: "neutral-cyclodextrin glycosyltransferase" RELATED [] xref: EC:2.4.1.19 xref: GO:0043895 xref: MetaCyc:2.4.1.19-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006058 name: glucan 1,6-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides." [EC:3.2.1.70] subset: gosubset_prok synonym: "exo-1,6-alpha-glucosidase activity" EXACT [EC:3.2.1.70] synonym: "exo-1,6-beta-glucosidase" RELATED [] synonym: "glucan alpha-1,6-D-glucohydrolase activity" EXACT [EC:3.2.1.70] synonym: "glucan-1,6-alpha-glucosidase activity" EXACT [] synonym: "glucodextranase activity" EXACT [EC:3.2.1.70] synonym: "glucodextrinase" BROAD [] xref: EC:3.2.1.70 xref: GO:0043896 xref: MetaCyc:3.2.1.70-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006059 name: glucan 1,4-alpha-maltohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains." [EC:3.2.1.133] subset: gosubset_prok synonym: "1,4-alpha-D-glucan alpha-maltohydrolase activity" EXACT [] synonym: "glucan-1,4-alpha-maltohydrolase activity" EXACT [] synonym: "maltogenic alpha-amylase activity" EXACT [] xref: EC:3.2.1.133 xref: GO:0043897 xref: MetaCyc:3.2.1.133-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006060 name: HDEL sequence binding namespace: molecular_function def: "Interacting selectively with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [PMID:1327759] synonym: "HDEL receptor activity" NARROW [] xref: GO:0045015 is_a: CCO:F0006275 ! ER retention sequence binding [Term] id: CCO:F0006061 name: peptidyl-glutamyl peptide hydrolyzing enzyme activity namespace: molecular_function def: "Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414] xref: GO:0045024 is_a: CCO:F0001783 ! peptidase activity [Term] id: CCO:F0006062 name: DNA end binding namespace: molecular_function def: "Interacting selectively with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs)." [GOC:jl] xref: GO:0045027 is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0006063 name: purinergic nucleotide receptor activity, G-protein coupled namespace: molecular_function def: "Combining with a purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:mah, PMID:9755289] synonym: "G protein coupled purinergic nucleotide receptor activity" EXACT [] synonym: "G-protein coupled purinergic nucleotide receptor activity" EXACT [] synonym: "G-protein-coupled purinergic nucleotide receptor activity" EXACT [] synonym: "P2Y" RELATED [] synonym: "purinergic nucleotide receptor activity, G protein coupled" EXACT [] xref: GO:0045028 is_a: CCO:F0000163 ! nucleotide receptor activity, G-protein coupled is_a: CCO:F0000165 ! purinergic nucleotide receptor activity [Term] id: CCO:F0006064 name: UDP-activated nucleotide receptor activity namespace: molecular_function xref: GO:0045029 is_a: CCO:F0002552 ! uridine nucleotide receptor activity [Term] id: CCO:F0006065 name: UTP-activated nucleotide receptor activity namespace: molecular_function xref: GO:0045030 is_a: CCO:F0002552 ! uridine nucleotide receptor activity [Term] id: CCO:F0006066 name: ATP-activated nucleotide receptor activity namespace: molecular_function xref: GO:0045031 is_a: CCO:F0000164 ! adenosine receptor activity, G-protein coupled [Term] id: CCO:F0006067 name: ADP-activated nucleotide receptor activity namespace: molecular_function xref: GO:0045032 is_a: CCO:F0000164 ! adenosine receptor activity, G-protein coupled [Term] id: CCO:F0006068 name: interleukin-18 alpha subunit binding namespace: molecular_function def: "Interacting selectively with the alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells." [PMID:10653850, UniProtKB:Q14116] synonym: "IL-18Ra binding" EXACT [] xref: GO:0045093 is_a: CCO:F0005596 ! interleukin-18 binding [Term] id: CCO:F0006069 name: interleukin-18 beta subunit binding namespace: molecular_function def: "Interacting selectively with the beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a." [PMID:10653850, UniProtKB:Q14116] synonym: "IL-18Rb binding" EXACT [] xref: GO:0045094 is_a: CCO:F0005596 ! interleukin-18 binding [Term] id: CCO:F0006070 name: azole transporter activity namespace: molecular_function def: "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of, within or between cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] xref: GO:0045118 is_a: CCO:F0002706 ! drug transporter activity [Term] id: CCO:F0006071 name: azole:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances." [GOC:ai, http://cancerweb.ncl.ac.uk/] synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW [] xref: GO:0045119 is_a: CCO:F0002753 ! drug:hydrogen antiporter activity [Term] id: CCO:F0006072 name: bioactive lipid receptor activity namespace: molecular_function xref: GO:0045125 is_a: CCO:F0001272 ! G-protein coupled receptor activity [Term] id: CCO:F0006073 name: N-acetylglucosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate." [EC:2.7.1.59] subset: gosubset_prok synonym: "2-acetylamino-2-deoxy-D-glucose kinase activity" EXACT [EC:2.7.1.59] synonym: "acetylaminodeoxyglucokinase activity" EXACT [EC:2.7.1.59] synonym: "acetylglucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.59] synonym: "ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.59] synonym: "ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.59] synonym: "GlcNAc kinase activity" EXACT [EC:2.7.1.59] xref: EC:2.7.1.59 xref: GO:0045127 xref: MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN is_a: CCO:F0004123 ! carbohydrate kinase activity [Term] id: CCO:F0006074 name: NAD-independent histone deacetylase activity namespace: molecular_function def: "Catalysis of the removal of acetyl groups from histones, independently of NAD." [GOC:ai] synonym: "AcuC" RELATED [] xref: GO:0045129 is_a: CCO:F0000816 ! histone deacetylase activity [Term] id: CCO:F0006075 name: keratan sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate." [EC:2.8.2.21] synonym: "3'-phosphoadenylyl keratan sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "3'-phosphoadenylylsulfate:keratan sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "keratan sulfate Gal-6-sulfotransferase activity" EXACT [] synonym: "keratan sulfate sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "keratan sulphotransferase activity" EXACT [] xref: EC:2.8.2.21 xref: GO:0045130 xref: MetaCyc:KERATAN-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0006076 name: pre-mRNA branch point binding namespace: molecular_function def: "Interacting selectively with a pre-mRNA branch point sequence, located upstream of the 3' splice site." [PMID:11691992, PMID:9722632] xref: GO:0045131 is_a: CCO:F0000313 ! mRNA binding is_a: CCO:F0004638 ! RNA splicing factor activity, transesterification mechanism [Term] id: CCO:F0006077 name: 2,3-dihydroxybenzoate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 3-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoate oxygenase activity" EXACT [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoic oxygenase activity" EXACT [EC:1.13.11.14] synonym: "o-pyrocatechuate oxygenase activity" EXACT [EC:1.13.11.14] xref: EC:1.13.11.14 xref: GO:0045133 xref: MetaCyc:1.13.11.14-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006078 name: uridine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6] synonym: "UDPase activity" EXACT [EC:3.6.1.6] synonym: "uridine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "uridine diphosphatase activity" EXACT [EC:3.6.1.6] xref: GO:0045134 is_a: CCO:F0003573 ! nucleoside-diphosphatase activity [Term] id: CCO:F0006079 name: poly(beta-D-mannuronate) lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [EC:4.2.2.3] subset: gosubset_prok synonym: "alginase activity" EXACT [EC:4.2.2.3] synonym: "alginase I" RELATED [EC:4.2.2.3] synonym: "alginate lyase activity" EXACT [EC:4.2.2.3] synonym: "alginate lyase I activity" NARROW [EC:4.2.2.3] synonym: "poly(beta-D-1,4-mannuronide) lyase activity" EXACT [EC:4.2.2.3] synonym: "poly(mana) alginate lyase activity" NARROW [EC:4.2.2.3] xref: EC:4.2.2.3 xref: GO:0045135 xref: MetaCyc:4.2.2.3-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006080 name: inositol phosphoceramide synthase activity namespace: molecular_function def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [MetaCyc:RXN3O-581, PMID:9405490, PMID:9614099] synonym: "IPC synthase activity" EXACT [] xref: EC:2.4.1.- xref: GO:0045140 xref: MetaCyc:RXN3O-581 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006081 name: triplex DNA binding namespace: molecular_function def: "Interacting selectively with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [PMID:10681538] xref: GO:0045142 is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0006082 name: single-stranded DNA specific 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai] xref: GO:0045145 is_a: CCO:F0001819 ! single-stranded DNA specific exodeoxyribonuclease activity is_a: CCO:F0005595 ! 5'-3' exodeoxyribonuclease activity [Term] id: CCO:F0006083 name: tripeptide aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of the N-terminal residue from a tripeptide." [EC:3.4.11.4] subset: gosubset_prok synonym: "alanine-phenylalanine-proline arylamidase activity" EXACT [EC:3.4.11.4] synonym: "aminoexotripeptidase activity" EXACT [EC:3.4.11.4] synonym: "aminotripeptidase activity" EXACT [] synonym: "imidoendopeptidase activity" EXACT [EC:3.4.11.4] synonym: "lymphopeptidase activity" EXACT [EC:3.4.11.4] synonym: "peptidase B" RELATED [EC:3.4.11.4] synonym: "peptidase T" EXACT [] synonym: "tripeptidase activity" EXACT [] xref: EC:3.4.11.4 xref: GO:0045148 xref: MetaCyc:3.4.11.4-RXN is_a: CCO:F0000646 ! aminopeptidase activity [Term] id: CCO:F0006084 name: antisigma factor binding namespace: molecular_function def: "Interacting selectively with an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator." [GOC:mlg] subset: gosubset_prok synonym: "antisigma factor antagonist activity" NARROW [] xref: GO:0045152 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006085 name: electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity namespace: molecular_function def: "Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] synonym: "cytochrome b562" NARROW [] synonym: "cytochrome b566" NARROW [] synonym: "cytochrome c1" NARROW [] synonym: "soluble cytochrome b562" RELATED [] xref: GO:0045153 xref: Reactome:19911 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0006086 name: electron transporter, transferring electrons within cytochrome c oxidase complex activity namespace: molecular_function def: "Enables the directed movement of electrons within the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] synonym: "cytochrome a" NARROW [] synonym: "cytochrome a3/copper complex" NARROW [] xref: GO:0045154 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0006087 name: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity namespace: molecular_function def: "Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363] subset: gosubset_prok synonym: "cytochrome" RELATED [] synonym: "cytochrome c" NARROW [] xref: GO:0045155 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0006088 name: electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity namespace: molecular_function def: "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] subset: gosubset_prok synonym: "cytochrome" RELATED [] synonym: "cytochrome bc1 complex" NARROW [] xref: GO:0045156 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0006089 name: electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity namespace: molecular_function def: "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] xref: GO:0045157 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0006090 name: electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity namespace: molecular_function def: "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] subset: gosubset_prok synonym: "cytochrome" RELATED [] synonym: "cytochrome b/b6" RELATED [] synonym: "cytochrome b6" NARROW [] synonym: "cytochrome f" NARROW [] xref: GO:0045158 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0006091 name: myosin II binding namespace: molecular_function def: "Interacting selectively with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] xref: GO:0045159 is_a: CCO:F0003516 ! myosin binding [Term] id: CCO:F0006092 name: glutathione dehydrogenase (ascorbate) activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate." [EC:1.8.5.1] synonym: "dehydroascorbate reductase activity" EXACT [] synonym: "dehydroascorbic acid reductase activity" EXACT [EC:1.8.5.1] synonym: "dehydroascorbic reductase activity" EXACT [EC:1.8.5.1] synonym: "DHA reductase activity" EXACT [EC:1.8.5.1] synonym: "GDOR" RELATED [EC:1.8.5.1] synonym: "glutathione dehydroascorbate reductase activity" EXACT [EC:1.8.5.1] synonym: "glutathione:dehydroascorbate oxidoreductase activity" EXACT [EC:1.8.5.1] synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" EXACT [EC:1.8.5.1] xref: EC:1.8.5.1 xref: GO:0045174 xref: MetaCyc:1.8.5.1-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0002535 ! glutathione disulfide oxidoreductase activity is_a: CCO:F0003069 ! antioxidant activity is_a: CCO:F0003265 ! oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor [Term] id: CCO:F0006093 name: glutamate synthase activity, NADH or NADPH as acceptor namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." [EC:1.4.1.13, EC:1.4.1.14] subset: gosubset_prok xref: EC:1.4.1.- xref: GO:0045181 is_a: CCO:F0003025 ! glutamate synthase activity is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006094 name: translation regulator activity namespace: molecular_function def: "Any substance involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: GO:0045182 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0006095 name: translation factor activity, non-nucleic acid binding namespace: molecular_function def: "Any of a group of soluble proteins involved in polypeptide synthesis at the ribosome which do not bind to nucleic acids." [GOC:ai] subset: gosubset_prok xref: GO:0045183 is_a: CCO:F0006094 ! translation regulator activity [Term] id: CCO:F0006096 name: natural killer cell receptor activity namespace: molecular_function def: "A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family." [GOC:ebc] synonym: "Ly49i" NARROW [] synonym: "NK cell receptor activity" EXACT [] xref: GO:0045233 is_a: CCO:F0001240 ! transmembrane receptor activity [Term] id: CCO:F0006097 name: CXCR chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892] synonym: "alpha chemokine receptor binding" EXACT [] synonym: "alpha chemokine receptor ligand" NARROW [] synonym: "C-X-C chemokine receptor ligand" NARROW [] synonym: "CXC chemokine receptor ligand" NARROW [] xref: GO:0045236 is_a: CCO:F0005665 ! chemokine receptor binding [Term] id: CCO:F0006098 name: CXCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with the CXCR1 chemokine receptor." [GOC:ceb, PMID:11910892] synonym: "CXCR1 chemokine receptor ligand" NARROW [] xref: GO:0045237 is_a: CCO:F0006097 ! CXCR chemokine receptor binding [Term] id: CCO:F0006099 name: CXCR2 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with the CXCR2 chemokine receptor." [GOC:ceb, PMID:11910892] synonym: "CXCR2 chemokine receptor ligand" NARROW [] xref: GO:0045238 is_a: CCO:F0006097 ! CXCR chemokine receptor binding [Term] id: CCO:F0006100 name: luciferin monooxygenase activity namespace: molecular_function def: "Catalysis of the oxidation of luciferin. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." [GOC:bf] synonym: "luciferase activity" EXACT [] synonym: "luciferase monooxygenase activity" RELATED [] xref: GO:0045289 is_a: CCO:F0000894 ! monooxygenase activity [Term] id: CCO:F0006101 name: D-arabinose 1-dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+. Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose." [EC:1.1.1.117] synonym: "D-arabinose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.117] xref: EC:1.1.1.117 xref: GO:0045290 xref: MetaCyc:1.1.1.117-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006102 name: alpha-catenin binding namespace: molecular_function def: "Interacting selectively with the alpha subunit of the catenin complex." [GOC:bf] xref: GO:0045294 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006103 name: gamma-catenin binding namespace: molecular_function def: "Interacting selectively with the gamma subunit of the catenin complex." [GOC:bf] xref: GO:0045295 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006104 name: cadherin binding namespace: molecular_function def: "Interacting selectively with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] xref: GO:0045296 is_a: CCO:F0008023 ! cell adhesion molecule binding [Term] id: CCO:F0006105 name: acyl-[acyl-carrier-protein] desaturase activity namespace: molecular_function def: "Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin." [EC:1.14.19.2] comment: Note that this function was formerly EC:1.14.99.6. subset: gosubset_prok synonym: "acyl-[acyl-carrier protein] desaturase activity" EXACT [] synonym: "acyl-acyl-carrier-protein desaturase activity" EXACT [EC:1.14.19.2] synonym: "acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.2] synonym: "stearyl acyl carrier protein desaturase activity" EXACT [EC:1.14.19.2] synonym: "stearyl-ACP desaturase activity" EXACT [EC:1.14.19.2] xref: EC:1.14.19.2 xref: GO:0045300 xref: MetaCyc:1.14.19.2-RXN xref: MetaCyc:PWY-5147 is_a: CCO:F0003300 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: CCO:F0006106 name: tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin." [GOC:mlg, PMID:8253666] subset: gosubset_prok synonym: "2-methylthio-cis-ribozeatin hydroxylase activity" EXACT [] synonym: "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity" EXACT [] synonym: "tRNA-(ms2io6A)-hydroxylase activity" EXACT [] xref: GO:0045301 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0006107 name: choloylglycine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine." [EC:3.5.1.24] subset: gosubset_prok synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity" EXACT [EC:3.5.1.24] synonym: "bile salt hydrolase activity" EXACT [EC:3.5.1.24] synonym: "choloyltaurine hydrolase activity" EXACT [EC:3.5.1.24] synonym: "glycocholase activity" EXACT [EC:3.5.1.24] xref: EC:3.5.1.24 xref: GO:0045302 xref: MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006108 name: diaminobutyrate-2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,4-diaminobutyrate + 2-oxoglutarate = L-glutamate + L-aspartic 4-semialdehyde." [EC:2.6.1.76] subset: gosubset_prok synonym: "2,4-diaminobutyrate 4-aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "DAB aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "DABA aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "diaminibutyric acid aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "diaminobutyrate transaminase activity" EXACT [EC:2.6.1.76] synonym: "diaminobutyrate--2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "EctB" RELATED [EC:2.6.1.76] synonym: "L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] xref: EC:2.6.1.76 xref: GO:0045303 xref: MetaCyc:2.6.1.76-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006109 name: protein phosphorylated amino acid binding namespace: molecular_function def: "Interacting selectively with a phosphorylated amino acid residue within a protein." [GOC:go_curators] synonym: "phosphoprotein amino acid binding" RELATED [] xref: GO:0045309 is_a: CCO:F0008071 ! phosphoprotein binding [Term] id: CCO:F0006110 name: unmethylated CpG binding namespace: molecular_function def: "Interacting selectively with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters." [GOC:ai, PMID:10688657] xref: GO:0045322 is_a: CCO:F0005877 ! sequence-specific DNA binding [Term] id: CCO:F0006111 name: aspartyl esterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue." [GOC:mah, UniProtKB:kwdictionary] subset: gosubset_prok xref: GO:0045330 is_a: CCO:F0003360 ! hydrolase activity, acting on ester bonds [Term] id: CCO:F0006112 name: mercury ion binding namespace: molecular_function def: "Interacting selectively with mercury (Hg) ions." [GOC:go_curators] subset: gosubset_prok synonym: "mercury binding" EXACT [] xref: GO:0045340 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0006113 name: interleukin-1 Type I receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to interleukin-1 Type I receptors." [GOC:ebc] synonym: "IL-1ra type I" EXACT [] xref: GO:0045352 is_a: CCO:F0001454 ! interleukin-1 receptor antagonist activity [Term] id: CCO:F0006114 name: interleukin-1 Type II receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to interleukin-1 Type II receptors." [GOC:ebc] synonym: "IL-1ra type II" EXACT [] xref: GO:0045353 is_a: CCO:F0001454 ! interleukin-1 receptor antagonist activity [Term] id: CCO:F0006115 name: chalcone isomerase activity namespace: molecular_function def: "Catalysis of the reaction: a chalcone = a flavanone." [EC:5.5.1.6] synonym: "chalcone--flavonone isomerase activity" EXACT [EC:5.5.1.6] synonym: "chalcone-flavanone isomerase activity" EXACT [] synonym: "flavanone lyase (decyclizing)" EXACT [EC:5.5.1.6] xref: EC:5.5.1.6 xref: GO:0045430 xref: MetaCyc:CHALCONE-ISOMERASE-RXN is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0006116 name: flavonol synthase activity namespace: molecular_function def: "Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O." [EC:1.14.11.23, ISBN:0943088372, PMID:7904213] synonym: "dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.23] synonym: "flavonoid 2-oxoglutarate-dependent dioxygenase activity" EXACT [EC:1.14.11.23] synonym: "FLS activity" RELATED [EC:1.14.11.23] xref: EC:1.14.11.23 xref: GO:0045431 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0006117 name: lycopene epsilon cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)." [PMID:8837512] synonym: "lycopene cyclase" BROAD [] xref: GO:0045435 is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0006118 name: lycopene beta cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively." [PMID:8837512] subset: gosubset_prok synonym: "crtL" RELATED [] synonym: "lycopene cyclase" BROAD [] xref: GO:0045436 xref: MetaCyc:RXN1F-150 is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0006119 name: uridine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: uridine + H2O = D-ribose + uracil." [EC:3.2.2.3] subset: gosubset_prok synonym: "uridine hydrolase activity" EXACT [] synonym: "uridine ribohydrolase activity" EXACT [EC:3.2.2.3] xref: EC:3.2.2.3 xref: GO:0045437 xref: MetaCyc:URIDINE-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0006120 name: L-cysteinyl-D-valine synthetase activity namespace: molecular_function def: "Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol." [PMID:1572368, PMID:2061333] synonym: "ACV synthetase activity" BROAD [] xref: GO:0045438 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0006121 name: isopenicillin-N epimerase activity namespace: molecular_function def: "Catalysis of the reaction: isopenicillin-N = penicillin-N." [EC:5.1.1.17, KEGG_PATHWAY:map00311] subset: gosubset_prok synonym: "isopenicillin N epimerase activity" EXACT [] synonym: "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity" EXACT [EC:5.1.1.17] xref: EC:5.1.1.17 xref: GO:0045439 xref: MetaCyc:5.1.1.17-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0006122 name: deacetoxycephalosporin C synthetase activity namespace: molecular_function def: "Catalysis of the formation of deacetoxycephalosporin from penicillin-N." [KEGG_PATHWAY:map00311] synonym: "DAOCS" EXACT [] synonym: "expandase activity" EXACT [] xref: GO:0045441 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0006123 name: deacetoxycephalosporin-C hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: deacetoxycephalosporin C + 2-oxoglutarate + O2 = deacetylcephalosporin C + succinate + CO2." [EC:1.14.11.26] synonym: "3'-methylcephem hydroxylase activity" EXACT [EC:1.14.11.26] synonym: "beta-lactam hydroxylase activity" EXACT [] synonym: "DACS" RELATED [EC:1.14.11.26] synonym: "DAOC hydroxylase activity" EXACT [EC:1.14.11.26] synonym: "deacetoxycephalosporin C hydroxylase activity" EXACT [EC:1.14.11.26] synonym: "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.26] synonym: "deacetylcephalosporin C synthase activity" EXACT [EC:1.14.11.26] xref: EC:1.14.11.26 xref: GO:0045442 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0006124 name: trichothecene 3-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis." [PMID:10583973] xref: GO:0045462 is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0006125 name: galactose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + H2O2." [EC:1.1.3.9] synonym: "beta-galactose oxidase activity" RELATED [EC:1.1.3.9] synonym: "D-galactose oxidase activity" EXACT [EC:1.1.3.9] synonym: "D-galactose:oxygen 6-oxidoreductase activity" EXACT [EC:1.1.3.9] xref: EC:1.1.3.9 xref: GO:0045480 xref: MetaCyc:GALACTOSE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0006126 name: 6-endo-hydroxycineole dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-endo-hydroxycineole + NAD+ = 6-oxocineole + NADH + H+." [EC:1.1.1.241] synonym: "6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.241] xref: EC:1.1.1.241 xref: GO:0045481 xref: MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006127 name: trichodiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = trichodiene + diphosphate." [EC:4.2.3.6] synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.6] synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)" EXACT [EC:4.2.3.6] synonym: "trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity" EXACT [EC:4.2.3.6] synonym: "trichodiene synthetase activity" EXACT [EC:4.2.3.6] xref: EC:4.2.3.6 xref: GO:0045482 xref: MetaCyc:TRICHODIENE-SYNTHASE-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0006128 name: aristolochene synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate." [EC:4.2.3.9] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9] synonym: "5-epi-aristolochene synthase activity" EXACT [EC:4.2.3.9] synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.9] synonym: "trans,trans-farnesyl diphosphate aristolochene-lyase activity" EXACT [EC:4.2.3.9] synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9] xref: EC:4.2.3.9 xref: GO:0045483 xref: MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0006129 name: L-lysine 6-transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + 2-oxoglutarate = 2-aminoadipate 6-semialdehyde + L-glutamate." [EC:2.6.1.36] subset: gosubset_prok synonym: "L-lysine aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine transaminase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine-alpha-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine:2-oxoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "lysine 6-aminotransferase activity" EXACT [] synonym: "lysine epsilon-aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "lysine epsilon-transaminase activity" EXACT [EC:2.6.1.36] synonym: "lysine:2-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] xref: EC:2.6.1.36 xref: GO:0045484 xref: MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006130 name: omega-6 fatty acid desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain." [PMID:7846158] xref: GO:0045485 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0006131 name: naringenin 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2." [EC:1.14.11.9] synonym: "(2S)-flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3-beta-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3-dioxygenase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3beta-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone synthase I activity" EXACT [EC:1.14.11.9] synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.9] synonym: "naringenin 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.9] xref: EC:1.14.11.9 xref: GO:0045486 xref: MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0006132 name: chemorepellent activity namespace: molecular_function def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "chemorepellant activity" EXACT [] xref: GO:0045499 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0006133 name: dynein binding namespace: molecular_function def: "Interacting selectively with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf] xref: GO:0045502 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006134 name: dynein light chain binding namespace: molecular_function def: "Interacting selectively with a light chain of the dynein complex." [GOC:bf] xref: GO:0045503 is_a: CCO:F0006133 ! dynein binding [Term] id: CCO:F0006135 name: dynein heavy chain binding namespace: molecular_function def: "Interacting selectively with a heavy chain of the dynein complex." [GOC:bf] xref: GO:0045504 is_a: CCO:F0006133 ! dynein binding [Term] id: CCO:F0006136 name: dynein intermediate chain binding namespace: molecular_function def: "Interacting selectively with an intermediate chain of the dynein complex." [GOC:bf] xref: GO:0045505 is_a: CCO:F0006133 ! dynein binding [Term] id: CCO:F0006137 name: interleukin-24 receptor activity namespace: molecular_function def: "Combining with interleukin-24 to initiate a change in cell activity." [GOC:jl] synonym: "IL-24R" EXACT [] xref: GO:0045506 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0006141 ! interleukin-24 binding [Term] id: CCO:F0006138 name: interleukin-25 receptor activity namespace: molecular_function def: "Combining with interleukin-25 to initiate a change in cell activity." [GOC:jl] synonym: "IL-25R" EXACT [] xref: GO:0045507 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0006142 ! interleukin-25 binding [Term] id: CCO:F0006139 name: interleukin-26 receptor activity namespace: molecular_function def: "Combining with interleukin-26 to initiate a change in cell activity." [GOC:jl] synonym: "IL-26R" EXACT [] xref: GO:0045508 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0006143 ! interleukin-26 binding [Term] id: CCO:F0006140 name: interleukin-27 receptor activity namespace: molecular_function def: "Combining with interleukin-27 to initiate a change in cell activity." [GOC:jl] synonym: "IL-27R" EXACT [] xref: GO:0045509 is_a: CCO:F0001254 ! interleukin receptor activity is_a: CCO:F0006144 ! interleukin-27 binding [Term] id: CCO:F0006141 name: interleukin-24 binding namespace: molecular_function def: "Interacting selectively with interleukin-24." [GOC:go_curators] synonym: "IL-24 binding" EXACT [] xref: GO:0045510 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0006142 name: interleukin-25 binding namespace: molecular_function def: "Interacting selectively with interleukin-25." [GOC:go_curators] synonym: "IL-25 binding" EXACT [] xref: GO:0045511 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0006143 name: interleukin-26 binding namespace: molecular_function def: "Interacting selectively with interleukin-26." [GOC:go_curators] synonym: "IL-26 binding" EXACT [] xref: GO:0045512 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0006144 name: interleukin-27 binding namespace: molecular_function def: "Interacting selectively with interleukin-27." [GOC:go_curators] synonym: "IL-27 binding" EXACT [] xref: GO:0045513 is_a: CCO:F0004230 ! interleukin binding [Term] id: CCO:F0006145 name: interleukin-16 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-16 receptor." [GOC:go_curators] synonym: "IL-16" NARROW [] synonym: "interleukin-16 receptor ligand" NARROW [] xref: GO:0045514 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006146 name: interleukin-18 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-18 receptor." [GOC:go_curators] synonym: "IL-18" NARROW [] synonym: "interleukin-18 receptor ligand" NARROW [] xref: GO:0045515 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006147 name: interleukin-19 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-19 receptor." [GOC:go_curators] synonym: "IL-19" NARROW [] synonym: "interleukin-19 receptor ligand" NARROW [] xref: GO:0045516 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006148 name: interleukin-20 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-20 receptor." [GOC:go_curators] synonym: "IL-20" NARROW [] synonym: "interleukin-20 receptor ligand" NARROW [] xref: GO:0045517 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006149 name: interleukin-22 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-22 receptor." [GOC:go_curators] synonym: "IL-22" NARROW [] synonym: "interleukin-22 receptor ligand" NARROW [] xref: GO:0045518 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006150 name: interleukin-23 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-23 receptor." [GOC:go_curators] synonym: "IL-23" NARROW [] synonym: "interleukin-23 receptor ligand" NARROW [] xref: GO:0045519 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006151 name: interleukin-24 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-24 receptor." [GOC:go_curators] synonym: "IL-24" NARROW [] synonym: "interleukin-24 receptor ligand" NARROW [] xref: GO:0045520 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006152 name: interleukin-25 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-25 receptor." [GOC:go_curators] synonym: "IL-25" NARROW [] synonym: "interleukin-25 receptor ligand" NARROW [] xref: GO:0045521 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006153 name: interleukin-26 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-26 receptor." [GOC:go_curators] synonym: "IL-26" NARROW [] synonym: "interleukin-26 receptor ligand" NARROW [] xref: GO:0045522 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006154 name: interleukin-27 receptor binding namespace: molecular_function def: "Interacting selectively with the interleukin-27 receptor." [GOC:go_curators] synonym: "IL-27" NARROW [] synonym: "interleukin-27 receptor ligand" NARROW [] xref: GO:0045523 is_a: CCO:F0001427 ! cytokine activity [Term] id: CCO:F0006155 name: gibberellin 2-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin 1 + 2-oxoglutarate + O2 = 2-beta-hydroxygibberellin 1 + succinate + CO2." [EC:1.14.11.13] synonym: "(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT [EC:1.14.11.13] synonym: "gibberellin 2-beta-hydroxylase activity" EXACT [EC:1.14.11.13] synonym: "gibberellin 2-oxidase activity" EXACT [] synonym: "gibberellin 2beta-dioxygenase activity" EXACT [EC:1.14.11.13] synonym: "gibberellin 2beta-hydroxylase activity" EXACT [EC:1.14.11.13] xref: EC:1.14.11.13 xref: GO:0045543 xref: MetaCyc:GIBBERELLIN-2-BETA-DIOXYGENASE-RXN xref: MetaCyc:PWY-102 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0006156 name: gibberellin 20-oxidase activity namespace: molecular_function def: "Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones." [PMID:7604047] xref: GO:0045544 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0006157 name: syndecan binding namespace: molecular_function def: "Interacting selectively with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] xref: GO:0045545 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006158 name: dehydrodolichyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [PMID:9858571] xref: GO:0045547 is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0006159 name: phenylalanine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3." [EC:4.3.1.5] synonym: "L-phenylalanine ammonia-lyase (trans-cinnamate-forming)" EXACT [EC:4.3.1.5] synonym: "L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.5] synonym: "L-tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.5] synonym: "PAL" RELATED [EC:4.3.1.5] synonym: "phenylalanine ammonium-lyase activity" EXACT [EC:4.3.1.5] synonym: "phenylalanine deaminase activity" EXACT [EC:4.3.1.5] synonym: "tyrase activity" EXACT [EC:4.3.1.5] synonym: "tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.5] xref: EC:4.3.1.5 xref: GO:0045548 xref: MetaCyc:PHENYLALANINE-AMMONIA-LYASE-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0006160 name: 9-cis-epoxycarotenoid dioxygenase activity namespace: molecular_function def: "Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal and 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al." [EC:1.13.11.51] synonym: "9-cis-epoxycarotenoid 11,12-dioxygenase activity" EXACT [EC:1.13.11.51] synonym: "AtNCED3" RELATED [EC:1.13.11.51] synonym: "NCED" RELATED [EC:1.13.11.51] synonym: "neoxanthin cleavage enzyme" BROAD [] synonym: "nine-cis-epoxycarotenoid dioxygenase activity" EXACT [EC:1.13.11.51] synonym: "PvNCED1" RELATED [EC:1.13.11.51] synonym: "VP14" RELATED [EC:1.13.11.51] xref: EC:1.13.11.51 xref: GO:0045549 is_a: CCO:F0002499 ! carotenoid dioxygenase activity [Term] id: CCO:F0006161 name: geranylgeranyl reductase activity namespace: molecular_function def: "Catalysis of the formation of phytyl moiety from the stepwise reduction of a geranylgeranyl moiety." [PMID:9492312] subset: gosubset_prok xref: GO:0045550 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0006162 name: cinnamyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+." [EC:1.1.1.195] synonym: "CAD activity" BROAD [EC:1.1.1.195] synonym: "cinnamyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.195] synonym: "cinnamyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.195] xref: EC:1.1.1.195 xref: GO:0045551 xref: MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006163 name: dihydrokaempferol 4-reductase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219] subset: gosubset_prok synonym: "cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.219] synonym: "dihydroflavanol 4-reductase activity" EXACT [EC:1.1.1.219] synonym: "dihydroflavonol 4-reductase activity" EXACT [EC:1.1.1.219] synonym: "dihydromyricetin reductase activity" EXACT [EC:1.1.1.219] synonym: "dihydroquercetin reductase activity" EXACT [EC:1.1.1.219] synonym: "NADPH-dihydromyricetin reductase activity" EXACT [EC:1.1.1.219] xref: EC:1.1.1.219 xref: GO:0045552 xref: MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006164 name: TRAIL binding namespace: molecular_function def: "Interacting selectively with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:go_curators, PMID:9082980] synonym: "Apo-2L binding" EXACT [] xref: GO:0045569 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006165 name: ketoreductase activity namespace: molecular_function def: "Catalysis of the reduction of a ketone group to form the corresponding alcohol." [EC:1.1.-.-] xref: EC:1.1.-.- xref: GO:0045703 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0006166 name: nutrient reservoir activity namespace: molecular_function def: "Functions in the storage of nutritious substrates." [GOC:ai] comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'. subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "storage protein" RELATED [] synonym: "storage protein of fat body (sensu Insecta)" RELATED [] synonym: "yolk protein" RELATED [] xref: GO:0045735 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0006167 name: precorrin-6Y C5,15-methyltransferase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2." [EC:2.1.1.132] subset: gosubset_prok synonym: "precorrin-6 methyltransferase activity" BROAD [EC:2.1.1.132] synonym: "precorrin-6Y methylase activity" BROAD [EC:2.1.1.132] synonym: "S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)" EXACT [EC:2.1.1.132] xref: EC:2.1.1.132 xref: GO:0046025 xref: MetaCyc:2.1.1.132-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0006168 name: precorrin-4 C11-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5." [EC:2.1.1.133] subset: gosubset_prok synonym: "CobM" RELATED [EC:2.1.1.133] synonym: "S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity" EXACT [EC:2.1.1.133] xref: EC:2.1.1.133 xref: GO:0046026 xref: MetaCyc:2.1.1.133-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0006169 name: phospholipid:diacylglycerol acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158] synonym: "PDAT activity" EXACT [EC:2.3.1.158] synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.158] xref: EC:2.3.1.158 xref: GO:0046027 xref: MetaCyc:2.3.1.158-RXN xref: Reactome:22783 is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0006170 name: electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity namespace: molecular_function def: "Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] synonym: "plastocyanin" NARROW [] xref: GO:0046028 is_a: CCO:F0002378 ! electron carrier activity [Term] id: CCO:F0006171 name: mannitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + NAD+ = D-mannose + NADH + H+." [EC:1.1.1.255] synonym: "mannitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.255] synonym: "MTD activity" EXACT [EC:1.1.1.255] synonym: "NAD-dependent mannitol dehydrogenase activity" BROAD [EC:1.1.1.255] xref: EC:1.1.1.255 xref: GO:0046029 xref: MetaCyc:1.1.1.255-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: CCO:F0004651 ! hexitol dehydrogenase activity [Term] id: CCO:F0006172 name: inositol trisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the removal of one of the three phosphate groups of an inositol trisphosphate." [GOC:bf] synonym: "inositol-1,4,5-trisphosphate phosphatase" NARROW [] xref: GO:0046030 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity [Term] id: CCO:F0006173 name: gluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-gluconate = ADP + 6-phospho-D-gluconate." [EC:2.7.1.12] subset: gosubset_prok synonym: "ATP:D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.12] synonym: "gluconate kinase activity" EXACT [EC:2.7.1.12] synonym: "gluconokinase (phosphorylating)" EXACT [EC:2.7.1.12] xref: EC:2.7.1.12 xref: GO:0046316 xref: MetaCyc:GLUCONOKIN-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006174 name: SMAD binding namespace: molecular_function def: "Interacting selectively with a SMAD signaling protein." [GOC:ai] xref: GO:0046332 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006175 name: aminoglycoside 3-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring." [GOC:cb] subset: gosubset_prok synonym: "3'-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81] synonym: "3-N-aminoglycoside acetyltransferase activity" EXACT [EC:2.3.1.81] synonym: "acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity" EXACT [EC:2.3.1.81] synonym: "acetyl-CoA:gentamicin-C N3'-acetyltransferase activity" NARROW [EC:2.3.1.60] synonym: "aminoglycoside acetyltransferase AAC(3)-1" RELATED [EC:2.3.1.60] synonym: "aminoglycoside acetyltransferase AAC(3)-I activity" RELATED [EC:2.3.1.60] synonym: "gentamicin 3'-N-acetyltransferase activity" NARROW [] synonym: "gentamicin acetyltransferase I activity" NARROW [EC:2.3.1.60] synonym: "gentamicin-(3)-N-acetyltransferase activity" NARROW [EC:2.3.1.81] synonym: "gentamycin 3'-N-acetyltransferase activity" EXACT [] synonym: "gentamycin acetyltransferase I" RELATED [EC:2.3.1.60] xref: EC:2.3.1.60 xref: EC:2.3.1.81 xref: GO:0016991 xref: GO:0046353 xref: MetaCyc:AMINOGLYCOSIDE-N3 xref: MetaCyc:GENTAMICIN-3 is_a: CCO:F0005513 ! aminoglycoside N-acetyltransferase activity [Term] id: CCO:F0006176 name: polynucleotide 3'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage." [EC:3.1.3.32] comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. synonym: "2'(3')-polynucleotidase activity" EXACT [EC:3.1.3.32] synonym: "5'-polynucleotidekinase 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "deoxyribonucleate 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "DNA 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "polynucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.32] xref: EC:3.1.3.32 xref: GO:0046403 xref: MetaCyc:POLYNUCLEOTIDE-3 is_a: CCO:F0004127 ! nucleotide phosphatase activity [Term] id: CCO:F0006177 name: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA." [EC:2.7.1.78] synonym: "ATP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP-dependent DNA kinase activity" EXACT [] synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] xref: EC:2.7.1.78 xref: GO:0046404 xref: MetaCyc:POLYNUCLEOTIDE-5 is_a: CCO:F0008169 ! polydeoxyribonucleotide kinase activity is_a: CCO:F0008170 ! ATP-dependent polynucleotide kinase activity [Term] id: CCO:F0006178 name: glycerol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O." [EC:4.2.1.30] subset: gosubset_prok synonym: "glycerol dehydrase activity" EXACT [EC:4.2.1.30] synonym: "glycerol hydro-lyase (3-hydroxypropanal-forming)" EXACT [EC:4.2.1.30] synonym: "glycerol hydro-lyase activity" EXACT [EC:4.2.1.30] xref: EC:4.2.1.30 xref: GO:0046405 xref: MetaCyc:GLYCEROL-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006179 name: magnesium protoporphyrin IX methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + magnesium protoporphyrin = S-adenosyl-L-homocysteine + magnesium protoporphyrin monomethyl ester." [EC:2.1.1.11] subset: gosubset_prok synonym: "(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "magnesium-protoporphyrin O-methyltransferase activity" EXACT [] synonym: "Mg-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] xref: EC:2.1.1.11 xref: GO:0046406 xref: MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN is_a: CCO:F0001758 ! O-methyltransferase activity is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0006180 name: chlorophyll synthetase activity namespace: molecular_function def: "Catalysis of the esterification reaction: chlorophyllide a + phytyl pyrophosphate = chlorophyll a + pyrophosphate." [ISBN:0471331309 "Biochemical Pathways", PMID:8552034] xref: GO:0046408 is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0006181 name: p-coumarate 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the 3-hydroxylation reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H20 + NADP+." [PMID:11429408, PMID:11891223] synonym: "cytochrome P450 CYP98A3" NARROW [] xref: GO:0046409 is_a: CCO:F0000894 ! monooxygenase activity [Term] id: CCO:F0006182 name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2." [EC:2.5.1.64, PMID:1459959] subset: gosubset_prok synonym: "2-oxoglutarate decarboxylase/SHCHC synthase activity" EXACT [EC:2.5.1.64] synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase--alpha-ketoglutarate decarboxylase activity" EXACT [EC:2.5.1.64] synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity" EXACT [EC:2.5.1.64] synonym: "6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity" EXACT [EC:2.5.1.64] synonym: "isochorismate:2-oxoglutarate:cyclodienyltransferase (decarboxylating, pyruvate-forming)" EXACT [EC:2.5.1.64] synonym: "SHCHC synthase activity" EXACT [EC:2.5.1.64] xref: EC:2.5.1.64 xref: GO:0046410 is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0006183 name: methylisocitrate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate." [EC:4.1.3.30] subset: gosubset_prok synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)" EXACT [EC:4.1.3.30] synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity" EXACT [EC:4.1.3.30] synonym: "2-methylisocitrate lyase activity" EXACT [] synonym: "MICL" RELATED [EC:4.1.3.30] xref: EC:4.1.3.30 xref: GO:0046421 xref: MetaCyc:METHYLISOCITRATE-LYASE-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0006184 name: violaxanthin de-epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; also antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O." [EC:1.10.99.3, GOC:ai, ISBN:0471331309 "Biochemical Pathways"] synonym: "VDE" RELATED [EC:1.10.99.3] synonym: "violaxanthin:ascorbate oxidoreductase activity" EXACT [EC:1.10.99.3] xref: EC:1.10.99.3 xref: GO:0046422 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0006185 name: allene-oxide cyclase activity namespace: molecular_function def: "Catalysis of the reaction: (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate." [EC:5.3.99.6] synonym: "(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)" EXACT [EC:5.3.99.6] xref: EC:5.3.99.6 xref: GO:0046423 xref: MetaCyc:ALLENE-OXIDE-CYCLASE-RXN is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0006186 name: ferulate 5-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+." [PMID:8692910, PMID:9880351] xref: GO:0046424 is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0006187 name: 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + pyrophosphate + CO2." [MetaCyc:DMK-RXN] synonym: "1,4-Dihydroxy-2-naphtoate prenyltransferase activity" EXACT [] xref: EC:2.5.1.- xref: GO:0046428 xref: MetaCyc:DMK-RXN is_a: CCO:F0000268 ! polyprenyltransferase activity [Term] id: CCO:F0006188 name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative way of naming 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.4.3, PMID:11752431] subset: gosubset_prok synonym: "(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating)" EXACT [EC:1.17.4.3] synonym: "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity" EXACT [] synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" EXACT [EC:1.17.4.3] xref: EC:1.17.4.3 xref: GO:0046429 is_a: CCO:F0003310 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [Term] id: CCO:F0006189 name: galactolipid galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol." [EC:2.4.1.184] synonym: "3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.184] synonym: "DGDG synthase activity" BROAD [EC:2.4.1.184] synonym: "digalactosyldiacylglycerol synthase activity" BROAD [EC:2.4.1.184] synonym: "galactolipid-galactolipid galactosyltransferase activity" EXACT [EC:2.4.1.184] synonym: "galactolipid:galactolipid galactosyltransferase activity" EXACT [] synonym: "GGGT activity" EXACT [EC:2.4.1.184] synonym: "interlipid galactosyltransferase activity" RELATED [EC:2.4.1.184] xref: EC:2.4.1.184 xref: GO:0046480 xref: MetaCyc:RXN-1226 is_a: CCO:F0001853 ! galactosyltransferase activity [Term] id: CCO:F0006190 name: digalactosyldiacylglycerol synthase namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol = UDP + 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol." [EC:2.4.1.241, MetaCyc:RXN-1225] synonym: "DGD1" NARROW [] synonym: "DGD2" NARROW [] synonym: "DGDG synthase activity" BROAD [EC:2.4.1.241] synonym: "UDP-galactose-dependent DGDG synthase activity" EXACT [EC:2.4.1.241] synonym: "UDP-galactose-dependent digalactosyldiacylglycerol synthase activity" EXACT [EC:2.4.1.241] synonym: "UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.241] synonym: "UDP-galactose:MGDG galactosyltransferase activity" EXACT [] xref: EC:2.4.1.241 xref: GO:0046481 xref: MetaCyc:RXN-1225 is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006191 name: UDPsulfoquinovose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + SO3(2-) (sulfite) = UDP-6-sulfoquinovose + H2O." [EC:3.13.1.1] synonym: "sulfite:UDP-glucose sulfotransferase activity" EXACT [] synonym: "UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity" EXACT [EC:3.13.1.1] synonym: "UDP-sulfoquinovose synthase activity" EXACT [EC:3.13.1.1] synonym: "UDPsulphoquinovose synthase activity" EXACT [] xref: EC:3.13.1.1 xref: GO:0046507 xref: MetaCyc:RXN-1223 is_a: CCO:F0006192 ! hydrolase activity, acting on carbon-sulfur bonds [Term] id: CCO:F0006192 name: hydrolase activity, acting on carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl] subset: gosubset_prok synonym: "hydrolase activity, acting on carbon-sulphur bonds" EXACT [] xref: EC:3.13 xref: GO:0046508 is_a: CCO:F0003359 ! hydrolase activity [Term] id: CCO:F0006193 name: 1,2-diacylglycerol 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + 1,2-diacylglycerol = UDP + 3-beta-D-galactosyl-1,2-diacylglycerol." [EC:2.4.1.46] synonym: "1-beta-MGDG activity" EXACT [EC:2.4.1.46] synonym: "1beta-MGDG" RELATED [EC:2.4.1.46] synonym: "MGDG synthase activity" EXACT [] synonym: "monogalactosyldiacylglycerol synthase activity" EXACT [] synonym: "UDP galactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] synonym: "UDP-galactose-diacylglyceride galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46] synonym: "UDP-galactose:diacylglycerol galactosyltransferase activity" EXACT [] synonym: "UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46] synonym: "uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] xref: EC:2.4.1.46 xref: GO:0046509 xref: MetaCyc:2.4.1.46-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006194 name: UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP." [MetaCyc:RXN-1224] synonym: "sulfolipid synthase" BROAD [] synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT [] xref: GO:0046510 xref: MetaCyc:RXN-1224 is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006195 name: S-methyl-5-thioribose kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + S5-methyl-5-thio-D-ribose = ADP + S5-methyl-5-thio-D-ribose 1-phosphate." [EC:2.7.1.100] subset: gosubset_prok synonym: "5-methylthioribose kinase (phosphorylating)" EXACT [EC:2.7.1.100] synonym: "5-methylthioribose kinase activity" EXACT [] synonym: "ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100] synonym: "ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100] synonym: "methylthioribose kinase activity" EXACT [EC:2.7.1.100] synonym: "MTR kinase activity" EXACT [EC:2.7.1.100] xref: EC:2.7.1.100 xref: GO:0046522 xref: MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006196 name: S-methyl-5-thioribose-1-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylthio-5-deoxy-D-ribose 1-phosphate = 5-methylthio-5-deoxy-D-ribulose 1-phosphate." [EC:5.3.1.23] subset: gosubset_prok synonym: "1-phospho-5'-S-methylthioribose isomerase activity" EXACT [EC:5.3.1.23] synonym: "1-PMTR isomerase activity" EXACT [EC:5.3.1.23] synonym: "5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23] synonym: "5-methylthioribose-1-phosphate isomerase activity" EXACT [] synonym: "methylthioribose 1-phosphate isomerase activity" EXACT [EC:5.3.1.23] synonym: "MTR-1-P isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] xref: EC:5.3.1.23 xref: GO:0046523 xref: MetaCyc:5.3.1.23-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0006197 name: sucrose-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate." [EC:2.4.1.14] subset: gosubset_prok synonym: "SPS" RELATED [EC:2.4.1.14] synonym: "sucrose 6-phosphate synthase activity" EXACT [EC:2.4.1.14] synonym: "sucrose phosphate synthetase activity" EXACT [EC:2.4.1.14] synonym: "sucrose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "sucrosephosphate-UDP glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDP-glucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDPglucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "uridine diphosphoglucose-fructose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] xref: EC:2.4.1.14 xref: GO:0046524 xref: MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006198 name: xylosylprotein 4-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.133] synonym: "galactosyltransferase I activity" RELATED [EC:2.4.1.133] synonym: "UDP-D-galactose:D-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "UDP-D-galactose:xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "UDP-galactose:xylose galactosyltransferase activity" EXACT [] synonym: "UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "uridine diphosphogalactose-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] xref: EC:2.4.1.133 xref: GO:0046525 xref: MetaCyc:2.4.1.133-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006199 name: D-xylulose reductase activity namespace: molecular_function def: "Catalysis of the reaction: xylitol + NAD+ = D-xylulose + NADH + H+." [EC:1.1.1.9] subset: gosubset_prok synonym: "xylitol dehydrogenase activity" EXACT [EC:1.1.1.9] xref: EC:1.1.1.9 xref: GO:0046526 xref: MetaCyc:D-XYLULOSE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: CCO:F0004651 ! hexitol dehydrogenase activity [Term] id: CCO:F0006200 name: glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.4.1.- xref: GO:0046527 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006201 name: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate without requiring the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] subset: gosubset_prok synonym: "PGAM-i" RELATED [EC:5.4.2.1] xref: GO:0046537 is_a: CCO:F0000998 ! phosphoglycerate mutase activity [Term] id: CCO:F0006202 name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; requires the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] subset: gosubset_prok synonym: "glycerate phosphomutase (diphosphoglycerate cofactor) activity" EXACT [EC:5.4.2.1] synonym: "PGAM-d" RELATED [EC:5.4.2.1] xref: GO:0046538 is_a: CCO:F0000998 ! phosphoglycerate mutase activity [Term] id: CCO:F0006203 name: histamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Nt-methylhistamine." [EC:2.1.1.8] synonym: "histamine 1-methyltransferase activity" EXACT [EC:2.1.1.8] synonym: "histamine methyltransferase activity" EXACT [EC:2.1.1.8] synonym: "histamine-methylating enzyme" RELATED [EC:2.1.1.8] synonym: "imidazolemethyltransferase activity" EXACT [EC:2.1.1.8] synonym: "S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity" EXACT [EC:2.1.1.8] synonym: "S-adenosylmethionine-histamine N-methyltransferase activity" EXACT [EC:2.1.1.8] xref: EC:2.1.1.8 xref: GO:0046539 xref: MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN is_a: CCO:F0001757 ! N-methyltransferase activity [Term] id: CCO:F0006204 name: trans-aconitate 3-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate." [EC:2.1.1.145] synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity" EXACT [EC:2.1.1.145] xref: EC:2.1.1.145 xref: GO:0046547 xref: MetaCyc:2.1.1.145-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0006205 name: D-malate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.83] synonym: "(R)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.83] synonym: "bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)" RELATED [EC:1.1.1.83] synonym: "D-malate dehydrogenase activity" EXACT [EC:1.1.1.83] synonym: "D-malic enzyme" RELATED [EC:1.1.1.83] xref: EC:1.1.1.83 xref: GO:0046553 xref: MetaCyc:1.1.1.83-RXN is_a: CCO:F0003217 ! malate dehydrogenase activity is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006206 name: malate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [EC:1.1.1.82] subset: gosubset_prok synonym: "(S)-malate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.82] synonym: "malate NADP dehydrogenase activity" EXACT [EC:1.1.1.82] synonym: "malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.82] synonym: "NADP malate dehydrogenase activity" EXACT [EC:1.1.1.82] synonym: "NADP-linked malate dehydrogenase activity" EXACT [EC:1.1.1.82] synonym: "NADP-malate dehydrogenase activity" EXACT [EC:1.1.1.82] xref: EC:1.1.1.82 xref: GO:0046554 xref: MetaCyc:MALATE-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003217 ! malate dehydrogenase activity is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006207 name: acetylxylan esterase activity namespace: molecular_function def: "Catalysis of the deacetylation of xylans and xylo-oligosaccharides." [EC:3.1.1.72] subset: gosubset_prok xref: EC:3.1.1.72 xref: GO:0046555 xref: MetaCyc:3.1.1.72-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006208 name: alpha-N-arabinofuranosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55] subset: gosubset_prok synonym: "alpha-arabinofuranosidase activity" EXACT [EC:3.2.1.55] synonym: "alpha-arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinanase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinofuranosidase activity" EXACT [] synonym: "alpha-L-arabinofuranoside arabinofuranohydrolase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinofuranoside hydrolase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "arabinofuranosidase activity" EXACT [EC:3.2.1.55] synonym: "arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "L-arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "polysaccharide alpha-L-arabinofuranosidase activity" EXACT [] xref: EC:3.2.1.55 xref: GO:0046556 xref: MetaCyc:3.2.1.55-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006209 name: glucan endo-1,6-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,6-linkages in 1,6-beta-D-glucans." [EC:3.2.1.75] synonym: "1,6-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucan hydrolase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucanase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucanase-pustulanase activity" EXACT [EC:3.2.1.75] synonym: "beta-1->6-glucan hydrolase activity" EXACT [EC:3.2.1.75] synonym: "endo-(1,6)-beta-D-glucanase activity" EXACT [] synonym: "endo-(1->6)-beta-D-glucanase activity" EXACT [EC:3.2.1.75] synonym: "endo-1,6-beta-D-glucanase activity" EXACT [EC:3.2.1.75] synonym: "endo-1,6-beta-glucanase activity" EXACT [EC:3.2.1.75] synonym: "endo-beta-1,6-glucanase activity" EXACT [EC:3.2.1.75] xref: EC:3.2.1.75 xref: GO:0046557 xref: MetaCyc:3.2.1.75-RXN is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0006210 name: arabinan endo-1,5-alpha-L-arabinosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,5-alpha-arabinofuranosidic linkages in 1,5-arabinans." [EC:3.2.1.99] subset: gosubset_prok synonym: "1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity" EXACT [EC:3.2.1.99] synonym: "endo-1,5-a-L-arabinanase activity" EXACT [] synonym: "endo-1,5-alpha-L-arabinanase activity" EXACT [EC:3.2.1.99] synonym: "endo-alpha-1,5-arabanase activity" EXACT [EC:3.2.1.99] synonym: "endo-arabanase activity" EXACT [EC:3.2.1.99] xref: EC:3.2.1.99 xref: GO:0046558 xref: MetaCyc:3.2.1.99-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006211 name: alpha-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.139] subset: gosubset_prok synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" EXACT [EC:3.2.1.139] synonym: "alpha-glucosiduronase activity" EXACT [EC:3.2.1.139] xref: EC:3.2.1.139 xref: GO:0046559 xref: MetaCyc:3.2.1.139-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006212 name: scytalidopepsin B activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." [EC:3.4.23.32] synonym: "Ganoderma lucidum aspartic proteinase activity" EXACT [EC:3.4.23.32] synonym: "Ganoderma lucidum carboxyl proteinase activity" EXACT [EC:3.4.23.32] synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32] synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32] synonym: "SLB" RELATED [EC:3.4.23.32] xref: EC:3.4.23.32 xref: GO:0046560 xref: MetaCyc:3.4.23.32-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0006213 name: penicillopepsin activity namespace: molecular_function def: "Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." [EC:3.4.23.20] synonym: "acid protease A" EXACT [] synonym: "Penicillium aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium caseicolum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium citrinum acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium citrinum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium cyclopium acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium duponti aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium expansum acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium expansum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium janthinellum acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium janthinellum aspartic protease activity" EXACT [EC:3.4.23.20] synonym: "Penicillium janthinellum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium roqueforti acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "peptidase A activity" BROAD [EC:3.4.23.20] xref: EC:3.4.23.20 xref: GO:0046561 xref: MetaCyc:3.4.23.20-RXN is_a: CCO:F0000659 ! aspartic-type endopeptidase activity [Term] id: CCO:F0006214 name: glucose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a hexose + O2 = a hexno-1,5-lactone + H2O2; includes beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.4, GOC:mah] synonym: "beta-D-glucose oxidase activity" EXACT [] synonym: "beta-D-glucose:oxygen 1-oxido-reductase activity" EXACT [EC:1.1.3.4] synonym: "beta-D-glucose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.4] synonym: "beta-D-glucose:quinone oxidoreductase activity" EXACT [EC:1.1.3.4] synonym: "corylophyline" RELATED [EC:1.1.3.4] synonym: "D-glucose oxidase activity" EXACT [EC:1.1.3.4] synonym: "D-glucose-1-oxidase activity" EXACT [EC:1.1.3.4] synonym: "deoxin-1" RELATED [EC:1.1.3.4] synonym: "glucose aerodehydrogenase activity" EXACT [EC:1.1.3.4] synonym: "glucose oxyhydrase activity" EXACT [EC:1.1.3.4] synonym: "GOD activity" RELATED [EC:1.1.3.4] synonym: "microcid" RELATED [EC:1.1.3.4] synonym: "penatin" RELATED [EC:1.1.3.4] xref: EC:1.1.3.4 xref: GO:0046562 xref: MetaCyc:GLUCOSE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0006215 name: methanol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde." [MetaCyc:METHANOL-OXIDASE-RXN] comment: Note that EC:1.1.3.31 was deleted from EC as it cannot be distinguished from alcohol oxidase (EC:1.1.3.13). xref: EC:1.1.3.- xref: GO:0046563 xref: MetaCyc:METHANOL-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0006216 name: oxalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: oxalate = formate + CO2." [EC:4.1.1.2] subset: gosubset_prok synonym: "oxalate carboxy-lyase (formate-forming)" EXACT [EC:4.1.1.2] synonym: "oxalate carboxy-lyase activity" EXACT [EC:4.1.1.2] xref: EC:4.1.1.2 xref: GO:0046564 xref: MetaCyc:OXALATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006217 name: 3-dehydroshikimate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate (protocatechuate) + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate." [EC:4.2.1.-, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN] xref: EC:4.2.1.- xref: GO:0046565 xref: MetaCyc:DHSHIKIMATE-DEHYDRO-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006218 name: DOPA dioxygenase activity namespace: molecular_function def: "Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid." [PMID:11711071] synonym: "dihydroxyphenylalanine dioxygenase activity" EXACT [] xref: GO:0046566 is_a: CCO:F0008070 ! dioxygenase activity [Term] id: CCO:F0006219 name: aphidicolan-16 beta-ol synthase activity namespace: molecular_function def: "Catalysis of the formation of aphidicolan-16 beta-ol from geranylgeranyl diphosphate." [PMID:12149019] xref: GO:0046567 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0006220 name: 3-methylbutanal reductase activity namespace: molecular_function def: "Catalysis of the reaction: isoamyl alcohol (3-methylbutanol) + NADP+ = isovaleraldehyde (3-methylbutanal) + NADPH + H+." [EC:1.1.1.265] synonym: "3-methylbutanol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.265] synonym: "3-methylbutyraldehyde reductase activity" EXACT [] synonym: "isoamyl alcohol oxidase activity" EXACT [] xref: EC:1.1.1.265 xref: GO:0046568 xref: MetaCyc:1.1.1.265-RXN is_a: CCO:F0000510 ! aldehyde reductase activity [Term] id: CCO:F0006221 name: glyoxal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2." [EC:1.2.3.-, PMID:11733005] synonym: "GLOX" EXACT [] xref: EC:1.2.3.- xref: GO:0046569 is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0006222 name: 5-methylthioribulose-1-phosphate 4-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: methylthioribulose-1-phosphate = 2,3-diketo-5-methylthio-1-phosphopentane + H2O." [MetaCyc:R145-RXN] xref: GO:0046570 xref: MetaCyc:R145-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006223 name: aspartate-2-keto-4-methylthiobutyrate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate." [MetaCyc:R15-RXN] xref: EC:2.6.1.- xref: GO:0046571 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006224 name: versicolorin B synthase activity namespace: molecular_function def: "Catalysis of the ring closure reaction: versiconal hemiacetal = versicolorin B + H2O." [PMID:8784203] xref: GO:0046572 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0006225 name: lactonohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group." [PMID:11640988] xref: GO:0046573 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006226 name: glycuronidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid." [PMID:10441389, PMID:12044176] synonym: "glucuronyl hydrolase activity" EXACT [] xref: GO:0046574 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006227 name: rhamnogalacturonan acetylesterase activity namespace: molecular_function def: "Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan." [PMID:10801485] xref: GO:0046575 is_a: CCO:F0001731 ! acetylesterase activity [Term] id: CCO:F0006228 name: rhamnogalacturonase B activity namespace: molecular_function def: "Catalysis of the cleavage of (1,2)-alpha-L-Rhap-(1,4)-alpha-D-GalpA glycosidic linkage, generating oligosaccharides terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue." [PMID:8587995, PMID:8720076] xref: GO:0046576 is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006229 name: long-chain-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O." [EC:1.1.3.20] synonym: "fatty alcohol oxidase activity" EXACT [] synonym: "fatty alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20] synonym: "long-chain fatty acid oxidase activity" EXACT [EC:1.1.3.20] synonym: "long-chain fatty alcohol oxidase activity" EXACT [] synonym: "long-chain-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20] xref: EC:1.1.3.20 xref: GO:0046577 xref: MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0006230 name: Rap GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rap family." [GOC:mah] xref: GO:0046582 is_a: CCO:F0001404 ! Ras GTPase activator activity [Term] id: CCO:F0006231 name: cation efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "cation efflux permease activity" EXACT [] xref: GO:0046583 is_a: CCO:F0001835 ! cation transmembrane transporter activity is_a: CCO:F0002942 ! efflux transmembrane transporter activity [Term] id: CCO:F0006232 name: ribonuclease T1 activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.3] subset: gosubset_prok synonym: "Aspergillus oryzae ribonuclease activity" NARROW [EC:3.1.27.3] synonym: "binase activity" EXACT [EC:3.1.27.3] synonym: "guanyl-specific RNase activity" EXACT [EC:3.1.27.3] synonym: "guanyloribonuclease activity" EXACT [EC:3.1.27.3] synonym: "ribonuclease C2" RELATED [EC:3.1.27.3] synonym: "ribonuclease Ch" RELATED [EC:3.1.27.3] synonym: "ribonuclease F1" EXACT [] synonym: "ribonuclease guaninenucleotido-2'-transferase (cyclizing)" EXACT [EC:3.1.27.3] synonym: "ribonuclease N1" RELATED [EC:3.1.27.3] synonym: "ribonuclease N3" RELATED [EC:3.1.27.3] synonym: "ribonuclease PP1" RELATED [EC:3.1.27.3] synonym: "ribonuclease SA" RELATED [EC:3.1.27.3] synonym: "ribonuclease U1" RELATED [EC:3.1.27.3] synonym: "RNase F1" RELATED [EC:3.1.27.3] synonym: "RNase G" RELATED [EC:3.1.27.3] synonym: "RNase N1 activity" EXACT [EC:3.1.27.3] synonym: "RNase N2 activity" EXACT [EC:3.1.27.3] synonym: "RNase Sa" RELATED [EC:3.1.27.3] synonym: "RNase T1" RELATED [EC:3.1.27.3] synonym: "RNase T1 activity" EXACT [] xref: EC:3.1.27.3 xref: GO:0046589 xref: MetaCyc:3.1.27.3-RXN is_a: CCO:F0000934 ! ribonuclease activity [Term] id: CCO:F0006233 name: polyamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N1-acetylspermine + O2 + H2O = N1-acetylspermidine + 3-aminopropanal + H2O2." [EC:1.5.3.11] synonym: "1-N-acetylspermidine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.5.3.11] synonym: "N1-acetylspermidine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.5.3.11] xref: EC:1.5.3.11 xref: GO:0046592 xref: MetaCyc:POLYAMINE-OXIDASE-RXN xref: Reactome:25469 is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0006234 name: mandelonitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde." [EC:4.1.2.10] synonym: "(R)-oxynitrilase activity" EXACT [EC:4.1.2.10] synonym: "D-alpha-hydroxynitrile lyase activity" EXACT [EC:4.1.2.10] synonym: "D-oxynitrilase activity" EXACT [EC:4.1.2.10] synonym: "hydroxynitrile lyase activity" BROAD [] synonym: "mandelonitrile benzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.10] synonym: "mandelonitrile benzaldehyde-lyase activity" EXACT [EC:4.1.2.10] xref: EC:4.1.2.10 xref: GO:0046593 xref: MetaCyc:MANDELONITRILE-LYASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006235 name: carotenoid isomerase activity namespace: molecular_function def: "Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids." [PMID:11884677] xref: GO:0046608 is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0006236 name: voltage-gated sulfate antiporter activity namespace: molecular_function synonym: "prestin" NARROW [] synonym: "voltage gated sulfate antiporter activity" EXACT [] synonym: "voltage-dependent sulfate antiporter activity" EXACT [] synonym: "voltage-sensitive sulfate antiporter activity" EXACT [] synonym: "voltage-sensitive sulphate antiporter activity" EXACT [] xref: GO:0046609 is_a: CCO:F0002746 ! antiporter activity [Term] id: CCO:F0006237 name: sphingolipid-translocating ATPase activity namespace: molecular_function def: "Catalysis of the movement of sphingolipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP." [GOC:ai, PMID:12034738] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "sphingolipid flippase activity" EXACT [] xref: GO:0046623 is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances is_a: CCO:F0006238 ! sphingolipid transporter activity [Term] id: CCO:F0006238 name: sphingolipid transporter activity namespace: molecular_function def: "Enables the directed movement of sphingolipids into, out of, within or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0046624 is_a: CCO:F0001556 ! lipid transporter activity [Term] id: CCO:F0006239 name: sphingolipid binding namespace: molecular_function def: "Interacting selectively with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0046625 is_a: CCO:F0001816 ! lipid binding [Term] id: CCO:F0006240 name: digestive hormone activity namespace: molecular_function def: "A hormone that takes part in the digestion process." [GOC:ai] synonym: "secretin (sensu Mammalia)" NARROW [] xref: GO:0046659 is_a: CCO:F0001479 ! hormone activity [Term] id: CCO:F0006241 name: galactoside 6-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside." [PMID:12413479] xref: GO:0046702 is_a: CCO:F0006273 ! alpha(1,6)-fucosyltransferase activity [Term] id: CCO:F0006242 name: natural killer cell lectin-like receptor binding namespace: molecular_function def: "Interacting selectively with a lectin-like natural killer cell receptor." [GOC:ai] synonym: "KLRC4 receptor binding" NARROW [] synonym: "NK cell lectin-like receptor binding" EXACT [] synonym: "NKG2D receptor binding" NARROW [] xref: GO:0046703 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0006243 name: boron binding namespace: molecular_function def: "Interacting selectively with boron, the group 13 element with properties which are borderline between metals and non-metals." [http://www.webelements.com/] subset: gosubset_prok xref: GO:0046714 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0006244 name: boron transporter activity namespace: molecular_function def: "Catalysis of the transport of boron across a membrane against the concentration gradient." [PMID:12447444] subset: gosubset_prok synonym: "efflux-type boron transporter" NARROW [] xref: GO:0046715 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0006245 name: host cell surface receptor binding namespace: molecular_function def: "Interacting selectively with a receptor on the host cell surface." [GOC:ai, PMID:11511370] subset: gosubset_prok synonym: "cell surface antigen activity, host-interacting" RELATED [] synonym: "cell surface receptor ligand" RELATED [] xref: GO:0046789 is_a: CCO:F0001407 ! receptor binding is_a: CCO:F0006249 ! host cell surface binding [Term] id: CCO:F0006246 name: virion binding namespace: molecular_function def: "Interacting selectively with a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai] xref: GO:0046790 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0006247 name: host cell extracellular matrix binding namespace: molecular_function def: "Interacting selectively with the extracellular matrix of a host cell." [PMID:7996163] subset: gosubset_prok xref: GO:0046810 is_a: CCO:F0008024 ! extracellular matrix binding [Term] id: CCO:F0006248 name: histone deacetylase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [GOC:ai, PMID:10482575] xref: GO:0046811 is_a: CCO:F0001213 ! enzyme inhibitor activity is_a: CCO:F0005557 ! histone deacetylase regulator activity [Term] id: CCO:F0006249 name: host cell surface binding namespace: molecular_function def: "Interacting selectively with the surface of a host cell." [GOC:ai] subset: goslim_pir subset: gosubset_prok xref: GO:0046812 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0006250 name: chemokine receptor antagonist activity namespace: molecular_function def: "Interacts with chemokine receptors to reduce the action of a chemokine." [GOC:ai, ISBN:0781718325] xref: GO:0046817 is_a: CCO:F0007301 ! receptor antagonist activity [Term] id: CCO:F0006251 name: 4-amino-4-deoxychorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate + glutamine = 4-amino-4-deoxychorismic acid + glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate." [GOC:krc, PMID:11495989, PMID:8346682] comment: Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. subset: gosubset_prok synonym: "ADC synthase activity" EXACT [EC:6.3.5.8] synonym: "aminodeoxychorismate synthase activity" RELATED [] synonym: "chorismate:L-glutamine amido-ligase activity" EXACT [EC:6.3.5.8] synonym: "p-aminobenzoate synthetase" RELATED [] synonym: "PabB activity" RELATED [EC:6.3.5.8] synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] synonym: "para-aminobenzoic acid synthase activity" RELATED [] xref: EC:6.3.5.8 xref: GO:0046820 xref: MetaCyc:PABASYN-RXN is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0006252 name: hydroxyapatite binding namespace: molecular_function def: "Interacting selectively with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentine." [http://cancerweb.ncl.ac.uk/] xref: GO:0046848 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0006253 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.7.1 xref: GO:0046857 is_a: CCO:F0003256 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: CCO:F0006254 name: ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity namespace: molecular_function def: "Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate." [PMID:10430961, PMID:10965036, PMID:2404515] comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. synonym: "rubisco activase activity" EXACT [] synonym: "rubisco activator" EXACT [] xref: GO:0046863 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0006255 name: cadmium ion binding namespace: molecular_function def: "Interacting selectively with cadmium (Cd) ions." [GOC:ai] subset: gosubset_prok synonym: "cadmium binding" EXACT [] synonym: "copper/cadmium binding" BROAD [] xref: GO:0046870 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0006256 name: N-acetylgalactosamine binding namespace: molecular_function def: "Interacting selectively with N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine." [GOC:ai, http://cancerweb.ncl.ac.uk/] synonym: "N-acetylgalactosamine lectin" RELATED [] xref: GO:0046871 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0006257 name: metal ion binding namespace: molecular_function def: "Interacting selectively with any metal ion." [GOC:ai] subset: gosubset_prok synonym: "heavy metal binding" NARROW [] synonym: "metal binding" EXACT [] xref: GO:0046872 is_a: CCO:F0005806 ! ion binding [Term] id: CCO:F0006258 name: metal ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "heavy metal ion porter activity" NARROW [] synonym: "heavy metal ion transporter activity" NARROW [] synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "heavy metal-exporting ATPase activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] xref: GO:0046873 is_a: CCO:F0002557 ! ion transmembrane transporter activity [Term] id: CCO:F0006259 name: ephrin receptor binding namespace: molecular_function def: "Interacting selectively with an ephrin receptor." [GOC:ai] synonym: "Eph receptor binding" EXACT [] synonym: "ephrin" NARROW [] synonym: "GPI-linked ephrin" NARROW [] synonym: "transmembrane ephrin" NARROW [] xref: GO:0046875 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0006260 name: 3,4-didehydroretinal binding namespace: molecular_function def: "Interacting selectively with 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "blue-sensitive opsin" NARROW [] synonym: "green-sensitive opsin" NARROW [] synonym: "long-wave-sensitive opsin" NARROW [] synonym: "opsin" NARROW [] synonym: "red-sensitive opsin" NARROW [] synonym: "short-wave-sensitive opsin" NARROW [] synonym: "UV-sensitive opsin" NARROW [] synonym: "violet-sensitive opsin" NARROW [] xref: GO:0046876 is_a: CCO:F0001639 ! retinoid binding [Term] id: CCO:F0006261 name: nucleoside triphosphate adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10] synonym: "GTP:AMP phosphotransferase" NARROW [] synonym: "guanosine triphosphate-adenylate kinase" NARROW [] synonym: "isozyme 3 of adenylate kinase activity" EXACT [EC:2.7.4.10] synonym: "nucleoside triphosphate-adenosine monophosphate transphosphorylase activity" EXACT [] synonym: "nucleoside-triphosphate-adenylate kinase activity" EXACT [] synonym: "nucleoside-triphosphate:AMP phosphotransferase activity" EXACT [EC:2.7.4.10] xref: EC:2.7.4.10 xref: GO:0046899 xref: MetaCyc:2.7.4.10-RXN is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor is_a: CCO:F0004128 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: CCO:F0006262 name: calcium oxalate binding namespace: molecular_function def: "Interacting selectively with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok xref: GO:0046904 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0006263 name: phytoene synthase activity namespace: molecular_function def: "Catalysis of the reaction: prephytoene pyrophosphate = phytoene + pyrophosphate." [GOC:ai, PMID:12641468] comment: Note that this should not be confused with 'geranylgeranyl-diphosphate geranylgeranyltransferase activity ; GO:0016767', EC:2.5.1.32. This activity is the second part of the formation of phytoene from geranylgeranyl-diphosphate, the first stage of which is catalyzed by EC:2.5.1.32. xref: GO:0046905 is_a: CCO:F0000343 ! catalytic activity [Term] id: CCO:F0006264 name: tetrapyrrole binding namespace: molecular_function def: "Interacting selectively with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "porphyrin binding" NARROW [] xref: GO:0046906 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0006265 name: pectinesterase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any pectinesterase enzyme." [GOC:ai, PMID:10880981] comment: See also the molecular function term 'pectinesterase activity ; GO:0030599'. xref: GO:0046910 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0006266 name: metal chelating activity namespace: molecular_function def: "The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] subset: gosubset_prok synonym: "heavy metal chelation" NARROW [] synonym: "metal chelation" EXACT [] xref: GO:0046911 is_a: CCO:F0006257 ! metal ion binding [Term] id: CCO:F0006267 name: transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl] subset: gosubset_prok xref: EC:2.3.3 xref: GO:0046912 is_a: CCO:F0003321 ! transferase activity, transferring acyl groups [Term] id: CCO:F0006268 name: transition metal ion binding namespace: molecular_function def: "Interacting selectively with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0046914 is_a: CCO:F0005808 ! cation binding is_a: CCO:F0006257 ! metal ion binding [Term] id: CCO:F0006269 name: transition metal ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0046915 is_a: CCO:F0006258 ! metal ion transmembrane transporter activity [Term] id: CCO:F0006270 name: triphosphoribosyl-dephospho-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine." [EC:2.7.8.25] subset: gosubset_prok synonym: "2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity" EXACT [EC:2.7.8.25] synonym: "ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity" EXACT [EC:2.7.8.25] synonym: "ATP:dephospho-CoA 5-triphosphoribosyl transferase activity" EXACT [] synonym: "CitG activity" RELATED [EC:2.7.8.25] xref: EC:2.7.8.25 xref: GO:0046917 xref: MetaCyc:2.7.8.25-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006271 name: pyruvyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another." [GOC:ai] xref: GO:0046919 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0006272 name: alpha(1,3)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,3)-linkage." [GOC:ai] xref: EC:2.4.1.- xref: GO:0046920 is_a: CCO:F0001884 ! fucosyltransferase activity [Term] id: CCO:F0006273 name: alpha(1,6)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,6)-linkage." [GOC:ai] xref: EC:2.4.1.- xref: GO:0046921 is_a: CCO:F0001884 ! fucosyltransferase activity [Term] id: CCO:F0006274 name: peptide-O-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221] synonym: "GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.221] synonym: "GDP-fucose protein O-fucosyltransferase activity" EXACT [EC:2.4.1.221] synonym: "GDP-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221] synonym: "GDP-L-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221] xref: EC:2.4.1.221 xref: GO:0046922 xref: MetaCyc:2.4.1.221-RXN is_a: CCO:F0001884 ! fucosyltransferase activity [Term] id: CCO:F0006275 name: ER retention sequence binding namespace: molecular_function def: "Interacting selectively with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai] synonym: "endoplasmic reticulum retention sequence binding" EXACT [] xref: GO:0046923 is_a: CCO:F0001368 ! signal sequence binding [Term] id: CCO:F0006276 name: sodium-transporting ATP synthase activity, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) = ATP + H2O + Na+(in), by a rotational mechanism." [EC:3.6.3.15, TC:3.A.2.1.2] synonym: "sodium-translocating F-type ATPase activity" EXACT [] synonym: "sodium-transporting two-sector ATPase activity" EXACT [] xref: GO:0046932 is_a: CCO:F0002562 ! sodium ion transmembrane transporter activity [Term] id: CCO:F0006277 name: hydrogen ion transporting ATP synthase activity, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1] subset: gosubset_prok synonym: "H+-transporting ATP synthase activity" EXACT [EC:3.6.3.14] synonym: "hydrogen ion translocating F-type ATPase activity" EXACT [] synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT [] xref: GO:0046933 xref: Reactome:78757 is_a: CCO:F0002559 ! hydrogen ion transmembrane transporter activity [Term] id: CCO:F0006278 name: phosphatidylinositol-4,5-bisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate." [EC:2.7.1.153] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.153] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "type I phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.153] xref: EC:2.7.1.153 xref: GO:0046934 xref: MetaCyc:2.7.1.153-RXN xref: Reactome:78763 is_a: CCO:F0005553 ! phosphoinositide 3-kinase activity [Term] id: CCO:F0006279 name: 1-phosphatidylinositol-3-kinase regulator activity namespace: molecular_function def: "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai] comment: See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'. synonym: "phosphatidylinositol 3-kinase regulator activity" EXACT [] synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" NARROW [] xref: GO:0046935 is_a: CCO:F0005556 ! phosphoinositide 3-kinase regulator activity [Term] id: CCO:F0006280 name: deoxyadenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: deoxyadenosine + H2O = deoxyinosine + NH3." [EC:3.5.4.4, GOC:ai] synonym: "deoxyadenosine deaminase reaction" EXACT [] xref: GO:0046936 is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0006281 name: azetidine-2-carboxylic acid acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid." [PMID:12761200] xref: EC:2.3.1.- xref: GO:0046941 is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0006282 name: carboxylic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] subset: gosubset_prok xref: GO:0046943 is_a: CCO:F0001570 ! organic acid transmembrane transporter activity [Term] id: CCO:F0006283 name: hydrogen ion transporting ATPase activity, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. subset: gosubset_prok synonym: "ATP phosphohydrolase (H+-transporting) activity" EXACT [EC:3.6.3.14] synonym: "ATP synthase activity" BROAD [EC:3.6.3.14] synonym: "bacterial Ca2+/Mg2+ ATPase" NARROW [EC:3.6.3.14] synonym: "chloroplast ATPase activity" NARROW [EC:3.6.3.14] synonym: "coupling factors (Fo, F1 and CF1)" RELATED [EC:3.6.3.14] synonym: "F(0)F(1)-ATPase activity" NARROW [EC:3.6.3.14] synonym: "F(1)-ATPase activity" NARROW [EC:3.6.3.14] synonym: "F(o)F(1)-ATPase activity" NARROW [EC:3.6.3.14] synonym: "F0F1-ATPase" NARROW [EC:3.6.3.14] synonym: "F1-ATPase" NARROW [EC:3.6.3.14] synonym: "FoF1-ATPase" NARROW [EC:3.6.3.14] synonym: "H(+)-transporting ATP synthase activity" EXACT [EC:3.6.3.14] synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.14] synonym: "H+-transporting ATPase activity" EXACT [EC:3.6.3.14] synonym: "H+-transporting two-sector ATPase" NARROW [EC:3.6.3.14] synonym: "hydrogen ion translocating A-type ATPase activity" NARROW [] synonym: "hydrogen ion translocating F-type ATPase activity" NARROW [] synonym: "hydrogen ion translocating V-type ATPase activity" NARROW [] synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW [] synonym: "mitochondrial ATPase activity" NARROW [EC:3.6.3.14] synonym: "proton-transporting ATPase activity, rotational mechanism" EXACT [] xref: GO:0046961 is_a: CCO:F0002559 ! hydrogen ion transmembrane transporter activity is_a: CCO:F0004186 ! cation-transporting ATPase activity [Term] id: CCO:F0006284 name: sodium-transporting ATPase activity, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out), by a rotational mechanism." [EC:3.6.3.15] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "ATP phosphohydrolase (Na+-transporting) activity" EXACT [EC:3.6.3.15] synonym: "ATP synthase, sodium ion specific activity" EXACT [EC:3.6.3.145] synonym: "Na(+)-translocating ATPase activity" BROAD [EC:3.6.3.15] synonym: "Na(+)-transporting two-sector ATPase activity" EXACT [EC:3.6.3.15] synonym: "Na+-translocating ATPase activity" EXACT [EC:3.6.3.15] synonym: "Na+-translocating F1Fo-ATPase" NARROW [EC:3.6.3.15] synonym: "Na+-transporting two-sector ATPase" NARROW [EC:3.6.3.15] synonym: "sodium transporting ATPase activity, rotational mechanism" EXACT [] synonym: "sodium-translocating F-type ATPase activity" NARROW [] synonym: "sodium-translocating V-type ATPase activity" NARROW [] synonym: "sodium-transporting two-sector ATPase activity" NARROW [] synonym: "vacuolar-type Na+-ATPase" NARROW [EC:3.6.3.15] synonym: "vacuolar-type Na+-translocating ATPase" NARROW [EC:3.6.3.15] xref: GO:0046962 is_a: CCO:F0002562 ! sodium ion transmembrane transporter activity is_a: CCO:F0004186 ! cation-transporting ATPase activity [Term] id: CCO:F0006285 name: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfatefrom one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "3'-phosphoadenosine 5'-phosphosulphate transporter activity" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity" EXACT [] synonym: "PAPS transporter activity" EXACT [] xref: GO:0046964 is_a: CCO:F0002682 ! purine nucleoside transmembrane transporter activity [Term] id: CCO:F0006286 name: retinoid X receptor binding namespace: molecular_function def: "Interacting selectively with a retinoid X receptor." [GOC:ai] synonym: "RXR binding" EXACT [] xref: GO:0046965 is_a: CCO:F0005774 ! retinoic acid receptor binding [Term] id: CCO:F0006287 name: thyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively with a thyroid hormone receptor." [GOC:ai] synonym: "ligand-dependent thyroid hormone receptor interactor activity" NARROW [] xref: GO:0046966 is_a: CCO:F0001738 ! transcription factor binding is_a: CCO:F0005585 ! nuclear hormone receptor binding [Term] id: CCO:F0006288 name: NAD-dependent histone deacetylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the NAD-dependent removal of an acetyl group from lysine at position 9 of the histone H3 protein." [GOC:ai] xref: GO:0046969 is_a: CCO:F0003591 ! NAD-dependent histone deacetylase activity is_a: CCO:F0004947 ! histone deacetylase activity (H3-K9 specific) [Term] id: CCO:F0006289 name: NAD-dependent histone deacetylase activity (H4-K16 specific) namespace: molecular_function def: "Catalysis of the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [GOC:ai] xref: GO:0046970 is_a: CCO:F0003591 ! NAD-dependent histone deacetylase activity [Term] id: CCO:F0006290 name: histone acetyltransferase activity (H4-K16 specific) namespace: molecular_function def: "Catalysis of the addition of an acetyl group onto lysine at position 16 of the histone H4 protein." [GOC:ai] synonym: "histone lysine acetyltransferase activity (H4-K16 specific)" EXACT [] xref: GO:0046972 is_a: CCO:F0000813 ! histone acetyltransferase activity [Term] id: CCO:F0006291 name: histone lysine N-methyltransferase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai] xref: GO:0046974 is_a: CCO:F0003617 ! histone-lysine N-methyltransferase activity [Term] id: CCO:F0006292 name: histone lysine N-methyltransferase activity (H3-K36 specific) namespace: molecular_function def: "Catalysis of the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [GOC:ai] xref: GO:0046975 is_a: CCO:F0003617 ! histone-lysine N-methyltransferase activity [Term] id: CCO:F0006293 name: histone lysine N-methyltransferase activity (H3-K27 specific) namespace: molecular_function def: "Catalysis of the addition of a methyl group onto lysine at position 27 of the histone H3 protein." [GOC:ai] xref: GO:0046976 is_a: CCO:F0003617 ! histone-lysine N-methyltransferase activity [Term] id: CCO:F0006294 name: TAP binding namespace: molecular_function def: "Interacting selectively with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2." [PMID:11133832] xref: GO:0046977 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006295 name: TAP1 binding namespace: molecular_function def: "Interacting selectively with the TAP1 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] xref: GO:0046978 is_a: CCO:F0006294 ! TAP binding [Term] id: CCO:F0006296 name: TAP2 binding namespace: molecular_function def: "Interacting selectively with the TAP2 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] xref: GO:0046979 is_a: CCO:F0006294 ! TAP binding [Term] id: CCO:F0006297 name: tapasin binding namespace: molecular_function def: "Interacting selectively with tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules." [PMID:12594855] xref: GO:0046980 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006298 name: beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." [GOC:bf, PMID:12130631, PMID:12130651] synonym: "UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [] xref: GO:0046981 is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006299 name: protein heterodimerization activity namespace: molecular_function def: "Interacting selectively with a nonidentical protein to form a heterodimer." [GOC:ai] xref: GO:0046982 is_a: CCO:F0006300 ! protein dimerization activity [Term] id: CCO:F0006300 name: protein dimerization activity namespace: molecular_function def: "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0046983 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006301 name: N-acetyllactosamine beta-1,3-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570] synonym: "galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity" EXACT [] xref: GO:0046987 is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0006302 name: asioloorosomucoid beta-1,3-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570] xref: GO:0046988 is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0006303 name: galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570] xref: GO:0046989 is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0006304 name: N-hydroxyarylamine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine." [EC:2.3.1.118, MetaCyc:2.3.1.118-RXN] subset: gosubset_prok synonym: "acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity" EXACT [EC:2.3.1.118] synonym: "arylhydroxamate N,O-acetyltransferase activity" EXACT [EC:2.3.1.118] synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" EXACT [EC:2.3.1.118] xref: EC:2.3.1.118 xref: GO:0046990 xref: MetaCyc:2.3.1.118-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0006305 name: hydroxynitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyronitrile = cyanide + acetone." [EC:4.1.2.39, MetaCyc:4.1.2.39-RXN] synonym: "(S)-acetone-cyanohydrin lyase activity" EXACT [EC:4.1.2.39] synonym: "2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)" EXACT [EC:4.1.2.39] synonym: "2-hydroxyisobutyronitrile acetone-lyase activity" EXACT [EC:4.1.2.39] synonym: "hydroxynitrile lyase activity" BROAD [] synonym: "oxynitrilase activity" BROAD [EC:4.1.2.39] xref: EC:4.1.2.39 xref: GO:0046991 xref: MetaCyc:4.1.2.39-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006306 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y." [GOC:ai] comment: Note that enzymes of class EC:1.21.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" NARROW [] xref: EC:1.21 xref: GO:0046992 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0006307 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen." [GOC:ai] subset: gosubset_prok xref: EC:1.21.3 xref: GO:0046993 is_a: CCO:F0006306 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond [Term] id: CCO:F0006308 name: oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound." [GOC:jl] subset: gosubset_prok xref: EC:1.12.5 xref: GO:0046994 is_a: CCO:F0003281 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: CCO:F0006309 name: oxidoreductase activity, acting on hydrogen as donor, with other known acceptors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound." [GOC:ai] subset: gosubset_prok xref: EC:1.12.98 xref: GO:0046995 is_a: CCO:F0003281 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: CCO:F0006310 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated." [GOC:mah] xref: EC:1.14.21 xref: GO:0046996 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0006311 name: oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl] subset: gosubset_prok xref: EC:1.5.8 xref: GO:0046997 is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0006313 name: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 2-dehydro-3-deoxy-D-gluconate = NADPH + H+ + (4S,5S)-4,5-dehydroxy-2,6-dioxohexanoate." [EC:1.1.1.126, MetaCyc:1.1.1.126-RXN] synonym: "2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.126] synonym: "2-keto-3-deoxy-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.126] xref: EC:1.1.1.126 xref: GO:0047000 xref: MetaCyc:1.1.1.126-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006314 name: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate." [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN] synonym: "2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxygluconate 5-dehydrogenase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.127] xref: EC:1.1.1.127 xref: GO:0047001 xref: MetaCyc:1.1.1.127-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006315 name: L-arabinitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + L-arabitol = NADH + H+ + L-ribulose." [EC:1.1.1.13, MetaCyc:1.1.1.13-RXN] synonym: "L-arabinitol 2-dehydrogenase (ribulose forming) activity" EXACT [] xref: EC:1.1.1.13 xref: GO:0047002 xref: MetaCyc:1.1.1.13-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006316 name: dTDP-6-deoxy-L-talose 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + dTDP-6-deoxy-L-talose = NADPH + dTDP-4-dehydro-6-deoxy-L-mannose." [EC:1.1.1.134, MetaCyc:1.1.1.134-RXN] synonym: "dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)" EXACT [EC:1.1.1.134] synonym: "dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.134] synonym: "TDP-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134] synonym: "thymidine diphospho-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134] xref: EC:1.1.1.134 xref: GO:0047003 xref: MetaCyc:1.1.1.134-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006317 name: UDP-N-acetylglucosamine 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 2 NAD+ + UDP-N-acetyl-D-glucosamine = 2 NADH + 2 H+ + UDP-N-acetyl-2-amino-d-glucuronate." [EC:1.1.1.136, MetaCyc:1.1.1.136-RXN] synonym: "UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.136] synonym: "UDP-GLcNAc dehydrogenase activity" EXACT [EC:1.1.1.136] synonym: "UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.136] synonym: "UDPacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136] synonym: "uridine diphosphoacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136] xref: EC:1.1.1.136 xref: GO:0047004 xref: MetaCyc:1.1.1.136-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006318 name: 16-alpha-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid." [EC:1.1.1.147, MetaCyc:1.1.1.147-RXN] synonym: "16alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.147] synonym: "16alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.147] synonym: "16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity" EXACT [EC:1.1.1.147] xref: EC:1.1.1.147 xref: GO:0047005 xref: MetaCyc:1.1.1.147-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006319 name: 20-alpha-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] subset: gosubset_prok synonym: "20alpha-HSD" RELATED [EC:1.1.1.149] synonym: "20alpha-HSDH" RELATED [EC:1.1.1.149] synonym: "20alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.149] synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149] synonym: "20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" EXACT [EC:1.1.1.149] xref: EC:1.1.1.149 xref: GO:0047006 xref: MetaCyc:1.1.1.149-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006320 name: 21-hydroxysteroid dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + pregnan-21-ol = NADH + H+ + pregnan-21-al." [EC:1.1.1.150, MetaCyc:1.1.1.150-RXN] synonym: "21-hydroxysteroid:NAD+ 21-oxidoreductase activity" EXACT [EC:1.1.1.150] xref: EC:1.1.1.150 xref: GO:0047007 xref: MetaCyc:1.1.1.150-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006321 name: 21-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + pregnan-21-ol = NADPH + H+ + pregnan-21-al." [EC:1.1.1.151, MetaCyc:1.1.1.151-RXN] synonym: "21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.151] synonym: "21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity" EXACT [EC:1.1.1.151] synonym: "21-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.151] synonym: "21-hydroxysteroid:NADP+ 21-oxidoreductase activity" EXACT [EC:1.1.1.151] synonym: "NADP-21-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.151] xref: EC:1.1.1.151 xref: GO:0047008 xref: MetaCyc:1.1.1.151-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006322 name: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione." [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN] synonym: "3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] synonym: "3alpha-hydroxy-5beta-steroid dehydrogenase activity" EXACT [EC:1.1.1.152] synonym: "3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.152] synonym: "etiocholanolone 3-alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] synonym: "etiocholanolone 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] xref: EC:1.1.1.152 xref: GO:0047009 xref: MetaCyc:1.1.1.152-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006323 name: hydroxycyclohexanecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate = NADH + H+ + (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate." [EC:1.1.1.166, MetaCyc:1.1.1.166-RXN] synonym: "(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity" EXACT [EC:1.1.1.166] synonym: "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.166] synonym: "dihydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.166] xref: EC:1.1.1.166 xref: GO:0047010 xref: MetaCyc:1.1.1.166-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006324 name: 2-dehydropantolactone reductase (A-specific) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN] synonym: "(R)-pantolactone:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.1.1.168] synonym: "2-dehydropantoyl-lactone reductase (A-specific) activity" EXACT [EC:1.1.1.168] synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.168] synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] xref: EC:1.1.1.168 xref: GO:0047011 xref: MetaCyc:1.1.1.168-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006325 name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one." [EC:1.1.1.170, MetaCyc:1.1.1.170-RXN] synonym: "3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" EXACT [] synonym: "3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [EC:1.1.1.170] synonym: "3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity" RELATED [EC:1.1.1.170] synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] synonym: "sterol 4-alpha-carboxylic decarboxylase activity" RELATED [EC:1.1.1.170] xref: EC:1.1.1.170 xref: GO:0047012 xref: MetaCyc:1.1.1.170-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006326 name: 12-alpha-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate = NADPH + H+ + 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate." [EC:1.1.1.176, MetaCyc:1.1.1.176-RXN] subset: gosubset_prok synonym: "12alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.176] synonym: "12alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.176] synonym: "12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity" EXACT [EC:1.1.1.176] synonym: "NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.176] synonym: "NADP-12alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.176] xref: EC:1.1.1.176 xref: GO:0047013 xref: MetaCyc:1.1.1.176-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006327 name: glycerol-3-phosphate 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + glycerol-3-phosphate = NADPH + H+ + glyceraldehyde-3-phosphate." [EC:1.1.1.177, MetaCyc:1.1.1.177-RXN] synonym: "glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177] synonym: "glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.177] synonym: "L-glycerol 3-phosphate:NADP oxidoreductase activity" EXACT [EC:1.1.1.177] synonym: "NADPH-dependent glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177] synonym: "sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.177] xref: EC:1.1.1.177 xref: GO:0047014 xref: MetaCyc:1.1.1.177-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006328 name: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA." [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN] synonym: "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.178] synonym: "2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity" EXACT [EC:1.1.1.178] synonym: "2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.178] synonym: "2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.178] xref: EC:1.1.1.178 xref: GO:0047015 xref: MetaCyc:1.1.1.178-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006329 name: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one." [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN] synonym: "3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity" EXACT [EC:1.1.1.181] synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.181] synonym: "cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity" EXACT [EC:1.1.1.181] synonym: "cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.181] xref: EC:1.1.1.181 xref: GO:0047016 xref: MetaCyc:1.1.1.181-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006330 name: prostaglandin-F synthase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN] synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity" EXACT [EC:1.1.1.188] synonym: "NADPH-dependent prostaglandin D2 11-keto reductase activity" EXACT [EC:1.1.1.188] synonym: "PGD(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "PGD2 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "PGF synthetase activity" EXACT [EC:1.1.1.188] synonym: "PGF2alpha synthetase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin 11-keto reductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin D2-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin F synthase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin F synthetase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D(2) 11-reductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D(2) ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D2 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D2 11-reductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D2 ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-F synthetase activity" EXACT [EC:1.1.1.188] synonym: "reductase, 15-hydroxy-11-oxoprostaglandin" EXACT [EC:1.1.1.188] synonym: "synthetase, prostaglandin F2alpha" EXACT [EC:1.1.1.188] xref: EC:1.1.1.188 xref: GO:0047017 xref: MetaCyc:1.1.1.188-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006331 name: indole-3-acetaldehyde reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + indole-3-ethanol = NADH + H+ + indole acetaldehyde." [EC:1.1.1.190, MetaCyc:1.1.1.190-RXN] synonym: "(indol-3-yl)ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190] synonym: "indole-3-ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190] synonym: "indoleacetaldehyde reductase activity" EXACT [EC:1.1.1.190] xref: EC:1.1.1.190 xref: GO:0047018 xref: MetaCyc:1.1.1.190-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006332 name: indole-3-acetaldehyde reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + indole-3-ethanol = NADPH + H+ + indole acetaldehyde." [EC:1.1.1.191, MetaCyc:1.1.1.191-RXN] synonym: "(indol-3-yl)ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191] synonym: "indole-3-ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191] synonym: "indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.191] xref: EC:1.1.1.191 xref: GO:0047019 xref: MetaCyc:1.1.1.191-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006333 name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate." [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN] synonym: "(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.196] synonym: "15-hydroxy PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "15-hydroxyprostaglandin dehydrogenase (NADP)" EXACT [EC:1.1.1.196] synonym: "dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.196] synonym: "dehydrogenase, prostaglandin D2" EXACT [EC:1.1.1.196] synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] synonym: "NADP-linked prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "NADP-PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] synonym: "prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "prostaglandin-D 15-dehydrogenase (NADP(+)) activity" EXACT [EC:1.1.1.196] synonym: "prostaglandin-D 15-dehydrogenase (NADP)" EXACT [EC:1.1.1.196] synonym: "prostaglandin-D 15-dehydrogenase (NADP+) activity" EXACT [EC:1.1.1.196] xref: EC:1.1.1.196 xref: GO:0047020 xref: MetaCyc:1.1.1.196-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006334 name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate = NADPH + H+ + (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate." [EC:1.1.1.197, MetaCyc:1.1.1.197-RXN] synonym: "(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.197] synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] synonym: "type II 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.197] xref: EC:1.1.1.197 xref: GO:0047021 xref: MetaCyc:1.1.1.197-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006335 name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 7-beta-hydroxysteroid = NADPH + H+ + 7-oxosteroid." [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN] synonym: "7beta-hydroxysteroid dehydrogenase (NADP+)" EXACT [EC:1.1.1.201] synonym: "7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.201] synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201] synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201] xref: EC:1.1.1.201 xref: GO:0047022 xref: MetaCyc:1.1.1.201-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006336 name: 3(or 17)-alpha-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione." [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN] synonym: "3(17)alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.209] synonym: "3(or 17)alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.209] synonym: "3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.209] xref: EC:1.1.1.209 xref: GO:0047023 xref: MetaCyc:1.1.1.209-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006337 name: 3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5-alpha-androstan-3-beta,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADPH + H+." [EC:1.1.1.210, MetaCyc:1.1.1.210-RXN] synonym: "3-beta-HSD activity" EXACT [EC:1.1.1.210] synonym: "3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.210] synonym: "3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.210] synonym: "3beta,20alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.210] synonym: "dehydrogenase, 3beta,20alpha-hydroxy steroid" EXACT [EC:1.1.1.210] synonym: "progesterone reductase activity" BROAD [EC:1.1.1.210] xref: EC:1.1.1.210 xref: GO:0047024 xref: MetaCyc:1.1.1.210-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006338 name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]." [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN] synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.212] synonym: "3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [] synonym: "3-oxoacyl-ACP reductase (NADH) activity" EXACT [] synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.1.1.212] synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.1.1.212] xref: EC:1.1.1.212 xref: GO:0047025 xref: MetaCyc:1.1.1.212-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006339 name: 3-alpha-hydroxysteroid dehydrogenase (A-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.213, MetaCyc:1.1.1.213-RXN] synonym: "3alpha-hydroxysteroid dehydrogenase (A-specific)" EXACT [EC:1.1.1.213] synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)" EXACT [EC:1.1.1.213] xref: EC:1.1.1.213 xref: GO:0047026 xref: MetaCyc:1.1.1.213-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006340 name: benzyl-2-methyl-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + benzyl (2R,3S)-2-methyl-3-hydroxybutanoate = NADPH + H+ + benzyl 2-methyl-3-oxobutanoate." [EC:1.1.1.217, MetaCyc:1.1.1.217-RXN] synonym: "benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.217] synonym: "benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.217] xref: EC:1.1.1.217 xref: GO:0047027 xref: MetaCyc:1.1.1.217-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006341 name: 6-pyruvoyltetrahydropterin 2'-reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin." [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN] subset: gosubset_prok synonym: "6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.220] synonym: "6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity" EXACT [EC:1.1.1.220] synonym: "6-pyruvoyl-tetrahydropterin 2'-reductase activity" EXACT [EC:1.1.1.220] synonym: "6-pyruvoyltetrahydropterin reductase activity" EXACT [EC:1.1.1.220] synonym: "6PPH4(2'-oxo) reductase activity" EXACT [EC:1.1.1.220] synonym: "pyruvoyl-tetrahydropterin reductase activity" EXACT [EC:1.1.1.220] xref: EC:1.1.1.220 xref: GO:0047028 xref: MetaCyc:1.1.1.220-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006343 name: 4-hydroxycyclohexanecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 4-hydroxycyclohexanecarboxylate = NADH + H+ + 4-oxocyclohexanecarboxylate." [EC:1.1.1.226, MetaCyc:1.1.1.226-RXN] synonym: "trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.226] synonym: "trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.226] xref: EC:1.1.1.226 xref: GO:0047030 xref: MetaCyc:1.1.1.226-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006344 name: diethyl 2-methyl-3-oxosuccinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + diethyl (2R,3R)-2-methyl-3-hydroxysuccinate = NADPH + H+ + diethyl-2-methyl-3-oxosuccinate." [EC:1.1.1.229, MetaCyc:1.1.1.229-RXN] synonym: "diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.229] xref: EC:1.1.1.229 xref: GO:0047031 xref: MetaCyc:1.1.1.229-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006345 name: 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 3-alpha-hydroxyglycyrrhetinate = NADPH + H+ + 3-oxoglycyrrhetinate." [EC:1.1.1.230, MetaCyc:1.1.1.230-RXN] synonym: "3alpha-hydroxyglycyrrhetinate dehydrogenase activity" EXACT [EC:1.1.1.230] synonym: "3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.230] xref: EC:1.1.1.230 xref: GO:0047032 xref: MetaCyc:1.1.1.230-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006346 name: 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-6,9-alpha-epoxy-11-alpha-hydroxy-15-oxoprosta-5,13-dienoate." [EC:1.1.1.231, MetaCyc:1.1.1.231-RXN] synonym: "(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.231] synonym: "NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.231] synonym: "NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity" EXACT [EC:1.1.1.231] synonym: "PG I2 dehydrogenase activity" EXACT [EC:1.1.1.231] synonym: "prostacyclin dehydrogenase activity" EXACT [EC:1.1.1.231] xref: EC:1.1.1.231 xref: GO:0047033 xref: MetaCyc:1.1.1.231-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006347 name: 15-hydroxyicosatetraenoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate." [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN] synonym: "(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity" EXACT [EC:1.1.1.232] synonym: "15-hydroxyeicosatetraenoate dehydrogenase activity" EXACT [EC:1.1.1.232] xref: EC:1.1.1.232 xref: GO:0047034 xref: MetaCyc:1.1.1.232-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006348 name: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + testosterone = NADH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.239, MetaCyc:1.1.1.239-RXN] synonym: "3alpha(17beta)-HSD" RELATED [EC:1.1.1.239] synonym: "3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)" EXACT [EC:1.1.1.239] synonym: "3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.239] synonym: "3alpha,17beta-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.239] xref: EC:1.1.1.239 xref: GO:0047035 xref: MetaCyc:1.1.1.239-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006349 name: codeinone reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + codeine = NADPH + H+ + codeinone." [EC:1.1.1.247, MetaCyc:1.1.1.247-RXN] synonym: "codeine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.247] xref: EC:1.1.1.247 xref: GO:0047036 xref: MetaCyc:1.1.1.247-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006350 name: salutaridine reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + salutaridinol = NADPH + H+ + salutaridine." [EC:1.1.1.248, MetaCyc:1.1.1.248-RXN] synonym: "salutaridinol:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.248] xref: EC:1.1.1.248 xref: GO:0047037 xref: MetaCyc:1.1.1.248-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006351 name: D-arabinitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + D-arabitol = NADH + H+ + D-ribulose." [EC:1.1.1.250, MetaCyc:1.1.1.250-RXN] synonym: "D-arabinitol 2-dehydrogenase (ribulose-forming) activity" EXACT [EC:1.1.1.250] synonym: "D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)" EXACT [EC:1.1.1.250] xref: EC:1.1.1.250 xref: GO:0047038 xref: MetaCyc:1.1.1.250-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006352 name: tetrahydroxynaphthalene reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol." [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN] synonym: "scytalone:NADP+ delta5-oxidoreductase activity" EXACT [EC:1.1.1.252] synonym: "T4HN reductase activity" EXACT [EC:1.1.1.252] xref: EC:1.1.1.252 xref: GO:0047039 xref: MetaCyc:1.1.1.252-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006353 name: pteridine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 NADP+ + tetra-hydro-biopterin = 2 NADPH + 2 H+ + biopterin." [EC:1.1.1.253, MetaCyc:1.1.1.253-RXN] comment: Note that this function was formerly EC:1.1.1.253. synonym: "5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.33] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "pteridine reductase 1 activity" NARROW [EC:1.5.1.33e] synonym: "PTR1" RELATED [EC:1.5.1.33] synonym: "ptr1 activity" NARROW [EC:1.5.1.33e] xref: EC:1.5.1.33 xref: GO:0047040 xref: MetaCyc:1.1.1.253-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006355 name: 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.50, MetaCyc:1.1.1.50-RXN] subset: gosubset_prok synonym: "3-alpha-HSD activity" EXACT [EC:1.1.1.50] synonym: "3alpha-HSD" RELATED [EC:1.1.1.50] synonym: "3alpha-hydroxysteroid dehydrogenase (B-specific)" EXACT [EC:1.1.1.50] synonym: "3alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.50] synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.50] synonym: "hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.50] synonym: "sterognost 3alpha" RELATED [EC:1.1.1.50] xref: EC:1.1.1.50 xref: GO:0047042 xref: MetaCyc:1.1.1.50-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006356 name: 3-alpha-hydroxycholanate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-cholanate = NADH + H+ + 3-oxo-5-beta-cholanate." [EC:1.1.1.52, MetaCyc:1.1.1.52-RXN] synonym: "3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.52] synonym: "3alpha-hydroxycholanate dehydrogenase activity" EXACT [EC:1.1.1.52] synonym: "alpha-hydroxy-cholanate dehydrogenase activity" EXACT [EC:1.1.1.52] xref: EC:1.1.1.52 xref: GO:0047043 xref: MetaCyc:1.1.1.52-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006357 name: 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+." [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN] subset: gosubset_prok synonym: "(R)-20-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53] synonym: "20beta-HSD" RELATED [EC:1.1.1.53] synonym: "20beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53] synonym: "3alpha(or 20beta)-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53] synonym: "3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.53] synonym: "3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity" EXACT [EC:1.1.1.53] synonym: "cortisone reductase activity" EXACT [EC:1.1.1.53] synonym: "dehydrogenase, 20beta-hydroxy steroid" EXACT [EC:1.1.1.53] synonym: "delta4-3-ketosteroid hydrogenase activity" EXACT [EC:1.1.1.53] synonym: "NADH-20beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53] xref: EC:1.1.1.53 xref: GO:0047044 xref: MetaCyc:1.1.1.53-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006358 name: testosterone 17-beta-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN] synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.64] synonym: "17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity" EXACT [EC:1.1.1.64] synonym: "NADP-dependent testosterone-17beta-oxidoreductase activity" EXACT [EC:1.1.1.64] synonym: "testosterone 17beta-dehydrogenase (NADP+)" EXACT [EC:1.1.1.64] xref: EC:1.1.1.64 xref: GO:0047045 xref: MetaCyc:1.1.1.64-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006359 name: homoisocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate." [EC:1.1.1.155, EC:1.1.1.87, MetaCyc:1.1.1.87-RXN] comment: Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical. synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87] synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] synonym: "2-hydroxy-3-carboxyadipate dehydrogenase activity" EXACT [EC:1.1.1.87] synonym: "3-carboxy-2-hydroxyadipate dehydrogenase activity" EXACT [] synonym: "3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87] synonym: "3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] synonym: "homoisocitric dehydrogenase activity" EXACT [EC:1.1.1.87] xref: EC:1.1.1.87 xref: GO:0047046 xref: GO:0047984 xref: MetaCyc:1.1.1.87-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006360 name: oxaloglycolate reductase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate." [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN] synonym: "D-glycerate:NAD(P)+ oxidoreductase (carboxylating)" EXACT [EC:1.1.1.92] xref: EC:1.1.1.92 xref: GO:0047047 xref: MetaCyc:1.1.1.92-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006361 name: 3-hydroxybenzyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 3-hydroxybenzyl alcohol = NADPH + H+ + 3-hydroxybenzaldehyde." [EC:1.1.1.97, MetaCyc:1.1.1.97-RXN] synonym: "3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.97] synonym: "m-hydroxybenzyl alcohol (NADP) dehydrogenase activity" EXACT [EC:1.1.1.97] synonym: "m-hydroxybenzyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.97] synonym: "m-hydroxybenzylalcohol dehydrogenase activity" EXACT [EC:1.1.1.97] xref: EC:1.1.1.97 xref: GO:0047048 xref: MetaCyc:1.1.1.97-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006364 name: D-lactate dehydrogenase (cytochrome c-553) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocytochrome C-553 + pyruvate." [EC:1.1.2.5, MetaCyc:1.1.2.5-RXN] synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" EXACT [EC:1.1.2.5] xref: EC:1.1.2.5 xref: GO:0047051 xref: MetaCyc:1.1.2.5-RXN is_a: CCO:F0003456 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: CCO:F0006367 name: berbamunine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + R-N-methylcoclaurine + S-N-methylcoclaurine = 2 H2O + NADP+ + berbamunine." [EC:1.14.21.3, MetaCyc:1.1.3.34-RXN] synonym: "(S)-N-methylcoclaurine oxidase (C-O phenol-coupling) activity" EXACT [EC:1.14.21.3] synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (C-O phenol-coupling)" EXACT [EC:1.14.21.3] xref: EC:1.14.21.3 xref: GO:0047054 xref: MetaCyc:1.1.3.34-RXN is_a: CCO:F0006310 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: CCO:F0006368 name: salutaridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + (R)-reticuline = 2 H2O + NADP+ + salutaridine." [EC:1.14.21.4, MetaCyc:1.1.3.35-RXN] synonym: "(R)-reticuline oxidase (C-C phenol-coupling) activity" EXACT [EC:1.14.21.4] synonym: "(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)" EXACT [EC:1.14.21.4] xref: EC:1.14.21.4 xref: GO:0047055 xref: MetaCyc:1.1.3.35-RXN is_a: CCO:F0006310 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: CCO:F0006370 name: vitamin-K-epoxide reductase (warfarin-sensitive) activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.1, MetaCyc:1.1.4.1-RXN] synonym: "2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.1] synonym: "phylloquinone epoxide reductase activity" EXACT [EC:1.1.4.1] synonym: "vitamin K1 epoxide reductase activity" NARROW [EC:1.1.4.1] xref: EC:1.1.4.1 xref: GO:0047057 xref: MetaCyc:1.1.4.1-RXN xref: Reactome:82285 is_a: CCO:F0003458 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor [Term] id: CCO:F0006371 name: vitamin-K-epoxide reductase (warfarin-insensitive) activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.2, MetaCyc:1.1.4.2-RXN] synonym: "3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.2] synonym: "vitamin K 2,3-epoxide reductase activity" EXACT [EC:1.1.4.2] xref: EC:1.1.4.2 xref: GO:0047058 xref: MetaCyc:1.1.4.2-RXN is_a: CCO:F0003458 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor [Term] id: CCO:F0006372 name: polyvinyl-alcohol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: acceptor + polyvinyl alcohol = donor-H2 + oxidized polyvinyl alcohol." [EC:1.1.99.23, MetaCyc:1.1.99.23-RXN] subset: gosubset_prok synonym: "polyvinyl-alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.23] synonym: "polyvinyl-alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.23] synonym: "PVA dehydrogenase activity" EXACT [EC:1.1.99.23] xref: EC:1.1.99.23 xref: GO:0047059 xref: MetaCyc:1.1.99.23-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0006374 name: glucose-fructose oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: fructose + beta-D-glucose = D-sorbitol + glucono-delta-lactone." [EC:1.1.99.28, MetaCyc:1.1.99.28-RXN] subset: gosubset_prok synonym: "D-glucose:D-fructose oxidoreductase activity" EXACT [EC:1.1.99.28] xref: EC:1.1.99.28 xref: GO:0047061 xref: MetaCyc:1.1.99.28-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0006375 name: trans-acenaphthene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + (+-)-trans-acenaphthene-1,2-diol = NADPH + H+ + acenaphthenequinone." [EC:1.10.1.1, MetaCyc:1.10.1.1-RXN] synonym: "(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.10.1.1] synonym: "trans-1,2-acenaphthenediol dehydrogenase activity" EXACT [EC:1.10.1.1] xref: EC:1.10.1.1 xref: GO:0047062 xref: MetaCyc:1.10.1.1-RXN is_a: CCO:F0003271 ! oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor [Term] id: CCO:F0006376 name: L-ascorbate-cytochrome-b5 reductase activity namespace: molecular_function def: "Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate." [EC:1.10.2.1, MetaCyc:1.10.2.1-RXN] synonym: "ascorbate-cytochrome b5 reductase activity" EXACT [EC:1.10.2.1] synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.10.2.1] xref: EC:1.10.2.1 xref: GO:0047063 xref: MetaCyc:1.10.2.1-RXN is_a: CCO:F0003272 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor [Term] id: CCO:F0006377 name: sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 2 sulochrin = 2 H2O + 2 (+)-bisdechlorogeodin." [EC:1.21.3.4, MetaCyc:1.10.3.7-RXN] synonym: "sulochrin oxidase activity" EXACT [EC:1.21.3.4] synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)" EXACT [EC:1.21.3.4] xref: EC:1.21.3.4 xref: GO:0047064 xref: MetaCyc:1.10.3.7-RXN is_a: CCO:F0006307 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: CCO:F0006378 name: sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 2 sulochrin = 2 H2O + 2 (-)-bisdechlorogeodin." [EC:1.21.3.5, MetaCyc:1.10.3.8-RXN] synonym: "sulochrin oxidase activity" BROAD [EC:1.21.3.5] synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)" EXACT [EC:1.21.3.5] xref: EC:1.21.3.5 xref: GO:0047065 xref: MetaCyc:1.10.3.8-RXN is_a: CCO:F0006307 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: CCO:F0006379 name: phospholipid-hydroperoxide glutathione peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN] synonym: "glutathione:lipid-hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.12] synonym: "hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12] synonym: "peroxidation-inhibiting protein activity" RELATED [EC:1.11.1.12] synonym: "peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)" EXACT [EC:1.11.1.12] synonym: "PHGPX" RELATED [EC:1.11.1.12] synonym: "phospholipid hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12] xref: EC:1.11.1.12 xref: GO:0047066 xref: MetaCyc:1.11.1.12-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0006380 name: hydrogen:quinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: menaquinone + H2 = reduced menaquinone." [EC:1.12.5.1, MetaCyc:1.12.99.3-RXN] subset: gosubset_prok synonym: "hydrogen-ubiquinone oxidoreductase activity" EXACT [EC:1.12.5.1] synonym: "hydrogen:menaquinone oxidoreductase activity" EXACT [EC:1.12.5.1] synonym: "membrane-bound hydrogenase activity" NARROW [EC:1.12.5.1] synonym: "quinone-reactive Ni/Fe-hydrogenase activity" RELATED [EC:1.12.5.1] xref: EC:1.12.5.1 xref: GO:0047067 xref: MetaCyc:1.12.5.1-RXN is_a: CCO:F0006308 ! oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor [Term] id: CCO:F0006381 name: N5,N10-methenyltetrahydromethanopterin hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2 + N5,N10-methenyltetrahydromethanopterin = H+ + N5,N10-methylenetetrahydromethanopterin." [EC:1.12.98.2, MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN-RXN] subset: gosubset_prok synonym: "5,10-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H(2)-dependent methylene-H(4)MPT dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H2-dependent methylene-H4MPT dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] synonym: "hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] synonym: "hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] synonym: "N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2] synonym: "N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [] synonym: "nonmetal hydrogenase activity" RELATED [EC:1.12.98.2] xref: EC:1.12.98.2 xref: GO:0016947 xref: GO:0047068 xref: MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN is_a: CCO:F0006309 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors [Term] id: CCO:F0006382 name: 7,8-dihydroxykynurenate 8,8a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 7,8-dihydroxykynurenate = 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate." [EC:1.13.11.10, MetaCyc:1.13.11.10-RXN] synonym: "7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity" EXACT [EC:1.13.11.10] synonym: "7,8-dihydroxykynurenate oxygenase activity" EXACT [EC:1.13.11.10] synonym: "7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.10] xref: EC:1.13.11.10 xref: GO:0047069 xref: MetaCyc:1.13.11.10-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006383 name: 3-carboxyethylcatechol 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate." [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN] synonym: "2,3-dihydroxy-beta-phenylpropionate oxygenase activity" EXACT [EC:1.13.11.16] synonym: "2,3-dihydroxy-beta-phenylpropionic dioxygenase activity" EXACT [EC:1.13.11.16] synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.16] synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.16] xref: EC:1.13.11.16 xref: GO:0047070 xref: MetaCyc:1.13.11.16-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006384 name: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate." [EC:1.13.11.25, MetaCyc:1.13.11.25-RXN] synonym: "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.25] synonym: "3-alkylcatechol 2,3-dioxygenase activity" EXACT [EC:1.13.11.25] synonym: "steroid 4,5-dioxygenase activity" BROAD [EC:1.13.11.25] xref: EC:1.13.11.25 xref: GO:0047071 xref: MetaCyc:1.13.11.25-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006385 name: 2,3-dihydroxybenzoate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 2,3-dihydroxybenzoate = 2-carboxy-cis,cis-muconate." [EC:1.13.11.28, MetaCyc:1.13.11.28-RXN] synonym: "2,3-dihydroxybenzoate 2,3-oxygenase activity" EXACT [EC:1.13.11.28] synonym: "2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.28] xref: EC:1.13.11.28 xref: GO:0047072 xref: MetaCyc:1.13.11.28-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006386 name: 2,4'-dihydroxyacetophenone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 2',4'-dihydroxyacetophenone = formate + p-hydroxybenzoate." [EC:1.13.11.41, MetaCyc:1.13.11.41-RXN] subset: gosubset_prok synonym: "(4-hydroxybenzoyl)methanol oxygenase activity" EXACT [EC:1.13.11.41] synonym: "2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.13.11.41] xref: EC:1.13.11.41 xref: GO:0047073 xref: MetaCyc:1.13.11.41-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006387 name: 4-hydroxycatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." [EC:1.13.11.-, MetaCyc:R308-RXN] xref: EC:1.13.11.- xref: GO:0047074 xref: MetaCyc:R308-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006388 name: 2,5-dihydroxypyridine 5,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate." [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN] synonym: "2,5-dihydroxypyridine oxygenase activity" EXACT [EC:1.13.11.9] synonym: "2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity" EXACT [EC:1.13.11.9] synonym: "pyridine-2,5-diol dioxygenase activity" EXACT [EC:1.13.11.9] xref: EC:1.13.11.9 xref: GO:0047075 xref: MetaCyc:1.13.11.9-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006389 name: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + pyrophosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN] synonym: "firefly luciferase activity" EXACT [EC:1.13.12.7] synonym: "firefly luciferin luciferase activity" EXACT [EC:1.13.12.7] synonym: "luciferase (firefly luciferin)" EXACT [EC:1.13.12.7] synonym: "luciferase activity" BROAD [EC:1.13.12.7] synonym: "Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)" EXACT [EC:1.13.12.7] synonym: "Photinus pyralis luciferase activity" EXACT [EC:1.13.12.7] synonym: "Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)" EXACT [EC:1.13.12.7] synonym: "Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)" EXACT [EC:1.13.12.7] xref: EC:1.13.12.7 xref: GO:0047077 xref: MetaCyc:1.13.12.7-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: CCO:F0006100 ! luciferin monooxygenase activity [Term] id: CCO:F0006390 name: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate." [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN] subset: gosubset_prok synonym: "(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] synonym: "1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [] synonym: "3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.47] synonym: "3-hydroxy-4(1H)-one, 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] synonym: "3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] synonym: "quinoline-3,4-diol 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] xref: EC:1.13.11.47 xref: GO:0047078 xref: MetaCyc:1.13.11.47-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006391 name: pyrimidine-deoxynucleoside 1'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 2-oxoglutarate + deoxyuridine = CO2 + succinate + dioxyribonolactone + uracil." [EC:1.14.11.10, MetaCyc:1.14.11.10-RXN] synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)" EXACT [EC:1.14.11.10] synonym: "deoxyuridine-uridine 1'-dioxygenase activity" EXACT [EC:1.14.11.10] synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity" EXACT [EC:1.14.11.10] xref: EC:1.14.11.10 xref: GO:0047079 xref: MetaCyc:1.14.11.10-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0006392 name: pyrimidine-deoxynucleoside 2'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 2-oxoglutarate + deoxyuridine = CO2 + succinate + uridine." [EC:1.14.11.3, MetaCyc:1.14.11.3-RXN] synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.11.3] synonym: "deoxyuridine 2'-dioxygenase activity" EXACT [EC:1.14.11.3] synonym: "deoxyuridine 2'-hydroxylase activity" EXACT [EC:1.14.11.3] synonym: "pyrimidine deoxyribonucleoside 2'-hydroxylase activity" EXACT [EC:1.14.11.3] synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity" EXACT [EC:1.14.11.3] synonym: "thymidine 2'-dioxygenase activity" NARROW [EC:1.14.11.3] synonym: "thymidine 2'-hydroxylase activity" NARROW [EC:1.14.11.3] synonym: "thymidine 2-oxoglutarate dioxygenase activity" NARROW [EC:1.14.11.3] synonym: "thymidine dioxygenase activity" NARROW [EC:1.14.11.3] xref: EC:1.14.11.3 xref: GO:0047080 xref: MetaCyc:1.14.11.3-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0006393 name: 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NAD(P)H + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NAD(P)+ + 2-(acetamidomethylene)succinate." [EC:1.14.12.4, MetaCyc:1.14.12.4-RXN] synonym: "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" EXACT [EC:1.14.12.4] synonym: "3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.4] synonym: "3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" EXACT [EC:1.14.12.4] synonym: "methylhydroxypyridine carboxylate dioxygenase activity" EXACT [EC:1.14.12.4] synonym: "methylhydroxypyridinecarboxylate oxidase activity" EXACT [EC:1.14.12.4] xref: EC:1.14.12.4 xref: GO:0047081 xref: MetaCyc:1.14.12.4-RXN is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0006394 name: 3,9-dihydroxypterocarpan 6a-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + (6aR,11aR)-3,9-dihydroxypterocarpan = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol." [EC:1.14.13.28, MetaCyc:1.14.13.28-RXN] synonym: "(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)" EXACT [EC:1.14.13.28] synonym: "3,9-dihydroxypterocarpan 6a-hydroxylase activity" EXACT [] synonym: "3,9-dihydroxypterocarpan 6alpha-monooxygenase (erroneous)" EXACT [EC:1.14.13.28] xref: EC:1.14.13.28 xref: GO:0047082 xref: MetaCyc:RXN-4505 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006395 name: 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate." [EC:1.14.13.36, MetaCyc:1.14.13.36-RXN] synonym: "5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity" EXACT [] synonym: "coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity" EXACT [EC:1.14.13.36] synonym: "trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.36] xref: EC:1.14.13.36 xref: GO:0047083 xref: MetaCyc:1.14.13.36-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006396 name: methyltetrahydroprotoberberine 14-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine." [EC:1.14.13.37, MetaCyc:1.14.13.37-RXN] synonym: "(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity" EXACT [EC:1.14.13.37] synonym: "(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity" EXACT [EC:1.14.13.37] synonym: "(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)" EXACT [EC:1.14.13.37] synonym: "methyltetrahydroprotoberberine 14-hydroxylase activity" EXACT [] xref: EC:1.14.13.37 xref: GO:0047084 xref: MetaCyc:1.14.13.37-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006397 name: hydroxyphenylacetonitrile 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + 4-hydroxyphenylacetonitrile = H2O + NADP+ + 4-hydroxymandelonitrile." [EC:1.14.13.42, MetaCyc:1.14.13.42-RXN] synonym: "4-hydroxyphenylacetonitrile hydroxylase activity" EXACT [EC:1.14.13.42] synonym: "4-hydroxyphenylacetonitrile monooxygenase activity" EXACT [] synonym: "4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.42] xref: EC:1.14.13.42 xref: GO:0047085 xref: MetaCyc:1.14.13.42-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006398 name: ketosteroid monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate." [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN] synonym: "17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)" EXACT [EC:1.14.13.54] synonym: "androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54] synonym: "ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54] synonym: "progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)" EXACT [EC:1.14.13.54] synonym: "steroid-ketone monooxygenase activity" EXACT [EC:1.14.13.54] xref: EC:1.14.13.54 xref: GO:0047086 xref: MetaCyc:1.14.13.54-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006399 name: protopine 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + protopine = H2O + NADP+ + 6-hydroxyprotopine." [EC:1.14.13.55, MetaCyc:1.14.13.55-RXN] synonym: "protopine 6-hydroxylase activity" EXACT [] synonym: "protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.55] xref: EC:1.14.13.55 xref: GO:0047087 xref: MetaCyc:1.14.13.55-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006400 name: dihydrosanguinarine 10-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + dihydrosanguinarine = H2O + NADP+ + 10-hydroxydihydrosanguinarine." [EC:1.14.13.56, MetaCyc:1.14.13.56-RXN] synonym: "dihydrosanguinarine 10-hydroxylase activity" EXACT [] synonym: "dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)" EXACT [EC:1.14.13.56] xref: EC:1.14.13.56 xref: GO:0047088 xref: MetaCyc:1.14.13.56-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006401 name: dihydrochelirubine 12-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + dihydrochelirubine = H2O + NADP+ + 10-hydroxydihydrochelirubine." [EC:1.14.13.57, MetaCyc:1.14.13.57-RXN] synonym: "dihydrochelirubine 12-hydroxylase activity" EXACT [] synonym: "dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.57] xref: EC:1.14.13.57 xref: GO:0047089 xref: MetaCyc:1.14.13.57-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006402 name: benzoyl-CoA 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + O2 + NADPH = H2O + NADP+ + 3-hydroxybenzoyl-CoA." [EC:1.14.13.58, MetaCyc:1.14.13.58-RXN] synonym: "benzoyl-CoA 3-hydroxylase activity" EXACT [] synonym: "benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.58] xref: EC:1.14.13.58 xref: GO:0047090 xref: MetaCyc:1.14.13.58-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006403 name: L-lysine 6-monooxygenase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + L-lysine = H2O + NADP+ + N6-hydroxy-L-lysine." [EC:1.14.13.59, MetaCyc:1.14.13.59-RXN] comment: Note that EC:1.13.12.10 was merged into this term. subset: gosubset_prok synonym: "L-lysine 6-monooxygenase activity" EXACT [] synonym: "L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.59] synonym: "lysine N(6)-hydroxylase activity" EXACT [EC:1.14.13.59] synonym: "lysine N6-hydroxylase activity" EXACT [] xref: EC:1.14.13.59 xref: GO:0008739 xref: GO:0047091 xref: MetaCyc:1.14.13.59-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006404 name: 27-hydroxycholesterol 7-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [EC:1.14.13.60, MetaCyc:1.14.13.60-RXN] synonym: "27-hydroxycholesterol 7-alpha-hydroxylase activity" EXACT [EC:1.14.13.60] synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT [] synonym: "27-hydroxycholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.60] synonym: "27-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.60] synonym: "27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.60] xref: EC:1.14.13.60 xref: GO:0047092 xref: MetaCyc:1.14.13.60-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006405 name: 4-hydroxyquinoline 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADH + quinolin-4-ol = H2O + NAD+ + quinolin-3,4-diol." [EC:1.14.13.62, MetaCyc:1.14.13.62-RXN] synonym: "1-H-4-oxoquinoline 3-monooxygenase activity" EXACT [EC:1.14.13.62] synonym: "quinolin-4(1H)-one 3-monooxygenase activity" EXACT [EC:1.14.13.62] synonym: "quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)" EXACT [EC:1.14.13.62] xref: EC:1.14.13.62 xref: GO:0047093 xref: MetaCyc:1.14.13.62-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006406 name: 3-hydroxyphenylacetate 6-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate." [EC:1.14.13.63, MetaCyc:1.14.13.63-RXN] synonym: "3-hydroxyphenylacetate 6-monooxygenase activity" EXACT [EC:1.14.13.63] synonym: "3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.63] xref: EC:1.14.13.63 xref: GO:0047094 xref: MetaCyc:1.14.13.63-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006407 name: 2-hydroxycyclohexanone 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + 2-hydroxycyclohexan-1-one = H2O + NADP+ + 6-hydroxyhexan-6-olide." [EC:1.14.13.66, MetaCyc:1.14.13.66-RXN] synonym: "2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.13.66] xref: EC:1.14.13.66 xref: GO:0047095 xref: MetaCyc:1.14.13.66-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006408 name: androst-4-ene-3,17-dione monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + donor-H2 + androst-4-ene-3,17-dione = H2O + acceptor + 3-oxo-13,17-secoandrost-4-eno-17,13-alpha-lactone." [EC:1.14.99.12, MetaCyc:1.14.99.12-RXN] synonym: "4-androstene-3,17-dione monooxygenase activity" EXACT [] synonym: "androst-4-ene-3,17-dione 17-oxidoreductase activity" EXACT [EC:1.14.99.12] synonym: "androst-4-ene-3,17-dione hydroxylase activity" EXACT [EC:1.14.99.12] synonym: "androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)" EXACT [EC:1.14.99.12] synonym: "androstene-3,17-dione hydroxylase activity" EXACT [] synonym: "androstenedione monooxygenase activity" EXACT [EC:1.14.99.12] xref: EC:1.14.99.12 xref: GO:0047096 xref: MetaCyc:1.14.99.12-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0006409 name: phylloquinone monooxygenase (2,3-epoxidizing) activity namespace: molecular_function def: "Catalysis of the reaction: O2 + donor-H2 + vitamin K1 = H2O + acceptor + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone." [EC:1.14.99.20, MetaCyc:1.14.99.20-RXN] synonym: "phylloquinone epoxidase activity" EXACT [EC:1.14.99.20] synonym: "phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.20] synonym: "vitamin K 2,3-epoxidase activity" EXACT [EC:1.14.99.20] synonym: "vitamin K epoxidase activity" EXACT [EC:1.14.99.20] synonym: "vitamin K1 epoxidase activity" EXACT [EC:1.14.99.20] xref: EC:1.14.99.20 xref: GO:0047097 xref: MetaCyc:1.14.99.20-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0006410 name: Latia-luciferin monooxygenase (demethylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin." [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN] synonym: "Latia luciferin monooxygenase (demethylating)" EXACT [EC:1.14.99.21] synonym: "Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.99.21] synonym: "luciferase (Latia luciferin)" EXACT [EC:1.14.99.21] xref: EC:1.14.99.21 xref: GO:0047098 xref: MetaCyc:1.14.99.21-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: CCO:F0006100 ! luciferin monooxygenase activity [Term] id: CCO:F0006411 name: CDP-4-dehydro-6-deoxyglucose reductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose." [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN] synonym: "CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.17.1.1] synonym: "CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity" EXACT [EC:1.17.1.1] synonym: "CDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.17.1.1] synonym: "CDP-4-keto-deoxy-glucose reductase activity" EXACT [EC:1.17.1.1] synonym: "cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity" EXACT [EC:1.17.1.1] synonym: "cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity" EXACT [EC:1.17.1.1] synonym: "NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity" EXACT [EC:1.17.1.1] xref: EC:1.17.1.1 xref: GO:0047099 xref: MetaCyc:1.17.1.1-RXN is_a: CCO:F0003308 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: CCO:F0006412 name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate." [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN] synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.13] synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13] synonym: "glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13] synonym: "NADP-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] synonym: "NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] synonym: "NADP-triose phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] synonym: "triosephosphate dehydrogenase (NADP(+)) activity" EXACT [EC:1.2.1.13] synonym: "triosephosphate dehydrogenase (NADP)" EXACT [EC:1.2.1.13] synonym: "triosephosphate dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.13] xref: EC:1.2.1.13 xref: GO:0047100 xref: MetaCyc:1.2.1.13-RXN is_a: CCO:F0002279 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: CCO:F0006413 name: 2-oxoisovalerate dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA." [EC:1.2.1.25, MetaCyc:1.2.1.25-RXN] synonym: "2-oxoisovalerate dehydrogenase activity" EXACT [EC:1.2.1.25] synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" EXACT [EC:1.2.1.25] xref: EC:1.2.1.25 xref: GO:0047101 xref: MetaCyc:1.2.1.25-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006414 name: aminomuconate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate." [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN] synonym: "2-aminomuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity" EXACT [EC:1.2.1.32] synonym: "2-hydroxymuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "2-hydroxymuconic acid semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "2-hydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] xref: EC:1.2.1.32 xref: GO:0047102 xref: MetaCyc:1.2.1.32-RXN xref: Reactome:82529 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006415 name: 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate." [EC:1.2.1.40, MetaCyc:1.2.1.40-RXN] synonym: "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity" EXACT [EC:1.2.1.40] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity" EXACT [EC:1.2.1.40] synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity" EXACT [EC:1.2.1.40] synonym: "cholestanetriol-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] synonym: "THAL-NAD oxidoreductase activity" EXACT [EC:1.2.1.40] synonym: "trihydroxydeoxycoprostanal dehydrogenase activity" EXACT [EC:1.2.1.40] xref: EC:1.2.1.40 xref: GO:0047103 xref: MetaCyc:1.2.1.40-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006416 name: hexadecanal dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + CoA + palmitaldehyde = NADH + palmityl-CoA." [EC:1.2.1.42, MetaCyc:1.2.1.42-RXN] synonym: "fatty acyl-CoA reductase activity" BROAD [EC:1.2.1.42] synonym: "hexadecanal:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.42] xref: EC:1.2.1.42 xref: GO:0047104 xref: MetaCyc:1.2.1.42-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006417 name: 4-trimethylammoniobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate." [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN] synonym: "4-N-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47] synonym: "4-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47] synonym: "4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.47] xref: EC:1.2.1.47 xref: GO:0047105 xref: MetaCyc:1.2.1.47-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006418 name: 4-hydroxyphenylacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate." [EC:1.2.1.53, MetaCyc:1.2.1.53-RXN] synonym: "4-HPAL dehydrogenase activity" EXACT [EC:1.2.1.53] synonym: "4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.53] xref: EC:1.2.1.53 xref: GO:0047106 xref: MetaCyc:1.2.1.53-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006419 name: gamma-guanidinobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + 4-guanidinobutanal = NADH + 4-guanidinobutanoate." [EC:1.2.1.54, MetaCyc:1.2.1.54-RXN] synonym: "4-guanidinobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.54] synonym: "4-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54] synonym: "alpha-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54] synonym: "GBAL dehydrogenase activity" EXACT [EC:1.2.1.54] xref: EC:1.2.1.54 xref: GO:0047107 xref: MetaCyc:1.2.1.54-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006422 name: phenylglyoxylate dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = NADH + CO2 + benzoyl-S-CoA." [EC:1.2.1.58, MetaCyc:1.2.1.58-RXN] synonym: "phenylglyoxylate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.58] xref: EC:1.2.1.58 xref: GO:0047110 xref: MetaCyc:1.2.1.58-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006423 name: formate dehydrogenase (cytochrome-c-553) activity namespace: molecular_function def: "Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2." [EC:1.2.2.3, MetaCyc:1.2.2.3-RXN] synonym: "formate dehydrogenase (cytochrome c-553)" EXACT [EC:1.2.2.3] synonym: "formate:ferricytochrome-c-553 oxidoreductase activity" EXACT [EC:1.2.2.3] xref: EC:1.2.2.3 xref: GO:0047111 xref: MetaCyc:1.2.2.3-RXN is_a: CCO:F0003224 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: CCO:F0006424 name: pyruvate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + phosphate + pyruvate = H2O2 + CO2 + acetylphosphate." [EC:1.2.3.3, MetaCyc:1.2.3.3-RXN] subset: gosubset_prok synonym: "phosphate-dependent pyruvate oxidase activity" EXACT [EC:1.2.3.3] synonym: "pyruvate:oxygen 2-oxidoreductase (phosphorylating)" EXACT [EC:1.2.3.3] synonym: "pyruvic oxidase activity" EXACT [EC:1.2.3.3] xref: EC:1.2.3.3 xref: GO:0047112 xref: MetaCyc:1.2.3.3-RXN is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0006425 name: aldehyde dehydrogenase (pyrroloquinoline-quinone) activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acceptor + an aldehyde = donor-H2 + an acid." [EC:1.2.99.3, MetaCyc:1.2.99.3-RXN] subset: gosubset_prok synonym: "aldehyde dehydrogenase (acceptor) activity" EXACT [EC:1.2.99.3] synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" EXACT [EC:1.2.99.3] xref: EC:1.2.99.3 xref: GO:0047113 xref: MetaCyc:1.2.99.3-RXN is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0006426 name: kynurenate-7,8-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 7,8-dihydro-7,8-dihydroxykynurenate = NADH + 7,8-dihydroxykynurenate." [EC:1.3.1.18, MetaCyc:1.3.1.18-RXN] synonym: "7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity" EXACT [EC:1.3.1.18] synonym: "7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.18] synonym: "7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity" EXACT [EC:1.3.1.18] xref: EC:1.3.1.18 xref: GO:0047114 xref: MetaCyc:1.3.1.18-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006427 name: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol." [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN] subset: gosubset_prok synonym: "dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.20] synonym: "trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.20] xref: EC:1.3.1.20 xref: GO:0047115 xref: MetaCyc:1.3.1.20-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006428 name: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol." [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN] synonym: "(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.25] synonym: "2-hydro-1,2-dihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.25] synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.25] synonym: "DHB dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "DHBDH activity" EXACT [EC:1.3.1.25] synonym: "dihydrodihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25] xref: EC:1.3.1.25 xref: GO:0047116 xref: MetaCyc:1.3.1.25-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006429 name: enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.39, MetaCyc:1.3.1.39-RXN] synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.3.1.39] synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity" EXACT [] synonym: "enoyl-ACP reductase (NADPH, A-specific) activity" EXACT [] synonym: "enoyl-ACp reductase activity" EXACT [EC:1.3.1.39] synonym: "enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.39] synonym: "enoyl-acyl-carrier-protein reductase (NADPH, A-specific)" EXACT [EC:1.3.1.39] xref: EC:1.3.1.39 xref: GO:0047117 xref: MetaCyc:1.3.1.39-RXN is_a: CCO:F0003232 ! enoyl-[acyl-carrier-protein] reductase activity [Term] id: CCO:F0006430 name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 2,6-dioxo-6-phenylhexanoate = NADPH + 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate." [EC:1.3.1.40, MetaCyc:1.3.1.40-RXN] synonym: "2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.40] synonym: "2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.40] xref: EC:1.3.1.40 xref: GO:0047118 xref: MetaCyc:1.3.1.40-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006431 name: 2-methyl-branched-chain-enoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 2-methylbutyryl-CoA = NADH + 2-methylcrotonoyl-CoA." [EC:1.3.1.52, MetaCyc:1.3.1.52-RXN] synonym: "2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase activity" EXACT [EC:1.3.1.52] xref: EC:1.3.1.52 xref: GO:0047119 xref: MetaCyc:1.3.1.52-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006433 name: isoquinoline 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acceptor + isoquinoline = donor-H2 + isoquinolin-12H-one." [EC:1.3.99.16, MetaCyc:1.3.99.16-RXN] subset: gosubset_prok synonym: "isoquinoline:acceptor 1-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.16] xref: EC:1.3.99.16 xref: GO:0047121 xref: MetaCyc:1.3.99.16-RXN is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0006434 name: quinaldate 4-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acceptor + quinaldate = donor-H2 + kynurenate." [EC:1.3.99.18, MetaCyc:1.3.99.18-RXN] synonym: "quinaldic acid 4-oxidoreductase activity" EXACT [EC:1.3.99.18] synonym: "quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.18] xref: EC:1.3.99.18 xref: GO:0047122 xref: MetaCyc:1.3.99.18-RXN is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0006435 name: quinoline-4-carboxylate 2-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acceptor + quinoline-4-carboxylate = quinolin-2-ol + donor-H2." [EC:1.3.99.19, MetaCyc:1.3.99.19-RXN] synonym: "quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.19] synonym: "quinoline-4-carboxylic acid 2-oxidoreductase activity" EXACT [EC:1.3.99.19] xref: EC:1.3.99.19 xref: GO:0047123 xref: MetaCyc:1.3.99.19-RXN is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0006436 name: L-erythro-3,5-diaminohexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O + (3S,5S)-3,5-diaminohexanoate = NADH + NH3 + (S)-5-amino-3-oxohexanoate." [EC:1.4.1.11, MetaCyc:1.4.1.11-RXN] synonym: "L-3,5-diaminohexanoate dehydrogenase activity" EXACT [EC:1.4.1.11] synonym: "L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.11] xref: EC:1.4.1.11 xref: GO:0047124 xref: MetaCyc:1.4.1.11-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006437 name: delta1-piperideine-2-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta(1)-piperideine-2-carboxylate." [EC:1.5.1.21, MetaCyc:1.5.1.21-RXN] synonym: "1,2-didehydropipecolate reductase activity" EXACT [EC:1.5.1.21] synonym: "1,2-didehydropipecolic reductase activity" EXACT [EC:1.5.1.21] synonym: "D1-piperideine-2-carboxylate reductase activity" EXACT [] synonym: "delta 1-piperideine-2-carboxylate reductase activity" EXACT [] synonym: "L-pipecolate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.5.1.21] synonym: "P2C reductase activity" EXACT [EC:1.5.1.21] xref: EC:1.5.1.21 xref: GO:0047125 xref: MetaCyc:1.5.1.21-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006438 name: N5-(carboxyethyl)ornithine synthase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NADP+ + N5-(L-1-carboxyethyl)-L-ornithine = NADPH + pyruvate + L-ornithine." [EC:1.5.1.24, MetaCyc:1.5.1.24-RXN] subset: gosubset_prok synonym: "5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24] synonym: "N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24] xref: EC:1.5.1.24 xref: GO:0047126 xref: MetaCyc:1.5.1.24-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006439 name: thiomorpholine-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate." [EC:1.5.1.25, MetaCyc:1.5.1.25-RXN] synonym: "ketimine reductase activity" EXACT [EC:1.5.1.25] synonym: "ketimine-reducing enzyme" RELATED [EC:1.5.1.25] synonym: "thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity" EXACT [EC:1.5.1.25] xref: EC:1.5.1.25 xref: GO:0047127 xref: MetaCyc:1.5.1.25-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006440 name: 1,2-dehydroreticulinium reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + 1,2-dehydroreticulinium = NADP+ + R-reticuline." [EC:1.5.1.27, MetaCyc:1.5.1.27-RXN] synonym: "(R)-reticuline:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.27] synonym: "1,2-dehydroreticulinium ion reductase activity" EXACT [EC:1.5.1.27] xref: EC:1.5.1.27 xref: GO:0047128 xref: MetaCyc:1.5.1.27-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006441 name: opine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate = NADH + pyruvate + L-2-aminopentanoic acid." [EC:1.5.1.28, MetaCyc:1.5.1.28-RXN] subset: gosubset_prok synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)" EXACT [EC:1.5.1.28] synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)" EXACT [EC:1.5.1.28] xref: EC:1.5.1.28 xref: GO:0047129 xref: MetaCyc:1.5.1.28-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006442 name: saccharopine dehydrogenase (NADP+, L-lysine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+." [EC:1.5.1.8, MetaCyc:1.5.1.8-RXN] subset: gosubset_prok synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8] synonym: "L-lysine-alpha-ketoglutarate reductase activity" EXACT [EC:1.5.1.8] synonym: "lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)" EXACT [EC:1.5.1.8] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8] synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity" EXACT [EC:1.5.1.8] xref: EC:1.5.1.8 xref: GO:0010010 xref: GO:0047130 xref: MetaCyc:1.5.1.8-RXN is_a: CCO:F0001117 ! saccharopine dehydrogenase activity [Term] id: CCO:F0006443 name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: 6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+." [EC:1.5.1.9, MetaCyc:1.5.1.9-RXN] synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9] synonym: "aminoadipic semialdehyde synthase activity" EXACT [EC:1.5.1.9] synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)" EXACT [EC:1.5.1.9] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9] synonym: "NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)" EXACT [EC:1.5.1.9] synonym: "saccharopin dehydrogenase activity" EXACT [EC:1.5.1.9] xref: EC:1.5.1.9 xref: GO:0047131 xref: MetaCyc:1.5.1.9-RXN is_a: CCO:F0001117 ! saccharopine dehydrogenase activity [Term] id: CCO:F0006444 name: dihydrobenzophenanthridine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine." [EC:1.5.3.12, MetaCyc:1.5.3.12-RXN] synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.12] xref: EC:1.5.3.12 xref: GO:0047132 xref: MetaCyc:1.5.3.12-RXN is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0006445 name: dimethylamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine." [EC:1.5.8.1, MetaCyc:1.5.8.1-RXN] subset: gosubset_prok synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activity" EXACT [EC:1.5.8.1] synonym: "DMADh activity" EXACT [EC:1.5.8.1] xref: EC:1.5.8.1 xref: GO:0047133 xref: MetaCyc:1.5.8.1-RXN is_a: CCO:F0006311 ! oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor [Term] id: CCO:F0006446 name: protein-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN] subset: gosubset_prok synonym: "disulfide reductase activity" EXACT [EC:1.8.1.8] synonym: "insulin-glutathione transhydrogenase activity" EXACT [EC:1.8.1.8] synonym: "NAD(P)H2:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8] synonym: "NAD(P)H:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8] synonym: "protein disulfide reductase activity" EXACT [EC:1.8.1.8] synonym: "protein disulphide reductase activity" EXACT [EC:1.8.1.8] synonym: "protein-disulfide reductase (NAD(P)H) activity" EXACT [] synonym: "protein-disulphide reductase activity" EXACT [] synonym: "protein-dithiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.8] xref: EC:1.8.1.8 xref: GO:0047134 xref: MetaCyc:1.6.4.4-RXN is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006447 name: bis-gamma-glutamylcystine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 gamma-glutamylcysteine + NADP+ = bis-gamma-glutamylcystine + NADPH + H+." [EC:1.8.1.13, MetaCyc:1.6.4.9-RXN] synonym: "bis-g-glutamylcystine reductase (NADPH) activity" EXACT [] synonym: "Bis-gamma-glutamylcystine reductase (NADPH)" EXACT [EC:1.8.1.13] synonym: "bis-gamma-glutamylcystine reductase (NADPH) activity" EXACT [EC:1.8.1.13] synonym: "gamma-glutamylcysteine:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.13] synonym: "NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13] synonym: "NADPH:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13] xref: EC:1.8.1.13 xref: GO:0047135 xref: MetaCyc:1.6.4.9-RXN is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006448 name: 4-(dimethylamino)phenylazoxybenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-dimethylaminophenylazobenzene + NADP+ = 4-(dimethylamino)phenylazoxybenzene + NADPH + H+." [EC:1.7.1.11, MetaCyc:1.6.6.12-RXN] synonym: "4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.11] synonym: "dimethylaminoazobenzene N-oxide reductase activity" EXACT [EC:1.7.1.11] synonym: "N,N-dimethyl-p-aminoazobenzene oxide reductase activity" EXACT [EC:1.7.1.11] synonym: "NADPH-dependent DMAB N-oxide reductase activity" EXACT [EC:1.7.1.11] synonym: "NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11] synonym: "NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11] xref: EC:1.7.1.11 xref: GO:0047136 xref: MetaCyc:1.6.6.12-RXN is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0006449 name: N-hydroxy-2-acetamidofluorene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+." [EC:1.7.1.12, MetaCyc:1.7.1.12-RXN] synonym: "2-acetamidofluorene:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.12] synonym: "N-hydroxy-2-acetylaminofluorene reductase activity" EXACT [EC:1.7.1.12] synonym: "NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12] synonym: "NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12] xref: EC:1.7.1.12 xref: GO:0047137 xref: MetaCyc:1.7.1.12-RXN is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0006450 name: aquacobalamin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+." [EC:1.16.1.3, MetaCyc:1.6.99.12-RXN] subset: gosubset_prok synonym: "aquocobalamin reductase activity" EXACT [EC:1.16.1.3] synonym: "B(12a) reductase activity" EXACT [EC:1.16.1.3] synonym: "B12a reductase activity" EXACT [EC:1.16.1.3] synonym: "cob(II)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.3] synonym: "NADH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.3] synonym: "NADH2:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3] synonym: "NADH:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3] synonym: "vitamin B(12a) reductase activity" EXACT [EC:1.16.1.3] synonym: "vitamin B12a reductase activity" EXACT [EC:1.16.1.3] xref: EC:1.16.1.3 xref: GO:0047138 xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-RXN is_a: CCO:F0003305 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: CCO:F0006451 name: glutathione-homocystine transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine." [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN] synonym: "glutathione:homocystine oxidoreductase activity" EXACT [EC:1.8.4.1] xref: EC:1.8.4.1 xref: GO:0047139 xref: MetaCyc:1.8.4.1-RXN is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0006452 name: glutathione-CoA-glutathione transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione." [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN] synonym: "CoA:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3] synonym: "coenzyme A:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3] synonym: "coenzyme A:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.4.3] synonym: "glutathione coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3] synonym: "glutathione-coenzyme A glutathione disulfide transhydrogenase activity" EXACT [EC:1.8.4.3] synonym: "glutathione:coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3] xref: EC:1.8.4.3 xref: GO:0047140 xref: MetaCyc:1.8.4.3-RXN is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0006453 name: glutathione-cystine transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine." [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN] synonym: "glutathione:cystine oxidoreductase" EXACT [EC:1.8.4.4] synonym: "GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4] synonym: "NADPH-dependent GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4] xref: EC:1.8.4.4 xref: GO:0047141 xref: MetaCyc:1.8.4.4-RXN is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0006454 name: enzyme-thiol transhydrogenase (glutathione-disulfide) activity namespace: molecular_function def: "Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase." [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN] synonym: "[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "enzyme-thiol transhydrogenase (glutathione-disulphide) activity" EXACT [] synonym: "enzyme-thiol transhydrogenase (oxidized-glutathione) activity" EXACT [] synonym: "glutathione-dependent thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "thiol:disulphide oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7] xref: EC:1.8.4.7 xref: GO:0047142 xref: MetaCyc:1.8.4.7-RXN is_a: CCO:F0003264 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: CCO:F0006455 name: chlorate reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlorate + donor-H2 = chlorite + H2O + acceptor." [EC:1.97.1.1, MetaCyc:1.97.1.1-RXN] subset: gosubset_prok synonym: "chlorate reductase C" RELATED [EC:1.97.1.1] synonym: "chlorite:acceptor oxidoreductase activity" EXACT [EC:1.97.1.1] xref: EC:1.97.1.1 xref: GO:0047143 xref: MetaCyc:1.97.1.1-RXN is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0006456 name: 2-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [EC:2.3.1.52, MetaCyc:2-ACYL2.3.1.15-RXN] synonym: "2-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.52] synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.52] xref: EC:2.3.1.52 xref: GO:0047144 xref: MetaCyc:2-ACYL2.3.1.15-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006457 name: demethylsterigmatocystin 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.109, MetaCyc:2.1.1.109-RXN] synonym: "demethylsterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.109] synonym: "O-methyltransferase I" RELATED [EC:2.1.1.109] synonym: "S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity" EXACT [EC:2.1.1.109] xref: EC:2.1.1.109 xref: GO:0047145 xref: MetaCyc:2.1.1.109-RXN is_a: CCO:F0001758 ! O-methyltransferase activity [Term] id: CCO:F0006458 name: sterigmatocystin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.110, MetaCyc:2.1.1.110-RXN] synonym: "O-methyltransferase II activity" RELATED [EC:2.1.1.110] synonym: "S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity" EXACT [EC:2.1.1.110] synonym: "S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110] synonym: "sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110] synonym: "sterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.110] xref: EC:2.1.1.110 xref: GO:0047146 xref: MetaCyc:2.1.1.110-RXN is_a: CCO:F0001758 ! O-methyltransferase activity [Term] id: CCO:F0006459 name: trimethylsulfonium-tetrahydrofolate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: THF + trimethyl sulfonium = 5-methyl-THF + dimethyl sulfide." [EC:2.1.1.19, MetaCyc:2.1.1.19-RXN] synonym: "trimethylsulfonium-tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.19] synonym: "trimethylsulfonium:tetrahydrofolate N-methyltransferase activity" EXACT [EC:2.1.1.19] synonym: "trimethylsulphonium-tetrahydrofolate N-methyltransferase activity" EXACT [] xref: EC:2.1.1.19 xref: GO:0047147 xref: MetaCyc:2.1.1.19-RXN is_a: CCO:F0001757 ! N-methyltransferase activity [Term] id: CCO:F0006460 name: methylamine-glutamate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + methylamine = N-methyl-L-glutamate + NH3." [EC:2.1.1.21, MetaCyc:2.1.1.21-RXN] synonym: "methylamine-glutamate methyltransferase activity" EXACT [EC:2.1.1.21] synonym: "methylamine:L-glutamate N-methyltransferase activity" EXACT [EC:2.1.1.21] synonym: "N-methylglutamate synthase activity" EXACT [EC:2.1.1.21] xref: EC:2.1.1.21 xref: GO:0047148 xref: MetaCyc:2.1.1.21-RXN is_a: CCO:F0001757 ! N-methyltransferase activity [Term] id: CCO:F0006461 name: thetin-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homocysteine + dimethylsulfonioacetate = L-methionine + S-methylthioglycolate." [EC:2.1.1.3, MetaCyc:2.1.1.3-RXN] synonym: "dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.3] synonym: "dimethylthetin-homocysteine methyltransferase activity" EXACT [EC:2.1.1.3] synonym: "thetin-homocysteine methylpherase activity" EXACT [EC:2.1.1.3] xref: EC:2.1.1.3 xref: GO:0047149 xref: MetaCyc:2.1.1.3-RXN is_a: CCO:F0001759 ! S-methyltransferase activity [Term] id: CCO:F0006462 name: betaine-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homocysteine + betaine = L-methionine + dimethylglycine." [EC:2.1.1.5, MetaCyc:2.1.1.5-RXN] synonym: "betaine-homocysteine methyltransferase activity" EXACT [EC:2.1.1.5] synonym: "betaine-homocysteine transmethylase activity" EXACT [EC:2.1.1.5] synonym: "trimethylammonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.5] xref: EC:2.1.1.5 xref: GO:0047150 xref: MetaCyc:2.1.1.5-RXN is_a: CCO:F0001759 ! S-methyltransferase activity [Term] id: CCO:F0006463 name: methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity namespace: molecular_function def: "Catalysis of the reaction: FADH + H+ + tRNA U(psi)C = FAD+ + tRNA T(psi)C + THF." [EC:2.1.1.74, MetaCyc:2.1.1.74-RXN] synonym: "5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.74] synonym: "5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity" EXACT [EC:2.1.1.74] synonym: "folate-dependent ribothymidyl synthase activity" EXACT [EC:2.1.1.74] synonym: "methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity" EXACT [EC:2.1.1.74] synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity" EXACT [] xref: EC:2.1.1.74 xref: GO:0047151 xref: MetaCyc:2.1.1.74-RXN is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0006464 name: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide." [EC:2.1.1.90, MetaCyc:2.1.1.90-RXN] comment: This function is the first step in the pathway of methanogenesis from methanol. subset: gosubset_prok synonym: "methanol cobalamin methyltransferase activity" EXACT [EC:2.1.1.90] synonym: "methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity" EXACT [EC:2.1.1.90] synonym: "methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity" EXACT [EC:2.1.1.90] synonym: "methanol:corrinoid methyltransferase activity" EXACT [] synonym: "methyltransferase 1" BROAD [] synonym: "MT 1" RELATED [EC:2.1.1.90] synonym: "MT1" RELATED [] synonym: "MtaB" RELATED [] xref: EC:2.1.1.90 xref: GO:0047152 xref: MetaCyc:2.1.1.90-RXN is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0006465 name: deoxycytidylate 5-hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate." [EC:2.1.2.8, MetaCyc:2.1.2.8-RXN] synonym: "5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity" EXACT [EC:2.1.2.8] synonym: "d-cytidine 5'-monophosphate hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "dCMP hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "deoxyCMP hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "deoxycytidylate hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "deoxycytidylate hydroxymethyltransferase activity" EXACT [] synonym: "deoxycytidylic hydroxymethylase activity" EXACT [EC:2.1.2.8] xref: EC:2.1.2.8 xref: GO:0047153 xref: MetaCyc:2.1.2.8-RXN is_a: CCO:F0003318 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: CCO:F0006466 name: methylmalonyl-CoA carboxytransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA." [EC:2.1.3.1, MetaCyc:2.1.3.1-RXN] subset: gosubset_prok synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate" RELATED [EC:2.1.3.1] synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1] synonym: "(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1] synonym: "(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity" EXACT [EC:2.1.3.1] synonym: "methylmalonyl coenzyme A carboxyltransferase activity" EXACT [EC:2.1.3.1] synonym: "methylmalonyl-CoA carboxyltransferase activity" EXACT [] synonym: "methylmalonyl-CoA transcarboxylase activity" EXACT [EC:2.1.3.1] synonym: "oxalacetic transcarboxylase activity" EXACT [EC:2.1.3.1] synonym: "transcarboxylase activity" RELATED [EC:2.1.3.1] xref: EC:2.1.3.1 xref: GO:0047154 xref: MetaCyc:2.1.3.1-RXN is_a: CCO:F0003319 ! carboxyl- or carbamoyltransferase activity [Term] id: CCO:F0006467 name: 3-hydroxymethylcephem carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem." [EC:2.1.3.7, MetaCyc:2.1.3.7-RXN] synonym: "3'-hydroxymethylcephem-O-carbamoyltransferase activity" EXACT [] synonym: "carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity" EXACT [EC:2.1.3.7] xref: EC:2.1.3.7 xref: GO:0045447 xref: GO:0047155 xref: MetaCyc:2.1.3.7-RXN is_a: CCO:F0003319 ! carboxyl- or carbamoyltransferase activity [Term] id: CCO:F0006468 name: acetoin-ribose-5-phosphate transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: ribose-5-phosphate + 3-hydroxybutan-2-one = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde." [EC:2.2.1.4, MetaCyc:2.2.1.4-RXN] synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthase activity" EXACT [EC:2.2.1.4] synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthetase activity" EXACT [EC:2.2.1.4] synonym: "3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4] synonym: "3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4] xref: EC:2.2.1.4 xref: GO:0047156 xref: MetaCyc:2.2.1.4-RXN is_a: CCO:F0003320 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: CCO:F0006469 name: myelin-proteolipid O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA." [EC:2.3.1.100, MetaCyc:2.3.1.100-RXN] synonym: "[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100] synonym: "acyl-protein synthase activity" BROAD [EC:2.3.1.100] synonym: "myelin PLP acyltransferase activity" EXACT [EC:2.3.1.100] synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100] xref: EC:2.3.1.100 xref: GO:0047157 xref: MetaCyc:2.3.1.100-RXN is_a: CCO:F0003139 ! O-palmitoyltransferase activity [Term] id: CCO:F0006470 name: sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucoside = 1,2-bis-O-sinapoyl beta-D-glucoside + beta-D-glucose." [EC:2.3.1.103, MetaCyc:2.3.1.103-RXN] synonym: "1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103] synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity" EXACT [EC:2.3.1.103] synonym: "hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103] xref: EC:2.3.1.103 xref: GO:0047158 xref: MetaCyc:2.3.1.103-RXN is_a: CCO:F0003328 ! O-sinapoyltransferase activity [Term] id: CCO:F0006471 name: 1-alkenylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA." [EC:2.3.1.104, MetaCyc:2.3.1.104-RXN] synonym: "acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.104] xref: EC:2.3.1.104 xref: GO:0047159 xref: MetaCyc:2.3.1.104-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006472 name: alkylglycerophosphate 2-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA." [EC:2.3.1.105, MetaCyc:2.3.1.105-RXN] synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity" EXACT [EC:2.3.1.105] synonym: "alkyllyso-GP:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.105] xref: EC:2.3.1.105 xref: GO:0047160 xref: MetaCyc:2.3.1.105-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0006473 name: tartronate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxymalonate + sinapoyl-CoA = sinapoyltartronate + CoA." [EC:2.3.1.106, MetaCyc:2.3.1.106-RXN] synonym: "hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.106] synonym: "sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.106] synonym: "tartronate sinapoyltransferase activity" EXACT [EC:2.3.1.106] xref: EC:2.3.1.106 xref: GO:0047161 xref: MetaCyc:2.3.1.106-RXN is_a: CCO:F0008005 ! O-hydroxycinnamoyltransferase activity [Term] id: CCO:F0006474 name: 17-O-deacetylvindoline O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 17-O-deacetylvindoline + acetyl-CoA = vindoline + CoA." [EC:2.3.1.107, MetaCyc:2.3.1.107-RXN] synonym: "17-O-deacetylvindoline-17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "DAT activity" EXACT [EC:2.3.1.107] synonym: "deacetylvindoline acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107] xref: EC:2.3.1.107 xref: GO:0047162 xref: MetaCyc:2.3.1.107-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0006475 name: 3,4-dichloroaniline N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonate + CoA." [EC:2.3.1.114, MetaCyc:2.3.1.114-RXN] synonym: "malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity" EXACT [EC:2.3.1.114] xref: EC:2.3.1.114 xref: GO:0047163 xref: MetaCyc:2.3.1.114-RXN is_a: CCO:F0008003 ! N-malonyltransferase activity [Term] id: CCO:F0006476 name: isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA." [EC:2.3.1.115, MetaCyc:2.3.1.115-RXN] synonym: "flavone (flavonol) 7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "MAT-7" RELATED [EC:2.3.1.115] xref: EC:2.3.1.115 xref: GO:0047164 xref: MetaCyc:2.3.1.115-RXN is_a: CCO:F0008004 ! O-malonyltransferase activity [Term] id: CCO:F0006477 name: flavonol-3-O-beta-glucoside O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA." [EC:2.3.1.116, MetaCyc:2.3.1.116-RXN] synonym: "flavonol 3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116] synonym: "malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.116] synonym: "malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116] synonym: "MAT-3" RELATED [EC:2.3.1.116] xref: EC:2.3.1.116 xref: GO:0047165 xref: MetaCyc:2.3.1.116-RXN is_a: CCO:F0008004 ! O-malonyltransferase activity [Term] id: CCO:F0006478 name: 1-alkenylglycerophosphoethanolamine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA." [EC:2.3.1.121, MetaCyc:2.3.1.121-RXN] synonym: "acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.121] xref: EC:2.3.1.121 xref: GO:0047166 xref: MetaCyc:2.3.1.121-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006479 name: 1-alkyl-2-acetylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA." [EC:2.3.1.125, MetaCyc:2.3.1.125-RXN] synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" EXACT [EC:2.3.1.125] synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.125] xref: EC:2.3.1.125 xref: GO:0047167 xref: MetaCyc:2.3.1.125-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006480 name: isocitrate O-dihydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: threo-d(s)-iso-citrate + caffeoyl-CoA = 2-caffeoylisocitrate + CoA." [EC:2.3.1.126, MetaCyc:2.3.1.126-RXN] synonym: "caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.126] xref: EC:2.3.1.126 xref: GO:0047168 xref: MetaCyc:2.3.1.126-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006481 name: galactarate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-CoA + D-galactarate = O-feruloylgalactarate + CoA." [EC:2.3.1.130, MetaCyc:2.3.1.130-RXN] synonym: "feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.130] synonym: "galacturate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.130] xref: EC:2.3.1.130 xref: GO:0047169 xref: MetaCyc:2.3.1.130-RXN is_a: CCO:F0008005 ! O-hydroxycinnamoyltransferase activity [Term] id: CCO:F0006482 name: glucarate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate + sinapoyl-CoA = O-sinapoylglucarate + CoA." [EC:2.3.1.131, MetaCyc:2.3.1.131-RXN] synonym: "sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.131] xref: EC:2.3.1.131 xref: GO:0047170 xref: MetaCyc:2.3.1.131-RXN is_a: CCO:F0008005 ! O-hydroxycinnamoyltransferase activity [Term] id: CCO:F0006483 name: glucarolactone O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA." [EC:2.3.1.132, MetaCyc:2.3.1.132-RXN] synonym: "sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.132] xref: EC:2.3.1.132 xref: GO:0047171 xref: MetaCyc:2.3.1.132-RXN is_a: CCO:F0008005 ! O-hydroxycinnamoyltransferase activity [Term] id: CCO:F0006484 name: shikimate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA." [EC:2.3.1.133, MetaCyc:2.3.1.133-RXN] synonym: "4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.133] synonym: "shikimate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.133] xref: EC:2.3.1.133 xref: GO:0047172 xref: MetaCyc:2.3.1.133-RXN is_a: CCO:F0008005 ! O-hydroxycinnamoyltransferase activity [Term] id: CCO:F0006485 name: phosphatidylcholine-retinol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine." [EC:2.3.1.135, MetaCyc:2.3.1.135-RXN] synonym: "lecithin--retinol acyltransferase activity" EXACT [EC:2.3.1.135] synonym: "phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity" EXACT [EC:2.3.1.135] synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity" EXACT [EC:2.3.1.135] xref: EC:2.3.1.135 xref: GO:0047173 xref: MetaCyc:2.3.1.135-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006486 name: putrescine N-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: putrescine + caffeoyl-CoA = N-caffeoylputrescine + CoA." [EC:2.3.1.138, MetaCyc:2.3.1.138-RXN] synonym: "caffeoyl-CoA putrescine N-caffeoyl transferase activity" EXACT [EC:2.3.1.138] synonym: "caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.138] synonym: "hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138] synonym: "PHT" RELATED [EC:2.3.1.138] synonym: "putrescine hydroxycinnamoyl transferase activity" EXACT [EC:2.3.1.138] synonym: "putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138] xref: EC:2.3.1.138 xref: GO:0047174 xref: MetaCyc:2.3.1.138-RXN is_a: CCO:F0003133 ! N-acyltransferase activity is_a: CCO:F0008002 ! hydroxycinnamoyltransferase activity [Term] id: CCO:F0006487 name: galactosylacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]." [EC:2.3.1.141, MetaCyc:2.3.1.141-RXN] synonym: "acyl-ACP:lyso-MGDG acyltransferase activity" EXACT [EC:2.3.1.141] synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.141] synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.141] xref: EC:2.3.1.141 xref: GO:0047175 xref: MetaCyc:2.3.1.141-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006488 name: beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + beta-D-glucose." [EC:2.3.1.143, MetaCyc:2.3.1.143-RXN] synonym: "1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] synonym: "beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity" EXACT [EC:2.3.1.143] synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] xref: EC:2.3.1.143 xref: GO:0047176 xref: MetaCyc:2.3.1.143-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006489 name: glycerophospholipid arachidonoyl-transferase (CoA-independent) activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.147, MetaCyc:2.3.1.147-RXN] synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147] synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147] xref: EC:2.3.1.147 xref: GO:0047177 xref: MetaCyc:2.3.1.147-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006490 name: glycerophospholipid acyltransferase (CoA-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.148, MetaCyc:2.3.1.148-RXN] synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" EXACT [EC:2.3.1.148] xref: EC:2.3.1.148 xref: GO:0047178 xref: MetaCyc:2.3.1.148-RXN is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0006491 name: platelet-activating factor acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid." [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN] synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity" EXACT [EC:2.3.1.149] synonym: "PAF acetyltransferase activity" EXACT [] xref: EC:2.3.1.149 xref: GO:0047179 xref: MetaCyc:2.3.1.149-RXN is_a: CCO:F0003130 ! acetyltransferase activity [Term] id: CCO:F0006492 name: salutaridinol 7-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: salutaridinol + acetyl-CoA = 7-O-acetylsalutaridinol + CoA." [EC:2.3.1.150, MetaCyc:2.3.1.150-RXN] synonym: "acetyl-CoA:salutaridinol 7-O-acetyltransferase activity" EXACT [EC:2.3.1.150] xref: EC:2.3.1.150 xref: GO:0047180 xref: MetaCyc:2.3.1.150-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0006493 name: benzophenone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A." [EC:2.3.1.151, MetaCyc:2.3.1.151-RXN] synonym: "malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.151] xref: EC:2.3.1.151 xref: GO:0047181 xref: MetaCyc:2.3.1.151-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006494 name: alcohol O-cinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate." [EC:2.3.1.152, MetaCyc:2.3.1.152-RXN] synonym: "1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity" EXACT [EC:2.3.1.152] xref: EC:2.3.1.152 xref: GO:0047182 xref: MetaCyc:2.3.1.152-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006495 name: anthocyanin 5-aromatic acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA." [EC:2.3.1.153, MetaCyc:2.3.1.153-RXN] synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.153] xref: EC:2.3.1.153 xref: GO:0047183 xref: MetaCyc:2.3.1.153-RXN is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0006496 name: 1-acylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN] synonym: "1-acyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity" EXACT [EC:2.3.1.23] synonym: "acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "lysolecithin acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "lysophosphatide acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "lysophosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23] xref: EC:2.3.1.23 xref: GO:0000507 xref: GO:0047184 xref: MetaCyc:2.3.1.23-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006497 name: N-acetylneuraminate 4-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA." [EC:2.3.1.44, MetaCyc:2.3.1.44-RXN] synonym: "acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity" EXACT [EC:2.3.1.44] synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.44] xref: EC:2.3.1.44 xref: GO:0047185 xref: MetaCyc:2.3.1.44-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0006498 name: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA." [EC:2.3.1.45, MetaCyc:2.3.1.45-RXN] synonym: "acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "glycoprotein 7(9)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "N-acetylneuraminate 7(8)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "N-acetylneuraminate 7,8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45] xref: EC:2.3.1.45 xref: GO:0047186 xref: MetaCyc:2.3.1.45-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0006499 name: deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate." [EC:2.3.1.49, MetaCyc:2.3.1.49-RXN] synonym: "deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity" EXACT [EC:2.3.1.49] synonym: "deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49] synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49] synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" EXACT [EC:2.3.1.49] xref: EC:2.3.1.49 xref: GO:0047187 xref: MetaCyc:2.3.1.49-RXN is_a: CCO:F0003141 ! S-acetyltransferase activity [Term] id: CCO:F0006500 name: aromatic-hydroxylamine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl." [EC:2.3.1.56, MetaCyc:2.3.1.56-RXN] synonym: "aromatic hydroxylamine acetyltransferase activity" EXACT [EC:2.3.1.56] synonym: "arylhydroxamate acyltransferase activity" EXACT [EC:2.3.1.56] synonym: "arylhydroxamic acid N,O-acetyltransferase activity" EXACT [EC:2.3.1.56] synonym: "arylhydroxamic acyltransferase activity" EXACT [EC:2.3.1.56] synonym: "N,O-acetyltransferase activity" EXACT [EC:2.3.1.56] synonym: "N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity" EXACT [EC:2.3.1.56] synonym: "N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity" EXACT [EC:2.3.1.56] xref: EC:2.3.1.56 xref: GO:0047188 xref: MetaCyc:2.3.1.56-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0006501 name: 2,3-diaminopropionate N-oxalyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,3-diaminopropanoate + oxalyl-CoA = N3-oxalyl-L-23-diaminopropanoate + CoA." [EC:2.3.1.58, MetaCyc:2.3.1.58-RXN] synonym: "ODAP synthase activity" EXACT [EC:2.3.1.58] synonym: "oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity" EXACT [EC:2.3.1.58] synonym: "oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity" EXACT [EC:2.3.1.58] synonym: "oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity" EXACT [EC:2.3.1.58] synonym: "oxalyldiaminopropionate synthase activity" EXACT [EC:2.3.1.58] synonym: "oxalyldiaminopropionic synthase activity" EXACT [EC:2.3.1.58] xref: EC:2.3.1.58 xref: GO:0047189 xref: MetaCyc:2.3.1.58-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006502 name: 2-acylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.62, MetaCyc:2.3.1.62-RXN] synonym: "2-acylglycerol-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.62] synonym: "2-acylglycerophosphocholine acyltransferase activity" EXACT [EC:2.3.1.62] synonym: "acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.62] xref: EC:2.3.1.62 xref: GO:0047190 xref: MetaCyc:2.3.1.62-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006503 name: 1-alkylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN] synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.63] xref: EC:2.3.1.63 xref: GO:0047191 xref: MetaCyc:2.3.1.63-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006504 name: 1-alkylglycerophosphocholine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.67, MetaCyc:2.3.1.67-RXN] synonym: "1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "1-alkyl-2-lysolecithin acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acetyl-CoA:lyso-PAF acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.67] synonym: "blood platelet-activating factor acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lyso-GPC:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lyso-platelet activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lysoPAF:acetyl CoA acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "lysopaf:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67] synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67] xref: EC:2.3.1.67 xref: GO:0047192 xref: MetaCyc:2.3.1.67-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0006505 name: CDP-acylglycerol O-arachidonoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA." [EC:2.3.1.70, MetaCyc:2.3.1.70-RXN] synonym: "arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase activity" EXACT [EC:2.3.1.70] synonym: "arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70] synonym: "CDP-acylglycerol O-arachidonyltransferase activity" EXACT [] synonym: "CDPacylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70] xref: EC:2.3.1.70 xref: GO:0047193 xref: MetaCyc:2.3.1.70-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006506 name: indoleacetylglucose-inositol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + indole-3-acetyl-beta-1-D-glucose = indole-3-acetyl-myo-inositol + beta-D-glucose." [EC:2.3.1.72, MetaCyc:2.3.1.72-RXN] synonym: "1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity" EXACT [EC:2.3.1.72] synonym: "1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity" EXACT [EC:2.3.1.72] synonym: "indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity" EXACT [EC:2.3.1.72] xref: EC:2.3.1.72 xref: GO:0047194 xref: MetaCyc:2.3.1.72-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006507 name: diacylglycerol-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol." [EC:2.3.1.73, MetaCyc:2.3.1.73-RXN] synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" EXACT [EC:2.3.1.73] synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" EXACT [EC:2.3.1.73] xref: EC:2.3.1.73 xref: GO:0047195 xref: MetaCyc:2.3.1.73-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006508 name: long-chain-alcohol O-fatty-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA." [EC:2.3.1.75, MetaCyc:2.3.1.75-RXN] synonym: "acyl-CoA:long-chain-alcohol O-acyltransferase activity" EXACT [EC:2.3.1.75] synonym: "wax synthase activity" RELATED [EC:2.3.1.75] synonym: "wax-ester synthase activity" EXACT [EC:2.3.1.75] xref: EC:2.3.1.75 xref: GO:0047196 xref: MetaCyc:2.3.1.75-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006509 name: triacylglycerol-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol." [EC:2.3.1.77, MetaCyc:2.3.1.77-RXN] synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" EXACT [EC:2.3.1.77] synonym: "triacylglycerol:sterol acyltransferase activity" EXACT [EC:2.3.1.77] xref: EC:2.3.1.77 xref: GO:0047197 xref: MetaCyc:2.3.1.77-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006510 name: cysteine-S-conjugate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an S-substituted L-cysteine + acetyl-CoA = an S-substituted N-acetyl-L-cysteine + CoA." [EC:2.3.1.80, MetaCyc:2.3.1.80-RXN] synonym: "acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity" EXACT [EC:2.3.1.80] xref: EC:2.3.1.80 xref: GO:0047198 xref: MetaCyc:2.3.1.80-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0006511 name: phosphatidylcholine-dolichol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichol + phosphatidylcholine = acyldolichol + 1-acyl-sn-glycero-3-phosphocholine." [EC:2.3.1.83, MetaCyc:2.3.1.83-RXN] synonym: "3-sn-phosphatidylcholine:dolichol O-acyltransferase activity" EXACT [EC:2.3.1.83] xref: EC:2.3.1.83 xref: GO:0047199 xref: MetaCyc:2.3.1.83-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0006512 name: tetrahydrodipicolinate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA = L-2-acetamido-6-oxoheptanedioate + CoA." [EC:2.3.1.89, MetaCyc:2.3.1.89-RXN] subset: gosubset_prok synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity" EXACT [EC:2.3.1.89] synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity" EXACT [EC:2.3.1.89] synonym: "acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity" EXACT [EC:2.3.1.89] synonym: "tetrahydrodipicolinate acetylase activity" EXACT [EC:2.3.1.89] synonym: "tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.89] xref: EC:2.3.1.89 xref: GO:0047200 xref: MetaCyc:2.3.1.89-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0006513 name: beta-glucogallin O-galloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1-O,6-O-digalloyl-beta-D-glucose + beta-D-glucose." [EC:2.3.1.90, MetaCyc:2.3.1.90-RXN] synonym: "1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity" EXACT [EC:2.3.1.90] xref: EC:2.3.1.90 xref: GO:0047201 xref: MetaCyc:2.3.1.90-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006514 name: sinapoylglucose-choline O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: choline + 1-O-sinapoyl-beta-D-glucose = O-sinapoylcholine + beta-D-glucose." [EC:2.3.1.91, MetaCyc:2.3.1.91-RXN] synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity" EXACT [EC:2.3.1.91] synonym: "sinapine synthase activity" EXACT [EC:2.3.1.91] xref: EC:2.3.1.91 xref: GO:0047202 xref: MetaCyc:2.3.1.91-RXN is_a: CCO:F0003328 ! O-sinapoyltransferase activity [Term] id: CCO:F0006515 name: 13-hydroxylupinine O-tigloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 13-hydroxylupinine + (E)-2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyl)oxylupinine + CoA." [EC:2.3.1.93, MetaCyc:2.3.1.93-RXN] synonym: "(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity" EXACT [EC:2.3.1.93] synonym: "13-hydroxylupanine acyltransferase activity" EXACT [EC:2.3.1.93] synonym: "tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity" EXACT [EC:2.3.1.93] xref: EC:2.3.1.93 xref: GO:0047203 xref: MetaCyc:2.3.1.93-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006516 name: chlorogenate-glucarate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate + chlorogenate = 2-O-caffeoylglucarate + quinate." [EC:2.3.1.98, MetaCyc:2.3.1.98-RXN] synonym: "chlorogenate:glucarate caffeoyltransferase activity" EXACT [EC:2.3.1.98] synonym: "chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.98] synonym: "chlorogenic acid:glucaric acid O-caffeoyltransferase activity" EXACT [EC:2.3.1.98] xref: EC:2.3.1.98 xref: GO:0047204 xref: MetaCyc:2.3.1.98-RXN is_a: CCO:F0008005 ! O-hydroxycinnamoyltransferase activity [Term] id: CCO:F0006517 name: quinate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA." [EC:2.3.1.99, MetaCyc:2.3.1.99-RXN] synonym: "feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.99] synonym: "hydroxycinnamoyl coenzyme A-quinate transferase activity" EXACT [EC:2.3.1.99] xref: EC:2.3.1.99 xref: GO:0047205 xref: MetaCyc:2.3.1.99-RXN is_a: CCO:F0008005 ! O-hydroxycinnamoyltransferase activity [Term] id: CCO:F0006518 name: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA." [EC:2.3.2.10, MetaCyc:2.3.2.10-RXN] synonym: "alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity" EXACT [EC:2.3.2.10] synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] xref: EC:2.3.2.10 xref: GO:0047206 xref: MetaCyc:2.3.2.10-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0006519 name: 1,2-beta-fructan 1F-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (1,2-beta-D-fructosyl)(n) + (1,2-beta-D-fructosyl)(m) = (1,2-beta-D-fructosyl)(n+1) + (1,2-beta-D-fructosyl)(m-1)." [EC:2.4.1.100, MetaCyc:2.4.1.100-RXN] synonym: "1,2-beta-D-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-D-fructan 1F-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "2,1-fructan:2,1-fructan 1-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "FFT activity" EXACT [EC:2.4.1.100] synonym: "fructan:fructan fructosyl transferase activity" EXACT [EC:2.4.1.100] xref: EC:2.4.1.100 xref: GO:0047207 xref: MetaCyc:2.4.1.100-RXN is_a: CCO:F0008006 ! fructosyltransferase activity [Term] id: CCO:F0006520 name: o-dihydroxycoumarin 7-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + UDP." [EC:2.4.1.104, MetaCyc:2.4.1.104-RXN] synonym: "UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104] synonym: "UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity" EXACT [EC:2.4.1.104] synonym: "UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104] synonym: "uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.104] xref: EC:2.4.1.104 xref: GO:0047208 xref: MetaCyc:2.4.1.104-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006521 name: coniferyl-alcohol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP." [EC:2.4.1.111, MetaCyc:2.4.1.111-RXN] synonym: "UDP-glucose coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111] synonym: "UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111] synonym: "UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111] synonym: "uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111] xref: EC:2.4.1.111 xref: GO:0047209 xref: MetaCyc:2.4.1.111-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006522 name: alpha-1,4-glucan-protein synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: protein + UDP-D-glucose = alpha-D-glucosyl-protein + UDP." [EC:2.4.1.112, MetaCyc:2.4.1.112-RXN] synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT [] xref: EC:2.4.1.112 xref: GO:0047210 xref: MetaCyc:2.4.1.112-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006523 name: alpha-1,4-glucan-protein synthase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP." [EC:2.4.1.113, MetaCyc:2.4.1.113-RXN] synonym: "1,4alpha-glucan-protein synthase (ADP-forming) activity" EXACT [] synonym: "adenosine diphosphoglucose-protein glucosyltransferase activity" EXACT [EC:2.4.1.113] synonym: "ADP-glucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113] synonym: "ADPglucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113] synonym: "ADPglucose:protein glucosyltransferase activity" EXACT [EC:2.4.1.113] xref: EC:2.4.1.113 xref: GO:0047211 xref: MetaCyc:2.4.1.113-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006524 name: 2-coumarate O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + UDP." [EC:2.4.1.114, MetaCyc:2.4.1.114-RXN] synonym: "UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114] synonym: "UDPG:o-coumaric acid O-glucosyltransferase activity" EXACT [EC:2.4.1.114] synonym: "UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114] synonym: "uridine diphosphoglucose-o-coumarate glucosyltransferase activity" EXACT [EC:2.4.1.114] xref: EC:2.4.1.114 xref: GO:0047212 xref: MetaCyc:2.4.1.114-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006525 name: anthocyanidin 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP." [EC:2.4.1.115, MetaCyc:2.4.1.115-RXN] synonym: "3-GT activity" EXACT [EC:2.4.1.115] synonym: "UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] xref: EC:2.4.1.115 xref: GO:0047213 xref: MetaCyc:2.4.1.115-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006526 name: cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP." [EC:2.4.1.116, MetaCyc:2.4.1.116-RXN] synonym: "cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116] synonym: "UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.116] synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.116] synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116] xref: EC:2.4.1.116 xref: GO:0047214 xref: MetaCyc:2.4.1.116-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006527 name: indole-3-acetate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: auxin + UDP-D-glucose = indole-3-acetyl-beta-1-D-glucose + UDP." [EC:2.4.1.121, MetaCyc:2.4.1.121-RXN] synonym: "IAA-Glu synthetase activity" EXACT [EC:2.4.1.121] synonym: "IAA-glucose synthase activity" EXACT [EC:2.4.1.121] synonym: "IAGlu synthase activity" EXACT [EC:2.4.1.121] synonym: "indol-3-ylacetylglucose synthase activity" EXACT [EC:2.4.1.121] synonym: "UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121] synonym: "UDP-glucose:indol-3-ylacetate glucosyl-transferase activity" EXACT [EC:2.4.1.121] synonym: "UDP-glucose:indol-3-ylacetate glucosyltransferase activity" EXACT [EC:2.4.1.121] synonym: "UDPG-indol-3-ylacetyl glucosyl transferase activity" EXACT [EC:2.4.1.121] synonym: "UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121] synonym: "uridine diphosphoglucose-indoleacetate glucosyltransferase activity" EXACT [EC:2.4.1.121] xref: EC:2.4.1.121 xref: GO:0047215 xref: MetaCyc:2.4.1.121-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006528 name: inositol 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP." [EC:2.4.1.123, MetaCyc:2.4.1.123-RXN] synonym: "galactinol synthase activity" EXACT [EC:2.4.1.123] synonym: "inositol 1-alpha-galactosyltransferase activity" EXACT [] synonym: "UDP-D-galactose:inositol galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "uridine diphosphogalactose-inositol galactosyltransferase activity" EXACT [EC:2.4.1.123] xref: EC:2.4.1.123 xref: GO:0047216 xref: MetaCyc:2.4.1.123-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006529 name: sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose." [EC:2.4.1.125, MetaCyc:2.4.1.125-RXN] synonym: "GTF-S" RELATED [EC:2.4.1.125] synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase" BROAD [EC:2.4.1.125] synonym: "sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.125] synonym: "sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.125] synonym: "water-soluble-glucan synthase activity" RELATED [EC:2.4.1.125] xref: EC:2.4.1.125 xref: GO:0047217 xref: MetaCyc:2.4.1.125-RXN is_a: CCO:F0006200 ! glucosyltransferase activity [Term] id: CCO:F0006530 name: hydroxycinnamate 4-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP." [EC:2.4.1.126, MetaCyc:2.4.1.126-RXN] synonym: "hydroxycinnamoyl glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "UDP-glucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126] xref: EC:2.4.1.126 xref: GO:0047218 xref: MetaCyc:2.4.1.126-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006531 name: monoterpenol beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl O-beta-D-glucoside + UDP." [EC:2.4.1.127, MetaCyc:2.4.1.127-RXN] synonym: "UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127] synonym: "UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127] synonym: "UDPglucose:monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127] synonym: "uridine diphosphoglucose-monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127] xref: EC:2.4.1.127 xref: GO:0047219 xref: MetaCyc:2.4.1.127-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006532 name: galactosylxylosylprotein 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP." [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN] synonym: "galactosyltransferase II activity" RELATED [EC:2.4.1.134] synonym: "UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134] synonym: "UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134] synonym: "uridine diphosphogalactose-galactosylxylose galactosyltransferase activity" EXACT [EC:2.4.1.134] xref: EC:2.4.1.134 xref: GO:0047220 xref: MetaCyc:2.4.1.134-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006533 name: sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol-3-phosphate + UDP-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + UDP." [EC:2.4.1.137, MetaCyc:2.4.1.137-RXN] synonym: "floridoside phosphate synthase activity" EXACT [EC:2.4.1.137] synonym: "floridoside phosphate synthetase activity" EXACT [EC:2.4.1.137] synonym: "floridoside-phosphate synthase activity" EXACT [EC:2.4.1.137] synonym: "FPS" RELATED [EC:2.4.1.137] synonym: "UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity" EXACT [EC:2.4.1.137] synonym: "UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137] synonym: "UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity" EXACT [EC:2.4.1.137] synonym: "UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137] xref: EC:2.4.1.137 xref: GO:0047221 xref: MetaCyc:2.4.1.137-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006534 name: mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP." [EC:2.4.1.138, MetaCyc:2.4.1.138-RXN] synonym: "alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138] synonym: "UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.138] synonym: "uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138] xref: EC:2.4.1.138 xref: GO:0047222 xref: MetaCyc:2.4.1.138-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006535 name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN] synonym: "elongation 3-beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146] synonym: "elongation 3beta-GalNAc-transferase activity" EXACT [EC:2.4.1.146] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.146] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.146] synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)" EXACT [EC:2.4.1.146] xref: EC:2.4.1.146 xref: GO:0047223 xref: MetaCyc:2.4.1.146-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006536 name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.147, MetaCyc:2.4.1.147-RXN] synonym: "core 3-beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147] synonym: "core 3beta-GlcNAc-transferase activity" EXACT [EC:2.4.1.147] synonym: "mucin core 3 beta3-GlcNAc-transferase activity" EXACT [EC:2.4.1.147] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.147] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.147] synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.147] xref: EC:2.4.1.147 xref: GO:0047224 xref: MetaCyc:2.4.1.147-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006537 name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.148, MetaCyc:2.4.1.148-RXN] synonym: "core 4 beta6-GalNAc-transferase activity" EXACT [EC:2.4.1.148] synonym: "core 6-beta-GalNAc-transferase B activity" RELATED [EC:2.4.1.148] synonym: "core 6beta-GalNAc-transferase B" RELATED [EC:2.4.1.148] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.148] synonym: "UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.148] synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B" RELATED [EC:2.4.1.148] xref: EC:2.4.1.148 xref: GO:0047225 xref: MetaCyc:2.4.1.148-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006538 name: indolylacetyl-myo-inositol galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-myo-inositol + UDP-galactose = 5-O-(indol-3-ylacetyl-myo-inositol)-D-galactoside + UDP." [EC:2.4.1.156, MetaCyc:2.4.1.156-RXN] synonym: "indol-3-ylacetyl-myo-inositol galactoside synthase activity" EXACT [EC:2.4.1.156] synonym: "UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156] synonym: "UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156] synonym: "uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity" EXACT [EC:2.4.1.156] xref: EC:2.4.1.156 xref: GO:0047227 xref: MetaCyc:2.4.1.156-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006539 name: 1,2-diacylglycerol 3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP." [EC:2.4.1.157, MetaCyc:2.4.1.157-RXN] subset: gosubset_prok synonym: "UDP-glucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDP-glucose:1,2-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDPglucose:diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "uridine diphosphoglucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] xref: EC:2.4.1.157 xref: GO:0047228 xref: MetaCyc:2.4.1.157-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006540 name: 13-hydroxydocosanoate 13-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP." [EC:2.4.1.158, MetaCyc:2.4.1.158-RXN] synonym: "13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158] xref: EC:2.4.1.158 xref: GO:0047229 xref: MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006541 name: flavonol-3-O-glucoside L-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP." [EC:2.4.1.159, MetaCyc:2.4.1.159-RXN] synonym: "UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.159] synonym: "UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159] synonym: "uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159] xref: EC:2.4.1.159 xref: GO:0047230 xref: MetaCyc:2.4.1.159-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006542 name: pyridoxine 5'-O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + UDP." [EC:2.4.1.160, MetaCyc:2.4.1.160-RXN] synonym: "UDP-glucose-pyridoxine glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160] xref: EC:2.4.1.160 xref: GO:0047231 xref: MetaCyc:2.4.1.160-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006543 name: galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP." [EC:2.4.1.164, MetaCyc:2.4.1.164-RXN] synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.164] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.164] xref: EC:2.4.1.164 xref: GO:0047232 xref: MetaCyc:2.4.1.164-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006544 name: N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.165, MetaCyc:2.4.1.165-RXN] synonym: "UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165] synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165] xref: EC:2.4.1.165 xref: GO:0047233 xref: MetaCyc:2.4.1.165-RXN is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0006545 name: raffinose-raffinose alpha-galactotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose." [EC:2.4.1.166, MetaCyc:2.4.1.166-RXN] subset: gosubset_prok synonym: "raffinose (raffinose donor) galactosyltransferase activity" EXACT [EC:2.4.1.166] synonym: "raffinose-raffinose a-galactosyltransferase activity" EXACT [] synonym: "raffinose-raffinose alpha-galactosyltransferase activity" EXACT [] synonym: "raffinose:raffinose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.166] synonym: "raffinose:raffinose alpha-galactosyltransferase activity" EXACT [EC:2.4.1.166] xref: EC:2.4.1.166 xref: GO:0047234 xref: MetaCyc:2.4.1.166-RXN is_a: CCO:F0001853 ! galactosyltransferase activity [Term] id: CCO:F0006546 name: sucrose 6F-alpha-galactotransferase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP." [EC:2.4.1.167, MetaCyc:2.4.1.167-RXN] synonym: "sucrose 6(F)-alpha-galactosyltransferase activity" EXACT [] synonym: "sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] xref: EC:2.4.1.167 xref: GO:0047235 xref: MetaCyc:2.4.1.167-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006547 name: methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CH(3)-N(O)=N-CH(2)OH + UDP-D-glucose = cycasin + UDP." [EC:2.4.1.171, MetaCyc:2.4.1.171-RXN] synonym: "cycasin synthase activity" EXACT [EC:2.4.1.171] synonym: "methyl-ONN-azoxymethanol glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.171] synonym: "UDPglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171] synonym: "uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171] xref: EC:2.4.1.171 xref: GO:0047236 xref: MetaCyc:2.4.1.171-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006548 name: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP." [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN] synonym: "glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "N-acetylgalactosaminyltransferase I activity" EXACT [] synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.174] synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I" RELATED [EC:2.4.1.174] synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" EXACT [EC:2.4.1.174] xref: EC:2.4.1.174 xref: GO:0047237 xref: MetaCyc:2.4.1.174-RXN is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0006549 name: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN] synonym: "chondroitin synthase activity" EXACT [EC:2.4.1.175] synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "N-acetylgalactosaminyltransferase II activity" EXACT [] synonym: "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175] synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175] synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity" EXACT [EC:2.4.1.175] xref: EC:2.4.1.175 xref: GO:0047238 xref: MetaCyc:2.4.1.175-RXN is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0006550 name: hydroxymandelonitrile glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = taxiphyllin + UDP." [EC:2.4.1.178, MetaCyc:2.4.1.178-RXN] synonym: "cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.178] synonym: "UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178] synonym: "UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178] xref: EC:2.4.1.178 xref: GO:0047239 xref: MetaCyc:2.4.1.178-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006551 name: lactosylceramide beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-1,4-beta-D-glucosyl-R + UDP-galactose = D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R + UDP." [EC:2.4.1.179, MetaCyc:2.4.1.179-RXN] synonym: "UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179] synonym: "UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179] synonym: "uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity" EXACT [EC:2.4.1.179] xref: EC:2.4.1.179 xref: GO:0047240 xref: MetaCyc:2.4.1.179-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity is_a: CCO:F0007345 ! beta-1,3-galactosyltransferase activity [Term] id: CCO:F0006552 name: lipopolysaccharide N-acetylmannosaminouronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP." [EC:2.4.1.180, MetaCyc:2.4.1.180-RXN] synonym: "LPS N-acetylmannosaminouronosyltransferase activity" EXACT [] synonym: "ManNAcA transferase activity" EXACT [EC:2.4.1.180] synonym: "UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity" EXACT [EC:2.4.1.180] synonym: "uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity" EXACT [EC:2.4.1.180] xref: EC:2.4.1.180 xref: GO:0047241 xref: MetaCyc:2.4.1.180-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006553 name: hydroxyanthraquinone glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP." [EC:2.4.1.181, MetaCyc:2.4.1.181-RXN] synonym: "anthraquinone-specific glucosyltransferase activity" EXACT [EC:2.4.1.181] synonym: "UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181] synonym: "UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181] synonym: "uridine diphosphoglucose-anthraquinone glucosyltransferase activity" EXACT [EC:2.4.1.181] xref: EC:2.4.1.181 xref: GO:0047242 xref: MetaCyc:2.4.1.181-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006554 name: flavanone 7-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP." [EC:2.4.1.185, MetaCyc:2.4.1.185-RXN] synonym: "hesperetin 7-O-glucosyl-transferase activity" EXACT [EC:2.4.1.185] synonym: "naringenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185] synonym: "UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185] synonym: "UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185] synonym: "uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185] xref: EC:2.4.1.185 xref: GO:0047243 xref: MetaCyc:2.4.1.185-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006555 name: N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.187, MetaCyc:2.4.1.187-RXN] subset: gosubset_prok synonym: "N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] synonym: "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] synonym: "UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] synonym: "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] xref: EC:2.4.1.187 xref: GO:0047244 xref: MetaCyc:TEICHOICSYN2-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006556 name: N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.188, MetaCyc:2.4.1.188-RXN] synonym: "UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188] synonym: "UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188] synonym: "UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188] synonym: "uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188] xref: EC:2.4.1.188 xref: GO:0047245 xref: MetaCyc:2.4.1.188-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006557 name: luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolin 7-O-glucuronide + UDP-D-glucuronate = luteolin 7-O-beta-D-diglucuronide + UDP." [EC:2.4.1.190, MetaCyc:2.4.1.190-RXN] synonym: "LMT activity" RELATED [EC:2.4.1.190] synonym: "luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] synonym: "UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] synonym: "UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.190] xref: EC:2.4.1.190 xref: GO:0047246 xref: MetaCyc:2.4.1.190-RXN is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0006558 name: luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucuronide + UDP-D-glucuronate = luteolin 7-O-[beta-D-glucuronosyl-(1,2)-beta-D-glucuronide]-4'-O-beta-D-glucuronide + UDP." [EC:2.4.1.191, MetaCyc:2.4.1.191-RXN] synonym: "LDT" RELATED [EC:2.4.1.191] synonym: "UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] synonym: "UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] synonym: "UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity" EXACT [EC:2.4.1.191] synonym: "UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] synonym: "uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.191] xref: EC:2.4.1.191 xref: GO:0047247 xref: MetaCyc:2.4.1.191-RXN is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0006559 name: nuatigenin 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (20S,22S,25S)-22,25-epoxyfurost-5-ene-3-beta,26-diol + UDP-D-glucose = (20S,22S,25S)-22,25-epoxyfurost-5-ene-3-beta,26-diol 3-O-beta-D-glucoside + UDP." [EC:2.4.1.192, MetaCyc:2.4.1.192-RXN] synonym: "nuatigenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.192] synonym: "UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192] synonym: "UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192] synonym: "uridine diphosphoglucose-nuatigenin glucosyltransferase activity" EXACT [EC:2.4.1.192] xref: EC:2.4.1.192 xref: GO:0047248 xref: MetaCyc:2.4.1.192-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006560 name: sarsapogenin 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (25S)-5-beta-spirostan-3-beta-ol + UDP-D-glucose = (25S)-5-beta-spirostan-3-beta-ol 3-O-beta-D-glucoside + UDP." [EC:2.4.1.193, MetaCyc:2.4.1.193-RXN] synonym: "sarsapogenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.193] synonym: "UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193] synonym: "UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193] synonym: "uridine diphosphoglucose-sarsapogenin glucosyltransferase activity" EXACT [EC:2.4.1.193] xref: EC:2.4.1.193 xref: GO:0047249 xref: MetaCyc:2.4.1.193-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006561 name: 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: p-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + UDP." [EC:2.4.1.194, MetaCyc:2.4.1.194-RXN] synonym: "HBA glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "p-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "PHB glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "PHB-O-glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194] xref: EC:2.4.1.194 xref: GO:0047250 xref: MetaCyc:2.4.1.194-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006562 name: thiohydroximate beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP." [EC:2.4.1.195, MetaCyc:2.4.1.195-RXN] synonym: "desulfoglucosinolate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "N-hydroxythioamide S-beta-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "thiohydroximate S-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "UDPG:thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "uridine diphosphoglucose-thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] xref: EC:2.4.1.195 xref: GO:0047251 xref: MetaCyc:2.4.1.195-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006563 name: beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,6-alpha-D-mannosyloligodaccharide + beta-D-mannosylphosphodecaprenol = 1,6-alpha-D-mannosyl-1,6-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate." [EC:2.4.1.199, MetaCyc:2.4.1.199-RXN] synonym: "beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.199] synonym: "mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.199] xref: EC:2.4.1.199 xref: GO:0047252 xref: MetaCyc:2.4.1.199-RXN is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0006564 name: alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP." [EC:2.4.1.201, MetaCyc:2.4.1.201-RXN] synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity" EXACT [] synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.201] synonym: "N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201] synonym: "UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.201] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI" RELATED [EC:2.4.1.201] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201] xref: EC:2.4.1.201 xref: GO:0047253 xref: MetaCyc:2.4.1.201-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006565 name: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP." [EC:2.4.1.202, MetaCyc:2.4.1.202-RXN] synonym: "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202] synonym: "UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202] synonym: "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity" EXACT [EC:2.4.1.202] xref: EC:2.4.1.202 xref: GO:0047254 xref: MetaCyc:2.4.1.202-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006566 name: galactogen 6-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP." [EC:2.4.1.205, MetaCyc:2.4.1.205-RXN] synonym: "1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "beta-(1-6)-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "galactogen 6beta-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "uridine diphosphogalactose-galactogen galactosyltransferase activity" EXACT [EC:2.4.1.205] xref: EC:2.4.1.205 xref: GO:0047255 xref: MetaCyc:2.4.1.205-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006567 name: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.206, MetaCyc:2.4.1.206-RXN] synonym: "beta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] synonym: "LA2 synthase activity" EXACT [EC:2.4.1.206] synonym: "lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] synonym: "uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] xref: EC:2.4.1.206 xref: GO:0047256 xref: MetaCyc:2.4.1.206-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006568 name: diglucosyl diacylglycerol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)sn-glycerol." [EC:2.4.1.208, MetaCyc:2.4.1.208-RXN] synonym: "DGlcDAG synthase activity" EXACT [EC:2.4.1.208] synonym: "diglucosyl diacylglycerol (DGlcDAG) synthase activity" EXACT [] synonym: "MGlcDAG (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] xref: EC:2.4.1.208 xref: GO:0047257 xref: MetaCyc:2.4.1.208-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006569 name: sphingosine beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine + UDP-galactose = psychosine + UDP." [EC:2.4.1.23, MetaCyc:2.4.1.23-RXN] synonym: "galactosyl-sphingosine transferase activity" EXACT [EC:2.4.1.23] synonym: "psychosine-UDP galactosyltransferase activity" EXACT [EC:2.4.1.23] synonym: "psychosine-uridine diphosphate galactosyltransferase activity" EXACT [EC:2.4.1.23] synonym: "UDP-galactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23] synonym: "UDPgalactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23] synonym: "UDPgalactose:sphingosine O-galactosyl transferase activity" EXACT [EC:2.4.1.23] synonym: "uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity" EXACT [EC:2.4.1.23] xref: EC:2.4.1.23 xref: GO:0047258 xref: MetaCyc:2.4.1.23-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006570 name: glucomannan 4-beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP." [EC:2.4.1.32, MetaCyc:2.4.1.32-RXN] synonym: "GDP-man-beta-mannan manosyltransferase activity" EXACT [EC:2.4.1.32] synonym: "GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity" EXACT [] synonym: "glucomannan 4-b-mannosyltransferase activity" EXACT [] synonym: "glucomannan-synthase activity" EXACT [] xref: EC:2.4.1.32 xref: GO:0047259 xref: MetaCyc:2.4.1.32-RXN is_a: CCO:F0004117 ! beta-1,4-mannosyltransferase activity [Term] id: CCO:F0006571 name: alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP." [EC:2.4.1.36, MetaCyc:2.4.1.36-RXN] synonym: "GDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "GDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "trehalose phosphate synthase (GDP-forming) activity" EXACT [EC:2.4.1.36] xref: EC:2.4.1.36 xref: GO:0047260 xref: MetaCyc:2.4.1.36-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006572 name: steroid N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-alpha 3-D-glucuronoside + UDP-N-acetyl-D-glucosamine = 17-alpha-(N-acetyl-D-glucosaminyl)estradiol 3-D-glucuronoside + UDP." [EC:2.4.1.39, MetaCyc:2.4.1.39-RXN] synonym: "hydroxy steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] synonym: "steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] synonym: "UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] synonym: "uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] xref: EC:2.4.1.39 xref: GO:0047261 xref: MetaCyc:2.4.1.39-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006573 name: polygalacturonate 4-alpha-galacturonosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP." [EC:2.4.1.43, MetaCyc:2.4.1.43-RXN] synonym: "UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] xref: EC:2.4.1.43 xref: GO:0047262 xref: GO:0050375 xref: MetaCyc:2.4.1.43-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006574 name: N-acylsphingosine galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP." [EC:2.4.1.47, MetaCyc:2.4.1.47-RXN] synonym: "UDP galactose-N-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47] synonym: "UDP-galactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47] synonym: "UDPgalactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47] synonym: "uridine diphosphogalactose-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47] xref: EC:2.4.1.47 xref: GO:0047263 xref: MetaCyc:2.4.1.47-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006575 name: heteroglycan alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: heteroglycan + GDP-mannose = 1,2(or 1,3)-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:2.4.1.48-RXN] synonym: "GDP mannose alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] xref: EC:2.4.1.48 xref: GO:0047264 xref: MetaCyc:2.4.1.48-RXN is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0006576 name: poly(glycerol-phosphate) alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP." [EC:2.4.1.52, MetaCyc:2.4.1.52-RXN] subset: gosubset_prok synonym: "UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52] synonym: "UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52] synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52] synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52] xref: EC:2.4.1.52 xref: GO:0047265 xref: MetaCyc:2.4.1.52-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006577 name: poly(ribitol-phosphate) beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP." [EC:2.4.1.53, MetaCyc:2.4.1.53-RXN] synonym: "UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53] synonym: "UDP-D-glucose polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53] synonym: "UDP-D-glucose:polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53] synonym: "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53] synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53] synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53] xref: EC:2.4.1.53 xref: GO:0047266 xref: MetaCyc:2.4.1.53-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006578 name: undecaprenyl-phosphate mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: undecaprenyl phosphate + GDP-mannose = D-mannosyl-1-phosphoundecaprenol + GDP." [EC:2.4.1.54, MetaCyc:2.4.1.54-RXN] synonym: "GDP mannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54] synonym: "GDP-D-mannose:lipid phosphate transmannosylase activity" EXACT [EC:2.4.1.54] synonym: "GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity" EXACT [EC:2.4.1.54] synonym: "guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54] xref: EC:2.4.1.54 xref: GO:0047267 xref: MetaCyc:2.4.1.54-RXN is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0006579 name: galactinol-raffinose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol." [EC:2.4.1.67, MetaCyc:2.4.1.67-RXN] synonym: "alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity" EXACT [EC:2.4.1.67] synonym: "stachyose synthetase activity" EXACT [EC:2.4.1.67] xref: EC:2.4.1.67 xref: GO:0047268 xref: MetaCyc:2.4.1.67-RXN is_a: CCO:F0001853 ! galactosyltransferase activity [Term] id: CCO:F0006580 name: poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP." [EC:2.4.1.70, MetaCyc:2.4.1.70-RXN] synonym: "UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70] synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.70] synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70] xref: EC:2.4.1.70 xref: GO:0047269 xref: MetaCyc:2.4.1.70-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0006581 name: lipopolysaccharide glucosyltransferase II activity namespace: molecular_function def: "Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP." [EC:2.4.1.73, MetaCyc:2.4.1.73-RXN] synonym: "LPS glucosyltransferase II activity" EXACT [] synonym: "UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73] synonym: "UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73] synonym: "uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.73] xref: EC:2.4.1.73 xref: GO:0047270 xref: MetaCyc:2.4.1.73-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006582 name: glycosaminoglycan galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP." [EC:2.4.1.74, MetaCyc:2.4.1.74-RXN] synonym: "UDP-galactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74] synonym: "UDPgalactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74] synonym: "uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.74] xref: EC:2.4.1.74 xref: GO:0047271 xref: MetaCyc:2.4.1.74-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006583 name: phosphopolyprenol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP." [EC:2.4.1.78, MetaCyc:2.4.1.78-RXN] synonym: "UDP-glucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78] synonym: "UDPglucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78] synonym: "UDPglucose:polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78] synonym: "uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78] xref: EC:2.4.1.78 xref: GO:0047272 xref: MetaCyc:2.4.1.78-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006584 name: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide." [EC:2.4.1.79, MetaCyc:2.4.1.79-RXN] synonym: "beta-3GalNAc-T1 activity" EXACT [EC:2.4.1.79] synonym: "beta3GalNAc-T1" RELATED [EC:2.4.1.79] synonym: "galactosylgalactosylglucosylceramide beta-D- activity" EXACT [EC:2.4.1.79] synonym: "globoside synthase activity" EXACT [EC:2.4.1.79] synonym: "globoside synthetase activity" EXACT [EC:2.4.1.79] synonym: "globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] xref: EC:2.4.1.79 xref: GO:0047226 xref: GO:0047273 xref: MetaCyc:2.4.1.79-RXN is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0006585 name: galactinol-sucrose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol." [EC:2.4.1.82, MetaCyc:2.4.1.82-RXN] synonym: "1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82] synonym: "alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82] synonym: "galactinol:sucrose 6-galactosyl transferase activity" EXACT [] synonym: "galactosyltransferase, galactinol-sucrose" EXACT [] synonym: "raffinose synthase activity" EXACT [] xref: EC:2.4.1.82 xref: GO:0047274 xref: MetaCyc:2.4.1.82-RXN is_a: CCO:F0001853 ! galactosyltransferase activity [Term] id: CCO:F0006586 name: glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.86, MetaCyc:2.4.1.86-RXN] synonym: "GalT-4" RELATED [EC:2.4.1.86] synonym: "paragloboside synthase activity" EXACT [EC:2.4.1.86] synonym: "UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86] synonym: "UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86] synonym: "uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.86] xref: EC:2.4.1.86 xref: GO:0047275 xref: MetaCyc:2.4.1.86-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006587 name: N-acetyllactosaminide 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP." [EC:2.4.1.87, MetaCyc:2.4.1.87-RXN] synonym: "alpha-galactosyltransferase activity" RELATED [EC:2.4.1.87] synonym: "beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [] synonym: "glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "N-acetyllactosaminide alpha-1,3-galactosyltransferase activity" EXACT [] synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87] xref: EC:2.4.1.87 xref: GO:0003946 xref: GO:0047276 xref: MetaCyc:2.4.1.151-RXN xref: MetaCyc:2.4.1.87-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006588 name: globoside alpha-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.88, MetaCyc:2.4.1.88-RXN] synonym: "Forssman synthase activity" RELATED [EC:2.4.1.88] synonym: "forssman synthase activity" EXACT [EC:2.4.1.88] synonym: "globoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88] synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.88] synonym: "uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88] xref: EC:2.4.1.88 xref: GO:0047277 xref: MetaCyc:2.4.1.88-RXN is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0006589 name: bilirubin-glucuronoside glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin-bisglucuronoside + bilirubin." [EC:2.4.1.95, MetaCyc:2.4.1.95-RXN] synonym: "bilirubin glucuronoside glucuronosyltransferase activity" EXACT [EC:2.4.1.95] synonym: "bilirubin monoglucuronide transglucuronidase activity" EXACT [EC:2.4.1.95] synonym: "bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity" EXACT [EC:2.4.1.95] xref: EC:2.4.1.95 xref: GO:0047278 xref: MetaCyc:2.4.1.95-RXN is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0006590 name: sn-glycerol-3-phosphate 1-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol-3-phosphate + UDP-galactose = alpha-D-galactosyl-(1,1')-sn-glycerol 3-phosphate + UDP." [EC:2.4.1.96, MetaCyc:2.4.1.96-RXN] synonym: "glycerol 3-phosphate 1alpha-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "isofloridoside-phosphate synthase activity" EXACT [EC:2.4.1.96] synonym: "UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity" EXACT [EC:2.4.1.96] synonym: "UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity" EXACT [EC:2.4.1.96] xref: EC:2.4.1.96 xref: GO:0047279 xref: MetaCyc:2.4.1.96-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0006591 name: nicotinamide phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide." [EC:2.4.2.12, MetaCyc:2.4.2.12-RXN] synonym: "nicotinamide mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.12] synonym: "nicotinamide mononucleotide synthetase activity" EXACT [EC:2.4.2.12] synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.12] synonym: "NMN diphosphorylase activity" EXACT [EC:2.4.2.12] synonym: "NMN pyrophosphorylase activity" EXACT [EC:2.4.2.12] synonym: "NMN synthetase activity" EXACT [EC:2.4.2.12] xref: EC:2.4.2.12 xref: GO:0047280 xref: MetaCyc:2.4.2.12-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0006592 name: dioxotetrahydropyrimidine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine." [EC:2.4.2.20, MetaCyc:2.4.2.20-RXN] synonym: "2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine phosphoribosyl transferase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20] xref: EC:2.4.2.20 xref: GO:0047281 xref: MetaCyc:2.4.2.20-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0006593 name: dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: streptidine 6-phosphate + dTDP-L-dihydrostreptose = O-1,4-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP." [EC:2.4.2.27, MetaCyc:2.4.2.27-RXN] subset: gosubset_prok synonym: "dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] synonym: "dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] synonym: "thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] xref: EC:2.4.2.27 xref: GO:0047282 xref: MetaCyc:2.4.2.27-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0006594 name: dolichyl-phosphate D-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP." [EC:2.4.2.32, MetaCyc:2.4.2.32-RXN] synonym: "UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity" EXACT [EC:2.4.2.32] xref: EC:2.4.2.32 xref: GO:0047283 xref: MetaCyc:2.4.2.32-RXN is_a: CCO:F0005581 ! UDP-xylosyltransferase activity [Term] id: CCO:F0006595 name: dolichyl-xylosyl-phosphate-protein xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein." [EC:2.4.2.33, MetaCyc:2.4.2.33-RXN] synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" EXACT [EC:2.4.2.33] xref: EC:2.4.2.33 xref: GO:0047284 xref: MetaCyc:2.4.2.33-RXN is_a: CCO:F0005645 ! xylosyltransferase activity [Term] id: CCO:F0006596 name: flavonol-3-O-glycoside xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP." [EC:2.4.2.35, MetaCyc:2.4.2.35-RXN] synonym: "UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.35] xref: EC:2.4.2.35 xref: GO:0047285 xref: MetaCyc:2.4.2.35-RXN is_a: CCO:F0005581 ! UDP-xylosyltransferase activity [Term] id: CCO:F0006597 name: NAD+-diphthamide ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide." [EC:2.4.2.36, MetaCyc:2.4.2.36-RXN] subset: gosubset_prok synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.36] synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.36] synonym: "NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.36] synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.36 xref: GO:0047286 xref: MetaCyc:2.4.2.36-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0006598 name: lactosylceramide alpha-2,6-N-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP." [EC:2.4.99.11, MetaCyc:2.4.99.11-RXN] synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.11] synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.11] synonym: "CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11] synonym: "CMP-sialic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11] synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.11] xref: EC:2.4.99.11 xref: GO:0047287 xref: MetaCyc:2.4.99.11-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0006599 name: monosialoganglioside sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP." [EC:2.4.99.2, MetaCyc:2.4.99.2-RXN] synonym: "CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.2] xref: EC:2.4.99.2 xref: GO:0047288 xref: MetaCyc:2.4.99.2-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0006600 name: galactosyldiacylglycerol alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetylneuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP." [EC:2.4.99.5, MetaCyc:2.4.99.5-RXN] synonym: "CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.5] xref: EC:2.4.99.5 xref: GO:0047289 xref: MetaCyc:2.4.99.5-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0006602 name: lactosylceramide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3." [EC:2.4.99.9, MetaCyc:2.4.99.9-RXN] synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.9] synonym: "CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.9] synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.9] synonym: "CMP-sialic acid:lactosylceramide-sialyltransferase activity" EXACT [EC:2.4.99.9] synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity" EXACT [EC:2.4.99.9] synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.9] synonym: "ganglioside GM3 synthase activity" EXACT [EC:2.4.99.9] synonym: "ganglioside GM3 synthetase activity" EXACT [EC:2.4.99.9] synonym: "GM3 synthase activity" EXACT [EC:2.4.99.9] synonym: "GM3 synthetase activity" EXACT [EC:2.4.99.9] synonym: "SAT 1" RELATED [EC:2.4.99.9] xref: EC:2.4.99.9 xref: GO:0047291 xref: MetaCyc:2.4.99.9-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0006603 name: trihydroxypterocarpan dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + pyrophosphate." [EC:2.5.1.36, MetaCyc:2.5.1.36-RXN] synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36] synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity" EXACT [EC:2.5.1.36] synonym: "dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36] synonym: "dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity" EXACT [EC:2.5.1.36] xref: EC:2.5.1.36 xref: GO:0047292 xref: MetaCyc:2.5.1.36-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0006604 name: 4-hydroxybenzoate nonaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + pyrophosphate." [EC:2.5.1.39, MetaCyc:2.5.1.39-RXN] synonym: "4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39] synonym: "nonaprenyl-4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoate dimethylallyltransferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoate polyprenyltransferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoic acid-polyprenyl transferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoic-polyprenyl transferase activity" EXACT [EC:2.5.1.39] synonym: "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity" EXACT [EC:2.5.1.39] xref: EC:2.5.1.39 xref: GO:0047293 xref: MetaCyc:2.5.1.39-RXN is_a: CCO:F0000268 ! polyprenyltransferase activity [Term] id: CCO:F0006605 name: phosphoglycerol geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glyceryl phosphate + geranylgeranyl-PP = sn-3-O-(geranylgeranyl)glyceryl 1-phosphate + diphosphate." [EC:2.5.1.41, MetaCyc:2.5.1.41-RXN] synonym: "geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41] synonym: "geranylgeranyl-transferase activity" EXACT [EC:2.5.1.41] synonym: "glycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41] xref: EC:2.5.1.41 xref: GO:0047294 xref: MetaCyc:2.5.1.41-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0006606 name: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + geranylgeranyl-PP = 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.42, MetaCyc:2.5.1.42-RXN] synonym: "geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42] synonym: "geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42] synonym: "geranylgeranyltransferase II" RELATED [EC:2.5.1.42] xref: EC:2.5.1.42 xref: GO:0047295 xref: MetaCyc:2.5.1.42-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0006607 name: homospermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2.5.1.44, MetaCyc:2.5.1.44-RXN] subset: gosubset_prok synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" EXACT [EC:2.5.1.44] xref: EC:2.5.1.44 xref: GO:0047296 xref: MetaCyc:2.5.1.44-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0006608 name: asparagine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate." [EC:2.6.1.14, MetaCyc:2.6.1.14-RXN] synonym: "asparagine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14] synonym: "asparagine-keto acid aminotransferase activity" EXACT [EC:2.6.1.14] synonym: "asparagine-oxo-acid aminotransferase activity" EXACT [] synonym: "L-asparagine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14] xref: EC:2.6.1.14 xref: GO:0047297 xref: MetaCyc:2.6.1.14-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006610 name: tryptophan-phenylpyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: phenylpyruvate + L-tryptophan = L-phenylalanine + indolepyruvate." [EC:2.6.1.28, MetaCyc:2.6.1.28-RXN] synonym: "L-tryptophan-alpha-ketoisocaproate aminotransferase activity" EXACT [EC:2.6.1.28] synonym: "L-tryptophan:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28] synonym: "tryptophan--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28] synonym: "tryptophan-phenylpyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.28 xref: GO:0047299 xref: MetaCyc:2.6.1.28-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006611 name: pyridoxamine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + pyridoxamine = L-alanine + pyridoxal." [EC:2.6.1.30, MetaCyc:2.6.1.30-RXN] synonym: "pyridoxamine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.30] synonym: "pyridoxamine-pyruvate aminotransferase activity" EXACT [] synonym: "pyridoxamine-pyruvic transaminase" BROAD [EC:2.6.1.30] synonym: "pyridoxamine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.30] synonym: "pyridoxamineu-pyruvic transaminase activity" EXACT [EC:2.6.1.30] xref: EC:2.6.1.30 xref: GO:0047300 xref: MetaCyc:2.6.1.30-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006612 name: valine-3-methyl-2-oxovalerate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-3-methyl-valerate + L-valine = L-iso-leucine + 2-keto-isovalerate." [EC:2.6.1.32, MetaCyc:2.6.1.32-RXN] synonym: "L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine--3-methyl-2-oxovalerate aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine--isoleucine aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine--isoleucine transaminase activity" EXACT [EC:2.6.1.32] synonym: "valine-2-keto-methylvalerate aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine-3-methyl-2-oxovalerate aminotransferase activity" EXACT [] xref: EC:2.6.1.32 xref: GO:0047301 xref: MetaCyc:2.6.1.32-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006613 name: UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose." [EC:2.6.1.34, MetaCyc:2.6.1.34-RXN] synonym: "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.34] synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [] synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity" EXACT [] synonym: "uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.34] xref: EC:2.6.1.34 xref: GO:0047302 xref: MetaCyc:2.6.1.34-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006614 name: glycine-oxaloacetate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetic acid + L-glycine = L-aspartate + glyoxylate." [EC:2.6.1.35, MetaCyc:2.6.1.35-RXN] synonym: "glycine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35] synonym: "glycine-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.35] synonym: "glycine-oxaloacetate aminotransferase activity" EXACT [] synonym: "glycine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35] xref: EC:2.6.1.35 xref: GO:0047303 xref: MetaCyc:2.6.1.35-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006615 name: 2-aminoethylphosphonate-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + (2-aminoethyl)phosphonate = L-alanine + phosphonoacetaldehyde." [EC:2.6.1.37, MetaCyc:2.6.1.37-RXN] subset: gosubset_prok synonym: "(2-aminoethyl)phosphonate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonate transaminase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonic acid aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "2-aminoethylphosphonate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "2-aminoethylphosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "2-aminoethylphosphonate-pyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.37 xref: GO:0047304 xref: MetaCyc:2.6.1.37-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006617 name: D-methionine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + D-methionine = L-alanine + 2-keto-4-methylthiobutyrate." [EC:2.6.1.41, MetaCyc:2.6.1.41-RXN] synonym: "D-methionine aminotransferase activity" EXACT [EC:2.6.1.41] synonym: "D-methionine transaminase activity" EXACT [EC:2.6.1.41] synonym: "D-methionine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.41] synonym: "D-methionine-pyruvate aminotransferase activity" EXACT [] synonym: "D-methionine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.41] xref: EC:2.6.1.41 xref: GO:0047306 xref: MetaCyc:2.6.1.41-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006618 name: diaminobutyrate-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + L-2,4-diaminobutanoate = L-aspartate-semialdehyde + L-alanine." [EC:2.6.1.46, MetaCyc:2.6.1.46-RXN] subset: gosubset_prok synonym: "diaminobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.46] synonym: "diaminobutyrate-pyruvate aminotransferase activity" EXACT [] synonym: "L-2,4-diaminobutanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.46] synonym: "L-diaminobutyric acid transaminase activity" EXACT [EC:2.6.1.46] xref: EC:2.6.1.46 xref: GO:0047307 xref: MetaCyc:2.6.1.46-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006619 name: alanine-oxomalonate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: oxomalonate + L-alanine = aminomalonate + pyruvate." [EC:2.6.1.47, MetaCyc:2.6.1.47-RXN] synonym: "alanine--oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47] synonym: "alanine-ketomalonate (mesoxalate) transaminase activity" EXACT [EC:2.6.1.47] synonym: "alanine-oxomalonate aminotransferase activity" EXACT [] synonym: "L-alanine-ketomalonate transaminase activity" EXACT [EC:2.6.1.47] synonym: "L-alanine:oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47] xref: EC:2.6.1.47 xref: GO:0047308 xref: MetaCyc:2.6.1.47-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006620 name: dihydroxyphenylalanine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-dihydroxy-phenylalanine = L-glutamate + 3,4-dihydroxyphenylpyruvate." [EC:2.6.1.49, MetaCyc:2.6.1.49-RXN] synonym: "3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.49] synonym: "aspartate-DOPP transaminase (ADT)" EXACT [EC:2.6.1.49] synonym: "dihydroxyphenylalanine aminotransferase activity" EXACT [] synonym: "dopa aminotransferase activity" EXACT [EC:2.6.1.49] synonym: "DOPA aminotransferase activity" EXACT [EC:2.6.1.49] synonym: "dopa transaminase activity" EXACT [EC:2.6.1.49] synonym: "glutamate-DOPP transaminase (GDT)" EXACT [EC:2.6.1.49] synonym: "L-dopa transaminase activity" EXACT [EC:2.6.1.49] synonym: "phenylalanine-DOPP transaminase (PDT)" EXACT [EC:2.6.1.49] xref: EC:2.6.1.49 xref: GO:0047309 xref: MetaCyc:2.6.1.49-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006621 name: glutamine-scyllo-inositol transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-myo-inositol + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-keto-glutaramate." [EC:2.6.1.50, MetaCyc:2.6.1.50-RXN] subset: gosubset_prok synonym: "glutamine scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50] synonym: "glutamine--scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50] synonym: "glutamine--scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50] synonym: "glutamine-scyllo-inosose aminotransferase activity" EXACT [] synonym: "glutamine-scyllo-inosose transaminase activity" EXACT [] synonym: "L-glutamine-keto-scyllo-inositol aminotransferase activity" EXACT [EC:2.6.1.50] synonym: "L-glutamine-scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50] synonym: "L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity" EXACT [EC:2.6.1.50] xref: EC:2.6.1.50 xref: GO:0047310 xref: MetaCyc:2.6.1.50-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006622 name: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol = L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol." [EC:2.6.1.56, MetaCyc:2.6.1.56-RXN] synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity" EXACT [] synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity" EXACT [EC:2.6.1.56] synonym: "guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity" EXACT [EC:2.6.1.56] synonym: "L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity" EXACT [EC:2.6.1.56] xref: EC:2.6.1.56 xref: GO:0047311 xref: MetaCyc:2.6.1.56-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006623 name: phenylalanine(histidine) transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine." [EC:2.6.1.58, MetaCyc:2.6.1.58-RXN] synonym: "histidine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.58] synonym: "L-phenylalanine(L-histidine):pyruvate aminotransferase activity" EXACT [EC:2.6.1.58] synonym: "L-phenylalanine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.58] synonym: "phenylalanine (histidine) aminotransferase activity" EXACT [EC:2.6.1.58] synonym: "phenylalanine(histidine) aminotransferase activity" EXACT [] synonym: "phenylalanine(histidine):pyruvate aminotransferase activity" EXACT [EC:2.6.1.58] xref: EC:2.6.1.58 xref: GO:0047312 xref: MetaCyc:2.6.1.58-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006624 name: aromatic-amino-acid-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid." [EC:2.6.1.60, MetaCyc:2.6.1.60-RXN] synonym: "aromatic-amino-acid--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60] synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60] xref: EC:2.6.1.60 xref: GO:0047313 xref: MetaCyc:2.6.1.60-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006625 name: kynurenine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + kynurenine = L-glycine + 4-(2-aminophenyl)-2,4-dioxobutanoate." [EC:2.6.1.63, MetaCyc:2.6.1.63-RXN] synonym: "kynurenine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.63] synonym: "kynurenine-glyoxylate aminotransferase activity" EXACT [] synonym: "L-kynurenine:glyoxylate aminotransferase (cyclizing)" EXACT [EC:2.6.1.63] xref: EC:2.6.1.63 xref: GO:0047315 xref: MetaCyc:2.6.1.63-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006626 name: glutamine-phenylpyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: phenylpyruvate + L-glutamine = L-phenylalanine + 2-keto-glutaramate." [EC:2.6.1.64, MetaCyc:2.6.1.64-RXN] synonym: "glutamine transaminase K activity" RELATED [EC:2.6.1.64] synonym: "glutamine--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64] synonym: "glutamine-phenylpyruvate aminotransferase activity" EXACT [] synonym: "L-glutamine:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64] xref: EC:2.6.1.64 xref: GO:0047316 xref: MetaCyc:2.6.1.64-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006627 name: N6-acetyl-beta-lysine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate." [EC:2.6.1.65, MetaCyc:2.6.1.65-RXN] synonym: "6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.65] synonym: "epsilon-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65] synonym: "N(6)-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65] synonym: "N6-acetyl-beta-lysine aminotransferase activity" EXACT [] xref: EC:2.6.1.65 xref: GO:0047317 xref: MetaCyc:2.6.1.65-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006628 name: aspartate-phenylpyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetic acid." [EC:2.6.1.70, MetaCyc:2.6.1.70-RXN] synonym: "aspartate--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70] synonym: "aspartate-phenylpyruvate aminotransferase activity" EXACT [] synonym: "L-aspartate:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70] xref: EC:2.6.1.70 xref: GO:0047319 xref: MetaCyc:2.6.1.70-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006629 name: D-4-hydroxyphenylglycine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = L-glutamate + 4-hydroxyphenylglyoxylate." [EC:2.6.1.72, MetaCyc:2.6.1.72-RXN] synonym: "D-4-hydroxyphenylglycine aminotransferase activity" EXACT [] synonym: "D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.72] synonym: "D-hydroxyphenylglycine aminotransferase activity" EXACT [EC:2.6.1.72] xref: EC:2.6.1.72 xref: GO:0047320 xref: MetaCyc:2.6.1.72-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006630 name: diphosphate-protein phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: microsomal-membrane protein + diphosphate = pyrophosphate + O-phospho-microsomal-membrane protein." [EC:2.7.99.1, MetaCyc:2.7.99.1-RXN] synonym: "diphosphate:microsomal-membrane-protein O-phosphotransferase activity" BROAD [EC:2.7.99.1] synonym: "DiPPT" RELATED [EC:2.7.99.1] synonym: "pyrophosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1] synonym: "pyrophosphate:protein phosphotransferase activity" EXACT [EC:2.7.99.1] synonym: "triphosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1] synonym: "triphosphate:microsomal-membrane-protein phosphotransferase activity" EXACT [EC:2.7.99.1] xref: EC:2.7.99.1 xref: GO:0047321 xref: MetaCyc:2.7.99.1-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006633 name: phosphoenolpyruvate-glycerone phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroxy-acetone + phosphoenolpyruvate = dihydroxy-acetone-phosphate + pyruvate." [EC:2.7.1.121, MetaCyc:2.7.1.121-RXN] synonym: "phosphoenolpyruvate:glycerone phosphotransferase activity" EXACT [EC:2.7.1.121] xref: EC:2.7.1.121 xref: GO:0047324 xref: MetaCyc:2.7.1.121-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006634 name: inositol tetrakisphosphate 1-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN] synonym: "1D-myo-inositol-tetrakisphosphate 1-kinase activity" EXACT [EC:2.7.1.134] synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.134] synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.134] synonym: "ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.134] synonym: "inositol 3,4,5,6-tetrakisphosphate 1-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 1-kinase activity" EXACT [] synonym: "inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] synonym: "inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] xref: EC:2.7.1.134 xref: GO:0047325 xref: MetaCyc:2.7.1.134-RXN is_a: CCO:F0008190 ! inositol tetrakisphosphate kinase activity [Term] id: CCO:F0006635 name: inositol tetrakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN] synonym: "1D-myo-inositol-tetrakisphosphate 5-kinase activity" EXACT [] synonym: "ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.140] synonym: "inositol 1,3,4,6-tetrakisphosphate 5-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 5-kinase activity" EXACT [] xref: EC:2.7.1.140 xref: GO:0047326 xref: MetaCyc:2.7.1.140-RXN is_a: CCO:F0008190 ! inositol tetrakisphosphate kinase activity [Term] id: CCO:F0006636 name: glycerol-3-phosphate-glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + glycerol-3-phosphate = glucose-6-phosphate + glycerol." [EC:2.7.1.142, MetaCyc:2.7.1.142-RXN] synonym: "sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.142] xref: EC:2.7.1.142 xref: GO:0047327 xref: MetaCyc:2.7.1.142-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006637 name: acyl-phosphate-hexose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid." [EC:2.7.1.61, MetaCyc:2.7.1.61-RXN] synonym: "acyl-phosphate:D-hexose phosphotransferase activity" EXACT [EC:2.7.1.61] synonym: "hexose phosphate:hexose phosphotransferase activity" EXACT [EC:2.7.1.61] xref: EC:2.7.1.61 xref: GO:0047328 xref: MetaCyc:2.7.1.61-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006638 name: phosphoramidate-hexose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3." [EC:2.7.1.62, MetaCyc:2.7.1.62-RXN] synonym: "phosphoramidate-hexose transphosphorylase activity" EXACT [EC:2.7.1.62] synonym: "phosphoramidate:hexose 1-phosphotransferase activity" EXACT [EC:2.7.1.62] synonym: "phosphoramidic-hexose transphosphorylase activity" EXACT [EC:2.7.1.62] xref: EC:2.7.1.62 xref: GO:0047329 xref: MetaCyc:2.7.1.62-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006639 name: polyphosphate-glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate." [EC:2.7.1.63, MetaCyc:2.7.1.63-RXN] subset: gosubset_prok synonym: "polyphosphate glucokinase activity" EXACT [EC:2.7.1.63] synonym: "polyphosphate-D-(+)-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.63] synonym: "polyphosphate-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63] synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63] xref: EC:2.7.1.63 xref: GO:0047330 xref: MetaCyc:2.7.1.63-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006640 name: diphosphate-glycerol phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + pyrophosphate = phosphate + glycerol-3-phosphate." [EC:2.7.1.79, MetaCyc:2.7.1.79-RXN] synonym: "diphosphate:glycerol 1-phosphotransferase activity" EXACT [EC:2.7.1.79] synonym: "PPi-glycerol phosphotransferase activity" EXACT [EC:2.7.1.79] synonym: "pyrophosphate--glycerol phosphotransferase activity" EXACT [EC:2.7.1.79] xref: EC:2.7.1.79 xref: GO:0047331 xref: MetaCyc:2.7.1.79-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006641 name: diphosphate-serine phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + pyrophosphate = phosphate + 3-phospho-serine." [EC:2.7.1.80, MetaCyc:2.7.1.80-RXN] synonym: "diphosphate:L-serine O-phosphotransferase activity" EXACT [EC:2.7.1.80] synonym: "pyrophosphate--serine phosphotransferase activity" EXACT [EC:2.7.1.80] synonym: "pyrophosphate-L-serine phosphotransferase activity" EXACT [EC:2.7.1.80] xref: EC:2.7.1.80 xref: GO:0047332 xref: MetaCyc:2.7.1.80-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006642 name: dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrostreptomycin 6-phosphate + ATP = dihydrostreptomycin 3'-alpha-6-bisphosphate + ADP." [EC:2.7.1.88, MetaCyc:2.7.1.88-RXN] synonym: "ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88] synonym: "ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88] synonym: "dihydrostreptomycin 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.88] synonym: "dihydrostreptomycin-6-phosphate 3'alpha-kinase activity" EXACT [EC:2.7.1.88] xref: EC:2.7.1.88 xref: GO:0047333 xref: MetaCyc:2.7.1.88-RXN is_a: CCO:F0005515 ! aminoglycoside phosphotransferase activity [Term] id: CCO:F0006643 name: diphosphate-fructose-6-phosphate 1-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: fructose-6-phosphate + pyrophosphate = phosphate + fructose-1,6-bisphosphate." [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN] subset: gosubset_prok synonym: "6-phosphofructokinase (diphosphate) activity" EXACT [EC:2.7.1.90] synonym: "6-phosphofructokinase (pyrophosphate) activity" EXACT [EC:2.7.1.90] synonym: "diphosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90] synonym: "diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90] synonym: "inorganic pyrophosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.90] synonym: "inorganic pyrophosphate-phosphofructokinase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate-dependent phosphofructo-1-kinase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate-fructose 6-phosphate phosphotransferase activity" EXACT [EC:2.7.1.90] xref: EC:2.7.1.90 xref: GO:0047334 xref: MetaCyc:2.7.1.90-RXN is_a: CCO:F0001906 ! phosphofructokinase activity [Term] id: CCO:F0006644 name: 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate." [EC:2.7.4.17, MetaCyc:2.7.4.17-RXN] synonym: "1,3-diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] xref: EC:2.7.4.17 xref: GO:0047335 xref: MetaCyc:2.7.4.17-RXN is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0006645 name: 5-methyldeoxycytidine-5'-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: deoxy-5-methylcytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP." [EC:2.7.4.19, MetaCyc:2.7.4.19-RXN] synonym: "ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity" EXACT [EC:2.7.4.19] xref: EC:2.7.4.19 xref: GO:0047336 xref: MetaCyc:2.7.4.19-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0006646 name: dolichyl-diphosphate-polyphosphate phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate." [EC:2.7.4.20, MetaCyc:2.7.4.20-RXN] synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20] synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20] xref: EC:2.7.4.20 xref: GO:0047337 xref: MetaCyc:2.7.4.20-RXN is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0006647 name: UTP:xylose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate." [EC:2.7.7.11, MetaCyc:2.7.7.11-RXN] synonym: "UDP-xylose pyrophosphorylase activity" EXACT [EC:2.7.7.11] synonym: "uridine diphosphoxylose pyrophosphorylase activity" EXACT [EC:2.7.7.11] synonym: "uridylyltransferase, xylose 1-phosphate" EXACT [EC:2.7.7.11] synonym: "UTP-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] synonym: "UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] synonym: "xylose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] synonym: "xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] xref: EC:2.7.7.11 xref: GO:0047338 xref: MetaCyc:2.7.7.11-RXN is_a: CCO:F0008184 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: CCO:F0006648 name: nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate." [EC:2.7.7.28, MetaCyc:2.7.7.28-RXN] synonym: "GDP hexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] synonym: "GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity" NARROW [EC:2.7.7.28] synonym: "GTP:hexose-1-phosphate guanylyltransferase activity" NARROW [] synonym: "guanosine diphosphohexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] synonym: "hexose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.28] synonym: "hexose 1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] synonym: "hexose nucleotidylating enzyme activity" EXACT [EC:2.7.7.28] synonym: "hexose-1-phosphate guanylyltransferase activity" NARROW [] synonym: "NDP hexose pyrophosphorylase activity" EXACT [EC:2.7.7.28] synonym: "NDP-hexose diphosphorylase activity" EXACT [] synonym: "NDP-hexose pyrophosphorylase activity" EXACT [] synonym: "NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] synonym: "NTP:hexose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] synonym: "nucleoside diphosphohexose pyrophosphorylase activity" EXACT [EC:2.7.7.28] synonym: "nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] xref: EC:2.7.7.28 xref: GO:0047339 xref: GO:0047340 xref: MetaCyc:2.7.7.28-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006649 name: fucose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-fucose 1-phosphate + GTP = guanosine diphosphate fucose + diphosphate." [EC:2.7.7.30, MetaCyc:2.7.7.30-RXN] synonym: "GDP fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GDP-fucose diphosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GDP-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GDP-L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GTP:beta-L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30] synonym: "GTP:fucose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "GTP:L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30] synonym: "guanosine diphosphate L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] xref: EC:2.7.7.30 xref: GO:0047341 xref: MetaCyc:2.7.7.30-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006650 name: galactose-1-phosphate thymidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galactose-1-phosphate + dTTP = dTDP-D-galactose + diphosphate." [EC:2.7.7.32, MetaCyc:2.7.7.32-RXN] synonym: "dTDP galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] synonym: "dTDP-galactose diphosphorylase activity" EXACT [EC:2.7.7.32] synonym: "dTDP-galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] synonym: "dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32] synonym: "galactose 1-phosphate thymidylyl transferase activity" EXACT [EC:2.7.7.32] synonym: "thymidine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] synonym: "thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32] xref: EC:2.7.7.32 xref: GO:0047342 xref: MetaCyc:2.7.7.32-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006651 name: glucose-1-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucose-1-phosphate + CTP = CDP-D-glucose + diphosphate." [EC:2.7.7.33, MetaCyc:2.7.7.33-RXN] subset: gosubset_prok synonym: "CDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "CDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.33] synonym: "CDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33] synonym: "CTP:D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33] synonym: "CTP:glucose-1-phosphate cytidylyltransferase activity" EXACT [] synonym: "cytidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "cytidine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "cytidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] xref: EC:2.7.7.33 xref: GO:0047343 xref: MetaCyc:2.7.7.33-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006652 name: glucose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucose-1-phosphate + GTP = GDP-D-glucose + diphosphate." [EC:2.7.7.34, MetaCyc:2.7.7.34-RXN] synonym: "GDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] synonym: "GDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.34] synonym: "GDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] synonym: "GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.34] synonym: "GTP:glucose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] xref: EC:2.7.7.34 xref: GO:0047344 xref: MetaCyc:2.7.7.34-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006653 name: ribose-5-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ribose-5-phosphate + ADP = phosphate + adenosine diphosphate ribose." [EC:2.7.7.35, MetaCyc:2.7.7.35-RXN] synonym: "adenosine diphosphoribose phosphorylase activity" EXACT [EC:2.7.7.35] synonym: "ADP ribose phosphorylase activity" EXACT [EC:2.7.7.35] synonym: "ADP-ribose phosphorylase activity" EXACT [EC:2.7.7.35] synonym: "ADP:D-ribose-5-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.35] synonym: "ADP:ribose-5-phosphate adenylyltransferase activity" EXACT [] xref: EC:2.7.7.35 xref: GO:0047345 xref: MetaCyc:2.7.7.35-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006654 name: aldose-1-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose." [EC:2.7.7.36, MetaCyc:2.7.7.36-RXN] synonym: "adenosine diphosphate glucose:orthophosphate adenylyltransferase activity" EXACT [EC:2.7.7.36] synonym: "adenosine diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "ADP sugar phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "ADP-aldose phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "ADP-sugar phosphorylase activity" BROAD [EC:2.7.7.36] synonym: "ADP:aldose-1-phosphate adenylyltransferase activity" EXACT [] synonym: "ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.36] synonym: "ADPaldose phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "sugar-1-phosphate adenylyltransferase activity" BROAD [EC:2.7.7.36] xref: EC:2.7.7.36 xref: GO:0047346 xref: MetaCyc:2.7.7.36-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006655 name: aldose-1-phosphate nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose." [EC:2.7.7.37, MetaCyc:2.7.7.37-RXN] subset: gosubset_prok synonym: "glucose 1-phosphate inosityltransferase activity" EXACT [EC:2.7.7.37] synonym: "NDP sugar phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "NDP-aldose phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "NDP-sugar phosphorylase activity" BROAD [EC:2.7.7.37] synonym: "NDP:aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "NDPaldose phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "nucleoside diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "sugar nucleotide phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "sugar phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "sugar-1-phosphate nucleotidyltransferase activity" BROAD [EC:2.7.7.37] xref: EC:2.7.7.37 xref: GO:0047347 xref: MetaCyc:2.7.7.37-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006656 name: glycerol-3-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol-3-phosphate + CTP = CDPglycerol + diphosphate." [EC:2.7.7.39, MetaCyc:2.7.7.39-RXN] subset: gosubset_prok synonym: "CDP-glycerol diphosphorylase activity" EXACT [EC:2.7.7.39] synonym: "CDP-glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] synonym: "CTP:glycerol 3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39] synonym: "CTP:glycerol-3-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:sn-glycerol-3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39] synonym: "cytidine diphosphate glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] synonym: "cytidine diphosphoglycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] synonym: "Gro-PCT" RELATED [EC:2.7.7.39] xref: EC:2.7.7.39 xref: GO:0047348 xref: MetaCyc:2.7.7.39-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006657 name: D-ribitol-5-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate." [EC:2.7.7.40, MetaCyc:2.7.7.40-RXN] subset: gosubset_prok synonym: "CDP ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "CDP-ribitol diphosphorylase activity" EXACT [EC:2.7.7.40] synonym: "CDP-ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "CTP:D-ribitol-5-phosphate cytidylyltransferase activity" EXACT [] synonym: "cytidine diphosphate ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "cytidine diphosphoribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "ribitol 5-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.40] xref: EC:2.7.7.40 xref: GO:0047349 xref: MetaCyc:2.7.7.40-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006658 name: glucuronate-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = UDP-D-glucuronate + diphosphate." [EC:2.7.7.44, MetaCyc:2.7.7.44-RXN] synonym: "UDP-D-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "UDP-glucuronate pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "UDP-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "uridine diphosphoglucuronic pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity" EXACT [EC:2.7.7.44] synonym: "UTP:glucuronate-1-phosphate uridylyltransferase activity" EXACT [] xref: EC:2.7.7.44 xref: GO:0047350 xref: MetaCyc:2.7.7.44-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006659 name: guanosine-triphosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 GTP = P1,P4-bis(5'-guanosyl) tetraphosphate + diphosphate." [EC:2.7.7.45, MetaCyc:2.7.7.45-RXN] synonym: "GTP:GTP guanylyltransferase activity" EXACT [] xref: EC:2.7.7.45 xref: GO:0047351 xref: MetaCyc:2.7.7.45-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006660 name: adenylylsulfate-ammonia adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + APS = SO4(2-) (sulfate) + adenosine 5'-phosphoramidate." [EC:2.7.7.51, MetaCyc:2.7.7.51-RXN] synonym: "adenylylsulfate:ammonia adenylyltransferase activity" EXACT [EC:2.7.7.51] synonym: "adenylylsulphate-ammonia adenylyltransferase activity" EXACT [] synonym: "APSAT" RELATED [EC:2.7.7.51] xref: EC:2.7.7.51 xref: GO:0047352 xref: MetaCyc:2.7.7.51-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006661 name: N-methylphosphoethanolamine cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamin + diphosphate." [EC:2.7.7.57, MetaCyc:2.7.7.57-RXN] synonym: "CTP:N-methylethanolamine-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57] synonym: "CTP:N-methylphosphoethanolamine cytidylyltransferase activity" EXACT [] synonym: "CTP:P-MEA cytidylyltransferase activity" EXACT [EC:2.7.7.57] synonym: "monomethylethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57] xref: EC:2.7.7.57 xref: GO:0047353 xref: MetaCyc:2.7.7.57-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006662 name: sphingosine cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine + CDP-choline = sphingosyl-phosphocholine + CMP." [EC:2.7.8.10, MetaCyc:2.7.8.10-RXN] synonym: "CDP-choline-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] synonym: "CDP-choline:sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] synonym: "cytidine diphosphocholine-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] synonym: "phosphorylcholine-sphingosine transferase activity" EXACT [EC:2.7.8.10] synonym: "sphingosine choline phosphotransferase activity" EXACT [] xref: EC:2.7.8.10 xref: GO:0047354 xref: MetaCyc:2.7.8.10-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006663 name: CDP-glycerol glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP." [EC:2.7.8.12, MetaCyc:2.7.8.12-RXN] subset: gosubset_prok synonym: "CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity" EXACT [EC:2.7.8.12] synonym: "CDPglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12] synonym: "CGPTase activity" EXACT [EC:2.7.8.12] synonym: "cytidine diphosphoglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12] synonym: "glycerophosphate synthetase activity" EXACT [EC:2.7.8.12] synonym: "poly(glycerol phosphate) polymerase activity" EXACT [EC:2.7.8.12] synonym: "teichoic acid glycerol transferase activity" EXACT [EC:2.7.8.12] synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12] xref: EC:2.7.8.12 xref: GO:0047355 xref: MetaCyc:2.7.8.12-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006664 name: CDP-ribitol ribitolphosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP." [EC:2.7.8.14, MetaCyc:2.7.8.14-RXN] subset: gosubset_prok synonym: "CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity" EXACT [EC:2.7.8.14] synonym: "CDPribitol ribitolphosphotransferase activity" EXACT [EC:2.7.8.14] synonym: "poly(ribitol phosphate) synthetase activity" EXACT [EC:2.7.8.14] synonym: "polyribitol phosphate polymerase activity" EXACT [EC:2.7.8.14] synonym: "polyribitol phosphate synthetase activity" EXACT [EC:2.7.8.14] synonym: "teichoate synthase activity" EXACT [EC:2.7.8.14] synonym: "teichoate synthetase activity" EXACT [EC:2.7.8.14] synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14] xref: EC:2.7.8.14 xref: GO:0047356 xref: MetaCyc:2.7.8.14-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006665 name: UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + UDP-galactose = UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP." [EC:2.7.8.18, MetaCyc:2.7.8.18-RXN] synonym: "galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "galactosyl phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18] xref: EC:2.7.8.18 xref: GO:0047357 xref: MetaCyc:2.7.8.18-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006666 name: UDP-glucose-glycoprotein glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP." [EC:2.7.8.19, MetaCyc:2.7.8.19-RXN] synonym: "Glc-phosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "GlcPTase activity" EXACT [EC:2.7.8.19] synonym: "UDP-glucose:glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "UDPglucose-glycoprotein glucose phosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19] xref: EC:2.7.8.19 xref: GO:0047358 xref: MetaCyc:2.7.8.19-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006667 name: 1-alkenyl-2-acylglycerol choline phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP." [EC:2.7.8.22, MetaCyc:2.7.8.22-RXN] synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity" EXACT [EC:2.7.8.22] synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.22] xref: EC:2.7.8.22 xref: GO:0047359 xref: MetaCyc:2.7.8.22-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006668 name: undecaprenyl-phosphate galactose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: undecaprenyl phosphate + UDP-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP." [EC:2.7.8.6, MetaCyc:2.7.8.6-RXN] subset: gosubset_prok synonym: "poly(isoprenol)-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "Poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "poly(isoprenyl)phosphate galactosephosphatetransferase activity" EXACT [EC:2.7.8.6] synonym: "UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "undecaprenyl phosphate galactosyl-1-phosphate transferase activity" EXACT [EC:2.7.8.6] xref: EC:2.7.8.6 xref: GO:0047360 xref: MetaCyc:2.7.8.6-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006669 name: phosphomannan mannosephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP." [EC:2.7.8.9, MetaCyc:2.7.8.9-RXN] synonym: "GDP-mannose:phosphomannan mannose phosphotransferase activity" EXACT [EC:2.7.8.9] xref: EC:2.7.8.9 xref: GO:0047361 xref: MetaCyc:2.7.8.9-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006670 name: thiosulfate-dithiol sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: dithioerythritol + S2O3(2-) (thiosulfate) = H2S + dithioerythritol disulfide + SO3(2-) (sulfite)." [EC:2.8.1.5, MetaCyc:2.8.1.5-RXN] synonym: "thiosulfate reductase activity" EXACT [EC:2.8.1.5] synonym: "thiosulfate:dithioerythritol sulfurtransferase activity" EXACT [EC:2.8.1.5] synonym: "thiosulphate-dithiol sulphurtransferase activity" EXACT [] synonym: "TSR" RELATED [EC:2.8.1.5] xref: EC:2.8.1.5 xref: GO:0047362 xref: MetaCyc:2.8.1.5-RXN is_a: CCO:F0003355 ! sulfurtransferase activity [Term] id: CCO:F0006671 name: triglucosylalkylacylglycerol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate." [EC:2.8.2.19, MetaCyc:2.8.2.19-RXN] synonym: "3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity" EXACT [EC:2.8.2.19] synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT [] synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" EXACT [EC:2.8.2.19] xref: EC:2.8.2.19 xref: GO:0047363 xref: MetaCyc:2.8.2.19-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0006672 name: desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: desulfoglucotropeolin + 3'-phosphoadenosine 5'-phosphosulfate = glucotropeolin + adenosine 3',5'-bisphosphate." [EC:2.8.2.24, MetaCyc:2.8.2.24-RXN] synonym: "3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] synonym: "3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] synonym: "desulphoglucosinolate sulphotransferase activity" EXACT [] synonym: "PAPS-desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] xref: EC:2.8.2.24 xref: GO:0047364 xref: MetaCyc:2.8.2.24-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0006673 name: quercetin-3-sulfate 3'-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin 3-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3'-bissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.26, MetaCyc:2.8.2.26-RXN] synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "flavonol 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "PAPS:flavonol 3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "quercetin-3-sulphate 3'-sulphotransferase activity" EXACT [] xref: EC:2.8.2.26 xref: GO:0047365 xref: MetaCyc:2.8.2.26-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0006674 name: quercetin-3-sulfate 4'-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin 3-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,4'-bissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.27, MetaCyc:2.8.2.27-RXN] synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] synonym: "flavonol 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] synonym: "PAPS:flavonol 3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] synonym: "quercetin-3-sulphate 4'-sulphotransferase activity" EXACT [] xref: EC:2.8.2.27 xref: GO:0047366 xref: MetaCyc:2.8.2.27-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0006675 name: quercetin-3,3'-bissulfate 7-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.28, MetaCyc:2.8.2.28-RXN] synonym: "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "flavonol 7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "quercetin-3,3'-bissulphate 7-sulphotransferase activity" EXACT [] xref: EC:2.8.2.28 xref: GO:0047367 xref: MetaCyc:2.8.2.28-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0006676 name: UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine 4-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = UDP-N-acetyl-D-galactosamine 4,6-bissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.7, MetaCyc:2.8.2.7-RXN] synonym: "3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity" EXACT [EC:2.8.2.7] synonym: "UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity" EXACT [] synonym: "uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7] synonym: "uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7] xref: EC:2.8.2.7 xref: GO:0047368 xref: MetaCyc:2.8.2.7-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0006677 name: succinate-hydroxymethylglutarate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate." [EC:2.8.3.13, MetaCyc:2.8.3.13-RXN] synonym: "dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity" EXACT [EC:2.8.3.13] synonym: "hydroxymethylglutarate coenzyme A-transferase activity" EXACT [EC:2.8.3.13] synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" EXACT [EC:2.8.3.13] xref: EC:2.8.3.13 xref: GO:0047369 xref: MetaCyc:2.8.3.13-RXN is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0006678 name: succinate-citramalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate." [EC:2.8.3.7, MetaCyc:2.8.3.7-RXN] synonym: "citramalate coenzyme A-transferase activity" EXACT [EC:2.8.3.7] synonym: "itaconate CoA-transferase activity" EXACT [EC:2.8.3.7] synonym: "succinyl coenzyme A-citramalyl coenzyme A transferase activity" EXACT [EC:2.8.3.7] synonym: "succinyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.7] xref: EC:2.8.3.7 xref: GO:0047370 xref: MetaCyc:2.8.3.7-RXN is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0006679 name: butyrate-acetoacetate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + butyryl-CoA = acetoacetyl-CoA + butyrate." [EC:2.8.3.9, MetaCyc:2.8.3.9-RXN] subset: gosubset_prok synonym: "butanoyl-CoA:acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9] synonym: "butyryl coenzyme A-acetoacetate coenzyme A-transferase activity" EXACT [EC:2.8.3.9] synonym: "butyryl-CoA-acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9] xref: EC:2.8.3.9 xref: GO:0047371 xref: MetaCyc:2.8.3.9-RXN is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0006680 name: acylglycerol lipase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN] subset: gosubset_prok synonym: "fatty acyl monoester lipase activity" EXACT [EC:3.1.1.23] synonym: "glycerol-ester acylhydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerol hydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerol lipase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerolipase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceridase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceride hydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceride lipase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceridyllipase activity" EXACT [EC:3.1.1.23] xref: EC:3.1.1.23 xref: GO:0047372 xref: MetaCyc:3.1.1.23-RXN xref: Reactome:83299 is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0003111 ! lipase activity [Term] id: CCO:F0006681 name: acetoxybutynylbithiophene deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 5-(4-acetoxybut-1-ynyl)-2-2'-bithiophene = acetate + 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene." [EC:3.1.1.54, MetaCyc:3.1.1.54-RXN] synonym: "5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity" EXACT [EC:3.1.1.54] synonym: "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity" EXACT [EC:3.1.1.54] synonym: "acetoxybutynylbithiophene esterase activity" EXACT [EC:3.1.1.54] xref: EC:3.1.1.54 xref: GO:0047373 xref: MetaCyc:3.1.1.54-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006682 name: methylumbelliferyl-acetate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = acetate + 4-methylumbelliferone." [EC:3.1.1.56, MetaCyc:3.1.1.56-RXN] synonym: "4-methylumbelliferyl-acetate acylhydrolase activity" EXACT [EC:3.1.1.56] synonym: "esterase D activity" RELATED [EC:3.1.1.56] xref: EC:3.1.1.56 xref: GO:0047374 xref: MetaCyc:3.1.1.56-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006683 name: N-acetylgalactosaminoglycan deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan." [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN] synonym: "N-acetyl galactosaminoglycan deacetylase activity" EXACT [EC:3.1.1.58] synonym: "N-acetyl-D-galactosaminoglycan acetylhydrolase activity" EXACT [EC:3.1.1.58] synonym: "polysaccharide deacetylase activity" EXACT [EC:3.1.1.58] synonym: "Vi-polysaccharide deacetylase activity" EXACT [EC:3.1.1.58] xref: EC:3.1.1.58 xref: GO:0047375 xref: MetaCyc:3.1.1.58-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006684 name: all-trans-retinyl-palmitate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + retinol-palmitate = palmitate + retinol." [EC:3.1.1.64, MetaCyc:3.1.1.64-RXN] synonym: "all-trans-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.64] xref: EC:3.1.1.64 xref: GO:0047376 xref: MetaCyc:3.1.1.64-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006685 name: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene = acetate + 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene." [EC:3.1.1.66, MetaCyc:3.1.1.66-RXN] synonym: "3,4-diacetoxybutinylbithiophene:4-acetate esterase activity" EXACT [EC:3.1.1.66] synonym: "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity" EXACT [EC:3.1.1.66] synonym: "diacetoxybutynylbithiophene acetate esterase activity" EXACT [EC:3.1.1.66] xref: EC:3.1.1.66 xref: GO:0047377 xref: MetaCyc:3.1.1.66-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006686 name: acetylalkylglycerol acetylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 2-acetyl-1-alkyl-sn-glycerol = acetate + 1-alkyl-sn-glycerol." [EC:3.1.1.71, MetaCyc:3.1.1.71-RXN] synonym: "2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity" EXACT [EC:3.1.1.71] synonym: "alkylacetylglycerol acetylhydrolase activity" EXACT [EC:3.1.1.71] xref: EC:3.1.1.71 xref: GO:0047378 xref: MetaCyc:3.1.1.71-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006687 name: ADP-dependent short-chain-acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA." [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN] synonym: "ADP-dependent-short-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] synonym: "propionyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18] synonym: "propionyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] synonym: "propionyl-CoA thioesterase activity" EXACT [EC:3.1.2.18] synonym: "short-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18] synonym: "short-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] synonym: "short-chain acyl-CoA thioesterase activity" EXACT [EC:3.1.2.18] xref: EC:3.1.2.18 xref: GO:0047379 xref: MetaCyc:3.1.2.18-RXN is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0006688 name: ADP-dependent medium-chain-acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA." [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN] subset: gosubset_prok synonym: "ADP-dependent-medium-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain hydrolase activity" EXACT [EC:3.1.2.19] synonym: "myristoyl-CoA thioesterase activity" EXACT [EC:3.1.2.19] xref: EC:3.1.2.19 xref: GO:0047380 xref: MetaCyc:3.1.2.19-RXN is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0006689 name: dodecanoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]." [EC:3.1.2.21, MetaCyc:3.1.2.21-RXN] synonym: "dodecanoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "dodecanoyl-ACP hydrolase activity" EXACT [] synonym: "dodecanoyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21] synonym: "dodecyl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21] synonym: "dodecyl-acyl-carrier protein hydrolase" BROAD [EC:3.1.2.21] synonym: "lauroyl-[acyl-carrier-protein] hydrolase activity" EXACT [] synonym: "lauroyl-ACP hydrolase activity" EXACT [] synonym: "lauryl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21] synonym: "lauryl-acyl-carrier protein hydrolase activity" EXACT [EC:3.1.2.21] synonym: "lauryl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21] xref: EC:3.1.2.21 xref: GO:0016294 xref: GO:0047381 xref: MetaCyc:3.1.2.21-RXN is_a: CCO:F0003110 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: CCO:F0006690 name: methylphosphothioglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + S-methyl-3-phospho-1-thio-D-glycerate = phosphate + S-methyl-1-thio-D-glycerate." [EC:3.1.3.14, MetaCyc:3.1.3.14-RXN] synonym: "methylthiophosphoglycerate phosphatase activity" EXACT [EC:3.1.3.14] synonym: "S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity" EXACT [EC:3.1.3.14] xref: EC:3.1.3.14 xref: GO:0047382 xref: MetaCyc:3.1.3.14-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0006691 name: guanidinodeoxy-scyllo-inositol-4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate = phosphate + 1-guanidino-1-deoxy-scyllo-inositol." [EC:3.1.3.40, MetaCyc:3.1.3.40-RXN] synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity" EXACT [EC:3.1.3.40] synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.40] synonym: "1-guanidino-scyllo-inositol 4-phosphatase activity" EXACT [EC:3.1.3.40] xref: EC:3.1.3.40 xref: GO:0047383 xref: MetaCyc:3.1.3.40-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0006694 name: fructose-2,6-bisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + D-fructose 2,6-bisphosphate = phosphate + fructose-2-phosphate." [EC:3.1.3.54, MetaCyc:3.1.3.54-RXN] synonym: "beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] synonym: "D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] synonym: "fructose 2,6-bisphosphate-6-phosphohydrolase activity" EXACT [EC:3.1.3.54] synonym: "fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] xref: EC:3.1.3.54 xref: GO:0047386 xref: MetaCyc:3.1.3.54-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0006695 name: serine-ethanolaminephosphate phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + serine phosphoethanolamine = phosphoryl-ethanolamine + L-serine." [EC:3.1.4.13, MetaCyc:3.1.4.13-RXN] subset: gosubset_prok synonym: "SEP diesterase activity" EXACT [EC:3.1.4.13] synonym: "serine ethanolamine phosphodiester phosphodiesterase activity" EXACT [EC:3.1.4.13] synonym: "serine-phosphoethanolamine ethanolaminephosphohydrolase activity" EXACT [EC:3.1.4.13] xref: EC:3.1.4.13 xref: GO:0047387 xref: MetaCyc:3.1.4.13-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006696 name: adenylyl-[glutamate-ammonia ligase] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + adenylyl-GS = glutaminesyn-oligomer + AMP." [EC:3.1.4.15, MetaCyc:3.1.4.15-RXN] synonym: "adenylyl(glutamine synthetase) hydrolase activity" EXACT [EC:3.1.4.15] synonym: "adenylyl-glutamate-ammonia ligase hydrolase activity" EXACT [EC:3.1.4.15] synonym: "adenylyl-glutamine-synthetasehydrolase activity" EXACT [EC:3.1.4.15] synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity" EXACT [EC:3.1.4.15] xref: EC:3.1.4.15 xref: GO:0047388 xref: MetaCyc:3.1.4.15-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006697 name: glycerophosphocholine phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN] subset: gosubset_prok synonym: "glycerolphosphorylcholine phosphodiesterase activity" EXACT [EC:3.1.4.2] synonym: "glycerophosphinicocholine diesterase activity" EXACT [EC:3.1.4.2] synonym: "glycerophosphohydrolase activity" EXACT [EC:3.1.4.2] synonym: "glycerylphosphorylcholinediesterase activity" EXACT [EC:3.1.4.2] synonym: "sn-glycero-3-phosphocholine glycerophosphohydrolase activity" EXACT [EC:3.1.4.2] synonym: "sn-glycero-3-phosphorylcholine diesterase activity" EXACT [EC:3.1.4.2] xref: EC:3.1.4.2 xref: GO:0047389 xref: MetaCyc:3.1.4.2-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006698 name: glycerophosphocholine cholinephosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = phosphoryl-choline + glycerol." [EC:3.1.4.38, MetaCyc:3.1.4.38-RXN] synonym: "L-3-glycerylphosphinicocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38] synonym: "sn-glycero-3-phosphocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38] xref: EC:3.1.4.38 xref: GO:0047390 xref: MetaCyc:3.1.4.38-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006699 name: alkylglycerophosphoethanolamine phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanol-amine + 1-alkyl-sn-glycerol 3-phosphate." [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN] synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity" EXACT [EC:3.1.4.39] synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39] xref: EC:3.1.4.39 xref: GO:0047391 xref: MetaCyc:3.1.4.39-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006700 name: CMP-N-acylneuraminate phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP." [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN] synonym: "CMP-N-acetylneuraminate hydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-N-acylneuraminate N-acylneuraminohydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-N-acylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-sialate hydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-sialic acid hydrolase activity" EXACT [EC:3.1.4.40] synonym: "cytidine monophosphate-N-acetylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40] synonym: "cytidine monophosphosialate hydrolase activity" EXACT [EC:3.1.4.40] synonym: "cytidine monophosphosialic hydrolase activity" EXACT [EC:3.1.4.40] xref: EC:3.1.4.40 xref: GO:0047392 xref: MetaCyc:3.1.4.40-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006701 name: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + glycerol 1,2-cyclic phosphate = glycerol-3-phosphate." [EC:3.1.4.42, MetaCyc:3.1.4.42-RXN] synonym: "rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity" EXACT [EC:3.1.4.42] synonym: "rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity" EXACT [EC:3.1.4.42] xref: EC:3.1.4.42 xref: GO:0047393 xref: MetaCyc:3.1.4.42-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006702 name: glycerophosphoinositol inositolphosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol." [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN] subset: gosubset_prok synonym: "1,2-cyclic-inositol-phosphate phosphodiesterase activity" EXACT [] synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] xref: EC:3.1.4.43 xref: GO:0047394 xref: MetaCyc:3.1.4.43-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006703 name: glycerophosphoinositol glycerophosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + sn-glycero-3-phospho-1-inositol = glycerol-3-phosphate + inositol." [EC:3.1.4.44, MetaCyc:3.1.4.44-RXN] synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] synonym: "sn-glycero(3)phosphoinositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] synonym: "sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] xref: EC:3.1.4.44 xref: GO:0047395 xref: MetaCyc:3.1.4.44-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006704 name: glycosylphosphatidylinositol diacylglycerol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN] subset: gosubset_prok synonym: "(glycosyl)phosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14] synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]" RELATED [EC:4.6.1.14] synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity" EXACT [EC:4.6.1.14] synonym: "glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity" EXACT [EC:4.6.1.14] synonym: "glycosylphosphatidylinositol-phospholipase C activity" NARROW [EC:4.6.1.14] synonym: "glycosylphosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14] synonym: "GPI-PLC activity" EXACT [EC:4.6.1.14] synonym: "GPI-specific phospholipase C activity" EXACT [EC:4.6.1.14] synonym: "variant-surface-glycoprotein phospholipase C activity" EXACT [] synonym: "VSG-lipase activity" EXACT [EC:4.6.1.14] xref: EC:4.6.1.14 xref: GO:0047396 xref: MetaCyc:3.1.4.47-RXN is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003413 ! phosphorus-oxygen lyase activity [Term] id: CCO:F0006705 name: dolichylphosphate-glucose phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose." [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN] synonym: "Dol-P-Glc phosphodiesterase activity" EXACT [EC:3.1.4.48] synonym: "dolichol phosphoglucose phosphodiesterase activity" EXACT [EC:3.1.4.48] synonym: "dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.48] synonym: "dolichyl-phosphate-glucose phosphodiesterase activity" EXACT [] xref: EC:3.1.4.48 xref: GO:0047397 xref: MetaCyc:3.1.4.48-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006706 name: dolichylphosphate-mannose phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose." [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN] synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.49] synonym: "mannosylphosphodolichol phosphodiesterase activity" EXACT [EC:3.1.4.49] xref: EC:3.1.4.49 xref: GO:0047398 xref: MetaCyc:3.1.4.49-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006707 name: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate." [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN] synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity" EXACT [EC:3.1.4.51] synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.51] xref: EC:3.1.4.51 xref: GO:0047399 xref: MetaCyc:3.1.4.51-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0006708 name: phosphonoacetate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + phosphonoacetate = phosphate + acetate." [EC:3.11.1.2, MetaCyc:3.11.1.2-RXN] synonym: "phosphonoacetate phosphonohydrolase activity" EXACT [EC:3.11.1.2] xref: EC:3.11.1.2 xref: GO:0047400 xref: MetaCyc:3.11.1.2-RXN is_a: CCO:F0003394 ! hydrolase activity, acting on acid carbon-phosphorus bonds [Term] id: CCO:F0006709 name: trithionate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + trithionate = 2 H+ + SO4(2-) (sulfate) + S2O3(2-)." [EC:3.12.1.1, MetaCyc:3.12.1.1-RXN] synonym: "trithionate thiosulfohydrolase activity" EXACT [EC:3.12.1.1] xref: EC:3.12.1.1 xref: GO:0047401 xref: MetaCyc:3.12.1.1-RXN is_a: CCO:F0003395 ! hydrolase activity, acting on acid sulfur-sulfur bonds [Term] id: CCO:F0006710 name: protein-glucosylgalactosylhydroxylysine glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose." [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN] synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity" EXACT [EC:3.2.1.107] synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" EXACT [EC:3.2.1.107] xref: EC:3.2.1.107 xref: GO:0047402 xref: MetaCyc:3.2.1.107-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006711 name: lacto-N-biosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc." [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN] synonym: "oligosaccharide lacto-N-biosylhydrolase activity" RELATED [EC:3.2.1.140] xref: EC:3.2.1.140 xref: GO:0047403 xref: MetaCyc:3.2.1.140-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006712 name: glucuronosyl-disulfoglucosamine glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2-,6-disulfo-D-glucosamine." [EC:3.2.1.56, MetaCyc:3.2.1.56-RXN] synonym: "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56] synonym: "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56] synonym: "glucuronosyl-disulphoglucosamine glucuronidase activity" EXACT [] xref: EC:3.2.1.56 xref: GO:0047404 xref: MetaCyc:3.2.1.56-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006713 name: pyrimidine-5'-nucleotide nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine." [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN] synonym: "Pyr5N activity" EXACT [EC:3.2.2.10] synonym: "pyrimidine nucleotide N-ribosidase activity" EXACT [EC:3.2.2.10] synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" EXACT [EC:3.2.2.10] xref: EC:3.2.2.10 xref: GO:0047405 xref: MetaCyc:3.2.2.10-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0006714 name: beta-aspartyl-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-beta-aspartyl-N-acetyl-D-glucosaminylamine = L-asparagine + N-acetyl-D-glucosamine." [EC:3.2.2.11, MetaCyc:3.2.2.11-RXN] synonym: "1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity" EXACT [EC:3.2.2.11] synonym: "beta-aspartylacetylglucosaminidase activity" EXACT [EC:3.2.2.11] xref: EC:3.2.2.11 xref: GO:0047406 xref: MetaCyc:3.2.2.11-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0006715 name: ADP-ribosyl-[dinitrogen reductase] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]." [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN] subset: gosubset_prok synonym: "ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.24] synonym: "ADP-ribosyl glycohydrolase activity" EXACT [EC:3.2.2.24] synonym: "ADP-ribosyl-dinitrogen reductase hydrolase activity" EXACT [EC:3.2.2.24] synonym: "azoferredoxin glycosidase activity" EXACT [EC:3.2.2.24] synonym: "azoferredoxin-activating enzymes" RELATED [EC:3.2.2.24] synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [EC:3.2.2.24] synonym: "dinitrogenase reductase-activating glycohydrolase activity" EXACT [EC:3.2.2.24] xref: EC:3.2.2.24 xref: GO:0047407 xref: MetaCyc:3.2.2.24-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0006716 name: alkenylglycerophosphocholine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde." [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN] synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity" EXACT [EC:3.3.2.2] synonym: "lysoplasmalogenase activity" EXACT [EC:3.3.2.2] xref: EC:3.3.2.2 xref: GO:0047408 xref: MetaCyc:3.3.2.2-RXN is_a: CCO:F0003373 ! ether hydrolase activity [Term] id: CCO:F0006717 name: alkenylglycerophosphoethanolamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde." [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN] synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" EXACT [EC:3.3.2.5] xref: EC:3.3.2.5 xref: GO:0047409 xref: MetaCyc:3.3.2.5-RXN is_a: CCO:F0003373 ! ether hydrolase activity [Term] id: CCO:F0006718 name: N-formylmethionylaminoacyl-tRNA deformylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate." [EC:3.5.1.27, MetaCyc:3.5.1.27-RXN] synonym: "N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity" EXACT [EC:3.5.1.27] xref: EC:3.5.1.27 xref: GO:0047410 xref: MetaCyc:3.5.1.27-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006719 name: 2-(acetamidomethylene)succinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate." [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN] synonym: "2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.29] synonym: "alpha-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.29] xref: EC:3.5.1.29 xref: GO:0047411 xref: MetaCyc:3.5.1.29-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006720 name: N-(long-chain-acyl)ethanolamine deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanol-amine + a fatty acid." [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN] synonym: "acylethanolamine amidase activity" EXACT [] synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT [] synonym: "N-acylethanolamine amidohydrolase activity" EXACT [] xref: EC:3.5.1.60 xref: GO:0047412 xref: MetaCyc:3.5.1.60-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006721 name: N(alpha)-benzyloxycarbonylleucine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N(alpha)-benzyloxycarbonyl-L-leucine = L-leucine + CO2 + benzyl alcohol." [EC:3.5.1.64, MetaCyc:3.5.1.64-RXN] synonym: "alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64] synonym: "benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64] synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV" RELATED [EC:3.5.1.64] synonym: "nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64] synonym: "nalpha-benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64] xref: EC:3.5.1.64 xref: GO:0047413 xref: MetaCyc:3.5.1.64-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006722 name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + 2-(hydroxymethyl)-3-(acetamidomethylene)succinate = CO2 + NH3 + 2-(hydroxymethyl)-4-oxobutanoate + acetate." [EC:3.5.1.66, MetaCyc:3.5.1.66-RXN] synonym: "2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.66] synonym: "alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.66] synonym: "compound B hydrolase activity" EXACT [EC:3.5.1.66] xref: EC:3.5.1.66 xref: GO:0047414 xref: MetaCyc:3.5.1.66-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006723 name: D-benzoylarginine-4-nitroanilide amidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-benzoyl-D-arginine-4-nitroanilide = N-benzoyl-D-arginine + 4-nitroaniline." [EC:3.5.1.72, MetaCyc:3.5.1.72-RXN] synonym: "benzoyl-D-arginine arylamidase activity" EXACT [EC:3.5.1.72] synonym: "D-BAPA-ase activity" EXACT [EC:3.5.1.72] synonym: "N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity" EXACT [EC:3.5.1.72] xref: EC:3.5.1.72 xref: GO:0047415 xref: MetaCyc:3.5.1.72-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006724 name: arylalkyl acylamidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine." [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN] subset: gosubset_prok synonym: "aralkyl acylamidase activity" EXACT [EC:3.5.1.76] synonym: "N-acetylarylalkylamine amidohydrolase activity" EXACT [EC:3.5.1.76] xref: EC:3.5.1.76 xref: GO:0047416 xref: MetaCyc:3.5.1.76-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006725 name: N-carbamoyl-D-amino acid hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid." [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN] subset: gosubset_prok synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.77] xref: EC:3.5.1.77 xref: GO:0047417 xref: MetaCyc:3.5.1.77-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006726 name: phthalyl amidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine." [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN] synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79] synonym: "phthalyl-amide amidohydrolase activity" EXACT [EC:3.5.1.79] xref: EC:3.5.1.79 xref: GO:0047418 xref: MetaCyc:3.5.1.79-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006727 name: N-acetylgalactosamine-6-phosphate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [EC:3.5.1.-, MetaCyc:3.5.1.80-RXN] xref: EC:3.5.1.- xref: GO:0047419 xref: MetaCyc:3.5.1.80-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006728 name: N-acyl-D-amino-acid deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid." [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN] subset: gosubset_prok synonym: "D-aminoacylase activity" EXACT [EC:3.5.1.81] synonym: "N-acyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.81] xref: EC:3.5.1.81 xref: GO:0047420 xref: MetaCyc:3.5.1.81-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006729 name: N-acyl-D-glutamate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acyl-D-glutamate = D-glutamate + carboxylate." [EC:3.5.1.82, MetaCyc:3.5.1.82-RXN] subset: gosubset_prok synonym: "N-acyl-D-glutamate amidohydrolase activity" EXACT [EC:3.5.1.82] xref: EC:3.5.1.82 xref: GO:0047421 xref: MetaCyc:3.5.1.82-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006730 name: N-acyl-D-aspartate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acyl-D-aspartate = D-aspartate + carboxylate." [EC:3.5.1.83, MetaCyc:3.5.1.83-RXN] subset: gosubset_prok synonym: "N-acyl-D-aspartate amidohydrolase activity" EXACT [EC:3.5.1.83] xref: EC:3.5.1.83 xref: GO:0047422 xref: MetaCyc:3.5.1.83-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006731 name: N-methylhydantoinase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + N-methylhydantoin + ATP = phosphate + N-carbamoylsarcosine + ADP." [EC:3.5.2.14, MetaCyc:3.5.2.14-RXN] subset: gosubset_prok synonym: "methylhydantoin amidase activity" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoin hydrolase activity" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoinase (ATP-hydrolysing)" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoinase activity" EXACT [EC:3.5.2.14] synonym: "N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.14] xref: EC:3.5.2.14 xref: GO:0047423 xref: MetaCyc:3.5.2.14-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0006732 name: methylenediurea deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + NH(2)-CO-NH-CH(2)-NH-CO-NH(2) = CO2 + 2 NH3 + N-hydroxymethylurea." [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN] subset: gosubset_prok synonym: "methylenediurea aminohydrolase activity" EXACT [EC:3.5.3.21] synonym: "methylenediurease activity" EXACT [EC:3.5.3.21] xref: EC:3.5.3.21 xref: GO:0047424 xref: MetaCyc:3.5.3.21-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0006733 name: 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-pyrroline-4-hydroxy-2-carboxylate = NH3 + 2,5-dioxopentanoate." [EC:3.5.4.22, MetaCyc:3.5.4.22-RXN] synonym: "1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)" EXACT [EC:3.5.4.22] synonym: "HPC deaminase activity" EXACT [EC:3.5.4.22] xref: EC:3.5.4.22 xref: GO:0047425 xref: MetaCyc:3.5.4.22-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0006734 name: ricinine nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone." [EC:3.5.5.2, MetaCyc:3.5.5.2-RXN] synonym: "ricinine aminohydrolase activity" EXACT [EC:3.5.5.2] xref: EC:3.5.5.2 xref: GO:0047426 xref: MetaCyc:3.5.5.2-RXN is_a: CCO:F0000053 ! nitrilase activity [Term] id: CCO:F0006735 name: cyanoalanine nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + 3-cyano-L-alanine = NH3 + L-aspartate." [EC:3.5.5.4, MetaCyc:3.5.5.4-RXN] synonym: "3-cyano-L-alanine aminohydrolase activity" EXACT [EC:3.5.5.4] synonym: "beta-cyanoalanine nitrilase activity" EXACT [EC:3.5.5.4] xref: EC:3.5.5.4 xref: GO:0047427 xref: MetaCyc:3.5.5.4-RXN is_a: CCO:F0000053 ! nitrilase activity [Term] id: CCO:F0006736 name: arylacetonitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3." [EC:3.5.5.5, MetaCyc:3.5.5.5-RXN] synonym: "arylacetonitrile aminohydrolase activity" EXACT [EC:3.5.5.5] xref: EC:3.5.5.5 xref: GO:0047428 xref: MetaCyc:3.5.5.5-RXN is_a: CCO:F0000053 ! nitrilase activity [Term] id: CCO:F0006737 name: nucleoside-triphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide." [EC:3.6.1.19, MetaCyc:3.6.1.19-RXN] subset: gosubset_prok synonym: "nucleoside-triphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.19] synonym: "nucleoside-triphosphate pyrophosphatase activity" EXACT [] xref: EC:3.6.1.19 xref: GO:0047429 xref: MetaCyc:3.6.1.19-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0006738 name: oligosaccharide-diphosphodolichol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate." [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN] synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" EXACT [EC:3.6.1.44] synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT [] xref: EC:3.6.1.44 xref: GO:0047430 xref: MetaCyc:3.6.1.44-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0006739 name: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate = CO2 + 3-hydroxy-2-methylpyridine-5-carboxylate." [EC:4.1.1.51, MetaCyc:4.1.1.51-RXN] synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)" EXACT [EC:4.1.1.51] synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity" EXACT [EC:4.1.1.51] xref: EC:4.1.1.51 xref: GO:0047431 xref: MetaCyc:4.1.1.51-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006740 name: 2,2-dialkylglycine decarboxylase (pyruvate) activity namespace: molecular_function def: "Catalysis of the reaction: 2,2-dialkylglycine + pyruvate = dialkyl ketone + L-alanine + CO2." [EC:4.1.1.64, MetaCyc:4.1.1.64-RXN] subset: gosubset_prok synonym: "2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity" EXACT [EC:4.1.1.64] synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring)" EXACT [EC:4.1.1.64] synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)" EXACT [EC:4.1.1.64] synonym: "alpha-dialkyl amino acid transaminase activity" EXACT [EC:4.1.1.64] synonym: "dialkyl amino acid (pyruvate) decarboxylase activity" EXACT [EC:4.1.1.64] synonym: "dialkylamino-acid decarboxylase (pyruvate)" EXACT [EC:4.1.1.64] synonym: "L-alanine-alpha-ketobutyrate aminotransferase activity" EXACT [EC:4.1.1.64] xref: EC:4.1.1.64 xref: GO:0047432 xref: MetaCyc:4.1.1.64-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006741 name: branched-chain-2-oxoacid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO2." [EC:4.1.1.72, MetaCyc:4.1.1.72-RXN] synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)" EXACT [EC:4.1.1.72] synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.72] synonym: "BCKA" RELATED [EC:4.1.1.72] synonym: "branched-chain alpha-keto acid decarboxylase activity" EXACT [EC:4.1.1.72] synonym: "branched-chain keto acid decarboxylase activity" EXACT [EC:4.1.1.72] synonym: "branched-chain oxo acid decarboxylase activity" EXACT [EC:4.1.1.72] xref: EC:4.1.1.72 xref: GO:0047433 xref: MetaCyc:4.1.1.72-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006742 name: indolepyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde." [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN] subset: gosubset_prok synonym: "3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]" RELATED [EC:4.1.1.74] synonym: "3-(indol-3-yl)pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74] synonym: "indol-3-yl-pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74] synonym: "indole-3-pyruvate decarboxylase activity" EXACT [EC:4.1.1.74] xref: EC:4.1.1.74 xref: GO:0047434 xref: MetaCyc:4.1.1.74-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006743 name: 5-guanidino-2-oxopentanoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-guanidino-2-oxo-pentanoate = CO2 + 4-guanidinobutanoate." [EC:4.1.1.75, MetaCyc:4.1.1.75-RXN] synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)" EXACT [EC:4.1.1.75] synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.75] synonym: "2-oxo-5-guanidinopentanoate decarboxylase activity" EXACT [EC:4.1.1.75] synonym: "2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75] synonym: "alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75] xref: EC:4.1.1.75 xref: GO:0047435 xref: MetaCyc:4.1.1.75-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006744 name: arylmalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aryl-2-methylmalonate = CO2 + 2-arylpropionate." [EC:4.1.1.76, MetaCyc:4.1.1.76-RXN] subset: gosubset_prok synonym: "2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)" EXACT [EC:4.1.1.76] synonym: "2-aryl-2-methylmalonate carboxy-lyase activity" EXACT [EC:4.1.1.76] synonym: "AMDASE" RELATED [EC:4.1.1.76] synonym: "AMDase activity" EXACT [EC:4.1.1.76] xref: EC:4.1.1.76 xref: GO:0047436 xref: MetaCyc:4.1.1.76-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006745 name: 4-oxalocrotonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate." [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN] subset: gosubset_prok synonym: "4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.1.1.77] synonym: "4-oxalocrotonate carboxy-lyase activity" EXACT [EC:4.1.1.77] xref: EC:4.1.1.77 xref: GO:0047437 xref: MetaCyc:4.1.1.77-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006746 name: 2-dehydro-3-deoxy-L-pentonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN] synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.18] synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.18] synonym: "2-keto-3-deoxy-D-xylonate aldolase activity" EXACT [EC:4.1.2.18] synonym: "2-keto-3-deoxy-L-arabonate aldolase activity" NARROW [EC:4.1.2.18] synonym: "2-keto-3-deoxy-L-pentonate aldolase activity" EXACT [EC:4.1.2.18] synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.18] xref: EC:4.1.2.18 xref: GO:0047438 xref: MetaCyc:4.1.2.18-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006747 name: 3-deoxy-D-manno-octulosonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate." [EC:4.1.2.23, MetaCyc:4.1.2.23-RXN] synonym: "2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:4.1.2.23] synonym: "2-keto-3-deoxyoctonic aldolase activity" EXACT [EC:4.1.2.23] synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)" EXACT [EC:4.1.2.23] synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase activity" EXACT [EC:4.1.2.23] synonym: "3-deoxy-D-manno-octulosonic aldolase activity" EXACT [EC:4.1.2.23] synonym: "3-deoxyoctulosonic aldolase activity" EXACT [EC:4.1.2.23] synonym: "KDOaldolase activity" EXACT [EC:4.1.2.23] xref: EC:4.1.2.23 xref: GO:0047439 xref: MetaCyc:4.1.2.23-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006748 name: 2-dehydro-3-deoxy-D-pentonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.28, MetaCyc:4.1.2.28-RXN] synonym: "2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.28] synonym: "2-keto-3-deoxy-D-pentonate aldolase activity" EXACT [EC:4.1.2.28] synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.28] xref: EC:4.1.2.28 xref: GO:0047440 xref: MetaCyc:4.1.2.28-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006749 name: 5-dehydro-2-deoxyphosphogluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydro-2-deoxy-D-gluconate 6-phosphate = malonate semialdehyde + dihydroxy-acetone-phosphate." [EC:4.1.2.29, MetaCyc:4.1.2.29-RXN] synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.29] synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity" EXACT [EC:4.1.2.29] synonym: "phospho-5-dehydro-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29] synonym: "phospho-5-keto-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29] xref: EC:4.1.2.29 xref: GO:0047441 xref: MetaCyc:4.1.2.29-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006750 name: 17-alpha-hydroxyprogesterone aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione." [EC:4.1.2.30, MetaCyc:4.1.2.30-RXN] synonym: "17-alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30] synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)" EXACT [EC:4.1.2.30] synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30] synonym: "17alpha-hydroxyprogesterone aldolase activity" EXACT [EC:4.1.2.30] synonym: "C-17/C-20 lyase activity" EXACT [EC:4.1.2.30] xref: EC:4.1.2.30 xref: GO:0047442 xref: MetaCyc:4.1.2.30-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006751 name: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate." [EC:4.1.3.17, MetaCyc:4.1.3.17-RXN] subset: gosubset_prok synonym: "4-hydroxy-4-methyl-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.17] synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.17] synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity" EXACT [EC:4.1.3.17] synonym: "gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity" EXACT [EC:4.1.3.17] synonym: "pyruvate aldolase activity" EXACT [EC:4.1.3.17] xref: EC:4.1.3.17 xref: GO:0047443 xref: MetaCyc:4.1.3.17-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0006752 name: N-acylneuraminate-9-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate." [EC:2.5.1.57, MetaCyc:4.1.3.20-RXN] synonym: "N-acetylneuraminate 9-phosphate lyase activity" EXACT [EC:2.5.1.57] synonym: "N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity" EXACT [EC:2.5.1.57] synonym: "N-acetylneuraminate 9-phosphate synthetase activity" EXACT [EC:2.5.1.57] synonym: "N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.57] synonym: "phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity" EXACT [EC:2.5.1.57] synonym: "sialic acid 9-phosphate synthetase activity" EXACT [EC:2.5.1.57] xref: EC:2.5.1.57 xref: GO:0047444 xref: MetaCyc:4.1.3.20-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0006753 name: 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = acetate + 7-methyl-3-oxooctanoyl-CoA." [EC:4.1.3.26, MetaCyc:4.1.3.26-RXN] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)" EXACT [EC:4.1.3.26] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity" EXACT [EC:4.1.3.26] synonym: "3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.26] synonym: "3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity" EXACT [EC:4.1.3.26] synonym: "beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity" EXACT [EC:4.1.3.26] synonym: "hydroxyisohexenylglutaryl-CoA:acetatelyase activity" EXACT [EC:4.1.3.26] xref: EC:4.1.3.26 xref: GO:0047445 xref: MetaCyc:4.1.3.26-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0006755 name: erythro-3-hydroxyaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid." [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN] synonym: "3-hydroxyaspartate dehydratase activity" BROAD [EC:4.3.1.20] synonym: "erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxyaspartate dehydratase activity" EXACT [] synonym: "erythro-beta-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.20] xref: EC:4.3.1.20 xref: GO:0047447 xref: MetaCyc:4.3.1.20-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0006756 name: 5-dehydro-4-deoxyglucarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 5-keto-4-deoxy-D-glucarate = CO2 + H2O + 2,5-dioxopentanoate." [EC:4.2.1.41, MetaCyc:4.2.1.41-RXN] subset: gosubset_prok synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.41] synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.41] synonym: "5-keto-4-deoxy-glucarate dehydratase activity" EXACT [EC:4.2.1.41] synonym: "D-4-deoxy-5-ketoglucarate hydro-lyase activity" EXACT [EC:4.2.1.41] synonym: "deoxyketoglucarate dehydratase activity" EXACT [EC:4.2.1.41] xref: EC:4.2.1.41 xref: GO:0047448 xref: MetaCyc:4.2.1.41-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006757 name: 2-dehydro-3-deoxy-L-arabinonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = H2O + 2,5-dioxopentanoate." [EC:4.2.1.43, MetaCyc:4.2.1.43-RXN] synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.43] synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.43] synonym: "2-keto-3-deoxy-L-arabinonate dehydratase activity" EXACT [EC:4.2.1.43] xref: EC:4.2.1.43 xref: GO:0047449 xref: MetaCyc:4.2.1.43-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006758 name: crotonoyl-[acyl-carrier-protein] hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]." [EC:4.2.1.58, MetaCyc:4.2.1.58-RXN] synonym: "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.58] synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.58] synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.58] synonym: "3-hydroxybutyryl acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.58] synonym: "beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" EXACT [EC:4.2.1.58] synonym: "beta-hydroxybutyryl acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.58] synonym: "crotonoyl-[acyl-carrier protein] hydratase activity" EXACT [] synonym: "crotonoyl-ACP hydratase activity" EXACT [] synonym: "crotonoyl-acyl-carrier-protein hydratase activity" EXACT [EC:4.2.1.58] synonym: "crotonyl acyl carrier protein hydratase activity" EXACT [EC:4.2.1.58] synonym: "enoyl acyl carrier protein hydrase activity" EXACT [EC:4.2.1.58] xref: EC:4.2.1.58 xref: GO:0047450 xref: MetaCyc:4.2.1.58-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006759 name: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN] synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.59] synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.59] synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.59] synonym: "3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxyoctanoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyoctanoyl thioester dehydratase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyoctanoyl-ACP-dehydrase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.59] xref: EC:4.2.1.59 xref: GO:0047451 xref: MetaCyc:4.2.1.59-RXN is_a: CCO:F0004104 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: CCO:F0006760 name: protoaphin-aglucone dehydratase (cyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin." [EC:4.2.1.73, MetaCyc:4.2.1.73-RXN] synonym: "protoaphin dehydratase (cyclizing)" EXACT [EC:4.2.1.73] synonym: "protoaphin dehydratase activity" EXACT [EC:4.2.1.73] synonym: "protoaphin-aglucone hydro-lyase (cyclizing)" EXACT [EC:4.2.1.73] synonym: "protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)" EXACT [EC:4.2.1.73] xref: EC:4.2.1.73 xref: GO:0047452 xref: MetaCyc:4.2.1.73-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006761 name: ATP-dependent NAD(P)H-hydrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide + ATP = phosphate + NADH + ADP." [EC:4.2.1.93, MetaCyc:4.2.1.93-RXN] synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)" EXACT [EC:4.2.1.93] synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.93] synonym: "ATP-dependent H(4)NAD(P)OH dehydratase activity" EXACT [] synonym: "ATP-dependent H4NAD(P)OH dehydratase activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" EXACT [EC:4.2.1.93] xref: EC:4.2.1.93 xref: GO:0047453 xref: MetaCyc:4.2.1.93-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006762 name: phaseollidin hydratase activity namespace: molecular_function def: "Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin." [EC:4.2.1.97, MetaCyc:4.2.1.97-RXN] synonym: "phaseollidin-hydrate hydro-lyase (phaseollidin-forming)" EXACT [EC:4.2.1.97] synonym: "phaseollidin-hydrate hydro-lyase activity" EXACT [EC:4.2.1.97] xref: EC:4.2.1.97 xref: GO:0047454 xref: MetaCyc:4.2.1.97-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006763 name: 16-alpha-hydroxyprogesterone dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone." [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN] synonym: "16-alpha-dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16-alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16-dehydroprogesterone hydratase activity" RELATED [] synonym: "16alpha-dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone dehydratase activity" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone hydro-lyase activity" EXACT [EC:4.2.1.98] synonym: "hydroxyprogesterone dehydroxylase activity" EXACT [] xref: EC:4.2.1.98 xref: GO:0047455 xref: GO:0047523 xref: MetaCyc:4.2.1.98-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006764 name: 2-methylisocitrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: methylisocitrate = H2O + 2-methylaconitate." [EC:4.2.1.99, MetaCyc:4.2.1.99-RXN] subset: gosubset_prok synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.99] synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.99] xref: EC:4.2.1.99 xref: GO:0047456 xref: MetaCyc:4.2.1.99-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006765 name: exo-(1,4)-alpha-D-glucan lyase activity namespace: molecular_function def: "Catalysis of the reaction: linear alpha-glucan = 1,5-anhydro-D-fructose + beta-D-glucose." [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN] synonym: "(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)" EXACT [EC:4.2.2.13] synonym: "alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13] synonym: "alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13] synonym: "alpha-1,4-glucan exo-lyase activity" EXACT [EC:4.2.2.13] synonym: "alpha-1,4-glucan lyase activity" BROAD [EC:4.2.2.13] synonym: "exo-(1->4)-alpha-D-glucan lyase activity" EXACT [EC:4.2.2.13] synonym: "exo-alpha-1,4-glucan lyase activity" EXACT [EC:4.2.2.13] xref: EC:4.2.2.13 xref: GO:0047457 xref: MetaCyc:4.2.2.13-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006766 name: beta-pyrazolylalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: pyrazole + O-acetyl-L-serine = acetate + 3-(pyrazol-1-yl)-L-alanine." [EC:2.5.1.51, MetaCyc:4.2.99.14-RXN] synonym: "3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51] synonym: "beta-(1-pyrazolyl)alanine synthase activity" EXACT [EC:2.5.1.51] synonym: "beta-pyrazolealanine synthase activity" EXACT [EC:2.5.1.51] synonym: "beta-pyrazolylalanine synthase (acetylserine) activity" EXACT [] synonym: "BPA-synthase activity" EXACT [EC:2.5.1.51] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity" EXACT [EC:2.5.1.51] synonym: "O3-acetyl-L-serine acetate-lyase (adding pyrazole)" EXACT [EC:2.5.1.51] synonym: "O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51] synonym: "pyrazolealanine synthase activity" EXACT [EC:2.5.1.51] synonym: "pyrazolylalaninase activity" EXACT [EC:2.5.1.51] xref: EC:2.5.1.51 xref: GO:0047458 xref: MetaCyc:4.2.99.14-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0006767 name: 3-aminobutyryl-CoA ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-3-aminobutyryl-CoA = NH3 + crotonyl-CoA." [EC:4.3.1.14, MetaCyc:4.3.1.14-RXN] synonym: "L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.3.1.14] synonym: "L-3-aminobutyryl-CoA ammonia-lyase activity" EXACT [EC:4.3.1.14] synonym: "L-3-aminobutyryl-CoA deaminase activity" EXACT [EC:4.3.1.14] xref: EC:4.3.1.14 xref: GO:0047459 xref: MetaCyc:4.3.1.14-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0006768 name: L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-2-amino-4-chloropent-4-enoate = NH3 + HCl + 2-oxopent-4-enoate." [EC:4.5.1.4, MetaCyc:4.5.1.4-RXN] synonym: "L-2-amino-4-chloro-4-pentenoate dehalogenase activity" EXACT [EC:4.5.1.4] synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)" EXACT [EC:4.5.1.4] synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)" EXACT [EC:4.5.1.4] xref: EC:4.5.1.4 xref: GO:0047460 xref: MetaCyc:4.5.1.4-RXN is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0006770 name: phenylalanine racemase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-phenylalanine + ATP = D-phenylalanine + pyrophosphate + AMP." [EC:5.1.1.11, MetaCyc:5.1.1.11-RXN] subset: gosubset_prok synonym: "gramicidin S synthetase I" RELATED [EC:5.1.1.11] synonym: "phenylalanine racemase (adenosine triphosphate-hydrolysing)" EXACT [EC:5.1.1.11] synonym: "phenylalanine racemase (ATP-hydrolysing)" BROAD [EC:5.1.1.11] synonym: "phenylalanine racemase activity" EXACT [EC:5.1.1.11] xref: EC:5.1.1.11 xref: GO:0047462 xref: MetaCyc:5.1.1.11-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0006771 name: 2-aminohexano-6-lactam racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-amino-hexano-6-lactam = D-2-amino-hexano-6-lactam." [EC:5.1.1.15, MetaCyc:5.1.1.15-RXN] synonym: "2-amino-hexano-6-lactam racemase activity" EXACT [EC:5.1.1.15] synonym: "alpha-amino-epsilon-caprolactam racemase activity" EXACT [EC:5.1.1.15] xref: EC:5.1.1.15 xref: GO:0047463 xref: MetaCyc:5.1.1.15-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0006772 name: heparosan-N-sulfate-glucuronate 5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN] synonym: "C-5 uronosyl epimerase activity" EXACT [EC:5.1.3.17] synonym: "D-glucuronyl C-5 epimerase activity" EXACT [EC:5.1.3.17] synonym: "heparosan epimerase activity" EXACT [EC:5.1.3.17] synonym: "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.17] synonym: "heparosan-N-sulphate-glucuronate 5-epimerase activity" EXACT [] synonym: "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity" EXACT [EC:5.1.3.17] synonym: "polyglucuronate epimerase activity" EXACT [EC:5.1.3.17] xref: EC:5.1.3.17 xref: GO:0047464 xref: MetaCyc:5.1.3.17-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0006773 name: N-acylglucosamine-6-phosphate 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate." [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN] subset: gosubset_prok synonym: "acylglucosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "acylglucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "acylmannosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "N-acetylglucosmamine 6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "N-acetylmannosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "N-acyl-D-glucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] xref: EC:5.1.3.9 xref: GO:0047465 xref: MetaCyc:5.1.3.9-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0006774 name: 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-chloro-4-carboxymmethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymmethylenebut-2-en-1,4-olide." [EC:5.2.1.10, MetaCyc:5.2.1.10-RXN] synonym: "2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity" EXACT [EC:5.2.1.10] synonym: "2-chlorocarboxymethylenebutenolide isomerase activity" EXACT [EC:5.2.1.-] synonym: "chlorodienelactone isomerase activity" EXACT [EC:5.2.1.-] xref: EC:5.2.1.- xref: EC:5.2.1.10 xref: GO:0018840 xref: GO:0047466 xref: MetaCyc:5.2.1.10-RXN xref: UM-BBD_enzymeID:e0232 is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0006775 name: 4-hydroxyphenylacetaldehyde-oxime isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime." [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN] xref: GO:0047467 xref: MetaCyc:5.2.1.11-RXN is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0006776 name: phosphoglucomutase (glucose-cofactor) activity namespace: molecular_function def: "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor." [EC:5.4.2.5, MetaCyc:5.4.2.5-RXN] synonym: "alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)" EXACT [EC:5.4.2.5] synonym: "glucose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.5] xref: EC:5.4.2.5 xref: GO:0047468 xref: MetaCyc:5.4.2.5-RXN is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0006777 name: 4-carboxymethyl-4-methylbutenolide mutase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide." [EC:5.4.99.14, MetaCyc:5.4.99.14-RXN] synonym: "4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity" EXACT [EC:5.4.99.14] synonym: "4-methyl-2-enelactone isomerase activity" EXACT [EC:5.4.99.14] synonym: "4-methyl-2-enelactone methyl-isomerase activity" EXACT [EC:5.4.99.14] synonym: "4-methyl-3-enelactone methyl isomerase activity" EXACT [EC:5.4.99.14] synonym: "4-methylmuconolactone methylisomerase activity" EXACT [EC:5.4.99.14] xref: EC:5.4.99.14 xref: GO:0047469 xref: MetaCyc:5.4.99.14-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0006779 name: maltose alpha-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: maltose = trehalose." [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN] subset: gosubset_prok synonym: "maltose alpha-D-glucosylmutase activity" EXACT [EC:5.4.99.16] synonym: "maltose glucosylmutase activity" EXACT [EC:5.4.99.16] synonym: "trehalose synthase activity" EXACT [EC:5.4.99.16] xref: EC:5.4.99.16 xref: GO:0047471 xref: MetaCyc:5.4.99.16-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0006780 name: 3-carboxy-cis,cis-muconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.2, MetaCyc:5.5.1.2-RXN] subset: gosubset_prok synonym: "2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.2] synonym: "3-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2] synonym: "3-carboxymuconolactone hydrolase activity" EXACT [EC:5.5.1.2] synonym: "beta-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2] synonym: "CMLE activity" EXACT [EC:5.5.1.2] xref: EC:5.5.1.2 xref: GO:0047472 xref: MetaCyc:5.5.1.2-RXN is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0006781 name: D-alanine-poly(phosphoribitol) ligase activity namespace: molecular_function def: "Catalysis of the reaction: poly(ribitol phosphate) + D-alanine + ATP = O-D-alanyl-poly(ribitol phosphate) + pyrophosphate + AMP." [EC:6.1.1.13, MetaCyc:6.1.1.13-RXN] subset: gosubset_prok synonym: "D-alanine-activating enzyme activity" RELATED [EC:6.1.1.13] synonym: "D-alanine-D-alanyl carrier protein ligase activity" EXACT [EC:6.1.1.13] synonym: "D-alanine-membrane acceptor ligase activity" EXACT [EC:6.1.1.13] synonym: "D-alanine: membrane acceptor ligase activity" EXACT [EC:6.1.1.13] synonym: "D-alanine:poly(phosphoribitol) ligase (AMP-forming)" EXACT [EC:6.1.1.13] synonym: "D-alanyl-poly(phosphoribitol) synthetase activity" EXACT [EC:6.1.1.13] xref: EC:6.1.1.13 xref: GO:0047473 xref: MetaCyc:6.1.1.13-RXN is_a: CCO:F0003435 ! ligase activity, forming aminoacyl-tRNA and related compounds [Term] id: CCO:F0006782 name: long-chain-fatty-acid-luciferin-component ligase activity namespace: molecular_function def: "Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + pyrophosphate + AMP." [EC:6.2.1.19, MetaCyc:6.2.1.19-RXN] subset: gosubset_prok synonym: "acyl-protein synthetase activity" RELATED [EC:6.2.1.19] synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" EXACT [EC:6.2.1.19] xref: EC:6.2.1.19 xref: GO:0047474 xref: MetaCyc:6.2.1.19-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0006783 name: phenylacetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + phenylacetate + ATP = phenylacetyl-CoA + products of ATP breakdown." [EC:6.2.1.30, MetaCyc:6.2.1.21-RXN] subset: gosubset_prok synonym: "PA-CoA ligase activity" EXACT [EC:6.2.1.30] synonym: "phenacyl coenzyme A synthetase activity" EXACT [EC:6.2.1.30] synonym: "phenylacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30] synonym: "phenylacetyl-CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30] synonym: "phenylacetyl-CoA ligase activity" EXACT [EC:6.2.1.30] xref: EC:6.2.1.30 xref: GO:0047475 xref: MetaCyc:PHENYLACETATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0006784 name: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + pyrophosphate + AMP." [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN] synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.28] synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.28] synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.28] synonym: "DHCA-CoA ligase activity" EXACT [EC:6.2.1.28] xref: EC:6.2.1.28 xref: GO:0047476 xref: MetaCyc:6.2.1.28-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0006785 name: aspartate-ammonia ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + L-aspartate + ATP = phosphate + L-asparagine + ADP." [EC:6.3.1.4, MetaCyc:6.3.1.4-RXN] synonym: "asparagine synthetase (adenosine diphosphate-forming)" EXACT [EC:6.3.1.4] synonym: "asparagine synthetase (ADP-forming) activity" EXACT [EC:6.3.1.4] synonym: "L-aspartate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.4] xref: EC:6.3.1.4 xref: GO:0047478 xref: MetaCyc:6.3.1.4-RXN is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0006786 name: trypanothione synthase activity namespace: molecular_function def: "Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate." [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN] synonym: "glutathionylspermidine:glutathione ligase (ADP-forming)" EXACT [EC:6.3.1.9] synonym: "TSR synthetase activity" EXACT [EC:6.3.1.9] xref: EC:6.3.1.9 xref: GO:0047479 xref: MetaCyc:6.3.1.9-RXN is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0006787 name: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP." [EC:6.3.2.10, MetaCyc:6.3.2.10-RXN] comment: Note that the enzyme UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase also has UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766). subset: gosubset_prok synonym: "MurF synthetase activity" RELATED [EC:6.3.2.10] synonym: "UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-MurNAc-pentapeptide synthetase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [] synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity" EXACT [] synonym: "UDPacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10] synonym: "uridine diphosphoacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10] xref: EC:6.3.2.10 xref: GO:0047480 xref: MetaCyc:6.3.2.10-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0006788 name: D-alanine-alanyl-poly(glycerolphosphate) ligase activity namespace: molecular_function def: "Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP." [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN] synonym: "D-alanine-membrane acceptor-ligase activity" EXACT [EC:6.3.2.16] synonym: "D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)" EXACT [EC:6.3.2.16] synonym: "D-alanine:membrane-acceptor ligase activity" EXACT [EC:6.3.2.16] synonym: "D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity" EXACT [EC:6.3.2.16] synonym: "D-alanyl-poly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16] synonym: "D-alanylalanylpoly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16] xref: EC:6.3.2.16 xref: GO:0047481 xref: MetaCyc:6.3.2.16-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0006789 name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine + ATP = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ADP." [EC:6.3.2.7, MetaCyc:6.3.2.7-RXN] subset: gosubset_prok synonym: "L-lysine-adding enzyme activity" RELATED [EC:6.3.2.7] synonym: "MurE synthetase activity" RELATED [EC:6.3.2.7] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.7] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity" EXACT [EC:6.3.2.7] synonym: "UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity" EXACT [EC:6.3.2.7] synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity" EXACT [EC:6.3.2.7] xref: EC:6.3.2.7 xref: GO:0047482 xref: MetaCyc:6.3.2.7-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0006790 name: imidazoleacetate-phosphoribosyldiphosphate ligase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phosphoribosyl diphosphate + imidazole-4-acetate + ATP = phosphate + pyrophosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + ADP." [EC:6.3.4.8, MetaCyc:6.3.4.8-RXN] synonym: "5-phosphoribosylimidazoleacetate synthetase activity" EXACT [EC:6.3.4.8] synonym: "imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)" EXACT [EC:6.3.4.8] xref: EC:6.3.4.8 xref: GO:0047483 xref: MetaCyc:6.3.4.8-RXN is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0006791 name: protein N-terminus binding namespace: molecular_function def: "Interacting selectively with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "N-terminal binding" EXACT [] xref: GO:0047485 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0006792 name: chondroitin ABC lyase activity namespace: molecular_function def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.4] subset: gosubset_prok xref: EC:4.2.2.4 xref: GO:0047486 xref: MetaCyc:4.2.2.4-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006793 name: oligogalacturonide lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(4-deoxy-beta-D-gluc-4-enuronosyl)-D-galacturonate = 25-dehydro-4-deoxy-D-glucuronate." [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN] subset: gosubset_prok synonym: "OGTE" RELATED [EC:4.2.2.6] synonym: "oligogalacturonate lyase activity" EXACT [EC:4.2.2.6] synonym: "unsaturated oligogalacturonate transeliminase activity" EXACT [EC:4.2.2.6] xref: EC:4.2.2.6 xref: GO:0047487 xref: MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006794 name: heparin lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN] subset: gosubset_prok synonym: "heparin eliminase activity" RELATED [EC:4.2.2.7] synonym: "heparinase activity" EXACT [EC:4.2.2.7] xref: EC:4.2.2.7 xref: GO:0047488 xref: MetaCyc:4.2.2.7-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006795 name: pectate disaccharide-lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of 4-(4-deoxy-a-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin." [EC:4.2.2.9] subset: gosubset_prok synonym: "(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity" EXACT [EC:4.2.2.9] synonym: "exo-PATE" RELATED [EC:4.2.2.9] synonym: "Exo-PATE activity" EXACT [EC:4.2.2.9] synonym: "exo-PGL" RELATED [EC:4.2.2.9] synonym: "Exo-PGL activity" EXACT [EC:4.2.2.9] synonym: "exopectate lyase activity" EXACT [EC:4.2.2.9] synonym: "exopectic acid transeliminase activity" EXACT [EC:4.2.2.9] synonym: "exopolygalacturonate lyase activity" EXACT [EC:4.2.2.9] synonym: "exopolygalacturonic acid-trans-eliminase activity" EXACT [EC:4.2.2.9] synonym: "PATE activity" EXACT [EC:4.2.2.9] synonym: "pectate exo-lyase activity" EXACT [EC:4.2.2.9] xref: EC:4.2.2.9 xref: GO:0047489 xref: MetaCyc:4.2.2.9-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006796 name: pectin lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of (14)-a-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-a-D-galact-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.10] subset: gosubset_prok synonym: "(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.10] synonym: "endo-pectin lyase activity" EXACT [EC:4.2.2.10] synonym: "pectin methyltranseliminase activity" EXACT [EC:4.2.2.10] synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.10] synonym: "pectolyase activity" EXACT [EC:4.2.2.10] synonym: "PL activity" EXACT [EC:4.2.2.10] synonym: "PMGL activity" EXACT [EC:4.2.2.10] synonym: "PNL activity" EXACT [EC:4.2.2.10] synonym: "polymethylgalacturonic transeliminase activity" EXACT [EC:4.2.2.10] xref: EC:4.2.2.10 xref: GO:0047490 xref: MetaCyc:4.2.2.10-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006797 name: poly(alpha-L-guluronate) lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.11] subset: gosubset_prok synonym: "alginase II activity" RELATED [EC:4.2.2.11] synonym: "guluronate lyase activity" EXACT [EC:4.2.2.11] synonym: "L-guluronan lyase activity" EXACT [EC:4.2.2.11] synonym: "L-guluronate lyase activity" EXACT [EC:4.2.2.11] synonym: "poly(alpha-L-1,4-guluronide) exo-lyase activity" EXACT [EC:4.2.2.11] synonym: "poly-alpha-L-guluronate lyase activity" EXACT [EC:4.2.2.11] synonym: "polyguluronate-specific alginate lyase activity" EXACT [EC:4.2.2.11] xref: EC:4.2.2.11 xref: GO:0047491 xref: MetaCyc:4.2.2.11-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006798 name: xanthan lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of the terminal b-D-mannosyl-b-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-a-L-threo-hex-4-enuronosyl group at the terminus of the side-chain." [EC:4.2.2.12] xref: EC:4.2.2.12 xref: GO:0047492 xref: MetaCyc:4.2.2.12-RXN is_a: CCO:F0003403 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: CCO:F0006799 name: ceramide cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + N-acylsphingosine = CMP + sphingomyelin." [EC:2.7.8.3] subset: gosubset_prok synonym: "CDP-choline:N-acylsphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.3] synonym: "phosphorylcholine-ceramide transferase activity" EXACT [EC:2.7.8.3] xref: EC:2.7.8.3 xref: GO:0047493 xref: MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006800 name: serine-phosphoethanolamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-ethanolamine + L-serine = CMP + L-serine-phosphoethanolamine." [EC:2.7.8.4] synonym: "CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity" EXACT [EC:2.7.8.4] synonym: "serine ethanolamine phosphate synthetase activity" EXACT [EC:2.7.8.4] synonym: "serine ethanolamine phosphodiester synthase activity" EXACT [EC:2.7.8.4] synonym: "serine ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.4] synonym: "serine-phosphinico-ethanolamine synthase activity" EXACT [EC:2.7.8.4] synonym: "serinephosphoethanolamine synthase activity" EXACT [EC:2.7.8.4] xref: EC:2.7.8.4 xref: GO:0047494 xref: MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006801 name: membrane-oligosaccharide glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another." [EC:2.7.8.21] synonym: "membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.21] synonym: "periplasmic phosphoglycerotransferase activity" NARROW [EC:2.7.8.21] synonym: "phosphoglycerol cyclase activity" RELATED [EC:2.7.8.21] xref: EC:2.7.8.21 xref: GO:0047495 xref: MetaCyc:2.7.8.21-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0006802 name: calcium-dependent phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate; requires Ca2+." [EC:3.1.1.4] synonym: "calcium-dependent cytosolic phospholipase A2 activity" NARROW [] synonym: "calcium-dependent secreted phospholipase A2 activity" NARROW [] xref: GO:0047498 is_a: CCO:F0001002 ! phospholipase A2 activity [Term] id: CCO:F0006803 name: calcium-independent phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate; does not require Ca2+." [EC:3.1.1.4] synonym: "calcium-independent cytosolic phospholipase A2 activity" NARROW [] xref: GO:0047499 is_a: CCO:F0001002 ! phospholipase A2 activity [Term] id: CCO:F0006817 name: 1,2-alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside." [EC:3.2.1.63, MetaCyc:1] synonym: "2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity" EXACT [EC:3.2.1.63] synonym: "almond emulsin fucosidase activity" EXACT [EC:3.2.1.63] synonym: "almond emulsin fucosidase II activity" NARROW [EC:3.2.1.63] synonym: "alpha-(1->2)-L-fucosidase activity" EXACT [EC:3.2.1.63] xref: EC:3.2.1.63 xref: GO:0047513 xref: MetaCyc:1 is_a: CCO:F0000945 ! alpha-L-fucosidase activity [Term] id: CCO:F0006818 name: 1,3-beta-D-glucan phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin." [EC:2.4.1.97, MetaCyc:1] synonym: "1,3-beta-D-glucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.97] synonym: "1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.97] synonym: "1,3-beta-glucan phosphorylase activity" EXACT [] synonym: "laminarin phosphorylase activity" RELATED [EC:2.4.1.97] synonym: "laminarin phosphoryltransferase activity" EXACT [EC:2.4.1.97] xref: EC:2.4.1.97 xref: GO:0047514 xref: MetaCyc:1 is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0006819 name: 1,3-beta-oligoglucan phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: oligomeric 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.30, MetaCyc:1] synonym: "1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.30] synonym: "beta-1,3-oligoglucan phosphorylase activity" EXACT [EC:2.4.1.30] synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" EXACT [EC:2.4.1.30] xref: EC:2.4.1.30 xref: GO:0047515 xref: MetaCyc:1 is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0006820 name: 1,3-propanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+." [EC:1.1.1.202, MetaCyc:1] subset: gosubset_prok synonym: "1,3-PD:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202] synonym: "1,3-propanediol oxidoreductase activity" EXACT [EC:1.1.1.202] synonym: "1,3-propanediol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202] synonym: "3-hydroxypropionaldehyde reductase activity" EXACT [EC:1.1.1.202] synonym: "propane-1,3-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.202] xref: EC:1.1.1.202 xref: GO:0047516 xref: MetaCyc:1 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006821 name: 1,4-beta-D-xylan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-xylose + 1,4-beta-D-xylan(n) = UDP + 1,4-beta-D-xylan(n+1)." [EC:2.4.2.24, MetaCyc:1] synonym: "1,4-beta-xylan synthase activity" EXACT [EC:2.4.2.24] synonym: "UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.24] synonym: "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity" EXACT [EC:2.4.2.24] synonym: "xylan synthase activity" EXACT [EC:2.4.2.24] synonym: "xylan synthetase activity" EXACT [EC:2.4.2.24] xref: EC:2.4.2.24 xref: GO:0047517 xref: MetaCyc:1 is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0006822 name: 1-methyladenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: 1-methyladenosine + H2O = 1-methyladenine + D-ribose." [EC:3.2.2.13, MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN] synonym: "1-methyladenosine hydrolase activity" EXACT [EC:3.2.2.13] synonym: "1-methyladenosine ribohydrolase activity" EXACT [EC:3.2.2.13] xref: EC:3.2.2.13 xref: GO:0047518 xref: MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0006823 name: quinate dehydrogenase (pyrroloquinoline-quinone) activity namespace: molecular_function def: "Catalysis of the reaction: quinate + pyrroloquinoline-quinone = 5-dehydroquinate + reduced pyrroloquinoline-quinone." [EC:1.1.99.25, MetaCyc:1.1.99.25-RXN] subset: gosubset_prok synonym: "NAD(P)-independent quinate dehydrogenase activity" EXACT [EC:1.1.99.25] synonym: "quinate:pyrroloquinoline-quinone 3-oxidoreductase activity" EXACT [EC:1.1.99.25] synonym: "quinate:pyrroloquinoline-quinone 5-oxidoreductase activity" EXACT [EC:1.1.99.25] xref: EC:1.1.99.25 xref: GO:0047519 xref: MetaCyc:1.1.99.25-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0006824 name: 11-cis-retinyl-palmitate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 11-cis-retinyl palmitate + H2O = 11-cis-retinol + palmitate." [EC:3.1.1.63, MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN] synonym: "11-cis-retinol palmitate esterase activity" EXACT [EC:3.1.1.63] synonym: "11-cis-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.63] synonym: "RPH" RELATED [EC:3.1.1.63] xref: EC:3.1.1.63 xref: GO:0047520 xref: MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006825 name: 12-beta-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-alpha,7-alpha,12-beta-trihydroxy-5-beta-cholanate + NADP+ = 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate + NADPH + H+." [EC:1.1.1.238, MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN] synonym: "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.238] synonym: "12beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.238] synonym: "12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" EXACT [EC:1.1.1.238] xref: EC:1.1.1.238 xref: GO:0047521 xref: MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006826 name: 15-oxoprostaglandin 13-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN] synonym: "(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity" EXACT [EC:1.3.1.48] synonym: "15-ketoprostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48] synonym: "15-oxo-delta13-prostaglandin reductase activity" EXACT [EC:1.3.1.48] synonym: "15-oxoprostaglandin 13-reductase activity" EXACT [] synonym: "delta13-15-ketoprostaglandin reductase activity" EXACT [EC:1.3.1.48] synonym: "prostaglandin 13-reductase activity" EXACT [EC:1.3.1.48] synonym: "prostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48] xref: EC:1.3.1.48 xref: GO:0047522 xref: MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006827 name: 16-hydroxysteroid epimerase activity namespace: molecular_function def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid." [EC:5.1.99.2, MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN] synonym: "16-hydroxysteroid 16-epimerase activity" EXACT [EC:5.1.99.2] xref: EC:5.1.99.2 xref: GO:0047524 xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN is_a: CCO:F0003417 ! racemase and epimerase activity [Term] id: CCO:F0006828 name: 2'-hydroxydaidzein reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzen + NADPH + H+." [EC:1.3.1.51, MetaCyc:2] synonym: "2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] synonym: "2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] synonym: "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] synonym: "HDR activity" EXACT [EC:1.3.1.51] synonym: "NADPH:2'-hydroxydaidzein oxidoreductase activity" EXACT [EC:1.3.1.51] xref: EC:1.3.1.51 xref: GO:0047525 xref: MetaCyc:2 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006829 name: 2'-hydroxyisoflavone reductase activity namespace: molecular_function def: "Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+." [EC:1.3.1.45, MetaCyc:2] subset: gosubset_prok synonym: "2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity" EXACT [EC:1.3.1.45] synonym: "isoflavone reductase activity" EXACT [EC:1.3.1.45] synonym: "NADPH:2'-hydroxyisoflavone oxidoreductase activity" EXACT [EC:1.3.1.45] synonym: "vestitone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.45] xref: EC:1.3.1.45 xref: GO:0047526 xref: MetaCyc:2 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006830 name: 2,3-dihydroxybenzoate-serine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine." [EC:6.3.2.14, MetaCyc:1] synonym: "2,3-dihydroxybenzoate:L-serine ligase activity" EXACT [EC:6.3.2.14] synonym: "2,3-dihydroxybenzoylserine synthetase activity" EXACT [EC:6.3.2.14] synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" EXACT [EC:6.3.2.14] xref: EC:6.3.2.14 xref: GO:0047527 xref: MetaCyc:2 is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0006831 name: 2,3-dihydroxyindole 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxyindole + O2 = anthranilate + CO2." [EC:1.13.11.23, MetaCyc:2] synonym: "2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity" EXACT [EC:1.13.11.23] xref: EC:1.13.11.23 xref: GO:0047528 xref: MetaCyc:2 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006832 name: 2,3-dimethylmalate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dimethylmalate = propanoate + pyruvate." [EC:4.1.3.32, MetaCyc:2] synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)" EXACT [EC:4.1.3.32] synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32] synonym: "2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32] xref: EC:4.1.3.32 xref: GO:0047529 xref: MetaCyc:2 is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0006833 name: 2,4-diaminopentanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+." [EC:1.4.1.12, MetaCyc:2] synonym: "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.12] synonym: "2,4-diaminopentanoic acid C4 dehydrogenase activity" EXACT [EC:1.4.1.12] xref: EC:1.4.1.12 xref: GO:0047530 xref: MetaCyc:2 is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006834 name: 2,5-diaminovalerate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-diaminopentanoate + 2-oxoglutarate = 5-amino-2-oxopentanoate + L-glutamate." [EC:2.6.1.8, MetaCyc:2] synonym: "2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.8] synonym: "2,5-diaminovalerate aminotransferase activity" EXACT [] synonym: "diamino acid aminotransferase activity" EXACT [EC:2.6.1.8] synonym: "diamino-acid aminotransferase activity" RELATED [EC:2.6.1.8] synonym: "diamino-acid transaminase activity" EXACT [EC:2.6.1.8] xref: EC:2.6.1.8 xref: GO:0047531 xref: MetaCyc:2 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006835 name: 2,5-dioxopiperazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine." [EC:3.5.2.13, MetaCyc:2] synonym: "2,5-dioxopiperazine amidohydrolase activity" EXACT [EC:3.5.2.13] synonym: "cyclo(Gly-Gly) hydrolase activity" EXACT [EC:3.5.2.13] synonym: "cyclo(glycylglycine) hydrolase activity" EXACT [EC:3.5.2.13] xref: EC:3.5.2.13 xref: GO:0047532 xref: MetaCyc:2 is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0006836 name: 2,5-dioxovalerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+." [EC:1.2.1.26, MetaCyc:2] synonym: "2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity" EXACT [EC:1.2.1.26] synonym: "2-oxoglutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26] synonym: "alpha-ketoglutaric semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26] xref: EC:1.2.1.26 xref: GO:0047533 xref: MetaCyc:2 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006837 name: 2-acetolactate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate." [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN] synonym: "2-acetolactate methylmutase activity" EXACT [EC:5.4.99.3] synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3] synonym: "acetolactate mutase activity" EXACT [EC:5.4.99.3] xref: EC:5.4.99.3 xref: GO:0047534 xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0006838 name: 2-alkyn-1-ol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + NADH + H+." [EC:1.1.1.165, MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN] synonym: "2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.165] xref: EC:1.1.1.165 xref: GO:0047535 xref: MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006839 name: 2-aminoadipate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN] synonym: "2-aminoadipate aminotransferase activity" EXACT [] synonym: "2-aminoadipic aminotransferase activity" EXACT [EC:2.6.1.39] synonym: "alpha-aminoadipate aminotransferase activity" EXACT [EC:2.6.1.39] synonym: "glutamate-alpha-ketoadipate transaminase activity" EXACT [EC:2.6.1.39] synonym: "glutamic-ketoadipic transaminase activity" EXACT [EC:2.6.1.39] synonym: "L-2-aminoadipate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.39] xref: EC:2.6.1.39 xref: GO:0047536 xref: MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006840 name: 2-aminohexanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate." [EC:2.6.1.67, MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN] synonym: "2-aminohexanoate aminotransferase activity" EXACT [] synonym: "L-2-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "leucine L-norleucine: 2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "norleucine (leucine) aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "norleucine aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "norleucine transaminase activity" EXACT [EC:2.6.1.67] xref: EC:2.6.1.67 xref: GO:0047537 xref: MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006841 name: 2-carboxy-D-arabinitol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate." [EC:3.1.3.63, MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN] synonym: "2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.63] synonym: "2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.63] synonym: "2-carboxyarabinitol 1-phosphatase activity" EXACT [EC:3.1.3.63] xref: EC:3.1.3.63 xref: GO:0047538 xref: MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0006842 name: 2-deoxyglucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol." [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN] synonym: "2-deoxy-alpha-D-glucosidase activity" EXACT [EC:3.2.1.112] synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" EXACT [EC:3.2.1.112] synonym: "2-deoxy-alpha-glucosidase activity" EXACT [EC:3.2.1.112] xref: EC:3.2.1.112 xref: GO:0047539 xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006843 name: 2-enoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+." [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN] subset: gosubset_prok synonym: "butanoate:NAD+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.31] synonym: "enoate reductase activity" EXACT [EC:1.3.1.31] xref: EC:1.3.1.31 xref: GO:0047540 xref: MetaCyc:2-ENOATE-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006844 name: 2-furoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-furoate + CoA = AMP + diphosphate + 2-furoyl-CoA." [EC:6.2.1.31, MetaCyc:2-FUROATE--COA-LIGASE-RXN] synonym: "2-furoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.31] synonym: "2-furoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.31] xref: EC:6.2.1.31 xref: GO:0047541 xref: MetaCyc:2-FUROATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0006845 name: 2-furoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor." [EC:1.3.99.8, MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN] synonym: "2-furoyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.8] synonym: "2-furoyl coenzyme A hydroxylase activity" EXACT [EC:1.3.99.8] synonym: "2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8] synonym: "2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8] synonym: "furoyl-CoA hydroxylase activity" EXACT [EC:1.3.99.8] xref: EC:1.3.99.8 xref: GO:0047542 xref: MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0006846 name: 2-hexadecenal reductase activity namespace: molecular_function def: "Catalysis of the reaction: hexadecanal + NADP+ = 2-trans-hexadecenal + NADPH + H+." [EC:1.3.1.27, MetaCyc:2-HEXADECENAL-REDUCTASE-RXN] synonym: "hexadecanal: NADP+ oxidoreductase activity" EXACT [EC:1.3.1.27] synonym: "hexadecanal:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.27] xref: EC:1.3.1.27 xref: GO:0047543 xref: MetaCyc:2-HEXADECENAL-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006847 name: 2-hydroxybiphenyl 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxybiphenyl + NADH + H+ + O2 = 2,3-dihydroxybiphenyl + NAD+ + H2O." [EC:1.14.13.44, MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN] synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.44] xref: EC:1.14.13.44 xref: GO:0047544 xref: MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006848 name: 2-hydroxyglutarate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.2] synonym: "(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.2] synonym: "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)" NARROW [EC:1.1.99.2] synonym: "alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2] synonym: "alpha-hydroxyglutarate oxidoreductase activity" EXACT [EC:1.1.99.2] synonym: "alpha-ketoglutarate reductase activity" EXACT [EC:1.1.99.2] synonym: "hydroxyglutaric dehydrogenase activity" EXACT [EC:1.1.99.2] synonym: "L-alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2] synonym: "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase" NARROW [EC:1.1.99.2] xref: EC:1.1.99.2 xref: GO:0047545 xref: MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0006849 name: 2-hydroxypyridine 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxypyridine + donor-H2 + O2 = 2,5-dihydroxypyridine + acceptor + H2O." [EC:1.14.99.26, MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN] synonym: "2-hydroxypyridine oxygenase activity" EXACT [EC:1.14.99.26] synonym: "2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.99.26] xref: EC:1.14.99.26 xref: GO:0047546 xref: MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0006850 name: 2-methylcitrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O." [EC:4.2.1.79, MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN] subset: gosubset_prok synonym: "(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.79] synonym: "2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.79] synonym: "2-methylcitrate hydro-lyase activity" EXACT [EC:4.2.1.79] synonym: "prpD" RELATED [EC:4.2.1.79] xref: EC:4.2.1.79 xref: GO:0047547 xref: MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006851 name: 2-methyleneglutarate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate." [EC:5.4.99.4, MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN] subset: gosubset_prok synonym: "2-methyleneglutarate carboxy-methylenemethylmutase activity" EXACT [EC:5.4.99.4] synonym: "alpha-methyleneglutarate mutase activity" EXACT [EC:5.4.99.4] xref: EC:5.4.99.4 xref: GO:0047548 xref: MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0006852 name: 2-nitrophenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-nitrophenol + NADPH + H+ + O2 = catechol + NO2(-) (nitrite) + NADP+ + H2O." [EC:1.14.13.31, MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN] synonym: "2-nitrophenol oxygenase activity" EXACT [EC:1.14.13.31] synonym: "2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)" EXACT [EC:1.14.13.31] synonym: "nitrophenol oxygenase activity" BROAD [EC:1.14.13.31] xref: EC:1.14.13.31 xref: GO:0047549 xref: MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006853 name: 2-oxoadipate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + NADH + H+." [EC:1.1.1.172, MetaCyc:2-OXOADIPATE-REDUCTASE-RXN] synonym: "2-hydroxyadipate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.172] synonym: "2-ketoadipate reductase activity" EXACT [EC:1.1.1.172] synonym: "alpha-ketoadipate reductase activity" EXACT [EC:1.1.1.172] xref: EC:1.1.1.172 xref: GO:0047550 xref: MetaCyc:2-OXOADIPATE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006854 name: 2-oxoaldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+." [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-(NAD+)-RXN] synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.23] synonym: "2-oxoaldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.23] synonym: "2-oxoaldehyde:NAD+ 2-oxidoreductase activity" EXACT [EC:1.2.1.23] synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.23] synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.23] synonym: "NAD-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23] synonym: "NAD-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23] xref: EC:1.2.1.23 xref: GO:0047551 xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-(NAD+)-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006855 name: 2-oxoaldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+." [EC:1.2.1.49, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-(NADP+)-RXN] synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.49] synonym: "2-oxoaldehyde:NADP+ 2-oxidoreductase activity" EXACT [EC:1.2.1.49] synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.49] synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.49] synonym: "NADP-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49] synonym: "NADP-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49] xref: EC:1.2.1.49 xref: GO:0047552 xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006856 name: 2-oxoglutarate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN] subset: gosubset_prok synonym: "2-ketoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "alpha-ketoglutarate synthase activity" EXACT [EC:1.2.7.3] synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "KGOR activity" EXACT [EC:1.2.7.3] xref: EC:1.2.7.3 xref: GO:0047553 xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN is_a: CCO:F0003227 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0006857 name: 2-pyrone-4,6-dicarboxylate lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 2-pyrone-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate." [EC:3.1.1.57, MetaCyc:2-PYRONE-4] subset: gosubset_prok synonym: "2-pyrone-4,6-dicarboxylate lactonohydrolase activity" EXACT [EC:3.1.1.57] xref: EC:3.1.1.57 xref: GO:0047554 xref: MetaCyc:2-PYRONE-4 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006858 name: 3',5'-cyclic-GMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate." [EC:3.1.4.35, MetaCyc:3] synonym: "3',5' cyclic-GMP phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.35] synonym: "cGMP phosphodiesterase activity" EXACT [] synonym: "cGMP-PDE" RELATED [EC:3.1.4.35] synonym: "cGMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic 3',5'-GMP phosphodiesterase activity" EXACT [EC:3.1.4.35] synonym: "cyclic GMP phosphodiesterase activity" EXACT [] synonym: "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.35] synonym: "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.35] synonym: "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT [] xref: EC:3.1.4.35 xref: GO:0004116 xref: GO:0047555 xref: MetaCyc:3 is_a: CCO:F0000586 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: CCO:F0006859 name: 3,4-dihydroxyphthalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.69] synonym: "3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.69] synonym: "3,4-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.69] xref: EC:4.1.1.69 xref: GO:0047556 xref: MetaCyc:3 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006860 name: 3-aci-nitropropanoate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + O2 + 3-aci-nitropropanoate = NO2(-) (nitrite) + H2O2 + 3-oxopropanoate." [EC:1.7.3.5, MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN] synonym: "3-aci-nitropropanoate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.5] synonym: "propionate-3-nitronate oxidase activity" EXACT [EC:1.7.3.5] xref: EC:1.7.3.5 xref: GO:0047557 xref: MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN is_a: CCO:F0003258 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: CCO:F0006861 name: 3-cyanoalanine hydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine = 3-cyanoalanine + H2O." [EC:4.2.1.65, MetaCyc:3-CYANOALANINE-HYDRATASE-RXN] synonym: "beta-CNA nitrilase activity" EXACT [EC:4.2.1.65] synonym: "beta-CNAla hydrolase activity" EXACT [EC:4.2.1.65] synonym: "beta-cyanoalanine hydratase activity" EXACT [EC:4.2.1.65] synonym: "beta-cyanoalanine hydrolase activity" EXACT [EC:4.2.1.65] synonym: "L-asparagine hydro-lyase (3-cyanoalanine-forming)" EXACT [EC:4.2.1.65] synonym: "L-asparagine hydro-lyase activity" EXACT [EC:4.2.1.65] xref: EC:4.2.1.65 xref: GO:0047558 xref: MetaCyc:3-CYANOALANINE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006862 name: 3-dehydro-L-gulonate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+." [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN] synonym: "2,3-diketo-L-gulonate reductase activity" EXACT [EC:1.1.1.130] synonym: "3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.130] synonym: "3-keto-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.130] synonym: "3-ketogulonate dehydrogenase activity" EXACT [EC:1.1.1.130] xref: EC:1.1.1.130 xref: GO:0047559 xref: MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006863 name: 3-dehydrosphinganine reductase activity namespace: molecular_function def: "Catalysis of the reaction: sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+." [EC:1.1.1.102, MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN] synonym: "3-ketosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "3-oxosphinganine:NADPH oxidoreductase activity" EXACT [EC:1.1.1.102] synonym: "D-3-dehydrosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "D-3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "D-3-oxosphinganine:B-NADPH oxidoreductase activity" EXACT [EC:1.1.1.102] synonym: "D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.102] synonym: "DSR activity" EXACT [EC:1.1.1.102] synonym: "KTS reductase activity" RELATED [EC:1.1.1.102] xref: EC:1.1.1.102 xref: GO:0047560 xref: MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006864 name: 3-hydroxyanthranilate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2." [EC:1.10.3.5, MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN] synonym: "3-hydroxyanthranilate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.5] synonym: "3-hydroxyanthranilic acid oxidase activity" EXACT [EC:1.10.3.5] xref: EC:1.10.3.5 xref: GO:0047561 xref: MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN is_a: CCO:F0003273 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: CCO:F0006865 name: 3-hydroxyaspartate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = glycine + glyoxylate." [EC:4.1.3.14, MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN] synonym: "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14] synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)" EXACT [EC:4.1.3.14] synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14] synonym: "erythro-beta-hydroxyaspartate aldolase activity" EXACT [EC:4.1.3.14] synonym: "erythro-beta-hydroxyaspartate glycine-lyase activity" EXACT [EC:4.1.3.14] xref: EC:4.1.3.14 xref: GO:0047562 xref: MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0006866 name: 3-hydroxybenzoate 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + donor-H2 + O2 = 2,3-dihydroxybenzoate + acceptor + H2O." [EC:1.14.99.23, MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN] synonym: "3-HBA-2-hydroxylase activity" EXACT [EC:1.14.99.23] synonym: "3-hydroxybenzoate 2-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.23] xref: EC:1.14.99.23 xref: GO:0047563 xref: MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0006867 name: 3-hydroxycyclohexanone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxycyclohexanone + acceptor = cyclohexane-1,3-dione + reduced acceptor." [EC:1.1.99.26, MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN] synonym: "3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.26] xref: EC:1.1.99.26 xref: GO:0047564 xref: MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0006868 name: 3-hydroxypropionate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + NADH + H+." [EC:1.1.1.59, MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN] synonym: "3-hydroxypropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.59] xref: EC:1.1.1.59 xref: GO:0047565 xref: MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006869 name: 3-ketovalidoxylamine C-N-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one." [EC:4.3.3.1, MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN] synonym: "3-ketovalidoxylamine A C-N-lyase activity" EXACT [EC:4.3.3.1] synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]" RELATED [EC:4.3.3.1] synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity" EXACT [EC:4.3.3.1] synonym: "p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity" EXACT [EC:4.3.3.1] xref: EC:4.3.3.1 xref: GO:0047566 xref: MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN is_a: CCO:F0003408 ! amine-lyase activity [Term] id: CCO:F0006870 name: 3-methyleneoxindole reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyloxindole + NADP+ = 3-methyleneoxindole + NADPH + H+." [EC:1.3.1.17, MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN] synonym: "3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17] synonym: "3-methyloxindole:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17] xref: EC:1.3.1.17 xref: GO:0047567 xref: MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006871 name: 3-oxo-5-beta-steroid 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor." [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN] synonym: "3-oxo-5beta-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.6] synonym: "3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.6] synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.6] synonym: "delta4-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.99.6] xref: EC:1.3.99.6 xref: GO:0047568 xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN is_a: CCO:F0005255 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: CCO:F0006872 name: 3-oxoadipate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA." [EC:2.8.3.6, MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN] subset: gosubset_prok synonym: "3-oxoadipate coenzyme A-transferase activity" EXACT [EC:2.8.3.6] synonym: "3-oxoadipate succinyl-CoA transferase activity" EXACT [EC:2.8.3.6] synonym: "beta-ketoadipate:succinyl-CoA transferase activity" EXACT [EC:2.8.3.6] synonym: "succinyl-CoA:3-oxoadipate CoA-transferase activity" EXACT [EC:2.8.3.6] xref: EC:2.8.3.6 xref: GO:0047569 xref: MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0006873 name: 3-oxoadipate enol-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate." [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN] subset: gosubset_prok synonym: "3-ketoadipate enol-lactonase activity" EXACT [EC:3.1.1.24] synonym: "3-oxoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] synonym: "4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity" EXACT [EC:3.1.1.24] synonym: "beta-ketoadipate enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] synonym: "beta-ketoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] synonym: "carboxymethylbutenolide lactonase activity" EXACT [EC:3.1.1.24] xref: EC:3.1.1.24 xref: GO:0047570 xref: MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006874 name: 3-oxosteroid 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor." [EC:1.3.99.4, MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "1-ene-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-ketosteroid-1-en-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-ketosteroid-delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid:(acceptor) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid:acceptor delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] synonym: "4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity" EXACT [EC:1.3.99.4] synonym: "delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "delta1-steroid reductase activity" EXACT [EC:1.3.99.4] xref: EC:1.3.99.4 xref: GO:0047571 xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN is_a: CCO:F0005255 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: CCO:F0006875 name: 3-phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate 3-phosphate + H2O = D-glycerate + phosphate." [EC:3.1.3.38, MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN] synonym: "3-PGA phosphatase activity" EXACT [EC:3.1.3.38] synonym: "D-3-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.38] synonym: "D-glycerate-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.38] xref: EC:3.1.3.38 xref: GO:0047572 xref: MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0006876 name: 4-acetamidobutyrate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate." [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN] synonym: "4-acetamidobutanoate amidohydrolase activity" EXACT [EC:3.5.1.63] xref: EC:3.5.1.63 xref: GO:0047573 xref: MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006877 name: 4-acetamidobutyryl-CoA deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-acetamidobutanoyl + H2O = acetate + 4-aminobutanoyl-CoA." [EC:3.5.1.51, MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN] synonym: "4-acetamidobutanoyl-CoA amidohydrolase activity" EXACT [EC:3.5.1.51] synonym: "aminobutyryl-CoA thiolesterase activity" EXACT [EC:3.5.1.51] synonym: "deacetylase-thiolesterase activity" EXACT [EC:3.5.1.51] xref: EC:3.5.1.51 xref: GO:0047574 xref: MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006878 name: 4-carboxymuconolactone decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2." [EC:4.1.1.44, MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "4-carboxymonolactone carboxy-lyase activity" EXACT [EC:4.1.1.44] synonym: "4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)" EXACT [EC:4.1.1.44] synonym: "4-carboxymuconolactone carboxy-lyase activity" EXACT [EC:4.1.1.44] synonym: "gamma-4-carboxymuconolactone decarboxylase activity" EXACT [EC:4.1.1.44] xref: EC:4.1.1.44 xref: GO:0047575 xref: MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006879 name: 4-chlorobenzoate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride." [EC:3.8.1.6, MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN] synonym: "4-chlorobenzoate chlorohydrolase activity" EXACT [EC:3.8.1.6] synonym: "halobenzoate dehalogenase activity" EXACT [EC:3.8.1.6] xref: EC:3.8.1.6 xref: GO:0047576 xref: MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0006880 name: 4-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH + H+." [EC:1.1.1.61, MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "4-hydroxybutanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.61] synonym: "gamma-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.61] xref: EC:1.1.1.61 xref: GO:0047577 xref: MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006881 name: 4-hydroxyglutamate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate." [EC:2.6.1.23, MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN] synonym: "4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.23] synonym: "4-hydroxyglutamate aminotransferase activity" EXACT [] xref: EC:2.6.1.23 xref: GO:0047578 xref: MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006882 name: 4-hydroxymandelate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2." [EC:1.1.3.19, MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN] synonym: "(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.19] synonym: "L-4-hydroxymandelate oxidase (decarboxylating)" EXACT [EC:1.1.3.19] xref: EC:1.1.3.19 xref: GO:0047579 xref: MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0006883 name: 4-hydroxyproline epimerase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline." [EC:5.1.1.8, MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN] synonym: "4-hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8] synonym: "hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8] synonym: "hydroxyproline epimerase activity" EXACT [EC:5.1.1.8] synonym: "L-hydroxyproline epimerase activity" EXACT [EC:5.1.1.8] xref: EC:5.1.1.8 xref: GO:0047580 xref: MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0006884 name: 4-methyleneglutamate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-methylene-L-glutamate + NH3 = AMP + diphosphate + 4-methylene-L-glutamine." [EC:6.3.1.7, MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN] subset: gosubset_prok synonym: "4-methylene-L-glutamate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.7] synonym: "4-methyleneglutamine synthetase activity" EXACT [EC:6.3.1.7] xref: EC:6.3.1.7 xref: GO:0047581 xref: MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0006885 name: 4-methyleneglutaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH3." [EC:3.5.1.67, MetaCyc:4-METHYLENEGLUTAMINASE-RXN] synonym: "4-methylene-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.67] synonym: "4-methyleneglutamine amidohydrolase activity" EXACT [EC:3.5.1.67] synonym: "4-methyleneglutamine deamidase activity" EXACT [EC:3.5.1.67] xref: EC:3.5.1.67 xref: GO:0047582 xref: MetaCyc:4-METHYLENEGLUTAMINASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006886 name: 4-methyloxaloacetate esterase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate 4-methyl ester + H2O = oxaloacetate + methanol." [EC:3.1.1.44, MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN] synonym: "oxaloacetate-4-methyl-ester oxaloacetohydrolase activity" EXACT [EC:3.1.1.44] xref: EC:3.1.1.44 xref: GO:0047583 xref: MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006887 name: 4-oxalmesaconate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O." [EC:4.2.1.83, MetaCyc:4-OXALMESACONATE-HYDRATASE-RXN] subset: gosubset_prok synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.83] synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83] synonym: "4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83] synonym: "4-carboxy-2-oxohexenedioate hydratase activity" EXACT [EC:4.2.1.83] synonym: "gamma-oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83] synonym: "oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83] xref: EC:4.2.1.83 xref: GO:0047584 xref: MetaCyc:4-OXALMESACONATE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006888 name: 4-pyridoxolactonase activity namespace: molecular_function def: "Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate." [EC:3.1.1.27, MetaCyc:4-PYRIDOXOLACTONASE-RXN] synonym: "4-pyridoxolactone lactonohydrolase activity" EXACT [EC:3.1.1.27] xref: EC:3.1.1.27 xref: GO:0047585 xref: MetaCyc:4-PYRIDOXOLACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006889 name: 5'-acylphosphoadenosine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate." [EC:3.6.1.20, MetaCyc:5] synonym: "5'-acylphosphoadenosine acylhydrolase activity" EXACT [EC:3.6.1.20] synonym: "5-phosphoadenosine hydrolase activity" EXACT [EC:3.6.1.20] xref: EC:3.6.1.20 xref: GO:0047586 xref: MetaCyc:5 is_a: CCO:F0003386 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: CCO:F0006890 name: 5-alpha-hydroxysteroid dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-ergosta-7,22-diene-3-beta,5-diol = ergosterol + H2O." [EC:4.2.1.62, MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN] synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)" EXACT [EC:4.2.1.62] synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity" EXACT [EC:4.2.1.62] synonym: "5alpha-hydroxysteroid dehydratase activity" EXACT [EC:4.2.1.62] xref: EC:4.2.1.62 xref: GO:0047587 xref: MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006891 name: 5-aminopentanamidase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3." [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN] synonym: "5-aminonorvaleramidase activity" EXACT [EC:3.5.1.30] synonym: "5-aminopentanamide amidohydrolase activity" EXACT [EC:3.5.1.30] synonym: "5-aminovaleramidase activity" EXACT [EC:3.5.1.30] xref: EC:3.5.1.30 xref: GO:0047588 xref: MetaCyc:5-AMINOPENTANAMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006892 name: 5-aminovalerate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate." [EC:2.6.1.48, MetaCyc:5-AMINOVALERATE-AMINOTRANSFERASE-RXN] synonym: "5-aminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.48] synonym: "5-aminovalerate aminotransferase activity" EXACT [] synonym: "delta-aminovalerate aminotransferase activity" EXACT [EC:2.6.1.48] synonym: "delta-aminovalerate transaminase activity" EXACT [EC:2.6.1.48] xref: EC:2.6.1.48 xref: GO:0047589 xref: MetaCyc:5-AMINOVALERATE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006893 name: 5-dehydro-2-deoxygluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate." [EC:2.7.1.92, MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN] subset: gosubset_prok synonym: "5-keto-2-deoxyglucono kinase (phosphorylating)" EXACT [EC:2.7.1.92] synonym: "5-keto-2-deoxygluconokinase activity" EXACT [EC:2.7.1.92] synonym: "ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.92] synonym: "DKH kinase activity" EXACT [EC:2.7.1.92] xref: EC:2.7.1.92 xref: GO:0047590 xref: MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006894 name: 5-hydroxypentanoate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 5-hydroxypentanoate = acetate + 5-hydroxy-pentanoyl-CoA." [EC:2.8.3.14, MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN] synonym: "5-hydroxyvalerate CoA-transferase activity" EXACT [EC:2.8.3.14] synonym: "5-hydroxyvalerate coenzyme A transferase activity" EXACT [EC:2.8.3.14] synonym: "acetyl-CoA:5-hydroxypentanoate CoA-transferase activity" EXACT [EC:2.8.3.14] xref: EC:2.8.3.14 xref: GO:0047591 xref: MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0006895 name: 5-pyridoxate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+." [EC:1.14.12.5, MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN] synonym: "5-pyridoxate oxidase activity" EXACT [EC:1.14.12.5] synonym: "5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.5] xref: EC:1.14.12.5 xref: GO:0047592 xref: MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN is_a: CCO:F0003291 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: CCO:F0006896 name: 6-acetylglucose deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate." [EC:3.1.1.33, MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN] synonym: "6-acetyl-D-glucose acetylhydrolase activity" EXACT [EC:3.1.1.33] synonym: "6-O-acetylglucose deacetylase activity" EXACT [EC:3.1.1.33] xref: EC:3.1.1.33 xref: GO:0047593 xref: MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006897 name: 6-beta-hydroxyhyoscyamine epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = scopolamine + succinate + CO2." [EC:1.14.11.14, MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN] synonym: "(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)" EXACT [EC:1.14.11.14] synonym: "6beta-hydroxyhyoscyamine epoxidase activity" EXACT [EC:1.14.11.14] synonym: "hydroxyhyoscyamine dioxygenase activity" EXACT [EC:1.14.11.14] xref: EC:1.14.11.14 xref: GO:0047594 xref: MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0006898 name: 6-hydroxynicotinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin." [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN] synonym: "1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1] synonym: "6-hydroxynicotinic reductase activity" EXACT [EC:1.3.7.1] synonym: "6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1] synonym: "6-oxotetrahydro-nicotinate dehydrogenase activity" EXACT [EC:1.3.7.1] synonym: "6-oxotetrahydronicotinate dehydrogenase activity" EXACT [EC:1.3.7.1] synonym: "HNA reductase activity" EXACT [EC:1.3.7.1] xref: EC:1.3.7.1 xref: GO:0047595 xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN is_a: CCO:F0003237 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0006899 name: 6-methylsalicylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 6-methylsalicylate = 3-cresol + CO2." [EC:4.1.1.52, MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN] synonym: "6-methylsalicylate carboxy-lyase (3-cresol-forming)" EXACT [EC:4.1.1.52] synonym: "6-methylsalicylate carboxy-lyase activity" EXACT [EC:4.1.1.52] synonym: "6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity" EXACT [EC:4.1.1.52] synonym: "6-MSA decarboxylase activity" EXACT [EC:4.1.1.52] xref: EC:4.1.1.52 xref: GO:0047596 xref: MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006900 name: 6-oxocineole dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxocineole + NADPH + H+ + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo-[3.2.2]nonan-3-one + NADP+ + H2O." [EC:1.14.13.51, MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN] synonym: "6-oxocineole oxygenase activity" EXACT [EC:1.14.13.51] synonym: "6-oxocineole,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.51] xref: EC:1.14.13.51 xref: GO:0047597 xref: MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006901 name: 7-dehydrocholesterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+." [EC:1.3.1.21, MetaCyc:7-DEHYDROCHOLESTEROL-REDUCTASE-RXN] synonym: "7-DHC reductase activity" EXACT [EC:1.3.1.21] synonym: "cholesterol:NADP+ delta7-oxidoreductase activity" EXACT [EC:1.3.1.21] synonym: "sterol Delta(7)-reductase activity" BROAD [EC:1.3.1.21] synonym: "sterol delta7-reductase activity" EXACT [EC:1.3.1.21] xref: EC:1.3.1.21 xref: GO:0047598 xref: MetaCyc:7-DEHYDROCHOLESTEROL-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006902 name: 8-oxocoformycin reductase activity namespace: molecular_function def: "Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + NADPH + H+." [EC:1.1.1.235, MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN] synonym: "8-ketodeoxycoformycin reductase activity" EXACT [EC:1.1.1.235] synonym: "coformycin:NADP+ 8-oxidoreductase activity" EXACT [EC:1.1.1.235] xref: EC:1.1.1.235 xref: GO:0047599 xref: MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006903 name: abequosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid." [EC:2.4.1.60, MetaCyc:ABEQUOSYLTRANSFERASE-RXN] synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity" EXACT [EC:2.4.1.60] synonym: "trihexose diphospholipid abequosyltransferase activity" EXACT [EC:2.4.1.60] xref: EC:2.4.1.60 xref: GO:0047600 xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006904 name: acetate kinase (diphosphate) activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + acetate = phosphate + acetyl phosphate." [EC:2.7.2.12, MetaCyc:ACETATE-KINASE-(PYROPHOSPHATE)-RXN] synonym: "acetate kinase (pyrophosphate) activity" EXACT [EC:2.7.2.12] synonym: "diphosphate:acetate phosphotransferase activity" EXACT [EC:2.7.2.12] synonym: "pyrophosphate-acetate phosphotransferase activity" EXACT [EC:2.7.2.12] xref: EC:2.7.2.12 xref: GO:0047601 xref: MetaCyc:ACETATE-KINASE-(PYROPHOSPHATE)-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0006905 name: acetoacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + H+ = acetone + CO2." [EC:4.1.1.4, MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "acetoacetate carboxy-lyase (acetone-forming)" EXACT [EC:4.1.1.4] synonym: "acetoacetate carboxy-lyase activity" EXACT [EC:4.1.1.4] synonym: "acetoacetic acid decarboxylase activity" EXACT [EC:4.1.1.4] xref: EC:4.1.1.4 xref: GO:0047602 xref: MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006906 name: acetoacetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetyl-CoA + H2O = CoA + acetoacetate." [EC:3.1.2.11, MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN] synonym: "acetoacetyl CoA deacylase activity" EXACT [EC:3.1.2.11] synonym: "acetoacetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.11] synonym: "acetoacetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.11] xref: EC:3.1.2.11 xref: GO:0047603 xref: MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0006907 name: acetoin racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-acetoin = (R)-acetoin." [EC:5.1.2.4, MetaCyc:ACETOIN-RACEMASE-RXN] synonym: "acetylmethylcarbinol racemase activity" EXACT [EC:5.1.2.4] xref: EC:5.1.2.4 xref: GO:0047604 xref: MetaCyc:ACETOIN-RACEMASE-RXN is_a: CCO:F0003419 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: CCO:F0006908 name: acetolactate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2." [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]" RELATED [EC:4.1.1.5] synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.5] synonym: "alpha-acetolactate decarboxylase activity" EXACT [EC:4.1.1.5] xref: EC:4.1.1.5 xref: GO:0047605 xref: MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006909 name: acetone-cyanhydrin lyase activity namespace: molecular_function def: "Catalysis of the reaction: acetone cyanhydrin = cyanide + acetone." [EC:4.1.2.37, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN] synonym: "acetone-cyanohydrin acetone-lyase (cyanide-forming)" EXACT [EC:4.1.2.37] synonym: "acetone-cyanohydrin acetone-lyase activity" EXACT [EC:4.1.2.37] synonym: "acetone-cyanohydrin lyase activity" EXACT [] synonym: "alpha-hydroxynitrile lyase activity" EXACT [EC:4.1.2.37] xref: EC:4.1.2.37 xref: GO:0047606 xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006910 name: acetylindoxyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown." [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN] synonym: "N-acetylindoxyl:oxygen oxidoreductase activity" EXACT [EC:1.7.3.2] xref: EC:1.7.3.2 xref: GO:0047608 xref: MetaCyc:ACETYLINDOXYL-OXIDASE-RXN is_a: CCO:F0003258 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: CCO:F0006911 name: acetylputrescine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine." [EC:3.5.1.62, MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN] synonym: "N-acetylputrescine acetylhydrolase activity" EXACT [EC:3.5.1.62] xref: EC:3.5.1.62 xref: GO:0047609 xref: MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006912 name: acetylsalicylate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: acetylsalicylate + H2O = salicylate + acetate." [EC:3.1.1.55, MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN] synonym: "acetylsalicylate O-acetylhydrolase activity" EXACT [EC:3.1.1.55] synonym: "acetylsalicylic acid esterase activity" EXACT [EC:3.1.1.55] synonym: "aspirin esterase activity" EXACT [EC:3.1.1.55] synonym: "aspirin hydrolase activity" EXACT [EC:3.1.1.55] xref: EC:3.1.1.55 xref: GO:0047610 xref: MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006913 name: acetylspermidine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N1-acetylspermidine + H2O = acetate + spermidine." [EC:3.5.1.48, MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN] subset: gosubset_prok synonym: "8-N-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N(1)-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N(8)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48] synonym: "N(8)-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] synonym: "N(8)-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] synonym: "N-acetylspermidine deacetylase activity" BROAD [EC:3.5.1.48] synonym: "N1-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N8-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N8-acetylspermidine deacetylase activity" EXACT [EC:3.5.1.48] synonym: "N8-monoacetylspermidine deacetylase activity" EXACT [EC:3.5.1.48] xref: EC:3.5.1.48 xref: GO:0047611 xref: MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0006914 name: acid-CoA ligase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + an acid + CoA = GDP + phosphate + acyl-CoA." [EC:6.2.1.10, MetaCyc:ACID--COA-LIGASE-(GDP-FORMING)-RXN] synonym: "acid:CoA ligase (GDP-forming)" EXACT [EC:6.2.1.10] synonym: "acyl coenzyme A synthetase (guanosine diphosphate forming)" EXACT [EC:6.2.1.10] synonym: "acyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.10] xref: EC:6.2.1.10 xref: GO:0047612 xref: MetaCyc:ACID--COA-LIGASE-(GDP-FORMING)-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0006915 name: aconitate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: cis-aconitate = itaconate + CO2." [EC:4.1.1.6, MetaCyc:ACONITATE-DECARBOXYLASE-RXN] synonym: "CAD activity" BROAD [EC:4.1.1.6] synonym: "cis-aconitate carboxy-lyase (itaconate-forming)" EXACT [EC:4.1.1.6] synonym: "cis-aconitate carboxy-lyase activity" EXACT [EC:4.1.1.6] synonym: "cis-aconitic decarboxylase activity" EXACT [EC:4.1.1.6] xref: EC:4.1.1.6 xref: GO:0047613 xref: MetaCyc:ACONITATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006916 name: aconitate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: trans-aconitate = cis-aconitate." [EC:5.3.3.7, MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN] synonym: "aconitate D-isomerase activity" EXACT [] synonym: "aconitate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.7] synonym: "aconitate isomerase activity" BROAD [EC:5.3.3.7] xref: EC:5.3.3.7 xref: GO:0047614 xref: MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0006917 name: actinomycin lactonase activity namespace: molecular_function def: "Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone." [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN] synonym: "actinomycin lactonohydrolase activity" EXACT [EC:3.1.1.39] xref: EC:3.1.1.39 xref: GO:0047615 xref: MetaCyc:ACTINOMYCIN-LACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006918 name: acyl-CoA dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.8, MetaCyc:ACYL-COA-DEHYDROGENASE-(NADP+)-RXN] synonym: "2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.8] synonym: "acyl-CoA:NADP+ 2-oxidoreductase activity" EXACT [EC:1.3.1.8] synonym: "crotonyl coenzyme A reductase activity" EXACT [EC:1.3.1.8] synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.8] synonym: "enoyl coenzyme A reductase activity" EXACT [EC:1.3.1.8] xref: EC:1.3.1.8 xref: GO:0047616 xref: MetaCyc:ACYL-COA-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006919 name: acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN] subset: gosubset_prok synonym: "acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.20] synonym: "acyl coenzyme A thioesterase activity" EXACT [EC:3.1.2.20] synonym: "thioesterase B" RELATED [EC:3.1.2.20] synonym: "thioesterase II" RELATED [EC:3.1.2.20] xref: EC:3.1.2.20 xref: GO:0047617 xref: MetaCyc:ACYL-COA-HYDROLASE-RXN is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0006920 name: acylagmatine amidase activity namespace: molecular_function def: "Catalysis of the reaction: benzoylagmatine + H2O = benzoate + agmatine." [EC:3.5.1.40, MetaCyc:ACYLAGMATINE-AMIDASE-RXN] synonym: "acylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40] synonym: "acylagmatine deacylase activity" EXACT [EC:3.5.1.40] synonym: "benzoylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40] xref: EC:3.5.1.40 xref: GO:0047618 xref: MetaCyc:ACYLAGMATINE-AMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006921 name: acylcarnitine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine." [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN] synonym: "carnitine ester hydrolase activity" EXACT [EC:3.1.1.28] synonym: "HACH" RELATED [EC:3.1.1.28] synonym: "high activity acylcarnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "long-chain acyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "O-acylcarnitine acylhydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoyl carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoylcarnitine hydrolase activity" EXACT [EC:3.1.1.28] xref: EC:3.1.1.28 xref: GO:0047619 xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006922 name: acylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN] synonym: "ATP:acylglycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.94] synonym: "MGK" RELATED [EC:2.7.1.94] synonym: "monoacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.94] synonym: "monoacylglycerol kinase activity" EXACT [EC:2.7.1.94] synonym: "monoglyceride kinase activity" EXACT [EC:2.7.1.94] synonym: "monoglyceride phosphokinase activity" EXACT [EC:2.7.1.94] synonym: "sn-2-monoacylglycerol kinase activity" EXACT [EC:2.7.1.94] xref: EC:2.7.1.94 xref: GO:0047620 xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006923 name: acylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate." [EC:3.7.1.5, MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN] subset: gosubset_prok synonym: "3-acylpyruvate acylhydrolase activity" EXACT [EC:3.7.1.5] xref: EC:3.7.1.5 xref: GO:0047621 xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0006924 name: adenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = D-ribose + adenine." [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN] synonym: "adenosinase activity" EXACT [EC:3.2.2.7] synonym: "adenosine hydrolase activity" EXACT [EC:3.2.2.7] synonym: "adenosine ribohydrolase activity" EXACT [EC:3.2.2.7] synonym: "ANase activity" EXACT [EC:3.2.2.7] synonym: "N-ribosyladenine ribohydrolase activity" EXACT [EC:3.2.2.7] xref: EC:3.2.2.7 xref: GO:0047622 xref: MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0006925 name: adenosine-phosphate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-AMP + H2O = 5'-IMP + NH3." [EC:3.5.4.17, MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN] synonym: "adenine nucleotide deaminase activity" EXACT [EC:3.5.4.17] synonym: "adenosine (phosphate) deaminase activity" EXACT [EC:3.5.4.17] synonym: "adenosine-phosphate aminohydrolase activity" EXACT [EC:3.5.4.17] xref: EC:3.5.4.17 xref: GO:0047623 xref: MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0006926 name: adenosine-tetraphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate." [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN] subset: gosubset_prok synonym: "adenosine-tetraphosphate phosphohydrolase activity" EXACT [EC:3.6.1.14] xref: EC:3.6.1.14 xref: GO:0047624 xref: MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0006927 name: adenosylmethionine cyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine = 5'-methylthioadenosine + 2-aminobutan-4-olide." [EC:2.5.1.4, MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN] synonym: "adenosyl methionine cyclotransferase activity" EXACT [] synonym: "adenosylmethioninase activity" EXACT [EC:2.5.1.4] synonym: "S-adenosyl-L-methionine alkyltransferase (cyclizing)" EXACT [EC:2.5.1.4] xref: EC:2.5.1.4 xref: GO:0047625 xref: MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0006928 name: adenosylmethionine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + S-adenosyl-L-methionine = L-homoserine + methylthioadenosine." [EC:3.3.1.2, MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN] synonym: "adenosyl methionine hydrolase activity" EXACT [] synonym: "adenosylmethionine lyase activity" EXACT [EC:3.3.1.2] synonym: "methylmethionine-sulfonium-salt hydrolase activity" EXACT [EC:3.3.1.2] synonym: "S-adenosyl-L-methionine hydrolase activity" EXACT [EC:3.3.1.2] synonym: "S-adenosylmethionine cleaving enzyme activity" EXACT [EC:3.3.1.2] xref: EC:3.3.1.2 xref: GO:0047626 xref: MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN is_a: CCO:F0003372 ! trialkylsulfonium hydrolase activity [Term] id: CCO:F0006929 name: adenylylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: adenylylsulfate + H2O = AMP + SO4(2-) (sulfate)." [EC:3.6.2.1, MetaCyc:ADENYLYLSULFATASE-RXN] synonym: "adenosine 5-phosphosulfate sulfohydrolase activity" EXACT [EC:3.6.2.1] synonym: "adenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.1] synonym: "adenylylsulphatase activity" EXACT [] xref: EC:3.6.2.1 xref: GO:0047627 xref: MetaCyc:ADENYLYLSULFATASE-RXN is_a: CCO:F0003387 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides [Term] id: CCO:F0006930 name: ADP-thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate." [EC:2.7.1.118, MetaCyc:ADP--THYMIDINE-KINASE-RXN] synonym: "adenosine diphosphate-thymidine phosphotransferase activity" EXACT [EC:2.7.1.118] synonym: "ADP:dThd phosphotransferase activity" EXACT [EC:2.7.1.118] synonym: "ADP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.118] xref: EC:2.7.1.118 xref: GO:0047628 xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006931 name: ADP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + H2O = IDP + NH3." [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN] synonym: "adenosine diphosphate deaminase activity" EXACT [EC:3.5.4.7] synonym: "adenosinepyrophosphate deaminase activity" EXACT [EC:3.5.4.7] synonym: "ADP aminohydrolase activity" EXACT [EC:3.5.4.7] xref: EC:3.5.4.7 xref: GO:0047629 xref: MetaCyc:ADP-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0006932 name: ADP-phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(ADP)-2-phosphoglycerate + H2O = 3-(ADP)-glycerate + phosphate." [EC:3.1.3.28, MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN] synonym: "3-(ADP)-2-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.28] synonym: "adenosine diphosphate phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28] synonym: "ADPphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28] xref: EC:3.1.3.28 xref: GO:0047630 xref: MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0006933 name: ADP-ribose diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN] subset: gosubset_prok synonym: "adenosine diphosphoribose pyrophosphatase activity" EXACT [] synonym: "ADP-ribose phosphohydrolase activity" EXACT [] synonym: "ADP-ribose pyrophosphatase activity" EXACT [] synonym: "ADP-ribose ribophosphohydrolase activity" EXACT [EC:3.6.1.13] synonym: "ADPR-PPase activity" EXACT [] synonym: "ADPribose diphosphatase activity" EXACT [EC:3.6.1.13] synonym: "ADPribose pyrophosphatase activity" EXACT [EC:3.6.1.13] xref: EC:3.6.1.13 xref: GO:0047631 xref: MetaCyc:RXN0-1441 is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0006934 name: agmatine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN] subset: gosubset_prok synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.12] synonym: "agmatine iminohydrolase activity" EXACT [EC:3.5.3.12] xref: EC:3.5.3.12 xref: GO:0047632 xref: MetaCyc:AGMATINE-DEIMINASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0006935 name: agmatine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + agmatine = ADP + N4-phosphoagmatine." [EC:2.7.3.10, MetaCyc:AGMATINE-KINASE-RXN] synonym: "ATP:agmatine 4-N-phosphotransferase activity" EXACT [EC:2.7.3.10] synonym: "ATP:agmatine N4-phosphotransferase activity" EXACT [EC:2.7.3.10] synonym: "phosphagen phosphokinase activity" RELATED [EC:2.7.3.10] xref: EC:2.7.3.10 xref: GO:0047633 xref: MetaCyc:AGMATINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0006936 name: agmatine N4-coumaroyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = CoA + N-(4-guanidinobutyl)-N4-hydroxycinnamamide." [EC:2.3.1.64, MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN] synonym: "4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity" EXACT [EC:2.3.1.64] synonym: "4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity" EXACT [EC:2.3.1.64] synonym: "agmatine coumaroyltransferase activity" EXACT [EC:2.3.1.64] synonym: "p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity" EXACT [EC:2.3.1.64] xref: EC:2.3.1.64 xref: GO:0047634 xref: MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006937 name: alanine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid." [EC:2.6.1.12, MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN] synonym: "alanine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "alanine-keto acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "alanine-oxo acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "alanine-oxo-acid aminotransferase activity" EXACT [] synonym: "L-alanine-alpha-keto acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "L-alanine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "leucine-alanine transaminase activity" EXACT [EC:2.6.1.12] xref: EC:2.6.1.12 xref: GO:0047635 xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006938 name: alanopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH." [EC:1.5.1.17, MetaCyc:ALANOPINE-DEHYDROGENASE-RXN] synonym: "2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)" EXACT [EC:1.5.1.17] synonym: "ADH" RELATED [EC:1.5.1.17] synonym: "alanopine: NAD oxidoreductase activity" EXACT [EC:1.5.1.17] synonym: "alanopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.17] synonym: "alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity" EXACT [EC:1.5.1.17] synonym: "ALPDH" RELATED [EC:1.5.1.17] synonym: "meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.17] xref: EC:1.5.1.17 xref: GO:0047636 xref: MetaCyc:ALANOPINE-DEHYDROGENASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006939 name: alanylphosphatidylglycerol synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol." [EC:2.3.2.11, MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN] synonym: "alanyl phosphatidylglycerol synthetase activity" EXACT [EC:2.3.2.11] synonym: "L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity" EXACT [EC:2.3.2.11] synonym: "O-alanylphosphatidylglycerol synthase activity" EXACT [EC:2.3.2.11] xref: EC:2.3.2.11 xref: GO:0047637 xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0006940 name: albendazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: albendazole + NADPH + O2 = albendazole S-oxide + NADP+ + H2O." [EC:1.14.13.32, MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN] synonym: "albendazole oxidase activity" EXACT [EC:1.14.13.32] synonym: "albendazole sulfoxidase activity" EXACT [EC:1.14.13.32] synonym: "albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)" EXACT [EC:1.14.13.32] xref: EC:1.14.13.32 xref: GO:0047638 xref: MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006941 name: alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2." [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN] comment: Note that the enzyme alcohol oxidase also has methanol oxidase activity (GO:0046563). synonym: "alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.13] synonym: "AOX activity" EXACT [EC:1.1.3.13] synonym: "ethanol oxidase activity" EXACT [EC:1.1.3.13] xref: EC:1.1.3.13 xref: GO:0047639 xref: MetaCyc:ALCOHOL-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0006942 name: aldose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH." [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN] synonym: "aldose dehydrogenase activity" EXACT [EC:1.1.1.121] synonym: "D-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.121] synonym: "dehydrogenase, D-aldohexose" EXACT [EC:1.1.1.121] xref: EC:1.1.1.121 xref: GO:0047640 xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006943 name: aldose-6-phosphate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NADP+ = D-glucose 6-phosphate + NADPH." [EC:1.1.1.200, MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-(NADPH)-RXN] synonym: "A6PR" RELATED [EC:1.1.1.200] synonym: "alditol 6-phosphate:NADP 1-oxidoreductase activity" EXACT [EC:1.1.1.200] synonym: "aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200] synonym: "aldose-6-P reductase activity" EXACT [EC:1.1.1.200] synonym: "aldose-6-phosphate reductase activity" EXACT [EC:1.1.1.200] synonym: "D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.200] synonym: "NADP-dependent aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200] synonym: "NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.200] xref: EC:1.1.1.200 xref: GO:0047641 xref: MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-(NADPH)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006944 name: aldose beta-D-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside." [EC:2.4.1.162, MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN] synonym: "aldose b-D-fructosyltransferase activity" EXACT [] synonym: "alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.162] xref: EC:2.4.1.162 xref: GO:0047642 xref: MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN is_a: CCO:F0008006 ! fructosyltransferase activity [Term] id: CCO:F0006945 name: alginate synthase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)." [EC:2.4.1.33, MetaCyc:ALGINATE-SYNTHASE-RXN] synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" EXACT [EC:2.4.1.33] synonym: "mannuronosyl transferase activity" EXACT [EC:2.4.1.33] xref: EC:2.4.1.33 xref: GO:0047643 xref: MetaCyc:ALGINATE-SYNTHASE-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006946 name: alizarin 2-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + alizarin = UDP + 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone." [EC:2.4.1.103, MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "alizarin 2-b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.103] synonym: "UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity" EXACT [EC:2.4.1.103] synonym: "uridine diphosphoglucose-alizarin glucosyltransferase activity" EXACT [EC:2.4.1.103] xref: EC:2.4.1.103 xref: GO:0047644 xref: MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006947 name: alkan-1-ol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor." [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-(ACCEPTOR)-RXN] synonym: "alkan-1-ol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.20] synonym: "alkan-1-ol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.20] synonym: "polyethylene glycol dehydrogenase activity" NARROW [EC:1.1.99.20] xref: EC:1.1.99.20 xref: GO:0047645 xref: MetaCyc:ALKAN-1-OL-DEHYDROGENASE-(ACCEPTOR)-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0006948 name: alkanal monooxygenase (FMN-linked) activity namespace: molecular_function def: "Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light." [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-(FMN-LINKED)-RXN] subset: gosubset_prok synonym: "aldehyde monooxygenase activity" BROAD [EC:1.14.14.3] synonym: "alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)" EXACT [EC:1.14.14.3] synonym: "bacterial luciferase activity" EXACT [EC:1.14.14.3] synonym: "vibrio fischeri luciferase activity" EXACT [EC:1.14.14.3] xref: EC:1.14.14.3 xref: GO:0047646 xref: MetaCyc:ALKANAL-MONOOXYGENASE-(FMN-LINKED)-RXN is_a: CCO:F0003295 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006949 name: alkylacetylglycerophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-alkyl-2-acetyl-sn-glycerol + phosphate." [EC:3.1.3.59, MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.59] synonym: "1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity" EXACT [EC:3.1.3.59] synonym: "alkylacetylglycerophosphate phosphatase activity" EXACT [EC:3.1.3.59] xref: EC:3.1.3.59 xref: GO:0047647 xref: MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0006950 name: alkylamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylamine." [EC:3.5.1.39, MetaCyc:ALKYLAMIDASE-RXN] synonym: "N-methylhexanamide amidohydrolase activity" EXACT [EC:3.5.1.39] xref: EC:3.5.1.39 xref: GO:0047648 xref: MetaCyc:ALKYLAMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006951 name: alkylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate." [EC:2.7.1.93, MetaCyc:ALKYLGLYCEROL-KINASE-RXN] synonym: "1-alkylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.93] synonym: "alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93] synonym: "ATP-alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93] synonym: "ATP:1-alkyl-sn-glycerol phosphotransferase activity" EXACT [EC:2.7.1.93] synonym: "ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.93] xref: EC:2.7.1.93 xref: GO:0047649 xref: MetaCyc:ALKYLGLYCEROL-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006952 name: alkylglycerone kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + O-alkylglycerone = ADP + O-alkylglycerone phosphate." [EC:2.7.1.84, MetaCyc:ALKYLGLYCERONE-KINASE-RXN] synonym: "alkyldihydroxyacetone kinase (phosphorylating)" EXACT [EC:2.7.1.84] synonym: "alkyldihydroxyacetone kinase activity" EXACT [EC:2.7.1.84] synonym: "ATP:O-alkylglycerone phosphotransferase activity" EXACT [EC:2.7.1.84] xref: EC:2.7.1.84 xref: GO:0047650 xref: MetaCyc:ALKYLGLYCERONE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006953 name: alkylhalidase activity namespace: molecular_function def: "Catalysis of the reaction: bromochloromethane + H2O = formaldehyde + bromide + chloride." [EC:3.8.1.1, MetaCyc:ALKYLHALIDASE-RXN] subset: gosubset_prok synonym: "alkyl-halide halidohydrolase activity" EXACT [EC:3.8.1.1] synonym: "haloalkane halidohydrolase activity" EXACT [EC:3.8.1.1] synonym: "halogenase activity" RELATED [EC:3.8.1.1] xref: EC:3.8.1.1 xref: GO:0047651 xref: MetaCyc:ALKYLHALIDASE-RXN is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0006954 name: allantoate deiminase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + 2 allantoate = O2 + 2 CO2 + 2 NH3 + 2 ureidoglycine." [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN] synonym: "allantoate amidinohydrolase (decarboxylating)" EXACT [EC:3.5.3.9] synonym: "allantoate amidohydrolase activity" EXACT [EC:3.5.3.9] xref: EC:3.5.3.9 xref: GO:0047652 xref: MetaCyc:ALLANTOATE-DEIMINASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0006955 name: allantoin racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)(+)-allantoin = (R)(-)-allantoin." [EC:5.1.99.3, MetaCyc:ALLANTOIN-RACEMASE-RXN] xref: EC:5.1.99.3 xref: GO:0047653 xref: MetaCyc:ALLANTOIN-RACEMASE-RXN is_a: CCO:F0003417 ! racemase and epimerase activity [Term] id: CCO:F0006956 name: alliin lyase activity namespace: molecular_function def: "Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate." [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN] synonym: "alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "alliin alkyl-sulfenate-lyase activity" EXACT [EC:4.4.1.4] synonym: "alliinase activity" EXACT [EC:4.4.1.4] synonym: "cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "cysteine sulphoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)" EXACT [EC:4.4.1.4] synonym: "S-alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] xref: EC:4.4.1.4 xref: GO:0047654 xref: MetaCyc:ALLIIN-LYASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0006957 name: allyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + NADPH." [EC:1.1.1.54, MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN] synonym: "allyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.54] xref: EC:1.1.1.54 xref: GO:0047655 xref: MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006958 name: alpha,alpha-trehalose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.64, MetaCyc:ALPHA] subset: gosubset_prok synonym: "a,a-trehalose phosphorylase activity" EXACT [] synonym: "alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.64] synonym: "trehalose phosphorylase" BROAD [EC:2.4.1.64] xref: EC:2.4.1.64 xref: GO:0047656 xref: MetaCyc:ALPHA is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0006959 name: alpha-1,3-glucan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1." [EC:2.4.1.183, MetaCyc:ALPHA-1] synonym: "1,3-alpha-D-glucan synthase activity" EXACT [EC:2.4.1.183] synonym: "1,3-alpha-glucan synthase activity" EXACT [] synonym: "a-1,3-glucan synthase activity" EXACT [] synonym: "UDP-glucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183] synonym: "UDPglucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183] synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.183] xref: EC:2.4.1.183 xref: GO:0047657 xref: MetaCyc:ALPHA-1 is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006960 name: alpha-amino-acid esterase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol." [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN] subset: gosubset_prok synonym: "a-amino-acid esterase activity" EXACT [] synonym: "alpha-amino acid ester hydrolase activity" EXACT [EC:3.1.1.43] synonym: "alpha-amino-acid ester hydrolase activity" EXACT [EC:3.1.1.43] synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" EXACT [EC:3.1.1.43] xref: EC:3.1.1.43 xref: GO:0047658 xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0006961 name: alpha-santonin 1,2-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+." [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-1] synonym: "1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.47] synonym: "a-santonin 1,2-reductase activity" EXACT [] xref: EC:1.3.1.47 xref: GO:0047659 xref: MetaCyc:ALPHA-SANTONIN-1 is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006962 name: amidinoaspartase activity namespace: molecular_function def: "Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea." [EC:3.5.3.14, MetaCyc:AMIDINOASPARTASE-RXN] synonym: "amidinoaspartic amidinohydrolase activity" EXACT [EC:3.5.3.14] synonym: "N-amidino-L-aspartate amidinohydrolase activity" EXACT [EC:3.5.3.14] xref: EC:3.5.3.14 xref: GO:0047660 xref: MetaCyc:AMIDINOASPARTASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0006963 name: amino-acid racemase activity namespace: molecular_function def: "Catalysis of the reaction: an L-amino acid = a D-amino acid." [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN] subset: gosubset_prok synonym: "L-amino acid racemase activity" EXACT [EC:5.1.1.10] xref: EC:5.1.1.10 xref: GO:0047661 xref: MetaCyc:AMINO-ACID-RACEMASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0006964 name: aminobenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2." [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN] synonym: "aminobenzoate carboxy-lyase (aniline-forming)" EXACT [EC:4.1.1.24] synonym: "aminobenzoate carboxy-lyase activity" EXACT [EC:4.1.1.24] xref: EC:4.1.1.24 xref: GO:0047662 xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006965 name: aminoglycoside 6'-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 6'-N-acetylaminoglycoside. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring." [GOC:cb] subset: gosubset_prok synonym: "6'-aminoglycoside-N-acetyltransferase activity" EXACT [EC:2.3.1.82] synonym: "AAC(6') activity" RELATED [EC:2.3.1.82] synonym: "acetyl-CoA:kanamycin-B N6'-acetyltransferase activity" NARROW [EC:2.3.1.82] synonym: "aminoglycoside N6'-acetyltransferase activity" EXACT [] synonym: "aminoglycoside-6'-acetyltransferase activity" EXACT [EC:2.3.1.82] synonym: "aminoglycoside-6-N-acetyltransferase activity" EXACT [EC:2.3.1.82] synonym: "kanamycin 6'-N-acetyltransferase activity" NARROW [] xref: EC:2.3.1.82 xref: GO:0047663 xref: MetaCyc:AMINOGLYCOSIDE-N6 is_a: CCO:F0005513 ! aminoglycoside N-acetyltransferase activity [Term] id: CCO:F0006966 name: aminoimidazolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminoimidazole + H2O = unidentified product + NH3." [EC:3.5.4.8, MetaCyc:AMINOIMIDAZOLASE-RXN] synonym: "4-aminoimidazole aminohydrolase activity" EXACT [EC:3.5.4.8] synonym: "4-aminoimidazole hydrolase activity" EXACT [EC:3.5.4.8] xref: EC:3.5.4.8 xref: GO:0047664 xref: MetaCyc:AMINOIMIDAZOLASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: CCO:F0006967 name: aminolevulinate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine." [EC:2.6.1.43, MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN] synonym: "4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "4,5-dioxovaleric acid aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "4,5-dioxovaleric transaminase activity" EXACT [EC:2.6.1.43] synonym: "5-aminolevulinate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "5-aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "alanine-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "alanine-gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "alanine:4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "aminolevulinate aminotransferase activity" EXACT [] synonym: "aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "dioxovalerate transaminase activity" EXACT [EC:2.6.1.43] synonym: "DOVA transaminase activity" EXACT [EC:2.6.1.43] synonym: "gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "gamma,delta-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "L-alanine-4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "L-alanine:4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "L-alanine:dioxovalerate transaminase activity" EXACT [EC:2.6.1.43] xref: EC:2.6.1.43 xref: GO:0047665 xref: MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0006968 name: ammonia kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NH3 = ADP + phosphoramide." [EC:2.7.3.8, MetaCyc:AMMONIA-KINASE-RXN] synonym: "ATP:ammonia phosphotransferase activity" EXACT [EC:2.7.3.8] synonym: "phosphoramidate-adenosine diphosphate phosphotransferase activity" EXACT [EC:2.7.3.8] synonym: "phosphoramidate-ADP-phosphotransferase activity" EXACT [EC:2.7.3.8] xref: EC:2.7.3.8 xref: GO:0047666 xref: MetaCyc:AMMONIA-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0006969 name: AMP-thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate." [EC:2.7.1.114, MetaCyc:AMP--THYMIDINE-KINASE-RXN] synonym: "adenylate-nucleoside phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "adenylic acid:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "AMP:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "AMP:deoxythymidine kinase activity" EXACT [EC:2.7.1.114] synonym: "AMP:dThd kinase activity" EXACT [EC:2.7.1.114] synonym: "AMP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "thymidine phosphotransferase activity" EXACT [EC:2.7.1.114] xref: EC:2.7.1.114 xref: GO:0047667 xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0006970 name: amygdalin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose." [EC:3.2.1.117, MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN] synonym: "amygdalin b-glucosidase activity" EXACT [] synonym: "amygdalin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.117] synonym: "amygdalin glucosidase activity" EXACT [EC:3.2.1.117] synonym: "amygdalin hydrolase activity" EXACT [EC:3.2.1.117] synonym: "amygdalinase" BROAD [EC:3.2.1.117] xref: EC:3.2.1.117 xref: GO:0047668 xref: MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0006971 name: amylosucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)." [EC:2.4.1.4, MetaCyc:AMYLOSUCRASE-RXN] subset: gosubset_prok synonym: "sucrose-1,4-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4] synonym: "sucrose-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4] synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.4] xref: EC:2.4.1.4 xref: GO:0047669 xref: MetaCyc:AMYLOSUCRASE-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0006972 name: anhydrotetracycline monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: anhydrotetracycline + NADPH + O2 = 12-dehydrotetracycline + NADP+ + H2O." [EC:1.14.13.38, MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN] synonym: "anhydrotetracycline oxygenase activity" EXACT [EC:1.14.13.38] synonym: "anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.38] synonym: "ATC oxygenase activity" EXACT [EC:1.14.13.38] xref: EC:1.14.13.38 xref: GO:0047670 xref: MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0006973 name: anthranilate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + anthranilate = diphosphate + N-adenylylanthranilate." [EC:2.7.7.55, MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN] synonym: "anthranilic acid adenylyltransferase activity" EXACT [EC:2.7.7.55] synonym: "ATP:anthranilate adenylyltransferase activity" EXACT [] synonym: "ATP:anthranilate N-adenylyltransferase activity" EXACT [EC:2.7.7.55] xref: EC:2.7.7.55 xref: GO:0047671 xref: MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0006974 name: anthranilate N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + anthranilate = CoA + N-benzoylanthranilate." [EC:2.3.1.144, MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN] synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.3.1.144] xref: EC:2.3.1.144 xref: GO:0047672 xref: MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0006975 name: anthranilate N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + anthranilate = CoA + N-malonylanthranilate." [EC:2.3.1.113, MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN] synonym: "malonyl-CoA:anthranilate N-malonyltransferase activity" EXACT [EC:2.3.1.113] xref: EC:2.3.1.113 xref: GO:0047673 xref: MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN is_a: CCO:F0008003 ! N-malonyltransferase activity [Term] id: CCO:F0006976 name: apiose 1-reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-apiitol + NAD+ = D-apiose + NADH." [EC:1.1.1.114, MetaCyc:APIOSE-1-REDUCTASE-RXN] synonym: "D-apiitol reductase activity" EXACT [EC:1.1.1.114] synonym: "D-apiitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.114] synonym: "D-apiose reductase activity" EXACT [EC:1.1.1.114] xref: EC:1.1.1.114 xref: GO:0047674 xref: MetaCyc:APIOSE-1-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006977 name: arabinonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O." [EC:4.2.1.5, MetaCyc:ARABINONATE-DEHYDRATASE-RXN] synonym: "D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)" EXACT [EC:4.2.1.5] synonym: "D-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.5] xref: EC:4.2.1.5 xref: GO:0047675 xref: MetaCyc:ARABINONATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0006978 name: arachidonate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA." [EC:6.2.1.15, MetaCyc:ARACHIDONATE--COA-LIGASE-RXN] synonym: "arachidonate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.15] synonym: "arachidonoyl-CoA synthetase activity" EXACT [EC:6.2.1.15] xref: EC:6.2.1.15 xref: GO:0047676 xref: MetaCyc:ARACHIDONATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0006979 name: arachidonate 8-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.40, MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN] synonym: "8(R)-lipoxygenase activity" EXACT [EC:1.13.11.40] synonym: "8-lipoxygenase activity" NARROW [EC:1.13.11.40] synonym: "arachidonate:oxygen 8-oxidoreductase activity" EXACT [EC:1.13.11.40] xref: EC:1.13.11.40 xref: GO:0047677 xref: MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006980 name: arginine 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O." [EC:1.13.12.1, MetaCyc:ARGININE-2-MONOOXYGENASE-RXN] synonym: "arginine decarboxy-oxidase activity" EXACT [EC:1.13.12.1] synonym: "arginine monooxygenase activity" EXACT [EC:1.13.12.1] synonym: "arginine oxygenase (decarboxylating) activity" EXACT [EC:1.13.12.1] synonym: "L-arginine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.1] xref: EC:1.13.12.1 xref: GO:0047678 xref: MetaCyc:ARGININE-2-MONOOXYGENASE-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: CCO:F0006981 name: arginine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine = D-arginine." [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN] xref: EC:5.1.1.9 xref: GO:0047679 xref: MetaCyc:ARGININE-RACEMASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0006982 name: aryl-acylamidase activity namespace: molecular_function def: "Catalysis of the reaction: an anilide + H2O = a carboxylate + aniline." [EC:3.5.1.13, MetaCyc:ARYL-ACYLAMIDASE-RXN] subset: gosubset_prok synonym: "AAA-1" RELATED [EC:3.5.1.13] synonym: "AAA-2" RELATED [EC:3.5.1.13] synonym: "aryl-acylamide amidohydrolase activity" EXACT [EC:3.5.1.13] synonym: "brain acetylcholinesterase (is associated with AAA-2)" EXACT [EC:3.5.1.13] synonym: "pseudocholinesterase (associated with arylacylamidase)" EXACT [EC:3.5.1.13] xref: EC:3.5.1.13 xref: GO:0047680 xref: MetaCyc:ARYL-ACYLAMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0006983 name: aryl-alcohol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH." [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-(NADP+)-RXN] synonym: "aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.91] synonym: "aryl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.91] synonym: "coniferyl alcohol dehydrogenase" BROAD [EC:1.1.1.91] synonym: "NADPH-linked benzaldehyde reductase activity" EXACT [EC:1.1.1.91] xref: EC:1.1.1.91 xref: GO:0047681 xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006984 name: aryl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2." [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN] synonym: "arom. alcohol oxidase activity" EXACT [EC:1.1.3.7] synonym: "aryl alcohol oxidase activity" EXACT [EC:1.1.3.7] synonym: "aryl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.7] synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7] xref: EC:1.1.3.7 xref: GO:0047682 xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0006985 name: aryl-aldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP." [EC:1.2.1.30, MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-(NADP+)-RXN] synonym: "aromatic acid reductase activity" EXACT [EC:1.2.1.30] synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" EXACT [EC:1.2.1.30] xref: EC:1.2.1.30 xref: GO:0047683 xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0006986 name: arylamine glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine." [EC:2.4.1.71, MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP glucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71] synonym: "UDP-glucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71] synonym: "UDPglucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71] synonym: "uridine diphosphoglucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71] xref: EC:2.4.1.71 xref: GO:0047684 xref: MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0006987 name: amine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate." [EC:2.8.2.3, MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity" EXACT [EC:2.8.2.3] synonym: "amine N-sulfotransferase activity" EXACT [EC:2.8.2.3] synonym: "amine sulphotransferase activity" EXACT [] synonym: "arylamine sulfotransferase activity" EXACT [] xref: EC:2.8.2.3 xref: GO:0047685 xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0006988 name: arylsulfate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate." [EC:2.8.2.22, MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN] subset: gosubset_prok synonym: "arylsulfate-phenol sulfotransferase activity" EXACT [EC:2.8.2.22] synonym: "arylsulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.22] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.22] synonym: "arylsulphate sulphotransferase activity" EXACT [] synonym: "ASST" RELATED [EC:2.8.2.22] xref: EC:2.8.2.22 xref: GO:0047686 xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0006989 name: ascorbate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + O2 + ascorbate = L-threonate + oxalate." [EC:1.13.11.13, MetaCyc:ASCORBATE-2] synonym: "AAoxygenase activity" EXACT [EC:1.13.11.13] synonym: "ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving)" EXACT [EC:1.13.11.13] xref: EC:1.13.11.13 xref: GO:0047687 xref: MetaCyc:ASCORBATE-2 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0006990 name: aspartate 4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = L-alanine + CO2." [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "aminomalonic decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartate omega-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartic beta-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartic omega-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "cysteine sulfinic desulfinase activity" EXACT [EC:4.1.1.12] synonym: "desulfinase activity" EXACT [EC:4.1.1.12] synonym: "L-aspartate 4-carboxy-lyase (L-alanine-forming)" EXACT [EC:4.1.1.12] synonym: "L-aspartate 4-carboxy-lyase activity" EXACT [EC:4.1.1.12] synonym: "L-aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "L-cysteine sulfinate acid desulfinase activity" EXACT [EC:4.1.1.12] xref: EC:4.1.1.12 xref: GO:0047688 xref: MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0006991 name: aspartate racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = D-aspartate." [EC:5.1.1.13, MetaCyc:ASPARTATE-RACEMASE-RXN] subset: gosubset_prok synonym: "D-aspartate racemase activity" EXACT [EC:5.1.1.13] xref: EC:5.1.1.13 xref: GO:0047689 xref: MetaCyc:ASPARTATE-RACEMASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0006992 name: aspartyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + hydroxylamine = NH3 + L-aspartylhydroxamate." [EC:2.3.2.7, MetaCyc:ASPARTYLTRANSFERASE-RXN] synonym: "aspartotransferase activity" EXACT [EC:2.3.2.7] synonym: "beta-aspartyl transferase activity" EXACT [EC:2.3.2.7] synonym: "L-asparagine:hydroxylamine gamma-aspartyltransferase activity" EXACT [EC:2.3.2.7] xref: EC:2.3.2.7 xref: GO:0047690 xref: MetaCyc:ASPARTYLTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0006993 name: aspulvinone dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 dimethylallyl diphosphate + aspulvinone E = 2 diphosphate + aspulvinone H." [EC:2.5.1.35, MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN] synonym: "dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity" EXACT [EC:2.5.1.35] synonym: "dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity" EXACT [EC:2.5.1.35] xref: EC:2.5.1.35 xref: GO:0047691 xref: MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0006994 name: ATP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ITP + NH3." [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN] synonym: "adenosine triphosphate deaminase activity" EXACT [EC:3.5.4.18] synonym: "ATP aminohydrolase activity" EXACT [EC:3.5.4.18] xref: EC:3.5.4.18 xref: GO:0047692 xref: MetaCyc:ATP-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0006995 name: ATP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = AMP + diphosphate." [EC:3.6.1.8, MetaCyc:ATP-PYROPHOSPHATASE-RXN] subset: gosubset_prok synonym: "adenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.8] synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.8] synonym: "ATP diphosphohydrolase (diphosphate-forming)" EXACT [EC:3.6.1.8] synonym: "ATP pyrophosphatase activity" EXACT [] xref: EC:3.6.1.8 xref: GO:0047693 xref: MetaCyc:ATP-PYROPHOSPHATASE-RXN is_a: CCO:F0006737 ! nucleoside-triphosphate diphosphatase activity [Term] id: CCO:F0006996 name: barbiturase activity namespace: molecular_function def: "Catalysis of the reaction: barbiturate + H2O = malonate + urea." [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN] synonym: "barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)" EXACT [EC:3.5.2.1] xref: EC:3.5.2.1 xref: GO:0047694 xref: MetaCyc:BARBITURASE-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0006997 name: benzoin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: benzoin = 2 benzaldehyde." [EC:4.1.2.38, MetaCyc:BENZOIN-ALDOLASE-RXN] subset: gosubset_prok synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity" EXACT [EC:4.1.2.38] synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)" EXACT [EC:4.1.2.38] synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38] synonym: "benzaldehyde lyase activity" EXACT [EC:4.1.2.38] synonym: "diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38] xref: EC:4.1.2.38 xref: GO:0047695 xref: MetaCyc:BENZOIN-ALDOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0006998 name: beta-adrenergic receptor kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor." [EC:2.7.11.15, MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN] synonym: "[b-adrenergic-receptor] kinase activity" EXACT [EC:2.7.11.15] synonym: "ADRBK1" RELATED [EC:2.7.11.15] synonym: "adrenergic receptor kinase activity" BROAD [EC:2.7.11.15] synonym: "ATP:beta-adrenergic-receptor phosphotransferase activity" BROAD [EC:2.7.11.15] synonym: "BARK1" RELATED [EC:2.7.11.15] synonym: "beta-adrenergic receptor-specific kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-adrenergic-receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.15] synonym: "beta-adrenergic-receptor kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-adrenoceptor kinase 1 activity" NARROW [EC:2.7.11.15] synonym: "beta-adrenoceptor kinase 2 activity" NARROW [EC:2.7.11.15] synonym: "beta-adrenoceptor kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-AR kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-ARK" RELATED [EC:2.7.11.15] synonym: "beta-ARK 1" RELATED [EC:2.7.11.15] synonym: "beta-ARK 2" RELATED [EC:2.7.11.15] synonym: "beta-receptor kinase activity" EXACT [EC:2.7.11.15] synonym: "beta2ARK" RELATED [EC:2.7.11.15] synonym: "betaARK1" RELATED [EC:2.7.11.15] synonym: "GRK2" RELATED [EC:2.7.11.15] synonym: "GRK3" RELATED [EC:2.7.11.15] synonym: "STK15" RELATED [EC:2.7.11.15] xref: EC:2.7.11.15 xref: GO:0047696 xref: MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0006999 name: beta-alanopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-alanopine + NAD+ + H2O = beta-alanine + pyruvate + NADH." [EC:1.5.1.26, MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN] synonym: "b-alanopine dehydrogenase activity" EXACT [] synonym: "N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)" EXACT [EC:1.5.1.26] xref: EC:1.5.1.26 xref: GO:0047697 xref: MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007000 name: beta-alanyl-CoA ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3." [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN] synonym: "b-alanyl-CoA ammonia-lyase activity" EXACT [] synonym: "beta-alanyl coenzyme A ammonia-lyase activity" EXACT [EC:4.3.1.6] synonym: "beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)" EXACT [EC:4.3.1.6] xref: EC:4.3.1.6 xref: GO:0047698 xref: MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0007001 name: beta-diketone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: nonane-4,6-dione + H2O = pentan-2-one + butanoate." [EC:3.7.1.7, MetaCyc:BETA-DIKETONE-HYDROLASE-RXN] synonym: "b-diketone hydrolase activity" EXACT [] synonym: "nonane-4,6-dione acylhydrolase activity" EXACT [EC:3.7.1.7] synonym: "oxidized PVA hydrolase activity" EXACT [EC:3.7.1.7] xref: EC:3.7.1.7 xref: GO:0047699 xref: MetaCyc:BETA-DIKETONE-HYDROLASE-RXN is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0007002 name: beta-glucoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose." [EC:2.7.1.85, MetaCyc:BETA-GLUCOSIDE-KINASE-RXN] subset: gosubset_prok synonym: "ATP:cellobiose 6-phosphotransferase activity" EXACT [EC:2.7.1.85] synonym: "b-glucoside kinase activity" EXACT [] synonym: "beta-D-glucoside kinase (phosphorylating)" EXACT [EC:2.7.1.85] xref: EC:2.7.1.85 xref: GO:0047700 xref: MetaCyc:BETA-GLUCOSIDE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007003 name: beta-L-arabinosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol." [EC:3.2.1.88, MetaCyc:BETA-L-ARABINOSIDASE-RXN] synonym: "b-L-arabinosidase activity" EXACT [] synonym: "beta-L-arabinoside arabinohydrolase activity" EXACT [EC:3.2.1.88] synonym: "vicianosidase activity" EXACT [EC:3.2.1.88] xref: EC:3.2.1.88 xref: GO:0047701 xref: MetaCyc:BETA-L-ARABINOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007004 name: beta-lysine 5,6-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate." [EC:5.4.3.3, MetaCyc:BETA-LYSINE-5] subset: gosubset_prok synonym: "(3S)-3,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.3] synonym: "b-lysine 5,6-aminomutase activity" EXACT [] synonym: "beta-lysine mutase activity" EXACT [EC:5.4.3.3] synonym: "L-beta-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.3] xref: EC:5.4.3.3 xref: GO:0047702 xref: MetaCyc:BETA-LYSINE-5 is_a: CCO:F0003430 ! intramolecular transferase activity, transferring amino groups [Term] id: CCO:F0007005 name: beta-nitroacrylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + NADPH." [EC:1.3.1.16, MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN] synonym: "3-nitropropanoate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.16] synonym: "b-nitroacrylate reductase activity" EXACT [] xref: EC:1.3.1.16 xref: GO:0047703 xref: MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007006 name: bile-salt sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "BAST I activity" NARROW [EC:2.8.2.14] synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14] synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "bile-salt sulphotransferase activity" EXACT [] synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14] xref: EC:2.8.2.14 xref: GO:0047704 xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007007 name: bilirubin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O." [EC:1.3.3.5, MetaCyc:BILIRUBIN-OXIDASE-RXN] synonym: "bilirubin oxidase M-1" RELATED [EC:1.3.3.5] synonym: "bilirubin:oxygen oxidoreductase activity" EXACT [EC:1.3.3.5] xref: EC:1.3.3.5 xref: GO:0047705 xref: MetaCyc:BILIRUBIN-OXIDASE-RXN is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0007008 name: biochanin-A reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + NADPH." [EC:1.3.1.46, MetaCyc:BIOCHANIN-A-REDUCTASE-RXN] synonym: "dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.46] xref: EC:1.3.1.46 xref: GO:0047706 xref: MetaCyc:BIOCHANIN-A-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007009 name: biotin-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA." [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN] synonym: "biotin CoA synthetase activity" EXACT [EC:6.2.1.11] synonym: "biotin:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.11] synonym: "biotinyl coenzyme A synthetase activity" EXACT [EC:6.2.1.11] synonym: "biotinyl-CoA synthetase activity" EXACT [EC:6.2.1.11] xref: EC:6.2.1.11 xref: GO:0047707 xref: MetaCyc:BIOTIN--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007010 name: biotinidase activity namespace: molecular_function def: "Catalysis of the reaction: biotin amide + H2O = biotin + NH3." [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN] synonym: "amidohydrolase biotinidase activity" EXACT [EC:3.5.1.12] synonym: "biotin-amide amidohydrolase activity" EXACT [EC:3.5.1.12] xref: EC:3.5.1.12 xref: GO:0047708 xref: MetaCyc:BIOTINIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007011 name: bis(2-ethylhexyl)phthalate esterase activity namespace: molecular_function def: "Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexyl phthalate + 2-ethylhexan-1-ol." [EC:3.1.1.60, MetaCyc:BIS(2-ETHYLHEXYL)PHTHALATE-ESTERASE-RXN] synonym: "bis(2-ethylhexyl)phthalate acylhydrolase activity" EXACT [EC:3.1.1.60] synonym: "DEHP esterase activity" EXACT [EC:3.1.1.60] xref: EC:3.1.1.60 xref: GO:0047709 xref: MetaCyc:BIS(2-ETHYLHEXYL)PHTHALATE-ESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007012 name: bis(5'-adenosyl)-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP." [EC:3.6.1.29, MetaCyc:BIS(5] synonym: "1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29] synonym: "AP(3)A hydrolase activity" EXACT [EC:3.6.1.29] synonym: "AP(3)Aase activity" EXACT [EC:3.6.1.29] synonym: "AP3A hydrolase activity" EXACT [EC:3.6.1.29] synonym: "AP3Aase activity" EXACT [EC:3.6.1.29] synonym: "diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity" EXACT [EC:3.6.1.29] synonym: "diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity" EXACT [EC:3.6.1.29] synonym: "diadenosine 5,5-P1,P3-triphosphatase activity" EXACT [EC:3.6.1.29] synonym: "dinucleosidetriphosphatase activity" EXACT [EC:3.6.1.29] synonym: "P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29] xref: EC:3.6.1.29 xref: GO:0047710 xref: MetaCyc:BIS(5 is_a: CCO:F0000937 ! nucleotide diphosphatase activity [Term] id: CCO:F0007013 name: blasticidin-S deaminase activity namespace: molecular_function def: "Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3." [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN] subset: gosubset_prok synonym: "blasticidin-S aminohydrolase activity" EXACT [EC:3.5.4.23] xref: EC:3.5.4.23 xref: GO:0047711 xref: MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0007014 name: Cypridina-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN] synonym: "Cypridina luciferase activity" EXACT [EC:1.13.12.6] synonym: "Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.6] synonym: "Cypridina-type luciferase activity" EXACT [EC:1.13.12.6] synonym: "cypridina-type luciferase activity" EXACT [EC:1.13.12.6] synonym: "luciferase (Cypridina luciferin)" EXACT [EC:1.13.12.6] synonym: "luciferase activity" BROAD [EC:1.13.12.6] xref: EC:1.13.12.6 xref: GO:0047712 xref: MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: CCO:F0006100 ! luciferin monooxygenase activity [Term] id: CCO:F0007015 name: galactitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: galactitol + NAD+ = D-tagatose + NADH." [EC:1.1.1.16, MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN] xref: EC:1.1.1.16 xref: GO:0047713 xref: MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: CCO:F0004651 ! hexitol dehydrogenase activity [Term] id: CCO:F0007016 name: galactolipase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates." [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN] synonym: "1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity" EXACT [EC:3.1.1.26] synonym: "galactolipid acylhydrolase activity" EXACT [EC:3.1.1.26] synonym: "galactolipid lipase activity" EXACT [EC:3.1.1.26] synonym: "polygalactolipase activity" EXACT [EC:3.1.1.26] xref: EC:3.1.1.26 xref: GO:0047714 xref: MetaCyc:GALACTOLIPASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0003111 ! lipase activity [Term] id: CCO:F0007017 name: hypotaurocyamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: hypotaurocyamine + ATP = N(omega)-phosphohypotaurocyamine + ADP." [EC:2.7.3.6, MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN] synonym: "ATP:hypotaurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.6] xref: EC:2.7.3.6 xref: GO:0047715 xref: MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0007018 name: imidazole N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + imidazole = CoA + N-acetylimidazole." [EC:2.3.1.2, MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:imidazole N-acetyltransferase activity" EXACT [EC:2.3.1.2] synonym: "imidazole acetylase activity" EXACT [EC:2.3.1.2] synonym: "imidazole acetyltransferase activity" EXACT [EC:2.3.1.2] xref: EC:2.3.1.2 xref: GO:0047716 xref: MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0007019 name: imidazoleacetate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-imidazoleacetate + NADH + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O." [EC:1.14.13.5, MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN] synonym: "4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.13.5] synonym: "imidazoleacetate hydroxylase activity" EXACT [EC:1.14.13.5] synonym: "imidazoleacetic hydroxylase activity" EXACT [] synonym: "imidazoleacetic monooxygenase activity" EXACT [EC:1.14.13.5] xref: EC:1.14.13.5 xref: GO:0047717 xref: MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007020 name: indanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+." [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN] synonym: "indan-1-ol:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.112] xref: EC:1.1.1.112 xref: GO:0047718 xref: MetaCyc:INDANOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007021 name: indole 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: indole + O2 = 2-formylaminobenzaldehyde." [EC:1.13.11.17, MetaCyc:INDOLE-2] synonym: "IDO" RELATED [EC:1.13.11.17] synonym: "indole oxidase activity" EXACT [EC:1.13.11.17] synonym: "indole-oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17] synonym: "indole:O2 oxidoreductase activity" EXACT [EC:1.13.11.17] synonym: "indole:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17] xref: EC:1.13.11.17 xref: GO:0047719 xref: MetaCyc:INDOLE-2 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007022 name: indoleacetaldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetaldoxime = indole-3-acetonitrile + H2O." [EC:4.2.1.29, MetaCyc:INDOLEACETALDOXIME-DEHYDRATASE-RXN] synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]" RELATED [EC:4.99.1.6] synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "3-indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "indole-3-acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "indole-3-acetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] xref: EC:4.99.1.6 xref: GO:0047720 xref: MetaCyc:RXN-1403 is_a: CCO:F0003396 ! lyase activity [Term] id: CCO:F0007023 name: indoleacetate-lysine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + indoleacetate + L-lysine = ADP + phosphate + N6-[(indole-3-yl)acetyl]-L-lysine." [EC:6.3.2.20, MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN] subset: gosubset_prok synonym: "(indol-3-yl)acetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20] synonym: "IAA-lysine synthetase activity" EXACT [EC:6.3.2.20] synonym: "indoleacetate-lysine ligase activity" EXACT [] synonym: "indoleacetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20] synonym: "N-(indole-3-acetyl)-L-lysine synthetase activity" EXACT [EC:6.3.2.20] xref: EC:6.3.2.20 xref: GO:0047721 xref: MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0007024 name: indolelactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: indolelactate + NAD+ = indolepyruvate + NADH." [EC:1.1.1.110, MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN] synonym: "(indol-3-yl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110] synonym: "indole-3-lactate dehydrogenase activity" EXACT [] synonym: "indolelactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110] xref: EC:1.1.1.110 xref: GO:0047722 xref: MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007025 name: inosinate nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-inosinate + H2O = D-ribose 5-phosphate + hypoxanthine." [EC:3.2.2.12, MetaCyc:INOSINATE-NUCLEOSIDASE-RXN] synonym: "5'-inosinate phosphoribohydrolase activity" EXACT [EC:3.2.2.12] xref: EC:3.2.2.12 xref: GO:0047723 xref: MetaCyc:INOSINATE-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0007026 name: inosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine." [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN] synonym: "inosinase activity" EXACT [EC:3.2.2.2] synonym: "inosine ribohydrolase activity" EXACT [EC:3.2.2.2] synonym: "inosine-guanosine nucleosidase activity" EXACT [EC:3.2.2.2] xref: EC:3.2.2.2 xref: GO:0047724 xref: MetaCyc:INOSINE-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0007027 name: inulosucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)." [EC:2.4.1.9, MetaCyc:INULOSUCRASE-RXN] subset: gosubset_prok synonym: "sucrose 1-fructosyl transferase activity" EXACT [EC:2.4.1.9] synonym: "sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.9] synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.9] xref: EC:2.4.1.9 xref: GO:0047725 xref: MetaCyc:INULOSUCRASE-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0007028 name: iron-cytochrome-c reductase activity namespace: molecular_function def: "Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+." [EC:1.9.99.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN] synonym: "ferrocytochrome-c:Fe3+ oxidoreductase activity" EXACT [EC:1.9.99.1] synonym: "iron-cytochrome c reductase activity" EXACT [EC:1.9.99.1] xref: EC:1.9.99.1 xref: GO:0047726 xref: MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN is_a: CCO:F0003267 ! oxidoreductase activity, acting on heme group of donors [Term] id: CCO:F0007029 name: isobutyryl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylpropanoyl-CoA = butanoyl-CoA." [EC:5.4.99.13, MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN] subset: gosubset_prok synonym: "2-methylpropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.13] synonym: "butyryl-CoA:isobutyryl-CoA mutase activity" EXACT [EC:5.4.99.13] synonym: "isobutyryl coenzyme A mutase activity" EXACT [EC:5.4.99.13] xref: EC:5.4.99.13 xref: GO:0047727 xref: MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0007030 name: carnitine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + L-carnitine = NADH + 3-dehydrocarnitine." [EC:1.1.1.108, MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "carnitine:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.108] xref: EC:1.1.1.108 xref: GO:0047728 xref: MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007031 name: carnitine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: carnitine = 2-methylcholine + CO2." [EC:4.1.1.42, MetaCyc:CARNITINE-DECARBOXYLASE-RXN] synonym: "carnitine carboxy-lyase (2-methylcholine-forming)" EXACT [EC:4.1.1.42] synonym: "carnitine carboxy-lyase activity" EXACT [EC:4.1.1.42] xref: EC:4.1.1.42 xref: GO:0047729 xref: MetaCyc:CARNITINE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007032 name: carnosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine." [EC:6.3.2.11, MetaCyc:CARNOSINE-SYNTHASE-RXN] synonym: "carnosine synthetase activity" EXACT [EC:6.3.2.11] synonym: "carnosine-anserine synthetase activity" EXACT [EC:6.3.2.11] synonym: "carnosine-homocarnosine synthetase activity" EXACT [EC:6.3.2.11] synonym: "homocarnosine-carnosine synthetase activity" EXACT [EC:6.3.2.11] synonym: "L-histidine:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.11] xref: EC:6.3.2.11 xref: GO:0047730 xref: MetaCyc:CARNOSINE-SYNTHASE-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0007033 name: catechol oxidase (dimerizing) activity namespace: molecular_function def: "Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O." [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-(DIMERIZING)-RXN] synonym: "catechol:oxygen oxidoreductase (dimerizing)" EXACT [EC:1.1.3.14] xref: EC:1.1.3.14 xref: GO:0047731 xref: MetaCyc:CATECHOL-OXIDASE-(DIMERIZING)-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007034 name: CDP-abequose epimerase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose." [EC:5.1.3.10, MetaCyc:CDP-ABEQUOSE-EPIMERASE-RXN] synonym: "CDP-3,6-dideoxy-D-glucose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-D-abequose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-paratose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-paratose epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-tyvelose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphate paratose-2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphoabequose epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphodideoxyglucose epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphoparatose epimerase activity" EXACT [EC:5.1.3.10] xref: EC:5.1.3.10 xref: GO:0047732 xref: MetaCyc:CDP-ABEQUOSE-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007035 name: CDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.45, MetaCyc:CDP-GLUCOSE-4] subset: gosubset_prok synonym: "CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.45] synonym: "CDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45] synonym: "CDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.45] synonym: "CDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45] synonym: "cytidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.45] xref: EC:4.2.1.45 xref: GO:0047733 xref: MetaCyc:CDP-GLUCOSE-4 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007036 name: CDP-glycerol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate." [EC:3.6.1.16, MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN] synonym: "CDP-glycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16] synonym: "CDP-glycerol pyrophosphatase activity" EXACT [] synonym: "CDPglycerol diphosphatase activity" EXACT [EC:3.6.1.16] synonym: "CDPglycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16] synonym: "CDPglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16] synonym: "cytidine diphosphoglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16] xref: EC:3.6.1.16 xref: GO:0047734 xref: MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0007037 name: cellobiose dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor." [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-(ACCEPTOR)-RXN] synonym: "CBOR activity" RELATED [EC:1.1.99.18] synonym: "CDH activity" RELATED [EC:1.1.99.18] synonym: "cellobiose dehydrogenase (quinone) activity" NARROW [EC:1.1.99.18] synonym: "cellobiose dehydrogenase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose oxidase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose-quinone oxidoreductase activity" NARROW [EC:1.1.99.18] synonym: "cellobiose:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "phanerochaete chrysosporium cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18] xref: EC:1.1.99.18 xref: GO:0047735 xref: GO:0047737 xref: MetaCyc:CELLOBIOSE-DEHYDROGENASE-(ACCEPTOR)-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007038 name: cellobiose epimerase activity namespace: molecular_function def: "Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose." [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN] synonym: "cellobiose 2-epimerase activity" EXACT [EC:5.1.3.11] xref: EC:5.1.3.11 xref: GO:0047736 xref: MetaCyc:CELLOBIOSE-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007039 name: cellobiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.20, MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN] subset: gosubset_prok synonym: "cellobiose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.20] xref: EC:2.4.1.20 xref: GO:0047738 xref: MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0007040 name: cephalosporin-C deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: cephalosporin C + H2O = deacetylcephalosporin C + acetate." [EC:3.1.1.41, MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN] subset: gosubset_prok synonym: "cephalosporin acetylesterase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetyl-esterase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetyl-hydrolase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetylase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetylesterase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C deacetylase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin-C acetylhydrolase activity" EXACT [EC:3.1.1.41] xref: EC:3.1.1.41 xref: GO:0047739 xref: MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0007041 name: cephalosporin-C transaminase activity namespace: molecular_function def: "Catalysis of the reaction: cephalosporin C + pyruvate = 7-(5-carboxyl-5-oxopentanyl)-aminocephalosporinate + L-alanine." [EC:2.6.1.74, MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN] synonym: "cephalosporin C aminotransferase activity" EXACT [EC:2.6.1.74] synonym: "cephalosporin-C:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.74] synonym: "L-alanine:cephalosporin-C aminotransferase activity" EXACT [EC:2.6.1.74] xref: EC:2.6.1.74 xref: GO:0047740 xref: MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007042 name: cetraxate benzylesterase activity namespace: molecular_function def: "Catalysis of the reaction: cetraxate benzyl ester + H2O = cetraxate + benzyl alcohol." [EC:3.1.1.70, MetaCyc:CETRAXATE-BENZYLESTERASE-RXN] synonym: "cetraxate-benzyl-ester benzylhydrolase activity" EXACT [EC:3.1.1.70] xref: EC:3.1.1.70 xref: GO:0047741 xref: MetaCyc:CETRAXATE-BENZYLESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007043 name: chenodeoxycholoyltaurine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine." [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN] synonym: "chenodeoxycholoyltaurine amidohydrolase activity" EXACT [EC:3.5.1.74] xref: EC:3.5.1.74 xref: GO:0047742 xref: MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007044 name: chlordecone reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + NADPH." [EC:1.1.1.225, MetaCyc:CHLORDECONE-REDUCTASE-RXN] synonym: "CDR activity" RELATED [EC:1.1.1.225] synonym: "chlordecone-alcohol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.225] xref: EC:1.1.1.225 xref: GO:0047743 xref: MetaCyc:CHLORDECONE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007045 name: chloridazon-catechol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone." [EC:1.13.11.36, MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN] synonym: "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.36] xref: EC:1.13.11.36 xref: GO:0047744 xref: MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007046 name: chlorogenate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: chlorogenate + H2O = caffeate + quinate." [EC:3.1.1.42, MetaCyc:CHLOROGENATE-HYDROLASE-RXN] synonym: "chlorogenase activity" EXACT [EC:3.1.1.42] synonym: "chlorogenic acid esterase activity" EXACT [EC:3.1.1.42] xref: EC:3.1.1.42 xref: GO:0047745 xref: MetaCyc:CHLOROGENATE-HYDROLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007047 name: chlorophyllase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide." [EC:3.1.1.14, MetaCyc:CHLOROPHYLLASE-RXN] synonym: "chlorophyll chlorophyllidohydrolase activity" EXACT [EC:3.1.1.14] xref: EC:3.1.1.14 xref: GO:0047746 xref: MetaCyc:CHLOROPHYLLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007048 name: cholate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7, MetaCyc:CHOLATE--COA-LIGASE-RXN] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity" EXACT [] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] synonym: "BAL activity" RELATED [EC:6.2.1.29] synonym: "bile acid CoA ligase activity" RELATED [EC:6.2.1.29] synonym: "bile acid coenzyme A ligase activity" RELATED [EC:6.2.1.29] synonym: "cholate thiokinase activity" EXACT [EC:6.2.1.29] synonym: "cholate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29] synonym: "cholic acid:CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "cholic thiokinase activity" EXACT [EC:6.2.1.29] synonym: "choloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] synonym: "choloyl-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "cholyl-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "THCA-CoA ligase activity" RELATED [EC:6.2.1.29] synonym: "trihydroxycoprostanoyl-CoA synthetase activity" RELATED [EC:6.2.1.29] xref: EC:6.2.1.29 xref: EC:6.2.1.7 xref: GO:0047477 xref: GO:0047747 xref: MetaCyc:6.2.1.29-RXN xref: MetaCyc:CHOLATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007049 name: cholestanetetraol 26-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [EC:1.1.1.161, MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN] synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT [EC:1.1.1.161] synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT [EC:1.1.1.161] synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT [EC:1.1.1.161] synonym: "TEHC-NAD oxidoreductase activity" EXACT [EC:1.1.1.161] xref: EC:1.1.1.161 xref: GO:0047748 xref: MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007050 name: cholestanetriol 26-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O." [EC:1.14.13.15, MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN] synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15] synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity" BROAD [EC:1.14.13.15] synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15] synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity" EXACT [EC:1.14.13.15] synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)" EXACT [EC:1.14.13.15] synonym: "cholestanetriol 26-hydroxylase activity" EXACT [] synonym: "cholesterol 27-hydroxylase activity" RELATED [EC:1.14.13.15] synonym: "CYP27A" RELATED [EC:1.14.13.15] synonym: "CYP27A1" RELATED [EC:1.14.13.15] synonym: "cytochrome P450 27A1' activity" NARROW [EC:1.14.13.15] synonym: "sterol 26-hydroxylase activity" BROAD [EC:1.14.13.15] synonym: "sterol 27-hydroxylase activity" RELATED [EC:1.14.13.15] xref: EC:1.14.13.15 xref: GO:0047749 xref: MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007051 name: cholestenol delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [EC:5.3.3.5, MetaCyc:CHOLESTENOL-DELTA-ISOMERASE-RXN] synonym: "cholestenol D-isomerase activity" EXACT [] synonym: "delta7-cholestenol delta7-delta8-isomerase activity" EXACT [EC:5.3.3.5] xref: EC:5.3.3.5 xref: GO:0047750 xref: MetaCyc:CHOLESTENOL-DELTA-ISOMERASE-RXN is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0007052 name: cholestenone 5-alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH." [EC:1.3.1.22, MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN] synonym: "3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.22] synonym: "3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.1.22] synonym: "4-ene-3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "4-ene-5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "5alpha-reductase" BROAD [EC:1.3.1.22] synonym: "cholest-4-en-3-one 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "cholestenone 5a-reductase activity" EXACT [] synonym: "cholestenone 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22] synonym: "reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22] synonym: "steroid 5alpha-hydrogenase activity" EXACT [EC:1.3.1.22] synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.1.22] synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.1.22] synonym: "testosterone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "testosterone delta4-hydrogenase activity" EXACT [EC:1.3.1.22] xref: EC:1.3.1.22 xref: GO:0047751 xref: MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007053 name: choline-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: choline sulfate + H2O = choline + sulfate." [EC:3.1.6.6, MetaCyc:CHOLINE-SULFATASE-RXN] subset: gosubset_prok synonym: "choline-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.6] synonym: "choline-sulphatase activity" EXACT [] xref: EC:3.1.6.6 xref: GO:0047753 xref: MetaCyc:CHOLINE-SULFATASE-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0007054 name: choline sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate." [EC:2.8.2.6, MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:choline sulfotransferase activity" EXACT [EC:2.8.2.6] synonym: "choline sulphokinase activity" EXACT [EC:2.8.2.6] synonym: "choline sulphotransferase activity" EXACT [] xref: EC:2.8.2.6 xref: GO:0047754 xref: MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007055 name: isocitrate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate = (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate." [EC:5.1.2.6, MetaCyc:ISOCITRATE-EPIMERASE-RXN] synonym: "(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity" EXACT [EC:5.1.2.6] xref: EC:5.1.2.6 xref: GO:0047755 xref: MetaCyc:ISOCITRATE-EPIMERASE-RXN is_a: CCO:F0003419 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: CCO:F0007056 name: chondroitin 4-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate." [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity" EXACT [EC:2.8.2.5] synonym: "chondroitin 4-sulphotransferase activity" EXACT [] synonym: "chondroitin sulfotransferase activity" EXACT [EC:2.8.2.5] xref: EC:2.8.2.5 xref: GO:0047756 xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007057 name: chondroitin-glucuronate 5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN] synonym: "chondroitin D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.19] synonym: "chondroitin-D-glucuronate 5-epimerase activity" EXACT [EC:5.1.3.19] synonym: "dermatan-sulfate 5-epimerase activity" EXACT [EC:5.1.3.19] synonym: "polyglucuronate 5-epimerase activity" RELATED [EC:5.1.3.19] synonym: "urunosyl C-5 epimerase activity" EXACT [EC:5.1.3.19] xref: EC:5.1.3.19 xref: GO:0047757 xref: MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007058 name: branched-chain fatty acid kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-methylpropanoate = ADP + 2-methylpropanoyl phosphate." [EC:2.7.2.14, MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN] synonym: "ATP:branched-chain-fatty-acid 1-phosphotransferase activity" EXACT [EC:2.7.2.14] synonym: "branched-chain-fatty-acid kinase activity" EXACT [] synonym: "isobutyrate kinase activity" NARROW [EC:2.7.2.14] xref: EC:2.7.2.14 xref: GO:0047758 xref: MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0007059 name: butanal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+." [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN] synonym: "butanal:NAD(P)+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.57] xref: EC:1.2.1.57 xref: GO:0047759 xref: MetaCyc:BUTANAL-DEHYDROGENASE-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007060 name: butyrate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA." [EC:6.2.1.2, MetaCyc:BUTYRATE--COA-LIGASE-RXN] synonym: "acyl-activating enzyme activity" RELATED [EC:6.2.1.2] synonym: "butanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.2] synonym: "butyryl-CoA synthetase activity" EXACT [EC:6.2.1.2] synonym: "butyryl-coenzyme A synthetase activity" EXACT [EC:6.2.1.2] synonym: "fatty acid activating enzyme" RELATED [EC:6.2.1.2] synonym: "fatty acid thiokinase (medium chain) activity" RELATED [EC:6.2.1.2] synonym: "fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.2] synonym: "L-(+)-3-hydroxybutyryl CoA ligase activity" EXACT [EC:6.2.1.2] synonym: "medium chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2] synonym: "short-chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2] xref: EC:6.2.1.2 xref: GO:0047760 xref: MetaCyc:BUTYRATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007061 name: butyrate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate." [EC:2.7.2.7, MetaCyc:BUTYRATE-KINASE-RXN] subset: gosubset_prok synonym: "ATP:butanoate 1-phosphotransferase activity" EXACT [EC:2.7.2.7] xref: EC:2.7.2.7 xref: GO:0047761 xref: MetaCyc:BUTYRATE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0007062 name: caffeate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-trans-cinnamate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate." [EC:1.13.11.22, MetaCyc:CAFFEATE-3] synonym: "3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.22] xref: EC:1.13.11.22 xref: GO:0047762 xref: MetaCyc:CAFFEATE-3 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007063 name: caffeate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate." [EC:2.1.1.68, MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN] synonym: "caffeate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68] synonym: "caffeate methyltransferase activity" EXACT [EC:2.1.1.68] synonym: "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68] synonym: "S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity" EXACT [EC:2.1.1.68] xref: EC:2.1.1.68 xref: GO:0047763 xref: MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN is_a: CCO:F0001758 ! O-methyltransferase activity [Term] id: CCO:F0007064 name: caldesmon kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate." [GOC:curators] xref: GO:0047764 is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0007065 name: caldesmon-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate." [EC:3.1.3.55, MetaCyc:CALDESMON-PHOSPHATASE-RXN] synonym: "caldesmon-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.55] synonym: "smooth muscle caldesmon phosphatase activity" EXACT [EC:3.1.3.55] synonym: "SMP-I" RELATED [EC:3.1.3.55] xref: EC:3.1.3.55 xref: GO:0047765 xref: MetaCyc:CALDESMON-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007066 name: carbamoyl-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: O-carbamoyl-L-serine + H2O = pyruvate + 2 NH3 + CO2." [EC:4.3.1.13, MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN] synonym: "carbamoylserine deaminase activity" EXACT [EC:4.3.1.13] synonym: "O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)" EXACT [EC:4.3.1.13] synonym: "O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.13] synonym: "O-carbamoyl-L-serine deaminase activity" EXACT [EC:4.3.1.13] xref: EC:4.3.1.13 xref: GO:0047766 xref: MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0007067 name: carboxy-cis,cis-muconate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.5, MetaCyc:CARBOXY-CIS] synonym: "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.5] synonym: "3-carboxy-cis,cis-muconate lactonizing enzyme activity" EXACT [EC:5.5.1.5] synonym: "3-carboxymuconate cyclase activity" EXACT [EC:5.5.1.5] xref: EC:5.5.1.5 xref: GO:0047768 xref: MetaCyc:CARBOXY-CIS is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0007068 name: arogenate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2." [EC:4.2.1.91, MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN] subset: gosubset_prok synonym: "carboxycyclohexadienyl dehydratase activity" EXACT [] synonym: "L-arogenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.91] synonym: "L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)" EXACT [EC:4.2.1.91] xref: EC:4.2.1.91 xref: GO:0047769 xref: MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007069 name: carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor." [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN] synonym: "aldehyde:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.6] synonym: "aldehyde:acceptor oxidoreductase activity" EXACT [EC:1.2.99.6] synonym: "carboxylic acid reductase activity" EXACT [EC:1.2.99.6] xref: EC:1.2.99.6 xref: GO:0047770 xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0007070 name: carboxymethylhydantoinase activity namespace: molecular_function def: "Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate." [EC:3.5.2.4, MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN] synonym: "hydantoin hydrolase activity" EXACT [EC:3.5.2.4] synonym: "L-5-carboxymethylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.4] xref: EC:3.5.2.4 xref: GO:0047771 xref: MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0007071 name: carboxymethyloxysuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 2 carboxymethyloxysuccinate = 2 glycolate + 2 fumarate." [EC:4.2.99.12, MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN] synonym: "carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)" EXACT [EC:4.2.99.12] synonym: "carboxymethyloxysuccinate glycolate-lyase activity" EXACT [EC:4.2.99.12] xref: EC:4.2.99.12 xref: GO:0047772 xref: MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN is_a: CCO:F0003401 ! carbon-oxygen lyase activity [Term] id: CCO:F0007072 name: carnitinamidase activity namespace: molecular_function def: "Catalysis of the reaction: L-carnitinamide + H2O = L-carnitine + NH3." [EC:3.5.1.73, MetaCyc:CARNITINAMIDASE-RXN] synonym: "carnitine amidase activity" EXACT [EC:3.5.1.73] synonym: "L-carnitinamidase activity" EXACT [EC:3.5.1.73] synonym: "L-carnitinamide amidohydrolase activity" EXACT [EC:3.5.1.73] synonym: "L-carnitine amidase activity" EXACT [EC:3.5.1.73] xref: EC:3.5.1.73 xref: GO:0047773 xref: MetaCyc:CARNITINAMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007073 name: cis-2-enoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH." [EC:1.3.1.37, MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-(NADPH)-RXN] synonym: "acyl-CoA:NADP+ cis-2-oxidoreductase activity" EXACT [EC:1.3.1.37] synonym: "cis-2-enoyl-coenzyme A reductase activity" EXACT [EC:1.3.1.37] synonym: "NADPH-dependent cis-enoyl-CoA reductase activity" EXACT [EC:1.3.1.37] synonym: "reductase, cis-2-enoyl coenzyme A" EXACT [EC:1.3.1.37] xref: EC:1.3.1.37 xref: GO:0047774 xref: MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-(NADPH)-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007074 name: citramalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA." [EC:2.8.3.11, MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN] synonym: "acetyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.11] xref: EC:2.8.3.11 xref: GO:0047775 xref: MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0007075 name: citramalate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-citramalate = acetate + pyruvate." [EC:4.1.3.22, MetaCyc:CITRAMALATE-LYASE-RXN] synonym: "(+)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] synonym: "(3S)-citramalate pyruvate-lyase (acetate-forming)" EXACT [EC:4.1.3.22] synonym: "(3S)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] synonym: "(S)-citramalate lyase activity" EXACT [EC:4.1.3.22] synonym: "citramalate pyruvate lyase activity" EXACT [EC:4.1.3.22] synonym: "citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] synonym: "citramalate synthetase activity" EXACT [EC:4.1.3.22] synonym: "citramalic synthase activity" EXACT [EC:4.1.3.22] synonym: "citramalic-condensing enzyme" RELATED [EC:4.1.3.22] xref: EC:4.1.3.22 xref: GO:0047776 xref: MetaCyc:CITRAMALATE-LYASE-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0007076 name: citramalyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate." [EC:4.1.3.25, MetaCyc:CITRAMALYL-COA-LYASE-RXN] synonym: "(+)-CMA-CoA lyase activity" EXACT [EC:4.1.3.25] synonym: "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.25] synonym: "(3S)-citramalyl-CoA pyruvate-lyase activity" EXACT [EC:4.1.3.25] synonym: "citramalyl coenzyme A lyase activity" EXACT [EC:4.1.3.25] xref: EC:4.1.3.25 xref: GO:0047777 xref: MetaCyc:CITRAMALYL-COA-LYASE-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0007078 name: citrate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA." [EC:6.2.1.18, MetaCyc:CITRATE--COA-LIGASE-RXN] synonym: "citrate thiokinase activity" EXACT [EC:6.2.1.18] synonym: "citrate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.18] synonym: "citrate:CoA ligase activity" EXACT [EC:6.2.1.18] synonym: "citryl-CoA synthetase activity" EXACT [EC:6.2.1.18] xref: EC:6.2.1.18 xref: GO:0047779 xref: MetaCyc:CITRATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007079 name: citrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = cis-aconitate + H2O." [EC:4.2.1.4, MetaCyc:CITRATE-DEHYDRATASE-RXN] synonym: "citrate hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.4] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.4] xref: EC:4.2.1.4 xref: GO:0047780 xref: MetaCyc:CITRATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007080 name: citrullinase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine." [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN] synonym: "citrulline hydrolase activity" EXACT [EC:3.5.1.20] synonym: "citrulline ureidase activity" EXACT [EC:3.5.1.20] synonym: "L-citrulline 5-N-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20] synonym: "L-citrulline N5-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20] xref: EC:3.5.1.20 xref: GO:0047781 xref: MetaCyc:CITRULLINASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007081 name: coniferin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol." [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN] synonym: "coniferin b-glucosidase activity" EXACT [] synonym: "coniferin beta-D-glucosidase activity" EXACT [EC:3.2.1.126] synonym: "coniferin-hydrolyzing beta-glucosidase activity" EXACT [EC:3.2.1.126] xref: EC:3.2.1.126 xref: GO:0047782 xref: MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007082 name: corticosterone 18-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.5, MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN] synonym: "corticosterone 18-hydroxylase activity" EXACT [] synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5] synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" EXACT [EC:1.14.15.5] xref: EC:1.14.15.5 xref: GO:0047783 xref: MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN is_a: CCO:F0003296 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007083 name: cortisol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate." [EC:2.3.1.27, MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:cortisol O-acetyltransferase activity" EXACT [EC:2.3.1.27] synonym: "corticosteroid acetyltransferase activity" EXACT [EC:2.3.1.27] synonym: "corticosteroid-21-O-acetyltransferase activity" EXACT [EC:2.3.1.27] synonym: "cortisol acetyltransferase activity" EXACT [EC:2.3.1.27] xref: EC:2.3.1.27 xref: GO:0047784 xref: MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0007084 name: cortisol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate." [EC:2.8.2.18, MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity" EXACT [EC:2.8.2.18] synonym: "cortisol sulphotransferase activity" EXACT [] synonym: "glucocorticoid sulfotransferase activity" EXACT [EC:2.8.2.18] synonym: "glucocorticosteroid sulfotransferase activity" BROAD [EC:2.8.2.18] xref: EC:2.8.2.18 xref: GO:0047785 xref: MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007085 name: cortisone alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-alpha-dihydrocortisone + NADP+ = cortisone + NADPH." [EC:1.3.1.4, MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN] synonym: "4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.4] synonym: "cortisone a-reductase activity" EXACT [] synonym: "cortisone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4] synonym: "delta4-3-ketosteroid reductase (5alpha)" EXACT [EC:1.3.1.4] synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.1.4] synonym: "delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4] synonym: "microsomal steroid reductase (5alpha)" EXACT [EC:1.3.1.4] synonym: "NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.1.4] xref: EC:1.3.1.4 xref: GO:0047786 xref: MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007086 name: delta4-3-oxosteroid 5beta-reductase activity namespace: molecular_function def: "Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+." [EC:1.3.1.3, MetaCyc:CORTISONE-BETA-REDUCTASE-RXN] synonym: "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23] synonym: "3-oxo-Delta(4)-steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "3-oxo-delta4-steroid 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23] synonym: "5-beta-reductase activity" BROAD [EC:1.3.1.23] synonym: "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity" EXACT [EC:1.3.1.23] synonym: "5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "androstenedione 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "androstenedione 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cholestenone 5-beta-reductase activity" EXACT [] synonym: "cholestenone 5b-reductase activity" EXACT [] synonym: "cholestenone 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone b-reductase activity" EXACT [] synonym: "cortisone beta-reductase activity" EXACT [] synonym: "cortisone delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone delta4-5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta(4)-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta(4)-hydrogenase activity" EXACT [EC:1.3.1.23] synonym: "delta-4-3-oxosteroid 5-beta-reductase activity" EXACT [] synonym: "delta4-3-ketosteroid 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta4-5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta4-hydrogenase activity" EXACT [EC:1.3.1.23] synonym: "steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "steroid 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "testosterone 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "testosterone 5beta-reductase activity" EXACT [EC:1.3.1.23] xref: EC:1.3.1.3 xref: GO:0047752 xref: GO:0047787 xref: MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN xref: MetaCyc:CORTISONE-BETA-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007087 name: 2-coumarate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = 2-coumarate + NADH." [EC:1.3.1.11, MetaCyc:COUMARATE-REDUCTASE-RXN] synonym: "3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.11] synonym: "coumarate reductase activity" EXACT [] synonym: "melilotate dehydrogenase activity" EXACT [EC:1.3.1.11] xref: EC:1.3.1.11 xref: GO:0047788 xref: MetaCyc:COUMARATE-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007088 name: creatininase activity namespace: molecular_function def: "Catalysis of the reaction: creatinine + H2O = creatine." [EC:3.5.2.10, MetaCyc:CREATININASE-RXN] subset: gosubset_prok synonym: "creatinine amidohydrolase activity" EXACT [EC:3.5.2.10] synonym: "creatinine hydrolase" BROAD [EC:3.5.2.10] xref: EC:3.5.2.10 xref: GO:0047789 xref: MetaCyc:CREATININASE-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0007089 name: creatinine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3." [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN] subset: gosubset_prok synonym: "creatinine desiminase activity" EXACT [EC:3.5.4.21] synonym: "creatinine hydrolase" BROAD [EC:3.5.4.21] synonym: "creatinine iminohydrolase activity" EXACT [EC:3.5.4.21] xref: EC:3.5.4.21 xref: GO:0047790 xref: MetaCyc:CREATININE-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0007090 name: cucurbitacin delta23-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+." [EC:1.3.1.5, MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN] synonym: "23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity" EXACT [EC:1.3.1.5] synonym: "cucurbitacin D23-reductase activity" EXACT [] synonym: "cucurbitacin delta(23) reductase activity" EXACT [] synonym: "NAD(P)H: cucurbitacin B delta23-oxidoreductase activity" EXACT [EC:1.3.1.5] xref: EC:1.3.1.5 xref: GO:0047791 xref: MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007091 name: cyanohydrin beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDPglucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside." [EC:2.4.1.85, MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "cyanohydrin b-glucosyltransferase activity" EXACT [] synonym: "UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UGT85B1 activity" NARROW [EC:2.4.1.85] synonym: "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.85] xref: EC:2.4.1.85 xref: GO:0047792 xref: MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007092 name: cycloeucalenol cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: cycloeucalenol = obtusifoliol." [EC:5.5.1.9, MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN] synonym: "cycloeucalenol lyase (cyclopropane-decyclizing)" EXACT [EC:5.5.1.9] synonym: "cycloeucalenol--obtusifoliol isomerase activity" EXACT [EC:5.5.1.9] synonym: "cycloeucalenol-obtusifoliol isomerase activity" EXACT [] xref: EC:5.5.1.9 xref: GO:0047793 xref: MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0007093 name: cyclohexadienyl dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2." [EC:1.3.1.43, MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "arogenate dehydrogenase activity" EXACT [EC:1.3.1.43] synonym: "arogenic dehydrogenase activity" EXACT [EC:1.3.1.43] synonym: "L-arogenate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.43] synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.43] synonym: "L-arogenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.43] synonym: "pretyrosine dehydrogenase activity" EXACT [EC:1.3.1.43] xref: EC:1.3.1.43 xref: GO:0047794 xref: MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007094 name: cyclohexane-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH." [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-1] synonym: "trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.174] xref: EC:1.1.1.174 xref: GO:0047795 xref: MetaCyc:CYCLOHEXANE-1 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007095 name: cyclohexane-1,3-dione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexane-1,3-dione + H2O = 5-oxohexanoate." [EC:3.7.1.10, MetaCyc:CYCLOHEXANE-1] synonym: "1,3-cyclohexanedione hydrolase activity" EXACT [EC:3.7.1.10] synonym: "cyclohexane-1,3-dione acylhydrolase (decyclizing)" EXACT [EC:3.7.1.10] xref: EC:3.7.1.10 xref: GO:0047796 xref: MetaCyc:CYCLOHEXANE-1 is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0007096 name: cyclohexanone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexanone + acceptor = cyclohex-2-enone + reduced acceptor." [EC:1.3.99.14, MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN] synonym: "cyclohexanone:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.3.99.14] synonym: "cyclohexanone:acceptor 2-oxidoreductase activity" EXACT [EC:1.3.99.14] xref: EC:1.3.99.14 xref: GO:0047797 xref: MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0007097 name: cyclomaltodextrinase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin." [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN] subset: gosubset_prok synonym: "cyclodextrinase activity" EXACT [EC:3.2.1.54] synonym: "cycloheptaglucanase activity" EXACT [EC:3.2.1.54] synonym: "cyclohexaglucanase activity" EXACT [EC:3.2.1.54] synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" EXACT [EC:3.2.1.54] xref: EC:3.2.1.54 xref: GO:0047798 xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007098 name: cyclopentanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopentanone + NADPH + O2 = 5-valerolactone + NADP+ + H2O." [EC:1.14.13.16, MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN] synonym: "cyclopentanone 1,2-monooxygenase activity" EXACT [EC:1.14.13.16] synonym: "cyclopentanone oxygenase activity" EXACT [EC:1.14.13.16] synonym: "cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)" EXACT [EC:1.14.13.16] xref: EC:1.14.13.16 xref: GO:0047799 xref: MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007099 name: cysteamine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cysteamine + O2 = hypotaurine." [EC:1.13.11.19, MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN] synonym: "2-aminoethanethiol:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19] synonym: "cysteamine oxygenase activity" EXACT [EC:1.13.11.19] synonym: "cysteamine:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19] synonym: "persulfurase activity" RELATED [EC:1.13.11.19] xref: EC:1.13.11.19 xref: GO:0047800 xref: MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007100 name: cysteine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate." [EC:2.6.1.3, MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN] synonym: "CGT" RELATED [EC:2.6.1.3] synonym: "cysteine aminotransferase activity" EXACT [] synonym: "L-cysteine aminotransferase activity" EXACT [EC:2.6.1.3] synonym: "L-cysteine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.3] xref: EC:2.6.1.3 xref: GO:0047801 xref: MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007101 name: cysteine-conjugate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate = S-(4-bromophenyl)-mercaptopyruvate + L-glutamate." [EC:2.6.1.75, MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN] synonym: "cysteine conjugate aminotransferase activity" EXACT [EC:2.6.1.75] synonym: "cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)" EXACT [EC:2.6.1.75] synonym: "S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.75] xref: EC:2.6.1.75 xref: GO:0047802 xref: MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007102 name: cysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + SO3(2-) (sulfite) = L-cysteate + sulfide." [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN] synonym: "cysteine (sulfite) lyase activity" EXACT [EC:4.4.1.10] synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite)" EXACT [EC:4.4.1.10] synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)" EXACT [EC:4.4.1.10] xref: EC:4.4.1.10 xref: GO:0047803 xref: MetaCyc:CYSTEINE-LYASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0007103 name: cysteine-S-conjugate beta-lyase activity namespace: molecular_function def: "Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate." [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN] subset: gosubset_prok synonym: "cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13] synonym: "cysteine-S-conjugate b-lyase activity" EXACT [] synonym: "glutamine transaminase K/cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13] synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" EXACT [EC:4.4.1.13] synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.13] xref: EC:4.4.1.13 xref: GO:0047804 xref: MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0007104 name: cytidylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate." [EC:4.6.1.6, MetaCyc:CYTIDYLATE-CYCLASE-RXN] synonym: "3',5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6] synonym: "3'5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6] synonym: "CTP diphosphate-lyase (cyclizing)" EXACT [EC:4.6.1.6] synonym: "CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)" EXACT [EC:4.6.1.6] synonym: "cytidyl cyclase activity" EXACT [EC:4.6.1.6] synonym: "cytidylyl cyclase activity" EXACT [EC:4.6.1.6] xref: EC:4.6.1.6 xref: GO:0047805 xref: MetaCyc:CYTIDYLATE-CYCLASE-RXN is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003413 ! phosphorus-oxygen lyase activity [Term] id: CCO:F0007105 name: cytochrome-c3 hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3." [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN] subset: gosubset_prok synonym: "cytochrome c3 reductase activity" EXACT [EC:1.12.2.1] synonym: "cytochrome hydrogenase activity" BROAD [EC:1.12.2.1] synonym: "H(2):ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1] synonym: "H2:ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1] synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" EXACT [EC:1.12.2.1] xref: EC:1.12.2.1 xref: GO:0047806 xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN is_a: CCO:F0003283 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor [Term] id: CCO:F0007106 name: cytokinin 7-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + N6-alkylaminopurine = UDP + N6-alkylaminopurine-7-beta-D-glucoside." [EC:2.4.1.118, MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "cytokinin 7-b-glucosyltransferase activity" EXACT [] synonym: "cytokinin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "UDP-glucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "UDP-glucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "UDPglucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "uridine diphosphoglucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] xref: EC:2.4.1.118 xref: GO:0047807 xref: MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007107 name: D(-)-tartrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S,S)-tartrate = oxaloacetate + H2O." [EC:4.2.1.81, MetaCyc:D(-)-TARTRATE-DEHYDRATASE-RXN] synonym: "(S,S)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.81] synonym: "(S,S)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.81] synonym: "D-tartrate dehydratase activity" EXACT [EC:4.2.1.81] xref: EC:4.2.1.81 xref: GO:0047808 xref: MetaCyc:D(-)-TARTRATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007108 name: D-2-hydroxy-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + acceptor = pyruvate + reduced acceptor." [EC:1.1.99.6, MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN] synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.6] synonym: "2-hydroxy acid dehydrogenase activity" EXACT [EC:1.1.99.6] xref: EC:1.1.99.6 xref: GO:0047809 xref: MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007109 name: D-alanine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate." [EC:2.6.1.21, MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN] subset: gosubset_prok synonym: "D-alanine aminotransferase activity" EXACT [] synonym: "D-alanine-D-glutamate transaminase activity" EXACT [EC:2.6.1.21] synonym: "D-alanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.21] synonym: "D-amino acid aminotransferase activity" BROAD [EC:2.6.1.21] synonym: "D-amino acid transaminase activity" BROAD [EC:2.6.1.21] synonym: "D-amino-acid transaminase activity" EXACT [EC:2.6.1.21] synonym: "D-aspartate aminotransferase activity" RELATED [EC:2.6.1.21] synonym: "D-aspartate transaminase activity" RELATED [EC:2.6.1.21] synonym: "D-aspartic aminotransferase activity" RELATED [EC:2.6.1.21] xref: EC:2.6.1.21 xref: GO:0047810 xref: MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007110 name: D-alanine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + D-alanine = NH3 + g-L-glutamyl-D-alanine." [EC:2.3.2.14, MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN] synonym: "D-alanine g-glutamyltransferase activity" EXACT [] synonym: "L-glutamine:D-alanine gamma-glutamyltransferase activity" EXACT [EC:2.3.2.14] xref: EC:2.3.2.14 xref: GO:0047811 xref: MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0007111 name: D-amino-acid N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid." [EC:2.3.1.36, MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:D-amino-acid N-acetyltransferase activity" EXACT [EC:2.3.1.36] synonym: "D-amino acid acetyltransferase activity" EXACT [EC:2.3.1.36] synonym: "D-amino acid-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.36] xref: EC:2.3.1.36 xref: GO:0047812 xref: MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0007112 name: D-arabinitol 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH." [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN] subset: gosubset_prok xref: EC:1.1.1.11 xref: GO:0047813 xref: MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007113 name: D-arabinokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-arabinose = ADP + D-arabinose 5-phosphate." [EC:2.7.1.54, MetaCyc:D-ARABINOKINASE-RXN] synonym: "ATP:D-arabinose 5-phosphotransferase activity" EXACT [EC:2.7.1.54] synonym: "D-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.54] xref: EC:2.7.1.54 xref: GO:0047814 xref: MetaCyc:D-ARABINOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007114 name: D-arabinonolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate." [EC:3.1.1.30, MetaCyc:D-ARABINONOLACTONASE-RXN] synonym: "D-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.30] xref: EC:3.1.1.30 xref: GO:0047815 xref: MetaCyc:D-ARABINONOLACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007115 name: D-arabinose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN] synonym: "arabinose(fucose)dehydrogenase activity" EXACT [EC:1.1.1.116] synonym: "D-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.116] synonym: "NAD-pentose-dehydrogenase activity" EXACT [EC:1.1.1.116] xref: EC:1.1.1.116 xref: GO:0047816 xref: MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007116 name: D-arginase activity namespace: molecular_function def: "Catalysis of the reaction: D-arginine + H2O = D-ornithine + urea." [EC:3.5.3.10, MetaCyc:D-ARGINASE-RXN] synonym: "D-arginine amidinohydrolase activity" EXACT [EC:3.5.3.10] xref: EC:3.5.3.10 xref: GO:0047817 xref: MetaCyc:D-ARGINASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0007117 name: D-fuconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O." [EC:4.2.1.67, MetaCyc:D-FUCONATE-HYDRATASE-RXN] synonym: "D-fuconate hydratase activity" EXACT [] synonym: "D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)" EXACT [EC:4.2.1.67] synonym: "D-fuconate hydro-lyase activity" EXACT [EC:4.2.1.67] xref: EC:4.2.1.67 xref: GO:0047818 xref: MetaCyc:D-FUCONATE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007118 name: D-glutamate(D-aspartate) oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.15, MetaCyc:D-GLUTAMATE(D-ASPARTATE)-OXIDASE-RXN] synonym: "D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.15] synonym: "D-glutamic-aspartic oxidase activity" EXACT [EC:1.4.3.15] synonym: "D-monoaminodicarboxylic acid oxidase activity" EXACT [EC:1.4.3.15] xref: EC:1.4.3.15 xref: GO:0047819 xref: MetaCyc:D-GLUTAMATE(D-ASPARTATE)-OXIDASE-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0007119 name: D-glutamate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O." [EC:4.2.1.48, MetaCyc:D-GLUTAMATE-CYCLASE-RXN] synonym: "D-glutamate hydro-lyase (cyclizing)" EXACT [EC:4.2.1.48] synonym: "D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)" EXACT [EC:4.2.1.48] xref: EC:4.2.1.48 xref: GO:0047820 xref: MetaCyc:D-GLUTAMATE-CYCLASE-RXN is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007120 name: D-glutamate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2; D-aspartate + H2O = oxaloacetate + NH3 + H2O2." [BRENDA:1.4.3.15, EC:1.4.3.7, MetaCyc:D-GLUTAMATE-OXIDASE-RXN] synonym: "D-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.7] synonym: "D-glutamic acid oxidase activity" EXACT [EC:1.4.3.7] synonym: "D-glutamic oxidase activity" EXACT [EC:1.4.3.7] xref: EC:1.4.3.7 xref: GO:0047821 xref: MetaCyc:D-GLUTAMATE-OXIDASE-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0007121 name: hypotaurine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hypotaurine + H2O + NAD+ = taurine + NADH." [EC:1.8.1.3, MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN] synonym: "hypotaurine:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.3] xref: EC:1.8.1.3 xref: GO:0047822 xref: MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007122 name: D-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide." [EC:2.3.2.1, MetaCyc:D-GLUTAMYLTRANSFERASE-RXN] synonym: "D-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1] synonym: "D-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1] synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" EXACT [EC:2.3.2.1] xref: EC:2.3.2.1 xref: GO:0047823 xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0007123 name: D-iditol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH." [EC:1.1.1.15, MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN] xref: EC:1.1.1.15 xref: GO:0047824 xref: MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: CCO:F0004651 ! hexitol dehydrogenase activity [Term] id: CCO:F0007124 name: D-lactate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-O-sulfolactate + H2O = (S)-lactate + SO4(2-) (sulfate)." [EC:3.1.6.17, MetaCyc:D-LACTATE-2-SULFATASE-RXN] synonym: "(S)-2-O-sulfolactate 2-sulfohydrolase activity" EXACT [EC:3.1.6.17] synonym: "D-lactate-2-sulphatase activity" EXACT [] xref: EC:3.1.6.17 xref: GO:0047825 xref: MetaCyc:D-LACTATE-2-SULFATASE-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0007125 name: D-lysine 5,6-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate." [EC:5.4.3.4, MetaCyc:D-LYSINE-5] synonym: "adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.4] synonym: "D-2,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.4] synonym: "D-alpha-lysine mutase activity" EXACT [EC:5.4.3.4] xref: EC:5.4.3.4 xref: GO:0047826 xref: MetaCyc:D-LYSINE-5 is_a: CCO:F0003430 ! intramolecular transferase activity, transferring amino groups [Term] id: CCO:F0007126 name: D-lysopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-lysine + NADP+ + H2O = L-lysine + pyruvate + NADPH." [EC:1.5.1.16, MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16] synonym: "D(+)-lysopine dehydrogenase activity" EXACT [EC:1.5.1.16] synonym: "D-lysopine synthase activity" EXACT [EC:1.5.1.16] synonym: "lysopine dehydrogenase activity" EXACT [EC:1.5.1.16] synonym: "N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16] xref: EC:1.5.1.16 xref: GO:0047827 xref: MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007127 name: D-lyxose ketol-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-lyxose = D-xylulose." [EC:5.3.1.15, MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN] synonym: "D-lyxose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.15] synonym: "D-lyxose isomerase activity" EXACT [EC:5.3.1.15] xref: EC:5.3.1.15 xref: GO:0047828 xref: MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0007128 name: D-nopaline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH." [EC:1.5.1.19, MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19] synonym: "D-nopaline synthase activity" EXACT [EC:1.5.1.19] synonym: "N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19] synonym: "nopaline dehydrogenase activity" EXACT [EC:1.5.1.19] synonym: "nopaline synthase activity" EXACT [EC:1.5.1.19] synonym: "NOS activity" EXACT [EC:1.5.1.19] xref: EC:1.5.1.19 xref: GO:0047829 xref: MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007129 name: D-octopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH." [EC:1.5.1.11, MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11] synonym: "D-octopine synthase activity" EXACT [EC:1.5.1.11] synonym: "N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11] synonym: "octopine dehydrogenase activity" EXACT [EC:1.5.1.11] synonym: "octopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.11] synonym: "ODH activity" EXACT [EC:1.5.1.11] xref: EC:1.5.1.11 xref: GO:0047830 xref: MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007130 name: D-ornithine 4,5-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate." [EC:5.4.3.5, MetaCyc:ORNMUTST-RXN] synonym: "D-alpha-ornithine 5,4-aminomutase activity" EXACT [EC:5.4.3.5] synonym: "D-ornithine aminomutase activity" EXACT [EC:5.4.3.5] xref: EC:5.4.3.5 xref: GO:0047831 xref: MetaCyc:ORNMUTST-RXN is_a: CCO:F0003430 ! intramolecular transferase activity, transferring amino groups [Term] id: CCO:F0007131 name: D-pinitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP+ = 5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH." [EC:1.1.1.142, MetaCyc:D-PINITOL-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142] synonym: "5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142] xref: EC:1.1.1.142 xref: GO:0047832 xref: MetaCyc:D-PINITOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007132 name: D-sorbitol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor." [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN] synonym: "D-sorbitol dehydrogenase activity" EXACT [] synonym: "D-sorbitol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.21] synonym: "D-sorbitol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.21] xref: EC:1.1.99.21 xref: GO:0047833 xref: MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007133 name: D-threo-aldose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH." [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "(2S,3R)-aldose dehydrogenase activity" EXACT [EC:1.1.1.122] synonym: "D-threo-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.122] synonym: "dehydrogenase, L-fucose" EXACT [EC:1.1.1.122] synonym: "L-fucose (D-arabinose) dehydrogenase activity" EXACT [EC:1.1.1.122] synonym: "L-fucose dehydrogenase activity" EXACT [EC:1.1.1.122] xref: EC:1.1.1.122 xref: GO:0047834 xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007134 name: D-tryptophan N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + D-tryptophan = CoA + N-acetyl-D-tryptophan." [EC:2.3.1.34, MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.34] synonym: "acetyl-CoA:D-tryptophan N-acetyltransferase activity" EXACT [EC:2.3.1.34] synonym: "D-tryptophan acetyltransferase activity" EXACT [EC:2.3.1.34] xref: EC:2.3.1.34 xref: GO:0047835 xref: MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0007135 name: D-tryptophan N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + D-tryptophan = CoA + N2-malonyl-D-tryptophan." [EC:2.3.1.112, MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN] synonym: "malonyl-CoA:D-tryptophan N-malonyltransferase activity" EXACT [EC:2.3.1.112] xref: EC:2.3.1.112 xref: GO:0047836 xref: MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN is_a: CCO:F0008003 ! N-malonyltransferase activity [Term] id: CCO:F0007136 name: D-xylose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH." [EC:1.1.1.179, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-(NADP+)-RXN] subset: gosubset_prok synonym: "D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.179] synonym: "D-xylose-NADP dehydrogenase activity" EXACT [EC:1.1.1.179] synonym: "D-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.179] synonym: "D-xylose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.179] xref: EC:1.1.1.179 xref: GO:0047837 xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007137 name: D-xylose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH." [EC:1.1.1.175, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN] synonym: "(NAD)-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] synonym: "D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] synonym: "D-xylose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.175] synonym: "NAD-D-xylose" RELATED [EC:1.1.1.175] synonym: "NAD-D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] synonym: "NAD-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] xref: EC:1.1.1.175 xref: GO:0047838 xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007138 name: dATP(dGTP)-DNA purinetransferase activity namespace: molecular_function def: "Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA." [EC:2.6.99.1, MetaCyc:DATP(DGTP)--DNA-PURINE-TRANSFERASE-RXN] synonym: "dATP(dGTP)--DNA purine transferase activity" EXACT [] synonym: "dATP(dGTP):depurinated-DNA purine transferase activity" EXACT [EC:2.6.99.1] xref: EC:2.6.99.1 xref: GO:0047839 xref: MetaCyc:DATP(DGTP)--DNA-PURINE-TRANSFERASE-RXN is_a: CCO:F0003342 ! transferase activity, transferring nitrogenous groups [Term] id: CCO:F0007139 name: dCTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate." [EC:3.6.1.12, MetaCyc:DCTP-PYROPHOSPHATASE-RXN] synonym: "dCTP nucleotidohydrolase activity" EXACT [EC:3.6.1.12] synonym: "dCTP pyrophosphatase activity" EXACT [] synonym: "dCTPase activity" EXACT [EC:3.6.1.12] synonym: "deoxy-CTPase activity" EXACT [EC:3.6.1.12] synonym: "deoxycytidine triphosphatase activity" EXACT [EC:3.6.1.12] synonym: "deoxycytidine-triphosphatase activity" EXACT [EC:3.6.1.12] xref: EC:3.6.1.12 xref: GO:0047840 xref: MetaCyc:DCTP-PYROPHOSPHATASE-RXN is_a: CCO:F0006737 ! nucleoside-triphosphate diphosphatase activity [Term] id: CCO:F0007140 name: dehydrogluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-dehydro-D-gluconate = ADP + 6-phospho-2-dehydro-D-gluconate." [EC:2.7.1.13, MetaCyc:DEHYDOGLUCONOKINASE-RXN] synonym: "2-ketogluconate kinase activity" EXACT [EC:2.7.1.13] synonym: "2-ketogluconokinase activity" EXACT [EC:2.7.1.13] synonym: "ATP:2-dehydro-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.13] synonym: "dehydogluconokinase activity" EXACT [] synonym: "ketogluconokinase (phosphorylating)" EXACT [EC:2.7.1.13] synonym: "ketogluconokinase activity" EXACT [EC:2.7.1.13] xref: EC:2.7.1.13 xref: GO:0047841 xref: MetaCyc:DEHYDOGLUCONOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007141 name: dehydro-L-gulonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydro-L-gulonate = L-xylulose + CO2." [EC:4.1.1.34, MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN] synonym: "3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)" EXACT [EC:4.1.1.34] synonym: "3-dehydro-L-gulonate carboxy-lyase activity" EXACT [EC:4.1.1.34] synonym: "3-keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34] synonym: "keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34] xref: EC:4.1.1.34 xref: GO:0047842 xref: MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007142 name: dehydrogluconate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-D-gluconate + acceptor = 2,5-didehydro-D-gluconate + reduced acceptor." [EC:1.1.99.4, MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN] synonym: "2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.4] synonym: "2-keto-D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.4] synonym: "2-oxogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] synonym: "alpha-ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] synonym: "ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] xref: EC:1.1.99.4 xref: GO:0047843 xref: MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007143 name: deoxycytidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3." [EC:3.5.4.14, MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN] subset: gosubset_prok synonym: "deoxycytidine aminohydrolase activity" EXACT [EC:3.5.4.14] xref: EC:3.5.4.14 xref: GO:0047844 xref: MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0007144 name: deoxylimonate A-ring-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: deoxylimonate + H2O = deoxylimononic acid D-ring-lactone." [EC:3.1.1.46, MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN] synonym: "deoxylimonate A-ring-lactonohydrolase activity" EXACT [EC:3.1.1.46] xref: EC:3.1.1.46 xref: GO:0047845 xref: MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007145 name: deoxynucleotide 3'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate." [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3] synonym: "3'-deoxynucleotidase activity" EXACT [EC:3.1.3.34] synonym: "3'-deoxyribonucleotidase activity" EXACT [EC:3.1.3.34] synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.34] xref: EC:3.1.3.34 xref: GO:0047846 xref: MetaCyc:DEOXYNUCLEOTIDE-3 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007146 name: deoxyuridine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate." [EC:2.4.2.23, MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN] synonym: "2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] synonym: "deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] synonym: "deoxyuridine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] xref: EC:2.4.2.23 xref: GO:0047847 xref: MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0007147 name: dephospho-[reductase kinase] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]." [EC:2.7.11.3, MetaCyc:DEPHOSPHO-[REDUCTASE-KINASE\]-KINASE-RXN] synonym: "AMP-activated kinase activity" EXACT [EC:2.7.11.3] synonym: "AMP-activated protein kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity" EXACT [EC:2.7.11.3] synonym: "dephospho-reductase kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity" EXACT [EC:2.7.11.3] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "reductase kinase activity" BROAD [EC:2.7.11.3] synonym: "reductase kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "STK30" RELATED [EC:2.7.11.3] xref: EC:2.7.11.3 xref: GO:0047848 xref: MetaCyc:DEPHOSPHO-[REDUCTASE-KINASE\]-KINASE-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0007148 name: dextransucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)." [EC:2.4.1.5, MetaCyc:DEXTRANSUCRASE-RXN] subset: gosubset_prok synonym: "CEP" RELATED [EC:2.4.1.5] synonym: "SGE" RELATED [EC:2.4.1.5] synonym: "sucrose 6-glucosyltransferase activity" EXACT [EC:2.4.1.5] synonym: "sucrose-1,6-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.5] synonym: "sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.5] xref: EC:2.4.1.5 xref: GO:0047849 xref: MetaCyc:DEXTRANSUCRASE-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0007149 name: diaminopimelate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH." [EC:1.4.1.16, MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.16] synonym: "meso-alpha,epsilon-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16] synonym: "meso-diaminopimelate D-dehydrogenase activity" EXACT [EC:1.4.1.16] synonym: "meso-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16] xref: EC:1.4.1.16 xref: GO:0047850 xref: MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007150 name: dicarboxylate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an omega-dicarboxylic acid = AMP + diphosphate + an omega-carboxyacyl-CoA." [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN] synonym: "carboxylyl-CoA synthetase activity" EXACT [EC:6.2.1.23] synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.23] xref: EC:6.2.1.23 xref: GO:0047851 xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007151 name: diferric-transferrin reductase activity namespace: molecular_function def: "Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH." [EC:1.16.1.2, MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN] synonym: "diferric transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "NADH diferric transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.2] xref: EC:1.16.1.2 xref: GO:0047852 xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN is_a: CCO:F0003305 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: CCO:F0007152 name: difructose-anhydride synthase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose." [EC:3.2.1.134, MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN] synonym: "bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity" EXACT [EC:3.2.1.134] synonym: "inulobiose hydrolase activity" EXACT [EC:3.2.1.134] xref: EC:3.2.1.134 xref: GO:0047853 xref: MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007153 name: diguanidinobutanase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-diguanidinobutane + H2O = agmatine + urea." [EC:3.5.3.20, MetaCyc:DIGUANIDINOBUTANASE-RXN] synonym: "1,4-diguanidinobutane amidinohydrolase activity" EXACT [EC:3.5.3.20] xref: EC:3.5.3.20 xref: GO:0047854 xref: MetaCyc:DIGUANIDINOBUTANASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0007154 name: dihydrobunolol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ = (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH." [EC:1.1.1.160, MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN] synonym: "(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.160] synonym: "bunolol reductase activity" EXACT [EC:1.1.1.160] xref: EC:1.1.1.160 xref: GO:0047855 xref: MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007155 name: dihydrocoumarin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrocoumarin + H2O = melilotate." [EC:3.1.1.35, MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN] subset: gosubset_prok synonym: "dihydrocoumarin lactonohydrolase activity" EXACT [EC:3.1.1.35] synonym: "dihydrocoumarin lipase activity" EXACT [] xref: EC:3.1.1.35 xref: GO:0047856 xref: MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007156 name: dihydrouracil oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + O2 = uracil + H2O2." [EC:1.3.3.7, MetaCyc:DIHYDROURACIL-OXIDASE-RXN] synonym: "5,6-dihydrouracil:oxygen oxidoreductase activity" EXACT [EC:1.3.3.7] xref: EC:1.3.3.7 xref: GO:0047857 xref: MetaCyc:DIHYDROURACIL-OXIDASE-RXN is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0007157 name: dihydroxyfumarate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroxyfumarate = tartronate semialdehyde + CO2." [EC:4.1.1.54, MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN] synonym: "dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.54] synonym: "dihydroxyfumarate carboxy-lyase activity" EXACT [EC:4.1.1.54] xref: EC:4.1.1.54 xref: GO:0047858 xref: MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007159 name: diiodophenylpyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.96, MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN] synonym: "2-oxo acid reductase activity" EXACT [EC:1.1.1.96] synonym: "3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.96] synonym: "aromatic alpha-keto acid" RELATED [EC:1.1.1.96] synonym: "KAR" RELATED [EC:1.1.1.96] xref: EC:1.1.1.96 xref: GO:0047860 xref: MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007160 name: diiodotyrosine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.24, MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN] synonym: "3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.24] synonym: "diiodotyrosine aminotransferase activity" EXACT [] synonym: "halogenated tyrosine aminotransferase activity" EXACT [EC:2.6.1.24] synonym: "halogenated tyrosine transaminase activity" EXACT [EC:2.6.1.24] xref: EC:2.6.1.24 xref: GO:0047861 xref: MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007161 name: diisopropyl-fluorophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride." [EC:3.1.8.2, MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN] synonym: "DFPase activity" EXACT [EC:3.1.8.2] synonym: "dialkylfluorophosphatase activity" EXACT [EC:3.1.8.2] synonym: "diisopropyl phosphorofluoridate hydrolase activity" EXACT [EC:3.1.8.2] synonym: "diisopropyl-fluorophosphate fluorohydrolase activity" EXACT [EC:3.1.8.2] synonym: "diisopropylfluorophosphonate dehalogenase activity" EXACT [EC:3.1.8.2] synonym: "diisopropylphosphofluoridase activity" EXACT [EC:3.1.8.2] synonym: "isopropylphosphorofluoridase activity" EXACT [EC:3.1.8.2] synonym: "OPA anhydrase activity" EXACT [EC:3.1.8.2] synonym: "OPAA activity" EXACT [EC:3.1.8.2] synonym: "organophosphate acid anhydrase activity" EXACT [EC:3.1.8.2] synonym: "organophosphorus acid anhydrolase activity" EXACT [EC:3.1.8.2] synonym: "somanase activity" EXACT [EC:3.1.8.2] synonym: "tabunase activity" EXACT [EC:3.1.8.2] xref: EC:3.1.8.2 xref: GO:0047862 xref: MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN is_a: CCO:F0003365 ! phosphoric triester hydrolase activity [Term] id: CCO:F0007162 name: dimethylallylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate." [EC:2.5.1.28, MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN] synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity" EXACT [EC:2.5.1.28] synonym: "neryl-diphosphate synthase activity" EXACT [EC:2.5.1.28] xref: EC:2.5.1.28 xref: GO:0047863 xref: MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0007163 name: dimethylaniline-N-oxide aldolase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde." [EC:4.1.2.24, MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN] subset: gosubset_prok synonym: "microsomal N-oxide dealkylase activity" EXACT [EC:4.1.2.24] synonym: "microsomal oxidase II" RELATED [EC:4.1.2.24] synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)" EXACT [EC:4.1.2.24] synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.24] xref: EC:4.1.2.24 xref: GO:0047864 xref: MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007164 name: dimethylglycine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde + reduced acceptor." [EC:1.5.99.2, MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "N,N-dimethylglycine oxidase activity" EXACT [EC:1.5.99.2] synonym: "N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.2] synonym: "N,N-dimethylglycine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.2] xref: EC:1.5.99.2 xref: GO:0047865 xref: MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0007165 name: dimethylglycine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = sarcosine + formaldehyde + H2O2." [EC:1.5.3.10, MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN] synonym: "N,N-dimethylglycine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.10] xref: EC:1.5.3.10 xref: GO:0047866 xref: MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0007166 name: dimethylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH." [EC:1.1.1.84, MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN] synonym: "(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.84] synonym: "beta,beta-dimethylmalate dehydrogenase activity" EXACT [EC:1.1.1.84] xref: EC:1.1.1.84 xref: GO:0047867 xref: MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007167 name: dimethylmaleate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O." [EC:4.2.1.85, MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN] synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)" EXACT [EC:4.2.1.85] synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase activity" EXACT [EC:4.2.1.85] xref: EC:4.2.1.85 xref: GO:0047868 xref: MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007168 name: dimethylpropiothetin dethiomethylase activity namespace: molecular_function def: "Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = dimethyl sulfide + acrylate." [EC:4.4.1.3, MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN] synonym: "desulfhydrase activity" EXACT [EC:4.4.1.3] synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)" EXACT [EC:4.4.1.3] synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity" EXACT [EC:4.4.1.3] xref: EC:4.4.1.3 xref: GO:0047869 xref: MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0007169 name: discadenine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + N6-(D2-isopentenyl)-adenine = 5'-methylthioadenosine + discadenine." [EC:2.5.1.24, MetaCyc:DISCADENINE-SYNTHASE-RXN] synonym: "discadenine synthetase activity" EXACT [EC:2.5.1.24] synonym: "S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity" EXACT [EC:2.5.1.24] synonym: "S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas" RELATED [EC:2.5.1.24] xref: EC:2.5.1.24 xref: GO:0047870 xref: MetaCyc:DISCADENINE-SYNTHASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007170 name: disulfoglucosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: N,6-O-disulfo-D-glucosamine + H2O = N-sulfo-D-glucosamine + SO4(2-) (sulfate)." [EC:3.1.6.11, MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN] synonym: "6,N-disulfoglucosamine 6-O-sulfohydrolase activity" EXACT [EC:3.1.6.11] synonym: "disulphoglucosamine-6-sulphatase activity" EXACT [] synonym: "N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity" EXACT [EC:3.1.6.11] synonym: "N-sulfoglucosamine-6-sulfatase activity" EXACT [EC:3.1.6.11] xref: EC:3.1.6.11 xref: GO:0047871 xref: MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0007171 name: dolichol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate." [EC:2.3.1.123, MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:dolichol acyltransferase activity" EXACT [EC:2.3.1.123] synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" EXACT [EC:2.3.1.123] xref: EC:2.3.1.123 xref: GO:0047872 xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0007172 name: dolichyl-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate." [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN] synonym: "Dol-P phosphatase activity" EXACT [EC:3.1.3.51] synonym: "Dol-P-P phosphohydrolase activity" EXACT [] synonym: "dolichol monophosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichol phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichol phosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichyl monophosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichyl phosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichyl pyrophosphate phosphatase activity" EXACT [] synonym: "dolichyl-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.51] synonym: "polyisoprenyl phosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "polyprenylphosphate phosphatase activity" EXACT [EC:3.1.3.51] xref: EC:3.1.3.51 xref: GO:0047873 xref: MetaCyc:DOLICHYL-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007173 name: dolichyldiphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN] synonym: "dolichol diphosphatase activity" EXACT [EC:3.6.1.43] synonym: "dolichyl diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43] synonym: "dolichyl pyrophosphatase activity" EXACT [EC:3.6.1.43] synonym: "dolichyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43] xref: EC:3.6.1.43 xref: GO:0047874 xref: MetaCyc:DOLICHYLDIPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0007174 name: ecdysone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ecdysone + O2 = 3-dehydroecdysone + H2O2." [EC:1.1.3.16, MetaCyc:ECDYSONE-OXIDASE-RXN] synonym: "beta-ecdysone oxidase activity" EXACT [EC:1.1.3.16] synonym: "ecdysone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.16] xref: EC:1.1.3.16 xref: GO:0047875 xref: MetaCyc:ECDYSONE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007175 name: endoglycosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose." [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN] subset: gosubset_prok synonym: "EGCase activity" EXACT [EC:3.2.1.123] synonym: "endo-glucosylceramidase activity" EXACT [EC:3.2.1.123] synonym: "endoglycoceramidase activity" EXACT [EC:3.2.1.123] synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.123] synonym: "oligoglycosylglucosylceramide glycohydrolase activity" EXACT [EC:3.2.1.123] xref: EC:3.2.1.123 xref: GO:0047876 xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007176 name: ephedrine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + NADH." [EC:1.5.1.18, MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN] synonym: "(-)-ephedrine:NAD+ 2-oxidoreductase activity" EXACT [EC:1.5.1.18] xref: EC:1.5.1.18 xref: GO:0047877 xref: MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007177 name: erythritol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + erythritol = ADP + D-erythritol 4-phosphate." [EC:2.7.1.27, MetaCyc:ERYTHRITOL-KINASE-RXN] subset: gosubset_prok synonym: "ATP:erythritol 4-phosphotransferase activity" EXACT [EC:2.7.1.27] synonym: "erythritol kinase (phosphorylating)" EXACT [EC:2.7.1.27] xref: EC:2.7.1.27 xref: GO:0047878 xref: MetaCyc:ERYTHRITOL-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007178 name: erythronolide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B." [EC:2.3.1.94, MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN] subset: gosubset_prok synonym: "erythronolide condensing enzyme activity" EXACT [EC:2.3.1.94] synonym: "malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.94] xref: EC:2.3.1.94 xref: GO:0047879 xref: MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007179 name: erythrulose reductase activity namespace: molecular_function def: "Catalysis of the reaction: erythritol + NADP+ = D-erythrulose + NADPH." [EC:1.1.1.162, MetaCyc:ERYTHRULOSE-REDUCTASE-RXN] synonym: "D-erythrulose reductase activity" EXACT [EC:1.1.1.162] synonym: "erythritol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.162] xref: EC:1.1.1.162 xref: GO:0047880 xref: MetaCyc:ERYTHRULOSE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007180 name: estradiol 17-alpha-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+." [EC:1.1.1.148, MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN] synonym: "17alpha-estradiol dehydrogenase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.148] synonym: "estradiol 17a-dehydrogenase activity" EXACT [] synonym: "estradiol 17alpha-dehydrogenase activity" EXACT [EC:1.1.1.148] synonym: "estradiol 17alpha-oxidoreductase activity" EXACT [EC:1.1.1.148] xref: EC:1.1.1.148 xref: GO:0047881 xref: MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007181 name: estradiol 6-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-beta + donor-H2 + O2 = 6-beta-hydroxyestradiol-17-beta + acceptor + H2O." [EC:1.14.99.11, MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN] synonym: "estradiol 6-beta-hydroxylase activity" EXACT [EC:1.14.99.11] synonym: "estradiol 6b-hydroxylase activity" EXACT [] synonym: "estradiol 6b-monooxygenase activity" EXACT [] synonym: "estradiol 6beta-hydroxylase activity" EXACT [EC:1.14.99.11] synonym: "estradiol 6beta-monooxygenase activity" EXACT [EC:1.14.99.11] synonym: "estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)" EXACT [EC:1.14.99.11] xref: EC:1.14.99.11 xref: GO:0047882 xref: MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007182 name: ethanolamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2." [EC:1.4.3.8, MetaCyc:ETHANOLAMINE-OXIDASE-RXN] synonym: "ethanolamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.8] xref: EC:1.4.3.8 xref: GO:0047883 xref: MetaCyc:ETHANOLAMINE-OXIDASE-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0007183 name: FAD diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: FAD + H2O = AMP + FMN." [EC:3.6.1.18, MetaCyc:FAD-PYROPHOSPHATASE-RXN] synonym: "FAD nucleotidohydrolase activity" EXACT [EC:3.6.1.18] synonym: "FAD pyrophosphatase activity" EXACT [] synonym: "flavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] synonym: "flavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] synonym: "riboflavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] synonym: "riboflavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] xref: EC:3.6.1.18 xref: GO:0047884 xref: MetaCyc:FAD-PYROPHOSPHATASE-RXN is_a: CCO:F0000937 ! nucleotide diphosphatase activity [Term] id: CCO:F0007184 name: farnesol 2-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol." [EC:5.2.1.9, MetaCyc:FARNESOL-2-ISOMERASE-RXN] subset: gosubset_prok synonym: "2-trans,6-trans-farnesol 2-cis-trans-isomerase activity" EXACT [EC:5.2.1.9] synonym: "farnesol isomerase activity" EXACT [EC:5.2.1.9] xref: EC:5.2.1.9 xref: GO:0047885 xref: MetaCyc:FARNESOL-2-ISOMERASE-RXN is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0007185 name: farnesol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP+ = 2-trans,6-trans-farnesal + NADPH." [EC:1.1.1.216, MetaCyc:FARNESOL-DEHYDROGENASE-RXN] synonym: "2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.216] synonym: "farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.216] synonym: "NADP-farnesol dehydrogenase activity" EXACT [EC:1.1.1.216] xref: EC:1.1.1.216 xref: GO:0047886 xref: MetaCyc:FARNESOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007186 name: farnesyl diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + farnesyl diphosphate = ADP + farnesyl triphosphate." [EC:2.7.4.18, MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN] synonym: "ATP:farnesyl-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.18] synonym: "farnesyl pyrophosphate kinase activity" EXACT [EC:2.7.4.18] synonym: "farnesyl-diphosphate kinase activity" EXACT [] xref: EC:2.7.4.18 xref: GO:0047887 xref: MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0007187 name: fatty-acid peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: palmitate + 2 H2O2 = pentadecanal + CO2 + 3 H2O." [EC:1.11.1.3, MetaCyc:FATTY-ACID-PEROXIDASE-RXN] synonym: "fatty acid peroxidase activity" EXACT [] synonym: "hexadecanoate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.3] synonym: "long chain fatty acid peroxidase activity" EXACT [EC:1.11.1.3] xref: EC:1.11.1.3 xref: GO:0047888 xref: MetaCyc:FATTY-ACID-PEROXIDASE-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0007188 name: ferredoxin-nitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: NO2- (nitrite) + H2O + 2 oxidized ferredoxin = NO3- (nitrate) + 2 reduced ferredoxin." [EC:1.7.7.2, MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN] synonym: "assimilatory ferredoxin-nitrate reductase activity" EXACT [EC:1.7.7.2] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.7.2] synonym: "nitrate (ferredoxin) reductase activity" EXACT [EC:1.7.7.2] synonym: "nitrite:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.2] xref: EC:1.7.7.2 xref: GO:0047889 xref: MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN is_a: CCO:F0003259 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor [Term] id: CCO:F0007189 name: flavanone 4-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH." [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN] synonym: "(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.234] synonym: "flavonone 4-reductase activity" EXACT [] xref: EC:1.1.1.234 xref: GO:0047890 xref: MetaCyc:FLAVANONE-4-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007190 name: flavone 7-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone." [EC:2.4.1.81, MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "flavone 7-O-b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDP-glucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDPglucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDPglucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "uridine diphosphoglucose-luteolin glucosyltransferase activity" EXACT [EC:2.4.1.81] xref: EC:2.4.1.81 xref: GO:0047891 xref: MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007191 name: flavone apiosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone." [EC:2.4.2.25, MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN] synonym: "UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity" EXACT [EC:2.4.2.25] synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25] synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25] xref: EC:2.4.2.25 xref: GO:0047892 xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0007192 name: flavonol 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside." [EC:2.4.1.91, MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN] synonym: "GTI" RELATED [EC:2.4.1.91] synonym: "UDP-glucose flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDP-glucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDP-glucose:flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDPG:flavonoid-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDPglucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] xref: EC:2.4.1.91 xref: GO:0047893 xref: MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007193 name: flavonol 3-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + quercetin = adenosine 3',5'-bisphosphate + quercetin 3-sulfate." [EC:2.8.2.25, MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT [EC:2.8.2.25] synonym: "flavonol 3-sulphotransferase activity" EXACT [] xref: EC:2.8.2.25 xref: GO:0047894 xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007194 name: formaldehyde dismutase activity namespace: molecular_function def: "Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate." [EC:1.2.99.4, MetaCyc:FORMALDEHYDE-DISMUTASE-RXN] synonym: "aldehyde dismutase activity" EXACT [EC:1.2.99.4] synonym: "cannizzanase activity" EXACT [EC:1.2.99.4] synonym: "formaldehyde:formaldehyde oxidoreductase activity" EXACT [EC:1.2.99.4] xref: EC:1.2.99.4 xref: GO:0047895 xref: MetaCyc:FORMALDEHYDE-DISMUTASE-RXN is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0007195 name: formaldehyde transketolase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone." [EC:2.2.1.3, MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN] synonym: "D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity" EXACT [EC:2.2.1.3] synonym: "DHAS activity" EXACT [EC:2.2.1.3] synonym: "dihydroxyacetone synthase activity" EXACT [EC:2.2.1.3] synonym: "glycerone synthase activity" EXACT [EC:2.2.1.3] xref: EC:2.2.1.3 xref: GO:0047896 xref: MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN is_a: CCO:F0003320 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: CCO:F0007196 name: formate-dihydrofolate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate." [EC:6.3.4.17, MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN] synonym: "dihydrofolate formyltransferase activity" EXACT [EC:6.3.4.17] synonym: "formate:dihydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.17] synonym: "formyl dihydrofolate synthase activity" EXACT [EC:6.3.4.17] xref: EC:6.3.4.17 xref: GO:0047897 xref: MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0007197 name: formate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1." [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-(CYTOCHROME)-RXN] synonym: "formate:cytochrome b1 oxidoreductase activity" EXACT [EC:1.2.2.1] synonym: "formate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.1] xref: EC:1.2.2.1 xref: GO:0047898 xref: MetaCyc:FORMATE-DEHYDROGENASE-(CYTOCHROME)-RXN is_a: CCO:F0003224 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: CCO:F0007198 name: formate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: formate + NADP+ = CO2 + NADPH." [EC:1.2.1.43, MetaCyc:FORMATE-DEHYDROGENASE-(NADP+)-RXN] subset: gosubset_prok synonym: "formate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.43] synonym: "NADP-dependent formate dehydrogenase activity" EXACT [EC:1.2.1.43] xref: EC:1.2.1.43 xref: GO:0047899 xref: MetaCyc:FORMATE-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007199 name: formate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + formate = ADP + formyl phosphate." [EC:2.7.2.6, MetaCyc:FORMATE-KINASE-RXN] synonym: "ATP:formate phosphotransferase activity" EXACT [EC:2.7.2.6] xref: EC:2.7.2.6 xref: GO:0047900 xref: MetaCyc:FORMATE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0007200 name: formyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: formyl-CoA + H2O = CoA + formate." [EC:3.1.2.10, MetaCyc:FORMYL-COA-HYDROLASE-RXN] synonym: "formyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.10] xref: EC:3.1.2.10 xref: GO:0047901 xref: MetaCyc:FORMYL-COA-HYDROLASE-RXN is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0007201 name: formylaspartate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate." [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN] synonym: "formylaspartic formylase (formylase I, formylase II)" EXACT [EC:3.5.1.8] synonym: "N-formyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.8] xref: EC:3.5.1.8 xref: GO:0047902 xref: MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007202 name: fructose 5-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-(NADP+)-RXN] subset: gosubset_prok synonym: "5-keto-D-fructose reductase (NADP+)" EXACT [EC:1.1.1.124] synonym: "5-ketofructose reductase (NADP(+)) activity" EXACT [EC:1.1.1.124] synonym: "5-ketofructose reductase (NADP)" EXACT [EC:1.1.1.124] synonym: "5-ketofructose reductase (NADP+) activity" EXACT [EC:1.1.1.124] synonym: "D-(-)fructose:(NADP+) 5-oxidoreductase activity" EXACT [EC:1.1.1.124] synonym: "D-fructose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.124] synonym: "fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.124] xref: EC:1.1.1.124 xref: GO:0047903 xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007203 name: fructose 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose + acceptor = 5-dehydro-D-fructose + reduced acceptor." [EC:1.1.99.11, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN] synonym: "D-fructose dehydrogenase activity" EXACT [EC:1.1.99.11] synonym: "D-fructose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.11] synonym: "D-fructose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.11] synonym: "fructose 5-dehydrogenase (acceptor)" EXACT [EC:1.1.99.11] xref: EC:1.1.99.11 xref: GO:0047904 xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007204 name: fructose-6-phosphate phosphoketolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O." [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN] subset: gosubset_prok synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.22] synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.22] xref: EC:4.1.2.22 xref: GO:0047905 xref: MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007205 name: fucosterol-epoxide lyase activity namespace: molecular_function def: "Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = desmosterol + acetaldehyde." [EC:4.1.2.33, MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN] synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)" EXACT [EC:4.1.2.33] synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity" EXACT [EC:4.1.2.33] xref: EC:4.1.2.33 xref: GO:0047906 xref: MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007206 name: furylfuramide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide." [EC:5.2.1.6, MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN] synonym: "2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity" EXACT [EC:5.2.1.6] xref: EC:5.2.1.6 xref: GO:0047907 xref: MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0007207 name: fusarinine-C ornithinesterase activity namespace: molecular_function def: "Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol." [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN] synonym: "5-N-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48] synonym: "N5-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48] synonym: "ornithine esterase activity" EXACT [EC:3.1.1.48] xref: EC:3.1.1.48 xref: GO:0047908 xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007208 name: galactolipid O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol." [EC:2.3.1.134, MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN] synonym: "galactolipid:galactolipid acyltransferase activity" EXACT [EC:2.3.1.134] synonym: "mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.134] xref: EC:2.3.1.134 xref: GO:0047909 xref: MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0007209 name: galactose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH." [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-(NADP+)-RXN] synonym: "D-galactose dehydrogenase (NADP+)" EXACT [EC:1.1.1.120] synonym: "D-galactose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.120] xref: EC:1.1.1.120 xref: GO:0047910 xref: MetaCyc:GALACTOSE-1-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007210 name: galacturan 1,4-alpha-galacturonidase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-galacturonide(n) + H2O = 1,4-alpha-D-galacturonide(n-1) + D-galacturonate." [EC:3.2.1.67, MetaCyc:GALACTURAN-1] synonym: "exo-D-galacturonanase activity" EXACT [EC:3.2.1.67] synonym: "exo-D-galacturonase activity" EXACT [] synonym: "exo-polygalacturonase activity" EXACT [] synonym: "exopoly-D-galacturonase activity" EXACT [] synonym: "exopolygalacturonase activity" EXACT [EC:3.2.1.67] synonym: "galacturan 1,4-a-galacturonidase activity" EXACT [] synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" EXACT [EC:3.2.1.67] synonym: "poly(galacturonate) hydrolase activity" EXACT [EC:3.2.1.67] xref: EC:3.2.1.67 xref: GO:0047911 xref: MetaCyc:GALACTURAN-1 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007211 name: galacturonokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-galacturonate = ADP + 1-phospho-alpha-D-galacturonate." [EC:2.7.1.44, MetaCyc:GALACTURONOKINASE-RXN] synonym: "ATP:D-galacturonate 1-phosphotransferase activity" EXACT [EC:2.7.1.44] synonym: "galacturonokinase (phosphorylating) D-galacturonic acid kinase activity" EXACT [EC:2.7.1.44] xref: EC:2.7.1.44 xref: GO:0047912 xref: MetaCyc:GALACTURONOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007212 name: gallate 1-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + gallate = UDP + 1-galloyl-beta-D-glucose." [EC:2.4.1.136, MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "gallate 1-b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDP-glucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose:gallate glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose:vanillate 1-O-glucosyltransferase activity" EXACT [EC:2.4.1.136] xref: EC:2.4.1.136 xref: GO:0047913 xref: MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007213 name: gamma-glutamylhistamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown." [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN] synonym: "g-glutamylhistamine synthase activity" EXACT [] synonym: "gamma-GHA synthetase activity" EXACT [EC:6.3.2.18] synonym: "gamma-glutaminylhistamine synthetase activity" EXACT [EC:6.3.2.18] synonym: "L-glutamate:histamine ligase activity" EXACT [EC:6.3.2.18] xref: EC:6.3.2.18 xref: GO:0047914 xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0007214 name: ganglioside galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN] synonym: "GM1-synthase activity" EXACT [EC:2.4.1.62] synonym: "UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose-GM2 ganglioside galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDPgalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "uridine diphosphate D-galactose:glycolipid galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "uridine diphosphogalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "uridine diphosphogalactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62] xref: EC:2.4.1.62 xref: GO:0047915 xref: MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0007215 name: GDP-6-deoxy-D-talose 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+." [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN] synonym: "GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.135] synonym: "guanosine diphospho-6-deoxy-D-talose dehydrogenase activity" EXACT [EC:1.1.1.135] xref: EC:1.1.1.135 xref: GO:0047916 xref: MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007216 name: GDP-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-glucose + H2O = D-glucose + GDP." [EC:3.2.1.42, MetaCyc:GDP-GLUCOSIDASE-RXN] synonym: "GDP-glucose glucohydrolase activity" EXACT [EC:3.2.1.42] synonym: "GDPglucose glucohydrolase activity" EXACT [EC:3.2.1.42] synonym: "GDPglucosidase activity" EXACT [EC:3.2.1.42] synonym: "guanosine diphosphate D-glucose glucohydrolase activity" EXACT [EC:3.2.1.42] synonym: "guanosine diphosphoglucosidase activity" EXACT [EC:3.2.1.42] xref: EC:3.2.1.42 xref: GO:0047917 xref: MetaCyc:GDP-GLUCOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007217 name: GDP-mannose 3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose = GDP-L-galactose." [EC:5.1.3.18] synonym: "GDP-D-mannose:GDP-L-galactose epimerase activity" EXACT [EC:5.1.3.18] synonym: "GDPmannose 3,5-epimerase activity" EXACT [EC:5.1.3.18] synonym: "guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity" EXACT [EC:5.1.3.18] xref: EC:5.1.3.18 xref: GO:0047918 xref: MetaCyc:RXN-1882 is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007218 name: GDP-mannose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH." [EC:1.1.1.132, MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "GDP mannose dehydrogenase activity" EXACT [EC:1.1.1.132] synonym: "GDP-D-mannose:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.132] synonym: "GDPmannose 6-dehydrogenase activity" EXACT [EC:1.1.1.132] synonym: "guanosine diphospho-D-mannose dehydrogenase activity" EXACT [EC:1.1.1.132] synonym: "guanosine diphosphomannose dehydrogenase activity" EXACT [EC:1.1.1.132] xref: EC:1.1.1.132 xref: GO:0047919 xref: MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007219 name: geissoschizine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + NADPH." [EC:1.3.1.36, MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN] synonym: "geissoschizine:NADP+ 4,21-oxidoreductase activity" EXACT [EC:1.3.1.36] xref: EC:1.3.1.36 xref: GO:0047920 xref: MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007220 name: aminoglycoside 2'-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 2'-N-acetylaminoglycoside. This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring." [GOC:cb] synonym: "acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] synonym: "acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] synonym: "gentamicin 2'-N-acetyltransferase activity" NARROW [] synonym: "gentamicin acetyltransferase II activity" NARROW [EC:2.3.1.59] synonym: "gentamycin 2'-N-acetyltransferase activity" NARROW [] synonym: "gentamycin acetyltransferase II" RELATED [EC:2.3.1.59] xref: EC:2.3.1.59 xref: GO:0047921 xref: MetaCyc:GENTAMICIN-2 is_a: CCO:F0005513 ! aminoglycoside N-acetyltransferase activity [Term] id: CCO:F0007221 name: gentisate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = maleylpyruvate." [EC:1.13.11.4, MetaCyc:GENTISATE-1] subset: gosubset_prok synonym: "2,5-dihydroxybenzoate dioxygenase activity" EXACT [EC:1.13.11.4] synonym: "gentisate dioxygenase activity" EXACT [EC:1.13.11.4] synonym: "gentisate oxygenase activity" EXACT [EC:1.13.11.4] synonym: "gentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.4] synonym: "gentisic acid oxidase activity" EXACT [EC:1.13.11.4] xref: EC:1.13.11.4 xref: GO:0047922 xref: MetaCyc:GENTISATE-1 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007222 name: gentisate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydroxybenzoate = hydroquinone + CO2." [EC:4.1.1.62, MetaCyc:GENTISATE-DECARBOXYLASE-RXN] synonym: "2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)" EXACT [EC:4.1.1.62] synonym: "2,5-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.62] synonym: "gentisate carboxy-lyase activity" EXACT [EC:4.1.1.62] xref: EC:4.1.1.62 xref: GO:0047923 xref: MetaCyc:GENTISATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007223 name: geraniol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH." [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN] synonym: "geraniol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.183] xref: EC:1.1.1.183 xref: GO:0047924 xref: MetaCyc:GERANIOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007224 name: geranoyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + geranoyl-CoA + HCO3- = ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA." [EC:6.4.1.5, MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN] synonym: "geranoyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.5] synonym: "geranoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.5] synonym: "geranyl-CoA carboxylase activity" EXACT [EC:6.4.1.5] xref: EC:6.4.1.5 xref: GO:0047925 xref: MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN is_a: CCO:F0003144 ! CoA carboxylase activity [Term] id: CCO:F0007225 name: geranyl-diphosphate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (+)-bornyl diphosphate." [EC:5.5.1.8, MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN] synonym: "(+)-bornyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.8] synonym: "(+)-bornylpyrophosphate cyclase activity" EXACT [EC:5.5.1.8] synonym: "bornyl diphosphate synthase activity" EXACT [EC:5.5.1.8] synonym: "bornyl pyrophosphate synthase activity" EXACT [EC:5.5.1.8] synonym: "bornyl pyrophosphate synthetase activity" EXACT [EC:5.5.1.8] xref: EC:5.5.1.8 xref: GO:0047926 xref: MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0007226 name: gibberellin-44 dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2." [EC:1.14.11.12, MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN] synonym: "(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12] synonym: "(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12] synonym: "gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12] synonym: "oxygenase, gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12] xref: EC:1.14.11.12 xref: GO:0047927 xref: MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0007227 name: gibberellin beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside." [EC:2.4.1.176, MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "gibberellin b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176] synonym: "UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176] synonym: "uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.176] synonym: "uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity" EXACT [EC:2.4.1.176] xref: EC:2.4.1.176 xref: GO:0047928 xref: MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007228 name: gluconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.39, MetaCyc:GLUCONATE-DEHYDRATASE-RXN] subset: gosubset_prok synonym: "D-gluconate dehydratase activity" EXACT [EC:4.2.1.39] synonym: "D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.39] synonym: "D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.39] xref: EC:4.2.1.39 xref: GO:0047929 xref: MetaCyc:GLUCONATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007229 name: glucosaminate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3." [EC:4.3.1.9, MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN] comment: Note that this function was EC:4.3.1.21. synonym: "2-amino-2-deoxy-D-gluconate ammonia-lyase activity" EXACT [EC:4.3.1.9] synonym: "2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.9] synonym: "acetylenemonocarboxylic acid hydrase activity" EXACT [EC:4.3.1.9] synonym: "aminodeoxygluconate ammonia-lyase activity" EXACT [] synonym: "aminodeoxygluconate dehydratase activity" EXACT [] synonym: "D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.3.1.9] synonym: "D-glucosaminate ammonia-lyase activity" EXACT [EC:4.3.1.9] synonym: "D-glucosaminate dehydratase activity" EXACT [EC:4.3.1.9] synonym: "D-glucosaminic acid dehydrase activity" EXACT [EC:4.3.1.9] synonym: "glucosaminic dehydrase activity" EXACT [EC:4.3.1.9] xref: EC:4.3.1.9 xref: GO:0047930 xref: GO:0050443 xref: MetaCyc:4.3.1.21-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0007230 name: glucosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate." [EC:2.7.1.8, MetaCyc:GLUCOSAMINE-KINASE-RXN] synonym: "aminodeoxyglucose kinase activity" EXACT [EC:2.7.1.8] synonym: "ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.8] synonym: "ATP:D-glucosamine phosphotransferase activity" EXACT [EC:2.7.1.8] synonym: "glucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.8] xref: EC:2.7.1.8 xref: GO:0047931 xref: MetaCyc:GLUCOSAMINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007231 name: glucosamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine = CoA + N-acetyl-D-glucosamine." [EC:2.3.1.3, MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:D-glucosamine N-acetyltransferase activity" EXACT [EC:2.3.1.3] synonym: "glucosamine acetylase activity" EXACT [EC:2.3.1.3] synonym: "glucosamine acetyltransferase activity" EXACT [EC:2.3.1.3] xref: EC:2.3.1.3 xref: GO:0047932 xref: MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0007232 name: glucose-1,6-bisphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate = 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate." [EC:2.7.1.106, MetaCyc:GLUCOSE-1] synonym: "3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106] synonym: "3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106] synonym: "glucose 1,6-diphosphate synthase activity" EXACT [EC:2.7.1.106] synonym: "glucose-1,6-bisphosphate synthetase activity" EXACT [EC:2.7.1.106] xref: EC:2.7.1.106 xref: GO:0047933 xref: MetaCyc:GLUCOSE-1 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007233 name: glucose 1-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH." [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-(NAD+)-RXN] synonym: "D-aldohexose dehydrogenase activity" EXACT [EC:1.1.1.118] synonym: "D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.118] synonym: "D-glucose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.118] xref: EC:1.1.1.118 xref: GO:0047934 xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-(NAD+)-RXN is_a: CCO:F0007235 ! glucose 1-dehydrogenase activity [Term] id: CCO:F0007234 name: glucose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,4-lactone + NADPH." [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-(NADP+)-RXN] synonym: "D-glucose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.119] synonym: "NADP-dependent glucose dehydrogenase activity" EXACT [EC:1.1.1.119] synonym: "NADP-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119] synonym: "nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119] xref: EC:1.1.1.119 xref: GO:0047935 xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0007235 ! glucose 1-dehydrogenase activity [Term] id: CCO:F0007235 name: glucose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47, MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "beta-D-glucose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.47] synonym: "D-glucose dehydrogenase (NAD(P))" EXACT [EC:1.1.1.47] synonym: "hexose phosphate dehydrogenase activity" EXACT [EC:1.1.1.47] xref: EC:1.1.1.47 xref: GO:0047936 xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007236 name: glucose-1-phosphate phosphodismutase activity namespace: molecular_function def: "Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate." [EC:2.7.1.41, MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN] subset: gosubset_prok synonym: "D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.41] synonym: "glucose 1-phosphate transphosphorylase activity" EXACT [EC:2.7.1.41] synonym: "phosphodismutase activity" EXACT [EC:2.7.1.41] xref: EC:2.7.1.41 xref: GO:0047937 xref: MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007237 name: glucose-6-phosphate 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN] synonym: "D-glucose-6-phosphate 1-epimerase activity" EXACT [EC:5.1.3.15] synonym: "glucose-6 phosphate 1-epimerase activity" EXACT [] xref: EC:5.1.3.15 xref: GO:0047938 xref: MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007238 name: L-glucuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + NADPH." [EC:1.1.1.19, MetaCyc:GLUCURONATE-REDUCTASE-RXN] synonym: "aldehyde reductase II activity" RELATED [EC:1.1.1.19] synonym: "D-glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19] synonym: "D-glucuronate reductase activity" NARROW [EC:1.1.1.19] synonym: "glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19] synonym: "glucuronate reductase activity" EXACT [] synonym: "NADP-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19] synonym: "TPN-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19] xref: EC:1.1.1.19 xref: GO:0047939 xref: MetaCyc:GLUCURONATE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007239 name: glucuronokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucuronate = ADP + 1-phospho-alpha-D-glucuronate." [EC:2.7.1.43, MetaCyc:GLUCURONOKINASE-RXN] synonym: "ATP:D-glucuronate 1-phosphotransferase activity" EXACT [EC:2.7.1.43] synonym: "glucurono-glucuronokinase activity" EXACT [EC:2.7.1.43] synonym: "glucuronokinase (phosphorylating)" EXACT [EC:2.7.1.43] xref: EC:2.7.1.43 xref: GO:0047940 xref: MetaCyc:GLUCURONOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007240 name: glucuronolactone reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + NADPH." [EC:1.1.1.20, MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN] subset: gosubset_prok xref: EC:1.1.1.20 xref: GO:0047941 xref: MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007241 name: glutamate-ethylamine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine." [EC:6.3.1.6, MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN] synonym: "L-glutamate:ethylamine ligase (ADP-forming)" EXACT [EC:6.3.1.6] synonym: "N(5)-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6] synonym: "N5-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6] synonym: "N5-ethylglutamine synthetase activity" EXACT [EC:6.3.1.6] synonym: "theanine synthetase activity" EXACT [EC:6.3.1.6] xref: EC:6.3.1.6 xref: GO:0047942 xref: MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN is_a: CCO:F0003439 ! acid-ammonia (or amide) ligase activity [Term] id: CCO:F0007242 name: glutamate-methylamine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + methylamine = ADP + phosphate + N5-methyl-L-glutamine." [EC:6.3.4.12, MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN] synonym: "gamma-glutamylmethylamide synthetase activity" EXACT [EC:6.3.4.12] synonym: "L-glutamate:methylamine ligase (ADP-forming)" EXACT [EC:6.3.4.12] xref: EC:6.3.4.12 xref: GO:0047943 xref: MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0007243 name: glutamate 1-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate = ADP + alpha-L-glutamyl phosphate." [EC:2.7.2.13, MetaCyc:GLUTAMATE-1-KINASE-RXN] synonym: "ATP:L-glutamate 1-phosphotransferase activity" EXACT [EC:2.7.2.13] xref: EC:2.7.2.13 xref: GO:0047944 xref: MetaCyc:GLUTAMATE-1-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0007244 name: glutamine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine." [EC:2.6.1.15, MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN] subset: gosubset_prok synonym: "gamma-glutaminyltransferase activity" EXACT [EC:2.6.1.15] synonym: "glutaminase II activity" EXACT [EC:2.6.1.15] synonym: "glutamine transaminase activity" EXACT [EC:2.6.1.15] synonym: "glutamine transaminase L activity" EXACT [EC:2.6.1.15] synonym: "glutamine--oxo-acid transaminase activity" EXACT [EC:2.6.1.15] synonym: "glutamine--pyruvate aminotransferase activity" EXACT [] synonym: "glutamine-alpha-keto acid transamidase activity" EXACT [EC:2.6.1.15] synonym: "glutamine-alpha-keto acid transaminase activity" EXACT [EC:2.6.1.15] synonym: "glutamine-keto acid aminotransferase activity" EXACT [EC:2.6.1.15] synonym: "glutamine-oxo acid aminotransferase activity" EXACT [EC:2.6.1.15] synonym: "L-glutamine transaminase L" RELATED [EC:2.6.1.15] synonym: "L-glutamine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.15] xref: EC:2.6.1.15 xref: GO:0047945 xref: MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007245 name: glutamine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine." [EC:2.3.1.68, MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" EXACT [EC:2.3.1.68] xref: EC:2.3.1.68 xref: GO:0047946 xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0007246 name: glutamine N-phenylacetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine." [EC:2.3.1.14, MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN] synonym: "glutamine phenylacetyltransferase activity" EXACT [EC:2.3.1.14] synonym: "phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity" EXACT [EC:2.3.1.14] synonym: "phenylacetyl-CoA:L-glutamine N-acetyltransferase activity" EXACT [EC:2.3.1.14] xref: EC:2.3.1.14 xref: GO:0047947 xref: MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007247 name: glutarate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA." [EC:6.2.1.6, MetaCyc:GLUTARATE--COA-LIGASE-RXN] synonym: "glutarate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.6] synonym: "glutaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.6] synonym: "glutaryl-CoA synthetase activity" EXACT [EC:6.2.1.6] xref: EC:6.2.1.6 xref: GO:0047948 xref: MetaCyc:GLUTARATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007248 name: glutarate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH." [EC:1.2.1.20, MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN] synonym: "glutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.20] synonym: "glutarate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.20] xref: EC:1.2.1.20 xref: GO:0047949 xref: MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007249 name: glutathione oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + O2 = oxidized glutathione + H2O2." [EC:1.8.3.3, MetaCyc:GLUTATHIONE-OXIDASE-RXN] synonym: "glutathione:oxygen oxidoreductase activity" EXACT [EC:1.8.3.3] xref: EC:1.8.3.3 xref: GO:0047950 xref: MetaCyc:GLUTATHIONE-OXIDASE-RXN is_a: CCO:F0003263 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor [Term] id: CCO:F0007250 name: glutathione thiolesterase activity namespace: molecular_function def: "Catalysis of the reaction: S-acylglutathione + H2O = glutathione + a carboxylate." [EC:3.1.2.7, MetaCyc:GLUTATHIONE-THIOESTERASE-RXN] synonym: "citryl-glutathione thioesterhydrolase activity" EXACT [EC:3.1.2.7] synonym: "glutathione thioesterase activity" EXACT [] synonym: "S-acylglutathione hydrolase activity" EXACT [EC:3.1.2.7] xref: EC:3.1.2.7 xref: GO:0047951 xref: MetaCyc:GLUTATHIONE-THIOESTERASE-RXN is_a: CCO:F0003361 ! thiolester hydrolase activity [Term] id: CCO:F0007251 name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN] subset: gosubset_prok synonym: "glycerol 3-phosphate dehydrogenase (NAD(P)) activity" EXACT [EC:1.1.1.94] synonym: "glycerol 3-phosphate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.94] synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.1.1.94] synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT [] synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.94] synonym: "sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.94] xref: EC:1.1.1.94 xref: GO:0047952 xref: MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007252 name: glycerol 2-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NADP+ = glycerone + NADPH." [EC:1.1.1.156, MetaCyc:GLYCEROL-2-DEHYDROGENASE-(NADP+)-RXN] synonym: "DHA oxidoreductase activity" EXACT [EC:1.1.1.156] synonym: "dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.156] synonym: "dihydroxyacetone reductase (NADPH)" EXACT [EC:1.1.1.156] synonym: "dihydroxyacetone reductase activity" EXACT [EC:1.1.1.156] synonym: "glycerol:NADP+ 2-oxidoreductase (glycerone-forming)" EXACT [EC:1.1.1.156] xref: EC:1.1.1.156 xref: GO:0047953 xref: MetaCyc:GLYCEROL-2-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007253 name: glycerol-2-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.19, MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN] synonym: "2-glycerophosphatase activity" EXACT [EC:3.1.3.19] synonym: "beta-glycerophosphatase activity" EXACT [EC:3.1.3.19] synonym: "beta-glycerophosphate phosphatase activity" EXACT [EC:3.1.3.19] synonym: "glycerol-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.19] xref: EC:3.1.3.19 xref: GO:0047954 xref: MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007254 name: glycerol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + acceptor = glycerone + reduced acceptor." [EC:1.1.99.22, MetaCyc:GLYCEROL-DEHYDROGENASE-(ACCEPTOR)-RXN] synonym: "glycerol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.22] synonym: "glycerol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.22] xref: EC:1.1.99.22 xref: GO:0047955 xref: MetaCyc:GLYCEROL-DEHYDROGENASE-(ACCEPTOR)-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007255 name: glycerol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH." [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-(NADP+)-RXN] synonym: "glycerol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.72] xref: EC:1.1.1.72 xref: GO:0047956 xref: MetaCyc:GLYCEROL-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007256 name: 4'-methoxyisoflavone 2'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O." [EC:1.14.13.53, MetaCyc:ISOFLAVONE-2] synonym: "formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.13.53] synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.53] xref: EC:1.14.13.53 xref: GO:0047957 xref: MetaCyc:ISOFLAVONE-2 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007257 name: glycine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate." [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN] synonym: "glutamate-glyoxylate transaminase activity" EXACT [] synonym: "glutamic-glyoxylic transaminase activity" EXACT [EC:2.6.1.4] synonym: "glycine aminotransferase activity" EXACT [] synonym: "glycine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.4] synonym: "glyoxylate-glutamate aminotransferase activity" EXACT [EC:2.6.1.4] synonym: "glyoxylate-glutamic transaminase activity" EXACT [EC:2.6.1.4] synonym: "L-glutamate:glyoxylate aminotransferase activity" EXACT [] xref: EC:2.6.1.4 xref: GO:0047958 xref: MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007258 name: glycine dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c." [EC:1.4.2.1, MetaCyc:GLYCINE-DEHYDROGENASE-(CYTOCHROME)-RXN] synonym: "glycine-cytochrome c reductase activity" EXACT [EC:1.4.2.1] synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" EXACT [EC:1.4.2.1] synonym: "reductase, glycine-cytochrome c" EXACT [EC:1.4.2.1] xref: EC:1.4.2.1 xref: GO:0047959 xref: MetaCyc:GLYCINE-DEHYDROGENASE-(CYTOCHROME)-RXN is_a: CCO:F0003240 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor [Term] id: CCO:F0007259 name: glycine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH." [EC:1.4.1.10, MetaCyc:GLYCINE-DEHYDROGENASE-RXN] synonym: "glycine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.10] xref: EC:1.4.1.10 xref: GO:0047960 xref: MetaCyc:GLYCINE-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007260 name: glycine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine." [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.13] synonym: "glycine acyltransferase activity" EXACT [EC:2.3.1.13] synonym: "glycine-N-acylase activity" EXACT [EC:2.3.1.13] xref: EC:2.3.1.13 xref: GO:0047961 xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0007261 name: glycine N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + glycine = CoA + N-benzoylglycine." [EC:2.3.1.71, MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN] synonym: "benzoyl CoA-amino acid N-acyltransferase activity" EXACT [EC:2.3.1.71] synonym: "benzoyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.71] synonym: "benzoyl-CoA:glycine N-benzoyltransferase activity" EXACT [EC:2.3.1.71] xref: EC:2.3.1.71 xref: GO:0047962 xref: MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007262 name: glycine N-choloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate." [EC:2.3.1.65, MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN] synonym: "amino acid N-choloyltransferase activity" EXACT [EC:2.3.1.65] synonym: "BACAT activity" EXACT [EC:2.3.1.65] synonym: "BAT activity" EXACT [EC:2.3.1.65] synonym: "bile acid-CoA:amino acid N-acyltransferase activity" EXACT [EC:2.3.1.65] synonym: "choloyl-CoA:glycine N-choloyltransferase activity" EXACT [EC:2.3.1.65] synonym: "cholyl-CoA glycine-taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] synonym: "cholyl-CoA:taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] synonym: "glycine--taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] xref: EC:2.3.1.65 xref: GO:0047963 xref: MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007263 name: glyoxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN] subset: gosubset_prok synonym: "glycolate reductase activity" EXACT [] synonym: "glyoxylic acid reductase activity" EXACT [EC:1.1.1.26] synonym: "NADH-dependent glyoxylate reductase activity" EXACT [EC:1.1.1.26] xref: EC:1.1.1.26 xref: GO:0047964 xref: MetaCyc:GLYCOLATE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007264 name: glycoprotein O-fatty-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein." [EC:2.3.1.142, MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN] synonym: "fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity" EXACT [EC:2.3.1.142] synonym: "protein acyltransferase activity" EXACT [EC:2.3.1.142] xref: EC:2.3.1.142 xref: GO:0047965 xref: MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN is_a: CCO:F0003139 ! O-palmitoyltransferase activity [Term] id: CCO:F0007265 name: glycosulfatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + SO4(2-) (sulfate)." [EC:3.1.6.3, MetaCyc:GLYCOSULFATASE-RXN] synonym: "glucosulfatase activity" EXACT [EC:3.1.6.3] synonym: "glycosulphatase activity" EXACT [] synonym: "sugar-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.3] xref: EC:3.1.6.3 xref: GO:0047966 xref: MetaCyc:GLYCOSULFATASE-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0007266 name: glycyrrhizinate beta-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + glycyrrhizinate = 1,2-beta-D-glucuronosyl-D-glucuronate + glycyrrhetinate." [EC:3.2.1.128, MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN] synonym: "glycyrrhizin beta-hydrolase activity" EXACT [EC:3.2.1.128] synonym: "glycyrrhizin hydrolase activity" EXACT [EC:3.2.1.128] synonym: "glycyrrhizinate b-glucuronidase activity" EXACT [] synonym: "glycyrrhizinate glucuronosylhydrolase activity" EXACT [EC:3.2.1.128] synonym: "glycyrrhizinic acid hydrolase activity" EXACT [EC:3.2.1.128] xref: EC:3.2.1.128 xref: GO:0047967 xref: MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007267 name: glyoxylate dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + CoA + NADP+ = oxalyl-CoA + NADPH." [EC:1.2.1.17, MetaCyc:GLYOXYLATE-DEHYDROGENASE-(ACYLATING)-RXN] synonym: "glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)" EXACT [EC:1.2.1.17] xref: EC:1.2.1.17 xref: GO:0047968 xref: MetaCyc:GLYOXYLATE-DEHYDROGENASE-(ACYLATING)-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007268 name: glyoxylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + H2O + O2 = oxalate + H2O2." [EC:1.2.3.5, MetaCyc:GLYOXYLATE-OXIDASE-RXN] synonym: "glyoxylate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.5] xref: EC:1.2.3.5 xref: GO:0047969 xref: MetaCyc:GLYOXYLATE-OXIDASE-RXN is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0007269 name: guanidinoacetase activity namespace: molecular_function def: "Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea." [EC:3.5.3.2, MetaCyc:GUANIDINOACETASE-RXN] synonym: "glycocyaminase activity" EXACT [EC:3.5.3.2] synonym: "guanidinoacetate amidinohydrolase activity" EXACT [EC:3.5.3.2] xref: EC:3.5.3.2 xref: GO:0047970 xref: MetaCyc:GUANIDINOACETASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0007270 name: guanidinobutyrase activity namespace: molecular_function def: "Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea." [EC:3.5.3.7, MetaCyc:GUANIDINOBUTYRASE-RXN] subset: gosubset_prok synonym: "4-guanidinobutanoate amidinohydrolase activity" EXACT [EC:3.5.3.7] synonym: "4-guanidinobutyrate amidinobutyrase activity" EXACT [EC:3.5.3.7] synonym: "G-base activity" EXACT [EC:3.5.3.7] synonym: "gamma-guanidinobutyrate amidinohydrolase activity" EXACT [EC:3.5.3.7] synonym: "gamma-guanidobutyrase activity" EXACT [EC:3.5.3.7] synonym: "GBH" RELATED [EC:3.5.3.7] synonym: "guanidinobutyrate ureahydrolase activity" EXACT [EC:3.5.3.7] xref: EC:3.5.3.7 xref: GO:0047971 xref: MetaCyc:GUANIDINOBUTYRASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0007271 name: guanidinopropionase activity namespace: molecular_function def: "Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea." [EC:3.5.3.17, MetaCyc:GUANIDINOPROPIONASE-RXN] synonym: "3-guanidinopropanoate amidinopropionase activity" EXACT [EC:3.5.3.17] synonym: "GPase activity" EXACT [EC:3.5.3.17] synonym: "GPH" RELATED [EC:3.5.3.17] xref: EC:3.5.3.17 xref: GO:0047972 xref: MetaCyc:GUANIDINOPROPIONASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0007272 name: guanidinoacetate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + guanidinoacetate = ADP + phosphoguanidinoacetate." [EC:2.7.3.1, MetaCyc:GUANIDOACETATE-KINASE-RXN] synonym: "ATP:guanidinoacetate N-phosphotransferase activity" EXACT [EC:2.7.3.1] synonym: "glycocyamine kinase activity" EXACT [EC:2.7.3.1] synonym: "guanidoacetate kinase activity" EXACT [] xref: EC:2.7.3.1 xref: GO:0047973 xref: MetaCyc:GUANIDOACETATE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0007273 name: guanosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN] synonym: "guanosine aminase activity" EXACT [EC:3.5.4.15] synonym: "guanosine aminohydrolase activity" EXACT [EC:3.5.4.15] xref: EC:3.5.4.15 xref: GO:0047974 xref: MetaCyc:GUANOSINE-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0007274 name: guanosine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate." [EC:2.4.2.15, MetaCyc:GUANPHOSPHOR-RXN] synonym: "guanosine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.15] synonym: "guanosine:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.15] xref: EC:2.4.2.15 xref: GO:0047975 xref: MetaCyc:GUANPHOSPHOR-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0007275 name: hamamelose kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate." [EC:2.7.1.102, MetaCyc:HAMAMELOSE-KINASE-RXN] synonym: "ATP/hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102] synonym: "ATP:D-hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102] synonym: "hamamelose kinase (phosphorylating)" EXACT [EC:2.7.1.102] synonym: "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)" EXACT [EC:2.7.1.102] xref: EC:2.7.1.102 xref: GO:0047976 xref: MetaCyc:HAMAMELOSE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007276 name: hepoxilin-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate." [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN] synonym: "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity" EXACT [EC:3.3.2.7] synonym: "hepoxilin A(3) hydrolase activity" RELATED [EC:3.3.2.7] synonym: "hepoxilin A3 hydrolase activity" EXACT [EC:3.3.2.7] synonym: "hepoxilin epoxide hydrolase activity" EXACT [EC:3.3.2.7] synonym: "hepoxylin hydrolase activity" RELATED [EC:3.3.2.7] xref: EC:3.3.2.7 xref: GO:0047977 xref: MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN is_a: CCO:F0003373 ! ether hydrolase activity [Term] id: CCO:F0007277 name: hexadecanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH." [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN] synonym: "hexadecanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.164] xref: EC:1.1.1.164 xref: GO:0047978 xref: MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007278 name: hexose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN] synonym: "D-hexose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.5] xref: EC:1.1.3.5 xref: GO:0047979 xref: MetaCyc:HEXOSE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007279 name: hippurate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: hippurate + H2O = benzoate + glycine." [EC:3.5.1.32, MetaCyc:HIPPURATE-HYDROLASE-RXN] subset: gosubset_prok synonym: "benzoylglycine amidohydrolase activity" EXACT [EC:3.5.1.32] synonym: "hippuricase activity" EXACT [EC:3.5.1.32] synonym: "N-benzoylamino-acid amidohydrolase activity" EXACT [EC:3.5.1.32] xref: EC:3.5.1.32 xref: GO:0047980 xref: MetaCyc:HIPPURATE-HYDROLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007280 name: histidine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-histidine = CoA + N-acetyl-L-histidine." [EC:2.3.1.33, MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:L-histidine N-acetyltransferase activity" EXACT [EC:2.3.1.33] synonym: "acetylhistidine synthetase activity" EXACT [EC:2.3.1.33] synonym: "histidine acetyltransferase activity" EXACT [EC:2.3.1.33] xref: EC:2.3.1.33 xref: GO:0047981 xref: MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0007281 name: homocysteine desulfhydrase activity namespace: molecular_function def: "Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate." [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN] synonym: "homocysteine desulfurase activity" EXACT [EC:4.4.1.2] synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating)" EXACT [EC:4.4.1.2] synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.2] xref: EC:4.4.1.2 xref: GO:0047982 xref: MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0007282 name: homoglutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + beta-alanine = ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine." [EC:6.3.2.23, MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN] synonym: "beta-alanine specific hGSH synthetase activity" EXACT [EC:6.3.2.23] synonym: "gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.23] synonym: "homoglutathione synthetase activity" EXACT [EC:6.3.2.23] xref: EC:6.3.2.23 xref: GO:0047983 xref: MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0007283 name: hydrogen dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2 + NAD+ = H+ + NADH." [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.1.2] synonym: "H(2):NAD(+) oxidoreductase activity" EXACT [EC:1.12.1.2] synonym: "H2:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2] synonym: "hydrogen:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2] synonym: "hydrogenase activity" BROAD [EC:1.12.1.2] synonym: "NAD-linked hydrogenase activity" EXACT [EC:1.12.1.2] xref: EC:1.12.1.2 xref: GO:0047985 xref: MetaCyc:HYDROGEN-DEHYDROGENASE-RXN is_a: CCO:F0003282 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor [Term] id: CCO:F0007284 name: hydrogen-sulfide S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + hydrogen sulfide = CoA + thioacetate." [EC:2.3.1.10, MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity" EXACT [EC:2.3.1.10] synonym: "hydrogen-sulfide acetyltransferase activity" EXACT [EC:2.3.1.10] synonym: "hydrogen-sulphide S-acetyltransferase activity" EXACT [] xref: EC:2.3.1.10 xref: GO:0047986 xref: MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN is_a: CCO:F0003141 ! S-acetyltransferase activity [Term] id: CCO:F0007285 name: hydroperoxide dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate = (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O." [EC:4.2.1.92, MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity" EXACT [EC:4.2.1.92] synonym: "HPI" RELATED [EC:4.2.1.92] synonym: "hydroperoxide isomerase activity" EXACT [EC:4.2.1.92] synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] xref: EC:4.2.1.92 xref: GO:0047987 xref: MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007286 name: hydroxyacid-oxoacid transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN] synonym: "(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity" EXACT [EC:1.1.99.24] synonym: "transhydrogenase, hydroxy acid-oxo acid" EXACT [EC:1.1.99.24] xref: EC:1.1.99.24 xref: GO:0047988 xref: MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007287 name: hydroxybutyrate-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O = 2 (R)-3-hydroxybutanoate." [EC:3.1.1.22, MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN] subset: gosubset_prok synonym: "(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity" EXACT [EC:3.1.1.22] synonym: "D-(-)-3-hydroxybutyrate-dimer hydrolase activity" EXACT [EC:3.1.1.22] xref: EC:3.1.1.22 xref: GO:0047989 xref: MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007288 name: hydroxyglutamate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-L-glutamate = 4-amino-3-hydroxybutanoate + CO2." [EC:4.1.1.16, MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN] synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)" EXACT [EC:4.1.1.16] synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.16] xref: EC:4.1.1.16 xref: GO:0047990 xref: MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007289 name: hydroxylamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxylamine + O2 = NO2(-) (nitrite) + H2O." [EC:1.7.3.4, MetaCyc:HYDROXYLAMINE-OXIDASE-RXN] subset: gosubset_prok synonym: "HAO" RELATED [EC:1.7.3.4] synonym: "hydroxylamine oxidoreductase" BROAD [EC:1.7.3.4] synonym: "hydroxylamine:oxygen oxidoreductase activity" EXACT [EC:1.7.3.4] xref: EC:1.7.3.4 xref: GO:0047991 xref: MetaCyc:HYDROXYLAMINE-OXIDASE-RXN is_a: CCO:F0003258 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: CCO:F0007290 name: hydroxylysine kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine." [EC:2.7.1.81, MetaCyc:HYDROXYLYSINE-KINASE-RXN] synonym: "GTP:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81] synonym: "guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81] synonym: "hydroxylysine kinase (phosphorylating)" EXACT [EC:2.7.1.81] xref: EC:2.7.1.81 xref: GO:0047992 xref: MetaCyc:HYDROXYLYSINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007291 name: hydroxymalonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymalonate + NAD+ = oxomalonate + NADH." [EC:1.1.1.167, MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN] synonym: "hydroxymalonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.167] xref: EC:1.1.1.167 xref: GO:0047993 xref: MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007292 name: hydroxymethylglutaryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = CoA + 3-hydroxy-3-methylglutarate." [EC:3.1.2.5, MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5] synonym: "3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5] synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5] synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5] synonym: "hydroxymethylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5] synonym: "hydroxymethylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5] xref: EC:3.1.2.5 xref: GO:0047994 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0007293 name: hydroxyphenylpyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN] synonym: "4-hydroxyphenyllactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.237] synonym: "HPRP" RELATED [EC:1.1.1.237] xref: EC:1.1.1.237 xref: GO:0047995 xref: MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007294 name: hydroxyphytanate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2." [EC:1.1.3.27, MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN] synonym: "L-2-hydroxyphytanate:oxygen 2-oxidoreductase" BROAD [EC:1.1.3.27] xref: EC:1.1.3.27 xref: GO:0047996 xref: MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007295 name: hydroxypyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxypyruvate = glycolaldehyde + CO2." [EC:4.1.1.40, MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN] synonym: "hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)" EXACT [EC:4.1.1.40] synonym: "hydroxypyruvate carboxy-lyase activity" EXACT [EC:4.1.1.40] xref: EC:4.1.1.40 xref: GO:0047997 xref: MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007296 name: hyoscyamine (6S)-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2." [EC:1.14.11.11, MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN] synonym: "hyoscyamine (6S)-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6-beta-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6beta-dioxygenase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6beta-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)" EXACT [EC:1.14.11.11] xref: EC:1.14.11.11 xref: GO:0047998 xref: MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0007297 name: hyponitrite reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = hyponitrous acid + 2 NADH + 2 H+." [EC:1.7.1.5, MetaCyc:HYPONITRITE-REDUCTASE-RXN] synonym: "hydroxylamine:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.5] synonym: "NADH2:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5] synonym: "NADH:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5] xref: EC:1.7.1.5 xref: GO:0047999 xref: MetaCyc:HYPONITRITE-REDUCTASE-RXN is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0007298 name: isoflavone 3'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O." [EC:1.14.13.52, MetaCyc:ISOFLAVONE-3] synonym: "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.52] synonym: "isoflavone 3'-monooxygenase activity" EXACT [EC:1.14.13.52] xref: EC:1.14.13.52 xref: GO:0048000 xref: MetaCyc:RXN-3762 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007299 name: erythrose-4-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH + 2 H+." [EC:1.2.1.72, MetaCyc:ERYTH4PDEHYDROG-RXN] synonym: "D-erythrose 4-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.72] synonym: "E4P dehydrogenase activity" EXACT [EC:1.2.1.72] synonym: "E4PDH" EXACT [EC:1.2.1.72] synonym: "Epd dehydrogenase activity" EXACT [EC:1.2.1.72] synonym: "erythrose 4-phosphate dehydrogenase activity" EXACT [EC:1.2.1.72] synonym: "GapB" RELATED [EC:1.2.1.72] xref: EC:1.2.1.72 xref: GO:0033724 xref: GO:0048001 xref: MetaCyc:ERYTH4PDEHYDROG-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007300 name: receptor agonist activity namespace: molecular_function def: "Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0048018 is_a: CCO:F0001407 ! receptor binding is_a: CCO:F0004458 ! receptor activator activity [Term] id: CCO:F0007301 name: receptor antagonist activity namespace: molecular_function def: "Interacts with receptors to reduce the action of another ligand, the agonist." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0048019 is_a: CCO:F0001407 ! receptor binding is_a: CCO:F0004459 ! receptor inhibitor activity [Term] id: CCO:F0007302 name: CCR chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a CCR chemokine receptor." [GOC:ai] synonym: "beta chemokine receptor binding" EXACT [] synonym: "beta chemokine receptor ligand" NARROW [] synonym: "CCR chemokine receptor ligand" NARROW [] xref: GO:0048020 is_a: CCO:F0005665 ! chemokine receptor binding [Term] id: CCO:F0007303 name: mRNA 5'-UTR binding namespace: molecular_function def: "Interacting selectively with the 5' untranslated region of an mRNA molecule." [GOC:jic] subset: gosubset_prok synonym: "mRNA 5' UTR binding" EXACT [] xref: GO:0048027 is_a: CCO:F0000313 ! mRNA binding [Term] id: CCO:F0007304 name: galacturonan binding namespace: molecular_function def: "Interacting selectively with any simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins." [GOC:jic] subset: gosubset_prok synonym: "polygalacturonide binding" RELATED [] xref: GO:0048028 is_a: CCO:F0004357 ! polysaccharide binding [Term] id: CCO:F0007305 name: monosaccharide binding namespace: molecular_function def: "Interacting selectively with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jic] subset: gosubset_prok xref: GO:0048029 is_a: CCO:F0001659 ! sugar binding [Term] id: CCO:F0007306 name: disaccharide binding namespace: molecular_function def: "Interacting selectively with any disaccharide. Disaccharides are sugars composed of two monosaccharide units." [GOC:jic] xref: GO:0048030 is_a: CCO:F0001659 ! sugar binding [Term] id: CCO:F0007307 name: trisaccharide binding namespace: molecular_function def: "Interacting selectively with any trisaccharide. Trisaccharides are sugars composed of three monosaccharide units." [GOC:jic] xref: GO:0048031 is_a: CCO:F0001659 ! sugar binding [Term] id: CCO:F0007308 name: galacturonate binding namespace: molecular_function def: "Interacting selectively with any galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:jic] synonym: "galacturonic acid binding" EXACT [] xref: GO:0048032 is_a: CCO:F0007305 ! monosaccharide binding [Term] id: CCO:F0007309 name: cofactor binding namespace: molecular_function def: "Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok xref: GO:0048037 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0007310 name: quinone binding namespace: molecular_function def: "Interacting selectively with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0048038 is_a: CCO:F0007309 ! cofactor binding [Term] id: CCO:F0007311 name: ubiquinone binding namespace: molecular_function def: "Interacting selectively with ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jic, ISBN:0582227089] subset: gosubset_prok synonym: "coenzyme Q binding" EXACT [] synonym: "coenzyme Q6 binding" NARROW [] xref: GO:0048039 is_a: CCO:F0007310 ! quinone binding [Term] id: CCO:F0007312 name: UDP-glucuronate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucuronic acid = UDP-D-xylose + CO2." [EC:4.1.1.35, PMID:11593010] synonym: "UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)" EXACT [EC:4.1.1.35] synonym: "UDP-D-glucuronate carboxy-lyase activity" EXACT [EC:4.1.1.35] synonym: "UDP-glucuronic acid decarboxylase activity" EXACT [] synonym: "UDPglucuronate decarboxylase activity" EXACT [EC:4.1.1.35] synonym: "uridine-diphosphoglucuronate decarboxylase activity" EXACT [EC:4.1.1.35] xref: EC:4.1.1.35 xref: GO:0048040 xref: MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007313 name: trans-pentaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-hexaprenyl diphosphate." [EC:2.5.1.33] subset: gosubset_prok synonym: "all-trans-hexaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.33] synonym: "all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity" EXACT [EC:2.5.1.33] synonym: "hexaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.33] synonym: "hexaprenyl pyrophosphate synthetase activity" EXACT [] xref: EC:2.5.1.33 xref: GO:0048045 xref: MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007314 name: calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive." [GOC:jic] synonym: "calcium- and calmodulin-regulated cGMP phosphodiesterase activity" RELATED [] synonym: "calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] synonym: "calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity" EXACT [] synonym: "calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] xref: GO:0048101 is_a: CCO:F0006858 ! 3',5'-cyclic-GMP phosphodiesterase activity [Term] id: CCO:F0007315 name: S100 beta binding namespace: molecular_function def: "Interacting selectively with S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic] xref: GO:0048154 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0007316 name: S100 alpha binding namespace: molecular_function def: "Interacting selectively with S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic] xref: GO:0048155 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0007317 name: tau protein binding namespace: molecular_function def: "Interacting selectively with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic] xref: GO:0048156 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0007318 name: follistatin binding namespace: molecular_function def: "Interacting selectively with follistatin." [GOC:jic] xref: GO:0048184 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0007319 name: activin binding namespace: molecular_function def: "Interacting selectively with activin." [GOC:jic] xref: GO:0048185 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0007320 name: inhibin beta-A binding namespace: molecular_function def: "Interacting selectively with inhibin beta-A." [GOC:jic] xref: GO:0048186 is_a: CCO:F0007318 ! follistatin binding is_a: CCO:F0007319 ! activin binding [Term] id: CCO:F0007321 name: inhibin beta-B binding namespace: molecular_function def: "Interacting selectively with inhibin beta-B." [GOC:jic] xref: GO:0048187 is_a: CCO:F0007318 ! follistatin binding is_a: CCO:F0007319 ! activin binding [Term] id: CCO:F0007322 name: phytanoyl-CoA dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2." [EC:1.14.11.18, GOC:jic] synonym: "phytanoyl-CoA 2 oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA 2-hydroxylase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA alpha-hydroxylase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA hydroxylase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.11.18] xref: EC:1.14.11.18 xref: GO:0048244 xref: MetaCyc:1.14.11.18-RXN is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0007323 name: CXCR3 chemokine receptor binding namespace: molecular_function def: "Interacting selectively with a the CXCR3 chemokine receptor." [GOC:jic, PMID:10556837] xref: GO:0048248 is_a: CCO:F0006097 ! CXCR chemokine receptor binding [Term] id: CCO:F0007324 name: high affinity phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphate from one side of the membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jic, PMID:8709965] xref: GO:0048249 is_a: CCO:F0002592 ! phosphate transmembrane transporter activity [Term] id: CCO:F0007325 name: flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jic] subset: gosubset_prok xref: EC:3.1.-.-. xref: GO:0048256 is_a: CCO:F0000917 ! endodeoxyribonuclease activity [Term] id: CCO:F0007326 name: 3'-flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jic, PMID:10635319] synonym: "3' flap endonuclease activity" EXACT [] xref: GO:0048257 is_a: CCO:F0003447 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters is_a: CCO:F0007325 ! flap endonuclease activity [Term] id: CCO:F0007327 name: 3-ketoglucose-reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose." [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN] xref: EC:1.1.1.- xref: GO:0048258 xref: MetaCyc:KETOGLUCOSE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007328 name: methionine adenosyltransferase regulator activity namespace: molecular_function def: "Modulates the activity of methionine adenosyltransferase." [EC:2.5.1.6, GOC:jic, PMID:10644686] comment: See also the molecular function term 'methionine adenosyltransferase activity ; GO:0004478'. synonym: "MAT regulator activity" EXACT [] xref: GO:0048270 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0007329 name: mitogen-activated protein kinase p38 binding namespace: molecular_function def: "Interacting selectively with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation." [http://cancerweb.ncl.ac.uk] synonym: "MAPK p38 binding" EXACT [] xref: GO:0048273 is_a: CCO:F0008037 ! mitogen-activated protein kinase binding [Term] id: CCO:F0007330 name: calcium-dependent protein binding namespace: molecular_function def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium." [GOC:jic, PMID:10485905] xref: GO:0048306 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0007331 name: ferredoxin-nitrite reductase activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = NO2(-) (nitrite) + 6 reduced ferredoxin + 7 H+." [EC:1.7.7.1, GOC:jic] subset: gosubset_prok synonym: "ammonia:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.1] xref: EC:1.7.7.1 xref: GO:0048307 is_a: CCO:F0003259 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor [Term] id: CCO:F0007332 name: Rac GTPase binding namespace: molecular_function def: "Interacting selectively with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases." [GOC:ebc, PMID:11702775] xref: GO:0048365 is_a: CCO:F0003531 ! Rho GTPase binding [Term] id: CCO:F0007333 name: brain-derived neurotrophic factor binding namespace: molecular_function def: "Interacting selectively with brain-derived neurotrophic factor." [GOC:dgh] synonym: "BDNF binding" EXACT [] synonym: "neurotrophin TRKB receptor activity" RELATED [] xref: GO:0048403 is_a: CCO:F0005795 ! neurotrophin binding [Term] id: CCO:F0007334 name: neurotrophin-3 binding namespace: molecular_function def: "Interacting selectively with neurotrophin-3." [GOC:dgh] synonym: "neurotrophin 3 binding" EXACT [] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "neurotrophin TRKC receptor activity" RELATED [] synonym: "NT-3 binding" EXACT [] synonym: "NT3 binding" EXACT [] xref: GO:0048404 is_a: CCO:F0005795 ! neurotrophin binding [Term] id: CCO:F0007335 name: neurotrophin-4/5 binding namespace: molecular_function def: "Interacting selectively with neurotrophin-4/5." [GOC:dgh] comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858]. synonym: "neurotrophin 4/5 binding" EXACT [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "NT 4/5 binding" EXACT [] synonym: "NT-4 binding" NARROW [] synonym: "NT-4/5 binding" EXACT [] synonym: "NT-5 binding" NARROW [] synonym: "NT4 binding" NARROW [] synonym: "NT5 binding" NARROW [] xref: GO:0048405 is_a: CCO:F0005795 ! neurotrophin binding [Term] id: CCO:F0007336 name: nerve growth factor binding namespace: molecular_function def: "Interacting selectively with nerve growth factor." [GOC:dgh] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "NGF binding" EXACT [] xref: GO:0048406 is_a: CCO:F0005795 ! neurotrophin binding [Term] id: CCO:F0007337 name: platelet-derived growth factor binding namespace: molecular_function def: "Interacting selectively with platelet-derived growth factor." [GOC:dgh] synonym: "PDGF binding" EXACT [] xref: GO:0048407 is_a: CCO:F0004188 ! growth factor binding [Term] id: CCO:F0007338 name: epidermal growth factor binding namespace: molecular_function def: "Interacting selectively with epidermal growth factor." [GOC:dgh] synonym: "EGF binding" EXACT [] xref: GO:0048408 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0007339 name: threonine-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2." [EC:4.1.1.81, GOC:mlg] subset: gosubset_prok synonym: "CobD" RELATED [EC:4.1.1.81] synonym: "L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]" RELATED [EC:4.1.1.81] synonym: "L-threonine O-3-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.81] synonym: "L-threonine-O-3-phosphate decarboxylase activity" EXACT [] xref: EC:4.1.1.81 xref: GO:0048472 is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007340 name: D-methionine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-methionine from one side of a membrane to the other." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-methionine transporter activity" BROAD [] xref: GO:0048474 is_a: CCO:F0006027 ! methionine transmembrane transporter activity [Term] id: CCO:F0007341 name: beta-tubulin binding namespace: molecular_function def: "Interacting selectively with the microtubule constituent protein beta-tubulin." [GOC:krc] synonym: "beta tubulin binding" EXACT [] xref: GO:0048487 is_a: CCO:F0002987 ! tubulin binding [Term] id: CCO:F0007342 name: Roundabout binding namespace: molecular_function def: "Interacting selectively with the Roundabout (ROBO) receptor, a transmembrane receptor." [GOC:ecd, PMID:10102268, PMID:10197527] synonym: "Roundabout receptor binding" RELATED [] xref: GO:0048495 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0007343 name: thiamin-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + thiamin(out) = ADP + phosphate + thiamin(in)." [GOC:mlg, PMID:9535878] comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. synonym: "thiamin ABC transporter" NARROW [] synonym: "thiamine-transporting ATPase activity" EXACT [] xref: GO:0048502 is_a: CCO:F0005699 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: CCO:F0007344 name: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity namespace: molecular_function def: "Catalysis of the reaction: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O." [EC:1.14.13.81] synonym: "magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.81] synonym: "Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity" EXACT [EC:1.14.13.81] synonym: "Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity" EXACT [EC:1.14.13.81] xref: EC:1.14.13.81 xref: GO:0048529 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007345 name: beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage." [PMID:11551958] xref: GO:0048531 is_a: CCO:F0001853 ! galactosyltransferase activity [Term] id: CCO:F0007346 name: metalloenzyme inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc] xref: GO:0048551 is_a: CCO:F0001213 ! enzyme inhibitor activity is_a: CCO:F0008375 ! metalloenzyme regulator activity [Term] id: CCO:F0007347 name: fibroblast growth factor 1 binding namespace: molecular_function def: "Interacting selectively with fibroblast growth factor 1." [GOC:ebc] synonym: "FGF 1 binding" EXACT [] xref: GO:0048602 is_a: CCO:F0003590 ! fibroblast growth factor binding [Term] id: CCO:F0007348 name: fibroblast growth factor 2 binding namespace: molecular_function def: "Interacting selectively with fibroblast growth factor 2." [GOC:ebc] synonym: "FGF 2 binding" EXACT [] xref: GO:0048603 is_a: CCO:F0003590 ! fibroblast growth factor binding [Term] id: CCO:F0007349 name: fibroblast growth factor 3 binding namespace: molecular_function def: "Interacting selectively with fibroblast growth factor 3." [GOC:ebc] synonym: "FGF 3 binding" EXACT [] xref: GO:0048604 is_a: CCO:F0003590 ! fibroblast growth factor binding [Term] id: CCO:F0007350 name: fibroblast growth factor 4 binding namespace: molecular_function def: "Interacting selectively with fibroblast growth factor 4." [GOC:ebc] synonym: "FGF 4 binding" EXACT [] xref: GO:0048605 is_a: CCO:F0003590 ! fibroblast growth factor binding [Term] id: CCO:F0007351 name: fibroblast growth factor 5 binding namespace: molecular_function def: "Interacting selectively with fibroblast growth factor 5." [GOC:ebc] synonym: "FGF 5 binding" EXACT [] xref: GO:0048606 is_a: CCO:F0003590 ! fibroblast growth factor binding [Term] id: CCO:F0007352 name: fibroblast growth factor 6 binding namespace: molecular_function def: "Interacting selectively with fibroblast growth factor 6." [GOC:ebc] synonym: "FGF 6 binding" EXACT [] xref: GO:0048607 is_a: CCO:F0003590 ! fibroblast growth factor binding [Term] id: CCO:F0007353 name: calcium-induced calcium release activity namespace: molecular_function def: "Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration." [GOC:jic, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752] xref: GO:0048763 is_a: CCO:F0001494 ! intracellular ligand-gated calcium channel activity [Term] id: CCO:F0007354 name: D-glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate." [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN] synonym: "D-glutamine amidohydrolase activity" EXACT [EC:3.5.1.35] xref: EC:3.5.1.35 xref: GO:0050001 xref: MetaCyc:D-GLUTAMINASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007355 name: D-proline reductase (dithiol) activity namespace: molecular_function def: "Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline." [EC:1.21.4.1, MetaCyc:D-PROLINE-REDUCTASE-(DITHIOL)-RXN] comment: Note that this function was formerly EC:1.4.4.1. synonym: "5-aminopentanoate:lipoate oxidoreductase (cyclizing)" EXACT [EC:1.21.4.1] xref: EC:1.21.4.1 xref: GO:0050002 xref: MetaCyc:1.21.4.1-RXN is_a: CCO:F0007826 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: CCO:F0007356 name: deoxycytidylate C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = deoxy-5-methylcytidylate + 7,8-dihydrofolate." [EC:2.1.1.54, MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN] synonym: "5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity" EXACT [EC:2.1.1.54] synonym: "dCMP methyltransferase activity" EXACT [EC:2.1.1.54] synonym: "deoxycytidylate methyltransferase activity" EXACT [EC:2.1.1.54] xref: EC:2.1.1.54 xref: GO:0050003 xref: MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN is_a: CCO:F0001756 ! C-methyltransferase activity [Term] id: CCO:F0007357 name: isoflavone 7-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside." [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "UDPglucose-favonoid 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] xref: EC:2.4.1.170 xref: GO:0050004 xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007358 name: isohexenylglutaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)-pent-2-enedioyl-CoA + H2O." [EC:4.2.1.57, MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]" RELATED [EC:4.2.1.57] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.57] synonym: "3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity" EXACT [EC:4.2.1.57] synonym: "beta-isohexenylglutaconyl-CoA-hydratase activity" EXACT [EC:4.2.1.57] synonym: "isohexenylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.57] xref: EC:4.2.1.57 xref: GO:0050005 xref: MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007359 name: isomaltulose synthase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose." [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN] synonym: "isomaltulose synthetase activity" EXACT [EC:5.4.99.11] synonym: "sucrose alpha-glucosyltransferase activity" EXACT [EC:5.4.99.11] synonym: "sucrose glucosylmutase activity" EXACT [EC:5.4.99.11] synonym: "trehalulose synthase activity" EXACT [EC:5.4.99.11] xref: EC:5.4.99.11 xref: GO:0050006 xref: MetaCyc:ISOMALTULOSE-SYNTHASE-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0007360 name: isonocardicin synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + nocardicin E = 5'-methylthioadenosine + isonocardicin A." [EC:2.5.1.38, MetaCyc:ISONOCARDICIN-SYNTHASE-RXN] synonym: "nocardicin aminocarboxypropyltransferase activity" EXACT [EC:2.5.1.38] synonym: "S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.38] xref: EC:2.5.1.38 xref: GO:0050007 xref: MetaCyc:ISONOCARDICIN-SYNTHASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007361 name: isopiperitenone delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: isopiperitenone = piperitenone." [EC:5.3.3.11, MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN] synonym: "isopiperitenone D-isomerase activity" EXACT [] synonym: "isopiperitenone delta8-delta4-isomerase activity" EXACT [EC:5.3.3.11] xref: EC:5.3.3.11 xref: GO:0050008 xref: MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0007362 name: isopropanol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: propan-2-ol + NADP+ = acetone + NADPH." [EC:1.1.1.80, MetaCyc:ISOPROPANOL-DEHYDROGENASE-(NADP+)-RXN] synonym: "propan-2-ol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.80] xref: EC:1.1.1.80 xref: GO:0050009 xref: MetaCyc:ISOPROPANOL-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007363 name: isovitexin beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + isovitexin = isovitexin 2''-O-beta-D-glucoside + UDP." [EC:2.4.1.106, MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "isovitexin b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106] synonym: "UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106] synonym: "uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.106] xref: EC:2.4.1.106 xref: GO:0050010 xref: MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007364 name: itaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O." [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN] synonym: "citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" EXACT [EC:4.2.1.56] synonym: "citramalyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.56] synonym: "itaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.56] xref: EC:4.2.1.56 xref: GO:0050011 xref: MetaCyc:ITACONYL-COA-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007365 name: juglone 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxy-1,4-naphthoquinone + donor-H2 + O2 = 3,5-dihydroxy-1,4-naphthoquinone + acceptor + H2O." [EC:1.14.99.27, MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN] synonym: "5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.99.27] synonym: "juglone hydroxylase activity" EXACT [] synonym: "naphthoquinone hydroxylase activity" EXACT [EC:1.14.99.27] synonym: "naphthoquinone-hydroxylase activity" EXACT [EC:1.14.99.27] xref: EC:1.14.99.27 xref: GO:0050012 xref: MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007366 name: 2-dehydropantoate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde." [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN] synonym: "2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.1.2.12] synonym: "2-dehydropantoate formaldehyde-lyase activity" EXACT [EC:4.1.2.12] synonym: "ketopantoaldolase activity" EXACT [] xref: EC:4.1.2.12 xref: GO:0050013 xref: MetaCyc:KETOPANTOALDOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007367 name: ketotetrose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: erythrulose 1-phosphate = glycerone phosphate + formaldehyde." [EC:4.1.2.2, MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN] synonym: "erythrose-1-phosphate synthase activity" EXACT [EC:4.1.2.2] synonym: "erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.2] synonym: "erythrulose-1-phosphate formaldehyde-lyase activity" EXACT [EC:4.1.2.2] synonym: "erythrulose-1-phosphate synthetase activity" EXACT [EC:4.1.2.2] synonym: "phosphoketotetrose aldolase activity" EXACT [EC:4.1.2.2] xref: EC:4.1.2.2 xref: GO:0050014 xref: MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007368 name: kievitone hydratase activity namespace: molecular_function def: "Catalysis of the reaction: kievitone hydrate = kievitone + H2O." [EC:4.2.1.95, MetaCyc:KIEVITONE-HYDRATASE-RXN] synonym: "KHase activity" EXACT [EC:4.2.1.95] synonym: "kievitone-hydrate hydro-lyase (kievitone-forming)" EXACT [EC:4.2.1.95] synonym: "kievitone-hydrate hydro-lyase activity" EXACT [EC:4.2.1.95] xref: EC:4.2.1.95 xref: GO:0050015 xref: MetaCyc:KIEVITONE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007369 name: kynurenine 7,8-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor." [EC:1.14.99.2, MetaCyc:KYNURENINE-7] synonym: "kynurenate 7,8-hydroxylase activity" EXACT [EC:1.14.99.2] synonym: "kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.2] synonym: "kynurenic acid hydroxylase activity" EXACT [EC:1.14.99.2] synonym: "kynurenic hydroxylase activity" EXACT [EC:1.14.99.2] xref: EC:1.14.99.2 xref: GO:0050016 xref: MetaCyc:KYNURENINE-7 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007370 name: L-3-cyanoalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine." [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN] synonym: "beta-cyano-L-alanine synthase activity" EXACT [EC:4.4.1.9] synonym: "beta-cyanoalanine synthase activity" EXACT [EC:4.4.1.9] synonym: "beta-cyanoalanine synthetase activity" EXACT [EC:4.4.1.9] synonym: "L-cysteine hydrogen-sulfide-lyase (adding HCN)" EXACT [EC:4.4.1.9] synonym: "L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)" EXACT [EC:4.4.1.9] xref: EC:4.4.1.9 xref: GO:0050017 xref: MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0007371 name: L-amino-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." [EC:1.4.1.5, MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN] synonym: "L-amino-acid:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.5] xref: EC:1.4.1.5 xref: GO:0050018 xref: MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007372 name: L-arabinitol 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + NADH." [EC:1.1.1.12, MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN] xref: EC:1.1.1.12 xref: GO:0050019 xref: MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007373 name: L-arabinonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O." [EC:4.2.1.25, MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN] synonym: "L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)" EXACT [EC:4.2.1.25] synonym: "L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.25] synonym: "L-arabonate dehydrase activity" EXACT [EC:4.2.1.25] synonym: "L-arabonate dehydratase activity" EXACT [EC:4.2.1.25] xref: EC:4.2.1.25 xref: GO:0050020 xref: MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007374 name: L-arabinonolactonase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinono-1,4-lactone + H2O = L-arabinonate." [EC:3.1.1.15, MetaCyc:L-ARABINONOLACTONASE-RXN] synonym: "L-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.15] xref: EC:3.1.1.15 xref: GO:0050021 xref: MetaCyc:L-ARABINONOLACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007375 name: L-arabinose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH." [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN] synonym: "L-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.46] xref: EC:1.1.1.46 xref: GO:0050022 xref: MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007376 name: L-fuconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O." [EC:4.2.1.68, MetaCyc:L-FUCONATE-HYDRATASE-RXN] synonym: "L-fuconate hydratase activity" EXACT [] synonym: "L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)" EXACT [EC:4.2.1.68] synonym: "L-fuconate hydro-lyase activity" EXACT [EC:4.2.1.68] xref: EC:4.2.1.68 xref: GO:0050023 xref: MetaCyc:L-FUCONATE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007377 name: L-galactonolactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2." [EC:1.3.3.12, MetaCyc:L-GALACTONOLACTONE-OXIDASE-RXN] synonym: "L-galactono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12] synonym: "L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.3.3.12] synonym: "L-xylono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12] xref: EC:1.3.3.12 xref: GO:0033733 xref: GO:0050024 xref: MetaCyc:L-GALACTONOLACTONE-OXIDASE-RXN is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007378 name: L-glutamate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.11, MetaCyc:L-GLUTAMATE-OXIDASE-RXN] subset: gosubset_prok synonym: "glutamate (acceptor) dehydrogenase activity" EXACT [EC:1.4.3.11] synonym: "glutamate oxidase activity" EXACT [EC:1.4.3.11] synonym: "glutamic acid oxidase activity" EXACT [EC:1.4.3.11] synonym: "glutamic dehydrogenase (acceptor)" EXACT [EC:1.4.3.11] synonym: "L-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.11] synonym: "L-glutamic acid oxidase activity" EXACT [EC:1.4.3.11] xref: EC:1.4.3.11 xref: GO:0050025 xref: MetaCyc:L-GLUTAMATE-OXIDASE-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0007379 name: L-glycol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+." [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN] synonym: "glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.185] synonym: "L-(+)-glycol:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.185] synonym: "L-glycol:NAD(P) dehydrogenase activity" EXACT [EC:1.1.1.185] synonym: "L-glycol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.185] xref: EC:1.1.1.185 xref: GO:0050026 xref: MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007380 name: L-idonate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH." [EC:1.1.1.128, MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN] synonym: "5-keto-D-gluconate 2-reductase activity" EXACT [EC:1.1.1.128] synonym: "5-ketogluconate 2-reductase activity" EXACT [EC:1.1.1.128] synonym: "5-ketoglucono-idono-reductase activity" EXACT [EC:1.1.1.128] synonym: "5KGR" RELATED [EC:1.1.1.128] synonym: "L-idonate dehydrogenase activity" EXACT [EC:1.1.1.128] synonym: "L-idonate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.128] synonym: "reductase, 5-ketogluconate 5- (L-idonate-forming)" EXACT [EC:1.1.1.128] xref: EC:1.1.1.128 xref: GO:0050027 xref: MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007381 name: L-lysine-lactamase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine 1,6-lactam + H2O = L-lysine." [EC:3.5.2.11, MetaCyc:L-LYSINE-LACTAMASE-RXN] synonym: "L-alpha-aminocaprolactam hydrolase activity" EXACT [EC:3.5.2.11] synonym: "L-lysinamidase activity" EXACT [EC:3.5.2.11] synonym: "L-lysine-1,6-lactam lactamhydrolase activity" EXACT [EC:3.5.2.11] xref: EC:3.5.2.11 xref: GO:0050028 xref: MetaCyc:L-LYSINE-LACTAMASE-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0007382 name: L-lysine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2." [EC:1.4.3.14, MetaCyc:L-LYSINE-OXIDASE-RXN] synonym: "L-lysine alpha-oxidase activity" EXACT [EC:1.4.3.14] synonym: "L-lysine:oxygen 2-oxidoreductase (deaminating)" EXACT [EC:1.4.3.14] synonym: "L-lysyl-alpha-oxidase activity" EXACT [EC:1.4.3.14] xref: EC:1.4.3.14 xref: GO:0050029 xref: MetaCyc:L-LYSINE-OXIDASE-RXN xref: MetaCyc:PWY-5311 is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0007383 name: L-pipecolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-pipecolate + acceptor = 2,3,4,5-tetrahydropyridine-2-carboxylate + reduced acceptor." [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN] synonym: "L-pipecolate:(acceptor) 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3] synonym: "L-pipecolate:acceptor 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3] xref: EC:1.5.99.3 xref: GO:0050030 xref: MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0007384 name: L-pipecolate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2." [EC:1.5.3.7, MetaCyc:L-PIPECOLATE-OXIDASE-RXN] synonym: "L-pipecolate:oxygen 1,6-oxidoreductase activity" EXACT [EC:1.5.3.7] synonym: "L-pipecolic acid oxidase activity" EXACT [EC:1.5.3.7] xref: EC:1.5.3.7 xref: GO:0050031 xref: MetaCyc:L-PIPECOLATE-OXIDASE-RXN is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0007385 name: L-rhamnonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O." [EC:4.2.1.90, MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN] synonym: "L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)" EXACT [EC:4.2.1.90] synonym: "L-rhamnonate hydro-lyase activity" EXACT [EC:4.2.1.90] xref: EC:4.2.1.90 xref: GO:0050032 xref: MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007386 name: L-rhamnono-1,4-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate." [EC:3.1.1.65, MetaCyc:L-RHAMNONO-1] synonym: "L-rhamno-gamma-lactonase activity" EXACT [EC:3.1.1.65] synonym: "L-rhamnono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.65] synonym: "L-rhamnono-gamma-lactonase activity" EXACT [EC:3.1.1.65] xref: EC:3.1.1.65 xref: GO:0050033 xref: MetaCyc:L-RHAMNONO-1 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007387 name: L-rhamnose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamno-1,4-lactone + NADH." [EC:1.1.1.173, MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN] synonym: "L-rhamnofuranose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.173] xref: EC:1.1.1.173 xref: GO:0050034 xref: MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007388 name: L-sorbose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2." [EC:1.1.3.11, MetaCyc:L-SORBOSE-OXIDASE-RXN] synonym: "L-sorbose:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.11] xref: EC:1.1.3.11 xref: GO:0050035 xref: MetaCyc:L-SORBOSE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007389 name: L-threonate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + NADH." [EC:1.1.1.129, MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN] synonym: "L-threonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.129] synonym: "L-threonic acid dehydrogenase activity" EXACT [EC:1.1.1.129] synonym: "threonate dehydrogenase activity" EXACT [EC:1.1.1.129] xref: EC:1.1.1.129 xref: GO:0050036 xref: MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007390 name: L-xylose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-xylose + NADP+ = L-xylono-1,4-lactone + NADPH." [EC:1.1.1.113, MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN] synonym: "L-xylose dehydrogenase activity" EXACT [EC:1.1.1.113] synonym: "L-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.113] synonym: "NADPH-xylose reductase activity" EXACT [EC:1.1.1.113] xref: EC:1.1.1.113 xref: GO:0050037 xref: MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007391 name: L-xylulose reductase activity namespace: molecular_function def: "Catalysis of the reaction: xylitol + NADP+ = L-xylulose + NADPH." [EC:1.1.1.10, MetaCyc:L-XYLULOSE-REDUCTASE-RXN] xref: EC:1.1.1.10 xref: GO:0050038 xref: MetaCyc:L-XYLULOSE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007392 name: lactaldehyde reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,2-diol + NADP+ = L-lactaldehyde + NADPH." [EC:1.1.1.55, MetaCyc:LACTALDEHYDE-REDUCTASE-(NADPH)-RXN] synonym: "1,2-propanediol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55] synonym: "lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.55] synonym: "NADP-1,2-propanediol dehydrogenase activity" EXACT [EC:1.1.1.55] synonym: "propane-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55] synonym: "propanediol dehydrogenase activity" EXACT [EC:1.1.1.55] xref: EC:1.1.1.55 xref: GO:0050039 xref: MetaCyc:LACTALDEHYDE-REDUCTASE-(NADPH)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007393 name: lactate 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O." [EC:1.13.12.4, MetaCyc:LACTATE-2-MONOOXYGENASE-RXN] subset: gosubset_prok synonym: "(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.4] synonym: "L-lactate monooxygenase activity" EXACT [EC:1.13.12.4] synonym: "L-lactate-2-monooxygenase activity" EXACT [EC:1.13.12.4] synonym: "lactate monooxygenase activity" EXACT [EC:1.13.12.4] synonym: "lactate oxidase activity" EXACT [EC:1.13.12.4] synonym: "lactate oxidative decarboxylase activity" EXACT [EC:1.13.12.4] synonym: "lactate oxygenase activity" EXACT [EC:1.13.12.4] synonym: "lactic oxidase activity" EXACT [EC:1.13.12.4] synonym: "lactic oxygenase activity" EXACT [EC:1.13.12.4] xref: EC:1.13.12.4 xref: GO:0050040 xref: MetaCyc:LACTATE-2-MONOOXYGENASE-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: CCO:F0007394 name: lactate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate = formate + acetaldehyde." [EC:4.1.2.36, MetaCyc:LACTATE-ALDOLASE-RXN] synonym: "(S)-lactate acetaldehyde-lyase (formate-forming)" EXACT [EC:4.1.2.36] synonym: "(S)-lactate acetaldehyde-lyase activity" EXACT [EC:4.1.2.36] synonym: "lactate synthase activity" EXACT [EC:4.1.2.36] xref: EC:4.1.2.36 xref: GO:0050041 xref: MetaCyc:LACTATE-ALDOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007395 name: lactate-malate transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + oxaloacetate = pyruvate + malate." [EC:1.1.99.7, MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN] synonym: "(S)-lactate:oxaloacetate oxidoreductase activity" EXACT [EC:1.1.99.7] synonym: "malate-lactate transhydrogenase activity" EXACT [EC:1.1.99.7] xref: EC:1.1.99.7 xref: GO:0050042 xref: MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007396 name: lactate racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate = (R)-lactate." [EC:5.1.2.1, MetaCyc:LACTATE-RACEMASE-RXN] synonym: "hydroxyacid racemase activity" EXACT [EC:5.1.2.1] synonym: "lactic acid racemase activity" EXACT [EC:5.1.2.1] synonym: "lacticoracemase activity" EXACT [EC:5.1.2.1] xref: EC:5.1.2.1 xref: GO:0050043 xref: MetaCyc:LACTATE-RACEMASE-RXN is_a: CCO:F0003419 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: CCO:F0007397 name: galactose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate." [EC:5.3.1.26, MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN] subset: gosubset_prok synonym: "D-galactose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.26] synonym: "D-galactose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.26] xref: EC:5.3.1.26 xref: GO:0050044 xref: MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0007398 name: laminaribiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.31, MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN] synonym: "3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.31] xref: EC:2.4.1.31 xref: GO:0050045 xref: MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0007399 name: lathosterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2." [EC:1.14.21.6, MetaCyc:LATHOSTEROL-OXIDASE-RXN] synonym: "5-DES" RELATED [EC:1.14.21.6] synonym: "5alpha-cholest-7-en-3beta-ol, NAD(P)H:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.21.6] synonym: "delta7-sterol 5-desaturase activity" EXACT [EC:1.14.21.6] synonym: "delta7-sterol delta5-dehydrogenase activity" EXACT [EC:1.14.21.6] synonym: "delta7-sterol-C5(6)-desaturase activity" EXACT [EC:1.14.21.6] synonym: "lathosterol 5-desaturase activity" EXACT [EC:1.14.21.6] xref: EC:1.14.21.6 xref: GO:0050046 xref: MetaCyc:LATHOSTEROL-OXIDASE-RXN is_a: CCO:F0006310 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: CCO:F0007400 name: leucine 2,3-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-alpha-leucine = (3R)-beta-leucine." [EC:5.4.3.7, MetaCyc:LEUCINE-2] synonym: "(2S)-alpha-leucine 2,3-aminomutase activity" EXACT [EC:5.4.3.7] xref: EC:5.4.3.7 xref: GO:0050047 xref: MetaCyc:LEUCINE-2 is_a: CCO:F0003430 ! intramolecular transferase activity, transferring amino groups [Term] id: CCO:F0007401 name: leucine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [EC:2.6.1.6, MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN] synonym: "L-leucine aminotransferase activity" EXACT [EC:2.6.1.6] synonym: "L-leucine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.6] synonym: "leucine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.6] synonym: "leucine aminotransferase activity" EXACT [] synonym: "leucine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.6] xref: EC:2.6.1.6 xref: GO:0050048 xref: MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007402 name: leucine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH." [EC:1.4.1.9, MetaCyc:LEUCINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "L-leucine dehydrogenase activity" EXACT [EC:1.4.1.9] synonym: "L-leucine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.9] synonym: "L-leucine:NAD+ oxidoreductase, deaminating" EXACT [EC:1.4.1.9] synonym: "LeuDH activity" EXACT [EC:1.4.1.9] xref: EC:1.4.1.9 xref: GO:0050049 xref: MetaCyc:LEUCINE-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007403 name: leucine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-leucine = CoA + N-acetyl-L-leucine." [EC:2.3.1.66, MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:L-leucine N-acetyltransferase activity" EXACT [EC:2.3.1.66] synonym: "leucine acetyltransferase activity" EXACT [EC:2.3.1.66] xref: EC:2.3.1.66 xref: GO:0050050 xref: MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0007404 name: leukotriene-B4 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN] synonym: "(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.30] synonym: "leucotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "leukotriene-B(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "leukotriene-B(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "leukotriene-B4 20-hydroxylase activity" EXACT [] synonym: "leukotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "LTB(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "LTB(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "LTB4 20-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "LTB4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] xref: EC:1.14.13.30 xref: GO:0050051 xref: MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007405 name: leukotriene-E4 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 = 20-hydroxy-leucotriene E4 + NADP+ + H2O." [EC:1.14.13.34, MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN] synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.34] synonym: "leukotriene-E(4) omega-hydroxylase activity" EXACT [EC:1.14.13.34] synonym: "leukotriene-E4 omega-hydroxylase activity" EXACT [EC:1.14.13.34] synonym: "leukotriene-E4 w-hydroxylase activity" EXACT [] xref: EC:1.14.13.34 xref: GO:0050052 xref: MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007406 name: levansucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)." [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN] subset: gosubset_prok synonym: "beta-2,6-fructan:D-glucose 1-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "beta-2,6-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose 6-fructosyl transferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose 6-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.10] xref: EC:2.4.1.10 xref: GO:0050053 xref: MetaCyc:LEVANSUCRASE-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0007407 name: lignostilbene alpha beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethene + O2 = 2 vanillin." [EC:1.13.11.43, MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN] synonym: "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)" EXACT [EC:1.13.11.43] synonym: "lignostilbene ab-dioxygenase activity" EXACT [] synonym: "lignostilbene alphabeta-dioxygenase activity" EXACT [EC:1.13.11.43] xref: EC:1.13.11.43 xref: GO:0050054 xref: MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007408 name: limonin-D-ring-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate." [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN] synonym: "limonin lactone hydrolase activity" EXACT [EC:3.1.1.36] synonym: "limonin-D-ring-lactone hydrolase activity" EXACT [EC:3.1.1.36] synonym: "limonoate-D-ring-lactone lactonohydrolase activity" EXACT [EC:3.1.1.36] xref: EC:3.1.1.36 xref: GO:0050055 xref: MetaCyc:LIMONIN-D-RING-LACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007409 name: linalool 8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,7-dimethylocta-1,6-dien-3-ol + donor-H2 + O2 = (E)-3,7-dimethylocta-1,6-dien-3,8-diol + acceptor + H2O." [EC:1.14.99.28, MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN] subset: gosubset_prok synonym: "3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.99.28] xref: EC:1.14.99.28 xref: GO:0050056 xref: MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007410 name: linamarin synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin." [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN] synonym: "UDP glucose ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "uridine diphosphoglucose-ketone glucosyltransferase activity" EXACT [EC:2.4.1.63] xref: EC:2.4.1.63 xref: GO:0050057 xref: MetaCyc:LINAMARIN-SYNTHASE-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0007411 name: linoleate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 9-cis,12-cis-octadecadienoate = 9-cis,11-trans-octadecadienoate." [EC:5.2.1.5, MetaCyc:LINOLEATE-ISOMERASE-RXN] synonym: "linoleate delta12-cis-delta11-trans-isomerase activity" EXACT [EC:5.2.1.5] synonym: "linoleic acid isomerase activity" EXACT [EC:5.2.1.5] xref: EC:5.2.1.5 xref: GO:0050058 xref: MetaCyc:LINOLEATE-ISOMERASE-RXN is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0007412 name: lombricine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine." [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN] synonym: "ATP:lombricine N-phosphotransferase activity" EXACT [EC:2.7.3.5] xref: EC:2.7.3.5 xref: GO:0050059 xref: MetaCyc:LOMBRICINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0007413 name: long-chain-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH." [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN] synonym: "fatty alcohol oxidoreductase activity" EXACT [EC:1.1.1.192] synonym: "long-chain alcohol dehydrogenase activity" EXACT [EC:1.1.1.192] synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.192] xref: EC:1.1.1.192 xref: GO:0050060 xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007414 name: long-chain-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+." [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN] synonym: "fatty aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] synonym: "long-chain aliphatic aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] synonym: "long-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] xref: EC:1.2.1.48 xref: GO:0050061 xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007415 name: long-chain-fatty-acyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN] subset: gosubset_prok synonym: "acyl coenzyme A reductase activity" EXACT [EC:1.2.1.50] synonym: "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)" EXACT [EC:1.2.1.50] xref: EC:1.2.1.50 xref: GO:0050062 xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007416 name: low-density-lipoprotein-receptor kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine." [EC:2.7.11.29, MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN] synonym: "[low-density lipoprotein receptor] kinase activity" EXACT [] synonym: "ATP:low-density-lipoprotein receptor-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29] synonym: "ATP:low-density-lipoprotein-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29] synonym: "LDL receptor kinase activity" EXACT [EC:2.7.11.29] synonym: "low-density lipoprotein receptor kinase activity" EXACT [EC:2.7.11.29] synonym: "low-density-lipoprotein kinase activity" BROAD [EC:2.7.11.29] synonym: "low-density-lipoprotein receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.29] synonym: "STK7" RELATED [EC:2.7.11.29] xref: EC:2.7.11.29 xref: GO:0050063 xref: MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0007417 name: luteolin 7-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate + luteolin = UDP + luteolin 7-O-beta-D-glucuronide." [EC:2.4.1.189, MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN] synonym: "LGT" RELATED [EC:2.4.1.189] synonym: "luteolin 7-O-glucoronosyltransferase activity" EXACT [] synonym: "UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] synonym: "UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] xref: EC:2.4.1.189 xref: GO:0050064 xref: MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0007418 name: lysine-pyruvate 6-transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + pyruvate = 2-aminoadipate 6-semialdehyde + L-alanine." [EC:2.6.1.71, MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN] synonym: "L-lysine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.71] synonym: "Lys-AT" RELATED [EC:2.6.1.71] synonym: "lysine--pyruvate 6-aminotransferase activity" EXACT [] synonym: "lysine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.71] xref: EC:2.6.1.71 xref: GO:0050065 xref: MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN xref: MetaCyc:PWY-5324 is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007419 name: lysine 2,3-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." [EC:5.4.3.2, MetaCyc:LYSINE-2] subset: gosubset_prok synonym: "L-lysine 2,3-aminomutase activity" EXACT [EC:5.4.3.2] xref: EC:5.4.3.2 xref: GO:0050066 xref: MetaCyc:LYSINE-2 is_a: CCO:F0003430 ! intramolecular transferase activity, transferring amino groups [Term] id: CCO:F0007420 name: lysine 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O." [EC:1.13.12.2, MetaCyc:LYSINE-2-MONOOXYGENASE-RXN] synonym: "L-lysine-2-monooxygenase activity" EXACT [EC:1.13.12.2] synonym: "L-lysine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.2] synonym: "lysine monooxygenase activity" EXACT [EC:1.13.12.2] synonym: "lysine oxygenase activity" EXACT [EC:1.13.12.2] xref: EC:1.13.12.2 xref: GO:0050067 xref: MetaCyc:LYSINE-2-MONOOXYGENASE-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: CCO:F0007421 name: lysine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + L-lysine = phosphate + L-homocitrulline." [EC:2.1.3.8, MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN] synonym: "carbamoyl-phosphate:L-lysine carbamoyltransferase activity" EXACT [EC:2.1.3.8] synonym: "lysine transcarbamylase activity" EXACT [EC:2.1.3.8] xref: EC:2.1.3.8 xref: GO:0050068 xref: MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN is_a: CCO:F0003319 ! carboxyl- or carbamoyltransferase activity [Term] id: CCO:F0007422 name: lysine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH." [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN] synonym: "L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)" EXACT [EC:1.4.1.15] xref: EC:1.4.1.15 xref: GO:0050069 xref: MetaCyc:LYSINE-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007423 name: lysolecithin acylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-lysolecithin = 3-lysolecithin." [EC:5.4.1.1, MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN] synonym: "lysolecithin 2,3-acylmutase activity" EXACT [EC:5.4.1.1] synonym: "lysolecithin migratase activity" RELATED [EC:5.4.1.1] xref: EC:5.4.1.1 xref: GO:0050070 xref: MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN is_a: CCO:F0003428 ! intramolecular transferase activity, transferring acyl groups [Term] id: CCO:F0007424 name: lysyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol." [EC:2.3.2.3, MetaCyc:LYSYLTRANSFERASE-RXN] subset: gosubset_prok synonym: "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity" EXACT [EC:2.3.2.3] synonym: "L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity" EXACT [EC:2.3.2.3] xref: EC:2.3.2.3 xref: GO:0050071 xref: MetaCyc:LYSYLTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0007425 name: m7G(5')pppN diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [EC:3.6.1.30, MetaCyc:M(7)G(5] synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [EC:3.6.1.30] synonym: "decapase activity" RELATED [EC:3.6.1.30] synonym: "M(7)G(5')pppN pyrophosphatase activity" EXACT [] synonym: "m7G(5')pppN pyrophosphatase activity" EXACT [EC:3.6.1.30] xref: EC:3.6.1.30 xref: GO:0050072 xref: MetaCyc:M(7)G(5 is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0007426 name: macrolide 2'-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oleandomycin = ADP + oleandomycin 2'-O-phosphate." [EC:2.7.1.136, MetaCyc:MACROLIDE-2] synonym: "ATP:macrolide 2'-O-phosphotransferase activity" EXACT [EC:2.7.1.136] xref: EC:2.7.1.136 xref: GO:0050073 xref: MetaCyc:MACROLIDE-2 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007427 name: malate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA." [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN] subset: gosubset_prok synonym: "malate thiokinase activity" RELATED [EC:6.2.1.9] synonym: "malate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.9] synonym: "malyl coenzyme A synthetase activity" EXACT [EC:6.2.1.9] synonym: "malyl-CoA synthetase activity" EXACT [EC:6.2.1.9] xref: EC:6.2.1.9 xref: GO:0050074 xref: MetaCyc:MALATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007428 name: maleate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-malate = maleate + H2O." [EC:4.2.1.31, MetaCyc:MALEATE-HYDRATASE-RXN] synonym: "(R)-malate hydro-lyase (maleate-forming)" EXACT [EC:4.2.1.31] synonym: "(R)-malate hydro-lyase activity" EXACT [EC:4.2.1.31] synonym: "D-malate hydro-lyase activity" EXACT [EC:4.2.1.31] synonym: "malease activity" EXACT [EC:4.2.1.31] xref: EC:4.2.1.31 xref: GO:0050075 xref: MetaCyc:MALEATE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007429 name: maleate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: maleate = fumarate." [EC:5.2.1.1, MetaCyc:MALEATE-ISOMERASE-RXN] subset: gosubset_prok synonym: "maleate cis-trans-isomerase activity" EXACT [EC:5.2.1.1] xref: EC:5.2.1.1 xref: GO:0050076 xref: MetaCyc:MALEATE-ISOMERASE-RXN is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0007430 name: maleylpyruvate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate." [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN] subset: gosubset_prok synonym: "3-maleylpyruvate cis-trans-isomerase activity" EXACT [EC:5.2.1.4] xref: EC:5.2.1.4 xref: GO:0050077 xref: MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0007431 name: malonate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA." [EC:2.8.3.3, MetaCyc:MALONATE-COA-TRANSFERASE-RXN] synonym: "acetyl-CoA:malonate CoA-transferase activity" EXACT [EC:2.8.3.3] synonym: "malonate coenzyme A-transferase activity" EXACT [EC:2.8.3.3] xref: EC:2.8.3.3 xref: GO:0050078 xref: MetaCyc:MALONATE-COA-TRANSFERASE-RXN is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0007432 name: acetylenecarboxylate hydratase activity, producing 3-oxopropanoate namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O." [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN] comment: Note that this function was formerly EC:4.2.1.71. synonym: "3-oxopropanoate hydro-lyase (propynoate-forming)" EXACT [EC:4.2.1.27] synonym: "3-oxopropanoate hydro-lyase activity" EXACT [EC:4.2.1.27] synonym: "acetylenecarboxylate hydratase activity" BROAD [] synonym: "acetylenecarboxylate hydratase activity, producing malonate-semialdehyde" EXACT [] synonym: "acetylenemonocarboxylate hydrase activity" EXACT [EC:4.2.1.27] synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] synonym: "acetylmonocarboxylic acid hydrase activity" EXACT [EC:4.2.1.27] synonym: "alkynoate hydratase activity" BROAD [] synonym: "malonate-semialdehyde dehydratase activity" EXACT [] xref: EC:4.2.1.27 xref: GO:0047607 xref: GO:0050079 xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007433 name: malonyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "malonyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.9] synonym: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.1.9] synonym: "malonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.9] xref: EC:4.1.1.9 xref: GO:0050080 xref: MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007434 name: maltose-6'-phosphate glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.122, MetaCyc:MALTOSE-6] subset: gosubset_prok synonym: "maltose-6'-phosphate 6-phosphoglucohydrolase activity" EXACT [EC:3.2.1.122] synonym: "phospho-alpha-glucosidase activity" EXACT [EC:3.2.1.122] xref: EC:3.2.1.122 xref: GO:0050081 xref: MetaCyc:MALTOSE-6 is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0007435 name: maltose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN] subset: gosubset_prok synonym: "maltose:phosphate 1-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.8] xref: EC:2.4.1.8 xref: GO:0050082 xref: MetaCyc:MALTOSE-PHOSPHORYLASE-RXN is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0007436 name: malyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate." [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN] synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.24] synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity" EXACT [EC:4.1.3.24] synonym: "malyl-coenzyme A lyase activity" EXACT [EC:4.1.3.24] xref: EC:4.1.3.24 xref: GO:0050083 xref: MetaCyc:MALYL-COA-LYASE-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0007437 name: mannitol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + phosphate." [EC:3.1.3.22, MetaCyc:MANNITOL-1-PHOSPHATASE-RXN] synonym: "D-mannitol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.22] synonym: "mannitol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.22] xref: EC:3.1.3.22 xref: GO:0050084 xref: MetaCyc:MANNITOL-1-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007438 name: mannitol 2-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + NADPH." [EC:1.1.1.138, MetaCyc:MANNITOL-2-DEHYDROGENASE-(NADP+)-RXN] synonym: "D-mannitol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.138] synonym: "NADP-dependent mannitol dehydrogenase activity" EXACT [EC:1.1.1.138] xref: EC:1.1.1.138 xref: GO:0050085 xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007439 name: mannitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH." [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "D-mannitol dehydrogenase activity" EXACT [EC:1.1.1.67] synonym: "D-mannitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.67] xref: EC:1.1.1.67 xref: GO:0050086 xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007440 name: mannitol dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c." [EC:1.1.2.2, MetaCyc:MANNITOL-DEHYDROGENASE-(CYTOCHROME)-RXN] synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.2] synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2] xref: EC:1.1.2.2 xref: GO:0050087 xref: MetaCyc:MANNITOL-DEHYDROGENASE-(CYTOCHROME)-RXN is_a: CCO:F0003456 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: CCO:F0007441 name: mannose-6-phosphate 6-reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + NADPH." [EC:1.1.1.224, MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN] synonym: "6-phosphomannose reductase activity" EXACT [EC:1.1.1.224] synonym: "D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.224] synonym: "mannose-6-phosphate reductase activity" EXACT [EC:1.1.1.224] synonym: "NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity" EXACT [EC:1.1.1.224] synonym: "NADPH-dependent M6P reductase activity" EXACT [EC:1.1.1.224] synonym: "NADPH-dependent mannose 6-phosphate reductase activity" EXACT [EC:1.1.1.224] synonym: "NADPH-mannose-6-P reductase activity" EXACT [EC:1.1.1.224] xref: EC:1.1.1.224 xref: GO:0050088 xref: MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007442 name: mannose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannose = D-fructose." [EC:5.3.1.7, MetaCyc:MANNOSE-ISOMERASE-RXN] synonym: "D-mannose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.7] synonym: "D-mannose isomerase activity" EXACT [EC:5.3.1.7] synonym: "D-mannose ketol-isomerase activity" EXACT [EC:5.3.1.7] xref: EC:5.3.1.7 xref: GO:0050089 xref: MetaCyc:MANNOSE-ISOMERASE-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0007443 name: mannuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+." [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN] synonym: "D-mannonate:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.131] synonym: "D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))" EXACT [EC:1.1.1.131] synonym: "mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity" EXACT [EC:1.1.1.131] synonym: "mannonate dehydrogenase (NAD(P)+)" EXACT [EC:1.1.1.131] synonym: "mannonate dehydrogenase activity" EXACT [EC:1.1.1.131] xref: EC:1.1.1.131 xref: GO:0050090 xref: MetaCyc:MANNURONATE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007444 name: melilotate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O." [EC:1.14.13.4, MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN] synonym: "2-hydroxyphenylpropionate hydroxylase activity" EXACT [EC:1.14.13.4] synonym: "2-hydroxyphenylpropionic hydroxylase activity" EXACT [EC:1.14.13.4] synonym: "3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.4] synonym: "melilotate hydroxylase activity" EXACT [] synonym: "melilotic hydroxylase activity" EXACT [EC:1.14.13.4] xref: EC:1.14.13.4 xref: GO:0050091 xref: MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007445 name: meso-tartrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: meso-tartrate + NAD+ = dihydroxyfumarate + NADH." [EC:1.3.1.7, MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN] synonym: "meso-tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.7] xref: EC:1.3.1.7 xref: GO:0050092 xref: MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007446 name: methanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: methanol + NAD+ = formaldehyde + NADH." [EC:1.1.1.244, MetaCyc:METHANOL-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "methanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.244] xref: EC:1.1.1.244 xref: GO:0050093 xref: MetaCyc:METHANOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007447 name: methionine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine." [EC:2.6.1.73, MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN] synonym: "L-methionine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73] synonym: "methionine-glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73] synonym: "MGAT activity" EXACT [EC:2.6.1.73] xref: EC:2.6.1.73 xref: GO:0050094 xref: MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007448 name: methionine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine = 3-methylthiopropanamine + CO2." [EC:4.1.1.57, MetaCyc:METHIONINE-DECARBOXYLASE-RXN] synonym: "L-methionine carboxy-lyase (3-methylthiopropanamine-forming)" EXACT [EC:4.1.1.57] synonym: "L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.57] synonym: "L-methionine decarboxylase activity" EXACT [EC:4.1.1.57] xref: EC:4.1.1.57 xref: GO:0050095 xref: MetaCyc:METHIONINE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007449 name: methylaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-threo-3-methylaspartate = mesaconate + NH3." [EC:4.3.1.2, MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN] subset: gosubset_prok synonym: "3-methylaspartase activity" EXACT [EC:4.3.1.2] synonym: "beta-methylaspartase activity" EXACT [EC:4.3.1.2] synonym: "L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)" EXACT [EC:4.3.1.2] synonym: "L-threo-3-methylaspartate ammonia-lyase activity" EXACT [EC:4.3.1.2] xref: EC:4.3.1.2 xref: GO:0050096 xref: MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0007450 name: methylaspartate mutase activity namespace: molecular_function def: "Catalysis of the reaction: L-threo-3-methylaspartate = L-glutamate." [EC:5.4.99.1, MetaCyc:METHYLASPARTATE-MUTASE-RXN] subset: gosubset_prok synonym: "b-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1] synonym: "beta-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1] synonym: "glutamate isomerase activity" EXACT [EC:5.4.99.1] synonym: "glutamate mutase activity" EXACT [EC:5.4.99.1] synonym: "glutamic acid isomerase activity" EXACT [EC:5.4.99.1] synonym: "glutamic acid mutase activity" EXACT [EC:5.4.99.1] synonym: "glutamic isomerase activity" EXACT [EC:5.4.99.1] synonym: "glutamic mutase activity" EXACT [EC:5.4.99.1] synonym: "L-threo-3-methylaspartate carboxy-aminomethylmutase activity" EXACT [EC:5.4.99.1] synonym: "methylaspartic acid mutase activity" EXACT [EC:5.4.99.1] xref: EC:5.4.99.1 xref: GO:0050097 xref: MetaCyc:METHYLASPARTATE-MUTASE-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0007451 name: methylguanidinase activity namespace: molecular_function def: "Catalysis of the reaction: methylguanidine + H2O = methylamine + urea." [EC:3.5.3.16, MetaCyc:METHYLGUANIDINASE-RXN] synonym: "methylguanidine amidinohydrolase activity" EXACT [EC:3.5.3.16] synonym: "methylguanidine hydrolase activity" EXACT [EC:3.5.3.16] xref: EC:3.5.3.16 xref: GO:0050098 xref: MetaCyc:METHYLGUANIDINASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0007452 name: methylglutamate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor." [EC:1.5.99.5, MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN] synonym: "N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.5] synonym: "N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.5] synonym: "N-methylglutamate dehydrogenase activity" EXACT [EC:1.5.99.5] xref: EC:1.5.99.5 xref: GO:0050099 xref: MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0007453 name: methylitaconate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: methylitaconate = dimethylmaleate." [EC:5.3.3.6, MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN] synonym: "methylitaconate D-isomerase activity" EXACT [] synonym: "methylitaconate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.6] synonym: "methylitaconate isomerase activity" EXACT [EC:5.3.3.6] xref: EC:5.3.3.6 xref: GO:0050100 xref: MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0007454 name: mimosinase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine." [EC:3.5.1.61, MetaCyc:MIMOSINASE-RXN] synonym: "mimosine amidohydrolase activity" EXACT [EC:3.5.1.61] xref: EC:3.5.1.61 xref: GO:0050101 xref: MetaCyc:MIMOSINASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007455 name: cellodextrin phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN] subset: gosubset_prok synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.49] synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.49] xref: EC:2.4.1.49 xref: GO:0050102 xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0007456 name: dextrin dextranase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)." [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN] synonym: "1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.2] synonym: "dextran dextrinase activity" EXACT [EC:2.4.1.2] synonym: "dextrin 6-glucosyltransferase activity" EXACT [EC:2.4.1.2] xref: EC:2.4.1.2 xref: GO:0050103 xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0007457 name: L-gulonate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH." [EC:1.1.1.45, MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "L-3-aldonate dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-3-aldonic dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-3-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-beta-hydroxy-acid-NAD-oxidoreductase activity" EXACT [EC:1.1.1.45] synonym: "L-beta-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-gulonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.45] synonym: "L-gulonic acid dehydrogenase activity" EXACT [EC:1.1.1.45] xref: EC:1.1.1.45 xref: GO:0050104 xref: MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007458 name: L-gulonolactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2." [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN] subset: gosubset_prok synonym: "GLO activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-gamma-lactone oxidase activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-gamma-lactone:O2 oxidoreductase activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-gamma-lactone:oxidoreductase activity" EXACT [EC:1.1.3.8] xref: EC:1.1.3.8 xref: GO:0050105 xref: MetaCyc:L-GULONOLACTONE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007459 name: monomethyl-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: monomethyl sulfate + H2O = methanol + SO4(2-) (sulfate)." [EC:3.1.6.16, MetaCyc:MONOMETHYL-SULFATASE-RXN] synonym: "monomethyl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.16] synonym: "monomethyl-sulphatase activity" EXACT [] xref: EC:3.1.6.16 xref: GO:0050106 xref: MetaCyc:MONOMETHYL-SULFATASE-RXN is_a: CCO:F0001945 ! sulfuric ester hydrolase activity [Term] id: CCO:F0007460 name: monoterpenol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester." [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:monoterpenol O-acetyltransferase activity" EXACT [EC:2.3.1.69] synonym: "menthol transacetylase activity" NARROW [EC:2.3.1.69] xref: EC:2.3.1.69 xref: GO:0050107 xref: MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0007461 name: monoterpenyl-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate." [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN] synonym: "bornyl diphosphate hydrolase activity" EXACT [EC:3.1.7.3] synonym: "bornyl pyrophosphate hydrolase activity" EXACT [EC:3.1.7.3] synonym: "monoterpenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.3] synonym: "monoterpenyl-pyrophosphatase activity" EXACT [] xref: EC:3.1.7.3 xref: GO:0050108 xref: MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN is_a: CCO:F0003364 ! diphosphoric monoester hydrolase activity [Term] id: CCO:F0007462 name: morphine 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+." [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "morphine:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.218] synonym: "naloxone reductase activity" EXACT [EC:1.1.1.218] synonym: "reductase, naloxone" EXACT [EC:1.1.1.218] xref: EC:1.1.1.218 xref: GO:0050109 xref: MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007463 name: mucinaminylserine mucinaminidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine." [EC:3.2.1.110, MetaCyc:MUCINAMINYLSERINE-MUCINAMINIDASE-RXN] synonym: "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity" EXACT [EC:3.2.1.110] synonym: "endo-alpha-N-acetyl-D-galactosaminidase activity" EXACT [EC:3.2.1.110] synonym: "endo-alpha-N-acetylgalactosaminidase" BROAD [EC:3.2.1.110] xref: EC:3.2.1.110 xref: GO:0050110 xref: MetaCyc:MUCINAMINYLSERINE-MUCINAMINIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007464 name: mycocerosate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + n methylmalonyl-CoA + 2n NADPH + 2n H+ = multi-methyl-branched acyl-CoA + n CoA + n CO2 + 2n NADP+." [EC:2.3.1.111, MetaCyc:MYCOCEROSATE-SYNTHASE-RXN] synonym: "acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)" EXACT [EC:2.3.1.111] synonym: "mycocerosic acid synthase activity" EXACT [EC:2.3.1.111] xref: EC:2.3.1.111 xref: GO:0050111 xref: MetaCyc:MYCOCEROSATE-SYNTHASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007465 name: inositol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH." [EC:1.1.1.18, MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "myo-inositol 2-dehydrogenase activity" EXACT [] xref: EC:1.1.1.18 xref: GO:0050112 xref: MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN is_a: CCO:F0000511 ! aldo-keto reductase activity [Term] id: CCO:F0007466 name: inositol oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O." [EC:1.13.99.1, MetaCyc:MYO-INOSITOL-OXYGENASE-RXN] synonym: "meso-inositol oxygenase activity" EXACT [EC:1.13.99.1] synonym: "MOO activity" EXACT [EC:1.13.99.1] synonym: "myo-inositol oxygenase activity" EXACT [] synonym: "myo-inositol:oxygen oxidoreductase activity" EXACT [EC:1.13.99.1] xref: EC:1.13.99.1 xref: GO:0050113 xref: MetaCyc:MYO-INOSITOL-OXYGENASE-RXN is_a: CCO:F0003285 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: CCO:F0007467 name: myo-inosose-2 dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O." [EC:4.2.1.44, MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN] synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)" EXACT [EC:4.2.1.44] synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity" EXACT [EC:4.2.1.44] synonym: "inosose 2,3-dehydratase activity" EXACT [EC:4.2.1.44] synonym: "ketoinositol dehydratase activity" EXACT [EC:4.2.1.44] xref: EC:4.2.1.44 xref: GO:0050114 xref: MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007468 name: myosin-light-chain-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate." [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN] synonym: "[Myosin light-chain]-phosphatase activity" EXACT [] synonym: "myosin light chain kinase phosphatase activity" EXACT [EC:3.1.3.53] synonym: "myosin light-chain kinase phosphatase activity" RELATED [EC:3.1.3.53] synonym: "myosin-light-chain phosphatase activity" EXACT [EC:3.1.3.53] synonym: "myosin-light-chain-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.53] synonym: "protein phosphatase 2A" RELATED [EC:3.1.3.53] xref: EC:3.1.3.53 xref: GO:0050115 xref: MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007469 name: N,N-dimethylformamidase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate." [EC:3.5.1.56, MetaCyc:N] synonym: "dimethylformamidase activity" EXACT [EC:3.5.1.56] synonym: "DMFase activity" EXACT [EC:3.5.1.56] synonym: "N,N-dimethylformamide amidohydrolase activity" EXACT [EC:3.5.1.56] xref: EC:3.5.1.56 xref: GO:0050116 xref: MetaCyc:N is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007470 name: N-acetyl-beta-alanine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-alanine + H2O = acetate + beta-alanine." [EC:3.5.1.21, MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN] synonym: "N-acetyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.21] xref: EC:3.5.1.21 xref: GO:0050117 xref: MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0007471 name: N-acetyldiaminopimelate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-LL2,6-diaminoheptanedioate + H2O = acetate + LL2,6-diaminoheptanedioate." [EC:3.5.1.47, MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN] subset: gosubset_prok synonym: "6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47] synonym: "N-acetyl-L-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.47] synonym: "N-acetyl-LL-diaminopimelate deacylase activity" EXACT [EC:3.5.1.47] synonym: "N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47] xref: EC:3.5.1.47 xref: GO:0050118 xref: MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0007472 name: N-acetylglucosamine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate." [EC:3.5.1.33, MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN] synonym: "acetylaminodeoxyglucose acetylhydrolase activity" EXACT [EC:3.5.1.33] synonym: "N-acetyl-D-glucosamine amidohydrolase activity" EXACT [EC:3.5.1.33] synonym: "N-acetyl-D-glucosaminyl N-deacetylase activity" EXACT [EC:3.5.1.33] xref: EC:3.5.1.33 xref: GO:0050119 xref: MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: CCO:F0004136 ! deacetylase activity [Term] id: CCO:F0007473 name: N-acetylhexosamine 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + N-acetyl-D-glucosamine = NADH + N-acetyl-D-glucosaminate." [EC:1.1.1.240, MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN] synonym: "N-acetyl-D-hexosamine dehydrogenase activity" EXACT [EC:1.1.1.240] synonym: "N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.240] synonym: "N-acetylhexosamine dehydrogenase activity" EXACT [EC:1.1.1.240] xref: EC:1.1.1.240 xref: GO:0050120 xref: MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007474 name: N-acylglucosamine 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN] subset: gosubset_prok synonym: "acylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "GlcNAc 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "N-acetylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "N-acyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] xref: EC:5.1.3.8 xref: GO:0050121 xref: MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007475 name: N-acylhexosamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + O2 + N-acetyl-D-glucosamine = H2O2 + N-acetyl-D-glucosaminate." [EC:1.1.3.29, MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN] synonym: "N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29] synonym: "N-acyl-D-hexosamine oxidase activity" EXACT [EC:1.1.3.29] synonym: "N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29] xref: EC:1.1.3.29 xref: GO:0050122 xref: MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007476 name: N-acylmannosamine 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + NADH." [EC:1.1.1.233, MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "N-acetyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] synonym: "N-acyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] synonym: "N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.233] synonym: "N-acylmannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] xref: EC:1.1.1.233 xref: GO:0050123 xref: MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007477 name: N-acylneuraminate-9-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN] subset: gosubset_prok synonym: "acylneuraminate 9-phosphatase activity" EXACT [EC:3.1.3.29] synonym: "N-acylneuraminate-9-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.29] synonym: "N-acylneuraminic (sialic) acid 9-phosphatase activity" EXACT [EC:3.1.3.29] synonym: "N-acylneuraminic acid 9-phosphate phosphatase activity" EXACT [EC:3.1.3.29] xref: EC:3.1.3.29 xref: GO:0050124 xref: MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007478 name: N-benzyloxycarbonylglycine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O = benzyl alcohol + CO2 + glycine." [EC:3.5.1.58, MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN] synonym: "benzyloxycarbonylglycine hydrolase activity" EXACT [EC:3.5.1.58] synonym: "N-benzyloxycarbonylglycine urethanehydrolase activity" EXACT [EC:3.5.1.58] synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity" EXACT [EC:3.5.1.58] synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase I" RELATED [EC:3.5.1.58] synonym: "nalpha-carbobenzoxyamino acid amidohydrolase activity" EXACT [EC:3.5.1.58] xref: EC:3.5.1.58 xref: GO:0050125 xref: MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007479 name: N-carbamoylputrescine amidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-carbamoylputrescine = NH3 + CO2 + putrescine." [EC:3.5.1.53, MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN] synonym: "carbamoylputrescine hydrolase activity" EXACT [EC:3.5.1.53] synonym: "N-carbamoylputrescine amidohydrolase activity" EXACT [EC:3.5.1.53] synonym: "NCP" RELATED [EC:3.5.1.53] xref: EC:3.5.1.53 xref: GO:0050126 xref: MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007480 name: N-carbamoylsarcosine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3." [EC:3.5.1.59, MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN] subset: gosubset_prok synonym: "carbamoylsarcosine amidase activity" EXACT [EC:3.5.1.59] synonym: "CSHase activity" EXACT [EC:3.5.1.59] synonym: "N-carbamoylsarcosine amidohydrolase activity" EXACT [EC:3.5.1.59] xref: EC:3.5.1.59 xref: GO:0050127 xref: MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007481 name: N-feruloylglycine deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine." [EC:3.5.1.71, MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN] synonym: "N-feruloylglycine amidohydrolase activity" EXACT [EC:3.5.1.71] synonym: "N-feruloylglycine hydrolase activity" EXACT [EC:3.5.1.71] xref: EC:3.5.1.71 xref: GO:0050128 xref: MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007482 name: N-formylglutamate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-glutamate + H2O = formate + L-glutamate." [EC:3.5.1.68, MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN] subset: gosubset_prok synonym: "beta-citryl-L-glutamate amidase activity" EXACT [EC:3.5.1.68] synonym: "beta-citryl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68] synonym: "beta-citryl-L-glutamate hydrolase activity" EXACT [EC:3.5.1.68] synonym: "beta-citryl-L-glutamate-hydrolyzing enzyme" RELATED [EC:3.5.1.68] synonym: "beta-citrylglutamate amidase activity" EXACT [EC:3.5.1.68] synonym: "formylglutamate deformylase activity" EXACT [EC:3.5.1.68] synonym: "N-formyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68] synonym: "N-formylglutamate hydrolase activity" EXACT [EC:3.5.1.68] xref: EC:3.5.1.68 xref: GO:0050129 xref: MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007483 name: N-methyl-2-oxoglutaramate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine." [EC:3.5.1.36, MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN] synonym: "5-hydroxy-N-methylpyroglutamate synthase activity" EXACT [EC:3.5.1.36] synonym: "N-methyl-2-oxoglutaramate methylamidohydrolase activity" EXACT [EC:3.5.1.36] xref: EC:3.5.1.36 xref: GO:0050130 xref: MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007484 name: N-methyl-L-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2." [EC:1.5.3.2, MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN] synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.2] synonym: "N-methylamino acid oxidase activity" EXACT [EC:1.5.3.2] xref: EC:1.5.3.2 xref: GO:0050131 xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0007485 name: N-methylalanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = pyruvate + methylamine + NADPH." [EC:1.4.1.17, MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN] synonym: "N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)" EXACT [EC:1.4.1.17] xref: EC:1.4.1.17 xref: GO:0050132 xref: MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007486 name: N6-hydroxylysine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + N6-hydroxy-L-lysine = CoA + N6-acetyl-N6-hydroxy-L-lysine." [EC:2.3.1.102, MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102] synonym: "acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102] synonym: "N(6)-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102] synonym: "N6-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102] synonym: "N6-hydroxylysine:acetyl CoA N6-transacetylase activity" EXACT [EC:2.3.1.102] xref: EC:2.3.1.102 xref: GO:0050133 xref: MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0007487 name: N6-methyl-lysine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N6-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2." [EC:1.5.3.4, MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN] synonym: "6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4] synonym: "epsilon-alkyl-L-lysine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.4] synonym: "epsilon-alkyllysinase activity" EXACT [EC:1.5.3.4] synonym: "epsilon-N-methyllysine demethylase activity" EXACT [EC:1.5.3.4] synonym: "N(6)-methyllysine oxidase activity" EXACT [EC:1.5.3.4] synonym: "N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4] synonym: "N6-methyllysine oxidase activity" EXACT [EC:1.5.3.4] xref: EC:1.5.3.4 xref: GO:0050134 xref: MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0007488 name: NAD(P)+ nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + H2O = ADPribose(P) + nicotinamide." [EC:3.2.2.6, MetaCyc:NAD(P)(+)-NUCLEOSIDASE-RXN] synonym: "NAD(P) nucleosidase activity" EXACT [] synonym: "NAD(P)(+) nucleosidase activity" EXACT [] synonym: "NAD(P)+ glycohydrolase activity" EXACT [EC:3.2.2.6] synonym: "NAD(P)ase activity" EXACT [EC:3.2.2.6] synonym: "nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity" EXACT [EC:3.2.2.6] synonym: "nicotinamide adenine dinucleotide (phosphate) nucleosidase activity" EXACT [EC:3.2.2.6] synonym: "triphosphopyridine nucleotidase activity" EXACT [EC:3.2.2.6] xref: EC:3.2.2.6 xref: GO:0050135 xref: MetaCyc:NAD(P)(+)-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0007489 name: NADH dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.99.5, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-(QUINONE)-RXN] subset: gosubset_prok synonym: "D-diaphorase activity" EXACT [EC:1.6.99.5] synonym: "DPNH-menadione reductase activity" EXACT [EC:1.6.99.5] synonym: "NADH-quinone oxidoreductase activity" EXACT [EC:1.6.99.5] synonym: "NADH:(quinone-acceptor) oxidoreductase activity" EXACT [EC:1.6.99.5] synonym: "reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity" EXACT [EC:1.6.99.5] xref: EC:1.6.99.5 xref: GO:0050136 xref: MetaCyc:NADH-DEHYDROGENASE-(QUINONE)-RXN is_a: CCO:F0000447 ! NADH dehydrogenase activity is_a: CCO:F0003253 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: CCO:F0007490 name: NADPH peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H2O2 = NADP+ + 2 H2O." [EC:1.11.1.2, MetaCyc:NADPH-PEROXIDASE-RXN] synonym: "NADP peroxidase activity" EXACT [EC:1.11.1.2] synonym: "NADPH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.2] synonym: "nicotinamide adenine dinucleotide phosphate peroxidase activity" EXACT [EC:1.11.1.2] synonym: "TPN peroxidase activity" EXACT [EC:1.11.1.2] synonym: "TPNH peroxidase activity" EXACT [EC:1.11.1.2] synonym: "triphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.2] xref: EC:1.11.1.2 xref: GO:0050137 xref: MetaCyc:NADPH-PEROXIDASE-RXN is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0007491 name: nicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinate + H2O + NADP+ = 6-hydroxynicotinate + NADPH." [EC:1.17.1.5, MetaCyc:NICOTINATE-DEHYDROGENASE-RXN] synonym: "nicotinate hydroxylase activity" EXACT [EC:1.17.1.5] synonym: "nicotinate:NADP+ 6-oxidoreductase (hydroxylating)" EXACT [EC:1.17.1.5] synonym: "nicotinic acid hydroxylase activity" EXACT [EC:1.17.1.5] xref: EC:1.17.1.5 xref: GO:0050138 xref: MetaCyc:NICOTINATE-DEHYDROGENASE-RXN is_a: CCO:F0003308 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: CCO:F0007492 name: nicotinate glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + nicotinate = UDP + N-glucosylnicotinate." [EC:2.4.1.196, MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP-glucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] synonym: "UDP-glucose:nicotinic acid-N-glucosyltransferase activity" EXACT [EC:2.4.1.196] synonym: "UDPglucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] synonym: "uridine diphosphoglucose-nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] xref: EC:2.4.1.196 xref: GO:0050139 xref: MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007493 name: nitrate reductase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: ferrocytochrome + NO3- (nitrate) = ferricytochrome + NO2- (nitrite)." [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-(CYTOCHROME)-RXN] synonym: "benzyl viologen-nitrate reductase activity" EXACT [EC:1.9.6.1] synonym: "ferrocytochrome:nitrate oxidoreductase activity" EXACT [EC:1.9.6.1] xref: EC:1.9.6.1 xref: GO:0050140 xref: MetaCyc:NITRATE-REDUCTASE-(CYTOCHROME)-RXN is_a: CCO:F0003269 ! oxidoreductase activity, acting on heme group of donors, nitrogenous group as acceptor [Term] id: CCO:F0007494 name: nitroethane oxidase activity namespace: molecular_function def: "Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + NO2(-) (nitrite) + H2O2." [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN] synonym: "NAO activity" EXACT [EC:1.7.3.1] synonym: "nitroalkane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1] synonym: "Nitroethane oxidase activity" EXACT [EC:1.7.3.1] synonym: "nitroethane reductase activity" EXACT [EC:1.7.3.1] synonym: "nitroethane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1] xref: EC:1.7.3.1 xref: GO:0050141 xref: MetaCyc:NITROETHANE-OXIDASE-RXN is_a: CCO:F0003258 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: CCO:F0007495 name: nitrogenase (flavodoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate." [EC:1.19.6.1, MetaCyc:NITROGENASE-(FLAVODOXIN)-RXN] subset: gosubset_prok synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" EXACT [EC:1.19.6.1] xref: EC:1.19.6.1 xref: GO:0050142 xref: MetaCyc:NITROGENASE-(FLAVODOXIN)-RXN is_a: CCO:F0003315 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor [Term] id: CCO:F0007496 name: nocardicin-A epimerase activity namespace: molecular_function def: "Catalysis of the reaction: isonocardicin A = nocardicin A." [EC:5.1.1.14, MetaCyc:NOCARDICIN-A-EPIMERASE-RXN] synonym: "isonocardicin A epimerase activity" EXACT [EC:5.1.1.14] xref: EC:5.1.1.14 xref: GO:0050143 xref: MetaCyc:NOCARDICIN-A-EPIMERASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0007497 name: nucleoside deoxyribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1." [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN] subset: gosubset_prok synonym: "deoxyribose transferase activity" EXACT [EC:2.4.2.6] synonym: "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)" RELATED [EC:2.4.2.6] synonym: "nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]" RELATED [EC:2.4.2.6] synonym: "nucleoside trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6] synonym: "nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.6] synonym: "purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity" EXACT [EC:2.4.2.6] synonym: "trans-deoxyribosylase activity" EXACT [EC:2.4.2.6] synonym: "trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6] synonym: "trans-N-glycosidase activity" EXACT [EC:2.4.2.6] xref: EC:2.4.2.6 xref: GO:0050144 xref: MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0007498 name: nucleoside phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate." [EC:2.7.4.4, MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN] synonym: "ATP:nucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.4] synonym: "NMP-kinase activity" EXACT [EC:2.7.4.4] synonym: "nucleoside-phosphate kinase activity" EXACT [] xref: EC:2.7.4.4 xref: GO:0050145 xref: MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor is_a: CCO:F0004128 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: CCO:F0007499 name: nucleoside phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate." [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN] synonym: "nonspecific nucleoside phosphotransferase activity" EXACT [EC:2.7.1.77] synonym: "nucleotide:2'-nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] synonym: "nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] xref: EC:2.7.1.77 xref: GO:0050146 xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004128 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: CCO:F0007500 name: nucleoside ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1." [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN] synonym: "nucleoside N-ribosyltransferase activity" EXACT [EC:2.4.2.5] synonym: "nucleoside:purine(pyrimidine) D-ribosyltransferase activity" EXACT [EC:2.4.2.5] xref: EC:2.4.2.5 xref: GO:0050147 xref: MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0007501 name: nucleotide diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate." [EC:2.7.6.4, MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN] synonym: "ATP nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4] synonym: "ATP:nucleoside-5'-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.4] synonym: "ATP:nucleotide pyrophosphotransferase activity" EXACT [EC:2.7.6.4] synonym: "nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4] synonym: "nucleotide pyrophosphokinase activity" EXACT [] xref: EC:2.7.6.4 xref: GO:0050148 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003350 ! diphosphotransferase activity [Term] id: CCO:F0007502 name: o-aminophenol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O." [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN] synonym: "2-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4] synonym: "2-aminophenol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.4] synonym: "GriF" RELATED [EC:1.10.3.4] synonym: "isophenoxazine synthase activity" EXACT [EC:1.10.3.4] synonym: "o-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4] xref: EC:1.10.3.4 xref: GO:0050149 xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN is_a: CCO:F0003273 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: CCO:F0007503 name: o-pyrocatechuate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate = catechol + CO2." [EC:4.1.1.46, MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN] synonym: "2,3-DHBA decarboxylase activity" EXACT [EC:4.1.1.46] synonym: "2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.46] synonym: "2,3-dihydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.46] synonym: "2,3-dihydroxybenzoic acid decarboxylase activity" EXACT [EC:4.1.1.46] xref: EC:4.1.1.46 xref: GO:0050150 xref: MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007504 name: oleate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-10-hydroxystearate = oleate + H2O." [EC:4.2.1.53, MetaCyc:OLEATE-HYDRATASE-RXN] synonym: "(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)" EXACT [EC:4.2.1.53] synonym: "(R)-10-hydroxystearate 10-hydro-lyase activity" EXACT [EC:4.2.1.53] xref: EC:4.2.1.53 xref: GO:0050151 xref: MetaCyc:OLEATE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007505 name: omega-amidase activity namespace: molecular_function def: "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN] synonym: "alpha-keto acid-omega-amidase activity" EXACT [EC:3.5.1.3] synonym: "omega-amidodicarboxylate amidohydrolase activity" EXACT [EC:3.5.1.3] synonym: "w-amidase activity" EXACT [] xref: EC:3.5.1.3 xref: GO:0050152 xref: MetaCyc:OMEGA-AMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007506 name: omega-hydroxydecanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + NADH." [EC:1.1.1.66, MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN] synonym: "10-hydroxydecanoate:NAD+ 10-oxidoreductase activity" EXACT [EC:1.1.1.66] synonym: "w-hydroxydecanoate dehydrogenase activity" EXACT [] xref: EC:1.1.1.66 xref: GO:0050153 xref: MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007507 name: opheline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = ADP + N'-phosphoguanidinoethyl methylphosphate." [EC:2.7.3.7, MetaCyc:OPHELINE-KINASE-RXN] synonym: "ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity" EXACT [EC:2.7.3.7] xref: EC:2.7.3.7 xref: GO:0050154 xref: MetaCyc:OPHELINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0007508 name: ornithine(lysine) transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [EC:2.6.1.68, MetaCyc:ORNITHINE(LYSINE)-AMINOTRANSFERASE-RXN] synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68] synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68] synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.68] synonym: "ornithine(lysine) aminotransferase activity" EXACT [] xref: EC:2.6.1.68 xref: GO:0050155 xref: MetaCyc:ORNITHINE(LYSINE)-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007509 name: ornithine N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 benzoyl-CoA + L-ornithine = 2 CoA + N2,N5-dibenzoyl-L-ornithine." [EC:2.3.1.127, MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN] synonym: "benzoyl-CoA:L-ornithine N-benzoyltransferase activity" EXACT [EC:2.3.1.127] synonym: "ornithine N-acyltransferase activity" EXACT [EC:2.3.1.127] xref: EC:2.3.1.127 xref: GO:0050156 xref: MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007510 name: ornithine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = D-ornithine." [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN] subset: gosubset_prok xref: EC:5.1.1.12 xref: GO:0050157 xref: MetaCyc:ORNITHINE-RACEMASE-RXN is_a: CCO:F0003418 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: CCO:F0007511 name: orotate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + NADP+ = orotate + NADPH." [EC:1.3.1.15, MetaCyc:OROTATE-REDUCTASE-(NADPH)-RXN] synonym: "(S)-dihydroorotate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.15] synonym: "dihydro-orotic dehydrogenase activity" EXACT [EC:1.3.1.15] synonym: "L-5,6-dihydro-orotate:NAD oxidoreductase activity" EXACT [EC:1.3.1.15] synonym: "orotate reductase activity" EXACT [EC:1.3.1.15] xref: EC:1.3.1.15 xref: GO:0050158 xref: MetaCyc:OROTATE-REDUCTASE-(NADPH)-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007512 name: orsellinate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-6-methylbenzoate = orcinol + CO2." [EC:4.1.1.58, MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN] synonym: "orsellinate carboxy-lyase (orcinol-forming)" EXACT [EC:4.1.1.58] synonym: "orsellinate carboxy-lyase activity" EXACT [EC:4.1.1.58] xref: EC:4.1.1.58 xref: GO:0050159 xref: MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007513 name: orsellinate-depside hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: orsellinate depside + H2O = 2 orsellinate." [EC:3.1.1.40, MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN] synonym: "lecanorate hydrolase activity" EXACT [EC:3.1.1.40] xref: EC:3.1.1.40 xref: GO:0050160 xref: MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007514 name: oxalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + oxalate = succinate + oxalyl-CoA." [EC:2.8.3.2, MetaCyc:OXALATE-COA-TRANSFERASE-RXN] synonym: "oxalate coenzyme A-transferase activity" EXACT [EC:2.8.3.2] synonym: "succinyl-beta-ketoacyl-CoA transferase activity" EXACT [EC:2.8.3.2] synonym: "succinyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.2] xref: EC:2.8.3.2 xref: GO:0050161 xref: MetaCyc:OXALATE-COA-TRANSFERASE-RXN is_a: CCO:F0001877 ! CoA-transferase activity [Term] id: CCO:F0007515 name: oxalate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: oxalate + O2 = 2 CO2 + H2O2." [EC:1.2.3.4, MetaCyc:OXALATE-OXIDASE-RXN] synonym: "aero-oxalo dehydrogenase activity" EXACT [EC:1.2.3.4] synonym: "oxalate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.4] synonym: "oxalic acid oxidase activity" EXACT [EC:1.2.3.4] xref: EC:1.2.3.4 xref: GO:0050162 xref: MetaCyc:OXALATE-OXIDASE-RXN is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0007516 name: oxaloacetate tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: keto-oxaloacetate = enol-oxaloacetate." [EC:5.3.2.2, MetaCyc:OXALOACETATE-TAUTOMERASE-RXN] synonym: "oxalacetic keto-enol isomerase activity" EXACT [EC:5.3.2.2] synonym: "oxaloacetate keto-enol tautomerase activity" EXACT [EC:5.3.2.2] synonym: "oxaloacetate keto-enol-isomerase activity" EXACT [EC:5.3.2.2] xref: EC:5.3.2.2 xref: GO:0050163 xref: MetaCyc:OXALOACETATE-TAUTOMERASE-RXN is_a: CCO:F0003424 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: CCO:F0007517 name: oxoglutarate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH." [EC:1.2.1.52, MetaCyc:OXOGLUTARATE-DEHYDROGENASE-(NADP+)-RXN] synonym: "2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.1.52] xref: EC:1.2.1.52 xref: GO:0050164 xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007518 name: pantetheine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN] synonym: "ATP:pantetheine 4'-phosphotransferase activity" EXACT [EC:2.7.1.34] synonym: "pantetheine kinase (phosphorylating)" EXACT [EC:2.7.1.34] xref: EC:2.7.1.34 xref: GO:0050165 xref: MetaCyc:PANTETHEINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007519 name: pantoate 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + NADH." [EC:1.1.1.106, MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN] synonym: "(R)-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106] synonym: "D-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106] synonym: "panthothenase activity" EXACT [EC:1.1.1.106] synonym: "pantoate dehydrogenase activity" EXACT [EC:1.1.1.106] xref: EC:1.1.1.106 xref: GO:0050166 xref: MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007520 name: pantothenoylcysteine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine = pantetheine + CO2." [EC:4.1.1.30, MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN] synonym: "N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30] synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)" EXACT [EC:4.1.1.30] synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30] synonym: "pantothenylcysteine decarboxylase activity" EXACT [EC:4.1.1.30] xref: EC:4.1.1.30 xref: GO:0050167 xref: MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007521 name: pentanamidase activity namespace: molecular_function def: "Catalysis of the reaction: pentanamide + H2O = pentanoate + NH3." [EC:3.5.1.50, MetaCyc:PENTANAMIDASE-RXN] synonym: "pentanamide amidohydrolase activity" EXACT [EC:3.5.1.50] synonym: "valeramidase activity" EXACT [EC:3.5.1.50] xref: EC:3.5.1.50 xref: GO:0050168 xref: MetaCyc:PENTANAMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007522 name: peptide-tryptophan 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine." [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-2] synonym: "peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.26] synonym: "peptidyltryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.26] synonym: "pyrrolooxygenase activity" EXACT [EC:1.13.11.26] synonym: "tryptophan pyrrolooxygenase activity" EXACT [EC:1.13.11.26] xref: EC:1.13.11.26 xref: GO:0050169 xref: MetaCyc:PEPTIDE-TRYPTOPHAN-2 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007523 name: peptidyl-glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3." [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN] synonym: "peptideglutaminase activity" EXACT [EC:3.5.1.43] synonym: "peptidoglutaminase activity" EXACT [EC:3.5.1.43] synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43] synonym: "peptidyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.43] xref: EC:3.5.1.43 xref: GO:0050170 xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007524 name: phenol beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside." [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "phenol b-glucosyltransferase activity" EXACT [] synonym: "phenol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDP glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDP-glucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDPglucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDPglucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.35] xref: EC:2.4.1.35 xref: GO:0050171 xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007525 name: phenylalanine 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O." [EC:1.13.12.9, MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN] subset: gosubset_prok synonym: "L-phenylalanine oxidase (deaminating and decarboxylating)" EXACT [EC:1.13.12.9] synonym: "l-phenylalanine oxidase (deaminating and decarboxylating) activity" EXACT [EC:1.13.12.9] synonym: "L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.9] synonym: "phenylalanine (deaminating, decarboxylating) oxidase activity" EXACT [EC:1.13.12.9] synonym: "phenylalanine (deaminating, decarboxylating)oxidase activity" EXACT [EC:1.13.12.9] xref: EC:1.13.12.9 xref: GO:0050172 xref: MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: CCO:F0007526 name: phenylalanine adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-phenylalanine = diphosphate + N-adenylyl-L-phenylalanine." [EC:2.7.7.54, MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN] synonym: "ATP:L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54] synonym: "ATP:phenylalanine adenylyltransferase activity" EXACT [] synonym: "L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54] xref: EC:2.7.7.54 xref: GO:0050173 xref: MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0007527 name: phenylalanine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN] synonym: "aromatic L-amino acid decarboxylase activity" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine carboxy-lyase activity" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine decarboxylase activity" EXACT [EC:4.1.1.53] xref: EC:4.1.1.53 xref: GO:0050174 xref: MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007528 name: phenylalanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH." [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "L-phenylalanine dehydrogenase activity" EXACT [EC:1.4.1.20] synonym: "L-phenylalanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.20] synonym: "PHD" RELATED [EC:1.4.1.20] synonym: "PheDH activity" EXACT [EC:1.4.1.20] xref: EC:1.4.1.20 xref: GO:0050175 xref: MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007529 name: phenylalanine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-phenylalanine = CoA + N-acetyl-L-phenylalanine." [EC:2.3.1.53, MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.53] synonym: "acetyl-CoA:L-phenylalanine N-acetyltransferase activity" EXACT [EC:2.3.1.53] xref: EC:2.3.1.53 xref: GO:0050176 xref: MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0007530 name: phenylpyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2." [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN] synonym: "phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)" EXACT [EC:4.1.1.43] synonym: "phenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.43] xref: EC:4.1.1.43 xref: GO:0050177 xref: MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007531 name: phenylpyruvate tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [EC:5.3.2.1, MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN] subset: gosubset_prok synonym: "phenylpyruvate keto--enol tautomerase activity" EXACT [EC:5.3.2.1] synonym: "phenylpyruvate keto-enol-isomerase activity" EXACT [EC:5.3.2.1] synonym: "phenylpyruvic keto--enol isomerase activity" EXACT [EC:5.3.2.1] xref: EC:5.3.2.1 xref: GO:0050178 xref: MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN is_a: CCO:F0003424 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: CCO:F0007532 name: phenylserine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threo-3-phenylserine = glycine + benzaldehyde." [EC:4.1.2.26, MetaCyc:PHENYLSERINE-ALDOLASE-RXN] synonym: "L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.26] synonym: "L-threo-3-phenylserine benzaldehyde-lyase activity" EXACT [EC:4.1.2.26] xref: EC:4.1.2.26 xref: GO:0050179 xref: MetaCyc:PHENYLSERINE-ALDOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007533 name: phloretin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phloretin + H2O = phloretate + phloroglucinol." [EC:3.7.1.4, MetaCyc:PHLORETIN-HYDROLASE-RXN] synonym: "2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity" EXACT [EC:3.7.1.4] synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.7.1.4] xref: EC:3.7.1.4 xref: GO:0050180 xref: MetaCyc:PHLORETIN-HYDROLASE-RXN is_a: CCO:F0003390 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: CCO:F0007534 name: phorbol-diester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate." [EC:3.1.1.51, MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN] synonym: "12,13-diacylphorbate 12-acylhydrolase activity" EXACT [EC:3.1.1.51] synonym: "diacylphorbate 12-hydrolase activity" EXACT [EC:3.1.1.51] synonym: "PDEH" RELATED [EC:3.1.1.51] synonym: "phorbol-12,13-diester 12-ester hydrolase activity" EXACT [EC:3.1.1.51] xref: EC:3.1.1.51 xref: GO:0050181 xref: MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007535 name: phosphate butyryltransferase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + phosphate = CoA + butanoylphosphate." [EC:2.3.1.19, MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN] subset: gosubset_prok synonym: "butanoyl-CoA:phosphate butanoyltransferase activity" EXACT [EC:2.3.1.19] synonym: "phosphotransbutyrylase activity" EXACT [EC:2.3.1.19] xref: EC:2.3.1.19 xref: GO:0050182 xref: MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007536 name: phosphatidylcholine 12-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + NAD+ + H2O." [EC:1.14.13.26, MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN] synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.26] synonym: "oleate D12-hydroxylase activity" EXACT [] synonym: "oleate Delta(12)-hydroxylase activity" EXACT [EC:1.14.13.26] synonym: "oleate delta12-hydroxylase activity" EXACT [EC:1.14.13.26] synonym: "oleate delta12-monooxygenase activity" EXACT [EC:1.14.13.26] synonym: "ricinoleic acid synthase activity" EXACT [EC:1.14.13.26] xref: EC:1.14.13.26 xref: GO:0050183 xref: MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007537 name: phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD+ = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + NADH." [EC:1.3.1.35, MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN] synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity" EXACT [EC:1.3.1.35] synonym: "linoleate synthase activity" EXACT [EC:1.3.1.35] synonym: "oleate desaturase activity" EXACT [EC:1.3.1.35] synonym: "oleoyl-CoA desaturase activity" EXACT [EC:1.3.1.35] synonym: "oleoylphosphatidylcholine desaturase activity" EXACT [EC:1.3.1.35] xref: EC:1.3.1.35 xref: GO:0050184 xref: MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007538 name: phosphatidylinositol deacylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-D-myo-inositol + H2O = 1-acylglycerophosphoinositol + a carboxylate." [EC:3.1.1.52, MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN] synonym: "1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity" EXACT [EC:3.1.1.52] synonym: "phosphatidylinositol phospholipase A2 activity" EXACT [EC:3.1.1.52] xref: EC:3.1.1.52 xref: GO:0050185 xref: MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007539 name: phosphoadenylylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + SO4(2-) (sulfate)." [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN] synonym: "3'-phosphoadenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.2] synonym: "3-phosphoadenosine 5-phosphosulfate sulfatase activity" EXACT [EC:3.6.2.2] synonym: "3-phosphoadenylyl sulfatase activity" EXACT [EC:3.6.2.2] synonym: "PAPS sulfatase activity" EXACT [EC:3.6.2.2] synonym: "phosphoadenylylsulphatase activity" EXACT [] xref: EC:3.6.2.2 xref: GO:0050186 xref: MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN is_a: CCO:F0003387 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides [Term] id: CCO:F0007540 name: phosphoamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate." [EC:3.9.1.1, MetaCyc:PHOSPHOAMIDASE-RXN] synonym: "creatine phosphatase activity" EXACT [EC:3.9.1.1] synonym: "phosphamide hydrolase activity" EXACT [EC:3.9.1.1] xref: EC:3.9.1.1 xref: GO:0050187 xref: MetaCyc:PHOSPHOAMIDASE-RXN is_a: CCO:F0003392 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds [Term] id: CCO:F0007541 name: phosphoenolpyruvate mutase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate." [EC:5.4.2.9, MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN] subset: gosubset_prok synonym: "PEP mutase activity" EXACT [EC:5.4.2.9] synonym: "PEP phosphomutase activity" EXACT [EC:5.4.2.9] synonym: "PEPPM" RELATED [EC:5.4.2.9] synonym: "phosphoenolpyruvate 2,3-phosphonomutase activity" EXACT [EC:5.4.2.9] synonym: "phosphoenolpyruvate phosphomutase activity" EXACT [EC:5.4.2.9] synonym: "phosphoenolpyruvate-phosphonopyruvate phosphomutase activity" EXACT [EC:5.4.2.9] xref: EC:5.4.2.9 xref: GO:0050188 xref: MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN is_a: CCO:F0003429 ! intramolecular transferase activity, phosphotransferases [Term] id: CCO:F0007542 name: phosphoenolpyruvate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + H2O = pyruvate + phosphate." [EC:3.1.3.60, MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN] synonym: "PEP phosphatase activity" EXACT [EC:3.1.3.60] synonym: "phosphoenolpyruvate phosphohydrolase activity" EXACT [EC:3.1.3.60] xref: EC:3.1.3.60 xref: GO:0050189 xref: MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007543 name: phosphoglucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucose 1-phosphate = ADP + D-glucose 1,6-bisphosphate." [EC:2.7.1.10, MetaCyc:PHOSPHOGLUCOKINASE-RXN] synonym: "ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10] synonym: "ATP:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10] synonym: "glucose-phosphate kinase activity" EXACT [EC:2.7.1.10] synonym: "phosphoglucokinase (phosphorylating)" EXACT [EC:2.7.1.10] xref: EC:2.7.1.10 xref: GO:0050190 xref: MetaCyc:PHOSPHOGLUCOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007544 name: phosphoglycerate kinase (GTP) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3-phospho-D-glycerate = GDP + 3-phospho-D-glyceroyl phosphate." [EC:2.7.2.10, MetaCyc:PHOSPHOGLYCERATE-KINASE-(GTP)-RXN] synonym: "GTP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.10] xref: EC:2.7.2.10 xref: GO:0050191 xref: MetaCyc:PHOSPHOGLYCERATE-KINASE-(GTP)-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003346 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: CCO:F0007545 name: phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate 2-phosphate + H2O = D-glycerate + phosphate." [EC:3.1.3.20, MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN] synonym: "D-2-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.20] synonym: "D-glycerate-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.20] synonym: "glycerophosphate phosphatase activity" EXACT [EC:3.1.3.20] xref: EC:3.1.3.20 xref: GO:0050192 xref: MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007546 name: phosphoketolase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O." [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN] subset: gosubset_prok synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.9] synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.9] synonym: "xylulose-5-phosphate phosphoketolase activity" EXACT [EC:4.1.2.9] xref: EC:4.1.2.9 xref: GO:0050193 xref: MetaCyc:PHOSPHOKETOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007547 name: phosphonoacetaldehyde hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phosphonoacetaldehyde + H2O = acetaldehyde + phosphate." [EC:3.11.1.1, MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN] subset: gosubset_prok synonym: "2-oxoethylphosphonate phosphonohydrolase activity" EXACT [EC:3.11.1.1] synonym: "2-phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1] synonym: "phosphonatase activity" EXACT [EC:3.11.1.1] synonym: "phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1] xref: EC:3.11.1.1 xref: GO:0050194 xref: MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN is_a: CCO:F0003394 ! hydrolase activity, acting on acid carbon-phosphorus bonds [Term] id: CCO:F0007548 name: phosphoribokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribose 5-phosphate = ADP + D-ribose 1,5-bisphosphate." [EC:2.7.1.18, MetaCyc:PHOSPHORIBOKINASE-RXN] synonym: "ATP:D-ribose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.18] synonym: "phosphoribokinase (phosphorylating)" EXACT [EC:2.7.1.18] xref: EC:2.7.1.18 xref: GO:0050195 xref: MetaCyc:PHOSPHORIBOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007550 name: phytanate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phytanate + CoA = AMP + diphosphate + phytanoyl-CoA." [EC:6.2.1.24, MetaCyc:PHYTANATE--COA-LIGASE-RXN] subset: gosubset_prok synonym: "phytanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.24] synonym: "phytanoyl-CoA ligase activity" EXACT [EC:6.2.1.24] xref: EC:6.2.1.24 xref: GO:0050197 xref: MetaCyc:PHYTANATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007551 name: pinosylvin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + pinosylvin + 4 CO2." [EC:2.3.1.146, MetaCyc:PINOSYLVIN-SYNTHASE-RXN] synonym: "malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.146] synonym: "pine stilbene synthase activity" EXACT [EC:2.3.1.146] synonym: "stilbene synthase activity" BROAD [EC:2.3.1.146] xref: EC:2.3.1.146 xref: GO:0050198 xref: MetaCyc:PINOSYLVIN-SYNTHASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007552 name: piperidine N-piperoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = CoA + N-[(E,E)-piperoyl]-piperidine." [EC:2.3.1.145, MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN] synonym: "(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145] synonym: "piperidine piperoyltransferase activity" EXACT [EC:2.3.1.145] synonym: "piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145] xref: EC:2.3.1.145 xref: GO:0050199 xref: MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007553 name: plasmalogen synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine." [EC:2.3.1.25, MetaCyc:PLASMALOGEN-SYNTHASE-RXN] synonym: "1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.25] synonym: "acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity" EXACT [EC:2.3.1.25] synonym: "lysoplasmenylcholine acyltransferase activity" EXACT [EC:2.3.1.25] synonym: "O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.25] xref: EC:2.3.1.25 xref: GO:0050200 xref: MetaCyc:PLASMALOGEN-SYNTHASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007554 name: fucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 6-deoxy-L-galactose = ADP + 6-deoxy-L-galactose 1-phosphate." [EC:2.7.1.52, MetaCyc:FUCOKINASE-RXN] synonym: "ATP:6-deoxy-L-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.52] synonym: "ATP:beta-L-fucose 1-phosphotransferase activity" EXACT [EC:2.7.1.52] synonym: "fucokinase (phosphorylating) activity" EXACT [EC:2.7.1.52] synonym: "fucose kinase activity" EXACT [EC:2.7.1.52] synonym: "L-fucokinase activity" EXACT [EC:2.7.1.52] synonym: "L-fucose kinase activity" EXACT [EC:2.7.1.52] xref: EC:2.7.1.52 xref: GO:0050201 xref: MetaCyc:FUCOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007555 name: octopamine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH3." [EC:4.2.1.87, MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN] synonym: "octopamine hydro-lyase (deaminating)" EXACT [EC:4.2.1.87] synonym: "octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]" RELATED [EC:4.2.1.87] synonym: "octopamine hydrolyase activity" EXACT [EC:4.2.1.87] xref: EC:4.2.1.87 xref: GO:0050202 xref: MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007556 name: oxalate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oxalate + CoA = AMP + diphosphate + oxalyl-CoA." [EC:6.2.1.8, MetaCyc:OXALATE--COA-LIGASE-RXN] synonym: "oxalate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.8] synonym: "oxalyl coenzyme A synthetase activity" EXACT [EC:6.2.1.8] synonym: "oxalyl-CoA synthetase activity" EXACT [EC:6.2.1.8] xref: EC:6.2.1.8 xref: GO:0050203 xref: MetaCyc:OXALATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007557 name: oxalomalate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxalomalate = oxaloacetate + glyoxylate." [EC:4.1.3.13, MetaCyc:OXALOMALATE-LYASE-RXN] synonym: "3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)" EXACT [EC:4.1.3.13] synonym: "3-oxalomalate glyoxylate-lyase activity" EXACT [EC:4.1.3.13] xref: EC:4.1.3.13 xref: GO:0050204 xref: MetaCyc:OXALOMALATE-LYASE-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0007558 name: oxamate carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + oxamate = phosphate + oxalureate." [EC:2.1.3.5, MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN] synonym: "carbamoyl-phosphate:oxamate carbamoyltransferase activity" EXACT [EC:2.1.3.5] synonym: "oxamic transcarbamylase activity" EXACT [EC:2.1.3.5] xref: EC:2.1.3.5 xref: GO:0050205 xref: MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN is_a: CCO:F0003319 ! carboxyl- or carbamoyltransferase activity [Term] id: CCO:F0007559 name: oximinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate oxime + acetone = pyruvate + acetone oxime." [EC:2.6.3.1, MetaCyc:OXIMINOTRANSFERASE-RXN] synonym: "oximase activity" EXACT [EC:2.6.3.1] synonym: "pyruvate-acetone oximinotransferase activity" EXACT [EC:2.6.3.1] synonym: "pyruvate-oxime:acetone oximinotransferase activity" EXACT [EC:2.6.3.1] synonym: "transoximase activity" EXACT [EC:2.6.3.1] synonym: "transoximinase activity" EXACT [EC:2.6.3.1] xref: EC:2.6.3.1 xref: GO:0050206 xref: MetaCyc:OXIMINOTRANSFERASE-RXN is_a: CCO:F0003343 ! oximinotransaminase activity [Term] id: CCO:F0007560 name: plasmanylethanolamine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O." [EC:1.14.99.19, MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN] synonym: "1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19] synonym: "1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19] synonym: "alkylacylglycero-phosphorylethanolamine dehydrogenase activity" EXACT [EC:1.14.99.19] synonym: "alkylacylglycerophosphoethanolamine desaturase activity" EXACT [EC:1.14.99.19] synonym: "dehydrogenase, alkyl-acylglycerophosphorylethanolamine" EXACT [EC:1.14.99.19] synonym: "O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.19] synonym: "plasmenylethanolamine desaturase activity" EXACT [] xref: EC:1.14.99.19 xref: GO:0050207 xref: MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007561 name: polysialic-acid O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [EC:2.3.1.136] synonym: "lecithin retinol acyl transferase activity" EXACT [EC:2.3.1.136] synonym: "lecithin:retinol acyltransferase activity" EXACT [EC:2.3.1.136] synonym: "LRAT" RELATED [EC:2.3.1.136] synonym: "retinyl ester synthase activity" EXACT [EC:2.3.1.136] xref: EC:2.3.1.136 xref: GO:0050208 xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0007562 name: polyvinyl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2." [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN] synonym: "dehydrogenase, polyvinyl alcohol" EXACT [EC:1.1.3.30] synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.30] synonym: "PVA oxidase activity" EXACT [EC:1.1.3.30] xref: EC:1.1.3.30 xref: GO:0050209 xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007563 name: prenyl-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate." [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN] synonym: "prenol pyrophosphatase activity" EXACT [EC:3.1.7.1] synonym: "prenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.1] synonym: "prenyl-pyrophosphatase activity" EXACT [] synonym: "prenylphosphatase activity" EXACT [EC:3.1.7.1] xref: EC:3.1.7.1 xref: GO:0050210 xref: MetaCyc:PRENYL-PYROPHOSPHATASE-RXN is_a: CCO:F0003364 ! diphosphoric monoester hydrolase activity [Term] id: CCO:F0007564 name: procollagen galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN] synonym: "collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "collagen hydroxylysyl galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "hydroxylysine galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDP galactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "uridine diphosphogalactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] xref: EC:2.4.1.50 xref: GO:0050211 xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0007565 name: progesterone 11-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: progesterone + donor-H2 + O2 = 11-alpha-hydroxyprogesterone + acceptor + H2O." [EC:1.14.99.14, MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN] synonym: "progesterone 11-alpha-hydroxylase activity" EXACT [EC:1.14.99.14] synonym: "progesterone 11a-monooxygenase activity" EXACT [] synonym: "progesterone 11alpha-hydroxylase activity" EXACT [EC:1.14.99.14] synonym: "progesterone 11alpha-monooxygenase activity" EXACT [EC:1.14.99.14] synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)" EXACT [EC:1.14.99.14] xref: EC:1.14.99.14 xref: GO:0050212 xref: MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007566 name: progesterone 5-alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH." [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN] synonym: "5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.30] synonym: "delta4-steroid 5alpha-reductase (progesterone)" EXACT [EC:1.3.1.30] synonym: "progesterone 5a-reductase activity" EXACT [] synonym: "progesterone 5alpha-reductase activity" EXACT [EC:1.3.1.30] synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.1.30] xref: EC:1.3.1.30 xref: GO:0050213 xref: MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007567 name: progesterone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: progesterone + donor-H2 + O2 = testosterone acetate + acceptor + H2O." [EC:1.14.99.4, MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN] synonym: "progesterone hydroxylase activity" EXACT [EC:1.14.99.4] synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.4] xref: EC:1.14.99.4 xref: GO:0050214 xref: MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007568 name: propanediol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,2-diol = propanal + H2O." [EC:4.2.1.28, MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN] subset: gosubset_prok synonym: "1,2-propanediol dehydratase activity" EXACT [EC:4.2.1.28] synonym: "adenosylcobalamin-dependent diol dehydratase activity" EXACT [EC:4.2.1.28] synonym: "coenzyme B12-dependent diol dehydrase activity" EXACT [EC:4.2.1.28] synonym: "diol dehydrase activity" EXACT [EC:4.2.1.28] synonym: "diol dehydratase activity" EXACT [EC:4.2.1.28] synonym: "dioldehydratase activity" EXACT [EC:4.2.1.28] synonym: "DL-1,2-propanediol hydro-lyase activity" EXACT [EC:4.2.1.28] synonym: "meso-2,3-butanediol dehydrase activity" EXACT [EC:4.2.1.28] synonym: "propane-1,2-diol hydro-lyase (propanal-forming)" EXACT [EC:4.2.1.28] synonym: "propane-1,2-diol hydro-lyase activity" EXACT [EC:4.2.1.28] synonym: "propanediol dehydrase activity" EXACT [EC:4.2.1.28] xref: EC:4.2.1.28 xref: GO:0050215 xref: MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007569 name: propanediol-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,2-diol 1-phosphate + NAD+ = hydroxyacetone phosphate + NADH." [EC:1.1.1.7, MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN] xref: EC:1.1.1.7 xref: GO:0050216 xref: MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007570 name: propioin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 propanal = 4-hydroxy-3-hexanone." [EC:4.1.2.35, MetaCyc:PROPIOIN-SYNTHASE-RXN] synonym: "4-hydroxy-3-hexanone aldolase activity" EXACT [EC:4.1.2.35] synonym: "4-hydroxy-3-hexanone propanal-lyase (propanal-forming)" EXACT [EC:4.1.2.35] synonym: "4-hydroxy-3-hexanone propanal-lyase activity" EXACT [EC:4.1.2.35] xref: EC:4.1.2.35 xref: GO:0050217 xref: MetaCyc:PROPIOIN-SYNTHASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007571 name: propionate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN] subset: gosubset_prok synonym: "propanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.17] synonym: "propionyl-CoA synthetase activity" EXACT [EC:6.2.1.17] xref: EC:6.2.1.17 xref: GO:0050218 xref: MetaCyc:PROPIONATE--COA-LIGASE-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007572 name: prostaglandin-A1 delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate." [EC:5.3.3.9, MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN] synonym: "(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity" EXACT [EC:5.3.3.9] synonym: "prostaglandin A isomerase activity" EXACT [EC:5.3.3.9] synonym: "prostaglandin-A1 D-isomerase activity" EXACT [] xref: EC:5.3.3.9 xref: GO:0050219 xref: MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0007573 name: prostaglandin-E synthase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate." [EC:5.3.99.3, MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [EC:5.3.99.3] synonym: "endoperoxide isomerase activity" EXACT [EC:5.3.99.3] synonym: "PGE isomerase activity" EXACT [EC:5.3.99.3] synonym: "PGE2 isomerase activity" EXACT [EC:5.3.99.3] synonym: "PGH-PGE isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin endoperoxide E isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin endoperoxide E2 isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin H-E isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin R-prostaglandin E isomerase activity" EXACT [EC:5.3.99.3] synonym: "Prostaglandin-H(2) E-isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin-H2 E-isomerase activity" EXACT [EC:5.3.99.3] xref: EC:5.3.99.3 xref: GO:0050220 xref: MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN is_a: CCO:F0003422 ! intramolecular oxidoreductase activity [Term] id: CCO:F0007574 name: prostaglandin-E2 9-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN] synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity" EXACT [EC:1.1.1.189] synonym: "9-keto-prostaglandin E(2) reductase activity" EXACT [EC:1.1.1.189] synonym: "9-keto-prostaglandin E2 reductase activity" EXACT [EC:1.1.1.189] synonym: "9-ketoprostaglandin reductase activity" EXACT [EC:1.1.1.189] synonym: "PGE(2) 9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE-9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2 9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2-9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2-9-OR" RELATED [EC:1.1.1.189] synonym: "prostaglandin E 9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "prostaglandin E2-9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "prostaglandin-E(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "prostaglandin-E2 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "reductase, 15-hydroxy-9-oxoprostaglandin" EXACT [EC:1.1.1.189] xref: EC:1.1.1.189 xref: GO:0050221 xref: MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007575 name: protocatechuate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxybenzoate = catechol + CO2." [EC:4.1.1.63, MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN] synonym: "3,4-dihydrobenzoate decarboxylase activity" EXACT [EC:4.1.1.63] synonym: "3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.63] synonym: "3,4-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.63] synonym: "protocatechuate carboxy-lyase activity" EXACT [EC:4.1.1.63] xref: EC:4.1.1.63 xref: GO:0050223 xref: MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007576 name: prunasin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile." [EC:3.2.1.118, MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN] synonym: "prunasin b-glucosidase activity" EXACT [] synonym: "prunasin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.118] synonym: "prunasin hydrolase activity" EXACT [EC:3.2.1.118] xref: EC:3.2.1.118 xref: GO:0050224 xref: MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007577 name: pseudouridine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pseudouridine = ADP + pseudouridine 5'-phosphate." [EC:2.7.1.83, MetaCyc:PSEUDOURIDINE-KINASE-RXN] synonym: "ATP:pseudouridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.83] synonym: "pseudouridine kinase (phosphorylating)" EXACT [EC:2.7.1.83] xref: EC:2.7.1.83 xref: GO:0050225 xref: MetaCyc:PSEUDOURIDINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007578 name: psychosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate." [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity" EXACT [EC:2.8.2.13] synonym: "3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity" EXACT [EC:2.8.2.13] synonym: "PAPS:psychosine sulphotransferase activity" EXACT [EC:2.8.2.13] synonym: "psychosine sulphotransferase activity" EXACT [] xref: EC:2.8.2.13 xref: GO:0050226 xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007579 name: pteridine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown." [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN] synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.17.3.1] xref: EC:1.17.3.1 xref: GO:0050227 xref: MetaCyc:PTERIDINE-OXIDASE-RXN is_a: CCO:F0003309 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: CCO:F0007580 name: pterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3." [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN] synonym: "2-amino-4-hydroxypteridine aminohydrolase activity" EXACT [EC:3.5.4.11] synonym: "acrasinase activity" EXACT [EC:3.5.4.11] xref: EC:3.5.4.11 xref: GO:0050228 xref: MetaCyc:PTERIN-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0007581 name: pterocarpin synthase activity namespace: molecular_function def: "Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH." [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN] synonym: "medicarpin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.246] synonym: "pterocarpan synthase activity" EXACT [EC:1.1.1.246] xref: EC:1.1.1.246 xref: GO:0050229 xref: MetaCyc:PTEROCARPIN-SYNTHASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007582 name: purine imidazole-ring cyclase activity namespace: molecular_function def: "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O." [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN] synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)" EXACT [EC:4.3.2.4] synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4] synonym: "DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4] xref: EC:4.3.2.4 xref: GO:0050230 xref: MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN is_a: CCO:F0002427 ! cyclase activity is_a: CCO:F0003407 ! amidine-lyase activity [Term] id: CCO:F0007583 name: putrescine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + putrescine = phosphate + N-carbamoylputrescine." [EC:2.1.3.6, MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN] subset: gosubset_prok synonym: "carbamoyl-phosphate:putrescine carbamoyltransferase activity" EXACT [EC:2.1.3.6] synonym: "PTCase activity" EXACT [EC:2.1.3.6] synonym: "putrescine synthase activity" EXACT [EC:2.1.3.6] synonym: "putrescine transcarbamylase activity" EXACT [EC:2.1.3.6] xref: EC:2.1.3.6 xref: GO:0050231 xref: MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN is_a: CCO:F0003319 ! carboxyl- or carbamoyltransferase activity [Term] id: CCO:F0007584 name: putrescine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN] subset: gosubset_prok synonym: "putrescine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.10] xref: EC:1.4.3.10 xref: GO:0050232 xref: MetaCyc:PUTRESCINE-OXIDASE-RXN is_a: CCO:F0003241 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: CCO:F0007585 name: pyranose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2." [EC:1.1.3.10, MetaCyc:PYRANOSE-OXIDASE-RXN] synonym: "glucose 2-oxidase activity" EXACT [EC:1.1.3.10] synonym: "pyranose-2-oxidase activity" EXACT [EC:1.1.3.10] synonym: "pyranose:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.10] xref: EC:1.1.3.10 xref: GO:0050233 xref: MetaCyc:PYRANOSE-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007586 name: pyrazolylalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O." [EC:4.2.1.50, MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN] synonym: "beta-pyrazolylalaninase activity" EXACT [EC:4.2.1.50] synonym: "L-serine hydro-lyase (adding pyrazole)" EXACT [EC:4.2.1.50] synonym: "L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]" RELATED [EC:4.2.1.50] xref: EC:4.2.1.50 xref: GO:0050234 xref: MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007587 name: pyridoxal 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxal + NAD+ = 4-pyridoxolactone + NADH." [EC:1.1.1.107, MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN] synonym: "pyridoxal dehydrogenase activity" EXACT [EC:1.1.1.107] synonym: "pyridoxal:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.107] xref: EC:1.1.1.107 xref: GO:0050235 xref: MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007588 name: pyridoxine 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + NADP+ = pyridoxal + NADPH." [EC:1.1.1.65, MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN] synonym: "PL reductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxal reductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxin dehydrogenase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxine dehydrogenase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxine:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxol dehydrogenase activity" EXACT [EC:1.1.1.65] xref: EC:1.1.1.65 xref: GO:0050236 xref: MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN is_a: CCO:F0000511 ! aldo-keto reductase activity [Term] id: CCO:F0007589 name: pyridoxine 4-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2." [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN] synonym: "pyridoxin 4-oxidase activity" EXACT [EC:1.1.3.12] synonym: "pyridoxine:oxygen 4-oxidoreductase activity" EXACT [EC:1.1.3.12] synonym: "pyridoxol 4-oxidase activity" EXACT [EC:1.1.3.12] xref: EC:1.1.3.12 xref: GO:0050237 xref: MetaCyc:PYRIDOXINE-4-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007590 name: pyridoxine 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor." [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN] synonym: "pyridoxal-5-dehydrogenase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxin 5-dehydrogenase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxine 5'-dehydrogenase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxine:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxine:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxol 5-dehydrogenase activity" EXACT [EC:1.1.99.9] xref: EC:1.1.99.9 xref: GO:0050238 xref: MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007591 name: pyrithiamine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3." [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN] synonym: "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity" EXACT [EC:3.5.4.20] xref: EC:3.5.4.20 xref: GO:0050239 xref: MetaCyc:PYRITHIAMIN-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0007592 name: pyrogallol 1,2-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2,3-trihydroxybenzene + O2 = (Z)-5-oxohex-2-enedioate." [EC:1.13.11.35, MetaCyc:PYROGALLOL-1] synonym: "1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.35] synonym: "pyrogallol 1,2-dioxygenase activity" EXACT [EC:1.13.11.35] xref: EC:1.13.11.35 xref: GO:0050240 xref: MetaCyc:PYROGALLOL-1 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007593 name: pyrroline-2-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN] synonym: "delta1-pyrroline-2-carboxylate reductase activity" EXACT [EC:1.5.1.1] synonym: "L-proline:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.5.1.1] xref: EC:1.5.1.1 xref: GO:0050241 xref: MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007594 name: pyruvate, phosphate dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate." [EC:2.7.9.1, MetaCyc:PYRUVATE] subset: gosubset_prok synonym: "ATP:pyruvate, phosphate phosphotransferase activity" EXACT [EC:2.7.9.1] synonym: "orthophosphate dikinase pyruvate" RELATED [EC:2.7.9.1] synonym: "PPDK" RELATED [EC:2.7.9.1] synonym: "pyruvate, Pi dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate,orthophosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate,phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate-inorganic phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate-phosphate dikinase (phosphorylating)" EXACT [EC:2.7.9.1] synonym: "pyruvate-phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate-phosphate ligase activity" EXACT [EC:2.7.9.1] synonym: "pyruvic-phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvic-phosphate ligase activity" EXACT [EC:2.7.9.1] xref: EC:2.7.9.1 xref: GO:0050242 xref: MetaCyc:PYRUVATE is_a: CCO:F0003353 ! phosphotransferase activity, paired acceptors [Term] id: CCO:F0007595 name: pyruvate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH." [EC:1.2.1.51, MetaCyc:PYRUVATE-DEHYDROGENASE-(NADP+)-RXN] synonym: "pyruvate:NADP(+) oxidoreductase activity" EXACT [EC:1.2.1.51] synonym: "pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.51] synonym: "pyruvate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.51] xref: EC:1.2.1.51 xref: GO:0050243 xref: MetaCyc:PYRUVATE-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0001103 ! pyruvate dehydrogenase activity is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007596 name: pyruvate oxidase (CoA-acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + O2 = acetyl-CoA + CO2 + H2O2." [EC:1.2.3.6, MetaCyc:PYRUVATE-OXIDASE-(COA-ACETYLATING)-RXN] synonym: "pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.3.6] xref: EC:1.2.3.6 xref: GO:0050244 xref: MetaCyc:PYRUVATE-OXIDASE-(COA-ACETYLATING)-RXN is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0007597 name: quercitrinase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + quercitrin = L-rhamnose + quercetin." [EC:3.2.1.66, MetaCyc:QUERCITRINASE-RXN] synonym: "quercitrin 3-L-rhamnohydrolase activity" EXACT [EC:3.2.1.66] xref: EC:3.2.1.66 xref: GO:0050245 xref: MetaCyc:QUERCITRINASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007598 name: questin monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: questin + NADPH + O2 = sulochrin + NADP+ + H2O." [EC:1.14.13.43, MetaCyc:QUESTIN-MONOOXYGENASE-RXN] synonym: "questin oxygenase activity" EXACT [EC:1.14.13.43] synonym: "questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)" EXACT [EC:1.14.13.43] xref: EC:1.14.13.43 xref: GO:0050246 xref: MetaCyc:QUESTIN-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007599 name: raucaffricine beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine." [EC:3.2.1.125, MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN] synonym: "raucaffricine b-glucosidase activity" EXACT [] synonym: "raucaffricine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.125] synonym: "raucaffricine beta-D-glucosidase activity" EXACT [EC:3.2.1.125] synonym: "raucaffricine glucosidase activity" EXACT [EC:3.2.1.125] xref: EC:3.2.1.125 xref: GO:0050247 xref: MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007600 name: Renilla-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light." [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN] synonym: "aequorin activity" NARROW [EC:1.13.12.5] synonym: "luciferase (Renilla luciferin)" EXACT [EC:1.13.12.5] synonym: "luciferase activity" BROAD [EC:1.13.12.5] synonym: "Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.5] synonym: "Renilla-type luciferase activity" EXACT [EC:1.13.12.5] synonym: "renilla-type luciferase activity" EXACT [EC:1.13.12.5] xref: EC:1.13.12.5 xref: GO:0050248 xref: MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: CCO:F0006100 ! luciferin monooxygenase activity [Term] id: CCO:F0007601 name: Renilla-luciferin sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + Renilla luciferin = adenosine 3',5'-bisphosphate + luciferyl sulfate." [EC:2.8.2.10, MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity" EXACT [EC:2.8.2.10] synonym: "luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)" EXACT [EC:2.8.2.10] synonym: "luciferin sulfokinase activity" EXACT [EC:2.8.2.10] synonym: "luciferin sulfotransferase activity" BROAD [EC:2.8.2.10] synonym: "Renilla-luciferin sulphotransferase activity" EXACT [] xref: EC:2.8.2.10 xref: GO:0050249 xref: MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007602 name: retinal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2." [EC:1.2.3.11, MetaCyc:RETINAL-OXIDASE-RXN] synonym: "retinal:oxygen oxidoreductase activity" EXACT [EC:1.2.3.11] synonym: "retinene oxidase activity" RELATED [EC:1.2.3.11] xref: EC:1.2.3.11 xref: GO:0050250 xref: MetaCyc:RETINAL-OXIDASE-RXN is_a: CCO:F0003225 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: CCO:F0007603 name: retinol isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinol = 11-cis-retinol." [EC:5.2.1.7, MetaCyc:RETINOL-ISOMERASE-RXN] synonym: "all-trans-retinol 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.7] synonym: "all-trans-retinol isomerase activity" EXACT [EC:5.2.1.7] xref: EC:5.2.1.7 xref: GO:0050251 xref: MetaCyc:RETINOL-ISOMERASE-RXN is_a: CCO:F0003421 ! cis-trans isomerase activity [Term] id: CCO:F0007604 name: retinol O-fatty-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester." [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:retinol O-acyltransferase activity" EXACT [EC:2.3.1.76] synonym: "retinol acyltransferase activity" EXACT [EC:2.3.1.76] synonym: "retinol fatty-acyltransferase activity" EXACT [EC:2.3.1.76] xref: EC:2.3.1.76 xref: GO:0050252 xref: MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0007605 name: retinyl-palmitate esterase activity namespace: molecular_function def: "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate." [EC:3.1.1.21, MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN] synonym: "retinyl ester hydrolase activity" EXACT [EC:3.1.1.21] synonym: "retinyl palmitate hydrolase activity" EXACT [EC:3.1.1.21] synonym: "retinyl palmitate hydrolyase activity" EXACT [EC:3.1.1.21] synonym: "retinyl-palmitate palmitohydrolase activity" EXACT [EC:3.1.1.21] xref: EC:3.1.1.21 xref: GO:0050253 xref: MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007606 name: rhodopsin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] synonym: "ATP:rhodopsin phosphotransferase activity" EXACT [EC:2.7.11.14] synonym: "cone opsin kinase activity" NARROW [EC:2.7.11.14] synonym: "G-protein-coupled receptor kinase 1 activity" NARROW [EC:2.7.11.14] synonym: "GPCR kinase 1 activity" NARROW [EC:2.7.11.14] synonym: "GRK1" RELATED [EC:2.7.11.14] synonym: "GRK7" RELATED [EC:2.7.11.14] synonym: "opsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14] synonym: "opsin kinase activity" EXACT [EC:2.7.11.14] synonym: "rhodopsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14] synonym: "RK" RELATED [EC:2.7.11.14] synonym: "STK14" RELATED [EC:2.7.11.14] xref: EC:2.7.11.14 xref: GO:0050254 xref: MetaCyc:RHODOPSIN-KINASE-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0007607 name: ribitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: ribitol + NAD+ = D-ribulose + NADH." [EC:1.1.1.56, MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "adonitol dehydrogenase activity" EXACT [EC:1.1.1.56] synonym: "ribitol dehydrogenase A (wild type)" RELATED [EC:1.1.1.56] synonym: "ribitol dehydrogenase B (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] synonym: "ribitol dehydrogenase D (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] synonym: "ribitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.56] xref: EC:1.1.1.56 xref: GO:0050255 xref: MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007608 name: ribitol-5-phosphate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+." [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.137] synonym: "dehydrogenase, ribitol 5-phosphate" EXACT [EC:1.1.1.137] xref: EC:1.1.1.137 xref: GO:0050256 xref: MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007609 name: riboflavin phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 1-phosphate + riboflavin = D-glucose + FMN." [EC:2.7.1.42, MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN] synonym: "alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42] synonym: "D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42] synonym: "G-1-P phosphotransferase activity" EXACT [EC:2.7.1.42] synonym: "riboflavine phosphotransferase activity" EXACT [EC:2.7.1.42] xref: EC:2.7.1.42 xref: GO:0050257 xref: MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007610 name: riboflavinase activity namespace: molecular_function def: "Catalysis of the reaction: riboflavin + H2O = ribitol + lumichrome." [EC:3.5.99.1, MetaCyc:RIBOFLAVINASE-RXN] synonym: "riboflavin hydrolase activity" EXACT [EC:3.5.99.1] xref: EC:3.5.99.1 xref: GO:0050258 xref: MetaCyc:RIBOFLAVINASE-RXN is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0007611 name: ribose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose + NADP+ + H2O = D-ribonate + NADPH." [EC:1.1.1.115, MetaCyc:RIBOSE-1-DEHYDROGENASE-(NADP+)-RXN] synonym: "D-ribose dehydrogenase (NADP+)" EXACT [EC:1.1.1.115] synonym: "D-ribose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.115] synonym: "NADP-pentose-dehydrogenase activity" EXACT [EC:1.1.1.115] xref: EC:1.1.1.115 xref: GO:0050259 xref: MetaCyc:RIBOSE-1-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007612 name: ribose-5-phosphate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ribose 5-phosphate + NH3 = ADP + phosphate + 5-phosphoribosylamine." [EC:6.3.4.7, MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN] synonym: "5-phosphoribosylamine synthetase activity" EXACT [EC:6.3.4.7] synonym: "ammonia-ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7] synonym: "ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7] synonym: "ribose-5-phosphate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.7] xref: EC:6.3.4.7 xref: GO:0050260 xref: MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0007613 name: ribose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose = D-ribulose." [EC:5.3.1.20, MetaCyc:RIBOSE-ISOMERASE-RXN] synonym: "D-ribose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.20] synonym: "D-ribose isomerase activity" EXACT [EC:5.3.1.20] synonym: "D-ribose ketol-isomerase activity" EXACT [EC:5.3.1.20] xref: EC:5.3.1.20 xref: GO:0050261 xref: MetaCyc:RIBOSE-ISOMERASE-RXN is_a: CCO:F0003423 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: CCO:F0007614 name: ribosylnicotinamide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide." [EC:2.7.1.22, MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN] synonym: "ATP:N-ribosylnicotinamide 5'-phosphotransferase activity" EXACT [EC:2.7.1.22] synonym: "ribosylnicotinamide kinase (phosphorylating)" EXACT [EC:2.7.1.22] xref: EC:2.7.1.22 xref: GO:0050262 xref: MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007615 name: ribosylpyrimidine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN] synonym: "N-ribosylpyrimidine nucleosidase activity" EXACT [EC:3.2.2.8] synonym: "N-ribosylpyrimidine ribohydrolase activity" EXACT [EC:3.2.2.8] synonym: "nucleoside ribohydrolase activity" BROAD [EC:3.2.2.8] synonym: "pyrimidine nucleosidase activity" EXACT [EC:3.2.2.8] synonym: "pyrimidine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.8] synonym: "RihB" RELATED [EC:3.2.2.8] synonym: "YeiK" RELATED [EC:3.2.2.8] xref: EC:3.2.2.8 xref: GO:0050263 xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN is_a: CCO:F0003369 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: CCO:F0007616 name: rifamycin-B oxidase activity namespace: molecular_function def: "Catalysis of the reaction: rifamycin B + O2 = rifamycin O + H2O2." [EC:1.10.3.6, MetaCyc:RIFAMYCIN-B-OXIDASE-RXN] synonym: "rifamycin B oxidase activity" EXACT [EC:1.10.3.6] synonym: "rifamycin-B-oxidase activity" EXACT [] synonym: "rifamycin-B:oxygen oxidoreductase activity" EXACT [EC:1.10.3.6] xref: EC:1.10.3.6 xref: GO:0050264 xref: MetaCyc:RIFAMYCIN-B-OXIDASE-RXN is_a: CCO:F0003273 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: CCO:F0007617 name: RNA uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN] synonym: "terminal uridylyltransferase activity" EXACT [EC:2.7.7.52] synonym: "TUT activity" EXACT [EC:2.7.7.52] synonym: "UTP:RNA uridylyltransferase activity" EXACT [] xref: EC:2.7.7.52 xref: GO:0050265 xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0007618 name: rosmarinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate." [EC:2.3.1.140, MetaCyc:ROSMARINATE-SYNTHASE-RXN] synonym: "4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity" EXACT [EC:2.3.1.140] synonym: "caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity" EXACT [EC:2.3.1.140] synonym: "caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity" EXACT [EC:2.3.1.140] synonym: "rosmarinic acid synthase activity" EXACT [EC:2.3.1.140] xref: EC:2.3.1.140 xref: GO:0050266 xref: MetaCyc:ROSMARINATE-SYNTHASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007619 name: rubber cis-polyprenylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit." [EC:2.5.1.20, MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN] synonym: "cis-prenyl transferase activity" EXACT [EC:2.5.1.20] synonym: "isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity" EXACT [EC:2.5.1.20] synonym: "poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber allyltransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber polymerase activity" EXACT [EC:2.5.1.20] synonym: "rubber prenyltransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber transferase activity" BROAD [EC:2.5.1.20] xref: EC:2.5.1.20 xref: GO:0050267 xref: MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007620 name: coniferyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH." [EC:1.1.1.194, MetaCyc:RXN-1107] synonym: "coniferyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.194] xref: EC:1.1.1.194 xref: GO:0050268 xref: MetaCyc:RXN-1107 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007621 name: coniferyl-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+." [EC:1.2.1.68, MetaCyc:RXN-1241] subset: gosubset_prok synonym: "coniferyl aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.68] xref: EC:1.2.1.68 xref: GO:0050269 xref: MetaCyc:RXN-1241 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007622 name: S-adenosylhomocysteine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = S-inosyl-L-homocysteine + NH3." [EC:3.5.4.28, MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN] synonym: "adenosylhomocysteine deaminase activity" EXACT [EC:3.5.4.28] synonym: "S-adenosyl-L-homocysteine aminohydrolase activity" EXACT [EC:3.5.4.28] xref: EC:3.5.4.28 xref: GO:0050270 xref: MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0007623 name: S-alkylcysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate." [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN] synonym: "alkyl cysteine lyase activity" EXACT [EC:4.4.1.6] synonym: "alkylcysteine lyase activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteinase activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine lyase activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.6] synonym: "S-alkylcysteinase activity" EXACT [EC:4.4.1.6] xref: EC:4.4.1.6 xref: GO:0050271 xref: MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0007624 name: S-carboxymethylcysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride." [EC:4.5.1.5, MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN] synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate)" EXACT [EC:4.5.1.5] synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)" EXACT [EC:4.5.1.5] synonym: "S-carboxymethyl-L-cysteine synthase activity" EXACT [EC:4.5.1.5] xref: EC:4.5.1.5 xref: GO:0050272 xref: MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN is_a: CCO:F0003412 ! carbon-halide lyase activity [Term] id: CCO:F0007625 name: S-succinylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + succinate." [EC:3.1.2.13, MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN] xref: EC:3.1.2.13 xref: GO:0050273 xref: MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN is_a: CCO:F0003361 ! thiolester hydrolase activity [Term] id: CCO:F0007626 name: salicyl-alcohol beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + salicyl alcohol = UDP + salicin." [EC:2.4.1.172, MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN] synonym: "salicyl-alcohol b-D-glucosyltransferase activity" EXACT [] synonym: "salicyl-alcohol glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172] synonym: "UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity" EXACT [EC:2.4.1.172] synonym: "UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172] synonym: "uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity" EXACT [EC:2.4.1.172] xref: EC:2.4.1.172 xref: GO:0050274 xref: MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007627 name: scopoletin glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + scopoletin = UDP + scopolin." [EC:2.4.1.128, MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN] synonym: "SGTase activity" EXACT [EC:2.4.1.128] synonym: "UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128] synonym: "UDPglucose:scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128] synonym: "UDPglucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128] synonym: "uridine diphosphoglucose-scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128] xref: EC:2.4.1.128 xref: GO:0050275 xref: MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007628 name: scyllo-inosamine 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-amino-1-deoxy-scyllo-inositol = ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate." [EC:2.7.1.65, MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN] synonym: "ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.65] synonym: "ATP:inosamine phosphotransferase activity" EXACT [EC:2.7.1.65] synonym: "scyllo-inosamine kinase (phosphorylating)" EXACT [EC:2.7.1.65] synonym: "scyllo-inosamine kinase activity" EXACT [] xref: EC:2.7.1.65 xref: GO:0050276 xref: MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007629 name: sedoheptulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate." [EC:2.7.1.14, MetaCyc:SEDOHEPTULOKINASE-RXN] synonym: "ATP:sedoheptulose 7-phosphotransferase activity" EXACT [EC:2.7.1.14] synonym: "heptulokinase activity" EXACT [EC:2.7.1.14] synonym: "sedoheptulokinase (phosphorylating)" EXACT [EC:2.7.1.14] xref: EC:2.7.1.14 xref: GO:0050277 xref: MetaCyc:SEDOHEPTULOKINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007630 name: sedoheptulose-bisphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate." [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN] subset: gosubset_prok synonym: "SBPase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose 1,7-bisphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose 1,7-diphospate phosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose 1,7-diphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose bisphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose diphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose-1,7-bisphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.37] xref: EC:3.1.3.37 xref: GO:0050278 xref: MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007631 name: sepiapterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN] synonym: "sepiapterin aminohydrolase activity" EXACT [EC:3.5.4.24] xref: EC:3.5.4.24 xref: GO:0050279 xref: MetaCyc:SEPIAPTERIN-DEAMINASE-RXN is_a: CCO:F0003383 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0007632 name: sequoyitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-O-methyl-myo-inositol + NAD+ = 5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH." [EC:1.1.1.143, MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN] synonym: "5-O-methyl-myo-inositol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.143] xref: EC:1.1.1.143 xref: GO:0050280 xref: MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007633 name: serine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine." [EC:2.6.1.45, MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN] subset: gosubset_prok synonym: "L-serine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.45] synonym: "serine--glyoxylate aminotransferase activity" EXACT [] synonym: "SGAT activity" EXACT [EC:2.6.1.45] xref: EC:2.6.1.45 xref: GO:0050281 xref: MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007634 name: serine 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH." [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN] synonym: "L-serine:NAD oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.7] synonym: "L-serine:NAD+ 2-oxidoreductase (deaminating)" EXACT [EC:1.4.1.7] synonym: "serine dehydrogenase activity" EXACT [] xref: EC:1.4.1.7 xref: GO:0050282 xref: MetaCyc:SERINE-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007635 name: serine-sulfate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + SO4(2-) (sulfate)." [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN] synonym: "(L-SOS)lyase activity" EXACT [EC:4.3.1.10] synonym: "L-serine-O-sulfate ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.10] synonym: "serine-sulphate ammonia-lyase activity" EXACT [] xref: EC:4.3.1.10 xref: GO:0050283 xref: MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN is_a: CCO:F0003406 ! ammonia-lyase activity [Term] id: CCO:F0007636 name: sinapate 1-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose." [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP-glucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "UDPglucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "UDPglucose:sinapic acid glucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "uridine diphosphoglucose-sinapate glucosyltransferase activity" EXACT [EC:2.4.1.120] xref: EC:2.4.1.120 xref: GO:0050284 xref: MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007637 name: sinapine esterase activity namespace: molecular_function def: "Catalysis of the reaction: sinapoylcholine + H2O = sinapate + choline." [EC:3.1.1.49, MetaCyc:SINAPINE-ESTERASE-RXN] synonym: "aromatic choline esterase activity" EXACT [EC:3.1.1.49] synonym: "sinapoylcholine sinapohydrolase activity" EXACT [EC:3.1.1.49] xref: EC:3.1.1.49 xref: GO:0050285 xref: MetaCyc:SINAPINE-ESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007638 name: sorbitol-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sorbitol 6-phosphate + H2O = sorbitol + phosphate." [EC:3.1.3.50, MetaCyc:SORBITOL-6-PHOSPHATASE-RXN] synonym: "sorbitol-6-phosphate phosphatase activity" EXACT [EC:3.1.3.50] synonym: "sorbitol-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.50] xref: EC:3.1.3.50 xref: GO:0050286 xref: MetaCyc:SORBITOL-6-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007639 name: sorbose 5-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.123, MetaCyc:SORBOSE-5-DEHYDROGENASE-(NADP+)-RXN] synonym: "5-keto-D-fructose reductase activity" EXACT [EC:1.1.1.123] synonym: "5-ketofructose reductase activity" EXACT [EC:1.1.1.123] synonym: "L-sorbose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.123] synonym: "reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity" EXACT [EC:1.1.1.123] synonym: "sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.123] xref: EC:1.1.1.123 xref: GO:0050287 xref: MetaCyc:SORBOSE-5-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007640 name: sorbose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-sorbose + acceptor = 5-dehydro-D-fructose + reduced acceptor." [EC:1.1.99.12, MetaCyc:SORBOSE-DEHYDROGENASE-RXN] synonym: "L-sorbose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.12] synonym: "L-sorbose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.12] xref: EC:1.1.99.12 xref: GO:0050288 xref: MetaCyc:SORBOSE-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007641 name: spermidine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor." [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN] synonym: "spermidine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.6] synonym: "spermidine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.6] xref: EC:1.5.99.6 xref: GO:0050289 xref: MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN is_a: CCO:F0003244 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: CCO:F0007642 name: sphingomyelin phosphodiesterase D activity namespace: molecular_function def: "Catalysis of the reaction: sphingomyelin + H2O = ceramide phosphate + choline." [EC:3.1.4.41, MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN] synonym: "sphingomyelin ceramide-phosphohydrolase activity" EXACT [EC:3.1.4.41] synonym: "sphingomyelinase D" RELATED [EC:3.1.4.41] xref: EC:3.1.4.41 xref: GO:0050290 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN is_a: CCO:F0000999 ! phospholipase activity is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0007643 name: sphingosine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae, either dihydrosphingosine (DHS) or phytosphingosine (PHS) can react with C26-fattyacyl-CoA to produce ceramide-I or ceramide-II (also called phytoceramide) respectively. In mammals, DHS is usually acylated with a C18 fatty acid group." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845] synonym: "acyl-CoA:sphingosine N-acyltransferase activity" EXACT [EC:2.3.1.24] synonym: "ceramide synthase activity" EXACT [] synonym: "ceramide synthetase activity" EXACT [EC:2.3.1.24] synonym: "dihydroceramide synthase activity" EXACT [] synonym: "sphingosine acyltransferase activity" EXACT [EC:2.3.1.24] xref: EC:2.3.1.24 xref: GO:0050291 xref: MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0007644 name: steroid 9-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pregna-4,9(11)-diene-3,20-dione + donor-H2 + O2 = 9,11-alpha-epoxypregn-4-ene-3,20-dione + acceptor + H2O." [EC:1.14.99.24, MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN] synonym: "steroid 9-alpha-hydroxylase activity" EXACT [EC:1.14.99.24] synonym: "steroid 9a-monooxygenase activity" EXACT [] synonym: "steroid 9alpha-hydroxylase activity" EXACT [EC:1.14.99.24] synonym: "steroid 9alpha-monooxygenase activity" EXACT [EC:1.14.99.24] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)" EXACT [EC:1.14.99.24] xref: EC:1.14.99.24 xref: GO:0050292 xref: MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007645 name: steroid-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: testololactone + H2O = testolate." [EC:3.1.1.37, MetaCyc:STEROID-LACTONASE-RXN] synonym: "testololactone lactonohydrolase activity" EXACT [EC:3.1.1.37] xref: EC:3.1.1.37 xref: GO:0050293 xref: MetaCyc:STEROID-LACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007646 name: steroid sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" EXACT [EC:2.8.2.15] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15] synonym: "steroid sulphotransferase activity" EXACT [] xref: EC:2.8.2.15 xref: GO:0050294 xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN xref: Reactome:80520 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007647 name: steryl-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + cholesteryl-beta-D-glucoside = D-glucose + cholesterol." [EC:3.2.1.104, MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN] synonym: "cholesteryl-beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.104] synonym: "steryl-b-glucosidase activity" EXACT [] xref: EC:3.2.1.104 xref: GO:0050295 xref: MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007648 name: stipitatonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: stipitatonate = stipitatate + CO2." [EC:4.1.1.60, MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN] synonym: "stipitatonate carboxy-lyase (decyclizing)" EXACT [EC:4.1.1.60] synonym: "stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)" EXACT [EC:4.1.1.60] xref: EC:4.1.1.60 xref: GO:0050296 xref: MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007649 name: stizolobate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN] synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.29] xref: EC:1.13.11.29 xref: GO:0050297 xref: MetaCyc:STIZOLOBATE-SYNTHASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007650 name: stizolobinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN] synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.30] xref: EC:1.13.11.30 xref: GO:0050298 xref: MetaCyc:STIZOLOBINATE-SYNTHASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007651 name: streptomycin 3''-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + streptomycin = ADP + streptomycin 3''-phosphate." [EC:2.7.1.87, MetaCyc:STREPTOMYCIN-3] subset: gosubset_prok synonym: "ATP:streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87] synonym: "streptomycin 3''-kinase (phosphorylating)" EXACT [EC:2.7.1.87] synonym: "streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87] xref: EC:2.7.1.87 xref: GO:0050299 xref: MetaCyc:STREPTOMYCIN-3 is_a: CCO:F0005515 ! aminoglycoside phosphotransferase activity [Term] id: CCO:F0007652 name: aminoglycoside 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + streptomycin = ADP + streptomycin 6-phosphate." [EC:2.7.1.72, MetaCyc:STREPTOMYCIN-6-KINASE-RXN] subset: gosubset_prok synonym: "APH(6) activity" EXACT [EC:2.7.1.72] synonym: "ATP:streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] synonym: "SM 6-kinase activity" NARROW [EC:2.7.1.72] synonym: "streptidine kinase (phosphorylating)" NARROW [EC:2.7.1.72] synonym: "streptidine kinase activity" NARROW [EC:2.7.1.72] synonym: "streptomycin 6-kinase (phosphorylating)" NARROW [EC:2.7.1.72] synonym: "streptomycin 6-kinase activity" NARROW [] synonym: "streptomycin 6-O-phosphotransferase activity" NARROW [EC:2.7.1.72] synonym: "streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] xref: EC:2.7.1.72 xref: GO:0050300 xref: MetaCyc:STREPTOMYCIN-6-KINASE-RXN is_a: CCO:F0005515 ! aminoglycoside phosphotransferase activity [Term] id: CCO:F0007653 name: streptomycin-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: streptomycin 6-phosphate + H2O = streptomycin + phosphate." [EC:3.1.3.39, MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN] subset: gosubset_prok synonym: "streptomycin 6-phosphate phosphatase activity" EXACT [EC:3.1.3.39] synonym: "streptomycin 6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39] synonym: "streptomycin-6-P phosphohydrolase activity" EXACT [EC:3.1.3.39] synonym: "streptomycin-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39] xref: EC:3.1.3.39 xref: GO:0050301 xref: MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007654 name: indole-3-acetaldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 2 indole acetaldehyde = 2 indole-3-acetic acid (IAA)." [EC:1.2.3.7, MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN] synonym: "(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7] synonym: "AO1" RELATED [EC:1.2.3.7] synonym: "IAA oxidase activity" EXACT [EC:1.2.3.7] synonym: "IAAld oxidase activity" EXACT [EC:1.2.3.7] synonym: "indole-3-acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7] synonym: "indoleacetaldehyde oxidase activity" EXACT [EC:1.2.3.7] xref: EC:1.2.3.7 xref: GO:0050302 xref: MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN is_a: CCO:F0003685 ! aryl-aldehyde oxidase activity [Term] id: CCO:F0007655 name: lysine 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN] synonym: "L-lysine 6-dehydrogenase activity" EXACT [EC:1.4.1.18] synonym: "L-lysine epsilon-dehydrogenase activity" EXACT [EC:1.4.1.18] synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" EXACT [EC:1.4.1.18] synonym: "LysDH activity" EXACT [EC:1.4.1.18] xref: EC:1.4.1.18 xref: GO:0050303 xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN xref: MetaCyc:PWY-5314 is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007656 name: nitrous-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrogen + H2O + acceptor = nitrous oxide + reduced acceptor." [EC:1.7.99.6, MetaCyc:NITROUS-OXIDE-REDUCTASE-RXN] subset: gosubset_prok synonym: "N2O reductase activity" EXACT [EC:1.7.99.6] synonym: "nitrogen:(acceptor) oxidoreductase (N2O-forming)" EXACT [EC:1.7.99.6] synonym: "nitrogen:acceptor oxidoreductase (N2O-forming)" EXACT [EC:1.7.99.6] synonym: "nitrous oxide reductase activity" EXACT [EC:1.7.99.6] xref: EC:1.7.99.6 xref: GO:0050304 xref: MetaCyc:NITROUS-OXIDE-REDUCTASE-RXN is_a: CCO:F0003256 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: CCO:F0007657 name: strombine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + NAD+ + H2O = glycine + pyruvate + NADH." [EC:1.5.1.22, MetaCyc:STROMBINE-DEHYDROGENASE-RXN] synonym: "N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity" EXACT [EC:1.5.1.22] synonym: "N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)" EXACT [EC:1.5.1.22] synonym: "strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity" EXACT [EC:1.5.1.22] xref: EC:1.5.1.22 xref: GO:0050305 xref: MetaCyc:STROMBINE-DEHYDROGENASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007658 name: sucrose 1F-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose." [EC:2.4.1.99, MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN] synonym: "SST activity" EXACT [EC:2.4.1.99] synonym: "sucrose 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose-sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1'-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose fructosyltransferase activity" EXACT [EC:2.4.1.99] xref: EC:2.4.1.99 xref: GO:0050306 xref: MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN is_a: CCO:F0008006 ! fructosyltransferase activity [Term] id: CCO:F0007659 name: sucrose-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate." [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN] subset: gosubset_prok synonym: "sucrose 6-phosphate hydrolase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-6-phosphatase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-6F-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-phosphate hydrolase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24] xref: EC:3.1.3.24 xref: GO:0050307 xref: MetaCyc:SUCROSE-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007660 name: sugar-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN] synonym: "sugar-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.23] xref: EC:3.1.3.23 xref: GO:0050308 xref: MetaCyc:SUGAR-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007661 name: sugar-terminal-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a sugar phosphate = a sugar + phosphate; an example is D-glucose 6-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN] synonym: "sugar-omega-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.58] synonym: "xylitol-5-phosphatase activity" EXACT [EC:3.1.3.58] xref: EC:3.1.3.58 xref: GO:0050309 xref: MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN is_a: CCO:F0004126 ! carbohydrate phosphatase activity [Term] id: CCO:F0007662 name: sulfite dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: SO3(2-) (sulfite) + 2 ferricytochrome c + H2O = SO4(2-) (sulfate) + 2 ferrocytochrome c." [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "sulfite cytochrome c reductase activity" EXACT [EC:1.8.2.1] synonym: "sulfite-cytochrome c oxidoreductase activity" EXACT [EC:1.8.2.1] synonym: "sulfite:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.1] synonym: "sulphite dehydrogenase activity" EXACT [] xref: EC:1.8.2.1 xref: GO:0050310 xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN is_a: CCO:F0003262 ! oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor [Term] id: CCO:F0007663 name: sulfite reductase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = SO3(2-) (sulfite) + 3 reduced ferredoxin." [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-(FERREDOXIN)-RXN] subset: gosubset_prok synonym: "ferredoxin-sulfite reductase activity" EXACT [EC:1.8.7.1] synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" EXACT [EC:1.8.7.1] synonym: "sulphite reductase (ferredoxin) activity" EXACT [] xref: EC:1.8.7.1 xref: GO:0050311 xref: MetaCyc:SULFITE-REDUCTASE-(FERREDOXIN)-RXN is_a: CCO:F0003266 ! oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0007664 name: sulfoacetaldehyde lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + SO3(2-) (sulfite)." [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN] comment: Note that EC:4.4.1.12 was deleted from EC as the reaction is performed by sulfoacetaldehyde acetyltransferase (EC:2.3.3.15). synonym: "sulphoacetaldehyde lyase activity" EXACT [] xref: EC:4.4.1.- xref: GO:0050312 xref: MetaCyc:SULFOACETALDEHYDE-LYASE-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0007665 name: sulfur dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfur + O2 + H2O = SO3(2-) (sulfite)." [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN] synonym: "S-sulfanylglutathione:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18] synonym: "sulfur oxygenase activity" EXACT [EC:1.13.11.18] synonym: "sulfur:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18] synonym: "sulphur dioxygenase activity" EXACT [] xref: EC:1.13.11.18 xref: GO:0050313 xref: MetaCyc:SULFUR-DIOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007666 name: sym-norspermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + propane-1,3-diamine = 5'-methylthioadenosine + bis(3-aminopropyl)amine." [EC:2.5.1.23, MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN] synonym: "S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.23] xref: EC:2.5.1.23 xref: GO:0050314 xref: MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007667 name: synephrine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-(methylamino)ethanol = (4-hydroxyphenyl)acetaldehyde + methylamine." [EC:4.2.1.88, MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN] synonym: "1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)" EXACT [EC:4.2.1.88] xref: EC:4.2.1.88 xref: GO:0050315 xref: MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007668 name: T2-induced deoxynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dGMP (or dTMP) = ADP + dGDP (or dTDP)." [EC:2.7.4.12, MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN] synonym: "ATP:(d)NMP phosphotransferase activity" EXACT [EC:2.7.4.12] xref: EC:2.7.4.12 xref: GO:0050316 xref: MetaCyc:GMKALT-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0007669 name: tagatose kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-tagatose = ADP + D-tagatose 6-phosphate." [EC:2.7.1.101, MetaCyc:TAGATOSE-KINASE-RXN] synonym: "ATP:D-tagatose 6-phosphotransferase activity" EXACT [EC:2.7.1.101] synonym: "D-tagatose 6-phosphate kinase activity" EXACT [EC:2.7.1.101] synonym: "tagatose 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.101] xref: EC:2.7.1.101 xref: GO:0050317 xref: MetaCyc:TAGATOSE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007670 name: tannase activity namespace: molecular_function def: "Catalysis of the reaction: digallate + H2O = 2 gallate." [EC:3.1.1.20, MetaCyc:TANNASE-RXN] synonym: "tannase S" RELATED [EC:3.1.1.20] synonym: "tannin acetylhydrolase activity" EXACT [EC:3.1.1.20] synonym: "tannin acylhydrolase activity" EXACT [EC:3.1.1.20] xref: EC:3.1.1.20 xref: GO:0050318 xref: MetaCyc:TANNASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007671 name: tartrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (R,R)-tartrate = D-glycerate + CO2." [EC:4.1.1.73, MetaCyc:TARTRATE-DECARBOXYLASE-RXN] synonym: "(R,R)-tartrate carboxy-lyase (D-glycerate-forming)" EXACT [EC:4.1.1.73] synonym: "(R,R)-tartrate carboxy-lyase activity" EXACT [EC:4.1.1.73] xref: EC:4.1.1.73 xref: GO:0050319 xref: MetaCyc:TARTRATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007672 name: tartrate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (R,R)-tartrate = meso-tartrate." [EC:5.1.2.5, MetaCyc:TARTRATE-EPIMERASE-RXN] synonym: "tartaric racemase activity" EXACT [EC:5.1.2.5] xref: EC:5.1.2.5 xref: GO:0050320 xref: MetaCyc:TARTRATE-EPIMERASE-RXN is_a: CCO:F0003419 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: CCO:F0007673 name: tau-protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN] synonym: "[Tau protein] kinase activity" EXACT [] synonym: "ATP:tau-protein O-phosphotransferase activity" BROAD [EC:2.7.11.26] synonym: "brain protein kinase PK40erk activity" NARROW [EC:2.7.11.26] synonym: "cdk5/p20" RELATED [EC:2.7.11.26] synonym: "CDK5/p23" RELATED [EC:2.7.11.26] synonym: "glycogen synthase kinase-3beta activity" EXACT [EC:2.7.11.26] synonym: "GSK" RELATED [EC:2.7.11.26] synonym: "protein tau kinase activity" EXACT [EC:2.7.11.26] synonym: "STK31" RELATED [EC:2.7.11.26] synonym: "tau kinase activity" EXACT [EC:2.7.11.26] synonym: "tau protein kinase activity" EXACT [EC:2.7.11.26] synonym: "tau-protein kinase I activity" NARROW [EC:2.7.11.26] synonym: "tau-protein kinase II activity" NARROW [EC:2.7.11.26] synonym: "tau-tubulin kinase activity" NARROW [EC:2.7.11.26] synonym: "TPK" RELATED [EC:2.7.11.26] synonym: "TPK I" RELATED [EC:2.7.11.26] synonym: "TPK II" RELATED [EC:2.7.11.26] synonym: "TTK" RELATED [EC:2.7.11.26] xref: EC:2.7.11.26 xref: GO:0050321 xref: MetaCyc:TAU-PROTEIN-KINASE-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0007674 name: taurine-2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate." [EC:2.6.1.55, MetaCyc:TAURINE-AMINOTRANSFERASE-RXN] synonym: "taurine aminotransferase activity" EXACT [] synonym: "taurine transaminase activity" EXACT [] synonym: "taurine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.55] synonym: "taurine--glutamate transaminase activity" EXACT [EC:2.6.1.55] synonym: "taurine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.55] xref: EC:2.6.1.55 xref: GO:0050322 xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007675 name: taurine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: taurine + H2O + acceptor = sulfoacetaldehyde + NH3 + reduced acceptor." [EC:1.4.99.2, MetaCyc:TAURINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "taurine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.2] synonym: "taurine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.2] xref: EC:1.4.99.2 xref: GO:0050323 xref: MetaCyc:TAURINE-DEHYDROGENASE-RXN is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0007676 name: taurocyamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + taurocyamine = ADP + N-phosphotaurocyamine." [EC:2.7.3.4, MetaCyc:TAUROCYAMINE-KINASE-RXN] synonym: "ATP:taurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.4] synonym: "ATP:taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4] synonym: "taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4] xref: EC:2.7.3.4 xref: GO:0050324 xref: MetaCyc:TAUROCYAMINE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003347 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: CCO:F0007677 name: tauropine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: tauropine + NAD+ + H2O = taurine + pyruvate + NADH." [EC:1.5.1.23, MetaCyc:TAUROPINE-DEHYDROGENASE-RXN] synonym: "2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23] synonym: "N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23] xref: EC:1.5.1.23 xref: GO:0050325 xref: MetaCyc:TAUROPINE-DEHYDROGENASE-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007678 name: taxifolin 8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O." [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN] synonym: "taxifolin hydroxylase activity" EXACT [] synonym: "taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.19] xref: EC:1.14.13.19 xref: GO:0050326 xref: MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007679 name: testosterone 17-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH." [EC:1.1.1.63, MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN] synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.63] synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.63] synonym: "17beta-HSD" RELATED [EC:1.1.1.63] synonym: "17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity" EXACT [EC:1.1.1.63] synonym: "testosterone 17b-dehydrogenase activity" EXACT [] synonym: "testosterone 17beta-dehydrogenase activity" EXACT [EC:1.1.1.63] xref: EC:1.1.1.63 xref: GO:0050327 xref: MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN is_a: CCO:F0005254 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007680 name: tetrahydroberberine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2." [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN] synonym: "(S)-tetrahydroberberine:oxygen oxidoreductase activity" EXACT [EC:1.3.3.8] synonym: "(S)-THB oxidase activity" EXACT [EC:1.3.3.8] synonym: "THB oxidase activity" EXACT [EC:1.3.3.8] xref: EC:1.3.3.8 xref: GO:0050328 xref: MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0007681 name: tetrahydroxypteridine cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydroxypteridine = xanthine-8-carboxylate." [EC:5.5.1.3, MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN] synonym: "tetrahydroxypteridine lyase (isomerizing)" EXACT [EC:5.5.1.3] xref: EC:5.5.1.3 xref: GO:0050329 xref: MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0007682 name: theanine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine." [EC:3.5.1.65, MetaCyc:THEANINE-HYDROLASE-RXN] synonym: "5-N-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65] synonym: "L-theanine amidohydrolase activity" EXACT [EC:3.5.1.65] synonym: "N5-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65] xref: EC:3.5.1.65 xref: GO:0050330 xref: MetaCyc:THEANINE-HYDROLASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007683 name: thiamin diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate." [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN] synonym: "ATP:thiamin-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] synonym: "ATP:thiamine-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] synonym: "protein bound thiamin diphosphate:ATP phosphoryltransferase activity" EXACT [EC:2.7.4.15] synonym: "TDP kinase activity" EXACT [EC:2.7.4.15] synonym: "thiamin diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] synonym: "thiamin pyrophosphate kinase activity" EXACT [EC:2.7.4.15] synonym: "thiamin-diphosphate kinase activity" EXACT [] synonym: "thiamine diphosphate kinase activity" EXACT [EC:2.7.4.15] synonym: "thiamine-diphosphate kinase activity" EXACT [] xref: EC:2.7.4.15 xref: GO:0050331 xref: MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0007684 name: thiamin pyridinylase activity namespace: molecular_function def: "Catalysis of the reaction: thiamin + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole." [EC:2.5.1.2, MetaCyc:THIAMIN-PYRIDINYLASE-RXN] subset: gosubset_prok synonym: "pyrimidine transferase activity" EXACT [EC:2.5.1.2] synonym: "thiamin hydrolase activity" EXACT [EC:2.5.1.2] synonym: "thiamin pyridinolase activity" EXACT [EC:2.5.1.2] synonym: "thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2] synonym: "thiaminase I activity" NARROW [EC:2.5.1.2] synonym: "thiamine hydrolase activity" EXACT [EC:2.5.1.2] synonym: "thiamine pyridinolase activity" EXACT [EC:2.5.1.2] synonym: "thiamine pyridinylase activity" EXACT [] synonym: "thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2] xref: EC:2.5.1.2 xref: GO:0050332 xref: MetaCyc:THIAMIN-PYRIDINYLASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007685 name: thiamin-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: thiamin triphosphate + H2O = thiamin diphosphate + phosphate." [EC:3.6.1.28, MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN] synonym: "thiamine-triphosphatase activity" EXACT [] synonym: "thiamine-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.28] synonym: "ThTPase activity" EXACT [EC:3.6.1.28] xref: EC:3.6.1.28 xref: GO:0048253 xref: GO:0050333 xref: MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN is_a: CCO:F0003574 ! nucleoside-triphosphatase activity [Term] id: CCO:F0007686 name: thiaminase activity namespace: molecular_function def: "Catalysis of the reaction: thiamin + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole." [EC:3.5.99.2, MetaCyc:THIAMINASE-RXN] synonym: "thiaminase II activity" NARROW [EC:3.5.99.2] xref: EC:3.5.99.2 xref: GO:0050334 xref: MetaCyc:THIAMINASE-RXN is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: CCO:F0007687 name: thiocyanate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate." [EC:5.99.1.1, MetaCyc:THIOCYANATE-ISOMERASE-RXN] synonym: "benzyl-thiocyanate isomerase activity" EXACT [EC:5.99.1.1] synonym: "isothiocyanate isomerase activity" EXACT [EC:5.99.1.1] xref: EC:5.99.1.1 xref: GO:0050335 xref: MetaCyc:THIOCYANATE-ISOMERASE-RXN is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0007688 name: thioethanolamine S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + thioethanolamine = CoA + S-acetylthioethanolamine." [EC:2.3.1.11, MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity" EXACT [EC:2.3.1.11] synonym: "acetyl-CoA:thioethanolamine S-acetyltransferase activity" EXACT [EC:2.3.1.11] synonym: "thioethanolamine acetyltransferase activity" EXACT [EC:2.3.1.11] synonym: "thioltransacetylase B activity" EXACT [EC:2.3.1.11] xref: EC:2.3.1.11 xref: GO:0050336 xref: MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN is_a: CCO:F0003141 ! S-acetyltransferase activity [Term] id: CCO:F0007689 name: thiosulfate-thiol sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: thiosulfate + 2 glutathione = SO3(2-) (sulfite) + glutathione disulfide + sulfide." [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN] synonym: "glutathione-dependent thiosulfate reductase activity" EXACT [EC:2.8.1.3] synonym: "sulfane reductase activity" EXACT [EC:2.8.1.3] synonym: "sulfane sulfurtransferase activity" EXACT [EC:2.8.1.3] synonym: "thiosulfate:thiol sulfurtransferase activity" EXACT [EC:2.8.1.3] synonym: "thiosulphate-thiol sulphurtransferase activity" EXACT [] xref: EC:2.8.1.3 xref: GO:0050337 xref: MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN is_a: CCO:F0003355 ! sulfurtransferase activity [Term] id: CCO:F0007690 name: thiosulfate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c." [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN] synonym: "tetrathionate synthase activity" EXACT [EC:1.8.2.2] synonym: "thiosulfate oxidase activity" EXACT [EC:1.8.2.2] synonym: "thiosulfate-acceptor oxidoreductase activity" EXACT [EC:1.8.2.2] synonym: "thiosulfate-oxidizing enzyme" RELATED [EC:1.8.2.2] synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.2] synonym: "thiosulphate dehydrogenase activity" EXACT [] xref: EC:1.8.2.2 xref: GO:0050338 xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN is_a: CCO:F0003262 ! oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor [Term] id: CCO:F0007691 name: thymidine-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + H2O = dTDP + phosphate." [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN] synonym: "deoxythymidine-5'-triphosphatase activity" EXACT [EC:3.6.1.39] synonym: "dTTP nucleotidohydrolase activity" EXACT [EC:3.6.1.39] synonym: "dTTPase activity" EXACT [EC:3.6.1.39] synonym: "thymidine triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.39] xref: EC:3.6.1.39 xref: GO:0050339 xref: MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN is_a: CCO:F0003574 ! nucleoside-triphosphatase activity [Term] id: CCO:F0007692 name: thymidylate 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate." [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5] synonym: "deoxythymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35] synonym: "deoxythymidylate phosphohydrolase activity" EXACT [EC:3.1.3.35] synonym: "deoxythymidylic 5'-nucleotidase activity" EXACT [EC:3.1.3.35] synonym: "dTMPase activity" EXACT [EC:3.1.3.35] synonym: "thymidylate 5' phosphatase activity" EXACT [] synonym: "thymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35] synonym: "thymidylate 5'-phosphohydrolase activity" EXACT [EC:3.1.3.35] synonym: "thymidylate nucleotidase activity" EXACT [EC:3.1.3.35] xref: EC:3.1.3.35 xref: GO:0050340 xref: MetaCyc:THYMIDYLATE-5 is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007693 name: thymine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2." [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN] synonym: "5-hydroxy-methyluracil dioxygenase activity" EXACT [EC:1.14.11.6] synonym: "5-hydroxymethyluracil oxygenase activity" EXACT [EC:1.14.11.6] synonym: "thymine 7-hydroxylase activity" EXACT [EC:1.14.11.6] synonym: "thymine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.6] synonym: "thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.11.6] xref: EC:1.14.11.6 xref: GO:0050341 xref: MetaCyc:THYMINE-DIOXYGENASE-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0007694 name: tocopherol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol." [EC:2.1.1.95, MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN] synonym: "gamma-tocopherol methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity" EXACT [EC:2.1.1.95] xref: EC:2.1.1.95 xref: GO:0050342 xref: MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN is_a: CCO:F0001758 ! O-methyltransferase activity [Term] id: CCO:F0007695 name: trans-2-enoyl-CoA reductase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH." [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-(NAD+)-RXN] synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.44] xref: EC:1.3.1.44 xref: GO:0050343 xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-(NAD+)-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007696 name: trans-cinnamate 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamate + NADPH + O2 = 2-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.14, MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN] synonym: "cinnamate 2-hydroxylase activity" EXACT [EC:1.14.13.14] synonym: "cinnamate 2-monooxygenase activity" EXACT [EC:1.14.13.14] synonym: "cinnamic 2-hydroxylase activity" EXACT [EC:1.14.13.14] synonym: "cinnamic acid 2-hydroxylase activity" EXACT [EC:1.14.13.14] synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.14] synonym: "trans-cinnamic acid 2-hydroxylase activity" EXACT [] xref: EC:1.14.13.14 xref: GO:0050344 xref: MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007697 name: trans-epoxysuccinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + trans-2,3-epoxysuccinate = meso-tartrate." [EC:3.3.2.4, MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN] synonym: "tartrate epoxydase activity" EXACT [EC:3.3.2.4] synonym: "trans-2,3-epoxysuccinate hydrolase activity" EXACT [EC:3.3.2.4] synonym: "trans-epoxysuccinate hydratase activity" EXACT [EC:3.3.2.4] xref: EC:3.3.2.4 xref: GO:0050345 xref: MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN is_a: CCO:F0003373 ! ether hydrolase activity [Term] id: CCO:F0007698 name: trans-L-3-hydroxyproline dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-L-3-hydroxyproline = H2O + delta(1)-pyrroline_2-carboxylate." [EC:4.2.1.77, MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN] synonym: "trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)" EXACT [EC:4.2.1.77] synonym: "trans-L-3-hydroxyproline hydro-lyase activity" EXACT [EC:4.2.1.77] xref: EC:4.2.1.77 xref: GO:0050346 xref: MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007699 name: trans-octaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-nonaprenyl diphosphate." [EC:2.5.1.11, MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN] synonym: "(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity" EXACT [EC:2.5.1.11] synonym: "all-trans-nonaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.11] synonym: "nonaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "polyprenylpyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "solanesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "solanesyl-diphosphate synthase activity" EXACT [EC:2.5.1.11] synonym: "SPP synthase activity" EXACT [EC:2.5.1.11] synonym: "terpenoidallyltransferase activity" EXACT [EC:2.5.1.11] synonym: "terpenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "trans-prenyltransferase activity" EXACT [EC:2.5.1.11] xref: EC:2.5.1.11 xref: GO:0050347 xref: MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007700 name: trehalose O-mycolyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate." [EC:2.3.1.122, MetaCyc:TREHALOSE-O-MYCOLYLTRANSFERASE-RXN] subset: gosubset_prok synonym: "alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity" EXACT [EC:2.3.1.122] synonym: "alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity" EXACT [EC:2.3.1.122] xref: EC:2.3.1.122 xref: GO:0050348 xref: MetaCyc:TREHALOSE-O-MYCOLYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007701 name: triacetate-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: triacetate lactone + H2O = triacetate." [EC:3.1.1.38, MetaCyc:TRIACETATE-LACTONASE-RXN] synonym: "TAL hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetate lactone hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetic acid lactone hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetic lactone hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetolactone lactonohydrolase activity" EXACT [EC:3.1.1.38] xref: EC:3.1.1.38 xref: GO:0050349 xref: MetaCyc:TRIACETATE-LACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007702 name: trihydroxystilbene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2." [EC:2.3.1.95, MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.95] synonym: "resveratrol synthase activity" EXACT [EC:2.3.1.95] synonym: "stilbene synthase activity" BROAD [EC:2.3.1.95] xref: EC:2.3.1.95 xref: GO:0050350 xref: MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007703 name: trimetaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: trimetaphosphate + H2O = triphosphate." [EC:3.6.1.2, MetaCyc:TRIMETAPHOSPHATASE-RXN] subset: gosubset_prok synonym: "inorganic trimetaphosphatase activity" EXACT [EC:3.6.1.2] synonym: "trimetaphosphate hydrolase activity" EXACT [EC:3.6.1.2] xref: EC:3.6.1.2 xref: GO:0050351 xref: MetaCyc:TRIMETAPHOSPHATASE-RXN is_a: CCO:F0003386 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: CCO:F0007704 name: trimethylamine-oxide aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (CH3)3NO = (CH3)2NH + formaldehyde." [EC:4.1.2.32, MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN] synonym: "trimethylamine N-oxide aldolase activity" EXACT [EC:4.1.2.32] synonym: "trimethylamine N-oxide demethylase activity" EXACT [EC:4.1.2.32] synonym: "trimethylamine N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32] synonym: "trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)" EXACT [EC:4.1.2.32] synonym: "trimethylamine-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32] xref: EC:4.1.2.32 xref: GO:0050352 xref: MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007705 name: trimethyllysine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2." [EC:1.14.11.8, MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN] synonym: "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8] synonym: "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8] synonym: "TML dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "TML hydroxylase activity" EXACT [EC:1.14.11.8] synonym: "TML-alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "TMLD activity" EXACT [EC:1.14.11.8] synonym: "trimethyllysine alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "trimethyllysine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] xref: EC:1.14.11.8 xref: GO:0050353 xref: MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0007706 name: triokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate." [EC:2.7.1.28, MetaCyc:TRIOKINASE-RXN] synonym: "ATP:D-glyceraldehyde 3-phosphotransferase activity" EXACT [EC:2.7.1.28] synonym: "D-triokinase activity" EXACT [EC:2.7.1.28] synonym: "trio triose kinase (phosphorylating)" EXACT [EC:2.7.1.28] synonym: "triose kinase activity" EXACT [EC:2.7.1.28] xref: EC:2.7.1.28 xref: GO:0050354 xref: MetaCyc:TRIOKINASE-RXN xref: Reactome:70343 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007707 name: triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: triphosphate + H2O = diphosphate + phosphate." [EC:3.6.1.25, MetaCyc:TRIPHOSPHATASE-RXN] subset: gosubset_prok synonym: "inorganic triphosphatase activity" EXACT [EC:3.6.1.25] synonym: "triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.25] xref: EC:3.6.1.25 xref: GO:0050355 xref: MetaCyc:TRIPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0007708 name: tropine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: tropine + NADP+ = tropinone + NADPH." [EC:1.1.1.206, MetaCyc:TROPINE-DEHYDROGENASE-RXN] synonym: "tropine:NADP+ 3alpha-oxidoreductase activity" EXACT [EC:1.1.1.206] xref: EC:1.1.1.206 xref: GO:0050356 xref: MetaCyc:TROPINE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007709 name: tropinesterase activity namespace: molecular_function def: "Catalysis of the reaction: atropine + H2O = tropine + tropate." [EC:3.1.1.10, MetaCyc:TROPINESTERASE-RXN] subset: gosubset_prok synonym: "atropinase activity" EXACT [EC:3.1.1.10] synonym: "atropine acylhydrolase activity" EXACT [EC:3.1.1.10] synonym: "atropine esterase activity" EXACT [EC:3.1.1.10] synonym: "atropinesterase activity" EXACT [EC:3.1.1.10] synonym: "tropine esterase activity" EXACT [EC:3.1.1.10] xref: EC:3.1.1.10 xref: GO:0050357 xref: MetaCyc:TROPINESTERASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007710 name: tropinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: pseudotropine + NADP+ = tropinone + NADPH." [EC:1.1.1.236, MetaCyc:TROPINONE-REDUCTASE-RXN] synonym: "pseudotropine forming tropinone reductase activity" EXACT [EC:1.1.1.236] synonym: "pseudotropine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.236] synonym: "tropinone (psi-tropine-forming) reductase activity" EXACT [EC:1.1.1.236] synonym: "tropinone reductase II activity" RELATED [EC:1.1.1.236] xref: EC:1.1.1.236 xref: GO:0050358 xref: MetaCyc:TROPINONE-REDUCTASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007711 name: tropomyosin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin." [EC:2.7.11.28, MetaCyc:TROPOMYOSIN-KINASE-RXN] synonym: "ATP:tropomyosin O-phosphotransferase activity" EXACT [EC:2.7.11.28] synonym: "STK" RELATED [EC:2.7.11.28] synonym: "tropomyosin kinase (phosphorylating) activity" EXACT [EC:2.7.11.28] xref: EC:2.7.11.28 xref: GO:0050359 xref: MetaCyc:TROPOMYOSIN-KINASE-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0007712 name: tryptophan 2'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3." [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2] synonym: "indole-3-alkane alpha-hydroxylase activity" EXACT [EC:1.13.99.3] synonym: "indolyl-3-alkan alpha-hydroxylase activity" EXACT [EC:1.13.99.3] synonym: "L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)" EXACT [EC:1.13.99.3] synonym: "tryptophan side chain oxidase activity" EXACT [EC:1.13.99.3] synonym: "tryptophan side chain oxidase II" RELATED [EC:1.13.99.3] synonym: "tryptophan side chain oxidase type I" RELATED [EC:1.13.99.3] synonym: "tryptophan side-chain alpha,beta-oxidase activity" RELATED [EC:1.13.99.3] synonym: "tryptophan side-chain oxidase activity" RELATED [EC:1.13.99.3] synonym: "TSO activity" RELATED [EC:1.13.99.3] synonym: "TSO I" RELATED [EC:1.13.99.3] synonym: "TSO II" RELATED [EC:1.13.99.3] xref: EC:1.13.99.3 xref: GO:0050360 xref: MetaCyc:TRYPTOPHAN-2 is_a: CCO:F0003285 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: CCO:F0007713 name: tryptophan 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O2 = indole-3-acetamide + CO2 + H2O." [EC:1.13.12.3, MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN] subset: gosubset_prok synonym: "L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.3] xref: EC:1.13.12.3 xref: GO:0050361 xref: MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: CCO:F0007714 name: tryptophan transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate." [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN] synonym: "5-hydroxytryptophan-ketoglutaric transaminase activity" EXACT [EC:2.6.1.27] synonym: "hydroxytryptophan aminotransferase activity" EXACT [EC:2.6.1.27] synonym: "L-phenylalanine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.27] synonym: "L-tryptophan aminotransferase activity" EXACT [EC:2.6.1.27] synonym: "L-tryptophan transaminase activity" EXACT [EC:2.6.1.27] synonym: "L-tryptophan:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.27] synonym: "tryptophan aminotransferase activity" EXACT [] xref: EC:2.6.1.27 xref: GO:0050362 xref: MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0007715 name: tryptophan dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+." [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN] synonym: "L-Trp-dehydrogenase activity" EXACT [EC:1.4.1.19] synonym: "L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19] synonym: "L-tryptophan:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.19] synonym: "NAD(P)+-L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19] synonym: "TDH" RELATED [EC:1.4.1.19] synonym: "TrpDH activity" EXACT [EC:1.4.1.19] xref: EC:1.4.1.19 xref: GO:0050363 xref: MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007716 name: tryptophan dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan." [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN] synonym: "4-(gamma,gamma-dimethylallyl)tryptophan synthase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallyltryptophan synthetase activity" EXACT [EC:2.5.1.34] synonym: "DMAT synthetase activity" EXACT [EC:2.5.1.34] xref: EC:2.5.1.34 xref: GO:0050364 xref: MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007717 name: tryptophanamidase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH3." [EC:3.5.1.57, MetaCyc:TRYPTOPHANAMIDASE-RXN] synonym: "L-tryptophan aminopeptidase" BROAD [EC:3.5.1.57] synonym: "L-tryptophanamide amidohydrolase activity" EXACT [EC:3.5.1.57] synonym: "tryptophan aminopeptidase" BROAD [EC:3.5.1.57] xref: EC:3.5.1.57 xref: GO:0050365 xref: MetaCyc:TRYPTOPHANAMIDASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007718 name: tyramine N-feruloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine." [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN] synonym: "feruloyl-CoA tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110] synonym: "feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.110] synonym: "feruloyltyramine synthase activity" EXACT [EC:2.3.1.110] synonym: "tyramine feruloyltransferase activity" EXACT [EC:2.3.1.110] synonym: "tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110] xref: EC:2.3.1.110 xref: GO:0050366 xref: MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007719 name: tyrosine-arginine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-tyrosine + L-arginine = AMP + diphosphate + L-tyrosyl-L-arginine." [EC:6.3.2.24, MetaCyc:TYROSINE--ARGININE-LIGASE-RXN] synonym: "kyotorphin synthase activity" EXACT [EC:6.3.2.24] synonym: "kyotorphin synthetase activity" EXACT [EC:6.3.2.24] synonym: "kyotorphin-synthesizing enzyme activity" EXACT [EC:6.3.2.24] synonym: "L-tyrosine:L-arginine ligase (AMP-forming)" EXACT [EC:6.3.2.24] synonym: "tyrosyl-arginine synthase activity" EXACT [EC:6.3.2.24] xref: EC:6.3.2.24 xref: GO:0050367 xref: MetaCyc:TYROSINE--ARGININE-LIGASE-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0007720 name: tyrosine 2,3-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate." [EC:5.4.3.6, MetaCyc:TYROSINE-2] synonym: "L-tyrosine 2,3-aminomutase activity" EXACT [EC:5.4.3.6] synonym: "tyrosine alpha,beta-mutase activity" EXACT [EC:5.4.3.6] xref: EC:5.4.3.6 xref: GO:0050368 xref: MetaCyc:TYROSINE-2 is_a: CCO:F0003430 ! intramolecular transferase activity, transferring amino groups [Term] id: CCO:F0007722 name: tyrosine N-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O." [EC:1.14.13.41, MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN] synonym: "CYP79A1 activity" NARROW [EC:1.14.13.41] synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT [EC:1.14.13.41] synonym: "tyrosine N-hydroxylase activity" EXACT [] xref: EC:1.14.13.41 xref: GO:0050370 xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007723 name: tyrosine phenol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + H2O = phenol + pyruvate + NH3." [EC:4.1.99.2, MetaCyc:TYROSINE-PHENOL-LYASE-RXN] subset: gosubset_prok synonym: "beta-tyrosinase activity" EXACT [EC:4.1.99.2] synonym: "L-tyrosine phenol-lyase (deaminating)" EXACT [EC:4.1.99.2] synonym: "L-tyrosine phenol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.1.99.2] xref: EC:4.1.99.2 xref: GO:0050371 xref: MetaCyc:TYROSINE-PHENOL-LYASE-RXN is_a: CCO:F0003397 ! carbon-carbon lyase activity [Term] id: CCO:F0007724 name: ubiquitin-calmodulin ligase activity namespace: molecular_function def: "Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin." [EC:6.3.2.21, MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN] synonym: "calmodulin:ubiquitin ligase (AMP-forming)" EXACT [EC:6.3.2.21] synonym: "ubiquitin-calmodulin synthetase activity" EXACT [EC:6.3.2.21] synonym: "ubiquityl-calmodulin synthase activity" EXACT [EC:6.3.2.21] synonym: "ubiquityl-calmodulin synthetase activity" EXACT [EC:6.3.2.21] synonym: "uCaM-synthetase activity" EXACT [EC:6.3.2.21] xref: EC:6.3.2.21 xref: GO:0050372 xref: MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN is_a: CCO:F0001198 ! ubiquitin-protein ligase activity [Term] id: CCO:F0007725 name: UDP-arabinose 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-L-arabinose = UDP-D-xylose." [EC:5.1.3.5, MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN] synonym: "UDP arabinose epimerase activity" EXACT [EC:5.1.3.5] synonym: "UDP-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "UDP-D-xylose-4-epimerase activity" EXACT [] synonym: "UDP-L-arabinose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "UDParabinose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "uridine 5'-diphosphate-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "uridine diphosphoarabinose epimerase activity" EXACT [EC:5.1.3.5] xref: EC:5.1.3.5 xref: GO:0050373 xref: MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007726 name: UDP-galacturonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galacturonate = UDP-L-arabinose + CO2." [EC:4.1.1.67, MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN] synonym: "UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)" EXACT [EC:4.1.1.67] synonym: "UDP-D-galacturonate carboxy-lyase activity" EXACT [EC:4.1.1.67] synonym: "UDP-galacturonic acid decarboxylase activity" EXACT [EC:4.1.1.67] synonym: "UDPgalacturonate decarboxylase activity" EXACT [EC:4.1.1.67] synonym: "UDPGalUA carboxy lyase activity" EXACT [EC:4.1.1.67] xref: EC:4.1.1.67 xref: GO:0050374 xref: MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007727 name: UDP-glucosamine 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucosamine = UDPgalactosamine." [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN] synonym: "UDP-glucosamine epimerase activity" EXACT [] synonym: "UDPglucosamine 4-epimerase activity" EXACT [EC:5.1.3.16] xref: EC:5.1.3.16 xref: GO:0050376 xref: MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007728 name: UDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose = UDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.76, MetaCyc:UDP-GLUCOSE-4] synonym: "UDP-D-glucose oxidoreductase activity" EXACT [EC:4.2.1.76] synonym: "UDP-D-glucose-4,6-hydrolyase activity" EXACT [EC:4.2.1.76] synonym: "UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.76] synonym: "UDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76] synonym: "UDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.76] synonym: "UDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76] xref: EC:4.2.1.76 xref: GO:0050377 xref: MetaCyc:UDP-GLUCOSE-4 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007729 name: UDP-glucuronate 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate = UDP-D-galacturonate." [EC:5.1.3.6, MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN] synonym: "UDP glucuronic epimerase activity" EXACT [EC:5.1.3.6] synonym: "UDP-D-galacturonic acid 4-epimerase activity" EXACT [EC:5.1.3.6] synonym: "UDP-galacturonate 4-epimerase activity" EXACT [EC:5.1.3.6] synonym: "UDPglucuronate 4-epimerase activity" EXACT [EC:5.1.3.6] synonym: "uridine diphospho-D-galacturonic acid" RELATED [EC:5.1.3.6] synonym: "uridine diphosphoglucuronate epimerase activity" EXACT [EC:5.1.3.6] synonym: "uridine diphosphoglucuronic epimerase activity" EXACT [EC:5.1.3.6] xref: EC:5.1.3.6 xref: GO:0050378 xref: MetaCyc:PWY-4861 xref: MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007730 name: UDP-glucuronate 5'-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate = UDP-L-iduronate." [EC:5.1.3.12, MetaCyc:UDP-GLUCURONATE-5] subset: gosubset_prok synonym: "C-5-uronosyl epimerase activity" EXACT [EC:5.1.3.12] synonym: "UDP-glucuronate 5' epimerase activity" EXACT [] synonym: "UDP-glucuronic acid 5'-epimerase activity" EXACT [EC:5.1.3.12] synonym: "UDP-glucuronic acid epimerase activity" EXACT [EC:5.1.3.12] synonym: "UDPglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12] synonym: "uridine diphosphoglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12] xref: EC:5.1.3.12 xref: GO:0050379 xref: MetaCyc:UDP-GLUCURONATE-5 is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007731 name: undecaprenyl-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate." [EC:3.6.1.27, MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN] subset: gosubset_prok synonym: "C(55)-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27] synonym: "C(55)-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] synonym: "C55-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27] synonym: "C55-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] synonym: "isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] synonym: "undecaprenyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.27] xref: EC:3.6.1.27 xref: GO:0050380 xref: MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0007732 name: unspecific monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O." [EC:1.14.14.1] subset: gosubset_prok synonym: "aromatase activity" EXACT [] synonym: "aryl hydrocarbon hydroxylase activity" EXACT [EC:1.14.14.1] synonym: "aryl-4-monooxygenase activity" EXACT [EC:1.14.14.1] synonym: "cytochrome p450 activity" NARROW [EC:1.14.14.1] synonym: "cytochrome P450 CYP19" NARROW [] synonym: "estrogen synthetase activity" NARROW [] synonym: "flavoprotein monooxygenase activity" EXACT [EC:1.14.14.1] synonym: "flavoprotein-linked monooxygenase activity" EXACT [EC:1.14.14.1] synonym: "microsomal monooxygenase activity" NARROW [EC:1.14.14.1] synonym: "microsomal P-450" RELATED [EC:1.14.14.1] synonym: "microsomal p450 activity" NARROW [EC:1.14.14.1] synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" EXACT [EC:1.14.14.1] synonym: "xenobiotic monooxygenase activity" RELATED [EC:1.14.14.1] xref: EC:1.14.14.1 xref: GO:0008402 xref: GO:0050381 xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN is_a: CCO:F0003295 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007733 name: uracil-5-carboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: uracil 5-carboxylate = uracil + CO2." [EC:4.1.1.66, MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN] synonym: "uracil-5-carboxylate carboxy-lyase (uracil-forming)" EXACT [EC:4.1.1.66] synonym: "uracil-5-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.66] synonym: "uracil-5-carboxylic acid decarboxylase activity" EXACT [EC:4.1.1.66] xref: EC:4.1.1.66 xref: GO:0050382 xref: MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007734 name: uracil dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [EC:1.1.99.19, MetaCyc:URACIL-DEHYDROGENASE-RXN] xref: EC:1.1.99.19 xref: GO:0050383 xref: MetaCyc:URACIL-DEHYDROGENASE-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0007735 name: urate-ribonucleotide phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: urate D-ribonucleotide + phosphate = urate + D-ribose 1-phosphate." [EC:2.4.2.16, MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN] synonym: "UAR phosphorylase activity" EXACT [EC:2.4.2.16] synonym: "urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.16] synonym: "urate-ribonucleotide:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.16] xref: EC:2.4.2.16 xref: GO:0050384 xref: MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0007736 name: ureidoglycolate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea." [EC:4.3.2.3, MetaCyc:UREIDOGLYCOLATE-LYASE-RXN] synonym: "(S)-ureidoglycolate urea-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.3] synonym: "(S)-ureidoglycolate urea-lyase activity" EXACT [EC:4.3.2.3] synonym: "ureidoglycolase activity" RELATED [EC:4.3.2.3] synonym: "ureidoglycolatase activity" RELATED [EC:4.3.2.3] xref: EC:4.3.2.3 xref: GO:0050385 xref: MetaCyc:UREIDOGLYCOLATE-LYASE-RXN is_a: CCO:F0003407 ! amidine-lyase activity [Term] id: CCO:F0007737 name: ureidosuccinase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O = L-aspartate + CO2 + NH3." [EC:3.5.1.7, MetaCyc:UREIDOSUCCINASE-RXN] synonym: "N-carbamoyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.7] xref: EC:3.5.1.7 xref: GO:0050386 xref: MetaCyc:UREIDOSUCCINASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007738 name: urethanase activity namespace: molecular_function def: "Catalysis of the reaction: urethane + H2O = ethanol + CO2 + NH3." [EC:3.5.1.75, MetaCyc:URETHANASE-RXN] synonym: "urethane amidohydrolase (decarboxylating)" EXACT [EC:3.5.1.75] synonym: "urethane hydrolase activity" EXACT [EC:3.5.1.75] xref: EC:3.5.1.75 xref: GO:0050387 xref: MetaCyc:URETHANASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007739 name: uronate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-galacturonate + NAD+ + H2O = D-galactarate + NADH." [EC:1.1.1.203, MetaCyc:URONATE-DEHYDROGENASE-RXN] synonym: "uronate: NAD-oxidoreductase activity" EXACT [EC:1.1.1.203] synonym: "uronate:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.203] synonym: "uronic acid dehydrogenase activity" EXACT [EC:1.1.1.203] xref: EC:1.1.1.203 xref: GO:0050388 xref: MetaCyc:URONATE-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007740 name: uronolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate." [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN] synonym: "D-glucurono-6,2-lactone lactonohydrolase activity" EXACT [EC:3.1.1.19] synonym: "glucuronolactonase activity" EXACT [EC:3.1.1.19] xref: EC:3.1.1.19 xref: GO:0050389 xref: MetaCyc:URONOLACTONASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007741 name: valine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine = 2-methylpropanamine + CO2." [EC:4.1.1.14, MetaCyc:VALINE-DECARBOXYLASE-RXN] synonym: "L-valine carboxy-lyase (2-methylpropanamine-forming)" EXACT [EC:4.1.1.14] synonym: "L-valine carboxy-lyase activity" EXACT [EC:4.1.1.14] synonym: "l-valine carboxy-lyase activity" EXACT [EC:4.1.1.14] synonym: "leucine decarboxylase activity" EXACT [EC:4.1.1.14] xref: EC:4.1.1.14 xref: GO:0050390 xref: MetaCyc:VALINE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007742 name: valine dehydrogenase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH." [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-(NADP+)-RXN] synonym: "L-valine:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.8] synonym: "valine dehydrogenase (NADP+) activity" EXACT [] synonym: "valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)" EXACT [EC:1.4.1.8] xref: EC:1.4.1.8 xref: GO:0050391 xref: MetaCyc:VALINE-DEHYDROGENASE-(NADP+)-RXN is_a: CCO:F0003239 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007743 name: vicianin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose." [EC:3.2.1.119, MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN] synonym: "(R)-vicianin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.119] synonym: "vicianin b-glucosidase activity" EXACT [] synonym: "vicianin hydrolase activity" EXACT [EC:3.2.1.119] xref: EC:3.2.1.119 xref: GO:0050392 xref: MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007744 name: vinylacetyl-CoA delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: vinylacetyl-CoA = crotonyl-CoA." [EC:5.3.3.3, MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN] subset: gosubset_prok synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.3] synonym: "vinylacetyl coenzyme A delta-isomerase activity" EXACT [EC:5.3.3.3] synonym: "vinylacetyl coenzyme A isomerase activity" EXACT [EC:5.3.3.3] synonym: "vinylacetyl-CoA D-isomerase activity" EXACT [] synonym: "vinylacetyl-CoA delta3-delta2-isomerase activity" EXACT [EC:5.3.3.3] xref: EC:5.3.3.3 xref: GO:0050393 xref: MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0007745 name: viomycin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin." [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN] subset: gosubset_prok synonym: "ATP:viomycin O-phosphotransferase activity" EXACT [EC:2.7.1.103] synonym: "capreomycin phosphotransferase activity" EXACT [EC:2.7.1.103] synonym: "viomycin phosphotransferase activity" EXACT [EC:2.7.1.103] xref: EC:2.7.1.103 xref: GO:0050394 xref: MetaCyc:VIOMYCIN-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007746 name: vitexin beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: vitexin + UDP-D-glucose = vitexin 2'-O-beta-D-glucoside + UDP." [EC:2.4.1.105, MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105] synonym: "UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105] synonym: "uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.105] synonym: "vitexin b-glucosyltransferase activity" EXACT [] xref: EC:2.4.1.105 xref: GO:0050395 xref: MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007747 name: vomifoliol 4'-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (+-)-6-hydroxy-3-oxo-alpha-ionol = NADH + (+-)-6-hydroxy-3-oxo-alpha-ionone." [EC:1.1.1.221, MetaCyc:VOMIFOLIOL-4] synonym: "vomifoliol:NAD+ 4'-oxidoreductase activity" EXACT [EC:1.1.1.221] xref: EC:1.1.1.221 xref: GO:0050396 xref: MetaCyc:VOMIFOLIOL-4 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007748 name: Watasenia-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light." [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN] synonym: "luciferase activity" BROAD [EC:1.13.12.8] synonym: "Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.8] synonym: "Watasenia-type luciferase activity" EXACT [EC:1.13.12.8] synonym: "watasenia-type luciferase activity" EXACT [EC:1.13.12.8] xref: EC:1.13.12.8 xref: GO:0050397 xref: MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: CCO:F0006100 ! luciferin monooxygenase activity [Term] id: CCO:F0007749 name: wax-ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate." [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN] synonym: "jojoba wax esterase" NARROW [EC:3.1.1.50] synonym: "wax-ester acylhydrolase activity" EXACT [EC:3.1.1.50] synonym: "WEH" RELATED [EC:3.1.1.50] xref: EC:3.1.1.50 xref: GO:0050398 xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007750 name: xanthommatin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD+ = xanthommatin + NADH." [EC:1.3.1.41, MetaCyc:XANTHOMMATIN-REDUCTASE-RXN] synonym: "5,12-dihydroxanthommatin:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.41] xref: EC:1.3.1.41 xref: GO:0050399 xref: MetaCyc:XANTHOMMATIN-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007751 name: xylitol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xylitol = ADP + xylitol 5-phosphate." [EC:2.7.1.122, MetaCyc:XYLITOL-KINASE-RXN] synonym: "ATP:xylitol 5-phosphotransferase activity" EXACT [EC:2.7.1.122] synonym: "xylitol phosphotransferase activity" EXACT [EC:2.7.1.122] xref: EC:2.7.1.122 xref: GO:0050400 xref: MetaCyc:XYLITOL-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007752 name: xylonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-xylonate + H2O." [EC:4.2.1.82, MetaCyc:XYLONATE-DEHYDRATASE-RXN] synonym: "D-xylo-aldonate dehydratase activity" EXACT [EC:4.2.1.82] synonym: "D-xylonate dehydratase activity" EXACT [EC:4.2.1.82] synonym: "D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)" EXACT [EC:4.2.1.82] synonym: "D-xylonate hydro-lyase activity" EXACT [EC:4.2.1.82] xref: EC:4.2.1.82 xref: GO:0050401 xref: MetaCyc:XYLONATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007753 name: xylono-1,4-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate." [EC:3.1.1.68, MetaCyc:XYLONO-1] synonym: "D-xylono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.68] synonym: "xylono-g-lactonase activity" EXACT [EC:3.1.1.68] synonym: "xylonolactonase activity" EXACT [EC:3.1.1.68] xref: EC:3.1.1.68 xref: GO:0050402 xref: MetaCyc:XYLONO-1 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007754 name: trans-zeatin O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + trans-zeatin = UDP + O-beta-D-glucosyl-trans-zeatin." [EC:2.4.1.203, MetaCyc:ZEATIN-O-BETA-D-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "uridine diphosphoglucose-zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "zeatin O-b-D-glucosyltransferase activity" EXACT [] synonym: "zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203] xref: EC:2.4.1.203 xref: GO:0050403 xref: MetaCyc:RXN-4723 is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007755 name: zeatin O-beta-D-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-xylose + zeatin = UDP + O-beta-D-xylosylzeatin." [EC:2.4.1.204, MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN] comment: Note that this function was formerly EC:2.4.1.204. synonym: "UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.40] synonym: "uridine diphosphoxylose-zeatin xylosyltransferase activity" EXACT [EC:2.4.2.40] synonym: "zeatin O-b-D-xylosyltransferase activity" EXACT [] synonym: "zeatin O-xylosyltransferase activity" EXACT [EC:2.4.2.40] xref: EC:2.4.2.40 xref: GO:0050404 xref: MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN is_a: CCO:F0005581 ! UDP-xylosyltransferase activity [Term] id: CCO:F0007760 name: indolylacetylinositol arabinosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside." [EC:2.4.2.34, MetaCyc:2.4.2.34-RXN] subset: gosubset_prok synonym: "arabinosylindolylacetylinositol synthase activity" EXACT [EC:2.4.2.34] synonym: "UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34] synonym: "UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34] xref: EC:2.4.2.34 xref: GO:0050409 xref: MetaCyc:2.4.2.34-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003338 ! transferase activity, transferring pentosyl groups [Term] id: CCO:F0007761 name: 3-oxolaurate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxododecanoate = 2-undecanone + CO2." [EC:4.1.1.56, MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN] synonym: "3-oxododecanoate carboxy-lyase (2-undecanone-forming)" EXACT [EC:4.1.1.56] synonym: "3-oxododecanoate carboxy-lyase activity" EXACT [EC:4.1.1.56] synonym: "beta-ketoacyl decarboxylase activity" EXACT [EC:4.1.1.56] synonym: "beta-ketolaurate decarboxylase activity" EXACT [EC:4.1.1.56] xref: EC:4.1.1.56 xref: GO:0050410 xref: MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007762 name: agaritine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor." [EC:2.3.2.9, MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN] synonym: "(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9] synonym: "(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9] synonym: "agaritine g-glutamyltransferase activity" EXACT [] xref: EC:2.3.2.9 xref: GO:0050411 xref: MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN is_a: CCO:F0003330 ! transferase activity, transferring amino-acyl groups [Term] id: CCO:F0007763 name: cinnamate beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + trans-cinnamate = UDP + trans-cinnamoyl beta-D-glucoside." [EC:2.4.1.177, MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN] synonym: "cinnamate b-D-glucosyltransferase activity" EXACT [] synonym: "cinnamate glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177] synonym: "UDPG:t-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177] synonym: "UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177] synonym: "uridine diphosphoglucose-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177] xref: EC:2.4.1.177 xref: GO:0050412 xref: MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007764 name: D-alanine 2-hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = tetrahydrofolate + 2-methylserine." [EC:2.1.2.7, MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN] synonym: "2-methylserine hydroxymethyltransferase activity" EXACT [EC:2.1.2.7] synonym: "5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity" EXACT [EC:2.1.2.7] synonym: "D-alanine hydroxymethyltransferase activity" EXACT [] xref: EC:2.1.2.7 xref: GO:0050413 xref: MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN is_a: CCO:F0003318 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: CCO:F0007765 name: formimidoylaspartate deiminase activity namespace: molecular_function def: "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3." [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN] synonym: "formiminoaspartate deiminase activity" EXACT [] synonym: "N-formimidoyl-L-aspartate iminohydrolase activity" EXACT [EC:3.5.3.5] xref: EC:3.5.3.5 xref: GO:0050414 xref: MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0007766 name: formimidoylglutamase activity namespace: molecular_function def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide." [EC:3.5.3.8, MetaCyc:FORMIMINOGLUTAMASE-RXN] subset: gosubset_prok synonym: "formiminoglutamase activity" EXACT [] synonym: "formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8] synonym: "N-formimidoyl-L-glutamate formimidoylhydrolase activity" EXACT [EC:3.5.3.8] synonym: "N-formimino-L-glutamate formiminohydrolase activity" EXACT [EC:3.5.3.8] synonym: "N-formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8] xref: EC:3.5.3.8 xref: GO:0050415 xref: MetaCyc:FORMIMINOGLUTAMASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0007767 name: formimidoylglutamate deiminase activity namespace: molecular_function def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3." [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN] subset: gosubset_prok synonym: "formiminoglutamate deiminase activity" EXACT [] synonym: "formiminoglutamic iminohydrolase activity" EXACT [EC:3.5.3.13] synonym: "N-formimidoyl-L-glutamate iminohydrolase activity" EXACT [EC:3.5.3.13] xref: EC:3.5.3.13 xref: GO:0050416 xref: MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN is_a: CCO:F0003382 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: CCO:F0007768 name: glutamin-(asparagin-)ase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-glutamine (or L-asparagine) = NH3 + L-glutamate (or L-aspartate)." [EC:3.5.1.38, MetaCyc:GLUTAMINASE-(ASPARAGIN-)ASE-RXN] subset: gosubset_prok synonym: "glutaminase-(asparagin-)ase activity" EXACT [] synonym: "glutaminase-asparaginase activity" EXACT [EC:3.5.1.38] synonym: "L-ASNase/L-GLNase activity" EXACT [EC:3.5.1.38] synonym: "L-asparagine/L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.38] synonym: "L-glutamine(L-asparagine) amidohydrolase activity" EXACT [EC:3.5.1.38] xref: EC:3.5.1.38 xref: GO:0050417 xref: MetaCyc:GLUTAMINASE-(ASPARAGIN-)ASE-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007769 name: hydroxylamine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor." [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN] subset: gosubset_prok synonym: "ammonia:(acceptor) oxidoreductase activity" EXACT [EC:1.7.99.1] synonym: "ammonia:acceptor oxidoreductase activity" EXACT [EC:1.7.99.1] synonym: "hydroxylamine (acceptor) reductase activity" EXACT [EC:1.7.99.1] xref: EC:1.7.99.1 xref: GO:0050418 xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN is_a: CCO:F0003256 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: CCO:F0007770 name: hydroxymandelonitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate." [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN] synonym: "(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.11] synonym: "(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity" EXACT [EC:4.1.2.11] synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.11] synonym: "sorghum hydroxynitrile lyase activity" EXACT [EC:4.1.2.11] xref: EC:4.1.2.11 xref: GO:0050419 xref: MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007771 name: maltose synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate." [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN] synonym: "alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)" EXACT [EC:2.4.1.139] xref: EC:2.4.1.139 xref: GO:0050420 xref: MetaCyc:MALTOSE-SYNTHASE-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0007772 name: nitrite reductase (NO-forming) activity namespace: molecular_function def: "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = NO2(-) (nitrite) + ferrocytochrome c + 2 H+." [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-(CYTOCHROME)-RXN] comment: Note that EC:1.7.99.3 was merged into this term. subset: gosubset_prok synonym: "[nitrite reductase (cytochrome)]" RELATED [EC:1.7.2.1] synonym: "cd-cytochrome nitrite reductase activity" NARROW [EC:1.7.2.1] synonym: "cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity" NARROW [EC:1.7.2.1] synonym: "cytochrome c-551:O2, NO2+ oxidoreductase activity" EXACT [EC:1.7.2.1] synonym: "cytochrome cd activity" NARROW [EC:1.7.2.1] synonym: "cytochrome cd1 activity" NARROW [EC:1.7.2.1] synonym: "methyl viologen-nitrite reductase activity" NARROW [EC:1.7.2.1] synonym: "nitric-oxide:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.1] synonym: "nitrite reductase (cytochrome) activity" EXACT [] synonym: "nitrite reductase (cytochrome; NO-forming) activity" EXACT [EC:1.7.2.1] synonym: "nitrite reductase activity" EXACT [] synonym: "Pseudomonas cytochrome oxidase activity" NARROW [EC:1.7.2.1] xref: EC:1.7.2.1 xref: GO:0016666 xref: GO:0050421 xref: MetaCyc:NITRITE-REDUCTASE-(CYTOCHROME)-RXN is_a: CCO:F0003257 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: CCO:F0007773 name: strictosidine beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + strictosidine = D-glucose + strictosidine aglycone." [EC:3.2.1.105, MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN] synonym: "strictosidine b-glucosidase activity" EXACT [] synonym: "strictosidine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.105] xref: EC:3.2.1.105 xref: GO:0050422 xref: MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007774 name: thiamin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: thiamin + 2 O2 = thiamin acetic acid + 2 H2O2." [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN] synonym: "thiamin dehydrogenase activity" EXACT [EC:1.1.3.23] synonym: "thiamin:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23] synonym: "thiamine dehydrogenase activity" EXACT [EC:1.1.3.23] synonym: "thiamine oxidase activity" EXACT [] synonym: "thiamine:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23] xref: EC:1.1.3.23 xref: GO:0050423 xref: MetaCyc:THIAMIN-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007775 name: alanine carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN] subset: gosubset_prok synonym: "N-benzoyl-L-alanine-amidohydrolase activity" EXACT [EC:3.4.17.6] xref: EC:3.4.17.6 xref: GO:0050424 xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0007776 name: carboxypeptidase B activity namespace: molecular_function def: "Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN] subset: gosubset_prok synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2] synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" EXACT [EC:3.4.17.2] synonym: "protaminase activity" RELATED [EC:3.4.17.2] synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2] xref: EC:3.4.17.2 xref: GO:0050425 xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN is_a: CCO:F0000650 ! metallocarboxypeptidase activity [Term] id: CCO:F0007777 name: peptidyl-glycinamidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [EC:3.4.19.2, MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN] synonym: "carboxamidopeptidase activity" EXACT [EC:3.4.19.2] synonym: "carboxyamidase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl amino acid amide hydrolase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl carboxy-amidase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl carboxyamidase activity" EXACT [EC:3.4.19.2] xref: EC:3.4.19.2 xref: GO:0050426 xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN is_a: CCO:F0001792 ! omega peptidase activity [Term] id: CCO:F0007778 name: calcium-dependent phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate; requires Ca2+." [EC:3.1.4.3] xref: GO:0050429 is_a: CCO:F0001003 ! phospholipase C activity [Term] id: CCO:F0007779 name: syntaxin-6 binding namespace: molecular_function def: "Interacting selectively with the SNAP receptor syntaxin-6." [GOC:ai] xref: GO:0050430 is_a: CCO:F0004214 ! syntaxin binding [Term] id: CCO:F0007780 name: transforming growth factor beta binding namespace: molecular_function def: "Interacting selectively with TGFbeta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "TGF-beta binding" EXACT [] synonym: "TGFbeta binding" EXACT [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] xref: GO:0050431 is_a: CCO:F0004188 ! growth factor binding is_a: CCO:F0004221 ! cytokine binding [Term] id: CCO:F0007781 name: microfibril binding namespace: molecular_function def: "Interacting selectively with a microfibril, any small fibril occurring in biological material." [GOC:ai] comment: See also the cellular component term 'microfibril ; GO:0001527'. xref: GO:0050436 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0007783 name: 2-ethylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA ." [EC:2.3.3.6, MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN] synonym: "(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.6] synonym: "2-ethylmalate-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.6] synonym: "acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.6] synonym: "propylmalate synthase activity" EXACT [EC:2.3.3.6] synonym: "propylmalic synthase activity" EXACT [EC:2.3.3.6] xref: EC:2.3.3.6 xref: GO:0050438 xref: MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0007784 name: 2-hydroxy-3-oxoadipate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 ." [EC:2.2.1.5, MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN] synonym: "2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity" EXACT [EC:2.2.1.5] synonym: "2-hydroxy-3-oxoadipate synthetase activity" EXACT [EC:2.2.1.5] synonym: "2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.5] synonym: "alpha-ketoglutaric-glyoxylic carboligase activity" EXACT [EC:2.2.1.5] synonym: "oxoglutarate: glyoxylate carboligase activity" EXACT [EC:2.2.1.5] synonym: "oxoglutarate:glyoxylate carboligase activity" EXACT [EC:2.2.1.5] xref: EC:2.2.1.5 xref: GO:0050439 xref: MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN is_a: CCO:F0003320 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: CCO:F0007785 name: 2-methylcitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: propanoyl-CoA + H2O + oxaloacetate = (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA." [EC:2.3.3.5, MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN] subset: gosubset_prok synonym: "2-methylcitrate oxaloacetate-lyase activity" EXACT [EC:2.3.3.5] synonym: "MCS activity" EXACT [EC:2.3.3.5] synonym: "methylcitrate synthase activity" EXACT [EC:2.3.3.5] synonym: "methylcitrate synthetase activity" EXACT [EC:2.3.3.5] synonym: "propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)" EXACT [EC:2.3.3.5] xref: EC:2.3.3.5 xref: GO:0050440 xref: MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0007786 name: 3-ethylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + H2O + glyoxylate = 3-ethylmalate + CoA ." [EC:2.3.3.7, MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN] synonym: "2-ethyl-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.7] synonym: "3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity" EXACT [EC:2.3.3.7] synonym: "butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)" EXACT [EC:2.3.3.7] xref: EC:2.3.3.7 xref: GO:0050441 xref: MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0007787 name: 3-propylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: pentanoyl-CoA + H2O + glyoxylate = 3-propylmalate + CoA ." [EC:2.3.3.12, MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN] synonym: "3-(n-propyl)-malate synthase activity" EXACT [EC:2.3.3.12] synonym: "3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity" EXACT [EC:2.3.3.12] synonym: "beta-n-propylmalate synthase activity" EXACT [EC:2.3.3.12] synonym: "n-propylmalate synthase activity" EXACT [EC:2.3.3.12] synonym: "N-propylmalate synthase activity" EXACT [EC:2.3.3.12] synonym: "pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)" EXACT [EC:2.3.3.12] xref: EC:2.3.3.12 xref: GO:0050442 xref: MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0007788 name: aquacobalamin reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+." [EC:1.16.1.5, MetaCyc:AQUACOBALAMIN-REDUCTASE-(NADPH)-RXN] synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) activity" EXACT [EC:1.16.1.5] synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.16.1.5] synonym: "cob(II)alamin:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.5] synonym: "NADPH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.5] synonym: "NADPH2:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5] synonym: "NADPH:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5] xref: EC:1.16.1.5 xref: GO:0050444 xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-(NADPH)-RXN is_a: CCO:F0003305 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: CCO:F0007789 name: asparagusate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + NADH + H+." [EC:1.8.1.11, MetaCyc:ASPARAGUSATE-REDUCTASE-(NADH)-RXN] synonym: "3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.11] synonym: "asparagusate dehydrogenase activity" EXACT [EC:1.8.1.11] synonym: "asparagusate reductase (NADH) activity" EXACT [] synonym: "asparagusate reductase (NADH2)" EXACT [EC:1.8.1.11] synonym: "asparagusic dehydrogenase activity" EXACT [EC:1.8.1.11] synonym: "NADH2:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11] synonym: "NADH:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11] xref: EC:1.8.1.11 xref: GO:0050445 xref: MetaCyc:ASPARAGUSATE-REDUCTASE-(NADH)-RXN is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007790 name: azobenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+." [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN] synonym: "azo reductase activity" BROAD [EC:1.7.1.6] synonym: "azo-dye reductase activity" BROAD [EC:1.7.1.6] synonym: "azoreductase activity" BROAD [EC:1.7.1.6] synonym: "dibromopropylaminophenylazobenzoic azoreductase activity" EXACT [EC:1.7.1.6] synonym: "dimethylaminobenzene reductase activity" EXACT [EC:1.7.1.6] synonym: "methyl red azoreductase activity" NARROW [EC:1.7.1.6] synonym: "N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "N,N-dimethyl-4-phenylazoaniline azoreductase activity" EXACT [EC:1.7.1.6] synonym: "NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "NADPH-dependent azoreductase activity" BROAD [EC:1.7.1.6] synonym: "NADPH2-dependent azoreductase activity" EXACT [EC:1.7.1.6] synonym: "NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "NADPH:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "NC-reductase activity" NARROW [EC:1.7.1.6] synonym: "new coccine (NC)-reductase" RELATED [EC:1.7.1.6] synonym: "New coccine (NC)-reductase activity" NARROW [EC:1.7.1.6] synonym: "nicotinamide adenine dinucleotide (phosphate) azoreductase activity" EXACT [EC:1.7.1.6] synonym: "orange I azoreductase activity" NARROW [EC:1.7.1.6] synonym: "orange II azoreductase activity" NARROW [EC:1.7.1.6] synonym: "p-aminoazobenzene reductase activity" EXACT [EC:1.7.1.6] synonym: "p-dimethylaminoazobenzene azoreductase activity" EXACT [EC:1.7.1.6] xref: EC:1.7.1.6 xref: GO:0050446 xref: MetaCyc:AZOBENZENE-REDUCTASE-RXN is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0007791 name: zeatin 9-aminocarboxyethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-serine + zeatin = lupinate + acetate." [EC:2.5.1.50, MetaCyc:BETA-(9-CYTOKININ)-ALANINE-SYNTHASE-RXN] synonym: "3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50] synonym: "beta-(9-cytokinin)-alanine synthase activity" EXACT [] synonym: "beta-(9-cytokinin)alanine synthase activity" EXACT [EC:2.5.1.50] synonym: "lupinate synthetase activity" EXACT [EC:2.5.1.50] synonym: "lupinic acid synthase activity" EXACT [EC:2.5.1.50] synonym: "lupinic acid synthetase activity" EXACT [EC:2.5.1.50] synonym: "O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity" EXACT [EC:2.5.1.50] synonym: "O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)" EXACT [EC:2.5.1.50] synonym: "O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50] xref: EC:2.5.1.50 xref: GO:0050447 xref: MetaCyc:BETA-(9-CYTOKININ)-ALANINE-SYNTHASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007792 name: beta-cyclopiazonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-cyclopiazonate + acceptor = alpha-cyclopiazonate + reduced acceptor." [EC:1.21.99.1, MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN] synonym: "b-cyclopiazonate dehydrogenase activity" EXACT [] synonym: "beta-cyclopiazonate oxidocyclase activity" EXACT [EC:1.21.99.1] synonym: "beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1] synonym: "beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1] synonym: "beta-cyclopiazonic oxidocyclase activity" EXACT [EC:1.21.99.1] xref: EC:1.21.99.1 xref: GO:0050448 xref: MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN is_a: CCO:F0006306 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond [Term] id: CCO:F0007793 name: casbene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = casbene + diphosphate." [EC:4.2.3.8, MetaCyc:CASBENE-SYNTHASE-RXN] synonym: "casbene synthetase activity" EXACT [EC:4.2.3.8] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.8] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)" EXACT [EC:4.2.3.8] xref: EC:4.2.3.8 xref: GO:0050449 xref: MetaCyc:CASBENE-SYNTHASE-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0007794 name: citrate (Re)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA ." [EC:2.3.3.3, MetaCyc:CITRATE-(RE)-SYNTHASE-RXN] synonym: "(R)-citrate synthase activity" EXACT [EC:2.3.3.3] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]" RELATED [EC:2.3.3.3] synonym: "citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.3] synonym: "citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]" RELATED [EC:2.3.3.3] synonym: "Re-citrate-synthase activity" EXACT [EC:2.3.3.3] xref: EC:2.3.3.3 xref: GO:0050450 xref: MetaCyc:CITRATE-(RE)-SYNTHASE-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0007795 name: CoA-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+." [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-(NADH)-RXN] synonym: "CoA-disulfide reductase (NAD(P)H) activity" RELATED [EC:1.8.1.14] synonym: "CoA-disulfide reductase (NADH) activity" EXACT [] synonym: "CoA-disulfide reductase (NADH2)" EXACT [EC:1.8.1.14] synonym: "CoA-disulfide reductase [NAD(P)H]" RELATED [EC:1.8.1.14] synonym: "CoA-disulphide reductase activity" EXACT [] synonym: "CoA:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "CoA:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "CoADR activity" EXACT [EC:1.8.1.14] synonym: "coenzyme A disulfide reductase activity" EXACT [EC:1.8.1.14] synonym: "NADH2:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "NADH:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] xref: EC:1.8.1.14 xref: GO:0050451 xref: MetaCyc:COA-DISULFIDE-REDUCTASE-(NADH)-RXN is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007796 name: CoA-glutathione reductase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+." [EC:1.8.1.10, MetaCyc:COA-GLUTATHIONE-REDUCTASE-(NADPH)-RXN] synonym: "CoA-glutathione reductase (NADPH) activity" EXACT [] synonym: "coenzyme A disulfide-glutathione reductase activity" EXACT [EC:1.8.1.10] synonym: "coenzyme A glutathione disulfide reductase activity" EXACT [EC:1.8.1.10] synonym: "glutathione:NADP+ oxidoreductase (CoA-acylating)" EXACT [EC:1.8.1.10] synonym: "NADPH-dependent coenzyme A-SS-glutathione reductase activity" EXACT [EC:1.8.1.10] synonym: "NADPH2:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10] synonym: "NADPH:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10] xref: EC:1.8.1.10 xref: GO:0050452 xref: MetaCyc:COA-GLUTATHIONE-REDUCTASE-(NADPH)-RXN is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007797 name: cob(II)alamin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(I)alamin + NAD+ = 2 cob(II)alamin + NADH + H+." [EC:1.16.1.4, MetaCyc:COB(II)ALAMIN-REDUCTASE-RXN] synonym: "B(12r) reductase activity" EXACT [EC:1.16.1.4] synonym: "B12r reductase activity" EXACT [EC:1.16.1.4] synonym: "cob(I)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.4] synonym: "NADH2:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4] synonym: "NADH:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4] synonym: "vitamin B(12r) reductase activity" EXACT [EC:1.16.1.4] synonym: "vitamin B12 reductase activity" EXACT [] synonym: "vitamin B12 reduction" RELATED [] synonym: "vitamin B12r reductase activity" EXACT [EC:1.16.1.4] xref: EC:1.16.1.4 xref: GO:0050453 xref: MetaCyc:COB(II)ALAMIN-REDUCTASE-RXN is_a: CCO:F0003305 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: CCO:F0007798 name: coenzyme F420 hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2 + coenzyme F420 = reduced coenzyme F420." [EC:1.12.98.1, MetaCyc:COENZYME-F420-HYDROGENASE-RXN] subset: gosubset_prok synonym: "8-hydroxy-5-deazaflavin-reducing hydrogenase activity" EXACT [EC:1.12.98.1] synonym: "coenzyme F420-dependent hydrogenase activity" EXACT [EC:1.12.98.1] synonym: "F420-reducing hydrogenase activity" EXACT [EC:1.12.98.1] synonym: "hydrogen:coenzyme F420 oxidoreductase activity" EXACT [EC:1.12.98.1] xref: EC:1.12.98.1 xref: GO:0050454 xref: MetaCyc:COENZYME-F420-HYDROGENASE-RXN is_a: CCO:F0006309 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors [Term] id: CCO:F0007799 name: columbamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O." [EC:1.21.3.2, MetaCyc:COLUMBAMINE-OXIDASE-RXN] synonym: "berberine synthase activity" EXACT [EC:1.21.3.2] synonym: "columbamine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.2] xref: EC:1.21.3.2 xref: GO:0050455 xref: MetaCyc:COLUMBAMINE-OXIDASE-RXN is_a: CCO:F0006307 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: CCO:F0007800 name: cystine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + NADH + H+." [EC:1.8.1.6, MetaCyc:CYSTINE-REDUCTASE-(NADH)-RXN] subset: gosubset_prok synonym: "cystine reductase (NADH) activity" EXACT [EC:1.8.1.6] synonym: "cystine reductase (NADH2)" EXACT [EC:1.8.1.6] synonym: "L-cysteine:NAD+ oxidoreductase" EXACT [EC:1.8.1.6] synonym: "NADH-dependent cystine reductase activity" EXACT [EC:1.8.1.6] synonym: "NADH2:L-cystine oxidoreductase" EXACT [EC:1.8.1.6] synonym: "NADH:L-cystine oxidoreductase activity" EXACT [EC:1.8.1.6] xref: EC:1.8.1.6 xref: GO:0050456 xref: MetaCyc:CYSTINE-REDUCTASE-(NADH)-RXN is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007801 name: decylcitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: lauroyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA ." [EC:2.3.3.2, MetaCyc:DECYLCITRATE-SYNTHASE-RXN] synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.2] synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)" EXACT [EC:2.3.3.2] synonym: "2-decylcitrate synthase activity" EXACT [EC:2.3.3.2] synonym: "dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.2] xref: EC:2.3.3.2 xref: GO:0050457 xref: MetaCyc:DECYLCITRATE-SYNTHASE-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0007802 name: decylhomocitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: dodecanoyl-CoA + H2O + 2-oxoglutarate = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA ." [EC:2.3.3.4, MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN] synonym: "2-decylhomocitrate synthase activity" EXACT [EC:2.3.3.4] synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.4] synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)" EXACT [EC:2.3.3.4] synonym: "dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.4] xref: EC:2.3.3.4 xref: GO:0050458 xref: MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0007803 name: ethanolamine-phosphate phospho-lyase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate." [EC:4.2.3.2, MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN] synonym: "amino alcohol O-phosphate phospholyase activity" BROAD [EC:4.2.3.2] synonym: "ethanolamine-phosphate phospho-lyase (deaminating)" EXACT [EC:4.2.3.2] synonym: "ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)" EXACT [EC:4.2.3.2] synonym: "O-phosphoethanolamine-phospholyase activity" EXACT [EC:4.2.3.2] synonym: "O-phosphorylethanol-amine phospho-lyase activity" EXACT [EC:4.2.3.2] xref: EC:4.2.3.2 xref: GO:0050459 xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0007804 name: hydroxylamine reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+." [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-(NADH)-RXN] synonym: "ammonium dehydrogenase activity" EXACT [EC:1.7.1.10] synonym: "ammonium:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.10] synonym: "hydroxylamine reductase (NADH2)" EXACT [EC:1.7.1.10] synonym: "N-hydroxy amine reductase activity" EXACT [EC:1.7.1.10] synonym: "NADH-hydroxylamine reductase activity" EXACT [EC:1.7.1.10] synonym: "NADH2:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10] synonym: "NADH:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10] xref: EC:1.7.1.10 xref: GO:0050460 xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-(NADH)-RXN is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0007805 name: L-mimosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate." [EC:2.5.1.52, MetaCyc:L-MIMOSINE-SYNTHASE-RXN] synonym: "3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity" EXACT [EC:2.5.1.52] synonym: "O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)" EXACT [EC:2.5.1.52] synonym: "O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52] xref: EC:2.5.1.52 xref: GO:0050461 xref: MetaCyc:L-MIMOSINE-SYNTHASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007806 name: N-acetylneuraminate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate ." [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN] synonym: "(NANA)condensing enzyme activity" EXACT [EC:2.5.1.56] synonym: "N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.56] synonym: "N-acetylneuraminic acid synthase activity" EXACT [EC:2.5.1.56] synonym: "NeuAc synthase activity" EXACT [EC:2.5.1.56] synonym: "phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.56] xref: EC:2.5.1.56 xref: GO:0050462 xref: MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007807 name: nitrate reductase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: NO2- (nitrite) + NAD(P)+ + H2O = NO3- (nitrate) + NAD(P)H + H+." [EC:1.7.1.2, MetaCyc:NITRATE-REDUCTASE-(NAD(P)H)-RXN] synonym: "assimilatory NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2] synonym: "assimilatory nitrate reductase activity" RELATED [EC:1.7.1.2] synonym: "NAD(P)H bispecific nitrate reductase activity" EXACT [EC:1.7.1.2] synonym: "NAD(P)H-nitrate reductase activity" EXACT [EC:1.7.1.2] synonym: "NAD(P)H2:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2] synonym: "NAD(P)H:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2] synonym: "nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.2] synonym: "nitrate reductase [NAD(P)H2]" RELATED [EC:1.7.1.2] synonym: "nitrate reductase NAD(P)H activity" EXACT [EC:1.7.1.2] synonym: "nitrite:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.2] xref: EC:1.7.1.2 xref: GO:0050463 xref: MetaCyc:NITRATE-REDUCTASE-(NAD(P)H)-RXN is_a: CCO:F0002276 ! nitrate reductase activity is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0007808 name: nitrate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+." [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-(NADPH)-RXN] synonym: "assimilatory NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.3] synonym: "assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "NADPH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.3] synonym: "NADPH:nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "nitrate reductase (NADPH(2)) activity" EXACT [EC:1.7.1.3] synonym: "nitrate reductase (NADPH2)" EXACT [EC:1.7.1.3] synonym: "nitrite:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.3] synonym: "triphosphopyridine nucleotide-nitrate reductase activity" EXACT [EC:1.7.1.3] xref: EC:1.7.1.3 xref: GO:0050464 xref: MetaCyc:NITRATE-REDUCTASE-(NADPH)-RXN is_a: CCO:F0002276 ! nitrate reductase activity is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0007809 name: nitroquinoline-N-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+." [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN] synonym: "4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.9] synonym: "4-nitroquinoline 1-oxide reductase activity" EXACT [EC:1.7.1.9] synonym: "4NQO reductase activity" EXACT [EC:1.7.1.9] synonym: "NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9] synonym: "NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9] xref: EC:1.7.1.9 xref: GO:0050465 xref: MetaCyc:1.7.1.9-RXN is_a: CCO:F0006253 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: CCO:F0007810 name: pentalenene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = pentalenene + diphosphate." [EC:4.2.3.7, MetaCyc:PENTALENENE-SYNTHASE-RXN] subset: gosubset_prok synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7] synonym: "2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7] synonym: "pentalenene synthetase activity" EXACT [EC:4.2.3.7] xref: EC:4.2.3.7 xref: GO:0050467 xref: MetaCyc:PENTALENENE-SYNTHASE-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0007811 name: reticuline oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-reticuline + O2 = (S)-scoulerine + H2O2." [EC:1.21.3.3, MetaCyc:RETICULINE-OXIDASE-RXN] synonym: "(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)" EXACT [EC:1.21.3.3] synonym: "BBE" RELATED [EC:1.21.3.3] synonym: "berberine bridge enzyme activity" EXACT [EC:1.21.3.3] synonym: "berberine-bridge-forming enzyme activity" EXACT [EC:1.21.3.3] synonym: "tetrahydroprotoberberine synthase activity" EXACT [EC:1.21.3.3] xref: EC:1.21.3.3 xref: GO:0050468 xref: MetaCyc:RETICULINE-OXIDASE-RXN is_a: CCO:F0006307 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: CCO:F0007812 name: sabinene-hydrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + geranyl-PP = pyrophosphate + sabinene hydrate." [EC:4.2.3.11, MetaCyc:4.2.3.11-RXN] synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)" EXACT [EC:4.2.3.11] synonym: "sabinene hydrate cyclase activity" EXACT [EC:4.2.3.11] xref: EC:4.2.3.11 xref: GO:0050469 xref: MetaCyc:4.2.3.11-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0007813 name: trimethylamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein." [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN] subset: gosubset_prok synonym: "TMADh activity" EXACT [EC:1.5.8.2] synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" EXACT [EC:1.5.8.2] xref: EC:1.5.8.2 xref: GO:0050470 xref: MetaCyc:1.5.8.2-RXN is_a: CCO:F0006311 ! oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor [Term] id: CCO:F0007814 name: uracilylalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate." [EC:2.5.1.53, MetaCyc:URACILYLALANINE-SYNTHASE-RXN] synonym: "3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53] synonym: "isowillardiine synthase activity" EXACT [EC:2.5.1.53] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity" EXACT [EC:2.5.1.53] synonym: "O3-acetyl-L-serine acetate-lyase (adding uracil)" EXACT [EC:2.5.1.53] synonym: "O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53] synonym: "willardiine synthase activity" EXACT [EC:2.5.1.53] synonym: "Willardiine synthase activity" EXACT [EC:2.5.1.53] xref: EC:2.5.1.53 xref: GO:0050471 xref: MetaCyc:URACILYLALANINE-SYNTHASE-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007815 name: zeatin reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrozeatin + NADP+ = zeatin + NADPH." [EC:1.3.1.69, MetaCyc:ZEATIN-REDUCTASE-RXN] synonym: "dihydrozeatin:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.69] xref: EC:1.3.1.69 xref: GO:0050472 xref: MetaCyc:ZEATIN-REDUCTASE-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007816 name: arachidonate 15-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate." [EC:1.13.11.33] subset: gosubset_prok synonym: "15-lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "arachidonate omega(6) lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "arachidonate omega6 lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "arachidonate:oxygen 15-oxidoreductase activity" EXACT [EC:1.13.11.33] synonym: "linoleic acid omega6-lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "omega6 lipoxygenase activity" EXACT [EC:1.13.11.33] xref: EC:1.13.11.33 xref: GO:0050473 xref: MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007818 name: acetylenedicarboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate." [EC:4.1.1.78] synonym: "acetylenedicarboxylate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.78] synonym: "acetylenedicarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.78] synonym: "acetylenedicarboxylate hydrase activity" EXACT [EC:4.1.1.78] synonym: "acetylenedicarboxylate hydratase activity" EXACT [EC:4.1.1.78] xref: EC:4.1.1.78 xref: GO:0050476 xref: MetaCyc:4.1.1.78-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007819 name: acyl-lysine deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate." [EC:3.5.1.17] synonym: "6-N-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17] synonym: "epsilon-lysine acylase activity" EXACT [EC:3.5.1.17] synonym: "N6-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17] xref: EC:3.5.1.17 xref: GO:0050477 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007820 name: anthranilate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + anthranilate + (tetrahydrobiopterin/tetrahydropteridine) = 3-hydroxanthranilate + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.3, MetaCyc:ANTHRANILATE-3-MONOOXYGENASE-RXN] synonym: "anthranilate 3-hydroxylase activity" EXACT [] synonym: "anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.3] synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.16.3] synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.16.3] xref: EC:1.14.16.3 xref: GO:0050478 xref: MetaCyc:ANTHRANILATE-3-MONOOXYGENASE-RXN is_a: CCO:F0003297 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007821 name: glyceryl-ether monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN] synonym: "1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity" EXACT [EC:1.14.16.5] synonym: "alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5] synonym: "glyceryl ether oxygenase activity" EXACT [EC:1.14.16.5] synonym: "glyceryl etherase activity" EXACT [EC:1.14.16.5] synonym: "glyceryl-ether cleaving enzyme activity" EXACT [EC:1.14.16.5] synonym: "O-alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5] xref: EC:1.14.16.5 xref: GO:0050479 xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN is_a: CCO:F0003297 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007822 name: imidazolonepropionase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = H+ + N-formimidoyl-L-glutamate." [EC:3.5.2.7, MetaCyc:IMIDAZOLONEPROPIONASE-RXN] subset: gosubset_prok synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity" EXACT [EC:3.5.2.7] synonym: "4(5)-imidazolone-5(4)-propionic acid hydrolase activity" EXACT [EC:3.5.2.7] synonym: "imidazolone propionic acid hydrolase activity" EXACT [EC:3.5.2.7] synonym: "imidazolone-5-propionate hydrolase activity" EXACT [EC:3.5.2.7] xref: EC:3.5.2.7 xref: GO:0050480 xref: MetaCyc:IMIDAZOLONEPROPIONASE-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0007823 name: mandelate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + O2 + (tetrahydrobiopterin/tetrahydropteridine) = (S)-4-hydroxymandelate + H2O + (dihydrobiopterin/dihydropteridine). (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate." [EC:1.14.16.6, MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN] synonym: "(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.6] synonym: "L-mandelate 4-hydroxylase activity" EXACT [] synonym: "mandelic acid 4-hydroxylase activity" EXACT [EC:1.14.16.6] xref: EC:1.14.16.6 xref: GO:0050481 xref: MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN is_a: CCO:F0003297 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007824 name: IMP 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai] synonym: "IMP 5' nucleotidase activity" EXACT [] synonym: "IMP-GMP specific 5'-nucleotidase activity" NARROW [] xref: GO:0050483 is_a: CCO:F0001796 ! 5'-nucleotidase activity [Term] id: CCO:F0007825 name: GMP 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai] synonym: "GMP 5' nucleotidase activity" EXACT [] synonym: "IMP-GMP specific 5'-nucleotidase activity" NARROW [] xref: GO:0050484 is_a: CCO:F0001796 ! 5'-nucleotidase activity [Term] id: CCO:F0007826 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor" EXACT [] xref: EC:1.21.4 xref: GO:0050485 is_a: CCO:F0006306 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond [Term] id: CCO:F0007827 name: intramolecular transferase activity, transferring hydroxy groups namespace: molecular_function def: "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.4.4 xref: GO:0050486 is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0007828 name: sulfoacetaldehyde acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: SO3(2-) (sulfite) + acetyl phosphate = 2-sulfoacetaldehyde + phosphate." [EC:2.3.3.15] comment: Note that the enzyme sulfoacetaldehyde acetyltransferase also has sulfoacetaldehyde lyase activity (GO:0050312). subset: gosubset_prok synonym: "acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)" EXACT [EC:2.3.3.15] synonym: "sulphoacetaldehyde acetyltransferase activity" EXACT [] xref: EC:2.3.3.15 xref: GO:0050487 is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0007829 name: ecdysteroid UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid." [GOC:ai] synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED [] xref: GO:0050488 is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007830 name: ecdysteroid UDP-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate + ecdysteroid = UDP + glucuronosyl-ecdysteroid." [GOC:ai] synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED [] xref: GO:0050489 is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0007831 name: 1,4-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid." [EC:3.1.1.25, MetaCyc:1] synonym: "1,4-lactone hydroxyacylhydrolase activity" EXACT [EC:3.1.1.25] synonym: "gamma-lactonase activity" EXACT [EC:3.1.1.25] xref: EC:3.1.1.25 xref: GO:0050490 xref: MetaCyc:1 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007832 name: sulcatone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + sulcatol = NADH + H+ + sulcatone." [EC:1.1.1.260, MetaCyc:1.1.1.260-RXN] synonym: "sulcatol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.260] xref: EC:1.1.1.260 xref: GO:0050491 xref: MetaCyc:1.1.1.260-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007833 name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate." [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN] subset: gosubset_prok synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.261] xref: EC:1.1.1.261 xref: GO:0050492 xref: MetaCyc:1.1.1.261-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007834 name: transferase activity, transferring alkylthio groups namespace: molecular_function def: "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)." [GOC:ai] subset: gosubset_prok xref: EC:2.8.4 xref: GO:0050497 is_a: CCO:F0003354 ! transferase activity, transferring sulfur-containing groups [Term] id: CCO:F0007835 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated." [GOC:mah] subset: gosubset_prok xref: EC:1.14.20 xref: GO:0050498 is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007836 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H." [GOC:mah] subset: gosubset_prok xref: EC:1.20.1 xref: GO:0050499 is_a: CCO:F0004500 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: CCO:F0007837 name: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1,3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate." [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN] synonym: "1,3-b-galactosyl-N-acetylhexosamine phosphorylase activity" EXACT [] synonym: "beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" EXACT [EC:2.4.1.211] xref: EC:2.4.1.211 xref: GO:0050500 xref: MetaCyc:2.4.1.211-RXN is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0007838 name: hyaluronan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)](n) + 2n UDP." [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN] subset: gosubset_prok synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" EXACT [EC:2.4.1.212] synonym: "HAS activity" EXACT [EC:2.4.1.212] synonym: "seHAS" RELATED [EC:2.4.1.212] synonym: "spHAS" RELATED [EC:2.4.1.212] xref: EC:2.4.1.212 xref: GO:0050501 xref: MetaCyc:2.4.1.212-RXN is_a: CCO:F0001774 ! UDP-glycosyltransferase activity is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0007839 name: cis-zeatin O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + UDP." [EC:2.4.1.215, MetaCyc:2.4.1.215-RXN] synonym: "cis-zeatin O-b-D-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215] synonym: "UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215] xref: EC:2.4.1.215 xref: GO:0050502 xref: MetaCyc:2.4.1.215-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007840 name: trehalose 6-phosphate phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate." [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN] subset: gosubset_prok synonym: "trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.216] xref: EC:2.4.1.216 xref: GO:0050503 xref: MetaCyc:2.4.1.216-RXN is_a: CCO:F0001019 ! phosphorylase activity [Term] id: CCO:F0007841 name: mannosyl-3-phosphoglycerate synthase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate." [EC:2.4.1.217, MetaCyc:2.4.1.217-RXN] subset: gosubset_prok synonym: "GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.217] synonym: "MPG synthase activity" EXACT [EC:2.4.1.217] xref: EC:2.4.1.217 xref: GO:0050504 xref: MetaCyc:2.4.1.217-RXN is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0007842 name: hydroquinone glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydroquinone + UDP-D-glucose = hydroquinone-O-beta-D-glucopyranoside + UDP." [EC:2.4.1.218, MetaCyc:2.4.1.218-RXN] synonym: "arbutin synthase activity" EXACT [EC:2.4.1.218] synonym: "hydroquinone:O-glucosyltransferase activity" EXACT [EC:2.4.1.218] synonym: "UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218] synonym: "UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218] xref: EC:2.4.1.218 xref: GO:0050505 xref: MetaCyc:2.4.1.218-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007843 name: vomilenine glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: vomilenine + UDP-D-glucose = raucaffricine + UDP." [EC:2.4.1.219, MetaCyc:2.4.1.219-RXN] synonym: "UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] synonym: "UDPG:vomilenine 21-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] synonym: "UDPG:vomilenine 21beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] synonym: "vomilenine-glucosyltransferase activity" EXACT [EC:2.4.1.219] xref: EC:2.4.1.219 xref: GO:0050506 xref: MetaCyc:2.4.1.219-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007844 name: indoxyl-UDPG glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indoxyl + UDP-D-glucose = indican + UDP." [EC:2.4.1.220, MetaCyc:2.4.1.220-RXN] synonym: "indoxyl-UDPG-glucosyltransferase activity" EXACT [EC:2.4.1.220] synonym: "UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.220] xref: EC:2.4.1.220 xref: GO:0050507 xref: MetaCyc:2.4.1.220-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007845 name: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN] synonym: "alpha-N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.224] synonym: "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224] xref: EC:2.4.1.224 xref: GO:0050508 xref: MetaCyc:2.4.1.224-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0007846 name: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN] synonym: "heparan glucuronyltransferase II activity" EXACT [EC:2.4.1.225] synonym: "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity" EXACT [] synonym: "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity" EXACT [EC:2.4.1.225] synonym: "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.225] xref: EC:2.4.1.225 xref: GO:0050509 xref: MetaCyc:2.4.1.225-RXN is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0007847 name: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN] synonym: "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.226] synonym: "chondroitin glucuronyltransferase II activity" EXACT [EC:2.4.1.226] synonym: "N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity" EXACT [] xref: EC:2.4.1.226 xref: GO:0050510 xref: MetaCyc:2.4.1.226-RXN is_a: CCO:F0002526 ! glucuronosyltransferase activity [Term] id: CCO:F0007848 name: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP." [EC:2.4.1.227, MetaCyc:2.4.1.227-RXN] subset: gosubset_prok synonym: "MurG transferase activity" RELATED [EC:2.4.1.227] synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity" EXACT [EC:2.4.1.227] synonym: "UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity" EXACT [EC:2.4.1.227] synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.227] synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT [] xref: EC:2.4.1.227 xref: GO:0050511 xref: MetaCyc:2.4.1.227-RXN is_a: CCO:F0001851 ! acetylglucosaminyltransferase activity [Term] id: CCO:F0007849 name: lactosylceramide 4-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN] synonym: "Gal-beta-1-4Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228] synonym: "galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228] synonym: "globotriaosylceramide/CD77 synthase activity" NARROW [EC:2.4.1.228] synonym: "histo-blood group P(k) UDP-galactose activity" NARROW [EC:2.4.1.228] synonym: "histo-blood group Pk UDP-galactose" RELATED [EC:2.4.1.228] synonym: "lactosylceramide 4-a-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.228] xref: EC:2.4.1.228 xref: GO:0050512 xref: MetaCyc:2.4.1.228-RXN is_a: CCO:F0005579 ! UDP-galactosyltransferase activity [Term] id: CCO:F0007850 name: glycoprotein 2-beta-D-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP-L-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP." [EC:2.4.2.38, MetaCyc:2.4.2.38-RXN] synonym: "beta-1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38] synonym: "beta1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38] synonym: "glycoprotein 2-b-D-xylosyltransferase activity" EXACT [] xref: EC:2.4.2.38 xref: GO:0050513 xref: MetaCyc:2.4.2.38-RXN is_a: CCO:F0005581 ! UDP-xylosyltransferase activity [Term] id: CCO:F0007851 name: homospermidine synthase (spermidine-specific) activity namespace: molecular_function def: "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine." [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN] synonym: "spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)" EXACT [EC:2.5.1.45] xref: EC:2.5.1.45 xref: GO:0050514 xref: MetaCyc:2.5.1.45-RXN is_a: CCO:F0003339 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: CCO:F0007852 name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol." [EC:2.7.1.148, MetaCyc:2.7.1.148-RXN] subset: gosubset_prok synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity" EXACT [EC:2.7.1.148] synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity" EXACT [] synonym: "ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity" EXACT [EC:2.7.1.148] synonym: "CDP-ME kinase activity" EXACT [EC:2.7.1.148] synonym: "CMK activity" RELATED [EC:2.7.1.148] xref: EC:2.7.1.148 xref: GO:0008698 xref: GO:0050515 xref: MetaCyc:2.7.1.148-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0007853 name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol." [EC:2.7.7.60, MetaCyc:2.7.7.60-RXN] subset: gosubset_prok synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity" EXACT [EC:2.7.7.60] synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity" EXACT [] synonym: "CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" EXACT [] synonym: "MCT activity" RELATED [EC:2.7.7.60] synonym: "MEP cytidylyltransferase activity" EXACT [] xref: EC:2.7.7.60 xref: GO:0008699 xref: GO:0050518 xref: MetaCyc:2.7.7.60-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0007854 name: holo-citrate lyase synthase activity namespace: molecular_function def: "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = pyrophosphate + holo-citrate lyase." [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN] subset: gosubset_prok synonym: "2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity" EXACT [EC:2.7.7.61] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity" EXACT [EC:2.7.7.61] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity" EXACT [EC:2.7.7.61] synonym: "CitX" RELATED [EC:2.7.7.61] synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61] xref: EC:2.7.7.61 xref: GO:0050519 xref: MetaCyc:2.7.7.61-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0007855 name: phosphatidylcholine synthase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + choline = CMP + phosphatidylcholine." [EC:2.7.8.24, MetaCyc:2.7.8.24-RXN] subset: gosubset_prok synonym: "CDP-diacylglycerol:choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] synonym: "CDP-diglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] synonym: "CDPdiglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] synonym: "PC synthase activity" EXACT [EC:2.7.8.24] xref: EC:2.7.8.24 xref: GO:0050520 xref: MetaCyc:2.7.8.24-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0007856 name: alpha-glucan, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate." [EC:2.7.9.4, MetaCyc:2.7.9.4-RXN] synonym: "a-glucan, water dikinase activity" EXACT [] synonym: "alpha-glucan,water dikinase activity" EXACT [EC:2.7.9.4] synonym: "ATP:alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.4] synonym: "GWD" RELATED [EC:2.7.9.4] synonym: "starch-related R1 protein activity" EXACT [EC:2.7.9.4] xref: EC:2.7.9.4 xref: GO:0050521 xref: MetaCyc:2.7.9.4-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003353 ! phosphotransferase activity, paired acceptors [Term] id: CCO:F0007857 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.20.98 xref: GO:0050522 is_a: CCO:F0004500 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: CCO:F0007858 name: coenzyme-B sulfoethylthiotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane. 2-(methylthio)ethanesulfonate is also known as methyl-CoM; N-(7-mercaptoheptanoyl)threonine 3-O-phosphate is also known as coenzyme B." [EC:2.8.4.1, MetaCyc:2.8.4.1-RXN] subset: gosubset_prok synonym: "2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity" EXACT [EC:2.8.4.1] synonym: "coenzyme-B sulphoethylthiotransferase activity" EXACT [] synonym: "methyl coenzyme M reductase activity" EXACT [EC:2.8.4.1] synonym: "methyl-CoM reductase activity" EXACT [EC:2.8.4.1] xref: EC:2.8.4.1 xref: GO:0050524 xref: MetaCyc:2.8.4.1-RXN is_a: CCO:F0007834 ! transferase activity, transferring alkylthio groups [Term] id: CCO:F0007859 name: cutinase activity namespace: molecular_function def: "Catalysis of the reaction: cutin + H2O = cutin monomers." [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN] subset: gosubset_prok synonym: "cutin hydrolase activity" EXACT [EC:3.1.1.74] xref: EC:3.1.1.74 xref: GO:0050525 xref: MetaCyc:3.1.1.74-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007860 name: poly(3-hydroxybutyrate) depolymerase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x = 1-5." [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN] subset: gosubset_prok synonym: "PHB depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.75] synonym: "poly(3HB) depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly(HA(SCL)) depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly(HA) depolymerase activity" RELATED [EC:3.1.1.75] synonym: "poly(HASCL) depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" EXACT [EC:3.1.1.75] synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75] xref: EC:3.1.1.75 xref: GO:0050526 xref: MetaCyc:3.1.1.75-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007861 name: poly(3-hydroxyoctanoate) depolymerase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x = 1-5." [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN] subset: gosubset_prok synonym: "PHA depolymerase activity" BROAD [EC:3.1.1.76] synonym: "PHO depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly((R)-3-hydroxyoctanoate) hydrolase activity" EXACT [EC:3.1.1.76] synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.76] synonym: "poly(3HO) depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly(HA(MCL)) depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly(HA) depolymerase activity" BROAD [EC:3.1.1.76] synonym: "poly(HAMCL) depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly[(R)-3-hydroxyoctanoate] hydrolase activity" EXACT [EC:3.1.1.76] synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.76] synonym: "poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity" EXACT [EC:3.1.1.76] xref: EC:3.1.1.76 xref: GO:0050527 xref: MetaCyc:3.1.1.76-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007862 name: acyloxyacyl hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN] xref: EC:3.1.1.77 xref: GO:0050528 xref: MetaCyc:3.1.1.77-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007863 name: polyneuridine-aldehyde esterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + polyneuridine aldehyde = methanol + CO2 + 16-epivellosimine." [EC:3.1.1.78, MetaCyc:3.1.1.78-RXN] synonym: "PNAE activity" EXACT [EC:3.1.1.78] synonym: "polyneuridine aldehyde esterase activity" EXACT [EC:3.1.1.78] synonym: "polyneuridine aldehyde hydrolase (decarboxylating)" EXACT [EC:3.1.1.78] xref: EC:3.1.1.78 xref: GO:0050529 xref: MetaCyc:3.1.1.78-RXN is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0007864 name: glucosylglycerol 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(beta-D-glucosyl)-sn-glycerol-3-phosphate + H2O = 2-(beta-D-glucosyl)-sn-glycerol + phosphate." [EC:3.1.3.69, MetaCyc:3.1.3.69-RXN] subset: gosubset_prok synonym: "2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.69] synonym: "salt tolerance protein A" RELATED [EC:3.1.3.69] synonym: "StpA" RELATED [EC:3.1.3.69] xref: EC:3.1.3.69 xref: GO:0050530 xref: MetaCyc:3.1.3.69-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007865 name: mannosyl-3-phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate." [EC:3.1.3.70, MetaCyc:3.1.3.70-RXN] subset: gosubset_prok synonym: "alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.70] xref: EC:3.1.3.70 xref: GO:0050531 xref: MetaCyc:3.1.3.70-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007866 name: 2-phosphosulfolactate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-3-sulfolactate + H2O = 3-sulfolactate + phosphate." [EC:3.1.3.71, MetaCyc:3.1.3.71-RXN] subset: gosubset_prok synonym: "(2R)-phosphosulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71] synonym: "(R)-2-phospho-3-sulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71] synonym: "2-phosphosulpholactate phosphatase activity" EXACT [] synonym: "ComB phosphatase activity" RELATED [EC:3.1.3.71] xref: EC:3.1.3.71 xref: GO:0050532 xref: MetaCyc:R229-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007867 name: 5-phytase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate." [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN] synonym: "myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.72] xref: EC:3.1.3.72 xref: GO:0050533 xref: MetaCyc:3.1.3.72-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0007868 name: 3-deoxyoctulosonase activity namespace: molecular_function def: "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide." [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN] synonym: "3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity" EXACT [EC:3.2.1.144] synonym: "alpha-Kdo-ase activity" EXACT [EC:3.2.1.144] xref: EC:3.2.1.144 xref: GO:0050534 xref: MetaCyc:3.2.1.144-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007869 name: beta-primeverosidase activity namespace: molecular_function def: "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol." [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN] synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity" EXACT [EC:3.2.1.149] synonym: "b-primeverosidase activity" EXACT [] xref: EC:3.2.1.149 xref: GO:0050535 xref: MetaCyc:3.2.1.149-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0007871 name: mandelamide amidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH3." [EC:3.5.1.86, MetaCyc:3.5.1.86-RXN] synonym: "mandelamide hydrolase activity" EXACT [EC:3.5.1.86] synonym: "Pseudomonas mandelamide hydrolase activity" EXACT [EC:3.5.1.86] xref: EC:3.5.1.86 xref: GO:0050537 xref: MetaCyc:3.5.1.86-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007872 name: N-carbamoyl-L-amino-acid hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-L-2-amino acid (a 2-ureido carboxylate) + H2O = L-2-amino acid + NH3 + CO2." [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN] subset: gosubset_prok synonym: "L-carbamoylase activity" EXACT [EC:3.5.1.87] synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" EXACT [EC:3.5.1.87] xref: EC:3.5.1.87 xref: GO:0050538 xref: MetaCyc:3.5.1.87-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007873 name: maleimide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: maleimide + H2O = maleamic acid." [EC:3.5.2.16, MetaCyc:3.5.2.16-RXN] synonym: "cyclic imide hydrolase activity" EXACT [EC:3.5.2.16] synonym: "cyclic-imide amidohydrolase (decyclicizing)" EXACT [EC:3.5.2.16] synonym: "cyclic-imide amidohydrolase (decyclizing)" EXACT [EC:3.5.2.16] synonym: "imidase activity" BROAD [EC:3.5.2.16] xref: EC:3.5.2.16 xref: GO:0050539 xref: MetaCyc:3.5.2.16-RXN is_a: CCO:F0003381 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: CCO:F0007874 name: 2-aminomuconate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminomuconate + H2O = 4-oxalocrotonate + NH3." [EC:3.5.99.5, MetaCyc:3.5.99.5-RXN] subset: gosubset_prok synonym: "2-aminomuconate aminohydrolase activity" EXACT [EC:3.5.99.5] xref: EC:3.5.99.5 xref: GO:0050540 xref: MetaCyc:3.5.99.5-RXN is_a: CCO:F0003379 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is_a: CCO:F0004140 ! deaminase activity [Term] id: CCO:F0007875 name: beta,beta-carotene-9',10'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone." [PMID:11278918] synonym: "b,b-carotene-9',10'-dioxygenase activity" EXACT [] xref: GO:0050541 is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0007876 name: icosanoid binding namespace: molecular_function def: "Interacting selectively with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "eicosanoid binding" EXACT [] xref: GO:0050542 is_a: CCO:F0001642 ! fatty acid binding [Term] id: CCO:F0007877 name: icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "eicosatetraenoic acid binding" EXACT [] xref: GO:0050543 is_a: CCO:F0007876 ! icosanoid binding [Term] id: CCO:F0007878 name: arachidonic acid binding namespace: molecular_function def: "Interacting selectively with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GOC:ai] synonym: "arachidonate binding" EXACT [] xref: GO:0050544 is_a: CCO:F0007877 ! icosatetraenoic acid binding [Term] id: CCO:F0007879 name: sulfopyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfopyruvate = 2-sulfoacetaldehyde + CO2." [EC:4.1.1.79, MetaCyc:4.1.1.79-RXN] subset: gosubset_prok synonym: "sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)" EXACT [EC:4.1.1.79] synonym: "sulfopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.79] synonym: "sulphopyruvate decarboxylase activity" EXACT [] xref: EC:4.1.1.79 xref: GO:0050545 xref: MetaCyc:R231-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007880 name: 4-hydroxyphenylpyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2." [EC:4.1.1.80, MetaCyc:4.1.1.80-RXN] synonym: "4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)" EXACT [EC:4.1.1.80] synonym: "4-hydroxyphenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.80] xref: EC:4.1.1.80 xref: GO:0050546 xref: MetaCyc:4.1.1.80-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007881 name: vanillin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA = vanillin + acetyl-CoA." [EC:4.1.2.41, MetaCyc:4.1.2.41-RXN] synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41] synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41] xref: EC:4.1.2.41 xref: GO:0050547 xref: MetaCyc:4.1.2.41-RXN is_a: CCO:F0003399 ! aldehyde-lyase activity [Term] id: CCO:F0007882 name: trans-feruloyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA." [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN] synonym: "4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)" EXACT [EC:4.2.1.101] synonym: "trans-feruloyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.101] xref: EC:4.2.1.101 xref: GO:0050548 xref: MetaCyc:4.2.1.101-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007883 name: cyclohexyl-isocyanide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: N-cyclohexylformamide = cyclohexyl isocyanide + H2O." [EC:4.2.1.103, MetaCyc:4.2.1.103-RXN] subset: gosubset_prok synonym: "isonitrile hydratase activity" EXACT [EC:4.2.1.103] synonym: "N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)" EXACT [EC:4.2.1.103] synonym: "N-cyclohexylformamide hydro-lyase activity" EXACT [EC:4.2.1.103] xref: EC:4.2.1.103 xref: GO:0050549 xref: MetaCyc:4.2.1.103-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0007884 name: pinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate." [EC:4.2.3.14, MetaCyc:4.2.3.14-RXN] synonym: "(-)-(1S,5S)-pinene synthase activity" EXACT [EC:4.2.3.14] synonym: "beta-geraniolene synthase activity" EXACT [EC:4.2.3.14] synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)" EXACT [EC:4.2.3.14] synonym: "geranyldiphosphate diphosphate lyase (pinene forming)" EXACT [EC:4.2.3.14] xref: EC:4.2.3.14 xref: GO:0050550 xref: MetaCyc:4.2.3.14-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0007885 name: myrcene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = myrcene + diphosphate." [EC:4.2.3.15, MetaCyc:4.2.3.15-RXN] synonym: "geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity" EXACT [] xref: EC:4.2.3.15 xref: GO:0050551 xref: MetaCyc:RXN-5110 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0007887 name: taxadiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate." [EC:4.2.3.17, MetaCyc:4.2.3.17-RXN] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)" EXACT [EC:4.2.3.17] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)" EXACT [EC:4.2.3.17] synonym: "taxa-4(5),11(12)-diene synthase activity" EXACT [EC:4.2.3.17] xref: EC:4.2.3.17 xref: GO:0050553 xref: MetaCyc:4.2.3.17-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0007888 name: abietadiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate." [EC:4.2.3.18, MetaCyc:4.2.3.18-RXN] synonym: "(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)" EXACT [EC:4.2.3.18] synonym: "abietadiene cyclase activity" EXACT [EC:4.2.3.18] synonym: "copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.18] xref: EC:4.2.3.18 xref: GO:0050554 xref: MetaCyc:4.2.3.18-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0007889 name: 2-hydroxypropyl-CoM lyase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-[or (S)-]2-hydroxypropyl-CoM = H-S-CoM + (R)-[or (S)-]1,2-epoxypropane." [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN] subset: gosubset_prok synonym: "(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] synonym: "(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] synonym: "2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] synonym: "coenzyme M-epoxyalkane ligase activity" EXACT [EC:4.4.1.23] synonym: "EaCoMT activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkane:2-mercaptoethanesulfonate transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkane:coenzyme M transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkane:CoM transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkyl:CoM transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxypropane:coenzyme M transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxypropyl:CoM transferase activity" EXACT [EC:4.4.1.23] xref: EC:4.4.1.23 xref: GO:0050555 xref: MetaCyc:4.2.99.19-RXN is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0007890 name: deacetylisoipecoside synthase activity namespace: molecular_function def: "Catalysis of the reaction: dopamine + secologanin = deacetylisoipecoside + H2O." [EC:4.3.3.3, MetaCyc:4.3.3.3-RXN] synonym: "deacetylisoipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.3] synonym: "deacetylisoipecoside dopamine-lyase activity" EXACT [EC:4.3.3.3] xref: EC:4.3.3.3 xref: GO:0050556 xref: MetaCyc:4.3.3.3-RXN is_a: CCO:F0003408 ! amine-lyase activity [Term] id: CCO:F0007891 name: deacetylipecoside synthase activity namespace: molecular_function def: "Catalysis of the reaction: dopamine + secologanin = deacetylipecoside + H2O." [EC:4.3.3.4, MetaCyc:4.3.3.4-RXN] synonym: "deacetylipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.4] synonym: "deacetylipecoside dopamine-lyase activity" EXACT [EC:4.3.3.4] xref: EC:4.3.3.4 xref: GO:0050557 xref: MetaCyc:4.3.3.4-RXN is_a: CCO:F0003408 ! amine-lyase activity [Term] id: CCO:F0007892 name: maltose epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-maltose = beta-maltose." [EC:5.1.3.21, MetaCyc:5.1.3.21-RXN] synonym: "maltose 1-epimerase activity" EXACT [EC:5.1.3.21] xref: EC:5.1.3.21 xref: GO:0050558 xref: MetaCyc:5.1.3.21-RXN is_a: CCO:F0003420 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: CCO:F0007893 name: copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = (+)-copalyl diphosphate." [EC:5.5.1.12, MetaCyc:5.5.1.12-RXN] synonym: "(+)-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.12] synonym: "diterpene cyclase activity" BROAD [] xref: EC:5.5.1.12 xref: GO:0050559 xref: MetaCyc:5.5.1.12-RXN is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0007894 name: aspartate-tRNA(Asn) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + pyrophosphate + AMP." [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN] synonym: "aspartate-tRNAAsn ligase activity" EXACT [] synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" EXACT [EC:6.1.1.23] synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23] xref: EC:6.1.1.23 xref: GO:0050560 xref: MetaCyc:6.1.1.23-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0007895 name: glutamate-tRNA(Gln) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + pyrophosphate + AMP." [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN] synonym: "glutamate-tRNAGln ligase activity" EXACT [] synonym: "L-glutamate:tRNAGlx ligase (AMP-forming)" EXACT [EC:6.1.1.24] synonym: "nondiscriminating glutamyl-tRNA synthetase activity" RELATED [EC:6.1.1.24] xref: EC:6.1.1.24 xref: GO:0050561 xref: MetaCyc:6.1.1.24-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0007896 name: lysine-tRNA(Pyl) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + pyrophosphate + AMP." [EC:6.1.1.25, MetaCyc:6.1.1.25-RXN] synonym: "L-lysine:tRNAPyl ligase (AMP-forming)" EXACT [EC:6.1.1.25] synonym: "lysine-tRNAPyl ligase activity" EXACT [] xref: EC:6.1.1.25 xref: GO:0050562 xref: MetaCyc:6.1.1.25-RXN is_a: CCO:F0001170 ! aminoacyl-tRNA ligase activity [Term] id: CCO:F0007897 name: trans-feruloyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown." [EC:6.2.1.34, MetaCyc:6.2.1.34-RXN] synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" EXACT [EC:6.2.1.34] synonym: "trans-feruloyl-CoA synthetase activity" EXACT [EC:6.2.1.34] xref: EC:6.2.1.34 xref: GO:0050563 xref: MetaCyc:6.2.1.34-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0007898 name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminohexanedioate + L-cysteine + L-valine + 3 ATP + H2O = N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate." [EC:6.3.2.26, MetaCyc:6.3.2.26-RXN] subset: gosubset_prok synonym: "ACV synthetase activity" BROAD [EC:6.3.2.26] synonym: "L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)" EXACT [EC:6.3.2.26] synonym: "L-alpha-aminoadipyl-cysteinyl-valine synthetase activity" EXACT [EC:6.3.2.26] synonym: "L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity" EXACT [EC:6.3.2.26] xref: EC:6.3.2.26 xref: GO:0050564 xref: MetaCyc:6.3.2.26-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0007899 name: aerobactin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4 ATP + citrate + N6-acetyl-N6-hydroxylysine = 4 ADP + 4 phosphate + aerobactin." [EC:6.3.2.27, MetaCyc:6.3.2.27-RXN] synonym: "citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27] synonym: "citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27] xref: EC:6.3.2.27 xref: GO:0050565 xref: MetaCyc:6.3.2.27-RXN is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0007900 name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP." [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN] synonym: "Asp-AdT activity" EXACT [EC:6.3.5.6] synonym: "Asp-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "Asp-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6] synonym: "asparaginyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.6] synonym: "aspartyl-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "aspartyl-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6] xref: EC:6.3.5.6 xref: GO:0050566 xref: MetaCyc:6.3.5.6-RXN is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0007901 name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] subset: gosubset_prok synonym: "Glu-AdT activity" EXACT [EC:6.3.5.-] synonym: "glu-tRNA(gln) amidotransferase activity" EXACT [EC:6.3.5.-] synonym: "Glu-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-] synonym: "Glu-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7] synonym: "Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7] synonym: "glutaminyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.7] synonym: "glutamyl-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-] synonym: "glutamyl-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7] synonym: "glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7] xref: EC:6.3.5.- xref: EC:6.3.5.7 xref: GO:0008264 xref: GO:0017068 xref: GO:0050567 xref: MetaCyc:6.3.5.7-RXN is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0007902 name: protein-glutamine glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3." [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN] synonym: "destabilase activity" EXACT [EC:3.5.1.44] synonym: "glutaminyl-peptide glutaminase activity" EXACT [EC:3.5.1.44] synonym: "glutaminylpeptide glutaminase activity" EXACT [EC:3.5.1.44] synonym: "peptidoglutaminase II activity" RELATED [EC:3.5.1.44] synonym: "peptidylglutaminase II" RELATED [EC:3.5.1.44] synonym: "protein-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.44] xref: EC:3.5.1.44 xref: GO:0050568 xref: MetaCyc:CHEBDEAMID-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0007903 name: glycolaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycolaldehyde + NAD+ + H2O = glycolate + NADH + H+." [EC:1.1.1.262, EC:1.2.1.21, MetaCyc:1.1.1.262-RXN, MetaCyc:GLYCOLALD-DEHYDROG-RXN] subset: gosubset_prok synonym: "glycol aldehyde dehydrogenase activity" EXACT [EC:1.2.1.21] synonym: "glycolaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.21] xref: EC:1.2.1.21 xref: GO:0050569 xref: MetaCyc:GLYCOLALD-DEHYDROG-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007904 name: 4-hydroxythreonine-4-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+." [EC:1.1.1.262, MetaCyc:1.1.1.262-RXN] subset: gosubset_prok synonym: "4-(phosphohydroxy)-L-threonine dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.262] synonym: "L-threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "NAD(+)-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "NAD+-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "PdxA" RELATED [EC:1.1.1.262] xref: EC:1.1.1.262 xref: GO:0050570 xref: MetaCyc:1.1.1.262-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007905 name: 1,5-anhydro-D-fructose reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+." [EC:1.1.1.263, MetaCyc:1.1.1.263-RXN] synonym: "1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.263] synonym: "AF reductase activity" EXACT [EC:1.1.1.263] xref: EC:1.1.1.263 xref: GO:0050571 xref: MetaCyc:1.1.1.263-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007906 name: L-idonate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+." [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN] subset: gosubset_prok synonym: "L-idonate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.264] xref: EC:1.1.1.264 xref: GO:0050572 xref: MetaCyc:1.1.1.264-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007907 name: dTDP-4-dehydro-6-deoxyglucose reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+." [EC:1.1.1.266, MetaCyc:1.1.1.266-RXN] synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.1.1.266] synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.266] xref: EC:1.1.1.266 xref: GO:0050573 xref: MetaCyc:1.1.1.266-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007908 name: 2-(R)-hydroxypropyl-CoM dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(R)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+." [EC:1.1.1.268, MetaCyc:1.1.1.268-RXN] subset: gosubset_prok synonym: "2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.268] synonym: "2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.268] xref: EC:1.1.1.268 xref: GO:0050574 xref: MetaCyc:1.1.1.268-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007909 name: 2-(S)-hydroxypropyl-CoM dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(S)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+." [EC:1.1.1.269, MetaCyc:1.1.1.269-RXN] subset: gosubset_prok synonym: "2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.269] synonym: "2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.269] xref: EC:1.1.1.269 xref: GO:0050575 xref: MetaCyc:1.1.1.269-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007910 name: 3-keto-steroid reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholest-7-en-3-one + NADPH + H+." [EC:1.1.1.270, MetaCyc:1.1.1.270-RXN] synonym: "3-KSR activity" EXACT [EC:1.1.1.270] synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] xref: EC:1.1.1.270 xref: GO:0050576 xref: MetaCyc:1.1.1.270-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007911 name: GDP-L-fucose synthase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN] subset: gosubset_prok synonym: "GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity" EXACT [EC:1.1.1.271] synonym: "GDP-fucose synthetase activity" EXACT [EC:1.1.1.271] synonym: "GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)" EXACT [EC:1.1.1.271] xref: EC:1.1.1.271 xref: GO:0050577 xref: MetaCyc:1.1.1.271-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007913 name: vellosimine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+." [EC:1.1.1.273, MetaCyc:1.1.1.273-RXN] synonym: "10-deoxysarpagine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.273] xref: EC:1.1.1.273 xref: GO:0050579 xref: MetaCyc:1.1.1.273-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007914 name: 2,5-didehydrogluconate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+." [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN] subset: gosubset_prok synonym: "2,5-diketo-D-gluconate reductase activity" EXACT [EC:1.1.1.274] synonym: "2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.274] synonym: "YqhE reductase" RELATED [EC:1.1.1.274] xref: EC:1.1.1.274 xref: GO:0050580 xref: MetaCyc:1.1.1.274-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007915 name: D-mannitol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: mannitol + O2 = mannose + H2O2." [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN] synonym: "D-arabinitol oxidase activity" RELATED [EC:1.1.3.40] synonym: "D-arabitol oxidase activity" EXACT [EC:1.1.3.40] synonym: "mannitol oxidase activity" EXACT [EC:1.1.3.40] synonym: "mannitol:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.1.3.40] xref: EC:1.1.3.40 xref: GO:0050581 xref: MetaCyc:1.1.3.40-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007916 name: xylitol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: xylitol + O2 = xylose + H2O2." [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN] subset: gosubset_prok synonym: "xylitol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.41] xref: EC:1.1.3.41 xref: GO:0050582 xref: MetaCyc:1.1.3.41-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0007917 name: hydrogen dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + H2 = NADPH + H+." [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN] synonym: "hydrogen:NADP+ oxidoreductase activity" EXACT [EC:1.12.1.3] synonym: "NADP-linked hydrogenase activity" RELATED [EC:1.12.1.3] synonym: "NADP-reducing hydrogenase activity" RELATED [EC:1.12.1.3] xref: EC:1.12.1.3 xref: GO:0050583 xref: MetaCyc:1.12.1.3-RXN is_a: CCO:F0003282 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor [Term] id: CCO:F0007918 name: linoleate 11-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate." [EC:1.13.11.45, MetaCyc:1.13.11.45-RXN] synonym: "linoleate dioxygenase activity" EXACT [EC:1.13.11.45] synonym: "linoleate:oxygen 11S-oxidoreductase activity" EXACT [EC:1.13.11.45] synonym: "manganese lipoxygenase activity" EXACT [EC:1.13.11.45] xref: EC:1.13.11.45 xref: GO:0050584 xref: MetaCyc:1.13.11.45-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007919 name: 4-hydroxymandelate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2." [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN] synonym: "4-hydroxyphenylpyruvate dioxygenase II activity" NARROW [EC:1.13.11.46] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.13.11.46] xref: EC:1.13.11.46 xref: GO:0050585 xref: MetaCyc:1.13.11.46-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007920 name: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = N-acetylanthranilate + CO." [EC:1.13.11.48, MetaCyc:1.13.11.48-RXN] subset: gosubset_prok synonym: "(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [EC:1.13.11.48] synonym: "1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity" EXACT [] synonym: "1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [] synonym: "3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.48] synonym: "3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity" EXACT [] xref: EC:1.13.11.48 xref: GO:0050586 xref: MetaCyc:1.13.11.48-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007921 name: chlorite O2-lyase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + Cl- = chlorite." [EC:1.13.11.49, MetaCyc:1.13.11.49-RXN] synonym: "chloride:oxygen oxidoreductase activity" EXACT [EC:1.13.11.49] synonym: "chlorite dismutase activity" EXACT [EC:1.13.11.49] xref: EC:1.13.11.49 xref: GO:0030065 xref: GO:0050587 xref: MetaCyc:1.13.11.49-RXN is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0007922 name: apo-beta-carotenoid-14',13'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = 14'-apo-beta-carotenal + H2O." [EC:1.13.12.12, MetaCyc:1.13.12.12-RXN] synonym: "8'-apo-beta-carotenol:O2 oxidoreductase activity" EXACT [EC:1.13.12.12] synonym: "apo-b-carotenoid-14',13'-dioxygenase activity" EXACT [] xref: EC:1.13.12.12 xref: GO:0050588 xref: MetaCyc:1.13.12.12-RXN is_a: CCO:F0003287 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: CCO:F0007923 name: leucocyanidin oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O." [EC:1.14.11.19, MetaCyc:1.14.11.19-RXN] synonym: "anthocyanidin synthase activity" RELATED [EC:1.14.11.19] synonym: "leucoanthocyanidin dioxygenase activity" EXACT [EC:1.14.11.19] synonym: "leucoanthocyanidin hydroxylase" RELATED [EC:1.14.11.19] synonym: "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.19] xref: EC:1.14.11.19 xref: GO:0045432 xref: GO:0050589 xref: MetaCyc:RXN-602 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors is_a: CCO:F0008070 ! dioxygenase activity [Term] id: CCO:F0007924 name: desacetoxyvindoline 4-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2." [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN] synonym: "D17H activity" RELATED [EC:1.14.11.20] synonym: "deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20] synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity" EXACT [EC:1.14.11.20] synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20] synonym: "desacetoxyvindoline-4-hydroxylase activity" EXACT [EC:1.14.11.20] synonym: "desacetyoxyvindoline-17-hydroxylase activity" EXACT [EC:1.14.11.20] xref: EC:1.14.11.20 xref: GO:0050590 xref: MetaCyc:1.14.11.20-RXN is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: CCO:F0007925 name: quinine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: quinine + NADPH + H+ + O2 = 3-hydroxyquinine + NADP+ + H2O." [EC:1.14.13.67, MetaCyc:1.14.13.67-RXN] synonym: "nifedipine oxidase activity" EXACT [EC:1.14.13.67] synonym: "quinine 3-hydroxylase activity" EXACT [] synonym: "quinine,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.67] xref: EC:1.14.13.67 xref: GO:0050591 xref: MetaCyc:1.14.13.67-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007926 name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetaldehyde oxime + NADPH + H+ + O2 = 4-hydroxymandelonitrile + NADP+ + 2 H2O." [EC:1.14.13.68, MetaCyc:1.14.13.68-RXN] synonym: "(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68] synonym: "4-hydroxybenzeneacetaldehyde oxime monooxygenase activity" EXACT [EC:1.14.13.68] synonym: "4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68] synonym: "CYP71E1 activity" NARROW [EC:1.14.13.68] synonym: "cytochrome P450-II-dependent monooxygenase activity" NARROW [EC:1.14.13.68] synonym: "cytochrome P450II-dependent monooxygenase activity" EXACT [EC:1.14.13.68] synonym: "NADPH-cytochrome P450 reductase (CYP71E1)" EXACT [EC:1.14.13.68] xref: EC:1.14.13.68 xref: GO:0050592 xref: MetaCyc:1.14.13.68-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007927 name: N-methylcoclaurine 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-N-methylcoclaurine + NADPH + H+ + O2 = (S)-3'-hydroxy-N-methylcoclaurine + NADP+ + H2O." [EC:1.14.13.71, MetaCyc:1.14.13.71-RXN] synonym: "(S)-N-methylcoclaurine 3'-hydroxylase activity" EXACT [EC:1.14.13.71] synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.71] synonym: "cytochrome P450 80B1 activity" EXACT [EC:1.14.13.71] synonym: "N-methylcoclaurine 3'-hydroxylase activity" EXACT [] xref: EC:1.14.13.71 xref: GO:0050593 xref: MetaCyc:1.14.13.71-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007928 name: tabersonine 16-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tabersonine + NADPH + H+ + O2 = 16-hydroxytabersonine + NADP+ + H2O." [EC:1.14.13.73, MetaCyc:1.14.13.73-RXN] synonym: "tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)" EXACT [EC:1.14.13.73] xref: EC:1.14.13.73 xref: GO:0050594 xref: MetaCyc:1.14.13.73-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007929 name: 7-deoxyloganin 7-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O." [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN] synonym: "7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.74] xref: EC:1.14.13.74 xref: GO:0050595 xref: MetaCyc:1.14.13.74-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007930 name: vinorine hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: vinorine + NADPH + H+ + O2 = vomilenine + NADP+ + H2O." [EC:1.14.13.75, MetaCyc:1.14.13.75-RXN] synonym: "vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)" EXACT [EC:1.14.13.75] xref: EC:1.14.13.75 xref: GO:0050596 xref: MetaCyc:1.14.13.75-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007931 name: taxane 10-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + taxa-4(20),11-dien-5-alpha-yl acetate = H2O + NADP+ + 10-beta-hydroxytaxa-4(20),11-dien-5-alpha-yl acetate." [EC:1.14.13.76, MetaCyc:1.14.13.76-RXN] synonym: "5-alpha-taxadienol-10-beta-hydroxylase activity" EXACT [EC:1.14.13.76] synonym: "taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)" EXACT [EC:1.14.13.76] synonym: "taxane 10b-hydroxylase activity" EXACT [] synonym: "taxane 10beta-hydroxylase activity" EXACT [EC:1.14.13.76] xref: EC:1.14.13.76 xref: GO:0050597 xref: MetaCyc:1.14.13.76-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007932 name: taxane 13-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + taxa-4(20),11-dien-5-alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5-alpha,13-alpha-diol." [EC:1.14.13.77, MetaCyc:1.14.13.77-RXN] synonym: "taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)" EXACT [EC:1.14.13.77] synonym: "taxane 13a-hydroxylase activity" EXACT [] synonym: "taxane 13alpha-hydroxylase activity" EXACT [EC:1.14.13.77] xref: EC:1.14.13.77 xref: GO:0050598 xref: MetaCyc:1.14.13.77-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0007933 name: deacetoxycephalosporin-C synthase activity namespace: molecular_function def: "Catalysis of the reaction: penicillin-N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O." [EC:1.14.20.1, MetaCyc:1.14.20.1-RXN] subset: gosubset_prok synonym: "DAOC synthase activity" EXACT [EC:1.14.20.1] synonym: "DAOCS activity" EXACT [EC:1.14.20.1] synonym: "penicillin N expandase activity" RELATED [EC:1.14.20.1] synonym: "penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)" EXACT [EC:1.14.20.1] xref: EC:1.14.20.1 xref: GO:0050599 xref: MetaCyc:1.14.20.1-RXN is_a: CCO:F0007835 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated [Term] id: CCO:F0007934 name: myristoyl-CoA 11-(E) desaturase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.31, MetaCyc:1.14.99.31-RXN] synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31] synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31] xref: EC:1.14.99.31 xref: GO:0050600 xref: MetaCyc:1.14.99.31-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007935 name: myristoyl-CoA 11-(Z) desaturase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.32, MetaCyc:1.14.99.32-RXN] synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32] synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32] xref: EC:1.14.99.32 xref: GO:0050601 xref: MetaCyc:1.14.99.32-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007936 name: monoprenyl isoflavone epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives." [EC:1.14.99.34, MetaCyc:1.14.99.34-RXN] synonym: "7-O-methylluteone,NADPH:O2 oxidoreductase activity" EXACT [EC:1.14.99.34] synonym: "7-O-methylluteone:O2 oxidoreductase activity" EXACT [EC:1.14.99.34] synonym: "monoprenyl isoflavone monooxygenase activity" EXACT [EC:1.14.99.34] xref: EC:1.14.99.34 xref: GO:0050602 xref: MetaCyc:1.14.99.34-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007937 name: thiophene-2-carbonyl-CoA monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: thiophene-2-carbonyl-CoA + AH2 + O2 = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O." [EC:1.14.99.35, MetaCyc:1.14.99.35-RXN] synonym: "thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.35] synonym: "thiophene-2-carboxyl-CoA dehydrogenase activity" EXACT [EC:1.14.99.35] synonym: "thiophene-2-carboxyl-CoA hydroxylase activity" EXACT [EC:1.14.99.35] synonym: "thiophene-2-carboxyl-CoA monooxygenase activity" EXACT [EC:1.14.99.35] xref: EC:1.14.99.35 xref: GO:0050603 xref: MetaCyc:1.14.99.35-RXN is_a: CCO:F0000894 ! monooxygenase activity is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007938 name: taxadiene 5-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + donor-H2 + taxa-4,11-diene = H2O + acceptor + taxa-4(20),11-dien-5-alpha-ol." [EC:1.14.99.37, MetaCyc:1.14.99.37-RXN] synonym: "taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)" EXACT [EC:1.14.99.37] synonym: "taxadiene 5a-hydroxylase activity" EXACT [] synonym: "taxadiene 5alpha-hydroxylase activity" EXACT [EC:1.14.99.37] xref: EC:1.14.99.37 xref: GO:0050604 xref: MetaCyc:1.14.99.37-RXN is_a: CCO:F0003288 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: CCO:F0007939 name: superoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: O2(-) + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin." [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN] subset: gosubset_prok synonym: "desulfoferrodoxin activity" RELATED [EC:1.15.1.2] synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2] synonym: "rubredoxin:superoxide oxidoreductase activity" EXACT [EC:1.15.1.2] xref: EC:1.15.1.2 xref: GO:0050605 xref: MetaCyc:1.15.1.2-RXN is_a: CCO:F0003303 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: CCO:F0007940 name: 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ = 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + H+." [EC:1.2.1.45, MetaCyc:1.2.1.45-RXN] synonym: "2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.45] synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase activity" EXACT [EC:1.2.1.45] synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.45] synonym: "alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.45] xref: EC:1.2.1.45 xref: GO:0050606 xref: MetaCyc:1.2.1.45-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007941 name: mycothiol-dependent formaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+." [EC:1.2.1.66, MetaCyc:1.2.1.66-RXN] subset: gosubset_prok synonym: "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT [EC:1.2.1.66] synonym: "NAD/factor-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.2.1.66] xref: EC:1.2.1.66 xref: GO:0050607 xref: MetaCyc:1.2.1.66-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007942 name: vanillin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: vanillin + NAD+ + H2O = vanillate + NADH + H+." [EC:1.2.1.67, MetaCyc:1.2.1.67-RXN] synonym: "vanillin:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.67] xref: EC:1.2.1.67 xref: GO:0050608 xref: MetaCyc:1.2.1.67-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007943 name: phosphonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: phosphonate + NAD+ + H2O = phosphate + NADH + H+." [EC:1.20.1.1, MetaCyc:1.20.1.1-RXN] subset: gosubset_prok synonym: "NAD-dependent phosphite dehydrogenas activity" EXACT [EC:1.20.1.1] synonym: "NAD:phosphite oxidoreductase activity" EXACT [EC:1.20.1.1] synonym: "phosphite dehydrogenase activity" EXACT [EC:1.20.1.1] synonym: "phosphonate:NAD+ oxidoreductase activity" EXACT [EC:1.20.1.1] xref: EC:1.20.1.1 xref: GO:0050609 xref: MetaCyc:1.20.1.1-RXN is_a: CCO:F0007836 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor [Term] id: CCO:F0007944 name: methylarsonate reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced glutathione + methylarsonate = oxidized glutathione + methylarsonite." [EC:1.20.4.2, MetaCyc:1.20.4.2-RXN] synonym: "gluthathione:methylarsonate oxidoreductase activity" EXACT [EC:1.20.4.2] synonym: "MMA(V) reductase activity" EXACT [EC:1.20.4.2] xref: EC:1.20.4.2 xref: GO:0050610 xref: MetaCyc:1.20.4.2-RXN is_a: CCO:F0004501 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor [Term] id: CCO:F0007945 name: arsenate reductase (azurin) activity namespace: molecular_function def: "Catalysis of the reaction: azurin(ox) + H2O + arsenite = azurin(red) + arsenate." [EC:1.20.98.1, MetaCyc:1.20.98.1-RXN] subset: gosubset_prok synonym: "arsenite:azurin oxidoreductase activity" EXACT [EC:1.20.98.1] xref: EC:1.20.98.1 xref: GO:0050611 xref: MetaCyc:1.20.98.1-RXN is_a: CCO:F0007857 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors [Term] id: CCO:F0007946 name: arsenate reductase (donor) activity namespace: molecular_function def: "Catalysis of the reaction: acceptor + arsenite = donor-H2 + arsenate." [EC:1.20.99.1, MetaCyc:1.20.99.1-RXN] synonym: "arsenate:(acceptor) oxidoreductase activity" EXACT [EC:1.20.99.1] synonym: "arsenate:acceptor oxidoreductase activity" EXACT [EC:1.20.99.1] xref: EC:1.20.99.1 xref: GO:0050612 xref: MetaCyc:1.20.99.1-RXN is_a: CCO:F0004500 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: CCO:F0007947 name: delta14-sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity" EXACT [EC:1.3.1.70] synonym: "C-14 sterol reductase activity" EXACT [] synonym: "D14-sterol reductase activity" EXACT [] synonym: "sterol C-14 reductase activity" EXACT [] synonym: "sterol C14-reductase activity" EXACT [EC:1.3.1.70] xref: EC:1.3.1.70 xref: GO:0000251 xref: GO:0050613 xref: MetaCyc:1.3.1.70-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007948 name: delta24-sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol." [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN] synonym: "D24-sterol reductase activity" EXACT [] synonym: "lanosterol Delta(24)-reductase activity" NARROW [EC:1.3.1.72] synonym: "lanosterol delta24-reductase activity" EXACT [EC:1.3.1.72] synonym: "sterol:NADP+ delta24-oxidoreductase activity" EXACT [EC:1.3.1.72] xref: EC:1.3.1.72 xref: GO:0050614 xref: MetaCyc:1.3.1.72-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007949 name: 1,2-dihydrovomilenine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + NADPH + H+." [EC:1.3.1.73, MetaCyc:1.3.1.73-RXN] synonym: "17-O-acetylnorajmaline:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.73] xref: EC:1.3.1.73 xref: GO:0050615 xref: MetaCyc:1.3.1.73-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007950 name: secologanin synthase activity namespace: molecular_function def: "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O." [EC:1.3.3.9, MetaCyc:1.3.3.9-RXN] synonym: "loganin:oxygen oxidoreductase (ring-cleaving)" EXACT [EC:1.3.3.9] xref: EC:1.3.3.9 xref: GO:0050616 xref: MetaCyc:1.3.3.9-RXN is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0007951 name: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN] subset: gosubset_prok synonym: "PebA" RELATED [EC:1.3.7.2] xref: EC:1.3.7.2 xref: GO:0050617 xref: MetaCyc:1.3.7.2-RXN is_a: CCO:F0003237 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0007952 name: phycoerythrobilin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin." [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN] subset: gosubset_prok synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.3] synonym: "PebB" RELATED [EC:1.3.7.3] xref: EC:1.3.7.3 xref: GO:0050618 xref: MetaCyc:1.3.7.3-RXN is_a: CCO:F0003237 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0007953 name: phytochromobilin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN] synonym: "(3Z)-phytochromobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.4] synonym: "HY2" RELATED [EC:1.3.7.4] synonym: "P-Phi-B synthase activity" RELATED [EC:1.3.7.4] synonym: "PFB synthase activity" EXACT [EC:1.3.7.4] synonym: "phytochromobilin synthase activity" EXACT [EC:1.3.7.4] synonym: "PPhiB synthase activity" EXACT [EC:1.3.7.4] xref: EC:1.3.7.4 xref: GO:0050619 xref: MetaCyc:1.3.7.4-RXN is_a: CCO:F0003237 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0007954 name: phycocyanobilin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN] subset: gosubset_prok synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.5] xref: EC:1.3.7.5 xref: GO:0050620 xref: MetaCyc:1.3.7.5-RXN is_a: CCO:F0003237 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0007955 name: tryptophan alpha,beta-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2." [EC:1.3.3.10, MetaCyc:1.4.3.17-RXN] comment: Note that this was EC:1.4.3.17. synonym: "L-tryptophan 2',3'-oxidase activity" EXACT [EC:1.3.3.10] synonym: "L-tryptophan alpha,beta-dehydrogenase activity" EXACT [EC:1.3.3.10] synonym: "L-tryptophan:oxygen alpha,beta-oxidoreductase activity" EXACT [EC:1.3.3.10] synonym: "tryptophan a,b-oxidase activity" EXACT [] xref: EC:1.3.3.10 xref: GO:0050621 xref: MetaCyc:1.4.3.17-RXN is_a: CCO:F0003235 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: CCO:F0007956 name: glycine dehydrogenase (cyanide-forming) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2." [EC:1.4.99.5, MetaCyc:1.4.99.5-RXN] synonym: "glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)" EXACT [EC:1.4.99.5] synonym: "HCN synthase activity" EXACT [EC:1.4.99.5] synonym: "hydrogen cyanide synthase activity" EXACT [EC:1.4.99.5] xref: EC:1.4.99.5 xref: GO:0050622 xref: MetaCyc:1.4.99.5-RXN is_a: CCO:F0003238 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: CCO:F0007957 name: berberine reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+." [EC:1.5.1.31, MetaCyc:1.5.1.31-RXN] synonym: "(R)-canadine synthase activity" EXACT [EC:1.5.1.31] synonym: "(R)-tetrahydroberberine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.31] xref: EC:1.5.1.31 xref: GO:0050623 xref: MetaCyc:1.5.1.31-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007958 name: vomilenine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP+ = vomilenine + NADPH + H+." [EC:1.5.1.32, MetaCyc:1.5.1.32-RXN] synonym: "1,2-dihydrovomilenine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.32] xref: EC:1.5.1.32 xref: GO:0050624 xref: MetaCyc:1.5.1.32-RXN is_a: CCO:F0003245 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007959 name: 2-hydroxy-1,4-benzoquinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + NADH + H+ = NAD+ + 1,2,4-benzenetriol." [EC:1.6.5.7, MetaCyc:1.6.5.7-RXN] synonym: "1,2,4-trihydroxybenzene:NAD oxidoreductase activity" EXACT [EC:1.6.5.7] synonym: "1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity" EXACT [EC:1.6.5.7] synonym: "2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity" EXACT [EC:1.6.5.7] synonym: "hydroxybenzoquinone reductase activity" EXACT [EC:1.6.5.-] synonym: "NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.7] xref: EC:1.6.5.- xref: EC:1.6.5.7 xref: GO:0018540 xref: GO:0050625 xref: MetaCyc:1.6.5.7-RXN xref: UM-BBD_enzymeID:e0424 is_a: CCO:F0003253 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: CCO:F0007960 name: trimethylamine-N-oxide reductase (cytochrome c) activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+ ." [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN] subset: gosubset_prok synonym: "TMAO reductase activity" EXACT [EC:1.7.2.3] synonym: "TOR activity" EXACT [EC:1.7.2.3] synonym: "trimethylamine:cytochrome c oxidoreductase activity" EXACT [EC:1.7.2.3] xref: EC:1.7.2.3 xref: GO:0050626 xref: MetaCyc:1.7.2.3-RXN is_a: CCO:F0003257 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: CCO:F0007961 name: mycothione reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione." [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN] synonym: "mycothiol-disulfide reductase activity" EXACT [EC:1.8.1.15] synonym: "mycothiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.15] xref: EC:1.8.1.15 xref: GO:0050627 xref: MetaCyc:1.8.1.15-RXN is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007962 name: 2-oxopropyl-CoM reductase (carboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+." [EC:1.8.1.5, MetaCyc:1.8.1.5-RXN] subset: gosubset_prok synonym: "2-KPCC activity" EXACT [EC:1.8.1.5] synonym: "2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.8.1.5] synonym: "NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5] synonym: "NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5] xref: EC:1.8.1.5 xref: GO:0050628 xref: MetaCyc:1.8.1.5-RXN is_a: CCO:F0003261 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: CCO:F0007963 name: tetrachloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor." [EC:1.97.1.8, MetaCyc:1.97.1.8-RXN] subset: gosubset_prok synonym: "acceptor:trichloroethene oxidoreductase (chlorinating)" EXACT [EC:1.97.1.8] synonym: "tetrachloroethene reductase activity" EXACT [EC:1.97.1.8] xref: EC:1.97.1.8 xref: GO:0050629 xref: MetaCyc:1.97.1.8-RXN is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0007965 name: corydaline synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ = S-adenosyl-L-homocysteine + corydaline + 2 NADP+." [EC:2.1.1.147, MetaCyc:2.1.1.147-RXN] synonym: "S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity" EXACT [EC:2.1.1.147] xref: EC:2.1.1.147 xref: GO:0050631 xref: MetaCyc:2.1.1.147-RXN is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0007966 name: propionyl-CoA C2-trimethyltridecanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." [EC:2.3.1.154, MetaCyc:2.3.1.154-RXN] synonym: "3-oxopristanoyl-CoA hydrolase activity" EXACT [EC:2.3.1.154] synonym: "3-oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154] synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154] synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154] synonym: "oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154] synonym: "peroxisomal 3-oxoacyl coenzyme A thiolase" NARROW [EC:2.3.1.154] synonym: "peroxisome sterol carrier protein thiolase" NARROW [EC:2.3.1.154] synonym: "propionyl-CoA C(2)-trimethyltridecanoyltransferase activity" EXACT [] synonym: "SCPx" RELATED [EC:2.3.1.154] synonym: "sterol carrier protein" RELATED [EC:2.3.1.154] xref: EC:2.3.1.154 xref: GO:0050632 xref: MetaCyc:2.3.1.154-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007967 name: acetyl-CoA C-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA." [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN] synonym: "3-oxopalmitoyl-CoA hydrolase activity" EXACT [EC:2.3.1.155] synonym: "3-oxopalmitoyl-CoA-CoA acetyltransferase activity" EXACT [EC:2.3.1.155] synonym: "myristoyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.155] synonym: "myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity" EXACT [EC:2.3.1.155] xref: EC:2.3.1.155 xref: GO:0050633 xref: MetaCyc:2.3.1.155-RXN is_a: CCO:F0003131 ! C-acyltransferase activity is_a: CCO:F0004053 ! myristoyltransferase activity [Term] id: CCO:F0007968 name: phloroisovalerophenone synthase activity namespace: molecular_function def: "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one." [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN] synonym: "3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity" EXACT [EC:2.3.1.156] synonym: "isovaleryl-CoA:malonyl-CoA acyltransferase activity" EXACT [EC:2.3.1.156] synonym: "valerophenone synthase activity" EXACT [EC:2.3.1.156] xref: EC:2.3.1.156 xref: GO:0050634 xref: MetaCyc:2.3.1.156-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007969 name: acridone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2." [EC:2.3.1.159, MetaCyc:2.3.1.159-RXN] synonym: "malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.159] xref: EC:2.3.1.159 xref: GO:0050635 xref: MetaCyc:2.3.1.159-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007970 name: vinorine synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 16-epivellosimine = CoA + vinorine." [EC:2.3.1.160, MetaCyc:2.3.1.160-RXN] synonym: "acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)" EXACT [EC:2.3.1.160] xref: EC:2.3.1.160 xref: GO:0050636 xref: MetaCyc:2.3.1.160-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007971 name: lovastatin nonaketide synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O." [EC:2.3.1.161, MetaCyc:2.3.1.161-RXN] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)" EXACT [EC:2.3.1.161] xref: EC:2.3.1.161 xref: GO:0050637 xref: MetaCyc:2.3.1.161-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007972 name: taxadien-5-alpha-ol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5-alpha-ol = CoA + taxa-4(20),11-dien-5-alpha-yl acetate." [EC:2.3.1.162, MetaCyc:2.3.1.162-RXN] synonym: "acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162] synonym: "acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162] synonym: "acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162] synonym: "taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity" EXACT [EC:2.3.1.162] synonym: "taxadien-5a-ol O-acetyltransferase activity" EXACT [] synonym: "taxadien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162] synonym: "taxadienol acetyltransferase activity" EXACT [EC:2.3.1.162] xref: EC:2.3.1.162 xref: GO:0050638 xref: MetaCyc:2.3.1.162-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0007973 name: 10-hydroxytaxane O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C." [EC:2.3.1.163, MetaCyc:2.3.1.163-RXN] synonym: "acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163] synonym: "acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163] synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.163] xref: EC:2.3.1.163 xref: GO:0050639 xref: MetaCyc:2.3.1.163-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0007974 name: isopenicillin-N N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin-N + H2O = CoA + penicillin-G + L-2-aminohexanedioate." [EC:2.3.1.164, MetaCyc:2.3.1.164-RXN] synonym: "acyl-CoA:isopenicillin N N-acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "acyl-coenzyme A:isopenicillin N acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "isopenicillin N:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "isopenicillin-N acyltransferase activity" EXACT [] xref: EC:2.3.1.164 xref: GO:0042319 xref: GO:0045440 xref: GO:0050640 xref: MetaCyc:2.3.1.164-RXN is_a: CCO:F0003133 ! N-acyltransferase activity [Term] id: CCO:F0007975 name: 6-methylsalicylic acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+." [EC:2.3.1.165, MetaCyc:2.3.1.165-RXN] synonym: "6-MSAS activity" EXACT [EC:2.3.1.165] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)" EXACT [EC:2.3.1.165] synonym: "MSAS activity" EXACT [EC:2.3.1.165] xref: EC:2.3.1.165 xref: GO:0050641 xref: MetaCyc:2.3.1.165-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007976 name: 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III." [EC:2.3.1.166, MetaCyc:2.3.1.166-RXN] synonym: "2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity" EXACT [EC:2.3.1.166] synonym: "2a-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [] synonym: "2alpha-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] synonym: "benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity" EXACT [EC:2.3.1.166] synonym: "benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] synonym: "benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] xref: EC:2.3.1.166 xref: GO:0050642 xref: MetaCyc:2.3.1.166-RXN is_a: CCO:F0003322 ! transferase activity, transferring groups other than amino-acyl groups [Term] id: CCO:F0007977 name: 10-deacetylbaccatin III 10-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III." [EC:2.3.1.167, MetaCyc:2.3.1.167-RXN] synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.167] xref: EC:2.3.1.167 xref: GO:0050643 xref: MetaCyc:2.3.1.167-RXN is_a: CCO:F0003136 ! O-acetyltransferase activity [Term] id: CCO:F0007978 name: cis-p-coumarate glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cis-p-coumarate + UDP-D-glucose = UDP + 4'-O-beta-D-glucosyl-cis-p-coumarate." [EC:2.4.1.209, MetaCyc:2.4.1.209-RXN] synonym: "UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.209] xref: EC:2.4.1.209 xref: GO:0050644 xref: MetaCyc:2.4.1.209-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007979 name: limonoid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP." [EC:2.4.1.210] synonym: "LGTase activity" EXACT [EC:2.4.1.210] synonym: "limonoid UDP-glucosyltransferase activity" EXACT [EC:2.4.1.210] synonym: "uridine diphosphoglucose-limonoid glucosyltransferase activity" EXACT [EC:2.4.1.210] xref: EC:2.4.1.210 xref: GO:0050645 xref: MetaCyc:2.4.1.210-RXN is_a: CCO:F0005580 ! UDP-glucosyltransferase activity [Term] id: CCO:F0007980 name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] xref: GO:0050646 is_a: CCO:F0007877 ! icosatetraenoic acid binding [Term] id: CCO:F0007981 name: 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] xref: GO:0050647 is_a: CCO:F0007877 ! icosatetraenoic acid binding [Term] id: CCO:F0007982 name: 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] xref: GO:0050648 is_a: CCO:F0007877 ! icosatetraenoic acid binding [Term] id: CCO:F0007983 name: testosterone 6-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O." [GOC:ai, PMID:11726664] synonym: "testosterone 6b-hydroxylase activity" EXACT [] xref: GO:0050649 is_a: CCO:F0001866 ! steroid hydroxylase activity [Term] id: CCO:F0007984 name: 3'-phosphoadenosine 5'-phosphosulfate binding namespace: molecular_function def: "Interacting selectively with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [GOC:ai] synonym: "3'-phosphoadenosine 5'-phosphosulphate binding" EXACT [] synonym: "3'-phosphoadenylyl-sulfate binding" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate binding" EXACT [] synonym: "PAPS binding" EXACT [] synonym: "phosphoadenosine phosphosulfate binding" EXACT [] xref: GO:0050656 is_a: CCO:F0004466 ! adenyl nucleotide binding [Term] id: CCO:F0007985 name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.33] synonym: "3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity" EXACT [EC:2.8.2.33] synonym: "GalNAc4S-6ST" RELATED [EC:2.8.2.33] synonym: "N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity" EXACT [EC:2.8.2.33] xref: EC:2.8.2.33 xref: GO:0050659 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007986 name: FAD binding namespace: molecular_function def: "Interacting selectively with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "flavin adenine dinucleotide binding" EXACT [] synonym: "flavine-adenine dinucleotide binding" EXACT [] xref: GO:0050660 is_a: CCO:F0004466 ! adenyl nucleotide binding is_a: CCO:F0007988 ! coenzyme binding [Term] id: CCO:F0007987 name: NADP binding namespace: molecular_function def: "Interacting selectively with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH." [GOC:ai] synonym: "NADP (oxidized) binding" EXACT [] synonym: "NADP (reduced) binding" EXACT [] synonym: "NADPH binding" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT [] synonym: "oxidized NADP binding" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate binding" EXACT [] synonym: "reduced NADP binding" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate binding" EXACT [] xref: GO:0050661 is_a: CCO:F0007988 ! coenzyme binding [Term] id: CCO:F0007988 name: coenzyme binding namespace: molecular_function def: "Interacting selectively with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: GO:0050662 is_a: CCO:F0007309 ! cofactor binding [Term] id: CCO:F0007989 name: oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-] xref: EC:1.6.3 xref: GO:0050664 is_a: CCO:F0003249 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: CCO:F0007990 name: androgen receptor binding namespace: molecular_function def: "Interacting selectively with an androgen receptor." [GOC:ai] synonym: "AR binding" EXACT [] xref: GO:0050681 is_a: CCO:F0005586 ! steroid hormone receptor binding [Term] id: CCO:F0007991 name: AF-2 domain binding namespace: molecular_function def: "Interacting selectively with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation." [PMID:9682036] xref: GO:0050682 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0007992 name: AF-1 domain binding namespace: molecular_function def: "Interacting selectively with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor." [PMID:9682036] xref: GO:0050683 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0007993 name: DBD domain binding namespace: molecular_function def: "Interacting selectively with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors." [PMID:9682036] synonym: "DNA binding domain binding" EXACT [] xref: GO:0050692 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0007994 name: LBD domain binding namespace: molecular_function def: "Interacting selectively with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." [PMID:9682036] synonym: "ligand binding domain binding" EXACT [] xref: GO:0050693 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0007995 name: galactose 3-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc." [GOC:ai, PMID:11323440, PMID:11356829] synonym: "Gal-3-O-sulfotransferase activity" EXACT [] synonym: "galactose 3-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0050694 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007996 name: benzoylformate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2." [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "benzoylformate carboxy-lyase (benzaldehyde-forming)" EXACT [EC:4.1.1.7] synonym: "benzoylformate carboxy-lyase activity" EXACT [EC:4.1.1.7] synonym: "phenylglyoxylate decarboxylase activity" EXACT [] xref: EC:4.1.1.7 xref: GO:0050695 xref: MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN is_a: CCO:F0003398 ! carboxy-lyase activity [Term] id: CCO:F0007997 name: 1,1,2-trichloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene." [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271] synonym: "1,1,2-trichloroethylene reductive dehalogenase activity" EXACT [] synonym: "TCE-reductive dehalogenase activity" EXACT [] xref: GO:0050697 xref: MetaCyc:TCEREDCHLOR-RXN xref: UM-BBD_enzymeID:e0271 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0007998 name: proteoglycan sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans." [EC:2.8.2.-, GOC:ai] synonym: "proteoglycan sulfate transfer" RELATED [] synonym: "proteoglycan sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: GO:0050698 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0007999 name: WW domain binding namespace: molecular_function def: "Interacting selectively with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730] xref: GO:0050699 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0008000 name: CARD domain binding namespace: molecular_function def: "Interacting selectively with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670] xref: GO:0050700 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0008001 name: RS domain binding namespace: molecular_function def: "Interacting selectively with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing." [PMID:11684676, PMID:12215544] xref: GO:0050733 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0008002 name: hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule." [GOC:ai] xref: GO:0050734 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0008003 name: N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an malonyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: GO:0050735 is_a: CCO:F0003133 ! N-acyltransferase activity is_a: CCO:F0003143 ! malonyltransferase activity [Term] id: CCO:F0008004 name: O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an malonyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: GO:0050736 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0003143 ! malonyltransferase activity [Term] id: CCO:F0008005 name: O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: GO:0050737 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0008002 ! hydroxycinnamoyltransferase activity [Term] id: CCO:F0008006 name: fructosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] xref: GO:0050738 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0008007 name: apolipoprotein E receptor binding namespace: molecular_function def: "Interacting selectively with an apolipoprotein E receptor." [GOC:ai] xref: GO:0050749 is_a: CCO:F0005528 ! apolipoprotein receptor binding is_a: CCO:F0008008 ! low-density lipoprotein receptor binding [Term] id: CCO:F0008008 name: low-density lipoprotein receptor binding namespace: molecular_function def: "Interacting selectively with a low density lipoprotein receptor." [GOC:ai] synonym: "LDL receptor binding" EXACT [] xref: GO:0050750 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0008009 name: dopamine receptor binding namespace: molecular_function def: "Interacting selectively with a dopamine receptor." [GOC:ai] xref: GO:0050780 is_a: CCO:F0000196 ! G-protein-coupled receptor binding [Term] id: CCO:F0008010 name: ortho-trichlorophenol reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6-trichlorophenol +2 H+ + 2 e- = 2,4-dichlorophenol + HCl." [GOC:ai, PMID:12697029] subset: gosubset_prok synonym: "2,4,6-TCP reductive dehalogenase activity" EXACT [] synonym: "2,4,6-trichlorophenol reductive dehalogenase activity" EXACT [] xref: GO:0050781 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0008011 name: galactose uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6] synonym: "galactose, glucose uniporter activity" BROAD [] xref: GO:0050782 is_a: CCO:F0001580 ! galactose transmembrane transporter activity is_a: CCO:F0001969 ! hexose uniporter activity [Term] id: CCO:F0008012 name: advanced glycation end-product receptor activity namespace: molecular_function def: "Combining with advanced glycation end-products to initiate a change in cell activity." [PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812] synonym: "RAGE receptor activity" EXACT [] xref: GO:0050785 is_a: CCO:F0001226 ! receptor activity [Term] id: CCO:F0008013 name: RAGE receptor binding namespace: molecular_function def: "Interacting selectively with the RAGE receptor, the receptor for advanced glycation end-products." [GOC:ai] synonym: "advanced glycation end-product receptor binding" EXACT [] xref: GO:0050786 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0008014 name: thymidylate synthase (FAD) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + FADH2 = dTMP + tetrahydrofolate + FAD." [EC:2.1.1.148] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.148] synonym: "FDTS activity" EXACT [EC:2.1.1.148] synonym: "flavin dependent thymidylate synthase activity" EXACT [EC:2.1.1.148] synonym: "Thy1 activity" EXACT [] synonym: "ThyX activity" EXACT [] xref: EC:2.1.1.148 xref: GO:0050797 is_a: CCO:F0005619 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: CCO:F0008015 name: diazepam binding namespace: molecular_function def: "Interacting selectively with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "diazepam binding inhibitor activity" RELATED [] synonym: "Valium binding" EXACT [] xref: GO:0050809 is_a: CCO:F0001746 ! drug binding [Term] id: CCO:F0008016 name: GABA receptor binding namespace: molecular_function def: "Interacting selectively with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai] synonym: "4-aminobutanoate receptor binding" EXACT [] synonym: "4-aminobutyrate receptor binding" EXACT [] synonym: "diazepam binding inhibitor activity" RELATED [] synonym: "gamma-aminobutyric acid receptor binding" EXACT [] xref: GO:0050811 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0008017 name: phosphoserine binding namespace: molecular_function def: "Interacting selectively with a phosphorylated serine residue within a protein." [GOC:ai] synonym: "phosphoserine/phosphothreonine binding" BROAD [] xref: GO:0050815 is_a: CCO:F0006109 ! protein phosphorylated amino acid binding [Term] id: CCO:F0008018 name: phosphothreonine binding namespace: molecular_function def: "Interacting selectively with a phosphorylated threonine residue within a protein." [GOC:ai] synonym: "phosphoserine/phosphothreonine binding" BROAD [] xref: GO:0050816 is_a: CCO:F0006109 ! protein phosphorylated amino acid binding [Term] id: CCO:F0008019 name: water binding namespace: molecular_function def: "Interacting selectively with water (H2O)." [GOC:ai] subset: goslim_pir subset: gosubset_prok xref: GO:0050824 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0008020 name: ice binding namespace: molecular_function def: "Interacting selectively with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "antifreeze activity" RELATED [] synonym: "ice crystal binding" EXACT [] synonym: "ice nucleation activity" RELATED [] synonym: "ice nucleation inhibitor activity" RELATED [] xref: GO:0050825 is_a: CCO:F0008019 ! water binding [Term] id: CCO:F0008021 name: toxin receptor binding namespace: molecular_function def: "Interacting selectively with a toxin receptor, a receptor for substances that cause injury to living organisms." [GOC:ai] synonym: "channel-forming toxin activity" RELATED [] synonym: "cytotoxin activity" RELATED [] synonym: "endotoxin activity" RELATED [] synonym: "enterotoxin activity" RELATED [] synonym: "exotoxin activity" RELATED [] synonym: "lipoprotein toxin" RELATED [] synonym: "neurotoxin activity" RELATED [] synonym: "pore-forming toxin activity" RELATED [] synonym: "toxin activity" RELATED [] xref: GO:0050827 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0008022 name: pyruvate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] xref: GO:0050833 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0008023 name: cell adhesion molecule binding namespace: molecular_function def: "Interacting selectively with a cell adhesion molecule." [GOC:ai] synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "CAM binding" EXACT [] synonym: "cell adhesion molecule activity" RELATED [] synonym: "cell adhesion receptor activity" RELATED [] xref: GO:0050839 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0008024 name: extracellular matrix binding namespace: molecular_function def: "Interacting selectively with a component of the extracellular matrix." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "extracellular matrix constituent binding" EXACT [] xref: GO:0050840 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0008025 name: cobalt ion binding namespace: molecular_function def: "Interacting selectively with a cobalt (Co) ion." [GOC:ai] subset: gosubset_prok synonym: "cobalt binding" EXACT [] xref: GO:0050897 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0008026 name: quaternary ammonium group binding namespace: molecular_function def: "Interacting selectively with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai] subset: gosubset_prok synonym: "quaternary amine binding" EXACT [] xref: GO:0050997 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0008027 name: nitric-oxide synthase binding namespace: molecular_function def: "Interacting selectively with the enzyme nitric-oxide synthase." [GOC:ai] synonym: "NOS binding" EXACT [] xref: GO:0050998 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0008028 name: ligase activity, forming nitrogen-metal bonds namespace: molecular_function def: "Catalysis of the ligation of two substances via a nitrogen-metal bond." [EC:6.6.-.-] subset: gosubset_prok xref: EC:6.6 xref: GO:0051002 is_a: CCO:F0003433 ! ligase activity [Term] id: CCO:F0008029 name: ligase activity, forming nitrogen-metal bonds, forming coordination complexes namespace: molecular_function def: "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex." [EC:6.6.1.-] subset: gosubset_prok xref: EC:6.6.1 xref: GO:0051003 is_a: CCO:F0008028 ! ligase activity, forming nitrogen-metal bonds [Term] id: CCO:F0008030 name: squalene-hopene cyclase activity namespace: molecular_function def: "Catalysis of the reaction: squalene = hop-22(29)-ene." [EC:5.4.99.17] subset: gosubset_prok synonym: "squalene mutase (cyclizing)" EXACT [EC:5.4.99.17] synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99.17 xref: GO:0051007 is_a: CCO:F0003427 ! intramolecular transferase activity is_a: CCO:F0005516 ! squalene cyclase activity [Term] id: CCO:F0008031 name: Hsp27 protein binding namespace: molecular_function def: "Interacting selectively with Hsp27 proteins, a lightweight heat shock protein." [GOC:ai] xref: GO:0051008 is_a: CCO:F0004628 ! heat shock protein binding [Term] id: CCO:F0008032 name: O-acetylhomoserine sulfhydrylase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-homoserine + H2S = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN] xref: GO:0051009 xref: MetaCyc:ACETYLHOMOSER-CYS-RXN is_a: CCO:F0003401 ! carbon-oxygen lyase activity [Term] id: CCO:F0008033 name: microtubule plus-end binding namespace: molecular_function def: "Interacting selectively with the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] xref: GO:0051010 is_a: CCO:F0001679 ! microtubule binding [Term] id: CCO:F0008034 name: microtubule minus-end binding namespace: molecular_function def: "Interacting selectively with the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] xref: GO:0051011 is_a: CCO:F0001679 ! microtubule binding [Term] id: CCO:F0008035 name: actin filament binding namespace: molecular_function def: "Interacting selectively with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "actin cross-linking activity" RELATED [] synonym: "F-actin binding" EXACT [] xref: GO:0051015 is_a: CCO:F0000323 ! actin binding [Term] id: CCO:F0008036 name: protein kinase A binding namespace: molecular_function def: "Interacting selectively with any subunit of protein kinase A." [GOC:ai] comment: Note that this term is a direct child of 'protein binding ; GO:0005515' because it encompasses binding to either the catalytic or regulatory subunit of protein kinase A, and the latter does not have kinase activity. synonym: "PKA binding" EXACT [] synonym: "protein kinase A anchoring activity" RELATED [] xref: GO:0051018 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0008037 name: mitogen-activated protein kinase binding namespace: molecular_function def: "Interacting selectively with a mitogen-activated protein kinase." [GOC:ai] synonym: "MAP kinase binding" EXACT [] synonym: "MAP-kinase anchoring activity" RELATED [] synonym: "MAPK binding" EXACT [] xref: GO:0051019 is_a: CCO:F0004210 ! protein kinase binding [Term] id: CCO:F0008038 name: GTPase binding namespace: molecular_function def: "Interacting selectively with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] xref: GO:0051020 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0008039 name: GDP-dissociation inhibitor binding namespace: molecular_function def: "Interacting selectively with a GDP-dissociation inhibitor protein." [GOC:ai] synonym: "GDI binding" EXACT [] xref: GO:0051021 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0008040 name: Rho GDP-dissociation inhibitor binding namespace: molecular_function def: "Interacting selectively with a Rho GDP-dissociation inhibitor protein." [GOC:ai] synonym: "Rho GDI binding" EXACT [] xref: GO:0051022 is_a: CCO:F0008039 ! GDP-dissociation inhibitor binding [Term] id: CCO:F0008041 name: nucleic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai] xref: GO:0051032 is_a: CCO:F0003026 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: CCO:F0008042 name: RNA transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai] xref: GO:0051033 is_a: CCO:F0008041 ! nucleic acid transmembrane transporter activity [Term] id: CCO:F0008043 name: tRNA transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai] xref: GO:0051034 is_a: CCO:F0008042 ! RNA transmembrane transporter activity [Term] id: CCO:F0008044 name: DNA transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai] xref: GO:0051035 is_a: CCO:F0008041 ! nucleic acid transmembrane transporter activity [Term] id: CCO:F0008045 name: NF-kappaB binding namespace: molecular_function def: "Interacting selectively with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai] xref: GO:0051059 is_a: CCO:F0001738 ! transcription factor binding [Term] id: CCO:F0008046 name: pullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1,6)-a-D-glucosidic linkages in pullulan [a linear polymer of a-(1,6)-linked maltotriose units] and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen." [EC:3.2.1.41] subset: gosubset_prok synonym: "alpha-dextrin endo-1,6-alpha-glucosidase activity" EXACT [] synonym: "amylopectin 6-glucanohydrolase activity" EXACT [] synonym: "bacterial debranching enzyme" RELATED [EC:3.2.1.41] synonym: "debranching enzyme activity" BROAD [EC:3.2.1.41] synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.41] synonym: "pullulan 6-glucanohydrolase activity" EXACT [] synonym: "pullulan alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.41] synonym: "R-enzyme" RELATED [EC:3.2.1.41] xref: EC:3.2.1.41 xref: GO:0051060 is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0008047 name: ADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN] synonym: "ADP reduction" RELATED [] xref: GO:0051061 xref: MetaCyc:ADPREDUCT-RXN is_a: CCO:F0001113 ! ribonucleoside-diphosphate reductase activity [Term] id: CCO:F0008048 name: UDP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN] synonym: "UDP reduction" RELATED [] xref: GO:0051062 xref: MetaCyc:UDPREDUCT-RXN is_a: CCO:F0001113 ! ribonucleoside-diphosphate reductase activity [Term] id: CCO:F0008049 name: CDP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin." [MetaCyc:CDPREDUCT-RXN] synonym: "CDP reduction" RELATED [] xref: GO:0051063 xref: MetaCyc:CDPREDUCT-RXN is_a: CCO:F0001113 ! ribonucleoside-diphosphate reductase activity [Term] id: CCO:F0008050 name: TTP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] synonym: "TTP reduction" RELATED [] xref: EC:1.17.4.- xref: GO:0051064 is_a: CCO:F0002330 ! ribonucleoside-triphosphate reductase activity [Term] id: CCO:F0008051 name: CTP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] synonym: "CTP reduction" RELATED [] xref: EC:1.17.4.- xref: GO:0051065 is_a: CCO:F0002330 ! ribonucleoside-triphosphate reductase activity [Term] id: CCO:F0008052 name: adenosylcobinamide-GDP ribazoletransferase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin." [EC:2.7.8.26, MetaCyc:COBALAMINSYN-RXN] synonym: "adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity" EXACT [EC:2.7.8.26] synonym: "cobalamin (5'-phosphate) synthase activity" EXACT [EC:2.7.8.26] synonym: "cobalamin synthase activity" EXACT [] synonym: "cobalamin-5'-phosphate synthase activity" EXACT [EC:2.7.8.26] synonym: "CobS" RELATED [EC:2.7.8.26] xref: EC:2.7.8.26 xref: GO:0051073 xref: MetaCyc:COBALAMINSYN-RXN is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0008053 name: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA [preQ1-tRNA] = adenine + methionine + epoxyqueuosine-tRNA [oQ-tRNA]." [PMID:12731872] subset: gosubset_prok synonym: "S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity" EXACT [] xref: GO:0051075 is_a: CCO:F0003316 ! transferase activity is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0008054 name: Gram-positive bacterial binding namespace: molecular_function def: "Interacting selectively with any part of a Gram-positive bacterial cell." [GOC:ai] subset: gosubset_prok synonym: "binding to Gram-positive bacterium" EXACT [] synonym: "Gram-positive bacterium binding" EXACT [] xref: GO:0051076 is_a: CCO:F0001847 ! bacterial binding [Term] id: CCO:F0008055 name: unfolded protein binding namespace: molecular_function def: "Interacting selectively with an unfolded protein." [GOC:ai] subset: gosubset_prok synonym: "binding unfolded ER proteins" NARROW [] synonym: "chaperone activity" RELATED [] synonym: "fimbrium-specific chaperone activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "histone-specific chaperone activity" RELATED [] synonym: "ribosomal chaperone activity" RELATED [] synonym: "tubulin-specific chaperone activity" RELATED [] xref: GO:0051082 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0008056 name: chaperone binding namespace: molecular_function def: "Interacting selectively with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com] subset: gosubset_prok synonym: "chaperone protein binding" EXACT [] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] xref: GO:0051087 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0008057 name: carnitine-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA." [MetaCyc:DCARNCOALIG-RXN] synonym: "carnitine synthetase activity" EXACT [] synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] xref: GO:0051108 xref: MetaCyc:DCARNCOALIG-RXN is_a: CCO:F0003128 ! CoA-ligase activity is_a: CCO:F0003440 ! acid-amino acid ligase activity [Term] id: CCO:F0008058 name: crotonobetaine-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA." [MetaCyc:CROTCOALIG-RXN] synonym: "crotonobetaine-CoA synthase activity" EXACT [] synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] xref: GO:0051109 xref: MetaCyc:CROTCOALIG-RXN is_a: CCO:F0003128 ! CoA-ligase activity [Term] id: CCO:F0008059 name: cobaltochelatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + hydrogenobyrinic acid a,c-diamide + Co2+ = ADP + phosphate + cob(II)yrinic acid a,c-diamide + H+." [EC:6.6.1.2] subset: gosubset_prok synonym: "CobN-CobST" RELATED [EC:6.6.1.2] synonym: "CobNST" NARROW [] synonym: "hydrogenobyrinic acid a,c-diamide cobaltochelatase activity" EXACT [] synonym: "hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)" EXACT [EC:6.6.1.2] xref: EC:6.6.1.2 xref: GO:0051116 xref: MetaCyc:R342-RXN is_a: CCO:F0008029 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes [Term] id: CCO:F0008060 name: ATPase binding namespace: molecular_function def: "Interacting selectively with an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai] xref: GO:0051117 is_a: CCO:F0004208 ! enzyme binding [Term] id: CCO:F0008061 name: glucan endo-1,3-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." [EC:3.2.1.59] synonym: "1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.59] synonym: "cariogenanase activity" EXACT [EC:3.2.1.59] synonym: "cariogenase activity" EXACT [EC:3.2.1.59] synonym: "endo-(1->3)-alpha-glucanase activity" EXACT [EC:3.2.1.59] synonym: "endo-1,3-alpha-D-glucanase activity" EXACT [EC:3.2.1.59] synonym: "endo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.59] synonym: "mutanase activity" EXACT [EC:3.2.1.59] xref: EC:3.2.1.59 xref: GO:0051118 is_a: CCO:F0003021 ! glucosidase activity [Term] id: CCO:F0008062 name: sugar transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sugar/polyol channel activity" NARROW [] xref: GO:0051119 is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity [Term] id: CCO:F0008063 name: hepoxilin A3 synthase activity namespace: molecular_function def: "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid [12S-HpETE] = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate [hepoxilin A3]." [PMID:15123652] xref: GO:0051120 is_a: CCO:F0003416 ! isomerase activity [Term] id: CCO:F0008064 name: metal ion:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg] subset: gosubset_prok synonym: "metal ion:proton antiporter activity" EXACT [] xref: GO:0051139 is_a: CCO:F0002748 ! solute:hydrogen antiporter activity [Term] id: CCO:F0008065 name: vitamin transporter activity namespace: molecular_function def: "Enables the directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: gosubset_prok synonym: "vitamin or cofactor transporter activity" BROAD [] xref: GO:0051183 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0008066 name: cofactor transporter activity namespace: molecular_function def: "Enables the directed movement of a cofactor into, out of, within or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] subset: gosubset_prok synonym: "vitamin or cofactor transporter activity" BROAD [] xref: GO:0051184 is_a: CCO:F0001491 ! transporter activity [Term] id: CCO:F0008067 name: coenzyme transporter activity namespace: molecular_function def: "Enables the directed movement of a coenzyme into, out of, within or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] xref: GO:0051185 is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0008068 name: prosthetic group binding namespace: molecular_function def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules." [GOC:ai] subset: gosubset_prok xref: GO:0051192 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0008069 name: vanadium ion binding namespace: molecular_function def: "Interacting selectively with vanadium (V) ions." [GOC:ai] subset: gosubset_prok xref: GO:0051212 is_a: CCO:F0006268 ! transition metal ion binding [Term] id: CCO:F0008070 name: dioxygenase activity namespace: molecular_function def: "Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate." [http://www.onelook.com/] subset: goslim_pir subset: gosubset_prok xref: GO:0051213 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0008071 name: phosphoprotein binding namespace: molecular_function def: "Interacting selectively with a phosphorylated protein." [GOC:ai] synonym: "phosphorylated protein binding" EXACT [] xref: GO:0051219 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0008072 name: mono-olein transacylation activity namespace: molecular_function def: "Catalysis of the reaction: mono-olein (mono-oleoylglycerol) + mono-olein = diolein (dioleoylglycerol) + glycerol. Mono-olein is the monoglyceride formed from oleic acid, 9-octodecenoic acid." [GOC:ai, PMID:15364929] synonym: "acyl-CoA-independent mono-olein transacylation" EXACT [] synonym: "MOG transacylation" EXACT [] synonym: "mono-oleoylglycerol O-acyltransferase activity" EXACT [] synonym: "mono-oleoylglycerol transacylase activity" EXACT [] synonym: "monoolein transacylation" EXACT [] synonym: "monooleoylglycerol O-acyltransferase activity" EXACT [] synonym: "monooleoylglycerol transacylase activity" EXACT [] xref: GO:0051264 is_a: CCO:F0003134 ! acylglycerol O-acyltransferase activity [Term] id: CCO:F0008073 name: diolein transacylation activity namespace: molecular_function def: "Catalysis of the reaction: diolein (dioleoylglycerol) + mono-olein (mono-oleoylglycerol) = triolein (trioleoylglycerol) + glycerol. Mono-olein is the monoglyceride formed from oleic acid, 9-octodecenoic acid; triolein or trioleoylglycerol is also known as olein." [GOC:ai, PMID:15364929] synonym: "acyl-CoA-independent diolein transacylation" EXACT [] synonym: "dioleoylglycerol O-acyltransferase activity" EXACT [] synonym: "dioleoylglycerol transacylase activity" EXACT [] synonym: "DOG transacylation" EXACT [] xref: GO:0051265 is_a: CCO:F0003134 ! acylglycerol O-acyltransferase activity [Term] id: CCO:F0008074 name: sirohydrochlorin ferrochelatase activity namespace: molecular_function def: "Catalysis of the reaction: sirohydrochlorin + Fe2+ = siroheme + 2 H+." [EC:4.99.1.4, MetaCyc:SIROHEME-FERROCHELAT-RXN] subset: gosubset_prok synonym: "CysG" RELATED [EC:4.99.1.4] synonym: "Met8P" RELATED [EC:4.99.1.4] synonym: "SirB" RELATED [EC:4.99.1.4] synonym: "siroheme ferro-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.4] synonym: "siroheme synthase activity" BROAD [] synonym: "sirohydrochlorin ferro-lyase activity" EXACT [] xref: EC:4.99.1.4 xref: GO:0051266 xref: MetaCyc:SIROHEME-FERROCHELAT-RXN is_a: CCO:F0000745 ! ferrochelatase activity [Term] id: CCO:F0008075 name: CP2 mannose-ethanolamine phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine phosphate (EtN-P) + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2." [PMID:14985347, PMID:15452134] synonym: "addition of ethanolamine phosphate to mannose of GPI precursor CP2" EXACT [] synonym: "CP2 ethanolamine phosphate transferase activity" EXACT [] synonym: "CP2 EtN-P transferase activity" EXACT [] synonym: "CP2 phosphoethanolamine transferase activity" EXACT [] synonym: "gpi7 activity" RELATED [] xref: GO:0051267 is_a: CCO:F0008086 ! mannose-ethanolamine phosphotransferase activity [Term] id: CCO:F0008076 name: alpha-keto amide reductase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic." [GOC:ai, PMID:15564669] xref: EC:1.2.-.- xref: GO:0051268 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0008077 name: alpha-keto ester reductase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic." [GOC:ai, PMID:15564669] xref: EC:1.2.-.- xref: GO:0051269 is_a: CCO:F0003460 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: CCO:F0008078 name: NAD binding namespace: molecular_function def: "Interacting selectively with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH." [GOC:ai] synonym: "NAD (oxidized) binding" EXACT [] synonym: "NAD (reduced) binding" EXACT [] synonym: "NADH binding" EXACT [] synonym: "nicotinamide adenine dinucleotide binding" EXACT [] synonym: "oxidized NAD binding" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide binding" EXACT [] synonym: "reduced NAD binding" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide binding" EXACT [] xref: GO:0051287 xref: GO:0051288 is_a: CCO:F0007988 ! coenzyme binding [Term] id: CCO:F0008079 name: ZASP binding namespace: molecular_function def: "Interacting selectively with Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain." [PMID:10427098, PMID:11699871] synonym: "Z-band alternatively spliced PDZ-motif protein binding" EXACT [] xref: GO:0051370 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0008080 name: muscle alpha-actinin binding namespace: molecular_function def: "Interacting selectively with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165] synonym: "alpha-actinin 2 binding" NARROW [] synonym: "alpha-actinin 3 binding" NARROW [] xref: GO:0051371 is_a: CCO:F0008092 ! alpha-actinin binding [Term] id: CCO:F0008081 name: nonmuscle alpha-actinin binding namespace: molecular_function def: "Interacting selectively with nonmuscle isoforms of actinin. Nonmuscle alpha-actinin is found at the leading edge of motile cells, cell adhesion sites, focal contacts and along actin stress fibers in migrating cells." [PMID:15014165] synonym: "alpha-actinin 1 binding" NARROW [] synonym: "alpha-actinin 4 binding" EXACT [] xref: GO:0051372 is_a: CCO:F0008092 ! alpha-actinin binding [Term] id: CCO:F0008082 name: FATZ binding namespace: molecular_function def: "Interacting selectively with a family of FATZ proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871] synonym: "calsarcin binding" EXACT [] synonym: "filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle" EXACT [] xref: GO:0051373 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0008083 name: FATZ 1 binding namespace: molecular_function def: "Interacting selectively with FATZ 1, a protein of FATZ family that is highly expressed in skeletal muscle fast fiber." [PMID:10984498, PMID:11699871] synonym: "calsarcin 2 binding" EXACT [] xref: GO:0051374 is_a: CCO:F0008082 ! FATZ binding [Term] id: CCO:F0008084 name: FATZ 2 binding namespace: molecular_function def: "Interacting selectively with FATZ 2, a protein of the FATZ family that is highly expressed in skeletal muscle fiber fast IIa and slow I and in cardiac muscle." [PMID:10984498, PMID:11699871] synonym: "calsarcin 1 binding" EXACT [] xref: GO:0051375 is_a: CCO:F0008082 ! FATZ binding [Term] id: CCO:F0008085 name: FATZ 3 binding namespace: molecular_function def: "Interacting selectively with FATZ 3, a protein of the FATZ family that is highly expressed in skeletal muscle fast fiber." [PMID:10984498, PMID:11699871] synonym: "calsarcin 3 binding" EXACT [] xref: GO:0051376 is_a: CCO:F0008082 ! FATZ binding [Term] id: CCO:F0008086 name: mannose-ethanolamine phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136] synonym: "addition of ethanolamine phosphate to mannose of GPI precursor" EXACT [] synonym: "ethanolamine phosphate transferase activity" BROAD [] synonym: "EtN-P transferase activity" EXACT [] synonym: "phosphoethanolamine transferase activity" BROAD [] xref: GO:0051377 is_a: CCO:F0003352 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: CCO:F0008087 name: serotonin binding namespace: molecular_function def: "Interacting selectively with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai] synonym: "5-hydroxytryptamine binding" EXACT [] xref: GO:0051378 is_a: CCO:F0005633 ! neurotransmitter binding is_a: CCO:F0005682 ! hormone binding is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0008088 name: epinephrine binding namespace: molecular_function def: "Interacting selectively with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] synonym: "adrenaline binding" EXACT [] xref: GO:0051379 is_a: CCO:F0005633 ! neurotransmitter binding is_a: CCO:F0005682 ! hormone binding is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0008089 name: norepinephrine binding namespace: molecular_function def: "Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "noradrenaline binding" EXACT [] xref: GO:0051380 is_a: CCO:F0005633 ! neurotransmitter binding is_a: CCO:F0005682 ! hormone binding is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0008090 name: histamine binding namespace: molecular_function def: "Interacting selectively with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] xref: GO:0051381 is_a: CCO:F0005633 ! neurotransmitter binding is_a: CCO:F0005810 ! amine binding [Term] id: CCO:F0008091 name: tRNA N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA." [PMID:15037780] synonym: "tRNA cytidine N-acetyltransferase activity" EXACT [] xref: GO:0051392 is_a: CCO:F0001700 ! N-acetyltransferase activity [Term] id: CCO:F0008092 name: alpha-actinin binding namespace: molecular_function def: "Interacting selectively with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165] xref: GO:0051393 is_a: CCO:F0005715 ! actinin binding [Term] id: CCO:F0008093 name: N-terminal basic amino acid aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai] xref: GO:0051397 is_a: CCO:F0000646 ! aminopeptidase activity [Term] id: CCO:F0008094 name: N-terminal lysine aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] synonym: "lysine aminopeptidase activity" BROAD [] synonym: "lysyl aminopeptidase activity" BROAD [] xref: GO:0051398 is_a: CCO:F0008093 ! N-terminal basic amino acid aminopeptidase activity [Term] id: CCO:F0008095 name: N-terminal arginine aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] synonym: "arginine aminopeptidase activity" BROAD [] synonym: "argininyl aminopeptidase activity" BROAD [] xref: GO:0051399 is_a: CCO:F0008093 ! N-terminal basic amino acid aminopeptidase activity [Term] id: CCO:F0008096 name: BH domain binding namespace: molecular_function def: "Interacting selectively with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] synonym: "Bcl-2 homology domain binding" EXACT [] xref: GO:0051400 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0008097 name: CH domain binding namespace: molecular_function def: "Interacting selectively with the calponin homology domain of a protein, a domain of 100 residues that occurs in signaling and cytoskeletal proteins." [PMID:11911887, Prosite:PDOC50021] synonym: "calponin homology domain binding" EXACT [] xref: GO:0051401 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0008098 name: clostripain activity namespace: molecular_function def: "Catalysis of the cleavage of Arg-Xaa bonds." [EC:3.4.22.8] synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8] synonym: "clostridiopeptidase B activity" EXACT [] synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8] xref: EC:3.4.22.8 xref: GO:0051404 is_a: CCO:F0000666 ! cysteine-type endopeptidase activity [Term] id: CCO:F0008099 name: microbial collagenase activity namespace: molecular_function def: "Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." [EC:3.4.24.3] synonym: "Achromobacter iophagus collagenase" RELATED [EC:3.4.24.3] synonym: "aspergillopeptidase C" RELATED [EC:3.4.24.3] synonym: "azocollase activity" EXACT [EC:3.4.24.3] synonym: "clostridiopeptidase A activity" EXACT [] synonym: "clostridiopeptidase I" RELATED [EC:3.4.24.3] synonym: "clostridiopeptidase II" RELATED [EC:3.4.24.3] synonym: "Clostridium histolyticum collagenase activity" NARROW [EC:3.4.24.3] synonym: "Clostridium histolyticum proteinase A" RELATED [EC:3.4.24.3] synonym: "collagen peptidase activity" EXACT [EC:3.4.24.3] synonym: "collagen protease activity" EXACT [EC:3.4.24.3] synonym: "collagenase 1 activity" EXACT [] synonym: "collagenase A activity" EXACT [] synonym: "collagenase I activity" EXACT [EC:3.4.24.3] synonym: "collagenase MMP-1" RELATED [EC:3.4.24.3] synonym: "kollaza" RELATED [EC:3.4.24.3] synonym: "matirx metalloproteinase-18" RELATED [EC:3.4.24.3] synonym: "matrix metalloproteinase-1" RELATED [EC:3.4.24.3] synonym: "matrix metalloproteinase-8" RELATED [EC:3.4.24.3] synonym: "metallocollagenase activity" EXACT [EC:3.4.24.3] synonym: "metalloproteinase-1" RELATED [EC:3.4.24.3] synonym: "nucleolysin" RELATED [EC:3.4.24.3] synonym: "soycollagestin" RELATED [EC:3.4.24.3] xref: EC:3.4.24.3 xref: GO:0051405 is_a: CCO:F0001737 ! collagenase activity [Term] id: CCO:F0008100 name: beta-actinin binding namespace: molecular_function def: "Interacting selectively with beta-actinin, a heterodimeric actin-binding protein which caps the barbed end of actin filaments and nucleates actin polymerization in a calcium-independent manner. In myofibrils it is localized in the Z-lines." [PMID:11699871, PMID:2341404, PMID:9742448] synonym: "capZ binding" EXACT [] xref: GO:0051406 is_a: CCO:F0005715 ! actinin binding [Term] id: CCO:F0008101 name: glycerone phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)." [GOC:ai] synonym: "dihydroxyacetone-phosphate:inorganic phosphate antiporter activity" EXACT [] xref: GO:0051407 is_a: CCO:F0002761 ! organophosphate:inorganic phosphate antiporter activity [Term] id: CCO:F0008102 name: glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)." [GOC:ai] xref: GO:0051408 is_a: CCO:F0002761 ! organophosphate:inorganic phosphate antiporter activity [Term] id: CCO:F0008103 name: ALP binding namespace: molecular_function def: "Interacting selectively wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band." [PMID:11699871] synonym: "actinin-associated LIM protein binding" EXACT [] xref: GO:0051411 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0008104 name: myotilin binding namespace: molecular_function def: "Interacting selectively with myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C." [PMID:11699871, PMID:15752755] xref: GO:0051416 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0008105 name: nebulin binding namespace: molecular_function def: "Interacting selectively with nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone." [PMID:11699871] xref: GO:0051419 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0008106 name: nebulette binding namespace: molecular_function def: "Interacting selectively with nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin." [PMID:11699871] xref: GO:0051420 is_a: CCO:F0001705 ! cytoskeletal protein binding [Term] id: CCO:F0008107 name: corticotropin-releasing hormone binding namespace: molecular_function def: "Interacting selectively with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [http://www.onelook.com] synonym: "corticoliberin binding" EXACT [] synonym: "corticotropin-releasing factor binding" EXACT [] synonym: "CRH binding" EXACT [] xref: GO:0051424 is_a: CCO:F0003529 ! peptide hormone binding [Term] id: CCO:F0008108 name: PTB domain binding namespace: molecular_function def: "Interacting selectively with a phosphotyrosine-binding (PTB) domain of a protein." [Pfam:PF02174.5, PMID:15924411] synonym: "phosphotyrosine-interacting domain binding" EXACT [] synonym: "PID binding" BROAD [] xref: GO:0051425 is_a: CCO:F0004213 ! protein domain specific binding [Term] id: CCO:F0008109 name: hormone receptor binding namespace: molecular_function def: "Interacting selectively with a receptor for hormones." [GOC:ai] xref: GO:0051427 is_a: CCO:F0001407 ! receptor binding [Term] id: CCO:F0008110 name: peptide hormone receptor binding namespace: molecular_function def: "Interacting selectively with a receptor for peptide hormones." [GOC:ai] synonym: "polypeptide hormone receptor binding" EXACT [] xref: GO:0051428 is_a: CCO:F0008109 ! hormone receptor binding [Term] id: CCO:F0008111 name: corticotropin-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively with a receptor for corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [GOC:ai] xref: GO:0051429 is_a: CCO:F0008110 ! peptide hormone receptor binding [Term] id: CCO:F0008112 name: corticotropin-releasing hormone receptor 1 binding namespace: molecular_function def: "Interacting selectively with the protein corticotropin-releasing hormone receptor 1 (CRHR1). The CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on adrenocorticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857] synonym: "CRHR1 binding" EXACT [] xref: GO:0051430 is_a: CCO:F0008111 ! corticotropin-releasing hormone receptor binding [Term] id: CCO:F0008113 name: corticotropin-releasing hormone receptor 2 binding namespace: molecular_function def: "Interacting selectively with the protein corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery." [PMID:15134857] synonym: "CRHR2 binding" EXACT [] xref: GO:0051431 is_a: CCO:F0008111 ! corticotropin-releasing hormone receptor binding [Term] id: CCO:F0008114 name: BH1 domain binding namespace: molecular_function def: "Interacting selectively with the BH1 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01080] xref: GO:0051432 is_a: CCO:F0008096 ! BH domain binding [Term] id: CCO:F0008115 name: BH2 domain binding namespace: molecular_function def: "Interacting selectively with the BH2 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01258] xref: GO:0051433 is_a: CCO:F0008096 ! BH domain binding [Term] id: CCO:F0008116 name: BH3 domain binding namespace: molecular_function def: "Interacting selectively with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] xref: GO:0051434 is_a: CCO:F0008096 ! BH domain binding [Term] id: CCO:F0008117 name: BH4 domain binding namespace: molecular_function def: "Interacting selectively with the BH4 domain of a protein of the Bcl-2 family. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein." [InterPro:IPR003093, PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01260, Prosite:PS50063] xref: GO:0051435 is_a: CCO:F0008096 ! BH domain binding [Term] id: CCO:F0008118 name: gonadotropin-releasing hormone binding namespace: molecular_function def: "Interacting selectively with gonadotropin-releasing hormone, a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary and it is synthesized and released by the hypothalamus." [PMID:1984190] synonym: "gonadotrophin-releasing hormone binding" EXACT [] xref: GO:0051448 is_a: CCO:F0003529 ! peptide hormone binding [Term] id: CCO:F0008119 name: thyrotropin-releasing hormone binding namespace: molecular_function def: "Interacting selectively with thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system." [GOC:ai] xref: GO:0051449 is_a: CCO:F0003529 ! peptide hormone binding [Term] id: CCO:F0008120 name: ectoine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ectoine from one side of the membrane to the other. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai] subset: gosubset_prok xref: GO:0051471 is_a: CCO:F0001683 ! monocarboxylic acid transmembrane transporter activity [Term] id: CCO:F0008121 name: glucosylglycerol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a glucosylglycerol from one side of the membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: GO:0051474 is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity [Term] id: CCO:F0008122 name: mannosylglycerate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a mannosylglycerate from one side of the membrane to the other." [GOC:ai, PMID:15034926] xref: GO:0051477 is_a: CCO:F0002621 ! carbohydrate transmembrane transporter activity [Term] id: CCO:F0008123 name: syn-copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = syn-copalyl diphosphate." [MetaCyc:RXN-4861] synonym: "diterpene cyclase activity" BROAD [] xref: GO:0051498 xref: MetaCyc:RXN-4861 is_a: CCO:F0003432 ! intramolecular lyase activity [Term] id: CCO:F0008124 name: D-aminoacyl-tRNA deacylase activity namespace: molecular_function def: "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667] xref: GO:0051499 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0008125 name: D-tyrosyl-tRNA(Tyr) deacylase activity namespace: molecular_function def: "Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine resides in charged tRNA." [PMID:14527667] xref: GO:0051500 is_a: CCO:F0008124 ! D-aminoacyl-tRNA deacylase activity [Term] id: CCO:F0008126 name: cholesterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-cholesterol." [GOC:ai] xref: GO:0051505 is_a: CCO:F0003462 ! sterol 3-beta-glucosyltransferase activity [Term] id: CCO:F0008127 name: ergosterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-ergosterol." [GOC:ai] xref: GO:0051506 is_a: CCO:F0003462 ! sterol 3-beta-glucosyltransferase activity [Term] id: CCO:F0008128 name: beta-sitosterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-beta-sitosterol." [GOC:ai] xref: GO:0051507 is_a: CCO:F0003462 ! sterol 3-beta-glucosyltransferase activity [Term] id: CCO:F0008129 name: stigmasterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-stigmasterol." [GOC:ai] xref: GO:0051508 is_a: CCO:F0003462 ! sterol 3-beta-glucosyltransferase activity [Term] id: CCO:F0008130 name: tomatidine UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-tomatidine." [GOC:ai] xref: GO:0051509 is_a: CCO:F0003462 ! sterol 3-beta-glucosyltransferase activity [Term] id: CCO:F0008131 name: NFAT protein binding namespace: molecular_function def: "Interacting selectively with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system." [PMID:15928679] synonym: "NFAT binding" EXACT [] synonym: "nuclear factor of activated T cell protein binding" EXACT [] xref: GO:0051525 is_a: CCO:F0001738 ! transcription factor binding [Term] id: CCO:F0008132 name: NFAT1 protein binding namespace: molecular_function def: "Interacting selectively with NFAT1 (nuclear factor of activated T cells 1 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] synonym: "NFATc2 binding" EXACT [] synonym: "NFATp binding" EXACT [] xref: GO:0051526 is_a: CCO:F0008131 ! NFAT protein binding [Term] id: CCO:F0008133 name: NFAT2 protein binding namespace: molecular_function def: "Interacting selectively with NFAT2 (nuclear factor of activated T cells 2 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] synonym: "NFATc binding" EXACT [] synonym: "NFATc1 binding" EXACT [] xref: GO:0051527 is_a: CCO:F0008131 ! NFAT protein binding [Term] id: CCO:F0008134 name: NFAT3 protein binding namespace: molecular_function def: "Interacting selectively with NFAT3 (nuclear factor of activated T cells 3 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] synonym: "NFATc4 binding" EXACT [] xref: GO:0051528 is_a: CCO:F0008131 ! NFAT protein binding [Term] id: CCO:F0008135 name: NFAT4 protein binding namespace: molecular_function def: "Interacting selectively with NFAT4 (nuclear factor of activated T cells 4 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] synonym: "NFATc3 binding" RELATED [] synonym: "NFATx binding" EXACT [] xref: GO:0051529 is_a: CCO:F0008131 ! NFAT protein binding [Term] id: CCO:F0008136 name: NFAT5 protein binding namespace: molecular_function def: "Interacting selectively with NFAT1 (nuclear factor of activated T cells 1 protein), a member of the NFAT transcription factor family which is not calcium regulated." [GOC:ai] synonym: "non-calcium-regulated NFAT protein binding" EXACT [] xref: GO:0051530 is_a: CCO:F0008131 ! NFAT protein binding [Term] id: CCO:F0008137 name: syntaxin-5 binding namespace: molecular_function def: "Interacting selectively with the SNAP receptor syntaxin-5." [GOC:ai, PMID:12388752] xref: GO:0051535 is_a: CCO:F0004214 ! syntaxin binding [Term] id: CCO:F0008138 name: iron-sulfur cluster binding namespace: molecular_function def: "Interacting selectively with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] synonym: "Fe/S binding" EXACT [] synonym: "iron sulfur cluster binding" EXACT [] synonym: "iron sulphur cluster binding" EXACT [] synonym: "iron-sulphur cluster binding" EXACT [] xref: GO:0051536 is_a: CCO:F0008142 ! metal cluster binding [Term] id: CCO:F0008139 name: 2 iron, 2 sulfur cluster binding namespace: molecular_function def: "Interacting selectively with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, http://en.wikipedia.org/wiki/Iron-sulfur_cluster] synonym: "2 Fe 2 S cluster binding" EXACT [] synonym: "2 iron, 2 sulphur cluster binding" EXACT [] synonym: "2Fe-2S cluster binding" EXACT [] synonym: "diiron disulfide cluster binding" EXACT [] synonym: "diiron disulphide cluster binding" EXACT [] synonym: "iron-sulfur cluster 2Fe-2S binding" EXACT [] synonym: "iron-sulphur cluster 2Fe-2S binding" EXACT [] xref: GO:0051537 is_a: CCO:F0008138 ! iron-sulfur cluster binding [Term] id: CCO:F0008140 name: 3 iron, 4 sulfur cluster binding namespace: molecular_function def: "Interacting selectively with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing." [GOC:ai, http://en.wikipedia.org/wiki/Iron-sulfur_cluster] synonym: "3 Fe 4 S cluster binding" EXACT [] synonym: "3 iron, 4 sulphur cluster binding" EXACT [] synonym: "3Fe-4S cluster binding" EXACT [] synonym: "iron-sulfur cluster 3Fe-4S binding" EXACT [] synonym: "iron-sulphur cluster 3Fe-4S binding" EXACT [] synonym: "triiron tetrasulfide cluster binding" EXACT [] synonym: "triiron tetrasulphide cluster binding" EXACT [] xref: GO:0051538 is_a: CCO:F0008138 ! iron-sulfur cluster binding [Term] id: CCO:F0008141 name: 4 iron, 4 sulfur cluster binding namespace: molecular_function def: "Interacting selectively with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, http://en.wikipedia.org/wiki/Iron-sulfur_cluster] synonym: "4 Fe 4 S cluster binding" EXACT [] synonym: "4 iron, 4 sulphur cluster binding" EXACT [] synonym: "4Fe-4S cluster binding" EXACT [] synonym: "iron-sulfur cluster 4Fe-4S binding" EXACT [] synonym: "iron-sulphur cluster 4Fe-4S binding" EXACT [] synonym: "tetrairon tetrasulfide cluster binding" EXACT [] synonym: "tetrairon tetrasulphide cluster binding" EXACT [] xref: GO:0051539 is_a: CCO:F0008138 ! iron-sulfur cluster binding [Term] id: CCO:F0008142 name: metal cluster binding namespace: molecular_function def: "Interacting selectively with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg] subset: goslim_pir subset: gosubset_prok xref: GO:0051540 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0008143 name: anthocyanidin-3-glucoside rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP." [PMID:8130800] synonym: "3RT activity" BROAD [] synonym: "anthocyanidin 3-glucoside-rhamnosyltransferase activity" EXACT [] xref: GO:0051566 is_a: CCO:F0003333 ! transferase activity, transferring hexosyl groups [Term] id: CCO:F0008144 name: 5'-deoxyribose-5-phosphate lyase activity namespace: molecular_function def: "Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site." [PMID:11251121, PMID:16120966] synonym: "5'-deoxyribose phosphate activity" EXACT [] synonym: "dRP lyase activity" BROAD [] synonym: "dRPase activity" BROAD [] xref: GO:0051575 is_a: CCO:F0003401 ! carbon-oxygen lyase activity [Term] id: CCO:F0008145 name: Myf5 binding namespace: molecular_function def: "Interacting selectively with the muscle regulatory factor Myf5." [GOC:ai] xref: GO:0051576 is_a: CCO:F0005854 ! MRF binding [Term] id: CCO:F0008146 name: MyoD binding namespace: molecular_function def: "Interacting selectively with the muscle regulatory factor MyoD." [GOC:ai] xref: GO:0051577 is_a: CCO:F0005854 ! MRF binding [Term] id: CCO:F0008147 name: Mrf4 binding namespace: molecular_function def: "Interacting selectively with the muscle regulatory factor Mrf4." [GOC:ai] xref: GO:0051578 is_a: CCO:F0005854 ! MRF binding [Term] id: CCO:F0008148 name: myogenin binding namespace: molecular_function def: "Interacting selectively with the muscle regulatory factor myogenin." [GOC:ai] xref: GO:0051579 is_a: CCO:F0005854 ! MRF binding [Term] id: CCO:F0008149 name: bacterial cell surface binding namespace: molecular_function def: "Interacting selectively with any component on the surface of a bacterial cell." [GOC:ai] subset: gosubset_prok synonym: "bacterium cell surface binding" EXACT [] xref: GO:0051635 is_a: CCO:F0001847 ! bacterial binding is_a: CCO:F0005862 ! cell surface binding [Term] id: CCO:F0008150 name: Gram-negative bacterial cell surface binding namespace: molecular_function def: "Interacting selectively with any component on the surface of a Gram-negative bacterial cell." [GOC:ai] subset: gosubset_prok synonym: "Gram-negative bacterium cell surface binding" EXACT [] xref: GO:0051636 is_a: CCO:F0001848 ! Gram-negative bacterial binding is_a: CCO:F0008149 ! bacterial cell surface binding [Term] id: CCO:F0008151 name: Gram-positive bacterial cell surface binding namespace: molecular_function def: "Interacting selectively with any component on the surface of a Gram-positive bacterium." [GOC:ai] subset: gosubset_prok synonym: "Gram-positive bacterium cell surface binding" EXACT [] xref: GO:0051637 is_a: CCO:F0008054 ! Gram-positive bacterial binding is_a: CCO:F0008149 ! bacterial cell surface binding [Term] id: CCO:F0008152 name: fructan beta-fructosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.80] synonym: "beta-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.80] synonym: "exo-beta-D-fructosidase activity" EXACT [] synonym: "exo-beta-fructosidase activity" EXACT [] synonym: "fructan b-fructosidase activity" EXACT [] synonym: "fructan exohydrolase activity" EXACT [] synonym: "fructanase activity" EXACT [EC:3.2.1.80] synonym: "polysaccharide beta-fructofuranosidase activity" EXACT [] xref: EC:3.2.1.80 xref: GO:0051669 xref: MetaCyc:3.2.1.80-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0008153 name: inulinase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin." [EC:3.2.1.7] synonym: "2,1-beta-D-fructan fructanohydrolase activity" EXACT [] synonym: "endo-inulinase activity" EXACT [] synonym: "exoinulinase activity" EXACT [] synonym: "indoinulinase activity" EXACT [] synonym: "inulase activity" EXACT [] xref: EC:3.2.1.7 xref: GO:0051670 xref: MetaCyc:3.2.1.7-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0008154 name: isopullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)." [EC:3.2.1.57] synonym: "pullulan 4-glucanohydrolase (isopanose-forming) activity" EXACT [] xref: EC:3.2.1.57 xref: GO:0051675 xref: MetaCyc:3.2.1.57-RXN is_a: CCO:F0000939 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: CCO:F0008155 name: saccharopine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2." [PMID:16233628] synonym: "SAX activity" BROAD [] xref: GO:0051698 is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0008156 name: proline oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [MetaCyc:RXN-821] xref: EC:1.5.3.- xref: GO:0051699 xref: MetaCyc:RXN-821 is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0008157 name: fructosyl-amino acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2." [PMID:16233628] synonym: "FAOD activity" EXACT [] xref: EC:1.5.3.- xref: GO:0051700 is_a: CCO:F0003246 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: CCO:F0008158 name: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:bf, MetaCyc:3.1.3.62-RXN] synonym: "inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity" EXACT [EC:2.7.1.-] synonym: "inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity" EXACT [EC:2.7.1.-] synonym: "inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity" EXACT [EC:2.7.1.-] xref: GO:0051717 xref: MetaCyc:3.1.3.62-RXN is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity [Term] id: CCO:F0008159 name: DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpG." [EC:2.1.1.37, PMID:15689527] synonym: "HpaII methylase" NARROW [EC:2.1.1.37] synonym: "HpaII' methylase" NARROW [EC:2.1.1.37] synonym: "M.BsuRIa" NARROW [EC:2.1.1.37] synonym: "M.BsuRIb" NARROW [EC:2.1.1.37] xref: GO:0051718 is_a: CCO:F0000405 ! DNA (cytosine-5-)-methyltransferase activity [Term] id: CCO:F0008160 name: DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN." [EC:2.1.1.37, PMID:15689527] xref: GO:0051719 is_a: CCO:F0000405 ! DNA (cytosine-5-)-methyltransferase activity [Term] id: CCO:F0008161 name: DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG." [EC:2.1.1.37, PMID:15689527] xref: GO:0051720 is_a: CCO:F0000405 ! DNA (cytosine-5-)-methyltransferase activity [Term] id: CCO:F0008162 name: protein phosphatase 2A binding namespace: molecular_function def: "Interacting selectively with the enzyme protein phosphatase 2A." [GOC:ai] xref: GO:0051721 is_a: CCO:F0004212 ! protein phosphatase binding [Term] id: CCO:F0008163 name: protein C-terminal methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol." [PMID:10318862, PMID:8650216] synonym: "protein phosphatase methylesterase activity" NARROW [] xref: GO:0051722 is_a: CCO:F0008164 ! protein methylesterase activity [Term] id: CCO:F0008164 name: protein methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol." [GOC:ai] subset: gosubset_prok synonym: "PME activity" EXACT [EC:2.7.1.-] synonym: "protein carboxyl methylesterase activity" EXACT [EC:2.7.1.-] synonym: "protein carboxylic ester hydrolase activity" EXACT [] synonym: "protein methyl-esterase activity" EXACT [EC:2.7.1.-] xref: GO:0051723 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0008165 name: NAD transporter activity namespace: molecular_function def: "Enables the directed movement of nicotinamide adenine dinucleotide into, out of, within or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:ai] synonym: "NAD (oxidized) transporter activity" EXACT [] synonym: "NAD (reduced) transporter activity" EXACT [] synonym: "NAD+ transporter activity" EXACT [] synonym: "NADH transporter activity" EXACT [] synonym: "nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "oxidized NAD transporter activity" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "reduced NAD transporter activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] xref: GO:0051724 is_a: CCO:F0008066 ! cofactor transporter activity [Term] id: CCO:F0008166 name: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA." [EC:2.7.1.78, PMID:8428918] synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "GTP-dependent polyribonucleotide kinase activity" EXACT [] synonym: "GTP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "GTP-dependent RNA kinase activity" EXACT [] synonym: "GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] xref: GO:0051730 is_a: CCO:F0008168 ! polyribonucleotide kinase activity is_a: CCO:F0008171 ! GTP-dependent polynucleotide kinase activity [Term] id: CCO:F0008167 name: polynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] synonym: "5'-dephosphopolynucleotide kinase activity" EXACT [] synonym: "5'-hydroxyl polynucleotide kinase activity" EXACT [EC:2.7.1.78] synonym: "PNK" RELATED [EC:2.7.1.78] synonym: "polynucleotide 5'-hydroxy-kinase activity" EXACT [EC:2.7.1.78] synonym: "polynucleotide 5'-hydroxyl kinase (phosphorylating) activity" EXACT [EC:2.7.1.78] synonym: "polynucleotide 5'-hydroxyl-kinase activity" EXACT [EC:2.7.1.78] xref: EC:2.7.1.- xref: GO:0051731 is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor is_a: CCO:F0004128 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: CCO:F0008168 name: polyribonucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA." [EC:2.7.1.78] synonym: "5'-hydroxyl polyribonucleotide kinase activity" EXACT [EC:2.7.1.78] synonym: "5'-hydroxyl RNA kinase activity" EXACT [EC:2.7.1.78] synonym: "RNA 5'-hydroxyl kinase activity" EXACT [] synonym: "RNA kinase activity" EXACT [] xref: GO:0051732 is_a: CCO:F0008167 ! polynucleotide kinase activity [Term] id: CCO:F0008169 name: polydeoxyribonucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA." [EC:2.7.1.78] synonym: "DNA 5'-hydroxyl kinase activity" EXACT [] synonym: "DNA kinase activity" EXACT [] xref: GO:0051733 is_a: CCO:F0008167 ! polynucleotide kinase activity [Term] id: CCO:F0008170 name: ATP-dependent polynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphatase activity" EXACT [EC:2.7.1.78] synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] xref: EC:2.7.1.- xref: GO:0051734 is_a: CCO:F0008167 ! polynucleotide kinase activity [Term] id: CCO:F0008171 name: GTP-dependent polynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] synonym: "GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] xref: EC:2.7.1.- xref: GO:0051735 is_a: CCO:F0008167 ! polynucleotide kinase activity [Term] id: CCO:F0008172 name: ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA." [EC:2.7.1.78] synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "ATP-dependent polyribonucleotide kinase activity" EXACT [] synonym: "ATP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP-dependent RNA kinase activity" EXACT [] synonym: "ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] xref: GO:0051736 is_a: CCO:F0008168 ! polyribonucleotide kinase activity is_a: CCO:F0008170 ! ATP-dependent polynucleotide kinase activity [Term] id: CCO:F0008173 name: GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA." [EC:2.7.1.78, PMID:8428918] synonym: "GTP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "GTP-dependent DNA kinase activity" EXACT [] synonym: "GTP-dependent polydeoxyribonucleotide kinase activity" EXACT [] synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] xref: GO:0051737 is_a: CCO:F0008169 ! polydeoxyribonucleotide kinase activity is_a: CCO:F0008171 ! GTP-dependent polynucleotide kinase activity [Term] id: CCO:F0008174 name: xanthophyll binding namespace: molecular_function def: "Interacting selectively with xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen." [ISBN:0122146743] xref: GO:0051738 is_a: CCO:F0004189 ! isoprenoid binding is_a: CCO:F0004661 ! pigment binding [Term] id: CCO:F0008175 name: ammonia transporter activity namespace: molecular_function def: "Enables the directed movement of ammonia into, out of, within or between cells." [GOC:go_curators] subset: gosubset_prok xref: GO:0051739 is_a: CCO:F0004311 ! substrate-specific transporter activity [Term] id: CCO:F0008176 name: ethylene binding namespace: molecular_function def: "Interacting selectively with ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai] synonym: "ethene binding" EXACT [] xref: GO:0051740 is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0008177 name: 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542] synonym: "MPBQ methyltransferase activity" EXACT [] xref: GO:0051741 xref: MetaCyc:RXN-2542 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0008178 name: 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762] synonym: "MSBQ methyltransferase activity" EXACT [] xref: GO:0051742 xref: MetaCyc:RXN-2762 is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0008179 name: red chlorophyll catabolite reductase activity namespace: molecular_function def: "Catalysis of the reaction: red chlorophyll catabolite (RCC) + reduced ferredoxin + 2 H+ = primary fluorescent catabolite (pFCC) + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite to a colorless tetrapyrrole with a strong blue fluorescence." [PMID:10743659] synonym: "RCC reductase activity" EXACT [] xref: EC:1.3.7.- xref: GO:0051743 is_a: CCO:F0003237 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: CCO:F0008180 name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity namespace: molecular_function def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72] xref: GO:0051744 xref: MetaCyc:RXN1F-72 is_a: CCO:F0003172 ! oxidoreductase activity [Term] id: CCO:F0008181 name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.1.2] synonym: "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity" EXACT [EC:1.17.1.2] synonym: "isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity" EXACT [] xref: EC:1.17.1.2 xref: GO:0051745 xref: MetaCyc:1.17.1.2-RXN is_a: CCO:F0003308 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: CCO:F0008182 name: thalianol synthase activity namespace: molecular_function def: "Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)." [PMID:15125655] xref: GO:0051746 is_a: CCO:F0004686 ! oxidosqualene cyclase activity [Term] id: CCO:F0008183 name: DNA demethylase activity namespace: molecular_function def: "Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA." [PMID:10050851] xref: GO:0051747 is_a: CCO:F0003359 ! hydrolase activity is_a: CCO:F0004997 ! demethylase activity [Term] id: CCO:F0008184 name: UTP-monosaccharide-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166] subset: gosubset_prok synonym: "PsUSP" RELATED [EC:2.7.7.64] synonym: "UDP-monosaccharide diphosphorylase activity" EXACT [] synonym: "UDP-monosaccharide pyrophosphorylase activity" EXACT [] synonym: "UDP-sugar pyrophosphorylase activity" EXACT [EC:2.7.7.64] synonym: "USP" RELATED [EC:2.7.7.64] xref: EC:2.7.7.64 xref: GO:0051748 is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0008185 name: indole acetic acid carboxyl methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine." [PMID:16169896] synonym: "IAA carboxyl methyltransferase activity" EXACT [] xref: GO:0051749 is_a: CCO:F0001755 ! methyltransferase activity [Term] id: CCO:F0008186 name: delta3,5-delta2,4-dienoyl-CoA isomerase activity namespace: molecular_function def: "Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA." [PMID:16040662] xref: GO:0051750 is_a: CCO:F0003425 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: CCO:F0008187 name: alpha-1,4-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,4-linkage." [PMID:15772281] xref: GO:0051751 is_a: CCO:F0000008 ! mannosyltransferase activity [Term] id: CCO:F0008188 name: phosphoglucan, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate." [EC:2.7.9.5, PMID:15618411] synonym: "ATP:phospho-alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.5] synonym: "OK1" RELATED [EC:2.7.9.5] synonym: "PWD" RELATED [EC:2.7.9.5] xref: EC:2.7.9.5 xref: GO:0051752 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003353 ! phosphotransferase activity, paired acceptors [Term] id: CCO:F0008189 name: mannan synthase activity namespace: molecular_function def: "Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-1,4-linked mannan backbone in substrates such as galactomannan." [PMID:14726589] synonym: "galactomannan beta-1,4-mannosyltransferase activity" NARROW [] synonym: "mannan beta-1,4-mannosyltransferase activity" EXACT [] xref: GO:0051753 is_a: CCO:F0004117 ! beta-1,4-mannosyltransferase activity [Term] id: CCO:F0008190 name: inositol tetrakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai] xref: GO:0051765 is_a: CCO:F0000836 ! inositol or phosphatidylinositol kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0008191 name: inositol trisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP." [GOC:ai] xref: GO:0051766 is_a: CCO:F0000836 ! inositol or phosphatidylinositol kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0008192 name: ent-kaurenoate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-159] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. synonym: "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [EC:1.14.13.79] synonym: "ent-kaurenoic acid oxidase activity" EXACT [] xref: GO:0051777 xref: MetaCyc:RXN1F-159 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0008193 name: ent-7-alpha-hydroxykaurenoate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. xref: GO:0051778 xref: MetaCyc:RXN1F-160 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0008194 name: gibberellin 12-aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + O2 = gibberellin 12 (GA12) + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-161] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'. synonym: "GA12-aldehyde oxidase activity" EXACT [] xref: GO:0051779 xref: MetaCyc:RXN1F-161 is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0008195 name: all-trans-retinol 13,14-reductase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor. Note that this reaction has only been observed to occur in the opposite direction." [EC:1.3.99.23] synonym: "(13,14)-all-trans-retinol saturase activity" EXACT [] synonym: "all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity" EXACT [] synonym: "all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity" EXACT [] synonym: "retinol saturase activity" EXACT [EC:1.3.99.23] synonym: "RetSat activity" EXACT [EC:1.3.99.23] xref: EC:1.3.99.23 xref: GO:0051786 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0008196 name: misfolded protein binding namespace: molecular_function def: "Interacting selectively with a misfolded protein." [GOC:ai] xref: GO:0051787 is_a: CCO:F0001646 ! protein binding [Term] id: CCO:F0008197 name: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidyl inositol-4-phosphate + phosphate." [GOC:bf, PMID:9811831] synonym: "PTEN activity" BROAD [] xref: GO:0051800 is_a: CCO:F0000841 ! inositol or phosphatidylinositol phosphatase activity is_a: CCO:F0005684 ! lipid phosphatase activity [Term] id: CCO:F0008198 name: glycolipid binding namespace: molecular_function def: "Interacting selectively with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html] xref: GO:0051861 is_a: CCO:F0001816 ! lipid binding [Term] id: CCO:F0008199 name: histone demethylase activity (H3-K36 specific) namespace: molecular_function def: "Catalysis of the reaction: methyl-lysine + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. The methyl-lysine residue is at position 36 of histone 3." [PMID:16362057] synonym: "[histone-H3]-lysine-36 demethylase activity" EXACT [] synonym: "H3-K36-specific demethylase activity" EXACT [EC:1.14.11.27] synonym: "histone H3-lysine-36 demethylase activity" EXACT [EC:1.14.11.27] synonym: "histone-lysine (H3-K36) demethylase activity" EXACT [EC:1.14.11.27] synonym: "histone-lysine demethylase activity (H3-K36 specific)" EXACT [] synonym: "histone-lysine(H3-K36) demethylase activity" EXACT [] synonym: "JHDM1A activity" NARROW [EC:1.14.11.27] synonym: "JmjC domain-containing histone demethylase 1A activity" NARROW [EC:1.14.11.27] synonym: "protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27] synonym: "protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27] xref: EC:1.14.11.27 xref: GO:0051864 is_a: CCO:F0003289 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors is_a: CCO:F0004998 ! histone demethylase activity [Term] id: CCO:F0008200 name: methotrexate binding namespace: molecular_function def: "Interacting selectively with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln] subset: gosubset_prok xref: GO:0051870 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0008201 name: dihydrofolic acid binding namespace: molecular_function def: "Interacting selectively with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "DHF binding" RELATED [] synonym: "dihydrofolate binding" RELATED [] xref: GO:0051871 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0008202 name: Hsp90 protein binding namespace: molecular_function def: "Interacting selectively with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai] synonym: "Hsp90 binding" EXACT [] synonym: "Hsp90 class protein binding" EXACT [] xref: GO:0051879 is_a: CCO:F0004628 ! heat shock protein binding [Term] id: CCO:F0008203 name: G-quadruplex DNA binding namespace: molecular_function def: "Interacting selectively with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome." [PMID:16142245, PMID:9512530] synonym: "G-DNA binding" EXACT [] synonym: "G-quartet binding" EXACT [] synonym: "quadruplex DNA binding" EXACT [] synonym: "tetraplex DNA binding" EXACT [] xref: GO:0051880 is_a: CCO:F0005878 ! structure-specific DNA binding [Term] id: CCO:F0008204 name: S-(hydroxymethyl)glutathione dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284] synonym: "ADH3 activity" NARROW [EC:1.1.1.284] synonym: "chi-ADH activity" NARROW [EC:1.1.1.284] synonym: "class III alcohol dehydrogenase activity" RELATED [EC:1.1.1.284] synonym: "FDH activity" RELATED [EC:1.1.1.284] synonym: "formic dehydrogenase activity" RELATED [EC:1.1.1.284] synonym: "GD-FALDH activity" EXACT [EC:1.1.1.284] synonym: "glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "GS-FDH activity" EXACT [EC:1.1.1.284] synonym: "NAD- and glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "NAD-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "NAD-linked formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.284] xref: EC:1.1.1.284 xref: GO:0051903 xref: MetaCyc:RXN-2962 xref: UM-BBD_enzymeID:e0709 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008205 name: S-(hydroxymethyl)glutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione = glutathione + formaldehyde." [EC:4.4.1.22] synonym: "Gfa" RELATED [EC:4.4.1.22] synonym: "glutathione-dependent formaldehyde-activating enzyme activity" EXACT [] synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)" EXACT [EC:4.4.1.22] synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase activity" EXACT [EC:4.4.1.22] xref: EC:4.4.1.22 xref: GO:0051907 xref: MetaCyc:RXN-2961 is_a: CCO:F0003410 ! carbon-sulfur lyase activity [Term] id: CCO:F0008206 name: double-stranded DNA specific 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai] xref: GO:0051908 is_a: CCO:F0001823 ! double-stranded DNA specific exodeoxyribonuclease activity is_a: CCO:F0005595 ! 5'-3' exodeoxyribonuclease activity [Term] id: CCO:F0008207 name: acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O." [MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN] synonym: "3-hydroxypropenoate dehydratase activity" EXACT [] synonym: "acetylenecarboxylate hydratase activity" BROAD [] synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] synonym: "alkynoate hydratase activity" BROAD [] xref: EC:4.2.1.- xref: GO:0051909 xref: MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0008208 name: heparitin sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparitin = adenosine 3',5'-bisphosphate + N-sulfoheparitin." [MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN] synonym: "heparitin N-sulfotransferase activity" EXACT [] synonym: "heparitin N-sulphotransferase activity" EXACT [] xref: GO:0051910 xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0008209 name: Methanosarcina-phenazine hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine." [EC:1.12.98.3] synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] synonym: "hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity" EXACT [EC:1.12.98.3] synonym: "methanophenazine hydrogenase activity" EXACT [] synonym: "methylviologen-reducing hydrogenase activity" EXACT [] xref: EC:1.12.98.3 xref: GO:0051911 xref: MetaCyc:RXN-7733 is_a: CCO:F0006309 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors [Term] id: CCO:F0008210 name: CoB--CoM heterodisulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine." [EC:1.8.98.1] synonym: "CoB-CoM heterodisulfide reductase activity" EXACT [] synonym: "coenzyme B--coenzyme M heterodisulfide reductase activity" EXACT [] synonym: "coenzyme B:coenzyme M:methanophenazine oxidoreductase activity" EXACT [EC:1.8.98.1] synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] synonym: "heterodisulfide reductase activity" BROAD [] synonym: "soluble heterodisulfide reductase activity" RELATED [EC:1.8.98.1] xref: EC:1.8.98.1 xref: GO:0051912 xref: MetaCyc:1.8.98.1-RXN is_a: CCO:F0003260 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: CCO:F0008211 name: granulocyte colony-stimulating factor binding namespace: molecular_function def: "Interacting selectively with granulocyte colony-stimulating factor, G-CSF." [GOC:ai] synonym: "G-CSF binding" EXACT [] xref: GO:0051916 is_a: CCO:F0004221 ! cytokine binding [Term] id: CCO:F0008212 name: peroxiredoxin activity namespace: molecular_function def: "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15] subset: gosubset_prok synonym: "AhpC activity" NARROW [] synonym: "alkyl hydroperoxide reductase C22 activity" NARROW [] synonym: "PRDX activity" EXACT [] synonym: "Prx activity" EXACT [] synonym: "thiol-containing-reductant:hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.15] xref: EC:1.11.1.15 xref: GO:0051920 is_a: CCO:F0000981 ! peroxidase activity [Term] id: CCO:F0008213 name: adenosylcobyric acid synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate." [EC:6.3.5.10] synonym: "5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity" EXACT [] synonym: "adenosylcobyric acid synthase (glutamine-hydrolysing) activity" EXACT [] synonym: "adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.10] synonym: "Ado-cobyric acid synthase [glutamine hydrolyzing] activity" EXACT [] synonym: "CobQ activity" BROAD [] synonym: "cobyric acid synthase activity" RELATED [] xref: EC:6.3.5.10 xref: GO:0051921 xref: MetaCyc:R345-RXN is_a: CCO:F0003442 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: CCO:F0008214 name: cholesterol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate." [PMID:12730293] xref: EC:2.8.2.- xref: GO:0051922 is_a: CCO:F0000505 ! alcohol sulfotransferase activity [Term] id: CCO:F0008215 name: dynein light intermediate chain binding namespace: molecular_function def: "Interacting selectively with a light intermediate chain of the dynein complex." [GOC:bf] xref: GO:0051959 is_a: CCO:F0006133 ! dynein binding [Term] id: CCO:F0008216 name: lysophospholipid transporter activity namespace: molecular_function def: "Enables the directed movement of lysophospholipids into, out of, within or between cells. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai] subset: gosubset_prok xref: GO:0051978 is_a: CCO:F0001671 ! phospholipid transporter activity [Term] id: CCO:F0008217 name: iron-nicotianamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other." [GOC:ai] synonym: "Fe-NA chelate transporter activity" EXACT [] xref: GO:0051980 is_a: CCO:F0002966 ! iron chelate transmembrane transporter activity [Term] id: CCO:F0008218 name: copper chelate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com] subset: gosubset_prok xref: GO:0051981 is_a: CCO:F0001598 ! copper ion transmembrane transporter activity [Term] id: CCO:F0008219 name: copper-nicotianamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other." [GOC:ai] synonym: "Cu-NA chelate transporter activity" EXACT [] xref: GO:0051982 is_a: CCO:F0008218 ! copper chelate transmembrane transporter activity [Term] id: CCO:F0008220 name: coproporphyrinogen dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine." [EC:1.3.99.22] synonym: "coproporphyrinogen III oxidase activity" EXACT [EC:1.3.99.22] synonym: "coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.22] synonym: "HemN" RELATED [EC:1.3.99.22] synonym: "oxygen-independent coproporphyrinogen-III oxidase activity" EXACT [] synonym: "radical SAM enzyme activity" RELATED [EC:1.3.99.22] xref: EC:1.3.99.22 xref: GO:0051989 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0008222 name: cyclopentanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopentanol + NAD+ = cyclopentanone + NADH + H+." [EC:1.1.1.163, GOC:jic, GOC:mlg] synonym: "cyclopentanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.163] synonym: "cyclopentanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.163] xref: EC:1.1.1.163 xref: GO:0055041 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008223 name: 5-valerolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate." [GOC:jic, GOC:mlg] xref: GO:0055042 is_a: CCO:F0006225 ! lactonohydrolase activity [Term] id: CCO:F0008224 name: 5-oxovalerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+." [GOC:jic, GOC:mlg] xref: GO:0055043 is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008225 name: mannose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+." [GOC:ct] xref: GO:0055053 is_a: CCO:F0002404 ! hexose:hydrogen symporter activity is_a: CCO:F0002958 ! mannose transmembrane transporter activity [Term] id: CCO:F0008226 name: fructose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+." [GOC:ct] xref: GO:0055054 is_a: CCO:F0001579 ! fructose transmembrane transporter activity is_a: CCO:F0002404 ! hexose:hydrogen symporter activity [Term] id: CCO:F0008227 name: D-glucose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory isomer of glucose." [GOC:ct] xref: GO:0055055 is_a: CCO:F0001582 ! hydrogen:glucose symporter activity is_a: CCO:F0008228 ! D-glucose transmembrane transporter activity [Term] id: CCO:F0008228 name: D-glucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of the dextrorotatory isomer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:jic] xref: GO:0055056 is_a: CCO:F0001581 ! glucose transmembrane transporter activity [Term] id: CCO:F0008229 name: gap junction hemi-channel activity namespace: molecular_function def: "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction." [GOC:dgh] synonym: "connexon channel activity" EXACT [] xref: GO:0055077 is_a: CCO:F0004262 ! wide pore channel activity relationship: part_of CCO:F0001511 ! gap junction channel activity [Term] id: CCO:F0008230 name: adiponectin binding namespace: molecular_function def: "Interacting selectively with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism." [GOC:rl, PMID:15210937] xref: GO:0055100 is_a: CCO:F0005682 ! hormone binding [Term] id: CCO:F0008231 name: glycerophospholipase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a glycerophospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai, GOC:rl] xref: GO:0055101 is_a: CCO:F0001215 ! phospholipase inhibitor activity [Term] id: CCO:F0008232 name: lipase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:rl] xref: GO:0055102 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0008233 name: ligase regulator activity namespace: molecular_function def: "Modulates the activity of a ligase." [GOC:rl] xref: GO:0055103 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0008234 name: ligase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ligase." [GOC:rl] xref: GO:0055104 is_a: CCO:F0001213 ! enzyme inhibitor activity [Term] id: CCO:F0008235 name: ubiquitin-protein ligase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ubiquitin-protein ligase." [GOC:rl] xref: GO:0055105 is_a: CCO:F0008234 ! ligase inhibitor activity is_a: CCO:F0008236 ! ubiquitin-protein ligase regulator activity [Term] id: CCO:F0008236 name: ubiquitin-protein ligase regulator activity namespace: molecular_function def: "Modulates the activity of a ubiquitin-protein ligase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:rl] xref: GO:0055106 is_a: CCO:F0008233 ! ligase regulator activity [Term] id: CCO:F0008237 name: minus-end directed microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557] synonym: "minus-end directed actin filament motor activity" RELATED [GOC:dph] synonym: "minus-end directed actin-filament motor activity" EXACT [GOC:dph] synonym: "pointed-end directed actin-filament motor activity" EXACT [GOC:dph] xref: GO:0060001 is_a: CCO:F0000026 ! microfilament motor activity [Term] id: CCO:F0008238 name: plus-end directed microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers." [GOC:dph, PMID:10519557] synonym: "barbed-end directed actin-filament motor activity" EXACT [GOC:dph] synonym: "plus-end directed actin filament motor activity" RELATED [GOC:dph] synonym: "plus-end directed actin-filament motor activity" EXACT [GOC:dph] xref: GO:0060002 is_a: CCO:F0000026 ! microfilament motor activity [Term] id: CCO:F0008239 name: large conductance calcium-activated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074] synonym: "BK calcium-activated potassium channel activity" EXACT [] synonym: "BK channel activity" RELATED [] synonym: "BK KCa channels" EXACT [] synonym: "large conductance KCa channels" EXACT [] xref: GO:0022895 xref: GO:0060072 is_a: CCO:F0002726 ! calcium-activated potassium channel activity [Term] id: CCO:F0008240 name: molecular transducer activity namespace: molecular_function def: "The molecular function that accepts an input of one form and creates an output of a different form." [GOC:mtg_MIT] subset: goslim_pir subset: gosubset_prok xref: GO:0060089 is_a: CCO:F0000272 ! molecular_function [Term] id: CCO:F0008241 name: molecular adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together two or more molecules, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT] subset: goslim_pir subset: gosubset_prok xref: GO:0060090 is_a: CCO:F0001633 ! binding [Term] id: CCO:F0008242 name: brain-derived neurotrophic factor receptor activity namespace: molecular_function def: "Combining with brain-derived neurotrophic factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph] synonym: "BDNF receptor activity" RELATED [GOC:dph] xref: GO:0060175 is_a: CCO:F0001080 ! transmembrane receptor protein tyrosine kinase activity is_a: CCO:F0001357 ! neurotrophin receptor activity [Term] id: CCO:F0008243 name: apelin receptor activity namespace: molecular_function def: "Combining with the peptide apelin to initiate a change in cell activity." [GOC:dph] xref: GO:0060182 is_a: CCO:F0001980 ! peptide receptor activity, G-protein coupled [Term] id: CCO:F0008244 name: phosphatidylcholine-sterol O-acyltransferase activator activity namespace: molecular_function def: "Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines." [GOC:dph, GOC:tb, PMID:4335615] synonym: "LCAT activator activity" NARROW [GOC:tb] xref: GO:0060228 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0008245 name: lipase activator activity namespace: molecular_function def: "Increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:dph, GOC:tb] xref: GO:0060229 is_a: CCO:F0001691 ! enzyme activator activity [Term] id: CCO:F0008246 name: lipoprotein lipase activator activity namespace: molecular_function def: "Increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein." [GOC:dph, GOC:tb, PMID:10727238] xref: GO:0060230 is_a: CCO:F0008245 ! lipase activator activity [Term] id: CCO:F0008247 name: [cytochrome c]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59] synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59] xref: EC:2.1.1.59 xref: GO:0000277 xref: MetaCyc:2.1.1.59-RXN is_a: CCO:F0003100 ! protein-lysine N-methyltransferase activity [Term] id: CCO:F0008248 name: (R,R)-butanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+." [EC:1.1.1.4] subset: gosubset_prok synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4] xref: EC:1.1.1.4 xref: GO:0000721 xref: MetaCyc:(R is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008249 name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92] synonym: "asialo-GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GalNAc-T activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "GM2/GD2-synthase activity" EXACT [EC:2.4.1.92] synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] xref: EC:2.4.1.92 xref: GO:0003947 xref: MetaCyc:2.4.1.92-RXN is_a: CCO:F0001852 ! acetylgalactosaminyltransferase activity [Term] id: CCO:F0008250 name: (S)-2-hydroxy-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + H2O2." [EC:1.1.3.15] subset: gosubset_prok synonym: "(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] synonym: "hydroxyacid oxidase A" RELATED [EC:1.1.3.15] synonym: "L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15] xref: EC:1.1.3.15 xref: GO:0003973 xref: MetaCyc:(S)-2-HYDROXY-ACID-OXIDASE-RXN is_a: CCO:F0003457 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: CCO:F0008251 name: [acyl-carrier-protein] S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38] synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT [] synonym: "ACAT activity" EXACT [EC:2.3.1.38] synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" EXACT [EC:2.3.1.38] synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP S-acetyltransferase activity" EXACT [] synonym: "ACPacetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38] xref: EC:2.3.1.38 xref: GO:0004313 xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN xref: Reactome:76142 is_a: CCO:F0000733 ! fatty-acid synthase activity is_a: CCO:F0003141 ! S-acetyltransferase activity [Term] id: CCO:F0008252 name: [acyl-carrier-protein] S-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39] subset: gosubset_prok synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT [] synonym: "ACP S-malonyltransferase activity" EXACT [] synonym: "acyl carrier protein malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl carrier proteinmalonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "FabD" RELATED [EC:2.3.1.39] synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39] synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39] synonym: "malonyl-CoA-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:ACP transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:AcpM transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "MAT" RELATED [EC:2.3.1.39] synonym: "MCAT activity" EXACT [EC:2.3.1.39] xref: EC:2.3.1.39 xref: GO:0004314 xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN xref: Reactome:10341 is_a: CCO:F0000733 ! fatty-acid synthase activity is_a: CCO:F0003142 ! S-malonyltransferase activity [Term] id: CCO:F0008253 name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43] synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT [] synonym: "phosphopyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT [] synonym: "pyruvate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] xref: EC:3.1.3.43 xref: GO:0004741 xref: GO:0019906 xref: MetaCyc:3.1.3.43-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0008254 name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.-, GOC:ai] synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT [] xref: EC:4.2.1.- xref: GO:0008659 is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0008255 name: (2,3-dihydroxybenzoyl)adenylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate = diphosphate + (2,3-dihydroxybenzoyl)adenylate." [EC:2.7.7.58, MetaCyc:2.7.7.58-RXN] subset: gosubset_prok synonym: "2,3-dihydroxybenzoate-AMP ligase activity" EXACT [] synonym: "ATP:2,3-dihydroxybenzoate adenylyltransferase activity" EXACT [EC:2.7.7.58] xref: EC:2.7.7.58 xref: GO:0008668 xref: MetaCyc:DHBAMPLIG-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0008256 name: [acyl-carrier-protein] phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14] subset: gosubset_prok synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT [] synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "ACP hydrolyase activity" EXACT [EC:3.1.4.14] synonym: "ACP phosphodiesterase activity" EXACT [] synonym: "AcpH" RELATED [EC:3.1.4.14] synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14] synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] xref: EC:3.1.4.14 xref: GO:0008770 xref: MetaCyc:3.1.4.14-RXN is_a: CCO:F0001701 ! phosphoric diester hydrolase activity [Term] id: CCO:F0008257 name: [citrate (pro-3S)-lyase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22] subset: gosubset_prok synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" EXACT [EC:6.2.1.22] synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22] synonym: "acetate:HS-citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate (pro-3S)-lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22] xref: EC:6.2.1.22 xref: GO:0008771 xref: MetaCyc:CITC-RXN is_a: CCO:F0003437 ! acid-thiol ligase activity [Term] id: CCO:F0008258 name: [isocitrate dehydrogenase (NADP+)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5] subset: gosubset_prok synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" EXACT [EC:2.7.11.5] synonym: "ICDH kinase/phosphatase activity" EXACT [EC:2.7.11.5] synonym: "IDH kinase activity" EXACT [EC:2.7.11.5] synonym: "IDH kinase/phosphatase activity" EXACT [EC:2.7.11.5] synonym: "IDH-K/P" RELATED [EC:2.7.11.5] synonym: "IDHK/P" RELATED [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP+) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase/phosphatase activity" EXACT [EC:2.7.11.5] synonym: "STK3" RELATED [EC:2.7.11.5] xref: EC:2.7.11.5 xref: GO:0008772 xref: MetaCyc:PHOSICITDEHASE-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0008259 name: [protein-PII] uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59] subset: gosubset_prok synonym: "PII uridylyl-transferase activity" EXACT [EC:2.7.7.59] synonym: "protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59] synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT [] synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] xref: EC:2.7.7.59 xref: GO:0008773 xref: MetaCyc:URITRANS-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0008260 name: [glutamate-ammonia-ligase] adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (L-glutamate:ammonia ligase (ADP-forming)) = diphosphate + adenylyl-(L-glutamate:ammonia ligase (ADP-forming))." [EC:2.7.7.42] subset: gosubset_prok synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT [] synonym: "ATP:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT [] synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] xref: EC:2.7.7.42 xref: GO:0008882 xref: MetaCyc:GSADENYLATION-RXN is_a: CCO:F0003351 ! nucleotidyltransferase activity [Term] id: CCO:F0008261 name: (+)-abscisic acid 8'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-abscisate + NADPH + H+ + O2 = 8'-hydroxyabscisate + NADP+ + H2O." [EC:1.14.13.93] synonym: "(+)-ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] synonym: "ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED [] synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" EXACT [EC:1.14.13.93] synonym: "abscisic acid 8'-hydroxylase activity" EXACT [] xref: EC:1.14.13.93 xref: GO:0010295 xref: MetaCyc:1.14.13.93-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0008262 name: [heparan sulfate]-glucosamine N-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-desulfoheparin = adenosine 3',5'-bisphosphate + heparin." [EC:2.8.2.8] comment: Note that this activity includes EC:2.8.2.12 (deleted from EC). synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT [] synonym: "desulfoheparin sulfotransferase activity" EXACT [] synonym: "glucosaminyl N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate 2-N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparin N-deacetylase/N-sulfotransferase activity" RELATED [] synonym: "heparin N-deacetylase/N-sulphotransferase activity" RELATED [] synonym: "heparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "N-heparan sulfate sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "N-HSST activity" EXACT [EC:2.8.2.8] synonym: "PAPS:DSH sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "PAPS:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] xref: EC:2.8.2.8 xref: GO:0004393 xref: GO:0015016 xref: GO:0015022 xref: MetaCyc:DESULFOHEPARIN-SULFOTRANSFERASE-RXN is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0008263 name: [cytochrome c]-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [EC:2.1.1.124, GOC:ma] synonym: "cytochrome c-arginine N-methyltransferase activity" EXACT [EC:2.1.1.124] synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea" RELATED [EC:2.1.1.124] synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124] xref: EC:2.1.1.124 xref: GO:0016275 xref: MetaCyc:2.1.1.124-RXN is_a: CCO:F0003096 ! protein-arginine N-methyltransferase activity [Term] id: CCO:F0008264 name: [myelin basic protein]-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [EC:2.1.1.126] synonym: "myelin basic protein methylase activity" EXACT [EC:2.1.1.126] synonym: "myelin basic protein methylase I" RELATED [EC:2.1.1.126] synonym: "myelin basic protein-arginine N-methyltransferase activity" EXACT [EC:2.1.1.126] synonym: "protein methylase I activity" BROAD [EC:2.1.1.126] synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.126] synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.126] xref: EC:2.1.1.126 xref: GO:0016277 xref: MetaCyc:2.1.1.126-RXN is_a: CCO:F0003096 ! protein-arginine N-methyltransferase activity [Term] id: CCO:F0008265 name: (R)-6-hydroxynicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2." [EC:1.5.3.6] subset: gosubset_prok synonym: "(R)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.6] synonym: "6-hydroxy-D-nicotine oxidase activity" EXACT [] synonym: "D-6-hydroxynicotine oxidase activity" EXACT [EC:1.5.3.6] xref: EC:1.5.3.6 xref: GO:0018530 xref: MetaCyc:(R)-6-HYDROXYNICOTINE-OXIDASE-RXN xref: UM-BBD_enzymeID:e0338 is_a: CCO:F0004062 ! hydroxy-nicotine oxidase activity [Term] id: CCO:F0008266 name: (S)-6-hydroxynicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2." [EC:1.5.3.5] subset: gosubset_prok synonym: "(S)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] synonym: "6-hydroxy-L-nicotine oxidase activity" EXACT [] synonym: "6-hydroxy-L-nicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] synonym: "L-6-hydroxynicotine oxidase activity" EXACT [] xref: EC:1.5.3.5 xref: GO:0018531 xref: MetaCyc:(S)-6-HYDROXYNICOTINE-OXIDASE-RXN xref: UM-BBD_enzymeID:e0339 is_a: CCO:F0004062 ! hydroxy-nicotine oxidase activity [Term] id: CCO:F0008267 name: (S)-limonene 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-isopiperitenol + NADP+ + H2O." [EC:1.14.13.47] synonym: "(-)-limonene 3-hydroxylase activity" EXACT [EC:1.14.13.47] synonym: "(-)-limonene 3-monooxygenase activity" EXACT [] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.13.47] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.47] synonym: "limonene 3-hydroxylase activity" EXACT [] xref: EC:1.14.13.47 xref: GO:0018674 xref: MetaCyc:(-)-LIMONENE-3-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0467 is_a: CCO:F0004059 ! limonene monooxygenase activity [Term] id: CCO:F0008268 name: (S)-limonene 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O." [EC:1.14.13.48] synonym: "(-)-limonene 6-hydroxylase activity" EXACT [EC:1.14.13.48] synonym: "(-)-limonene 6-monooxygenase activity" EXACT [] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.48] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.48] synonym: "limonene 6-hydroxylase activity" EXACT [] xref: EC:1.14.13.48 xref: GO:0018675 xref: MetaCyc:(-)-LIMONENE-6-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0445 is_a: CCO:F0004059 ! limonene monooxygenase activity [Term] id: CCO:F0008269 name: (S)-limonene 7-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-perillyl alcohol + NADP+ + H2O." [EC:1.14.13.49] synonym: "(-)-limonene 7-monooxygenase activity" EXACT [] synonym: "(-)-limonene hydroxylase activity" EXACT [EC:1.14.13.49] synonym: "(-)-limonene monooxygenase activity" EXACT [EC:1.14.13.49] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating) activity" EXACT [EC:1.14.13.49] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.13.49] synonym: "limonene hydroxylase activity" EXACT [] xref: EC:1.14.13.49 xref: GO:0018676 xref: MetaCyc:(-)-LIMONENE-7-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0458 is_a: CCO:F0004059 ! limonene monooxygenase activity [Term] id: CCO:F0008270 name: (3,5-dichlorophenylurea)acetate amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [UM-BBD_enzymeID:e0440] xref: EC:3.5.1.- xref: GO:0018749 xref: UM-BBD_enzymeID:e0440 is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0008271 name: (S)-2-haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.2] subset: gosubset_prok synonym: "(S)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-haloacid dehalogenase activity" EXACT [] synonym: "2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-haloalkanoic acid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "2-haloalkanoid acid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-halocarboxylic acid dehalogenase II activity" EXACT [EC:3.8.1.2] synonym: "DL-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "halocarboxylic acid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "L-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "L-DEX activity" EXACT [EC:3.8.1.2] xref: EC:3.8.1.2 xref: GO:0018784 xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN xref: UM-BBD_enzymeID:e0021 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0008272 name: (hydroxyamino)benzene mutase activity namespace: molecular_function def: "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_enzymeID:e0246] synonym: "(hydroxyamino)benzene hydroxymutase activity" EXACT [EC:5.4.4.1] synonym: "HAB mutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene hydroxymutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene mutase activity" EXACT [EC:5.4.4.1] xref: GO:0018824 xref: UM-BBD_enzymeID:e0246 is_a: CCO:F0007827 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: CCO:F0008273 name: (R)-aminopropanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH + H+." [EC:1.1.1.75] synonym: "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "1-aminopropan-2-ol-dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "1-aminopropan-2-ol-NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "L-aminopropanol dehydrogenase activity" EXACT [] xref: EC:1.1.1.75 xref: GO:0019147 xref: MetaCyc:AMINOPROPDEHYDROG-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008274 name: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity namespace: molecular_function def: "Modification of the activity of the enzyme [pyruvate dehydrogenase (lipoamide)] phosphatase." [EC:3.1.3.43, GOC:ai] synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity" NARROW [] xref: GO:0019909 is_a: CCO:F0004205 ! protein phosphatase regulator activity [Term] id: CCO:F0008275 name: [methionine synthase] reductase activity namespace: molecular_function def: "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8] comment: Note that this was EC:2.1.1.135. synonym: "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED [] synonym: "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT [] synonym: "methionine synthase cob(II)alamin reductase (methylating) activity" EXACT [EC:1.16.1.8] synonym: "methionine synthase reductase activity" EXACT [EC:1.16.1.8] synonym: "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" EXACT [EC:1.16.1.8] synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.8] xref: EC:1.16.1.8 xref: GO:0030586 xref: MetaCyc:2.1.1.135-RXN is_a: CCO:F0002378 ! electron carrier activity is_a: CCO:F0003305 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: CCO:F0008276 name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115] synonym: "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "(rs)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "norreticuline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] xref: EC:2.1.1.115 xref: GO:0030776 xref: MetaCyc:2.1.1.115-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0008277 name: (S)-scoulerine 9-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine." [EC:2.1.1.117] synonym: "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] synonym: "S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] xref: EC:2.1.1.117 xref: GO:0030777 xref: MetaCyc:2.1.1.117-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0008278 name: (S)-tetrahydroprotoberberine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122] synonym: "S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] synonym: "tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] xref: EC:2.1.1.122 xref: GO:0030782 xref: MetaCyc:2.1.1.122-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0008279 name: [cytochrome c]-methionine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123] synonym: "cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] synonym: "S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] xref: EC:2.1.1.123 xref: GO:0030783 xref: MetaCyc:2.1.1.123-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0008280 name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127] synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "RuBisCO LSMT activity" EXACT [EC:2.1.1.127] synonym: "rubisco methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "RuBisCO methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.127] xref: EC:2.1.1.127 xref: GO:0030785 xref: MetaCyc:2.1.1.127-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0008281 name: (RS)-norcoclaurine 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128] synonym: "S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity" EXACT [EC:2.1.1.128] xref: EC:2.1.1.128 xref: GO:0030786 xref: MetaCyc:2.1.1.128-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0008282 name: (S)-coclaurine-N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140] synonym: "S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity" EXACT [EC:2.1.1.140] xref: EC:2.1.1.140 xref: GO:0030794 xref: MetaCyc:2.1.1.140-RXN is_a: CCO:F0002103 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: CCO:F0008283 name: (+)-trans-carveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-trans-carveol + NAD+ = (+)-(S)-carvone + NADH + H+." [EC:1.1.1.275] synonym: "(+)-trans-carveol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.275] xref: EC:1.1.1.275 xref: GO:0033702 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008284 name: (S)-mandelate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor." [EC:1.1.99.31] synonym: "(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.31] synonym: "L(+)-mandelate dehydrogenase activity" EXACT [EC:1.1.99.31] synonym: "MDH" RELATED [EC:1.1.99.31] xref: EC:1.1.99.31 xref: GO:0033720 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0008285 name: (R)-benzylsuccinyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein." [EC:1.3.99.21] synonym: "(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.21] synonym: "(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.21] synonym: "BbsG" RELATED [EC:1.3.99.21] xref: EC:1.3.99.21 xref: GO:0033734 is_a: CCO:F0003228 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: CCO:F0008286 name: [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "3-OST-2" RELATED [EC:2.8.2.29] synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29] synonym: "glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29] xref: EC:2.8.2.29 xref: GO:0033871 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0008287 name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate." [EC:2.8.2.30] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30] synonym: "3-OST-3" RELATED [EC:2.8.2.30] synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30] synonym: "glucosaminyl 3-O-sulfotransferase 3a, 3b activity" EXACT [EC:2.8.2.30] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity" EXACT [EC:2.8.2.30] synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30] xref: EC:2.8.2.30 xref: GO:0033872 is_a: CCO:F0001748 ! sulfotransferase activity [Term] id: CCO:F0008288 name: (R)-2-haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.9] synonym: "(R)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.9] synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.9] synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.9] synonym: "D-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.9] synonym: "D-DEX" RELATED [EC:3.8.1.9] xref: EC:3.8.1.9 xref: GO:0033975 is_a: CCO:F0004066 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: CCO:F0008289 name: (R)-limonene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (+)-(4R)-limonene + diphosphate." [EC:4.2.3.20] synonym: "(+)-limonene synthase activity" EXACT [EC:4.2.3.20] synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity" EXACT [EC:4.2.3.20] synonym: "geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity" EXACT [EC:4.2.3.20] xref: EC:4.2.3.20 xref: GO:0034002 is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0008290 name: (carboxyethyl)arginine beta-lactam-synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-N2-(2-carboxyethyl)arginine = AMP + diphosphate + deoxyamidinoproclavaminate." [EC:6.3.3.4] synonym: "beta-lactam synthetase activity" EXACT [EC:6.3.3.4] synonym: "L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4] synonym: "L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4] xref: EC:6.3.3.4 xref: GO:0034027 is_a: CCO:F0003441 ! cyclo-ligase activity [Term] id: CCO:F0008291 name: [formate-C-acetyltransferase]-activating enzyme activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical." [EC:1.97.1.4, GOC:jl] synonym: "[pyruvate formate-lyase]-activating enzyme activity" EXACT [EC:1.97.1.4] synonym: "formate acetyltransferase activating enzyme activity" EXACT [EC:1.97.1.4] synonym: "formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity" EXACT [EC:1.97.1.4] synonym: "formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)" EXACT [EC:1.97.1.4] synonym: "formate-C-acetyltransferase-activating enzyme" RELATED [EC:1.97.1.4] synonym: "PFL activase activity" EXACT [EC:1.97.1.4] synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity" EXACT [EC:1.97.1.4] synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4] xref: EC:1.97.1.4 xref: GO:0008862 xref: GO:0043365 xref: MetaCyc:TDCEACT-RXN is_a: CCO:F0003172 ! oxidoreductase activity is_a: CCO:F0005842 ! catalysis of free radical formation [Term] id: CCO:F0008292 name: (R)-2-hydroxyisocaproate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+." [GOC:jl, PMID:16957230] subset: gosubset_prok xref: EC:1.1.1.- xref: GO:0043713 is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008293 name: (R)-citramalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA." [GOC:jl, PMID:9864346] subset: gosubset_prok synonym: "citramalate synthase" BROAD [] xref: EC:2.3.3.- xref: GO:0043714 is_a: CCO:F0006267 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: CCO:F0008294 name: (S)-lactate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP." [IMG:00356, PMID:11535063] subset: gosubset_prok synonym: "lactate 2-kinase activity" EXACT [] xref: EC:2.7.1.- xref: GO:0043841 xref: MetaCyc:RXN-8076 is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:F0008295 name: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity namespace: molecular_function def: "Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate." [PMID:15356000, PMID:16494480] comment: This function is involved in archaeal lipid synthesis. subset: gosubset_prok synonym: "2,3-dGGGPS" EXACT [] synonym: "DGGGP synthase activity" EXACT [] synonym: "DGGGPS" EXACT [] synonym: "UbiA" RELATED [] xref: EC:2.5.1.- xref: GO:0043888 is_a: CCO:F0000268 ! polyprenyltransferase activity is_a: CCO:F0000756 ! geranyltranstransferase activity [Term] id: CCO:F0008296 name: (S)-3-O-geranylgeranylglyceryl phosphate activity namespace: molecular_function def: "Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate." [PMID:12801917, PMID:17253090, PMID:8408023] comment: This function is involved in archaeal lipid synthesis. subset: gosubset_prok synonym: "(S)-3-O-geranylgeranylglycerylphosphate activity" EXACT [] synonym: "(S)-GGGP synthase activity" EXACT [] synonym: "GGGP synthase activity" EXACT [] synonym: "GGGPS" EXACT [] xref: GO:0043889 is_a: CCO:F0001032 ! prenyltransferase activity [Term] id: CCO:F0008297 name: (S)-usnate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-usnic acid + NADH + H+ = NAD+ + 2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methyl-phenyl)-3-hydroxy-6-methyl-cyclohexa-2,4-dienone." [EC:1.1.1.199, MetaCyc:1.1.1.199-RXN] synonym: "L-usnic acid dehydrogenase activity" EXACT [EC:1.1.1.199] synonym: "reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)" EXACT [EC:1.1.1.199] xref: EC:1.1.1.199 xref: GO:0046998 xref: MetaCyc:1.1.1.199-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008298 name: (R)-4-hydroxyphenyllactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + (R)-3-(4-hydroxyphenyl)lactate = NAD(P)H + H+ + 3-(4-hydroxyphenyl)pyruvate." [EC:1.1.1.222, MetaCyc:1.1.1.222-RXN] synonym: "(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.222] synonym: "(R)-aromatic lactate dehydrogenase activity" EXACT [EC:1.1.1.222] synonym: "D-hydrogenase, D-aryllactate" EXACT [EC:1.1.1.222] xref: EC:1.1.1.222 xref: GO:0047029 xref: MetaCyc:1.1.1.222-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008299 name: (S)-carnitine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + L-carnitine = NADH + H+ + 3-dehydrocarnitine." [EC:1.1.1.254, MetaCyc:1.1.1.254-RXN] synonym: "(S)-carnitine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.254] synonym: "D-carnitine dehydrogenase activity" EXACT [EC:1.1.1.254] xref: EC:1.1.1.254 xref: GO:0047041 xref: MetaCyc:1.1.1.254-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008300 name: (R)-2-hydroxy-fatty-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + R-2-hydroxystearate = NADH + H+ + 2-oxostearate." [EC:1.1.1.98, MetaCyc:1.1.1.98-RXN] synonym: "(R)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.98] synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.98] synonym: "D-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.98] xref: EC:1.1.1.98 xref: GO:0047049 xref: MetaCyc:1.1.1.98-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008301 name: (S)-2-hydroxy-fatty-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (S)-2-hydroxystearate = NADH + H+ + 2-oxostearate." [EC:1.1.1.99, MetaCyc:1.1.1.99-RXN] synonym: "(S)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.99] synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.99] synonym: "dehydrogenase, L-2-hydroxy fatty acid" EXACT [EC:1.1.1.99] synonym: "L-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.99] xref: EC:1.1.1.99 xref: GO:0047050 xref: MetaCyc:1.1.1.99-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008302 name: (S)-stylopine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + S-cheilanthifoline = 2 H2O + NADP+ + S-stylopine." [EC:1.14.21.1, MetaCyc:1.1.3.32-RXN] synonym: "(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.1] synonym: "(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.1] xref: EC:1.14.21.1 xref: GO:0047052 xref: MetaCyc:1.1.3.32-RXN is_a: CCO:F0006310 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: CCO:F0008303 name: (S)-cheilanthifoline synthase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + S-scoulerine = 2 H2O + NADP+ + S-cheilanthifoline." [EC:1.14.21.2, MetaCyc:1.14.21.2-RXN] synonym: "(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity" EXACT [] synonym: "(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.2] xref: EC:1.14.21.2 xref: GO:0047053 xref: MetaCyc:1.14.21.2-RXN is_a: CCO:F0006310 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: CCO:F0008304 name: (S)-canadine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + S-tetrahydrocolumbamine = 2 H2O + NADP+ + S-canadine." [EC:1.14.21.5, MetaCyc:1.1.3.36-RXN] synonym: "(S)-tetrahydroberberine synthase activity" EXACT [EC:1.14.21.5] synonym: "(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.5] synonym: "(S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.5] xref: EC:1.14.21.5 xref: GO:0047056 xref: MetaCyc:1.1.3.36-RXN is_a: CCO:F0006310 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: CCO:F0008305 name: (R)-pantolactone dehydrogenase (flavin) activity namespace: molecular_function def: "Catalysis of the reaction: acceptor + pantoyl lactone = reduced acceptor + 2-dehydropantoyl lactone." [EC:1.1.99.27, MetaCyc:1.1.99.27-RXN] synonym: "(R)-pantolactone:acceptor oxidoreductase (flavin-containing)" EXACT [EC:1.1.99.27] synonym: "(R)-pantoyllactone dehydrogenase (flavin) activity" EXACT [EC:1.1.99.27] synonym: "2-dehydropantolactone reductase (flavin) activity" EXACT [EC:1.1.99.27] synonym: "2-dehydropantoyl-lactone reductase (flavin) activity" EXACT [EC:1.1.99.27] xref: EC:1.1.99.27 xref: GO:0047060 xref: MetaCyc:1.1.99.27-RXN is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0008306 name: (R)-3-hydroxyacid-ester dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + ethyl (R)-3-hydroxyhexanoate = NADPH + ethyl-3-oxohexanoate." [EC:1.1.1.279, MetaCyc:1.2.1.55-RXN] comment: Note that this term was EC:1.2.1.55. synonym: "(R)-3-hydroxyacid ester dehydrogenase activity" EXACT [] synonym: "3-oxo ester (R)-reductase activity" EXACT [EC:1.1.1.279] synonym: "ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.279] xref: EC:1.1.1.279 xref: GO:0047108 xref: MetaCyc:1.2.1.55-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008307 name: (S)-3-hydroxyacid-ester dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + ethyl (S)-3-hydroxyhexanoate = NADPH + ethyl-3-oxohexanoate." [EC:1.1.1.280, MetaCyc:1.2.1.56-RXN] comment: Note that this term was EC:1.2.1.56. synonym: "(S)-3-hydroxyacid ester dehydrogenase activity" EXACT [] synonym: "3-oxo ester (S)-reductase activity" EXACT [EC:1.1.1.280] synonym: "ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.280] xref: EC:1.1.1.280 xref: GO:0047109 xref: MetaCyc:1.2.1.56-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008308 name: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate = NADH + CO2 + protocatechuate." [EC:1.3.1.53, MetaCyc:1.3.1.53-RXN] synonym: "(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53] synonym: "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.53] synonym: "dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53] xref: EC:1.3.1.53 xref: GO:0047120 xref: MetaCyc:1.3.1.53-RXN is_a: CCO:F0003229 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008309 name: (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(alpha-N-acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R + CMP." [EC:2.4.99.7, MetaCyc:2.4.99.7-RXN] synonym: "(alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity" EXACT [] synonym: "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.7] synonym: "cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "neuac-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "sialyltransferase 3C activity" RELATED [EC:2.4.99.7] synonym: "sialyltransferase 7D activity" RELATED [EC:2.4.99.7] synonym: "SIAT7" RELATED [EC:2.4.99.7] synonym: "ST6GALNAC activity" EXACT [EC:2.4.99.7] xref: EC:2.4.99.7 xref: GO:0047290 xref: MetaCyc:2.4.99.7-RXN is_a: CCO:F0001849 ! sialyltransferase activity [Term] id: CCO:F0008310 name: (S)-3-amino-2-methylpropionate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + (S)-3-amino-2-methylpropanoate = L-glutamate + methylmalonate-semialdehyde." [EC:2.6.1.22, MetaCyc:2.6.1.22-RXN] subset: gosubset_prok synonym: "(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.22] synonym: "(S)-3-amino-2-methylpropionate aminotransferase activity" EXACT [] synonym: "beta-aminobutyric transaminase activity" EXACT [EC:2.6.1.22] synonym: "beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.22] synonym: "L-3-aminoisobutyrate aminotransferase activity" EXACT [EC:2.6.1.22] synonym: "L-3-aminoisobutyrate transaminase activity" EXACT [EC:2.6.1.22] synonym: "L-3-aminoisobutyric aminotransferase activity" EXACT [EC:2.6.1.22] synonym: "L-AIBAT activity" EXACT [EC:2.6.1.22] xref: EC:2.6.1.22 xref: GO:0047298 xref: MetaCyc:2.6.1.22-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0008311 name: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + (R)-3-amino-2-methylpropanoate = L-alanine + methylmalonate-semialdehyde." [EC:2.6.1.40, MetaCyc:2.6.1.40-RXN] comment: Note that this function was EC:2.6.1.61. synonym: "(R)-3-amino-2-methylpropanoate aminotransferase activity" EXACT [] synonym: "(R)-3-amino-2-methylpropanoate transaminase activity" EXACT [] synonym: "(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "(R)-3-amino-2-methylpropionate transaminase activity" EXACT [] synonym: "(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity" EXACT [] synonym: "beta-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40] synonym: "beta-aminoisobutyrate-pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "D-3-aminoisobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "D-3-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40] synonym: "D-3-aminoisobutyrate-pyruvate transaminase activity" EXACT [EC:2.6.1.40] synonym: "D-AIBAT activity" EXACT [EC:2.6.1.40] synonym: "D-beta-aminoisobutyrate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] xref: EC:2.6.1.40 xref: GO:0047305 xref: GO:0047314 xref: MetaCyc:2.6.1.40-RXN is_a: CCO:F0001944 ! transaminase activity [Term] id: CCO:F0008312 name: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP." [EC:2.7.11.31, MetaCyc:2.7.1.109-RXN] synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "3-hydroxy-3-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "AMPK" RELATED [EC:2.7.11.31] synonym: "ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity" EXACT [EC:2.7.11.31] synonym: "beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "HMG-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "reductase kinase activity" BROAD [EC:2.7.11.31] synonym: "STK29" RELATED [EC:2.7.11.31] xref: EC:2.7.11.31 xref: GO:0047322 xref: MetaCyc:2.7.1.109-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0008313 name: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.4] synonym: "3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity" EXACT [EC:2.7.11.4] synonym: "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity" EXACT [] synonym: "ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.4] synonym: "BCK" RELATED [EC:2.7.11.4] synonym: "BCKD kinase activity" EXACT [EC:2.7.11.4] synonym: "BCODH kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain 2-oxo acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain alpha-ketoacid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain keto acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.4] synonym: "STK2" RELATED [EC:2.7.11.4] xref: EC:2.7.11.4 xref: GO:0047323 xref: MetaCyc:2.7.11.4-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0008314 name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]." [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity" EXACT [EC:3.1.3.47] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.47] synonym: "reductase phosphatase activity" BROAD [EC:3.1.3.47] xref: EC:3.1.3.47 xref: GO:0047384 xref: MetaCyc:3.1.3.47-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0008315 name: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]." [EC:3.1.3.52, MetaCyc:3.1.3.52-RXN] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.52] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.52] synonym: "branched-chain 2-keto acid dehydrogenase phosphatase activity" EXACT [EC:3.1.3.52] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" BROAD [EC:3.1.3.52] synonym: "branched-chain oxo-acid dehydrogenase phosphatase activity" RELATED [EC:3.1.3.52] xref: EC:3.1.3.52 xref: GO:0047385 xref: MetaCyc:3.1.3.52-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0008316 name: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = cyclohexanone + acetyl-CoA." [EC:4.1.3.35, MetaCyc:4.1.3.35-RXN] synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.35] synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity" EXACT [EC:4.1.3.35] xref: EC:4.1.3.35 xref: GO:0047446 xref: MetaCyc:4.1.3.35-RXN is_a: CCO:F0003400 ! oxo-acid-lyase activity [Term] id: CCO:F0008317 name: (+)-delta-cadinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = pyrophosphate + (+)-delta-cadinene." [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)" EXACT [EC:4.2.3.13] synonym: "D-cadinene synthase activity" EXACT [EC:4.2.3.13] xref: EC:4.2.3.13 xref: GO:0047461 xref: MetaCyc:4.6.1.11-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0008318 name: (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(1,4-alpha-D-glucosyl)(n-1)-D-glucose = 1-alpha-D-(1,4-alpha-D-glucosyl)(n-1)-alpha-D-glucopyranoside." [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN] subset: gosubset_prok synonym: "(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase" BROAD [EC:5.4.99.15] synonym: "malto-oligosyltrehalose synthase activity" EXACT [EC:5.4.99.15] synonym: "maltodextrin alpha-D-glucosyltransferase activity" EXACT [EC:5.4.99.15] xref: EC:5.4.99.15 xref: GO:0047470 xref: MetaCyc:5.4.99.15-RXN is_a: CCO:F0003427 ! intramolecular transferase activity [Term] id: CCO:F0008319 name: (+)-borneol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-borneol + NAD+ = (+)-camphor + NADH + H+." [EC:1.1.1.198, MetaCyc:(+)-BORNEOL-DEHYDROGENASE-RXN] synonym: "(+)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.198] synonym: "bicyclic monoterpenol dehydrogenase activity" EXACT [EC:1.1.1.198] xref: EC:1.1.1.198 xref: GO:0047500 xref: MetaCyc:(+)-BORNEOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008320 name: (+)-neomenthol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-neomenthol + NADP+ = (-)-menthone + NADPH + H+." [EC:1.1.1.208, MetaCyc:(+)-NEOMENTHOL-DEHYDROGENASE-RXN] synonym: "(+)-neomenthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.208] synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.208] xref: EC:1.1.1.208 xref: GO:0047501 xref: MetaCyc:(+)-NEOMENTHOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008321 name: (+)-sabinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (+)-sabinone + NADH + H+." [EC:1.1.1.228, MetaCyc:(+)-SABINOL-DEHYDROGENASE-RXN] synonym: "(+)-cis-sabinol dehydrogenase activity" EXACT [EC:1.1.1.228] synonym: "(+)-cis-sabinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.228] xref: EC:1.1.1.228 xref: GO:0047502 xref: MetaCyc:(+)-SABINOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008322 name: (-)-borneol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-borneol + NAD+ = (-)-camphor + NADH + H+." [EC:1.1.1.227, MetaCyc:(-)-BORNEOL-DEHYDROGENASE-RXN] synonym: "(-)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.227] xref: EC:1.1.1.227 xref: GO:0047503 xref: MetaCyc:(-)-BORNEOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008323 name: (-)-menthol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthol + NADP+ = (-)-menthone + NADPH + H+." [EC:1.1.1.207, MetaCyc:(-)-MENTHOL-DEHYDROGENASE-RXN] synonym: "(-)-menthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.207] synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.207] xref: EC:1.1.1.207 xref: GO:0047504 xref: MetaCyc:(-)-MENTHOL-DEHYDROGENASE-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008324 name: (-)-menthol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthol + NADPH + H+ + O2 = p-menthane-3,8-diol + NADP+ + H2O." [EC:1.14.13.46, MetaCyc:(-)-MENTHOL-MONOOXYGENASE-RXN] synonym: "(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.46] synonym: "l-menthol monooxygenase activity" EXACT [EC:1.14.13.46] xref: EC:1.14.13.46 xref: GO:0047505 xref: MetaCyc:(-)-MENTHOL-MONOOXYGENASE-RXN is_a: CCO:F0003292 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: CCO:F0008325 name: (deoxy)adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dAMP = ADP + dADP." [EC:2.7.4.11, MetaCyc:(DEOXY)ADENYLATE-KINASE-RXN] synonym: "ATP:(d)AMP phosphotransferase activity" EXACT [EC:2.7.4.11] xref: EC:2.7.4.11 xref: GO:0047506 xref: MetaCyc:(DEOXY)ADENYLATE-KINASE-RXN is_a: CCO:F0003114 ! kinase activity is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor [Term] id: CCO:F0008326 name: (deoxy)nucleoside-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate." [EC:2.7.4.13, MetaCyc:(DEOXY)NUCLEOSIDE-PHOSPHATE-KINASE-RXN] synonym: "ATP:deoxynucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.13] synonym: "deoxynucleoside monophosphate kinase activity" EXACT [EC:2.7.4.13] synonym: "deoxynucleoside-5'-monophosphate kinase activity" EXACT [EC:2.7.4.13] synonym: "deoxyribonucleoside monophosphokinase activity" EXACT [EC:2.7.4.13] xref: EC:2.7.4.13 xref: GO:0047507 xref: MetaCyc:(DEOXY)NUCLEOSIDE-PHOSPHATE-KINASE-RXN is_a: CCO:F0003348 ! phosphotransferase activity, phosphate group as acceptor is_a: CCO:F0004128 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: CCO:F0008327 name: (R)-2-methylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-methylmalate = 2-methylmaleate + H2O." [EC:4.2.1.35, MetaCyc:(R)-2-METHYLMALATE-DEHYDRATASE-RXN] synonym: "(-)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.35] synonym: "(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)" EXACT [EC:4.2.1.35] synonym: "(R)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.35] synonym: "citraconase activity" EXACT [EC:4.2.1.35] synonym: "citraconate hydratase activity" EXACT [EC:4.2.1.35] synonym: "citramalate hydro-lyase activity" EXACT [EC:4.2.1.35] xref: EC:4.2.1.35 xref: GO:0047508 xref: MetaCyc:(R)-2-METHYLMALATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0008328 name: (R)-dehydropantoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-4-dehydropantoate + NAD+ + H2O = (R)-3,3-dimethylmalate + NADH + H+." [EC:1.2.1.33, MetaCyc:(R)-DEHYDROPANTOATE-DEHYDROGENASE-RXN] synonym: "(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.2.1.33] synonym: "D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity" EXACT [EC:1.2.1.33] synonym: "D-aldopantoate dehydrogenase activity" EXACT [EC:1.2.1.33] xref: EC:1.2.1.33 xref: GO:0047509 xref: MetaCyc:(R)-DEHYDROPANTOATE-DEHYDROGENASE-RXN is_a: CCO:F0003222 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008329 name: (S)-2-methylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-methylmalate = 2-methylfumarate + H2O." [EC:4.2.1.34, MetaCyc:(S)-2-METHYLMALATE-DEHYDRATASE-RXN] synonym: "(+)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.34] synonym: "(+)-citramalic hydro-lyase activity" EXACT [EC:4.2.1.34] synonym: "(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)" EXACT [EC:4.2.1.34] synonym: "(S)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.34] synonym: "citramalate dehydratase activity" EXACT [EC:4.2.1.34] synonym: "L-citramalate hydrolase activity" EXACT [EC:4.2.1.34] synonym: "mesaconase activity" EXACT [EC:4.2.1.34] synonym: "mesaconate hydratase activity" EXACT [EC:4.2.1.34] synonym: "mesaconate mesaconase activity" EXACT [EC:4.2.1.34] xref: EC:4.2.1.34 xref: GO:0047510 xref: MetaCyc:(S)-2-METHYLMALATE-DEHYDRATASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0008330 name: (S)-methylmalonyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = methylmalonate + CoA." [EC:3.1.2.17, MetaCyc:(S)-METHYLMALONYL-COA-HYDROLASE-RXN] synonym: "D-methylmalonyl-coenzyme A hydrolase activity" EXACT [EC:3.1.2.17] xref: EC:3.1.2.17 xref: GO:0047511 xref: MetaCyc:(S)-METHYLMALONYL-COA-HYDROLASE-RXN is_a: CCO:F0003105 ! CoA hydrolase activity [Term] id: CCO:F0008331 name: (S,S)-butanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + NADH + H+." [EC:1.1.1.76, MetaCyc:(S] synonym: "(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.76] synonym: "L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)" EXACT [EC:1.1.1.76] synonym: "L-BDH" RELATED [EC:1.1.1.76] synonym: "L-butanediol dehydrogenase activity" EXACT [EC:1.1.1.76] xref: EC:1.1.1.76 xref: GO:0047512 xref: MetaCyc:(S is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008332 name: [citrate-(pro-3S)-lyase] thiolesterase activity namespace: molecular_function def: "Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate." [EC:3.1.2.16, MetaCyc:CITRATE-(PRO-3S)-LYASE-THIOLESTERASE-RXN] synonym: "[citrate-(pro-3S)-lyase] thioesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate (pro-3S)-lyase thiolesterase activity" EXACT [] synonym: "citrate lyase deacetylase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase thioesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase thiolesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" EXACT [EC:3.1.2.16] xref: EC:3.1.2.16 xref: GO:0047778 xref: MetaCyc:CITRATE-(PRO-3S)-LYASE-THIOLESTERASE-RXN is_a: CCO:F0003361 ! thiolester hydrolase activity [Term] id: CCO:F0008333 name: [phosphorylase] phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate." [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN] synonym: "glycogen phosphorylase phosphatase activity" EXACT [EC:3.1.3.17] synonym: "phosphorylase a phosphatase activity" EXACT [EC:3.1.3.17] synonym: "phosphorylase a phosphohydrolase activity" EXACT [EC:3.1.3.17] synonym: "phosphorylase phosphatase activity" EXACT [] synonym: "PR-enzyme" RELATED [EC:3.1.3.17] synonym: "protein phosphatase C" RELATED [EC:3.1.3.17] synonym: "type 1 protein phosphatase activity" EXACT [EC:3.1.3.17] xref: EC:3.1.3.17 xref: GO:0050196 xref: MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0008334 name: [tyrosine 3-monooxygenase] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]." [EC:2.7.11.6, MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN] synonym: "ATP:tyrosine-3-monoxygenase phosphotransferase activity" EXACT [EC:2.7.11.6] synonym: "pheochromocytoma tyrosine hydroxylase-associated kinase activity" EXACT [EC:2.7.11.6] synonym: "STK4" RELATED [EC:2.7.11.6] synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.6] synonym: "tyrosine 3-monooxygenase kinase activity" EXACT [] xref: EC:2.7.11.6 xref: GO:0050369 xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0008335 name: [acetyl-CoA carboxylase] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate." [EC:2.7.11.27, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN] synonym: "acetyl coenzyme A carboxylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase bound kinase activity" NARROW [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase (AMP-activated) activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase (cAMP-independent) activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase 2 activity" NARROW [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase-2 activity" NARROW [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase-3 (AMP-activated) activity" NARROW [EC:2.7.11.27] synonym: "acetyl-coenzyme A carboxylase kinase activity" EXACT [EC:2.7.11.27] synonym: "ACK2" RELATED [EC:2.7.11.27] synonym: "ACK3" RELATED [EC:2.7.11.27] synonym: "AMPK" RELATED [EC:2.7.11.27] synonym: "ATP:acetyl-CoA carboxylase phosphotransferase activity" EXACT [EC:2.7.11.27] synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27] synonym: "STK5" RELATED [EC:2.7.11.27] xref: EC:2.7.11.27 xref: GO:0050405 xref: MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0008336 name: [acetyl-CoA carboxylase]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate." [EC:3.1.3.44, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-PHOSPHATASE-RXN] synonym: "acetyl-CoA carboxylase-phosphatase activity" EXACT [EC:3.1.3.44] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.44] xref: EC:3.1.3.44 xref: GO:0050406 xref: MetaCyc:[ACETYL-COA-CARBOXYLASE\]-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0008337 name: [glycogen-synthase-D] phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate." [EC:3.1.3.42, MetaCyc:[GLYCOGEN-SYNTHASE-D\]-PHOSPHATASE-RXN] synonym: "glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen synthase D phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen synthetase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen-synthase-D phosphatase activity" EXACT [EC:3.1.3.42] synonym: "Mg2+ dependent glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "phosphatase type 2oC" RELATED [EC:3.1.3.42] synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42] synonym: "UDP-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "UDPglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42] synonym: "uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] xref: EC:3.1.3.42 xref: GO:0050407 xref: MetaCyc:[GLYCOGEN-SYNTHASE-D\]-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0008338 name: [pyruvate kinase]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate." [EC:3.1.3.49, MetaCyc:[PYRUVATE-KINASE\]-PHOSPHATASE-RXN] synonym: "ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.49] synonym: "pyruvate kinase phosphatase activity" EXACT [EC:3.1.3.49] synonym: "pyruvate kinase-phosphatase activity" EXACT [EC:3.1.3.49] xref: EC:3.1.3.49 xref: GO:0050408 xref: MetaCyc:[PYRUVATE-KINASE\]-PHOSPHATASE-RXN is_a: CCO:F0003362 ! phosphoric monoester hydrolase activity [Term] id: CCO:F0008339 name: (-)-endo-fenchol synthase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + geranyl-PP = pyrophosphate + (-)-endo-fenchol." [EC:4.2.3.10, MetaCyc:4.2.3.10-RXN] synonym: "(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10] synonym: "geranyl pyrophosphate:(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10] synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]" RELATED [EC:4.2.3.10] xref: EC:4.2.3.10 xref: GO:0050437 xref: MetaCyc:4.2.3.10-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0008340 name: (S)-norcoclaurine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O." [EC:4.2.1.78] synonym: "(S)-norlaudanosoline synthase activity" EXACT [EC:4.2.1.78] synonym: "4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)" EXACT [EC:4.2.1.78] synonym: "4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]" RELATED [EC:4.2.1.78] xref: EC:4.2.1.78 xref: GO:0050474 xref: GO:0050475 xref: MetaCyc:(S)-NORLAUDANOSOLINE-SYNTHASE-RXN is_a: CCO:F0003402 ! hydro-lyase activity [Term] id: CCO:F0008341 name: (S)-N-acetyl-1-phenylethylamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylphenylethylamine + H2O = phenylethylamine + acetate." [EC:3.5.1.85, MetaCyc:3.5.1.85-RXN] synonym: "(S)-N-acetyl-1-phenylethylamine amidohydrolase activity" EXACT [EC:3.5.1.85] synonym: "(S)-N-acetylphenylethylamine:H2O hydrolase activity" EXACT [EC:3.5.1.85] xref: EC:3.5.1.85 xref: GO:0050536 xref: MetaCyc:3.5.1.85-RXN is_a: CCO:F0003380 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: CCO:F0008342 name: (4S)-limonene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = limonene + diphosphate." [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN] synonym: "(-)-(4S)-limonene synthase activity" EXACT [] synonym: "4S-(-)-limonene synthase activity" EXACT [EC:4.2.3.16] synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]" RELATED [EC:4.2.3.16] synonym: "geranyldiphosphate diphosphate lyase (limonene forming)" EXACT [EC:4.2.3.16] synonym: "geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]" RELATED [EC:4.2.3.16] xref: EC:4.2.3.16 xref: GO:0050552 xref: MetaCyc:4.2.3.16-RXN is_a: CCO:F0003404 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: CCO:F0008343 name: (R)-2-hydroxyacid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+." [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN] subset: gosubset_prok synonym: "(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "(R)-sulfolactate:NAD(P)(+) oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "L-sulfolactate dehydrogenase activity" EXACT [EC:1.1.1.272] xref: EC:1.1.1.272 xref: GO:0050578 xref: MetaCyc:1.1.1.272-RXN is_a: CCO:F0003218 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: CCO:F0008344 name: (iso)eugenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol." [EC:2.1.1.146, MetaCyc:2.1.1.146-RXN] synonym: "isoeugenol O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity" EXACT [EC:2.1.1.146] xref: EC:2.1.1.146 xref: GO:0050630 xref: MetaCyc:2.1.1.146-RXN is_a: CCO:F0001758 ! O-methyltransferase activity [Term] id: CCO:F0008345 name: (R)-2-hydroxyglutarate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT [] xref: EC:1.1.1.- xref: GO:0051990 is_a: CCO:F0003216 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: CCO:F0008346 name: type I interferon receptor activity namespace: molecular_function def: "Combining with a type I interferon to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon-alpha receptor activity" NARROW [] synonym: "interferon-alpha/beta receptor activity" NARROW [] synonym: "interferon-beta receptor activity" NARROW [] synonym: "interferon-delta receptor activity" NARROW [] synonym: "interferon-epsilon receptor activity" NARROW [] synonym: "interferon-kappa receptor activity" NARROW [] synonym: "interferon-omega receptor activity" NARROW [] synonym: "interferon-tau receptor activity" NARROW [] synonym: "interferon-zeta receptor activity" NARROW [] xref: GO:0004905 is_a: CCO:F0001251 ! interferon receptor activity is_a: CCO:F0008347 ! type I interferon binding [Term] id: CCO:F0008347 name: type I interferon binding namespace: molecular_function def: "Interacting selectively with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon-alpha binding" NARROW [] synonym: "interferon-alpha/beta binding" NARROW [] synonym: "interferon-beta binding" NARROW [] synonym: "interferon-delta binding" NARROW [] synonym: "interferon-epsilon binding" NARROW [] synonym: "interferon-kappa binding" NARROW [] synonym: "interferon-omega binding" NARROW [] synonym: "interferon-tau binding" NARROW [] synonym: "interferon-zeta binding" NARROW [] xref: GO:0019962 is_a: CCO:F0004227 ! interferon binding [Term] id: CCO:F0008348 name: nicotinic acid riboside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinic acid riboside (NaR) = ADP + nicotinic acid mononucleotide (NaMN)." [PMID:17914902] xref: GO:0034317 is_a: CCO:F0004129 ! nucleoside kinase activity [Term] id: CCO:F0008349 name: alcohol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule." [GOC:mah] synonym: "acyl-CoA:alcohol O-acyltransferase activity" EXACT [] synonym: "acyl-CoA:ethanol O-acyltransferase" NARROW [] synonym: "acyl-coenzymeA:alcohol O-acyltransferase activity" EXACT [] synonym: "acyl-coenzymeA:ethanol O-acyltransferase activity" NARROW [] synonym: "AEATase activity" NARROW [] synonym: "alcohol acyltransferase activity" EXACT [] xref: GO:0034318 is_a: CCO:F0001850 ! O-acyltransferase activity [Term] id: CCO:F0008350 name: alcohol O-butanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester." [GOC:mah, PMID:16361250] xref: GO:0034319 is_a: CCO:F0003136 ! O-acetyltransferase activity is_a: CCO:F0008349 ! alcohol O-acyltransferase activity is_a: CCO:F0008354 ! O-butanoyltransferase activity [Term] id: CCO:F0008351 name: alcohol O-hexanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester." [GOC:mah, PMID:16361250] xref: GO:0034320 is_a: CCO:F0003136 ! O-acetyltransferase activity is_a: CCO:F0008349 ! alcohol O-acyltransferase activity is_a: CCO:F0008355 ! O-hexanoyltransferase activity [Term] id: CCO:F0008352 name: alcohol O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester." [GOC:mah, PMID:16361250] xref: GO:0034321 is_a: CCO:F0003136 ! O-acetyltransferase activity is_a: CCO:F0003137 ! O-octanoyltransferase activity is_a: CCO:F0008349 ! alcohol O-acyltransferase activity [Term] id: CCO:F0008353 name: alcohol O-decanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester." [GOC:mah, PMID:16361250] xref: GO:0034322 is_a: CCO:F0003136 ! O-acetyltransferase activity is_a: CCO:F0008349 ! alcohol O-acyltransferase activity is_a: CCO:F0008356 ! O-decanoyltransferase activity [Term] id: CCO:F0008354 name: O-butanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule." [GOC:mah] xref: GO:0034323 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0008357 ! butanoyltransferase activity [Term] id: CCO:F0008355 name: O-hexanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule." [GOC:mah] xref: GO:0034324 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0008358 ! hexanoyltransferase activity [Term] id: CCO:F0008356 name: O-decanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule." [GOC:mah] xref: GO:0034325 is_a: CCO:F0001850 ! O-acyltransferase activity is_a: CCO:F0008359 ! decanoyltransferase activity [Term] id: CCO:F0008357 name: butanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule." [GOC:mah] xref: GO:0034326 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0008358 name: hexanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule." [GOC:mah] xref: GO:0034327 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0008359 name: decanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule." [GOC:mah] xref: GO:0034328 is_a: CCO:F0001882 ! acyltransferase activity [Term] id: CCO:F0008361 name: misfolded RNA binding namespace: molecular_function def: "Interacting selectively with an RNA molecule that has assumed an incorrect conformation." [GOC:mah, PMID:10393192] synonym: "RNA chaperone" RELATED [] xref: GO:0034336 is_a: CCO:F0000308 ! RNA binding [Term] id: CCO:F0008362 name: short-chain carboxylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp] synonym: "butyrate esterase activity" NARROW [] synonym: "butyryl esterase activity" NARROW [] synonym: "methylbutyrase activity" NARROW [] synonym: "methylbutyrate esterase activity" NARROW [] synonym: "monobutyrase activity" NARROW [] synonym: "propionyl esterase activity" NARROW [] synonym: "short-chain esterase activity" BROAD [] xref: GO:0034338 is_a: CCO:F0000566 ! carboxylesterase activity [Term] id: CCO:F0008363 name: type III interferon binding namespace: molecular_function def: "Interacting selectively with a type III interferon. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "interferon-lambda binding" EXACT [] xref: GO:0034347 is_a: CCO:F0004227 ! interferon binding [Term] id: CCO:F0008364 name: type III interferon receptor activity namespace: molecular_function def: "Combining with a type III interferon to initiate a change in cell activity. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "interferon-lambda receptor activity" EXACT [] xref: GO:0034348 is_a: CCO:F0001251 ! interferon receptor activity is_a: CCO:F0008363 ! type III interferon binding [Term] id: CCO:F0008365 name: RNA pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end." [GOC:jh2, PMID:17612492, PMID:18202662] xref: GO:0034353 is_a: CCO:F0003166 ! pyrophosphatase activity [Term] id: CCO:F0008366 name: FAT10 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein FAT10 to other proteins." [GOC:mah, PMID:12826404] synonym: "FAT10 conjugating enzyme activity" RELATED [] xref: GO:0019775 is_a: CCO:F0004170 ! small conjugating protein ligase activity [Term] id: CCO:F0008367 name: APG8 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein APG8 to substrate molecules; phosphatidylethanolamine is a known substrate." [GOC:mah, PMID:12826404] synonym: "APG8 conjugating enzyme activity" EXACT [] xref: GO:0019776 is_a: CCO:F0003438 ! ligase activity, forming carbon-nitrogen bonds [Term] id: CCO:F0008368 name: APG12 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein APG12 to other proteins." [GOC:mah, PMID:12826404] synonym: "APG12 conjugating enzyme activity" EXACT [] xref: GO:0019777 is_a: CCO:F0004170 ! small conjugating protein ligase activity [Term] id: CCO:F0008369 name: 4-aminobutyrate:2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate." [EC:2.6.1.19, GOC:mah] synonym: "4-aminobutanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyrate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyrate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyrate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-ketoglutaric acid transaminase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19] xref: GO:0034386 is_a: CCO:F0000386 ! 4-aminobutyrate transaminase activity [Term] id: CCO:F0008370 name: 4-aminobutyrate:pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine." [EC:2.6.1.19, GOC:mah] synonym: "gamma-aminobutyric acid pyruvate transaminase activity" EXACT [EC:2.6.1.19] xref: GO:0034387 is_a: CCO:F0000386 ! 4-aminobutyrate transaminase activity [Term] id: CCO:F0008371 name: ISG15 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins." [GOC:mah, PMID:12826404] synonym: "ISG15 conjugating enzyme activity" EXACT [] xref: GO:0042296 is_a: CCO:F0004170 ! small conjugating protein ligase activity [Term] id: CCO:F0008372 name: 2,3-dihydroxybiphenyl 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid." [GOC:jl, PMID:15715866] subset: gosubset_prok synonym: "2,3-dihydroxybiphenyl-1,2-dioxygenase activity" EXACT [] synonym: "BphC" RELATED [] xref: GO:0043898 is_a: CCO:F0003286 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: CCO:F0008373 name: bisphosphoglycerate 2-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 3-phosphoglycerate + phosphate." [EC:3.1.3.13] synonym: "2,3-bisphospho-D-glycerate 2-phosphohydrolase activity" EXACT [EC:3.1.3.13] xref: EC:3.1.3.13 xref: GO:0004083 xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN is_a: CCO:F0000558 ! bisphosphoglycerate phosphatase activity [Term] id: CCO:F0008374 name: protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] subset: gosubset_prok synonym: "protein-tyrosine kinase activity" EXACT [] xref: EC:2.7.10 xref: GO:0004713 xref: MetaCyc:PROTEIN-TYROSINE-KINASE-RXN xref: Reactome:11065 is_a: CCO:F0001043 ! protein kinase activity [Term] id: CCO:F0008375 name: metalloenzyme regulator activity namespace: molecular_function def: "Modulates the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:dph, GOC:tb] xref: GO:0010576 is_a: CCO:F0004354 ! enzyme regulator activity [Term] id: CCO:F0008376 name: metalloenzyme activitor activity namespace: molecular_function def: "Increases the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:dph, GOC:tb] xref: GO:0010577 is_a: CCO:F0001691 ! enzyme activator activity is_a: CCO:F0008375 ! metalloenzyme regulator activity [Term] id: CCO:F0008377 name: bisphosphoglycerate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phosphoglycerate + phosphate." [EC:3.1.3.13, GOC:mah, PMID:18413611] synonym: "2,3-bisphospho-D-glycerate 3-phosphohydrolase activity" EXACT [EC:3.1.3.13] xref: GO:0034417 is_a: CCO:F0000558 ! bisphosphoglycerate phosphatase activity [Term] id: CCO:F0008378 name: L-2-hydroxyglutarate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2." [PMID:18390652] xref: GO:0034419 is_a: CCO:F0008250 ! (S)-2-hydroxy-acid oxidase activity [Term] id: CCO:F0008379 name: bis(5'-adenosyl)-hexaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008] synonym: "AP(6)A hydrolase activity" EXACT [] synonym: "AP-6-A hydrolase activity" EXACT [] synonym: "AP6A hydrolase activity" EXACT [] synonym: "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity" EXACT [] xref: GO:0034431 is_a: CCO:F0000937 ! nucleotide diphosphatase activity [Term] id: CCO:F0008380 name: bis(5'-adenosyl)-pentaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate." [PMID:10085096, PMID:9450008] synonym: "AP(5)A hydrolase activity" EXACT [] synonym: "AP-5-A hydrolase activity" EXACT [] synonym: "AP5A hydrolase activity" EXACT [] synonym: "diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity" EXACT [] xref: GO:0034432 is_a: CCO:F0000937 ! nucleotide diphosphatase activity [Term] id: CCO:F0008381 name: glycoprotein transporter activity namespace: molecular_function def: "Enables the directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid, into, out of, within or between cells." [GOC:mah, GOC:rl] xref: GO:0034437 is_a: CCO:F0001997 ! protein transporter activity [Term] id: CCO:F0008382 name: phosphoserine:homoserine phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine." [GOC:jl, PMID:14699121] subset: gosubset_prok synonym: "thrH" RELATED [] xref: EC:2.7.1 xref: GO:0043899 xref: IMG:02616 is_a: CCO:F0003345 ! phosphotransferase activity, alcohol group as acceptor [Term] id: CCO:G0003992 name: YWHAB_human def: "14-3-3 protein beta/alpha gene" [UniProtKB:P31946] xref: EMBL:AL008725 xref: EMBL:BC001359 xref: EMBL:X57346 xref: HGNC:HGNC:12849 xref: UniGene:Hs.651212 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005480 ! 1433B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0003993 name: YWHAE_human def: "14-3-3 protein epsilon gene" [UniProtKB:P62258] xref: EMBL:AB017103 xref: EMBL:BC000179 xref: EMBL:BC001440 xref: EMBL:BT007161 xref: EMBL:CH471108 xref: EMBL:U20972 xref: EMBL:U28936 xref: EMBL:U43399 xref: EMBL:U43430 xref: EMBL:U54778 xref: HGNC:HGNC:12851 xref: UniGene:Hs.513851 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005488 ! 1433E_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0003994 name: YWHAH_human def: "14-3-3 protein eta gene" [UniProtKB:Q04917] synonym: "YWHA1" EXACT [UniProtKB:Q04917] xref: EMBL:BC003047 xref: EMBL:CR456612 xref: EMBL:D78577 xref: EMBL:L20422 xref: EMBL:S80794 xref: EMBL:X57345 xref: EMBL:X78138 xref: EMBL:X80536 xref: EMBL:Z82248 xref: HGNC:HGNC:12853 xref: UniGene:Hs.226755 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005490 ! 1433F_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0003995 name: YWHAG_human def: "14-3-3 protein gamma gene" [UniProtKB:P61981] xref: EMBL:AB024334 xref: EMBL:AC006388 xref: EMBL:AF142498 xref: EMBL:BC020963 xref: EMBL:CR541904 xref: EMBL:CR541925 xref: HGNC:HGNC:12852 xref: UniGene:Hs.520974 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005489 ! 1433G_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0003996 name: SFN_human def: "14-3-3 protein sigma gene" [UniProtKB:P31947] synonym: "HME1" EXACT [UniProtKB:P31947] xref: EMBL:AF029081 xref: EMBL:AF029082 xref: EMBL:AL034380 xref: EMBL:BC000329 xref: EMBL:BC000995 xref: EMBL:BC001550 xref: EMBL:BC002995 xref: EMBL:BC023552 xref: EMBL:CR541905 xref: EMBL:CR541926 xref: EMBL:M93010 xref: EMBL:X57348 xref: HGNC:HGNC:10773 xref: UniGene:Hs.523718 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001584 ! 1433S_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0003997 name: YWHAQ_human def: "14-3-3 protein theta gene" [UniProtKB:P27348] xref: EMBL:AF070556 xref: EMBL:BC001197 xref: EMBL:BC050601 xref: EMBL:BC056867 xref: EMBL:BC093019 xref: EMBL:BT020014 xref: EMBL:X56468 xref: EMBL:X57347 xref: HGNC:HGNC:12854 xref: UniGene:Hs.74405 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001559 ! 1433T_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0003998 name: YWHAZ_human def: "14-3-3 protein zeta/delta gene" [UniProtKB:P63104] xref: EMBL:BC003623 xref: EMBL:BC051814 xref: EMBL:BC063824 xref: EMBL:BC068456 xref: EMBL:BC072426 xref: EMBL:BC073141 xref: EMBL:BC083508 xref: EMBL:BC099904 xref: EMBL:BC101483 xref: EMBL:BC108281 xref: EMBL:BC111951 xref: EMBL:M86400 xref: EMBL:U28964 xref: HGNC:HGNC:12855 xref: UniGene:Hs.492407 xref: UniGene:Hs.594673 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005413 ! 1433Z_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0003999 name: PPP2R5A_human def: "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform gene" [UniProtKB:Q15172] xref: EMBL:AL360091 xref: EMBL:AL451060 xref: EMBL:BC022474 xref: EMBL:BC110883 xref: EMBL:L42373 xref: HGNC:HGNC:9309 xref: UniGene:Hs.497684 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005516 ! 2A5A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004000 name: PPP2R5D_human def: "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform gene" [UniProtKB:Q14738] xref: EMBL:AB000634 xref: EMBL:AB000635 xref: EMBL:BC001095 xref: EMBL:BC001175 xref: EMBL:BC010692 xref: EMBL:D78360 xref: EMBL:L76702 xref: HGNC:HGNC:9312 xref: UniGene:Hs.533308 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005515 ! 2A5D_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004001 name: PPP2R5E_human def: "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform gene" [UniProtKB:Q16537] xref: EMBL:BC093766 xref: EMBL:L76703 xref: EMBL:Z69029 xref: HGNC:HGNC:9313 xref: UniGene:Hs.334868 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005518 ! 2A5E_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004003 name: PPP2R1B_human def: "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform gene" [UniProtKB:P30154] xref: EMBL:AF083425 xref: EMBL:AF083426 xref: EMBL:AF083427 xref: EMBL:AF083428 xref: EMBL:AF083429 xref: EMBL:AF083430 xref: EMBL:AF083431 xref: EMBL:AF083432 xref: EMBL:AF083433 xref: EMBL:AF083434 xref: EMBL:AF083435 xref: EMBL:AF083436 xref: EMBL:AF083437 xref: EMBL:AF083438 xref: EMBL:AF083439 xref: EMBL:AF087438 xref: EMBL:AF163473 xref: EMBL:M65254 xref: HGNC:HGNC:9303 xref: UniGene:Hs.584790 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005517 ! 2AAB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004004 name: EIF4ENIF1_human def: "Eukaryotic translation initiation factor 4E transporter gene" [UniProtKB:Q9NRA8] xref: EMBL:AF240775 xref: EMBL:AK025254 xref: EMBL:AK074768 xref: EMBL:BC032941 xref: EMBL:BC033028 xref: EMBL:CR456386 xref: HGNC:HGNC:16687 xref: UniGene:Hs.517559 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006012 ! 4ET_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004005 name: SLC3A2_human def: "4F2 cell-surface antigen heavy chain gene" [UniProtKB:P08195] synonym: "MDU1" EXACT [UniProtKB:P08195] xref: EMBL:AB018010 xref: EMBL:BC001061 xref: EMBL:BC003000 xref: EMBL:J02769 xref: EMBL:J02939 xref: EMBL:J03569 xref: EMBL:M21898 xref: EMBL:M21899 xref: EMBL:M21900 xref: EMBL:M21901 xref: EMBL:M21902 xref: EMBL:M21903 xref: EMBL:M21904 xref: HGNC:HGNC:11026 xref: UniGene:Hs.502769 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005463 ! 4F2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004007 name: APP_human def: "Amyloid beta A4 protein precursor gene" [UniProtKB:P05067] synonym: "A4" EXACT [UniProtKB:P05067] synonym: "AD1" EXACT [UniProtKB:P05067] xref: EMBL:AF282245 xref: EMBL:AY919674 xref: EMBL:BC004369 xref: EMBL:D87675 xref: EMBL:M15532 xref: EMBL:M15533 xref: EMBL:M16765 xref: EMBL:M18734 xref: EMBL:M24546 xref: EMBL:M24547 xref: EMBL:M28373 xref: EMBL:M29269 xref: EMBL:M29270 xref: EMBL:M33112 xref: EMBL:M34862 xref: EMBL:M34863 xref: EMBL:M34864 xref: EMBL:M34865 xref: EMBL:M34866 xref: EMBL:M34867 xref: EMBL:M34868 xref: EMBL:M34869 xref: EMBL:M34870 xref: EMBL:M34871 xref: EMBL:M34872 xref: EMBL:M34873 xref: EMBL:M34874 xref: EMBL:M34875 xref: EMBL:M34876 xref: EMBL:M34877 xref: EMBL:M34878 xref: EMBL:M34879 xref: EMBL:M35675 xref: EMBL:M37895 xref: EMBL:M37896 xref: EMBL:S45136 xref: EMBL:S60317 xref: EMBL:S60721 xref: EMBL:S61380 xref: EMBL:S61383 xref: EMBL:X06981 xref: EMBL:X06982 xref: EMBL:X06989 xref: EMBL:X13466 xref: EMBL:X13467 xref: EMBL:X13468 xref: EMBL:X13469 xref: EMBL:X13470 xref: EMBL:X13471 xref: EMBL:X13472 xref: EMBL:X13473 xref: EMBL:X13474 xref: EMBL:X13475 xref: EMBL:X13476 xref: EMBL:X13477 xref: EMBL:X13478 xref: EMBL:X13479 xref: EMBL:X13487 xref: EMBL:X13488 xref: EMBL:Y00264 xref: HGNC:HGNC:620 xref: UniGene:Hs.434980 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005474 ! A4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004008 name: PRKAA1_human def: "5'-AMP-activated protein kinase catalytic subunit alpha-1 gene" [UniProtKB:Q13131] synonym: "AMPK1" EXACT [UniProtKB:Q13131] xref: EMBL:AB022017 xref: EMBL:AF100763 xref: EMBL:BC037303 xref: EMBL:U22456 xref: EMBL:Y12856 xref: HGNC:HGNC:9376 xref: UniGene:Hs.43322 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005872 ! AAPK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004009 name: AATF_human def: "Protein AATF gene" [UniProtKB:Q9NY61] synonym: "CHE1" EXACT [UniProtKB:Q9NY61] synonym: "DED" EXACT [UniProtKB:Q9NY61] synonym: "HSPC277" EXACT [UniProtKB:Q9NY61] xref: EMBL:AC003103 xref: EMBL:AF083208 xref: EMBL:AF161395 xref: EMBL:AJ249940 xref: EMBL:BC000591 xref: EMBL:CH471199 xref: HGNC:HGNC:19235 xref: UniGene:Hs.195740 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005446 ! AATF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004011 name: ABCD4_human def: "ATP-binding cassette sub-family D member 4 gene" [UniProtKB:O14678] synonym: "PXMP1L" EXACT [UniProtKB:O14678] xref: EMBL:AF009746 xref: EMBL:BC012815 xref: EMBL:BT007412 xref: EMBL:CR457104 xref: EMBL:Y14318 xref: EMBL:Y14319 xref: EMBL:Y14320 xref: EMBL:Y14321 xref: EMBL:Y14322 xref: EMBL:Y14323 xref: HGNC:HGNC:68 xref: UniGene:Hs.94395 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006268 ! ABCD4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004012 name: ABI1_human def: "Abl interactor 1 gene" [UniProtKB:Q8IZP0] synonym: "SSH3BP1" EXACT [UniProtKB:Q8IZP0] xref: EMBL:AB040151 xref: EMBL:AF001628 xref: EMBL:AF006516 xref: EMBL:AF260262 xref: EMBL:AF540955 xref: EMBL:AJ277065 xref: EMBL:AJ277066 xref: EMBL:AJ277067 xref: EMBL:AJ277068 xref: EMBL:AJ277069 xref: EMBL:AJ277070 xref: EMBL:AJ277071 xref: EMBL:AJ277072 xref: EMBL:AJ277073 xref: EMBL:AJ277074 xref: EMBL:AL139404 xref: EMBL:AL390961 xref: EMBL:BC024254 xref: EMBL:U87166 xref: HGNC:HGNC:11320 xref: UniGene:Hs.508148 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005703 ! ABI1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004013 name: ABL1_human def: "Proto-oncogene tyrosine-protein kinase ABL1 gene" [UniProtKB:P00519] synonym: "ABL" EXACT [UniProtKB:P00519] synonym: "JTK7" EXACT [UniProtKB:P00519] xref: EMBL:DQ145721 xref: EMBL:M14752 xref: EMBL:S69223 xref: EMBL:U07561 xref: EMBL:U07563 xref: EMBL:X16416 xref: HGNC:HGNC:76 xref: UniGene:Hs.431048 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001461 ! ABL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004015 name: ACD_human def: "Adrenocortical dysplasia protein homolog gene" [UniProtKB:Q96AP0] synonym: "PIP1" EXACT [UniProtKB:Q96AP0] synonym: "PTOP" EXACT [UniProtKB:Q96AP0] xref: EMBL:AK023726 xref: EMBL:AY502940 xref: EMBL:AY971883 xref: EMBL:BC016904 xref: HGNC:HGNC:25070 xref: UniGene:Hs.78019 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005504 ! ACD_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004016 name: TNK2_human def: "Activated CDC42 kinase 1 gene" [UniProtKB:Q07912] synonym: "ACK1" EXACT [UniProtKB:Q07912] xref: EMBL:AK131539 xref: EMBL:BC008884 xref: EMBL:BC028164 xref: EMBL:L13738 xref: HGNC:HGNC:19297 xref: UniGene:Hs.518513 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005836 ! ACK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004017 name: ACTL6A_human def: "Actin-like protein 6A gene" [UniProtKB:O96019] synonym: "BAF53" EXACT [UniProtKB:O96019] synonym: "BAF53A" EXACT [UniProtKB:O96019] xref: EMBL:AB015907 xref: EMBL:AB060168 xref: EMBL:AB061315 xref: EMBL:AF041474 xref: EMBL:AL136608 xref: EMBL:BC000949 xref: EMBL:BC001391 xref: EMBL:BC036371 xref: HGNC:HGNC:24124 xref: UniGene:Hs.435326 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005366 ! ACL6A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004018 name: ACSS2_human def: "Acetyl-coenzyme A synthetase, cytoplasmic gene" [UniProtKB:Q9NR19] synonym: "ACAS2" EXACT [UniProtKB:Q9NR19] xref: EMBL:AF263614 xref: EMBL:AL049709 xref: EMBL:AL133324 xref: EMBL:BC012172 xref: HGNC:HGNC:15814 xref: UniGene:Hs.517034 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005570 ! ACSA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004019 name: ACTA2_human def: "Actin, aortic smooth muscle gene" [UniProtKB:P62736] synonym: "ACTSA" EXACT [UniProtKB:P62736] synonym: "ACTVS" EXACT [UniProtKB:P62736] synonym: "GIG46" EXACT [UniProtKB:P62736] xref: EMBL:AL157394 xref: EMBL:AY692464 xref: EMBL:BC017554 xref: EMBL:BC093052 xref: EMBL:CR536518 xref: EMBL:J05192 xref: EMBL:K01741 xref: EMBL:K01742 xref: EMBL:K01743 xref: EMBL:M33216 xref: EMBL:X13839 xref: HGNC:HGNC:130 xref: UniGene:Hs.500483 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005810 ! ACTA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004020 name: ACTB_human def: "Actin, cytoplasmic 1 gene" [UniProtKB:P60709] xref: EMBL:AC006483 xref: EMBL:AY582799 xref: EMBL:BC001301 xref: EMBL:BC002409 xref: EMBL:BC004251 xref: EMBL:BC013380 xref: EMBL:BC014861 xref: EMBL:BC016045 xref: EMBL:M10277 xref: EMBL:V00478 xref: EMBL:X00351 xref: EMBL:X63432 xref: HGNC:HGNC:132 xref: UniGene:Hs.520640 xref: UniGene:Hs.702191 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005775 ! ACTB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004021 name: ACTN1_human def: "Alpha-actinin-1 gene" [UniProtKB:P12814] xref: EMBL:BC003576 xref: EMBL:BC015766 xref: EMBL:BT007207 xref: EMBL:M95178 xref: EMBL:X15804 xref: EMBL:X55187 xref: HGNC:HGNC:163 xref: UniGene:Hs.509765 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005948 ! ACTN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004022 name: ACTN2_human def: "Alpha-actinin-2 gene" [UniProtKB:P35609] xref: EMBL:AJ249756 xref: EMBL:AJ249757 xref: EMBL:AJ249758 xref: EMBL:AJ249759 xref: EMBL:AJ249760 xref: EMBL:AJ249761 xref: EMBL:AJ249762 xref: EMBL:AJ249763 xref: EMBL:AJ249764 xref: EMBL:AJ249765 xref: EMBL:AJ249766 xref: EMBL:AJ249767 xref: EMBL:AJ249768 xref: EMBL:AJ249769 xref: EMBL:AJ249770 xref: EMBL:AJ249771 xref: EMBL:AJ249772 xref: EMBL:AJ249773 xref: EMBL:AJ249774 xref: EMBL:AJ249775 xref: EMBL:AJ249776 xref: EMBL:BC047901 xref: EMBL:BC051770 xref: EMBL:M86406 xref: EMBL:M86804 xref: HGNC:HGNC:164 xref: UniGene:Hs.498178 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005642 ! ACTN2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004024 name: ACVR1B_human def: "Activin receptor type-1B precursor gene" [UniProtKB:P36896] synonym: "ACVRLK4" EXACT [UniProtKB:P36896] xref: EMBL:BC000254 xref: EMBL:BC040531 xref: EMBL:BT007072 xref: EMBL:L10125 xref: EMBL:L10126 xref: EMBL:L31848 xref: EMBL:U14722 xref: EMBL:Z22536 xref: HGNC:HGNC:172 xref: UniGene:Hs.438918 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001597 ! ACV1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004025 name: ACVR1_human def: "Activin receptor type-1 precursor gene" [UniProtKB:Q04771] synonym: "ACVRLK2" EXACT [UniProtKB:Q04771] xref: EMBL:BC033867 xref: EMBL:L02911 xref: EMBL:Z22534 xref: HGNC:HGNC:171 xref: UniGene:Hs.470316 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001720 ! ACVR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004026 name: ADAM15_human def: "ADAM 15 precursor gene" [UniProtKB:Q13444] synonym: "MDC15" EXACT [UniProtKB:Q13444] xref: EMBL:AF314227 xref: EMBL:AY560594 xref: EMBL:BC014566 xref: EMBL:BT009764 xref: EMBL:U41767 xref: EMBL:U46005 xref: HGNC:HGNC:193 xref: UniGene:Hs.312098 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005909 ! ADA15_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004027 name: ADAM17_human def: "ADAM 17 precursor gene" [UniProtKB:P78536] synonym: "CSVP" EXACT [UniProtKB:P78536] synonym: "TACE" EXACT [UniProtKB:P78536] xref: EMBL:U69611 xref: EMBL:U69612 xref: EMBL:U86755 xref: EMBL:U92649 xref: HGNC:HGNC:195 xref: UniGene:Hs.404914 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005712 ! ADA17_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004029 name: ADAM9_human def: "ADAM 9 precursor gene" [UniProtKB:Q13443] synonym: "KIAA0021" EXACT [UniProtKB:Q13443] synonym: "MCMP" EXACT [UniProtKB:Q13443] synonym: "MDC9" EXACT [UniProtKB:Q13443] synonym: "MLTNG" EXACT [UniProtKB:Q13443] xref: EMBL:AF495383 xref: EMBL:D14665 xref: EMBL:U41766 xref: HGNC:HGNC:216 xref: UniGene:Hs.591852 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005372 ! ADAM9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004032 name: SLC25A5_human def: "ADP/ATP translocase 2 gene" [UniProtKB:P05141] synonym: "ANT2" EXACT [UniProtKB:P05141] xref: EMBL:AC004000 xref: EMBL:BC056160 xref: EMBL:J02683 xref: EMBL:J03591 xref: EMBL:L78810 xref: EMBL:M57424 xref: HGNC:HGNC:10991 xref: UniGene:Hs.644618 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005813 ! ADT2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004033 name: AES_human def: "Amino-terminal enhancer of split gene" [UniProtKB:Q08117] synonym: "GRG" EXACT [UniProtKB:Q08117] xref: EMBL:AC005944 xref: EMBL:AF072902 xref: EMBL:U04241 xref: EMBL:U88831 xref: EMBL:U88832 xref: EMBL:X73358 xref: HGNC:HGNC:307 xref: UniGene:Hs.515053 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005987 ! AES_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004034 name: AFAP1L2_human def: "Actin filament-associated protein 1-like 2 gene" [UniProtKB:Q8N4X5] synonym: "KIAA1914" EXACT [UniProtKB:Q8N4X5] xref: EMBL:AB067501 xref: EMBL:AC005383 xref: EMBL:AK027470 xref: EMBL:AL133384 xref: EMBL:AL355302 xref: EMBL:BC024314 xref: EMBL:BC033212 xref: HGNC:HGNC:25901 xref: UniGene:Hs.501106 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001964 ! AF1L2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004035 name: MLLT3_human def: "Protein AF-9 gene" [UniProtKB:P42568] synonym: "AF9" EXACT [UniProtKB:P42568] synonym: "YEATS3" EXACT [UniProtKB:P42568] xref: EMBL:BC036089 xref: EMBL:L13744 xref: HGNC:HGNC:7136 xref: UniGene:Hs.591085 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005303 ! Q8IVB0_HUMAN relationship: codes_for CCO:B0006206 ! AF9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004038 name: AHR_human def: "Aryl hydrocarbon receptor precursor gene" [UniProtKB:P35869] xref: EMBL:AC003075 xref: EMBL:BC069390 xref: EMBL:BC070080 xref: EMBL:D16354 xref: EMBL:D38044 xref: EMBL:L19872 xref: EMBL:U27656 xref: EMBL:U27657 xref: EMBL:U28060 xref: EMBL:U28061 xref: EMBL:U28062 xref: EMBL:U28063 xref: EMBL:U28064 xref: EMBL:U28065 xref: EMBL:U28066 xref: HGNC:HGNC:348 xref: UniGene:Hs.171189 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001595 ! AHR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004039 name: AIF1_human def: "Allograft inflammatory factor 1 gene" [UniProtKB:P55008] synonym: "G1" EXACT [UniProtKB:P55008] synonym: "IBA1" EXACT [UniProtKB:P55008] xref: EMBL:AF129756 xref: EMBL:AL662801 xref: EMBL:AL662847 xref: EMBL:AL805934 xref: EMBL:BA000025 xref: EMBL:BC009474 xref: EMBL:D86438 xref: EMBL:U19713 xref: EMBL:U49392 xref: EMBL:Y14768 xref: HGNC:HGNC:352 xref: UniGene:Hs.76364 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001673 ! AIF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004040 name: AIP_human def: "AH receptor-interacting protein gene" [UniProtKB:O00170] synonym: "XAP2" EXACT [UniProtKB:O00170] xref: EMBL:AM236341 xref: EMBL:BC104797 xref: EMBL:BC104827 xref: EMBL:U31913 xref: EMBL:U78521 xref: HGNC:HGNC:358 xref: UniGene:Hs.412433 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005380 ! AIP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004041 name: AKR1C3_human def: "Aldo-keto reductase family 1 member C3 gene" [UniProtKB:P42330] synonym: "DDH1" EXACT [UniProtKB:P42330] synonym: "HSD17B5" EXACT [UniProtKB:P42330] synonym: "KIAA0119" EXACT [UniProtKB:P42330] synonym: "PGFS" EXACT [UniProtKB:P42330] xref: EMBL:AB018580 xref: EMBL:AB028065 xref: EMBL:AB032157 xref: EMBL:AF149416 xref: EMBL:AL391427 xref: EMBL:BC001479 xref: EMBL:BC019230 xref: EMBL:BT007286 xref: EMBL:D17793 xref: EMBL:L43831 xref: EMBL:L43832 xref: EMBL:L43833 xref: EMBL:L43834 xref: EMBL:L43835 xref: EMBL:L43836 xref: EMBL:L43837 xref: EMBL:L43838 xref: EMBL:L43839 xref: EMBL:S68288 xref: HGNC:HGNC:386 xref: UniGene:Hs.78183 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006117 ! AK1C3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004042 name: AKAP8_human def: "A-kinase anchor protein 8 gene" [UniProtKB:O43823] synonym: "AKAP95" EXACT [UniProtKB:O43823] xref: EMBL:AC005785 xref: EMBL:Y11997 xref: HGNC:HGNC:378 xref: UniGene:Hs.631640 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001399 ! AKAP8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004043 name: AKAP9_human def: "A-kinase anchor protein 9 gene" [UniProtKB:Q99996] synonym: "AKAP350" EXACT [UniProtKB:Q99996] synonym: "AKAP450" EXACT [UniProtKB:Q99996] synonym: "KIAA0803" EXACT [UniProtKB:Q99996] xref: EMBL:AB018346 xref: EMBL:AB019691 xref: EMBL:AC000066 xref: EMBL:AC000120 xref: EMBL:AC004013 xref: EMBL:AF026245 xref: EMBL:AF083037 xref: EMBL:AF091711 xref: EMBL:AJ010770 xref: EMBL:AJ131693 xref: HGNC:HGNC:379 xref: UniGene:Hs.651221 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005588 ! AKAP9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004044 name: AURKAIP1_human def: "Aurora kinase A-interacting protein gene" [UniProtKB:Q9NWT8] synonym: "AIP" EXACT [UniProtKB:Q9NWT8] synonym: "AKIP" EXACT [UniProtKB:Q9NWT8] xref: EMBL:AK000615 xref: EMBL:AL139287 xref: EMBL:BC022808 xref: EMBL:BC062333 xref: HGNC:HGNC:24114 xref: UniGene:Hs.515704 xref: UniGene:Hs.632515 xref: UniGene:Hs.658138 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002171 ! AKIP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004045 name: AKT1_human def: "RAC-alpha serine/threonine-protein kinase gene" [UniProtKB:P31749] synonym: "PKB" EXACT [UniProtKB:P31749] synonym: "RAC" EXACT [UniProtKB:P31749] xref: EMBL:AF283819 xref: EMBL:AF283820 xref: EMBL:AF283821 xref: EMBL:AF283822 xref: EMBL:AF283823 xref: EMBL:AF283824 xref: EMBL:AF283825 xref: EMBL:AF283826 xref: EMBL:AF283827 xref: EMBL:AF283828 xref: EMBL:AF283829 xref: EMBL:AF283830 xref: EMBL:BC000479 xref: EMBL:BC084538 xref: EMBL:M63167 xref: EMBL:X61037 xref: HGNC:HGNC:391 xref: UniGene:Hs.525622 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005512 ! AKT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004046 name: AKT2_human def: "RAC-beta serine/threonine-protein kinase gene" [UniProtKB:P31751] xref: EMBL:AY708392 xref: EMBL:BC120994 xref: EMBL:M77198 xref: EMBL:M95936 xref: HGNC:HGNC:392 xref: UniGene:Hs.631535 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005910 ! AKT2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004047 name: AKT3_human def: "RAC-gamma serine/threonine-protein kinase gene" [UniProtKB:Q9Y243] synonym: "PKBG" EXACT [UniProtKB:Q9Y243] xref: EMBL:AC096539 xref: EMBL:AF085234 xref: EMBL:AF124141 xref: EMBL:AF135794 xref: EMBL:AJ245709 xref: EMBL:AL117525 xref: EMBL:AL591721 xref: EMBL:AL592151 xref: EMBL:AL662889 xref: EMBL:AY005799 xref: EMBL:BC121154 xref: EMBL:CH471148 xref: HGNC:HGNC:393 xref: UniGene:Hs.498292 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005911 ! AKT3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004048 name: ALS2CR2_human def: "Pseudokinase ALS2CR2 gene" [UniProtKB:Q9C0K7] synonym: "ILPIP" EXACT [UniProtKB:Q9C0K7] synonym: "PRO1038" EXACT [UniProtKB:Q9C0K7] xref: EMBL:AB038950 xref: EMBL:AC007282 xref: EMBL:AF116618 xref: EMBL:AK027637 xref: EMBL:AY093697 xref: EMBL:BC008302 xref: EMBL:BC090871 xref: HGNC:HGNC:13205 xref: UniGene:Hs.652338 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002119 ! AL2S2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004049 name: ALK_human def: "ALK tyrosine kinase receptor precursor gene" [UniProtKB:Q9UM73] xref: EMBL:AB209477 xref: EMBL:AC074096 xref: EMBL:AC093756 xref: EMBL:AC106870 xref: EMBL:U62540 xref: EMBL:U66559 xref: HGNC:HGNC:427 xref: UniGene:Hs.654469 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005628 ! ALK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004050 name: AMOTL2_human def: "Angiomotin-like protein 2 gene" [UniProtKB:Q9Y2J4] synonym: "KIAA0989" EXACT [UniProtKB:Q9Y2J4] xref: EMBL:AB023206 xref: EMBL:AF175966 xref: EMBL:AK223598 xref: EMBL:BC011454 xref: HGNC:HGNC:17812 xref: UniGene:Hs.426312 xref: UniGene:Hs.705466 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005299 ! AMOL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004051 name: LRPAP1_human def: "Alpha-2-macroglobulin receptor-associated protein precursor gene" [UniProtKB:P30533] synonym: "A2MRAP" EXACT [UniProtKB:P30533] xref: EMBL:AF035760 xref: EMBL:AF035761 xref: EMBL:AF035762 xref: EMBL:AF035763 xref: EMBL:AF035764 xref: EMBL:AF035765 xref: EMBL:AF035766 xref: EMBL:AF035767 xref: EMBL:AK222504 xref: EMBL:AK222527 xref: EMBL:AL590235 xref: EMBL:BC105074 xref: EMBL:BC112067 xref: EMBL:M63959 xref: EMBL:U06976 xref: HGNC:HGNC:6701 xref: UniGene:Hs.533136 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006334 ! AMRP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004052 name: ANP32A_human def: "Acidic leucine-rich nuclear phosphoprotein 32 family member A gene" [UniProtKB:P39687] synonym: "C15orf1" EXACT [UniProtKB:P39687] synonym: "LANP" EXACT [UniProtKB:P39687] synonym: "MAPM" EXACT [UniProtKB:P39687] synonym: "PHAP1" EXACT [UniProtKB:P39687] xref: EMBL:AF025684 xref: EMBL:BC007200 xref: EMBL:BT007436 xref: EMBL:U60823 xref: EMBL:U73477 xref: EMBL:X75090 xref: HGNC:HGNC:13233 xref: UniGene:Hs.458747 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006073 ! AN32A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004053 name: ANAPC13_human def: "Anaphase-promoting complex subunit 13 gene" [UniProtKB:Q9BS18] xref: EMBL:AL050051 xref: EMBL:BC005398 xref: HGNC:HGNC:24540 xref: UniGene:Hs.106909 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002095 ! APC13_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004054 name: ANAPC1_human def: "Anaphase-promoting complex subunit 1 gene" [UniProtKB:Q9H1A4] synonym: "TSG24" EXACT [UniProtKB:Q9H1A4] xref: EMBL:AJ278357 xref: EMBL:AK023807 xref: EMBL:BC005089 xref: EMBL:BC104902 xref: EMBL:BC104904 xref: HGNC:HGNC:19988 xref: UniGene:Hs.436527 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002125 ! APC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004055 name: ANAPC2_human def: "Anaphase-promoting complex subunit 2 gene" [UniProtKB:Q9UJX6] synonym: "APC2" EXACT [UniProtKB:Q9UJX6] synonym: "KIAA1406" EXACT [UniProtKB:Q9UJX6] xref: EMBL:AB037827 xref: EMBL:AF191337 xref: EMBL:AL929554 xref: EMBL:BC001579 xref: EMBL:BC009487 xref: EMBL:BC032503 xref: HGNC:HGNC:19989 xref: UniGene:Hs.533262 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002216 ! ANC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004056 name: ANAPC4_human def: "Anaphase-promoting complex subunit 4 gene" [UniProtKB:Q9UJX5] synonym: "APC4" EXACT [UniProtKB:Q9UJX5] xref: EMBL:AF191338 xref: EMBL:AL353932 xref: HGNC:HGNC:19990 xref: UniGene:Hs.152173 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002215 ! APC4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004057 name: ANAPC5_human def: "Anaphase-promoting complex subunit 5 gene" [UniProtKB:Q9UJX4] synonym: "APC5" EXACT [UniProtKB:Q9UJX4] xref: EMBL:AF191339 xref: EMBL:BC001081 xref: EMBL:BC001950 xref: EMBL:BC006301 xref: EMBL:BC034243 xref: EMBL:BX537687 xref: HGNC:HGNC:15713 xref: UniGene:Hs.7101 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002214 ! APC5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004058 name: AR_human def: "Androgen receptor gene" [UniProtKB:P10275] synonym: "DHTR" EXACT [UniProtKB:P10275] synonym: "NR3C4" EXACT [UniProtKB:P10275] xref: EMBL:L29496 xref: EMBL:M20132 xref: EMBL:M20260 xref: EMBL:M21748 xref: EMBL:M23263 xref: EMBL:M27423 xref: EMBL:M27424 xref: EMBL:M27425 xref: EMBL:M27426 xref: EMBL:M27427 xref: EMBL:M27428 xref: EMBL:M27429 xref: EMBL:M27430 xref: EMBL:M34233 xref: EMBL:M35844 xref: EMBL:M35845 xref: EMBL:M35846 xref: EMBL:M35847 xref: EMBL:M35848 xref: EMBL:M35849 xref: EMBL:M35850 xref: EMBL:M35851 xref: EMBL:S79366 xref: EMBL:U16371 xref: HGNC:HGNC:644 xref: UniGene:Hs.496240 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005356 ! ANDR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004059 name: ANG_human def: "Angiogenin precursor gene" [UniProtKB:P03950] synonym: "RNASE5" EXACT [UniProtKB:P03950] xref: EMBL:AF449647 xref: EMBL:AF449648 xref: EMBL:AF449649 xref: EMBL:AF449650 xref: EMBL:AF449651 xref: EMBL:BC054880 xref: EMBL:M11567 xref: HGNC:HGNC:483 xref: UniGene:Hs.283749 xref: UniGene:Hs.706192 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006220 ! ANGI_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004060 name: ANKS3_human def: "Ankyrin repeat and SAM domain-containing protein 3 gene" [UniProtKB:Q6ZW76] synonym: "KIAA1977" EXACT [UniProtKB:Q6ZW76] xref: EMBL:AB075857 xref: EMBL:AK123496 xref: HGNC:HGNC:29422 xref: UniGene:Hs.654859 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005965 ! ANKS3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004061 name: ANKZF1_human def: "Ankyrin repeat and zinc finger domain-containing protein 1 gene" [UniProtKB:Q9H8Y5] synonym: "ZNF744" EXACT [UniProtKB:Q9H8Y5] xref: EMBL:AK001277 xref: EMBL:AK023206 xref: EMBL:BC000238 xref: EMBL:BC008948 xref: EMBL:DQ412564 xref: HGNC:HGNC:25527 xref: UniGene:Hs.437647 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006329 ! ANKZ1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004062 name: ANLN_human def: "Actin-binding protein anillin gene" [UniProtKB:Q9NQW6] xref: EMBL:AF273437 xref: EMBL:AK001468 xref: EMBL:AK001472 xref: EMBL:AK023208 xref: EMBL:BC034692 xref: EMBL:BC070066 xref: EMBL:CR936650 xref: HGNC:HGNC:14082 xref: UniGene:Hs.62180 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002155 ! ANLN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004063 name: PRMT1_human def: "Protein arginine N-methyltransferase 1 gene" [UniProtKB:Q99873] synonym: "HMT2" EXACT [UniProtKB:Q99873] synonym: "HRMT1L2" EXACT [UniProtKB:Q99873] synonym: "IR1B4" EXACT [UniProtKB:Q99873] xref: EMBL:AF222689 xref: EMBL:D66904 xref: EMBL:Y10805 xref: EMBL:Y10806 xref: EMBL:Y10807 xref: HGNC:HGNC:5187 xref: UniGene:Hs.20521 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005713 ! ANM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004064 name: PRMT2_human def: "Protein arginine N-methyltransferase 2 gene" [UniProtKB:P55345] synonym: "HMT1" EXACT [UniProtKB:P55345] synonym: "HRMT1L1" EXACT [UniProtKB:P55345] xref: EMBL:AL109794 xref: EMBL:BC000727 xref: EMBL:U80213 xref: EMBL:X99209 xref: HGNC:HGNC:5186 xref: UniGene:Hs.154163 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005630 ! ANM2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004065 name: PRMT5_human def: "Protein arginine N-methyltransferase 5 gene" [UniProtKB:O14744] synonym: "HRMT1L5" EXACT [UniProtKB:O14744] synonym: "IBP72" EXACT [UniProtKB:O14744] synonym: "JBP1" EXACT [UniProtKB:O14744] synonym: "SKB1" EXACT [UniProtKB:O14744] xref: EMBL:AF015913 xref: EMBL:AF167572 xref: EMBL:BC025979 xref: EMBL:CR456741 xref: HGNC:HGNC:10894 xref: UniGene:Hs.367854 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001357 ! ANM5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004068 name: ANXA1_human def: "Annexin A1 gene" [UniProtKB:P04083] synonym: "ANX1" EXACT [UniProtKB:P04083] synonym: "LPC1" EXACT [UniProtKB:P04083] xref: EMBL:BC001275 xref: EMBL:BC035993 xref: EMBL:X05908 xref: HGNC:HGNC:533 xref: UniGene:Hs.494173 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001479 ! ANXA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004069 name: ANXA2_human def: "Annexin A2 gene" [UniProtKB:P07355] synonym: "ANX2" EXACT [UniProtKB:P07355] synonym: "ANX2L4" EXACT [UniProtKB:P07355] synonym: "CAL1H" EXACT [UniProtKB:P07355] synonym: "LPC2D" EXACT [UniProtKB:P07355] xref: EMBL:BC001388 xref: EMBL:BC009564 xref: EMBL:BC015834 xref: EMBL:BC016774 xref: EMBL:BC021114 xref: EMBL:BC052558 xref: EMBL:BC052567 xref: EMBL:BC066955 xref: EMBL:BC068065 xref: EMBL:BC093056 xref: EMBL:BT007432 xref: EMBL:D00017 xref: HGNC:HGNC:537 xref: UniGene:Hs.511605 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005736 ! ANXA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004070 name: ANXA3_human def: "Annexin A3 gene" [UniProtKB:P12429] synonym: "ANX3" EXACT [UniProtKB:P12429] xref: EMBL:BC000871 xref: EMBL:CR407648 xref: EMBL:L20591 xref: EMBL:M20560 xref: EMBL:M63310 xref: HGNC:HGNC:541 xref: UniGene:Hs.480042 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006119 ! ANXA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004071 name: ANXA6_human def: "Annexin A6 gene" [UniProtKB:P08133] synonym: "ANX6" EXACT [UniProtKB:P08133] xref: EMBL:AK126836 xref: EMBL:BC017046 xref: EMBL:D00510 xref: EMBL:J03578 xref: EMBL:Y00097 xref: HGNC:HGNC:544 xref: UniGene:Hs.412117 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005731 ! ANXA6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004072 name: TFAP2A_human def: "Transcription factor AP-2 alpha gene" [UniProtKB:P05549] synonym: "AP2TF" EXACT [UniProtKB:P05549] synonym: "TFAP2" EXACT [UniProtKB:P05549] xref: EMBL:M36711 xref: EMBL:M61156 xref: EMBL:X52611 xref: EMBL:X77343 xref: HGNC:HGNC:11742 xref: UniGene:Hs.519880 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005640 ! AP2A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004073 name: AP2B1_human def: "AP-2 complex subunit beta-1 gene" [UniProtKB:P63010] synonym: "ADTB2" EXACT [UniProtKB:P63010] synonym: "CLAPB1" EXACT [UniProtKB:P63010] xref: EMBL:AC006237 xref: EMBL:BC006201 xref: EMBL:CH471147 xref: EMBL:M34175 xref: HGNC:HGNC:563 xref: UniGene:Hs.514819 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005197 ! AP2B1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004074 name: TFAP2B_human def: "Transcription factor AP-2 beta gene" [UniProtKB:Q92481] xref: EMBL:AJ278356 xref: EMBL:AL031224 xref: EMBL:AL049693 xref: EMBL:BC037225 xref: EMBL:X95694 xref: EMBL:Y09912 xref: HGNC:HGNC:11743 xref: UniGene:Hs.33102 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005680 ! AP2B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004075 name: TFAP2C_human def: "Transcription factor AP-2 gamma gene" [UniProtKB:Q92754] xref: EMBL:AB041717 xref: EMBL:AJ315934 xref: EMBL:AL121920 xref: EMBL:BC035664 xref: EMBL:BC051829 xref: EMBL:U85658 xref: EMBL:X95693 xref: HGNC:HGNC:11744 xref: UniGene:Hs.473152 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005377 ! AP2C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004076 name: APBB1_human def: "Amyloid beta A4 precursor protein-binding family B member 1 gene" [UniProtKB:O00213] synonym: "FE65" EXACT [UniProtKB:O00213] synonym: "RIR" EXACT [UniProtKB:O00213] xref: EMBL:AF029234 xref: EMBL:AF047835 xref: EMBL:AF394214 xref: EMBL:BC010854 xref: EMBL:L77864 xref: HGNC:HGNC:581 xref: UniGene:Hs.372840 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001344 ! APBB1_HUMAN relationship: codes_for CCO:B0001998 ! Q8TEY4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004077 name: APBB2_human def: "Amyloid beta A4 precursor protein-binding family B member 2 gene" [UniProtKB:Q92870] synonym: "FE65L" EXACT [UniProtKB:Q92870] synonym: "FE65L1" EXACT [UniProtKB:Q92870] xref: EMBL:BC027946 xref: EMBL:U62325 xref: HGNC:HGNC:582 xref: UniGene:Hs.479602 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002020 ! APBB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004078 name: ANAPC10_human def: "Anaphase-promoting complex subunit 10 gene" [UniProtKB:Q9UM13] synonym: "APC10" EXACT [UniProtKB:Q9UM13] xref: EMBL:AB012109 xref: EMBL:AF132794 xref: EMBL:AL080090 xref: EMBL:BC005217 xref: EMBL:DQ304649 xref: HGNC:HGNC:24077 xref: UniGene:Hs.480876 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002230 ! APC10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004079 name: ANAPC11_human def: "Anaphase-promoting complex subunit 11 gene" [UniProtKB:Q9NYG5] synonym: "HSPC214" EXACT [UniProtKB:Q9NYG5] xref: EMBL:AF151048 xref: EMBL:AF247565 xref: EMBL:AF247789 xref: EMBL:BC000607 xref: EMBL:BC066308 xref: EMBL:BC095454 xref: EMBL:BC104641 xref: HGNC:HGNC:14452 xref: UniGene:Hs.534456 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002177 ! APC11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004080 name: ANAPC7_human def: "Anaphase-promoting complex subunit 7 gene" [UniProtKB:Q9UJX3] synonym: "APC7" EXACT [UniProtKB:Q9UJX3] xref: EMBL:AF191340 xref: EMBL:AL137586 xref: EMBL:BC002941 xref: EMBL:BC009498 xref: EMBL:BC017316 xref: HGNC:HGNC:17380 xref: UniGene:Hs.529280 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002213 ! APC7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004081 name: APC_human def: "Adenomatous polyposis coli protein gene" [UniProtKB:P25054] synonym: "DP2.5" EXACT [UniProtKB:P25054] xref: EMBL:M73548 xref: EMBL:M74088 xref: EMBL:S78214 xref: HGNC:HGNC:583 xref: UniGene:Hs.158932 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001556 ! APC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004082 name: APLP1_human def: "Amyloid-like protein 1 precursor gene" [UniProtKB:P51693] xref: EMBL:AD000864 xref: EMBL:BC012889 xref: EMBL:U48437 xref: HGNC:HGNC:597 xref: UniGene:Hs.74565 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006179 ! APLP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004083 name: APLP2_human def: "Amyloid-like protein 2 precursor gene" [UniProtKB:Q06481] synonym: "APPL2" EXACT [UniProtKB:Q06481] xref: EMBL:AF168956 xref: EMBL:BC000373 xref: EMBL:BC004371 xref: EMBL:L09209 xref: EMBL:L19597 xref: EMBL:L23113 xref: EMBL:L23114 xref: EMBL:L27631 xref: EMBL:S60099 xref: EMBL:Z22572 xref: HGNC:HGNC:598 xref: UniGene:Hs.370247 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005374 ! APLP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004086 name: APTX_human def: "Aprataxin gene" [UniProtKB:Q7Z2E3] synonym: "AXA1" EXACT [UniProtKB:Q7Z2E3] xref: EMBL:AJ565850 xref: EMBL:AJ565851 xref: EMBL:AJ565852 xref: EMBL:AJ565853 xref: EMBL:AJ565854 xref: EMBL:AJ565855 xref: EMBL:AJ575566 xref: EMBL:AK000164 xref: EMBL:AL353717 xref: EMBL:AY040777 xref: EMBL:AY208829 xref: EMBL:AY208830 xref: EMBL:AY208831 xref: EMBL:AY208832 xref: EMBL:AY208833 xref: EMBL:AY208834 xref: EMBL:AY208835 xref: EMBL:AY208836 xref: EMBL:AY208837 xref: EMBL:AY208838 xref: EMBL:AY208839 xref: EMBL:AY208840 xref: EMBL:AY208841 xref: EMBL:AY208842 xref: EMBL:BC001628 xref: EMBL:BX538161 xref: HGNC:HGNC:15984 xref: UniGene:Hs.20158 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005943 ! APTX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004087 name: ARAF_human def: "A-Raf proto-oncogene serine/threonine-protein kinase gene" [UniProtKB:P10398] synonym: "ARAF1" EXACT [UniProtKB:P10398] synonym: "PKS" EXACT [UniProtKB:P10398] synonym: "PKS2" EXACT [UniProtKB:P10398] xref: EMBL:BC002466 xref: EMBL:BT019864 xref: EMBL:L24038 xref: EMBL:M13829 xref: EMBL:U01337 xref: EMBL:X04790 xref: EMBL:Z84466 xref: HGNC:HGNC:646 xref: UniGene:Hs.446641 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005708 ! ARAF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004088 name: ARD1A_human def: "N-terminal acetyltransferase complex ARD1 subunit homolog A gene" [UniProtKB:P41227] synonym: "ARD1" EXACT [UniProtKB:P41227] synonym: "TE2" EXACT [UniProtKB:P41227] xref: EMBL:BC000308 xref: EMBL:BC019312 xref: EMBL:X77588 xref: HGNC:HGNC:18704 xref: UniGene:Hs.433291 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005243 ! ARD1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004089 name: ARFGAP1_human def: "ADP-ribosylation factor GTPase-activating protein 1 gene" [UniProtKB:Q8N6T3] synonym: "ARF1GAP" EXACT [UniProtKB:Q8N6T3] xref: EMBL:AB015340 xref: EMBL:AK001629 xref: EMBL:AK027268 xref: EMBL:AK027441 xref: EMBL:AL121827 xref: EMBL:AL137744 xref: EMBL:BC000786 xref: EMBL:BC006085 xref: EMBL:BC011876 xref: EMBL:BC028233 xref: HGNC:HGNC:15852 xref: UniGene:Hs.25584 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006225 ! ARFG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004091 name: ARID1A_human def: "AT-rich interactive domain-containing protein 1A gene" [UniProtKB:O14497] synonym: "C1orf4" EXACT [UniProtKB:O14497] synonym: "OSA1" EXACT [UniProtKB:O14497] synonym: "SMARCF1" EXACT [UniProtKB:O14497] xref: EMBL:AB001895 xref: EMBL:AB024075 xref: EMBL:AF219114 xref: EMBL:AF231056 xref: EMBL:AF265208 xref: EMBL:AF268913 xref: EMBL:AF521670 xref: EMBL:AK223275 xref: EMBL:AL034380 xref: EMBL:AL512408 xref: HGNC:HGNC:11110 xref: UniGene:Hs.468972 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006007 ! ARI1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004092 name: ARIH2_human def: "Protein ariadne-2 homolog gene" [UniProtKB:O95376] synonym: "ARI2" EXACT [UniProtKB:O95376] synonym: "HT005" EXACT [UniProtKB:O95376] synonym: "TRIAD1" EXACT [UniProtKB:O95376] xref: EMBL:AF099149 xref: EMBL:AF183427 xref: EMBL:AJ130978 xref: EMBL:BC000422 xref: HGNC:HGNC:690 xref: UniGene:Hs.649132 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005288 ! ARI2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004093 name: ARID4A_human def: "AT-rich interactive domain-containing protein 4A gene" [UniProtKB:P29374] synonym: "RBBP1" EXACT [UniProtKB:P29374] synonym: "RBP1" EXACT [UniProtKB:P29374] xref: EMBL:S57153 xref: EMBL:S57160 xref: EMBL:S57162 xref: EMBL:S66427 xref: HGNC:HGNC:9885 xref: UniGene:Hs.161000 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005693 ! ARI4A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004094 name: ARID2_human def: "AT-rich interactive domain-containing protein 2 gene" [UniProtKB:Q68CP9] synonym: "KIAA1557" EXACT [UniProtKB:Q68CP9] xref: EMBL:AB046777 xref: EMBL:AK027718 xref: EMBL:AK127872 xref: EMBL:AL832200 xref: EMBL:AY727870 xref: EMBL:BC090062 xref: EMBL:BX537879 xref: EMBL:CR749833 xref: EMBL:DQ096628 xref: HGNC:HGNC:18037 xref: UniGene:Hs.696080 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005497 ! ARID2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004095 name: ARL3_human def: "ADP-ribosylation factor-like protein 3 gene" [UniProtKB:P36405] synonym: "ARFL3" EXACT [UniProtKB:P36405] xref: EMBL:AF493889 xref: EMBL:BC009841 xref: EMBL:U07151 xref: HGNC:HGNC:694 xref: UniGene:Hs.182215 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006120 ! ARL3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004096 name: ARL4D_human def: "ADP-ribosylation factor-like protein 4D gene" [UniProtKB:P49703] synonym: "ARF4L" EXACT [UniProtKB:P49703] xref: EMBL:AB060692 xref: EMBL:BC000043 xref: EMBL:L38490 xref: EMBL:U25771 xref: HGNC:HGNC:656 xref: UniGene:Hs.183153 xref: UniGene:Hs.705646 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006256 ! ARL4D_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004097 name: ARL8B_human def: "ADP-ribosylation factor-like protein 8B gene" [UniProtKB:Q9NVJ2] synonym: "ARL10C" EXACT [UniProtKB:Q9NVJ2] synonym: "GIE1" EXACT [UniProtKB:Q9NVJ2] xref: EMBL:AB118751 xref: EMBL:AK001564 xref: EMBL:BC013131 xref: EMBL:BC063125 xref: EMBL:CR457264 xref: HGNC:HGNC:25564 xref: UniGene:Hs.250009 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006324 ! ARL8B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004098 name: ARNT2_human def: "Aryl hydrocarbon receptor nuclear translocator 2 gene" [UniProtKB:Q9HBZ2] synonym: "KIAA0307" EXACT [UniProtKB:Q9HBZ2] xref: EMBL:AB002305 xref: EMBL:AF185593 xref: EMBL:AF185594 xref: EMBL:AF185595 xref: EMBL:AF185596 xref: EMBL:AF185597 xref: EMBL:AF185598 xref: EMBL:AF185599 xref: EMBL:AF185600 xref: EMBL:AF185601 xref: EMBL:AF185602 xref: EMBL:AF185603 xref: EMBL:AF185604 xref: EMBL:AF185605 xref: EMBL:AF185606 xref: EMBL:AF185607 xref: EMBL:AF185608 xref: EMBL:AF185609 xref: EMBL:AF185610 xref: EMBL:BC036099 xref: HGNC:HGNC:16876 xref: UniGene:Hs.459070 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006033 ! ARNT2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004099 name: ARNT_human def: "Aryl hydrocarbon receptor nuclear translocator gene" [UniProtKB:P27540] xref: EMBL:AJ251863 xref: EMBL:AJ404851 xref: EMBL:AJ404852 xref: EMBL:AJ404853 xref: EMBL:AJ404854 xref: EMBL:AY430083 xref: EMBL:M69238 xref: EMBL:Y18859 xref: HGNC:HGNC:700 xref: UniGene:Hs.632446 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005551 ! ARNT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004100 name: ACTR6_human def: "Actin-related protein 6 gene" [UniProtKB:Q9GZN1] synonym: "CDA12" EXACT [UniProtKB:Q9GZN1] xref: EMBL:AB038229 xref: EMBL:AF212251 xref: EMBL:AK023495 xref: EMBL:AK023684 xref: EMBL:BC015107 xref: HGNC:HGNC:24025 xref: UniGene:Hs.115088 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005367 ! ARP6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004101 name: ACTR8_human def: "Actin-related protein 8 gene" [UniProtKB:Q9H981] xref: EMBL:AK022996 xref: EMBL:AK026232 xref: HGNC:HGNC:14672 xref: UniGene:Hs.412186 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006058 ! ARP8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004102 name: ARPC3_human def: "Actin-related protein 2/3 complex subunit 3 gene" [UniProtKB:O15145] synonym: "ARC21" EXACT [UniProtKB:O15145] xref: EMBL:AF004561 xref: EMBL:AF006086 xref: EMBL:BC067747 xref: EMBL:BC078162 xref: EMBL:CR407667 xref: HGNC:HGNC:706 xref: UniGene:Hs.524741 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006172 ! ARPC3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004105 name: PYCARD_human def: "Apoptosis-associated speck-like protein containing a CARD gene" [UniProtKB:Q9ULZ3] synonym: "ASC" EXACT [UniProtKB:Q9ULZ3] synonym: "CARD5" EXACT [UniProtKB:Q9ULZ3] synonym: "TMS1" EXACT [UniProtKB:Q9ULZ3] xref: EMBL:AB023416 xref: EMBL:AF184072 xref: EMBL:AF184073 xref: EMBL:AF255794 xref: EMBL:AF310103 xref: EMBL:AF384665 xref: EMBL:AK000211 xref: EMBL:BC004470 xref: EMBL:BC013569 xref: HGNC:HGNC:16608 xref: UniGene:Hs.499094 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002228 ! ASC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004106 name: ASF1A_human def: "Histone chaperone ASF1A gene" [UniProtKB:Q9Y294] synonym: "CGI-98" EXACT [UniProtKB:Q9Y294] synonym: "HSPC146" EXACT [UniProtKB:Q9Y294] xref: EMBL:AB028628 xref: EMBL:AF151856 xref: EMBL:AF161495 xref: EMBL:AF279306 xref: EMBL:AK025738 xref: EMBL:AL050261 xref: EMBL:BC010878 xref: EMBL:CR457347 xref: HGNC:HGNC:20995 xref: UniGene:Hs.292316 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005268 ! ASF1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004107 name: ASH2L_human def: "Set1/Ash2 histone methyltransferase complex subunit ASH2 gene" [UniProtKB:Q9UBL3] synonym: "ASH2L1" EXACT [UniProtKB:Q9UBL3] xref: EMBL:AB020982 xref: EMBL:AB022785 xref: EMBL:AF056717 xref: EMBL:AF056718 xref: EMBL:BC015936 xref: HGNC:HGNC:744 xref: UniGene:Hs.521530 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005614 ! ASH2L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004108 name: ASPM_human def: "Abnormal spindle-like microcephaly-associated protein gene" [UniProtKB:Q8IZT6] synonym: "MCPH5" EXACT [UniProtKB:Q8IZT6] xref: EMBL:AF509326 xref: EMBL:AK001379 xref: EMBL:AK001411 xref: EMBL:AY099890 xref: EMBL:AY099891 xref: EMBL:AY099892 xref: EMBL:AY099893 xref: EMBL:AY101201 xref: EMBL:AY367065 xref: EMBL:BC015396 xref: EMBL:BC034607 xref: HGNC:HGNC:19048 xref: UniGene:Hs.121028 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001956 ! ASPM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004109 name: PPP1R13B_human def: "Apoptosis-stimulating of p53 protein 1 gene" [UniProtKB:Q96KQ4] synonym: "ASPP1" EXACT [UniProtKB:Q96KQ4] synonym: "KIAA0771" EXACT [UniProtKB:Q96KQ4] xref: EMBL:AB018314 xref: EMBL:AJ318887 xref: EMBL:AL049840 xref: HGNC:HGNC:14950 xref: UniGene:Hs.436113 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002046 ! ASPP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004110 name: TP53BP2_human def: "Apoptosis-stimulating of p53 protein 2 gene" [UniProtKB:Q13625] synonym: "ASPP2" EXACT [UniProtKB:Q13625] synonym: "BBP" EXACT [UniProtKB:Q13625] xref: EMBL:AJ318888 xref: EMBL:BC046150 xref: EMBL:BC058918 xref: EMBL:U09582 xref: EMBL:U58334 xref: HGNC:HGNC:12000 xref: UniGene:Hs.523968 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001764 ! ASPP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004111 name: ATP1A1_human def: "Sodium/potassium-transporting ATPase subunit alpha-1 precursor gene" [UniProtKB:P05023] xref: EMBL:AL136376 xref: EMBL:BC001330 xref: EMBL:BC003077 xref: EMBL:BC050359 xref: EMBL:D00099 xref: EMBL:J03007 xref: EMBL:L76938 xref: EMBL:M16793 xref: EMBL:M16794 xref: EMBL:M27572 xref: EMBL:M27579 xref: EMBL:M30309 xref: EMBL:M30310 xref: EMBL:U16798 xref: EMBL:X03757 xref: EMBL:X04297 xref: HGNC:HGNC:799 xref: UniGene:Hs.371889 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005459 ! AT1A1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004112 name: ATP1B1_human def: "Sodium/potassium-transporting ATPase subunit beta-1 gene" [UniProtKB:P05026] synonym: "ATP1B" EXACT [UniProtKB:P05026] xref: EMBL:AL031726 xref: EMBL:BC000006 xref: EMBL:BT009787 xref: EMBL:M25160 xref: EMBL:M25161 xref: EMBL:U16799 xref: EMBL:X03747 xref: EMBL:X17161 xref: HGNC:HGNC:804 xref: UniGene:Hs.291196 xref: UniGene:Hs.702359 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005453 ! AT1B1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004113 name: ATP2A2_human def: "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 gene" [UniProtKB:P16615] synonym: "ATP2B" EXACT [UniProtKB:P16615] xref: EMBL:BC035588 xref: EMBL:M23114 xref: EMBL:M23115 xref: EMBL:M23116 xref: EMBL:M23278 xref: HGNC:HGNC:812 xref: UniGene:Hs.506759 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005840 ! AT2A2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004114 name: ATF3_human def: "Cyclic AMP-dependent transcription factor ATF-3 gene" [UniProtKB:P18847] xref: EMBL:AY426987 xref: EMBL:BC006322 xref: EMBL:L19871 xref: HGNC:HGNC:785 xref: UniGene:Hs.460 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006121 ! ATF3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004116 name: ATF7_human def: "Cyclic AMP-dependent transcription factor ATF-7 gene" [UniProtKB:P17544] synonym: "ATFA" EXACT [UniProtKB:P17544] xref: EMBL:X52943 xref: EMBL:X57197 xref: HGNC:HGNC:792 xref: UniGene:Hs.12286 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006016 ! ATF7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004117 name: ATM_human def: "Serine-protein kinase ATM gene" [UniProtKB:Q13315] xref: EMBL:AY220758 xref: EMBL:U26455 xref: EMBL:U33841 xref: EMBL:U55704 xref: EMBL:U55705 xref: EMBL:U55707 xref: EMBL:U55708 xref: EMBL:U55709 xref: EMBL:U55710 xref: EMBL:U55711 xref: EMBL:U55712 xref: EMBL:U55713 xref: EMBL:U55714 xref: EMBL:U55715 xref: EMBL:U55716 xref: EMBL:U55717 xref: EMBL:U55718 xref: EMBL:U55719 xref: EMBL:U55720 xref: EMBL:U55721 xref: EMBL:U55722 xref: EMBL:U55723 xref: EMBL:U55724 xref: EMBL:U55725 xref: EMBL:U55726 xref: EMBL:U55727 xref: EMBL:U55728 xref: EMBL:U55729 xref: EMBL:U55730 xref: EMBL:U55731 xref: EMBL:U55732 xref: EMBL:U55733 xref: EMBL:U55734 xref: EMBL:U55735 xref: EMBL:U55736 xref: EMBL:U55737 xref: EMBL:U55738 xref: EMBL:U55739 xref: EMBL:U55740 xref: EMBL:U55741 xref: EMBL:U55742 xref: EMBL:U55743 xref: EMBL:U55744 xref: EMBL:U55745 xref: EMBL:U55746 xref: EMBL:U55747 xref: EMBL:U55748 xref: EMBL:U55749 xref: EMBL:U55750 xref: EMBL:U55751 xref: EMBL:U55752 xref: EMBL:U55753 xref: EMBL:U55754 xref: EMBL:U55755 xref: EMBL:U55756 xref: EMBL:U55757 xref: EMBL:U67092 xref: EMBL:U82828 xref: EMBL:X91196 xref: HGNC:HGNC:795 xref: UniGene:Hs.367437 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001750 ! ATM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004118 name: ATN1_human def: "Atrophin-1 gene" [UniProtKB:P54259] synonym: "D12S755E" EXACT [UniProtKB:P54259] synonym: "DRPLA" EXACT [UniProtKB:P54259] xref: EMBL:D31840 xref: EMBL:D38529 xref: EMBL:D63808 xref: EMBL:L10377 xref: EMBL:U23851 xref: EMBL:U47924 xref: HGNC:HGNC:3033 xref: UniGene:Hs.143766 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005944 ! ATN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004119 name: ATP5A1_human def: "ATP synthase subunit alpha, mitochondrial precursor gene" [UniProtKB:P25705] synonym: "ATP5A" EXACT [UniProtKB:P25705] synonym: "ATP5AL2" EXACT [UniProtKB:P25705] synonym: "ATPM" EXACT [UniProtKB:P25705] xref: EMBL:BC003119 xref: EMBL:BC007299 xref: EMBL:BC008028 xref: EMBL:BC011384 xref: EMBL:BC016046 xref: EMBL:BC019310 xref: EMBL:BC039135 xref: EMBL:BC064562 xref: EMBL:BC067385 xref: EMBL:BT007209 xref: EMBL:D14710 xref: EMBL:D28126 xref: EMBL:X59066 xref: EMBL:X65460 xref: HGNC:HGNC:823 xref: UniGene:Hs.298280 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005778 ! ATPA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004120 name: ATP5B_human def: "ATP synthase subunit beta, mitochondrial precursor gene" [UniProtKB:P06576] synonym: "ATPMB" EXACT [UniProtKB:P06576] synonym: "ATPSB" EXACT [UniProtKB:P06576] xref: EMBL:BC016512 xref: EMBL:D00022 xref: EMBL:M19482 xref: EMBL:M19483 xref: EMBL:M27132 xref: EMBL:X03559 xref: EMBL:X05606 xref: HGNC:HGNC:830 xref: UniGene:Hs.406510 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005827 ! ATPB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004121 name: ATP5C1_human def: "ATP synthase subunit gamma, mitochondrial precursor gene" [UniProtKB:P36542] synonym: "ATP5C" EXACT [UniProtKB:P36542] synonym: "ATP5CL1" EXACT [UniProtKB:P36542] xref: EMBL:AL158044 xref: EMBL:AL353754 xref: EMBL:BC000470 xref: EMBL:BC000931 xref: EMBL:BC013394 xref: EMBL:BC016812 xref: EMBL:BC020824 xref: EMBL:D16561 xref: EMBL:D16562 xref: EMBL:D16563 xref: HGNC:HGNC:833 xref: UniGene:Hs.271135 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006122 ! ATPG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004122 name: ATRIP_human def: "ATR-interacting protein gene" [UniProtKB:Q8WXE1] synonym: "AGS1" EXACT [UniProtKB:Q8WXE1] xref: EMBL:AF451323 xref: EMBL:AK022405 xref: EMBL:BC014153 xref: EMBL:BC020563 xref: EMBL:BC030597 xref: HGNC:HGNC:33499 xref: UniGene:Hs.694840 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002009 ! ATRIP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004123 name: ATRX_human def: "Transcriptional regulator ATRX gene" [UniProtKB:P46100] synonym: "RAD54L" EXACT [UniProtKB:P46100] synonym: "XH2" EXACT [UniProtKB:P46100] xref: EMBL:AB101681 xref: EMBL:AB101682 xref: EMBL:AB101683 xref: EMBL:AB101684 xref: EMBL:AB101685 xref: EMBL:AB101686 xref: EMBL:AB101687 xref: EMBL:AB101688 xref: EMBL:AB101689 xref: EMBL:AB101690 xref: EMBL:AB101691 xref: EMBL:AB101692 xref: EMBL:AB101693 xref: EMBL:AB101694 xref: EMBL:AB101695 xref: EMBL:AB101696 xref: EMBL:AB101697 xref: EMBL:AB101698 xref: EMBL:AB101699 xref: EMBL:AB101700 xref: EMBL:AB102641 xref: EMBL:AB208928 xref: EMBL:AB209545 xref: EMBL:AF000157 xref: EMBL:AF000158 xref: EMBL:AF000159 xref: EMBL:AF000160 xref: EMBL:AL109753 xref: EMBL:AL121874 xref: EMBL:L34363 xref: EMBL:U09820 xref: EMBL:U72904 xref: EMBL:U72905 xref: EMBL:U72907 xref: EMBL:U72908 xref: EMBL:U72909 xref: EMBL:U72910 xref: EMBL:U72911 xref: EMBL:U72912 xref: EMBL:U72913 xref: EMBL:U72914 xref: EMBL:U72915 xref: EMBL:U72916 xref: EMBL:U72917 xref: EMBL:U72918 xref: EMBL:U72919 xref: EMBL:U72920 xref: EMBL:U72921 xref: EMBL:U72922 xref: EMBL:U72923 xref: EMBL:U72924 xref: EMBL:U72925 xref: EMBL:U72926 xref: EMBL:U72927 xref: EMBL:U72928 xref: EMBL:U72929 xref: EMBL:U72930 xref: EMBL:U72931 xref: EMBL:U72932 xref: EMBL:U72933 xref: EMBL:U72934 xref: EMBL:U72935 xref: EMBL:U72936 xref: EMBL:U72937 xref: EMBL:U72938 xref: EMBL:U75653 xref: EMBL:U97080 xref: EMBL:U97081 xref: EMBL:U97082 xref: EMBL:U97083 xref: EMBL:U97084 xref: EMBL:U97085 xref: EMBL:U97086 xref: EMBL:U97087 xref: EMBL:U97088 xref: EMBL:U97089 xref: EMBL:U97090 xref: EMBL:U97091 xref: EMBL:U97092 xref: EMBL:U97093 xref: EMBL:U97094 xref: EMBL:U97095 xref: EMBL:U97096 xref: EMBL:U97097 xref: EMBL:U97098 xref: EMBL:U97099 xref: EMBL:U97100 xref: EMBL:U97101 xref: EMBL:U97102 xref: EMBL:U97103 xref: EMBL:X83753 xref: EMBL:Z84487 xref: HGNC:HGNC:886 xref: UniGene:Hs.533526 xref: UniGene:Hs.653797 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005879 ! ATRX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004124 name: ATR_human def: "Serine/threonine-protein kinase ATR gene" [UniProtKB:Q13535] synonym: "FRP1" EXACT [UniProtKB:Q13535] xref: EMBL:AF325699 xref: EMBL:U49844 xref: EMBL:U76308 xref: EMBL:Y09077 xref: HGNC:HGNC:882 xref: UniGene:Hs.271791 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001756 ! ATR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004125 name: ATXN10_human def: "Ataxin-10 gene" [UniProtKB:Q9UBB4] synonym: "SCA10" EXACT [UniProtKB:Q9UBB4] xref: EMBL:AF119662 xref: EMBL:AL050282 xref: EMBL:BC007508 xref: EMBL:CR456568 xref: EMBL:CR457381 xref: EMBL:Z84478 xref: EMBL:Z93784 xref: EMBL:Z95331 xref: HGNC:HGNC:10549 xref: UniGene:Hs.475125 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005816 ! ATX10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004126 name: ATXN1_human def: "Ataxin-1 gene" [UniProtKB:P54253] synonym: "ATX1" EXACT [UniProtKB:P54253] synonym: "SCA1" EXACT [UniProtKB:P54253] xref: EMBL:AL009031 xref: EMBL:S82497 xref: EMBL:X79204 xref: HGNC:HGNC:10548 xref: UniGene:Hs.434961 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005425 ! ATX1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004127 name: ATXN2_human def: "Ataxin-2 gene" [UniProtKB:Q99700] synonym: "ATX2" EXACT [UniProtKB:Q99700] synonym: "SCA2" EXACT [UniProtKB:Q99700] synonym: "TNRC13" EXACT [UniProtKB:Q99700] xref: EMBL:AK128613 xref: EMBL:U70323 xref: EMBL:Y08262 xref: HGNC:HGNC:10555 xref: UniGene:Hs.76253 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005988 ! ATX2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004128 name: ATXN7_human def: "Ataxin-7 gene" [UniProtKB:O15265] synonym: "SCA7" EXACT [UniProtKB:O15265] xref: EMBL:AA398030 xref: EMBL:AF032102 xref: EMBL:AF032103 xref: EMBL:AF032105 xref: EMBL:AJ000517 xref: HGNC:HGNC:10560 xref: UniGene:Hs.476595 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005945 ! ATX7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004129 name: AURKB_human def: "Serine/threonine-protein kinase 12 gene" [UniProtKB:Q96GD4] synonym: "AIK2" EXACT [UniProtKB:Q96GD4] synonym: "AIM1" EXACT [UniProtKB:Q96GD4] synonym: "ARK2" EXACT [UniProtKB:Q96GD4] synonym: "STK12" EXACT [UniProtKB:Q96GD4] xref: EMBL:AB011446 xref: EMBL:AB011450 xref: EMBL:AF004022 xref: EMBL:AF008552 xref: EMBL:AF015254 xref: EMBL:BC000442 xref: EMBL:BC009751 xref: EMBL:BC013300 xref: EMBL:BC080581 xref: EMBL:BT019534 xref: HGNC:HGNC:11390 xref: UniGene:Hs.442658 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002040 ! AURKB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004130 name: AURKC_human def: "Serine/threonine-protein kinase 13 gene" [UniProtKB:Q9UQB9] synonym: "AIE2" EXACT [UniProtKB:Q9UQB9] synonym: "AIK3" EXACT [UniProtKB:Q9UQB9] synonym: "STK13" EXACT [UniProtKB:Q9UQB9] xref: EMBL:AB017332 xref: EMBL:AC005261 xref: EMBL:AF054621 xref: EMBL:AF059681 xref: HGNC:HGNC:11391 xref: UniGene:Hs.98338 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002242 ! AURKC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004131 name: AVPI1_human def: "Arginine vasopressin-induced protein 1 gene" [UniProtKB:Q5T686] synonym: "NPD013" EXACT [UniProtKB:Q5T686] synonym: "PP5395" EXACT [UniProtKB:Q5T686] xref: EMBL:AF218019 xref: EMBL:AF241786 xref: EMBL:AK222493 xref: EMBL:AK223099 xref: EMBL:AL355315 xref: EMBL:BC000877 xref: HGNC:HGNC:30898 xref: UniGene:Hs.23918 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001879 ! AVPI1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004133 name: AXIN1_human def: "Axin-1 gene" [UniProtKB:O15169] synonym: "AXIN" EXACT [UniProtKB:O15169] xref: EMBL:AC005202 xref: EMBL:AE006463 xref: EMBL:AF009674 xref: EMBL:BC017447 xref: EMBL:BC044648 xref: EMBL:Z69667 xref: EMBL:Z99754 xref: HGNC:HGNC:903 xref: UniGene:Hs.592082 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001367 ! AXN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004135 name: BAK1_human def: "Bcl-2 homologous antagonist/killer gene" [UniProtKB:Q16611] synonym: "BAK" EXACT [UniProtKB:Q16611] synonym: "BCL2L7" EXACT [UniProtKB:Q16611] synonym: "CDN1" EXACT [UniProtKB:Q16611] xref: EMBL:AY260471 xref: EMBL:BC004431 xref: EMBL:D88397 xref: EMBL:U16811 xref: EMBL:U23765 xref: EMBL:X84213 xref: EMBL:Z93017 xref: HGNC:HGNC:949 xref: UniGene:Hs.485139 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005420 ! BAK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004136 name: BANP_human def: "Protein BANP gene" [UniProtKB:Q8N9N5] synonym: "SMAR1" EXACT [UniProtKB:Q8N9N5] xref: EMBL:AK000545 xref: EMBL:AK094158 xref: EMBL:BC009424 xref: HGNC:HGNC:13450 xref: UniGene:Hs.461705 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001971 ! BANP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004138 name: BARD1_human def: "BRCA1-associated RING domain protein 1 gene" [UniProtKB:Q99728] xref: EMBL:AC016708 xref: EMBL:AF038034 xref: EMBL:AF038035 xref: EMBL:AF038036 xref: EMBL:AF038037 xref: EMBL:AF038038 xref: EMBL:AF038039 xref: EMBL:AF038040 xref: EMBL:AF038041 xref: EMBL:AF038042 xref: EMBL:BC126426 xref: EMBL:U76638 xref: HGNC:HGNC:952 xref: UniGene:Hs.591642 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002086 ! BARD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004139 name: BAT2_human def: "Large proline-rich protein BAT2 gene" [UniProtKB:P48634] synonym: "G2" EXACT [UniProtKB:P48634] xref: EMBL:AB210034 xref: EMBL:AF129756 xref: EMBL:AL662801 xref: EMBL:AL662847 xref: EMBL:AL805934 xref: EMBL:BA000025 xref: EMBL:BC030127 xref: EMBL:BC032134 xref: EMBL:BC042295 xref: EMBL:BC060668 xref: EMBL:BX511262 xref: EMBL:CR749245 xref: EMBL:M33509 xref: EMBL:M33512 xref: EMBL:M33518 xref: EMBL:Z15025 xref: HGNC:HGNC:13918 xref: UniGene:Hs.123239 xref: UniGene:Hs.436093 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005898 ! BAT2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004140 name: BAT3_human def: "Large proline-rich protein BAT3 gene" [UniProtKB:P46379] synonym: "G3" EXACT [UniProtKB:P46379] xref: EMBL:AF129756 xref: EMBL:AL662801 xref: EMBL:AL662847 xref: EMBL:AL670886 xref: EMBL:AL805934 xref: EMBL:BA000025 xref: EMBL:BC003133 xref: EMBL:BX511262 xref: EMBL:BX647244 xref: EMBL:M33519 xref: EMBL:M33520 xref: EMBL:M33521 xref: HGNC:HGNC:13919 xref: UniGene:Hs.440900 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006127 ! BAT3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004141 name: BAT5_human def: "Protein BAT5 gene" [UniProtKB:O95870] synonym: "G5" EXACT [UniProtKB:O95870] synonym: "NG26" EXACT [UniProtKB:O95870] synonym: "PP199" EXACT [UniProtKB:O95870] xref: EMBL:AF129756 xref: EMBL:AF193047 xref: EMBL:AK001207 xref: EMBL:AK023194 xref: EMBL:AL662899 xref: EMBL:AL670886 xref: EMBL:AL805934 xref: EMBL:BA000025 xref: EMBL:BC031839 xref: EMBL:BX248244 xref: EMBL:BX511262 xref: HGNC:HGNC:13921 xref: UniGene:Hs.388188 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005571 ! BAT5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004142 name: BATF_human def: "Basic leucine zipper transcriptional factor ATF-like gene" [UniProtKB:Q16520] xref: EMBL:AC007182 xref: EMBL:AF016898 xref: EMBL:BC032294 xref: EMBL:D42106 xref: EMBL:U15460 xref: HGNC:HGNC:958 xref: UniGene:Hs.509964 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005320 ! BATF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004143 name: BAX_human def: "Apoptosis regulator BAX gene" [UniProtKB:Q07812] xref: EMBL:AF007826 xref: EMBL:AF250190 xref: EMBL:AJ417988 xref: EMBL:AY217036 xref: EMBL:BC014175 xref: EMBL:CH471177 xref: EMBL:L22473 xref: EMBL:L22474 xref: EMBL:L22475 xref: EMBL:U19599 xref: HGNC:HGNC:959 xref: UniGene:Hs.631546 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001723 ! BAX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004145 name: BCL11A_human def: "B-cell lymphoma/leukemia 11A gene" [UniProtKB:Q9H165] synonym: "CTIP1" EXACT [UniProtKB:Q9H165] synonym: "EVI9" EXACT [UniProtKB:Q9H165] synonym: "KIAA1809" EXACT [UniProtKB:Q9H165] xref: EMBL:AB058712 xref: EMBL:AF080216 xref: EMBL:AJ404611 xref: EMBL:AJ404612 xref: EMBL:AJ404613 xref: EMBL:AK001035 xref: EMBL:AY228763 xref: EMBL:BC021098 xref: HGNC:HGNC:13221 xref: UniGene:Hs.370549 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006020 ! BC11A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004146 name: BCAR1_human def: "Breast cancer anti-estrogen resistance protein 1 gene" [UniProtKB:P56945] synonym: "CAS" EXACT [UniProtKB:P56945] synonym: "CRKAS" EXACT [UniProtKB:P56945] xref: EMBL:AB040024 xref: EMBL:AF218451 xref: EMBL:AJ242987 xref: EMBL:AK027608 xref: HGNC:HGNC:971 xref: UniGene:Hs.479747 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005841 ! BCAR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004147 name: BCAR3_human def: "Breast cancer anti-estrogen resistance protein 3 gene" [UniProtKB:O75815] synonym: "NSP2" EXACT [UniProtKB:O75815] synonym: "SH2D3B" EXACT [UniProtKB:O75815] synonym: "UNQ271/PRO308" EXACT [UniProtKB:O75815] xref: EMBL:AF124250 xref: EMBL:AL109613 xref: EMBL:AL359820 xref: EMBL:AY358996 xref: EMBL:BC039895 xref: EMBL:U92715 xref: HGNC:HGNC:973 xref: UniGene:Hs.36958 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001437 ! BCAR3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004148 name: BCAT1_human def: "Branched-chain-amino-acid aminotransferase, cytosolic gene" [UniProtKB:P54687] synonym: "BCT1" EXACT [UniProtKB:P54687] synonym: "ECA39" EXACT [UniProtKB:P54687] xref: EMBL:AK056255 xref: EMBL:U21551 xref: HGNC:HGNC:976 xref: UniGene:Hs.438993 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001671 ! BCAT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004149 name: BCCIP_human def: "BRCA2 and CDKN1A-interacting protein gene" [UniProtKB:Q9P287] synonym: "TOK1" EXACT [UniProtKB:Q9P287] xref: EMBL:AB040450 xref: EMBL:AB040451 xref: EMBL:AL360176 xref: EMBL:AL834458 xref: EMBL:AY064247 xref: EMBL:AY064248 xref: EMBL:AY064249 xref: EMBL:BC009771 xref: HGNC:HGNC:978 xref: UniGene:Hs.370292 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002187 ! BCCIP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004150 name: BCL10_human def: "B-cell lymphoma/leukemia 10 gene" [UniProtKB:O95999] synonym: "CIPER" EXACT [UniProtKB:O95999] synonym: "CLAP" EXACT [UniProtKB:O95999] xref: EMBL:AF057700 xref: EMBL:AF082283 xref: EMBL:AF097732 xref: EMBL:AF100338 xref: EMBL:AF105066 xref: EMBL:AF127386 xref: EMBL:AF134395 xref: EMBL:AJ006288 xref: EMBL:BC053617 xref: HGNC:HGNC:989 xref: UniGene:Hs.193516 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001458 ! BCL10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004151 name: BCL2_human def: "Apoptosis regulator Bcl-2 gene" [UniProtKB:P10415] xref: EMBL:AY220759 xref: EMBL:BC027258 xref: EMBL:M13994 xref: EMBL:M13995 xref: EMBL:M14745 xref: EMBL:S72602 xref: EMBL:X06487 xref: HGNC:HGNC:990 xref: UniGene:Hs.150749 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001506 ! BCL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004152 name: BCL3_human def: "B-cell lymphoma 3-encoded protein gene" [UniProtKB:P20749] synonym: "BCL4" EXACT [UniProtKB:P20749] synonym: "D19S37" EXACT [UniProtKB:P20749] xref: EMBL:BC064993 xref: EMBL:M31731 xref: EMBL:M31732 xref: EMBL:U05681 xref: EMBL:U05822 xref: HGNC:HGNC:998 xref: UniGene:Hs.31210 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005513 ! BCL3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004153 name: BCL6_human def: "B-cell lymphoma 6 protein gene" [UniProtKB:P41182] synonym: "BCL5" EXACT [UniProtKB:P41182] synonym: "LAZ3" EXACT [UniProtKB:P41182] synonym: "ZBTB27" EXACT [UniProtKB:P41182] synonym: "ZNF51" EXACT [UniProtKB:P41182] xref: EMBL:S67779 xref: EMBL:U00115 xref: EMBL:Z21943 xref: HGNC:HGNC:1001 xref: UniGene:Hs.478588 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001603 ! BCL6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004154 name: BCL9_human def: "B-cell CLL/lymphoma 9 protein gene" [UniProtKB:O00512] xref: EMBL:Y13620 xref: HGNC:HGNC:1008 xref: UniGene:Hs.415209 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006061 ! BCL9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004155 name: BCL2L1_human def: "Apoptosis regulator Bcl-X gene" [UniProtKB:Q07817] synonym: "BCL2L" EXACT [UniProtKB:Q07817] synonym: "BCLX" EXACT [UniProtKB:Q07817] xref: EMBL:AL117381 xref: EMBL:AL160175 xref: EMBL:BC019307 xref: EMBL:BT007208 xref: EMBL:U72398 xref: EMBL:Z23115 xref: EMBL:Z23116 xref: HGNC:HGNC:992 xref: UniGene:Hs.516966 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005901 ! BCLX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004156 name: BCR_human def: "Breakpoint cluster region protein gene" [UniProtKB:P11274] synonym: "BCR1" EXACT [UniProtKB:P11274] synonym: "D22S11" EXACT [UniProtKB:P11274] xref: EMBL:AB209991 xref: EMBL:M15025 xref: EMBL:M64437 xref: EMBL:U07000 xref: EMBL:X02596 xref: EMBL:X14676 xref: EMBL:X52828 xref: EMBL:X52829 xref: EMBL:Y00661 xref: HGNC:HGNC:1014 xref: UniGene:Hs.517461 xref: UniGene:Hs.634378 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006123 ! BCR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004157 name: BECN1_human def: "Beclin-1 gene" [UniProtKB:Q14457] synonym: "GT197" EXACT [UniProtKB:Q14457] xref: EMBL:AF077301 xref: EMBL:AF139131 xref: EMBL:BC010276 xref: EMBL:L38932 xref: HGNC:HGNC:1034 xref: UniGene:Hs.12272 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005950 ! BECN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004158 name: BEGAIN_human def: "Brain-enriched guanylate kinase-associated protein gene" [UniProtKB:Q9BUH8] synonym: "KIAA1446" EXACT [UniProtKB:Q9BUH8] xref: EMBL:AB040879 xref: EMBL:AL390162 xref: EMBL:BC002607 xref: HGNC:HGNC:24163 xref: UniGene:Hs.211751 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005626 ! BEGIN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004159 name: BHLHB2_human def: "Class B basic helix-loop-helix protein 2 gene" [UniProtKB:O14503] synonym: "DEC1" EXACT [UniProtKB:O14503] synonym: "SHARP2" EXACT [UniProtKB:O14503] synonym: "STRA13" EXACT [UniProtKB:O14503] xref: EMBL:AB004066 xref: EMBL:AB043885 xref: EMBL:AF353634 xref: EMBL:AF353635 xref: EMBL:BC082238 xref: HGNC:HGNC:1046 xref: UniGene:Hs.171825 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005888 ! BHLH2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004163 name: BIN1_human def: "Myc box-dependent-interacting protein 1 gene" [UniProtKB:O00499] synonym: "AMPHL" EXACT [UniProtKB:O00499] xref: EMBL:AF001383 xref: EMBL:AF004015 xref: EMBL:AF043898 xref: EMBL:AF043899 xref: EMBL:AF043900 xref: EMBL:AF043901 xref: EMBL:AF068914 xref: EMBL:AF068915 xref: EMBL:AF068916 xref: EMBL:AF068917 xref: EMBL:AF068918 xref: EMBL:AF070576 xref: EMBL:U68485 xref: EMBL:U83999 xref: EMBL:U84001 xref: EMBL:U84002 xref: EMBL:U84003 xref: EMBL:U84004 xref: EMBL:U87558 xref: HGNC:HGNC:1052 xref: UniGene:Hs.193163 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001349 ! BIN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004164 name: BIN3_human def: "Bridging integrator 3 gene" [UniProtKB:Q9NQY0] xref: EMBL:AF271732 xref: EMBL:AK001289 xref: EMBL:AK023980 xref: EMBL:BC001223 xref: EMBL:BC009824 xref: HGNC:HGNC:1054 xref: UniGene:Hs.696034 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002156 ! BIN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004166 name: BIRC5_human def: "Baculoviral IAP repeat-containing protein 5 gene" [UniProtKB:O15392] synonym: "API4" EXACT [UniProtKB:O15392] synonym: "IAP4" EXACT [UniProtKB:O15392] xref: EMBL:AB028869 xref: EMBL:AB154416 xref: EMBL:AC087645 xref: EMBL:AF077350 xref: EMBL:AK223428 xref: EMBL:AY795969 xref: EMBL:AY830084 xref: EMBL:AY927772 xref: EMBL:BC008718 xref: EMBL:BC034148 xref: EMBL:BC065497 xref: EMBL:CR541740 xref: EMBL:DQ310375 xref: EMBL:DQ310376 xref: EMBL:DQ310377 xref: EMBL:DQ310378 xref: EMBL:DQ310379 xref: EMBL:U75285 xref: HGNC:HGNC:593 xref: UniGene:Hs.514527 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001377 ! BIRC5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004168 name: BLM_human def: "Bloom syndrome protein gene" [UniProtKB:P54132] synonym: "RECQ2" EXACT [UniProtKB:P54132] synonym: "RECQL3" EXACT [UniProtKB:P54132] xref: EMBL:AY886902 xref: EMBL:BC093622 xref: EMBL:BC101567 xref: EMBL:BC115030 xref: EMBL:BC115032 xref: EMBL:U39817 xref: HGNC:HGNC:1058 xref: UniGene:Hs.169348 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005502 ! BLM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004169 name: BMCC1_human def: "BNIP2 motif-containing molecule at the C-terminal region 1 gene" [UniProtKB:Q58A63] synonym: "BNIPXL" EXACT [UniProtKB:Q58A63] synonym: "KIAA0367" EXACT [UniProtKB:Q58A63] xref: EMBL:AB002365 xref: EMBL:AB050197 xref: EMBL:AL161626 xref: EMBL:AL359314 xref: EMBL:AY439213 xref: EMBL:AY439214 xref: EMBL:BC022571 xref: UniGene:Hs.262857 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001842 ! BMCC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004170 name: BMP2_human def: "Bone morphogenetic protein 2 precursor gene" [UniProtKB:P12643] synonym: "BMP2A" EXACT [UniProtKB:P12643] xref: EMBL:AF040249 xref: EMBL:AL035668 xref: EMBL:M22489 xref: HGNC:HGNC:1069 xref: UniGene:Hs.73853 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001515 ! BMP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004171 name: BMP4_human def: "Bone morphogenetic protein 4 precursor gene" [UniProtKB:P12644] synonym: "BMP2B" EXACT [UniProtKB:P12644] synonym: "DVR4" EXACT [UniProtKB:P12644] xref: EMBL:BC020546 xref: EMBL:D30751 xref: EMBL:M22490 xref: EMBL:U43842 xref: HGNC:HGNC:1071 xref: UniGene:Hs.68879 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001516 ! BMP4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004172 name: BMP7_human def: "Bone morphogenetic protein 7 precursor gene" [UniProtKB:P18075] synonym: "OP1" EXACT [UniProtKB:P18075] xref: EMBL:AL122058 xref: EMBL:AL157414 xref: EMBL:BC008584 xref: EMBL:M60316 xref: EMBL:X51801 xref: HGNC:HGNC:1074 xref: UniGene:Hs.473163 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001531 ! BMP7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004174 name: BMPR1A_human def: "Bone morphogenetic protein receptor type-1A precursor gene" [UniProtKB:P36894] synonym: "ACVRLK3" EXACT [UniProtKB:P36894] synonym: "ALK3" EXACT [UniProtKB:P36894] xref: EMBL:BC028383 xref: EMBL:Z22535 xref: HGNC:HGNC:1076 xref: UniGene:Hs.524477 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005437 ! BMR1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004175 name: BMX_human def: "Cytoplasmic tyrosine-protein kinase BMX gene" [UniProtKB:P51813] xref: EMBL:AC097625 xref: EMBL:AF045459 xref: EMBL:BC016652 xref: EMBL:CH471074 xref: EMBL:U08341 xref: EMBL:X83107 xref: HGNC:HGNC:1079 xref: UniGene:Hs.495731 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005923 ! BMX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004176 name: BNIP3L_human def: "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like gene" [UniProtKB:O60238] synonym: "BNIP3A" EXACT [UniProtKB:O60238] synonym: "BNIP3H" EXACT [UniProtKB:O60238] synonym: "NIX" EXACT [UniProtKB:O60238] xref: EMBL:AB004788 xref: EMBL:AF067396 xref: EMBL:AF079221 xref: EMBL:AF255051 xref: EMBL:AF452712 xref: EMBL:AF536326 xref: EMBL:BC001559 xref: EMBL:BC009603 xref: EMBL:BT019501 xref: HGNC:HGNC:1085 xref: UniGene:Hs.131226 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005714 ! BNI3L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004179 name: BOC_human def: "Brother of CDO precursor gene" [UniProtKB:Q9BWV1] synonym: "UNQ604/PRO1190" EXACT [UniProtKB:Q9BWV1] xref: EMBL:AK074556 xref: EMBL:AK090455 xref: EMBL:AY027658 xref: EMBL:AY358328 xref: HGNC:HGNC:17173 xref: UniGene:Hs.591318 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006259 ! BOC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004180 name: BOLL_human def: "Protein boule-like gene" [UniProtKB:Q8N9W6] synonym: "BOULE" EXACT [UniProtKB:Q8N9W6] xref: EMBL:AF272858 xref: EMBL:AK058099 xref: EMBL:AK093453 xref: EMBL:BC033674 xref: HGNC:HGNC:14273 xref: UniGene:Hs.169797 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001972 ! BOLL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004181 name: BORA_human def: "Protein aurora borealis gene" [UniProtKB:Q6PGQ7] synonym: "C13orf34" EXACT [UniProtKB:Q6PGQ7] xref: EMBL:AK026277 xref: EMBL:AL138695 xref: EMBL:BC007119 xref: EMBL:BC025367 xref: EMBL:BC044213 xref: EMBL:BC056876 xref: HGNC:HGNC:24724 xref: UniGene:Hs.705516 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001914 ! BORA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004182 name: CDCA8_human def: "Borealin gene" [UniProtKB:Q53HL2] synonym: "PESCRG3" EXACT [UniProtKB:Q53HL2] xref: EMBL:AK001330 xref: EMBL:AK022104 xref: EMBL:AK022606 xref: EMBL:AK222549 xref: EMBL:AK222568 xref: EMBL:AY508815 xref: EMBL:BC000703 xref: EMBL:BC001651 xref: EMBL:BC008079 xref: EMBL:BC016944 xref: EMBL:BG354581 xref: HGNC:HGNC:14629 xref: UniGene:Hs.702170 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001839 ! BOREA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004183 name: DST_human def: "Bullous pemphigoid antigen 1, isoforms 6/9/10 gene" [UniProtKB:O94833] synonym: "BPAG1" EXACT [UniProtKB:O94833] synonym: "DMH" EXACT [UniProtKB:O94833] synonym: "DT" EXACT [UniProtKB:O94833] synonym: "KIAA0728" EXACT [UniProtKB:O94833] xref: EMBL:AB018271 xref: EMBL:AF400226 xref: EMBL:AK055189 xref: EMBL:AK094883 xref: EMBL:AK096713 xref: EMBL:AL096710 xref: EMBL:AL137008 xref: EMBL:AL512422 xref: EMBL:AL512448 xref: EMBL:AL590005 xref: EMBL:BC004912 xref: EMBL:BC016991 xref: HGNC:HGNC:1090 xref: UniGene:Hs.631992 xref: UniGene:Hs.669931 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001443 ! BPAEA_HUMAN relationship: codes_for CCO:B0001884 ! Q5TBT1_HUMAN relationship: codes_for CCO:B0001885 ! Q5TBT2_HUMAN relationship: codes_for CCO:B0002096 ! Q9BSP9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004185 name: BRAP_human def: "BRCA1-associated protein gene" [UniProtKB:Q7Z569] synonym: "RNF52" EXACT [UniProtKB:Q7Z569] xref: EMBL:AF035620 xref: EMBL:AF035950 xref: EMBL:AY332222 xref: HGNC:HGNC:1099 xref: UniGene:Hs.577448 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005471 ! BRAP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004186 name: BRCA1_human def: "Breast cancer type 1 susceptibility protein gene" [UniProtKB:P38398] synonym: "RNF53" EXACT [UniProtKB:P38398] xref: EMBL:AY273801 xref: EMBL:L78833 xref: EMBL:U14680 xref: HGNC:HGNC:1100 xref: UniGene:Hs.194143 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001598 ! BRCA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004187 name: BRCA2_human def: "Breast cancer type 2 susceptibility protein gene" [UniProtKB:P51587] synonym: "FACD" EXACT [UniProtKB:P51587] synonym: "FANCD1" EXACT [UniProtKB:P51587] xref: EMBL:AY436640 xref: EMBL:U43746 xref: EMBL:X95152 xref: EMBL:X95153 xref: EMBL:X95154 xref: EMBL:X95155 xref: EMBL:X95156 xref: EMBL:X95157 xref: EMBL:X95158 xref: EMBL:X95159 xref: EMBL:X95160 xref: EMBL:X95161 xref: EMBL:X95162 xref: EMBL:X95163 xref: EMBL:X95164 xref: EMBL:X95165 xref: EMBL:X95166 xref: EMBL:X95167 xref: EMBL:X95168 xref: EMBL:X95169 xref: EMBL:X95170 xref: EMBL:X95171 xref: EMBL:X95172 xref: EMBL:X95173 xref: EMBL:X95174 xref: EMBL:X95175 xref: EMBL:X95176 xref: EMBL:X95177 xref: EMBL:Z73359 xref: EMBL:Z74739 xref: HGNC:HGNC:1101 xref: UniGene:Hs.34012 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001649 ! BRCA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004188 name: BRD4_human def: "Bromodomain-containing protein 4 gene" [UniProtKB:O60885] synonym: "HUNK1" EXACT [UniProtKB:O60885] xref: EMBL:AC004798 xref: EMBL:AF386649 xref: EMBL:AY166680 xref: EMBL:Y12059 xref: HGNC:HGNC:13575 xref: UniGene:Hs.187763 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006311 ! BRD4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004189 name: BRD7_human def: "Bromodomain-containing protein 7 gene" [UniProtKB:Q9NPI1] synonym: "BP75" EXACT [UniProtKB:Q9NPI1] synonym: "CELTIX1" EXACT [UniProtKB:Q9NPI1] xref: EMBL:AF152604 xref: EMBL:AF213969 xref: EMBL:AJ271881 xref: EMBL:AK027308 xref: EMBL:AK074613 xref: EMBL:BC001611 xref: EMBL:BC050728 xref: EMBL:BC094706 xref: HGNC:HGNC:14310 xref: UniGene:Hs.437894 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005400 ! BRD7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004190 name: BRE_human def: "Protein BRE gene" [UniProtKB:Q9NXR7] xref: EMBL:AF015767 xref: EMBL:AF420605 xref: EMBL:AK000097 xref: EMBL:AY438031 xref: EMBL:BC001251 xref: EMBL:L38616 xref: HGNC:HGNC:1106 xref: UniGene:Hs.11916 xref: UniGene:Hs.258314 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005951 ! BRE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004191 name: BRMS1_human def: "Breast cancer metastasis-suppressor 1 gene" [UniProtKB:Q9HCU9] xref: EMBL:AF159141 xref: EMBL:AF281036 xref: EMBL:BC009834 xref: HGNC:HGNC:17262 xref: UniGene:Hs.100426 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002147 ! BRMS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004192 name: BRSK1_human def: "BR serine/threonine-protein kinase 1 gene" [UniProtKB:Q8TDC3] synonym: "KIAA1811" EXACT [UniProtKB:Q8TDC3] synonym: "SAD1" EXACT [UniProtKB:Q8TDC3] xref: EMBL:AB058714 xref: EMBL:AF479826 xref: EMBL:AF479827 xref: EMBL:AL831945 xref: EMBL:AL834275 xref: EMBL:AY458602 xref: EMBL:AY505124 xref: EMBL:BC016681 xref: HGNC:HGNC:18994 xref: UniGene:Hs.182081 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001992 ! BRSK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004193 name: BTBD2_human def: "BTB/POZ domain-containing protein 2 gene" [UniProtKB:Q9BX70] xref: EMBL:AC004678 xref: EMBL:AC005306 xref: EMBL:AF355797 xref: EMBL:AK000393 xref: EMBL:AK027481 xref: EMBL:AL360275 xref: EMBL:BC000564 xref: EMBL:BC008035 xref: EMBL:BC053986 xref: EMBL:BC094820 xref: EMBL:CR457230 xref: HGNC:HGNC:15504 xref: UniGene:Hs.465543 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005933 ! BTBD2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004196 name: BTG3_human def: "Protein BTG3 gene" [UniProtKB:Q14201] synonym: "ANA" EXACT [UniProtKB:Q14201] synonym: "TOB5" EXACT [UniProtKB:Q14201] xref: EMBL:BC011957 xref: EMBL:D64110 xref: HGNC:HGNC:1132 xref: UniGene:Hs.473420 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001778 ! BTG3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004197 name: BTG4_human def: "Protein BTG4 gene" [UniProtKB:Q9NY30] synonym: "PC3B" EXACT [UniProtKB:Q9NY30] xref: EMBL:AJ271351 xref: HGNC:HGNC:13862 xref: UniGene:Hs.128180 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002174 ! BTG4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004198 name: BUB1B_human def: "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta gene" [UniProtKB:O60566] synonym: "BUBR1" EXACT [UniProtKB:O60566] synonym: "MAD3L" EXACT [UniProtKB:O60566] xref: EMBL:AF035933 xref: EMBL:AF046079 xref: EMBL:AF046918 xref: EMBL:AF053306 xref: EMBL:AF068760 xref: EMBL:AF107297 xref: EMBL:AF310192 xref: EMBL:AF310193 xref: EMBL:AF310194 xref: EMBL:AF310195 xref: EMBL:AF310196 xref: EMBL:AF310197 xref: EMBL:AF310198 xref: EMBL:AF310199 xref: EMBL:AF310200 xref: EMBL:AF310201 xref: EMBL:AF310202 xref: EMBL:AF310203 xref: EMBL:AF310204 xref: EMBL:AF310205 xref: EMBL:AF310206 xref: EMBL:AF310207 xref: EMBL:AF310208 xref: EMBL:AF310209 xref: EMBL:AF310210 xref: EMBL:AF310211 xref: EMBL:AF310212 xref: EMBL:AF310213 xref: EMBL:AF310214 xref: HGNC:HGNC:1149 xref: UniGene:Hs.631699 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001411 ! BUB1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004199 name: BUB1_human def: "Mitotic checkpoint serine/threonine-protein kinase BUB1 gene" [UniProtKB:O43683] synonym: "BUB1L" EXACT [UniProtKB:O43683] xref: EMBL:AF011387 xref: EMBL:AF043294 xref: EMBL:AF046078 xref: EMBL:AF047471 xref: EMBL:AF053305 xref: EMBL:AF139349 xref: EMBL:AF139350 xref: EMBL:AF139351 xref: EMBL:AF139352 xref: EMBL:AF139353 xref: EMBL:AF139354 xref: EMBL:AF139355 xref: EMBL:AF139356 xref: EMBL:AF139357 xref: EMBL:AF139358 xref: EMBL:AF139359 xref: EMBL:AF139360 xref: EMBL:AF139361 xref: EMBL:AF139362 xref: EMBL:AF139363 xref: EMBL:BC028201 xref: HGNC:HGNC:1148 xref: UniGene:Hs.469649 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001395 ! BUB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004200 name: BUB3_human def: "Mitotic checkpoint protein BUB3 gene" [UniProtKB:O43684] xref: EMBL:AF047472 xref: EMBL:AF047473 xref: EMBL:AF053304 xref: EMBL:AF081496 xref: EMBL:BC005138 xref: EMBL:BC022438 xref: HGNC:HGNC:1151 xref: UniGene:Hs.418533 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001396 ! BUB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004201 name: C1orf123_human def: "Uncharacterized protein C1orf123 gene" [UniProtKB:Q9NWV4] xref: EMBL:AK000587 xref: EMBL:AL606760 xref: EMBL:BC010908 xref: EMBL:CR457246 xref: HGNC:HGNC:26059 xref: UniGene:Hs.525391 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006314 ! CA123_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004202 name: CAB39_human def: "Calcium-binding protein 39 gene" [UniProtKB:Q9Y376] synonym: "CGI-66" EXACT [UniProtKB:Q9Y376] synonym: "MO25" EXACT [UniProtKB:Q9Y376] xref: EMBL:AF113536 xref: EMBL:AF151824 xref: EMBL:BC020570 xref: HGNC:HGNC:20292 xref: UniGene:Hs.632536 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005876 ! CAB39_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004203 name: CABLES1_human def: "CDK5 and ABL1 enzyme substrate 1 gene" [UniProtKB:Q8TDN4] synonym: "CABLES" EXACT [UniProtKB:Q8TDN4] xref: EMBL:AC011731 xref: EMBL:AC105247 xref: EMBL:AF348525 xref: EMBL:AK093243 xref: EMBL:BC004124 xref: EMBL:BC037218 xref: HGNC:HGNC:25097 xref: UniGene:Hs.11108 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001994 ! CABL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004204 name: CABLES2_human def: "CDK5 and ABL1 enzyme substrate 2 gene" [UniProtKB:Q9BTV7] synonym: "C20orf150" EXACT [UniProtKB:Q9BTV7] xref: EMBL:AL121832 xref: EMBL:BC003122 xref: HGNC:HGNC:16143 xref: UniGene:Hs.301040 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002097 ! CABL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004205 name: CACNA1A_human def: "Voltage-dependent P/Q-type calcium channel subunit alpha-1A gene" [UniProtKB:O00555] synonym: "CACH4" EXACT [UniProtKB:O00555] synonym: "CACN3" EXACT [UniProtKB:O00555] synonym: "CACNL1A4" EXACT [UniProtKB:O00555] xref: EMBL:AC005305 xref: EMBL:AC008540 xref: EMBL:AC011446 xref: EMBL:AC022436 xref: EMBL:AC026805 xref: EMBL:AC098781 xref: EMBL:AC124224 xref: EMBL:AF004883 xref: EMBL:AF004884 xref: EMBL:S76537 xref: EMBL:U06702 xref: EMBL:U79663 xref: EMBL:U79664 xref: EMBL:U79665 xref: EMBL:U79666 xref: EMBL:U79667 xref: EMBL:U79668 xref: EMBL:X99897 xref: EMBL:Z80114 xref: EMBL:Z80115 xref: HGNC:HGNC:1388 xref: UniGene:Hs.501632 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006044 ! CAC1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004210 name: CADM1_human def: "Cell adhesion molecule 1 precursor gene" [UniProtKB:Q9BY67] synonym: "IGSF4" EXACT [UniProtKB:Q9BY67] synonym: "NECL2" EXACT [UniProtKB:Q9BY67] synonym: "SYNCAM" EXACT [UniProtKB:Q9BY67] synonym: "TSLC1" EXACT [UniProtKB:Q9BY67] xref: EMBL:AB094146 xref: EMBL:AF132811 xref: EMBL:AK075502 xref: HGNC:HGNC:5951 xref: UniGene:Hs.370510 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002110 ! CADM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004211 name: CADM4_human def: "Cell adhesion molecule 4 precursor gene" [UniProtKB:Q8NFZ8] synonym: "IGSF4C" EXACT [UniProtKB:Q8NFZ8] synonym: "NECL4" EXACT [UniProtKB:Q8NFZ8] synonym: "TSLL2" EXACT [UniProtKB:Q8NFZ8] xref: EMBL:AC005525 xref: EMBL:AF363368 xref: HGNC:HGNC:30825 xref: UniGene:Hs.370984 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001983 ! CADM4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004212 name: CHAF1A_human def: "Chromatin assembly factor 1 subunit A gene" [UniProtKB:Q13111] synonym: "CAF" EXACT [UniProtKB:Q13111] synonym: "CAF1P150" EXACT [UniProtKB:Q13111] xref: EMBL:AF190465 xref: EMBL:BC052620 xref: EMBL:U20979 xref: HGNC:HGNC:1910 xref: UniGene:Hs.79018 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001742 ! CAF1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004213 name: CHAF1B_human def: "Chromatin assembly factor 1 subunit B gene" [UniProtKB:Q13112] synonym: "CAF1A" EXACT [UniProtKB:Q13112] synonym: "CAF1P60" EXACT [UniProtKB:Q13112] synonym: "MPHOSPH7" EXACT [UniProtKB:Q13112] synonym: "MPP7" EXACT [UniProtKB:Q13112] xref: EMBL:AP000694 xref: EMBL:AP001725 xref: EMBL:BC021218 xref: EMBL:U20980 xref: EMBL:X98262 xref: HGNC:HGNC:1911 xref: UniGene:Hs.75238 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001743 ! CAF1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004214 name: CALM1_human def: "Calmodulin gene" [UniProtKB:P62158] synonym: "CALM" EXACT [UniProtKB:P62158] synonym: "CAM" EXACT [UniProtKB:P62158] synonym: "CAM1" EXACT [UniProtKB:P62158] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001690 ! CALM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004215 name: CALM2_human def: "Calmodulin gene" [UniProtKB:P62158] synonym: "CAM2" EXACT [UniProtKB:P62158] synonym: "CAMB" EXACT [UniProtKB:P62158] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001690 ! CALM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004216 name: CALM3_human def: "Calmodulin gene" [UniProtKB:P62158] synonym: "CALML2" EXACT [UniProtKB:P62158] synonym: "CAM3" EXACT [UniProtKB:P62158] synonym: "CAMC" EXACT [UniProtKB:P62158] synonym: "CAMIII" EXACT [UniProtKB:P62158] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001690 ! CALM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004218 name: CAND1_human def: "Cullin-associated NEDD8-dissociated protein 1 gene" [UniProtKB:Q86VP6] synonym: "KIAA0829" EXACT [UniProtKB:Q86VP6] synonym: "TIP120" EXACT [UniProtKB:Q86VP6] synonym: "TIP120A" EXACT [UniProtKB:Q86VP6] xref: EMBL:AB020636 xref: EMBL:AF157326 xref: EMBL:AK027404 xref: EMBL:AK027783 xref: EMBL:AL133560 xref: EMBL:AL136810 xref: EMBL:AL833880 xref: EMBL:BC004232 xref: EMBL:BC026220 xref: EMBL:BC050341 xref: HGNC:HGNC:30688 xref: UniGene:Hs.546407 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005355 ! CAND1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004220 name: CASC5_human def: "Protein CASC5 gene" [UniProtKB:Q8NG31] synonym: "KIAA1570" EXACT [UniProtKB:Q8NG31] xref: EMBL:AB022190 xref: EMBL:AB046790 xref: EMBL:AF173994 xref: EMBL:AF248041 xref: EMBL:AF461041 xref: HGNC:HGNC:24054 xref: UniGene:Hs.181855 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006064 ! CASC5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004221 name: NEDD9_human def: "Enhancer of filamentation 1 gene" [UniProtKB:Q14511] synonym: "CASL" EXACT [UniProtKB:Q14511] xref: EMBL:BC040207 xref: EMBL:L43821 xref: EMBL:U64317 xref: HGNC:HGNC:7733 xref: UniGene:Hs.699288 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001782 ! CASL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004222 name: CASP9_human def: "Caspase-9 precursor gene" [UniProtKB:P55211] synonym: "MCH6" EXACT [UniProtKB:P55211] xref: EMBL:AB015653 xref: EMBL:AB019205 xref: EMBL:AB020979 xref: EMBL:AF093130 xref: EMBL:AF110376 xref: EMBL:AL512883 xref: EMBL:AY214168 xref: EMBL:BC002452 xref: EMBL:BC006463 xref: EMBL:U56390 xref: EMBL:U60521 xref: HGNC:HGNC:1511 xref: UniGene:Hs.329502 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005903 ! CASP9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004223 name: CTSB_human def: "Cathepsin B precursor gene" [UniProtKB:P07858] synonym: "CPSB" EXACT [UniProtKB:P07858] xref: EMBL:BC010240 xref: EMBL:BC095408 xref: EMBL:L16510 xref: EMBL:M13230 xref: EMBL:M14221 xref: HGNC:HGNC:2527 xref: UniGene:Hs.520898 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006345 ! CATB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004224 name: CAV1_human def: "Caveolin-1 gene" [UniProtKB:Q03135] synonym: "CAV" EXACT [UniProtKB:Q03135] xref: EMBL:AF095591 xref: EMBL:AF095592 xref: EMBL:AF095593 xref: EMBL:AF125348 xref: EMBL:AJ133269 xref: EMBL:BC009685 xref: EMBL:BC082246 xref: EMBL:BT007143 xref: EMBL:Z18951 xref: HGNC:HGNC:1527 xref: UniGene:Hs.74034 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005456 ! CAV1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004225 name: CAV2_human def: "Caveolin-2 gene" [UniProtKB:P51636] xref: EMBL:AF035752 xref: EMBL:AJ133269 xref: EMBL:AJ242718 xref: EMBL:BC005256 xref: EMBL:BT007051 xref: HGNC:HGNC:1528 xref: UniGene:Hs.212332 xref: UniGene:Hs.603096 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005462 ! CAV2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004226 name: CAPZA2_human def: "F-actin-capping protein subunit alpha-2 gene" [UniProtKB:P47755] xref: EMBL:AC002543 xref: EMBL:BC005338 xref: EMBL:BT006735 xref: EMBL:U03269 xref: EMBL:U03851 xref: HGNC:HGNC:1490 xref: UniGene:Hs.695918 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005582 ! CAZA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004227 name: CBLB_human def: "E3 ubiquitin-protein ligase CBL-B gene" [UniProtKB:Q13191] synonym: "Nbla00127" EXACT [UniProtKB:Q13191] synonym: "RNF56" EXACT [UniProtKB:Q13191] xref: EMBL:AB075490 xref: EMBL:BC032851 xref: EMBL:BX537484 xref: EMBL:U26710 xref: EMBL:U26711 xref: EMBL:U26712 xref: HGNC:HGNC:1542 xref: UniGene:Hs.430589 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005819 ! CBLB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004228 name: CBL_human def: "E3 ubiquitin-protein ligase CBL gene" [UniProtKB:P22681] synonym: "CBL2" EXACT [UniProtKB:P22681] synonym: "RNF55" EXACT [UniProtKB:P22681] xref: EMBL:X57110 xref: HGNC:HGNC:1541 xref: UniGene:Hs.504096 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005611 ! CBL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004229 name: CPE_human def: "Carboxypeptidase E precursor gene" [UniProtKB:P16870] xref: EMBL:AB006898 xref: EMBL:BC033866 xref: EMBL:BC053612 xref: EMBL:X51405 xref: HGNC:HGNC:2303 xref: UniGene:Hs.699184 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006081 ! CBPE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004230 name: CREBBP_human def: "CREB-binding protein gene" [UniProtKB:Q92793] synonym: "CBP" EXACT [UniProtKB:Q92793] xref: EMBL:U47741 xref: EMBL:U85962 xref: EMBL:U89354 xref: EMBL:U89355 xref: HGNC:HGNC:2348 xref: UniGene:Hs.459759 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005339 ! CBP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004231 name: CBX1_human def: "Chromobox protein homolog 1 gene" [UniProtKB:P83916] synonym: "CBX" EXACT [UniProtKB:P83916] xref: EMBL:BC002609 xref: EMBL:BC021302 xref: EMBL:U35451 xref: HGNC:HGNC:1551 xref: UniGene:Hs.77254 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006126 ! CBX1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004232 name: CBX5_human def: "Chromobox protein homolog 5 gene" [UniProtKB:P45973] synonym: "HP1A" EXACT [UniProtKB:P45973] xref: EMBL:BC006821 xref: EMBL:L07515 xref: EMBL:S62077 xref: EMBL:U26311 xref: HGNC:HGNC:1555 xref: UniGene:Hs.632724 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005317 ! CBX5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004234 name: CDC14A_human def: "Dual specificity protein phosphatase CDC14A gene" [UniProtKB:Q9UNH5] xref: EMBL:AF000367 xref: EMBL:AF064102 xref: EMBL:AF064103 xref: EMBL:AF122013 xref: EMBL:AY623111 xref: EMBL:BC038979 xref: HGNC:HGNC:1718 xref: UniGene:Hs.127411 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002233 ! CC14A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004235 name: CDC45L_human def: "CDC45-related protein gene" [UniProtKB:O75419] synonym: "CDC45L2" EXACT [UniProtKB:O75419] synonym: "UNQ374/PRO710" EXACT [UniProtKB:O75419] xref: EMBL:AF053074 xref: EMBL:AF062495 xref: EMBL:AF081535 xref: EMBL:AJ223728 xref: EMBL:AY358971 xref: EMBL:AY572790 xref: EMBL:BC006232 xref: EMBL:BC010022 xref: EMBL:BT006792 xref: HGNC:HGNC:1739 xref: UniGene:Hs.474217 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001426 ! CC45L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004236 name: CCAR1_human def: "Cell division cycle and apoptosis regulator protein 1 gene" [UniProtKB:Q8IX12] synonym: "CARP1" EXACT [UniProtKB:Q8IX12] synonym: "DIS" EXACT [UniProtKB:Q8IX12] xref: EMBL:AF465616 xref: EMBL:AK000741 xref: EMBL:AK001452 xref: EMBL:AK001701 xref: EMBL:AK023438 xref: EMBL:AL391539 xref: EMBL:AL513534 xref: EMBL:AY249140 xref: EMBL:BC026036 xref: EMBL:BC108682 xref: HGNC:HGNC:24236 xref: UniGene:Hs.49853 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001950 ! CCAR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004237 name: CCDC16_human def: "Coiled-coil domain-containing protein 16 gene" [UniProtKB:Q96NB3] xref: EMBL:AK055707 xref: EMBL:BC002913 xref: EMBL:BC009044 xref: EMBL:BC011584 xref: HGNC:HGNC:28291 xref: UniGene:Hs.413678 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002051 ! CCD16_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004238 name: CCDC95_human def: "Coiled-coil domain-containing protein 95 gene" [UniProtKB:Q8NBZ0] xref: EMBL:AK075133 xref: EMBL:BC047712 xref: HGNC:HGNC:26905 xref: UniGene:Hs.434864 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006053 ! CCD95_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004239 name: CCDC99_human def: "Coiled-coil domain-containing protein 99 gene" [UniProtKB:Q96EA4] xref: EMBL:AF269167 xref: EMBL:AK000371 xref: EMBL:AK074227 xref: EMBL:AY517557 xref: EMBL:BC012568 xref: HGNC:HGNC:26010 xref: UniGene:Hs.368710 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006191 ! CCD99_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004240 name: CCDC5_human def: "Coiled-coil domain-containing protein 5 gene" [UniProtKB:Q96CS2] synonym: "HEIC" EXACT [UniProtKB:Q96CS2] xref: EMBL:AK097403 xref: EMBL:AY360137 xref: EMBL:BC005958 xref: EMBL:BC014003 xref: HGNC:HGNC:25174 xref: UniGene:Hs.436617 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002034 ! CCDC5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004241 name: CCL18_human def: "C-C motif chemokine 18 precursor gene" [UniProtKB:P55774] synonym: "AMAC1" EXACT [UniProtKB:P55774] synonym: "DCCK1" EXACT [UniProtKB:P55774] synonym: "MIP4" EXACT [UniProtKB:P55774] synonym: "PARC" EXACT [UniProtKB:P55774] synonym: "SCYA18" EXACT [UniProtKB:P55774] xref: EMBL:AB000221 xref: EMBL:AB012113 xref: EMBL:AF082212 xref: EMBL:AF082213 xref: EMBL:AF082214 xref: EMBL:AF111198 xref: EMBL:BC069700 xref: EMBL:BC096124 xref: EMBL:BC096125 xref: EMBL:BC096126 xref: EMBL:BC096127 xref: EMBL:CR407660 xref: EMBL:Y13710 xref: HGNC:HGNC:10616 xref: UniGene:Hs.143961 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006087 ! CCL18_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004242 name: CCNA1_human def: "Cyclin-A1 gene" [UniProtKB:P78396] xref: EMBL:BC036346 xref: EMBL:CH471075 xref: EMBL:U66838 xref: EMBL:U97680 xref: HGNC:HGNC:1577 xref: UniGene:Hs.417050 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001701 ! CCNA1_HUMAN relationship: codes_for CCO:B0021356 ! Q8IY91_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004243 name: CCNA2_human def: "Cyclin-A2 gene" [UniProtKB:P20248] synonym: "CCN1" EXACT [UniProtKB:P20248] synonym: "CCNA" EXACT [UniProtKB:P20248] xref: EMBL:AC079341 xref: EMBL:AF518006 xref: EMBL:BC104783 xref: EMBL:BC104787 xref: EMBL:CR407692 xref: EMBL:X51688 xref: EMBL:X68303 xref: HGNC:HGNC:1578 xref: UniGene:Hs.58974 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001538 ! CCNA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004244 name: CCNB1_human def: "G2/mitotic-specific cyclin-B1 gene" [UniProtKB:P14635] synonym: "CCNB" EXACT [UniProtKB:P14635] xref: EMBL:AY338491 xref: EMBL:BC006510 xref: EMBL:M25753 xref: HGNC:HGNC:1579 xref: UniGene:Hs.23960 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001519 ! CCNB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004245 name: CCNB2_human def: "G2/mitotic-specific cyclin-B2 gene" [UniProtKB:O95067] xref: EMBL:AB020981 xref: EMBL:AF002822 xref: EMBL:AL080146 xref: EMBL:AY864066 xref: EMBL:BC105086 xref: EMBL:BC105112 xref: EMBL:CR533527 xref: HGNC:HGNC:1580 xref: UniGene:Hs.194698 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001446 ! CCNB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004246 name: CCNB3_human def: "G2/mitotic-specific cyclin-B3 gene" [UniProtKB:Q8WWL7] synonym: "CYCB3" EXACT [UniProtKB:Q8WWL7] xref: EMBL:AJ314764 xref: EMBL:AJ314765 xref: EMBL:AJ314766 xref: EMBL:AJ416458 xref: EMBL:AL137550 xref: HGNC:HGNC:18709 xref: UniGene:Hs.130310 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002007 ! CCNB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004248 name: CCND1_human def: "G1/S-specific cyclin-D1 gene" [UniProtKB:P24385] synonym: "BCL1" EXACT [UniProtKB:P24385] synonym: "PRAD1" EXACT [UniProtKB:P24385] xref: EMBL:AF511593 xref: EMBL:BC000076 xref: EMBL:BC001501 xref: EMBL:BC014078 xref: EMBL:BC023620 xref: EMBL:BC025302 xref: EMBL:BT019845 xref: EMBL:L09054 xref: EMBL:M64349 xref: EMBL:M73554 xref: EMBL:M74092 xref: EMBL:X59798 xref: EMBL:Z23022 xref: HGNC:HGNC:1582 xref: UniGene:Hs.523852 xref: UniGene:Hs.702537 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001551 ! CCND1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004249 name: CCND2_human def: "G1/S-specific cyclin-D2 gene" [UniProtKB:P30279] xref: EMBL:AF518005 xref: EMBL:BC010958 xref: EMBL:BC089384 xref: EMBL:BT019847 xref: EMBL:D13639 xref: EMBL:M88080 xref: EMBL:M88081 xref: EMBL:M88082 xref: EMBL:M88083 xref: EMBL:M90813 xref: EMBL:X68452 xref: HGNC:HGNC:1583 xref: UniGene:Hs.376071 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001573 ! CCND2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004250 name: CCND3_human def: "G1/S-specific cyclin-D3 gene" [UniProtKB:P30281] xref: EMBL:AF517525 xref: EMBL:AL160163 xref: EMBL:BC011616 xref: EMBL:M88084 xref: EMBL:M88085 xref: EMBL:M88086 xref: EMBL:M88087 xref: EMBL:M90814 xref: EMBL:M92287 xref: HGNC:HGNC:1585 xref: UniGene:Hs.534307 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001574 ! CCND3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004251 name: CCNE1_human def: "G1/S-specific cyclin-E1 gene" [UniProtKB:P24864] synonym: "CCNE" EXACT [UniProtKB:P24864] xref: EMBL:AF518727 xref: EMBL:BC035498 xref: EMBL:M73812 xref: EMBL:M74093 xref: EMBL:U40787 xref: EMBL:U40788 xref: EMBL:X95406 xref: HGNC:HGNC:1589 xref: UniGene:Hs.244723 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001554 ! CCNE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004252 name: CCNE2_human def: "G1/S-specific cyclin-E2 gene" [UniProtKB:O96020] xref: EMBL:AF091433 xref: EMBL:AF102778 xref: EMBL:AF106690 xref: EMBL:AF112857 xref: EMBL:AY850195 xref: EMBL:BC007015 xref: EMBL:BC020729 xref: EMBL:CH471060 xref: HGNC:HGNC:1590 xref: UniGene:Hs.567387 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001460 ! CCNE2_HUMAN relationship: codes_for CCO:B0001935 ! Q7Z774_HUMAN relationship: codes_for CCO:B0002001 ! Q8WUE3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004253 name: CCNF_human def: "G2/mitotic-specific cyclin-F gene" [UniProtKB:P41002] xref: EMBL:BC012349 xref: EMBL:U17105 xref: EMBL:Z36714 xref: HGNC:HGNC:1591 xref: UniGene:Hs.1973 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001602 ! CCNF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004254 name: CCNG1_human def: "Cyclin-G1 gene" [UniProtKB:P51959] synonym: "CCNG" EXACT [UniProtKB:P51959] synonym: "CYCG1" EXACT [UniProtKB:P51959] xref: EMBL:AY791292 xref: EMBL:BC000196 xref: EMBL:BC007093 xref: EMBL:BT007134 xref: EMBL:D78341 xref: EMBL:D86077 xref: EMBL:L49504 xref: EMBL:U47413 xref: EMBL:U53328 xref: EMBL:X77794 xref: HGNC:HGNC:1592 xref: UniGene:Hs.79101 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001656 ! CCNG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004255 name: CCNG2_human def: "Cyclin-G2 gene" [UniProtKB:Q16589] xref: EMBL:AF549495 xref: EMBL:BT019503 xref: EMBL:L49506 xref: EMBL:U47414 xref: HGNC:HGNC:1593 xref: UniGene:Hs.13291 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001821 ! CCNG2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004256 name: CCNH_human def: "Cyclin-H gene" [UniProtKB:P51946] xref: EMBL:AF477979 xref: EMBL:BC005280 xref: EMBL:BC016705 xref: EMBL:BC016823 xref: EMBL:BC022351 xref: EMBL:U11791 xref: EMBL:U12685 xref: HGNC:HGNC:1594 xref: UniGene:Hs.292524 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001652 ! CCNH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004260 name: CCNK_human def: "Cyclin-K gene" [UniProtKB:O75909] synonym: "CPR4" EXACT [UniProtKB:O75909] xref: EMBL:AF060515 xref: EMBL:AF270825 xref: EMBL:AF270826 xref: EMBL:AF270827 xref: EMBL:AF270828 xref: EMBL:AF270829 xref: EMBL:AF270830 xref: EMBL:AF270831 xref: EMBL:AF270832 xref: EMBL:AF542236 xref: EMBL:BC015935 xref: EMBL:BT006950 xref: HGNC:HGNC:1596 xref: UniGene:Hs.705475 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001439 ! CCNK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004262 name: CCNT1_human def: "Cyclin-T1 gene" [UniProtKB:O60563] xref: EMBL:AF045161 xref: EMBL:AF048730 xref: HGNC:HGNC:1599 xref: UniGene:Hs.279906 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001410 ! CCNT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004263 name: CCNT2_human def: "Cyclin-T2 gene" [UniProtKB:O60583] xref: EMBL:AC016725 xref: EMBL:AF048731 xref: EMBL:AF048732 xref: EMBL:AY865621 xref: HGNC:HGNC:1600 xref: UniGene:Hs.591241 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001412 ! CCNT2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004265 name: CCPG1_human def: "Cell cycle progression protein 1 gene" [UniProtKB:Q9ULG6] synonym: "CCP8" EXACT [UniProtKB:Q9ULG6] synonym: "CPR8" EXACT [UniProtKB:Q9ULG6] synonym: "KIAA1254" EXACT [UniProtKB:Q9ULG6] xref: EMBL:AB033080 xref: EMBL:AF011794 xref: EMBL:AF212228 xref: EMBL:AK022459 xref: EMBL:BC015203 xref: EMBL:BC029398 xref: EMBL:BC034914 xref: EMBL:BC039871 xref: EMBL:CH471082 xref: HGNC:HGNC:24227 xref: UniGene:Hs.612814 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002225 ! CCPG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004266 name: CCRK_human def: "Cell cycle-related kinase gene" [UniProtKB:Q8IZL9] synonym: "CDCH" EXACT [UniProtKB:Q8IZL9] xref: EMBL:AF547664 xref: EMBL:AL353572 xref: EMBL:AY904367 xref: EMBL:BC002655 xref: HGNC:HGNC:21420 xref: UniGene:Hs.522274 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001955 ! CCRK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004268 name: CDC123_human def: "Cell division cycle protein 123 homolog gene" [UniProtKB:O75794] synonym: "C10orf7" EXACT [UniProtKB:O75794] synonym: "D123" EXACT [UniProtKB:O75794] xref: EMBL:AL512770 xref: EMBL:BC001600 xref: EMBL:BC009598 xref: EMBL:CR456966 xref: EMBL:D14878 xref: EMBL:U27112 xref: HGNC:HGNC:16827 xref: UniGene:Hs.412842 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001435 ! CD123_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004269 name: ALCAM_human def: "CD166 antigen precursor gene" [UniProtKB:Q13740] synonym: "MEMD" EXACT [UniProtKB:Q13740] xref: EMBL:DQ486139 xref: EMBL:DQ486140 xref: EMBL:L38608 xref: EMBL:Y10183 xref: HGNC:HGNC:400 xref: UniGene:Hs.591293 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005455 ! CD166_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004270 name: CD28_human def: "T-cell-specific surface glycoprotein CD28 precursor gene" [UniProtKB:P10747] xref: EMBL:AC125238 xref: EMBL:AF222341 xref: EMBL:AF222342 xref: EMBL:AF222343 xref: EMBL:AF411057 xref: EMBL:AJ295273 xref: EMBL:AJ517504 xref: EMBL:BC093698 xref: EMBL:BC112085 xref: EMBL:CH471063 xref: EMBL:EF064755 xref: EMBL:J02988 xref: EMBL:M37812 xref: EMBL:M37813 xref: EMBL:M37814 xref: EMBL:M37815 xref: HGNC:HGNC:1653 xref: UniGene:Hs.591629 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001508 ! CD28_HUMAN relationship: codes_for CCO:B0001927 ! Q70WG0_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004271 name: CDKN2A_human def: "Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 gene" [UniProtKB:P42771] synonym: "CDKN2" EXACT [UniProtKB:P42771] synonym: "MTS1" EXACT [UniProtKB:P42771] xref: EMBL:AB060808 xref: EMBL:AF115544 xref: EMBL:AF527803 xref: EMBL:AL449423 xref: EMBL:BC015960 xref: EMBL:BC021998 xref: EMBL:BT007020 xref: EMBL:L27211 xref: EMBL:S69804 xref: EMBL:S69822 xref: EMBL:S69824 xref: EMBL:S78535 xref: EMBL:U12818 xref: EMBL:U12819 xref: EMBL:U12820 xref: EMBL:U26727 xref: EMBL:U38945 xref: EMBL:X94154 xref: HGNC:HGNC:1787 xref: UniGene:Hs.512599 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001615 ! CD2A1_HUMAN relationship: codes_for CCO:B0001966 ! CD2A2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004272 name: CD2AP_human def: "CD2-associated protein gene" [UniProtKB:Q9Y5K6] xref: EMBL:AF146277 xref: EMBL:AF164377 xref: EMBL:AL050105 xref: EMBL:BC069444 xref: HGNC:HGNC:14258 xref: UniGene:Hs.485518 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002257 ! CD2AP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004273 name: CDC2L1_human def: "PITSLRE serine/threonine-protein kinase CDC2L1 gene" [UniProtKB:P21127] synonym: "PITSLREA" EXACT [UniProtKB:P21127] synonym: "PK58" EXACT [UniProtKB:P21127] xref: EMBL:AF067512 xref: EMBL:AF067513 xref: EMBL:AF067514 xref: EMBL:AF067515 xref: EMBL:AF067516 xref: EMBL:AF067517 xref: EMBL:AF080678 xref: EMBL:AF080679 xref: EMBL:AF080680 xref: EMBL:AF080681 xref: EMBL:AF080682 xref: EMBL:AF080683 xref: EMBL:AF080685 xref: EMBL:AF080686 xref: EMBL:AF080687 xref: EMBL:AF080688 xref: EMBL:AF092429 xref: EMBL:AF092430 xref: EMBL:AF174497 xref: EMBL:BC033069 xref: EMBL:M37712 xref: EMBL:M88553 xref: EMBL:M88554 xref: EMBL:M88555 xref: EMBL:M88558 xref: EMBL:M88559 xref: EMBL:M88560 xref: EMBL:M88561 xref: EMBL:M88562 xref: EMBL:M88563 xref: EMBL:U04815 xref: EMBL:U04816 xref: EMBL:U04817 xref: EMBL:U04818 xref: EMBL:U04824 xref: HGNC:HGNC:1729 xref: UniGene:Hs.651228 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001540 ! CD2L1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004274 name: CDC2L2_human def: "PITSLRE serine/threonine-protein kinase CDC2L2 gene" [UniProtKB:Q9UQ88] synonym: "CDC2L3" EXACT [UniProtKB:Q9UQ88] synonym: "PITSLREB" EXACT [UniProtKB:Q9UQ88] xref: EMBL:AF067518 xref: EMBL:AF067519 xref: EMBL:AF067520 xref: EMBL:AF067521 xref: EMBL:AF067522 xref: EMBL:AF067523 xref: EMBL:AF067524 xref: EMBL:AF067525 xref: EMBL:AF067526 xref: EMBL:AF067527 xref: EMBL:AF067528 xref: EMBL:AF067529 xref: EMBL:AF080689 xref: EMBL:AF080690 xref: EMBL:AF080691 xref: EMBL:AF080692 xref: EMBL:AF080693 xref: EMBL:AF080694 xref: EMBL:AF080695 xref: EMBL:AF080696 xref: EMBL:AF080697 xref: EMBL:AF092427 xref: EMBL:AF092428 xref: EMBL:AF105714 xref: EMBL:AL031282 xref: EMBL:U04819 xref: EMBL:U07704 xref: EMBL:U07705 xref: HGNC:HGNC:1730 xref: UniGene:Hs.651228 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002241 ! CD2L2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004275 name: CDC2L5_human def: "Cell division cycle 2-like protein kinase 5 gene" [UniProtKB:Q14004] synonym: "CDC2L" EXACT [UniProtKB:Q14004] synonym: "CHED" EXACT [UniProtKB:Q14004] synonym: "KIAA1791" EXACT [UniProtKB:Q14004] xref: EMBL:AB058694 xref: EMBL:AC006023 xref: EMBL:AC072061 xref: EMBL:AJ297709 xref: EMBL:AJ297710 xref: EMBL:AY679523 xref: EMBL:M80629 xref: HGNC:HGNC:1733 xref: UniGene:Hs.233552 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001771 ! CD2L5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004277 name: PTPRC_human def: "Leukocyte common antigen precursor gene" [UniProtKB:P08575] synonym: "CD45" EXACT [UniProtKB:P08575] xref: EMBL:M23466 xref: EMBL:M23467 xref: EMBL:M23468 xref: EMBL:M23469 xref: EMBL:M23470 xref: EMBL:M23471 xref: EMBL:M23472 xref: EMBL:M23473 xref: EMBL:M23474 xref: EMBL:M23475 xref: EMBL:M23476 xref: EMBL:M23477 xref: EMBL:M23478 xref: EMBL:M23479 xref: EMBL:M23480 xref: EMBL:M23481 xref: EMBL:M23482 xref: EMBL:M23483 xref: EMBL:M23484 xref: EMBL:M23485 xref: EMBL:M23486 xref: EMBL:M23487 xref: EMBL:M23488 xref: EMBL:M23489 xref: EMBL:M23490 xref: EMBL:M23491 xref: EMBL:M23492 xref: EMBL:M23496 xref: EMBL:Y00062 xref: EMBL:Y00638 xref: HGNC:HGNC:9666 xref: UniGene:Hs.654514 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001499 ! CD45_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004278 name: CD4_human def: "T-cell surface glycoprotein CD4 precursor gene" [UniProtKB:P01730] xref: EMBL:BC025782 xref: EMBL:BT019791 xref: EMBL:BT019811 xref: EMBL:DQ012936 xref: EMBL:M12807 xref: EMBL:M35160 xref: EMBL:U47924 xref: HGNC:HGNC:1678 xref: UniGene:Hs.631659 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005740 ! CD4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004279 name: CD59_human def: "CD59 glycoprotein precursor gene" [UniProtKB:P13987] synonym: "MIC11" EXACT [UniProtKB:P13987] synonym: "MIN1" EXACT [UniProtKB:P13987] synonym: "MIN2" EXACT [UniProtKB:P13987] synonym: "MIN3" EXACT [UniProtKB:P13987] synonym: "MSK21" EXACT [UniProtKB:P13987] xref: EMBL:BC001506 xref: EMBL:BT007104 xref: EMBL:M27909 xref: EMBL:M34671 xref: EMBL:M84345 xref: EMBL:M84346 xref: EMBL:M84348 xref: EMBL:M84349 xref: EMBL:M95708 xref: EMBL:X16447 xref: EMBL:X17198 xref: EMBL:Z14113 xref: EMBL:Z14114 xref: EMBL:Z14115 xref: HGNC:HGNC:1689 xref: UniGene:Hs.278573 xref: UniGene:Hs.703109 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005875 ! CD59_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004280 name: CDK5R1_human def: "Cyclin-dependent kinase 5 activator 1 precursor gene" [UniProtKB:Q15078] synonym: "CDK5R" EXACT [UniProtKB:Q15078] synonym: "NCK5A" EXACT [UniProtKB:Q15078] xref: EMBL:AY376350 xref: EMBL:BC020580 xref: EMBL:X80343 xref: HGNC:HGNC:1775 xref: UniGene:Hs.500015 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001802 ! CD5R1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004281 name: CDK5R2_human def: "Cyclin-dependent kinase 5 activator 2 precursor gene" [UniProtKB:Q13319] synonym: "NCK5AI" EXACT [UniProtKB:Q13319] xref: EMBL:AC097468 xref: EMBL:DQ307839 xref: EMBL:U34051 xref: HGNC:HGNC:1776 xref: UniGene:Hs.158460 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001751 ! CD5R2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004283 name: CDC16_human def: "Cell division cycle protein 16 homolog gene" [UniProtKB:Q13042] synonym: "ANAPC6" EXACT [UniProtKB:Q13042] xref: EMBL:AF164598 xref: EMBL:AY599074 xref: EMBL:BC017244 xref: EMBL:U18291 xref: HGNC:HGNC:1720 xref: UniGene:Hs.374127 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001739 ! CDC16_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004284 name: CDC20_human def: "Cell division cycle protein 20 homolog gene" [UniProtKB:Q12834] xref: EMBL:AF099644 xref: EMBL:AL139289 xref: EMBL:BC000624 xref: EMBL:BC001088 xref: EMBL:BC006272 xref: EMBL:BC009425 xref: EMBL:BC009426 xref: EMBL:BC010044 xref: EMBL:BC012803 xref: EMBL:BC012827 xref: EMBL:BC013303 xref: EMBL:BC015998 xref: EMBL:BC024257 xref: EMBL:BC031294 xref: EMBL:BC110321 xref: EMBL:BT007388 xref: EMBL:DQ473545 xref: EMBL:U05340 xref: HGNC:HGNC:1723 xref: UniGene:Hs.524947 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001733 ! CDC20_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004285 name: CDC23_human def: "Cell division cycle protein 23 homolog gene" [UniProtKB:Q9UJX2] synonym: "ANAPC8" EXACT [UniProtKB:Q9UJX2] xref: EMBL:AB011472 xref: EMBL:AF053977 xref: EMBL:AF191341 xref: EMBL:AY603103 xref: EMBL:BC005258 xref: EMBL:BC010944 xref: EMBL:BC017713 xref: EMBL:BT009810 xref: HGNC:HGNC:1724 xref: UniGene:Hs.153546 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002212 ! CDC23_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004286 name: CDC26_human def: "Anaphase-promoting complex subunit CDC26 gene" [UniProtKB:Q8NHZ8] synonym: "C9orf17" EXACT [UniProtKB:Q8NHZ8] xref: EMBL:AF503918 xref: EMBL:AL449305 xref: EMBL:BC042534 xref: EMBL:BC066300 xref: HGNC:HGNC:17839 xref: UniGene:Hs.530284 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001986 ! CDC26_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004287 name: CDC27_human def: "Cell division cycle protein 27 homolog gene" [UniProtKB:P30260] synonym: "D0S1430E" EXACT [UniProtKB:P30260] synonym: "D17S978E" EXACT [UniProtKB:P30260] xref: EMBL:AY518321 xref: EMBL:BC011656 xref: EMBL:S78234 xref: EMBL:U00001 xref: HGNC:HGNC:1728 xref: UniGene:Hs.463295 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001572 ! CDC27_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004288 name: CDC2_human def: "Cell division control protein 2 homolog gene" [UniProtKB:P06493] xref: EMBL:AF512554 xref: EMBL:BC014563 xref: EMBL:BT007004 xref: EMBL:D88357 xref: EMBL:X05360 xref: EMBL:Y00272 xref: HGNC:HGNC:1722 xref: UniGene:Hs.334562 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001493 ! CDC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004289 name: CDC37_human def: "Hsp90 co-chaperone Cdc37 gene" [UniProtKB:Q16543] synonym: "CDC37A" EXACT [UniProtKB:Q16543] xref: EMBL:AY864824 xref: EMBL:BC000083 xref: EMBL:BC008793 xref: EMBL:U43077 xref: EMBL:U63131 xref: HGNC:HGNC:1735 xref: UniGene:Hs.160958 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001819 ! CDC37_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004290 name: CDC42_human def: "Cell division control protein 42 homolog precursor gene" [UniProtKB:P60953] xref: EMBL:AF498962 xref: EMBL:AF498963 xref: EMBL:AL031281 xref: EMBL:AL121734 xref: EMBL:AL121735 xref: EMBL:AY673602 xref: EMBL:BC002711 xref: EMBL:BC003682 xref: EMBL:BC018266 xref: EMBL:M35543 xref: EMBL:M57298 xref: HGNC:HGNC:1736 xref: UniGene:Hs.690198 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005338 ! CDC42_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004291 name: CDC5L_human def: "Cell division cycle 5-like protein gene" [UniProtKB:Q99459] synonym: "KIAA0432" EXACT [UniProtKB:Q99459] synonym: "PCDC5RP" EXACT [UniProtKB:Q99459] xref: EMBL:AB007892 xref: EMBL:AL133262 xref: EMBL:AL353588 xref: EMBL:AY518540 xref: EMBL:BC001568 xref: EMBL:D85423 xref: EMBL:U86753 xref: HGNC:HGNC:1743 xref: UniGene:Hs.485471 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002065 ! CDC5L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004292 name: CDC6_human def: "Cell division control protein 6 homolog gene" [UniProtKB:Q99741] synonym: "CDC18L" EXACT [UniProtKB:Q99741] xref: EMBL:AF022109 xref: EMBL:AY150310 xref: EMBL:BC025232 xref: EMBL:U77949 xref: HGNC:HGNC:1744 xref: UniGene:Hs.405958 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002087 ! CDC6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004293 name: CDC73_human def: "Parafibromin gene" [UniProtKB:Q6P1J9] synonym: "C1orf28" EXACT [UniProtKB:Q6P1J9] synonym: "HRPT2" EXACT [UniProtKB:Q6P1J9] xref: EMBL:AF312865 xref: EMBL:AK026969 xref: EMBL:AL139133 xref: EMBL:AL390863 xref: EMBL:BC007325 xref: EMBL:BC014351 xref: EMBL:BC065037 xref: EMBL:CH471067 xref: HGNC:HGNC:16783 xref: UniGene:Hs.576497 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001911 ! CDC73_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004294 name: CDC7_human def: "Cell division cycle 7-related protein kinase gene" [UniProtKB:O00311] synonym: "CDC7L1" EXACT [UniProtKB:O00311] xref: EMBL:AB003698 xref: EMBL:AF005209 xref: EMBL:AF015592 xref: EMBL:AL355871 xref: EMBL:AY585721 xref: EMBL:BC110526 xref: EMBL:BC110527 xref: EMBL:BC111044 xref: HGNC:HGNC:1745 xref: UniGene:Hs.533573 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001346 ! CDC7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004295 name: CDCA2_human def: "Cell division cycle-associated protein 2 gene" [UniProtKB:Q69YH5] xref: EMBL:AK098670 xref: EMBL:AL833396 xref: EMBL:AL833627 xref: EMBL:BC036214 xref: EMBL:BC063651 xref: EMBL:BC085609 xref: EMBL:BC104450 xref: EMBL:BC104451 xref: EMBL:BG354575 xref: HGNC:HGNC:14623 xref: UniGene:Hs.33366 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001905 ! CDCA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004296 name: CDCA3_human def: "Cell division cycle-associated protein 3 gene" [UniProtKB:Q99618] synonym: "C8" EXACT [UniProtKB:Q99618] synonym: "GRCC8" EXACT [UniProtKB:Q99618] synonym: "TOME1" EXACT [UniProtKB:Q99618] xref: EMBL:BC002551 xref: EMBL:BC036512 xref: EMBL:BG354576 xref: EMBL:U47924 xref: HGNC:HGNC:14624 xref: UniGene:Hs.524216 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002076 ! CDCA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004297 name: CDCA5_human def: "Sororin gene" [UniProtKB:Q96FF9] xref: EMBL:BC011000 xref: EMBL:BG354578 xref: HGNC:HGNC:14626 xref: UniGene:Hs.434886 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002038 ! CDCA5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004298 name: CDK10_human def: "Cell division protein kinase 10 gene" [UniProtKB:Q15131] xref: EMBL:AJ010341 xref: EMBL:AJ010342 xref: EMBL:AJ010343 xref: EMBL:AJ010344 xref: EMBL:AM392903 xref: EMBL:AM393177 xref: EMBL:AM393204 xref: EMBL:BC017342 xref: EMBL:BC025301 xref: EMBL:L33264 xref: EMBL:X78342 xref: HGNC:HGNC:1770 xref: UniGene:Hs.699177 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001803 ! CDK10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004299 name: CDK2_human def: "Cell division protein kinase 2 gene" [UniProtKB:P24941] xref: EMBL:AF512553 xref: EMBL:BC003065 xref: EMBL:BT006821 xref: EMBL:M68520 xref: EMBL:X61622 xref: EMBL:X62071 xref: HGNC:HGNC:1771 xref: UniGene:Hs.19192 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001555 ! CDK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004300 name: CDK3_human def: "Cell division protein kinase 3 gene" [UniProtKB:Q00526] xref: EMBL:AY789470 xref: EMBL:X66357 xref: HGNC:HGNC:1772 xref: UniGene:Hs.593566 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001707 ! CDK3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004301 name: CDK4_human def: "Cell division protein kinase 4 gene" [UniProtKB:P11802] xref: EMBL:AF507942 xref: EMBL:BC003644 xref: EMBL:BC005864 xref: EMBL:BC010153 xref: EMBL:M14505 xref: EMBL:S67448 xref: EMBL:U37022 xref: EMBL:U81031 xref: EMBL:Z48970 xref: HGNC:HGNC:1773 xref: UniGene:Hs.95577 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001512 ! CDK4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004302 name: CDK5_human def: "Cell division protein kinase 5 gene" [UniProtKB:Q00535] xref: EMBL:AY049778 xref: EMBL:BC005115 xref: EMBL:BT006680 xref: EMBL:X66364 xref: HGNC:HGNC:1774 xref: UniGene:Hs.647078 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001709 ! CDK5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004303 name: CDK6_human def: "Cell division protein kinase 6 gene" [UniProtKB:Q00534] xref: EMBL:AC000065 xref: EMBL:AC004011 xref: EMBL:AC004128 xref: EMBL:AY128534 xref: EMBL:BC052264 xref: EMBL:X66365 xref: HGNC:HGNC:1777 xref: UniGene:Hs.119882 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001708 ! CDK6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004304 name: CDK7_human def: "Cell division protein kinase 7 gene" [UniProtKB:P50613] synonym: "MO15" EXACT [UniProtKB:P50613] xref: EMBL:AY130859 xref: EMBL:BC000834 xref: EMBL:BC005298 xref: EMBL:L20320 xref: EMBL:X77303 xref: EMBL:X77743 xref: EMBL:X79193 xref: EMBL:Y13120 xref: HGNC:HGNC:1778 xref: UniGene:Hs.184298 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001644 ! CDK7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004307 name: CDK2AP1_human def: "Cyclin-dependent kinase 2-associated protein 1 gene" [UniProtKB:O14519] synonym: "CDKAP1" EXACT [UniProtKB:O14519] synonym: "DOC1" EXACT [UniProtKB:O14519] xref: EMBL:AB006077 xref: EMBL:AF006484 xref: EMBL:BC034717 xref: HGNC:HGNC:14002 xref: UniGene:Hs.433201 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001355 ! CDKA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004308 name: CDKN3_human def: "Cyclin-dependent kinase inhibitor 3 gene" [UniProtKB:Q16667] synonym: "CDI1" EXACT [UniProtKB:Q16667] synonym: "CIP2" EXACT [UniProtKB:Q16667] synonym: "KAP" EXACT [UniProtKB:Q16667] xref: EMBL:AF213033 xref: EMBL:AF213036 xref: EMBL:AF213038 xref: EMBL:AF213039 xref: EMBL:AF213041 xref: EMBL:AF213042 xref: EMBL:AF213046 xref: EMBL:AF213047 xref: EMBL:AF213053 xref: EMBL:AY194117 xref: EMBL:L25876 xref: EMBL:L27711 xref: EMBL:U02681 xref: HGNC:HGNC:1791 xref: UniGene:Hs.84113 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001823 ! CDKN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004309 name: CDKN1A_human def: "Cyclin-dependent kinase inhibitor 1 gene" [UniProtKB:P38936] synonym: "CAP20" EXACT [UniProtKB:P38936] synonym: "CDKN1" EXACT [UniProtKB:P38936] synonym: "CIP1" EXACT [UniProtKB:P38936] synonym: "MDA6" EXACT [UniProtKB:P38936] synonym: "PIC1" EXACT [UniProtKB:P38936] synonym: "SDI1" EXACT [UniProtKB:P38936] synonym: "WAF1" EXACT [UniProtKB:P38936] xref: EMBL:AF497972 xref: EMBL:BC000275 xref: EMBL:BC000312 xref: EMBL:BC001935 xref: EMBL:BC013967 xref: EMBL:L25610 xref: EMBL:L26165 xref: EMBL:L47232 xref: EMBL:L47233 xref: EMBL:S67388 xref: EMBL:U03106 xref: EMBL:U09579 xref: EMBL:Z85996 xref: HGNC:HGNC:1784 xref: UniGene:Hs.370771 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001599 ! CDN1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004310 name: CDKN1B_human def: "Cyclin-dependent kinase inhibitor 1B gene" [UniProtKB:P46527] synonym: "KIP1" EXACT [UniProtKB:P46527] xref: EMBL:AF480891 xref: EMBL:BC001971 xref: EMBL:EF474465 xref: EMBL:S76986 xref: EMBL:S76988 xref: EMBL:U10906 xref: HGNC:HGNC:1785 xref: UniGene:Hs.238990 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001343 ! A7KMP4_HUMAN relationship: codes_for CCO:B0001624 ! CDN1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004311 name: CDKN1C_human def: "Cyclin-dependent kinase inhibitor 1C gene" [UniProtKB:P49918] synonym: "KIP2" EXACT [UniProtKB:P49918] xref: EMBL:AC013791 xref: EMBL:BC067842 xref: EMBL:D64137 xref: EMBL:U22398 xref: EMBL:U48869 xref: HGNC:HGNC:1786 xref: UniGene:Hs.106070 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001333 ! A6NK88_HUMAN relationship: codes_for CCO:B0001640 ! CDN1C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004312 name: CDKN2B_human def: "Cyclin-dependent kinase 4 inhibitor B gene" [UniProtKB:P42772] synonym: "MTS2" EXACT [UniProtKB:P42772] xref: EMBL:AF513858 xref: EMBL:AL449423 xref: EMBL:BC014469 xref: EMBL:CR536529 xref: EMBL:L36844 xref: EMBL:S69805 xref: EMBL:U17075 xref: HGNC:HGNC:1788 xref: UniGene:Hs.72901 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001616 ! CDN2B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004313 name: CDKN2C_human def: "Cyclin-dependent kinase 4 inhibitor C gene" [UniProtKB:P42773] synonym: "CDKN6" EXACT [UniProtKB:P42773] xref: EMBL:AF041248 xref: EMBL:AF041249 xref: EMBL:AF041250 xref: EMBL:AY094608 xref: EMBL:BC000598 xref: EMBL:BC005041 xref: EMBL:BC016173 xref: EMBL:U17074 xref: HGNC:HGNC:1789 xref: UniGene:Hs.525324 xref: UniGene:Hs.699587 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001617 ! CDN2C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004314 name: CDKN2D_human def: "Cyclin-dependent kinase 4 inhibitor D gene" [UniProtKB:P55273] xref: EMBL:AF044171 xref: EMBL:AF061327 xref: EMBL:AF518878 xref: EMBL:BC001822 xref: EMBL:CR542158 xref: EMBL:U20498 xref: EMBL:U40343 xref: EMBL:U49399 xref: HGNC:HGNC:1790 xref: UniGene:Hs.435051 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001675 ! CDN2D_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004315 name: CDT1_human def: "DNA replication factor Cdt1 gene" [UniProtKB:Q9H211] xref: EMBL:AB053172 xref: EMBL:AF070552 xref: EMBL:AF321125 xref: EMBL:BC000137 xref: EMBL:BC008676 xref: EMBL:BC008860 xref: EMBL:BC009410 xref: EMBL:BC014202 xref: EMBL:BC049205 xref: HGNC:HGNC:24576 xref: UniGene:Hs.122908 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002126 ! CDT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004316 name: CEP110_human def: "Centrosomal protein of 110 kDa gene" [UniProtKB:O43303] synonym: "CP110" EXACT [UniProtKB:O43303] synonym: "KIAA0419" EXACT [UniProtKB:O43303] xref: EMBL:AB007879 xref: EMBL:AC003108 xref: EMBL:AC012621 xref: EMBL:AF083322 xref: EMBL:AF513978 xref: EMBL:AK074079 xref: EMBL:AL137068 xref: EMBL:AY651261 xref: EMBL:BC002932 xref: EMBL:BC036654 xref: EMBL:BC089415 xref: EMBL:BX640927 xref: EMBL:CR749255 xref: HGNC:HGNC:1858 xref: UniGene:Hs.279912 xref: UniGene:Hs.653263 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001389 ! CE110_HUMAN relationship: codes_for CCO:B0041260 ! CP110_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004317 name: CEBPB_human def: "CCAAT/enhancer-binding protein beta gene" [UniProtKB:P17676] synonym: "PP9092" EXACT [UniProtKB:P17676] synonym: "TCF5" EXACT [UniProtKB:P17676] xref: EMBL:AF289608 xref: EMBL:AL161937 xref: EMBL:AY193834 xref: EMBL:BC007538 xref: EMBL:BC021931 xref: EMBL:X52560 xref: HGNC:HGNC:1834 xref: UniGene:Hs.517106 xref: UniGene:Hs.688479 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005514 ! CEBPB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004318 name: CEBPG_human def: "CCAAT/enhancer-binding protein gamma gene" [UniProtKB:P53567] xref: EMBL:BC007582 xref: EMBL:BC013128 xref: EMBL:BT019819 xref: EMBL:BT019820 xref: EMBL:U20240 xref: HGNC:HGNC:1837 xref: UniGene:Hs.429666 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005324 ! CEBPG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004320 name: CELSR3_human def: "Cadherin EGF LAG seven-pass G-type receptor 3 precursor gene" [UniProtKB:Q9NYQ7] synonym: "CDHF11" EXACT [UniProtKB:Q9NYQ7] synonym: "EGFL1" EXACT [UniProtKB:Q9NYQ7] synonym: "FMI1" EXACT [UniProtKB:Q9NYQ7] synonym: "KIAA0812" EXACT [UniProtKB:Q9NYQ7] synonym: "MEGF2" EXACT [UniProtKB:Q9NYQ7] xref: EMBL:AB011536 xref: EMBL:AF231023 xref: HGNC:HGNC:3230 xref: UniGene:Hs.631926 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005546 ! CELR3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004321 name: CENTD2_human def: "Centaurin-delta-2 gene" [UniProtKB:Q96P48] synonym: "ARAP1" EXACT [UniProtKB:Q96P48] synonym: "KIAA0782" EXACT [UniProtKB:Q96P48] xref: EMBL:AB018325 xref: EMBL:AB209473 xref: EMBL:AF411983 xref: EMBL:AJ621557 xref: EMBL:AY049732 xref: EMBL:BC008315 xref: EMBL:BC021244 xref: EMBL:BC056401 xref: HGNC:HGNC:16925 xref: UniGene:Hs.503165 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002052 ! CEND2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004322 name: CENPB_human def: "Major centromere autoantigen B gene" [UniProtKB:P07199] xref: EMBL:AL109804 xref: EMBL:BC053847 xref: EMBL:X05299 xref: EMBL:X55039 xref: HGNC:HGNC:1852 xref: UniGene:Hs.516855 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005431 ! CENPB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004324 name: CENPE_human def: "Centromeric protein E gene" [UniProtKB:Q02224] xref: EMBL:AB209996 xref: EMBL:AC079919 xref: EMBL:CH471057 xref: EMBL:Z15005 xref: HGNC:HGNC:1856 xref: UniGene:Hs.75573 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001715 ! CENPE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004325 name: CENPF_human def: "Centromere protein F gene" [UniProtKB:P49454] xref: EMBL:AL445305 xref: EMBL:AL445666 xref: EMBL:U19769 xref: EMBL:U25725 xref: EMBL:U30872 xref: HGNC:HGNC:1857 xref: UniGene:Hs.497741 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001629 ! CENPF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004326 name: CENPH_human def: "Centromere protein H gene" [UniProtKB:Q9H3R5] synonym: "ICEN35" EXACT [UniProtKB:Q9H3R5] xref: EMBL:AB035124 xref: EMBL:BC012024 xref: EMBL:BC015355 xref: HGNC:HGNC:17268 xref: UniGene:Hs.631967 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005682 ! CENPH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004327 name: CENPJ_human def: "Centromere protein J gene" [UniProtKB:Q9HC77] synonym: "CPAP" EXACT [UniProtKB:Q9HC77] synonym: "LAP" EXACT [UniProtKB:Q9HC77] synonym: "LIP1" EXACT [UniProtKB:Q9HC77] xref: EMBL:AF139625 xref: EMBL:AF141337 xref: EMBL:AJ303006 xref: EMBL:AL354798 xref: EMBL:BC024209 xref: EMBL:BC113110 xref: EMBL:BC113662 xref: EMBL:BC113664 xref: HGNC:HGNC:17272 xref: UniGene:Hs.513379 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005426 ! CENPJ_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004328 name: ITGB3BP_human def: "Centromere protein R gene" [UniProtKB:Q13352] synonym: "CENPR" EXACT [UniProtKB:Q13352] synonym: "NRIF3" EXACT [UniProtKB:Q13352] xref: EMBL:AF175306 xref: EMBL:AL592218 xref: EMBL:BC009929 xref: EMBL:BC014385 xref: EMBL:BX004807 xref: EMBL:U37139 xref: HGNC:HGNC:6157 xref: UniGene:Hs.166539 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006198 ! CENPR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004329 name: CEP55_human def: "Centrosomal protein of 55 kDa gene" [UniProtKB:Q53EZ4] synonym: "C10orf3" EXACT [UniProtKB:Q53EZ4] synonym: "URCC6" EXACT [UniProtKB:Q53EZ4] xref: EMBL:AB091343 xref: EMBL:AK001402 xref: EMBL:AK223495 xref: EMBL:AL356214 xref: EMBL:AY788918 xref: EMBL:BC008947 xref: EMBL:BX640718 xref: HGNC:HGNC:1161 xref: UniGene:Hs.14559 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001837 ! CEP55_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004330 name: CEP63_human def: "Centrosomal protein of 63 kDa gene" [UniProtKB:Q96MT8] xref: EMBL:AK023448 xref: EMBL:AK023738 xref: EMBL:AK056465 xref: EMBL:BC014050 xref: EMBL:BC068997 xref: EMBL:BK005503 xref: HGNC:HGNC:25815 xref: UniGene:Hs.443301 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005590 ! CEP63_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004331 name: CEP76_human def: "Centrosomal protein of 76 kDa gene" [UniProtKB:Q8TAP6] synonym: "C18orf9" EXACT [UniProtKB:Q8TAP6] xref: EMBL:AK022604 xref: EMBL:AL833727 xref: EMBL:BC026307 xref: HGNC:HGNC:25727 xref: UniGene:Hs.236940 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005244 ! CEP76_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004332 name: CETN1_human def: "Centrin-1 gene" [UniProtKB:Q12798] synonym: "CEN1" EXACT [UniProtKB:Q12798] synonym: "CETN" EXACT [UniProtKB:Q12798] xref: EMBL:BC029515 xref: EMBL:U03270 xref: HGNC:HGNC:1866 xref: UniGene:Hs.122511 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001731 ! CETN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004333 name: CETN2_human def: "Centrin-2 gene" [UniProtKB:P41208] synonym: "CALT" EXACT [UniProtKB:P41208] synonym: "CEN2" EXACT [UniProtKB:P41208] xref: EMBL:AY919675 xref: EMBL:BC005334 xref: EMBL:BC013873 xref: EMBL:BT007256 xref: EMBL:U82671 xref: EMBL:X72964 xref: HGNC:HGNC:1867 xref: UniGene:Hs.82794 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001604 ! CETN2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004334 name: CETN3_human def: "Centrin-3 gene" [UniProtKB:O15182] synonym: "CEN3" EXACT [UniProtKB:O15182] xref: EMBL:BC005383 xref: EMBL:BC093793 xref: EMBL:BC112040 xref: EMBL:BT006688 xref: EMBL:Y12473 xref: HGNC:HGNC:1868 xref: UniGene:Hs.591767 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001368 ! CETN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004335 name: CFTR_human def: "Cystic fibrosis transmembrane conductance regulator gene" [UniProtKB:P13569] synonym: "ABCC7" EXACT [UniProtKB:P13569] xref: EMBL:AC000061 xref: EMBL:AC000111 xref: EMBL:CH236947 xref: EMBL:DQ354388 xref: EMBL:DQ354389 xref: EMBL:DQ354390 xref: EMBL:DQ354391 xref: EMBL:DQ356258 xref: EMBL:DQ356259 xref: EMBL:DQ356261 xref: EMBL:DQ356262 xref: EMBL:DQ356263 xref: EMBL:DQ356264 xref: EMBL:DQ388128 xref: EMBL:DQ388129 xref: EMBL:DQ388131 xref: EMBL:DQ388132 xref: EMBL:DQ388133 xref: EMBL:DQ388134 xref: EMBL:DQ388135 xref: EMBL:DQ388138 xref: EMBL:DQ388139 xref: EMBL:DQ388140 xref: EMBL:DQ388141 xref: EMBL:DQ388142 xref: EMBL:DQ388143 xref: EMBL:DQ388145 xref: EMBL:M28668 xref: EMBL:M55106 xref: EMBL:M55107 xref: EMBL:M55108 xref: EMBL:M55110 xref: EMBL:M55111 xref: EMBL:M55112 xref: EMBL:M55113 xref: EMBL:M55114 xref: EMBL:M55115 xref: EMBL:M55116 xref: EMBL:M55117 xref: EMBL:M55118 xref: EMBL:M55119 xref: EMBL:M55120 xref: EMBL:M55121 xref: EMBL:M55122 xref: EMBL:M55123 xref: EMBL:M55124 xref: EMBL:M55125 xref: EMBL:M55126 xref: EMBL:M55127 xref: EMBL:M55128 xref: EMBL:M55129 xref: EMBL:M55130 xref: EMBL:M55131 xref: EMBL:M65196 xref: EMBL:M65197 xref: HGNC:HGNC:1884 xref: UniGene:Hs.489786 xref: UniGene:Hs.621460 xref: UniGene:Hs.661104 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005605 ! CFTR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004336 name: C7orf20_human def: "UPF0363 protein C7orf20 gene" [UniProtKB:Q7L5D6] synonym: "CGI-20" EXACT [UniProtKB:Q7L5D6] xref: EMBL:AF132954 xref: EMBL:AL133014 xref: EMBL:BC003550 xref: HGNC:HGNC:21690 xref: UniGene:Hs.107387 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006174 ! CG020_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004337 name: C7orf25_human def: "UPF0415 protein C7orf25 gene" [UniProtKB:Q9BPX7] xref: EMBL:AK024820 xref: EMBL:BC000769 xref: EMBL:BC001845 xref: HGNC:HGNC:21703 xref: UniGene:Hs.214247 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006330 ! CG025_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004338 name: C7orf36_human def: "Uncharacterized protein C7orf36 gene" [UniProtKB:Q9NRH1] synonym: "GK003" EXACT [UniProtKB:Q9NRH1] xref: EMBL:AC011290 xref: EMBL:AF226046 xref: EMBL:BC022043 xref: EMBL:CR457198 xref: HGNC:HGNC:24857 xref: UniGene:Hs.83313 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006249 ! CG036_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004339 name: CGREF1_human def: "Cell growth regulator with EF hand domain protein 1 gene" [UniProtKB:Q99674] synonym: "CGR11" EXACT [UniProtKB:Q99674] xref: EMBL:U66468 xref: HGNC:HGNC:16962 xref: UniGene:Hs.159525 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002081 ! CGRE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004340 name: CGRRF1_human def: "Cell growth regulator with RING finger domain protein 1 gene" [UniProtKB:Q99675] synonym: "CGR19" EXACT [UniProtKB:Q99675] synonym: "RNF197" EXACT [UniProtKB:Q99675] xref: EMBL:BC015063 xref: EMBL:U66469 xref: HGNC:HGNC:15528 xref: UniGene:Hs.59106 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002082 ! CGRF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004341 name: C8orf32_human def: "Uncharacterized protein C8orf32 gene" [UniProtKB:Q96HA8] xref: EMBL:AK001066 xref: EMBL:BC008781 xref: HGNC:HGNC:25490 xref: UniGene:Hs.18029 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005179 ! CH032_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004342 name: HSPE1_human def: "10 kDa heat shock protein, mitochondrial gene" [UniProtKB:P61604] xref: EMBL:AF107893 xref: EMBL:AF107894 xref: EMBL:AJ250915 xref: EMBL:BC023518 xref: EMBL:U07550 xref: EMBL:X75821 xref: HGNC:HGNC:5269 xref: UniGene:Hs.1197 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006092 ! CH10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004343 name: HSPD1_human def: "60 kDa heat shock protein, mitochondrial precursor gene" [UniProtKB:P10809] synonym: "HSP60" EXACT [UniProtKB:P10809] xref: EMBL:AJ250915 xref: EMBL:BC002676 xref: EMBL:BC003030 xref: EMBL:BC067082 xref: EMBL:BC073746 xref: EMBL:DQ217936 xref: EMBL:M22382 xref: EMBL:M34664 xref: HGNC:HGNC:5261 xref: UniGene:Hs.595053 xref: UniGene:Hs.632539 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005730 ! CH60_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004344 name: CHD3_human def: "Chromodomain-helicase-DNA-binding protein 3 gene" [UniProtKB:Q12873] xref: EMBL:AF006515 xref: EMBL:U08379 xref: EMBL:U91543 xref: HGNC:HGNC:1918 xref: UniGene:Hs.25601 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006082 ! CHD3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004345 name: CHD8_human def: "Chromodomain-helicase-DNA-binding protein 8 gene" [UniProtKB:Q9HCK8] synonym: "HELSNF1" EXACT [UniProtKB:Q9HCK8] synonym: "KIAA1564" EXACT [UniProtKB:Q9HCK8] xref: EMBL:AB046784 xref: EMBL:AL834524 xref: EMBL:BC011695 xref: EMBL:BC025964 xref: EMBL:BC036920 xref: EMBL:CB043942 xref: EMBL:CR749315 xref: HGNC:HGNC:20153 xref: UniGene:Hs.530698 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005444 ! CHD8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004346 name: CHFR_human def: "E3 ubiquitin-protein ligase CHFR gene" [UniProtKB:Q96EP1] synonym: "RNF196" EXACT [UniProtKB:Q96EP1] xref: EMBL:AF170724 xref: EMBL:AK001658 xref: EMBL:AK027687 xref: EMBL:AL137561 xref: EMBL:BC012072 xref: HGNC:HGNC:20455 xref: UniGene:Hs.656770 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002035 ! CHFR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004347 name: CHEK1_human def: "Serine/threonine-protein kinase Chk1 gene" [UniProtKB:O14757] synonym: "CHK1" EXACT [UniProtKB:O14757] xref: EMBL:AB032387 xref: EMBL:AF016582 xref: EMBL:AF032874 xref: EMBL:AF527555 xref: EMBL:BC004202 xref: EMBL:BC017575 xref: HGNC:HGNC:1925 xref: UniGene:Hs.24529 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001359 ! CHK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004348 name: CHEK2_human def: "Serine/threonine-protein kinase Chk2 gene" [UniProtKB:O96017] synonym: "CHK2" EXACT [UniProtKB:O96017] synonym: "RAD53" EXACT [UniProtKB:O96017] xref: EMBL:AB040105 xref: EMBL:AF086904 xref: EMBL:AF096279 xref: EMBL:AF174135 xref: EMBL:AJ131197 xref: EMBL:AL117330 xref: EMBL:AL121825 xref: EMBL:AY551295 xref: EMBL:AY551296 xref: EMBL:AY551297 xref: EMBL:AY551298 xref: EMBL:AY551299 xref: EMBL:AY551300 xref: EMBL:AY551301 xref: EMBL:AY551302 xref: EMBL:AY551303 xref: EMBL:AY551304 xref: EMBL:AY551305 xref: EMBL:AY800241 xref: EMBL:BC004207 xref: EMBL:CR456418 xref: HGNC:HGNC:16627 xref: UniGene:Hs.291363 xref: UniGene:Hs.505297 xref: UniGene:Hs.632780 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001459 ! CHK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004349 name: CHMP1A_human def: "Charged multivesicular body protein 1a gene" [UniProtKB:Q9HD42] synonym: "CHMP1" EXACT [UniProtKB:Q9HD42] synonym: "KIAA0047" EXACT [UniProtKB:Q9HD42] synonym: "PCOLN3" EXACT [UniProtKB:Q9HD42] synonym: "PRSM1" EXACT [UniProtKB:Q9HD42] xref: EMBL:AF281063 xref: EMBL:BC007527 xref: EMBL:BC010000 xref: EMBL:BT006841 xref: EMBL:D38554 xref: EMBL:U58048 xref: HGNC:HGNC:8740 xref: UniGene:Hs.589427 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002148 ! CHM1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004350 name: CHMP4B_human def: "Charged multivesicular body protein 4b gene" [UniProtKB:Q9H444] synonym: "C20orf178" EXACT [UniProtKB:Q9H444] synonym: "SHAX1" EXACT [UniProtKB:Q9H444] xref: EMBL:AB100261 xref: EMBL:AL050349 xref: EMBL:AY329085 xref: EMBL:BC033859 xref: HGNC:HGNC:16171 xref: UniGene:Hs.472471 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005270 ! CHM4B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004354 name: CITED2_human def: "Cbp/p300-interacting transactivator 2 gene" [UniProtKB:Q99967] synonym: "MRG1" EXACT [UniProtKB:Q99967] xref: EMBL:AF109161 xref: EMBL:AF129290 xref: EMBL:AL592429 xref: EMBL:BC004377 xref: EMBL:U65093 xref: HGNC:HGNC:1987 xref: UniGene:Hs.82071 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002091 ! CITE2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004357 name: C10orf119_human def: "UPF0557 protein C10orf119 gene" [UniProtKB:Q9BTE3] xref: EMBL:AK023143 xref: EMBL:BC000935 xref: EMBL:BC004183 xref: EMBL:BC007219 xref: EMBL:CR457299 xref: HGNC:HGNC:25782 xref: UniGene:Hs.124246 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005262 ! CJ119_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004358 name: CDK5RAP1_human def: "CDK5 regulatory subunit-associated protein 1 gene" [UniProtKB:Q96SZ6] synonym: "C20orf34" EXACT [UniProtKB:Q96SZ6] synonym: "CGI-05" EXACT [UniProtKB:Q96SZ6] synonym: "HSPC167" EXACT [UniProtKB:Q96SZ6] xref: EMBL:AF152097 xref: EMBL:AF161516 xref: EMBL:AK023992 xref: EMBL:AK027449 xref: EMBL:AL355392 xref: EMBL:BC001215 xref: EMBL:BC050706 xref: HGNC:HGNC:15880 xref: UniGene:Hs.435952 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002062 ! CK5P1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004360 name: CDK5RAP3_human def: "CDK5 regulatory subunit-associated protein 3 gene" [UniProtKB:Q96JB5] synonym: "IC53" EXACT [UniProtKB:Q96JB5] synonym: "MSTP016" EXACT [UniProtKB:Q96JB5] synonym: "OK/SW-cl.114" EXACT [UniProtKB:Q96JB5] synonym: "PP1553" EXACT [UniProtKB:Q96JB5] xref: EMBL:AB062433 xref: EMBL:AF110322 xref: EMBL:AF217982 xref: EMBL:AF343090 xref: EMBL:AK023722 xref: EMBL:AK223387 xref: EMBL:BC009957 xref: EMBL:BC072435 xref: HGNC:HGNC:18673 xref: UniGene:Hs.20157 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002044 ! CK5P3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004361 name: CKAP2_human def: "Cytoskeleton-associated protein 2 gene" [UniProtKB:Q8WWK9] synonym: "LB1" EXACT [UniProtKB:Q8WWK9] synonym: "TMAP" EXACT [UniProtKB:Q8WWK9] xref: EMBL:AF177227 xref: EMBL:AJ429398 xref: EMBL:AK001611 xref: EMBL:AK022982 xref: EMBL:AL136848 xref: EMBL:AL359513 xref: EMBL:AY062261 xref: EMBL:AY062262 xref: EMBL:BC010901 xref: EMBL:BC105806 xref: EMBL:BC130296 xref: EMBL:EF560732 xref: EMBL:Y15758 xref: HGNC:HGNC:1990 xref: UniGene:Hs.444028 xref: UniGene:Hs.521482 xref: UniGene:Hs.653959 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002006 ! CKAP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004362 name: CKAP4_human def: "Cytoskeleton-associated protein 4 gene" [UniProtKB:Q07065] xref: EMBL:AK223563 xref: EMBL:BC082972 xref: EMBL:BC094824 xref: EMBL:X69910 xref: HGNC:HGNC:16991 xref: UniGene:Hs.74368 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005829 ! CKAP4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004363 name: CKAP5_human def: "Cytoskeleton-associated protein 5 gene" [UniProtKB:Q14008] synonym: "KIAA0097" EXACT [UniProtKB:Q14008] xref: EMBL:D43948 xref: EMBL:X92474 xref: HGNC:HGNC:28959 xref: UniGene:Hs.201253 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001772 ! CKAP5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004364 name: CKS1B_human def: "Cyclin-dependent kinases regulatory subunit 1 gene" [UniProtKB:P61024] synonym: "CKS1" EXACT [UniProtKB:P61024] synonym: "PNAS-143" EXACT [UniProtKB:P61024] synonym: "PNAS-16" EXACT [UniProtKB:P61024] xref: EMBL:AF274941 xref: EMBL:AF274943 xref: EMBL:AF279897 xref: EMBL:AL451085 xref: EMBL:BC007751 xref: EMBL:BC015629 xref: EMBL:BC070319 xref: EMBL:BC070320 xref: EMBL:BT007196 xref: EMBL:CH471121 xref: EMBL:X54941 xref: HGNC:HGNC:19083 xref: UniGene:Hs.374378 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001686 ! CKS1_HUMAN relationship: codes_for CCO:B0001867 ! Q5T179_HUMAN relationship: codes_for CCO:B0002118 ! Q9BZU3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004365 name: CKS2_human def: "Cyclin-dependent kinases regulatory subunit 2 gene" [UniProtKB:P33552] xref: EMBL:AF506708 xref: EMBL:BC006458 xref: EMBL:X54942 xref: HGNC:HGNC:2000 xref: UniGene:Hs.83758 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001586 ! CKS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004366 name: CLASP1_human def: "CLIP-associating protein 1 gene" [UniProtKB:Q7Z460] synonym: "KIAA0622" EXACT [UniProtKB:Q7Z460] synonym: "MAST1" EXACT [UniProtKB:Q7Z460] xref: EMBL:AB014522 xref: EMBL:AC012447 xref: EMBL:AC013399 xref: EMBL:AC079449 xref: EMBL:AF347693 xref: EMBL:AJ288057 xref: EMBL:BC032563 xref: EMBL:BC112940 xref: EMBL:CR933722 xref: HGNC:HGNC:17088 xref: UniGene:Hs.469840 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001933 ! CLAP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004367 name: CLASP2_human def: "CLIP-associating protein 2 gene" [UniProtKB:O75122] synonym: "KIAA0627" EXACT [UniProtKB:O75122] xref: EMBL:AB014527 xref: EMBL:AJ288058 xref: EMBL:AJ288059 xref: EMBL:AK024770 xref: EMBL:AL137636 xref: EMBL:BC029035 xref: HGNC:HGNC:17078 xref: UniGene:Hs.696092 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001422 ! CLAP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004368 name: CLTA_human def: "Clathrin light chain A gene" [UniProtKB:P09496] xref: EMBL:AL158830 xref: EMBL:BC009201 xref: EMBL:BC019287 xref: EMBL:BT007170 xref: EMBL:DQ270158 xref: EMBL:M20471 xref: EMBL:M20472 xref: HGNC:HGNC:2090 xref: UniGene:Hs.522114 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005448 ! CLCA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004369 name: CLTCL1_human def: "Clathrin heavy chain 2 gene" [UniProtKB:P53675] synonym: "CLH22" EXACT [UniProtKB:P53675] synonym: "CLTCL" EXACT [UniProtKB:P53675] synonym: "CLTD" EXACT [UniProtKB:P53675] xref: EMBL:U41763 xref: EMBL:U60802 xref: EMBL:U60803 xref: EMBL:X95486 xref: EMBL:X95487 xref: HGNC:HGNC:2093 xref: UniGene:Hs.368266 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005460 ! CLH2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004370 name: CLIP1_human def: "CAP-Gly domain-containing linker protein 1 gene" [UniProtKB:P30622] synonym: "CYLN1" EXACT [UniProtKB:P30622] synonym: "RSN" EXACT [UniProtKB:P30622] xref: EMBL:M97501 xref: EMBL:X64838 xref: HGNC:HGNC:10461 xref: UniGene:Hs.524809 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001580 ! CLIP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004372 name: CLSPN_human def: "Claspin gene" [UniProtKB:Q9HAW4] xref: EMBL:AF297866 xref: EMBL:AL354864 xref: EMBL:BC038991 xref: EMBL:BC062215 xref: HGNC:HGNC:19715 xref: UniGene:Hs.175613 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002142 ! CLSPN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004374 name: C14orf48_human def: "Uncharacterized protein C14orf48 gene" [UniProtKB:Q8NCU1] xref: EMBL:AK097741 xref: EMBL:BC021728 xref: HGNC:HGNC:19860 xref: UniGene:Hs.143845 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005286 ! CN048_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004375 name: CTNNBIP1_human def: "Beta-catenin-interacting protein 1 gene" [UniProtKB:Q9NSA3] synonym: "ICAT" EXACT [UniProtKB:Q9NSA3] xref: EMBL:AB021262 xref: EMBL:BC014300 xref: HGNC:HGNC:16913 xref: UniGene:Hs.463759 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006076 ! CNBP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004376 name: NCAPD2_human def: "Condensin complex subunit 1 gene" [UniProtKB:Q15021] synonym: "CAPD2" EXACT [UniProtKB:Q15021] synonym: "CNAP1" EXACT [UniProtKB:Q15021] synonym: "KIAA0159" EXACT [UniProtKB:Q15021] xref: EMBL:BC028182 xref: EMBL:D63880 xref: HGNC:HGNC:24305 xref: UniGene:Hs.5719 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001801 ! CND1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004377 name: NCAPH_human def: "Condensin complex subunit 2 gene" [UniProtKB:Q15003] synonym: "BRRN" EXACT [UniProtKB:Q15003] synonym: "BRRN1" EXACT [UniProtKB:Q15003] synonym: "CAPH" EXACT [UniProtKB:Q15003] synonym: "KIAA0074" EXACT [UniProtKB:Q15003] xref: EMBL:BC024211 xref: EMBL:D38553 xref: HGNC:HGNC:1112 xref: UniGene:Hs.308045 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001797 ! CND2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004378 name: NCAPG_human def: "Condensin complex subunit 3 gene" [UniProtKB:Q9BPX3] synonym: "CAPG" EXACT [UniProtKB:Q9BPX3] synonym: "NYMEL3" EXACT [UniProtKB:Q9BPX3] xref: EMBL:AB013299 xref: EMBL:AF235023 xref: EMBL:AF331796 xref: EMBL:AK022512 xref: EMBL:AK023147 xref: EMBL:AK027511 xref: EMBL:BC000827 xref: EMBL:BC002337 xref: EMBL:BC101476 xref: HGNC:HGNC:24304 xref: UniGene:Hs.446201 xref: UniGene:Hs.567567 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002092 ! CND3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004379 name: NCAPD3_human def: "Condensin-2 complex subunit D3 gene" [UniProtKB:P42695] synonym: "CAPD3" EXACT [UniProtKB:P42695] synonym: "KIAA0056" EXACT [UniProtKB:P42695] xref: EMBL:AF070553 xref: EMBL:AP001775 xref: EMBL:BC098398 xref: EMBL:CH471065 xref: EMBL:D29954 xref: HGNC:HGNC:28952 xref: UniGene:Hs.438550 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001614 ! CNDD3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004380 name: NCAPG2_human def: "Condensin-2 complex subunit G2 gene" [UniProtKB:Q86XI2] synonym: "LUZP5" EXACT [UniProtKB:Q86XI2] xref: EMBL:AK022744 xref: EMBL:AK023347 xref: EMBL:BC005878 xref: EMBL:BC020560 xref: EMBL:BC043404 xref: EMBL:BX537845 xref: HGNC:HGNC:21904 xref: UniGene:Hs.18616 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001943 ! CNDG2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004382 name: CNTROB_human def: "Centrobin gene" [UniProtKB:Q8N137] synonym: "LIP8" EXACT [UniProtKB:Q8N137] synonym: "PP1221" EXACT [UniProtKB:Q8N137] xref: EMBL:AF141344 xref: EMBL:AF331638 xref: EMBL:AK074847 xref: EMBL:AL137669 xref: EMBL:AL833907 xref: EMBL:AY160226 xref: EMBL:AY160227 xref: EMBL:BC014055 xref: EMBL:BC021134 xref: HGNC:HGNC:29616 xref: UniGene:Hs.348012 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001961 ! CNTRB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004383 name: ACACA_human def: "Acetyl-CoA carboxylase 1 gene" [UniProtKB:Q13085] synonym: "ACAC" EXACT [UniProtKB:Q13085] synonym: "ACC1" EXACT [UniProtKB:Q13085] synonym: "ACCA" EXACT [UniProtKB:Q13085] xref: EMBL:AJ534888 xref: EMBL:AJ534889 xref: EMBL:AJ564444 xref: EMBL:AY237919 xref: EMBL:AY315619 xref: EMBL:AY315620 xref: EMBL:AY315621 xref: EMBL:AY315623 xref: EMBL:AY315625 xref: EMBL:AY315627 xref: EMBL:U19822 xref: HGNC:HGNC:84 xref: UniGene:Hs.160556 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0035952 ! ACACA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004384 name: EBF1_human def: "Transcription factor COE1 gene" [UniProtKB:Q9UH73] synonym: "COE1" EXACT [UniProtKB:Q9UH73] synonym: "EBF" EXACT [UniProtKB:Q9UH73] xref: EMBL:AF208502 xref: EMBL:BC038805 xref: EMBL:BC041178 xref: HGNC:HGNC:3126 xref: UniGene:Hs.657753 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006030 ! COE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004386 name: COX17_human def: "Cytochrome c oxidase copper chaperone gene" [UniProtKB:Q14061] xref: EMBL:AF269243 xref: EMBL:AF269244 xref: EMBL:BC010933 xref: EMBL:BC105280 xref: EMBL:BC108317 xref: EMBL:L77701 xref: HGNC:HGNC:2264 xref: UniGene:Hs.534383 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006089 ! COX17_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004388 name: C16orf24_human def: "Uncharacterized protein C16orf24 gene" [UniProtKB:Q9BQD7] synonym: "RJD7" EXACT [UniProtKB:Q9BQD7] xref: EMBL:AE006464 xref: EMBL:BC001181 xref: EMBL:BC002624 xref: HGNC:HGNC:14152 xref: UniGene:Hs.166244 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006205 ! CP024_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004389 name: CEP250_human def: "Centrosome-associated protein CEP250 gene" [UniProtKB:Q9BV73] synonym: "CEP2" EXACT [UniProtKB:Q9BV73] synonym: "CNAP1" EXACT [UniProtKB:Q9BV73] xref: EMBL:AF022655 xref: EMBL:AF049105 xref: EMBL:AL121586 xref: EMBL:BC001433 xref: HGNC:HGNC:1859 xref: UniGene:Hs.443976 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002099 ! CP250_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004391 name: CAPNS1_human def: "Calpain small subunit 1 gene" [UniProtKB:P04632] synonym: "CAPN4" EXACT [UniProtKB:P04632] synonym: "CAPNS" EXACT [UniProtKB:P04632] xref: EMBL:AC002984 xref: EMBL:AD001527 xref: EMBL:AY789642 xref: EMBL:BC000592 xref: EMBL:BC007779 xref: EMBL:BC011903 xref: EMBL:BC017308 xref: EMBL:BC018931 xref: EMBL:BC021933 xref: EMBL:BC023643 xref: EMBL:BC064998 xref: EMBL:BT009775 xref: EMBL:M31502 xref: EMBL:M31503 xref: EMBL:M31504 xref: EMBL:M31505 xref: EMBL:M31506 xref: EMBL:M31507 xref: EMBL:M31508 xref: EMBL:M31509 xref: EMBL:M31510 xref: EMBL:M31511 xref: EMBL:X04106 xref: HGNC:HGNC:1481 xref: UniGene:Hs.515371 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006088 ! CPNS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004392 name: C18orf25_human def: "Uncharacterized protein C18orf25 gene" [UniProtKB:Q96B23] xref: EMBL:AL713661 xref: EMBL:AL832027 xref: EMBL:BC016149 xref: EMBL:BC084579 xref: EMBL:BX640683 xref: HGNC:HGNC:28172 xref: UniGene:Hs.116486 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005186 ! CR025_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004393 name: CRADD_human def: "Death domain-containing protein CRADD gene" [UniProtKB:P78560] synonym: "RAIDD" EXACT [UniProtKB:P78560] xref: EMBL:BC017042 xref: EMBL:U79115 xref: EMBL:U84388 xref: HGNC:HGNC:2340 xref: UniGene:Hs.38533 xref: UniGene:Hs.591016 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006182 ! CRADD_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004394 name: MCC_human def: "Colorectal mutant cancer protein gene" [UniProtKB:P23508] xref: EMBL:BC009279 xref: EMBL:BC018919 xref: EMBL:M62397 xref: HGNC:HGNC:6935 xref: UniGene:Hs.593171 xref: UniGene:Hs.649603 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001549 ! CRCM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004395 name: CREB1_human def: "cAMP response element-binding protein gene" [UniProtKB:P16220] xref: EMBL:BC010636 xref: EMBL:M27691 xref: EMBL:M34356 xref: EMBL:S53724 xref: EMBL:S72459 xref: EMBL:X55545 xref: EMBL:X60003 xref: HGNC:HGNC:2345 xref: UniGene:Hs.584750 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005681 ! CREB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004396 name: CREB3_human def: "Cyclic AMP-responsive element-binding protein 3 gene" [UniProtKB:O43889] synonym: "LZIP" EXACT [UniProtKB:O43889] xref: EMBL:AF009368 xref: EMBL:AF029674 xref: EMBL:AF211847 xref: EMBL:AF211848 xref: EMBL:BC009402 xref: EMBL:BC010158 xref: EMBL:U59629 xref: EMBL:U88528 xref: HGNC:HGNC:2347 xref: UniGene:Hs.522110 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005498 ! CREB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004398 name: CRNKL1_human def: "Crooked neck-like protein 1 gene" [UniProtKB:Q9BZJ0] synonym: "CGI-201" EXACT [UniProtKB:Q9BZJ0] synonym: "CRN" EXACT [UniProtKB:Q9BZJ0] synonym: "MSTP021" EXACT [UniProtKB:Q9BZJ0] xref: EMBL:AF111802 xref: EMBL:AF255443 xref: EMBL:AF318302 xref: EMBL:AF318303 xref: EMBL:AF318304 xref: EMBL:AF318305 xref: EMBL:AK022908 xref: EMBL:AK023246 xref: EMBL:AK023728 xref: EMBL:AL035454 xref: HGNC:HGNC:15762 xref: UniGene:Hs.171342 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005593 ! CRNL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004399 name: CROCC_human def: "Rootletin gene" [UniProtKB:Q5TZA2] synonym: "KIAA0445" EXACT [UniProtKB:Q5TZA2] xref: EMBL:AB007914 xref: EMBL:AF527734 xref: EMBL:AL049569 xref: EMBL:BK005505 xref: EMBL:BX284668 xref: EMBL:DQ139275 xref: HGNC:HGNC:21299 xref: UniGene:Hs.309403 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001895 ! CROCC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004400 name: C19orf25_human def: "UPF0449 protein C19orf25 gene" [UniProtKB:Q9UFG5] xref: EMBL:AK093985 xref: EMBL:AL122089 xref: EMBL:BC018441 xref: HGNC:HGNC:26711 xref: UniGene:Hs.532840 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006066 ! CS025_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004402 name: CSNK2A1_human def: "Casein kinase II subunit alpha gene" [UniProtKB:P68400] synonym: "CK2A1" EXACT [UniProtKB:P68400] xref: EMBL:AL049761 xref: EMBL:BC011668 xref: EMBL:BC053532 xref: EMBL:BC071167 xref: EMBL:J02853 xref: EMBL:M55265 xref: EMBL:X70251 xref: HGNC:HGNC:2457 xref: UniGene:Hs.654675 xref: UniGene:Hs.701971 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005428 ! CSK21_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004406 name: CSMD1_human def: "CUB and sushi domain-containing protein 1 precursor gene" [UniProtKB:Q96PZ7] synonym: "KIAA1890" EXACT [UniProtKB:Q96PZ7] synonym: "UNQ5952/PRO19863" EXACT [UniProtKB:Q96PZ7] xref: EMBL:AB067477 xref: EMBL:AF333704 xref: EMBL:AK126936 xref: EMBL:AY017307 xref: EMBL:AY358174 xref: HGNC:HGNC:14026 xref: UniGene:Hs.571466 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006004 ! CSMD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004407 name: GPS1_human def: "COP9 signalosome complex subunit 1 gene" [UniProtKB:Q13098] synonym: "COPS1" EXACT [UniProtKB:Q13098] synonym: "CSN1" EXACT [UniProtKB:Q13098] xref: EMBL:AK093283 xref: EMBL:BC000155 xref: EMBL:BC064503 xref: EMBL:BT009834 xref: EMBL:U20285 xref: HGNC:HGNC:4549 xref: UniGene:Hs.268530 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001740 ! CSN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004408 name: COPS5_human def: "COP9 signalosome complex subunit 5 gene" [UniProtKB:Q92905] synonym: "CSN5" EXACT [UniProtKB:Q92905] synonym: "JAB1" EXACT [UniProtKB:Q92905] xref: EMBL:AY078082 xref: EMBL:BC001187 xref: EMBL:BC001859 xref: EMBL:BC007272 xref: EMBL:BX648542 xref: EMBL:CR541678 xref: EMBL:U65928 xref: EMBL:U70734 xref: HGNC:HGNC:2240 xref: UniGene:Hs.491912 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002025 ! CSN5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004409 name: COPS6_human def: "COP9 signalosome complex subunit 6 gene" [UniProtKB:Q7L5N1] synonym: "CSN6" EXACT [UniProtKB:Q7L5N1] synonym: "HVIP" EXACT [UniProtKB:Q7L5N1] xref: EMBL:BC002520 xref: EMBL:U70735 xref: HGNC:HGNC:21749 xref: UniGene:Hs.15591 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006133 ! CSN6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004411 name: C20orf12_human def: "Ankyrin repeat-containing protein C20orf12 gene" [UniProtKB:Q9NVP4] synonym: "C20orf84" EXACT [UniProtKB:Q9NVP4] xref: EMBL:AK001462 xref: EMBL:AK055544 xref: EMBL:AK131451 xref: EMBL:AL049646 xref: EMBL:AL121893 xref: EMBL:CR749327 xref: EMBL:DQ104738 xref: HGNC:HGNC:15858 xref: UniGene:Hs.472225 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005952 ! CT012_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004413 name: C20orf195_human def: "Uncharacterized protein C20orf195 gene" [UniProtKB:Q9BVV2] xref: EMBL:AL121829 xref: EMBL:BC000912 xref: HGNC:HGNC:28764 xref: UniGene:Hs.197755 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005208 ! CT195_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004414 name: CTCF_human def: "Transcriptional repressor CTCF gene" [UniProtKB:P49711] xref: EMBL:AF145468 xref: EMBL:AF145469 xref: EMBL:AF145470 xref: EMBL:AF145471 xref: EMBL:AF145472 xref: EMBL:AF145473 xref: EMBL:AF145474 xref: EMBL:AF145475 xref: EMBL:AF145476 xref: EMBL:AF145477 xref: EMBL:BC014267 xref: EMBL:U25435 xref: HGNC:HGNC:13723 xref: UniGene:Hs.368367 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001630 ! CTCF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004415 name: CTDSP1_human def: "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 gene" [UniProtKB:Q9GZU7] synonym: "NIF3" EXACT [UniProtKB:Q9GZU7] synonym: "NLIIF" EXACT [UniProtKB:Q9GZU7] synonym: "SCP1" EXACT [UniProtKB:Q9GZU7] xref: EMBL:AF229162 xref: EMBL:AF229163 xref: EMBL:BC012977 xref: HGNC:HGNC:21614 xref: UniGene:Hs.444468 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005302 ! CTDS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004416 name: CTNNA1_human def: "Catenin alpha-1 gene" [UniProtKB:P35221] xref: EMBL:AF102787 xref: EMBL:AF102788 xref: EMBL:AF102789 xref: EMBL:AF102790 xref: EMBL:AF102791 xref: EMBL:AF102792 xref: EMBL:AF102793 xref: EMBL:AF102794 xref: EMBL:AF102795 xref: EMBL:AF102796 xref: EMBL:AF102797 xref: EMBL:AF102798 xref: EMBL:AF102799 xref: EMBL:AF102800 xref: EMBL:AF102801 xref: EMBL:AF102802 xref: EMBL:AF102803 xref: EMBL:AY884207 xref: EMBL:BC000385 xref: EMBL:D13866 xref: EMBL:D14705 xref: EMBL:L22080 xref: EMBL:L23805 xref: EMBL:U03100 xref: HGNC:HGNC:2509 xref: UniGene:Hs.534797 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005824 ! CTNA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004417 name: CTNNB1_human def: "Catenin beta-1 gene" [UniProtKB:P35222] synonym: "CTNNB" EXACT [UniProtKB:P35222] synonym: "OK/SW-cl.35" EXACT [UniProtKB:P35222] synonym: "PRO2286" EXACT [UniProtKB:P35222] xref: EMBL:AB062292 xref: EMBL:AF130085 xref: EMBL:AY081165 xref: EMBL:AY463360 xref: EMBL:BC058926 xref: EMBL:X87838 xref: EMBL:Z19054 xref: HGNC:HGNC:2514 xref: UniGene:Hs.476018 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005327 ! CTNB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004418 name: CTNND1_human def: "Catenin delta-1 gene" [UniProtKB:O60716] synonym: "KIAA0384" EXACT [UniProtKB:O60716] xref: EMBL:AB002382 xref: EMBL:AF062317 xref: EMBL:AF062318 xref: EMBL:AF062319 xref: EMBL:AF062320 xref: EMBL:AF062321 xref: EMBL:AF062322 xref: EMBL:AF062323 xref: EMBL:AF062324 xref: EMBL:AF062325 xref: EMBL:AF062326 xref: EMBL:AF062327 xref: EMBL:AF062328 xref: EMBL:AF062329 xref: EMBL:AF062330 xref: EMBL:AF062331 xref: EMBL:AF062332 xref: EMBL:AF062333 xref: EMBL:AF062334 xref: EMBL:AF062335 xref: EMBL:AF062336 xref: EMBL:AF062337 xref: EMBL:AF062338 xref: EMBL:AF062339 xref: EMBL:AF062340 xref: EMBL:AF062341 xref: EMBL:AF062342 xref: EMBL:AF062343 xref: EMBL:AF062344 xref: EMBL:AK292554 xref: EMBL:AY505564 xref: EMBL:BC075795 xref: HGNC:HGNC:2515 xref: UniGene:Hs.166011 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005839 ! CTND1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004419 name: CTNNAL1_human def: "Alpha-catulin gene" [UniProtKB:Q9UBT7] xref: EMBL:AF006070 xref: EMBL:AF030233 xref: EMBL:AF080071 xref: EMBL:AF134871 xref: EMBL:AF134872 xref: EMBL:AF134873 xref: EMBL:AF134874 xref: EMBL:AF134875 xref: EMBL:AF134876 xref: EMBL:AF134877 xref: EMBL:AF134878 xref: EMBL:AF134879 xref: EMBL:AF134880 xref: EMBL:AF134881 xref: EMBL:AF134882 xref: EMBL:AF134883 xref: EMBL:AF134884 xref: EMBL:AF134885 xref: EMBL:AF134886 xref: EMBL:AF134887 xref: EMBL:AF134888 xref: EMBL:AF135021 xref: EMBL:AK223230 xref: EMBL:AL050016 xref: EMBL:AL354797 xref: EMBL:AY523969 xref: EMBL:BC117208 xref: EMBL:BC117234 xref: EMBL:U97067 xref: HGNC:HGNC:2512 xref: UniGene:Hs.58488 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005881 ! CTNL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004420 name: CIT_human def: "Citron Rho-interacting kinase gene" [UniProtKB:O14578] synonym: "KIAA0949" EXACT [UniProtKB:O14578] synonym: "STK21" EXACT [UniProtKB:O14578] xref: EMBL:AB023166 xref: EMBL:AC002563 xref: EMBL:AC004813 xref: EMBL:AC079317 xref: EMBL:AY209000 xref: EMBL:AY257469 xref: HGNC:HGNC:1985 xref: UniGene:Hs.119594 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001356 ! CTRO_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004421 name: CUL1_human def: "Cullin-1 gene" [UniProtKB:Q13616] xref: EMBL:AC005229 xref: EMBL:AF062536 xref: EMBL:BC125119 xref: EMBL:BC125120 xref: EMBL:BX537409 xref: EMBL:U58087 xref: HGNC:HGNC:2551 xref: UniGene:Hs.146806 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001759 ! CUL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004422 name: CUL2_human def: "Cullin-2 gene" [UniProtKB:Q13617] xref: EMBL:AF126404 xref: EMBL:AL392046 xref: EMBL:BC009591 xref: EMBL:BC110901 xref: EMBL:U58088 xref: EMBL:U83410 xref: HGNC:HGNC:2552 xref: UniGene:Hs.82919 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001760 ! CUL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004423 name: CUL3_human def: "Cullin-3 gene" [UniProtKB:Q13618] synonym: "KIAA0617" EXACT [UniProtKB:Q13618] xref: EMBL:AB014517 xref: EMBL:AF052147 xref: EMBL:AF062537 xref: EMBL:AF064087 xref: EMBL:AY337761 xref: EMBL:BC031844 xref: EMBL:BC039598 xref: EMBL:BC092409 xref: EMBL:U58089 xref: HGNC:HGNC:2553 xref: UniGene:Hs.372286 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001761 ! CUL3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004424 name: CUL4A_human def: "Cullin-4A gene" [UniProtKB:Q13619] xref: EMBL:AB012193 xref: EMBL:AB178950 xref: EMBL:AF077188 xref: EMBL:AL136221 xref: EMBL:AY365124 xref: EMBL:BC008308 xref: EMBL:U58090 xref: HGNC:HGNC:2554 xref: UniGene:Hs.339735 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001762 ! CUL4A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004425 name: CUL4B_human def: "Cullin-4B gene" [UniProtKB:Q13620] synonym: "KIAA0695" EXACT [UniProtKB:Q13620] xref: EMBL:AB014595 xref: EMBL:AC002476 xref: EMBL:AF212995 xref: EMBL:AY365125 xref: EMBL:BC036216 xref: EMBL:BX537787 xref: EMBL:U58091 xref: HGNC:HGNC:2555 xref: UniGene:Hs.102914 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001763 ! CUL4B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004426 name: CUL5_human def: "Cullin-5 gene" [UniProtKB:Q93034] synonym: "VACM1" EXACT [UniProtKB:Q93034] xref: EMBL:AF017061 xref: EMBL:AF327710 xref: EMBL:BC063306 xref: EMBL:X81882 xref: HGNC:HGNC:2556 xref: UniGene:Hs.440320 xref: UniGene:Hs.701122 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002027 ! CUL5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004429 name: CUZD1_human def: "CUB and zona pellucida-like domain-containing protein 1 precursor gene" [UniProtKB:Q86UP6] synonym: "UNQ224/PRO257" EXACT [UniProtKB:Q86UP6] xref: EMBL:AC073585 xref: EMBL:AF305835 xref: EMBL:AL359747 xref: EMBL:AY260047 xref: EMBL:AY260048 xref: EMBL:AY260049 xref: EMBL:AY260050 xref: EMBL:AY358556 xref: EMBL:BX538283 xref: EMBL:BX538284 xref: HGNC:HGNC:17937 xref: UniGene:Hs.647182 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001940 ! CUZD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004430 name: CYLD_human def: "Probable ubiquitin carboxyl-terminal hydrolase CYLD gene" [UniProtKB:Q9NQC7] synonym: "CYLD1" EXACT [UniProtKB:Q9NQC7] synonym: "HSPC057" EXACT [UniProtKB:Q9NQC7] synonym: "KIAA0849" EXACT [UniProtKB:Q9NQC7] xref: EMBL:AB020656 xref: EMBL:AF161542 xref: EMBL:AJ250014 xref: EMBL:BC012342 xref: HGNC:HGNC:2584 xref: UniGene:Hs.578973 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002153 ! CYLD_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004432 name: SPECC1L_human def: "Cytospin-A gene" [UniProtKB:Q69YQ0] synonym: "CYTSA" EXACT [UniProtKB:Q69YQ0] synonym: "KIAA0376" EXACT [UniProtKB:Q69YQ0] xref: EMBL:AB002374 xref: EMBL:AL832425 xref: EMBL:AY884293 xref: HGNC:HGNC:29022 xref: UniGene:Hs.474384 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001906 ! CYTSA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004433 name: DAB2IP_human def: "Disabled homolog 2-interacting protein gene" [UniProtKB:Q5VWQ8] synonym: "AF9Q34" EXACT [UniProtKB:Q5VWQ8] synonym: "AIP1" EXACT [UniProtKB:Q5VWQ8] synonym: "KIAA1743" EXACT [UniProtKB:Q5VWQ8] xref: EMBL:AB051530 xref: EMBL:AF367051 xref: EMBL:AL365274 xref: EMBL:AY032952 xref: EMBL:BC146762 xref: HGNC:HGNC:17294 xref: UniGene:Hs.522378 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001899 ! DAB2P_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004434 name: DACH1_human def: "Dachshund homolog 1 gene" [UniProtKB:Q9UI36] synonym: "DACH" EXACT [UniProtKB:Q9UI36] xref: EMBL:AF069509 xref: EMBL:AF102546 xref: EMBL:AF356492 xref: EMBL:AJ005670 xref: EMBL:AL079278 xref: EMBL:AL138698 xref: EMBL:AL139186 xref: EMBL:AL163542 xref: EMBL:AL354995 xref: EMBL:BC021219 xref: HGNC:HGNC:2663 xref: UniGene:Hs.129452 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005195 ! DACH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004435 name: DAPK1_human def: "Death-associated protein kinase 1 gene" [UniProtKB:P53355] synonym: "DAPK" EXACT [UniProtKB:P53355] xref: EMBL:BT006935 xref: EMBL:CR749834 xref: EMBL:X76104 xref: HGNC:HGNC:2674 xref: UniGene:Hs.380277 xref: UniGene:Hs.693441 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005482 ! DAPK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004437 name: DAXX_human def: "Death domain-associated protein 6 gene" [UniProtKB:Q9UER7] synonym: "BING2" EXACT [UniProtKB:Q9UER7] synonym: "DAP6" EXACT [UniProtKB:Q9UER7] xref: EMBL:AB015051 xref: EMBL:AF006041 xref: EMBL:AF015956 xref: EMBL:AF039136 xref: EMBL:AF050179 xref: EMBL:AF097742 xref: EMBL:BC000220 xref: EMBL:Z97183 xref: EMBL:Z97184 xref: HGNC:HGNC:2681 xref: UniGene:Hs.336916 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002196 ! DAXX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004438 name: DAZ1_human def: "Deleted in azoospermia protein 1 gene" [UniProtKB:Q9NQZ3] synonym: "DAZ" EXACT [UniProtKB:Q9NQZ3] xref: EMBL:AC006338 xref: EMBL:AF271087 xref: EMBL:AF271088 xref: HGNC:HGNC:2682 xref: UniGene:Hs.522868 xref: UniGene:Hs.70936 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005886 ! DAZ1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004439 name: DAZAP2_human def: "DAZ-associated protein 2 gene" [UniProtKB:Q15038] synonym: "KIAA0058" EXACT [UniProtKB:Q15038] xref: EMBL:AY430097 xref: EMBL:BC002334 xref: EMBL:BC007900 xref: EMBL:D31767 xref: HGNC:HGNC:2684 xref: UniGene:Hs.369761 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005180 ! DAZP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004440 name: DBC1_human def: "Deleted in bladder cancer protein 1 precursor gene" [UniProtKB:O60477] synonym: "DBCCR1" EXACT [UniProtKB:O60477] synonym: "FAM5A" EXACT [UniProtKB:O60477] synonym: "IB3089A" EXACT [UniProtKB:O60477] xref: EMBL:AF027734 xref: EMBL:AL138894 xref: EMBL:AL353773 xref: EMBL:BC021560 xref: EMBL:BC065196 xref: EMBL:BC071702 xref: HGNC:HGNC:2687 xref: UniGene:Hs.532316 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001409 ! DBC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004441 name: DBF4_human def: "Protein DBF4 homolog A gene" [UniProtKB:Q9UBU7] synonym: "ASK" EXACT [UniProtKB:Q9UBU7] synonym: "DBF4A" EXACT [UniProtKB:Q9UBU7] synonym: "ZDBF1" EXACT [UniProtKB:Q9UBU7] xref: EMBL:AB028069 xref: EMBL:AB028070 xref: EMBL:AC003083 xref: EMBL:AC005164 xref: EMBL:AF160249 xref: EMBL:AF160876 xref: EMBL:AK292569 xref: EMBL:BC036045 xref: EMBL:BC047693 xref: EMBL:CH236949 xref: EMBL:CH471091 xref: HGNC:HGNC:17364 xref: UniGene:Hs.485380 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002194 ! DBF4A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004442 name: DYNC1I1_human def: "Cytoplasmic dynein 1 intermediate chain 1 gene" [UniProtKB:O14576] synonym: "DNCI1" EXACT [UniProtKB:O14576] synonym: "DNCIC1" EXACT [UniProtKB:O14576] xref: EMBL:AC002452 xref: EMBL:AC002540 xref: EMBL:AC022261 xref: EMBL:AC091779 xref: EMBL:AF063228 xref: EMBL:AF123074 xref: EMBL:AK091339 xref: HGNC:HGNC:2963 xref: UniGene:Hs.440364 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005648 ! DC1I1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004443 name: DCC_human def: "Netrin receptor DCC precursor gene" [UniProtKB:P43146] xref: EMBL:M32286 xref: EMBL:M32288 xref: EMBL:M32290 xref: EMBL:M32292 xref: EMBL:M63696 xref: EMBL:M63698 xref: EMBL:M63700 xref: EMBL:M63702 xref: EMBL:M63718 xref: EMBL:X76132 xref: HGNC:HGNC:2701 xref: UniGene:Hs.579550 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001619 ! DCC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004444 name: DCP1A_human def: "mRNA-decapping enzyme 1A gene" [UniProtKB:Q9NPI6] synonym: "SMIF" EXACT [UniProtKB:Q9NPI6] xref: EMBL:AJ275986 xref: EMBL:AK001969 xref: EMBL:AY146651 xref: EMBL:BC007439 xref: HGNC:HGNC:18714 xref: UniGene:Hs.476353 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005432 ! DCP1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004445 name: DCP2_human def: "mRNA-decapping enzyme 2 gene" [UniProtKB:Q8IU60] synonym: "NUDT20" EXACT [UniProtKB:Q8IU60] xref: EMBL:AK090564 xref: EMBL:AY135173 xref: EMBL:AY146650 xref: EMBL:BC045596 xref: EMBL:BC064593 xref: HGNC:HGNC:24452 xref: UniGene:Hs.443875 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005433 ! DCP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004446 name: DCLRE1A_human def: "DNA cross-link repair 1A protein gene" [UniProtKB:Q6PJP8] synonym: "KIAA0086" EXACT [UniProtKB:Q6PJP8] synonym: "SNM1" EXACT [UniProtKB:Q6PJP8] synonym: "SNM1A" EXACT [UniProtKB:Q6PJP8] xref: EMBL:AL592546 xref: EMBL:AY607842 xref: EMBL:BC013124 xref: EMBL:BC062582 xref: EMBL:D42045 xref: HGNC:HGNC:17660 xref: UniGene:Hs.1560 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001916 ! DCR1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004447 name: DCTN1_human def: "Dynactin subunit 1 gene" [UniProtKB:Q14203] xref: EMBL:AF064203 xref: EMBL:AF064204 xref: EMBL:AF064205 xref: EMBL:AF086927 xref: EMBL:AF086928 xref: EMBL:AF086929 xref: EMBL:AF086930 xref: EMBL:AF086931 xref: EMBL:AF086932 xref: EMBL:AF086933 xref: EMBL:AF086934 xref: EMBL:AF086935 xref: EMBL:AF086936 xref: EMBL:AF086937 xref: EMBL:AF086938 xref: EMBL:AF086939 xref: EMBL:AF086940 xref: EMBL:AF086941 xref: EMBL:AF086942 xref: EMBL:AF086943 xref: EMBL:AF086944 xref: EMBL:AF086945 xref: EMBL:AF086946 xref: EMBL:AF086947 xref: EMBL:BC006163 xref: EMBL:BT006758 xref: EMBL:X98801 xref: HGNC:HGNC:2711 xref: UniGene:Hs.516111 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001779 ! DCTN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004448 name: DCTN2_human def: "Dynactin subunit 2 gene" [UniProtKB:Q13561] synonym: "DCTN50" EXACT [UniProtKB:Q13561] xref: EMBL:AY189155 xref: EMBL:BC000718 xref: EMBL:BC009468 xref: EMBL:BC014083 xref: EMBL:U50733 xref: HGNC:HGNC:2712 xref: UniGene:Hs.289123 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005177 ! DCTN2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004449 name: DCTN3_human def: "Dynactin subunit 3 gene" [UniProtKB:O75935] synonym: "DCTN22" EXACT [UniProtKB:O75935] xref: EMBL:AF082513 xref: EMBL:AL160270 xref: EMBL:AL450283 xref: EMBL:BC000319 xref: EMBL:BC003004 xref: EMBL:BC107697 xref: EMBL:CR541889 xref: HGNC:HGNC:2713 xref: UniGene:Hs.511768 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001440 ! DCTN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004450 name: DDB1_human def: "DNA damage-binding protein 1 gene" [UniProtKB:Q16531] synonym: "XAP1" EXACT [UniProtKB:Q16531] xref: EMBL:AJ002955 xref: EMBL:AP003108 xref: EMBL:AY960579 xref: EMBL:BC011686 xref: EMBL:BC050530 xref: EMBL:BC051764 xref: EMBL:CH471076 xref: EMBL:L40326 xref: EMBL:U18299 xref: EMBL:U32986 xref: HGNC:HGNC:2717 xref: UniGene:Hs.290758 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005584 ! DDB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004451 name: DDB2_human def: "DNA damage-binding protein 2 gene" [UniProtKB:Q92466] xref: EMBL:AB107037 xref: EMBL:AB107038 xref: EMBL:AB107039 xref: EMBL:AB107040 xref: EMBL:AY220533 xref: EMBL:BC000093 xref: EMBL:BT007139 xref: EMBL:U18300 xref: HGNC:HGNC:2718 xref: UniGene:Hs.702063 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005658 ! DDB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004452 name: DDIT3_human def: "DNA damage-inducible transcript 3 gene" [UniProtKB:P35638] synonym: "CHOP" EXACT [UniProtKB:P35638] synonym: "GADD153" EXACT [UniProtKB:P35638] xref: EMBL:AY880949 xref: EMBL:BC003637 xref: EMBL:S40706 xref: EMBL:S62138 xref: HGNC:HGNC:2726 xref: UniGene:Hs.505777 xref: UniGene:Hs.690217 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001594 ! DDIT3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004453 name: DDR1_human def: "Epithelial discoidin domain-containing receptor 1 precursor gene" [UniProtKB:Q08345] synonym: "CAK" EXACT [UniProtKB:Q08345] synonym: "EDDR1" EXACT [UniProtKB:Q08345] synonym: "NEP" EXACT [UniProtKB:Q08345] synonym: "NTRK4" EXACT [UniProtKB:Q08345] synonym: "PTK3A" EXACT [UniProtKB:Q08345] synonym: "RTK6" EXACT [UniProtKB:Q08345] synonym: "TRKE" EXACT [UniProtKB:Q08345] xref: EMBL:AL662854 xref: EMBL:AL662870 xref: EMBL:AL773541 xref: EMBL:AL773589 xref: EMBL:BA000025 xref: EMBL:BC008716 xref: EMBL:BC013400 xref: EMBL:L11315 xref: EMBL:L20817 xref: EMBL:L57508 xref: EMBL:U48705 xref: EMBL:X74979 xref: EMBL:X98208 xref: EMBL:X99023 xref: EMBL:X99024 xref: EMBL:X99025 xref: EMBL:X99026 xref: EMBL:X99027 xref: EMBL:X99028 xref: EMBL:X99029 xref: EMBL:X99030 xref: EMBL:X99031 xref: EMBL:X99032 xref: EMBL:X99033 xref: EMBL:X99034 xref: EMBL:Z29093 xref: HGNC:HGNC:2730 xref: UniGene:Hs.631988 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006158 ! DDR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004454 name: DDX11_human def: "Probable ATP-dependent RNA helicase DDX11 gene" [UniProtKB:Q96FC9] synonym: "CHL1" EXACT [UniProtKB:Q96FC9] synonym: "CHLR1" EXACT [UniProtKB:Q96FC9] synonym: "KRG2" EXACT [UniProtKB:Q96FC9] xref: EMBL:BC050069 xref: EMBL:BC050522 xref: EMBL:U33833 xref: EMBL:U75967 xref: EMBL:U75968 xref: EMBL:X99583 xref: HGNC:HGNC:2736 xref: UniGene:Hs.443960 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002037 ! DDX11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004455 name: DDX12_human def: "Probable ATP-dependent RNA helicase DDX12 gene" [UniProtKB:Q92771] synonym: "CHLR2" EXACT [UniProtKB:Q92771] xref: EMBL:AC092821 xref: EMBL:AC141557 xref: EMBL:U33834 xref: HGNC:HGNC:2737 xref: UniGene:Hs.504688 xref: UniGene:Hs.705570 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002017 ! DDX12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004457 name: DDX24_human def: "ATP-dependent RNA helicase DDX24 gene" [UniProtKB:Q9GZR7] xref: EMBL:AF214731 xref: EMBL:AK025162 xref: EMBL:AL136886 xref: EMBL:BC008847 xref: EMBL:BC009406 xref: HGNC:HGNC:13266 xref: UniGene:Hs.510328 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006183 ! DDX24_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004458 name: DDX3X_human def: "ATP-dependent RNA helicase DDX3X gene" [UniProtKB:O00571] synonym: "DBX" EXACT [UniProtKB:O00571] synonym: "DDX3" EXACT [UniProtKB:O00571] xref: EMBL:AF000982 xref: EMBL:AF000983 xref: EMBL:AF061337 xref: EMBL:BC011819 xref: EMBL:U50553 xref: HGNC:HGNC:2745 xref: UniGene:Hs.380774 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005773 ! DDX3X_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004459 name: DDX5_human def: "Probable ATP-dependent RNA helicase DDX5 gene" [UniProtKB:P17844] synonym: "G17P1" EXACT [UniProtKB:P17844] synonym: "HELR" EXACT [UniProtKB:P17844] synonym: "HLR1" EXACT [UniProtKB:P17844] xref: EMBL:AF015812 xref: EMBL:AJ010931 xref: EMBL:BC016027 xref: EMBL:BT006943 xref: EMBL:X15729 xref: EMBL:X52104 xref: HGNC:HGNC:2746 xref: UniGene:Hs.279806 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005729 ! DDX5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004460 name: DDX6_human def: "Probable ATP-dependent RNA helicase DDX6 gene" [UniProtKB:P26196] synonym: "HLR2" EXACT [UniProtKB:P26196] synonym: "RCK" EXACT [UniProtKB:P26196] xref: EMBL:BC065007 xref: EMBL:D17532 xref: EMBL:Z11685 xref: HGNC:HGNC:2747 xref: UniGene:Hs.654366 xref: UniGene:Hs.702484 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006013 ! DDX6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004461 name: DEC1_human def: "Deleted in esophageal cancer 1 gene" [UniProtKB:Q9P2X7] synonym: "CTS9" EXACT [UniProtKB:Q9P2X7] xref: EMBL:AB022761 xref: EMBL:AL714001 xref: HGNC:HGNC:23658 xref: UniGene:Hs.148841 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002189 ! DEC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004462 name: DEFA1_human def: "Neutrophil defensin 1 precursor gene" [UniProtKB:P59665] synonym: "DEF1" EXACT [UniProtKB:P59665] synonym: "DEFA2" EXACT [UniProtKB:P59665] synonym: "MRS" EXACT [UniProtKB:P59665] xref: EMBL:BC069423 xref: EMBL:L12690 xref: EMBL:M21130 xref: EMBL:M26602 xref: EMBL:X52053 xref: HGNC:HGNC:2761 xref: UniGene:Hs.380781 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006339 ! DEF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004466 name: DHCR24_human def: "24-dehydrocholesterol reductase precursor gene" [UniProtKB:Q15392] synonym: "KIAA0018" EXACT [UniProtKB:Q15392] xref: EMBL:AF261758 xref: EMBL:AF398336 xref: EMBL:AF398337 xref: EMBL:AF398338 xref: EMBL:AF398339 xref: EMBL:AF398340 xref: EMBL:AF398341 xref: EMBL:AF398342 xref: EMBL:BC004375 xref: EMBL:BC011669 xref: EMBL:D13643 xref: HGNC:HGNC:2859 xref: UniGene:Hs.498727 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001806 ! DHC24_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004468 name: DHRS2_human def: "Dehydrogenase/reductase SDR family member 2 gene" [UniProtKB:Q13268] xref: EMBL:AF244132 xref: EMBL:BC007339 xref: EMBL:U31875 xref: HGNC:HGNC:18349 xref: UniGene:Hs.272499 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005756 ! DHRS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004471 name: CCDC85B_human def: "Delta-interacting protein A gene" [UniProtKB:Q15834] synonym: "DIPA" EXACT [UniProtKB:Q15834] xref: EMBL:BC008796 xref: EMBL:U63825 xref: HGNC:HGNC:24926 xref: UniGene:Hs.66713 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005625 ! DIPA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004473 name: DIRAS3_human def: "GTP-binding protein Di-Ras3 gene" [UniProtKB:O95661] synonym: "ARHI" EXACT [UniProtKB:O95661] synonym: "NOEY2" EXACT [UniProtKB:O95661] synonym: "RHOI" EXACT [UniProtKB:O95661] xref: EMBL:AF202543 xref: EMBL:AL157407 xref: EMBL:BC005362 xref: EMBL:CR541870 xref: EMBL:CR541892 xref: EMBL:U96750 xref: HGNC:HGNC:687 xref: UniGene:Hs.194695 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001453 ! DIRA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004474 name: DISC1_human def: "Disrupted in schizophrenia 1 protein gene" [UniProtKB:Q9NRI5] synonym: "KIAA0457" EXACT [UniProtKB:Q9NRI5] xref: EMBL:AB007926 xref: EMBL:AF222980 xref: EMBL:AF222983 xref: EMBL:AF222987 xref: EMBL:AJ506177 xref: EMBL:AJ506178 xref: EMBL:AL136171 xref: EMBL:AL161743 xref: EMBL:AL359543 xref: EMBL:AL445200 xref: EMBL:AL450284 xref: EMBL:AL626763 xref: HGNC:HGNC:2888 xref: UniGene:Hs.13318 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005591 ! DISC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004477 name: DLEC1_human def: "Deleted in lung and esophageal cancer protein 1 gene" [UniProtKB:Q9Y238] synonym: "DLC1" EXACT [UniProtKB:Q9Y238] xref: EMBL:AB020522 xref: EMBL:AB026898 xref: EMBL:AL137282 xref: EMBL:AL137706 xref: HGNC:HGNC:2899 xref: UniGene:Hs.699962 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002247 ! DLEC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004478 name: DLG1_human def: "Disks large homolog 1 gene" [UniProtKB:Q12959] xref: EMBL:U13896 xref: EMBL:U13897 xref: HGNC:HGNC:2900 xref: UniGene:Hs.292549 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001736 ! DLG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004479 name: DLG5_human def: "Disks large homolog 5 gene" [UniProtKB:Q8TDM6] synonym: "KIAA0583" EXACT [UniProtKB:Q8TDM6] synonym: "PDLG" EXACT [UniProtKB:Q8TDM6] xref: EMBL:AB011155 xref: EMBL:AB091676 xref: EMBL:AF352033 xref: EMBL:AF352034 xref: EMBL:AL391421 xref: EMBL:AL450306 xref: EMBL:BC073996 xref: EMBL:BC117695 xref: EMBL:U61843 xref: HGNC:HGNC:2904 xref: UniGene:Hs.652690 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001993 ! DLG5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004480 name: DLG7_human def: "Disks large-associated protein DLG7 gene" [UniProtKB:Q15398] synonym: "KIAA0008" EXACT [UniProtKB:Q15398] xref: EMBL:AB076695 xref: EMBL:BC010658 xref: EMBL:BC016276 xref: EMBL:BT007344 xref: EMBL:D13633 xref: HGNC:HGNC:16864 xref: UniGene:Hs.77695 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001807 ! DLG7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004482 name: DYNLRB1_human def: "Dynein light chain roadblock-type 1 gene" [UniProtKB:Q9NP97] synonym: "BITH" EXACT [UniProtKB:Q9NP97] synonym: "DNCL2A" EXACT [UniProtKB:Q9NP97] synonym: "DNLC2A" EXACT [UniProtKB:Q9NP97] synonym: "HSPC162" EXACT [UniProtKB:Q9NP97] xref: EMBL:AF132750 xref: EMBL:AF161511 xref: EMBL:AF165516 xref: EMBL:AF178431 xref: EMBL:AL109923 xref: EMBL:AL136173 xref: EMBL:AY026513 xref: EMBL:BC002481 xref: EMBL:BC007223 xref: HGNC:HGNC:15468 xref: UniGene:Hs.593920 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005562 ! DLRB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004483 name: DMAP1_human def: "DNA methyltransferase 1-associated protein 1 gene" [UniProtKB:Q9NPF5] synonym: "KIAA1425" EXACT [UniProtKB:Q9NPF5] xref: EMBL:AB037846 xref: EMBL:AF265228 xref: EMBL:AK021605 xref: EMBL:AL035417 xref: EMBL:AL136657 xref: EMBL:AL137200 xref: EMBL:AM393614 xref: EMBL:BC002855 xref: EMBL:BC008053 xref: EMBL:BX537895 xref: HGNC:HGNC:18291 xref: UniGene:Hs.8008 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005365 ! DMAP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004484 name: DMBT1_human def: "Deleted in malignant brain tumors 1 protein precursor gene" [UniProtKB:Q9UGM3] synonym: "GP340" EXACT [UniProtKB:Q9UGM3] xref: EMBL:AB020851 xref: EMBL:AB209691 xref: EMBL:AF159456 xref: EMBL:AJ000342 xref: EMBL:AJ243211 xref: EMBL:AJ243212 xref: EMBL:AJ243224 xref: EMBL:AJ297935 xref: EMBL:AL603764 xref: EMBL:BX640988 xref: HGNC:HGNC:2926 xref: UniGene:Hs.279611 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002197 ! DMBT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004485 name: DMC1_human def: "Meiotic recombination protein DMC1/LIM15 homolog gene" [UniProtKB:Q14565] synonym: "DMC1H" EXACT [UniProtKB:Q14565] synonym: "LIM15" EXACT [UniProtKB:Q14565] xref: EMBL:AL022320 xref: EMBL:AY520538 xref: EMBL:BC125163 xref: EMBL:BC125164 xref: EMBL:CR456486 xref: EMBL:D63882 xref: EMBL:D64108 xref: HGNC:HGNC:2927 xref: UniGene:Hs.339396 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001784 ! DMC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004486 name: DMWD_human def: "Dystrophia myotonica WD repeat-containing protein gene" [UniProtKB:Q09019] synonym: "DM9" EXACT [UniProtKB:Q09019] xref: EMBL:AC011530 xref: EMBL:L08835 xref: EMBL:L19267 xref: HGNC:HGNC:2936 xref: UniGene:Hs.515474 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001726 ! DMWD_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004487 name: DNAJA1_human def: "DnaJ homolog subfamily A member 1 gene" [UniProtKB:P31689] synonym: "DNAJ2" EXACT [UniProtKB:P31689] synonym: "HDJ2" EXACT [UniProtKB:P31689] synonym: "HSJ2" EXACT [UniProtKB:P31689] synonym: "HSPF4" EXACT [UniProtKB:P31689] xref: EMBL:BC008182 xref: EMBL:BT007292 xref: EMBL:D13388 xref: EMBL:L08069 xref: HGNC:HGNC:5229 xref: UniGene:Hs.445203 xref: UniGene:Hs.703256 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005835 ! DNJA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004488 name: DNAJA2_human def: "DnaJ homolog subfamily A member 2 gene" [UniProtKB:O60884] synonym: "CPR3" EXACT [UniProtKB:O60884] synonym: "HIRIP4" EXACT [UniProtKB:O60884] xref: EMBL:AF011793 xref: EMBL:AJ001309 xref: EMBL:BC013044 xref: EMBL:BC015809 xref: EMBL:Y13350 xref: HGNC:HGNC:14884 xref: UniGene:Hs.368078 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001418 ! DNJA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004489 name: DNAJA3_human def: "DnaJ homolog subfamily A member 3, mitochondrial precursor gene" [UniProtKB:Q96EY1] synonym: "HCA57" EXACT [UniProtKB:Q96EY1] synonym: "TID1" EXACT [UniProtKB:Q96EY1] xref: EMBL:AF061749 xref: EMBL:AF244136 xref: EMBL:AF411044 xref: EMBL:BC007225 xref: EMBL:BC011855 xref: EMBL:BC012343 xref: EMBL:BC014062 xref: EMBL:BC020248 xref: EMBL:BC030145 xref: EMBL:BC032100 xref: HGNC:HGNC:11808 xref: UniGene:Hs.459779 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005818 ! DNJA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004490 name: DNAJB6_human def: "DnaJ homolog subfamily B member 6 gene" [UniProtKB:O75190] synonym: "HSJ2" EXACT [UniProtKB:O75190] synonym: "MRJ" EXACT [UniProtKB:O75190] synonym: "MSJ1" EXACT [UniProtKB:O75190] xref: EMBL:AB014888 xref: EMBL:AB015798 xref: EMBL:AB015799 xref: EMBL:AB209859 xref: EMBL:AC079306 xref: EMBL:AF060703 xref: EMBL:AF075601 xref: EMBL:AF080569 xref: EMBL:AK223601 xref: EMBL:AL136707 xref: EMBL:BC000177 xref: EMBL:BC002446 xref: EMBL:CH236954 xref: EMBL:CR533498 xref: HGNC:HGNC:14888 xref: UniGene:Hs.490745 xref: UniGene:Hs.593923 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005696 ! DNJB6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004491 name: DNAJB9_human def: "DnaJ homolog subfamily B member 9 gene" [UniProtKB:Q9UBS3] synonym: "MDG1" EXACT [UniProtKB:Q9UBS3] synonym: "UNQ743/PRO1471" EXACT [UniProtKB:Q9UBS3] xref: EMBL:AB026908 xref: EMBL:AF083247 xref: EMBL:AL080081 xref: EMBL:AY359045 xref: EMBL:BC028912 xref: HGNC:HGNC:6968 xref: UniGene:Hs.6790 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006137 ! DNJB9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004492 name: LIG1_human def: "DNA ligase 1 gene" [UniProtKB:P18858] xref: EMBL:AF527418 xref: EMBL:BC108318 xref: EMBL:M36067 xref: HGNC:HGNC:6598 xref: UniGene:Hs.1770 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001534 ! DNL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004493 name: LIG3_human def: "DNA ligase 3 gene" [UniProtKB:P49916] xref: EMBL:AF491645 xref: EMBL:U40671 xref: EMBL:X84740 xref: HGNC:HGNC:6600 xref: UniGene:Hs.100299 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001638 ! DNL3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004494 name: LIG4_human def: "DNA ligase 4 gene" [UniProtKB:P49917] xref: EMBL:AF479264 xref: EMBL:AL157762 xref: EMBL:BC037491 xref: EMBL:X83441 xref: HGNC:HGNC:6601 xref: UniGene:Hs.166091 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001639 ! DNL4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004495 name: DNMT3B_human def: "DNA (cytosine-5)-methyltransferase 3B gene" [UniProtKB:Q9UBC3] xref: EMBL:AF129267 xref: EMBL:AF129268 xref: EMBL:AF129269 xref: EMBL:AF156487 xref: EMBL:AF156488 xref: EMBL:AF176228 xref: EMBL:AF331857 xref: EMBL:AL035071 xref: HGNC:HGNC:2979 xref: UniGene:Hs.643024 xref: UniGene:Hs.655708 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005423 ! DNM3B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004497 name: APPL1_human def: "DCC-interacting protein 13-alpha gene" [UniProtKB:Q9UKG1] synonym: "APPL" EXACT [UniProtKB:Q9UKG1] synonym: "DIP13A" EXACT [UniProtKB:Q9UKG1] synonym: "KIAA1428" EXACT [UniProtKB:Q9UKG1] xref: EMBL:AB037849 xref: EMBL:AF169797 xref: EMBL:AF424738 xref: EMBL:BC028599 xref: HGNC:HGNC:24035 xref: UniGene:Hs.476415 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002219 ! DP13A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004498 name: APPL2_human def: "DCC-interacting protein 13-beta gene" [UniProtKB:Q8NEU8] synonym: "DIP13B" EXACT [UniProtKB:Q8NEU8] xref: EMBL:AK001521 xref: EMBL:AY113704 xref: EMBL:BC033731 xref: HGNC:HGNC:18242 xref: UniGene:Hs.506603 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001980 ! DP13B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004499 name: DPH1_human def: "Diphthamide biosynthesis protein 1 gene" [UniProtKB:Q9BZG8] synonym: "DPH2L" EXACT [UniProtKB:Q9BZG8] synonym: "DPH2L1" EXACT [UniProtKB:Q9BZG8] synonym: "OVCA1" EXACT [UniProtKB:Q9BZG8] xref: EMBL:AF321876 xref: EMBL:BC003099 xref: EMBL:BC096088 xref: EMBL:BT019878 xref: EMBL:S81752 xref: EMBL:U34880 xref: HGNC:HGNC:3003 xref: UniGene:Hs.513856 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002117 ! DPH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004500 name: POLA2_human def: "DNA polymerase subunit alpha B gene" [UniProtKB:Q14181] xref: EMBL:BC001347 xref: EMBL:BC002990 xref: EMBL:CR456737 xref: EMBL:L24559 xref: HGNC:HGNC:30073 xref: UniGene:Hs.201897 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005509 ! DPOA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004501 name: POLD1_human def: "DNA polymerase delta catalytic subunit gene" [UniProtKB:P28340] synonym: "POLD" EXACT [UniProtKB:P28340] xref: EMBL:AY129569 xref: EMBL:BC008800 xref: EMBL:M80397 xref: EMBL:M81735 xref: HGNC:HGNC:9175 xref: UniGene:Hs.279413 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001564 ! DPOD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004502 name: POLD2_human def: "DNA polymerase subunit delta-2 gene" [UniProtKB:P49005] xref: EMBL:AF239710 xref: EMBL:AY116646 xref: EMBL:BC000459 xref: EMBL:U21090 xref: HGNC:HGNC:9176 xref: UniGene:Hs.306791 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005883 ! DPOD2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004503 name: POLD3_human def: "DNA polymerase subunit delta-3 gene" [UniProtKB:Q15054] synonym: "KIAA0039" EXACT [UniProtKB:Q15054] xref: EMBL:D26018 xref: HGNC:HGNC:20932 xref: UniGene:Hs.82502 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005884 ! DPOD3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004504 name: POLD4_human def: "DNA polymerase subunit delta-4 gene" [UniProtKB:Q9HCU8] synonym: "POLDS" EXACT [UniProtKB:Q9HCU8] xref: EMBL:AF179890 xref: EMBL:AY928482 xref: HGNC:HGNC:14106 xref: UniGene:Hs.523829 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005882 ! DPOD4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004505 name: POLE_human def: "DNA polymerase epsilon catalytic subunit A gene" [UniProtKB:Q07864] synonym: "POLE1" EXACT [UniProtKB:Q07864] xref: EMBL:AY273166 xref: EMBL:L09561 xref: EMBL:S60080 xref: EMBL:U49356 xref: HGNC:HGNC:9177 xref: UniGene:Hs.524871 xref: UniGene:Hs.657680 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001724 ! DPOE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004506 name: POLE2_human def: "DNA polymerase epsilon subunit 2 gene" [UniProtKB:P56282] synonym: "DPE2" EXACT [UniProtKB:P56282] xref: EMBL:AF025840 xref: EMBL:AF036899 xref: EMBL:AF387021 xref: EMBL:AF387022 xref: EMBL:AF387023 xref: EMBL:AF387024 xref: EMBL:AF387025 xref: EMBL:AF387026 xref: EMBL:AF387027 xref: EMBL:AF387028 xref: EMBL:AF387029 xref: EMBL:AF387030 xref: EMBL:AF387031 xref: EMBL:AF387032 xref: EMBL:AF387033 xref: EMBL:AF387034 xref: EMBL:BC126218 xref: EMBL:BC126220 xref: HGNC:HGNC:9178 xref: UniGene:Hs.162777 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005904 ! DPOE2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004507 name: POLE3_human def: "DNA polymerase epsilon subunit 3 gene" [UniProtKB:Q9NRF9] synonym: "CHRAC17" EXACT [UniProtKB:Q9NRF9] xref: EMBL:AF226077 xref: EMBL:AF261689 xref: EMBL:AK074629 xref: EMBL:AK074762 xref: EMBL:AK074782 xref: EMBL:AL137066 xref: EMBL:AY720898 xref: EMBL:BC003166 xref: EMBL:BC004170 xref: EMBL:DQ072116 xref: HGNC:HGNC:13546 xref: UniGene:Hs.108112 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005885 ! DPOE3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004508 name: POLE4_human def: "DNA polymerase epsilon subunit 4 gene" [UniProtKB:Q9NR33] xref: EMBL:AC007400 xref: EMBL:AF261688 xref: EMBL:BC031331 xref: HGNC:HGNC:18755 xref: UniGene:Hs.469060 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005905 ! DPOE4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004509 name: POLA1_human def: "DNA polymerase alpha catalytic subunit gene" [UniProtKB:P09884] synonym: "POLA" EXACT [UniProtKB:P09884] xref: EMBL:AY275833 xref: EMBL:M64481 xref: EMBL:X06745 xref: HGNC:HGNC:9173 xref: UniGene:Hs.567319 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001503 ! DPOLA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004510 name: CRMP1_human def: "Dihydropyrimidinase-related protein 1 gene" [UniProtKB:Q14194] synonym: "DPYSL1" EXACT [UniProtKB:Q14194] xref: EMBL:AF096140 xref: EMBL:AF096141 xref: EMBL:AF096142 xref: EMBL:AF096143 xref: EMBL:AF096144 xref: EMBL:AF096145 xref: EMBL:AF096146 xref: EMBL:AF096147 xref: EMBL:AF096148 xref: EMBL:AF096149 xref: EMBL:AF096150 xref: EMBL:AF096151 xref: EMBL:AF096152 xref: EMBL:BC000252 xref: EMBL:BC007613 xref: EMBL:BT006806 xref: EMBL:D78012 xref: EMBL:U17278 xref: HGNC:HGNC:2365 xref: UniGene:Hs.135270 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006074 ! DPYL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004511 name: DRAP1_human def: "Dr1-associated corepressor gene" [UniProtKB:Q14919] xref: EMBL:BC010025 xref: EMBL:U41843 xref: EMBL:X96506 xref: HGNC:HGNC:3019 xref: UniGene:Hs.356742 xref: UniGene:Hs.381222 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0040686 ! NC2A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004512 name: DBN1_human def: "Drebrin gene" [UniProtKB:Q16643] synonym: "D0S117E" EXACT [UniProtKB:Q16643] xref: EMBL:AL110225 xref: EMBL:BC000283 xref: EMBL:BC007281 xref: EMBL:BC007567 xref: EMBL:D17530 xref: EMBL:U00802 xref: HGNC:HGNC:2695 xref: UniGene:Hs.130316 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006302 ! DREB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004513 name: DSN1_human def: "Kinetochore-associated protein DSN1 homolog gene" [UniProtKB:Q9H410] synonym: "C20orf172" EXACT [UniProtKB:Q9H410] xref: EMBL:AK023408 xref: EMBL:AK093031 xref: EMBL:AL132768 xref: EMBL:BC058899 xref: HGNC:HGNC:16165 xref: UniGene:Hs.632268 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002134 ! DSN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004514 name: SHFM1_human def: "26 proteasome complex subunit DSS1 gene" [UniProtKB:P60896] synonym: "DSS1" EXACT [UniProtKB:P60896] synonym: "SHFDG1" EXACT [UniProtKB:P60896] xref: EMBL:AC073230 xref: EMBL:BC032782 xref: EMBL:U41515 xref: HGNC:HGNC:10845 xref: UniGene:Hs.489201 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005586 ! DSS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004515 name: DTNBP1_human def: "Dysbindin gene" [UniProtKB:Q96EV8] synonym: "My031" EXACT [UniProtKB:Q96EV8] xref: EMBL:AF061734 xref: EMBL:AF394226 xref: EMBL:AK054593 xref: EMBL:AL021978 xref: EMBL:AL022343 xref: EMBL:AL136637 xref: EMBL:AY265460 xref: EMBL:BC011912 xref: HGNC:HGNC:17328 xref: UniGene:Hs.571148 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005258 ! DTBP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004516 name: DTL_human def: "Denticleless protein homolog gene" [UniProtKB:Q9NZJ0] synonym: "CDT2" EXACT [UniProtKB:Q9NZJ0] synonym: "CDW1" EXACT [UniProtKB:Q9NZJ0] synonym: "DCAF2" EXACT [UniProtKB:Q9NZJ0] synonym: "L2DTL" EXACT [UniProtKB:Q9NZJ0] synonym: "RAMP" EXACT [UniProtKB:Q9NZJ0] xref: EMBL:AC092814 xref: EMBL:AF195765 xref: EMBL:AF345896 xref: EMBL:AK000742 xref: EMBL:AK001206 xref: EMBL:AK001261 xref: EMBL:AK027651 xref: EMBL:AL592297 xref: EMBL:AL606468 xref: EMBL:BC033297 xref: EMBL:BC033540 xref: EMBL:DQ641253 xref: HGNC:HGNC:30288 xref: UniGene:Hs.656473 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005656 ! DTL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004517 name: DTNA_human def: "Dystrobrevin alpha gene" [UniProtKB:Q9Y4J8] synonym: "DRP3" EXACT [UniProtKB:Q9Y4J8] xref: EMBL:AJ009668 xref: EMBL:U26742 xref: EMBL:U26743 xref: EMBL:U26744 xref: EMBL:U46744 xref: EMBL:U46745 xref: EMBL:U46746 xref: EMBL:U84529 xref: EMBL:U84530 xref: EMBL:U84531 xref: EMBL:U84532 xref: EMBL:U84533 xref: EMBL:U84534 xref: EMBL:U84535 xref: EMBL:U84536 xref: EMBL:U84537 xref: EMBL:U84538 xref: EMBL:U84539 xref: EMBL:U84540 xref: EMBL:U84541 xref: EMBL:U84542 xref: EMBL:U84543 xref: EMBL:U84544 xref: EMBL:U84545 xref: EMBL:U84546 xref: EMBL:U84547 xref: EMBL:U84548 xref: EMBL:U84549 xref: EMBL:U84550 xref: EMBL:U84551 xref: HGNC:HGNC:3057 xref: UniGene:Hs.643454 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005954 ! DTNA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004518 name: DTYMK_human def: "Thymidylate kinase gene" [UniProtKB:P23919] synonym: "CDC8" EXACT [UniProtKB:P23919] synonym: "TMPK" EXACT [UniProtKB:P23919] synonym: "TYMK" EXACT [UniProtKB:P23919] xref: EMBL:BC001827 xref: EMBL:CR541986 xref: EMBL:L16991 xref: EMBL:X54729 xref: HGNC:HGNC:3061 xref: UniGene:Hs.471873 xref: UniGene:Hs.647895 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001550 ! KTHY_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004520 name: DUSP13_human def: "Dual specificity protein phosphatase 13 gene" [UniProtKB:Q9UII6] synonym: "TMDP" EXACT [UniProtKB:Q9UII6] xref: EMBL:AB027004 xref: EMBL:AB103375 xref: EMBL:AL392111 xref: EMBL:BC009778 xref: HGNC:HGNC:19681 xref: UniGene:Hs.178170 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002207 ! DUS13_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004521 name: DUSP1_human def: "Dual specificity protein phosphatase 1 gene" [UniProtKB:P28562] synonym: "CL100" EXACT [UniProtKB:P28562] synonym: "MKP1" EXACT [UniProtKB:P28562] synonym: "PTPN10" EXACT [UniProtKB:P28562] synonym: "VH1" EXACT [UniProtKB:P28562] xref: EMBL:BC022463 xref: EMBL:DQ301957 xref: EMBL:X68277 xref: HGNC:HGNC:3064 xref: UniGene:Hs.171695 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001566 ! DUS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004524 name: DVL2_human def: "Segment polarity protein dishevelled homolog DVL-2 gene" [UniProtKB:O14641] xref: EMBL:AF006012 xref: EMBL:BC014844 xref: HGNC:HGNC:3086 xref: UniGene:Hs.118640 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005211 ! DVL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004525 name: DNAH9_human def: "Dynein heavy chain 9, axonemal gene" [UniProtKB:Q9NYC9] synonym: "DNAH17L" EXACT [UniProtKB:Q9NYC9] synonym: "DNAL1" EXACT [UniProtKB:Q9NYC9] xref: EMBL:AF257737 xref: EMBL:AJ132088 xref: EMBL:AJ404468 xref: HGNC:HGNC:2953 xref: UniGene:Hs.567259 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006028 ! DYH9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004526 name: DYNC1H1_human def: "Cytoplasmic dynein 1 heavy chain 1 gene" [UniProtKB:Q14204] synonym: "DHC1" EXACT [UniProtKB:Q14204] synonym: "DNCH1" EXACT [UniProtKB:Q14204] synonym: "DNCL" EXACT [UniProtKB:Q14204] synonym: "DNECL" EXACT [UniProtKB:Q14204] synonym: "DYHC" EXACT [UniProtKB:Q14204] synonym: "KIAA0325" EXACT [UniProtKB:Q14204] xref: EMBL:AB002323 xref: EMBL:AY682080 xref: EMBL:BC021297 xref: EMBL:L23958 xref: EMBL:U53530 xref: HGNC:HGNC:2961 xref: UniGene:Hs.649497 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001780 ! DYHC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004527 name: DYNLL1_human def: "Dynein light chain 1, cytoplasmic gene" [UniProtKB:P63167] synonym: "DLC1" EXACT [UniProtKB:P63167] synonym: "DNCL1" EXACT [UniProtKB:P63167] synonym: "DNCLC1" EXACT [UniProtKB:P63167] synonym: "HDLC1" EXACT [UniProtKB:P63167] xref: EMBL:CR407672 xref: EMBL:U32944 xref: HGNC:HGNC:15476 xref: UniGene:Hs.5120 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006226 ! DYL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004528 name: DNM2_human def: "Dynamin-2 gene" [UniProtKB:P50570] synonym: "DYN2" EXACT [UniProtKB:P50570] xref: EMBL:AC007229 xref: EMBL:BC039596 xref: EMBL:BC054501 xref: EMBL:L36983 xref: HGNC:HGNC:2974 xref: UniGene:Hs.211463 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001643 ! DYN2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004529 name: DYRK2_human def: "Dual specificity tyrosine-phosphorylation-regulated kinase 2 gene" [UniProtKB:Q92630] xref: EMBL:BC005809 xref: EMBL:BC006375 xref: EMBL:Y09216 xref: EMBL:Y13493 xref: HGNC:HGNC:3093 xref: UniGene:Hs.173135 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005265 ! DYRK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004530 name: EIF2AK1_human def: "Eukaryotic translation initiation factor 2-alpha kinase 1 gene" [UniProtKB:Q9BQI3] synonym: "HRI" EXACT [UniProtKB:Q9BQI3] synonym: "KIAA1369" EXACT [UniProtKB:Q9BQI3] synonym: "PRO1362" EXACT [UniProtKB:Q9BQI3] xref: EMBL:AB037790 xref: EMBL:AF116634 xref: EMBL:AF147094 xref: EMBL:AF181071 xref: EMBL:AF183414 xref: EMBL:AF255050 xref: EMBL:AK075192 xref: EMBL:AL136563 xref: EMBL:AL834494 xref: EMBL:BC006524 xref: HGNC:HGNC:24921 xref: UniGene:Hs.520205 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005674 ! E2AK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004531 name: EIF2AK2_human def: "Interferon-induced, double-stranded RNA-activated protein kinase gene" [UniProtKB:P19525] synonym: "PKR" EXACT [UniProtKB:P19525] synonym: "PRKR" EXACT [UniProtKB:P19525] xref: EMBL:AC007899 xref: EMBL:AF167460 xref: EMBL:AF167462 xref: EMBL:AF167463 xref: EMBL:AF167464 xref: EMBL:AF167465 xref: EMBL:AF167466 xref: EMBL:AF167468 xref: EMBL:AF167470 xref: EMBL:AF167472 xref: EMBL:AY228338 xref: EMBL:BC093676 xref: EMBL:BC101475 xref: EMBL:M35663 xref: EMBL:M85294 xref: EMBL:U50634 xref: EMBL:U50635 xref: EMBL:U50636 xref: EMBL:U50637 xref: EMBL:U50638 xref: EMBL:U50639 xref: EMBL:U50640 xref: EMBL:U50641 xref: EMBL:U50642 xref: EMBL:U50643 xref: EMBL:U50644 xref: EMBL:U50645 xref: EMBL:U50646 xref: EMBL:U50647 xref: EMBL:U50648 xref: HGNC:HGNC:9437 xref: UniGene:Hs.131431 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001535 ! E2AK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004532 name: EIF2AK3_human def: "Eukaryotic translation initiation factor 2-alpha kinase 3 precursor gene" [UniProtKB:Q9NZJ5] synonym: "PEK" EXACT [UniProtKB:Q9NZJ5] synonym: "PERK" EXACT [UniProtKB:Q9NZJ5] xref: EMBL:AF110146 xref: EMBL:AF193339 xref: EMBL:AF284604 xref: EMBL:AF284605 xref: EMBL:AF284606 xref: EMBL:AF284607 xref: EMBL:AF284608 xref: EMBL:AF284609 xref: EMBL:AF284610 xref: EMBL:AF284611 xref: EMBL:AF284612 xref: EMBL:AF284613 xref: EMBL:AF284614 xref: EMBL:AF284615 xref: EMBL:BC126356 xref: HGNC:HGNC:3255 xref: UniGene:Hs.591589 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006015 ! E2AK3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004533 name: E2F1_human def: "Transcription factor E2F1 gene" [UniProtKB:Q01094] synonym: "RBBP3" EXACT [UniProtKB:Q01094] xref: EMBL:AF516106 xref: EMBL:AL121906 xref: EMBL:BC050369 xref: EMBL:BC058902 xref: EMBL:M96577 xref: EMBL:S49592 xref: EMBL:S74230 xref: EMBL:U47675 xref: EMBL:U47676 xref: EMBL:U47677 xref: HGNC:HGNC:3113 xref: UniGene:Hs.654393 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001713 ! E2F1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004534 name: E2F2_human def: "Transcription factor E2F2 gene" [UniProtKB:Q14209] xref: EMBL:AF518877 xref: EMBL:AL021154 xref: EMBL:BC053676 xref: EMBL:L22846 xref: HGNC:HGNC:3114 xref: UniGene:Hs.194333 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001781 ! E2F2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004535 name: E2F3_human def: "Transcription factor E2F3 gene" [UniProtKB:O00716] synonym: "KIAA0075" EXACT [UniProtKB:O00716] xref: EMBL:AF547386 xref: EMBL:AL132775 xref: EMBL:AL136303 xref: EMBL:D38550 xref: EMBL:Y10479 xref: HGNC:HGNC:3115 xref: UniGene:Hs.269408 xref: UniGene:Hs.703174 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001352 ! E2F3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004536 name: E2F4_human def: "Transcription factor E2F4 gene" [UniProtKB:Q16254] xref: EMBL:AC040160 xref: EMBL:AF250378 xref: EMBL:AF527540 xref: EMBL:BC033180 xref: EMBL:CH471092 xref: EMBL:S75174 xref: EMBL:U15641 xref: EMBL:X86096 xref: HGNC:HGNC:3118 xref: UniGene:Hs.108371 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001817 ! E2F4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004538 name: E2F6_human def: "Transcription factor E2F6 gene" [UniProtKB:O75461] xref: EMBL:AC099344 xref: EMBL:AF041381 xref: EMBL:AF059292 xref: EMBL:AJ493061 xref: EMBL:AY083996 xref: EMBL:AY083997 xref: EMBL:BC008348 xref: EMBL:BC107740 xref: HGNC:HGNC:3120 xref: UniGene:Hs.603093 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001429 ! E2F6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004539 name: E2F7_human def: "Transcription factor E2F7 gene" [UniProtKB:Q96AV8] xref: EMBL:AC025161 xref: EMBL:AC079030 xref: EMBL:AK097677 xref: EMBL:BC016658 xref: EMBL:BC017481 xref: HGNC:HGNC:23820 xref: UniGene:Hs.416375 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002031 ! E2F7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004540 name: E2F8_human def: "Transcription factor E2F8 gene" [UniProtKB:A0AVK6] xref: EMBL:AB231781 xref: EMBL:AK026964 xref: EMBL:BC028244 xref: EMBL:BC090877 xref: EMBL:BC108700 xref: EMBL:BC126400 xref: EMBL:BC126402 xref: HGNC:HGNC:24727 xref: UniGene:Hs.523526 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001317 ! E2F8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004541 name: EAF1_human def: "ELL-associated factor 1 gene" [UniProtKB:Q96JC9] xref: EMBL:AF272973 xref: EMBL:BC041329 xref: HGNC:HGNC:20907 xref: UniGene:Hs.474479 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005363 ! EAF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004542 name: EDC3_human def: "Enhancer of mRNA-decapping protein 3 gene" [UniProtKB:Q96F86] synonym: "LSM16" EXACT [UniProtKB:Q96F86] synonym: "PP844" EXACT [UniProtKB:Q96F86] synonym: "YJDC" EXACT [UniProtKB:Q96F86] xref: EMBL:AF193058 xref: EMBL:AK024781 xref: EMBL:BC011534 xref: EMBL:BC021271 xref: HGNC:HGNC:26114 xref: UniGene:Hs.96852 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005717 ! EDC3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004543 name: EDC4_human def: "Enhancer of mRNA-decapping protein 4 gene" [UniProtKB:Q6P2E9] synonym: "HEDLS" EXACT [UniProtKB:Q6P2E9] xref: EMBL:AK128582 xref: EMBL:BC043616 xref: EMBL:BC053598 xref: EMBL:BC064567 xref: EMBL:L26339 xref: EMBL:U17474 xref: HGNC:HGNC:17157 xref: UniGene:Hs.75682 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005683 ! EDC4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004544 name: EDG4_human def: "Lysophosphatidic acid receptor Edg-4 gene" [UniProtKB:Q9HBW0] synonym: "LPA2" EXACT [UniProtKB:Q9HBW0] xref: EMBL:AC002306 xref: EMBL:AF011466 xref: EMBL:AF197929 xref: EMBL:AF233092 xref: EMBL:AY322548 xref: EMBL:BC025695 xref: HGNC:HGNC:3168 xref: UniGene:Hs.122575 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006043 ! EDG4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004545 name: EEF1A1_human def: "Elongation factor 1-alpha 1 gene" [UniProtKB:P68104] synonym: "EEF1A" EXACT [UniProtKB:P68104] synonym: "EF1A" EXACT [UniProtKB:P68104] synonym: "LENG7" EXACT [UniProtKB:P68104] xref: EMBL:AY043301 xref: EMBL:BC008587 xref: EMBL:BC009733 xref: EMBL:BC009875 xref: EMBL:BC010735 xref: EMBL:BC012891 xref: EMBL:BC014224 xref: EMBL:BC018150 xref: EMBL:BC018641 xref: EMBL:BC019669 xref: EMBL:BC021686 xref: EMBL:BC028674 xref: EMBL:BC038339 xref: EMBL:BC057391 xref: EMBL:BC066893 xref: EMBL:BC072385 xref: EMBL:BC082268 xref: EMBL:J04617 xref: EMBL:M29548 xref: EMBL:X03558 xref: EMBL:X03689 xref: EMBL:X16869 xref: HGNC:HGNC:3189 xref: UniGene:Hs.490287 xref: UniGene:Hs.520703 xref: UniGene:Hs.586423 xref: UniGene:Hs.644639 xref: UniGene:Hs.704732 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005831 ! EF1A1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004546 name: EEF1B2_human def: "Elongation factor 1-beta gene" [UniProtKB:P24534] synonym: "EEF1B" EXACT [UniProtKB:P24534] synonym: "EF1B" EXACT [UniProtKB:P24534] xref: EMBL:AC007383 xref: EMBL:BC000211 xref: EMBL:BC004931 xref: EMBL:BC067787 xref: EMBL:BT007079 xref: EMBL:CR456825 xref: EMBL:X60489 xref: EMBL:X60656 xref: HGNC:HGNC:3208 xref: UniGene:Hs.421608 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005752 ! EF1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004547 name: EEF1G_human def: "Elongation factor 1-gamma gene" [UniProtKB:P26641] synonym: "EF1G" EXACT [UniProtKB:P26641] synonym: "PRO1608" EXACT [UniProtKB:P26641] xref: EMBL:AF119850 xref: EMBL:BC000384 xref: EMBL:BC006509 xref: EMBL:BC006520 xref: EMBL:BC007949 xref: EMBL:BC009865 xref: EMBL:BC013918 xref: EMBL:BC015813 xref: EMBL:BC021974 xref: EMBL:BC028179 xref: EMBL:BC031012 xref: EMBL:BC067738 xref: EMBL:M55409 xref: EMBL:X63526 xref: EMBL:Z11531 xref: HGNC:HGNC:3213 xref: UniGene:Hs.144835 xref: UniGene:Hs.664670 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006079 ! EF1G_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004549 name: EFNB1_human def: "Ephrin-B1 precursor gene" [UniProtKB:P98172] synonym: "EFL-3" EXACT [UniProtKB:P98172] synonym: "EPLG2" EXACT [UniProtKB:P98172] synonym: "LERK2" EXACT [UniProtKB:P98172] xref: EMBL:AL136092 xref: EMBL:BC016649 xref: EMBL:BC052979 xref: EMBL:L37361 xref: EMBL:U09303 xref: EMBL:U09304 xref: HGNC:HGNC:3226 xref: UniGene:Hs.144700 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005815 ! EFNB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004550 name: EGFL6_human def: "EGF-like domain-containing protein 6 precursor gene" [UniProtKB:Q8IUX8] synonym: "MAEG" EXACT [UniProtKB:Q8IUX8] synonym: "PP648" EXACT [UniProtKB:Q8IUX8] synonym: "UNQ281/PRO320" EXACT [UniProtKB:Q8IUX8] xref: EMBL:AF186084 xref: EMBL:AF193055 xref: EMBL:AJ245671 xref: EMBL:AK075214 xref: EMBL:AL117610 xref: EMBL:AY358333 xref: EMBL:BC038587 xref: HGNC:HGNC:3235 xref: UniGene:Hs.12844 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001947 ! EGFL6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004551 name: EGFL7_human def: "EGF-like domain-containing protein 7 precursor gene" [UniProtKB:Q9UHF1] synonym: "MEGF7" EXACT [UniProtKB:Q9UHF1] synonym: "UNQ187/PRO1449" EXACT [UniProtKB:Q9UHF1] xref: EMBL:AB125649 xref: EMBL:AF186111 xref: EMBL:AL512735 xref: EMBL:AL590226 xref: EMBL:AY358901 xref: EMBL:AY358902 xref: EMBL:AY358903 xref: EMBL:BC012377 xref: EMBL:BC088371 xref: HGNC:HGNC:20594 xref: UniGene:Hs.91481 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005958 ! EGFL7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004552 name: EGFR_human def: "Epidermal growth factor receptor precursor gene" [UniProtKB:P00533] synonym: "ERBB1" EXACT [UniProtKB:P00533] xref: EMBL:AF125253 xref: EMBL:AF125538 xref: EMBL:AF125539 xref: EMBL:AF277897 xref: EMBL:AF288738 xref: EMBL:AY588246 xref: EMBL:M11234 xref: EMBL:M38425 xref: EMBL:U48722 xref: EMBL:U48723 xref: EMBL:U48724 xref: EMBL:U48725 xref: EMBL:U48726 xref: EMBL:U48727 xref: EMBL:U48728 xref: EMBL:U48729 xref: EMBL:U95089 xref: EMBL:X00588 xref: EMBL:X00663 xref: EMBL:X06370 xref: HGNC:HGNC:3236 xref: UniGene:Hs.488293 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001462 ! EGFR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004553 name: EGF_human def: "Pro-epidermal growth factor precursor gene" [UniProtKB:P01133] xref: EMBL:AY506357 xref: EMBL:BC093731 xref: EMBL:BC113461 xref: EMBL:X04571 xref: HGNC:HGNC:3229 xref: UniGene:Hs.419815 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001470 ! EGF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004554 name: EGR2_human def: "Early growth response protein 2 gene" [UniProtKB:P11161] synonym: "KROX20" EXACT [UniProtKB:P11161] xref: EMBL:AF139463 xref: EMBL:AL133417 xref: EMBL:BC035625 xref: EMBL:CR749641 xref: EMBL:J04076 xref: EMBL:X53700 xref: HGNC:HGNC:3239 xref: UniGene:Hs.1395 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006070 ! EGR2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004555 name: EHMT1_human def: "Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 gene" [UniProtKB:Q9H9B1] synonym: "EUHMTASE1" EXACT [UniProtKB:Q9H9B1] synonym: "KIAA1876" EXACT [UniProtKB:Q9H9B1] synonym: "KMT1D" EXACT [UniProtKB:Q9H9B1] xref: EMBL:AB028932 xref: EMBL:AB058779 xref: EMBL:AK022941 xref: EMBL:AL713772 xref: EMBL:AY083210 xref: EMBL:BC011608 xref: HGNC:HGNC:24650 xref: UniGene:Hs.495511 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006006 ! EHMT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004556 name: EIF2B3_human def: "Translation initiation factor eIF-2B subunit gamma gene" [UniProtKB:Q9NR50] xref: EMBL:AF257077 xref: EMBL:AK024006 xref: EMBL:AL136380 xref: EMBL:AL834288 xref: EMBL:BC018728 xref: HGNC:HGNC:3259 xref: UniGene:Hs.533549 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005834 ! EI2BG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004557 name: EID1_human def: "EP300-interacting inhibitor of differentiation 1 gene" [UniProtKB:Q9Y6B2] synonym: "C15orf3" EXACT [UniProtKB:Q9Y6B2] synonym: "CRI1" EXACT [UniProtKB:Q9Y6B2] synonym: "PNAS-22" EXACT [UniProtKB:Q9Y6B2] synonym: "PTD014" EXACT [UniProtKB:Q9Y6B2] synonym: "RBP21" EXACT [UniProtKB:Q9Y6B2] xref: EMBL:AF092135 xref: EMBL:AF109873 xref: EMBL:AF274947 xref: EMBL:AF349444 xref: EMBL:AK098383 xref: EMBL:AL109701 xref: EMBL:AL357456 xref: EMBL:BC114944 xref: EMBL:BC114946 xref: HGNC:HGNC:1191 xref: UniGene:Hs.696128 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002263 ! EID1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004558 name: ELF1_human def: "ETS-related transcription factor Elf-1 gene" [UniProtKB:P32519] xref: EMBL:M82882 xref: HGNC:HGNC:3316 xref: UniGene:Hs.135646 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006027 ! ELF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004559 name: ELK1_human def: "ETS domain-containing protein Elk-1 gene" [UniProtKB:P19419] xref: EMBL:AB016193 xref: EMBL:AB016194 xref: EMBL:AF000672 xref: EMBL:AF080616 xref: EMBL:AL009172 xref: EMBL:BC056150 xref: EMBL:M25269 xref: HGNC:HGNC:3321 xref: UniGene:Hs.701980 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005637 ! ELK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004561 name: TCEB2_human def: "Transcription elongation factor B polypeptide 2 gene" [UniProtKB:Q15370] xref: EMBL:AC004493 xref: EMBL:BC013306 xref: EMBL:BC065000 xref: EMBL:L42856 xref: HGNC:HGNC:11619 xref: UniGene:Hs.172772 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005668 ! ELOB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004562 name: TCEB1_human def: "Transcription elongation factor B polypeptide 1 gene" [UniProtKB:Q15369] xref: EMBL:BC013809 xref: EMBL:BC093065 xref: EMBL:BC100028 xref: EMBL:BC100283 xref: EMBL:L34587 xref: HGNC:HGNC:11617 xref: UniGene:Hs.554594 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005667 ! ELOC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004563 name: IKBKAP_human def: "Elongator complex protein 1 gene" [UniProtKB:O95163] synonym: "ELP1" EXACT [UniProtKB:O95163] synonym: "IKAP" EXACT [UniProtKB:O95163] xref: EMBL:AF044195 xref: EMBL:AF153419 xref: EMBL:AL049945 xref: HGNC:HGNC:5959 xref: UniGene:Hs.494738 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005398 ! ELP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004564 name: EML4_human def: "Echinoderm microtubule-associated protein-like 4 gene" [UniProtKB:Q9HC35] synonym: "C2orf2" EXACT [UniProtKB:Q9HC35] synonym: "EMAPL4" EXACT [UniProtKB:Q9HC35] xref: EMBL:AC006038 xref: EMBL:AC083949 xref: EMBL:AC096668 xref: EMBL:AF177377 xref: EMBL:AK001804 xref: EMBL:BC023522 xref: EMBL:BC104647 xref: HGNC:HGNC:1316 xref: UniGene:Hs.593614 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002144 ! EMAL4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004565 name: ENO1_human def: "Alpha-enolase gene" [UniProtKB:P06733] synonym: "ENO1L1" EXACT [UniProtKB:P06733] synonym: "MBPB1" EXACT [UniProtKB:P06733] synonym: "MPB1" EXACT [UniProtKB:P06733] xref: EMBL:AF035286 xref: EMBL:AL139415 xref: EMBL:AL833741 xref: EMBL:BC001810 xref: EMBL:BC004458 xref: EMBL:BC009912 xref: EMBL:BC011130 xref: EMBL:BC015641 xref: EMBL:BC021166 xref: EMBL:BC022545 xref: EMBL:BC027725 xref: EMBL:BC050642 xref: EMBL:BT007163 xref: EMBL:BX537400 xref: EMBL:DQ056744 xref: EMBL:M14328 xref: EMBL:M55914 xref: EMBL:U88968 xref: EMBL:X16288 xref: EMBL:X16289 xref: EMBL:X16290 xref: EMBL:X84907 xref: HGNC:HGNC:3350 xref: UniGene:Hs.517145 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005779 ! ENOA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004566 name: ENO2_human def: "Gamma-enolase gene" [UniProtKB:P09104] xref: EMBL:BC002745 xref: EMBL:BT007383 xref: EMBL:M22349 xref: EMBL:M36768 xref: EMBL:U47924 xref: EMBL:X13120 xref: EMBL:X14327 xref: EMBL:X51956 xref: HGNC:HGNC:3353 xref: UniGene:Hs.511915 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006270 ! ENOG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004567 name: EPS15_human def: "Epidermal growth factor receptor substrate 15 gene" [UniProtKB:P42566] synonym: "AF1P" EXACT [UniProtKB:P42566] xref: EMBL:AC104170 xref: EMBL:AL671986 xref: EMBL:DQ367924 xref: EMBL:U07707 xref: EMBL:Z29064 xref: HGNC:HGNC:3419 xref: UniGene:Hs.83722 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005424 ! EP15_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004568 name: EP300_human def: "Histone acetyltransferase p300 gene" [UniProtKB:Q09472] synonym: "P300" EXACT [UniProtKB:Q09472] xref: EMBL:U01877 xref: HGNC:HGNC:3373 xref: UniGene:Hs.517517 xref: UniGene:Hs.655211 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001728 ! EP300_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004569 name: EP400_human def: "E1A-binding protein p400 gene" [UniProtKB:Q96L91] synonym: "CAGH32" EXACT [UniProtKB:Q96L91] synonym: "KIAA1498" EXACT [UniProtKB:Q96L91] synonym: "KIAA1818" EXACT [UniProtKB:Q96L91] synonym: "TNRC12" EXACT [UniProtKB:Q96L91] xref: EMBL:AB040931 xref: EMBL:AB058721 xref: EMBL:AK096311 xref: EMBL:AY044869 xref: EMBL:BC037208 xref: EMBL:BC064554 xref: EMBL:U80743 xref: HGNC:HGNC:11958 xref: UniGene:Hs.699245 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005916 ! EP400_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004570 name: EPAS1_human def: "Endothelial PAS domain-containing protein 1 gene" [UniProtKB:Q99814] synonym: "HIF2A" EXACT [UniProtKB:Q99814] synonym: "MOP2" EXACT [UniProtKB:Q99814] xref: EMBL:BC051338 xref: EMBL:U51626 xref: EMBL:U81984 xref: HGNC:HGNC:3374 xref: UniGene:Hs.468410 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006077 ! EPAS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004571 name: EPC1_human def: "Enhancer of polycomb homolog 1 gene" [UniProtKB:Q9H2F5] xref: EMBL:AF277374 xref: EMBL:AF286905 xref: EMBL:AK024329 xref: EMBL:AK092304 xref: EMBL:AL158834 xref: EMBL:AL391839 xref: EMBL:BC036529 xref: HGNC:HGNC:19876 xref: UniGene:Hs.167805 xref: UniGene:Hs.633485 xref: UniGene:Hs.654496 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005369 ! EPC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004572 name: EPC2_human def: "Enhancer of polycomb homolog 2 gene" [UniProtKB:Q52LR7] xref: EMBL:AF286904 xref: EMBL:AK001433 xref: EMBL:AK002010 xref: EMBL:AL117558 xref: EMBL:BC093818 xref: EMBL:BC093820 xref: HGNC:HGNC:24543 xref: UniGene:Hs.23270 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005371 ! EPC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004573 name: EPHA2_human def: "Ephrin type-A receptor 2 precursor gene" [UniProtKB:P29317] synonym: "ECK" EXACT [UniProtKB:P29317] xref: EMBL:M59371 xref: HGNC:HGNC:3386 xref: UniGene:Hs.171596 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005832 ! EPHA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004574 name: EPHB2_human def: "Ephrin type-B receptor 2 precursor gene" [UniProtKB:P29323] synonym: "DRT" EXACT [UniProtKB:P29323] synonym: "EPHT3" EXACT [UniProtKB:P29323] synonym: "EPTH3" EXACT [UniProtKB:P29323] synonym: "ERK" EXACT [UniProtKB:P29323] synonym: "HEK5" EXACT [UniProtKB:P29323] synonym: "TYRO5" EXACT [UniProtKB:P29323] xref: EMBL:AF025304 xref: EMBL:AL035704 xref: EMBL:AL158086 xref: EMBL:AL512444 xref: EMBL:D14717 xref: EMBL:D31661 xref: EMBL:D37827 xref: EMBL:L36643 xref: EMBL:L41939 xref: EMBL:X59292 xref: HGNC:HGNC:3393 xref: UniGene:Hs.523329 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001568 ! EPHB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004575 name: EPHB4_human def: "Ephrin type-B receptor 4 precursor gene" [UniProtKB:P54760] synonym: "HTK" EXACT [UniProtKB:P54760] synonym: "TYRO11" EXACT [UniProtKB:P54760] xref: EMBL:AF312032 xref: EMBL:BC004264 xref: EMBL:U07695 xref: HGNC:HGNC:3395 xref: UniGene:Hs.437008 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005833 ! EPHB4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004576 name: EPHB6_human def: "Ephrin type-B receptor 6 precursor gene" [UniProtKB:O15197] xref: EMBL:AF107256 xref: EMBL:AY280502 xref: EMBL:D83492 xref: HGNC:HGNC:3396 xref: UniGene:Hs.380089 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006024 ! EPHB6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004577 name: ERBB2_human def: "Receptor tyrosine-protein kinase erbB-2 precursor gene" [UniProtKB:P04626] synonym: "HER2" EXACT [UniProtKB:P04626] synonym: "NEU" EXACT [UniProtKB:P04626] synonym: "NGL" EXACT [UniProtKB:P04626] xref: EMBL:AY208911 xref: EMBL:L29395 xref: EMBL:M11730 xref: EMBL:M11761 xref: EMBL:M11762 xref: EMBL:M11763 xref: EMBL:M11764 xref: EMBL:M11765 xref: EMBL:M11766 xref: EMBL:M11767 xref: EMBL:M12036 xref: EMBL:M16789 xref: EMBL:M16790 xref: EMBL:M16791 xref: EMBL:M16792 xref: EMBL:M95667 xref: EMBL:X03363 xref: HGNC:HGNC:3430 xref: UniGene:Hs.446352 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005540 ! ERBB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004578 name: ERBB3_human def: "Receptor tyrosine-protein kinase erbB-3 precursor gene" [UniProtKB:P21860] synonym: "HER3" EXACT [UniProtKB:P21860] xref: EMBL:BC082992 xref: EMBL:M29366 xref: EMBL:M34309 xref: EMBL:S61953 xref: HGNC:HGNC:3431 xref: UniGene:Hs.118681 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005852 ! ERBB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004579 name: ERBB4_human def: "Receptor tyrosine-protein kinase erbB-4 precursor gene" [UniProtKB:Q15303] synonym: "HER4" EXACT [UniProtKB:Q15303] xref: EMBL:AB209697 xref: EMBL:BC112199 xref: EMBL:L07868 xref: HGNC:HGNC:3432 xref: UniGene:Hs.390729 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005906 ! ERBB4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004580 name: ERCC5_human def: "DNA-repair protein complementing XP-G cells gene" [UniProtKB:P28715] synonym: "ERCM2" EXACT [UniProtKB:P28715] synonym: "XPG" EXACT [UniProtKB:P28715] synonym: "XPGC" EXACT [UniProtKB:P28715] xref: EMBL:AF255431 xref: EMBL:AF255433 xref: EMBL:AF255434 xref: EMBL:AF255435 xref: EMBL:AF255436 xref: EMBL:AF255437 xref: EMBL:AF255438 xref: EMBL:AF255439 xref: EMBL:AF255440 xref: EMBL:AF255441 xref: EMBL:AF255442 xref: EMBL:AF462447 xref: EMBL:AF550128 xref: EMBL:BC031522 xref: EMBL:D16305 xref: EMBL:L20046 xref: EMBL:X69978 xref: EMBL:X71341 xref: EMBL:X71342 xref: HGNC:HGNC:3437 xref: UniGene:Hs.258429 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006036 ! ERCC5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004581 name: EREG_human def: "Proepiregulin precursor gene" [UniProtKB:O14944] xref: EMBL:CR541887 xref: EMBL:D30783 xref: HGNC:HGNC:3443 xref: UniGene:Hs.115263 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001362 ! EREG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004583 name: C14orf1_human def: "Probable ergosterol biosynthetic protein 28 gene" [UniProtKB:Q9UKR5] synonym: "AD-011" EXACT [UniProtKB:Q9UKR5] synonym: "HSPC288" EXACT [UniProtKB:Q9UKR5] synonym: "x0006" EXACT [UniProtKB:Q9UKR5] xref: EMBL:AC007182 xref: EMBL:AF134159 xref: EMBL:AF136971 xref: EMBL:AF161406 xref: EMBL:AL136658 xref: EMBL:BC002444 xref: HGNC:HGNC:1187 xref: UniGene:Hs.702044 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006287 ! ERG28_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004584 name: ERH_human def: "Enhancer of rudimentary homolog gene" [UniProtKB:P84090] xref: EMBL:BC014301 xref: EMBL:BC071709 xref: EMBL:BT006877 xref: EMBL:CR450298 xref: EMBL:CR542178 xref: EMBL:D85758 xref: EMBL:U66871 xref: HGNC:HGNC:3447 xref: UniGene:Hs.509791 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001703 ! ERH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004585 name: ERN1_human def: "Serine/threonine-protein kinase/endoribonuclease IRE1 precursor gene" [UniProtKB:O75460] synonym: "IRE1" EXACT [UniProtKB:O75460] xref: EMBL:AF059198 xref: HGNC:HGNC:3449 xref: UniGene:Hs.133982 xref: UniGene:Hs.356481 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001428 ! ERN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004587 name: ESCO1_human def: "N-acetyltransferase ESCO1 gene" [UniProtKB:Q5FWF5] synonym: "EFO1" EXACT [UniProtKB:Q5FWF5] synonym: "KIAA1911" EXACT [UniProtKB:Q5FWF5] xref: EMBL:AB067498 xref: EMBL:AK090579 xref: EMBL:AL832041 xref: EMBL:AL834200 xref: EMBL:BC036943 xref: EMBL:BC089426 xref: EMBL:BK001617 xref: HGNC:HGNC:24645 xref: UniGene:Hs.464733 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001848 ! ESCO1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004588 name: ESCO2_human def: "N-acetyltransferase ESCO2 gene" [UniProtKB:Q56NI9] xref: EMBL:AY882862 xref: HGNC:HGNC:27230 xref: UniGene:Hs.99480 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001841 ! ESCO2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004589 name: ESPL1_human def: "Separin gene" [UniProtKB:Q14674] synonym: "ESP1" EXACT [UniProtKB:Q14674] synonym: "KIAA0165" EXACT [UniProtKB:Q14674] xref: EMBL:AY455930 xref: EMBL:D79987 xref: HGNC:HGNC:16856 xref: UniGene:Hs.153479 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001787 ! ESPL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004590 name: ESR1_human def: "Estrogen receptor gene" [UniProtKB:P03372] synonym: "ESR" EXACT [UniProtKB:P03372] synonym: "NR3A1" EXACT [UniProtKB:P03372] xref: EMBL:AF123494 xref: EMBL:AF123495 xref: EMBL:AF123496 xref: EMBL:AF123497 xref: EMBL:AF123498 xref: EMBL:AF123499 xref: EMBL:AF123500 xref: EMBL:AL078582 xref: EMBL:AL356311 xref: EMBL:AL590993 xref: EMBL:AY425004 xref: EMBL:M12674 xref: EMBL:U47678 xref: EMBL:X03635 xref: EMBL:X73067 xref: EMBL:Z75126 xref: HGNC:HGNC:3467 xref: UniGene:Hs.208124 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005652 ! ESR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004591 name: ETHE1_human def: "ETHE1 protein, mitochondrial precursor gene" [UniProtKB:O95571] synonym: "HSCO" EXACT [UniProtKB:O95571] xref: EMBL:AC018758 xref: EMBL:BC008250 xref: EMBL:D83198 xref: HGNC:HGNC:23287 xref: UniGene:Hs.7486 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006189 ! ETHE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004592 name: EVI5_human def: "Ecotropic viral integration site 5 protein homolog gene" [UniProtKB:O60447] synonym: "NB4S" EXACT [UniProtKB:O60447] xref: EMBL:AC104332 xref: EMBL:AC104456 xref: EMBL:AF008915 xref: EMBL:AL133332 xref: EMBL:AL354890 xref: HGNC:HGNC:3501 xref: UniGene:Hs.656836 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001408 ! EVI5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004593 name: EWSR1_human def: "RNA-binding protein EWS gene" [UniProtKB:Q01844] synonym: "EWS" EXACT [UniProtKB:Q01844] xref: EMBL:AB016435 xref: EMBL:BC004817 xref: EMBL:X66899 xref: EMBL:X72990 xref: EMBL:X72991 xref: EMBL:X72992 xref: EMBL:X72993 xref: EMBL:X72994 xref: EMBL:X72995 xref: EMBL:X72996 xref: EMBL:X72997 xref: EMBL:X72998 xref: EMBL:X72999 xref: EMBL:X73000 xref: EMBL:X73001 xref: EMBL:X73002 xref: EMBL:X73003 xref: EMBL:X73004 xref: EMBL:Y07848 xref: EMBL:Y08806 xref: HGNC:HGNC:3508 xref: UniGene:Hs.374477 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005225 ! EWS_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004594 name: EXO1_human def: "Exonuclease 1 gene" [UniProtKB:Q9UQ84] synonym: "EXOI" EXACT [UniProtKB:Q9UQ84] synonym: "HEX1" EXACT [UniProtKB:Q9UQ84] xref: EMBL:AC004783 xref: EMBL:AF042282 xref: EMBL:AF060479 xref: EMBL:AF084974 xref: EMBL:AF091740 xref: EMBL:AF091742 xref: EMBL:AF091743 xref: EMBL:AF091744 xref: EMBL:AF091745 xref: EMBL:AF091746 xref: EMBL:AF091747 xref: EMBL:AF091748 xref: EMBL:AF091749 xref: EMBL:AF091750 xref: EMBL:AF091751 xref: EMBL:AF091752 xref: EMBL:AF091753 xref: EMBL:AF091754 xref: EMBL:AF549168 xref: EMBL:AL080139 xref: EMBL:AL365366 xref: EMBL:BC007491 xref: HGNC:HGNC:3511 xref: UniGene:Hs.498248 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002240 ! EXO1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004595 name: EXOC1_human def: "Exocyst complex component 1 gene" [UniProtKB:Q9NV70] synonym: "BM-012" EXACT [UniProtKB:Q9NV70] synonym: "SEC3" EXACT [UniProtKB:Q9NV70] synonym: "SEC3L1" EXACT [UniProtKB:Q9NV70] xref: EMBL:AF208854 xref: EMBL:AK001755 xref: EMBL:AK027413 xref: EMBL:BC020650 xref: EMBL:BC094751 xref: HGNC:HGNC:30380 xref: UniGene:Hs.269665 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005592 ! EXOC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004596 name: EXOC8_human def: "Exocyst complex component 8 gene" [UniProtKB:Q8IYI6] xref: EMBL:AL117352 xref: EMBL:BC035763 xref: HGNC:HGNC:24659 xref: UniGene:Hs.356198 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005255 ! EXOC8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004597 name: EXOSC3_human def: "Exosome complex exonuclease RRP40 gene" [UniProtKB:Q9NQT5] synonym: "CGI-102" EXACT [UniProtKB:Q9NQT5] synonym: "RRP40" EXACT [UniProtKB:Q9NQT5] xref: EMBL:AF151860 xref: EMBL:AF281132 xref: EMBL:BC002437 xref: EMBL:BC008880 xref: HGNC:HGNC:17944 xref: UniGene:Hs.591076 xref: UniGene:Hs.602571 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005557 ! EXOS3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004598 name: EXOSC4_human def: "Exosome complex exonuclease RRP41 gene" [UniProtKB:Q9NPD3] synonym: "RRP41" EXACT [UniProtKB:Q9NPD3] synonym: "SKI6" EXACT [UniProtKB:Q9NPD3] xref: EMBL:AF281133 xref: EMBL:AK000598 xref: EMBL:BC002777 xref: HGNC:HGNC:18189 xref: UniGene:Hs.632041 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005554 ! EXOS4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004599 name: EXOSC5_human def: "Exosome complex exonuclease RRP46 gene" [UniProtKB:Q9NQT4] synonym: "CML28" EXACT [UniProtKB:Q9NQT4] synonym: "RRP46" EXACT [UniProtKB:Q9NQT4] xref: EMBL:AF281134 xref: EMBL:AF285785 xref: EMBL:BC007742 xref: EMBL:BC107696 xref: HGNC:HGNC:24662 xref: UniGene:Hs.283741 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005555 ! EXOS5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004600 name: EXOSC8_human def: "Exosome complex exonuclease RRP43 gene" [UniProtKB:Q96B26] synonym: "OIP2" EXACT [UniProtKB:Q96B26] synonym: "RRP43" EXACT [UniProtKB:Q96B26] xref: EMBL:AF025438 xref: EMBL:BC020773 xref: HGNC:HGNC:17035 xref: UniGene:Hs.294041 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005556 ! EXOS8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004601 name: EXOSC10_human def: "Exosome component 10 gene" [UniProtKB:Q01780] synonym: "PMSCL" EXACT [UniProtKB:Q01780] synonym: "PMSCL2" EXACT [UniProtKB:Q01780] xref: EMBL:AJ300188 xref: EMBL:BC039901 xref: EMBL:BC073788 xref: EMBL:L01457 xref: EMBL:X66113 xref: HGNC:HGNC:9138 xref: UniGene:Hs.632368 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005348 ! EXOSX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004602 name: EXT1_human def: "Exostosin-1 gene" [UniProtKB:Q16394] xref: EMBL:BC001174 xref: EMBL:S79639 xref: EMBL:U70539 xref: HGNC:HGNC:3512 xref: UniGene:Hs.492618 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001818 ! EXT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004603 name: EXT2_human def: "Exostosin-2 gene" [UniProtKB:Q93063] xref: EMBL:BC010058 xref: EMBL:U62740 xref: EMBL:U64511 xref: EMBL:U67356 xref: EMBL:U67357 xref: EMBL:U67358 xref: EMBL:U67360 xref: EMBL:U67361 xref: EMBL:U67362 xref: EMBL:U67363 xref: EMBL:U67364 xref: EMBL:U67365 xref: EMBL:U67366 xref: EMBL:U67367 xref: EMBL:U67368 xref: EMBL:U72263 xref: HGNC:HGNC:3513 xref: UniGene:Hs.368404 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002028 ! EXT2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004604 name: FAM131C_human def: "Protein FAM131C gene" [UniProtKB:Q96AQ9] synonym: "C1orf117" EXACT [UniProtKB:Q96AQ9] xref: EMBL:AK094085 xref: EMBL:AL355994 xref: EMBL:BC016848 xref: EMBL:BC037394 xref: HGNC:HGNC:26717 xref: UniGene:Hs.126825 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005290 ! F131C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004605 name: FANCD2_human def: "Fanconi anemia group D2 protein gene" [UniProtKB:Q9BXW9] synonym: "FACD" EXACT [UniProtKB:Q9BXW9] xref: EMBL:AF230336 xref: EMBL:AF273222 xref: EMBL:AF273223 xref: EMBL:AF273224 xref: EMBL:AF273225 xref: EMBL:AF273226 xref: EMBL:AF273227 xref: EMBL:AF273228 xref: EMBL:AF273229 xref: EMBL:AF273230 xref: EMBL:AF273231 xref: EMBL:AF273232 xref: EMBL:AF273233 xref: EMBL:AF273234 xref: EMBL:AF273235 xref: EMBL:AF273236 xref: EMBL:AF273237 xref: EMBL:AF273238 xref: EMBL:AF273239 xref: EMBL:AF273240 xref: EMBL:AF273241 xref: EMBL:AF273242 xref: EMBL:AF273243 xref: EMBL:AF273244 xref: EMBL:AF273245 xref: EMBL:AF273246 xref: EMBL:AF273247 xref: EMBL:AF273248 xref: EMBL:AF273249 xref: EMBL:AF273250 xref: EMBL:AF273251 xref: EMBL:AF340183 xref: EMBL:AK022613 xref: EMBL:AL832427 xref: EMBL:BC013582 xref: EMBL:DQ341263 xref: HGNC:HGNC:3585 xref: UniGene:Hs.208388 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002109 ! FACD2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004606 name: PTK2_human def: "Focal adhesion kinase 1 gene" [UniProtKB:Q05397] synonym: "FAK" EXACT [UniProtKB:Q05397] synonym: "FAK1" EXACT [UniProtKB:Q05397] xref: EMBL:L05186 xref: EMBL:L13616 xref: HGNC:HGNC:9611 xref: UniGene:Hs.395482 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005812 ! FAK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004607 name: PTK2B_human def: "Protein tyrosine kinase 2 beta gene" [UniProtKB:Q14289] synonym: "FAK2" EXACT [UniProtKB:Q14289] synonym: "PYK2" EXACT [UniProtKB:Q14289] synonym: "RAFTK" EXACT [UniProtKB:Q14289] xref: EMBL:AF311103 xref: EMBL:BC042599 xref: EMBL:D45853 xref: EMBL:L49207 xref: EMBL:S80542 xref: EMBL:U33284 xref: EMBL:U43522 xref: HGNC:HGNC:9612 xref: UniGene:Hs.491322 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005846 ! FAK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004608 name: FANCA_human def: "Fanconi anemia group A protein gene" [UniProtKB:O15360] synonym: "FAA" EXACT [UniProtKB:O15360] synonym: "FACA" EXACT [UniProtKB:O15360] synonym: "FANCH" EXACT [UniProtKB:O15360] xref: EMBL:AC005360 xref: EMBL:AC005565 xref: EMBL:AC005567 xref: EMBL:AC092385 xref: EMBL:AF054569 xref: EMBL:AJ225084 xref: EMBL:AJ225085 xref: EMBL:AY598423 xref: EMBL:BC008979 xref: EMBL:X99226 xref: EMBL:Z83067 xref: EMBL:Z83068 xref: EMBL:Z83069 xref: EMBL:Z83070 xref: EMBL:Z83071 xref: EMBL:Z83072 xref: EMBL:Z83073 xref: EMBL:Z83074 xref: EMBL:Z83075 xref: EMBL:Z83076 xref: EMBL:Z83077 xref: EMBL:Z83078 xref: EMBL:Z83079 xref: EMBL:Z83080 xref: EMBL:Z83081 xref: EMBL:Z83082 xref: EMBL:Z83083 xref: EMBL:Z83084 xref: EMBL:Z83085 xref: EMBL:Z83086 xref: EMBL:Z83087 xref: EMBL:Z83088 xref: EMBL:Z83089 xref: EMBL:Z83090 xref: EMBL:Z83091 xref: EMBL:Z83092 xref: EMBL:Z83093 xref: EMBL:Z83094 xref: EMBL:Z83095 xref: EMBL:Z83151 xref: HGNC:HGNC:3582 xref: UniGene:Hs.567267 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005323 ! FANCA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004609 name: FANCE_human def: "Fanconi anemia group E protein gene" [UniProtKB:Q9HB96] synonym: "FACE" EXACT [UniProtKB:Q9HB96] xref: EMBL:AF265210 xref: EMBL:AL022721 xref: EMBL:BC046359 xref: EMBL:DQ020173 xref: HGNC:HGNC:3586 xref: UniGene:Hs.302003 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005576 ! FANCE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004610 name: FANCF_human def: "Fanconi anemia group F protein gene" [UniProtKB:Q9NPI8] xref: EMBL:AF181994 xref: EMBL:AF181995 xref: EMBL:AK023153 xref: EMBL:AY928335 xref: EMBL:BC047028 xref: EMBL:BC093867 xref: EMBL:BC101807 xref: HGNC:HGNC:3587 xref: UniGene:Hs.632151 xref: UniGene:Hs.702150 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005936 ! FANCF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004611 name: FANCG_human def: "Fanconi anemia group G protein gene" [UniProtKB:O15287] synonym: "XRCC9" EXACT [UniProtKB:O15287] xref: EMBL:AC004472 xref: EMBL:AJ007669 xref: EMBL:AL353795 xref: EMBL:AY795970 xref: EMBL:BC000032 xref: EMBL:BC011623 xref: EMBL:U70310 xref: HGNC:HGNC:3588 xref: UniGene:Hs.591084 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001370 ! FANCG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004612 name: FANCI_human def: "Fanconi anemia group I protein gene" [UniProtKB:Q9NVI1] synonym: "KIAA1794" EXACT [UniProtKB:Q9NVI1] xref: EMBL:AB058697 xref: EMBL:AK001581 xref: EMBL:AK027564 xref: EMBL:BC004277 xref: HGNC:HGNC:25568 xref: UniGene:Hs.513126 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002170 ! FANCI_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004613 name: BRIP1_human def: "Fanconi anemia group J protein gene" [UniProtKB:Q9BX63] synonym: "BACH1" EXACT [UniProtKB:Q9BX63] synonym: "FANCJ" EXACT [UniProtKB:Q9BX63] xref: EMBL:AF360549 xref: EMBL:AK074713 xref: EMBL:BC101472 xref: EMBL:BC101474 xref: HGNC:HGNC:20473 xref: UniGene:Hs.532799 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002107 ! FANCJ_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004614 name: FBLN1_human def: "Fibulin-1 precursor gene" [UniProtKB:P23142] synonym: "PP213" EXACT [UniProtKB:P23142] xref: EMBL:AF126110 xref: EMBL:AF217999 xref: EMBL:AL021391 xref: EMBL:AY040589 xref: EMBL:BC022497 xref: EMBL:U01244 xref: EMBL:X53741 xref: EMBL:X53742 xref: EMBL:X53743 xref: EMBL:Z95331 xref: EMBL:Z98047 xref: HGNC:HGNC:3600 xref: UniGene:Hs.24601 xref: UniGene:Hs.593123 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005959 ! FBLN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004615 name: EFEMP1_human def: "EGF-containing fibulin-like extracellular matrix protein 1 precursor gene" [UniProtKB:Q12805] synonym: "FBLN3" EXACT [UniProtKB:Q12805] synonym: "FBNL" EXACT [UniProtKB:Q12805] xref: EMBL:AY004321 xref: EMBL:AY004322 xref: EMBL:AY004323 xref: EMBL:AY004324 xref: EMBL:AY004325 xref: EMBL:AY004326 xref: EMBL:AY004327 xref: EMBL:AY004328 xref: EMBL:AY004329 xref: EMBL:AY004330 xref: EMBL:BC014410 xref: EMBL:BC098561 xref: EMBL:U03877 xref: HGNC:HGNC:3218 xref: UniGene:Hs.76224 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005955 ! FBLN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004616 name: EFEMP2_human def: "EGF-containing fibulin-like extracellular matrix protein 2 precursor gene" [UniProtKB:O95967] synonym: "FBLN4" EXACT [UniProtKB:O95967] synonym: "UNQ200/PRO226" EXACT [UniProtKB:O95967] xref: EMBL:AF093119 xref: EMBL:AF109121 xref: EMBL:AJ132819 xref: EMBL:AP001201 xref: EMBL:AY358899 xref: EMBL:BC010456 xref: HGNC:HGNC:3219 xref: UniGene:Hs.647231 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005215 ! FBLN4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004617 name: FBLN5_human def: "Fibulin-5 precursor gene" [UniProtKB:Q9UBX5] synonym: "DANCE" EXACT [UniProtKB:Q9UBX5] synonym: "UNQ184/PRO210" EXACT [UniProtKB:Q9UBX5] xref: EMBL:AF093118 xref: EMBL:AF112152 xref: EMBL:AJ133490 xref: EMBL:AY358898 xref: EMBL:BC022280 xref: HGNC:HGNC:3602 xref: UniGene:Hs.332708 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005989 ! FBLN5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004619 name: BTRC_human def: "F-box/WD repeat-containing protein 1A gene" [UniProtKB:Q9Y297] synonym: "BTRCP" EXACT [UniProtKB:Q9Y297] synonym: "FBW1A" EXACT [UniProtKB:Q9Y297] synonym: "FBXW1A" EXACT [UniProtKB:Q9Y297] xref: EMBL:AF101784 xref: EMBL:AF129530 xref: EMBL:BC027994 xref: EMBL:Y14153 xref: HGNC:HGNC:1144 xref: UniGene:Hs.696242 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005633 ! FBW1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004620 name: FBXW11_human def: "F-box/WD repeat-containing protein 11 gene" [UniProtKB:Q9UKB1] synonym: "BTRCP2" EXACT [UniProtKB:Q9UKB1] synonym: "FBW1B" EXACT [UniProtKB:Q9UKB1] synonym: "FBXW1B" EXACT [UniProtKB:Q9UKB1] synonym: "KIAA0696" EXACT [UniProtKB:Q9UKB1] xref: EMBL:AB014596 xref: EMBL:AB033279 xref: EMBL:AB033280 xref: EMBL:AB033281 xref: EMBL:AF176022 xref: EMBL:BC026213 xref: HGNC:HGNC:13607 xref: UniGene:Hs.484138 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005941 ! FBW1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004621 name: FBXO11_human def: "F-box only protein 11 gene" [UniProtKB:Q86XK2] synonym: "FBX11" EXACT [UniProtKB:Q86XK2] synonym: "VIT1" EXACT [UniProtKB:Q86XK2] xref: EMBL:AF174599 xref: EMBL:AF176706 xref: EMBL:AF264714 xref: EMBL:AF351618 xref: EMBL:AK022735 xref: EMBL:AK025477 xref: EMBL:AK223592 xref: EMBL:AL117620 xref: EMBL:AY827075 xref: EMBL:BC012728 xref: EMBL:BC043258 xref: HGNC:HGNC:13590 xref: UniGene:Hs.352677 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005332 ! FBX11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004622 name: FBXO18_human def: "F-box only protein 18 gene" [UniProtKB:Q8NFZ0] synonym: "FBH1" EXACT [UniProtKB:Q8NFZ0] synonym: "FBX18" EXACT [UniProtKB:Q8NFZ0] xref: EMBL:AF380349 xref: EMBL:AF454502 xref: EMBL:AF456237 xref: EMBL:AK027381 xref: EMBL:AK027496 xref: EMBL:AK095343 xref: EMBL:AL133069 xref: EMBL:AL137186 xref: EMBL:BC012762 xref: EMBL:BC032674 xref: EMBL:BC113377 xref: HGNC:HGNC:13620 xref: UniGene:Hs.498543 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006328 ! FBX18_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004623 name: FBXO25_human def: "F-box only protein 25 gene" [UniProtKB:Q8TCJ0] synonym: "FBX25" EXACT [UniProtKB:Q8TCJ0] xref: EMBL:AB070270 xref: EMBL:AF174605 xref: EMBL:AF419858 xref: EMBL:BC020249 xref: EMBL:BC050393 xref: HGNC:HGNC:13596 xref: UniGene:Hs.438454 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005440 ! FBX25_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004624 name: FBXO43_human def: "F-box only protein 43 gene" [UniProtKB:Q4G163] synonym: "EMI2" EXACT [UniProtKB:Q4G163] xref: EMBL:AC021590 xref: HGNC:HGNC:28521 xref: UniGene:Hs.339577 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001835 ! FBX43_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004625 name: FBXO4_human def: "F-box only protein 4 gene" [UniProtKB:Q9UKT5] synonym: "FBX4" EXACT [UniProtKB:Q9UKT5] xref: EMBL:AF129534 xref: EMBL:AF176703 xref: EMBL:BC048098 xref: EMBL:CR749719 xref: HGNC:HGNC:13583 xref: UniGene:Hs.165575 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005441 ! FBX4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004626 name: FBXO5_human def: "F-box only protein 5 gene" [UniProtKB:Q9UKT4] synonym: "EMI1" EXACT [UniProtKB:Q9UKT4] synonym: "FBX5" EXACT [UniProtKB:Q9UKT4] xref: EMBL:AF129535 xref: EMBL:AL080276 xref: EMBL:AY079515 xref: EMBL:BC018905 xref: HGNC:HGNC:13584 xref: UniGene:Hs.705509 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002221 ! FBX5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004627 name: FBXO7_human def: "F-box only protein 7 gene" [UniProtKB:Q9Y3I1] synonym: "FBX7" EXACT [UniProtKB:Q9Y3I1] xref: EMBL:AF129537 xref: EMBL:AF233225 xref: EMBL:AL021937 xref: EMBL:AL035068 xref: EMBL:AL050254 xref: EMBL:BC008361 xref: EMBL:CR456491 xref: EMBL:Z71183 xref: HGNC:HGNC:13586 xref: UniGene:Hs.5912 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005442 ! FBX7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004628 name: FBXW7_human def: "F-box/WD repeat-containing protein 7 gene" [UniProtKB:Q969H0] synonym: "FBW7" EXACT [UniProtKB:Q969H0] synonym: "FBX30" EXACT [UniProtKB:Q969H0] synonym: "SEL10" EXACT [UniProtKB:Q969H0] xref: EMBL:AF383178 xref: EMBL:AF411971 xref: EMBL:AF411972 xref: EMBL:AK001933 xref: EMBL:AY008274 xref: EMBL:AY033553 xref: EMBL:AY049984 xref: EMBL:BC037320 xref: EMBL:BC117244 xref: EMBL:BC117246 xref: EMBL:CR749305 xref: HGNC:HGNC:16712 xref: UniGene:Hs.696040 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005654 ! FBXW7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004629 name: FEZ1_human def: "Fasciculation and elongation protein zeta-1 gene" [UniProtKB:Q99689] xref: EMBL:BC009545 xref: EMBL:CR456817 xref: EMBL:CR541954 xref: EMBL:U60060 xref: EMBL:U60062 xref: EMBL:U69139 xref: HGNC:HGNC:3659 xref: UniGene:Hs.224008 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005393 ! FEZ1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004630 name: FEZ2_human def: "Fasciculation and elongation protein zeta-2 gene" [UniProtKB:Q9UHY8] xref: EMBL:AB076184 xref: EMBL:AC007401 xref: EMBL:AF113124 xref: EMBL:U60061 xref: EMBL:U69140 xref: HGNC:HGNC:3660 xref: UniGene:Hs.258563 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005394 ! FEZ2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004644 name: FGFR3_human def: "Fibroblast growth factor receptor 3 precursor gene" [UniProtKB:P22607] synonym: "JTK4" EXACT [UniProtKB:P22607] xref: EMBL:AF245114 xref: EMBL:AY768549 xref: EMBL:M58051 xref: EMBL:M59374 xref: EMBL:M64347 xref: EMBL:S76733 xref: EMBL:U22410 xref: EMBL:X84939 xref: HGNC:HGNC:3690 xref: UniGene:Hs.1420 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005920 ! FGFR3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004645 name: FHIT_human def: "Bis(5'-adenosyl)-triphosphatase gene" [UniProtKB:P49789] xref: EMBL:AY625256 xref: EMBL:BC032336 xref: EMBL:U46922 xref: EMBL:U76267 xref: EMBL:U76268 xref: EMBL:U76269 xref: EMBL:U76270 xref: EMBL:U76271 xref: HGNC:HGNC:3701 xref: UniGene:Hs.655995 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001636 ! FHIT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004646 name: FHL2_human def: "Four and a half LIM domains protein 2 gene" [UniProtKB:Q14192] synonym: "DRAL" EXACT [UniProtKB:Q14192] synonym: "SLIM3" EXACT [UniProtKB:Q14192] xref: EMBL:AB038794 xref: EMBL:BC014397 xref: EMBL:L42176 xref: EMBL:U29332 xref: EMBL:U60117 xref: HGNC:HGNC:3703 xref: UniGene:Hs.443687 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005830 ! FHL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004648 name: FKBP6_human def: "FK506-binding protein 6 gene" [UniProtKB:O75344] synonym: "FKBP36" EXACT [UniProtKB:O75344] xref: EMBL:AF038847 xref: EMBL:BC036817 xref: HGNC:HGNC:3722 xref: UniGene:Hs.661266 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005219 ! FKBP6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004649 name: WTAP_human def: "Pre-mRNA-splicing regulator WTAP gene" [UniProtKB:Q15007] synonym: "KIAA0105" EXACT [UniProtKB:Q15007] xref: EMBL:AF374416 xref: EMBL:AJ276706 xref: EMBL:AL135914 xref: EMBL:AL583911 xref: EMBL:BC000383 xref: EMBL:BC004432 xref: EMBL:BC069192 xref: EMBL:CH471051 xref: EMBL:D14661 xref: HGNC:HGNC:16846 xref: UniGene:Hs.446091 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001798 ! FL2D_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004650 name: FLCN_human def: "Folliculin gene" [UniProtKB:Q8NFG4] synonym: "BHD" EXACT [UniProtKB:Q8NFG4] xref: EMBL:AC055811 xref: EMBL:AF517523 xref: EMBL:AK126951 xref: EMBL:AK127912 xref: EMBL:BC015687 xref: EMBL:BC015725 xref: EMBL:CH471196 xref: HGNC:HGNC:27310 xref: UniGene:Hs.513975 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001981 ! FLCN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004651 name: FNBP1_human def: "Formin-binding protein 1 gene" [UniProtKB:Q96RU3] synonym: "FBP17" EXACT [UniProtKB:Q96RU3] synonym: "KIAA0554" EXACT [UniProtKB:Q96RU3] xref: EMBL:AB011126 xref: EMBL:AF265550 xref: EMBL:AK000975 xref: EMBL:AK023681 xref: EMBL:AL136141 xref: EMBL:AL158207 xref: EMBL:BC062463 xref: EMBL:BC101755 xref: HGNC:HGNC:17069 xref: UniGene:Hs.189409 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005386 ! FNBP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004654 name: FOXC1_human def: "Forkhead box protein C1 gene" [UniProtKB:Q12948] synonym: "FKHL7" EXACT [UniProtKB:Q12948] synonym: "FREAC3" EXACT [UniProtKB:Q12948] xref: EMBL:AF048693 xref: EMBL:AF078096 xref: EMBL:AL034344 xref: EMBL:AY228704 xref: EMBL:L12143 xref: EMBL:U13221 xref: HGNC:HGNC:3800 xref: UniGene:Hs.348883 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001735 ! FOXC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004655 name: FOXN3_human def: "Forkhead box protein N3 gene" [UniProtKB:O00409] synonym: "C14orf116" EXACT [UniProtKB:O00409] synonym: "CHES1" EXACT [UniProtKB:O00409] xref: EMBL:AC007263 xref: EMBL:AL138478 xref: EMBL:AL356805 xref: EMBL:AL357093 xref: EMBL:BC007506 xref: EMBL:U68723 xref: HGNC:HGNC:1928 xref: UniGene:Hs.434286 xref: UniGene:Hs.621371 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001347 ! FOXN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004656 name: FOXO4_human def: "Forkhead box protein O4 gene" [UniProtKB:P98177] synonym: "AFX" EXACT [UniProtKB:P98177] synonym: "AFX1" EXACT [UniProtKB:P98177] synonym: "MLLT7" EXACT [UniProtKB:P98177] xref: EMBL:AF384029 xref: EMBL:BC106761 xref: EMBL:U10072 xref: EMBL:X93996 xref: EMBL:Y11284 xref: EMBL:Y11285 xref: EMBL:Y11286 xref: HGNC:HGNC:7139 xref: UniGene:Hs.584654 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001706 ! FOXO4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004658 name: FTL_human def: "Ferritin light chain gene" [UniProtKB:P02792] xref: EMBL:BC002991 xref: EMBL:BC004245 xref: EMBL:BC008439 xref: EMBL:BC016346 xref: EMBL:BC016354 xref: EMBL:BC018990 xref: EMBL:BC058820 xref: EMBL:BC062708 xref: EMBL:BX571748 xref: EMBL:M10119 xref: EMBL:M11147 xref: EMBL:M12938 xref: EMBL:X03742 xref: EMBL:X03743 xref: HGNC:HGNC:3999 xref: UniGene:Hs.433670 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006192 ! FRIL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004660 name: FRMD6_human def: "FERM domain-containing protein 6 gene" [UniProtKB:Q96NE9] synonym: "C14orf31" EXACT [UniProtKB:Q96NE9] xref: EMBL:AK055545 xref: EMBL:AL079307 xref: EMBL:BC020521 xref: EMBL:BC029870 xref: EMBL:BX161430 xref: EMBL:BX647863 xref: HGNC:HGNC:19839 xref: UniGene:Hs.434914 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005267 ! FRMD6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004663 name: FH_human def: "Fumarate hydratase, mitochondrial precursor gene" [UniProtKB:P07954] xref: EMBL:BC003108 xref: EMBL:BC017444 xref: EMBL:BT009839 xref: EMBL:M15502 xref: EMBL:U48857 xref: EMBL:U59309 xref: HGNC:HGNC:3700 xref: UniGene:Hs.592490 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001496 ! FUMH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004664 name: FXR1_human def: "Fragile X mental retardation syndrome-related protein 1 gene" [UniProtKB:P51114] xref: EMBL:AY341428 xref: EMBL:BC028983 xref: EMBL:U25165 xref: HGNC:HGNC:4023 xref: UniGene:Hs.478407 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006140 ! FXR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004665 name: FXYD6_human def: "FXYD domain-containing ion transport regulator 6 precursor gene" [UniProtKB:Q9H0Q3] synonym: "UNQ521/PRO1056" EXACT [UniProtKB:Q9H0Q3] xref: EMBL:AL136699 xref: EMBL:AL832811 xref: EMBL:AY358976 xref: EMBL:BC018652 xref: EMBL:BC093040 xref: EMBL:BT006717 xref: EMBL:CR533457 xref: HGNC:HGNC:4030 xref: UniGene:Hs.635508 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006141 ! FXYD6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004666 name: FYN_human def: "Proto-oncogene tyrosine-protein kinase Fyn gene" [UniProtKB:P06241] xref: EMBL:BC032496 xref: EMBL:M14333 xref: EMBL:M14676 xref: EMBL:S74774 xref: EMBL:Z97989 xref: HGNC:HGNC:4037 xref: UniGene:Hs.390567 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005609 ! FYN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004667 name: FZR1_human def: "Fizzy-related protein homolog gene" [UniProtKB:Q9UM11] synonym: "CDH1" EXACT [UniProtKB:Q9UM11] synonym: "FYR" EXACT [UniProtKB:Q9UM11] synonym: "FZR" EXACT [UniProtKB:Q9UM11] synonym: "KIAA1242" EXACT [UniProtKB:Q9UM11] xref: EMBL:AB013462 xref: EMBL:AB013463 xref: EMBL:AB033068 xref: EMBL:AC005786 xref: EMBL:AC005787 xref: EMBL:AF080397 xref: EMBL:AF083810 xref: EMBL:AF102507 xref: EMBL:AF102508 xref: EMBL:AF433157 xref: EMBL:BC013413 xref: EMBL:BT007115 xref: HGNC:HGNC:24824 xref: UniGene:Hs.413133 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002229 ! FZR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004668 name: G0S2_human def: "Putative lymphocyte G0/G1 switch protein 2 gene" [UniProtKB:P27469] xref: EMBL:AL031316 xref: EMBL:BC009694 xref: EMBL:M69199 xref: EMBL:M72885 xref: HGNC:HGNC:30229 xref: UniGene:Hs.432132 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001561 ! G0S2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004669 name: GAPDH_human def: "Glyceraldehyde-3-phosphate dehydrogenase gene" [UniProtKB:P04406] synonym: "CDABP0047" EXACT [UniProtKB:P04406] synonym: "GAPD" EXACT [UniProtKB:P04406] synonym: "OK/SW-cl.12" EXACT [UniProtKB:P04406] xref: EMBL:AB062273 xref: EMBL:AF261085 xref: EMBL:AY007133 xref: EMBL:AY340484 xref: EMBL:BC001601 xref: EMBL:BC004109 xref: EMBL:BC009081 xref: EMBL:BC013310 xref: EMBL:BC023632 xref: EMBL:BC025925 xref: EMBL:BC026907 xref: EMBL:BC029618 xref: EMBL:BC083511 xref: EMBL:BT006893 xref: EMBL:J02642 xref: EMBL:J04038 xref: EMBL:M17851 xref: EMBL:M33197 xref: EMBL:X01677 xref: EMBL:X53778 xref: HGNC:HGNC:4141 xref: UniGene:Hs.479728 xref: UniGene:Hs.544577 xref: UniGene:Hs.592355 xref: UniGene:Hs.648900 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005458 ! G3P_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004670 name: GADD45GIP1_human def: "Growth arrest and DNA-damage-inducible proteins-interacting protein 1 gene" [UniProtKB:Q8TAE8] synonym: "PLINP1" EXACT [UniProtKB:Q8TAE8] synonym: "PRG6" EXACT [UniProtKB:Q8TAE8] xref: EMBL:AF147080 xref: EMBL:AF475095 xref: EMBL:AF479749 xref: EMBL:AJ295986 xref: EMBL:AJ429498 xref: EMBL:BC004944 xref: EMBL:BC013027 xref: EMBL:BC013039 xref: EMBL:BC069200 xref: HGNC:HGNC:29996 xref: UniGene:Hs.515164 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001987 ! G45IP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004671 name: GAS2L1_human def: "GAS2-like protein 1 gene" [UniProtKB:Q99501] synonym: "GAR22" EXACT [UniProtKB:Q99501] xref: EMBL:AK223602 xref: EMBL:BC001782 xref: EMBL:BC007624 xref: EMBL:BC011047 xref: EMBL:Y07846 xref: EMBL:Y07848 xref: HGNC:HGNC:16955 xref: UniGene:Hs.322852 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002067 ! GA2L1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004672 name: GAS2L2_human def: "GAS2-like protein 2 gene" [UniProtKB:Q8NHY3] synonym: "GAR17" EXACT [UniProtKB:Q8NHY3] xref: EMBL:AF508784 xref: EMBL:AF508785 xref: HGNC:HGNC:24846 xref: UniGene:Hs.591194 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001985 ! GA2L2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004673 name: GAS2L3_human def: "GAS2-like protein 3 gene" [UniProtKB:Q86XJ1] xref: EMBL:BC043366 xref: HGNC:HGNC:27475 xref: UniGene:Hs.20575 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001944 ! GA2L3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004674 name: GADD45A_human def: "Growth arrest and DNA-damage-inducible protein GADD45 alpha gene" [UniProtKB:P24522] synonym: "DDIT1" EXACT [UniProtKB:P24522] synonym: "GADD45" EXACT [UniProtKB:P24522] xref: EMBL:AY135686 xref: EMBL:BC011757 xref: EMBL:L24498 xref: EMBL:M60974 xref: HGNC:HGNC:4095 xref: UniGene:Hs.80409 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001552 ! GA45A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004675 name: GADD45B_human def: "Growth arrest and DNA-damage-inducible protein GADD45 beta gene" [UniProtKB:O75293] synonym: "MYD118" EXACT [UniProtKB:O75293] xref: EMBL:AC005624 xref: EMBL:AF078077 xref: EMBL:AF087853 xref: EMBL:AF090950 xref: EMBL:AF533019 xref: EMBL:BC113466 xref: EMBL:BC117469 xref: HGNC:HGNC:4096 xref: UniGene:Hs.110571 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001424 ! GA45B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004676 name: GADD45G_human def: "Growth arrest and DNA-damage-inducible protein GADD45 gamma gene" [UniProtKB:O95257] synonym: "CR6" EXACT [UniProtKB:O95257] synonym: "DDIT2" EXACT [UniProtKB:O95257] xref: EMBL:AF078078 xref: EMBL:AF079806 xref: EMBL:AF087883 xref: EMBL:AF265659 xref: EMBL:AF494037 xref: EMBL:BC000465 xref: EMBL:BC019325 xref: EMBL:BT007234 xref: HGNC:HGNC:4097 xref: UniGene:Hs.9701 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005411 ! GA45G_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004677 name: GAB2_human def: "GRB2-associated-binding protein 2 gene" [UniProtKB:Q9UQC2] synonym: "KIAA0571" EXACT [UniProtKB:Q9UQC2] xref: EMBL:AB011143 xref: EMBL:AB018413 xref: HGNC:HGNC:14458 xref: UniGene:Hs.429434 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005924 ! GAB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004679 name: GABPA_human def: "GA-binding protein alpha chain gene" [UniProtKB:Q06546] synonym: "E4TF1A" EXACT [UniProtKB:Q06546] xref: EMBL:D13318 xref: EMBL:U13044 xref: HGNC:HGNC:4071 xref: UniGene:Hs.246310 xref: UniGene:Hs.473470 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005878 ! GABPA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004680 name: GABBR1_human def: "Gamma-aminobutyric acid type B receptor subunit 1 precursor gene" [UniProtKB:Q9UBS5] synonym: "GPRC3A" EXACT [UniProtKB:Q9UBS5] xref: EMBL:AF099148 xref: EMBL:AJ010170 xref: EMBL:AJ010171 xref: EMBL:AJ010172 xref: EMBL:AJ010173 xref: EMBL:AJ010174 xref: EMBL:AJ010175 xref: EMBL:AJ010176 xref: EMBL:AJ010177 xref: EMBL:AJ010178 xref: EMBL:AJ010179 xref: EMBL:AJ010180 xref: EMBL:AJ010181 xref: EMBL:AJ010182 xref: EMBL:AJ010183 xref: EMBL:AJ010184 xref: EMBL:AJ010185 xref: EMBL:AJ010186 xref: EMBL:AJ010187 xref: EMBL:AJ010188 xref: EMBL:AJ010189 xref: EMBL:AJ010190 xref: EMBL:AJ010191 xref: EMBL:AJ012185 xref: EMBL:AJ012186 xref: EMBL:AJ012187 xref: EMBL:AJ012288 xref: EMBL:AJ225028 xref: EMBL:AJ225029 xref: EMBL:AL031983 xref: EMBL:BC042598 xref: EMBL:BC050532 xref: EMBL:Y11044 xref: HGNC:HGNC:4070 xref: UniGene:Hs.167017 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006317 ! GABR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004681 name: GAK_human def: "Cyclin G-associated kinase gene" [UniProtKB:O14976] xref: EMBL:BC000816 xref: EMBL:BC008668 xref: EMBL:D88435 xref: HGNC:HGNC:4113 xref: UniGene:Hs.369607 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001364 ! GAK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004682 name: GAS1_human def: "Growth arrest-specific protein 1 precursor gene" [UniProtKB:P54826] xref: EMBL:L13698 xref: HGNC:HGNC:4165 xref: UniGene:Hs.65029 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001672 ! GAS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004683 name: GAS2_human def: "Growth arrest-specific protein 2 gene" [UniProtKB:O43903] xref: EMBL:BC040470 xref: EMBL:CR450285 xref: EMBL:U95032 xref: HGNC:HGNC:4167 xref: UniGene:Hs.702150 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001401 ! GAS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004684 name: GAS7_human def: "Growth arrest-specific protein 7 gene" [UniProtKB:O60861] synonym: "KIAA0394" EXACT [UniProtKB:O60861] xref: EMBL:AB007854 xref: EMBL:AF231998 xref: EMBL:AJ224876 xref: EMBL:BC001152 xref: EMBL:BC006454 xref: HGNC:HGNC:4169 xref: UniGene:Hs.258855 xref: UniGene:Hs.462214 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001417 ! GAS7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004685 name: GPRASP2_human def: "G-protein coupled receptor-associated sorting protein 2 gene" [UniProtKB:Q96D09] xref: EMBL:AK092981 xref: EMBL:AL035427 xref: EMBL:BC013576 xref: EMBL:BC036772 xref: HGNC:HGNC:25169 xref: UniGene:Hs.656888 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005405 ! GASP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004686 name: GNB5_human def: "Guanine nucleotide-binding protein subunit beta-5 gene" [UniProtKB:O14775] xref: EMBL:AF017656 xref: EMBL:AF300650 xref: EMBL:AF501885 xref: EMBL:BC013997 xref: HGNC:HGNC:4401 xref: UniGene:Hs.155090 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006142 ! GBB5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004688 name: GNB2L1_human def: "Guanine nucleotide-binding protein subunit beta-2-like 1 gene" [UniProtKB:P63244] xref: EMBL:BC000214 xref: EMBL:BC000366 xref: EMBL:BC010119 xref: EMBL:BC014256 xref: EMBL:BC014788 xref: EMBL:BC017287 xref: EMBL:BC019093 xref: EMBL:BC019362 xref: EMBL:BC021993 xref: EMBL:BC032006 xref: EMBL:CR456978 xref: EMBL:M24194 xref: HGNC:HGNC:4399 xref: UniGene:Hs.5662 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005739 ! GBLP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004690 name: GCN5L2_human def: "General control of amino acid synthesis protein 5-like 2 gene" [UniProtKB:Q92830] synonym: "GCN5" EXACT [UniProtKB:Q92830] synonym: "HGCN5" EXACT [UniProtKB:Q92830] xref: EMBL:AF029777 xref: EMBL:U57316 xref: HGNC:HGNC:4201 xref: UniGene:Hs.463045 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005647 ! GCNL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004691 name: GDF9_human def: "Growth/differentiation factor 9 precursor gene" [UniProtKB:O60383] xref: EMBL:AC004500 xref: EMBL:BC096228 xref: EMBL:BC096229 xref: EMBL:BC096230 xref: EMBL:BC096231 xref: HGNC:HGNC:4224 xref: UniGene:Hs.25022 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006180 ! GDF9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004692 name: ARHGDIA_human def: "Rho GDP-dissociation inhibitor 1 gene" [UniProtKB:P52565] synonym: "GDIA1" EXACT [UniProtKB:P52565] xref: EMBL:AF498926 xref: EMBL:BC005851 xref: EMBL:BC005875 xref: EMBL:BC008701 xref: EMBL:BC009759 xref: EMBL:BC016031 xref: EMBL:BC016185 xref: EMBL:BC024258 xref: EMBL:BC027730 xref: EMBL:BC075827 xref: EMBL:BT006884 xref: EMBL:D13989 xref: EMBL:M97579 xref: EMBL:X63863 xref: EMBL:X69550 xref: HGNC:HGNC:678 xref: UniGene:Hs.159161 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0032833 ! GDIR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004693 name: GMNN_human def: "Geminin gene" [UniProtKB:O75496] xref: EMBL:AF067855 xref: EMBL:AL133264 xref: EMBL:BC005185 xref: EMBL:BC005389 xref: HGNC:HGNC:17493 xref: UniGene:Hs.234896 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001432 ! GEMI_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004694 name: GFI1B_human def: "Zinc finger protein Gfi-1b gene" [UniProtKB:Q5VTD9] xref: EMBL:AF081946 xref: EMBL:AL593851 xref: EMBL:AY428733 xref: EMBL:BC035626 xref: EMBL:BC043371 xref: EMBL:CH471090 xref: EMBL:CR536546 xref: HGNC:HGNC:4238 xref: UniGene:Hs.553160 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001898 ! GFI1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004695 name: GFI1_human def: "Zinc finger protein Gfi-1 gene" [UniProtKB:Q99684] synonym: "ZNF163" EXACT [UniProtKB:Q99684] xref: EMBL:BC032751 xref: EMBL:BC074866 xref: EMBL:BC074867 xref: EMBL:U67369 xref: HGNC:HGNC:4237 xref: UniGene:Hs.73172 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002083 ! GFI1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004697 name: GGA2_human def: "ADP-ribosylation factor-binding protein GGA2 gene" [UniProtKB:Q9UJY4] synonym: "KIAA1080" EXACT [UniProtKB:Q9UJY4] xref: EMBL:AB029003 xref: EMBL:AC002400 xref: EMBL:AF165531 xref: EMBL:AF190863 xref: EMBL:AF233522 xref: EMBL:AF323754 xref: EMBL:BC000284 xref: HGNC:HGNC:16064 xref: UniGene:Hs.460336 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005200 ! GGA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004699 name: GIT1_human def: "ARF GTPase-activating protein GIT1 gene" [UniProtKB:Q9Y2X7] xref: EMBL:AF124490 xref: EMBL:BC006227 xref: EMBL:BC048196 xref: HGNC:HGNC:4272 xref: UniGene:Hs.514051 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005397 ! GIT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004702 name: GLI3_human def: "Zinc finger protein GLI3 gene" [UniProtKB:P10071] xref: EMBL:AC005026 xref: EMBL:AC005028 xref: EMBL:AC005158 xref: EMBL:AJ250408 xref: EMBL:BC113616 xref: EMBL:BC117168 xref: EMBL:CH236951 xref: EMBL:M20674 xref: EMBL:M57609 xref: HGNC:HGNC:4319 xref: UniGene:Hs.21509 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005850 ! GLI3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004703 name: GLIS3_human def: "Zinc finger protein GLIS3 gene" [UniProtKB:Q8NEA6] synonym: "ZNF515" EXACT [UniProtKB:Q8NEA6] xref: EMBL:BC033899 xref: HGNC:HGNC:28510 xref: UniGene:Hs.162125 xref: UniGene:Hs.644570 xref: UniGene:Hs.648821 xref: UniGene:Hs.677552 xref: UniGene:Hs.699131 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005201 ! GLIS3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004704 name: PRKCSH_human def: "Glucosidase 2 subunit beta precursor gene" [UniProtKB:P14314] synonym: "G19P1" EXACT [UniProtKB:P14314] xref: EMBL:AF144075 xref: EMBL:BC013586 xref: EMBL:BC015154 xref: EMBL:BT009858 xref: EMBL:J03075 xref: EMBL:U50317 xref: EMBL:U50318 xref: EMBL:U50319 xref: EMBL:U50320 xref: EMBL:U50321 xref: EMBL:U50322 xref: EMBL:U50323 xref: EMBL:U50324 xref: EMBL:U50325 xref: EMBL:U50326 xref: HGNC:HGNC:9411 xref: UniGene:Hs.610830 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006228 ! GLU2B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004706 name: SHMT1_human def: "Serine hydroxymethyltransferase, cytosolic gene" [UniProtKB:P34896] xref: EMBL:BC022874 xref: EMBL:BC038598 xref: EMBL:L11931 xref: EMBL:L23928 xref: EMBL:Y14485 xref: EMBL:Y14486 xref: EMBL:Y14487 xref: HGNC:HGNC:10850 xref: UniGene:Hs.513987 xref: UniGene:Hs.636044 xref: UniGene:Hs.706506 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006184 ! GLYC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004707 name: GML_human def: "Glycosyl-phosphatidylinositol-anchored molecule-like protein precursor gene" [UniProtKB:Q99445] synonym: "LY6DL" EXACT [UniProtKB:Q99445] xref: EMBL:AB000381 xref: EMBL:BC074930 xref: EMBL:BC126336 xref: EMBL:BC126338 xref: EMBL:D84290 xref: HGNC:HGNC:4375 xref: UniGene:Hs.661218 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002064 ! GML_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004709 name: GNAI1_human def: "Guanine nucleotide-binding protein G(i), alpha-1 subunit gene" [UniProtKB:P63096] xref: EMBL:AF055013 xref: EMBL:AF493905 xref: EMBL:AL049933 xref: EMBL:BC026326 xref: EMBL:BT019775 xref: EMBL:M17219 xref: EMBL:M20594 xref: EMBL:M20595 xref: EMBL:M20596 xref: HGNC:HGNC:4384 xref: UniGene:Hs.134587 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005493 ! GNAI1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004710 name: GNAI2_human def: "Guanine nucleotide-binding protein G(i), alpha-2 subunit gene" [UniProtKB:P04899] synonym: "GNAI2B" EXACT [UniProtKB:P04899] xref: EMBL:AF493906 xref: EMBL:BC012138 xref: EMBL:BC016995 xref: EMBL:J03004 xref: EMBL:M20586 xref: EMBL:M20587 xref: EMBL:M20588 xref: EMBL:M20589 xref: EMBL:M20590 xref: EMBL:M20591 xref: EMBL:M20592 xref: EMBL:M20593 xref: EMBL:X04828 xref: EMBL:X07854 xref: HGNC:HGNC:4385 xref: UniGene:Hs.77269 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005754 ! GNAI2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004712 name: GNL3_human def: "Guanine nucleotide-binding protein-like 3 gene" [UniProtKB:Q9BVP2] synonym: "E2IG3" EXACT [UniProtKB:Q9BVP2] synonym: "NS" EXACT [UniProtKB:Q9BVP2] xref: EMBL:AF191018 xref: EMBL:AK027514 xref: EMBL:AK027516 xref: EMBL:BC001024 xref: HGNC:HGNC:29931 xref: UniGene:Hs.313544 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002103 ! GNL3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004713 name: GNPTG_human def: "N-acetylglucosamine-1-phosphotransferase subunit gamma precursor gene" [UniProtKB:Q9UJJ9] synonym: "CAB56184" EXACT [UniProtKB:Q9UJJ9] synonym: "GNPTAG" EXACT [UniProtKB:Q9UJJ9] synonym: "LP2537" EXACT [UniProtKB:Q9UJJ9] xref: EMBL:AF302786 xref: EMBL:AL031709 xref: EMBL:AY203933 xref: EMBL:BC014592 xref: HGNC:HGNC:23026 xref: UniGene:Hs.241575 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005572 ! GNPTG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004714 name: GOLGA2_human def: "Golgin subfamily A member 2 gene" [UniProtKB:Q08379] xref: EMBL:AF248953 xref: EMBL:AL590708 xref: EMBL:BC006381 xref: EMBL:BC014188 xref: EMBL:BC069268 xref: EMBL:BT007248 xref: EMBL:L06147 xref: HGNC:HGNC:4425 xref: UniGene:Hs.155827 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006274 ! GOGA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004715 name: GOLGB1_human def: "Golgin subfamily B member 1 gene" [UniProtKB:Q14789] xref: EMBL:D25542 xref: EMBL:X75304 xref: HGNC:HGNC:4429 xref: UniGene:Hs.213389 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006272 ! GOGB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004717 name: GORASP2_human def: "Golgi reassembly-stacking protein 2 gene" [UniProtKB:Q9H8Y8] xref: EMBL:AK023082 xref: EMBL:AK023201 xref: EMBL:AK027349 xref: EMBL:AL117430 xref: EMBL:BC007770 xref: HGNC:HGNC:17500 xref: UniGene:Hs.431317 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005241 ! GORS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004719 name: GPR135_human def: "Probable G-protein coupled receptor 135 gene" [UniProtKB:Q8IZ08] xref: EMBL:AB065563 xref: EMBL:AY255588 xref: EMBL:AY288418 xref: EMBL:BC032831 xref: HGNC:HGNC:19991 xref: UniGene:Hs.647573 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006306 ! GP135_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004721 name: GPAA1_human def: "Glycosylphosphatidylinositol anchor attachment 1 protein gene" [UniProtKB:O43292] synonym: "GAA1" EXACT [UniProtKB:O43292] xref: EMBL:AB002135 xref: EMBL:AB002137 xref: EMBL:AB006969 xref: EMBL:AB017267 xref: EMBL:AL157437 xref: EMBL:BC003171 xref: EMBL:BC004129 xref: EMBL:BC006383 xref: HGNC:HGNC:4446 xref: UniGene:Hs.627962 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006273 ! GPAA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004723 name: GPS2_human def: "G protein pathway suppressor 2 gene" [UniProtKB:Q13227] xref: EMBL:AL122080 xref: EMBL:AL157493 xref: EMBL:BC013652 xref: EMBL:U28963 xref: HGNC:HGNC:4550 xref: UniGene:Hs.438219 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001746 ! GPS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004724 name: GPSM2_human def: "G-protein-signaling modulator 2 gene" [UniProtKB:P81274] synonym: "LGN" EXACT [UniProtKB:P81274] xref: EMBL:AY136740 xref: EMBL:BC027732 xref: EMBL:U54999 xref: HGNC:HGNC:29501 xref: UniGene:Hs.584901 xref: UniGene:Hs.658489 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005492 ! GPSM2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004725 name: GRB2_human def: "Growth factor receptor-bound protein 2 gene" [UniProtKB:P62993] synonym: "ASH" EXACT [UniProtKB:P62993] xref: EMBL:AF063614 xref: EMBL:AF063615 xref: EMBL:AF063616 xref: EMBL:AF063617 xref: EMBL:AF063618 xref: EMBL:AF498925 xref: EMBL:BC000631 xref: EMBL:CR541942 xref: EMBL:L29511 xref: EMBL:M96995 xref: EMBL:X62852 xref: HGNC:HGNC:4566 xref: UniGene:Hs.444356 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005454 ! GRB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004726 name: GRIK5_human def: "Glutamate receptor, ionotropic kainate 5 precursor gene" [UniProtKB:Q16478] synonym: "GRIK2" EXACT [UniProtKB:Q16478] xref: EMBL:S40369 xref: HGNC:HGNC:4583 xref: UniGene:Hs.367799 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006285 ! GRIK5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004728 name: GRIP2_human def: "Glutamate receptor-interacting protein 2 gene" [UniProtKB:Q9C0E4] synonym: "KIAA1719" EXACT [UniProtKB:Q9C0E4] xref: EMBL:AB051506 xref: EMBL:AK024507 xref: EMBL:AK074145 xref: HGNC:HGNC:23841 xref: UniGene:Hs.517819 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005960 ! GRIP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004729 name: GRLF1_human def: "Glucocorticoid receptor DNA-binding factor 1 gene" [UniProtKB:Q9NRY4] synonym: "GRF1" EXACT [UniProtKB:Q9NRY4] synonym: "KIAA1722" EXACT [UniProtKB:Q9NRY4] xref: EMBL:AB051509 xref: EMBL:AF159851 xref: EMBL:M73077 xref: HGNC:HGNC:4591 xref: UniGene:Hs.509447 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002160 ! GRLF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004730 name: GRN_human def: "Granulins precursor gene" [UniProtKB:P28799] xref: EMBL:AF055008 xref: EMBL:BC000324 xref: EMBL:BC010577 xref: EMBL:M75161 xref: EMBL:X62320 xref: HGNC:HGNC:4601 xref: UniGene:Hs.514220 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005961 ! GRN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004731 name: HSPA9_human def: "Stress-70 protein, mitochondrial precursor gene" [UniProtKB:P38646] synonym: "GRP75" EXACT [UniProtKB:P38646] synonym: "HSPA9B" EXACT [UniProtKB:P38646] xref: EMBL:BC000478 xref: EMBL:BC024034 xref: EMBL:L11066 xref: EMBL:L15189 xref: HGNC:HGNC:5244 xref: UniGene:Hs.184233 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005828 ! GRP75_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004732 name: HSPA5_human def: "78 kDa glucose-regulated protein precursor gene" [UniProtKB:P11021] synonym: "GRP78" EXACT [UniProtKB:P11021] xref: EMBL:AF188611 xref: EMBL:AF216292 xref: EMBL:AJ271729 xref: EMBL:BC020235 xref: EMBL:DQ385847 xref: EMBL:M19645 xref: EMBL:X59969 xref: EMBL:X87949 xref: HGNC:HGNC:5238 xref: UniGene:Hs.605502 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005843 ! GRP78_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004733 name: GRWD1_human def: "Glutamate-rich WD repeat-containing protein 1 gene" [UniProtKB:Q9BQ67] synonym: "GRWD" EXACT [UniProtKB:Q9BQ67] synonym: "WDR28" EXACT [UniProtKB:Q9BQ67] xref: EMBL:AF337808 xref: EMBL:BC002440 xref: HGNC:HGNC:21270 xref: UniGene:Hs.400625 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005687 ! GRWD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004734 name: GSE1_human def: "Genetic suppressor element 1 gene" [UniProtKB:Q14687] synonym: "KIAA0182" EXACT [UniProtKB:Q14687] xref: EMBL:BC000753 xref: EMBL:BC009854 xref: EMBL:BC037556 xref: EMBL:BQ214916 xref: EMBL:D80004 xref: HGNC:HGNC:28979 xref: UniGene:Hs.461647 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005595 ! GSE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004735 name: GSPT1_human def: "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A gene" [UniProtKB:P15170] synonym: "ERF3A" EXACT [UniProtKB:P15170] xref: EMBL:U95742 xref: EMBL:X17644 xref: HGNC:HGNC:4621 xref: UniGene:Hs.528780 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001520 ! ERF3A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004736 name: GSTM4_human def: "Glutathione S-transferase Mu 4 gene" [UniProtKB:Q03013] xref: EMBL:BC015513 xref: EMBL:BC108729 xref: EMBL:CR541869 xref: EMBL:M96233 xref: EMBL:M96234 xref: EMBL:M99422 xref: EMBL:X56837 xref: EMBL:X68677 xref: HGNC:HGNC:4636 xref: UniGene:Hs.348387 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006144 ! GSTM4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004739 name: GTSE1_human def: "G2 and S phase-expressed protein 1 gene" [UniProtKB:Q9NYZ3] xref: EMBL:AF223408 xref: EMBL:AK222806 xref: EMBL:AL031588 xref: EMBL:BC006325 xref: EMBL:BC075828 xref: EMBL:Z93024 xref: HGNC:HGNC:13698 xref: UniGene:Hs.386189 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002180 ! GTSE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004741 name: HIST1H1A_human def: "Histone H1.1 gene" [UniProtKB:Q02539] synonym: "H1F1" EXACT [UniProtKB:Q02539] xref: EMBL:AF531299 xref: EMBL:BC069492 xref: EMBL:BC101593 xref: EMBL:BC112140 xref: EMBL:X57130 xref: HGNC:HGNC:4715 xref: UniGene:Hs.150206 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005863 ! H11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004742 name: HIST1H1E_human def: "Histone H1.4 gene" [UniProtKB:P10412] synonym: "H1F4" EXACT [UniProtKB:P10412] xref: EMBL:AF531302 xref: EMBL:AL353759 xref: EMBL:BC096168 xref: EMBL:BC096169 xref: EMBL:BC099632 xref: EMBL:M60748 xref: HGNC:HGNC:4718 xref: UniGene:Hs.248133 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005838 ! H14_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004743 name: H2AFX_human def: "Histone H2A.x gene" [UniProtKB:P16104] synonym: "H2AX" EXACT [UniProtKB:P16104] xref: EMBL:BC004915 xref: EMBL:BC011694 xref: EMBL:BC013416 xref: EMBL:CR457079 xref: EMBL:DQ015918 xref: EMBL:X14850 xref: HGNC:HGNC:4739 xref: UniGene:Hs.477879 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001526 ! H2AX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004744 name: HIST1H2BC_human def: "Histone H2B type 1-C/E/F/G/I gene" [UniProtKB:P62807] synonym: "H2BFL" EXACT [UniProtKB:P62807] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005771 ! H2B1C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004745 name: HIST1H2BE_human def: "Histone H2B type 1-C/E/F/G/I gene" [UniProtKB:P62807] synonym: "H2BFH" EXACT [UniProtKB:P62807] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005771 ! H2B1C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004746 name: HIST1H2BF_human def: "Histone H2B type 1-C/E/F/G/I gene" [UniProtKB:P62807] synonym: "H2BFG" EXACT [UniProtKB:P62807] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005771 ! H2B1C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004747 name: HIST1H2BG_human def: "Histone H2B type 1-C/E/F/G/I gene" [UniProtKB:P62807] synonym: "H2BFA" EXACT [UniProtKB:P62807] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005771 ! H2B1C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004748 name: HIST1H2BI_human def: "Histone H2B type 1-C/E/F/G/I gene" [UniProtKB:P62807] synonym: "H2BFK" EXACT [UniProtKB:P62807] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005771 ! H2B1C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004749 name: HIST1H3A_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FA" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004750 name: HIST1H3B_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FL" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004751 name: HIST1H3C_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FC" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004752 name: HIST1H3D_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FB" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004753 name: HIST1H3E_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FD" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004754 name: HIST1H3F_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FI" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004755 name: HIST1H3G_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FH" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004756 name: HIST1H3H_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FK" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004757 name: HIST1H3I_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FF" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004758 name: HIST1H3J_human def: "Histone H3.1 gene" [UniProtKB:P68431] synonym: "H3FJ" EXACT [UniProtKB:P68431] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005221 ! H31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004759 name: HIST2H3A_human def: "Histone H3.2 gene" [UniProtKB:Q71DI3] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005285 ! H32_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004760 name: HIST2H3C_human def: "Histone H3.2 gene" [UniProtKB:Q71DI3] synonym: "H3F2" EXACT [UniProtKB:Q71DI3] synonym: "H3FM" EXACT [UniProtKB:Q71DI3] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005285 ! H32_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004761 name: H3F3A_human def: "Histone H3.3 gene" [UniProtKB:P84243] synonym: "H3.3A" EXACT [UniProtKB:P84243] synonym: "H3F3" EXACT [UniProtKB:P84243] synonym: "PP781" EXACT [UniProtKB:P84243] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005927 ! H33_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004762 name: H3F3B_human def: "Histone H3.3 gene" [UniProtKB:P84243] synonym: "H3.3B" EXACT [UniProtKB:P84243] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005927 ! H33_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004776 name: HLA-DQA1_human def: "HLA class II histocompatibility antigen, DQ(3) alpha chain precursor gene" [UniProtKB:P01909] xref: EMBL:BC008585 xref: EMBL:M20506 xref: EMBL:M34997 xref: EMBL:U03675 xref: EMBL:U92032 xref: EMBL:X00370 xref: EMBL:Z84489 xref: HGNC:HGNC:4942 xref: UniGene:Hs.387679 xref: UniGene:Hs.591798 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006147 ! HA23_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004777 name: HAP1_human def: "Huntingtin-associated protein 1 gene" [UniProtKB:P54257] synonym: "HAP2" EXACT [UniProtKB:P54257] synonym: "HLP1" EXACT [UniProtKB:P54257] xref: EMBL:AF040723 xref: EMBL:AJ012824 xref: EMBL:AJ224877 xref: EMBL:AK022007 xref: EMBL:U38371 xref: HGNC:HGNC:4812 xref: UniGene:Hs.158300 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006153 ! HAP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004778 name: GSG2_human def: "Serine/threonine-protein kinase haspin gene" [UniProtKB:Q8TF76] xref: EMBL:AB039834 xref: EMBL:AF289865 xref: EMBL:AK056691 xref: EMBL:BC047457 xref: HGNC:HGNC:19682 xref: UniGene:Hs.534059 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001999 ! HASP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004779 name: HBA1_human def: "Hemoglobin subunit alpha gene" [UniProtKB:P69905] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006221 ! HBA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004780 name: HBA2_human def: "Hemoglobin subunit alpha gene" [UniProtKB:P69905] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006221 ! HBA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004781 name: HBP1_human def: "HMG box-containing protein 1 gene" [UniProtKB:O60381] xref: EMBL:AC004492 xref: EMBL:AF182038 xref: EMBL:AK074353 xref: EMBL:BC017069 xref: EMBL:BC022329 xref: HGNC:HGNC:23200 xref: UniGene:Hs.162032 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001407 ! HBP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004782 name: HCFC1_human def: "Host cell factor gene" [UniProtKB:P51610] synonym: "HCF1" EXACT [UniProtKB:P51610] synonym: "HFC1" EXACT [UniProtKB:P51610] xref: EMBL:BC063435 xref: EMBL:L20010 xref: EMBL:U52112 xref: EMBL:X79198 xref: HGNC:HGNC:4839 xref: UniGene:Hs.83634 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001650 ! HCFC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004783 name: HCK_human def: "Tyrosine-protein kinase HCK gene" [UniProtKB:P08631] xref: EMBL:AK026432 xref: EMBL:AL049539 xref: EMBL:AL353092 xref: EMBL:BC014435 xref: EMBL:BC094847 xref: EMBL:BC108930 xref: EMBL:BC108931 xref: EMBL:BC113854 xref: EMBL:BC114463 xref: EMBL:M16591 xref: EMBL:M16592 xref: EMBL:X58741 xref: EMBL:X58742 xref: EMBL:X58743 xref: HGNC:HGNC:4840 xref: UniGene:Hs.655210 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005894 ! HCK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004785 name: HDAC11_human def: "Histone deacetylase 11 gene" [UniProtKB:Q96DB2] xref: EMBL:AK025426 xref: EMBL:AK025890 xref: EMBL:AL137362 xref: EMBL:BC009676 xref: HGNC:HGNC:19086 xref: UniGene:Hs.661908 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005701 ! HDA11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004786 name: HDAC1_human def: "Histone deacetylase 1 gene" [UniProtKB:Q13547] synonym: "RPD3L1" EXACT [UniProtKB:Q13547] xref: EMBL:BC000301 xref: EMBL:D50405 xref: EMBL:U50079 xref: HGNC:HGNC:4852 xref: UniGene:Hs.88556 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005484 ! HDAC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004787 name: HDAC2_human def: "Histone deacetylase 2 gene" [UniProtKB:Q92769] xref: EMBL:AL590398 xref: EMBL:AL671967 xref: EMBL:BC031055 xref: EMBL:U31814 xref: HGNC:HGNC:4853 xref: UniGene:Hs.3352 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005343 ! HDAC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004788 name: HDAC3_human def: "Histone deacetylase 3 gene" [UniProtKB:O15379] xref: EMBL:AF005482 xref: EMBL:AF039703 xref: EMBL:AF053137 xref: EMBL:AF053138 xref: EMBL:AF053139 xref: EMBL:AF059650 xref: EMBL:BC000614 xref: EMBL:U66914 xref: EMBL:U75696 xref: EMBL:U75697 xref: HGNC:HGNC:4854 xref: UniGene:Hs.519632 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001376 ! HDAC3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004789 name: HDAC4_human def: "Histone deacetylase 4 gene" [UniProtKB:P56524] synonym: "KIAA0288" EXACT [UniProtKB:P56524] xref: EMBL:AB006626 xref: EMBL:AF132607 xref: HGNC:HGNC:14063 xref: UniGene:Hs.20516 xref: UniGene:Hs.688314 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001679 ! HDAC4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004790 name: HDAC5_human def: "Histone deacetylase 5 gene" [UniProtKB:Q9UQL6] synonym: "KIAA0600" EXACT [UniProtKB:Q9UQL6] xref: EMBL:AB011172 xref: EMBL:AF039691 xref: EMBL:AF132608 xref: EMBL:BC013140 xref: EMBL:BC051824 xref: EMBL:BK000028 xref: HGNC:HGNC:14068 xref: UniGene:Hs.438782 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002244 ! HDAC5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004791 name: HDAC6_human def: "Histone deacetylase 6 gene" [UniProtKB:Q9UBN7] synonym: "JM21" EXACT [UniProtKB:Q9UBN7] xref: EMBL:AF132609 xref: EMBL:AJ011972 xref: HGNC:HGNC:14064 xref: UniGene:Hs.6764 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002192 ! HDAC6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004793 name: HDAC9_human def: "Histone deacetylase 9 gene" [UniProtKB:Q9UKV0] synonym: "HDAC7" EXACT [UniProtKB:Q9UKV0] synonym: "HDAC7B" EXACT [UniProtKB:Q9UKV0] synonym: "HDRP" EXACT [UniProtKB:Q9UKV0] synonym: "KIAA0744" EXACT [UniProtKB:Q9UKV0] synonym: "MITR" EXACT [UniProtKB:Q9UKV0] xref: EMBL:AB018287 xref: EMBL:AC004994 xref: EMBL:AF124924 xref: EMBL:AJ459808 xref: EMBL:AY032737 xref: EMBL:AY032738 xref: EMBL:AY197371 xref: EMBL:BC111735 xref: HGNC:HGNC:14065 xref: UniGene:Hs.196054 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002222 ! HDAC9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004796 name: HEPACAM_human def: "Hepatocyte cell adhesion molecule precursor gene" [UniProtKB:Q14CZ8] xref: EMBL:AK098396 xref: EMBL:AK122595 xref: EMBL:AL834419 xref: EMBL:AY047587 xref: EMBL:BC104831 xref: EMBL:BC113562 xref: HGNC:HGNC:26361 xref: UniGene:Hs.159863 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001796 ! HECAM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004797 name: HECTD3_human def: "Probable E3 ubiquitin-protein ligase HECTD3 gene" [UniProtKB:Q5T447] xref: EMBL:AK024809 xref: EMBL:AL359473 xref: EMBL:BC019105 xref: HGNC:HGNC:26117 xref: UniGene:Hs.525084 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001875 ! HECD3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004798 name: HECW1_human def: "E3 ubiquitin-protein ligase HECW1 gene" [UniProtKB:Q76N89] synonym: "KIAA0322" EXACT [UniProtKB:Q76N89] synonym: "NEDL1" EXACT [UniProtKB:Q76N89] xref: EMBL:AB002320 xref: EMBL:AB048365 xref: HGNC:HGNC:22195 xref: UniGene:Hs.164453 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005962 ! HECW1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004799 name: HELLS_human def: "Lymphoid-specific helicase gene" [UniProtKB:Q9NRZ9] synonym: "Nbla10143" EXACT [UniProtKB:Q9NRZ9] synonym: "PASG" EXACT [UniProtKB:Q9NRZ9] synonym: "SMARCA6" EXACT [UniProtKB:Q9NRZ9] xref: EMBL:AB074174 xref: EMBL:AB102717 xref: EMBL:AB102718 xref: EMBL:AB102719 xref: EMBL:AB102720 xref: EMBL:AB102721 xref: EMBL:AB102722 xref: EMBL:AB113249 xref: EMBL:AF155827 xref: EMBL:AL138759 xref: EMBL:AY007108 xref: EMBL:BC015477 xref: EMBL:BC029381 xref: EMBL:BC030963 xref: EMBL:BC031004 xref: EMBL:BX538033 xref: HGNC:HGNC:4861 xref: UniGene:Hs.655830 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002161 ! HELLS_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004800 name: HERC5_human def: "Probable E3 ubiquitin-protein ligase HERC5 gene" [UniProtKB:Q9UII4] synonym: "CEB1" EXACT [UniProtKB:Q9UII4] synonym: "CEBP1" EXACT [UniProtKB:Q9UII4] xref: EMBL:AB027289 xref: HGNC:HGNC:24368 xref: UniGene:Hs.26663 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002206 ! HERC5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004801 name: HEXIM1_human def: "Protein HEXIM1 gene" [UniProtKB:O94992] synonym: "CLP1" EXACT [UniProtKB:O94992] synonym: "EDG1" EXACT [UniProtKB:O94992] synonym: "HIS1" EXACT [UniProtKB:O94992] synonym: "MAQ1" EXACT [UniProtKB:O94992] xref: EMBL:AB021179 xref: EMBL:BC006460 xref: HGNC:HGNC:24953 xref: UniGene:Hs.15299 xref: UniGene:Hs.586945 xref: UniGene:Hs.634944 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001445 ! HEXI1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004802 name: HEXIM2_human def: "Protein HEXIM2 gene" [UniProtKB:Q96MH2] synonym: "L3" EXACT [UniProtKB:Q96MH2] xref: EMBL:AK056946 xref: EMBL:AY598322 xref: EMBL:BC003531 xref: EMBL:BC012474 xref: EMBL:BC025970 xref: EMBL:CH471178 xref: HGNC:HGNC:28591 xref: UniGene:Hs.56382 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002049 ! HEXI2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004803 name: HGF_human def: "Hepatocyte growth factor precursor gene" [UniProtKB:P14210] synonym: "HPTA" EXACT [UniProtKB:P14210] xref: EMBL:AC004960 xref: EMBL:AY246560 xref: EMBL:BC022308 xref: EMBL:BC063485 xref: EMBL:BC130284 xref: EMBL:BC130286 xref: EMBL:CH236949 xref: EMBL:D90334 xref: EMBL:L02931 xref: EMBL:M29145 xref: EMBL:M55379 xref: EMBL:M60718 xref: EMBL:M73239 xref: EMBL:M73240 xref: EMBL:M75966 xref: EMBL:M75967 xref: EMBL:M75968 xref: EMBL:M75969 xref: EMBL:M75971 xref: EMBL:M75972 xref: EMBL:M75973 xref: EMBL:M75974 xref: EMBL:M75975 xref: EMBL:M75976 xref: EMBL:M75977 xref: EMBL:M75978 xref: EMBL:M75979 xref: EMBL:M75980 xref: EMBL:M75981 xref: EMBL:M75982 xref: EMBL:M75983 xref: EMBL:M77227 xref: EMBL:U46010 xref: EMBL:X16323 xref: EMBL:X57574 xref: HGNC:HGNC:4893 xref: UniGene:Hs.396530 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001518 ! HGF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004804 name: HGS_human def: "Hepatocyte growth factor-regulated tyrosine kinase substrate gene" [UniProtKB:O14964] synonym: "HRS" EXACT [UniProtKB:O14964] xref: EMBL:AF260566 xref: EMBL:BC003565 xref: EMBL:BT009754 xref: EMBL:D84064 xref: EMBL:U43895 xref: HGNC:HGNC:4897 xref: UniGene:Hs.514590 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005280 ! HGS_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004805 name: HIC1_human def: "Hypermethylated in cancer 1 protein gene" [UniProtKB:Q14526] synonym: "ZBTB29" EXACT [UniProtKB:Q14526] xref: EMBL:L41919 xref: HGNC:HGNC:4909 xref: UniGene:Hs.695682 xref: UniGene:Hs.706722 xref: UniGene:Hs.72956 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001783 ! HIC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004806 name: HIF1A_human def: "Hypoxia-inducible factor 1 alpha gene" [UniProtKB:Q16665] synonym: "MOP1" EXACT [UniProtKB:Q16665] xref: EMBL:AB073325 xref: EMBL:AF050115 xref: EMBL:AF050116 xref: EMBL:AF050117 xref: EMBL:AF050118 xref: EMBL:AF050119 xref: EMBL:AF050120 xref: EMBL:AF050121 xref: EMBL:AF050122 xref: EMBL:AF050123 xref: EMBL:AF050124 xref: EMBL:AF050125 xref: EMBL:AF050126 xref: EMBL:AF050127 xref: EMBL:AF207601 xref: EMBL:AF207602 xref: EMBL:AF208487 xref: EMBL:AF304431 xref: EMBL:BC012527 xref: EMBL:BT009776 xref: EMBL:U22431 xref: EMBL:U29165 xref: HGNC:HGNC:4910 xref: UniGene:Hs.597216 xref: UniGene:Hs.654600 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005430 ! HIF1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004807 name: HIP1_human def: "Huntingtin-interacting protein 1 gene" [UniProtKB:O00291] xref: EMBL:AC004491 xref: EMBL:AC018720 xref: EMBL:AF052261 xref: EMBL:AF052262 xref: EMBL:AF052263 xref: EMBL:AF052264 xref: EMBL:AF052265 xref: EMBL:AF052266 xref: EMBL:AF052267 xref: EMBL:AF052268 xref: EMBL:AF052269 xref: EMBL:AF052270 xref: EMBL:AF052271 xref: EMBL:AF052272 xref: EMBL:AF052273 xref: EMBL:AF052274 xref: EMBL:AF052275 xref: EMBL:AF052276 xref: EMBL:AF052277 xref: EMBL:AF052278 xref: EMBL:AF052279 xref: EMBL:AF052280 xref: EMBL:AF052281 xref: EMBL:AF052282 xref: EMBL:AF052283 xref: EMBL:AF052284 xref: EMBL:AF052285 xref: EMBL:AF052286 xref: EMBL:AF052287 xref: EMBL:AF052288 xref: EMBL:AF365404 xref: EMBL:U79734 xref: EMBL:Y09420 xref: HGNC:HGNC:4913 xref: UniGene:Hs.329266 xref: UniGene:Hs.619089 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006214 ! HIP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004808 name: HIPK1_human def: "Homeodomain-interacting protein kinase 1 gene" [UniProtKB:Q86Z02] synonym: "KIAA0630" EXACT [UniProtKB:Q86Z02] xref: EMBL:AB014530 xref: EMBL:AB089957 xref: EMBL:AL833829 xref: EMBL:BC028408 xref: EMBL:BC033012 xref: EMBL:BC036057 xref: HGNC:HGNC:19006 xref: UniGene:Hs.532363 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005675 ! HIPK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004810 name: HMG20A_human def: "High mobility group protein 20A gene" [UniProtKB:Q9NP66] synonym: "HMGX1" EXACT [UniProtKB:Q9NP66] xref: EMBL:AC142496 xref: EMBL:AF146222 xref: EMBL:AK001601 xref: EMBL:AK223100 xref: EMBL:AL355736 xref: EMBL:AL355737 xref: EMBL:BC021959 xref: EMBL:BT006716 xref: EMBL:CH471136 xref: HGNC:HGNC:5001 xref: UniGene:Hs.69594 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005296 ! HM20A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004811 name: HMG20B_human def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related gene" [UniProtKB:Q9P0W2] synonym: "BRAF35" EXACT [UniProtKB:Q9P0W2] synonym: "HMGX2" EXACT [UniProtKB:Q9P0W2] synonym: "SMARCE1R" EXACT [UniProtKB:Q9P0W2] xref: EMBL:AC005786 xref: EMBL:AF072165 xref: EMBL:AF072836 xref: EMBL:AF146223 xref: EMBL:AF288679 xref: EMBL:AF331191 xref: EMBL:AK090733 xref: EMBL:AL355709 xref: EMBL:BC002552 xref: EMBL:BC003505 xref: EMBL:BC004408 xref: EMBL:BC021585 xref: EMBL:CR456754 xref: HGNC:HGNC:5002 xref: UniGene:Hs.406534 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002184 ! HM20B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004812 name: HMGB1_human def: "High mobility group protein B1 gene" [UniProtKB:P09429] synonym: "HMG1" EXACT [UniProtKB:P09429] xref: EMBL:AY377859 xref: EMBL:BC003378 xref: EMBL:BC030981 xref: EMBL:BC066889 xref: EMBL:BC067732 xref: EMBL:BT006940 xref: EMBL:BT020159 xref: EMBL:CR456863 xref: EMBL:CR749614 xref: EMBL:U51677 xref: EMBL:X12597 xref: HGNC:HGNC:4983 xref: UniGene:Hs.434102 xref: UniGene:Hs.593339 xref: UniGene:Hs.644368 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005929 ! HMGB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004813 name: HMOX2_human def: "Heme oxygenase 2 gene" [UniProtKB:P30519] synonym: "HO2" EXACT [UniProtKB:P30519] xref: EMBL:AF051306 xref: EMBL:AY771350 xref: EMBL:BC002396 xref: EMBL:BT019788 xref: EMBL:D21243 xref: EMBL:S34389 xref: HGNC:HGNC:5014 xref: UniGene:Hs.284279 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006148 ! HMOX2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004815 name: HNRPH1_human def: "Heterogeneous nuclear ribonucleoprotein H gene" [UniProtKB:P31943] synonym: "HNRPH" EXACT [UniProtKB:P31943] xref: EMBL:BC001348 xref: EMBL:L22009 xref: HGNC:HGNC:5041 xref: UniGene:Hs.604001 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005732 ! HNRH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004816 name: HNRPH3_human def: "Heterogeneous nuclear ribonucleoprotein H3 gene" [UniProtKB:P31942] xref: EMBL:AF132360 xref: EMBL:AF132361 xref: EMBL:AF132362 xref: EMBL:AF132363 xref: EMBL:AF132364 xref: EMBL:AL117395 xref: EMBL:BC004511 xref: EMBL:BC039824 xref: EMBL:L32610 xref: HGNC:HGNC:5043 xref: UniGene:Hs.699337 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006277 ! HNRH3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004818 name: HNRPD_human def: "Heterogeneous nuclear ribonucleoprotein D0 gene" [UniProtKB:Q14103] synonym: "AUF1" EXACT [UniProtKB:Q14103] xref: EMBL:AC124016 xref: EMBL:AF026126 xref: EMBL:AF039575 xref: EMBL:BC002401 xref: EMBL:BC023977 xref: EMBL:BC026015 xref: EMBL:D55671 xref: EMBL:D55672 xref: EMBL:D55673 xref: EMBL:D55674 xref: EMBL:M94630 xref: EMBL:X03910 xref: HGNC:HGNC:5036 xref: UniGene:Hs.480073 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005686 ! HNRPD_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004819 name: HNRPF_human def: "Heterogeneous nuclear ribonucleoprotein F gene" [UniProtKB:P52597] xref: EMBL:AL512654 xref: EMBL:BC001432 xref: EMBL:BC004254 xref: EMBL:BC015580 xref: EMBL:BC016736 xref: EMBL:BC106008 xref: EMBL:L28010 xref: HGNC:HGNC:5039 xref: UniGene:Hs.701075 xref: UniGene:Hs.808 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005814 ! HNRPF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004820 name: RBMX_human def: "Heterogeneous nuclear ribonucleoprotein G gene" [UniProtKB:P38159] synonym: "HNRPG" EXACT [UniProtKB:P38159] synonym: "RBMXP1" EXACT [UniProtKB:P38159] xref: EMBL:AF266720 xref: EMBL:AF266721 xref: EMBL:AF266722 xref: EMBL:AF266723 xref: EMBL:AL683813 xref: EMBL:AY464692 xref: EMBL:BC006550 xref: EMBL:BC007435 xref: EMBL:Z23064 xref: HGNC:HGNC:9910 xref: UniGene:Hs.380118 xref: UniGene:Hs.699781 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005256 ! HNRPG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004821 name: HNRPK_human def: "Heterogeneous nuclear ribonucleoprotein K gene" [UniProtKB:P61978] synonym: "HNRNPK" EXACT [UniProtKB:P61978] xref: EMBL:AB209562 xref: EMBL:BC000355 xref: EMBL:BC014980 xref: EMBL:S74678 xref: EMBL:X72727 xref: HGNC:HGNC:5044 xref: UniGene:Hs.695973 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005235 ! HNRPK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004823 name: HOOK1_human def: "Hook homolog 1 gene" [UniProtKB:Q9UJC3] xref: EMBL:AC113175 xref: EMBL:AF044923 xref: EMBL:AL035416 xref: EMBL:BC011621 xref: HGNC:HGNC:19884 xref: UniGene:Hs.378836 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005594 ! HOOK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004824 name: HORMAD1_human def: "HORMA domain-containing protein 1 gene" [UniProtKB:Q86X24] synonym: "NOHMA" EXACT [UniProtKB:Q86X24] xref: EMBL:AL136755 xref: EMBL:AL356292 xref: EMBL:AY626344 xref: EMBL:BC033014 xref: EMBL:BC047406 xref: EMBL:CR533505 xref: HGNC:HGNC:25245 xref: UniGene:Hs.298312 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001340 ! A6NMK2_HUMAN relationship: codes_for CCO:B0001942 ! HORM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004825 name: HORMAD2_human def: "HORMA domain-containing protein 2 gene" [UniProtKB:Q8N7B1] xref: EMBL:AK098703 xref: EMBL:BC030013 xref: EMBL:CR456341 xref: HGNC:HGNC:28383 xref: UniGene:Hs.120391 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001967 ! HORM2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004826 name: HSPBP1_human def: "Hsp70-binding protein 1 gene" [UniProtKB:Q9NZL4] synonym: "HSPBP" EXACT [UniProtKB:Q9NZL4] synonym: "PP1845" EXACT [UniProtKB:Q9NZL4] xref: EMBL:AB020592 xref: EMBL:AF093420 xref: EMBL:AF187859 xref: EMBL:AF217996 xref: EMBL:AK130636 xref: EMBL:BC001236 xref: EMBL:BC002373 xref: EMBL:CR457118 xref: UniGene:Hs.53066 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005199 ! HPBP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004827 name: HPS6_human def: "Hermansky-Pudlak syndrome 6 protein gene" [UniProtKB:Q86YV9] xref: EMBL:AF536238 xref: EMBL:AK026154 xref: EMBL:BC011594 xref: EMBL:BC014993 xref: HGNC:HGNC:18817 xref: UniGene:Hs.125133 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006286 ! HPS6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004828 name: HRASLS3_human def: "HRAS-like suppressor 3 gene" [UniProtKB:P53816] synonym: "HREV107" EXACT [UniProtKB:P53816] xref: EMBL:AB030814 xref: EMBL:AF317086 xref: EMBL:BC001387 xref: EMBL:BC103807 xref: EMBL:X92814 xref: HGNC:HGNC:17825 xref: UniGene:Hs.502775 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001666 ! HRSL3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004829 name: MLL_human def: "Zinc finger protein HRX gene" [UniProtKB:Q03164] synonym: "ALL1" EXACT [UniProtKB:Q03164] synonym: "CXXC7" EXACT [UniProtKB:Q03164] synonym: "HRX" EXACT [UniProtKB:Q03164] synonym: "HTRX" EXACT [UniProtKB:Q03164] synonym: "KMT2A" EXACT [UniProtKB:Q03164] synonym: "TRX1" EXACT [UniProtKB:Q03164] xref: EMBL:AF231998 xref: EMBL:AY373585 xref: EMBL:D14540 xref: EMBL:L01986 xref: EMBL:L04284 xref: EMBL:L04731 xref: EMBL:S66432 xref: EMBL:S78570 xref: EMBL:U04737 xref: EMBL:X83604 xref: EMBL:Z69744 xref: EMBL:Z69745 xref: EMBL:Z69746 xref: EMBL:Z69747 xref: EMBL:Z69748 xref: EMBL:Z69749 xref: EMBL:Z69750 xref: EMBL:Z69751 xref: EMBL:Z69752 xref: EMBL:Z69753 xref: EMBL:Z69754 xref: EMBL:Z69755 xref: EMBL:Z69756 xref: EMBL:Z69757 xref: EMBL:Z69758 xref: EMBL:Z69759 xref: EMBL:Z69760 xref: EMBL:Z69761 xref: EMBL:Z69762 xref: EMBL:Z69763 xref: EMBL:Z69764 xref: EMBL:Z69765 xref: EMBL:Z69766 xref: EMBL:Z69767 xref: EMBL:Z69768 xref: EMBL:Z69769 xref: EMBL:Z69770 xref: EMBL:Z69772 xref: EMBL:Z69773 xref: EMBL:Z69774 xref: EMBL:Z69775 xref: EMBL:Z69776 xref: EMBL:Z69777 xref: EMBL:Z69778 xref: EMBL:Z69779 xref: EMBL:Z69780 xref: HGNC:HGNC:7132 xref: UniGene:Hs.258855 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005486 ! HRX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004830 name: HSP90AA1_human def: "Heat shock protein HSP 90-alpha gene" [UniProtKB:P07900] synonym: "HSP90A" EXACT [UniProtKB:P07900] synonym: "HSPC1" EXACT [UniProtKB:P07900] synonym: "HSPCA" EXACT [UniProtKB:P07900] xref: EMBL:AJ890082 xref: EMBL:AJ890083 xref: EMBL:BC000987 xref: EMBL:BC121062 xref: EMBL:D87666 xref: EMBL:DQ314871 xref: EMBL:M27024 xref: EMBL:M30626 xref: EMBL:X07270 xref: EMBL:X15183 xref: HGNC:HGNC:5253 xref: UniGene:Hs.523560 xref: UniGene:Hs.525600 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005698 ! HS90A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004831 name: HSP90AB1_human def: "Heat shock protein HSP 90-beta gene" [UniProtKB:P08238] synonym: "HSP90B" EXACT [UniProtKB:P08238] synonym: "HSPC2" EXACT [UniProtKB:P08238] synonym: "HSPCB" EXACT [UniProtKB:P08238] xref: EMBL:AF275719 xref: EMBL:AL136543 xref: EMBL:AL139392 xref: EMBL:AY359878 xref: EMBL:BC004928 xref: EMBL:BC009206 xref: EMBL:BC012807 xref: EMBL:BC014485 xref: EMBL:BC016753 xref: EMBL:BC068474 xref: EMBL:DQ314872 xref: EMBL:J04988 xref: EMBL:M16660 xref: EMBL:S70561 xref: HGNC:HGNC:5258 xref: UniGene:Hs.509736 xref: UniGene:Hs.696394 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005580 ! HS90B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004832 name: HSF4_human def: "Heat shock factor protein 4 gene" [UniProtKB:Q9ULV5] xref: EMBL:AB029347 xref: EMBL:AB029348 xref: EMBL:D87673 xref: HGNC:HGNC:5227 xref: UniGene:Hs.512156 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006048 ! HSF4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004833 name: PRM1_human def: "Sperm protamine-P1 gene" [UniProtKB:P04553] xref: EMBL:AF215707 xref: EMBL:BC003673 xref: EMBL:BT006746 xref: EMBL:M29706 xref: EMBL:M60331 xref: EMBL:S68144 xref: EMBL:U15422 xref: EMBL:Y00443 xref: EMBL:Z46940 xref: HGNC:HGNC:9447 xref: UniGene:Hs.2909 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001481 ! HSP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004834 name: HSPA1A_human def: "Heat shock 70 kDa protein 1 gene" [UniProtKB:P08107] synonym: "HSPA1" EXACT [UniProtKB:P08107] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005822 ! HSP71_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004835 name: HSPA1B_human def: "Heat shock 70 kDa protein 1 gene" [UniProtKB:P08107] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005822 ! HSP71_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004836 name: HSPA2_human def: "Heat shock-related 70 kDa protein 2 gene" [UniProtKB:P54652] xref: EMBL:BC001752 xref: EMBL:BC036107 xref: EMBL:BT009815 xref: EMBL:DQ489378 xref: EMBL:L26336 xref: EMBL:U10149 xref: EMBL:U56725 xref: HGNC:HGNC:5235 xref: UniGene:Hs.432648 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001670 ! HSP72_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004838 name: HSPA8_human def: "Heat shock cognate 71 kDa protein gene" [UniProtKB:P11142] synonym: "HSC70" EXACT [UniProtKB:P11142] synonym: "HSP73" EXACT [UniProtKB:P11142] synonym: "HSPA10" EXACT [UniProtKB:P11142] xref: EMBL:AB034951 xref: EMBL:AF352832 xref: EMBL:BC016179 xref: EMBL:BC016660 xref: EMBL:BC019816 xref: EMBL:Y00371 xref: HGNC:HGNC:5241 xref: UniGene:Hs.702021 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005699 ! HSP7C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004839 name: HSPB1_human def: "Heat shock protein beta-1 gene" [UniProtKB:P04792] synonym: "HSP27" EXACT [UniProtKB:P04792] xref: EMBL:AB020027 xref: EMBL:AC006388 xref: EMBL:BC000510 xref: EMBL:BC012768 xref: EMBL:BC073768 xref: EMBL:BT019888 xref: EMBL:CR407614 xref: EMBL:CR536489 xref: EMBL:DQ379985 xref: EMBL:L39370 xref: EMBL:S74571 xref: EMBL:U90906 xref: EMBL:X16477 xref: EMBL:X54079 xref: EMBL:Z23090 xref: HGNC:HGNC:5246 xref: UniGene:Hs.520973 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005842 ! HSPB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004840 name: HSPB3_human def: "Heat shock protein beta-3 gene" [UniProtKB:Q12988] synonym: "HSPL27" EXACT [UniProtKB:Q12988] xref: EMBL:U15590 xref: EMBL:Y17782 xref: HGNC:HGNC:5248 xref: UniGene:Hs.41707 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006197 ! HSPB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004841 name: HSPB9_human def: "Heat shock protein beta-9 gene" [UniProtKB:Q9BQS6] xref: EMBL:AJ302068 xref: EMBL:BC093991 xref: EMBL:BC093993 xref: HGNC:HGNC:30589 xref: UniGene:Hs.620611 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005333 ! HSPB9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004842 name: HTATIP2_human def: "Oxidoreductase HTATIP2 gene" [UniProtKB:Q9BUP3] synonym: "CC3" EXACT [UniProtKB:Q9BUP3] synonym: "TIP30" EXACT [UniProtKB:Q9BUP3] xref: EMBL:AF039103 xref: EMBL:AF092095 xref: EMBL:AK222969 xref: EMBL:AK223010 xref: EMBL:BC002439 xref: EMBL:BC015358 xref: EMBL:CR456821 xref: EMBL:U69161 xref: HGNC:HGNC:16637 xref: UniGene:Hs.90753 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002098 ! HTAI2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004843 name: HUS1_human def: "Checkpoint protein HUS1 gene" [UniProtKB:O60921] xref: EMBL:AF076844 xref: EMBL:AF110393 xref: EMBL:AF503165 xref: EMBL:BC007013 xref: EMBL:BT019481 xref: EMBL:BT019482 xref: EMBL:CR536552 xref: EMBL:Y16893 xref: HGNC:HGNC:5309 xref: UniGene:Hs.152983 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001419 ! HUS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004844 name: HUWE1_human def: "E3 ubiquitin-protein ligase HUWE1 gene" [UniProtKB:Q7Z6Z7] synonym: "HSPC272" EXACT [UniProtKB:Q7Z6Z7] synonym: "KIAA0312" EXACT [UniProtKB:Q7Z6Z7] synonym: "KIAA1578" EXACT [UniProtKB:Q7Z6Z7] synonym: "UREB1" EXACT [UniProtKB:Q7Z6Z7] xref: EMBL:AB002310 xref: EMBL:AB046798 xref: EMBL:AB071605 xref: EMBL:AF057569 xref: EMBL:AF161390 xref: EMBL:AL162050 xref: EMBL:AL592046 xref: EMBL:AY772009 xref: EMBL:AY929612 xref: EMBL:BC002602 xref: EMBL:BC063505 xref: EMBL:CR456813 xref: EMBL:DQ097177 xref: EMBL:Z94044 xref: EMBL:Z97054 xref: HGNC:HGNC:30892 xref: UniGene:Hs.136905 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005709 ! HUWE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004845 name: HOXC10_human def: "Homeobox protein Hox-C10 gene" [UniProtKB:Q9NYD6] synonym: "HOX3I" EXACT [UniProtKB:Q9NYD6] xref: EMBL:AF255675 xref: EMBL:BC001293 xref: EMBL:X99684 xref: EMBL:X99685 xref: HGNC:HGNC:5122 xref: UniGene:Hs.44276 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005451 ! HXC10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004847 name: ICAM1_human def: "Intercellular adhesion molecule 1 precursor gene" [UniProtKB:P05362] xref: EMBL:AY225514 xref: EMBL:BC015969 xref: EMBL:BT006854 xref: EMBL:J03132 xref: EMBL:M24283 xref: EMBL:X06990 xref: EMBL:X57151 xref: EMBL:X59286 xref: EMBL:X59287 xref: EMBL:X59288 xref: HGNC:HGNC:5344 xref: UniGene:Hs.643447 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005450 ! ICAM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004848 name: ID2_human def: "DNA-binding protein inhibitor ID-2 gene" [UniProtKB:Q02363] xref: EMBL:BC030639 xref: EMBL:D13891 xref: EMBL:M97796 xref: HGNC:HGNC:5361 xref: UniGene:Hs.180919 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006149 ! ID2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004850 name: IDI2_human def: "Isopentenyl-diphosphate Delta-isomerase 2 gene" [UniProtKB:Q9BXS1] xref: EMBL:AF271725 xref: EMBL:AF271726 xref: EMBL:AF271727 xref: EMBL:AF271728 xref: EMBL:AF271729 xref: EMBL:AF291755 xref: EMBL:AK056950 xref: EMBL:BC017778 xref: HGNC:HGNC:23487 xref: UniGene:Hs.591325 xref: UniGene:Hs.9270 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006021 ! IDI2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004851 name: EIF2S2_human def: "Eukaryotic translation initiation factor 2 subunit 2 gene" [UniProtKB:P20042] synonym: "EIF2B" EXACT [UniProtKB:P20042] xref: EMBL:AL031668 xref: EMBL:BC000461 xref: EMBL:BC000934 xref: EMBL:M29536 xref: HGNC:HGNC:3266 xref: UniGene:Hs.429180 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006090 ! IF2B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004862 name: EIF4A1_human def: "Eukaryotic initiation factor 4A-I gene" [UniProtKB:P60842] synonym: "DDX2A" EXACT [UniProtKB:P60842] synonym: "EIF4A" EXACT [UniProtKB:P60842] xref: EMBL:BC009585 xref: EMBL:BC073752 xref: EMBL:BT019880 xref: EMBL:BT019881 xref: EMBL:D13748 xref: HGNC:HGNC:3282 xref: UniGene:Hs.129673 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005679 ! IF4A1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004863 name: EIF4A2_human def: "Eukaryotic initiation factor 4A-II gene" [UniProtKB:Q14240] synonym: "DDX2B" EXACT [UniProtKB:Q14240] synonym: "EIF4F" EXACT [UniProtKB:Q14240] xref: EMBL:BC012547 xref: EMBL:BC013708 xref: EMBL:BC015842 xref: EMBL:BC048105 xref: EMBL:D30655 xref: HGNC:HGNC:3284 xref: UniGene:Hs.599481 xref: UniGene:Hs.700566 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005728 ! IF4A2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004864 name: EIF4G2_human def: "Eukaryotic translation initiation factor 4 gamma 2 gene" [UniProtKB:P78344] synonym: "DAP5" EXACT [UniProtKB:P78344] synonym: "OK/SW-cl.75" EXACT [UniProtKB:P78344] xref: EMBL:AB063323 xref: EMBL:AK223548 xref: EMBL:BC014930 xref: EMBL:BC018975 xref: EMBL:BC039851 xref: EMBL:BC111415 xref: EMBL:U73824 xref: EMBL:U76111 xref: EMBL:X89713 xref: HGNC:HGNC:3297 xref: UniGene:Hs.183684 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001699 ! IF4G2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004866 name: IFNW1_human def: "Interferon omega-1 precursor gene" [UniProtKB:P05000] xref: EMBL:A12140 xref: EMBL:AL390882 xref: EMBL:AY780805 xref: EMBL:BC069095 xref: EMBL:BC117290 xref: EMBL:BC117292 xref: EMBL:CH471071 xref: EMBL:M11003 xref: EMBL:U25670 xref: EMBL:X02669 xref: EMBL:X58822 xref: HGNC:HGNC:5448 xref: UniGene:Hs.73010 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001484 ! IFNW1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004867 name: IGF1R_human def: "Insulin-like growth factor 1 receptor precursor gene" [UniProtKB:P08069] xref: EMBL:AY332722 xref: EMBL:BC113610 xref: EMBL:BC113612 xref: EMBL:M69229 xref: EMBL:X04434 xref: HGNC:HGNC:5465 xref: UniGene:Hs.643120 xref: UniGene:Hs.653608 xref: UniGene:Hs.698330 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001497 ! IGF1R_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004869 name: IGHA1_human def: "Ig alpha-1 chain C region gene" [UniProtKB:P01876] xref: EMBL:J00220 xref: HGNC:HGNC:5478 xref: UniGene:Hs.648398 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005921 ! IGHA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004870 name: IGSF21_human def: "Immunoglobulin superfamily member 21 precursor gene" [UniProtKB:Q96ID5] xref: EMBL:AK075316 xref: EMBL:AL050342 xref: EMBL:AL356101 xref: EMBL:AL359738 xref: EMBL:AL365209 xref: EMBL:BC007618 xref: HGNC:HGNC:28246 xref: UniGene:Hs.212511 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006168 ! IGS21_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004871 name: NFKBIA_human def: "NF-kappa-B inhibitor alpha gene" [UniProtKB:P25963] synonym: "IKBA" EXACT [UniProtKB:P25963] synonym: "MAD3" EXACT [UniProtKB:P25963] synonym: "NFKBI" EXACT [UniProtKB:P25963] xref: EMBL:AJ249283 xref: EMBL:AJ249284 xref: EMBL:AJ249285 xref: EMBL:AJ249286 xref: EMBL:AJ249294 xref: EMBL:AJ249295 xref: EMBL:AY033600 xref: EMBL:AY496422 xref: EMBL:BC002601 xref: EMBL:BC004983 xref: EMBL:BT007091 xref: EMBL:M69043 xref: HGNC:HGNC:7797 xref: UniGene:Hs.81328 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005521 ! IKBA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004872 name: NFKBIB_human def: "NF-kappa-B inhibitor beta gene" [UniProtKB:Q15653] synonym: "IKBB" EXACT [UniProtKB:Q15653] synonym: "TRIP9" EXACT [UniProtKB:Q15653] xref: EMBL:AY736284 xref: EMBL:BC007197 xref: EMBL:BC015528 xref: EMBL:BT006743 xref: EMBL:L40407 xref: HGNC:HGNC:7798 xref: UniGene:Hs.9731 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005537 ! IKBB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004873 name: NFKBIE_human def: "NF-kappa-B inhibitor epsilon gene" [UniProtKB:O00221] synonym: "IKBE" EXACT [UniProtKB:O00221] xref: EMBL:U91616 xref: HGNC:HGNC:7799 xref: UniGene:Hs.458276 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005538 ! IKBE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004874 name: CHUK_human def: "Inhibitor of nuclear factor kappa-B kinase subunit alpha gene" [UniProtKB:O15111] synonym: "IKKA" EXACT [UniProtKB:O15111] synonym: "TCF16" EXACT [UniProtKB:O15111] xref: EMBL:AF009225 xref: EMBL:AF012890 xref: EMBL:AF080157 xref: EMBL:AL138921 xref: EMBL:AY652653 xref: EMBL:U22512 xref: HGNC:HGNC:1974 xref: UniGene:Hs.198998 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005539 ! IKKA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004875 name: IKBKB_human def: "Inhibitor of nuclear factor kappa-B kinase subunit beta gene" [UniProtKB:O14920] synonym: "IKKB" EXACT [UniProtKB:O14920] xref: EMBL:AF029684 xref: EMBL:AF031416 xref: EMBL:AF080158 xref: EMBL:AY663108 xref: EMBL:BC006231 xref: HGNC:HGNC:5960 xref: UniGene:Hs.656458 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005522 ! IKKB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004876 name: IKBKE_human def: "Inhibitor of nuclear factor kappa-B kinase subunit epsilon gene" [UniProtKB:Q14164] synonym: "IKKE" EXACT [UniProtKB:Q14164] synonym: "IKKI" EXACT [UniProtKB:Q14164] synonym: "KIAA0151" EXACT [UniProtKB:Q14164] xref: EMBL:AB016590 xref: EMBL:AF241789 xref: EMBL:AL354681 xref: EMBL:BC105923 xref: EMBL:BC105924 xref: EMBL:D63485 xref: EMBL:DQ667176 xref: HGNC:HGNC:14552 xref: UniGene:Hs.321045 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005523 ! IKKE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004877 name: IKZF1_human def: "DNA-binding protein Ikaros gene" [UniProtKB:Q13422] synonym: "IK1" EXACT [UniProtKB:Q13422] synonym: "IKAROS" EXACT [UniProtKB:Q13422] synonym: "LYF1" EXACT [UniProtKB:Q13422] synonym: "ZNFN1A1" EXACT [UniProtKB:Q13422] xref: EMBL:BC018349 xref: EMBL:S80876 xref: EMBL:U40462 xref: HGNC:HGNC:13176 xref: UniGene:Hs.435949 xref: UniGene:Hs.488251 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005213 ! IKZF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004880 name: IL1F5_human def: "Interleukin-1 family member 5 gene" [UniProtKB:Q9UBH0] synonym: "FIL1D" EXACT [UniProtKB:Q9UBH0] synonym: "IL1HY1" EXACT [UniProtKB:Q9UBH0] synonym: "IL1L1" EXACT [UniProtKB:Q9UBH0] synonym: "IL1RP3" EXACT [UniProtKB:Q9UBH0] synonym: "UNQ1896/PRO4342" EXACT [UniProtKB:Q9UBH0] xref: EMBL:AC016724 xref: EMBL:AF186094 xref: EMBL:AF201830 xref: EMBL:AF216693 xref: EMBL:AF230377 xref: EMBL:AJ242737 xref: EMBL:AJ242738 xref: EMBL:AJ271338 xref: EMBL:AY359117 xref: EMBL:AY972853 xref: EMBL:BC024747 xref: EMBL:BN000002 xref: HGNC:HGNC:15561 xref: UniGene:Hs.516301 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005205 ! IL1F5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004883 name: IL8_human def: "Interleukin-8 precursor gene" [UniProtKB:P10145] synonym: "CXCL8" EXACT [UniProtKB:P10145] xref: EMBL:AF043337 xref: EMBL:AF385628 xref: EMBL:BC013615 xref: EMBL:BT007067 xref: EMBL:CR542151 xref: EMBL:D14283 xref: EMBL:M17017 xref: EMBL:M26383 xref: EMBL:M28130 xref: EMBL:Y00787 xref: EMBL:Z11686 xref: HGNC:HGNC:6025 xref: UniGene:Hs.551925 xref: UniGene:Hs.561078 xref: UniGene:Hs.624 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001504 ! IL8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004884 name: ILF3_human def: "Interleukin enhancer-binding factor 3 gene" [UniProtKB:Q12906] synonym: "DRBF" EXACT [UniProtKB:Q12906] synonym: "MPHOSPH4" EXACT [UniProtKB:Q12906] synonym: "NF90" EXACT [UniProtKB:Q12906] xref: EMBL:AF007140 xref: EMBL:AF141870 xref: EMBL:AF147209 xref: EMBL:AF167569 xref: EMBL:AF167570 xref: EMBL:AF202445 xref: EMBL:AF320228 xref: EMBL:AF320229 xref: EMBL:AF320230 xref: EMBL:AF320231 xref: EMBL:AF320232 xref: EMBL:AF320233 xref: EMBL:AF320234 xref: EMBL:AF320235 xref: EMBL:AF320236 xref: EMBL:AF320237 xref: EMBL:AF320238 xref: EMBL:AF320239 xref: EMBL:AF320240 xref: EMBL:AF320241 xref: EMBL:AF320242 xref: EMBL:AF320243 xref: EMBL:AF320244 xref: EMBL:AF320245 xref: EMBL:AF320246 xref: EMBL:AF320247 xref: EMBL:AJ271741 xref: EMBL:AJ271744 xref: EMBL:AJ271745 xref: EMBL:AJ271746 xref: EMBL:AJ271747 xref: EMBL:BC048314 xref: EMBL:BC064836 xref: EMBL:U10324 xref: EMBL:X98264 xref: EMBL:X98265 xref: HGNC:HGNC:6038 xref: UniGene:Hs.465885 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001734 ! ILF3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004886 name: KPNA2_human def: "Importin subunit alpha-2 gene" [UniProtKB:P52292] synonym: "RCH1" EXACT [UniProtKB:P52292] synonym: "SRP1" EXACT [UniProtKB:P52292] xref: EMBL:AJ303086 xref: EMBL:BC005978 xref: EMBL:U09559 xref: EMBL:U28386 xref: HGNC:HGNC:6395 xref: UniGene:Hs.594238 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001657 ! IMA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004887 name: KPNA3_human def: "Importin subunit alpha-3 gene" [UniProtKB:O00505] xref: EMBL:AF034756 xref: EMBL:BC017355 xref: EMBL:BC024202 xref: EMBL:D89618 xref: EMBL:Y12394 xref: HGNC:HGNC:6396 xref: UniGene:Hs.527919 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005931 ! IMA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004888 name: KPNA5_human def: "Importin subunit alpha-6 gene" [UniProtKB:O15131] xref: EMBL:AF005361 xref: EMBL:AL132795 xref: EMBL:BC047409 xref: HGNC:HGNC:6398 xref: UniGene:Hs.182971 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005697 ! IMA5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004889 name: KPNB1_human def: "Importin subunit beta-1 gene" [UniProtKB:Q14974] synonym: "NTF97" EXACT [UniProtKB:Q14974] xref: EMBL:BC003572 xref: EMBL:BC024045 xref: EMBL:BC036703 xref: EMBL:L38951 xref: EMBL:L39793 xref: HGNC:HGNC:6400 xref: UniGene:Hs.532793 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005409 ! IMB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004890 name: IMMT_human def: "Mitochondrial inner membrane protein gene" [UniProtKB:Q16891] synonym: "HMP" EXACT [UniProtKB:Q16891] synonym: "PIG4" EXACT [UniProtKB:Q16891] xref: EMBL:AF148646 xref: EMBL:AY232292 xref: EMBL:BC002412 xref: EMBL:BC027458 xref: EMBL:BX537369 xref: EMBL:CR456793 xref: EMBL:CR749590 xref: EMBL:D21091 xref: EMBL:D21092 xref: EMBL:D21093 xref: EMBL:D21094 xref: EMBL:L42572 xref: HGNC:HGNC:6047 xref: UniGene:Hs.148559 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006201 ! IMMT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004891 name: INCENP_human def: "Inner centromere protein gene" [UniProtKB:Q9NQS7] xref: EMBL:AF282265 xref: EMBL:AY714053 xref: EMBL:BC098576 xref: HGNC:HGNC:6058 xref: UniGene:Hs.142179 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002154 ! INCE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004892 name: ING1_human def: "Inhibitor of growth protein 1 gene" [UniProtKB:Q9UK53] xref: EMBL:AB024401 xref: EMBL:AB024402 xref: EMBL:AB024403 xref: EMBL:AB024404 xref: EMBL:AB024405 xref: EMBL:AB031269 xref: EMBL:AB037387 xref: EMBL:AB037594 xref: EMBL:AF001954 xref: EMBL:AF044076 xref: EMBL:AF078835 xref: EMBL:AF078836 xref: EMBL:AF078837 xref: EMBL:AF149721 xref: EMBL:AF149722 xref: EMBL:AF149723 xref: EMBL:AF167549 xref: EMBL:AF167550 xref: EMBL:AF167551 xref: EMBL:AF181849 xref: EMBL:AF181850 xref: EMBL:AJ310392 xref: HGNC:HGNC:6062 xref: UniGene:Hs.46700 xref: UniGene:Hs.508725 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002217 ! ING1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004893 name: ING3_human def: "Inhibitor of growth protein 3 gene" [UniProtKB:Q9NXR8] synonym: "HSPC301" EXACT [UniProtKB:Q9NXR8] xref: EMBL:AC004537 xref: EMBL:AF074968 xref: EMBL:AF161419 xref: EMBL:AK000096 xref: EMBL:AL603623 xref: EMBL:AY007790 xref: EMBL:BC009777 xref: EMBL:BC010851 xref: EMBL:BC062634 xref: EMBL:BC073865 xref: HGNC:HGNC:14587 xref: UniGene:Hs.489811 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005368 ! ING3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004894 name: ING4_human def: "Inhibitor of growth protein 4 gene" [UniProtKB:Q9UNL4] synonym: "My036" EXACT [UniProtKB:Q9UNL4] xref: EMBL:AF063594 xref: EMBL:AF110645 xref: EMBL:AF156552 xref: EMBL:BC007781 xref: EMBL:BC013038 xref: HGNC:HGNC:19423 xref: UniGene:Hs.524210 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002234 ! ING4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004895 name: ING5_human def: "Inhibitor of growth protein 5 gene" [UniProtKB:Q8WYH8] xref: EMBL:AF189286 xref: EMBL:AK074422 xref: EMBL:BC005370 xref: EMBL:BC071899 xref: HGNC:HGNC:19421 xref: UniGene:Hs.529172 xref: UniGene:Hs.645460 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005284 ! ING5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004896 name: INHA_human def: "Inhibin alpha chain precursor gene" [UniProtKB:P05111] xref: EMBL:BC006391 xref: EMBL:BT006954 xref: EMBL:M13144 xref: EMBL:M13981 xref: EMBL:X04445 xref: EMBL:X04446 xref: HGNC:HGNC:6065 xref: UniGene:Hs.407506 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001485 ! INHA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004897 name: INHBA_human def: "Inhibin beta A chain precursor gene" [UniProtKB:P08476] xref: EMBL:AC005027 xref: EMBL:BC007858 xref: EMBL:J03634 xref: EMBL:M13436 xref: EMBL:X04447 xref: EMBL:X57578 xref: EMBL:X57579 xref: EMBL:X72498 xref: HGNC:HGNC:6066 xref: UniGene:Hs.583348 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001498 ! INHBA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004898 name: INOC1_human def: "Putative DNA helicase INO80 complex homolog 1 gene" [UniProtKB:Q9ULG1] synonym: "KIAA1259" EXACT [UniProtKB:Q9ULG1] xref: EMBL:AB033085 xref: EMBL:AL137280 xref: HGNC:HGNC:26956 xref: UniGene:Hs.292949 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006056 ! INOC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004899 name: INPP1_human def: "Inositol polyphosphate 1-phosphatase gene" [UniProtKB:P49441] xref: EMBL:AF141325 xref: EMBL:BC015496 xref: EMBL:L08488 xref: HGNC:HGNC:6071 xref: UniGene:Hs.32309 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006332 ! INPP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004900 name: INSR_human def: "Insulin receptor precursor gene" [UniProtKB:P06213] xref: EMBL:J03466 xref: EMBL:J05043 xref: EMBL:M10051 xref: EMBL:M23100 xref: EMBL:M24555 xref: EMBL:M27195 xref: EMBL:M27197 xref: EMBL:M29929 xref: EMBL:M29930 xref: EMBL:M32823 xref: EMBL:M32824 xref: EMBL:M32825 xref: EMBL:M32826 xref: EMBL:M32827 xref: EMBL:M32828 xref: EMBL:M32829 xref: EMBL:M32830 xref: EMBL:M32831 xref: EMBL:M32832 xref: EMBL:M32833 xref: EMBL:M32834 xref: EMBL:M32835 xref: EMBL:M32836 xref: EMBL:M32837 xref: EMBL:M32838 xref: EMBL:M32839 xref: EMBL:M32840 xref: EMBL:M32841 xref: EMBL:M32842 xref: EMBL:M32972 xref: EMBL:M76592 xref: EMBL:X02160 xref: HGNC:HGNC:6091 xref: UniGene:Hs.465744 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005478 ! INSR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004901 name: IPO7_human def: "Importin-7 gene" [UniProtKB:O95373] synonym: "RANBP7" EXACT [UniProtKB:O95373] xref: EMBL:AC055845 xref: EMBL:AF098799 xref: EMBL:AJ295844 xref: EMBL:AL137335 xref: EMBL:BC114929 xref: EMBL:CH471064 xref: HGNC:HGNC:9852 xref: UniGene:Hs.699345 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005661 ! IPO7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004902 name: PPA1_human def: "Inorganic pyrophosphatase gene" [UniProtKB:Q15181] synonym: "IOPPP" EXACT [UniProtKB:Q15181] synonym: "PP" EXACT [UniProtKB:Q15181] xref: EMBL:AB026723 xref: EMBL:AF092439 xref: EMBL:AF108211 xref: EMBL:AF119665 xref: EMBL:AF154065 xref: EMBL:AF217186 xref: EMBL:AL731540 xref: EMBL:BC001022 xref: EMBL:BC061581 xref: EMBL:BC105034 xref: EMBL:BC105036 xref: EMBL:BC107882 xref: EMBL:Z48605 xref: HGNC:HGNC:9226 xref: UniGene:Hs.437403 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006102 ! IPYR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004903 name: IRF1_human def: "Interferon regulatory factor 1 gene" [UniProtKB:P10914] xref: EMBL:BC009483 xref: EMBL:BT019756 xref: EMBL:L05072 xref: EMBL:X14454 xref: HGNC:HGNC:6116 xref: UniGene:Hs.436061 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001510 ! IRF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004904 name: ITGAE_human def: "Integrin alpha-E precursor gene" [UniProtKB:P38570] xref: EMBL:AF168787 xref: EMBL:BC113436 xref: EMBL:BC117207 xref: EMBL:L25851 xref: HGNC:HGNC:6147 xref: UniGene:Hs.513867 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006318 ! ITAE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004905 name: TCF4_human def: "Transcription factor 4 gene" [UniProtKB:P15884] synonym: "ITF2" EXACT [UniProtKB:P15884] synonym: "SEF2" EXACT [UniProtKB:P15884] xref: EMBL:AV761952 xref: EMBL:BC125084 xref: EMBL:BC125085 xref: EMBL:M74718 xref: EMBL:M74719 xref: EMBL:M74720 xref: EMBL:U75701 xref: EMBL:X52079 xref: HGNC:HGNC:11634 xref: UniGene:Hs.644653 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005715 ! ITF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004907 name: JAG2_human def: "Protein jagged-2 precursor gene" [UniProtKB:Q9Y219] xref: EMBL:AF003521 xref: EMBL:AF020201 xref: EMBL:AF029778 xref: EMBL:AF029779 xref: EMBL:AF111170 xref: EMBL:Y14330 xref: HGNC:HGNC:6189 xref: UniGene:Hs.433445 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002245 ! JAG2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004909 name: JAK3_human def: "Tyrosine-protein kinase JAK3 gene" [UniProtKB:P52333] xref: EMBL:AC007201 xref: EMBL:AF513860 xref: EMBL:U09607 xref: EMBL:U31601 xref: EMBL:U31602 xref: EMBL:U57096 xref: HGNC:HGNC:6193 xref: UniGene:Hs.515247 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005612 ! JAK3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004910 name: FBXL11_human def: "JmjC domain-containing histone demethylation protein 1A gene" [UniProtKB:Q9Y2K7] synonym: "CXXC8" EXACT [UniProtKB:Q9Y2K7] synonym: "FBL7" EXACT [UniProtKB:Q9Y2K7] synonym: "JHDM1A" EXACT [UniProtKB:Q9Y2K7] synonym: "KIAA1004" EXACT [UniProtKB:Q9Y2K7] xref: EMBL:AB023221 xref: EMBL:AF179221 xref: EMBL:AK024505 xref: EMBL:AL117517 xref: EMBL:BC001203 xref: EMBL:BC047371 xref: EMBL:BC047486 xref: EMBL:BC064360 xref: HGNC:HGNC:13606 xref: UniGene:Hs.124147 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006051 ! JHD1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004911 name: MAPK8IP3_human def: "C-jun-amino-terminal kinase-interacting protein 3 gene" [UniProtKB:Q9UPT6] synonym: "JIP3" EXACT [UniProtKB:Q9UPT6] synonym: "KIAA1066" EXACT [UniProtKB:Q9UPT6] xref: EMBL:AB028989 xref: EMBL:AC012180 xref: EMBL:AE006639 xref: EMBL:AK024437 xref: EMBL:AL031710 xref: EMBL:AL031717 xref: EMBL:AL031718 xref: HGNC:HGNC:6884 xref: UniGene:Hs.207763 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006034 ! JIP3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004914 name: KIAA0087_human def: "Uncharacterized protein KIAA0087 gene" [UniProtKB:Q14695] synonym: "HA1002" EXACT [UniProtKB:Q14695] xref: EMBL:D42038 xref: HGNC:HGNC:22191 xref: UniGene:Hs.69749 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006280 ! K0087_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004915 name: KIAA0240_human def: "Uncharacterized protein KIAA0240 gene" [UniProtKB:Q6AI39] xref: EMBL:AL035587 xref: EMBL:AL353716 xref: EMBL:CR627378 xref: EMBL:D87077 xref: HGNC:HGNC:21111 xref: UniGene:Hs.658033 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005596 ! K0240_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004916 name: KIAA1267_human def: "Uncharacterized protein KIAA1267 gene" [UniProtKB:Q7Z3B3] xref: EMBL:AB033093 xref: EMBL:AL117476 xref: EMBL:AL137317 xref: EMBL:BC006271 xref: EMBL:BC035892 xref: EMBL:BC098376 xref: EMBL:BX538006 xref: EMBL:BX648760 xref: HGNC:HGNC:24565 xref: UniGene:Hs.648744 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005600 ! K1267_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004917 name: KIAA1279_human def: "Uncharacterized protein KIAA1279 gene" [UniProtKB:Q96EK5] xref: EMBL:AB033105 xref: EMBL:AL050190 xref: EMBL:AL359844 xref: EMBL:BC012180 xref: HGNC:HGNC:23419 xref: UniGene:Hs.279580 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005627 ! K1279_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004918 name: KIAA1377_human def: "Uncharacterized protein KIAA1377 gene" [UniProtKB:Q9P2H0] xref: EMBL:AB037798 xref: EMBL:AP003383 xref: HGNC:HGNC:29264 xref: UniGene:Hs.156352 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005403 ! K1377_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004920 name: KRT14_human def: "Keratin, type I cytoskeletal 14 gene" [UniProtKB:P02533] xref: EMBL:AF186085 xref: EMBL:AF186086 xref: EMBL:AF186087 xref: EMBL:AF186088 xref: EMBL:AF186089 xref: EMBL:AF186090 xref: EMBL:BC002690 xref: EMBL:BC019097 xref: EMBL:BC042437 xref: EMBL:BC094830 xref: EMBL:BT007186 xref: EMBL:D28807 xref: EMBL:J00124 xref: HGNC:HGNC:6416 xref: UniGene:Hs.654380 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005817 ! K1C14_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004921 name: KRT15_human def: "Keratin, type I cytoskeletal 15 gene" [UniProtKB:P19012] synonym: "KRTB" EXACT [UniProtKB:P19012] xref: EMBL:AF202320 xref: EMBL:BC002641 xref: EMBL:BT007261 xref: EMBL:X07696 xref: HGNC:HGNC:6421 xref: UniGene:Hs.654570 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005207 ! K1C15_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004922 name: KRT17_human def: "Keratin, type I cytoskeletal 17 gene" [UniProtKB:Q04695] xref: EMBL:AC022596 xref: EMBL:AK095342 xref: EMBL:AL353997 xref: EMBL:BC000159 xref: EMBL:BC011901 xref: EMBL:BC056421 xref: EMBL:BC072018 xref: EMBL:BC072019 xref: EMBL:EF608068 xref: EMBL:EF608069 xref: EMBL:EF608070 xref: EMBL:EF608071 xref: EMBL:S78515 xref: EMBL:X62571 xref: EMBL:Z19574 xref: HGNC:HGNC:6427 xref: UniGene:Hs.2785 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005844 ! K1C17_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004923 name: KRT18_human def: "Keratin, type I cytoskeletal 18 gene" [UniProtKB:P05783] synonym: "CYK18" EXACT [UniProtKB:P05783] synonym: "PIG46" EXACT [UniProtKB:P05783] xref: EMBL:AF179904 xref: EMBL:AK223093 xref: EMBL:AY762101 xref: EMBL:BC000180 xref: EMBL:BC000698 xref: EMBL:BC004253 xref: EMBL:BC008636 xref: EMBL:BC020982 xref: EMBL:BC072017 xref: EMBL:BT019412 xref: EMBL:X12876 xref: EMBL:X12881 xref: EMBL:X12883 xref: HGNC:HGNC:6430 xref: UniGene:Hs.406013 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001489 ! K1C18_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004924 name: KRT9_human def: "Keratin, type I cytoskeletal 9 gene" [UniProtKB:P35527] xref: EMBL:AB001594 xref: EMBL:BC121170 xref: EMBL:S69510 xref: EMBL:X75015 xref: EMBL:Z29074 xref: HGNC:HGNC:6447 xref: UniGene:Hs.654569 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005922 ! K1C9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004925 name: KRT1_human def: "Keratin, type II cytoskeletal 1 gene" [UniProtKB:P04264] synonym: "KRTA" EXACT [UniProtKB:P04264] xref: EMBL:AF237621 xref: EMBL:AF304164 xref: EMBL:BC063697 xref: EMBL:M10938 xref: EMBL:M98776 xref: HGNC:HGNC:6412 xref: UniGene:Hs.80828 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005823 ! K2C1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004926 name: KRT5_human def: "Keratin, type II cytoskeletal 5 gene" [UniProtKB:P13647] xref: EMBL:AF274874 xref: EMBL:AY373434 xref: EMBL:BC024292 xref: EMBL:BC042132 xref: EMBL:BC071906 xref: EMBL:M19723 xref: EMBL:M21389 xref: EMBL:M28496 xref: HGNC:HGNC:6442 xref: UniGene:Hs.433845 xref: UniGene:Hs.694210 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005811 ! K2C5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004927 name: KRT6A_human def: "Keratin, type II cytoskeletal 6A gene" [UniProtKB:P02538] synonym: "K6A" EXACT [UniProtKB:P02538] synonym: "KRT6D" EXACT [UniProtKB:P02538] xref: EMBL:BC008807 xref: EMBL:BC014152 xref: EMBL:BC069269 xref: EMBL:BC125058 xref: EMBL:BT006899 xref: EMBL:L42575 xref: EMBL:L42576 xref: EMBL:L42577 xref: EMBL:L42578 xref: EMBL:L42579 xref: EMBL:L42580 xref: EMBL:L42581 xref: EMBL:L42583 xref: EMBL:L42603 xref: EMBL:L42604 xref: EMBL:L42605 xref: EMBL:L42606 xref: EMBL:L42607 xref: EMBL:L42608 xref: EMBL:L42609 xref: EMBL:L42610 xref: EMBL:V01516 xref: HGNC:HGNC:6443 xref: UniGene:Hs.433845 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005821 ! K2C6A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004928 name: KRT7_human def: "Keratin, type II cytoskeletal 7 gene" [UniProtKB:P08729] synonym: "SCL" EXACT [UniProtKB:P08729] xref: EMBL:AF509887 xref: EMBL:AF509891 xref: EMBL:AF509892 xref: EMBL:AJ238246 xref: EMBL:BC002700 xref: EMBL:X03212 xref: EMBL:X13320 xref: EMBL:X13346 xref: EMBL:X13347 xref: EMBL:X13348 xref: EMBL:X13349 xref: EMBL:X13350 xref: EMBL:X13351 xref: EMBL:X13352 xref: EMBL:X13353 xref: HGNC:HGNC:6445 xref: UniGene:Hs.411501 xref: UniGene:Hs.670221 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001501 ! K2C7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004929 name: KRT8_human def: "Keratin, type II cytoskeletal 8 gene" [UniProtKB:P05787] synonym: "CYK8" EXACT [UniProtKB:P05787] xref: EMBL:AK222941 xref: EMBL:BC000654 xref: EMBL:BC063513 xref: EMBL:BC073760 xref: EMBL:BC075839 xref: EMBL:M26512 xref: EMBL:M34225 xref: EMBL:M34482 xref: EMBL:U76549 xref: EMBL:X12882 xref: EMBL:X74929 xref: EMBL:X74981 xref: EMBL:X98614 xref: HGNC:HGNC:6446 xref: UniGene:Hs.533782 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005900 ! K2C8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004930 name: PRKAR1A_human def: "cAMP-dependent protein kinase type I-alpha regulatory subunit gene" [UniProtKB:P10644] synonym: "PKR1" EXACT [UniProtKB:P10644] synonym: "PRKAR1" EXACT [UniProtKB:P10644] synonym: "TSE1" EXACT [UniProtKB:P10644] xref: EMBL:BC036285 xref: EMBL:BC093042 xref: EMBL:M18468 xref: EMBL:M33336 xref: EMBL:S54705 xref: EMBL:S54707 xref: EMBL:S54709 xref: EMBL:S54711 xref: EMBL:Y07642 xref: HGNC:HGNC:9388 xref: UniGene:Hs.280342 xref: UniGene:Hs.659124 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005298 ! KAP0_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004931 name: KBTBD7_human def: "Kelch repeat and BTB domain-containing protein 7 gene" [UniProtKB:Q8WVZ9] xref: EMBL:AK091344 xref: EMBL:AL136782 xref: EMBL:AL354696 xref: EMBL:BC022033 xref: EMBL:CH471075 xref: HGNC:HGNC:25266 xref: UniGene:Hs.63841 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005401 ! KBTB7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004932 name: CSNK1E_human def: "Casein kinase I isoform epsilon gene" [UniProtKB:P49674] xref: EMBL:AB024597 xref: EMBL:AB091043 xref: EMBL:AL020993 xref: EMBL:BC006490 xref: EMBL:CR456429 xref: EMBL:L37043 xref: HGNC:HGNC:2453 xref: UniGene:Hs.474833 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005272 ! KC1E_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004933 name: KCTD11_human def: "BTB/POZ domain-containing protein KCTD11 gene" [UniProtKB:Q693B1] synonym: "C17orf36" EXACT [UniProtKB:Q693B1] synonym: "REN" EXACT [UniProtKB:Q693B1] xref: EMBL:AY646650 xref: EMBL:BC110598 xref: HGNC:HGNC:21302 xref: UniGene:Hs.592112 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001904 ! KCD11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004934 name: KCNRG_human def: "Putative potassium channel regulatory protein gene" [UniProtKB:Q8N5I3] synonym: "CLLD4" EXACT [UniProtKB:Q8N5I3] xref: EMBL:AL832695 xref: EMBL:AY129653 xref: EMBL:AY129654 xref: EMBL:AY169387 xref: EMBL:AY169388 xref: EMBL:AY190921 xref: EMBL:AY190922 xref: EMBL:BC032343 xref: HGNC:HGNC:18893 xref: UniGene:Hs.436922 xref: UniGene:Hs.660161 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005217 ! KCNRG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004935 name: CKMT2_human def: "Creatine kinase, sarcomeric mitochondrial precursor gene" [UniProtKB:P17540] xref: EMBL:BC029140 xref: EMBL:CR450315 xref: EMBL:J05401 xref: HGNC:HGNC:1996 xref: UniGene:Hs.80691 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006131 ! KCRS_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004937 name: KHDRBS1_human def: "KH domain-containing, RNA-binding, signal transduction-associated protein 1 gene" [UniProtKB:Q07666] synonym: "SAM68" EXACT [UniProtKB:Q07666] xref: EMBL:AK091346 xref: EMBL:AL139249 xref: EMBL:AL445248 xref: EMBL:BC000717 xref: EMBL:BC010132 xref: EMBL:BC019109 xref: EMBL:M88108 xref: EMBL:U78971 xref: HGNC:HGNC:18116 xref: UniGene:Hs.445893 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001722 ! KHDR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004938 name: KHDRBS3_human def: "KH domain-containing, RNA-binding, signal transduction-associated protein 3 gene" [UniProtKB:O75525] synonym: "SALP" EXACT [UniProtKB:O75525] synonym: "SLM2" EXACT [UniProtKB:O75525] xref: EMBL:AF051321 xref: EMBL:AF051322 xref: EMBL:AF069681 xref: EMBL:BC032606 xref: EMBL:BC068536 xref: HGNC:HGNC:18117 xref: UniGene:Hs.444558 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005275 ! KHDR3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004939 name: KIF13B_human def: "Kinesin-like protein KIF13B gene" [UniProtKB:Q9NQT8] synonym: "GAKIN" EXACT [UniProtKB:Q9NQT8] synonym: "KIAA0639" EXACT [UniProtKB:Q9NQT8] xref: EMBL:AB014539 xref: EMBL:AF279865 xref: EMBL:AL583912 xref: HGNC:HGNC:14405 xref: UniGene:Hs.444767 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005849 ! KI13B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004940 name: MKI67_human def: "Antigen KI-67 gene" [UniProtKB:P46013] xref: EMBL:AL355529 xref: EMBL:AL390236 xref: EMBL:X65550 xref: EMBL:X65551 xref: EMBL:X94762 xref: HGNC:HGNC:7107 xref: UniGene:Hs.80976 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001622 ! KI67_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004941 name: KIF11_human def: "Kinesin-like protein KIF11 gene" [UniProtKB:P52732] synonym: "EG5" EXACT [UniProtKB:P52732] synonym: "KNSL1" EXACT [UniProtKB:P52732] synonym: "TRIP5" EXACT [UniProtKB:P52732] xref: EMBL:AL356128 xref: EMBL:AL360222 xref: EMBL:BC126211 xref: EMBL:L40372 xref: EMBL:U37426 xref: EMBL:X85137 xref: HGNC:HGNC:6388 xref: UniGene:Hs.8878 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001659 ! KIF11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004942 name: KIF17_human def: "Kinesin-like protein KIF17 gene" [UniProtKB:Q9P2E2] synonym: "KIAA1405" EXACT [UniProtKB:Q9P2E2] synonym: "KIF3X" EXACT [UniProtKB:Q9P2E2] xref: EMBL:AB037826 xref: EMBL:AF009624 xref: EMBL:AL391357 xref: EMBL:AL663074 xref: EMBL:AY484427 xref: EMBL:BC036871 xref: EMBL:BC065927 xref: HGNC:HGNC:19167 xref: UniGene:Hs.130411 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005966 ! KIF17_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004943 name: KIF22_human def: "Kinesin-like protein KIF22 gene" [UniProtKB:Q14807] synonym: "KID" EXACT [UniProtKB:Q14807] synonym: "KNSL4" EXACT [UniProtKB:Q14807] xref: EMBL:AB017335 xref: EMBL:AB017430 xref: EMBL:BC004352 xref: EMBL:BC028155 xref: EMBL:BT007259 xref: HGNC:HGNC:6391 xref: UniGene:Hs.613351 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001792 ! KIF22_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004944 name: KIF23_human def: "Kinesin-like protein KIF23 gene" [UniProtKB:Q02241] synonym: "KNSL5" EXACT [UniProtKB:Q02241] synonym: "MKLP1" EXACT [UniProtKB:Q02241] xref: EMBL:BC017705 xref: EMBL:BC051826 xref: EMBL:X67155 xref: HGNC:HGNC:6392 xref: UniGene:Hs.270845 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001716 ! KIF23_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004945 name: KIF25_human def: "Kinesin-like protein KIF25 gene" [UniProtKB:Q9UIL4] synonym: "KNSL3" EXACT [UniProtKB:Q9UIL4] xref: EMBL:AB012722 xref: EMBL:AB012723 xref: EMBL:AL589733 xref: HGNC:HGNC:6390 xref: UniGene:Hs.150013 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002208 ! KIF25_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004946 name: KIF2B_human def: "Kinesin-like protein KIF2B gene" [UniProtKB:Q8N4N8] xref: EMBL:AF333335 xref: EMBL:AK057272 xref: EMBL:BC033802 xref: HGNC:HGNC:29443 xref: UniGene:Hs.226805 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001963 ! KIF2B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004947 name: KIF2C_human def: "Kinesin-like protein KIF2C gene" [UniProtKB:Q99661] synonym: "KNSL6" EXACT [UniProtKB:Q99661] xref: EMBL:AY026505 xref: EMBL:BC008764 xref: EMBL:BC014924 xref: EMBL:U63743 xref: HGNC:HGNC:6393 xref: UniGene:Hs.69360 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002080 ! KIF2C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004948 name: KIF3A_human def: "Kinesin-like protein KIF3A gene" [UniProtKB:Q9Y496] synonym: "KIF3" EXACT [UniProtKB:Q9Y496] xref: EMBL:AB209780 xref: EMBL:AC004237 xref: EMBL:AF041853 xref: EMBL:BC045542 xref: HGNC:HGNC:6319 xref: UniGene:Hs.43670 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005880 ! KIF3A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004949 name: KIF3C_human def: "Kinesin-like protein KIF3C gene" [UniProtKB:O14782] xref: EMBL:AF018164 xref: EMBL:AF035621 xref: EMBL:AJ002223 xref: EMBL:AJ002224 xref: EMBL:AJ002225 xref: EMBL:AJ002226 xref: EMBL:AJ002227 xref: EMBL:AJ002228 xref: EMBL:AJ002229 xref: EMBL:BC092406 xref: EMBL:BC130423 xref: HGNC:HGNC:6321 xref: UniGene:Hs.21611 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005598 ! KIF3C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004950 name: KIF5A_human def: "Kinesin heavy chain isoform 5A gene" [UniProtKB:Q12840] synonym: "NKHC1" EXACT [UniProtKB:Q12840] xref: EMBL:AB210045 xref: EMBL:U06698 xref: HGNC:HGNC:6323 xref: UniGene:Hs.151219 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006166 ! KIF5A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004951 name: KIFC1_human def: "Kinesin-like protein KIFC1 gene" [UniProtKB:Q9BW19] synonym: "HSET" EXACT [UniProtKB:Q9BW19] synonym: "KNSL2" EXACT [UniProtKB:Q9BW19] xref: EMBL:AJ010479 xref: EMBL:AL021366 xref: EMBL:AL050332 xref: EMBL:AL662799 xref: EMBL:BC000712 xref: EMBL:BC063567 xref: EMBL:BC073878 xref: EMBL:BC098438 xref: EMBL:BC121041 xref: EMBL:BC121042 xref: EMBL:BX088650 xref: EMBL:BX248088 xref: EMBL:D14678 xref: HGNC:HGNC:6389 xref: UniGene:Hs.436912 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002105 ! KIFC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004952 name: KIF5B_human def: "Kinesin-1 heavy chain gene" [UniProtKB:P33176] synonym: "KNS" EXACT [UniProtKB:P33176] synonym: "KNS1" EXACT [UniProtKB:P33176] xref: EMBL:AL161932 xref: EMBL:BC126279 xref: EMBL:BC126281 xref: EMBL:X65873 xref: HGNC:HGNC:6324 xref: UniGene:Hs.644646 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005599 ! KINH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004953 name: TK1_human def: "Thymidine kinase, cytosolic gene" [UniProtKB:P04183] xref: EMBL:BC006484 xref: EMBL:BC007872 xref: EMBL:BC007986 xref: EMBL:BT006941 xref: EMBL:K02581 xref: EMBL:M13643 xref: EMBL:M15205 xref: HGNC:HGNC:11830 xref: UniGene:Hs.515122 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006114 ! KITH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004954 name: KLK10_human def: "Kallikrein-10 precursor gene" [UniProtKB:O43240] synonym: "NES1" EXACT [UniProtKB:O43240] synonym: "PRSSL1" EXACT [UniProtKB:O43240] xref: EMBL:AC011473 xref: EMBL:AF024605 xref: EMBL:AF055481 xref: EMBL:AF243527 xref: EMBL:BC002710 xref: HGNC:HGNC:6358 xref: UniGene:Hs.275464 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001383 ! KLK10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004955 name: KNTC1_human def: "Kinetochore-associated protein 1 gene" [UniProtKB:P50748] synonym: "KIAA0166" EXACT [UniProtKB:P50748] xref: EMBL:D79988 xref: HGNC:HGNC:17255 xref: UniGene:Hs.300559 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001645 ! KNTC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004958 name: PRKCI_human def: "Protein kinase C iota type gene" [UniProtKB:P41743] synonym: "DXS1179E" EXACT [UniProtKB:P41743] xref: EMBL:BC022016 xref: EMBL:L18964 xref: EMBL:L33881 xref: HGNC:HGNC:9404 xref: UniGene:Hs.478199 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005173 ! KPCI_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004959 name: PRKCZ_human def: "Protein kinase C zeta type gene" [UniProtKB:Q05513] synonym: "PKC2" EXACT [UniProtKB:Q05513] xref: EMBL:AL391845 xref: EMBL:AL590822 xref: EMBL:AL645703 xref: EMBL:BC008058 xref: EMBL:BC014270 xref: EMBL:BT007082 xref: EMBL:L14283 xref: EMBL:Z15108 xref: HGNC:HGNC:9412 xref: UniGene:Hs.496255 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005315 ! KPCZ_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004960 name: KRTAP4-12_human def: "Keratin-associated protein 4-12 gene" [UniProtKB:Q9BQ66] synonym: "KAP4.12" EXACT [UniProtKB:Q9BQ66] synonym: "KRTAP4.12" EXACT [UniProtKB:Q9BQ66] xref: EMBL:AJ406943 xref: EMBL:BC004180 xref: EMBL:BC004212 xref: EMBL:BC101159 xref: EMBL:BC101160 xref: EMBL:BC101162 xref: HGNC:HGNC:16776 xref: UniGene:Hs.572443 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005293 ! KR412_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004961 name: RPS6KA4_human def: "Ribosomal protein S6 kinase alpha-4 gene" [UniProtKB:O75676] synonym: "MSK2" EXACT [UniProtKB:O75676] xref: EMBL:AF074715 xref: EMBL:AJ010119 xref: EMBL:AK223561 xref: HGNC:HGNC:10433 xref: UniGene:Hs.105584 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005629 ! KS6A4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004963 name: KATNA1_human def: "Katanin p60 ATPase-containing subunit A1 gene" [UniProtKB:O75449] xref: EMBL:AF056022 xref: EMBL:AL078581 xref: EMBL:BC050428 xref: EMBL:BX276089 xref: HGNC:HGNC:6216 xref: UniGene:Hs.450175 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001427 ! KTNA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004964 name: KATNB1_human def: "Katanin p80 WD40-containing subunit B1 gene" [UniProtKB:Q9BVA0] xref: EMBL:AC092118 xref: EMBL:AF052432 xref: EMBL:BC001353 xref: EMBL:BT007022 xref: EMBL:CH471092 xref: EMBL:CR456762 xref: HGNC:HGNC:6217 xref: UniGene:Hs.275675 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002100 ! KTNB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004965 name: XRCC6_human def: "ATP-dependent DNA helicase 2 subunit 1 gene" [UniProtKB:P12956] synonym: "G22P1" EXACT [UniProtKB:P12956] xref: EMBL:AY870329 xref: EMBL:BC008343 xref: EMBL:BC010034 xref: EMBL:BC012154 xref: EMBL:BC018259 xref: EMBL:BC072449 xref: EMBL:CR542219 xref: EMBL:J04607 xref: EMBL:J04611 xref: EMBL:M32865 xref: EMBL:S38729 xref: EMBL:Z83840 xref: HGNC:HGNC:4055 xref: UniGene:Hs.292493 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005410 ! KU70_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004967 name: LLGL2_human def: "Lethal(2) giant larvae protein homolog 2 gene" [UniProtKB:Q6P1M3] xref: EMBL:BC006503 xref: EMBL:BC010879 xref: EMBL:BC064994 xref: EMBL:X87342 xref: HGNC:HGNC:6629 xref: UniGene:Hs.514477 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001913 ! L2GL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004968 name: LAMA4_human def: "Laminin subunit alpha-4 precursor gene" [UniProtKB:Q16363] xref: EMBL:AB210027 xref: EMBL:AL590106 xref: EMBL:S78569 xref: EMBL:X70904 xref: EMBL:X76939 xref: EMBL:X91171 xref: EMBL:Y14240 xref: EMBL:Z99289 xref: HGNC:HGNC:6484 xref: UniGene:Hs.654572 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006093 ! LAMA4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004969 name: LAMB1_human def: "Laminin subunit beta-1 precursor gene" [UniProtKB:P07942] xref: EMBL:BC113455 xref: EMBL:CH236947 xref: EMBL:M20206 xref: EMBL:M55344 xref: EMBL:M55345 xref: EMBL:M55346 xref: EMBL:M55347 xref: EMBL:M55348 xref: EMBL:M55349 xref: EMBL:M55350 xref: EMBL:M55351 xref: EMBL:M55352 xref: EMBL:M55353 xref: EMBL:M55355 xref: EMBL:M55356 xref: EMBL:M55357 xref: EMBL:M55358 xref: EMBL:M55359 xref: EMBL:M55360 xref: EMBL:M55361 xref: EMBL:M55362 xref: EMBL:M55363 xref: EMBL:M55364 xref: EMBL:M55365 xref: EMBL:M55366 xref: EMBL:M55367 xref: EMBL:M55368 xref: EMBL:M55369 xref: EMBL:M55370 xref: EMBL:M55371 xref: EMBL:M55372 xref: EMBL:M55373 xref: EMBL:M55374 xref: EMBL:M55375 xref: EMBL:M55376 xref: EMBL:M55378 xref: EMBL:M58147 xref: EMBL:M61916 xref: EMBL:M61917 xref: EMBL:M61918 xref: EMBL:M61921 xref: EMBL:M61922 xref: EMBL:M61923 xref: EMBL:M61924 xref: EMBL:M61925 xref: EMBL:M61926 xref: EMBL:M61927 xref: EMBL:M61928 xref: EMBL:M61929 xref: EMBL:M61930 xref: EMBL:M61931 xref: EMBL:M61932 xref: EMBL:M61933 xref: EMBL:M61934 xref: EMBL:M61935 xref: EMBL:M61936 xref: EMBL:M61938 xref: EMBL:M61939 xref: EMBL:M61940 xref: EMBL:M61941 xref: EMBL:M61942 xref: EMBL:M61943 xref: EMBL:M61944 xref: EMBL:M61945 xref: EMBL:M61946 xref: EMBL:M61947 xref: EMBL:M61948 xref: EMBL:M61949 xref: EMBL:M61950 xref: EMBL:M61951 xref: HGNC:HGNC:6486 xref: UniGene:Hs.650585 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005967 ! LAMB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004970 name: ERBB2IP_human def: "Protein LAP2 gene" [UniProtKB:Q96RT1] synonym: "ERBIN" EXACT [UniProtKB:Q96RT1] synonym: "KIAA1225" EXACT [UniProtKB:Q96RT1] synonym: "LAP2" EXACT [UniProtKB:Q96RT1] xref: EMBL:AB033051 xref: EMBL:AF263744 xref: EMBL:AF276423 xref: EMBL:AK001180 xref: EMBL:BC050692 xref: HGNC:HGNC:15842 xref: UniGene:Hs.591774 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002059 ! LAP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004971 name: LATS1_human def: "Serine/threonine-protein kinase LATS1 gene" [UniProtKB:O95835] synonym: "WARTS" EXACT [UniProtKB:O95835] xref: EMBL:AF104413 xref: EMBL:AF164041 xref: EMBL:BC002767 xref: HGNC:HGNC:6514 xref: UniGene:Hs.549084 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001454 ! LATS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004972 name: LATS2_human def: "Serine/threonine-protein kinase LATS2 gene" [UniProtKB:Q9NRM7] synonym: "KPM" EXACT [UniProtKB:Q9NRM7] xref: EMBL:AB028019 xref: EMBL:AF207547 xref: HGNC:HGNC:6515 xref: UniGene:Hs.78960 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002159 ! LATS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004973 name: LUC7L2_human def: "Putative RNA-binding protein Luc7-like 2 gene" [UniProtKB:Q9Y383] synonym: "CGI-59" EXACT [UniProtKB:Q9Y383] synonym: "CGI-74" EXACT [UniProtKB:Q9Y383] xref: EMBL:AF151817 xref: EMBL:AF151832 xref: EMBL:AK001476 xref: EMBL:AK001519 xref: EMBL:AK022895 xref: EMBL:BC017163 xref: EMBL:BC042625 xref: EMBL:BC050708 xref: EMBL:BC056886 xref: HGNC:HGNC:21608 xref: UniGene:Hs.370475 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006150 ! LC7L2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004974 name: LCK_human def: "Proto-oncogene tyrosine-protein kinase LCK gene" [UniProtKB:P06239] xref: EMBL:AF228313 xref: EMBL:AL121991 xref: EMBL:BC013200 xref: EMBL:M21510 xref: EMBL:M26692 xref: EMBL:M36881 xref: EMBL:U07236 xref: EMBL:U23852 xref: EMBL:X04476 xref: EMBL:X05027 xref: EMBL:X06369 xref: EMBL:X13529 xref: EMBL:X14053 xref: EMBL:X14054 xref: EMBL:X14055 xref: HGNC:HGNC:6524 xref: UniGene:Hs.470627 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001490 ! LCK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004975 name: LDOC1_human def: "Protein LDOC1 gene" [UniProtKB:O95751] synonym: "BCUR1" EXACT [UniProtKB:O95751] xref: EMBL:AB019527 xref: EMBL:AL109799 xref: EMBL:BC003104 xref: EMBL:CR457088 xref: HGNC:HGNC:6548 xref: UniGene:Hs.45231 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005202 ! LDOC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004976 name: LEPR_human def: "Leptin receptor precursor gene" [UniProtKB:P48357] synonym: "DB" EXACT [UniProtKB:P48357] synonym: "OBR" EXACT [UniProtKB:P48357] xref: EMBL:U43168 xref: EMBL:U50748 xref: EMBL:U52912 xref: EMBL:U52913 xref: EMBL:U52914 xref: EMBL:U59248 xref: EMBL:U59249 xref: EMBL:U59250 xref: EMBL:U59252 xref: EMBL:U59253 xref: EMBL:U59254 xref: EMBL:U59255 xref: EMBL:U59256 xref: EMBL:U59257 xref: EMBL:U59258 xref: EMBL:U59259 xref: EMBL:U59260 xref: EMBL:U59261 xref: EMBL:U59262 xref: EMBL:U59263 xref: EMBL:U66495 xref: EMBL:U66496 xref: EMBL:U66497 xref: HGNC:HGNC:6554 xref: UniGene:Hs.705413 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005902 ! LEPR_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004977 name: DLEU1_human def: "Leukemia-associated protein 1 gene" [UniProtKB:O43261] synonym: "LEU1" EXACT [UniProtKB:O43261] xref: EMBL:AF328925 xref: EMBL:AL137060 xref: EMBL:BC020692 xref: EMBL:Y15227 xref: EMBL:Y15381 xref: HGNC:HGNC:13747 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001385 ! LEU1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004978 name: DLEU2_human def: "Leukemia-associated protein 2 gene" [UniProtKB:O43262] synonym: "LEU2" EXACT [UniProtKB:O43262] xref: EMBL:Y15228 xref: HGNC:HGNC:13748 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001386 ! LEU2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004979 name: LOH11CR2A_human def: "Loss of heterozygosity 11 chromosomal region 2 gene A protein gene" [UniProtKB:O00534] synonym: "BCSC1" EXACT [UniProtKB:O00534] xref: EMBL:AF002672 xref: EMBL:AY366501 xref: EMBL:AY366503 xref: EMBL:AY366504 xref: EMBL:AY366505 xref: EMBL:AY366506 xref: EMBL:AY366507 xref: EMBL:AY366508 xref: EMBL:BC001234 xref: EMBL:BT006655 xref: HGNC:HGNC:6658 xref: UniGene:Hs.152944 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001350 ! LHR2A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004980 name: LIMK1_human def: "LIM domain kinase 1 gene" [UniProtKB:P53667] synonym: "LIMK" EXACT [UniProtKB:P53667] xref: EMBL:AC005056 xref: EMBL:AC005057 xref: EMBL:AF134379 xref: EMBL:D26309 xref: EMBL:U62293 xref: EMBL:U63721 xref: HGNC:HGNC:6613 xref: UniGene:Hs.647035 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005606 ! LIMK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004981 name: LIN9_human def: "Lin-9 homolog gene" [UniProtKB:Q5TKA1] synonym: "BARA" EXACT [UniProtKB:Q5TKA1] synonym: "TGS" EXACT [UniProtKB:Q5TKA1] xref: EMBL:AF190323 xref: EMBL:AF190324 xref: EMBL:AK126177 xref: EMBL:AY786184 xref: EMBL:BC043444 xref: EMBL:BC045625 xref: EMBL:BX537869 xref: HGNC:HGNC:30830 xref: UniGene:Hs.120817 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001894 ! LIN9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004982 name: PPFIA2_human def: "Liprin-alpha-2 gene" [UniProtKB:O75334] xref: EMBL:AF034799 xref: HGNC:HGNC:9246 xref: UniGene:Hs.506216 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005602 ! LIPA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004983 name: PAFAH1B1_human def: "Platelet-activating factor acetylhydrolase IB subunit alpha gene" [UniProtKB:P43034] synonym: "LIS1" EXACT [UniProtKB:P43034] synonym: "MDCR" EXACT [UniProtKB:P43034] synonym: "MDS" EXACT [UniProtKB:P43034] synonym: "PAFAHA" EXACT [UniProtKB:P43034] xref: EMBL:AF208837 xref: EMBL:AF208838 xref: EMBL:AF400434 xref: EMBL:BC064638 xref: EMBL:BX538346 xref: EMBL:L13385 xref: EMBL:L13386 xref: EMBL:L13387 xref: EMBL:U72334 xref: EMBL:U72335 xref: EMBL:U72336 xref: EMBL:U72337 xref: EMBL:U72338 xref: EMBL:U72339 xref: EMBL:U72340 xref: EMBL:U72341 xref: EMBL:U72342 xref: HGNC:HGNC:8574 xref: UniGene:Hs.77318 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001618 ! LIS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004984 name: LMLN_human def: "Leishmanolysin-like peptidase gene" [UniProtKB:Q96KR4] xref: EMBL:AJ312398 xref: EMBL:AJ312399 xref: HGNC:HGNC:15991 xref: UniGene:Hs.518540 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002047 ! LMLN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004985 name: LNX1_human def: "E3 ubiquitin-protein ligase LNX gene" [UniProtKB:Q8TBB1] synonym: "LNX" EXACT [UniProtKB:Q8TBB1] synonym: "UNQ574/PRO1136" EXACT [UniProtKB:Q8TBB1] xref: EMBL:AC058822 xref: EMBL:AC095040 xref: EMBL:AF237782 xref: EMBL:AK056823 xref: EMBL:AY358326 xref: EMBL:BC022983 xref: EMBL:BC034737 xref: HGNC:HGNC:6657 xref: UniGene:Hs.655269 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005305 ! LNX1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004986 name: PPAP2B_human def: "Lipid phosphate phosphohydrolase 3 gene" [UniProtKB:O14495] synonym: "LPP3" EXACT [UniProtKB:O14495] xref: EMBL:AB000889 xref: EMBL:AF017786 xref: EMBL:AF043329 xref: EMBL:AF480883 xref: EMBL:BC009196 xref: EMBL:U79294 xref: HGNC:HGNC:9229 xref: UniGene:Hs.405156 xref: UniGene:Hs.702862 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006019 ! LPP3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004987 name: LRPPRC_human def: "Leucine-rich PPR motif-containing protein, mitochondrial precursor gene" [UniProtKB:P42704] synonym: "LRP130" EXACT [UniProtKB:P42704] xref: EMBL:AK125781 xref: EMBL:AY289212 xref: EMBL:BC050311 xref: EMBL:BC130285 xref: EMBL:M92439 xref: HGNC:HGNC:15714 xref: UniGene:Hs.368084 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005755 ! LPPRC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004988 name: LRRC59_human def: "Leucine-rich repeat-containing protein 59 gene" [UniProtKB:Q96AG4] synonym: "PRO1855" EXACT [UniProtKB:Q96AG4] xref: EMBL:AF119857 xref: EMBL:BC017168 xref: EMBL:BC052279 xref: HGNC:HGNC:28817 xref: UniGene:Hs.370927 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005845 ! LRC59_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004989 name: LRSAM1_human def: "E3 ubiquitin-protein ligase LRSAM1 gene" [UniProtKB:Q6UWE0] synonym: "TAL" EXACT [UniProtKB:Q6UWE0] synonym: "UNQ6496/PRO21356" EXACT [UniProtKB:Q6UWE0] xref: EMBL:AK056203 xref: EMBL:AK056305 xref: EMBL:AK091589 xref: EMBL:AL445222 xref: EMBL:AY358830 xref: EMBL:BC009239 xref: HGNC:HGNC:25135 xref: UniGene:Hs.495188 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006335 ! LRSM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004990 name: AOF2_human def: "Lysine-specific histone demethylase 1 gene" [UniProtKB:O60341] synonym: "KIAA0601" EXACT [UniProtKB:O60341] synonym: "LSD1" EXACT [UniProtKB:O60341] xref: EMBL:AB011173 xref: EMBL:AL031428 xref: EMBL:AL833812 xref: EMBL:BC016639 xref: EMBL:BC025362 xref: EMBL:BC040194 xref: EMBL:BC048134 xref: HGNC:HGNC:29079 xref: UniGene:Hs.591518 xref: UniGene:Hs.656420 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005589 ! LSD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004991 name: LSM1_human def: "U6 snRNA-associated Sm-like protein LSm1 gene" [UniProtKB:O15116] synonym: "CASM" EXACT [UniProtKB:O15116] xref: EMBL:AF000177 xref: EMBL:AJ238094 xref: EMBL:BC001767 xref: HGNC:HGNC:20472 xref: UniGene:Hs.425311 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006005 ! LSM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004992 name: LSM3_human def: "U6 snRNA-associated Sm-like protein LSm3 gene" [UniProtKB:P62310] synonym: "MDS017" EXACT [UniProtKB:P62310] xref: EMBL:AF182289 xref: EMBL:AF182418 xref: EMBL:AJ238095 xref: EMBL:BC007055 xref: HGNC:HGNC:17874 xref: UniGene:Hs.111632 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005566 ! LSM3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004994 name: LSM7_human def: "U6 snRNA-associated Sm-like protein LSm7 gene" [UniProtKB:Q9UK45] xref: EMBL:AC005258 xref: EMBL:AF182293 xref: EMBL:BC018621 xref: HGNC:HGNC:20470 xref: UniGene:Hs.512610 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005494 ! LSM7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004995 name: LSM8_human def: "U6 snRNA-associated Sm-like protein LSm8 gene" [UniProtKB:O95777] xref: EMBL:AC006389 xref: EMBL:AF182294 xref: EMBL:BC002742 xref: EMBL:BC022440 xref: HGNC:HGNC:20471 xref: UniGene:Hs.657737 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005349 ! LSM8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004997 name: ALOX15B_human def: "Arachidonate 15-lipoxygenase type II gene" [UniProtKB:O15296] xref: EMBL:AF149095 xref: EMBL:AF468051 xref: EMBL:AF468052 xref: EMBL:AF468053 xref: EMBL:AF468054 xref: EMBL:AJ305028 xref: EMBL:AJ305029 xref: EMBL:AJ305030 xref: EMBL:AJ305031 xref: EMBL:BC035217 xref: EMBL:BC063647 xref: EMBL:U78294 xref: HGNC:HGNC:434 xref: UniGene:Hs.111256 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001371 ! LX15B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0004998 name: LYN_human def: "Tyrosine-protein kinase Lyn gene" [UniProtKB:P07948] xref: EMBL:BC075001 xref: EMBL:BC075002 xref: EMBL:BC126456 xref: EMBL:BC126458 xref: EMBL:M16038 xref: EMBL:M79321 xref: HGNC:HGNC:6735 xref: UniGene:Hs.699154 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005457 ! LYN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005000 name: LZTS1_human def: "Leucine zipper putative tumor suppressor 1 gene" [UniProtKB:Q9Y250] synonym: "FEZ1" EXACT [UniProtKB:Q9Y250] xref: EMBL:AF123652 xref: EMBL:AF123653 xref: EMBL:AF123654 xref: EMBL:AF123655 xref: EMBL:AF123656 xref: EMBL:AF123657 xref: EMBL:AF123658 xref: EMBL:AF123659 xref: EMBL:BC075006 xref: EMBL:BC075007 xref: HGNC:HGNC:13861 xref: UniGene:Hs.521432 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002248 ! LZTS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005001 name: LZTS2_human def: "Leucine zipper putative tumor suppressor 2 gene" [UniProtKB:Q9BRK4] synonym: "KIAA1813" EXACT [UniProtKB:Q9BRK4] synonym: "LAPSER1" EXACT [UniProtKB:Q9BRK4] xref: EMBL:AB058716 xref: EMBL:AL834338 xref: EMBL:AY029201 xref: EMBL:BC006212 xref: EMBL:BC058938 xref: HGNC:HGNC:29381 xref: UniGene:Hs.523221 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002094 ! LZTS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005002 name: MID1IP1_human def: "Mid1-interacting protein 1 gene" [UniProtKB:Q9NPA3] synonym: "MIG12" EXACT [UniProtKB:Q9NPA3] xref: EMBL:AJ272057 xref: EMBL:AK001248 xref: EMBL:BC008908 xref: EMBL:BC019332 xref: EMBL:BK001260 xref: EMBL:CR457220 xref: HGNC:HGNC:20715 xref: UniGene:Hs.522605 xref: UniGene:Hs.705525 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005281 ! M1IP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005003 name: SLC25A11_human def: "Mitochondrial 2-oxoglutarate/malate carrier protein gene" [UniProtKB:Q02978] synonym: "SLC20A4" EXACT [UniProtKB:Q02978] xref: EMBL:AF070548 xref: EMBL:BC006508 xref: EMBL:BC006519 xref: EMBL:BC016294 xref: EMBL:BC017170 xref: EMBL:X66114 xref: HGNC:HGNC:10981 xref: UniGene:Hs.184877 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006316 ! M2OM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005004 name: MAP3K11_human def: "Mitogen-activated protein kinase kinase kinase 11 gene" [UniProtKB:Q16584] synonym: "MLK3" EXACT [UniProtKB:Q16584] synonym: "PTK1" EXACT [UniProtKB:Q16584] synonym: "SPRK" EXACT [UniProtKB:Q16584] xref: EMBL:AB209655 xref: EMBL:AK222781 xref: EMBL:BC011263 xref: EMBL:BC064543 xref: EMBL:L32976 xref: EMBL:U07747 xref: HGNC:HGNC:6850 xref: UniGene:Hs.502872 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001820 ! M3K11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005005 name: MAP3K14_human def: "Mitogen-activated protein kinase kinase kinase 14 gene" [UniProtKB:Q99558] synonym: "NIK" EXACT [UniProtKB:Q99558] xref: EMBL:BC035576 xref: EMBL:DQ314874 xref: EMBL:Y10256 xref: HGNC:HGNC:6853 xref: UniGene:Hs.404183 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005528 ! M3K14_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005006 name: MAP3K1_human def: "Mitogen-activated protein kinase kinase kinase 1 gene" [UniProtKB:Q13233] synonym: "MAPKKK1" EXACT [UniProtKB:Q13233] synonym: "MEKK" EXACT [UniProtKB:Q13233] synonym: "MEKK1" EXACT [UniProtKB:Q13233] xref: EMBL:AC008937 xref: EMBL:AF042838 xref: EMBL:U29671 xref: HGNC:HGNC:6848 xref: UniGene:Hs.657756 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005525 ! M3K1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005007 name: MAP3K3_human def: "Mitogen-activated protein kinase kinase kinase 3 gene" [UniProtKB:Q99759] synonym: "MAPKKK3" EXACT [UniProtKB:Q99759] synonym: "MEKK3" EXACT [UniProtKB:Q99759] xref: EMBL:BC090859 xref: EMBL:BC093672 xref: EMBL:BC093674 xref: EMBL:CH471109 xref: EMBL:U78876 xref: HGNC:HGNC:6855 xref: UniGene:Hs.29282 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005526 ! M3K3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005008 name: MAP3K4_human def: "Mitogen-activated protein kinase kinase kinase 4 gene" [UniProtKB:Q9Y6R4] synonym: "KIAA0213" EXACT [UniProtKB:Q9Y6R4] synonym: "MAPKKK4" EXACT [UniProtKB:Q9Y6R4] synonym: "MEKK4" EXACT [UniProtKB:Q9Y6R4] synonym: "MTK1" EXACT [UniProtKB:Q9Y6R4] xref: EMBL:AF002715 xref: EMBL:D86968 xref: HGNC:HGNC:6856 xref: UniGene:Hs.390428 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005915 ! M3K4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005010 name: MAP3K8_human def: "Mitogen-activated protein kinase kinase kinase 8 gene" [UniProtKB:P41279] synonym: "COT" EXACT [UniProtKB:P41279] synonym: "ESTF" EXACT [UniProtKB:P41279] xref: EMBL:AF133211 xref: EMBL:AL161651 xref: EMBL:AY309013 xref: EMBL:BC104833 xref: EMBL:BC113566 xref: EMBL:D14497 xref: EMBL:Z14138 xref: HGNC:HGNC:6860 xref: UniGene:Hs.432453 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005520 ! M3K8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005011 name: MAP4K2_human def: "Mitogen-activated protein kinase kinase kinase kinase 2 gene" [UniProtKB:Q12851] synonym: "GCK" EXACT [UniProtKB:Q12851] synonym: "RAB8IP" EXACT [UniProtKB:Q12851] xref: EMBL:U07349 xref: HGNC:HGNC:6864 xref: UniGene:Hs.534341 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005706 ! M4K2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005012 name: MACF1_human def: "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 gene" [UniProtKB:Q9UPN3] synonym: "ABP620" EXACT [UniProtKB:Q9UPN3] synonym: "ACF7" EXACT [UniProtKB:Q9UPN3] synonym: "KIAA0465" EXACT [UniProtKB:Q9UPN3] synonym: "KIAA1251" EXACT [UniProtKB:Q9UPN3] xref: EMBL:AB007934 xref: EMBL:AB029290 xref: EMBL:AB033077 xref: EMBL:AF141968 xref: EMBL:AF317696 xref: EMBL:AF325330 xref: EMBL:AF325331 xref: EMBL:AF325332 xref: EMBL:AF325333 xref: EMBL:AF325334 xref: EMBL:AF325335 xref: EMBL:AF325336 xref: EMBL:AF325339 xref: EMBL:AF325340 xref: EMBL:AF325341 xref: EMBL:AL137853 xref: EMBL:AL355477 xref: EMBL:AL365277 xref: EMBL:AL442071 xref: HGNC:HGNC:13664 xref: UniGene:Hs.580782 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002053 ! MACF4_HUMAN relationship: codes_for CCO:B0002237 ! MACF1_HUMAN relationship: codes_for CCO:B0041233 ! B1ALC7_HUMAN relationship: codes_for CCO:B0041235 ! B1ANQ7_HUMAN relationship: codes_for CCO:B0041236 ! B1ANR2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005013 name: MADD_human def: "MAP kinase-activating death domain protein gene" [UniProtKB:Q8WXG6] synonym: "DENN" EXACT [UniProtKB:Q8WXG6] synonym: "IG20" EXACT [UniProtKB:Q8WXG6] synonym: "KIAA0358" EXACT [UniProtKB:Q8WXG6] xref: EMBL:AB002356 xref: EMBL:AF440100 xref: EMBL:AF440101 xref: EMBL:AF440102 xref: EMBL:AF440103 xref: EMBL:AF440434 xref: EMBL:BC040484 xref: EMBL:U44953 xref: EMBL:U77352 xref: HGNC:HGNC:6766 xref: UniGene:Hs.82548 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002010 ! MADD_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005014 name: MAEA_human def: "Macrophage erythroblast attacher gene" [UniProtKB:Q7L5Y9] synonym: "EMP" EXACT [UniProtKB:Q7L5Y9] synonym: "HLC10" EXACT [UniProtKB:Q7L5Y9] synonym: "PIG5" EXACT [UniProtKB:Q7L5Y9] xref: EMBL:AF084928 xref: EMBL:AK001088 xref: EMBL:AK022515 xref: EMBL:AK022586 xref: EMBL:AK128302 xref: EMBL:AY189687 xref: EMBL:AY236486 xref: EMBL:BC001225 xref: EMBL:BC006470 xref: EMBL:BT006957 xref: HGNC:HGNC:13731 xref: UniGene:Hs.139896 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001930 ! MAEA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005015 name: MAF1_human def: "Repressor of RNA polymerase III transcription MAF1 homolog gene" [UniProtKB:Q9H063] xref: EMBL:AL136937 xref: EMBL:BC014082 xref: EMBL:BC018714 xref: EMBL:BC031273 xref: EMBL:CR533463 xref: HGNC:HGNC:24966 xref: UniGene:Hs.19673 xref: UniGene:Hs.529755 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005301 ! MAF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005016 name: MAGEA11_human def: "Melanoma-associated antigen 11 gene" [UniProtKB:P43364] synonym: "MAGE11" EXACT [UniProtKB:P43364] xref: EMBL:AK127849 xref: EMBL:AY747607 xref: EMBL:BC004479 xref: EMBL:U10686 xref: HGNC:HGNC:6798 xref: UniGene:Hs.670252 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005212 ! MAGAB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005018 name: MAGEB18_human def: "Melanoma-associated antigen B18 gene" [UniProtKB:Q96M61] xref: EMBL:AK057361 xref: EMBL:BC029525 xref: HGNC:HGNC:28515 xref: UniGene:Hs.350683 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005185 ! MAGBI_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005020 name: MAGED1_human def: "Melanoma-associated antigen D1 gene" [UniProtKB:Q9Y5V3] synonym: "NRAGE" EXACT [UniProtKB:Q9Y5V3] synonym: "PP2250" EXACT [UniProtKB:Q9Y5V3] synonym: "PRO2292" EXACT [UniProtKB:Q9Y5V3] xref: EMBL:AF124440 xref: EMBL:AF132205 xref: EMBL:AF217963 xref: EMBL:AF258554 xref: EMBL:AF300328 xref: EMBL:AL133628 xref: EMBL:AL929410 xref: EMBL:BC014070 xref: EMBL:BC032473 xref: HGNC:HGNC:6813 xref: UniGene:Hs.5258 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006204 ! MAGD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005021 name: MAGEH1_human def: "Melanoma-associated antigen H1 gene" [UniProtKB:Q9H213] synonym: "APR1" EXACT [UniProtKB:Q9H213] xref: EMBL:AF143235 xref: EMBL:AF320912 xref: EMBL:AL590410 xref: EMBL:BC011954 xref: HGNC:HGNC:24092 xref: UniGene:Hs.279819 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005406 ! MAGH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005022 name: MAP9_human def: "Microtubule-associated protein 9 gene" [UniProtKB:Q49MG5] synonym: "ASAP" EXACT [UniProtKB:Q49MG5] xref: EMBL:AC097467 xref: EMBL:AK024730 xref: EMBL:AK024812 xref: EMBL:AY690636 xref: EMBL:CR749274 xref: HGNC:HGNC:26118 xref: UniGene:Hs.61271 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001834 ! MAP9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005023 name: MAPKAPK5_human def: "MAP kinase-activated protein kinase 5 gene" [UniProtKB:Q8IW41] synonym: "PRAK" EXACT [UniProtKB:Q8IW41] xref: EMBL:AF032437 xref: EMBL:AL110301 xref: EMBL:BC000833 xref: EMBL:BC041049 xref: EMBL:BC047284 xref: HGNC:HGNC:6889 xref: UniGene:Hs.413901 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005891 ! MAPK5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005024 name: MAPRE1_human def: "Microtubule-associated protein RP/EB family member 1 gene" [UniProtKB:Q15691] xref: EMBL:AL035071 xref: EMBL:BC106068 xref: EMBL:BC109281 xref: EMBL:U24166 xref: HGNC:HGNC:6890 xref: UniGene:Hs.472437 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001812 ! MARE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005025 name: MAPRE2_human def: "Microtubule-associated protein RP/EB family member 2 gene" [UniProtKB:Q15555] synonym: "RP1" EXACT [UniProtKB:Q15555] xref: EMBL:AB016823 xref: EMBL:BC007318 xref: EMBL:BT020086 xref: EMBL:CR536545 xref: EMBL:X94232 xref: HGNC:HGNC:6891 xref: UniGene:Hs.532824 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001811 ! MARE2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005026 name: MAPRE3_human def: "Microtubule-associated protein RP/EB family member 3 gene" [UniProtKB:Q9UPY8] xref: EMBL:AB025186 xref: EMBL:AF288787 xref: EMBL:BC011557 xref: EMBL:CR536523 xref: EMBL:Y11174 xref: HGNC:HGNC:6892 xref: UniGene:Hs.515860 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002238 ! MARE3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005028 name: MARK4_human def: "MAP/microtubule affinity-regulating kinase 4 gene" [UniProtKB:Q96L34] synonym: "KIAA1860" EXACT [UniProtKB:Q96L34] synonym: "MARKL1" EXACT [UniProtKB:Q96L34] xref: EMBL:AB049127 xref: EMBL:AB058763 xref: EMBL:AB088047 xref: EMBL:AK027619 xref: EMBL:AK075272 xref: EMBL:AY057448 xref: EMBL:AY120867 xref: HGNC:HGNC:13538 xref: UniGene:Hs.34314 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005344 ! MARK4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005029 name: MAST3_human def: "Microtubule-associated serine/threonine-protein kinase 3 gene" [UniProtKB:O60307] synonym: "KIAA0561" EXACT [UniProtKB:O60307] xref: EMBL:AB011133 xref: EMBL:AC005793 xref: EMBL:AC007192 xref: EMBL:AC093054 xref: HGNC:HGNC:19036 xref: UniGene:Hs.466184 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005499 ! MAST3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005030 name: MNAT1_human def: "CDK-activating kinase assembly factor MAT1 gene" [UniProtKB:P51948] synonym: "CAP35" EXACT [UniProtKB:P51948] synonym: "MAT1" EXACT [UniProtKB:P51948] synonym: "RNF66" EXACT [UniProtKB:P51948] xref: EMBL:AY165512 xref: EMBL:BC000820 xref: EMBL:U61835 xref: EMBL:X87843 xref: EMBL:X92669 xref: HGNC:HGNC:7181 xref: UniGene:Hs.509523 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001653 ! MAT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005032 name: MATR3_human def: "Matrin-3 gene" [UniProtKB:P43243] synonym: "KIAA0723" EXACT [UniProtKB:P43243] xref: EMBL:AB018266 xref: EMBL:AF117236 xref: EMBL:BC015031 xref: EMBL:M63483 xref: HGNC:HGNC:6912 xref: UniGene:Hs.268939 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005968 ! MATR3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005033 name: MAX_human def: "Protein max gene" [UniProtKB:P61244] xref: EMBL:BC003525 xref: EMBL:BC004516 xref: EMBL:BC027924 xref: EMBL:M64240 xref: EMBL:X60287 xref: EMBL:X66867 xref: HGNC:HGNC:6913 xref: UniGene:Hs.285354 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005336 ! MAX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005034 name: MBD1_human def: "Methyl-CpG-binding domain protein 1 gene" [UniProtKB:Q9UIS9] synonym: "CXXC3" EXACT [UniProtKB:Q9UIS9] synonym: "PCM1" EXACT [UniProtKB:Q9UIS9] xref: EMBL:AF072241 xref: EMBL:AF078830 xref: EMBL:AF078831 xref: EMBL:AF078832 xref: EMBL:AF078833 xref: EMBL:AF120980 xref: EMBL:AF120981 xref: EMBL:AJ564845 xref: EMBL:BC033242 xref: EMBL:EF488685 xref: EMBL:Y10746 xref: HGNC:HGNC:6916 xref: UniGene:Hs.405610 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005510 ! MBD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005035 name: MBIP_human def: "MAP3K12-binding inhibitory protein 1 gene" [UniProtKB:Q9NS73] synonym: "BM-015" EXACT [UniProtKB:Q9NS73] xref: EMBL:AB038523 xref: EMBL:AF208857 xref: EMBL:BC005197 xref: EMBL:BC016821 xref: EMBL:BX248287 xref: HGNC:HGNC:20427 xref: UniGene:Hs.368647 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005271 ! MBIP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005036 name: MCM10_human def: "Protein MCM10 homolog gene" [UniProtKB:Q7L590] synonym: "PRO2249" EXACT [UniProtKB:Q7L590] xref: EMBL:AB042719 xref: EMBL:AF119869 xref: EMBL:AK055695 xref: EMBL:AL136840 xref: EMBL:AL138764 xref: EMBL:AL355355 xref: EMBL:BC004876 xref: EMBL:BC101727 xref: HGNC:HGNC:18043 xref: UniGene:Hs.198363 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001929 ! MCM10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005037 name: MCM2_human def: "DNA replication licensing factor MCM2 gene" [UniProtKB:P49736] synonym: "BM28" EXACT [UniProtKB:P49736] synonym: "CCNL1" EXACT [UniProtKB:P49736] synonym: "CDCL1" EXACT [UniProtKB:P49736] synonym: "KIAA0030" EXACT [UniProtKB:P49736] xref: EMBL:AY675259 xref: EMBL:BC006165 xref: EMBL:BC007670 xref: EMBL:BC007938 xref: EMBL:BC014272 xref: EMBL:BC017258 xref: EMBL:BC017490 xref: EMBL:BC030131 xref: EMBL:BT009734 xref: EMBL:D21063 xref: EMBL:D83987 xref: EMBL:X67334 xref: HGNC:HGNC:6944 xref: UniGene:Hs.477481 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001631 ! MCM2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005038 name: MCM3_human def: "DNA replication licensing factor MCM3 gene" [UniProtKB:P25205] xref: EMBL:AL034343 xref: EMBL:AY621074 xref: EMBL:BC001626 xref: EMBL:BC003509 xref: EMBL:D38073 xref: EMBL:X62153 xref: HGNC:HGNC:6945 xref: UniGene:Hs.179565 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001558 ! MCM3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005039 name: MCM4_human def: "DNA replication licensing factor MCM4 gene" [UniProtKB:P33991] synonym: "CDC21" EXACT [UniProtKB:P33991] xref: EMBL:AY588245 xref: EMBL:BC031061 xref: EMBL:U63630 xref: EMBL:U90415 xref: EMBL:X74794 xref: HGNC:HGNC:6947 xref: UniGene:Hs.460184 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005391 ! MCM4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005040 name: MCM5_human def: "DNA replication licensing factor MCM5 gene" [UniProtKB:P33992] synonym: "CDC46" EXACT [UniProtKB:P33992] xref: EMBL:AY212028 xref: EMBL:BC000142 xref: EMBL:BC003656 xref: EMBL:CR456517 xref: EMBL:D83986 xref: EMBL:X74795 xref: EMBL:Z82244 xref: HGNC:HGNC:6948 xref: UniGene:Hs.517582 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001588 ! MCM5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005041 name: MCM6_human def: "DNA replication licensing factor MCM6 gene" [UniProtKB:Q14566] xref: EMBL:AY220757 xref: EMBL:BC032374 xref: EMBL:D84557 xref: EMBL:U46838 xref: EMBL:U67281 xref: EMBL:U67282 xref: EMBL:U67283 xref: EMBL:U67284 xref: HGNC:HGNC:6949 xref: UniGene:Hs.444118 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001785 ! MCM6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005042 name: MCM7_human def: "DNA replication licensing factor MCM7 gene" [UniProtKB:P33993] synonym: "CDC47" EXACT [UniProtKB:P33993] synonym: "MCM2" EXACT [UniProtKB:P33993] xref: EMBL:BC009398 xref: EMBL:BC013375 xref: EMBL:D28480 xref: EMBL:D55716 xref: EMBL:X74796 xref: HGNC:HGNC:6950 xref: UniGene:Hs.438720 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001589 ! MCM7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005043 name: MCM8_human def: "DNA replication licensing factor MCM8 gene" [UniProtKB:Q9UJA3] synonym: "C20orf154" EXACT [UniProtKB:Q9UJA3] xref: EMBL:AJ439063 xref: EMBL:AK027644 xref: EMBL:AL035461 xref: EMBL:AY158211 xref: EMBL:BC008830 xref: EMBL:BC080656 xref: EMBL:BC101054 xref: EMBL:BC101056 xref: EMBL:BC101057 xref: HGNC:HGNC:16147 xref: UniGene:Hs.631506 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002210 ! MCM8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005044 name: MCRS1_human def: "Microspherule protein 1 gene" [UniProtKB:Q96EZ8] synonym: "MSP58" EXACT [UniProtKB:Q96EZ8] xref: EMBL:AF015308 xref: EMBL:AF068007 xref: EMBL:AY336730 xref: EMBL:BC011794 xref: HGNC:HGNC:6960 xref: UniGene:Hs.25313 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002036 ! MCRS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005046 name: MAD1L1_human def: "Mitotic spindle assembly checkpoint protein MAD1 gene" [UniProtKB:Q9Y6D9] synonym: "MAD1" EXACT [UniProtKB:Q9Y6D9] synonym: "TXBP181" EXACT [UniProtKB:Q9Y6D9] xref: EMBL:AC005282 xref: EMBL:AC006433 xref: EMBL:AC069288 xref: EMBL:AC104129 xref: EMBL:AC110781 xref: EMBL:AF083811 xref: EMBL:AF123318 xref: EMBL:BC009964 xref: EMBL:U33822 xref: HGNC:HGNC:6762 xref: UniGene:Hs.654838 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002264 ! MD1L1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005047 name: MAD2L1BP_human def: "MAD2L1-binding protein gene" [UniProtKB:Q15013] synonym: "CMT2" EXACT [UniProtKB:Q15013] synonym: "KIAA0110" EXACT [UniProtKB:Q15013] xref: EMBL:AL136131 xref: EMBL:AL353602 xref: EMBL:BC002904 xref: EMBL:D14811 xref: HGNC:HGNC:21059 xref: UniGene:Hs.122346 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001341 ! A6NMP7_HUMAN relationship: codes_for CCO:B0001799 ! MD2BP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005048 name: MAD2L1_human def: "Mitotic spindle assembly checkpoint protein MAD2A gene" [UniProtKB:Q13257] synonym: "MAD2" EXACT [UniProtKB:Q13257] xref: EMBL:AB056160 xref: EMBL:AF394735 xref: EMBL:AJ000186 xref: EMBL:BC000356 xref: EMBL:BC005945 xref: EMBL:CH471056 xref: EMBL:U31278 xref: EMBL:U65410 xref: HGNC:HGNC:6763 xref: UniGene:Hs.591697 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001748 ! MD2L1_HUMAN relationship: codes_for CCO:B0001958 ! Q8IZX3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005049 name: MAD2L2_human def: "Mitotic spindle assembly checkpoint protein MAD2B gene" [UniProtKB:Q9UI95] synonym: "MAD2B" EXACT [UniProtKB:Q9UI95] synonym: "REV7" EXACT [UniProtKB:Q9UI95] xref: EMBL:AF072933 xref: EMBL:AF080398 xref: EMBL:AF139365 xref: EMBL:AF157482 xref: EMBL:AL031731 xref: EMBL:BC015244 xref: EMBL:DQ017900 xref: HGNC:HGNC:6764 xref: UniGene:Hs.19400 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002204 ! MD2L2_HUMAN relationship: codes_for CCO:B0041228 ! B1AK43_HUMAN relationship: codes_for CCO:B0041229 ! B1AK44_HUMAN relationship: codes_for CCO:B0041230 ! B1AK45_HUMAN relationship: codes_for CCO:B0041231 ! B1AK46_HUMAN relationship: codes_for CCO:B0041232 ! B1AK47_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005050 name: MDC1_human def: "Mediator of DNA damage checkpoint protein 1 gene" [UniProtKB:Q14676] synonym: "KIAA0170" EXACT [UniProtKB:Q14676] synonym: "NFBD1" EXACT [UniProtKB:Q14676] xref: EMBL:AB088099 xref: EMBL:AL662797 xref: EMBL:AL662848 xref: EMBL:AL845353 xref: EMBL:BA000025 xref: EMBL:CR749828 xref: EMBL:D79992 xref: HGNC:HGNC:21163 xref: UniGene:Hs.519993 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001788 ! MDC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005051 name: MDFI_human def: "MyoD family inhibitor gene" [UniProtKB:Q99750] xref: EMBL:AL035588 xref: EMBL:BC007836 xref: EMBL:U78313 xref: HGNC:HGNC:6967 xref: UniGene:Hs.520119 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005232 ! MDFI_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005052 name: MDM2_human def: "E3 ubiquitin-protein ligase Mdm2 gene" [UniProtKB:Q00987] xref: EMBL:AF092844 xref: EMBL:AF092845 xref: EMBL:AF201370 xref: EMBL:AF527840 xref: EMBL:AJ251943 xref: EMBL:BT007258 xref: EMBL:M92424 xref: EMBL:U28935 xref: EMBL:U33199 xref: EMBL:U33200 xref: EMBL:U33201 xref: EMBL:U33202 xref: EMBL:U33203 xref: EMBL:U39736 xref: EMBL:Z12020 xref: HGNC:HGNC:6973 xref: UniGene:Hs.567303 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001712 ! MDM2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005053 name: MDM4_human def: "Mdm4 protein gene" [UniProtKB:O15151] synonym: "MDMX" EXACT [UniProtKB:O15151] xref: EMBL:AF007111 xref: EMBL:AK223228 xref: EMBL:AL512306 xref: EMBL:AY207458 xref: EMBL:BC067299 xref: HGNC:HGNC:6974 xref: UniGene:Hs.702385 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001366 ! MDM4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005054 name: MED10_human def: "Mediator of RNA polymerase II transcription subunit 10 gene" [UniProtKB:Q9BTT4] synonym: "L6" EXACT [UniProtKB:Q9BTT4] synonym: "TRG17" EXACT [UniProtKB:Q9BTT4] synonym: "TRG20" EXACT [UniProtKB:Q9BTT4] xref: EMBL:AY277599 xref: EMBL:AY453397 xref: EMBL:AY598325 xref: EMBL:BC003353 xref: EMBL:CH471102 xref: HGNC:HGNC:28760 xref: UniGene:Hs.13885 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005573 ! MED10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005067 name: MED23_human def: "Mediator of RNA polymerase II transcription subunit 23 gene" [UniProtKB:Q9ULK4] synonym: "ARC130" EXACT [UniProtKB:Q9ULK4] synonym: "CRSP3" EXACT [UniProtKB:Q9ULK4] synonym: "DRIP130" EXACT [UniProtKB:Q9ULK4] synonym: "KIAA1216" EXACT [UniProtKB:Q9ULK4] synonym: "SUR2" EXACT [UniProtKB:Q9ULK4] xref: EMBL:AB033042 xref: EMBL:AF104255 xref: EMBL:AF105332 xref: EMBL:AF135022 xref: EMBL:AL121575 xref: EMBL:AL136776 xref: EMBL:BC060759 xref: EMBL:CH471051 xref: HGNC:HGNC:2372 xref: UniGene:Hs.29679 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005793 ! MED23_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005072 name: MED29_human def: "Mediator of RNA polymerase II transcription subunit 29 gene" [UniProtKB:Q9NX70] synonym: "IXL" EXACT [UniProtKB:Q9NX70] xref: EMBL:AK000411 xref: EMBL:AL137304 xref: EMBL:AY729650 xref: EMBL:BC019015 xref: HGNC:HGNC:23074 xref: UniGene:Hs.611541 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005574 ! MED29_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005074 name: MED31_human def: "Mediator of RNA polymerase II transcription subunit 31 gene" [UniProtKB:Q9Y3C7] synonym: "CGI-125" EXACT [UniProtKB:Q9Y3C7] synonym: "SOH1" EXACT [UniProtKB:Q9Y3C7] xref: EMBL:AF151883 xref: EMBL:BC012539 xref: HGNC:HGNC:24260 xref: UniGene:Hs.567493 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005784 ! MED31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005079 name: MED9_human def: "Mediator of RNA polymerase II transcription subunit 9 gene" [UniProtKB:Q9NWA0] synonym: "MED25" EXACT [UniProtKB:Q9NWA0] xref: EMBL:AK001055 xref: EMBL:BC104988 xref: EMBL:BC112029 xref: EMBL:CH471196 xref: HGNC:HGNC:25487 xref: UniGene:Hs.244595 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005475 ! MED9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005081 name: MEGF6_human def: "Multiple epidermal growth factor-like domains 6 precursor gene" [UniProtKB:O75095] synonym: "EGFL3" EXACT [UniProtKB:O75095] synonym: "KIAA0815" EXACT [UniProtKB:O75095] xref: EMBL:AB011539 xref: EMBL:AL512413 xref: EMBL:AL513320 xref: HGNC:HGNC:3232 xref: UniGene:Hs.593645 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005956 ! MEGF6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005082 name: MEGF8_human def: "Multiple epidermal growth factor-like domains 8 gene" [UniProtKB:Q7Z7M0] synonym: "C19orf49" EXACT [UniProtKB:Q7Z7M0] synonym: "EGFL4" EXACT [UniProtKB:Q7Z7M0] synonym: "KIAA0817" EXACT [UniProtKB:Q7Z7M0] xref: EMBL:AB011541 xref: EMBL:AY280362 xref: HGNC:HGNC:3233 xref: UniGene:Hs.132483 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005957 ! MEGF8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005083 name: MEOX2_human def: "Homeobox protein MOX-2 gene" [UniProtKB:P50222] synonym: "GAX" EXACT [UniProtKB:P50222] synonym: "MOX2" EXACT [UniProtKB:P50222] xref: EMBL:AC004452 xref: EMBL:AC005550 xref: EMBL:BC017021 xref: EMBL:L36328 xref: EMBL:X82629 xref: HGNC:HGNC:7014 xref: UniGene:Hs.170355 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005623 ! MEOX2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005084 name: THOP1_human def: "Thimet oligopeptidase gene" [UniProtKB:P52888] xref: EMBL:AC006538 xref: EMBL:BC000135 xref: EMBL:BC002391 xref: EMBL:U29366 xref: EMBL:Z50115 xref: HGNC:HGNC:11793 xref: UniGene:Hs.78769 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0035951 ! THOP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005085 name: NF2_human def: "Merlin gene" [UniProtKB:P35240] synonym: "SCH" EXACT [UniProtKB:P35240] xref: EMBL:AF122827 xref: EMBL:AF122828 xref: EMBL:AF123570 xref: EMBL:AF369657 xref: EMBL:AF369658 xref: EMBL:AF369661 xref: EMBL:AF369662 xref: EMBL:AF369663 xref: EMBL:AF369664 xref: EMBL:AF369665 xref: EMBL:AF369700 xref: EMBL:AF369701 xref: EMBL:BC003112 xref: EMBL:BC020257 xref: EMBL:CR456530 xref: EMBL:L11353 xref: EMBL:X72655 xref: EMBL:X72656 xref: EMBL:X72657 xref: EMBL:X72658 xref: EMBL:X72659 xref: EMBL:X72660 xref: EMBL:X72661 xref: EMBL:X72662 xref: EMBL:X72663 xref: EMBL:X72664 xref: EMBL:X72665 xref: EMBL:X72666 xref: EMBL:X72667 xref: EMBL:X72668 xref: EMBL:X72669 xref: EMBL:X72670 xref: EMBL:Y18000 xref: EMBL:Z22664 xref: HGNC:HGNC:7773 xref: UniGene:Hs.187898 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001592 ! MERL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005086 name: MET_human def: "Hepatocyte growth factor receptor precursor gene" [UniProtKB:P08581] xref: EMBL:AC002080 xref: EMBL:AC002543 xref: EMBL:AC004416 xref: EMBL:J02958 xref: EMBL:M35074 xref: EMBL:U08818 xref: EMBL:X54559 xref: HGNC:HGNC:7029 xref: UniGene:Hs.132966 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005438 ! MET_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005087 name: SPEN_human def: "Msx2-interacting protein gene" [UniProtKB:Q96T58] synonym: "KIAA0929" EXACT [UniProtKB:Q96T58] synonym: "MINT" EXACT [UniProtKB:Q96T58] synonym: "SHARP" EXACT [UniProtKB:Q96T58] xref: EMBL:AB023146 xref: EMBL:AF356524 xref: EMBL:AK000882 xref: EMBL:AK022949 xref: EMBL:AL034555 xref: EMBL:AL096858 xref: EMBL:AL450998 xref: HGNC:HGNC:17575 xref: UniGene:Hs.558463 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006042 ! MINT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005088 name: MIS12_human def: "Protein MIS12 homolog gene" [UniProtKB:Q9H081] xref: EMBL:AK056072 xref: EMBL:AL136906 xref: EMBL:BC000229 xref: EMBL:CR533460 xref: HGNC:HGNC:24967 xref: UniGene:Hs.267194 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002122 ! MIS12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005089 name: MAPK1_human def: "Mitogen-activated protein kinase 1 gene" [UniProtKB:P28482] synonym: "ERK2" EXACT [UniProtKB:P28482] synonym: "PRKM1" EXACT [UniProtKB:P28482] synonym: "PRKM2" EXACT [UniProtKB:P28482] xref: EMBL:BC017832 xref: EMBL:M84489 xref: EMBL:Z11694 xref: EMBL:Z11695 xref: HGNC:HGNC:6871 xref: UniGene:Hs.431850 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001565 ! MK01_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005090 name: MAPK3_human def: "Mitogen-activated protein kinase 3 gene" [UniProtKB:P27361] synonym: "ERK1" EXACT [UniProtKB:P27361] synonym: "PRKM3" EXACT [UniProtKB:P27361] xref: EMBL:BC013992 xref: EMBL:M84490 xref: EMBL:X60188 xref: EMBL:Z11696 xref: HGNC:HGNC:6877 xref: UniGene:Hs.861 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001560 ! MK03_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005091 name: MAPK4_human def: "Mitogen-activated protein kinase 4 gene" [UniProtKB:P31152] synonym: "ERK4" EXACT [UniProtKB:P31152] synonym: "PRKM4" EXACT [UniProtKB:P31152] xref: EMBL:X59727 xref: HGNC:HGNC:6878 xref: UniGene:Hs.433728 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001582 ! MK04_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005092 name: MAPK6_human def: "Mitogen-activated protein kinase 6 gene" [UniProtKB:Q16659] synonym: "ERK3" EXACT [UniProtKB:Q16659] synonym: "PRKM6" EXACT [UniProtKB:Q16659] xref: EMBL:AF420474 xref: EMBL:BC035492 xref: EMBL:CR749401 xref: EMBL:L77964 xref: EMBL:X80692 xref: HGNC:HGNC:6879 xref: UniGene:Hs.411847 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001822 ! MK06_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005094 name: MAPK11_human def: "Mitogen-activated protein kinase 11 gene" [UniProtKB:Q15759] synonym: "PRKM11" EXACT [UniProtKB:Q15759] synonym: "SAPK2" EXACT [UniProtKB:Q15759] xref: EMBL:AF001008 xref: EMBL:AF001174 xref: EMBL:AF031135 xref: EMBL:AL022328 xref: EMBL:BC027933 xref: EMBL:CR456514 xref: EMBL:DQ279722 xref: EMBL:U53442 xref: EMBL:U92268 xref: EMBL:Y14440 xref: HGNC:HGNC:6873 xref: UniGene:Hs.57732 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005892 ! MK11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005095 name: MAPK12_human def: "Mitogen-activated protein kinase 12 gene" [UniProtKB:P53778] synonym: "ERK6" EXACT [UniProtKB:P53778] synonym: "SAPK3" EXACT [UniProtKB:P53778] xref: EMBL:AL022328 xref: EMBL:BC015741 xref: EMBL:U66243 xref: EMBL:X79483 xref: EMBL:Y10487 xref: HGNC:HGNC:6874 xref: UniGene:Hs.432642 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001665 ! MK12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005096 name: MAPK13_human def: "Mitogen-activated protein kinase 13 gene" [UniProtKB:O15264] synonym: "PRKM13" EXACT [UniProtKB:O15264] synonym: "SAPK4" EXACT [UniProtKB:O15264] xref: EMBL:AF004709 xref: EMBL:AF015256 xref: EMBL:AF092535 xref: EMBL:AF100546 xref: EMBL:BC000433 xref: EMBL:BC001641 xref: EMBL:BC004428 xref: EMBL:BT007221 xref: EMBL:U93232 xref: EMBL:Y10488 xref: EMBL:Z95152 xref: HGNC:HGNC:6875 xref: UniGene:Hs.178695 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001369 ! MK13_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005099 name: MLF1_human def: "Myeloid leukemia factor 1 gene" [UniProtKB:P58340] xref: EMBL:BC007045 xref: EMBL:L49054 xref: HGNC:HGNC:7125 xref: UniGene:Hs.85195 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001684 ! MLF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005100 name: MLH1_human def: "DNA mismatch repair protein Mlh1 gene" [UniProtKB:P40692] synonym: "COCA2" EXACT [UniProtKB:P40692] xref: EMBL:AY217549 xref: EMBL:BC006850 xref: EMBL:U07343 xref: EMBL:U07418 xref: EMBL:U17839 xref: EMBL:U17840 xref: EMBL:U17841 xref: EMBL:U17842 xref: EMBL:U17843 xref: EMBL:U17844 xref: EMBL:U17845 xref: EMBL:U17846 xref: EMBL:U17847 xref: EMBL:U17848 xref: EMBL:U17849 xref: EMBL:U17851 xref: EMBL:U17852 xref: EMBL:U17853 xref: EMBL:U17854 xref: EMBL:U17855 xref: EMBL:U17856 xref: EMBL:U17857 xref: EMBL:U40960 xref: EMBL:U40961 xref: EMBL:U40962 xref: EMBL:U40963 xref: EMBL:U40964 xref: EMBL:U40965 xref: EMBL:U40966 xref: EMBL:U40967 xref: EMBL:U40968 xref: EMBL:U40969 xref: EMBL:U40970 xref: EMBL:U40971 xref: EMBL:U40972 xref: EMBL:U40973 xref: EMBL:U40974 xref: EMBL:U40975 xref: EMBL:U40976 xref: EMBL:U40977 xref: EMBL:U40978 xref: HGNC:HGNC:7127 xref: UniGene:Hs.195364 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001601 ! MLH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005101 name: MLH3_human def: "DNA mismatch repair protein Mlh3 gene" [UniProtKB:Q9UHC1] xref: EMBL:AB039667 xref: EMBL:AF195657 xref: EMBL:AF195658 xref: EMBL:AY963685 xref: EMBL:L40399 xref: HGNC:HGNC:7128 xref: UniGene:Hs.436650 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002200 ! MLH3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005102 name: MAP1LC3A_human def: "Microtubule-associated proteins 1A/1B light chain 3A precursor gene" [UniProtKB:Q9H492] xref: EMBL:AF276658 xref: EMBL:AL118520 xref: EMBL:AL833855 xref: EMBL:BC015810 xref: EMBL:BT007452 xref: HGNC:HGNC:6838 xref: UniGene:Hs.632273 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006281 ! MLP3A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005103 name: MAP1LC3B_human def: "Microtubule-associated proteins 1A/1B light chain 3B precursor gene" [UniProtKB:Q9GZQ8] synonym: "MAP1ALC3" EXACT [UniProtKB:Q9GZQ8] xref: EMBL:AF087871 xref: EMBL:AF183417 xref: EMBL:AF303888 xref: EMBL:AK025556 xref: EMBL:BC018634 xref: EMBL:BC041874 xref: EMBL:BC067797 xref: HGNC:HGNC:13352 xref: UniGene:Hs.356061 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006342 ! MLP3B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005104 name: MRLC2_human def: "Myosin regulatory light chain 2, nonsarcomeric gene" [UniProtKB:P19105] synonym: "MLCB" EXACT [UniProtKB:P19105] synonym: "RLC" EXACT [UniProtKB:P19105] xref: EMBL:BC016372 xref: EMBL:BC031972 xref: EMBL:BC032748 xref: EMBL:X54304 xref: UniGene:Hs.190086 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005759 ! MLRM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005105 name: MLTK_human def: "Mitogen-activated protein kinase kinase kinase MLT gene" [UniProtKB:Q9NYL2] synonym: "HCCS4" EXACT [UniProtKB:Q9NYL2] synonym: "ZAK" EXACT [UniProtKB:Q9NYL2] xref: EMBL:AB030034 xref: EMBL:AB049733 xref: EMBL:AB049734 xref: EMBL:AB208974 xref: EMBL:AC013461 xref: EMBL:AC019046 xref: EMBL:AC092573 xref: EMBL:AF238255 xref: EMBL:AF251441 xref: EMBL:AF325454 xref: EMBL:AF465843 xref: EMBL:AF480461 xref: EMBL:AF480462 xref: EMBL:BC001401 xref: UniGene:Hs.444451 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002178 ! MLTK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005106 name: MNS1_human def: "Meiosis-specific nuclear structural protein 1 gene" [UniProtKB:Q8NEH6] xref: EMBL:AK002084 xref: EMBL:BC031046 xref: EMBL:BC034991 xref: HGNC:HGNC:29636 xref: UniGene:Hs.444483 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001979 ! MNS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005108 name: MORF4L1_human def: "Mortality factor 4-like protein 1 gene" [UniProtKB:Q9UBU8] synonym: "FWP006" EXACT [UniProtKB:Q9UBU8] synonym: "HSPC008" EXACT [UniProtKB:Q9UBU8] synonym: "HSPC061" EXACT [UniProtKB:Q9UBU8] synonym: "MRG15" EXACT [UniProtKB:Q9UBU8] synonym: "PP368" EXACT [UniProtKB:Q9UBU8] xref: EMBL:AF070664 xref: EMBL:AF100615 xref: EMBL:AF109188 xref: EMBL:AF131847 xref: EMBL:AF161546 xref: EMBL:AF167173 xref: EMBL:AF218011 xref: EMBL:AL137697 xref: EMBL:AY148481 xref: EMBL:BC002936 xref: EMBL:BC022845 xref: EMBL:BC067826 xref: HGNC:HGNC:16989 xref: UniGene:Hs.374503 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005917 ! MO4L1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005109 name: MORF4L2_human def: "Mortality factor 4-like protein 2 gene" [UniProtKB:Q15014] synonym: "KIAA0026" EXACT [UniProtKB:Q15014] synonym: "MRGX" EXACT [UniProtKB:Q15014] xref: EMBL:AB050778 xref: EMBL:AF100620 xref: EMBL:AF167174 xref: EMBL:AL049610 xref: EMBL:BC056899 xref: EMBL:BC093013 xref: EMBL:D14812 xref: HGNC:HGNC:16849 xref: UniGene:Hs.326387 xref: UniGene:Hs.597035 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005370 ! MO4L2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005111 name: MON1A_human def: "Vacuolar fusion protein MON1 homolog A gene" [UniProtKB:Q86VX9] synonym: "SAND1" EXACT [UniProtKB:Q86VX9] xref: EMBL:AK092018 xref: EMBL:BC006299 xref: EMBL:BC009459 xref: EMBL:BC047022 xref: HGNC:HGNC:28207 xref: UniGene:Hs.655014 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005970 ! MON1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005114 name: MAP2K6_human def: "Dual specificity mitogen-activated protein kinase kinase 6 gene" [UniProtKB:P52564] synonym: "MEK6" EXACT [UniProtKB:P52564] synonym: "MKK6" EXACT [UniProtKB:P52564] synonym: "PRKMK6" EXACT [UniProtKB:P52564] xref: EMBL:BC012009 xref: EMBL:D87905 xref: EMBL:U39064 xref: EMBL:U39065 xref: EMBL:U39656 xref: EMBL:U39657 xref: EMBL:U49732 xref: EMBL:X96757 xref: HGNC:HGNC:6846 xref: UniGene:Hs.463978 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001658 ! MP2K6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005115 name: SLC25A3_human def: "Phosphate carrier protein, mitochondrial precursor gene" [UniProtKB:Q00325] synonym: "OK/SW-cl.48" EXACT [UniProtKB:Q00325] synonym: "PHC" EXACT [UniProtKB:Q00325] xref: EMBL:AB064666 xref: EMBL:BC000998 xref: EMBL:BC001328 xref: EMBL:BC003504 xref: EMBL:BC004345 xref: EMBL:BC006455 xref: EMBL:BC011574 xref: EMBL:BC011641 xref: EMBL:BC014019 xref: EMBL:BC015379 xref: EMBL:X60036 xref: EMBL:X77337 xref: HGNC:HGNC:10989 xref: UniGene:Hs.290404 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005847 ! MPCP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005116 name: MPHOSPH6_human def: "M-phase phosphoprotein 6 gene" [UniProtKB:Q99547] synonym: "MPP6" EXACT [UniProtKB:Q99547] xref: EMBL:BC005242 xref: EMBL:BC011020 xref: EMBL:BC031017 xref: EMBL:X98263 xref: HGNC:HGNC:7214 xref: UniGene:Hs.344400 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002071 ! MPH6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005117 name: CDC25A_human def: "M-phase inducer phosphatase 1 gene" [UniProtKB:P30304] xref: EMBL:AF277722 xref: EMBL:AF527417 xref: EMBL:AY137580 xref: EMBL:BC007401 xref: EMBL:BC018642 xref: EMBL:M81933 xref: HGNC:HGNC:1725 xref: UniGene:Hs.437705 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001576 ! MPIP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005118 name: CDC25B_human def: "M-phase inducer phosphatase 2 gene" [UniProtKB:P30305] synonym: "CDC25HU2" EXACT [UniProtKB:P30305] xref: EMBL:AF036233 xref: EMBL:AL109804 xref: EMBL:AY494082 xref: EMBL:BC006395 xref: EMBL:BC009953 xref: EMBL:BC051711 xref: EMBL:M81934 xref: EMBL:S78187 xref: EMBL:X96436 xref: EMBL:Z68092 xref: HGNC:HGNC:1726 xref: UniGene:Hs.153752 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001393 ! O43550_HUMAN relationship: codes_for CCO:B0001577 ! MPIP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005119 name: CDC25C_human def: "M-phase inducer phosphatase 3 gene" [UniProtKB:P30307] xref: EMBL:AF277723 xref: EMBL:AF277724 xref: EMBL:AF277725 xref: EMBL:AF277726 xref: EMBL:AF312681 xref: EMBL:AJ304504 xref: EMBL:AY497474 xref: EMBL:BC019089 xref: EMBL:M34065 xref: HGNC:HGNC:1727 xref: UniGene:Hs.656 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001578 ! MPIP3_HUMAN relationship: codes_for CCO:B0002127 ! Q9H2F0_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005120 name: MPP3_human def: "MAGUK p55 subfamily member 3 gene" [UniProtKB:Q13368] synonym: "DLG3" EXACT [UniProtKB:Q13368] xref: EMBL:AM050144 xref: EMBL:AM050145 xref: EMBL:BC047017 xref: EMBL:BC056865 xref: EMBL:U37707 xref: HGNC:HGNC:7221 xref: UniGene:Hs.396566 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006207 ! MPP3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005121 name: MPHOSPH8_human def: "M-phase phosphoprotein 8 gene" [UniProtKB:Q99549] synonym: "MPP8" EXACT [UniProtKB:Q99549] xref: EMBL:AK056785 xref: EMBL:AL354808 xref: EMBL:AL359457 xref: EMBL:AL832864 xref: EMBL:BC003542 xref: EMBL:BC046214 xref: EMBL:CH471075 xref: EMBL:X98259 xref: HGNC:HGNC:29810 xref: UniGene:Hs.269654 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002072 ! MPP8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005123 name: MPHOSPH1_human def: "M-phase phosphoprotein 1 gene" [UniProtKB:Q96Q89] synonym: "KRMP1" EXACT [UniProtKB:Q96Q89] xref: EMBL:AB033337 xref: EMBL:AB033338 xref: EMBL:AK024959 xref: EMBL:AK025628 xref: EMBL:AL117496 xref: EMBL:AL137392 xref: EMBL:AL157389 xref: EMBL:AL157400 xref: EMBL:AY282406 xref: EMBL:AY282407 xref: EMBL:AY739715 xref: EMBL:BC012585 xref: EMBL:BC046134 xref: EMBL:BC058913 xref: EMBL:BC093089 xref: EMBL:BC108688 xref: EMBL:L16782 xref: EMBL:U93121 xref: HGNC:HGNC:7212 xref: UniGene:Hs.240 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002056 ! MPPH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005124 name: MRE11A_human def: "Double-strand break repair protein MRE11A gene" [UniProtKB:P49959] synonym: "HNGS1" EXACT [UniProtKB:P49959] synonym: "MRE11" EXACT [UniProtKB:P49959] xref: EMBL:AF022778 xref: EMBL:AF073362 xref: EMBL:AF303379 xref: EMBL:AF303380 xref: EMBL:AF303381 xref: EMBL:AF303382 xref: EMBL:AF303383 xref: EMBL:AF303384 xref: EMBL:AF303385 xref: EMBL:AF303386 xref: EMBL:AF303387 xref: EMBL:AF303388 xref: EMBL:AF303389 xref: EMBL:AF303390 xref: EMBL:AF303391 xref: EMBL:AF303392 xref: EMBL:AF303393 xref: EMBL:AF303394 xref: EMBL:AF303395 xref: EMBL:AY584241 xref: EMBL:BC063458 xref: EMBL:U37359 xref: HGNC:HGNC:7230 xref: UniGene:Hs.192649 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001641 ! MRE11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005125 name: MRGBP_human def: "MRG-binding protein gene" [UniProtKB:Q9NV56] synonym: "C20orf20" EXACT [UniProtKB:Q9NV56] xref: EMBL:AK001776 xref: EMBL:AL035669 xref: EMBL:BC009889 xref: EMBL:BC014235 xref: EMBL:BC018841 xref: HGNC:HGNC:15866 xref: UniGene:Hs.590870 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005360 ! MRGBP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005126 name: MSH2_human def: "DNA mismatch repair protein Msh2 gene" [UniProtKB:P43246] xref: EMBL:AF066081 xref: EMBL:AY601851 xref: EMBL:BC021566 xref: EMBL:L47581 xref: EMBL:L47582 xref: EMBL:L47583 xref: EMBL:U03911 xref: EMBL:U04045 xref: EMBL:U41206 xref: EMBL:U41207 xref: EMBL:U41208 xref: EMBL:U41210 xref: EMBL:U41211 xref: EMBL:U41212 xref: EMBL:U41213 xref: EMBL:U41214 xref: EMBL:U41215 xref: EMBL:U41216 xref: EMBL:U41217 xref: EMBL:U41218 xref: EMBL:U41219 xref: EMBL:U41220 xref: EMBL:U41221 xref: HGNC:HGNC:7325 xref: UniGene:Hs.597656 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001620 ! MSH2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005127 name: MSH3_human def: "DNA mismatch repair protein Msh3 gene" [UniProtKB:P20585] synonym: "DUC1" EXACT [UniProtKB:P20585] synonym: "DUG" EXACT [UniProtKB:P20585] xref: EMBL:AY275681 xref: EMBL:BC011817 xref: EMBL:D61419 xref: EMBL:J04810 xref: EMBL:U61981 xref: HGNC:HGNC:7326 xref: UniGene:Hs.280987 xref: UniGene:Hs.648635 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005720 ! MSH3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005128 name: MSH4_human def: "MutS protein homolog 4 gene" [UniProtKB:O15457] xref: EMBL:AF104243 xref: EMBL:AY268350 xref: EMBL:BC033030 xref: EMBL:U89293 xref: HGNC:HGNC:7327 xref: UniGene:Hs.216639 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001378 ! MSH4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005129 name: MSH5_human def: "MutS protein homolog 5 gene" [UniProtKB:O43196] xref: EMBL:AF034759 xref: EMBL:AF048986 xref: EMBL:AF048988 xref: EMBL:AF048989 xref: EMBL:AF048990 xref: EMBL:AF048991 xref: EMBL:AF070071 xref: EMBL:AF070072 xref: EMBL:AF070073 xref: EMBL:AF070074 xref: EMBL:AF070075 xref: EMBL:AF070076 xref: EMBL:AF070077 xref: EMBL:AF070078 xref: EMBL:AF070079 xref: EMBL:AF129756 xref: EMBL:AF134726 xref: EMBL:AL662834 xref: EMBL:AL662899 xref: EMBL:AY943816 xref: EMBL:BA000025 xref: EMBL:BC001358 xref: EMBL:BC002498 xref: EMBL:BC041031 xref: EMBL:BT007200 xref: HGNC:HGNC:7328 xref: UniGene:Hs.371225 xref: UniGene:Hs.647011 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001381 ! MSH5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005130 name: MSH6_human def: "DNA mismatch repair protein Msh6 gene" [UniProtKB:P52701] synonym: "GTBP" EXACT [UniProtKB:P52701] xref: EMBL:AY082894 xref: EMBL:BC004246 xref: EMBL:D89645 xref: EMBL:D89646 xref: EMBL:U28946 xref: EMBL:U54777 xref: EMBL:U73732 xref: EMBL:U73733 xref: EMBL:U73734 xref: EMBL:U73736 xref: EMBL:U73737 xref: HGNC:HGNC:7329 xref: UniGene:Hs.445052 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005639 ! MSH6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005132 name: MTFR1_human def: "Mitochondrial fission regulator 1 gene" [UniProtKB:Q15390] synonym: "CHPPR" EXACT [UniProtKB:Q15390] synonym: "KIAA0009" EXACT [UniProtKB:Q15390] xref: EMBL:BC036116 xref: EMBL:BC043498 xref: EMBL:CR456910 xref: EMBL:D13634 xref: HGNC:HGNC:29510 xref: UniGene:Hs.654531 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006321 ! MTFR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005133 name: MTMR6_human def: "Myotubularin-related protein 6 gene" [UniProtKB:Q9Y217] xref: EMBL:AF072928 xref: EMBL:AF406619 xref: EMBL:AL590787 xref: EMBL:AL832017 xref: EMBL:BC040012 xref: HGNC:HGNC:7453 xref: UniGene:Hs.643702 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006052 ! MTMR6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005134 name: MTNR1A_human def: "Melatonin receptor type 1A gene" [UniProtKB:P48039] xref: EMBL:AB029933 xref: EMBL:BC074946 xref: EMBL:BC074947 xref: EMBL:BC126297 xref: EMBL:BC126299 xref: EMBL:U14108 xref: HGNC:HGNC:7463 xref: UniGene:Hs.243467 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005723 ! MTR1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005135 name: MTNR1B_human def: "Melatonin receptor type 1B gene" [UniProtKB:P49286] xref: EMBL:AB033598 xref: EMBL:AY521019 xref: EMBL:BC069163 xref: EMBL:U25341 xref: HGNC:HGNC:7464 xref: UniGene:Hs.569039 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005724 ! MTR1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005136 name: MTSS1_human def: "Metastasis suppressor protein 1 gene" [UniProtKB:O43312] synonym: "KIAA0429" EXACT [UniProtKB:O43312] synonym: "MIM" EXACT [UniProtKB:O43312] xref: EMBL:AB007889 xref: EMBL:AF086645 xref: EMBL:AK027015 xref: EMBL:BC023998 xref: HGNC:HGNC:20443 xref: UniGene:Hs.336994 xref: UniGene:Hs.700429 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001390 ! MTSS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005137 name: MTUS1_human def: "Mitochondrial tumor suppressor 1 gene" [UniProtKB:Q9ULD2] synonym: "ATIP" EXACT [UniProtKB:Q9ULD2] synonym: "GK1" EXACT [UniProtKB:Q9ULD2] synonym: "KIAA1288" EXACT [UniProtKB:Q9ULD2] synonym: "MTSG1" EXACT [UniProtKB:Q9ULD2] xref: EMBL:AB033114 xref: EMBL:AF121259 xref: EMBL:AF293357 xref: EMBL:AK024357 xref: EMBL:AK125188 xref: EMBL:AL096842 xref: EMBL:AY363099 xref: EMBL:BC007328 xref: EMBL:BC033842 xref: EMBL:BC142971 xref: EMBL:BX648879 xref: HGNC:HGNC:29789 xref: UniGene:Hs.7946 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002224 ! MTUS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005138 name: MUTYH_human def: "A/G-specific adenine DNA glycosylase gene" [UniProtKB:Q9UIF7] synonym: "MYH" EXACT [UniProtKB:Q9UIF7] xref: EMBL:AB032920 xref: EMBL:AB032921 xref: EMBL:AB032922 xref: EMBL:AB032923 xref: EMBL:AB032924 xref: EMBL:AB032925 xref: EMBL:AB032926 xref: EMBL:AB032927 xref: EMBL:AB032928 xref: EMBL:AB032929 xref: EMBL:AF527839 xref: EMBL:AL359540 xref: EMBL:BC003178 xref: EMBL:U63329 xref: HGNC:HGNC:7527 xref: UniGene:Hs.271353 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002205 ! MUTYH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005142 name: MYC_human def: "Myc proto-oncogene protein gene" [UniProtKB:P01106] xref: EMBL:AY214166 xref: EMBL:BC000141 xref: EMBL:BC000917 xref: EMBL:BC058901 xref: EMBL:BT019768 xref: EMBL:D10493 xref: EMBL:K00534 xref: EMBL:K00535 xref: EMBL:K01905 xref: EMBL:K01906 xref: EMBL:K02276 xref: EMBL:L00057 xref: EMBL:L00058 xref: EMBL:M13929 xref: EMBL:V00568 xref: EMBL:X00196 xref: EMBL:X00198 xref: EMBL:X00364 xref: EMBL:X00676 xref: HGNC:HGNC:7553 xref: UniGene:Hs.202453 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001465 ! MYC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005143 name: MYH14_human def: "Myosin-14 gene" [UniProtKB:Q7Z406] synonym: "FP17425" EXACT [UniProtKB:Q7Z406] synonym: "KIAA2034" EXACT [UniProtKB:Q7Z406] xref: EMBL:AB111886 xref: EMBL:AK023943 xref: EMBL:AY165122 xref: EMBL:AY203926 xref: EMBL:BC000676 xref: EMBL:BC004396 xref: EMBL:BC007877 xref: EMBL:BC018933 xref: EMBL:CR936653 xref: HGNC:HGNC:23212 xref: UniGene:Hs.467142 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005971 ! MYH14_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005144 name: MYL6_human def: "Myosin light polypeptide 6 gene" [UniProtKB:P60660] xref: EMBL:AB046613 xref: EMBL:BC006781 xref: EMBL:BC017455 xref: EMBL:BC071661 xref: EMBL:CR457014 xref: EMBL:M22918 xref: EMBL:M22919 xref: EMBL:M22920 xref: EMBL:M31212 xref: EMBL:U02629 xref: HGNC:HGNC:7587 xref: UniGene:Hs.632717 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005743 ! MYL6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005145 name: MYO16_human def: "Myosin-XVI gene" [UniProtKB:Q9Y6X6] synonym: "KIAA0865" EXACT [UniProtKB:Q9Y6X6] synonym: "MYO16B" EXACT [UniProtKB:Q9Y6X6] xref: EMBL:AB020672 xref: EMBL:AK095691 xref: EMBL:AK127806 xref: EMBL:AL136132 xref: EMBL:AL157771 xref: EMBL:AL161431 xref: EMBL:AL353143 xref: EMBL:AL390918 xref: EMBL:AL834447 xref: HGNC:HGNC:29822 xref: UniGene:Hs.656587 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002267 ! MYO16_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005147 name: MYOD1_human def: "Myoblast determination protein 1 gene" [UniProtKB:P15172] synonym: "MYF3" EXACT [UniProtKB:P15172] synonym: "MYOD" EXACT [UniProtKB:P15172] xref: EMBL:X17650 xref: EMBL:X56677 xref: HGNC:HGNC:7611 xref: UniGene:Hs.181768 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005705 ! MYOD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005150 name: MPZ_human def: "Myelin P0 protein precursor gene" [UniProtKB:P25189] xref: EMBL:BC006491 xref: EMBL:BT006765 xref: EMBL:D10537 xref: EMBL:D14720 xref: EMBL:L24893 xref: EMBL:L24894 xref: EMBL:S66705 xref: EMBL:U10017 xref: EMBL:U10018 xref: HGNC:HGNC:7225 xref: UniGene:Hs.591486 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006337 ! MYP0_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005151 name: MYST2_human def: "Histone acetyltransferase MYST2 gene" [UniProtKB:O95251] synonym: "HBO1" EXACT [UniProtKB:O95251] synonym: "HBOa" EXACT [UniProtKB:O95251] xref: EMBL:AF074606 xref: EMBL:AF140360 xref: EMBL:AF217502 xref: EMBL:BC032640 xref: HGNC:HGNC:17016 xref: UniGene:Hs.21907 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005399 ! MYST2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005152 name: MYT1L_human def: "Myelin transcription factor 1-like protein gene" [UniProtKB:Q9UL68] synonym: "KIAA1106" EXACT [UniProtKB:Q9UL68] xref: EMBL:AB029029 xref: EMBL:AF036943 xref: EMBL:BC071612 xref: HGNC:HGNC:7623 xref: UniGene:Hs.434418 xref: UniGene:Hs.669852 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005601 ! MYT1L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005153 name: MYT1_human def: "Myelin transcription factor 1 gene" [UniProtKB:Q01538] synonym: "KIAA0835" EXACT [UniProtKB:Q01538] synonym: "KIAA1050" EXACT [UniProtKB:Q01538] synonym: "MTF1" EXACT [UniProtKB:Q01538] synonym: "MYTI" EXACT [UniProtKB:Q01538] synonym: "PLPB1" EXACT [UniProtKB:Q01538] xref: EMBL:AB020642 xref: EMBL:AB028973 xref: EMBL:AL121581 xref: EMBL:M96980 xref: HGNC:HGNC:7622 xref: UniGene:Hs.279562 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005607 ! MYT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005154 name: NACA_human def: "Nascent polypeptide-associated complex subunit alpha gene" [UniProtKB:Q13765] synonym: "HSD48" EXACT [UniProtKB:Q13765] xref: EMBL:AF054187 xref: EMBL:AK223085 xref: EMBL:AY034001 xref: EMBL:AY605660 xref: EMBL:AY911673 xref: EMBL:BC105120 xref: EMBL:BC105122 xref: EMBL:BC106041 xref: EMBL:CR450295 xref: EMBL:X80909 xref: HGNC:HGNC:7629 xref: UniGene:Hs.505735 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006096 ! NACA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005155 name: QPRT_human def: "Nicotinate-nucleotide pyrophosphorylase [carboxylating] gene" [UniProtKB:Q15274] xref: EMBL:BC005060 xref: EMBL:BC010033 xref: EMBL:BC018910 xref: EMBL:BT007231 xref: EMBL:D78177 xref: HGNC:HGNC:9755 xref: UniGene:Hs.513484 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005174 ! NADC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005156 name: NASP_human def: "Nuclear autoantigenic sperm protein gene" [UniProtKB:P49321] xref: EMBL:AK222816 xref: EMBL:AL355480 xref: EMBL:BC003113 xref: EMBL:BC010105 xref: EMBL:BC011580 xref: EMBL:BC053608 xref: EMBL:M97856 xref: HGNC:HGNC:7644 xref: UniGene:Hs.319334 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001626 ! NASP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005157 name: NAT6_human def: "N-acetyltransferase 6 gene" [UniProtKB:Q93015] synonym: "FUS2" EXACT [UniProtKB:Q93015] xref: EMBL:AF040705 xref: EMBL:AF040706 xref: EMBL:BC004483 xref: EMBL:U73167 xref: HGNC:HGNC:30252 xref: UniGene:Hs.129910 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002026 ! NAT6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005158 name: NBL1_human def: "Neuroblastoma suppressor of tumorigenicity 1 precursor gene" [UniProtKB:P41271] synonym: "DAN" EXACT [UniProtKB:P41271] synonym: "DAND1" EXACT [UniProtKB:P41271] xref: EMBL:AY049783 xref: EMBL:BC012037 xref: EMBL:D28124 xref: EMBL:D89013 xref: HGNC:HGNC:7650 xref: UniGene:Hs.466662 xref: UniGene:Hs.654502 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001607 ! NBL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005159 name: NBN_human def: "Nibrin gene" [UniProtKB:O60934] synonym: "NBS" EXACT [UniProtKB:O60934] synonym: "NBS1" EXACT [UniProtKB:O60934] synonym: "P95" EXACT [UniProtKB:O60934] xref: EMBL:AB013139 xref: EMBL:AF051334 xref: EMBL:AF058696 xref: EMBL:AF069291 xref: EMBL:AK223256 xref: EMBL:AY566246 xref: EMBL:BC108650 xref: EMBL:BX640816 xref: HGNC:HGNC:7652 xref: UniGene:Hs.492208 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001421 ! NBN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005160 name: NCOA6_human def: "Nuclear receptor coactivator 6 gene" [UniProtKB:Q14686] synonym: "AIB3" EXACT [UniProtKB:Q14686] synonym: "KIAA0181" EXACT [UniProtKB:Q14686] synonym: "RAP250" EXACT [UniProtKB:Q14686] synonym: "TRBP" EXACT [UniProtKB:Q14686] xref: EMBL:AF128458 xref: EMBL:AF171667 xref: EMBL:AF177388 xref: EMBL:AF208227 xref: EMBL:AF245115 xref: EMBL:AL109824 xref: EMBL:CH471077 xref: EMBL:D80003 xref: HGNC:HGNC:15936 xref: UniGene:Hs.368971 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005893 ! NCOA6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005161 name: NCOA7_human def: "Nuclear receptor coactivator 7 gene" [UniProtKB:Q8NI08] synonym: "ERAP140" EXACT [UniProtKB:Q8NI08] synonym: "ESNA1" EXACT [UniProtKB:Q8NI08] synonym: "Nbla00052" EXACT [UniProtKB:Q8NI08] synonym: "Nbla10993" EXACT [UniProtKB:Q8NI08] xref: EMBL:AB074157 xref: EMBL:AF493978 xref: EMBL:AK094706 xref: EMBL:AL035689 xref: EMBL:AL078594 xref: EMBL:AL136163 xref: EMBL:AL832628 xref: EMBL:BC036461 xref: EMBL:BC071782 xref: EMBL:BX537385 xref: HGNC:HGNC:21081 xref: UniGene:Hs.171426 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005552 ! NCOA7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005162 name: NCOR2_human def: "Nuclear receptor corepressor 2 gene" [UniProtKB:Q9Y618] synonym: "CTG26" EXACT [UniProtKB:Q9Y618] xref: EMBL:AF113003 xref: EMBL:AF125672 xref: EMBL:S83390 xref: EMBL:U37146 xref: EMBL:U80750 xref: HGNC:HGNC:7673 xref: UniGene:Hs.137510 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005553 ! NCOR2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005163 name: NDE1_human def: "Nuclear distribution protein nudE homolog 1 gene" [UniProtKB:Q9NXR1] synonym: "NUDE" EXACT [UniProtKB:Q9NXR1] xref: EMBL:AC026401 xref: EMBL:AF001548 xref: EMBL:AK000108 xref: EMBL:BC001421 xref: EMBL:BC033900 xref: HGNC:HGNC:17619 xref: UniGene:Hs.655378 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002173 ! NDE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005164 name: NDEL1_human def: "Nuclear distribution protein nudE-like 1 gene" [UniProtKB:Q9GZM8] synonym: "EOPA" EXACT [UniProtKB:Q9GZM8] synonym: "MITAP1" EXACT [UniProtKB:Q9GZM8] synonym: "NUDEL" EXACT [UniProtKB:Q9GZM8] xref: EMBL:AF182078 xref: EMBL:AF217798 xref: EMBL:AL832648 xref: EMBL:AY004871 xref: EMBL:BC026101 xref: HGNC:HGNC:17620 xref: UniGene:Hs.372123 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005926 ! NDEL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005165 name: NME3_human def: "Nucleoside diphosphate kinase 3 gene" [UniProtKB:Q13232] xref: EMBL:AE006639 xref: EMBL:BC000250 xref: EMBL:U29656 xref: HGNC:HGNC:7851 xref: UniGene:Hs.514065 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005316 ! NDK3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005166 name: NME7_human def: "Nucleoside diphosphate kinase 7 gene" [UniProtKB:Q9Y5B8] xref: EMBL:AF153191 xref: EMBL:AL031726 xref: EMBL:AL356852 xref: EMBL:BC006983 xref: EMBL:Z99758 xref: HGNC:HGNC:20461 xref: UniGene:Hs.702359 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005294 ! NDK7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005167 name: NME1_human def: "Nucleoside diphosphate kinase A gene" [UniProtKB:P15531] synonym: "NDPKA" EXACT [UniProtKB:P15531] synonym: "NM23" EXACT [UniProtKB:P15531] xref: EMBL:BC000293 xref: EMBL:BC018994 xref: EMBL:X17620 xref: EMBL:X73066 xref: EMBL:X75598 xref: HGNC:HGNC:7849 xref: UniGene:Hs.463456 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001524 ! NDKA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005168 name: NME2_human def: "Nucleoside diphosphate kinase B gene" [UniProtKB:P22392] synonym: "NM23B" EXACT [UniProtKB:P22392] xref: EMBL:BC002476 xref: EMBL:L16785 xref: EMBL:M36981 xref: EMBL:X58965 xref: HGNC:HGNC:7850 xref: UniGene:Hs.463456 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001546 ! NDKB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005169 name: NME4_human def: "Nucleoside diphosphate kinase, mitochondrial precursor gene" [UniProtKB:O00746] synonym: "NM23D" EXACT [UniProtKB:O00746] xref: EMBL:AE006463 xref: EMBL:BC004880 xref: EMBL:BC017067 xref: EMBL:Y07604 xref: EMBL:Z97634 xref: HGNC:HGNC:7852 xref: UniGene:Hs.9235 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005206 ! NDKM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005170 name: NDUFB8_human def: "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor gene" [UniProtKB:O95169] xref: EMBL:AF044958 xref: EMBL:AF077028 xref: EMBL:AF115968 xref: EMBL:AL080056 xref: EMBL:AL133352 xref: EMBL:BC000466 xref: EMBL:BC019276 xref: EMBL:CR533490 xref: EMBL:Y18944 xref: HGNC:HGNC:7703 xref: UniGene:Hs.523215 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006289 ! NDUB8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005171 name: PPP1R9B_human def: "Neurabin-2 gene" [UniProtKB:Q96SB3] synonym: "PPP1R6" EXACT [UniProtKB:Q96SB3] xref: EMBL:AJ401189 xref: EMBL:AL713642 xref: HGNC:HGNC:9298 xref: UniGene:Hs.514323 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002060 ! NEB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005173 name: NEDD8_human def: "NEDD8 precursor gene" [UniProtKB:Q15843] xref: EMBL:BC104200 xref: EMBL:BC104201 xref: EMBL:BC104664 xref: EMBL:CR407662 xref: EMBL:D23662 xref: HGNC:HGNC:7732 xref: UniGene:Hs.531064 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005331 ! NEDD8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005174 name: NEK11_human def: "Serine/threonine-protein kinase Nek11 gene" [UniProtKB:Q8NG66] xref: EMBL:AB071996 xref: EMBL:AB071997 xref: EMBL:AK027148 xref: EMBL:AL833472 xref: EMBL:BC028587 xref: HGNC:HGNC:18593 xref: UniGene:Hs.657336 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001984 ! NEK11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005175 name: NEK1_human def: "Serine/threonine-protein kinase Nek1 gene" [UniProtKB:Q96PY6] synonym: "KIAA1901" EXACT [UniProtKB:Q96PY6] xref: EMBL:AB067488 xref: EMBL:AF155113 xref: HGNC:HGNC:7744 xref: UniGene:Hs.481181 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002055 ! NEK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005176 name: NEK2_human def: "Serine/threonine-protein kinase Nek2 gene" [UniProtKB:P51955] synonym: "NLK1" EXACT [UniProtKB:P51955] xref: EMBL:AC096637 xref: EMBL:AK223353 xref: EMBL:AL356310 xref: EMBL:AY045701 xref: EMBL:BC043502 xref: EMBL:BC052807 xref: EMBL:BC065932 xref: EMBL:BT019729 xref: EMBL:U11050 xref: EMBL:Z25425 xref: EMBL:Z29066 xref: HGNC:HGNC:7745 xref: UniGene:Hs.153704 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001654 ! NEK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005177 name: NEK4_human def: "Serine/threonine-protein kinase Nek4 gene" [UniProtKB:P51957] synonym: "STK2" EXACT [UniProtKB:P51957] xref: EMBL:L20321 xref: HGNC:HGNC:11399 xref: UniGene:Hs.631921 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001655 ! NEK4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005178 name: NEK6_human def: "Serine/threonine-protein kinase Nek6 gene" [UniProtKB:Q9HC98] xref: EMBL:AB026289 xref: EMBL:AF087909 xref: EMBL:BC000101 xref: EMBL:BC004174 xref: EMBL:BC004209 xref: EMBL:BC012761 xref: HGNC:HGNC:7749 xref: UniGene:Hs.197071 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002145 ! NEK6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005179 name: NEK9_human def: "Serine/threonine-protein kinase Nek9 gene" [UniProtKB:Q8TD19] synonym: "KIAA1995" EXACT [UniProtKB:Q8TD19] synonym: "NEK8" EXACT [UniProtKB:Q8TD19] synonym: "NERCC" EXACT [UniProtKB:Q8TD19] xref: EMBL:AB082526 xref: EMBL:AC007055 xref: EMBL:AY048580 xref: EMBL:AY080896 xref: EMBL:BC009336 xref: EMBL:BC093881 xref: EMBL:BC112101 xref: HGNC:HGNC:18591 xref: UniGene:Hs.696132 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001991 ! NEK9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005180 name: NELF_human def: "Nasal embryonic luteinizing hormone-releasing hormone factor gene" [UniProtKB:Q6X4W1] xref: EMBL:AK027474 xref: EMBL:AK074602 xref: EMBL:AL365502 xref: EMBL:AL389944 xref: EMBL:AL389945 xref: EMBL:AL389946 xref: EMBL:AY255128 xref: EMBL:AY255129 xref: EMBL:AY255130 xref: EMBL:AY255131 xref: EMBL:AY255132 xref: EMBL:BC072412 xref: HGNC:HGNC:29843 xref: UniGene:Hs.455336 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005972 ! NELF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005181 name: NELL1_human def: "Protein kinase C-binding protein NELL1 precursor gene" [UniProtKB:Q92832] synonym: "NRP1" EXACT [UniProtKB:Q92832] xref: EMBL:BC096101 xref: EMBL:D83017 xref: EMBL:U57523 xref: HGNC:HGNC:7750 xref: UniGene:Hs.657172 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005973 ! NELL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005182 name: NELL2_human def: "Protein kinase C-binding protein NELL2 precursor gene" [UniProtKB:Q99435] synonym: "NRP2" EXACT [UniProtKB:Q99435] xref: EMBL:BC020544 xref: EMBL:D83018 xref: HGNC:HGNC:7751 xref: UniGene:Hs.505326 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005427 ! NELL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005183 name: IKBKG_human def: "NF-kappa-B essential modulator gene" [UniProtKB:Q9Y6K9] synonym: "FIP3" EXACT [UniProtKB:Q9Y6K9] synonym: "NEMO" EXACT [UniProtKB:Q9Y6K9] xref: EMBL:AF062089 xref: EMBL:AF074382 xref: EMBL:AF091453 xref: EMBL:AF261086 xref: EMBL:AJ271718 xref: EMBL:BC000299 xref: EMBL:BC012114 xref: EMBL:BC050612 xref: EMBL:BT019621 xref: HGNC:HGNC:5961 xref: UniGene:Hs.43505 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005524 ! NEMO_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005184 name: EMG1_human def: "Probable ribosome biogenesis protein NEP1 gene" [UniProtKB:Q92979] synonym: "C2F" EXACT [UniProtKB:Q92979] xref: EMBL:BC055314 xref: EMBL:U47924 xref: EMBL:U72514 xref: HGNC:HGNC:16912 xref: UniGene:Hs.558447 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006260 ! NEP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005185 name: MME_human def: "Neprilysin gene" [UniProtKB:P08473] synonym: "EPN" EXACT [UniProtKB:P08473] xref: EMBL:BC101632 xref: EMBL:BC101658 xref: EMBL:J03779 xref: EMBL:M26607 xref: EMBL:M26608 xref: EMBL:M26609 xref: EMBL:M26610 xref: EMBL:M26611 xref: EMBL:M26612 xref: EMBL:M26613 xref: EMBL:M26614 xref: EMBL:M26615 xref: EMBL:M26616 xref: EMBL:M26617 xref: EMBL:M26618 xref: EMBL:M26619 xref: EMBL:M26620 xref: EMBL:M26621 xref: EMBL:M26622 xref: EMBL:M26623 xref: EMBL:M26624 xref: EMBL:M26625 xref: EMBL:M26626 xref: EMBL:M26627 xref: EMBL:M26628 xref: EMBL:X07166 xref: EMBL:Y00811 xref: HGNC:HGNC:7154 xref: UniGene:Hs.307734 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005760 ! NEP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005186 name: NF1_human def: "Neurofibromin gene" [UniProtKB:P21359] xref: EMBL:AY796305 xref: EMBL:D10490 xref: EMBL:D12625 xref: EMBL:M38106 xref: EMBL:M38107 xref: EMBL:M38108 xref: EMBL:M38109 xref: EMBL:M38110 xref: EMBL:M38111 xref: EMBL:M38112 xref: EMBL:M38113 xref: EMBL:M38114 xref: EMBL:M38115 xref: EMBL:M38116 xref: EMBL:M60496 xref: EMBL:M60915 xref: EMBL:M61213 xref: EMBL:M82814 xref: EMBL:M89914 xref: EMBL:S51751 xref: EMBL:U17656 xref: EMBL:U17659 xref: EMBL:U17662 xref: EMBL:U17667 xref: EMBL:U17668 xref: EMBL:U17673 xref: EMBL:U17676 xref: EMBL:U17677 xref: EMBL:U17680 xref: EMBL:U17681 xref: EMBL:U17682 xref: EMBL:U17683 xref: EMBL:U17684 xref: EMBL:U17685 xref: EMBL:U17686 xref: EMBL:U17687 xref: EMBL:U17688 xref: EMBL:U17689 xref: EMBL:U17690 xref: EMBL:Y07853 xref: HGNC:HGNC:7765 xref: UniGene:Hs.113577 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001542 ! NF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005188 name: NEFL_human def: "Neurofilament light polypeptide gene" [UniProtKB:P07196] synonym: "NF68" EXACT [UniProtKB:P07196] synonym: "NFL" EXACT [UniProtKB:P07196] xref: EMBL:AY156690 xref: EMBL:BC039237 xref: EMBL:S70309 xref: EMBL:X05608 xref: HGNC:HGNC:7739 xref: UniGene:Hs.521461 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006343 ! NFL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005189 name: NFYA_human def: "Nuclear transcription factor Y subunit alpha gene" [UniProtKB:P23511] xref: EMBL:AL031778 xref: EMBL:BC039244 xref: EMBL:M59079 xref: EMBL:X59711 xref: HGNC:HGNC:7804 xref: UniGene:Hs.10441 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005384 ! NFYA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005190 name: NFYB_human def: "Nuclear transcription factor Y subunit beta gene" [UniProtKB:P25208] synonym: "HAP3" EXACT [UniProtKB:P25208] xref: EMBL:BC005316 xref: EMBL:BC005317 xref: EMBL:BC007035 xref: EMBL:L06145 xref: EMBL:X59710 xref: HGNC:HGNC:7805 xref: UniGene:Hs.84928 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005382 ! NFYB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005193 name: NHP2L1_human def: "NHP2-like protein 1 gene" [UniProtKB:P55769] xref: EMBL:AF091076 xref: EMBL:AF155235 xref: EMBL:BC005358 xref: EMBL:BC019282 xref: EMBL:CR456531 xref: EMBL:D50420 xref: EMBL:Z83840 xref: HGNC:HGNC:7819 xref: UniGene:Hs.182255 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001676 ! NH2L1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005194 name: NIF3L1_human def: "NIF3-like protein 1 gene" [UniProtKB:Q9GZT8] synonym: "ALS2CR1" EXACT [UniProtKB:Q9GZT8] synonym: "MDS015" EXACT [UniProtKB:Q9GZT8] synonym: "My018" EXACT [UniProtKB:Q9GZT8] xref: EMBL:AB038949 xref: EMBL:AF060513 xref: EMBL:AF182416 xref: EMBL:AF283538 xref: EMBL:AK023378 xref: EMBL:BC007654 xref: HGNC:HGNC:13390 xref: UniGene:Hs.145284 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005260 ! NIF3L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005195 name: ZC3HC1_human def: "Nuclear-interacting partner of ALK gene" [UniProtKB:Q86WB0] synonym: "HSPC216" EXACT [UniProtKB:Q86WB0] synonym: "NIPA" EXACT [UniProtKB:Q86WB0] xref: EMBL:AC073320 xref: EMBL:AC087071 xref: EMBL:AF151050 xref: EMBL:AJ537494 xref: EMBL:AK001317 xref: EMBL:AK022373 xref: EMBL:BC011551 xref: EMBL:BC028917 xref: HGNC:HGNC:29913 xref: UniGene:Hs.194157 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001941 ! NIPA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005196 name: NIPBL_human def: "Nipped-B-like protein gene" [UniProtKB:Q6KC79] synonym: "IDN3" EXACT [UniProtKB:Q6KC79] xref: EMBL:AB019494 xref: EMBL:AB019602 xref: EMBL:AJ627032 xref: EMBL:AJ640137 xref: EMBL:AK126804 xref: EMBL:BC033847 xref: EMBL:BX538177 xref: EMBL:BX538178 xref: EMBL:BX640644 xref: HGNC:HGNC:28862 xref: UniGene:Hs.481927 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001908 ! NIPBL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005197 name: NIPSNAP1_human def: "Protein NipSnap homolog 1 gene" [UniProtKB:Q9BPW8] xref: EMBL:AJ001258 xref: EMBL:BC002371 xref: EMBL:BC006473 xref: HGNC:HGNC:7827 xref: UniGene:Hs.173878 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006298 ! NIPS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005198 name: NKRF_human def: "NF-kappa-B-repressing factor gene" [UniProtKB:O15226] synonym: "ITBA4" EXACT [UniProtKB:O15226] synonym: "NRF" EXACT [UniProtKB:O15226] xref: EMBL:AJ011812 xref: EMBL:AY208891 xref: EMBL:BC040379 xref: EMBL:BC047878 xref: EMBL:Y07707 xref: HGNC:HGNC:19374 xref: UniGene:Hs.437084 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006038 ! NKRF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005199 name: NMI_human def: "N-myc-interactor gene" [UniProtKB:Q13287] xref: EMBL:AC009311 xref: EMBL:BC001268 xref: EMBL:U32849 xref: HGNC:HGNC:7854 xref: UniGene:Hs.54483 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005695 ! NMI_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005200 name: SC65_human def: "Synaptonemal complex protein SC65 gene" [UniProtKB:Q92791] synonym: "NOL55" EXACT [UniProtKB:Q92791] xref: EMBL:AJ250583 xref: EMBL:AK222945 xref: EMBL:BC001047 xref: EMBL:BC007942 xref: EMBL:BC011701 xref: EMBL:U47621 xref: UniGene:Hs.446459 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002018 ! SC65_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005201 name: NOC4L_human def: "Nucleolar complex protein 4 homolog gene" [UniProtKB:Q9BVI4] xref: EMBL:AK074489 xref: EMBL:BC001191 xref: EMBL:BC007893 xref: EMBL:BC071958 xref: HGNC:HGNC:28461 xref: UniGene:Hs.558536 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005282 ! NOC4L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005202 name: GTPBP4_human def: "Nucleolar GTP-binding protein 1 gene" [UniProtKB:Q9BZE4] synonym: "CRFG" EXACT [UniProtKB:Q9BZE4] synonym: "NOG1" EXACT [UniProtKB:Q9BZE4] xref: EMBL:AF120334 xref: EMBL:AF325353 xref: EMBL:AK001552 xref: EMBL:BC038975 xref: HGNC:HGNC:21535 xref: UniGene:Hs.215766 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002116 ! NOG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005203 name: NOG_human def: "Noggin precursor gene" [UniProtKB:Q13253] xref: EMBL:BC034027 xref: EMBL:U31202 xref: HGNC:HGNC:7866 xref: UniGene:Hs.248201 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005328 ! NOGG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005204 name: NOL12_human def: "Nucleolar protein 12 gene" [UniProtKB:Q9UGY1] xref: EMBL:AL160132 xref: EMBL:BC002808 xref: EMBL:CR456463 xref: EMBL:Z83844 xref: HGNC:HGNC:28585 xref: UniGene:Hs.632778 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006336 ! NOL12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005206 name: NOLC1_human def: "Nucleolar phosphoprotein p130 gene" [UniProtKB:Q14978] synonym: "KIAA0035" EXACT [UniProtKB:Q14978] xref: EMBL:D21262 xref: EMBL:Z34289 xref: HGNC:HGNC:15608 xref: UniGene:Hs.523238 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001793 ! NOLC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005207 name: NONO_human def: "Non-POU domain-containing octamer-binding protein gene" [UniProtKB:Q15233] synonym: "NRB54" EXACT [UniProtKB:Q15233] xref: EMBL:BC002364 xref: EMBL:BC003129 xref: EMBL:BC012141 xref: EMBL:BC028299 xref: EMBL:BC069616 xref: EMBL:BC069639 xref: EMBL:CR456761 xref: EMBL:L14599 xref: EMBL:U02493 xref: EMBL:U89867 xref: EMBL:Y11289 xref: EMBL:Y11290 xref: EMBL:Y11291 xref: EMBL:Y11292 xref: EMBL:Y11293 xref: EMBL:Y11294 xref: EMBL:Y11295 xref: EMBL:Y11296 xref: EMBL:Y11297 xref: EMBL:Y11298 xref: HGNC:HGNC:7871 xref: UniGene:Hs.533282 xref: UniGene:Hs.700344 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005234 ! NONO_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005208 name: NOTCH1_human def: "Neurogenic locus notch homolog protein 1 precursor gene" [UniProtKB:P46531] synonym: "TAN1" EXACT [UniProtKB:P46531] xref: EMBL:AF308602 xref: EMBL:M73980 xref: HGNC:HGNC:7881 xref: UniGene:Hs.495473 xref: UniGene:Hs.698674 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005974 ! NOTC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005209 name: NOTCH2_human def: "Neurogenic locus notch homolog protein 2 precursor gene" [UniProtKB:Q04721] xref: EMBL:AF308601 xref: EMBL:AF315356 xref: EMBL:U77493 xref: HGNC:HGNC:7882 xref: UniGene:Hs.487360 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001719 ! NOTC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005210 name: NAP1L1_human def: "Nucleosome assembly protein 1-like 1 gene" [UniProtKB:P55209] synonym: "NRP" EXACT [UniProtKB:P55209] xref: EMBL:AL162068 xref: EMBL:BC002387 xref: EMBL:BT007023 xref: EMBL:M86667 xref: HGNC:HGNC:7637 xref: UniGene:Hs.524599 xref: UniGene:Hs.695185 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005376 ! NP1L1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005211 name: NPM2_human def: "Nucleoplasmin-2 gene" [UniProtKB:Q86SE8] xref: EMBL:AY262113 xref: EMBL:AY262114 xref: HGNC:HGNC:7930 xref: UniGene:Hs.131055 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001936 ! NPM2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005212 name: NPM1_human def: "Nucleophosmin gene" [UniProtKB:P06748] synonym: "NPM" EXACT [UniProtKB:P06748] xref: EMBL:AB042278 xref: EMBL:AY347529 xref: EMBL:AY740634 xref: EMBL:AY740635 xref: EMBL:AY740636 xref: EMBL:AY740637 xref: EMBL:AY740638 xref: EMBL:AY740639 xref: EMBL:AY740640 xref: EMBL:BC002398 xref: EMBL:BC008495 xref: EMBL:BC009623 xref: EMBL:BC012566 xref: EMBL:BC014349 xref: EMBL:BC016716 xref: EMBL:BC016768 xref: EMBL:BC016824 xref: EMBL:BC021668 xref: EMBL:BC021983 xref: EMBL:BC050628 xref: EMBL:BC107754 xref: EMBL:BT007011 xref: EMBL:D45915 xref: EMBL:DQ303464 xref: EMBL:J02590 xref: EMBL:M23613 xref: EMBL:M26697 xref: EMBL:M28699 xref: EMBL:M31004 xref: EMBL:U04946 xref: EMBL:U41742 xref: EMBL:U41743 xref: EMBL:U89309 xref: EMBL:U89310 xref: EMBL:U89311 xref: EMBL:U89313 xref: EMBL:U89314 xref: EMBL:U89317 xref: EMBL:U89319 xref: EMBL:U89321 xref: EMBL:X16934 xref: HGNC:HGNC:7910 xref: UniGene:Hs.557550 xref: UniGene:Hs.654469 xref: UniGene:Hs.654583 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001495 ! NPM_HUMAN relationship: codes_for CCO:B0002114 ! Q9BYG9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005213 name: ITGB1BP3_human def: "Nicotinamide riboside kinase 2 gene" [UniProtKB:Q9NPI5] synonym: "NRK2" EXACT [UniProtKB:Q9NPI5] xref: EMBL:AF190819 xref: EMBL:AK001663 xref: EMBL:AK022514 xref: EMBL:AL365377 xref: EMBL:AY611481 xref: EMBL:BC093637 xref: EMBL:BC101575 xref: HGNC:HGNC:17871 xref: UniGene:Hs.135458 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006315 ! NRK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005215 name: NRXN1_human def: "Neurexin-1-alpha precursor gene" [UniProtKB:Q9ULB1] synonym: "KIAA0578" EXACT [UniProtKB:Q9ULB1] xref: EMBL:AB011150 xref: EMBL:AB035356 xref: EMBL:AC007462 xref: EMBL:AC007682 xref: EMBL:AC009234 xref: EMBL:AC068715 xref: EMBL:AC068725 xref: EMBL:AC069550 xref: EMBL:AC078994 xref: HGNC:HGNC:8008 xref: UniGene:Hs.637685 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005545 ! NRX1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005216 name: NSL1_human def: "Kinetochore-associated protein NSL1 homolog gene" [UniProtKB:Q96IY1] synonym: "C1orf48" EXACT [UniProtKB:Q96IY1] synonym: "DC31" EXACT [UniProtKB:Q96IY1] synonym: "DC8" EXACT [UniProtKB:Q96IY1] xref: EMBL:AC104333 xref: EMBL:AF201941 xref: EMBL:AF255793 xref: EMBL:AL050084 xref: EMBL:AL591647 xref: EMBL:BC007067 xref: HGNC:HGNC:24548 xref: UniGene:Hs.497692 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002043 ! NSL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005217 name: SMPD3_human def: "Sphingomyelin phosphodiesterase 3 gene" [UniProtKB:Q9NY59] xref: EMBL:AJ250460 xref: EMBL:BC112238 xref: HGNC:HGNC:14240 xref: UniGene:Hs.368421 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002175 ! NSMA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005218 name: NUTF2_human def: "Nuclear transport factor 2 gene" [UniProtKB:P61970] synonym: "NTF2" EXACT [UniProtKB:P61970] xref: EMBL:BC002348 xref: EMBL:CR456937 xref: EMBL:U43939 xref: EMBL:X07315 xref: HGNC:HGNC:13722 xref: UniGene:Hs.696342 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006067 ! NTF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005219 name: NUAK2_human def: "NUAK family SNF1-like kinase 2 gene" [UniProtKB:Q9H093] synonym: "SNARK" EXACT [UniProtKB:Q9H093] xref: EMBL:AK074830 xref: EMBL:AL136891 xref: EMBL:BC017306 xref: HGNC:HGNC:29558 xref: UniGene:Hs.497512 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005874 ! NUAK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005220 name: NCL_human def: "Nucleolin gene" [UniProtKB:P19338] xref: EMBL:AC017104 xref: EMBL:AK091742 xref: EMBL:M60858 xref: HGNC:HGNC:7667 xref: UniGene:Hs.79110 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005733 ! NUCL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005221 name: NUDT10_human def: "Diphosphoinositol polyphosphate phosphohydrolase 3 alpha gene" [UniProtKB:Q8NFP7] synonym: "APS2" EXACT [UniProtKB:Q8NFP7] synonym: "DIPP3A" EXACT [UniProtKB:Q8NFP7] xref: EMBL:AF469196 xref: EMBL:AL158055 xref: EMBL:BC049383 xref: EMBL:BC050700 xref: HGNC:HGNC:17621 xref: UniGene:Hs.375178 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006344 ! NUD10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005222 name: NUDCD3_human def: "NudC domain-containing protein 3 gene" [UniProtKB:Q8IVD9] synonym: "KIAA1068" EXACT [UniProtKB:Q8IVD9] xref: EMBL:AB028991 xref: EMBL:AC004453 xref: EMBL:AK024226 xref: EMBL:BC003691 xref: EMBL:BC011673 xref: EMBL:BC035014 xref: HGNC:HGNC:22208 xref: UniGene:Hs.488171 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005198 ! NUDC3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005223 name: NUDC_human def: "Nuclear migration protein nudC gene" [UniProtKB:Q9Y266] xref: EMBL:AB019408 xref: EMBL:AF086922 xref: EMBL:AF100760 xref: EMBL:AF125465 xref: EMBL:AF130736 xref: EMBL:AL136725 xref: EMBL:AL356390 xref: EMBL:BC002399 xref: EMBL:BC003132 xref: EMBL:BC006147 xref: EMBL:BC007280 xref: EMBL:BC015153 xref: EMBL:BC021139 xref: HGNC:HGNC:8045 xref: UniGene:Hs.263812 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002250 ! NUDC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005224 name: NUF2_human def: "Kinetochore protein Nuf2 gene" [UniProtKB:Q9BZD4] synonym: "CDCA1" EXACT [UniProtKB:Q9BZD4] synonym: "NUF2R" EXACT [UniProtKB:Q9BZD4] xref: EMBL:AB050577 xref: EMBL:AB050578 xref: EMBL:AF326731 xref: EMBL:AK093348 xref: EMBL:AL592435 xref: EMBL:BC008489 xref: EMBL:BC021171 xref: HGNC:HGNC:14621 xref: UniGene:Hs.651950 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002115 ! NUF2_HUMAN relationship: codes_for CCO:B0041237 ! B1AQT3_HUMAN relationship: codes_for CCO:B0041238 ! B1AQT4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005225 name: NUMA1_human def: "Nuclear mitotic apparatus protein 1 gene" [UniProtKB:Q14980] synonym: "NUMA" EXACT [UniProtKB:Q14980] xref: EMBL:Z11583 xref: EMBL:Z11584 xref: HGNC:HGNC:8059 xref: UniGene:Hs.325978 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001794 ! NUMA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005226 name: NUSAP1_human def: "Nucleolar and spindle-associated protein 1 gene" [UniProtKB:Q9BXS6] synonym: "ANKT" EXACT [UniProtKB:Q9BXS6] synonym: "BM-037" EXACT [UniProtKB:Q9BXS6] synonym: "PRO0310" EXACT [UniProtKB:Q9BXS6] xref: EMBL:AF090915 xref: EMBL:AF217513 xref: EMBL:AF290612 xref: EMBL:AF305711 xref: EMBL:AK023483 xref: EMBL:AK222819 xref: EMBL:BC001308 xref: EMBL:BC010838 xref: EMBL:BC012887 xref: EMBL:BC024772 xref: EMBL:CH471125 xref: HGNC:HGNC:18538 xref: UniGene:Hs.615092 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002108 ! NUSAP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005228 name: OBSCN_human def: "Obscurin gene" [UniProtKB:Q5VST9] synonym: "KIAA1556" EXACT [UniProtKB:Q5VST9] synonym: "KIAA1639" EXACT [UniProtKB:Q5VST9] xref: EMBL:AB046776 xref: EMBL:AB046859 xref: EMBL:AJ002535 xref: EMBL:AJ314896 xref: EMBL:AJ314898 xref: EMBL:AJ314900 xref: EMBL:AJ314901 xref: EMBL:AJ314903 xref: EMBL:AJ314904 xref: EMBL:AJ314905 xref: EMBL:AJ314906 xref: EMBL:AJ314907 xref: EMBL:AJ314908 xref: EMBL:AK097489 xref: EMBL:AL353593 xref: EMBL:AL359510 xref: EMBL:AL670729 xref: EMBL:AM231061 xref: EMBL:BC043916 xref: HGNC:HGNC:15719 xref: UniGene:Hs.650039 xref: UniGene:Hs.656999 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005645 ! OBSCN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005230 name: OGT_human def: "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit gene" [UniProtKB:O15294] xref: EMBL:AJ315767 xref: EMBL:AL050366 xref: EMBL:AL833085 xref: EMBL:BC014434 xref: EMBL:BC038180 xref: EMBL:BX537844 xref: EMBL:U77413 xref: HGNC:HGNC:8127 xref: UniGene:Hs.405410 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005806 ! OGT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005231 name: OLA1_human def: "Obg-like ATPase 1 gene" [UniProtKB:Q9NTK5] synonym: "GTPBP9" EXACT [UniProtKB:Q9NTK5] synonym: "PRO2455" EXACT [UniProtKB:Q9NTK5] synonym: "PTD004" EXACT [UniProtKB:Q9NTK5] xref: EMBL:AF078859 xref: EMBL:AF078868 xref: EMBL:AF116703 xref: EMBL:AF134478 xref: EMBL:AK027523 xref: EMBL:AK074710 xref: EMBL:AL136546 xref: EMBL:BC012842 xref: EMBL:BC013925 xref: EMBL:BC029376 xref: EMBL:BC091522 xref: HGNC:HGNC:28833 xref: UniGene:Hs.157351 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006040 ! OLA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005232 name: ORC1L_human def: "Origin recognition complex subunit 1 gene" [UniProtKB:Q13415] synonym: "ORC1" EXACT [UniProtKB:Q13415] synonym: "PARC1" EXACT [UniProtKB:Q13415] xref: EMBL:AL513218 xref: EMBL:U40152 xref: EMBL:U43416 xref: HGNC:HGNC:8487 xref: UniGene:Hs.17908 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005352 ! ORC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005233 name: ORC2L_human def: "Origin recognition complex subunit 2 gene" [UniProtKB:Q13416] synonym: "ORC2" EXACT [UniProtKB:Q13416] xref: EMBL:AY652588 xref: EMBL:BC014834 xref: EMBL:U27459 xref: EMBL:U40268 xref: HGNC:HGNC:8488 xref: UniGene:Hs.444870 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005353 ! ORC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005234 name: ORC3L_human def: "Origin recognition complex subunit 3 gene" [UniProtKB:Q9UBD5] synonym: "LATHEO" EXACT [UniProtKB:Q9UBD5] xref: EMBL:AF093535 xref: EMBL:AF125507 xref: EMBL:AF135044 xref: EMBL:AK222795 xref: EMBL:AL080116 xref: EMBL:AL133211 xref: EMBL:AL451126 xref: EMBL:AY623113 xref: EMBL:BC035494 xref: EMBL:BC047689 xref: EMBL:U50950 xref: HGNC:HGNC:8489 xref: UniGene:Hs.410228 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005392 ! ORC3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005235 name: ORC4L_human def: "Origin recognition complex subunit 4 gene" [UniProtKB:O43929] xref: EMBL:AF022108 xref: EMBL:AF047598 xref: EMBL:AF132596 xref: EMBL:AY600302 xref: EMBL:BC014847 xref: HGNC:HGNC:8490 xref: UniGene:Hs.558364 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005389 ! ORC4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005236 name: ORC5L_human def: "Origin recognition complex subunit 5 gene" [UniProtKB:O43913] xref: EMBL:AF047599 xref: EMBL:AF049127 xref: EMBL:BC023652 xref: EMBL:U92538 xref: HGNC:HGNC:8491 xref: UniGene:Hs.432948 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005390 ! ORC5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005237 name: ORC6L_human def: "Origin recognition complex subunit 6 gene" [UniProtKB:Q9Y5N6] xref: EMBL:AF139658 xref: EMBL:BC039032 xref: EMBL:BC063565 xref: HGNC:HGNC:17151 xref: UniGene:Hs.49760 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005388 ! ORC6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005238 name: OSBPL1A_human def: "Oxysterol-binding protein-related protein 1 gene" [UniProtKB:Q9BXW6] synonym: "ORP1" EXACT [UniProtKB:Q9BXW6] synonym: "OSBP8" EXACT [UniProtKB:Q9BXW6] synonym: "OSBPL1" EXACT [UniProtKB:Q9BXW6] synonym: "OSBPL1B" EXACT [UniProtKB:Q9BXW6] xref: EMBL:AF274714 xref: EMBL:AF323726 xref: EMBL:AF392449 xref: EMBL:AF392450 xref: EMBL:AK001079 xref: HGNC:HGNC:16398 xref: UniGene:Hs.370725 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006009 ! OSBL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005239 name: OSGIN2_human def: "Oxidative stress-induced growth inhibitor 2 gene" [UniProtKB:Q9Y236] synonym: "C8orf1" EXACT [UniProtKB:Q9Y236] xref: EMBL:AF061326 xref: EMBL:AF069291 xref: EMBL:BC031054 xref: HGNC:HGNC:1355 xref: UniGene:Hs.436445 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002246 ! OSGI2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005241 name: PPP2R3B_human def: "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta gene" [UniProtKB:Q9Y5P8] synonym: "PPP2R3L" EXACT [UniProtKB:Q9Y5P8] xref: EMBL:AF135016 xref: EMBL:BC063429 xref: EMBL:BK000521 xref: HGNC:HGNC:13417 xref: UniGene:Hs.124942 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002258 ! P2R3B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005242 name: GPR23_human def: "Lysophosphatidic acid receptor 4 gene" [UniProtKB:Q99677] synonym: "LPA4" EXACT [UniProtKB:Q99677] synonym: "P2RY9" EXACT [UniProtKB:Q99677] xref: EMBL:AF005419 xref: EMBL:AL590083 xref: EMBL:AY301274 xref: EMBL:BC069996 xref: EMBL:BC074722 xref: EMBL:BC095538 xref: EMBL:U66578 xref: EMBL:U90322 xref: EMBL:U90323 xref: HGNC:HGNC:4478 xref: UniGene:Hs.522701 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006045 ! P2RY9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005243 name: PIK3C2A_human def: "Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide gene" [UniProtKB:O00443] xref: EMBL:BC113658 xref: EMBL:Y13367 xref: HGNC:HGNC:8971 xref: UniGene:Hs.175343 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006071 ! P3C2A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005244 name: PIK3C2B_human def: "Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide gene" [UniProtKB:O00750] xref: EMBL:AL606489 xref: EMBL:Y11312 xref: EMBL:Y13892 xref: HGNC:HGNC:8972 xref: UniGene:Hs.497487 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005711 ! P3C2B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005245 name: TP53_human def: "Cellular tumor antigen p53 gene" [UniProtKB:P04637] synonym: "P53" EXACT [UniProtKB:P04637] xref: EMBL:AB082923 xref: EMBL:AF135120 xref: EMBL:AF135121 xref: EMBL:AF136270 xref: EMBL:AF136271 xref: EMBL:AF209128 xref: EMBL:AF209129 xref: EMBL:AF209130 xref: EMBL:AF209131 xref: EMBL:AF209132 xref: EMBL:AF209133 xref: EMBL:AF209134 xref: EMBL:AF209135 xref: EMBL:AF209136 xref: EMBL:AF209148 xref: EMBL:AF209149 xref: EMBL:AF209150 xref: EMBL:AF209151 xref: EMBL:AF209152 xref: EMBL:AF209153 xref: EMBL:AF209154 xref: EMBL:AF209155 xref: EMBL:AF209156 xref: EMBL:AF210308 xref: EMBL:AF210309 xref: EMBL:AF210310 xref: EMBL:AF240684 xref: EMBL:AF240685 xref: EMBL:AF307851 xref: EMBL:AM076971 xref: EMBL:AY270155 xref: EMBL:AY359814 xref: EMBL:AY390341 xref: EMBL:AY429684 xref: EMBL:AY838896 xref: EMBL:BC003596 xref: EMBL:DQ186648 xref: EMBL:EF101869 xref: EMBL:K03199 xref: EMBL:M13112 xref: EMBL:M13113 xref: EMBL:M13114 xref: EMBL:M13115 xref: EMBL:M13116 xref: EMBL:M13117 xref: EMBL:M13118 xref: EMBL:M13119 xref: EMBL:M13120 xref: EMBL:M13121 xref: EMBL:M14694 xref: EMBL:M14695 xref: EMBL:M22882 xref: EMBL:M22883 xref: EMBL:M22884 xref: EMBL:M22887 xref: EMBL:M22888 xref: EMBL:M22894 xref: EMBL:M22895 xref: EMBL:M22896 xref: EMBL:M22897 xref: EMBL:M22898 xref: EMBL:U63714 xref: EMBL:U94788 xref: EMBL:X01405 xref: EMBL:X02469 xref: EMBL:X54156 xref: EMBL:X60011 xref: EMBL:X60012 xref: EMBL:X60013 xref: EMBL:X60014 xref: EMBL:X60015 xref: EMBL:X60016 xref: EMBL:X60017 xref: EMBL:X60018 xref: EMBL:X60019 xref: EMBL:X60020 xref: HGNC:HGNC:11998 xref: UniGene:Hs.654481 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001483 ! P53_HUMAN relationship: codes_for CCO:B0001831 ! Q3LRW5_HUMAN relationship: codes_for CCO:B0022308 ! Q1MSW9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005246 name: GATAD2A_human def: "Transcriptional repressor p66-alpha gene" [UniProtKB:Q86YP4] xref: EMBL:AK000092 xref: EMBL:AL390164 xref: EMBL:AY186731 xref: EMBL:BC011684 xref: EMBL:BC012902 xref: HGNC:HGNC:29989 xref: UniGene:Hs.696033 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005907 ! P66A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005247 name: GATAD2B_human def: "Transcriptional repressor p66-beta gene" [UniProtKB:Q8WXI9] synonym: "KIAA1150" EXACT [UniProtKB:Q8WXI9] xref: EMBL:AB032976 xref: EMBL:AF411836 xref: EMBL:AL513523 xref: EMBL:BC069419 xref: EMBL:BC112052 xref: EMBL:BC112080 xref: HGNC:HGNC:30778 xref: UniGene:Hs.4779 xref: UniGene:Hs.596854 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005908 ! P66B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005248 name: TP73_human def: "Tumor protein p73 gene" [UniProtKB:O15350] synonym: "P73" EXACT [UniProtKB:O15350] xref: EMBL:AB055065 xref: EMBL:AB055066 xref: EMBL:AF077616 xref: EMBL:AF077617 xref: EMBL:AF077618 xref: EMBL:AF077619 xref: EMBL:AF077620 xref: EMBL:AF077621 xref: EMBL:AF077624 xref: EMBL:AF077625 xref: EMBL:AF077626 xref: EMBL:AF077627 xref: EMBL:AF077628 xref: EMBL:AF079082 xref: EMBL:AF079083 xref: EMBL:AF079084 xref: EMBL:AF079085 xref: EMBL:AF079086 xref: EMBL:AF079087 xref: EMBL:AF079088 xref: EMBL:AF079089 xref: EMBL:AF079090 xref: EMBL:AF079091 xref: EMBL:AF079092 xref: EMBL:AF079093 xref: EMBL:AF079094 xref: EMBL:AL136528 xref: EMBL:AY040827 xref: EMBL:AY040828 xref: EMBL:AY040829 xref: EMBL:BC117251 xref: EMBL:BC117253 xref: EMBL:Y11416 xref: HGNC:HGNC:12003 xref: UniGene:Hs.697294 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001374 ! P73_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005249 name: COIL_human def: "Coilin gene" [UniProtKB:P38432] synonym: "CLN80" EXACT [UniProtKB:P38432] xref: EMBL:BC010385 xref: EMBL:M58411 xref: EMBL:U06632 xref: HGNC:HGNC:2184 xref: UniGene:Hs.532795 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005621 ! P80C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005250 name: PAFAH1B2_human def: "Platelet-activating factor acetylhydrolase IB subunit beta gene" [UniProtKB:P68402] synonym: "PAFAHB" EXACT [UniProtKB:P68402] xref: EMBL:BC000398 xref: EMBL:BC019301 xref: EMBL:D63390 xref: HGNC:HGNC:8575 xref: UniGene:Hs.696131 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006291 ! PA1B2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005251 name: PAFAH1B3_human def: "Platelet-activating factor acetylhydrolase IB subunit gamma gene" [UniProtKB:Q15102] synonym: "PAFAHG" EXACT [UniProtKB:Q15102] xref: EMBL:AC006486 xref: EMBL:BC003016 xref: EMBL:BC007863 xref: EMBL:D63391 xref: HGNC:HGNC:8576 xref: UniGene:Hs.466831 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006098 ! PA1B3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005252 name: PA2G4_human def: "Proliferation-associated protein 2G4 gene" [UniProtKB:Q9UQ80] synonym: "EBP1" EXACT [UniProtKB:Q9UQ80] xref: EMBL:AF104668 xref: EMBL:AF104669 xref: EMBL:AF104670 xref: EMBL:BC001951 xref: EMBL:BC007561 xref: EMBL:BC069786 xref: EMBL:U59435 xref: EMBL:U87954 xref: HGNC:HGNC:8550 xref: UniGene:Hs.524498 xref: UniGene:Hs.573018 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002239 ! PA2G4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005253 name: PABPC1_human def: "Polyadenylate-binding protein 1 gene" [UniProtKB:P11940] synonym: "PAB1" EXACT [UniProtKB:P11940] synonym: "PABP1" EXACT [UniProtKB:P11940] synonym: "PABPC2" EXACT [UniProtKB:P11940] xref: EMBL:BC015958 xref: EMBL:BC023520 xref: EMBL:BC041863 xref: EMBL:U68093 xref: EMBL:U68094 xref: EMBL:U68095 xref: EMBL:U68097 xref: EMBL:U68098 xref: EMBL:U68099 xref: EMBL:U68100 xref: EMBL:U68101 xref: EMBL:U68102 xref: EMBL:U68103 xref: EMBL:U68104 xref: EMBL:Y00345 xref: EMBL:Z48501 xref: HGNC:HGNC:8554 xref: UniGene:Hs.387804 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005854 ! PABP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005255 name: PAEP_human def: "Glycodelin precursor gene" [UniProtKB:P09466] xref: EMBL:AL050169 xref: EMBL:AL354761 xref: EMBL:BC069451 xref: EMBL:BC069562 xref: EMBL:BC112304 xref: EMBL:BC113728 xref: EMBL:J04129 xref: EMBL:M34046 xref: EMBL:M61886 xref: HGNC:HGNC:8573 xref: UniGene:Hs.532325 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006212 ! PAEP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005256 name: PAK1_human def: "Serine/threonine-protein kinase PAK 1 gene" [UniProtKB:Q13153] xref: EMBL:AF071884 xref: EMBL:BC109299 xref: EMBL:U24152 xref: EMBL:U51120 xref: HGNC:HGNC:8590 xref: UniGene:Hs.435714 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005469 ! PAK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005257 name: PANX3_human def: "Pannexin-3 gene" [UniProtKB:Q96QZ0] xref: EMBL:AF406650 xref: HGNC:HGNC:20573 xref: UniGene:Hs.99235 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006029 ! PANX3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005258 name: PAPD5_human def: "PAP-associated domain-containing protein 5 gene" [UniProtKB:Q8NDF8] xref: EMBL:AF089897 xref: EMBL:AK001141 xref: EMBL:AK097589 xref: EMBL:AL833922 xref: HGNC:HGNC:30758 xref: UniGene:Hs.514342 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001975 ! PAPD5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005259 name: PARP12_human def: "Poly [ADP-ribose] polymerase 12 gene" [UniProtKB:Q9H0J9] synonym: "ZC3HDC1" EXACT [UniProtKB:Q9H0J9] xref: EMBL:AC004849 xref: EMBL:AC004961 xref: EMBL:AC025816 xref: EMBL:AK026346 xref: EMBL:AL136766 xref: EMBL:AL137255 xref: EMBL:BC081541 xref: HGNC:HGNC:21919 xref: UniGene:Hs.12646 xref: UniGene:Hs.308710 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006037 ! PAR12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005261 name: PARD3B_human def: "Partitioning-defective 3 homolog B gene" [UniProtKB:Q8TEW8] synonym: "ALS2CR19" EXACT [UniProtKB:Q8TEW8] synonym: "PAR3B" EXACT [UniProtKB:Q8TEW8] synonym: "PAR3L" EXACT [UniProtKB:Q8TEW8] xref: EMBL:AB053321 xref: EMBL:AB073472 xref: EMBL:AB092439 xref: EMBL:AF428250 xref: EMBL:AF428251 xref: EMBL:AF466152 xref: EMBL:AK056157 xref: EMBL:AK057965 xref: HGNC:HGNC:14446 xref: UniGene:Hs.657382 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001997 ! PAR3L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005262 name: PARD6A_human def: "Partitioning defective 6 homolog alpha gene" [UniProtKB:Q9NPB6] synonym: "PAR6A" EXACT [UniProtKB:Q9NPB6] xref: EMBL:AB041642 xref: EMBL:AB043634 xref: EMBL:AF028827 xref: EMBL:AF252292 xref: EMBL:AF265565 xref: EMBL:AJ277095 xref: EMBL:BC015626 xref: HGNC:HGNC:15943 xref: UniGene:Hs.112933 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002150 ! PAR6A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005263 name: PARD6B_human def: "Partitioning defective 6 homolog beta gene" [UniProtKB:Q9BYG5] synonym: "PAR6B" EXACT [UniProtKB:Q9BYG5] xref: EMBL:AB044555 xref: EMBL:AL031680 xref: EMBL:BC060847 xref: HGNC:HGNC:16245 xref: UniGene:Hs.589848 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002113 ! PAR6B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005264 name: PARD6G_human def: "Partitioning defective 6 homolog gamma gene" [UniProtKB:Q9BYG4] synonym: "PAR6G" EXACT [UniProtKB:Q9BYG4] xref: EMBL:AB044556 xref: EMBL:BC060797 xref: HGNC:HGNC:16076 xref: UniGene:Hs.654920 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002112 ! PAR6G_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005265 name: PARC_human def: "p53-associated parkin-like cytoplasmic protein gene" [UniProtKB:Q8IWT3] synonym: "H7AP1" EXACT [UniProtKB:Q8IWT3] synonym: "KIAA0708" EXACT [UniProtKB:Q8IWT3] xref: EMBL:AB014608 xref: EMBL:AJ318215 xref: EMBL:AK125228 xref: EMBL:AK129649 xref: EMBL:AY145132 xref: EMBL:BC002879 xref: EMBL:CR749511 xref: EMBL:CR749841 xref: UniGene:Hs.485434 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001949 ! PARC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005266 name: PARD3_human def: "Partitioning-defective 3 homolog gene" [UniProtKB:Q8TEW0] synonym: "PAR3" EXACT [UniProtKB:Q8TEW0] synonym: "PAR3A" EXACT [UniProtKB:Q8TEW0] xref: EMBL:AB073671 xref: EMBL:AF177228 xref: EMBL:AF196185 xref: EMBL:AF196186 xref: EMBL:AF252293 xref: EMBL:AF332592 xref: EMBL:AF332593 xref: EMBL:AF467002 xref: EMBL:AF467003 xref: EMBL:AF467004 xref: EMBL:AF467005 xref: EMBL:AF467006 xref: EMBL:AK000761 xref: EMBL:AK027735 xref: EMBL:BC011711 xref: HGNC:HGNC:16051 xref: UniGene:Hs.131489 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001996 ! PARD3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005267 name: PARK7_human def: "Protein DJ-1 gene" [UniProtKB:Q99497] xref: EMBL:AB045294 xref: EMBL:AB073864 xref: EMBL:AF021819 xref: EMBL:AL034417 xref: EMBL:AY648999 xref: EMBL:BC008188 xref: EMBL:D61380 xref: HGNC:HGNC:16369 xref: UniGene:Hs.419640 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005443 ! PARK7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005268 name: PARN_human def: "Poly(A)-specific ribonuclease PARN gene" [UniProtKB:O95453] synonym: "DAN" EXACT [UniProtKB:O95453] xref: EMBL:AJ005698 xref: EMBL:BC050029 xref: HGNC:HGNC:8609 xref: UniGene:Hs.253197 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005347 ! PARN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005271 name: PXN_human def: "Paxillin gene" [UniProtKB:P49023] xref: EMBL:AC004263 xref: EMBL:D86862 xref: EMBL:D86863 xref: EMBL:U14588 xref: EMBL:U87941 xref: EMBL:U87942 xref: EMBL:U87943 xref: EMBL:U87944 xref: EMBL:U87945 xref: EMBL:U87946 xref: HGNC:HGNC:9718 xref: UniGene:Hs.446336 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005837 ! PAXI_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005272 name: PBRM1_human def: "Protein polybromo-1 gene" [UniProtKB:Q86U86] synonym: "PB1" EXACT [UniProtKB:Q86U86] xref: EMBL:AF177387 xref: EMBL:AF197569 xref: EMBL:AF225870 xref: EMBL:AF225871 xref: EMBL:AF225872 xref: EMBL:AY281068 xref: HGNC:HGNC:30064 xref: UniGene:Hs.189920 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001938 ! PB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005273 name: PBX2_human def: "Pre-B-cell leukemia transcription factor 2 gene" [UniProtKB:P40425] synonym: "G17" EXACT [UniProtKB:P40425] xref: EMBL:AL662830 xref: EMBL:AL662884 xref: EMBL:AL845464 xref: EMBL:BC082261 xref: EMBL:D28769 xref: EMBL:U89336 xref: EMBL:X59842 xref: EMBL:X80700 xref: HGNC:HGNC:8633 xref: UniGene:Hs.509545 xref: UniGene:Hs.534342 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005895 ! PBX2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005274 name: PCAF_human def: "Histone acetyltransferase PCAF gene" [UniProtKB:Q92831] xref: EMBL:BC060823 xref: EMBL:BC070075 xref: EMBL:U57317 xref: HGNC:HGNC:8638 xref: UniGene:Hs.533055 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002019 ! PCAF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005275 name: PCDHA4_human def: "Protocadherin alpha-4 precursor gene" [UniProtKB:Q9UN74] xref: EMBL:AC005609 xref: EMBL:AF152312 xref: EMBL:AF152482 xref: HGNC:HGNC:8670 xref: UniGene:Hs.199343 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006099 ! PCDA4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005276 name: PCDH9_human def: "Protocadherin-9 precursor gene" [UniProtKB:Q9HC56] xref: EMBL:AF169692 xref: EMBL:AL136999 xref: EMBL:AL355173 xref: EMBL:AL603863 xref: HGNC:HGNC:8661 xref: UniGene:Hs.654709 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006022 ! PCDH9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005278 name: PCNA_human def: "Proliferating cell nuclear antigen gene" [UniProtKB:P12004] xref: EMBL:AF527838 xref: EMBL:AL121924 xref: EMBL:BC000491 xref: EMBL:BC062439 xref: EMBL:J04718 xref: EMBL:M15796 xref: HGNC:HGNC:8729 xref: UniGene:Hs.147433 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001513 ! PCNA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005279 name: PCNP_human def: "PEST proteolytic signal-containing nuclear protein gene" [UniProtKB:Q8WW12] xref: EMBL:AB037675 xref: EMBL:BC013916 xref: EMBL:BC022001 xref: EMBL:CR627371 xref: HGNC:HGNC:30023 xref: UniGene:Hs.654949 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002005 ! PCNP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005280 name: PCNT_human def: "Pericentrin gene" [UniProtKB:O95613] synonym: "KIAA0402" EXACT [UniProtKB:O95613] synonym: "PCNT2" EXACT [UniProtKB:O95613] xref: EMBL:AB007862 xref: EMBL:AF515282 xref: EMBL:AK093923 xref: EMBL:U52962 xref: HGNC:HGNC:16068 xref: UniGene:Hs.474069 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006078 ! PCNT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005283 name: PCTK3_human def: "Serine/threonine-protein kinase PCTAIRE-3 gene" [UniProtKB:Q07002] xref: EMBL:AL357131 xref: EMBL:BC011526 xref: EMBL:BT007299 xref: EMBL:X66362 xref: HGNC:HGNC:8751 xref: UniGene:Hs.445402 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005295 ! PCTK3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005284 name: PDCD4_human def: "Programmed cell death protein 4 gene" [UniProtKB:Q53EL6] synonym: "H731" EXACT [UniProtKB:Q53EL6] xref: EMBL:AK223623 xref: EMBL:AL136368 xref: EMBL:AL158163 xref: EMBL:BC015036 xref: EMBL:BC026104 xref: EMBL:BC031049 xref: EMBL:U83908 xref: EMBL:U96628 xref: HGNC:HGNC:8763 xref: UniGene:Hs.232543 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001836 ! PDCD4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005285 name: PDCD5_human def: "Programmed cell death protein 5 gene" [UniProtKB:O14737] synonym: "TFAR19" EXACT [UniProtKB:O14737] xref: EMBL:AF014955 xref: EMBL:BC015519 xref: EMBL:BT006694 xref: EMBL:CR456934 xref: HGNC:HGNC:8764 xref: UniGene:Hs.443831 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006152 ! PDCD5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005286 name: PDE6D_human def: "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta gene" [UniProtKB:O43924] synonym: "PDED" EXACT [UniProtKB:O43924] xref: EMBL:AF022912 xref: EMBL:AF042833 xref: EMBL:AF042834 xref: EMBL:AF042835 xref: EMBL:AF045999 xref: EMBL:AJ001626 xref: EMBL:BC007831 xref: EMBL:BT007278 xref: HGNC:HGNC:8788 xref: UniGene:Hs.516808 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006130 ! PDE6D_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005292 name: PDLIM5_human def: "PDZ and LIM domain protein 5 gene" [UniProtKB:Q96HC4] synonym: "ENH" EXACT [UniProtKB:Q96HC4] xref: EMBL:AF061258 xref: EMBL:BC008741 xref: EMBL:BT007328 xref: HGNC:HGNC:17468 xref: UniGene:Hs.480311 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005976 ! PDLI5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005293 name: PDLIM7_human def: "PDZ and LIM domain protein 7 gene" [UniProtKB:Q9NR12] synonym: "ENIGMA" EXACT [UniProtKB:Q9NR12] xref: EMBL:AF265209 xref: EMBL:AF345904 xref: EMBL:AF345905 xref: EMBL:AF345906 xref: EMBL:BC001093 xref: EMBL:BC014521 xref: EMBL:BC067806 xref: EMBL:BC084575 xref: EMBL:L35240 xref: HGNC:HGNC:22958 xref: UniGene:Hs.533040 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005224 ! PDLI7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005294 name: PDPK1_human def: "3-phosphoinositide-dependent protein kinase 1 gene" [UniProtKB:O15530] synonym: "PDK1" EXACT [UniProtKB:O15530] xref: EMBL:AF017995 xref: EMBL:BC012103 xref: EMBL:Y15056 xref: HGNC:HGNC:8816 xref: UniGene:Hs.459691 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006233 ! PDPK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005295 name: PDS5A_human def: "Sister chromatid cohesion protein PDS5 homolog A gene" [UniProtKB:Q29RF7] synonym: "KIAA0648" EXACT [UniProtKB:Q29RF7] synonym: "PDS5" EXACT [UniProtKB:Q29RF7] synonym: "PIG54" EXACT [UniProtKB:Q29RF7] xref: EMBL:AB014548 xref: EMBL:AF294791 xref: EMBL:AK098331 xref: EMBL:AY550968 xref: EMBL:BC041361 xref: EMBL:BC114218 xref: EMBL:BC126225 xref: EMBL:CR749425 xref: HGNC:HGNC:29088 xref: UniGene:Hs.331431 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001829 ! PDS5A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005296 name: PDZD4_human def: "PDZ domain-containing protein 4 gene" [UniProtKB:Q76G19] synonym: "KIAA1444" EXACT [UniProtKB:Q76G19] synonym: "PDZK4" EXACT [UniProtKB:Q76G19] synonym: "PDZRN4L" EXACT [UniProtKB:Q76G19] xref: EMBL:AB040877 xref: EMBL:AB103478 xref: EMBL:AK091444 xref: EMBL:BC002606 xref: EMBL:BC080584 xref: HGNC:HGNC:21167 xref: UniGene:Hs.92732 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005977 ! PDZD4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005297 name: PEF1_human def: "Peflin gene" [UniProtKB:Q9UBV8] synonym: "ABP32" EXACT [UniProtKB:Q9UBV8] synonym: "UNQ1845/PRO3573" EXACT [UniProtKB:Q9UBV8] xref: EMBL:AB018357 xref: EMBL:AB026628 xref: EMBL:AK001420 xref: EMBL:AY359011 xref: EMBL:BC002773 xref: EMBL:BC012561 xref: EMBL:CR542139 xref: HGNC:HGNC:30009 xref: UniGene:Hs.470417 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006326 ! PEF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005299 name: PEX19_human def: "Peroxisomal biogenesis factor 19 gene" [UniProtKB:P40855] synonym: "HK33" EXACT [UniProtKB:P40855] synonym: "OK/SW-cl.22" EXACT [UniProtKB:P40855] synonym: "PXF" EXACT [UniProtKB:P40855] xref: EMBL:AB018541 xref: EMBL:AB062286 xref: EMBL:BC000496 xref: EMBL:BT006879 xref: EMBL:X75535 xref: EMBL:Y09048 xref: HGNC:HGNC:9713 xref: UniGene:Hs.517232 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005820 ! PEX19_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005300 name: PEX26_human def: "Peroxisome assembly protein 26 gene" [UniProtKB:Q7Z412] xref: EMBL:AB089678 xref: EMBL:AB103106 xref: EMBL:AB103107 xref: EMBL:AB103108 xref: EMBL:AB103109 xref: EMBL:AB103110 xref: EMBL:AC016027 xref: EMBL:AK000065 xref: EMBL:AK000702 xref: EMBL:BC016280 xref: EMBL:BC047320 xref: EMBL:CR456362 xref: HGNC:HGNC:22965 xref: UniGene:Hs.517400 xref: UniGene:Hs.648441 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005312 ! PEX26_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005301 name: PFDN1_human def: "Prefoldin subunit 1 gene" [UniProtKB:O60925] synonym: "PFD1" EXACT [UniProtKB:O60925] xref: EMBL:AK223394 xref: EMBL:BC003620 xref: EMBL:BC006202 xref: EMBL:BC011869 xref: EMBL:Y17392 xref: HGNC:HGNC:8866 xref: UniGene:Hs.483564 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001420 ! PFD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005302 name: PGAM1_human def: "Phosphoglycerate mutase 1 gene" [UniProtKB:P18669] synonym: "CDABP0006" EXACT [UniProtKB:P18669] synonym: "PGAMA" EXACT [UniProtKB:P18669] xref: EMBL:AY007118 xref: EMBL:BC010038 xref: EMBL:BC011678 xref: EMBL:BC053356 xref: EMBL:BC066959 xref: EMBL:BC073742 xref: EMBL:J04173 xref: HGNC:HGNC:8888 xref: UniGene:Hs.592599 xref: UniGene:Hs.632918 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006323 ! PGAM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005303 name: HSPG2_human def: "Basement membrane-specific heparan sulfate proteoglycan core protein precursor gene" [UniProtKB:P98160] xref: EMBL:AL445795 xref: EMBL:L22078 xref: EMBL:M64283 xref: EMBL:M85289 xref: EMBL:S76436 xref: EMBL:X62515 xref: HGNC:HGNC:5273 xref: UniGene:Hs.705374 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005964 ! PGBM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005304 name: HPGD_human def: "15-hydroxyprostaglandin dehydrogenase [NAD+] gene" [UniProtKB:P15428] synonym: "PGDH1" EXACT [UniProtKB:P15428] xref: EMBL:BC018986 xref: EMBL:J05594 xref: EMBL:L76465 xref: HGNC:HGNC:5154 xref: UniGene:Hs.655491 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001523 ! PGDH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005306 name: PHB_human def: "Prohibitin gene" [UniProtKB:P35232] xref: EMBL:BC013401 xref: EMBL:BC095460 xref: EMBL:BT007411 xref: EMBL:L14272 xref: EMBL:S85655 xref: HGNC:HGNC:8912 xref: UniGene:Hs.514303 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001591 ! PHB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005307 name: PHC1_human def: "Polyhomeotic-like protein 1 gene" [UniProtKB:P78364] synonym: "EDR1" EXACT [UniProtKB:P78364] synonym: "PH1" EXACT [UniProtKB:P78364] xref: EMBL:BC002871 xref: EMBL:BC017748 xref: EMBL:U89277 xref: HGNC:HGNC:3182 xref: UniGene:Hs.305985 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005264 ! PHC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005308 name: PHC2_human def: "Polyhomeotic-like protein 2 gene" [UniProtKB:Q8IXK0] synonym: "EDR2" EXACT [UniProtKB:Q8IXK0] synonym: "PH2" EXACT [UniProtKB:Q8IXK0] xref: EMBL:AJ242730 xref: EMBL:AJ419231 xref: EMBL:AK128821 xref: EMBL:AL513327 xref: EMBL:BC015450 xref: EMBL:BC028396 xref: EMBL:BC029269 xref: EMBL:BC068573 xref: EMBL:BC092492 xref: EMBL:BC110863 xref: EMBL:BC130630 xref: HGNC:HGNC:3183 xref: UniGene:Hs.524271 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005978 ! PHC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005309 name: PHYHIP_human def: "Phytanoyl-CoA hydroxylase-interacting protein gene" [UniProtKB:Q92561] synonym: "DYRK1AP3" EXACT [UniProtKB:Q92561] synonym: "KIAA0273" EXACT [UniProtKB:Q92561] xref: EMBL:BC034034 xref: EMBL:BC035940 xref: EMBL:D87463 xref: HGNC:HGNC:16865 xref: UniGene:Hs.334688 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006241 ! PHYIP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005310 name: PIAS1_human def: "E3 SUMO-protein ligase PIAS1 gene" [UniProtKB:O75925] synonym: "DDXBP1" EXACT [UniProtKB:O75925] xref: EMBL:AF077951 xref: EMBL:AF167160 xref: EMBL:BC118587 xref: EMBL:BC121797 xref: EMBL:U78524 xref: HGNC:HGNC:2752 xref: UniGene:Hs.162458 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005579 ! PIAS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005311 name: PIAS2_human def: "E3 SUMO-protein ligase PIAS2 gene" [UniProtKB:O75928] synonym: "PIASX" EXACT [UniProtKB:O75928] xref: EMBL:AF077953 xref: EMBL:AF077954 xref: EMBL:AF361054 xref: EMBL:BC015190 xref: HGNC:HGNC:17311 xref: UniGene:Hs.658013 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005321 ! PIAS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005312 name: PIAS4_human def: "E3 SUMO-protein ligase PIAS4 gene" [UniProtKB:Q8N2W9] synonym: "PIASG" EXACT [UniProtKB:Q8N2W9] xref: EMBL:AF077952 xref: EMBL:AF164437 xref: EMBL:BC010047 xref: EMBL:BC029874 xref: EMBL:BC066895 xref: HGNC:HGNC:17002 xref: UniGene:Hs.105779 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005402 ! PIAS4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005313 name: PICK1_human def: "PRKCA-binding protein gene" [UniProtKB:Q9NRD5] synonym: "PRKCABP" EXACT [UniProtKB:Q9NRD5] xref: EMBL:AB026491 xref: EMBL:AF231710 xref: EMBL:AL031587 xref: EMBL:AL049654 xref: EMBL:BC017561 xref: EMBL:CR456550 xref: HGNC:HGNC:9394 xref: UniGene:Hs.180871 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005947 ! PICK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005315 name: PIM2_human def: "Serine/threonine-protein kinase Pim-2 gene" [UniProtKB:Q9P1W9] xref: EMBL:AB042425 xref: EMBL:BC018111 xref: EMBL:U77735 xref: HGNC:HGNC:8987 xref: UniGene:Hs.496096 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002185 ! PIM2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005316 name: PIN1_human def: "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 gene" [UniProtKB:Q13526] xref: EMBL:BC002899 xref: EMBL:BT019331 xref: EMBL:CR407654 xref: EMBL:U49070 xref: HGNC:HGNC:8988 xref: UniGene:Hs.465849 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001755 ! PIN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005317 name: PNN_human def: "Pinin gene" [UniProtKB:Q9H307] synonym: "DRS" EXACT [UniProtKB:Q9H307] synonym: "MEMA" EXACT [UniProtKB:Q9H307] xref: EMBL:AF112222 xref: EMBL:AF195139 xref: EMBL:AK223612 xref: EMBL:BC062602 xref: EMBL:U77718 xref: EMBL:Y09703 xref: EMBL:Y10351 xref: HGNC:HGNC:9162 xref: UniGene:Hs.409965 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002131 ! PININ_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005318 name: PINX1_human def: "Pin2-interacting protein X1 gene" [UniProtKB:Q96BK5] synonym: "LPTL" EXACT [UniProtKB:Q96BK5] synonym: "LPTS" EXACT [UniProtKB:Q96BK5] xref: EMBL:AF205718 xref: EMBL:AF418553 xref: EMBL:AJ344104 xref: EMBL:AK000572 xref: EMBL:AY029161 xref: EMBL:AY238941 xref: EMBL:BC015479 xref: EMBL:BC093762 xref: UniGene:Hs.490991 xref: UniGene:Hs.583894 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002033 ! PINX1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005320 name: PJA1_human def: "E3 ubiquitin-protein ligase Praja1 gene" [UniProtKB:Q8NG27] synonym: "RNF70" EXACT [UniProtKB:Q8NG27] xref: EMBL:AF262024 xref: EMBL:AF264620 xref: EMBL:AK021892 xref: EMBL:AL157699 xref: EMBL:BC048323 xref: EMBL:BC075803 xref: EMBL:BC105051 xref: EMBL:BC105053 xref: HGNC:HGNC:16648 xref: UniGene:Hs.522679 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006202 ! PJA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005323 name: ZMYND8_human def: "Protein kinase C-binding protein 1 gene" [UniProtKB:Q9ULU4] synonym: "KIAA1125" EXACT [UniProtKB:Q9ULU4] synonym: "PRKCBP1" EXACT [UniProtKB:Q9ULU4] synonym: "RACK7" EXACT [UniProtKB:Q9ULU4] xref: EMBL:AB032951 xref: EMBL:AF233453 xref: EMBL:AF273045 xref: EMBL:AF454056 xref: EMBL:AL031666 xref: EMBL:AL049540 xref: EMBL:AL390212 xref: EMBL:BC030721 xref: EMBL:BX641005 xref: EMBL:DQ082998 xref: EMBL:DQ082999 xref: EMBL:U48251 xref: HGNC:HGNC:9397 xref: UniGene:Hs.446240 xref: UniGene:Hs.658553 xref: UniGene:Hs.668465 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005935 ! PKCB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005325 name: PLEKHA4_human def: "Pleckstrin homology domain-containing family A member 4 gene" [UniProtKB:Q9H4M7] synonym: "PEPP1" EXACT [UniProtKB:Q9H4M7] xref: EMBL:AY007233 xref: EMBL:BC024157 xref: EMBL:BC033832 xref: EMBL:BC064601 xref: HGNC:HGNC:14339 xref: UniGene:Hs.9469 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006216 ! PKHA4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005326 name: PLEKHB2_human def: "Pleckstrin homology domain-containing family B member 2 gene" [UniProtKB:Q96CS7] synonym: "EVT2" EXACT [UniProtKB:Q96CS7] xref: EMBL:AK000790 xref: EMBL:BC001428 xref: EMBL:BC013991 xref: EMBL:BC050695 xref: HGNC:HGNC:19236 xref: UniGene:Hs.469944 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005569 ! PKHB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005328 name: PLEKHO1_human def: "Pleckstrin homology domain-containing family O member 1 gene" [UniProtKB:Q53GL0] synonym: "CKIP1" EXACT [UniProtKB:Q53GL0] synonym: "HQ0024c" EXACT [UniProtKB:Q53GL0] synonym: "OC120" EXACT [UniProtKB:Q53GL0] xref: EMBL:AF073836 xref: EMBL:AF168676 xref: EMBL:AF192912 xref: EMBL:AF217956 xref: EMBL:AF291105 xref: EMBL:AK222921 xref: EMBL:AL358073 xref: EMBL:BC010149 xref: EMBL:BC023533 xref: EMBL:CH471121 xref: HGNC:HGNC:24310 xref: UniGene:Hs.438824 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001838 ! PKHO1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005329 name: PKN1_human def: "Serine/threonine-protein kinase N1 gene" [UniProtKB:Q16512] synonym: "PKN" EXACT [UniProtKB:Q16512] synonym: "PRK1" EXACT [UniProtKB:Q16512] synonym: "PRKCL1" EXACT [UniProtKB:Q16512] xref: EMBL:BC040061 xref: EMBL:D26181 xref: EMBL:S75546 xref: EMBL:U33053 xref: HGNC:HGNC:9405 xref: UniGene:Hs.466044 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006068 ! PKN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005330 name: PKP2_human def: "Plakophilin-2 gene" [UniProtKB:Q99959] xref: EMBL:X97675 xref: HGNC:HGNC:9024 xref: UniGene:Hs.164384 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005826 ! PKP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005332 name: PLAGL1_human def: "Zinc finger protein PLAGL1 gene" [UniProtKB:Q9UM63] synonym: "LOT1" EXACT [UniProtKB:Q9UM63] synonym: "ZAC" EXACT [UniProtKB:Q9UM63] xref: EMBL:AJ006354 xref: EMBL:AJ303119 xref: EMBL:AJ311395 xref: EMBL:AL049844 xref: EMBL:BC074814 xref: EMBL:BC109085 xref: EMBL:BC109086 xref: EMBL:BX537397 xref: EMBL:CH471051 xref: EMBL:U72621 xref: EMBL:U81992 xref: HGNC:HGNC:9046 xref: UniGene:Hs.444975 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002231 ! PLAL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005334 name: PLCG1_human def: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 gene" [UniProtKB:P19174] synonym: "PLC1" EXACT [UniProtKB:P19174] xref: EMBL:AL022394 xref: EMBL:DQ297143 xref: EMBL:M34667 xref: HGNC:HGNC:9065 xref: UniGene:Hs.268177 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005610 ! PLCG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005335 name: PLDN_human def: "Pallidin gene" [UniProtKB:Q9UL45] synonym: "PA" EXACT [UniProtKB:Q9UL45] xref: EMBL:AF080470 xref: EMBL:AK057545 xref: EMBL:BC004819 xref: HGNC:HGNC:8549 xref: UniGene:Hs.7037 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005183 ! PLDN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005337 name: PLK1_human def: "Serine/threonine-protein kinase PLK1 gene" [UniProtKB:P53350] synonym: "PLK" EXACT [UniProtKB:P53350] xref: EMBL:BC002369 xref: EMBL:BC003002 xref: EMBL:BC014846 xref: EMBL:L19559 xref: EMBL:U01038 xref: EMBL:U78073 xref: EMBL:X73458 xref: EMBL:X75932 xref: EMBL:X90725 xref: HGNC:HGNC:9077 xref: UniGene:Hs.592049 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001663 ! PLK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005342 name: PLXNB3_human def: "Plexin-B3 precursor gene" [UniProtKB:Q9ULL4] synonym: "KIAA1206" EXACT [UniProtKB:Q9ULL4] synonym: "PLXN6" EXACT [UniProtKB:Q9ULL4] xref: EMBL:AB033032 xref: EMBL:AF149019 xref: HGNC:HGNC:9105 xref: UniGene:Hs.632833 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005547 ! PLXB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005343 name: PMF1_human def: "Polyamine-modulated factor 1 gene" [UniProtKB:Q6P1K2] xref: EMBL:AF141308 xref: EMBL:AF141309 xref: EMBL:AF141310 xref: EMBL:AL080101 xref: EMBL:AL135927 xref: EMBL:BC033656 xref: EMBL:BC050735 xref: EMBL:BC056417 xref: EMBL:BC065031 xref: HGNC:HGNC:9112 xref: UniGene:Hs.530479 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001912 ! PMF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005344 name: PML_human def: "Probable transcription factor PML gene" [UniProtKB:P29590] synonym: "MYL" EXACT [UniProtKB:P29590] synonym: "RNF71" EXACT [UniProtKB:P29590] synonym: "TRIM19" EXACT [UniProtKB:P29590] xref: EMBL:AB067754 xref: EMBL:AF230401 xref: EMBL:BC000080 xref: EMBL:BC020994 xref: EMBL:BT009911 xref: EMBL:M73778 xref: EMBL:M79462 xref: EMBL:M79463 xref: EMBL:M79464 xref: EMBL:M80185 xref: EMBL:X63131 xref: EMBL:X64800 xref: HGNC:HGNC:9113 xref: UniGene:Hs.526464 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001570 ! PML_HUMAN relationship: codes_for CCO:B0005644 ! Q9BWP7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005345 name: PMS1_human def: "PMS1 protein homolog 1 gene" [UniProtKB:P54277] synonym: "PMSL1" EXACT [UniProtKB:P54277] xref: EMBL:AY267352 xref: EMBL:U13695 xref: HGNC:HGNC:9121 xref: UniGene:Hs.111749 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001668 ! PMS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005346 name: PMS2_human def: "Mismatch repair endonuclease PMS2 gene" [UniProtKB:P54278] synonym: "PMSL2" EXACT [UniProtKB:P54278] xref: EMBL:AB103082 xref: EMBL:AB103083 xref: EMBL:AB103085 xref: EMBL:AC005995 xref: EMBL:BC093921 xref: EMBL:U13696 xref: EMBL:U14658 xref: HGNC:HGNC:9122 xref: UniGene:Hs.632637 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001669 ! PMS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005347 name: PKMYT1_human def: "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase gene" [UniProtKB:Q99640] synonym: "MYT1" EXACT [UniProtKB:Q99640] xref: EMBL:AC004233 xref: EMBL:AC004235 xref: EMBL:AF014118 xref: EMBL:AF549406 xref: EMBL:AL713779 xref: EMBL:U56816 xref: HGNC:HGNC:29650 xref: UniGene:Hs.77783 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002078 ! PMYT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005348 name: PNMA1_human def: "Paraneoplastic antigen Ma1 gene" [UniProtKB:Q8ND90] synonym: "MA1" EXACT [UniProtKB:Q8ND90] xref: EMBL:AF037364 xref: EMBL:AF320308 xref: EMBL:AL834327 xref: EMBL:BC039577 xref: HGNC:HGNC:9158 xref: UniGene:Hs.194709 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005877 ! PNMA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005349 name: PNO1_human def: "RNA-binding protein PNO1 gene" [UniProtKB:Q9NRX1] xref: EMBL:AC017083 xref: EMBL:AF164799 xref: EMBL:AF349314 xref: EMBL:AK223118 xref: EMBL:BC008304 xref: EMBL:BC018152 xref: HGNC:HGNC:32790 xref: UniGene:Hs.262858 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006240 ! PNO1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005350 name: NP_human def: "Purine nucleoside phosphorylase gene" [UniProtKB:P00491] synonym: "PNP" EXACT [UniProtKB:P00491] xref: EMBL:AY817667 xref: EMBL:BC104206 xref: EMBL:BC104207 xref: EMBL:BC106074 xref: EMBL:CR407607 xref: EMBL:J02672 xref: EMBL:M13951 xref: EMBL:M13952 xref: EMBL:M13953 xref: EMBL:X00737 xref: HGNC:HGNC:7892 xref: UniGene:Hs.75514 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006097 ! PNPH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005351 name: POU2F1_human def: "POU domain, class 2, transcription factor 1 gene" [UniProtKB:P14859] synonym: "OCT1" EXACT [UniProtKB:P14859] synonym: "OTF1" EXACT [UniProtKB:P14859] xref: EMBL:AL136984 xref: EMBL:AY113189 xref: EMBL:BC001664 xref: EMBL:BC003571 xref: EMBL:BC007388 xref: EMBL:BC052274 xref: EMBL:X13403 xref: HGNC:HGNC:9212 xref: UniGene:Hs.493649 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006069 ! PO2F1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005352 name: POU2F3_human def: "POU domain, class 2, transcription factor 3 gene" [UniProtKB:Q9UKI9] synonym: "OTF11" EXACT [UniProtKB:Q9UKI9] synonym: "PLA1" EXACT [UniProtKB:Q9UKI9] xref: EMBL:AF133895 xref: EMBL:AF162278 xref: EMBL:AJ012214 xref: HGNC:HGNC:19864 xref: UniGene:Hs.227115 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006049 ! PO2F3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005353 name: POU3F3_human def: "POU domain, class 3, transcription factor 3 gene" [UniProtKB:P20264] synonym: "BRN1" EXACT [UniProtKB:P20264] synonym: "OTF8" EXACT [UniProtKB:P20264] xref: EMBL:AB001835 xref: HGNC:HGNC:9216 xref: UniGene:Hs.673855 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006341 ! PO3F3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005354 name: POLS_human def: "DNA polymerase sigma gene" [UniProtKB:Q5XG87] synonym: "TRF4" EXACT [UniProtKB:Q5XG87] xref: EMBL:AB005754 xref: EMBL:AF089896 xref: EMBL:AY623114 xref: EMBL:BC084567 xref: EMBL:BC117137 xref: EMBL:BC126106 xref: HGNC:HGNC:16705 xref: UniGene:Hs.481542 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001902 ! POLS_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005355 name: POT1_human def: "Protection of telomeres protein 1 gene" [UniProtKB:Q9NUX5] xref: EMBL:AC004925 xref: EMBL:AC096665 xref: EMBL:AC110791 xref: EMBL:AK001230 xref: EMBL:AK001935 xref: EMBL:AK022580 xref: EMBL:AK026234 xref: EMBL:AL050120 xref: EMBL:BC002923 xref: HGNC:HGNC:17284 xref: UniGene:Hs.31968 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005503 ! POTE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005356 name: PPP1CA_human def: "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit gene" [UniProtKB:P62136] synonym: "PPP1A" EXACT [UniProtKB:P62136] xref: EMBL:BC001888 xref: EMBL:BC004482 xref: EMBL:BC008010 xref: EMBL:BT006629 xref: EMBL:J04759 xref: EMBL:M63960 xref: EMBL:X70848 xref: HGNC:HGNC:9281 xref: UniGene:Hs.183994 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001688 ! PP1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005357 name: PPP1CB_human def: "Serine/threonine-protein phosphatase PP1-beta catalytic subunit gene" [UniProtKB:P62140] xref: EMBL:AC097724 xref: EMBL:AF092905 xref: EMBL:BC002697 xref: EMBL:BC012045 xref: EMBL:BT019744 xref: EMBL:CR542263 xref: EMBL:CR542285 xref: EMBL:U10998 xref: EMBL:U10999 xref: EMBL:U11000 xref: EMBL:U11001 xref: EMBL:U11002 xref: EMBL:U11003 xref: EMBL:U11004 xref: EMBL:U11005 xref: EMBL:X80910 xref: HGNC:HGNC:9282 xref: UniGene:Hs.591571 xref: UniGene:Hs.705383 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001689 ! PP1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005358 name: PPP1CC_human def: "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit gene" [UniProtKB:P36873] xref: EMBL:BC014073 xref: EMBL:L07395 xref: EMBL:X74008 xref: HGNC:HGNC:9283 xref: UniGene:Hs.79081 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001596 ! PP1G_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005359 name: PPP2CA_human def: "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform gene" [UniProtKB:P67775] xref: EMBL:BC000400 xref: EMBL:BC002657 xref: EMBL:BC019275 xref: EMBL:BC031696 xref: EMBL:J03804 xref: EMBL:M60483 xref: EMBL:X12646 xref: HGNC:HGNC:9299 xref: UniGene:Hs.483408 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001697 ! PP2AA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005362 name: PPARG_human def: "Peroxisome proliferator-activated receptor gamma gene" [UniProtKB:P37231] synonym: "NR1C3" EXACT [UniProtKB:P37231] xref: EMBL:AB005526 xref: EMBL:AY157024 xref: EMBL:BC006811 xref: EMBL:BT007281 xref: EMBL:D83233 xref: EMBL:L40904 xref: EMBL:U63415 xref: EMBL:U79012 xref: EMBL:X90563 xref: HGNC:HGNC:9236 xref: UniGene:Hs.162646 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005616 ! PPARG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005363 name: PPAPDC1B_human def: "Phosphatidic acid phosphatase type 2 domain-containing protein 1B gene" [UniProtKB:Q8NEB5] synonym: "HTPAP" EXACT [UniProtKB:Q8NEB5] xref: EMBL:AF212238 xref: EMBL:BC033025 xref: EMBL:BC106014 xref: HGNC:HGNC:25026 xref: UniGene:Hs.567619 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001978 ! PPC1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005364 name: PPIA_human def: "Peptidyl-prolyl cis-trans isomerase A gene" [UniProtKB:P62937] synonym: "CYPA" EXACT [UniProtKB:P62937] xref: EMBL:AY739283 xref: EMBL:BC000689 xref: EMBL:BC003026 xref: EMBL:BC005320 xref: EMBL:BC005982 xref: EMBL:BC007104 xref: EMBL:BC013915 xref: EMBL:BC073992 xref: EMBL:BC106030 xref: EMBL:CR456707 xref: EMBL:X52851 xref: EMBL:Y00052 xref: HGNC:HGNC:9253 xref: UniGene:Hs.356331 xref: UniGene:Hs.598115 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006072 ! PPIA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005365 name: PPIB_human def: "Peptidyl-prolyl cis-trans isomerase B precursor gene" [UniProtKB:P23284] synonym: "CYPB" EXACT [UniProtKB:P23284] xref: EMBL:AY962310 xref: EMBL:BC001125 xref: EMBL:BC008848 xref: EMBL:BC020800 xref: EMBL:BC032138 xref: EMBL:M60457 xref: EMBL:M60857 xref: EMBL:M63573 xref: HGNC:HGNC:9255 xref: UniGene:Hs.434937 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006327 ! PPIB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005366 name: PPM1A_human def: "Protein phosphatase 1A gene" [UniProtKB:P35813] synonym: "PPPM1A" EXACT [UniProtKB:P35813] xref: EMBL:AF070670 xref: EMBL:BC026691 xref: EMBL:BC063243 xref: EMBL:S87759 xref: HGNC:HGNC:9275 xref: UniGene:Hs.592298 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005649 ! PPM1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005367 name: PPM1D_human def: "Protein phosphatase 1D gene" [UniProtKB:O15297] synonym: "WIP1" EXACT [UniProtKB:O15297] xref: EMBL:BC016480 xref: EMBL:U78305 xref: HGNC:HGNC:9277 xref: UniGene:Hs.591184 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001372 ! PPM1D_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005368 name: PPM1G_human def: "Protein phosphatase 1G gene" [UniProtKB:O15355] synonym: "PPM1C" EXACT [UniProtKB:O15355] xref: EMBL:BC000057 xref: EMBL:BC022061 xref: EMBL:Y13936 xref: HGNC:HGNC:9278 xref: UniGene:Hs.699225 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001375 ! PPM1G_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005369 name: PPP5C_human def: "Serine/threonine-protein phosphatase 5 gene" [UniProtKB:P53041] synonym: "PPP5" EXACT [UniProtKB:P53041] xref: EMBL:AC007193 xref: EMBL:BC001970 xref: EMBL:U25174 xref: EMBL:X89416 xref: EMBL:X92121 xref: HGNC:HGNC:9322 xref: UniGene:Hs.654604 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001662 ! PPP5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005370 name: PPP6C_human def: "Serine/threonine-protein phosphatase 6 gene" [UniProtKB:O00743] synonym: "PPP6" EXACT [UniProtKB:O00743] xref: EMBL:AF035158 xref: EMBL:AL445930 xref: EMBL:BC006990 xref: EMBL:BT019708 xref: EMBL:CH471090 xref: EMBL:X92972 xref: HGNC:HGNC:9323 xref: UniGene:Hs.584019 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001353 ! PPP6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005371 name: PQBP1_human def: "Polyglutamine-binding protein 1 gene" [UniProtKB:O60828] synonym: "JM26" EXACT [UniProtKB:O60828] synonym: "NPW38" EXACT [UniProtKB:O60828] xref: EMBL:AB016533 xref: EMBL:AB041832 xref: EMBL:AB041833 xref: EMBL:AB041834 xref: EMBL:AB041835 xref: EMBL:AB041836 xref: EMBL:AJ005893 xref: EMBL:AJ242829 xref: EMBL:AJ973593 xref: EMBL:AJ973594 xref: EMBL:AJ973595 xref: EMBL:AJ973596 xref: EMBL:AJ973597 xref: EMBL:AJ973598 xref: EMBL:AJ973599 xref: EMBL:AJ973600 xref: EMBL:AJ973601 xref: EMBL:AJ973602 xref: EMBL:AJ973603 xref: EMBL:AJ973605 xref: EMBL:AJ973606 xref: EMBL:AJ973607 xref: EMBL:BC012358 xref: HGNC:HGNC:9330 xref: UniGene:Hs.534384 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006218 ! PQBP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005372 name: PRIC285_human def: "Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein gene" [UniProtKB:Q9BYK8] synonym: "KIAA1769" EXACT [UniProtKB:Q9BYK8] xref: EMBL:AB051556 xref: EMBL:AB201715 xref: EMBL:AF517673 xref: EMBL:AK055611 xref: EMBL:AK074171 xref: EMBL:AL121829 xref: UniGene:Hs.517180 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006035 ! PR285_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005373 name: PRC1_human def: "Protein regulator of cytokinesis 1 gene" [UniProtKB:O43663] xref: EMBL:AF044588 xref: EMBL:BC003138 xref: EMBL:BC005140 xref: HGNC:HGNC:9341 xref: UniGene:Hs.567385 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001394 ! PRC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005374 name: PPARGC1A_human def: "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha gene" [UniProtKB:Q9UBK2] synonym: "LEM6" EXACT [UniProtKB:Q9UBK2] synonym: "PGC1" EXACT [UniProtKB:Q9UBK2] synonym: "PGC1A" EXACT [UniProtKB:Q9UBK2] synonym: "PPARGC1" EXACT [UniProtKB:Q9UBK2] xref: EMBL:AF106698 xref: EMBL:AF108193 xref: EMBL:AF108194 xref: EMBL:AF108195 xref: EMBL:AF108196 xref: EMBL:AF108197 xref: EMBL:AF108198 xref: EMBL:AF108199 xref: EMBL:AF108200 xref: EMBL:AF108201 xref: EMBL:AF108202 xref: EMBL:AF108203 xref: EMBL:AF108204 xref: EMBL:AF108205 xref: EMBL:AF159714 xref: EMBL:AF186379 xref: HGNC:HGNC:9237 xref: UniGene:Hs.527078 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006031 ! PRGC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005375 name: PRIM1_human def: "DNA primase small subunit gene" [UniProtKB:P49642] xref: EMBL:BC005266 xref: EMBL:U89689 xref: EMBL:X74330 xref: HGNC:HGNC:9369 xref: UniGene:Hs.534339 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005507 ! PRI1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005377 name: PARK2_human def: "E3 ubiquitin-protein ligase parkin gene" [UniProtKB:O60260] synonym: "PRKN" EXACT [UniProtKB:O60260] xref: EMBL:AB009973 xref: EMBL:AF381282 xref: EMBL:AF381283 xref: EMBL:AF381286 xref: EMBL:AL035697 xref: EMBL:AL132982 xref: EMBL:AL445215 xref: EMBL:AP000886 xref: EMBL:AP000887 xref: EMBL:AP001576 xref: EMBL:AP001577 xref: EMBL:AP001578 xref: EMBL:AP003699 xref: EMBL:AY564225 xref: EMBL:BC022014 xref: HGNC:HGNC:8607 xref: UniGene:Hs.132954 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006227 ! PRKN2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005378 name: PRM2_human def: "Protamine-2 gene" [UniProtKB:P04554] xref: EMBL:AF215713 xref: EMBL:BC005303 xref: EMBL:BC066338 xref: EMBL:M60332 xref: EMBL:U15422 xref: EMBL:X07862 xref: EMBL:Z46940 xref: HGNC:HGNC:9448 xref: UniGene:Hs.2324 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001482 ! PRM2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005379 name: PRM3_human def: "Protamine-3 gene" [UniProtKB:Q9NNZ6] xref: EMBL:Z46940 xref: HGNC:HGNC:13732 xref: UniGene:Hs.259636 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002149 ! PRM3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005380 name: PFN1_human def: "Profilin-1 gene" [UniProtKB:P07737] xref: EMBL:BC002475 xref: EMBL:BC006768 xref: EMBL:BC013439 xref: EMBL:BC015164 xref: EMBL:BC057828 xref: EMBL:J03191 xref: HGNC:HGNC:8881 xref: UniGene:Hs.494691 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006154 ! PROF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005381 name: PFN2_human def: "Profilin-2 gene" [UniProtKB:P35080] xref: EMBL:AF228738 xref: EMBL:BC002964 xref: EMBL:BC018049 xref: EMBL:BC043646 xref: EMBL:L10678 xref: HGNC:HGNC:8882 xref: UniGene:Hs.91747 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006155 ! PROF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005384 name: PSMC1_human def: "26S protease regulatory subunit 4 gene" [UniProtKB:P62191] xref: EMBL:BC000512 xref: EMBL:BC016368 xref: EMBL:BC073818 xref: EMBL:CR457044 xref: EMBL:L02426 xref: HGNC:HGNC:9547 xref: UniGene:Hs.356654 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005314 ! PRS4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005385 name: PSMA1_human def: "Proteasome subunit alpha type-1 gene" [UniProtKB:P25786] synonym: "PROS30" EXACT [UniProtKB:P25786] synonym: "PSC2" EXACT [UniProtKB:P25786] xref: EMBL:BC002577 xref: EMBL:BC005932 xref: EMBL:BC008472 xref: EMBL:BC009576 xref: EMBL:BC015105 xref: EMBL:BC015356 xref: EMBL:BC022372 xref: EMBL:D00759 xref: EMBL:M64992 xref: EMBL:X61969 xref: HGNC:HGNC:9530 xref: UniGene:Hs.102798 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005233 ! PSA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005386 name: PSMA3_human def: "Proteasome subunit alpha type-3 gene" [UniProtKB:P25788] synonym: "PSC8" EXACT [UniProtKB:P25788] xref: EMBL:BC005265 xref: EMBL:BC029402 xref: EMBL:BC038990 xref: EMBL:BT006711 xref: EMBL:BT019715 xref: EMBL:D00762 xref: HGNC:HGNC:9532 xref: UniGene:Hs.558799 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005991 ! PSA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005387 name: PSMB10_human def: "Proteasome subunit beta type-10 precursor gene" [UniProtKB:P40306] synonym: "MECL1" EXACT [UniProtKB:P40306] xref: EMBL:BC017198 xref: EMBL:BC052369 xref: EMBL:BT019723 xref: EMBL:BT019724 xref: EMBL:X71874 xref: EMBL:Y13640 xref: HGNC:HGNC:9538 xref: UniGene:Hs.9661 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006219 ! PSB10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005388 name: PSMD11_human def: "26S proteasome non-ATPase regulatory subunit 11 gene" [UniProtKB:O00231] xref: EMBL:AB003102 xref: EMBL:AF001212 xref: EMBL:BC000437 xref: EMBL:BC004430 xref: HGNC:HGNC:9556 xref: UniGene:Hs.655396 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006103 ! PSD11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005389 name: PSG9_human def: "Pregnancy-specific beta-1-glycoprotein 9 precursor gene" [UniProtKB:Q00887] synonym: "PSG11" EXACT [UniProtKB:Q00887] xref: EMBL:AC005392 xref: EMBL:AF106557 xref: EMBL:AF106558 xref: EMBL:BC020759 xref: EMBL:M34421 xref: EMBL:M34481 xref: EMBL:M38046 xref: EMBL:M38243 xref: EMBL:M58591 xref: EMBL:U04325 xref: EMBL:X17610 xref: HGNC:HGNC:9526 xref: UniGene:Hs.502092 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006157 ! PSG9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005390 name: PSMD1_human def: "26S proteasome non-ATPase regulatory subunit 1 gene" [UniProtKB:Q99460] xref: EMBL:AC009407 xref: EMBL:BC001053 xref: EMBL:BC014013 xref: EMBL:BC039845 xref: EMBL:BC047897 xref: EMBL:BC064398 xref: EMBL:BC073833 xref: EMBL:BC094720 xref: EMBL:BC112344 xref: EMBL:BC114434 xref: EMBL:D44466 xref: HGNC:HGNC:9554 xref: UniGene:Hs.3887 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002066 ! PSMD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005391 name: PSMD2_human def: "26S proteasome non-ATPase regulatory subunit 2 gene" [UniProtKB:Q13200] synonym: "TRAP2" EXACT [UniProtKB:Q13200] xref: EMBL:BC002368 xref: EMBL:BC002997 xref: EMBL:BC007897 xref: EMBL:D78151 xref: EMBL:U12596 xref: EMBL:X86446 xref: HGNC:HGNC:9559 xref: UniGene:Hs.518464 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001745 ! PSMD2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005392 name: PSMD8_human def: "26S proteasome non-ATPase regulatory subunit 8 gene" [UniProtKB:P48556] xref: EMBL:AC005789 xref: EMBL:BC001164 xref: EMBL:D38047 xref: HGNC:HGNC:9566 xref: UniGene:Hs.78466 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001625 ! PSMD8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005393 name: PSME1_human def: "Proteasome activator complex subunit 1 gene" [UniProtKB:Q06323] synonym: "IFI5111" EXACT [UniProtKB:Q06323] xref: EMBL:AB007137 xref: EMBL:AF078829 xref: EMBL:BC000352 xref: EMBL:BC007503 xref: EMBL:BT019337 xref: EMBL:L07633 xref: EMBL:U10360 xref: HGNC:HGNC:9568 xref: UniGene:Hs.75348 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006215 ! PSME1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005395 name: PTCH1_human def: "Protein patched homolog 1 gene" [UniProtKB:Q13635] synonym: "PTCH" EXACT [UniProtKB:Q13635] xref: EMBL:AL161729 xref: EMBL:U43148 xref: EMBL:U59464 xref: HGNC:HGNC:9585 xref: UniGene:Hs.494538 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001765 ! PTC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005396 name: PTEN_human def: "Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN gene" [UniProtKB:P60484] synonym: "MMAC1" EXACT [UniProtKB:P60484] synonym: "TEP1" EXACT [UniProtKB:P60484] xref: EMBL:AF000726 xref: EMBL:AF000727 xref: EMBL:AF000728 xref: EMBL:AF000729 xref: EMBL:AF000730 xref: EMBL:AF000731 xref: EMBL:AF000732 xref: EMBL:AF000733 xref: EMBL:AF000734 xref: EMBL:AF067844 xref: EMBL:AF143312 xref: EMBL:AF143313 xref: EMBL:AF143314 xref: EMBL:AF143315 xref: EMBL:BC005821 xref: EMBL:CR450306 xref: EMBL:DQ073384 xref: EMBL:U92436 xref: EMBL:U93051 xref: EMBL:U96180 xref: HGNC:HGNC:9588 xref: UniGene:Hs.500466 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001685 ! PTEN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005399 name: PTPN6_human def: "Tyrosine-protein phosphatase non-receptor type 6 gene" [UniProtKB:P29350] synonym: "HCP" EXACT [UniProtKB:P29350] synonym: "PTP1C" EXACT [UniProtKB:P29350] xref: EMBL:AB079851 xref: EMBL:BC002523 xref: EMBL:BC007667 xref: EMBL:M74903 xref: EMBL:M77273 xref: EMBL:U15528 xref: EMBL:U15529 xref: EMBL:U15530 xref: EMBL:U15531 xref: EMBL:U15532 xref: EMBL:U15533 xref: EMBL:U15534 xref: EMBL:U15535 xref: EMBL:U15536 xref: EMBL:U15537 xref: EMBL:U47924 xref: EMBL:X62055 xref: HGNC:HGNC:9658 xref: UniGene:Hs.63489 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005608 ! PTN6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005400 name: PTN_human def: "Pleiotrophin precursor gene" [UniProtKB:P21246] synonym: "HBNF1" EXACT [UniProtKB:P21246] synonym: "NEGF1" EXACT [UniProtKB:P21246] xref: EMBL:AB004306 xref: EMBL:BC005916 xref: EMBL:D90226 xref: EMBL:M57399 xref: EMBL:S50394 xref: EMBL:S50405 xref: EMBL:S50408 xref: EMBL:S50409 xref: EMBL:S59641 xref: EMBL:S60110 xref: EMBL:S60111 xref: EMBL:S60736 xref: EMBL:X52946 xref: HGNC:HGNC:9630 xref: UniGene:Hs.371249 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001541 ! PTN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005401 name: PTOV1_human def: "Prostate tumor overexpressed gene 1 protein gene" [UniProtKB:Q86YD1] synonym: "ACID2" EXACT [UniProtKB:Q86YD1] synonym: "PP642" EXACT [UniProtKB:Q86YD1] synonym: "UNQ6127/PRO20092" EXACT [UniProtKB:Q86YD1] xref: EMBL:AF218026 xref: EMBL:AF238381 xref: EMBL:AJ617480 xref: EMBL:AY358168 xref: EMBL:BC015172 xref: EMBL:BC042921 xref: EMBL:CH471177 xref: HGNC:HGNC:9632 xref: UniGene:Hs.587979 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006294 ! PTOV1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005403 name: PTTG1_human def: "Securin gene" [UniProtKB:O95997] synonym: "EAP1" EXACT [UniProtKB:O95997] synonym: "PTTG" EXACT [UniProtKB:O95997] synonym: "TUTR1" EXACT [UniProtKB:O95997] xref: EMBL:AF075242 xref: EMBL:AF095287 xref: EMBL:AF167560 xref: EMBL:AF167561 xref: EMBL:AF167562 xref: EMBL:AF167563 xref: EMBL:AF167564 xref: EMBL:AJ223953 xref: HGNC:HGNC:9690 xref: UniGene:Hs.350966 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001457 ! PTTG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005404 name: PYGO2_human def: "Pygopus homolog 2 gene" [UniProtKB:Q9BRQ0] synonym: "PP7910" EXACT [UniProtKB:Q9BRQ0] xref: EMBL:AF289598 xref: EMBL:AF457208 xref: EMBL:BC006132 xref: EMBL:BC013725 xref: EMBL:BC032099 xref: HGNC:HGNC:30257 xref: UniGene:Hs.533597 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006062 ! PYGO2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005405 name: KIAA1009_human def: "Protein QN1 homolog gene" [UniProtKB:Q5TB80] synonym: "C6orf84" EXACT [UniProtKB:Q5TB80] synonym: "QN1" EXACT [UniProtKB:Q5TB80] xref: EMBL:AB023226 xref: EMBL:AL138742 xref: EMBL:BC063632 xref: HGNC:HGNC:21107 xref: UniGene:Hs.485865 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001883 ! QN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005406 name: RAD51L1_human def: "DNA repair protein RAD51 homolog 2 gene" [UniProtKB:O15315] synonym: "RAD51B" EXACT [UniProtKB:O15315] synonym: "REC2" EXACT [UniProtKB:O15315] xref: EMBL:AC004518 xref: EMBL:AY138857 xref: EMBL:AY138858 xref: EMBL:AY138859 xref: EMBL:BC030219 xref: EMBL:BX161515 xref: EMBL:BX248061 xref: EMBL:BX248766 xref: EMBL:DQ160197 xref: EMBL:U84138 xref: EMBL:U92074 xref: EMBL:Y15571 xref: HGNC:HGNC:9822 xref: UniGene:Hs.172587 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001373 ! RA51B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005407 name: RAD51L3_human def: "DNA repair protein RAD51 homolog 4 gene" [UniProtKB:O75771] synonym: "RAD51D" EXACT [UniProtKB:O75771] xref: EMBL:AB013341 xref: EMBL:AB016223 xref: EMBL:AB016224 xref: EMBL:AB016225 xref: EMBL:AB018360 xref: EMBL:AB018361 xref: EMBL:AB018362 xref: EMBL:AB018363 xref: EMBL:AB020412 xref: EMBL:AF034956 xref: EMBL:AL117459 xref: EMBL:AY623116 xref: EMBL:BC014422 xref: EMBL:Y15572 xref: HGNC:HGNC:9823 xref: UniGene:Hs.631757 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001434 ! RA51D_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005408 name: RAD54B_human def: "DNA repair and recombination protein RAD54B gene" [UniProtKB:Q9Y620] xref: EMBL:AF112481 xref: EMBL:BC001965 xref: HGNC:HGNC:17228 xref: UniGene:Hs.30561 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002260 ! RA54B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005409 name: RAB1A_human def: "Ras-related protein Rab-1A gene" [UniProtKB:P62820] synonym: "RAB1" EXACT [UniProtKB:P62820] xref: EMBL:AF498929 xref: EMBL:AK055927 xref: EMBL:AL050268 xref: EMBL:BC000905 xref: EMBL:BX571747 xref: EMBL:M28209 xref: HGNC:HGNC:9758 xref: UniGene:Hs.310645 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006222 ! RAB1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005410 name: RAB4A_human def: "Ras-related protein Rab-4A gene" [UniProtKB:P20338] synonym: "RAB4" EXACT [UniProtKB:P20338] xref: EMBL:AF498934 xref: EMBL:BC002438 xref: EMBL:BC004309 xref: EMBL:M28211 xref: HGNC:HGNC:9781 xref: UniGene:Hs.296169 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006295 ! RAB4A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005411 name: RAC1_human def: "Ras-related C3 botulinum toxin substrate 1 precursor gene" [UniProtKB:P63000] synonym: "MIG5" EXACT [UniProtKB:P63000] xref: EMBL:AC009412 xref: EMBL:AF136373 xref: EMBL:AF498964 xref: EMBL:AJ132694 xref: EMBL:AJ132695 xref: EMBL:AY279384 xref: EMBL:BC004247 xref: EMBL:BC050687 xref: EMBL:BC107748 xref: EMBL:BT007121 xref: EMBL:DQ165078 xref: EMBL:M29870 xref: EMBL:M31467 xref: HGNC:HGNC:9801 xref: UniGene:Hs.413812 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005337 ! RAC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005412 name: RAD17_human def: "Cell cycle checkpoint protein RAD17 gene" [UniProtKB:O75943] synonym: "R24L" EXACT [UniProtKB:O75943] xref: EMBL:AF017748 xref: EMBL:AF076838 xref: EMBL:AF085736 xref: EMBL:AF098533 xref: EMBL:AF098534 xref: EMBL:AF112263 xref: EMBL:AF126424 xref: EMBL:AJ001642 xref: EMBL:AJ004977 xref: EMBL:AJ131296 xref: EMBL:AJ131297 xref: EMBL:AJ131298 xref: EMBL:AJ131299 xref: EMBL:AJ131300 xref: EMBL:AJ131301 xref: EMBL:AJ131302 xref: EMBL:AJ131303 xref: EMBL:AJ131304 xref: EMBL:AJ131305 xref: EMBL:AJ131306 xref: EMBL:AJ131307 xref: EMBL:AJ131308 xref: EMBL:AL122068 xref: EMBL:AY612854 xref: EMBL:BC032304 xref: EMBL:BX537441 xref: HGNC:HGNC:9807 xref: UniGene:Hs.16184 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001441 ! RAD17_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005413 name: RAD1_human def: "Cell cycle checkpoint protein RAD1 gene" [UniProtKB:O60671] synonym: "REC1" EXACT [UniProtKB:O60671] xref: EMBL:AB183821 xref: EMBL:AB183822 xref: EMBL:AF011905 xref: EMBL:AF030933 xref: EMBL:AF058392 xref: EMBL:AF073524 xref: EMBL:AF074717 xref: EMBL:AF076841 xref: EMBL:AF084512 xref: EMBL:AF084513 xref: EMBL:AF090170 xref: EMBL:AJ004974 xref: EMBL:AJ004975 xref: EMBL:BC006837 xref: EMBL:BC009804 xref: EMBL:BC037857 xref: EMBL:BT006908 xref: HGNC:HGNC:9806 xref: UniGene:Hs.531879 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001413 ! RAD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005414 name: RAD21_human def: "Double-strand-break repair protein rad21 homolog gene" [UniProtKB:O60216] synonym: "HR21" EXACT [UniProtKB:O60216] synonym: "KIAA0078" EXACT [UniProtKB:O60216] synonym: "NXP1" EXACT [UniProtKB:O60216] xref: EMBL:AY675320 xref: EMBL:BC050381 xref: EMBL:D38551 xref: EMBL:X98294 xref: HGNC:HGNC:9811 xref: UniGene:Hs.81848 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001403 ! RAD21_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005415 name: RAD50_human def: "DNA repair protein RAD50 gene" [UniProtKB:Q92878] xref: EMBL:AF057299 xref: EMBL:AF057300 xref: EMBL:BC062603 xref: EMBL:BC073850 xref: EMBL:U63139 xref: EMBL:Z75311 xref: HGNC:HGNC:9816 xref: UniGene:Hs.655835 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002021 ! RAD50_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005416 name: RAD51_human def: "DNA repair protein RAD51 homolog 1 gene" [UniProtKB:Q06609] synonym: "RAD51A" EXACT [UniProtKB:Q06609] synonym: "RECA" EXACT [UniProtKB:Q06609] xref: EMBL:AF165088 xref: EMBL:AF165089 xref: EMBL:AF165090 xref: EMBL:AF165091 xref: EMBL:AF165092 xref: EMBL:AF165093 xref: EMBL:AF165094 xref: EMBL:AF233740 xref: EMBL:AF233741 xref: EMBL:AF233742 xref: EMBL:AF233743 xref: EMBL:AF233744 xref: EMBL:AF236021 xref: EMBL:AK131299 xref: EMBL:AK291969 xref: EMBL:AY196785 xref: EMBL:BC001459 xref: EMBL:CH471125 xref: EMBL:CR536559 xref: EMBL:D13804 xref: EMBL:D14134 xref: HGNC:HGNC:9817 xref: UniGene:Hs.631709 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001721 ! RAD51_HUMAN relationship: codes_for CCO:B0001923 ! Q6ZNA8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005417 name: RAD52_human def: "DNA repair protein RAD52 homolog gene" [UniProtKB:P43351] xref: EMBL:AY527412 xref: EMBL:L33262 xref: EMBL:U12134 xref: EMBL:U27516 xref: HGNC:HGNC:9824 xref: UniGene:Hs.410355 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001621 ! RAD52_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005418 name: RAD54L_human def: "DNA repair and recombination protein RAD54-like gene" [UniProtKB:Q92698] synonym: "RAD54A" EXACT [UniProtKB:Q92698] xref: EMBL:AL121602 xref: EMBL:AY623117 xref: EMBL:BC121059 xref: EMBL:BC121060 xref: EMBL:X97795 xref: HGNC:HGNC:9826 xref: UniGene:Hs.701999 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002016 ! RAD54_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005419 name: RAD9A_human def: "Cell cycle checkpoint control protein RAD9A gene" [UniProtKB:Q99638] xref: EMBL:AY766122 xref: EMBL:BC014848 xref: EMBL:CR536508 xref: EMBL:U53174 xref: HGNC:HGNC:9827 xref: UniGene:Hs.655354 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002077 ! RAD9A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005421 name: RAF1_human def: "RAF proto-oncogene serine/threonine-protein kinase gene" [UniProtKB:P04049] synonym: "RAF" EXACT [UniProtKB:P04049] xref: EMBL:AY271661 xref: EMBL:BC018119 xref: EMBL:X03484 xref: HGNC:HGNC:9829 xref: UniGene:Hs.159130 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005636 ! RAF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005422 name: RAI1_human def: "Retinoic acid-induced protein 1 gene" [UniProtKB:Q7Z5J4] synonym: "KIAA1820" EXACT [UniProtKB:Q7Z5J4] xref: EMBL:AB058723 xref: EMBL:AJ271790 xref: EMBL:AJ271791 xref: EMBL:AL133649 xref: EMBL:AL834468 xref: EMBL:AL834486 xref: EMBL:AY172136 xref: EMBL:BC021209 xref: HGNC:HGNC:9834 xref: UniGene:Hs.655395 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005192 ! RAI1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005423 name: RANBP3_human def: "Ran-binding protein 3 gene" [UniProtKB:Q9H6Z4] xref: EMBL:AC004602 xref: EMBL:AC005784 xref: EMBL:AC093050 xref: EMBL:AC104532 xref: EMBL:AK025300 xref: EMBL:AL050149 xref: EMBL:BC004349 xref: EMBL:Y08697 xref: EMBL:Y08698 xref: HGNC:HGNC:9850 xref: UniGene:Hs.531752 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005866 ! RANB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005424 name: RANBP1_human def: "Ran-specific GTPase-activating protein gene" [UniProtKB:P43487] xref: EMBL:CR456556 xref: EMBL:D38076 xref: EMBL:X83617 xref: HGNC:HGNC:9847 xref: UniGene:Hs.24763 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005653 ! RANG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005425 name: RAN_human def: "GTP-binding nuclear protein Ran gene" [UniProtKB:P62826] synonym: "ARA24" EXACT [UniProtKB:P62826] synonym: "OK/SW-cl.81" EXACT [UniProtKB:P62826] xref: EMBL:AB062399 xref: EMBL:AF052578 xref: EMBL:AF054183 xref: EMBL:AF501887 xref: EMBL:BC004272 xref: EMBL:BC014518 xref: EMBL:BC014901 xref: EMBL:BC016654 xref: EMBL:BC051908 xref: EMBL:BC072000 xref: EMBL:BT007271 xref: EMBL:CR450347 xref: EMBL:M31469 xref: HGNC:HGNC:9846 xref: UniGene:Hs.10842 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001693 ! RAN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005426 name: RAP1A_human def: "Ras-related protein Rap-1A precursor gene" [UniProtKB:P62834] synonym: "KREV1" EXACT [UniProtKB:P62834] xref: EMBL:AF493912 xref: EMBL:AL049557 xref: EMBL:BC014086 xref: EMBL:M22995 xref: EMBL:X12533 xref: HGNC:HGNC:9855 xref: UniGene:Hs.190334 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001694 ! RAP1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005429 name: RASSF1_human def: "Ras association domain-containing protein 1 gene" [UniProtKB:Q9NS23] synonym: "RDA32" EXACT [UniProtKB:Q9NS23] xref: EMBL:AC002455 xref: EMBL:AC002481 xref: EMBL:AF040703 xref: EMBL:AF061836 xref: EMBL:AF102770 xref: EMBL:AF102771 xref: EMBL:AF102772 xref: EMBL:AF132675 xref: EMBL:AF132676 xref: EMBL:AF132677 xref: EMBL:AF286217 xref: EMBL:AF291719 xref: HGNC:HGNC:9882 xref: UniGene:Hs.476270 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002162 ! RASF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005430 name: RASSF2_human def: "Ras association domain-containing protein 2 gene" [UniProtKB:P50749] synonym: "KIAA0168" EXACT [UniProtKB:P50749] xref: EMBL:AK222650 xref: EMBL:AL133354 xref: EMBL:AY154470 xref: EMBL:AY154472 xref: EMBL:BC117118 xref: EMBL:BC117120 xref: EMBL:CR627436 xref: EMBL:D79990 xref: HGNC:HGNC:9883 xref: UniGene:Hs.631504 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001646 ! RASF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005431 name: RASSF4_human def: "Ras association domain-containing protein 4 gene" [UniProtKB:Q9H2L5] synonym: "AD037" EXACT [UniProtKB:Q9H2L5] xref: EMBL:AF260335 xref: EMBL:AL353801 xref: EMBL:AL713716 xref: EMBL:AY216713 xref: EMBL:AY216714 xref: EMBL:AY216715 xref: EMBL:AY216716 xref: EMBL:BC032593 xref: HGNC:HGNC:20793 xref: UniGene:Hs.522895 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002129 ! RASF4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005432 name: RASSF5_human def: "Ras association domain-containing family protein 5 gene" [UniProtKB:Q8WWW0] synonym: "NORE1" EXACT [UniProtKB:Q8WWW0] synonym: "RAPL" EXACT [UniProtKB:Q8WWW0] xref: EMBL:AF445801 xref: EMBL:AL354681 xref: EMBL:AL591846 xref: EMBL:AL832784 xref: EMBL:AY062002 xref: EMBL:AY062003 xref: EMBL:AY216268 xref: EMBL:AY261332 xref: EMBL:BC004270 xref: EMBL:BC007203 xref: EMBL:BC042651 xref: HGNC:HGNC:17609 xref: UniGene:Hs.497579 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002008 ! RASF5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005433 name: HRAS_human def: "GTPase HRas precursor gene" [UniProtKB:P01112] synonym: "HRAS1" EXACT [UniProtKB:P01112] xref: EMBL:AF493916 xref: EMBL:BC095471 xref: EMBL:BT019421 xref: EMBL:CR536579 xref: EMBL:CR542271 xref: EMBL:J00277 xref: EMBL:M17232 xref: HGNC:HGNC:5173 xref: UniGene:Hs.37003 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001467 ! RASH_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005434 name: KRAS_human def: "GTPase KRas precursor gene" [UniProtKB:P01116] synonym: "KRAS2" EXACT [UniProtKB:P01116] synonym: "RASK2" EXACT [UniProtKB:P01116] xref: EMBL:AF493917 xref: EMBL:BC013572 xref: EMBL:BT007153 xref: EMBL:K01519 xref: EMBL:K01520 xref: EMBL:K03209 xref: EMBL:K03210 xref: EMBL:L00045 xref: EMBL:L00046 xref: EMBL:L00047 xref: EMBL:L00048 xref: EMBL:L00049 xref: EMBL:M25876 xref: EMBL:M30539 xref: EMBL:M34904 xref: EMBL:M54968 xref: EMBL:X01669 xref: EMBL:X02825 xref: HGNC:HGNC:6407 xref: UniGene:Hs.505033 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001468 ! RASK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005436 name: RAB22A_human def: "Ras-related protein Rab-22A gene" [UniProtKB:Q9UL26] synonym: "RAB22" EXACT [UniProtKB:Q9UL26] xref: EMBL:AF091034 xref: EMBL:AF125104 xref: EMBL:AJ276210 xref: EMBL:AL035455 xref: EMBL:BC015710 xref: EMBL:BC063457 xref: EMBL:BT007046 xref: HGNC:HGNC:9764 xref: UniGene:Hs.529044 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005237 ! RB22A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005437 name: RAB27A_human def: "Ras-related protein Rab-27A gene" [UniProtKB:P51159] synonym: "RAB27" EXACT [UniProtKB:P51159] xref: EMBL:AF125393 xref: EMBL:AF154836 xref: EMBL:AF154837 xref: EMBL:AF154838 xref: EMBL:AF154839 xref: EMBL:AF154840 xref: EMBL:AF443871 xref: EMBL:AF498953 xref: EMBL:BC107680 xref: EMBL:CR536496 xref: EMBL:CR541693 xref: EMBL:U38654 xref: EMBL:U57094 xref: HGNC:HGNC:9766 xref: UniGene:Hs.654978 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006223 ! RB27A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005438 name: RBBP4_human def: "Histone-binding protein RBBP4 gene" [UniProtKB:Q09028] synonym: "RBAP48" EXACT [UniProtKB:Q09028] xref: EMBL:AK222779 xref: EMBL:BC003092 xref: EMBL:BC015123 xref: EMBL:BC053904 xref: EMBL:BC075836 xref: EMBL:BT007309 xref: EMBL:X71810 xref: EMBL:X74262 xref: HGNC:HGNC:9887 xref: UniGene:Hs.647652 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001727 ! RBBP4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005439 name: RBBP5_human def: "Retinoblastoma-binding protein 5 gene" [UniProtKB:Q15291] synonym: "RBQ3" EXACT [UniProtKB:Q15291] xref: EMBL:X85134 xref: HGNC:HGNC:9888 xref: UniGene:Hs.519230 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005660 ! RBBP5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005441 name: RBBP7_human def: "Histone-binding protein RBBP7 gene" [UniProtKB:Q16576] synonym: "RBAP46" EXACT [UniProtKB:Q16576] xref: EMBL:U35143 xref: EMBL:X72841 xref: HGNC:HGNC:9890 xref: UniGene:Hs.495755 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005809 ! RBBP7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005442 name: RBBP8_human def: "Retinoblastoma-binding protein 8 gene" [UniProtKB:Q99708] synonym: "CTIP" EXACT [UniProtKB:Q99708] xref: EMBL:AF043431 xref: EMBL:BC030590 xref: EMBL:U72066 xref: HGNC:HGNC:9891 xref: UniGene:Hs.546282 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002084 ! RBBP8_HUMAN relationship: codes_for CCO:B0005289 ! Q8NHQ3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005443 name: RB1CC1_human def: "RB1-inducible coiled-coil protein 1 gene" [UniProtKB:Q8TDY2] synonym: "KIAA0203" EXACT [UniProtKB:Q8TDY2] synonym: "RBICC" EXACT [UniProtKB:Q8TDY2] xref: EMBL:AB059622 xref: EMBL:AC090814 xref: EMBL:AC113139 xref: EMBL:BC017556 xref: EMBL:D86958 xref: HGNC:HGNC:15574 xref: UniGene:Hs.196102 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001995 ! RBCC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005444 name: RABGAP1_human def: "Rab GTPase-activating protein 1 gene" [UniProtKB:Q9Y3P9] synonym: "HSPC094" EXACT [UniProtKB:Q9Y3P9] xref: EMBL:AC007066 xref: EMBL:AF161357 xref: EMBL:AJ011679 xref: EMBL:AK022408 xref: EMBL:AK131449 xref: EMBL:AL050195 xref: EMBL:AL365338 xref: EMBL:BC020609 xref: EMBL:BC054492 xref: HGNC:HGNC:17155 xref: UniGene:Hs.271341 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002254 ! RBGP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005445 name: RBL1_human def: "Retinoblastoma-like protein 1 gene" [UniProtKB:P28749] xref: EMBL:AL136172 xref: EMBL:AL365505 xref: EMBL:AL391114 xref: EMBL:BC032247 xref: EMBL:L14812 xref: EMBL:M74547 xref: EMBL:S78664 xref: HGNC:HGNC:9893 xref: UniGene:Hs.207745 xref: UniGene:Hs.617220 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001567 ! RBL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005446 name: RBL2_human def: "Retinoblastoma-like protein 2 gene" [UniProtKB:Q08999] synonym: "RB2" EXACT [UniProtKB:Q08999] xref: EMBL:S67171 xref: EMBL:U53220 xref: EMBL:X74594 xref: EMBL:X76061 xref: HGNC:HGNC:9894 xref: UniGene:Hs.513609 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001725 ! RBL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005448 name: RBM5_human def: "RNA-binding protein 5 gene" [UniProtKB:P52756] synonym: "H37" EXACT [UniProtKB:P52756] synonym: "LUCA15" EXACT [UniProtKB:P52756] xref: EMBL:AF091263 xref: EMBL:AF103802 xref: EMBL:U23946 xref: EMBL:U73168 xref: HGNC:HGNC:9902 xref: UniGene:Hs.439480 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001660 ! RBM5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005449 name: RBM7_human def: "RNA-binding protein 7 gene" [UniProtKB:Q9Y580] xref: EMBL:AF156098 xref: EMBL:AK002015 xref: EMBL:BC034381 xref: HGNC:HGNC:9904 xref: UniGene:Hs.533736 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002255 ! RBM7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005450 name: RBM8A_human def: "RNA-binding protein 8A gene" [UniProtKB:Q9Y5S9] synonym: "HSPC114" EXACT [UniProtKB:Q9Y5S9] synonym: "MDS014" EXACT [UniProtKB:Q9Y5S9] synonym: "RBM8" EXACT [UniProtKB:Q9Y5S9] xref: EMBL:AF127761 xref: EMBL:AF161463 xref: EMBL:AF182415 xref: EMBL:AF198620 xref: EMBL:AF231511 xref: EMBL:AF231512 xref: EMBL:AF299118 xref: EMBL:AF403012 xref: EMBL:BC017088 xref: EMBL:BC071577 xref: EMBL:CR541805 xref: EMBL:CR541823 xref: HGNC:HGNC:9905 xref: UniGene:Hs.654719 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005223 ! RBM8A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005451 name: RBPMS_human def: "RNA-binding protein with multiple splicing gene" [UniProtKB:Q93062] xref: EMBL:BC003608 xref: EMBL:D84107 xref: EMBL:D84108 xref: EMBL:D84109 xref: EMBL:D84110 xref: EMBL:D84111 xref: HGNC:HGNC:19097 xref: UniGene:Hs.334587 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005178 ! RBPMS_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005452 name: LMO2_human def: "Rhombotin-2 gene" [UniProtKB:P25791] synonym: "RBTN2" EXACT [UniProtKB:P25791] synonym: "RBTNL1" EXACT [UniProtKB:P25791] synonym: "RHOM2" EXACT [UniProtKB:P25791] synonym: "TTG2" EXACT [UniProtKB:P25791] xref: EMBL:AF257211 xref: EMBL:BC034041 xref: EMBL:BC035607 xref: EMBL:BC042426 xref: EMBL:BC073973 xref: EMBL:X61118 xref: HGNC:HGNC:6642 xref: UniGene:Hs.34560 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005171 ! RBTN2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005453 name: RBX1_human def: "RING-box protein 1 gene" [UniProtKB:P62877] synonym: "RNF75" EXACT [UniProtKB:P62877] synonym: "ROC1" EXACT [UniProtKB:P62877] xref: EMBL:AF140598 xref: EMBL:AF142059 xref: EMBL:AL080242 xref: EMBL:AY099360 xref: EMBL:BC001466 xref: EMBL:BC017370 xref: EMBL:CR456560 xref: HGNC:HGNC:9928 xref: UniGene:Hs.474949 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005491 ! RBX1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005454 name: RB1_human def: "Retinoblastoma-associated protein gene" [UniProtKB:P06400] xref: EMBL:AF551763 xref: EMBL:AL136960 xref: EMBL:AL392048 xref: EMBL:BC039060 xref: EMBL:BC040540 xref: EMBL:L11910 xref: EMBL:L35146 xref: EMBL:L35147 xref: EMBL:L41870 xref: EMBL:L41889 xref: EMBL:L41890 xref: EMBL:L41891 xref: EMBL:L41893 xref: EMBL:L41894 xref: EMBL:L41895 xref: EMBL:L41896 xref: EMBL:L41897 xref: EMBL:L41898 xref: EMBL:L41899 xref: EMBL:L41997 xref: EMBL:M15400 xref: EMBL:M27845 xref: EMBL:M27846 xref: EMBL:M27847 xref: EMBL:M27849 xref: EMBL:M27850 xref: EMBL:M27851 xref: EMBL:M27852 xref: EMBL:M27853 xref: EMBL:M27854 xref: EMBL:M27855 xref: EMBL:M27856 xref: EMBL:M27857 xref: EMBL:M27858 xref: EMBL:M27859 xref: EMBL:M27860 xref: EMBL:M27862 xref: EMBL:M27863 xref: EMBL:M27864 xref: EMBL:M27865 xref: EMBL:M27866 xref: EMBL:M28419 xref: EMBL:M33647 xref: EMBL:X16439 xref: HGNC:HGNC:9884 xref: UniGene:Hs.408528 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001491 ! RB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005455 name: RCBTB1_human def: "RCC1 and BTB domain-containing protein 1 gene" [UniProtKB:Q8NDN9] synonym: "CLLD7" EXACT [UniProtKB:Q8NDN9] synonym: "E4.5" EXACT [UniProtKB:Q8NDN9] xref: EMBL:AF334406 xref: EMBL:AJ319660 xref: EMBL:AK096654 xref: EMBL:AL139321 xref: EMBL:AL833821 xref: HGNC:HGNC:18243 xref: UniGene:Hs.508021 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001976 ! RCBT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005456 name: RCC1_human def: "Regulator of chromosome condensation gene" [UniProtKB:P18754] synonym: "CHC1" EXACT [UniProtKB:P18754] xref: EMBL:AF498924 xref: EMBL:BC007300 xref: EMBL:BC010067 xref: EMBL:BC036903 xref: EMBL:D00591 xref: EMBL:X06130 xref: EMBL:X12654 xref: HGNC:HGNC:1913 xref: UniGene:Hs.469723 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001533 ! RCC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005457 name: RCC2_human def: "Protein RCC2 gene" [UniProtKB:Q9P258] synonym: "KIAA1470" EXACT [UniProtKB:Q9P258] synonym: "TD60" EXACT [UniProtKB:Q9P258] xref: EMBL:AB040903 xref: EMBL:AJ421269 xref: EMBL:AL359612 xref: EMBL:BC004933 xref: EMBL:BC042141 xref: EMBL:BC053908 xref: HGNC:HGNC:30297 xref: UniGene:Hs.380857 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002186 ! RCC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005458 name: RCN3_human def: "Reticulocalbin-3 precursor gene" [UniProtKB:Q96D15] synonym: "UNQ239/PRO272" EXACT [UniProtKB:Q96D15] xref: EMBL:AF183423 xref: EMBL:AY195859 xref: EMBL:AY358423 xref: EMBL:BC013436 xref: HGNC:HGNC:21145 xref: UniGene:Hs.567550 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005248 ! RCN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005459 name: REC8_human def: "Meiotic recombination protein REC8 homolog gene" [UniProtKB:O95072] synonym: "REC8L1" EXACT [UniProtKB:O95072] xref: EMBL:AF006264 xref: EMBL:AK001435 xref: EMBL:BC004159 xref: EMBL:BC010887 xref: EMBL:BC019326 xref: EMBL:CR457263 xref: HGNC:HGNC:16879 xref: UniGene:Hs.419259 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001447 ! REC8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005460 name: RECK_human def: "Reversion-inducing cysteine-rich protein with Kazal motifs precursor gene" [UniProtKB:O95980] synonym: "ST15" EXACT [UniProtKB:O95980] xref: EMBL:AL138834 xref: EMBL:AL158830 xref: EMBL:D50406 xref: HGNC:HGNC:11345 xref: UniGene:Hs.388918 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001455 ! RECK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005462 name: RECQL5_human def: "ATP-dependent DNA helicase Q5 gene" [UniProtKB:O94762] synonym: "RECQ5" EXACT [UniProtKB:O94762] xref: EMBL:AB006533 xref: EMBL:AB042823 xref: EMBL:AB042824 xref: EMBL:AB042825 xref: EMBL:AF135183 xref: EMBL:BC016911 xref: HGNC:HGNC:9950 xref: UniGene:Hs.632229 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006224 ! RECQ5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005463 name: IK_human def: "Protein Red gene" [UniProtKB:Q13123] synonym: "RED" EXACT [UniProtKB:Q13123] synonym: "RER" EXACT [UniProtKB:Q13123] xref: EMBL:AJ005579 xref: EMBL:S74221 xref: HGNC:HGNC:5958 xref: UniGene:Hs.421245 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006239 ! RED_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005464 name: RELB_human def: "Transcription factor RelB gene" [UniProtKB:Q01201] xref: EMBL:AF043454 xref: EMBL:AF043455 xref: EMBL:AF043456 xref: EMBL:AF043457 xref: EMBL:AF043458 xref: EMBL:AF043459 xref: EMBL:AF043460 xref: EMBL:AF043461 xref: EMBL:AF043462 xref: EMBL:AF043463 xref: EMBL:BC028013 xref: EMBL:DQ314887 xref: EMBL:M83221 xref: HGNC:HGNC:9956 xref: UniGene:Hs.654402 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005529 ! RELB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005465 name: UPF3A_human def: "Regulator of nonsense transcripts 3A gene" [UniProtKB:Q9H1J1] synonym: "RENT3A" EXACT [UniProtKB:Q9H1J1] synonym: "UPF3" EXACT [UniProtKB:Q9H1J1] xref: EMBL:AF318575 xref: EMBL:AL160396 xref: EMBL:AY013250 xref: EMBL:BC008694 xref: EMBL:BC023569 xref: HGNC:HGNC:20332 xref: UniGene:Hs.533855 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005436 ! REN3A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005466 name: UPF3B_human def: "Regulator of nonsense transcripts 3B gene" [UniProtKB:Q9BZI7] synonym: "RENT3B" EXACT [UniProtKB:Q9BZI7] synonym: "UPF3X" EXACT [UniProtKB:Q9BZI7] xref: EMBL:AF318576 xref: EMBL:AY013251 xref: EMBL:BC121017 xref: HGNC:HGNC:20439 xref: UniGene:Hs.103832 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005434 ! REN3B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005467 name: UPF1_human def: "Regulator of nonsense transcripts 1 gene" [UniProtKB:Q92900] synonym: "KIAA0221" EXACT [UniProtKB:Q92900] synonym: "RENT1" EXACT [UniProtKB:Q92900] xref: EMBL:AC003972 xref: EMBL:AF074016 xref: EMBL:BC039817 xref: EMBL:D86988 xref: EMBL:U59323 xref: EMBL:U65533 xref: HGNC:HGNC:9962 xref: UniGene:Hs.515266 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002024 ! RENT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005468 name: UPF2_human def: "Regulator of nonsense transcripts 2 gene" [UniProtKB:Q9HAU5] synonym: "KIAA1408" EXACT [UniProtKB:Q9HAU5] synonym: "RENT2" EXACT [UniProtKB:Q9HAU5] xref: EMBL:AB037829 xref: EMBL:AC073160 xref: EMBL:AF301013 xref: EMBL:AF318574 xref: EMBL:AK000764 xref: EMBL:AK096191 xref: EMBL:AL080198 xref: EMBL:AL138898 xref: EMBL:AL645617 xref: EMBL:AY013249 xref: EMBL:BC114964 xref: EMBL:BC115737 xref: HGNC:HGNC:17854 xref: UniGene:Hs.370689 xref: UniGene:Hs.610110 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005435 ! RENT2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005469 name: RPA1_human def: "Replication protein A 70 kDa DNA-binding subunit gene" [UniProtKB:P27694] synonym: "REPA1" EXACT [UniProtKB:P27694] synonym: "RPA70" EXACT [UniProtKB:P27694] xref: EMBL:AB209732 xref: EMBL:AY599563 xref: EMBL:BC018126 xref: EMBL:M63488 xref: HGNC:HGNC:10289 xref: UniGene:Hs.461925 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001562 ! RFA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005470 name: RPA2_human def: "Replication protein A 32 kDa subunit gene" [UniProtKB:P15927] synonym: "REPA2" EXACT [UniProtKB:P15927] synonym: "RPA32" EXACT [UniProtKB:P15927] synonym: "RPA34" EXACT [UniProtKB:P15927] xref: EMBL:AL109927 xref: EMBL:BC001630 xref: EMBL:BC012157 xref: EMBL:BC021257 xref: EMBL:CR450348 xref: EMBL:DQ001128 xref: EMBL:J05249 xref: HGNC:HGNC:10290 xref: UniGene:Hs.79411 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005500 ! RFA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005471 name: RPA3_human def: "Replication protein A 14 kDa subunit gene" [UniProtKB:P35244] synonym: "REPA3" EXACT [UniProtKB:P35244] synonym: "RPA14" EXACT [UniProtKB:P35244] xref: EMBL:AC004948 xref: EMBL:BC005264 xref: EMBL:BC009868 xref: EMBL:BT007320 xref: EMBL:DQ003136 xref: EMBL:L07493 xref: HGNC:HGNC:10291 xref: UniGene:Hs.487540 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005501 ! RFA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005472 name: RFC1_human def: "Replication factor C subunit 1 gene" [UniProtKB:P35251] synonym: "RFC140" EXACT [UniProtKB:P35251] xref: EMBL:AF040250 xref: EMBL:AY600371 xref: EMBL:BC035297 xref: EMBL:BC051751 xref: EMBL:BC051786 xref: EMBL:L23320 xref: EMBL:Z22642 xref: HGNC:HGNC:9969 xref: UniGene:Hs.507475 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005887 ! RFC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005473 name: RFC5_human def: "Replication factor C subunit 5 gene" [UniProtKB:P40937] xref: EMBL:AY254323 xref: EMBL:BC001866 xref: EMBL:BC013961 xref: EMBL:L07540 xref: HGNC:HGNC:9973 xref: UniGene:Hs.506989 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006105 ! RFC5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005474 name: RAB11FIP4_human def: "Rab11 family-interacting protein 4 gene" [UniProtKB:Q86YS3] synonym: "KIAA1821" EXACT [UniProtKB:Q86YS3] xref: EMBL:AB058724 xref: EMBL:AJ314646 xref: EMBL:AK097424 xref: EMBL:AL831830 xref: EMBL:AY169244 xref: EMBL:BC093914 xref: EMBL:BC101517 xref: HGNC:HGNC:30267 xref: UniGene:Hs.406788 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005979 ! RFIP4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005475 name: RFWD2_human def: "E3 ubiquitin-protein ligase RFWD2 gene" [UniProtKB:Q8NHY2] synonym: "COP1" EXACT [UniProtKB:Q8NHY2] synonym: "RNF200" EXACT [UniProtKB:Q8NHY2] xref: EMBL:AF508940 xref: EMBL:AK025789 xref: EMBL:AY509921 xref: EMBL:BK000438 xref: HGNC:HGNC:17440 xref: UniGene:Hs.523744 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006001 ! RFWD2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005477 name: RACGAP1_human def: "Rac GTPase-activating protein 1 gene" [UniProtKB:Q9H0H5] synonym: "KIAA1478" EXACT [UniProtKB:Q9H0H5] synonym: "MGCRACGAP" EXACT [UniProtKB:Q9H0H5] xref: EMBL:AB030251 xref: EMBL:AB040911 xref: EMBL:AK000733 xref: EMBL:AL136794 xref: EMBL:BC024144 xref: EMBL:BC032754 xref: EMBL:CR533565 xref: HGNC:HGNC:9804 xref: UniGene:Hs.505469 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002124 ! RGAP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005478 name: RGC32_human def: "Response gene to complement 32 protein gene" [UniProtKB:Q9H4X1] synonym: "C13orf15" EXACT [UniProtKB:Q9H4X1] xref: EMBL:AF036549 xref: EMBL:AL354833 xref: EMBL:BC066334 xref: HGNC:HGNC:20369 xref: UniGene:Hs.507866 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002137 ! RGC32_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005480 name: RGS2_human def: "Regulator of G-protein signaling 2 gene" [UniProtKB:P41220] synonym: "G0S8" EXACT [UniProtKB:P41220] xref: EMBL:AF493926 xref: EMBL:AL035407 xref: EMBL:BC007049 xref: EMBL:BT007065 xref: EMBL:L13391 xref: EMBL:L13463 xref: HGNC:HGNC:9998 xref: UniGene:Hs.78944 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001605 ! RGS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005482 name: ARHGAP18_human def: "Rho GTPase-activating protein 18 gene" [UniProtKB:Q8N392] xref: EMBL:AB053293 xref: EMBL:AL450310 xref: EMBL:AL834511 xref: EMBL:BC017223 xref: EMBL:BC039611 xref: EMBL:BC062417 xref: EMBL:BC101708 xref: EMBL:BC107416 xref: EMBL:BC111940 xref: HGNC:HGNC:21035 xref: UniGene:Hs.486458 xref: UniGene:Hs.669689 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005564 ! RHG18_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005483 name: ARHGAP20_human def: "Rho GTPase-activating protein 20 gene" [UniProtKB:Q9P2F6] synonym: "KIAA1391" EXACT [UniProtKB:Q9P2F6] xref: EMBL:AB037812 xref: EMBL:AY496263 xref: EMBL:AY496264 xref: EMBL:AY496265 xref: EMBL:AY496266 xref: EMBL:AY496267 xref: EMBL:BC039340 xref: HGNC:HGNC:18357 xref: UniGene:Hs.6136 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002188 ! RHG20_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005484 name: RHOB_human def: "Rho-related GTP-binding protein RhoB precursor gene" [UniProtKB:P62745] synonym: "ARH6" EXACT [UniProtKB:P62745] synonym: "ARHB" EXACT [UniProtKB:P62745] xref: EMBL:AC023137 xref: EMBL:AF498971 xref: EMBL:BC066954 xref: EMBL:BK001232 xref: EMBL:BK001671 xref: EMBL:BT019546 xref: EMBL:BT019547 xref: EMBL:CR542272 xref: EMBL:M12174 xref: EMBL:X06820 xref: HGNC:HGNC:668 xref: UniGene:Hs.502876 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001692 ! RHOB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005486 name: RHOXF2_human def: "Rhox homeobox family member 2 gene" [UniProtKB:Q9BQY4] synonym: "PEPP2" EXACT [UniProtKB:Q9BQY4] synonym: "THG1" EXACT [UniProtKB:Q9BQY4] xref: EMBL:AF317219 xref: EMBL:AK058125 xref: EMBL:AL590524 xref: EMBL:AL590526 xref: EMBL:BC021719 xref: HGNC:HGNC:30011 xref: UniGene:Hs.196956 xref: UniGene:Hs.567620 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005274 ! RHXF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005487 name: RPN1_human def: "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor gene" [UniProtKB:P04843] xref: EMBL:BC010839 xref: EMBL:CR749284 xref: EMBL:Y00281 xref: HGNC:HGNC:10381 xref: UniGene:Hs.518244 xref: UniGene:Hs.603636 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0040688 ! RPN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005488 name: RIBC2_human def: "RIB43A-like with coiled-coils protein 2 gene" [UniProtKB:Q9H4K1] synonym: "C22orf11" EXACT [UniProtKB:Q9H4K1] xref: EMBL:AL021391 xref: EMBL:AL050075 xref: EMBL:AL442116 xref: EMBL:BC003024 xref: EMBL:BC009904 xref: EMBL:CR456438 xref: EMBL:CR457398 xref: HGNC:HGNC:13241 xref: UniGene:Hs.475110 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005240 ! RIBC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005489 name: RIF1_human def: "Telomere-associated protein RIF1 gene" [UniProtKB:Q5UIP0] xref: EMBL:AC009497 xref: EMBL:AK001461 xref: EMBL:AK022932 xref: EMBL:AK024033 xref: EMBL:AK074349 xref: EMBL:AL080129 xref: EMBL:AY584066 xref: EMBL:AY585745 xref: EMBL:AY727910 xref: EMBL:AY727911 xref: EMBL:AY727912 xref: EMBL:AY727913 xref: EMBL:CR933663 xref: EMBL:U79263 xref: HGNC:HGNC:23207 xref: UniGene:Hs.655671 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001897 ! RIF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005490 name: RIN1_human def: "Ras and Rab interactor 1 gene" [UniProtKB:Q13671] xref: EMBL:BC014417 xref: EMBL:L36463 xref: HGNC:HGNC:18749 xref: UniGene:Hs.1030 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005385 ! RIN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005491 name: RINT1_human def: "RAD50-interacting protein 1 gene" [UniProtKB:Q6NUQ1] xref: EMBL:AC073073 xref: EMBL:AF317622 xref: EMBL:AK021847 xref: EMBL:BC007120 xref: EMBL:BC068483 xref: HGNC:HGNC:21876 xref: UniGene:Hs.592270 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001909 ! RINT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005493 name: RIPK2_human def: "Receptor-interacting serine/threonine-protein kinase 2 gene" [UniProtKB:O43353] synonym: "CARDIAK" EXACT [UniProtKB:O43353] synonym: "RICK" EXACT [UniProtKB:O43353] synonym: "RIP2" EXACT [UniProtKB:O43353] synonym: "UNQ277/PRO314/PRO34092" EXACT [UniProtKB:O43353] xref: EMBL:AC004003 xref: EMBL:AF027706 xref: EMBL:AF064824 xref: EMBL:AF078530 xref: EMBL:AF117829 xref: EMBL:AY358813 xref: EMBL:AY358814 xref: EMBL:BC004553 xref: HGNC:HGNC:10020 xref: UniGene:Hs.103755 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005216 ! RIPK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005494 name: RRM1_human def: "Ribonucleoside-diphosphate reductase large subunit gene" [UniProtKB:P23921] synonym: "RR1" EXACT [UniProtKB:P23921] xref: EMBL:AF107045 xref: EMBL:BC006498 xref: EMBL:L10342 xref: EMBL:X59543 xref: EMBL:X59617 xref: HGNC:HGNC:10451 xref: UniGene:Hs.558393 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006232 ! RIR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005495 name: RIT1_human def: "GTP-binding protein Rit1 gene" [UniProtKB:Q92963] synonym: "RIBB" EXACT [UniProtKB:Q92963] synonym: "RIT" EXACT [UniProtKB:Q92963] synonym: "ROC1" EXACT [UniProtKB:Q92963] xref: EMBL:AF084462 xref: EMBL:AF493923 xref: EMBL:U71203 xref: EMBL:U78165 xref: EMBL:Y07566 xref: HGNC:HGNC:10023 xref: UniGene:Hs.491234 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006229 ! RIT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005496 name: RPL11_human def: "60S ribosomal protein L11 gene" [UniProtKB:P62913] xref: EMBL:AB007171 xref: EMBL:AF101385 xref: EMBL:AF432212 xref: EMBL:BC018970 xref: EMBL:L05092 xref: EMBL:X79234 xref: HGNC:HGNC:10301 xref: UniGene:Hs.388664 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005858 ! RL11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005497 name: RPL12_human def: "60S ribosomal protein L12 gene" [UniProtKB:P30050] xref: EMBL:AL445222 xref: EMBL:BC050644 xref: EMBL:BC094831 xref: EMBL:BC105603 xref: EMBL:L06505 xref: HGNC:HGNC:10302 xref: UniGene:Hs.408054 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005855 ! RL12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005498 name: RPL15_human def: "60S ribosomal protein L15 gene" [UniProtKB:P61313] synonym: "EC45" EXACT [UniProtKB:P61313] synonym: "TCBAP0781" EXACT [UniProtKB:P61313] xref: EMBL:AB061823 xref: EMBL:AF279903 xref: EMBL:AF283772 xref: EMBL:AY347528 xref: EMBL:BC014837 xref: EMBL:BC068198 xref: EMBL:BC070328 xref: EMBL:BC071672 xref: EMBL:L25899 xref: HGNC:HGNC:10306 xref: UniGene:Hs.381219 xref: UniGene:Hs.695621 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005857 ! RL15_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005500 name: RPL18_human def: "60S ribosomal protein L18 gene" [UniProtKB:Q07020] xref: EMBL:AB061825 xref: EMBL:BC000374 xref: EMBL:BC009708 xref: EMBL:BC021743 xref: EMBL:L11566 xref: HGNC:HGNC:10310 xref: UniGene:Hs.515517 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005741 ! RL18_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005501 name: RPL21_human def: "60S ribosomal protein L21 gene" [UniProtKB:P46778] xref: EMBL:AB007176 xref: EMBL:AB061826 xref: EMBL:BC001603 xref: EMBL:BC007505 xref: EMBL:BC062981 xref: EMBL:BC070184 xref: EMBL:BC070323 xref: EMBL:BC070330 xref: EMBL:L38826 xref: EMBL:U14967 xref: EMBL:U25789 xref: EMBL:X89401 xref: HGNC:HGNC:10313 xref: UniGene:Hs.381123 xref: UniGene:Hs.702965 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005862 ! RL21_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005502 name: RPL22_human def: "60S ribosomal protein L22 gene" [UniProtKB:P35268] xref: EMBL:AL031847 xref: EMBL:BC035566 xref: EMBL:BC058887 xref: EMBL:BC066314 xref: EMBL:CH471130 xref: EMBL:CR456873 xref: EMBL:D17652 xref: EMBL:X59357 xref: HGNC:HGNC:10315 xref: UniGene:Hs.515329 xref: UniGene:Hs.554762 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005751 ! RL22_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005503 name: RPL24_human def: "60S ribosomal protein L24 gene" [UniProtKB:P83731] xref: EMBL:AB007177 xref: EMBL:AB061828 xref: EMBL:BC000690 xref: EMBL:BC070193 xref: EMBL:CR456729 xref: EMBL:M94314 xref: HGNC:HGNC:10325 xref: UniGene:Hs.477028 xref: UniGene:Hs.649475 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005856 ! RL24_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005504 name: RPL27_human def: "60S ribosomal protein L27 gene" [UniProtKB:P61353] xref: EMBL:AB061851 xref: EMBL:BC001700 xref: EMBL:BC002588 xref: EMBL:BC007273 xref: EMBL:BC010026 xref: EMBL:BC098560 xref: EMBL:L05094 xref: EMBL:L19527 xref: HGNC:HGNC:10328 xref: UniGene:Hs.514196 xref: UniGene:Hs.660076 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005859 ! RL27_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005505 name: RPL28_human def: "60S ribosomal protein L28 gene" [UniProtKB:P46779] xref: EMBL:BC010173 xref: EMBL:BC010182 xref: EMBL:BC011582 xref: EMBL:CR457024 xref: EMBL:U14969 xref: HGNC:HGNC:10330 xref: UniGene:Hs.652114 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005853 ! RL28_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005506 name: RPL37A_human def: "60S ribosomal protein L37a gene" [UniProtKB:P61513] xref: EMBL:BC000555 xref: EMBL:BC014262 xref: EMBL:BC016748 xref: EMBL:BC082239 xref: EMBL:L06499 xref: EMBL:L22154 xref: EMBL:X66699 xref: HGNC:HGNC:10348 xref: UniGene:Hs.433701 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006231 ! RL37A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005507 name: RPL4_human def: "60S ribosomal protein L4 gene" [UniProtKB:P36578] synonym: "RPL1" EXACT [UniProtKB:P36578] xref: EMBL:AB061820 xref: EMBL:BC001365 xref: EMBL:BC005817 xref: EMBL:BC007748 xref: EMBL:BC007996 xref: EMBL:BC009888 xref: EMBL:BC010151 xref: EMBL:BC014653 xref: EMBL:BC066925 xref: EMBL:BC095427 xref: EMBL:D23660 xref: EMBL:L20868 xref: HGNC:HGNC:10353 xref: UniGene:Hs.186350 xref: UniGene:Hs.644628 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005861 ! RL4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005508 name: RPL7A_human def: "60S ribosomal protein L7a gene" [UniProtKB:P62424] synonym: "SURF-3" EXACT [UniProtKB:P62424] synonym: "SURF3" EXACT [UniProtKB:P62424] xref: EMBL:BC005128 xref: EMBL:BC021979 xref: EMBL:BC023594 xref: EMBL:BC023624 xref: EMBL:BC071900 xref: EMBL:BC071901 xref: EMBL:BC073802 xref: EMBL:M36072 xref: EMBL:X06705 xref: EMBL:X52138 xref: EMBL:X61923 xref: HGNC:HGNC:10364 xref: UniGene:Hs.499839 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005761 ! RL7A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005509 name: RPL7_human def: "60S ribosomal protein L7 gene" [UniProtKB:P18124] xref: EMBL:BC006095 xref: EMBL:BC008850 xref: EMBL:BC009599 xref: EMBL:BC071671 xref: EMBL:BC071894 xref: EMBL:BC071895 xref: EMBL:BC087837 xref: EMBL:CR456773 xref: EMBL:L16558 xref: EMBL:X52967 xref: EMBL:X57958 xref: EMBL:X57959 xref: HGNC:HGNC:10363 xref: UniGene:Hs.421257 xref: UniGene:Hs.571841 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005746 ! RL7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005510 name: RPL8_human def: "60S ribosomal protein L8 gene" [UniProtKB:P62917] xref: EMBL:AB007168 xref: EMBL:AB061821 xref: EMBL:BC000047 xref: EMBL:BC000077 xref: EMBL:BC012197 xref: EMBL:BC013104 xref: EMBL:BC093064 xref: EMBL:BT007379 xref: EMBL:CR457046 xref: EMBL:Z28407 xref: HGNC:HGNC:10368 xref: UniGene:Hs.178551 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005860 ! RL8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005511 name: RPLP0_human def: "60S acidic ribosomal protein P0 gene" [UniProtKB:P05388] xref: EMBL:AB007187 xref: EMBL:AC004263 xref: EMBL:BC000087 xref: EMBL:BC000345 xref: EMBL:BC000752 xref: EMBL:BC001127 xref: EMBL:BC001834 xref: EMBL:BC003655 xref: EMBL:BC005863 xref: EMBL:BC008092 xref: EMBL:BC008594 xref: EMBL:BC009867 xref: EMBL:BC015173 xref: EMBL:BC015690 xref: EMBL:M17885 xref: HGNC:HGNC:10371 xref: UniGene:Hs.546285 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005762 ! RLA0_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005512 name: RPLP1_human def: "60S acidic ribosomal protein P1 gene" [UniProtKB:P05386] synonym: "RRP1" EXACT [UniProtKB:P05386] xref: EMBL:AB061836 xref: EMBL:BC003369 xref: EMBL:BC007590 xref: EMBL:M17886 xref: HGNC:HGNC:10372 xref: UniGene:Hs.356502 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005770 ! RLA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005513 name: RPLP2_human def: "60S acidic ribosomal protein P2 gene" [UniProtKB:P05387] synonym: "D11S2243E" EXACT [UniProtKB:P05387] synonym: "RPP2" EXACT [UniProtKB:P05387] xref: EMBL:AB061837 xref: EMBL:BC005354 xref: EMBL:BC005920 xref: EMBL:BC007573 xref: EMBL:BC062314 xref: EMBL:M17887 xref: HGNC:HGNC:10377 xref: UniGene:Hs.437594 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005864 ! RLA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005514 name: MRPL20_human def: "39S ribosomal protein L20, mitochondrial precursor gene" [UniProtKB:Q9BYC9] xref: EMBL:AB049644 xref: EMBL:AL391244 xref: EMBL:BC009515 xref: EMBL:BC014316 xref: EMBL:BC059945 xref: HGNC:HGNC:14478 xref: UniGene:Hs.182698 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006248 ! RM20_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005515 name: MRPL41_human def: "39S ribosomal protein L41, mitochondrial precursor gene" [UniProtKB:Q8IXM3] synonym: "BMRP" EXACT [UniProtKB:Q8IXM3] synonym: "PIG3" EXACT [UniProtKB:Q8IXM3] synonym: "RPML27" EXACT [UniProtKB:Q8IXM3] xref: EMBL:AB051625 xref: EMBL:AL365502 xref: EMBL:AY232291 xref: EMBL:BC040035 xref: HGNC:HGNC:14492 xref: UniGene:Hs.44017 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001952 ! RM41_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005516 name: RMI1_human def: "Protein RMI1 homolog gene" [UniProtKB:Q9H9A7] synonym: "C9orf76" EXACT [UniProtKB:Q9H9A7] xref: EMBL:AK022950 xref: EMBL:AL732446 xref: EMBL:BC039999 xref: EMBL:BC053549 xref: EMBL:BC064937 xref: HGNC:HGNC:25764 xref: UniGene:Hs.284137 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005919 ! RMI1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005518 name: RNASEN_human def: "Ribonuclease 3 gene" [UniProtKB:Q9NRR4] synonym: "RN3" EXACT [UniProtKB:Q9NRR4] synonym: "RNASE3L" EXACT [UniProtKB:Q9NRR4] xref: EMBL:AF116910 xref: EMBL:AF189011 xref: EMBL:AJ242976 xref: EMBL:AK001121 xref: EMBL:BC041162 xref: EMBL:BC054003 xref: HGNC:HGNC:17904 xref: UniGene:Hs.97997 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006026 ! RNC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005519 name: RNF10_human def: "RING finger protein 10 gene" [UniProtKB:Q8N5U6] synonym: "KIAA0262" EXACT [UniProtKB:Q8N5U6] synonym: "RIE2" EXACT [UniProtKB:Q8N5U6] xref: EMBL:AB027196 xref: EMBL:AL389976 xref: EMBL:BC016622 xref: EMBL:BC031596 xref: EMBL:BC101709 xref: EMBL:BC101715 xref: EMBL:BT006974 xref: EMBL:D87451 xref: HGNC:HGNC:10055 xref: UniGene:Hs.442798 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006230 ! RNF10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005520 name: RNF31_human def: "RING finger protein 31 gene" [UniProtKB:Q96EP0] synonym: "ZIBRA" EXACT [UniProtKB:Q96EP0] xref: EMBL:AK000973 xref: EMBL:AK027154 xref: EMBL:AK055542 xref: EMBL:AK074144 xref: EMBL:AY256461 xref: EMBL:BC009821 xref: EMBL:BC012077 xref: EMBL:BC017376 xref: HGNC:HGNC:16031 xref: UniGene:Hs.375217 xref: UniGene:Hs.434081 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005982 ! RNF31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005521 name: UBOX5_human def: "RING finger protein 37 gene" [UniProtKB:O94941] synonym: "KIAA0860" EXACT [UniProtKB:O94941] synonym: "RNF37" EXACT [UniProtKB:O94941] synonym: "UBCE7IP5" EXACT [UniProtKB:O94941] xref: EMBL:AB020667 xref: EMBL:AL121891 xref: EMBL:BC000515 xref: HGNC:HGNC:17777 xref: UniGene:Hs.654646 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005309 ! RNF37_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005524 name: ZNRD1_human def: "DNA-directed RNA polymerase I subunit RPA12 gene" [UniProtKB:Q9P1U0] synonym: "RPA12" EXACT [UniProtKB:Q9P1U0] xref: EMBL:AF024617 xref: EMBL:AF230337 xref: EMBL:AF230338 xref: EMBL:AL669914 xref: EMBL:AL671859 xref: EMBL:AL845439 xref: EMBL:BC010898 xref: EMBL:BC050608 xref: EMBL:BX088647 xref: EMBL:CR457109 xref: HGNC:HGNC:13182 xref: UniGene:Hs.57813 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005622 ! RPA12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005525 name: POLR1C_human def: "DNA-directed RNA polymerases I and III subunit RPAC1 gene" [UniProtKB:O15160] synonym: "POLR1E" EXACT [UniProtKB:O15160] xref: EMBL:AF008442 xref: EMBL:AF047441 xref: EMBL:AL355802 xref: EMBL:BC008863 xref: HGNC:HGNC:20194 xref: UniGene:Hs.584839 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005246 ! RPAC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005526 name: POLR2C_human def: "DNA-directed RNA polymerase II subunit RPB3 gene" [UniProtKB:P19387] synonym: "A-152E5.7" EXACT [UniProtKB:P19387] xref: EMBL:AC004382 xref: EMBL:AF008443 xref: EMBL:AJ224143 xref: EMBL:AJ224144 xref: EMBL:BC000409 xref: EMBL:BC003159 xref: EMBL:BC028157 xref: EMBL:J05448 xref: HGNC:HGNC:9189 xref: UniGene:Hs.79402 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006100 ! RPB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005528 name: POLR3F_human def: "DNA-directed RNA polymerase III subunit RPC6 gene" [UniProtKB:Q9H1D9] xref: EMBL:AL121893 xref: EMBL:BC012588 xref: EMBL:U93869 xref: HGNC:HGNC:15763 xref: UniGene:Hs.472227 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006101 ! RPC6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005529 name: RPS10_human def: "40S ribosomal protein S10 gene" [UniProtKB:P46783] xref: EMBL:AB007151 xref: EMBL:BC001032 xref: EMBL:BC001955 xref: EMBL:BC005012 xref: EMBL:BC070235 xref: EMBL:BC071946 xref: EMBL:BC073799 xref: EMBL:BX255972 xref: EMBL:U14972 xref: HGNC:HGNC:10383 xref: UniGene:Hs.645317 xref: UniGene:Hs.702925 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005749 ! RS10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005530 name: RPS12_human def: "40S ribosomal protein S12 gene" [UniProtKB:P25398] xref: EMBL:AB007153 xref: EMBL:X53505 xref: HGNC:HGNC:10385 xref: UniGene:Hs.546289 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005767 ! RS12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005531 name: RPS13_human def: "40S ribosomal protein S13 gene" [UniProtKB:P62277] xref: EMBL:BC000475 xref: EMBL:BC006772 xref: EMBL:BC029732 xref: EMBL:BC066322 xref: EMBL:BC100032 xref: EMBL:D88010 xref: EMBL:L01124 xref: EMBL:L05090 xref: EMBL:X79239 xref: HGNC:HGNC:10386 xref: UniGene:Hs.446588 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005748 ! RS13_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005532 name: RPS18_human def: "40S ribosomal protein S18 gene" [UniProtKB:P62269] synonym: "D6S218E" EXACT [UniProtKB:P62269] xref: EMBL:AL031228 xref: EMBL:X69150 xref: HGNC:HGNC:10401 xref: UniGene:Hs.627414 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005763 ! RS18_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005533 name: RPS19_human def: "40S ribosomal protein S19 gene" [UniProtKB:P39019] xref: EMBL:AB007155 xref: EMBL:AF092906 xref: EMBL:AF092907 xref: EMBL:BC000023 xref: EMBL:BC007615 xref: EMBL:BC018616 xref: EMBL:M81757 xref: HGNC:HGNC:10402 xref: UniGene:Hs.438429 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005744 ! RS19_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005534 name: RPS20_human def: "40S ribosomal protein S20 gene" [UniProtKB:P60866] xref: EMBL:AB007156 xref: EMBL:AB061842 xref: EMBL:BC007507 xref: EMBL:BC087850 xref: EMBL:L06498 xref: HGNC:HGNC:10405 xref: UniGene:Hs.8102 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005563 ! RS20_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005535 name: RPS24_human def: "40S ribosomal protein S24 gene" [UniProtKB:P62847] xref: EMBL:BC000523 xref: EMBL:BC003149 xref: EMBL:BC071926 xref: EMBL:M31520 xref: EMBL:U12202 xref: HGNC:HGNC:10411 xref: UniGene:Hs.356794 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005726 ! RS24_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005536 name: RPS3A_human def: "40S ribosomal protein S3a gene" [UniProtKB:P61247] synonym: "MFTL" EXACT [UniProtKB:P61247] xref: EMBL:AB007148 xref: EMBL:BC000204 xref: EMBL:BC001708 xref: EMBL:BC004981 xref: EMBL:BC006298 xref: EMBL:BC009219 xref: EMBL:BC009404 xref: EMBL:BC017123 xref: EMBL:BC019072 xref: EMBL:BC030161 xref: EMBL:BC070211 xref: EMBL:BC071916 xref: EMBL:L13802 xref: EMBL:M77234 xref: EMBL:M84711 xref: EMBL:X87373 xref: HGNC:HGNC:10421 xref: UniGene:Hs.356572 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005768 ! RS3A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005537 name: RPS4X_human def: "40S ribosomal protein S4, X isoform gene" [UniProtKB:P62701] synonym: "CCG2" EXACT [UniProtKB:P62701] synonym: "RPS4" EXACT [UniProtKB:P62701] synonym: "SCAR" EXACT [UniProtKB:P62701] xref: EMBL:AF041428 xref: EMBL:BC000472 xref: EMBL:BC071662 xref: EMBL:BC100903 xref: EMBL:BC100904 xref: EMBL:CR456735 xref: EMBL:M22146 xref: EMBL:M58458 xref: EMBL:Z70767 xref: HGNC:HGNC:10424 xref: UniGene:Hs.446628 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001691 ! RS4X_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005538 name: RPS7_human def: "40S ribosomal protein S7 gene" [UniProtKB:P62081] xref: EMBL:BC002866 xref: EMBL:BC061901 xref: EMBL:BC071919 xref: EMBL:M77233 xref: EMBL:Z25749 xref: HGNC:HGNC:10440 xref: UniGene:Hs.534346 xref: UniGene:Hs.546287 xref: UniGene:Hs.646582 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005758 ! RS7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005539 name: RPS8_human def: "40S ribosomal protein S8 gene" [UniProtKB:P62241] synonym: "OK/SW-cl.83" EXACT [UniProtKB:P62241] xref: EMBL:AB062401 xref: EMBL:BC070875 xref: EMBL:X67247 xref: HGNC:HGNC:10441 xref: UniGene:Hs.512675 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005734 ! RS8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005540 name: RPS9_human def: "40S ribosomal protein S9 gene" [UniProtKB:P46781] xref: EMBL:AB007150 xref: EMBL:AB061839 xref: EMBL:BC000802 xref: EMBL:BC007410 xref: EMBL:BC007434 xref: EMBL:BC007857 xref: EMBL:BC068055 xref: EMBL:BC071940 xref: EMBL:BC096756 xref: EMBL:U14971 xref: HGNC:HGNC:10442 xref: UniGene:Hs.467284 xref: UniGene:Hs.546288 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005750 ! RS9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005541 name: SNRPN_human def: "Small nuclear ribonucleoprotein-associated protein N gene" [UniProtKB:P63162] synonym: "HCERN3" EXACT [UniProtKB:P63162] synonym: "SMN" EXACT [UniProtKB:P63162] xref: EMBL:AF400432 xref: EMBL:BC000611 xref: EMBL:BC003180 xref: EMBL:BC024777 xref: EMBL:BC025178 xref: EMBL:CR450350 xref: EMBL:J04615 xref: EMBL:U41303 xref: EMBL:X15892 xref: HGNC:HGNC:11164 xref: UniGene:Hs.555970 xref: UniGene:Hs.564847 xref: UniGene:Hs.578619 xref: UniGene:Hs.585703 xref: UniGene:Hs.621316 xref: UniGene:Hs.632166 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006111 ! RSMN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005542 name: RSPH1_human def: "Radial spoke head 1 homolog gene" [UniProtKB:Q8WYR4] synonym: "TSA2" EXACT [UniProtKB:Q8WYR4] synonym: "TSGA2" EXACT [UniProtKB:Q8WYR4] xref: EMBL:AB006536 xref: EMBL:AB041016 xref: EMBL:BC101519 xref: EMBL:BC113367 xref: HGNC:HGNC:12371 xref: UniGene:Hs.661069 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002012 ! RSPH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005543 name: RPSA_human def: "40S ribosomal protein SA gene" [UniProtKB:P08865] synonym: "LAMBR" EXACT [UniProtKB:P08865] synonym: "LAMR1" EXACT [UniProtKB:P08865] xref: EMBL:AB007146 xref: EMBL:AF503367 xref: EMBL:BC005391 xref: EMBL:BC008867 xref: EMBL:BC010418 xref: EMBL:BC013827 xref: EMBL:BC034537 xref: EMBL:BC050688 xref: EMBL:BC053370 xref: EMBL:BC062714 xref: EMBL:BC066941 xref: EMBL:BC068062 xref: EMBL:BC070263 xref: EMBL:BC071693 xref: EMBL:BC071968 xref: EMBL:BC071969 xref: EMBL:BC071970 xref: EMBL:BC071971 xref: EMBL:BC073863 xref: EMBL:BC107567 xref: EMBL:BT007219 xref: EMBL:J03799 xref: EMBL:M14199 xref: EMBL:S37431 xref: EMBL:U36484 xref: EMBL:U43901 xref: EMBL:X15005 xref: EMBL:X61156 xref: HGNC:HGNC:6502 xref: UniGene:Hs.449909 xref: UniGene:Hs.560655 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005776 ! RSSA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005544 name: MRPS6_human def: "Mitochondrial 28S ribosomal protein S6 gene" [UniProtKB:P82932] synonym: "C21orf101" EXACT [UniProtKB:P82932] synonym: "RPMS6" EXACT [UniProtKB:P82932] xref: EMBL:AB049942 xref: EMBL:AB051347 xref: EMBL:AP001719 xref: EMBL:AY061855 xref: EMBL:BC000547 xref: EMBL:BC004976 xref: EMBL:BC010076 xref: EMBL:BC051302 xref: HGNC:HGNC:14051 xref: UniGene:Hs.302742 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006208 ! RT06_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005545 name: MRPS12_human def: "28S ribosomal protein S12, mitochondrial precursor gene" [UniProtKB:O15235] synonym: "RPMS12" EXACT [UniProtKB:O15235] synonym: "RPSM12" EXACT [UniProtKB:O15235] xref: EMBL:AF058761 xref: EMBL:BC001617 xref: EMBL:BC006424 xref: EMBL:BC007499 xref: EMBL:Y11681 xref: HGNC:HGNC:10380 xref: UniGene:Hs.411125 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006095 ! RT12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005547 name: RUNX3_human def: "Runt-related transcription factor 3 gene" [UniProtKB:Q13761] synonym: "AML2" EXACT [UniProtKB:Q13761] synonym: "CBFA3" EXACT [UniProtKB:Q13761] synonym: "PEBP2A3" EXACT [UniProtKB:Q13761] xref: EMBL:AL023096 xref: EMBL:BC013362 xref: EMBL:U14520 xref: EMBL:X79550 xref: EMBL:Z35278 xref: HGNC:HGNC:10473 xref: UniGene:Hs.170019 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001766 ! RUNX3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005548 name: RUVBL1_human def: "RuvB-like 1 gene" [UniProtKB:Q9Y265] synonym: "NMP238" EXACT [UniProtKB:Q9Y265] synonym: "TIP49" EXACT [UniProtKB:Q9Y265] synonym: "TIP49A" EXACT [UniProtKB:Q9Y265] xref: EMBL:AB012122 xref: EMBL:AF070735 xref: EMBL:AF099084 xref: EMBL:AF380343 xref: EMBL:AF380344 xref: EMBL:AJ010058 xref: EMBL:AK222563 xref: EMBL:AK222575 xref: EMBL:BC002993 xref: EMBL:BC012886 xref: EMBL:BT007057 xref: EMBL:DQ469310 xref: EMBL:Y18418 xref: HGNC:HGNC:10474 xref: UniGene:Hs.272822 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002249 ! RUVB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005549 name: RUVBL2_human def: "RuvB-like 2 gene" [UniProtKB:Q9Y230] synonym: "CGI-46" EXACT [UniProtKB:Q9Y230] synonym: "TIP48" EXACT [UniProtKB:Q9Y230] synonym: "TIP49B" EXACT [UniProtKB:Q9Y230] xref: EMBL:AB024301 xref: EMBL:AF124607 xref: EMBL:AF151804 xref: EMBL:AF155138 xref: EMBL:AK074542 xref: EMBL:AL136743 xref: EMBL:BC000428 xref: EMBL:BC004531 xref: EMBL:BC008355 xref: EMBL:CR533507 xref: EMBL:Y18417 xref: HGNC:HGNC:10475 xref: UniGene:Hs.515846 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005364 ! RUVB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005550 name: SNRPG_human def: "Small nuclear ribonucleoprotein G gene" [UniProtKB:P62308] synonym: "PBSCG" EXACT [UniProtKB:P62308] xref: EMBL:BC000070 xref: EMBL:BC022432 xref: EMBL:BC066302 xref: EMBL:BC070166 xref: EMBL:X85373 xref: HGNC:HGNC:11163 xref: UniGene:Hs.465167 xref: UniGene:Hs.516076 xref: UniGene:Hs.631639 xref: UniGene:Hs.654528 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005495 ! RUXG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005551 name: S100B_human def: "Protein S100-B gene" [UniProtKB:P04271] xref: EMBL:AP000339 xref: EMBL:BC001766 xref: EMBL:CR542123 xref: EMBL:M59487 xref: EMBL:M59488 xref: HGNC:HGNC:10500 xref: UniGene:Hs.422181 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005378 ! S100B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005552 name: S100A6_human def: "Protein S100-A6 gene" [UniProtKB:P06703] synonym: "CACY" EXACT [UniProtKB:P06703] xref: EMBL:AY034480 xref: EMBL:BC001431 xref: EMBL:BC009017 xref: EMBL:BT006965 xref: EMBL:BX470102 xref: EMBL:J02763 xref: EMBL:M14300 xref: EMBL:M18981 xref: HGNC:HGNC:10496 xref: UniGene:Hs.275243 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001494 ! S10A6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005553 name: S100A8_human def: "Protein S100-A8 gene" [UniProtKB:P05109] synonym: "CAGA" EXACT [UniProtKB:P05109] synonym: "CFAG" EXACT [UniProtKB:P05109] synonym: "MRP8" EXACT [UniProtKB:P05109] xref: EMBL:AL591704 xref: EMBL:BC005928 xref: EMBL:BT007378 xref: EMBL:CR407674 xref: EMBL:M21005 xref: EMBL:X06234 xref: EMBL:Y00278 xref: HGNC:HGNC:10498 xref: UniGene:Hs.416073 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006159 ! S10A8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005554 name: S100A9_human def: "Protein S100-A9 gene" [UniProtKB:P06702] synonym: "CAGB" EXACT [UniProtKB:P06702] synonym: "CFAG" EXACT [UniProtKB:P06702] synonym: "MRP14" EXACT [UniProtKB:P06702] xref: EMBL:AF237581 xref: EMBL:AF237582 xref: EMBL:AL591704 xref: EMBL:BC047681 xref: EMBL:CR542207 xref: EMBL:CR542224 xref: EMBL:M21064 xref: EMBL:M26311 xref: EMBL:X06233 xref: HGNC:HGNC:10499 xref: UniGene:Hs.112405 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005461 ! S10A9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005555 name: S100A11_human def: "Protein S100-A11 gene" [UniProtKB:P31949] synonym: "MLN70" EXACT [UniProtKB:P31949] synonym: "S100C" EXACT [UniProtKB:P31949] xref: EMBL:AL591893 xref: EMBL:BC001410 xref: EMBL:BC014354 xref: EMBL:BT009912 xref: EMBL:D38583 xref: EMBL:D49355 xref: EMBL:D50374 xref: EMBL:X80201 xref: HGNC:HGNC:10488 xref: UniGene:Hs.417004 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005825 ! S10AB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005557 name: SNAPAP_human def: "SNARE-associated protein Snapin gene" [UniProtKB:O95295] synonym: "SNAP25BP" EXACT [UniProtKB:O95295] xref: EMBL:AF086837 xref: EMBL:AK024555 xref: EMBL:BC000761 xref: EMBL:BC004494 xref: EMBL:BT006753 xref: HGNC:HGNC:17145 xref: UniGene:Hs.32018 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006234 ! S25BP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005558 name: SAC3D1_human def: "SAC3 domain-containing protein 1 gene" [UniProtKB:A6NKF1] synonym: "SHD1" EXACT [UniProtKB:A6NKF1] xref: EMBL:AP003068 xref: EMBL:BC007448 xref: HGNC:HGNC:30179 xref: UniGene:Hs.23642 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001334 ! SAC31_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005560 name: SAE1_human def: "SUMO-activating enzyme subunit 1 gene" [UniProtKB:Q9UBE0] synonym: "AOS1" EXACT [UniProtKB:Q9UBE0] synonym: "SUA1" EXACT [UniProtKB:Q9UBE0] synonym: "UBLE1A" EXACT [UniProtKB:Q9UBE0] xref: EMBL:AF046025 xref: EMBL:AF090385 xref: EMBL:AF110956 xref: EMBL:AF161489 xref: EMBL:BC000344 xref: EMBL:BC003611 xref: EMBL:BC018271 xref: EMBL:BT007290 xref: HGNC:HGNC:30660 xref: UniGene:Hs.515500 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006046 ! SAE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005561 name: SAMD3_human def: "Sterile alpha motif domain-containing protein 3 gene" [UniProtKB:Q8N6K7] xref: EMBL:AK091351 xref: EMBL:AK091882 xref: EMBL:AL355581 xref: EMBL:BC029851 xref: EMBL:BC119757 xref: EMBL:BC119758 xref: HGNC:HGNC:21574 xref: UniGene:Hs.440508 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005257 ! SAMD3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005564 name: SASS6_human def: "Spindle assembly abnormal protein 6 homolog gene" [UniProtKB:Q6UVJ0] synonym: "SAS6" EXACT [UniProtKB:Q6UVJ0] xref: EMBL:AC093019 xref: EMBL:AL445928 xref: EMBL:AL834265 xref: EMBL:AY359522 xref: HGNC:HGNC:25403 xref: UniGene:Hs.591447 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001918 ! SAS6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005565 name: SASH1_human def: "SAM and SH3 domain-containing protein 1 gene" [UniProtKB:O94885] synonym: "KIAA0790" EXACT [UniProtKB:O94885] synonym: "PEPE1" EXACT [UniProtKB:O94885] xref: EMBL:AB018333 xref: EMBL:AJ507735 xref: EMBL:AK024403 xref: EMBL:AY351960 xref: EMBL:AY351961 xref: EMBL:AY351962 xref: EMBL:AY351963 xref: EMBL:AY351964 xref: EMBL:AY351965 xref: EMBL:AY351966 xref: EMBL:AY351967 xref: EMBL:AY351968 xref: EMBL:AY351969 xref: EMBL:AY351970 xref: EMBL:AY351971 xref: EMBL:AY351972 xref: EMBL:AY351973 xref: EMBL:AY351974 xref: EMBL:AY351975 xref: EMBL:AY351976 xref: EMBL:AY351977 xref: EMBL:AY351978 xref: EMBL:AY351979 xref: EMBL:BC028303 xref: EMBL:BN000088 xref: HGNC:HGNC:19182 xref: UniGene:Hs.193133 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001444 ! SASH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005566 name: SAT1_human def: "Diamine acetyltransferase 1 gene" [UniProtKB:P21673] synonym: "SAT" EXACT [UniProtKB:P21673] xref: EMBL:BC002503 xref: EMBL:BC008424 xref: EMBL:BT006825 xref: EMBL:M55580 xref: EMBL:M77693 xref: EMBL:U40369 xref: EMBL:Z14136 xref: HGNC:HGNC:10540 xref: UniGene:Hs.28491 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006107 ! SAT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005567 name: SATB1_human def: "DNA-binding protein SATB1 gene" [UniProtKB:Q01826] xref: EMBL:BC001744 xref: EMBL:M97287 xref: HGNC:HGNC:10541 xref: UniGene:Hs.517717 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005191 ! SATB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005568 name: SELENBP1_human def: "Selenium-binding protein 1 gene" [UniProtKB:Q13228] synonym: "SBP" EXACT [UniProtKB:Q13228] xref: EMBL:AL391069 xref: EMBL:BC009084 xref: EMBL:CH471121 xref: EMBL:CR456852 xref: EMBL:U29091 xref: HGNC:HGNC:10719 xref: UniGene:Hs.632460 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006083 ! SBP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005569 name: SEC23A_human def: "Protein transport protein Sec23A gene" [UniProtKB:Q15436] xref: EMBL:AL109628 xref: EMBL:BC036649 xref: EMBL:X97064 xref: HGNC:HGNC:10701 xref: UniGene:Hs.272927 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005583 ! SC23A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005570 name: SCAMP1_human def: "Secretory carrier-associated membrane protein 1 gene" [UniProtKB:O15126] synonym: "SCAMP" EXACT [UniProtKB:O15126] xref: EMBL:AF005037 xref: EMBL:AF038966 xref: EMBL:BC009787 xref: EMBL:BC015065 xref: EMBL:BC034048 xref: HGNC:HGNC:10563 xref: UniGene:Hs.482587 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005624 ! SCAM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005571 name: SCFD1_human def: "Sec1 family domain-containing protein 1 gene" [UniProtKB:Q8WVM8] synonym: "C14orf163" EXACT [UniProtKB:Q8WVM8] synonym: "FKSG23" EXACT [UniProtKB:Q8WVM8] synonym: "KIAA0917" EXACT [UniProtKB:Q8WVM8] synonym: "STXBP1L2" EXACT [UniProtKB:Q8WVM8] xref: EMBL:AB020724 xref: EMBL:AF067205 xref: EMBL:AF086916 xref: EMBL:AF092139 xref: EMBL:AF110646 xref: EMBL:AF319958 xref: EMBL:BC017734 xref: HGNC:HGNC:20726 xref: UniGene:Hs.369168 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006349 ! SCFD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005572 name: CHGB_human def: "Secretogranin-1 precursor gene" [UniProtKB:P05060] synonym: "SCG1" EXACT [UniProtKB:P05060] xref: EMBL:AL035461 xref: EMBL:BC000375 xref: EMBL:Y00064 xref: HGNC:HGNC:1930 xref: UniGene:Hs.516874 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006217 ! SCG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005573 name: SCN5A_human def: "Sodium channel protein type 5 subunit alpha gene" [UniProtKB:Q14524] xref: EMBL:M77235 xref: HGNC:HGNC:10593 xref: UniGene:Hs.517898 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006346 ! SCN5A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005574 name: SCNM1_human def: "Sodium channel modifier 1 gene" [UniProtKB:Q9BWG6] xref: EMBL:AK056322 xref: EMBL:AL592424 xref: EMBL:BC000264 xref: HGNC:HGNC:23136 xref: UniGene:Hs.432360 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005251 ! SCNM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005575 name: PPBP_human def: "Platelet basic protein precursor gene" [UniProtKB:P02775] synonym: "CTAP3" EXACT [UniProtKB:P02775] synonym: "CXCL7" EXACT [UniProtKB:P02775] synonym: "SCYB7" EXACT [UniProtKB:P02775] synonym: "TGB1" EXACT [UniProtKB:P02775] synonym: "THBGB1" EXACT [UniProtKB:P02775] xref: EMBL:AC097709 xref: EMBL:AF349466 xref: EMBL:BC028217 xref: EMBL:CR456805 xref: EMBL:M54995 xref: HGNC:HGNC:9240 xref: UniGene:Hs.2164 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0035955 ! CXCL7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005576 name: SDC2_human def: "Syndecan-2 precursor gene" [UniProtKB:P34741] synonym: "HSPG1" EXACT [UniProtKB:P34741] xref: EMBL:AK025488 xref: EMBL:BC049836 xref: EMBL:J04621 xref: HGNC:HGNC:10659 xref: UniGene:Hs.1501 xref: UniGene:Hs.598247 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005445 ! SDC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005577 name: SUDS3_human def: "Sin3 histone deacetylase corepressor complex component SDS3 gene" [UniProtKB:Q9H7L9] synonym: "SAP45" EXACT [UniProtKB:Q9H7L9] synonym: "SDS3" EXACT [UniProtKB:Q9H7L9] xref: EMBL:AK023801 xref: EMBL:AK024460 xref: EMBL:BC030252 xref: EMBL:BC098404 xref: HGNC:HGNC:29545 xref: UniGene:Hs.416630 xref: UniGene:Hs.602312 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005694 ! SDS3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005578 name: SEC13_human def: "Protein SEC13 homolog gene" [UniProtKB:P55735] synonym: "D3S1231E" EXACT [UniProtKB:P55735] synonym: "SEC13L1" EXACT [UniProtKB:P55735] synonym: "SEC13R" EXACT [UniProtKB:P55735] xref: EMBL:BC002634 xref: EMBL:BC006167 xref: EMBL:BC091506 xref: EMBL:L09260 xref: HGNC:HGNC:10697 xref: UniGene:Hs.166924 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005452 ! SEC13_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005579 name: SENP5_human def: "Sentrin-specific protease 5 gene" [UniProtKB:Q96HI0] synonym: "FKSG45" EXACT [UniProtKB:Q96HI0] xref: EMBL:AF335474 xref: EMBL:BC008589 xref: EMBL:BC030705 xref: HGNC:HGNC:28407 xref: UniGene:Hs.240770 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002041 ! SENP5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005580 name: SENP7_human def: "Sentrin-specific protease 7 gene" [UniProtKB:Q9BQF6] synonym: "KIAA1707" EXACT [UniProtKB:Q9BQF6] synonym: "SSP2" EXACT [UniProtKB:Q9BQF6] synonym: "SUSP2" EXACT [UniProtKB:Q9BQF6] xref: EMBL:AB051494 xref: EMBL:AF199458 xref: EMBL:AF217504 xref: EMBL:AL136599 xref: EMBL:BX537943 xref: HGNC:HGNC:30402 xref: UniGene:Hs.529551 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006018 ! SENP7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005581 name: SEPT10_human def: "Septin-10 gene" [UniProtKB:Q9P0V9] xref: EMBL:AC140485 xref: EMBL:AF146760 xref: EMBL:AK021681 xref: EMBL:BC020502 xref: EMBL:BC050345 xref: HGNC:HGNC:14349 xref: UniGene:Hs.469615 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002183 ! SEP10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005582 name: SEPT11_human def: "Septin-11 gene" [UniProtKB:Q9NVA2] xref: EMBL:AK001711 xref: EMBL:AK027633 xref: EMBL:BC008083 xref: EMBL:BC063615 xref: HGNC:HGNC:25589 xref: UniGene:Hs.128199 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002169 ! SEP11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005583 name: SEPT14_human def: "Septin-14 gene" [UniProtKB:Q6ZU15] xref: EMBL:AC092647 xref: EMBL:AK126048 xref: HGNC:HGNC:33280 xref: UniGene:Hs.453629 xref: UniGene:Hs.700061 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001925 ! SEP14_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005584 name: SEPT1_human def: "Septin-1 gene" [UniProtKB:Q8WYJ6] synonym: "DIFF6" EXACT [UniProtKB:Q8WYJ6] synonym: "PNUTL3" EXACT [UniProtKB:Q8WYJ6] xref: EMBL:AF085235 xref: EMBL:AF308288 xref: EMBL:AY034176 xref: EMBL:BC012161 xref: HGNC:HGNC:2879 xref: UniGene:Hs.632176 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002011 ! SEPT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005585 name: SEPT2_human def: "Septin-2 gene" [UniProtKB:Q15019] synonym: "DIFF6" EXACT [UniProtKB:Q15019] synonym: "KIAA0158" EXACT [UniProtKB:Q15019] synonym: "NEDD5" EXACT [UniProtKB:Q15019] xref: EMBL:AF038404 xref: EMBL:BC014455 xref: EMBL:BC033559 xref: EMBL:D28540 xref: EMBL:D63878 xref: HGNC:HGNC:7729 xref: UniGene:Hs.335057 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001800 ! SEPT2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005586 name: SEPT3_human def: "Neuronal-specific septin-3 gene" [UniProtKB:Q9UH03] synonym: "SEP3" EXACT [UniProtKB:Q9UH03] xref: EMBL:AB209152 xref: EMBL:AF285107 xref: EMBL:AF285108 xref: EMBL:AF285109 xref: EMBL:AL833942 xref: EMBL:BC111779 xref: EMBL:CR456572 xref: EMBL:Z99716 xref: HGNC:HGNC:10750 xref: UniGene:Hs.120483 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002198 ! SEPT3_HUMAN relationship: codes_for CCO:B0041227 ! B1AHR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005587 name: SEPT4_human def: "Septin-4 gene" [UniProtKB:O43236] synonym: "hucep-7" EXACT [UniProtKB:O43236] synonym: "PNUTL2" EXACT [UniProtKB:O43236] xref: EMBL:AB008753 xref: EMBL:AF035811 xref: EMBL:AF073312 xref: EMBL:BC018056 xref: EMBL:CH471109 xref: EMBL:CR457111 xref: EMBL:D89278 xref: EMBL:U88829 xref: EMBL:U88870 xref: HGNC:HGNC:9165 xref: UniGene:Hs.287518 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001382 ! SEPT4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005588 name: SEPT5_human def: "Septin-5 gene" [UniProtKB:Q99719] synonym: "PNUTL1" EXACT [UniProtKB:Q99719] xref: EMBL:AF006988 xref: EMBL:BC025261 xref: EMBL:CR456545 xref: EMBL:U74628 xref: EMBL:Y11593 xref: HGNC:HGNC:9164 xref: UniGene:Hs.283743 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002079 ! Q99648_HUMAN relationship: codes_for CCO:B0002085 ! SEPT5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005589 name: SEPT6_human def: "Septin-6 gene" [UniProtKB:Q14141] synonym: "KIAA0128" EXACT [UniProtKB:Q14141] synonym: "SEP2" EXACT [UniProtKB:Q14141] xref: EMBL:AC004913 xref: EMBL:AC005052 xref: EMBL:AF397023 xref: EMBL:AF403058 xref: EMBL:AF403059 xref: EMBL:AF403060 xref: EMBL:AF403061 xref: EMBL:AF403062 xref: EMBL:AK290977 xref: EMBL:AL355348 xref: EMBL:AY005981 xref: EMBL:AY034177 xref: EMBL:BC009291 xref: EMBL:BC011922 xref: EMBL:BC036240 xref: EMBL:CH471161 xref: EMBL:D50918 xref: HGNC:HGNC:15848 xref: UniGene:Hs.496666 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001775 ! SEPT6_HUMAN relationship: codes_for CCO:B0033797 ! Q548C9_HUMAN relationship: codes_for CCO:B0033798 ! Q541S4_HUMAN relationship: codes_for CCO:B0041234 ! B1AMS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005590 name: SEPT7_human def: "Septin-7 gene" [UniProtKB:Q16181] synonym: "CDC10" EXACT [UniProtKB:Q16181] xref: EMBL:BC067264 xref: EMBL:BC093640 xref: EMBL:BC093642 xref: EMBL:S72008 xref: HGNC:HGNC:1717 xref: UniGene:Hs.191346 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001816 ! SEPT7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005591 name: SEPT8_human def: "Septin-8 gene" [UniProtKB:Q92599] synonym: "KIAA0202" EXACT [UniProtKB:Q92599] xref: EMBL:AC004775 xref: EMBL:AF179995 xref: EMBL:AF440761 xref: EMBL:AF440762 xref: EMBL:AF440763 xref: EMBL:BC001329 xref: EMBL:D86957 xref: HGNC:HGNC:16511 xref: UniGene:Hs.533017 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001319 ! A6NC65_HUMAN relationship: codes_for CCO:B0001324 ! A6NFQ9_HUMAN relationship: codes_for CCO:B0001335 ! A6NKP6_HUMAN relationship: codes_for CCO:B0001339 ! A6NMH6_HUMAN relationship: codes_for CCO:B0002015 ! SEPT8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005592 name: SEPT9_human def: "Septin-9 gene" [UniProtKB:Q9UHD8] synonym: "KIAA0991" EXACT [UniProtKB:Q9UHD8] synonym: "MSF" EXACT [UniProtKB:Q9UHD8] xref: EMBL:AB023208 xref: EMBL:AF123052 xref: EMBL:AF142408 xref: EMBL:AF189712 xref: EMBL:AF189713 xref: EMBL:AJ312319 xref: EMBL:AJ312320 xref: EMBL:AJ312321 xref: EMBL:AJ312322 xref: EMBL:AK022493 xref: EMBL:AL080131 xref: EMBL:BC021192 xref: EMBL:BC054004 xref: EMBL:BC114550 xref: EMBL:BT007215 xref: HGNC:HGNC:7323 xref: UniGene:Hs.440932 xref: UniGene:Hs.672188 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001827 ! Q1WWK5_HUMAN relationship: codes_for CCO:B0002201 ! SEPT9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005593 name: SESN1_human def: "Sestrin-1 gene" [UniProtKB:Q9Y6P5] synonym: "PA26" EXACT [UniProtKB:Q9Y6P5] synonym: "SEST1" EXACT [UniProtKB:Q9Y6P5] xref: EMBL:AF033120 xref: EMBL:AF033121 xref: EMBL:AF033122 xref: EMBL:AK001886 xref: HGNC:HGNC:21595 xref: UniGene:Hs.591336 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002266 ! SESN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005594 name: SESN2_human def: "Sestrin-2 gene" [UniProtKB:P58004] synonym: "SEST2" EXACT [UniProtKB:P58004] xref: EMBL:AK025640 xref: EMBL:AK027896 xref: EMBL:AL136551 xref: EMBL:AY123223 xref: EMBL:BC013304 xref: EMBL:BC033719 xref: HGNC:HGNC:20746 xref: UniGene:Hs.469543 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001681 ! SESN2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005595 name: SESN3_human def: "Sestrin-3 gene" [UniProtKB:P58005] synonym: "SEST3" EXACT [UniProtKB:P58005] xref: EMBL:AC016896 xref: EMBL:AC021174 xref: EMBL:AF086251 xref: EMBL:AK096300 xref: EMBL:BC017296 xref: EMBL:BF328700 xref: EMBL:BG291497 xref: HGNC:HGNC:23060 xref: UniGene:Hs.659934 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001682 ! SESN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005596 name: SETD1A_human def: "Histone-lysine N-methyltransferase SETD1A gene" [UniProtKB:O15047] synonym: "KIAA0339" EXACT [UniProtKB:O15047] synonym: "KMT2F" EXACT [UniProtKB:O15047] synonym: "SET1" EXACT [UniProtKB:O15047] synonym: "SET1A" EXACT [UniProtKB:O15047] xref: EMBL:AB002337 xref: EMBL:AC135048 xref: EMBL:BC027450 xref: EMBL:BC035795 xref: HGNC:HGNC:29010 xref: UniGene:Hs.297483 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005613 ! SET1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005597 name: SETDB1_human def: "Histone-lysine N-methyltransferase SETDB1 gene" [UniProtKB:Q15047] synonym: "KIAA0067" EXACT [UniProtKB:Q15047] synonym: "KMT1E" EXACT [UniProtKB:Q15047] xref: EMBL:AL590133 xref: EMBL:BC009362 xref: EMBL:BC028671 xref: EMBL:D31891 xref: HGNC:HGNC:10761 xref: UniGene:Hs.643565 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005404 ! SETB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005598 name: SET_human def: "Protein SET gene" [UniProtKB:Q01105] xref: EMBL:AK223556 xref: EMBL:AL356481 xref: EMBL:AY349172 xref: EMBL:BC032749 xref: EMBL:CR536543 xref: EMBL:CR542050 xref: EMBL:D45198 xref: EMBL:EF534308 xref: EMBL:M93651 xref: EMBL:U51924 xref: EMBL:X75091 xref: HGNC:HGNC:10760 xref: UniGene:Hs.436687 xref: UniGene:Hs.596814 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005519 ! SET_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005601 name: SGOL1_human def: "Shugoshin-like 1 gene" [UniProtKB:Q5FBB7] synonym: "SGO1" EXACT [UniProtKB:Q5FBB7] xref: EMBL:AB187577 xref: EMBL:AB187578 xref: EMBL:AB187579 xref: EMBL:AB187580 xref: EMBL:AB187581 xref: EMBL:AB187582 xref: EMBL:AB190994 xref: EMBL:AB193056 xref: EMBL:AB193057 xref: EMBL:AB193058 xref: EMBL:AB193059 xref: EMBL:AB193060 xref: EMBL:AB193061 xref: EMBL:AB193062 xref: EMBL:AB193063 xref: EMBL:AB193064 xref: EMBL:AB193065 xref: EMBL:AB193066 xref: EMBL:AF308299 xref: EMBL:BC001339 xref: EMBL:BC017867 xref: EMBL:BC032696 xref: HGNC:HGNC:25088 xref: UniGene:Hs.105153 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001847 ! SGOL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005602 name: SGOL2_human def: "Shugoshin-like 2 gene" [UniProtKB:Q562F6] xref: EMBL:AC012459 xref: EMBL:AC080164 xref: EMBL:AK057940 xref: EMBL:AK095291 xref: EMBL:AY094614 xref: EMBL:BC035764 xref: EMBL:BC048349 xref: EMBL:BC092412 xref: HGNC:HGNC:30812 xref: UniGene:Hs.655182 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001840 ! SGOL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005603 name: SGSM3_human def: "Small G protein signaling modulator 3 gene" [UniProtKB:Q96HU1] synonym: "MAP" EXACT [UniProtKB:Q96HU1] synonym: "RABGAPLP" EXACT [UniProtKB:Q96HU1] synonym: "RUTBC3" EXACT [UniProtKB:Q96HU1] xref: EMBL:AB196956 xref: EMBL:AB275763 xref: EMBL:AL022238 xref: EMBL:AL137499 xref: EMBL:AY308849 xref: EMBL:BC008078 xref: EMBL:CH471095 xref: EMBL:CR456441 xref: HGNC:HGNC:25228 xref: UniGene:Hs.474914 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002042 ! SGSM3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005606 name: SH3BP4_human def: "SH3 domain-binding protein 4 gene" [UniProtKB:Q9P0V3] synonym: "BOG25" EXACT [UniProtKB:Q9P0V3] synonym: "EHB10" EXACT [UniProtKB:Q9P0V3] synonym: "TTP" EXACT [UniProtKB:Q9P0V3] xref: EMBL:AC010148 xref: EMBL:AC114814 xref: EMBL:AF015043 xref: EMBL:AF147747 xref: EMBL:BC057396 xref: EMBL:DQ232895 xref: HGNC:HGNC:10826 xref: UniGene:Hs.516777 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002182 ! SH3B4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005607 name: SH3GL1_human def: "Endophilin-A2 gene" [UniProtKB:Q99961] synonym: "CNSA1" EXACT [UniProtKB:Q99961] synonym: "SH3D2B" EXACT [UniProtKB:Q99961] xref: EMBL:AF190465 xref: EMBL:BC001270 xref: EMBL:U65999 xref: EMBL:X99656 xref: HGNC:HGNC:10830 xref: UniGene:Hs.97616 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006310 ! SH3G1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005608 name: SH3GL2_human def: "Endophilin-A1 gene" [UniProtKB:Q99962] synonym: "CNSA2" EXACT [UniProtKB:Q99962] synonym: "SH3D2A" EXACT [UniProtKB:Q99962] xref: EMBL:AF036268 xref: EMBL:AL133214 xref: EMBL:AL139115 xref: EMBL:BT019682 xref: EMBL:CR542086 xref: EMBL:CR542102 xref: EMBL:X99657 xref: HGNC:HGNC:10831 xref: UniGene:Hs.75149 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006188 ! SH3G2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005609 name: SH3GL3_human def: "Endophilin-A3 gene" [UniProtKB:Q99963] synonym: "CNSA3" EXACT [UniProtKB:Q99963] synonym: "SH3D2C" EXACT [UniProtKB:Q99963] xref: EMBL:AF036269 xref: EMBL:AF036270 xref: EMBL:AF036271 xref: EMBL:AF036272 xref: EMBL:X99664 xref: HGNC:HGNC:10832 xref: UniGene:Hs.270055 xref: UniGene:Hs.666365 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006187 ! SH3G3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005610 name: SHC1_human def: "SHC-transforming protein 1 gene" [UniProtKB:P29353] synonym: "SHC" EXACT [UniProtKB:P29353] synonym: "SHCA" EXACT [UniProtKB:P29353] xref: EMBL:AK292143 xref: EMBL:AK315842 xref: EMBL:AL451085 xref: EMBL:BC014158 xref: EMBL:BC033925 xref: EMBL:CH471121 xref: EMBL:U73377 xref: EMBL:X68148 xref: EMBL:Y09847 xref: HGNC:HGNC:10840 xref: UniGene:Hs.433795 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001569 ! SHC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005611 name: SHOC2_human def: "Leucine-rich repeat protein SHOC-2 gene" [UniProtKB:Q9UQ13] synonym: "KIAA0862" EXACT [UniProtKB:Q9UQ13] xref: EMBL:AB020669 xref: EMBL:AF054828 xref: EMBL:AF068920 xref: EMBL:BC050445 xref: HGNC:HGNC:15454 xref: UniGene:Hs.104315 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005650 ! SHOC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005612 name: SIAH1_human def: "E3 ubiquitin-protein ligase SIAH1 gene" [UniProtKB:Q8IUQ4] synonym: "HUMSIAH" EXACT [UniProtKB:Q8IUQ4] xref: EMBL:AJ400626 xref: EMBL:BC035562 xref: EMBL:BC042550 xref: EMBL:BC044920 xref: EMBL:BX647064 xref: EMBL:EF026094 xref: EMBL:U63295 xref: EMBL:U76247 xref: HGNC:HGNC:10857 xref: UniGene:Hs.295923 xref: UniGene:Hs.700697 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001946 ! SIAH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005613 name: SIAH2_human def: "E3 ubiquitin-protein ligase SIAH2 gene" [UniProtKB:O43255] xref: EMBL:BC013082 xref: EMBL:U76248 xref: EMBL:Y15268 xref: HGNC:HGNC:10858 xref: UniGene:Hs.477959 xref: UniGene:Hs.692394 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001384 ! SIAH2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005614 name: SIN3A_human def: "Paired amphipathic helix protein Sin3a gene" [UniProtKB:Q96ST3] xref: EMBL:AF418569 xref: EMBL:AK027559 xref: EMBL:AK074903 xref: EMBL:AK096477 xref: EMBL:AL117513 xref: EMBL:AY044430 xref: EMBL:BC018973 xref: HGNC:HGNC:19353 xref: UniGene:Hs.513039 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005357 ! SIN3A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005615 name: SIN3B_human def: "Paired amphipathic helix protein Sin3b gene" [UniProtKB:O75182] synonym: "KIAA0700" EXACT [UniProtKB:O75182] xref: EMBL:AB014600 xref: EMBL:AY706204 xref: EMBL:BC005113 xref: EMBL:BC025026 xref: EMBL:BC063531 xref: HGNC:HGNC:19354 xref: UniGene:Hs.13999 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005807 ! SIN3B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005616 name: SIPA1_human def: "Signal-induced proliferation-associated protein 1 gene" [UniProtKB:Q96FS4] synonym: "SPA1" EXACT [UniProtKB:Q96FS4] xref: EMBL:AB005666 xref: EMBL:AF029789 xref: EMBL:AF052233 xref: EMBL:AF052234 xref: EMBL:AF052235 xref: EMBL:AF052236 xref: EMBL:AF052237 xref: EMBL:AF052238 xref: EMBL:BC010492 xref: EMBL:BC110353 xref: HGNC:HGNC:10885 xref: UniGene:Hs.530477 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002039 ! SIPA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005617 name: SIRT2_human def: "NAD-dependent deacetylase sirtuin-2 gene" [UniProtKB:Q8IXJ6] synonym: "SIR2L" EXACT [UniProtKB:Q8IXJ6] synonym: "SIR2L2" EXACT [UniProtKB:Q8IXJ6] xref: EMBL:AF083107 xref: EMBL:AF095714 xref: EMBL:AF131800 xref: EMBL:AF160214 xref: EMBL:AJ505014 xref: EMBL:AY030277 xref: EMBL:BC003012 xref: EMBL:BC003547 xref: HGNC:HGNC:10886 xref: UniGene:Hs.466693 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001951 ! SIRT2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005618 name: SKIV2L2_human def: "Superkiller viralicidic activity 2-like 2 gene" [UniProtKB:P42285] synonym: "KIAA0052" EXACT [UniProtKB:P42285] xref: EMBL:BC014669 xref: EMBL:BC028604 xref: EMBL:BC031779 xref: EMBL:BC065258 xref: EMBL:BC104996 xref: EMBL:BC113509 xref: EMBL:BX640789 xref: EMBL:D29641 xref: HGNC:HGNC:18734 xref: UniGene:Hs.274531 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005346 ! SK2L2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005619 name: SKA1_human def: "Spindle and kinetochore-associated protein 1 gene" [UniProtKB:Q96BD8] synonym: "C18orf24" EXACT [UniProtKB:Q96BD8] xref: EMBL:BC015706 xref: HGNC:HGNC:28109 xref: UniGene:Hs.134726 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002032 ! SKA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005620 name: FAM33A_human def: "Spindle and kinetochore-associated protein 2 gene" [UniProtKB:Q8WVK7] synonym: "SKA2" EXACT [UniProtKB:Q8WVK7] xref: EMBL:BC017873 xref: EMBL:BC106003 xref: HGNC:HGNC:28006 xref: UniGene:Hs.463607 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002003 ! SKA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005621 name: SKIV2L_human def: "Helicase SKI2W gene" [UniProtKB:Q15477] synonym: "DDX13" EXACT [UniProtKB:Q15477] synonym: "SKI2W" EXACT [UniProtKB:Q15477] synonym: "SKIV2" EXACT [UniProtKB:Q15477] synonym: "W" EXACT [UniProtKB:Q15477] xref: EMBL:AF019413 xref: EMBL:U09877 xref: EMBL:X98378 xref: EMBL:Z48796 xref: HGNC:HGNC:10898 xref: UniGene:Hs.89864 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005565 ! SKIV2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005623 name: SKP2_human def: "S-phase kinase-associated protein 2 gene" [UniProtKB:Q13309] synonym: "FBXL1" EXACT [UniProtKB:Q13309] xref: EMBL:AB050979 xref: EMBL:AB050980 xref: EMBL:AB050981 xref: EMBL:AY029177 xref: EMBL:BC001441 xref: EMBL:BC007441 xref: EMBL:U33761 xref: HGNC:HGNC:10901 xref: UniGene:Hs.23348 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001749 ! SKP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005624 name: SMAD4_human def: "Mothers against decapentaplegic homolog 4 gene" [UniProtKB:Q13485] synonym: "DPC4" EXACT [UniProtKB:Q13485] synonym: "MADH4" EXACT [UniProtKB:Q13485] xref: EMBL:AF045438 xref: EMBL:AF045439 xref: EMBL:AF045440 xref: EMBL:AF045441 xref: EMBL:AF045442 xref: EMBL:AF045443 xref: EMBL:AF045444 xref: EMBL:AF045445 xref: EMBL:AF045446 xref: EMBL:AF045447 xref: EMBL:BC002379 xref: EMBL:U44378 xref: HGNC:HGNC:6770 xref: UniGene:Hs.592888 xref: UniGene:Hs.75862 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005322 ! SMAD4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005625 name: SMC1A_human def: "Structural maintenance of chromosomes protein 1A gene" [UniProtKB:Q14683] synonym: "DXS423E" EXACT [UniProtKB:Q14683] synonym: "KIAA0178" EXACT [UniProtKB:Q14683] synonym: "SB1.8" EXACT [UniProtKB:Q14683] synonym: "SMC1" EXACT [UniProtKB:Q14683] synonym: "SMC1L1" EXACT [UniProtKB:Q14683] xref: EMBL:AL161779 xref: EMBL:BC112127 xref: EMBL:D80000 xref: EMBL:S78271 xref: EMBL:Z97054 xref: HGNC:HGNC:11111 xref: UniGene:Hs.211602 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001790 ! SMC1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005626 name: SMC1B_human def: "Structural maintenance of chromosomes protein 1B gene" [UniProtKB:Q8NDV3] synonym: "SMC1L2" EXACT [UniProtKB:Q8NDV3] xref: EMBL:AJ504806 xref: EMBL:AL008718 xref: EMBL:AL021391 xref: HGNC:HGNC:11112 xref: UniGene:Hs.334176 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001977 ! SMC1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005627 name: SMC2_human def: "Structural maintenance of chromosomes protein 2 gene" [UniProtKB:O95347] synonym: "CAPE" EXACT [UniProtKB:O95347] synonym: "PRO0324" EXACT [UniProtKB:O95347] synonym: "SMC2L1" EXACT [UniProtKB:O95347] xref: EMBL:AF092563 xref: EMBL:AF113673 xref: HGNC:HGNC:14011 xref: UniGene:Hs.119023 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001450 ! SMC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005628 name: SMC3_human def: "Structural maintenance of chromosomes protein 3 gene" [UniProtKB:Q9UQE7] synonym: "BAM" EXACT [UniProtKB:Q9UQE7] synonym: "BMH" EXACT [UniProtKB:Q9UQE7] synonym: "CSPG6" EXACT [UniProtKB:Q9UQE7] synonym: "SMC3L1" EXACT [UniProtKB:Q9UQE7] xref: EMBL:AF020043 xref: EMBL:AF067163 xref: EMBL:AJ005015 xref: EMBL:AL359260 xref: HGNC:HGNC:2468 xref: UniGene:Hs.24485 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002243 ! SMC3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005629 name: SMC4_human def: "Structural maintenance of chromosomes protein 4 gene" [UniProtKB:Q9NTJ3] synonym: "CAPC" EXACT [UniProtKB:Q9NTJ3] synonym: "SMC4L1" EXACT [UniProtKB:Q9NTJ3] xref: EMBL:AB019987 xref: EMBL:AC024221 xref: EMBL:AF092564 xref: EMBL:AL136877 xref: EMBL:AL833949 xref: EMBL:CH471052 xref: HGNC:HGNC:14013 xref: UniGene:Hs.58992 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002168 ! SMC4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005630 name: SMARCA2_human def: "Probable global transcription activator SNF2L2 gene" [UniProtKB:P51531] synonym: "BRM" EXACT [UniProtKB:P51531] synonym: "SNF2A" EXACT [UniProtKB:P51531] synonym: "SNF2L2" EXACT [UniProtKB:P51531] xref: EMBL:D26155 xref: EMBL:X72889 xref: HGNC:HGNC:11098 xref: UniGene:Hs.298990 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005925 ! SMCA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005631 name: SMARCA4_human def: "Probable global transcription activator SNF2L4 gene" [UniProtKB:P51532] synonym: "BRG1" EXACT [UniProtKB:P51532] synonym: "SNF2B" EXACT [UniProtKB:P51532] synonym: "SNF2L4" EXACT [UniProtKB:P51532] xref: EMBL:AC006127 xref: EMBL:AC011442 xref: EMBL:AC011485 xref: EMBL:AF254822 xref: EMBL:D26156 xref: EMBL:U29175 xref: HGNC:HGNC:11100 xref: UniGene:Hs.327527 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005414 ! SMCA4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005632 name: SMARCE1_human def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 gene" [UniProtKB:Q969G3] synonym: "BAF57" EXACT [UniProtKB:Q969G3] xref: EMBL:AF035262 xref: EMBL:BC007082 xref: EMBL:BC011017 xref: EMBL:BC063700 xref: EMBL:BT007176 xref: HGNC:HGNC:11109 xref: UniGene:Hs.696086 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005416 ! SMCE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005633 name: SMN1_human def: "Survival motor neuron protein gene" [UniProtKB:Q16637] synonym: "SMN" EXACT [UniProtKB:Q16637] synonym: "SMNT" EXACT [UniProtKB:Q16637] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006110 ! SMN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005634 name: SMN2_human def: "Survival motor neuron protein gene" [UniProtKB:Q16637] synonym: "SMNC" EXACT [UniProtKB:Q16637] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006110 ! SMN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005635 name: SMO_human def: "Smoothened homolog precursor gene" [UniProtKB:Q99835] synonym: "SMOH" EXACT [UniProtKB:Q99835] xref: EMBL:AF071494 xref: EMBL:AF114819 xref: EMBL:AF114820 xref: EMBL:AF114821 xref: EMBL:AF120103 xref: EMBL:BC009989 xref: EMBL:U84401 xref: HGNC:HGNC:11119 xref: UniGene:Hs.437846 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006039 ! SMO_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005636 name: SMARCC1_human def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 gene" [UniProtKB:Q92922] synonym: "BAF155" EXACT [UniProtKB:Q92922] xref: EMBL:BC039843 xref: EMBL:BC065253 xref: EMBL:U66615 xref: HGNC:HGNC:11104 xref: UniGene:Hs.476179 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005418 ! SMRC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005637 name: SMARCC2_human def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 gene" [UniProtKB:Q8TAQ2] synonym: "BAF170" EXACT [UniProtKB:Q8TAQ2] xref: EMBL:BC009067 xref: EMBL:BC013045 xref: EMBL:BC026222 xref: EMBL:BT009924 xref: EMBL:U66616 xref: HGNC:HGNC:11105 xref: UniGene:Hs.236030 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005417 ! SMRC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005638 name: SMARCD1_human def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 gene" [UniProtKB:Q96GM5] synonym: "BAF60A" EXACT [UniProtKB:Q96GM5] xref: EMBL:AF109733 xref: EMBL:BC009368 xref: EMBL:U66617 xref: HGNC:HGNC:11106 xref: UniGene:Hs.79335 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005415 ! SMRD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005639 name: SMARCD2_human def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 gene" [UniProtKB:Q92925] synonym: "BAF60B" EXACT [UniProtKB:Q92925] synonym: "PRO2451" EXACT [UniProtKB:Q92925] xref: EMBL:AF113019 xref: EMBL:BC018953 xref: EMBL:U66618 xref: HGNC:HGNC:11107 xref: UniGene:Hs.250581 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005419 ! SMRD2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005640 name: SMU1_human def: "WD40 repeat-containing protein SMU1 gene" [UniProtKB:Q2TAY7] xref: EMBL:AK001667 xref: EMBL:AK022032 xref: EMBL:AL162590 xref: EMBL:BC002876 xref: EMBL:BC110654 xref: HGNC:HGNC:18247 xref: UniGene:Hs.655351 xref: UniGene:Hs.679417 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005691 ! SMU1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005641 name: SNF1LK_human def: "Serine/threonine-protein kinase SNF1-like kinase 1 gene" [UniProtKB:P57059] synonym: "SIK" EXACT [UniProtKB:P57059] xref: EMBL:AB047786 xref: EMBL:AK131076 xref: EMBL:AP001751 xref: EMBL:BC038504 xref: HGNC:HGNC:11142 xref: UniGene:Hs.282113 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001680 ! SN1L1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005644 name: SMARCB1_human def: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 gene" [UniProtKB:Q12824] synonym: "INI1" EXACT [UniProtKB:Q12824] synonym: "SNF5L1" EXACT [UniProtKB:Q12824] xref: EMBL:AB017523 xref: EMBL:AJ011737 xref: EMBL:AJ011738 xref: EMBL:CR456581 xref: EMBL:DQ230988 xref: EMBL:U04847 xref: EMBL:Y17118 xref: EMBL:Y17119 xref: EMBL:Y17120 xref: EMBL:Y17121 xref: EMBL:Y17122 xref: EMBL:Y17123 xref: EMBL:Y17124 xref: EMBL:Y17125 xref: EMBL:Y17126 xref: HGNC:HGNC:11103 xref: UniGene:Hs.534350 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001732 ! SNF5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005645 name: SNIP1_human def: "Smad nuclear-interacting protein 1 gene" [UniProtKB:Q8TAD8] xref: EMBL:AK022615 xref: EMBL:AK027622 xref: EMBL:AY081909 xref: EMBL:BC027040 xref: HGNC:HGNC:30587 xref: UniGene:Hs.471951 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005335 ! SNIP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005646 name: SART1_human def: "U4/U6.U5 tri-snRNP-associated protein 1 gene" [UniProtKB:O43290] xref: EMBL:AB006198 xref: EMBL:AF109680 xref: EMBL:AF353625 xref: EMBL:AK223016 xref: EMBL:AP006287 xref: EMBL:BC001058 xref: EMBL:BT006637 xref: HGNC:HGNC:10538 xref: UniGene:Hs.502883 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001388 ! SNUT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005647 name: SNX9_human def: "Sorting nexin-9 gene" [UniProtKB:Q9Y5X1] synonym: "SH3PX1" EXACT [UniProtKB:Q9Y5X1] synonym: "SH3PXD3A" EXACT [UniProtKB:Q9Y5X1] xref: EMBL:AF076957 xref: EMBL:AF121859 xref: EMBL:AF131214 xref: EMBL:AF172847 xref: EMBL:AL035634 xref: EMBL:AL139330 xref: EMBL:AL391863 xref: EMBL:BC001084 xref: EMBL:BC005022 xref: HGNC:HGNC:14973 xref: UniGene:Hs.191213 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005559 ! SNX9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005648 name: SOCS3_human def: "Suppressor of cytokine signaling 3 gene" [UniProtKB:O14543] synonym: "CIS3" EXACT [UniProtKB:O14543] synonym: "SSI3" EXACT [UniProtKB:O14543] xref: EMBL:AB004904 xref: EMBL:AB006967 xref: EMBL:AF159854 xref: EMBL:BC060858 xref: HGNC:HGNC:19391 xref: UniGene:Hs.527973 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006162 ! SOCS3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005649 name: SOS1_human def: "Son of sevenless homolog 1 gene" [UniProtKB:Q07889] xref: EMBL:L13857 xref: HGNC:HGNC:11187 xref: UniGene:Hs.654397 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005383 ! SOS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005650 name: SOS2_human def: "Son of sevenless homolog 2 gene" [UniProtKB:Q07890] xref: EMBL:L13858 xref: EMBL:L20686 xref: HGNC:HGNC:11188 xref: UniGene:Hs.291533 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005666 ! SOS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005651 name: SP1_human def: "Transcription factor Sp1 gene" [UniProtKB:P08047] synonym: "TSFP1" EXACT [UniProtKB:P08047] xref: EMBL:AB039286 xref: EMBL:AF252284 xref: EMBL:AF255682 xref: EMBL:AJ272134 xref: EMBL:BC043224 xref: EMBL:BC062539 xref: EMBL:J03133 xref: HGNC:HGNC:11205 xref: UniGene:Hs.620754 xref: UniGene:Hs.649191 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005485 ! SP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005652 name: SPAG5_human def: "Sperm-associated antigen 5 gene" [UniProtKB:Q96R06] xref: EMBL:AF063308 xref: EMBL:AF345347 xref: EMBL:AF399910 xref: EMBL:AL122116 xref: EMBL:AL137585 xref: EMBL:BC000322 xref: HGNC:HGNC:13452 xref: UniGene:Hs.514033 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002058 ! SPAG5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005653 name: SERPINB9_human def: "Serpin B9 gene" [UniProtKB:P50453] synonym: "PI9" EXACT [UniProtKB:P50453] xref: EMBL:AB060690 xref: EMBL:AL133351 xref: EMBL:BC002538 xref: EMBL:BT006673 xref: EMBL:CH471087 xref: EMBL:CR407627 xref: EMBL:L40378 xref: EMBL:U71364 xref: HGNC:HGNC:8955 xref: UniGene:Hs.104879 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006108 ! SPB9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005655 name: SPC25_human def: "Kinetochore protein Spc25 gene" [UniProtKB:Q9HBM1] synonym: "AD024" EXACT [UniProtKB:Q9HBM1] synonym: "SPBC25" EXACT [UniProtKB:Q9HBM1] xref: EMBL:AC069137 xref: EMBL:AF225416 xref: EMBL:AY456388 xref: EMBL:BC022255 xref: EMBL:CR457197 xref: HGNC:HGNC:24031 xref: UniGene:Hs.421956 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002143 ! SPC25_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005656 name: SPDYA_human def: "Speedy protein A gene" [UniProtKB:Q5MJ70] synonym: "SPDY1" EXACT [UniProtKB:Q5MJ70] synonym: "SPY1" EXACT [UniProtKB:Q5MJ70] xref: EMBL:AC097720 xref: EMBL:AY820303 xref: EMBL:AY820304 xref: EMBL:BC093005 xref: HGNC:HGNC:30613 xref: UniGene:Hs.511956 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001862 ! SPDYA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005657 name: SPDYC_human def: "Speedy protein C gene" [UniProtKB:Q5MJ68] xref: EMBL:AY820305 xref: HGNC:HGNC:32681 xref: UniGene:Hs.450642 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001861 ! SPDYC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005658 name: SPG7_human def: "Paraplegin gene" [UniProtKB:Q9UQ90] synonym: "CAR" EXACT [UniProtKB:Q9UQ90] synonym: "CMAR" EXACT [UniProtKB:Q9UQ90] synonym: "PGN" EXACT [UniProtKB:Q9UQ90] xref: EMBL:AF080511 xref: EMBL:AF080512 xref: EMBL:AF080513 xref: EMBL:AF080514 xref: EMBL:AF080515 xref: EMBL:AF080516 xref: EMBL:AF080517 xref: EMBL:AF080518 xref: EMBL:AF080519 xref: EMBL:AF080520 xref: EMBL:AF080521 xref: EMBL:AF080522 xref: EMBL:AF080523 xref: EMBL:AF080524 xref: EMBL:AF080525 xref: EMBL:BC007692 xref: EMBL:BC035929 xref: EMBL:BC036104 xref: EMBL:BC110530 xref: EMBL:BC110531 xref: EMBL:Y16610 xref: HGNC:HGNC:11237 xref: UniGene:Hs.185597 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006236 ! SPG7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005660 name: SPHK1_human def: "Sphingosine kinase 1 gene" [UniProtKB:Q9NYA1] synonym: "SPHK" EXACT [UniProtKB:Q9NYA1] synonym: "SPK" EXACT [UniProtKB:Q9NYA1] xref: EMBL:AF200328 xref: EMBL:AF238083 xref: EMBL:AF266756 xref: EMBL:AJ245504 xref: EMBL:AK022402 xref: EMBL:AK023393 xref: HGNC:HGNC:11240 xref: UniGene:Hs.68061 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002176 ! SPHK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005661 name: SPIN2A_human def: "Spindlin-2A gene" [UniProtKB:Q99865] synonym: "DXF34" EXACT [UniProtKB:Q99865] synonym: "SPIN2" EXACT [UniProtKB:Q99865] xref: EMBL:AL022157 xref: EMBL:BC071694 xref: EMBL:Y09858 xref: HGNC:HGNC:20694 xref: UniGene:Hs.460725 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002090 ! SPI2A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005662 name: SPIN2B_human def: "Spindlin-2B gene" [UniProtKB:Q9BPZ2] synonym: "SPIN2" EXACT [UniProtKB:Q9BPZ2] xref: EMBL:AF356353 xref: EMBL:AL022157 xref: EMBL:BC000044 xref: EMBL:BC071974 xref: HGNC:HGNC:33147 xref: UniGene:Hs.659479 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002093 ! SPI2B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005663 name: SPIN1_human def: "Spindlin-1 gene" [UniProtKB:Q9Y657] synonym: "OCR" EXACT [UniProtKB:Q9Y657] synonym: "SPIN" EXACT [UniProtKB:Q9Y657] xref: EMBL:AF087864 xref: EMBL:AF106682 xref: EMBL:AF317228 xref: EMBL:AL136719 xref: EMBL:AL353748 xref: EMBL:BC114515 xref: EMBL:BC114565 xref: EMBL:BT007314 xref: EMBL:CR533484 xref: HGNC:HGNC:11243 xref: UniGene:Hs.146804 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002262 ! SPIN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005664 name: SPO11_human def: "Meiotic recombination protein SPO11 gene" [UniProtKB:Q9Y5K1] xref: EMBL:AF149310 xref: EMBL:AF169385 xref: EMBL:AL135939 xref: EMBL:AY957583 xref: EMBL:BC033591 xref: HGNC:HGNC:11250 xref: UniGene:Hs.159737 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001337 ! A6NLT8_HUMAN relationship: codes_for CCO:B0001886 ! Q5TCH6_HUMAN relationship: codes_for CCO:B0001887 ! Q5TCH7_HUMAN relationship: codes_for CCO:B0002256 ! SPO11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005665 name: SPOP_human def: "Speckle-type POZ protein gene" [UniProtKB:O43791] xref: EMBL:AJ000644 xref: EMBL:AK222589 xref: EMBL:BC001269 xref: EMBL:BC003385 xref: HGNC:HGNC:11254 xref: UniGene:Hs.463382 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005292 ! SPOP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005666 name: SUPT5H_human def: "Transcription elongation factor SPT5 gene" [UniProtKB:O00267] synonym: "SPT5" EXACT [UniProtKB:O00267] synonym: "SPT5H" EXACT [UniProtKB:O00267] xref: EMBL:AB000516 xref: EMBL:AB209257 xref: EMBL:AF040253 xref: EMBL:BC024203 xref: EMBL:U56402 xref: EMBL:Y12790 xref: HGNC:HGNC:11469 xref: UniGene:Hs.631604 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001345 ! SPT5H_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005667 name: SPTBN1_human def: "Spectrin beta chain, brain 1 gene" [UniProtKB:Q01082] synonym: "SPTB2" EXACT [UniProtKB:Q01082] xref: EMBL:AB209748 xref: EMBL:AC092839 xref: EMBL:AC093110 xref: EMBL:AF327441 xref: EMBL:AJ005694 xref: EMBL:AJ238723 xref: EMBL:M96803 xref: EMBL:S65762 xref: HGNC:HGNC:11275 xref: UniGene:Hs.503178 xref: UniGene:Hs.705692 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005604 ! SPTB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005668 name: SPTLC2_human def: "Serine palmitoyltransferase 2 gene" [UniProtKB:O15270] synonym: "KIAA0526" EXACT [UniProtKB:O15270] synonym: "LCB2" EXACT [UniProtKB:O15270] xref: EMBL:AB011098 xref: EMBL:AF111168 xref: EMBL:BC005123 xref: EMBL:U15555 xref: EMBL:Y08686 xref: HGNC:HGNC:11278 xref: UniGene:Hs.435661 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006017 ! SPTC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005669 name: SORBS1_human def: "Sorbin and SH3 domain-containing protein 1 gene" [UniProtKB:Q9BX66] synonym: "KIAA1296" EXACT [UniProtKB:Q9BX66] synonym: "SH3D5" EXACT [UniProtKB:Q9BX66] xref: EMBL:AB037717 xref: EMBL:AF136380 xref: EMBL:AF136381 xref: EMBL:AF330623 xref: EMBL:AF330624 xref: EMBL:AF356525 xref: EMBL:AF356526 xref: EMBL:AF356527 xref: EMBL:AJ489942 xref: EMBL:AL117472 xref: EMBL:BC042612 xref: EMBL:U70668 xref: HGNC:HGNC:14565 xref: UniGene:Hs.696027 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005641 ! SRBS1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005670 name: SRC_human def: "Proto-oncogene tyrosine-protein kinase Src gene" [UniProtKB:P12931] synonym: "SRC1" EXACT [UniProtKB:P12931] xref: EMBL:AL133293 xref: EMBL:BC011566 xref: EMBL:BC051270 xref: EMBL:K03212 xref: EMBL:K03213 xref: EMBL:K03214 xref: EMBL:K03215 xref: EMBL:K03216 xref: EMBL:K03217 xref: EMBL:K03218 xref: EMBL:M16237 xref: EMBL:M16243 xref: EMBL:M16244 xref: EMBL:M16245 xref: EMBL:X02647 xref: EMBL:X03995 xref: EMBL:X03996 xref: EMBL:X03997 xref: EMBL:X03998 xref: EMBL:X03999 xref: EMBL:X04000 xref: HGNC:HGNC:11283 xref: UniGene:Hs.195659 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005464 ! SRC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005672 name: SRPRB_human def: "Signal recognition particle receptor subunit beta gene" [UniProtKB:Q9Y5M8] synonym: "PSEC0230" EXACT [UniProtKB:Q9Y5M8] xref: EMBL:AF141882 xref: EMBL:AK027525 xref: EMBL:AK075531 xref: EMBL:BC065299 xref: HGNC:HGNC:24085 xref: UniGene:Hs.584950 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006313 ! SRPRB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005673 name: SERTAD1_human def: "SERTA domain-containing protein 1 gene" [UniProtKB:Q9UHV2] synonym: "SEI1" EXACT [UniProtKB:Q9UHV2] xref: EMBL:AF117959 xref: EMBL:AF366402 xref: EMBL:AY130860 xref: EMBL:BC002670 xref: HGNC:HGNC:17932 xref: UniGene:Hs.269898 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002202 ! SRTD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005674 name: SSSCA1_human def: "Sjoegren syndrome/scleroderma autoantigen 1 gene" [UniProtKB:O60232] xref: EMBL:AB001740 xref: EMBL:BC014791 xref: HGNC:HGNC:11328 xref: UniGene:Hs.654840 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001405 ! SSA27_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005676 name: SSRP1_human def: "FACT complex subunit SSRP1 gene" [UniProtKB:Q08945] synonym: "FACT80" EXACT [UniProtKB:Q08945] xref: EMBL:BC005116 xref: EMBL:BC091486 xref: EMBL:M86737 xref: HGNC:HGNC:11327 xref: UniGene:Hs.523680 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005769 ! SSRP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005677 name: SULT1E1_human def: "Estrogen sulfotransferase gene" [UniProtKB:P49888] synonym: "STE" EXACT [UniProtKB:P49888] xref: EMBL:AY436634 xref: EMBL:BC027956 xref: EMBL:S77383 xref: EMBL:U08098 xref: EMBL:U20515 xref: EMBL:U20516 xref: EMBL:U20517 xref: EMBL:U20518 xref: EMBL:U20519 xref: EMBL:U20520 xref: EMBL:U20521 xref: EMBL:U55764 xref: EMBL:Y11195 xref: HGNC:HGNC:11377 xref: UniGene:Hs.479898 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006112 ! ST1E1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005678 name: ST5_human def: "Suppression of tumorigenicity 5 gene" [UniProtKB:P78524] synonym: "DENND2B" EXACT [UniProtKB:P78524] synonym: "HTS1" EXACT [UniProtKB:P78524] xref: EMBL:AJ400879 xref: EMBL:BC036655 xref: EMBL:S45936 xref: EMBL:U15131 xref: EMBL:U15779 xref: EMBL:U15780 xref: HGNC:HGNC:11350 xref: UniGene:Hs.117715 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006063 ! ST5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005680 name: STARD13_human def: "StAR-related lipid transfer protein 13 gene" [UniProtKB:Q9Y3M8] synonym: "DLC2" EXACT [UniProtKB:Q9Y3M8] synonym: "GT650" EXACT [UniProtKB:Q9Y3M8] xref: EMBL:AL049801 xref: EMBL:AL139187 xref: EMBL:AL627232 xref: EMBL:AY082589 xref: EMBL:AY082590 xref: EMBL:AY082591 xref: EMBL:AY366448 xref: EMBL:BC046563 xref: EMBL:BX647695 xref: EMBL:Z84483 xref: HGNC:HGNC:19164 xref: UniGene:Hs.507704 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002253 ! STA13_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005683 name: STAG1_human def: "Cohesin subunit SA-1 gene" [UniProtKB:Q8WVM7] synonym: "SA1" EXACT [UniProtKB:Q8WVM7] xref: EMBL:BC017735 xref: EMBL:Z75330 xref: HGNC:HGNC:11354 xref: UniGene:Hs.412586 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002004 ! STAG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005684 name: STAG2_human def: "Cohesin subunit SA-2 gene" [UniProtKB:Q8N3U4] synonym: "SA2" EXACT [UniProtKB:Q8N3U4] xref: EMBL:AL355476 xref: EMBL:AL831939 xref: EMBL:BC001765 xref: EMBL:Z75331 xref: HGNC:HGNC:11355 xref: UniGene:Hs.496710 xref: UniGene:Hs.624663 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001962 ! STAG2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005685 name: STAG3_human def: "Cohesin subunit SA-3 gene" [UniProtKB:Q9UJ98] xref: EMBL:AJ007798 xref: EMBL:AL833816 xref: HGNC:HGNC:11356 xref: UniGene:Hs.592283 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002209 ! STAG3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005687 name: STAT3_human def: "Signal transducer and activator of transcription 3 gene" [UniProtKB:P40763] synonym: "APRF" EXACT [UniProtKB:P40763] xref: EMBL:AF029311 xref: EMBL:AJ012463 xref: EMBL:AY572796 xref: EMBL:BC000627 xref: EMBL:BC014482 xref: EMBL:L29277 xref: HGNC:HGNC:11364 xref: UniGene:Hs.463059 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005379 ! STAT3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005688 name: STAU1_human def: "Double-stranded RNA-binding protein Staufen homolog 1 gene" [UniProtKB:O95793] synonym: "STAU" EXACT [UniProtKB:O95793] xref: EMBL:AF061938 xref: EMBL:AF061939 xref: EMBL:AF061940 xref: EMBL:AF061941 xref: EMBL:AJ132258 xref: EMBL:AL133174 xref: EMBL:AL136601 xref: EMBL:BC050432 xref: EMBL:BC095397 xref: HGNC:HGNC:11370 xref: UniGene:Hs.596704 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005483 ! STAU1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005690 name: STEAP3_human def: "Metalloreductase STEAP3 gene" [UniProtKB:Q658P3] synonym: "TSAP6" EXACT [UniProtKB:Q658P3] xref: EMBL:AC016673 xref: EMBL:AC016736 xref: EMBL:AF238864 xref: EMBL:AF262322 xref: EMBL:AF423424 xref: EMBL:AK001691 xref: EMBL:AL833624 xref: EMBL:AY029585 xref: EMBL:AY082673 xref: EMBL:AY214461 xref: EMBL:BC042150 xref: EMBL:BC095421 xref: EMBL:BX538047 xref: HGNC:HGNC:24592 xref: UniGene:Hs.647822 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001903 ! STEA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005691 name: STK11_human def: "Serine/threonine-protein kinase 11 gene" [UniProtKB:Q15831] synonym: "LKB1" EXACT [UniProtKB:Q15831] synonym: "PJS" EXACT [UniProtKB:Q15831] xref: EMBL:AF032984 xref: EMBL:AF035625 xref: EMBL:AF055320 xref: EMBL:AF055321 xref: EMBL:AF055322 xref: EMBL:AF055323 xref: EMBL:AF055324 xref: EMBL:AF055325 xref: EMBL:AF055326 xref: EMBL:AF055327 xref: EMBL:BC007981 xref: EMBL:BC019334 xref: EMBL:U63333 xref: HGNC:HGNC:11389 xref: UniGene:Hs.515005 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001814 ! STK11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005692 name: STK19_human def: "Serine/threonine-protein kinase 19 gene" [UniProtKB:P49842] synonym: "G11" EXACT [UniProtKB:P49842] synonym: "RP1" EXACT [UniProtKB:P49842] xref: EMBL:AF019413 xref: EMBL:AL049547 xref: EMBL:AL645922 xref: EMBL:AL662849 xref: EMBL:BX679671 xref: EMBL:CH471081 xref: EMBL:CR753822 xref: EMBL:L26260 xref: EMBL:L26261 xref: EMBL:U24578 xref: EMBL:X77386 xref: EMBL:X77474 xref: EMBL:X77489 xref: EMBL:X77490 xref: EMBL:X77491 xref: HGNC:HGNC:11398 xref: UniGene:Hs.654371 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005896 ! STK19_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005693 name: STK36_human def: "Serine/threonine-protein kinase 36 gene" [UniProtKB:Q9NRP7] synonym: "KIAA1278" EXACT [UniProtKB:Q9NRP7] xref: EMBL:AB033104 xref: EMBL:AF200815 xref: EMBL:AK022692 xref: EMBL:AL133630 xref: EMBL:BC026158 xref: HGNC:HGNC:17209 xref: UniGene:Hs.471404 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005375 ! STK36_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005694 name: STK4_human def: "Serine/threonine-protein kinase 4 gene" [UniProtKB:Q13043] synonym: "MST1" EXACT [UniProtKB:Q13043] xref: EMBL:AL109839 xref: EMBL:BC029511 xref: EMBL:BC058916 xref: EMBL:BC093768 xref: EMBL:U18297 xref: EMBL:U60207 xref: EMBL:Z93016 xref: HGNC:HGNC:11408 xref: UniGene:Hs.472838 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005702 ! STK4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005695 name: AURKA_human def: "Serine/threonine-protein kinase 6 gene" [UniProtKB:O14965] synonym: "AIK" EXACT [UniProtKB:O14965] synonym: "ARK1" EXACT [UniProtKB:O14965] synonym: "AURA" EXACT [UniProtKB:O14965] synonym: "BTAK" EXACT [UniProtKB:O14965] synonym: "STK15" EXACT [UniProtKB:O14965] synonym: "STK6" EXACT [UniProtKB:O14965] xref: EMBL:AF008551 xref: EMBL:AF011467 xref: EMBL:AF011468 xref: EMBL:AF195942 xref: EMBL:AF195943 xref: EMBL:AF195944 xref: EMBL:AF195945 xref: EMBL:AF195946 xref: EMBL:AF195947 xref: EMBL:AL121914 xref: EMBL:BC001280 xref: EMBL:BC002499 xref: EMBL:BC006423 xref: EMBL:BC027464 xref: EMBL:D84212 xref: HGNC:HGNC:11393 xref: UniGene:Hs.250822 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001363 ! STK6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005696 name: STMN1_human def: "Stathmin gene" [UniProtKB:P16949] synonym: "LAP18" EXACT [UniProtKB:P16949] synonym: "OP18" EXACT [UniProtKB:P16949] xref: EMBL:AL033528 xref: EMBL:BC082228 xref: EMBL:J04991 xref: EMBL:M31303 xref: EMBL:X53305 xref: EMBL:X94912 xref: EMBL:Z11566 xref: HGNC:HGNC:6510 xref: UniGene:Hs.209983 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001528 ! STMN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005697 name: STRAD_human def: "STE20-related adapter protein gene" [UniProtKB:Q7RTN6] synonym: "LYK5" EXACT [UniProtKB:Q7RTN6] xref: EMBL:AF308302 xref: EMBL:AK074771 xref: EMBL:AK075005 xref: EMBL:AY290821 xref: EMBL:BK001542 xref: UniGene:Hs.514402 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001932 ! STRAD_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005698 name: STRN3_human def: "Striatin-3 gene" [UniProtKB:Q13033] synonym: "GS2NA" EXACT [UniProtKB:Q13033] synonym: "SG2NA" EXACT [UniProtKB:Q13033] xref: EMBL:AF243424 xref: EMBL:U17989 xref: HGNC:HGNC:15720 xref: UniGene:Hs.401843 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001737 ! STRN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005699 name: STRN4_human def: "Striatin-4 gene" [UniProtKB:Q9NRL3] synonym: "ZIN" EXACT [UniProtKB:Q9NRL3] xref: EMBL:AF212940 xref: EMBL:BC004910 xref: EMBL:BC034604 xref: HGNC:HGNC:15721 xref: UniGene:Hs.631590 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006352 ! STRN4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005700 name: STX11_human def: "Syntaxin-11 gene" [UniProtKB:O75558] xref: EMBL:AF038898 xref: EMBL:AF044309 xref: EMBL:AF071504 xref: EMBL:BC033519 xref: HGNC:HGNC:11429 xref: UniGene:Hs.118958 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005220 ! STX11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005701 name: STX5_human def: "Syntaxin-5 gene" [UniProtKB:Q13190] synonym: "STX5A" EXACT [UniProtKB:Q13190] xref: EMBL:BC002645 xref: EMBL:BC012137 xref: EMBL:BT019646 xref: EMBL:BT019647 xref: EMBL:BX537426 xref: EMBL:U26648 xref: HGNC:HGNC:11440 xref: UniGene:Hs.654602 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006164 ! STX5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005702 name: SUFU_human def: "Suppressor of fused homolog gene" [UniProtKB:Q9UMX1] synonym: "UNQ650/PRO1280" EXACT [UniProtKB:Q9UMX1] xref: EMBL:AF144231 xref: EMBL:AF159447 xref: EMBL:AF172319 xref: EMBL:AF175770 xref: EMBL:AF222345 xref: EMBL:AL121928 xref: EMBL:AL137465 xref: EMBL:AL157386 xref: EMBL:AL391121 xref: EMBL:AY081818 xref: EMBL:AY081819 xref: EMBL:AY081820 xref: EMBL:AY081821 xref: EMBL:AY081822 xref: EMBL:AY081823 xref: EMBL:AY081824 xref: EMBL:AY081825 xref: EMBL:AY081826 xref: EMBL:AY081827 xref: EMBL:AY081828 xref: EMBL:AY081829 xref: EMBL:AY358550 xref: EMBL:BC013291 xref: HGNC:HGNC:16466 xref: UniGene:Hs.404089 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002232 ! SUFU_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005703 name: SUGT1_human def: "Suppressor of G2 allele of SKP1 homolog gene" [UniProtKB:Q9Y2Z0] xref: EMBL:AF132856 xref: EMBL:AJ344097 xref: EMBL:AY271314 xref: EMBL:AY321358 xref: EMBL:BC000911 xref: EMBL:BT009798 xref: HGNC:HGNC:16987 xref: UniGene:Hs.281902 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002252 ! SUGT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005704 name: SUMO1_human def: "Small ubiquitin-related modifier 1 precursor gene" [UniProtKB:P63165] synonym: "OK/SW-cl.43" EXACT [UniProtKB:P63165] synonym: "SMT3C" EXACT [UniProtKB:P63165] synonym: "SMT3H3" EXACT [UniProtKB:P63165] synonym: "UBL1" EXACT [UniProtKB:P63165] xref: EMBL:AB062294 xref: EMBL:AC079354 xref: EMBL:BC006462 xref: EMBL:BC053528 xref: EMBL:BC066306 xref: EMBL:BT006632 xref: EMBL:CR542147 xref: EMBL:CR542156 xref: EMBL:U38784 xref: EMBL:U61397 xref: EMBL:U67122 xref: EMBL:U72722 xref: EMBL:U83117 xref: EMBL:X99586 xref: HGNC:HGNC:12502 xref: UniGene:Hs.81424 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005472 ! SUMO1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005705 name: SUPT3H_human def: "Transcription initiation protein SPT3 homolog gene" [UniProtKB:O75486] synonym: "SPT3" EXACT [UniProtKB:O75486] xref: EMBL:AF064804 xref: EMBL:AF069734 xref: EMBL:AF073930 xref: HGNC:HGNC:11466 xref: UniGene:Hs.368325 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001431 ! SUPT3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005706 name: SUV39H1_human def: "Histone-lysine N-methyltransferase SUV39H1 gene" [UniProtKB:O43463] synonym: "KMT1A" EXACT [UniProtKB:O43463] synonym: "SUV39H" EXACT [UniProtKB:O43463] xref: EMBL:AF019968 xref: EMBL:AF196970 xref: EMBL:AK223071 xref: EMBL:BC006238 xref: EMBL:CR541746 xref: HGNC:HGNC:11479 xref: UniGene:Hs.522639 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001391 ! SUV91_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005707 name: SUV39H2_human def: "Histone-lysine N-methyltransferase SUV39H2 gene" [UniProtKB:Q9H5I1] synonym: "KMT1B" EXACT [UniProtKB:Q9H5I1] xref: EMBL:AC069544 xref: EMBL:AK027067 xref: EMBL:AL360083 xref: EMBL:AL834488 xref: EMBL:BC007754 xref: EMBL:BC029360 xref: EMBL:CR457372 xref: HGNC:HGNC:17287 xref: UniGene:Hs.554883 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002139 ! SUV92_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005708 name: SYCE1_human def: "Synaptonemal complex central element protein 1 gene" [UniProtKB:Q8N0S2] synonym: "C10orf94" EXACT [UniProtKB:Q8N0S2] xref: EMBL:AL161645 xref: EMBL:AY027807 xref: EMBL:AY027808 xref: EMBL:AY028079 xref: EMBL:BC034821 xref: HGNC:HGNC:28852 xref: UniGene:Hs.553795 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001960 ! SYCE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005709 name: SYCE2_human def: "Synaptonemal complex central element protein 2 gene" [UniProtKB:Q6PIF2] synonym: "CESC1" EXACT [UniProtKB:Q6PIF2] xref: EMBL:AC092069 xref: EMBL:AD000092 xref: EMBL:BC035819 xref: EMBL:CR746484 xref: HGNC:HGNC:27411 xref: UniGene:Hs.655173 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001915 ! SYCE2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005710 name: SYCP1_human def: "Synaptonemal complex protein 1 gene" [UniProtKB:Q15431] synonym: "SCP1" EXACT [UniProtKB:Q15431] xref: EMBL:AL358372 xref: EMBL:D67035 xref: EMBL:X95654 xref: HGNC:HGNC:11487 xref: UniGene:Hs.112743 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001808 ! SYCP1_HUMAN relationship: codes_for CCO:B0001900 ! Q5VXJ5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005711 name: SYCP2_human def: "Synaptonemal complex protein 2 gene" [UniProtKB:Q9BX26] synonym: "SCP2" EXACT [UniProtKB:Q9BX26] xref: EMBL:AL080226 xref: EMBL:AL109928 xref: EMBL:AL158092 xref: EMBL:Y08982 xref: HGNC:HGNC:11490 xref: UniGene:Hs.202676 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002106 ! SYCP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005712 name: SYCP3_human def: "Synaptonemal complex protein 3 gene" [UniProtKB:Q8IZU3] synonym: "SCP3" EXACT [UniProtKB:Q8IZU3] xref: EMBL:AF492003 xref: EMBL:AF517774 xref: EMBL:BC062662 xref: HGNC:HGNC:18130 xref: UniGene:Hs.506504 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001957 ! SYCP3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005714 name: KARS_human def: "Lysyl-tRNA synthetase gene" [UniProtKB:Q15046] synonym: "KIAA0070" EXACT [UniProtKB:Q15046] xref: EMBL:BC004132 xref: EMBL:D31890 xref: EMBL:D32053 xref: HGNC:HGNC:6215 xref: UniGene:Hs.3100 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006279 ! SYK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005715 name: TSC22D4_human def: "TSC22 domain family protein 4 gene" [UniProtKB:Q9Y3Q8] synonym: "TILZ2" EXACT [UniProtKB:Q9Y3Q8] xref: EMBL:AJ133115 xref: EMBL:BC001486 xref: EMBL:BC001966 xref: EMBL:BC002972 xref: EMBL:BC010406 xref: HGNC:HGNC:21696 xref: UniGene:Hs.469798 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005176 ! T22D4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005716 name: GTF2F1_human def: "General transcription factor IIF subunit 1 gene" [UniProtKB:P35269] synonym: "RAP74" EXACT [UniProtKB:P35269] xref: EMBL:BC000120 xref: EMBL:BC013007 xref: EMBL:BT007097 xref: EMBL:X64002 xref: EMBL:X64037 xref: HGNC:HGNC:4652 xref: UniGene:Hs.68257 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005354 ! T2FA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005717 name: TRAF3IP3_human def: "TRAF3-interacting JNK-activating modulator gene" [UniProtKB:Q9Y228] synonym: "T3JAM" EXACT [UniProtKB:Q9Y228] xref: EMBL:AL022398 xref: EMBL:AL049667 xref: EMBL:BC110302 xref: HGNC:HGNC:30766 xref: UniGene:Hs.147434 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006023 ! T3JAM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005718 name: TRAF4AF1_human def: "Putative TRAF4-associated factor 1 gene" [UniProtKB:Q9Y448] synonym: "C15orf23" EXACT [UniProtKB:Q9Y448] synonym: "HSD11" EXACT [UniProtKB:Q9Y448] xref: EMBL:AY652615 xref: EMBL:BC004543 xref: EMBL:BC014060 xref: EMBL:BC045739 xref: EMBL:BC064344 xref: EMBL:BC107802 xref: EMBL:BC118559 xref: EMBL:BC118639 xref: EMBL:U81002 xref: HGNC:HGNC:30767 xref: UniGene:Hs.525796 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005561 ! T4AF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005719 name: MAP3K7IP1_human def: "Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 gene" [UniProtKB:Q15750] synonym: "TAB1" EXACT [UniProtKB:Q15750] xref: EMBL:BC050554 xref: EMBL:DQ314876 xref: EMBL:U49928 xref: EMBL:Z83845 xref: HGNC:HGNC:18157 xref: UniGene:Hs.507681 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005531 ! TAB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005720 name: MAP3K7IP2_human def: "Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 gene" [UniProtKB:Q9NYJ8] synonym: "KIAA0733" EXACT [UniProtKB:Q9NYJ8] synonym: "TAB2" EXACT [UniProtKB:Q9NYJ8] xref: EMBL:AB018276 xref: EMBL:AF241230 xref: EMBL:AL031133 xref: EMBL:AL117407 xref: EMBL:AL138727 xref: EMBL:AL139103 xref: EMBL:BC035910 xref: EMBL:CR457387 xref: EMBL:DQ314877 xref: HGNC:HGNC:17075 xref: UniGene:Hs.269775 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005532 ! TAB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005721 name: TACC1_human def: "Transforming acidic coiled-coil-containing protein 1 gene" [UniProtKB:O75410] synonym: "KIAA1103" EXACT [UniProtKB:O75410] xref: EMBL:AB029026 xref: EMBL:AF049910 xref: EMBL:AY039239 xref: EMBL:AY072874 xref: EMBL:AY072875 xref: EMBL:AY072876 xref: EMBL:AY139007 xref: EMBL:AY177411 xref: EMBL:BC041391 xref: HGNC:HGNC:11522 xref: UniGene:Hs.279245 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001425 ! TACC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005722 name: TACC2_human def: "Transforming acidic coiled-coil-containing protein 2 gene" [UniProtKB:O95359] xref: EMBL:AC063960 xref: EMBL:AF095791 xref: EMBL:AF176646 xref: EMBL:AF220152 xref: EMBL:AF528098 xref: EMBL:AF528099 xref: EMBL:AL135793 xref: EMBL:AL713712 xref: EMBL:BC000999 xref: EMBL:BC039311 xref: HGNC:HGNC:11523 xref: UniGene:Hs.501252 xref: UniGene:Hs.699946 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006276 ! TACC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005723 name: TADA3L_human def: "Transcriptional adapter 3-like gene" [UniProtKB:O75528] synonym: "ADA3" EXACT [UniProtKB:O75528] xref: EMBL:AF069733 xref: EMBL:AK000228 xref: EMBL:AL117487 xref: EMBL:BC009240 xref: EMBL:BC013433 xref: HGNC:HGNC:19422 xref: UniGene:Hs.386390 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001433 ! TAD3L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005724 name: TAF10_human def: "Transcription initiation factor TFIID subunit 10 gene" [UniProtKB:Q12962] synonym: "TAF2A" EXACT [UniProtKB:Q12962] synonym: "TAF2H" EXACT [UniProtKB:Q12962] synonym: "TAFII30" EXACT [UniProtKB:Q12962] xref: EMBL:AF498312 xref: EMBL:BC012088 xref: EMBL:U13991 xref: EMBL:U25816 xref: HGNC:HGNC:11543 xref: UniGene:Hs.705378 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005937 ! TAF10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005725 name: TAF1L_human def: "Transcription initiation factor TFIID 210 kDa subunit gene" [UniProtKB:Q8IZX4] xref: EMBL:AF390562 xref: HGNC:HGNC:18056 xref: UniGene:Hs.591086 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001959 ! TAF1L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005726 name: TAF1_human def: "Transcription initiation factor TFIID subunit 1 gene" [UniProtKB:P21675] synonym: "BA2R" EXACT [UniProtKB:P21675] synonym: "CCG1" EXACT [UniProtKB:P21675] synonym: "CCGS" EXACT [UniProtKB:P21675] synonym: "TAF2A" EXACT [UniProtKB:P21675] xref: EMBL:AB209316 xref: EMBL:AJ549247 xref: EMBL:AJ549248 xref: EMBL:AJ549249 xref: EMBL:AJ549250 xref: EMBL:AJ555148 xref: EMBL:AJ555149 xref: EMBL:AM711894 xref: EMBL:AY623109 xref: EMBL:D90359 xref: EMBL:X07024 xref: HGNC:HGNC:11535 xref: UniGene:Hs.158560 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001543 ! TAF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005727 name: TAF9_human def: "Transcription initiation factor TFIID subunit 9 gene" [UniProtKB:Q16594] synonym: "TAF2G" EXACT [UniProtKB:Q16594] synonym: "TAFII31" EXACT [UniProtKB:Q16594] xref: EMBL:AY189986 xref: EMBL:BC003400 xref: EMBL:BC033320 xref: EMBL:BT019652 xref: EMBL:U21858 xref: EMBL:U25112 xref: EMBL:U30504 xref: HGNC:HGNC:11542 xref: UniGene:Hs.653163 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005938 ! TAF9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005728 name: TAK1L_human def: "TAK1-like protein gene" [UniProtKB:P57077] synonym: "C21orf7" EXACT [UniProtKB:P57077] xref: EMBL:AF269161 xref: EMBL:AF269162 xref: EMBL:AF269163 xref: EMBL:AF269164 xref: EMBL:AL163249 xref: EMBL:AY033900 xref: EMBL:AY171599 xref: EMBL:BC008567 xref: HGNC:HGNC:16457 xref: UniGene:Hs.222802 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005300 ! TAK1L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005730 name: TUBA1A_human def: "Tubulin alpha-1A chain gene" [UniProtKB:Q71U36] synonym: "TUBA3" EXACT [UniProtKB:Q71U36] xref: EMBL:AF141347 xref: EMBL:BC006468 xref: EMBL:BC050637 xref: EMBL:K00557 xref: EMBL:X01703 xref: HGNC:HGNC:20766 xref: UniGene:Hs.654422 xref: UniGene:Hs.694199 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005772 ! TBA1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005732 name: TUBA4A_human def: "Tubulin alpha-4A chain gene" [UniProtKB:P68366] synonym: "TUBA1" EXACT [UniProtKB:P68366] xref: EMBL:AY895018 xref: EMBL:BC009238 xref: EMBL:BT006731 xref: EMBL:X06956 xref: HGNC:HGNC:12407 xref: UniGene:Hs.75318 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005449 ! TBA4A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005736 name: TUBB4_human def: "Tubulin beta-4 chain gene" [UniProtKB:P04350] synonym: "TUBB5" EXACT [UniProtKB:P04350] xref: EMBL:BC006570 xref: EMBL:BC013683 xref: EMBL:X00734 xref: HGNC:HGNC:20774 xref: UniGene:Hs.110837 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006167 ! TBB4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005737 name: TUBB_human def: "Tubulin beta chain gene" [UniProtKB:P07437] synonym: "OK/SW-cl.56" EXACT [UniProtKB:P07437] synonym: "TUBB5" EXACT [UniProtKB:P07437] xref: EMBL:AB062393 xref: EMBL:AB088100 xref: EMBL:AF070561 xref: EMBL:AF070593 xref: EMBL:AF070600 xref: EMBL:AF141349 xref: EMBL:BA000025 xref: EMBL:BC001938 xref: EMBL:BC002347 xref: EMBL:BC005838 xref: EMBL:BC007605 xref: EMBL:BC013374 xref: EMBL:BC019924 xref: EMBL:BC020946 xref: EMBL:BC021909 xref: EMBL:BC070326 xref: EMBL:J00314 xref: HGNC:HGNC:20778 xref: UniGene:Hs.636480 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005727 ! TBB5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005738 name: TBC1D17_human def: "TBC1 domain family member 17 gene" [UniProtKB:Q9HA65] xref: EMBL:AK022230 xref: EMBL:BC003516 xref: HGNC:HGNC:25699 xref: UniGene:Hs.631587 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005279 ! TBC17_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005739 name: TUBE1_human def: "Tubulin epsilon chain gene" [UniProtKB:Q9UJT0] synonym: "TUBE" EXACT [UniProtKB:Q9UJT0] xref: EMBL:AF201334 xref: EMBL:BC025405 xref: EMBL:BC031101 xref: HGNC:HGNC:20775 xref: UniGene:Hs.34851 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002211 ! TBE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005740 name: TUBG1_human def: "Tubulin gamma-1 chain gene" [UniProtKB:P23258] synonym: "TUBG" EXACT [UniProtKB:P23258] xref: EMBL:BC000619 xref: EMBL:BT019931 xref: EMBL:M61764 xref: HGNC:HGNC:12417 xref: UniGene:Hs.279669 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001548 ! TBG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005741 name: TBK1_human def: "Serine/threonine-protein kinase TBK1 gene" [UniProtKB:Q9UHD2] synonym: "NAK" EXACT [UniProtKB:Q9UHD2] xref: EMBL:AF174536 xref: EMBL:AF191838 xref: EMBL:AK002192 xref: EMBL:BC034950 xref: HGNC:HGNC:11584 xref: UniGene:Hs.505874 xref: UniGene:Hs.607889 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005533 ! TBK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005742 name: TBL1XR1_human def: "F-box-like/WD repeat-containing protein TBL1XR1 gene" [UniProtKB:Q9BZK7] synonym: "IRA1" EXACT [UniProtKB:Q9BZK7] synonym: "TBLR1" EXACT [UniProtKB:Q9BZK7] xref: EMBL:AF268193 xref: EMBL:AF314544 xref: EMBL:AK022956 xref: EMBL:BC060320 xref: EMBL:BC113421 xref: HGNC:HGNC:29529 xref: UniGene:Hs.581171 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006041 ! TBL1R_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005743 name: TBL3_human def: "WD repeat-containing protein SAZD gene" [UniProtKB:Q12788] synonym: "SAZD" EXACT [UniProtKB:Q12788] xref: EMBL:U02609 xref: HGNC:HGNC:11587 xref: UniGene:Hs.513267 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006309 ! TBL3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005744 name: TBP_human def: "TATA-box-binding protein gene" [UniProtKB:P20226] synonym: "GTF2D1" EXACT [UniProtKB:P20226] synonym: "TF2D" EXACT [UniProtKB:P20226] synonym: "TFIID" EXACT [UniProtKB:P20226] xref: EMBL:AL031259 xref: EMBL:M34960 xref: EMBL:M55654 xref: EMBL:X54993 xref: HGNC:HGNC:11588 xref: UniGene:Hs.590872 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005481 ! TBP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005745 name: TBRG1_human def: "Transforming growth factor beta regulator 1 gene" [UniProtKB:Q3YBR2] synonym: "NIAM" EXACT [UniProtKB:Q3YBR2] xref: EMBL:AK027527 xref: EMBL:AK074140 xref: EMBL:AK222936 xref: EMBL:AL713631 xref: EMBL:AL831881 xref: EMBL:AY696294 xref: EMBL:BC109269 xref: EMBL:DQ144542 xref: HGNC:HGNC:29551 xref: UniGene:Hs.436410 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001832 ! TBRG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005746 name: TBRG4_human def: "Protein TBRG4 gene" [UniProtKB:Q969Z0] synonym: "CPR2" EXACT [UniProtKB:Q969Z0] synonym: "FASTKD4" EXACT [UniProtKB:Q969Z0] synonym: "KIAA0948" EXACT [UniProtKB:Q969Z0] xref: EMBL:AB023165 xref: EMBL:AF011792 xref: EMBL:AK222943 xref: EMBL:AL833840 xref: EMBL:BC002732 xref: EMBL:BC014918 xref: EMBL:BC017235 xref: HGNC:HGNC:17443 xref: UniGene:Hs.231411 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002030 ! TBRG4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005747 name: TBX3_human def: "T-box transcription factor TBX3 gene" [UniProtKB:O15119] xref: EMBL:AF002228 xref: EMBL:AF140240 xref: EMBL:AF170708 xref: EMBL:AF216750 xref: EMBL:BC025258 xref: HGNC:HGNC:11602 xref: UniGene:Hs.129895 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001365 ! TBX3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005749 name: TCP10_human def: "T-complex protein 10A homolog gene" [UniProtKB:Q12799] synonym: "TCP10A" EXACT [UniProtKB:Q12799] xref: EMBL:AL021331 xref: EMBL:AL592444 xref: EMBL:U03399 xref: HGNC:HGNC:11656 xref: UniGene:Hs.119929 xref: UniGene:Hs.351 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005617 ! TCP10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005752 name: CCT5_human def: "T-complex protein 1 subunit epsilon gene" [UniProtKB:P48643] synonym: "CCTE" EXACT [UniProtKB:P48643] synonym: "KIAA0098" EXACT [UniProtKB:P48643] xref: EMBL:BC006543 xref: EMBL:BC035499 xref: EMBL:D43950 xref: HGNC:HGNC:1618 xref: UniGene:Hs.1600 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005291 ! TCPE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005753 name: CCT3_human def: "T-complex protein 1 subunit gamma gene" [UniProtKB:P49368] synonym: "CCTG" EXACT [UniProtKB:P49368] synonym: "TRIC5" EXACT [UniProtKB:P49368] xref: EMBL:AL589685 xref: EMBL:AL833197 xref: EMBL:BC006501 xref: EMBL:BC008019 xref: EMBL:U17104 xref: EMBL:X74801 xref: HGNC:HGNC:1616 xref: UniGene:Hs.491494 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005253 ! TCPG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005755 name: TCERG1_human def: "Transcription elongation regulator 1 gene" [UniProtKB:O14776] synonym: "CA150" EXACT [UniProtKB:O14776] synonym: "TAF2S" EXACT [UniProtKB:O14776] xref: EMBL:AB209910 xref: EMBL:AF017789 xref: EMBL:BC111727 xref: HGNC:HGNC:15630 xref: UniGene:Hs.443465 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005396 ! TCRG1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005756 name: TDGF1_human def: "Teratocarcinoma-derived growth factor 1 precursor gene" [UniProtKB:P13385] synonym: "CRIPTO" EXACT [UniProtKB:P13385] xref: EMBL:M96955 xref: EMBL:X14253 xref: HGNC:HGNC:11701 xref: UniGene:Hs.385870 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006244 ! TDGF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005757 name: TDRD7_human def: "Tudor domain-containing protein 7 gene" [UniProtKB:Q8NHU6] synonym: "PCTAIRE2BP" EXACT [UniProtKB:Q8NHU6] xref: EMBL:AB025254 xref: EMBL:AL122110 xref: EMBL:AL449464 xref: EMBL:AL512590 xref: EMBL:BC028694 xref: HGNC:HGNC:30831 xref: UniGene:Hs.193842 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005496 ! TDRD7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005758 name: TERF2IP_human def: "Telomeric repeat-binding factor 2-interacting protein 1 gene" [UniProtKB:Q9NYB0] synonym: "PP8000" EXACT [UniProtKB:Q9NYB0] synonym: "RAP1" EXACT [UniProtKB:Q9NYB0] xref: EMBL:AF262988 xref: EMBL:AF289599 xref: EMBL:AK000669 xref: EMBL:BC004465 xref: EMBL:BC005841 xref: EMBL:BC022428 xref: EMBL:BC078171 xref: HGNC:HGNC:19246 xref: UniGene:Hs.301419 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005505 ! TE2IP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005759 name: TCAP_human def: "Telethonin gene" [UniProtKB:O15273] xref: EMBL:AJ000491 xref: EMBL:AJ010063 xref: EMBL:AJ011098 xref: EMBL:BC012628 xref: EMBL:BC013330 xref: HGNC:HGNC:11610 xref: UniGene:Hs.514146 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005387 ! TELT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005760 name: TERF1_human def: "Telomeric repeat-binding factor 1 gene" [UniProtKB:P54274] synonym: "PIN2" EXACT [UniProtKB:P54274] synonym: "TRBF1" EXACT [UniProtKB:P54274] synonym: "TRF" EXACT [UniProtKB:P54274] synonym: "TRF1" EXACT [UniProtKB:P54274] xref: EMBL:AF003001 xref: EMBL:U40705 xref: EMBL:U70992 xref: EMBL:U70993 xref: EMBL:U74382 xref: EMBL:X93511 xref: HGNC:HGNC:11728 xref: UniGene:Hs.442707 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001667 ! TERF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005761 name: TERF2_human def: "Telomeric repeat-binding factor 2 gene" [UniProtKB:Q15554] synonym: "TRBF2" EXACT [UniProtKB:Q15554] synonym: "TRF2" EXACT [UniProtKB:Q15554] xref: EMBL:AF002999 xref: EMBL:BC024890 xref: EMBL:U95970 xref: EMBL:X93512 xref: HGNC:HGNC:11729 xref: UniGene:Hs.63335 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001810 ! TERF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005762 name: TEX11_human def: "Testis-expressed sequence 11 protein gene" [UniProtKB:Q8IYF3] xref: EMBL:AF285594 xref: EMBL:AK057391 xref: EMBL:AK057523 xref: EMBL:AL139109 xref: EMBL:AL627071 xref: EMBL:AL627390 xref: EMBL:BC036016 xref: HGNC:HGNC:11733 xref: UniGene:Hs.121776 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005187 ! TEX11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005763 name: GTF2H1_human def: "General transcription factor IIH subunit 1 gene" [UniProtKB:P32780] synonym: "BTF2" EXACT [UniProtKB:P32780] xref: EMBL:AJ131959 xref: EMBL:AK027003 xref: EMBL:AY163770 xref: EMBL:BC000365 xref: EMBL:BC004452 xref: EMBL:M95809 xref: HGNC:HGNC:4655 xref: UniGene:Hs.577202 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001585 ! TF2H1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005764 name: GTF3C1_human def: "General transcription factor 3C polypeptide 1 gene" [UniProtKB:Q12789] xref: EMBL:AC002303 xref: EMBL:AC002551 xref: EMBL:BC044857 xref: EMBL:U02619 xref: EMBL:U06485 xref: HGNC:HGNC:4664 xref: UniGene:Hs.371718 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006211 ! TF3C1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005765 name: RELA_human def: "Transcription factor p65 gene" [UniProtKB:Q04206] synonym: "NFKB3" EXACT [UniProtKB:Q04206] xref: EMBL:AY455868 xref: EMBL:BC033522 xref: EMBL:L19067 xref: EMBL:M62399 xref: EMBL:Z22948 xref: EMBL:Z22949 xref: EMBL:Z22950 xref: EMBL:Z22951 xref: EMBL:Z22953 xref: HGNC:HGNC:9955 xref: UniGene:Hs.502875 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005865 ! TF65_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005768 name: TFDP1_human def: "Transcription factor Dp-1 gene" [UniProtKB:Q14186] synonym: "DP1" EXACT [UniProtKB:Q14186] xref: EMBL:AF550129 xref: EMBL:AL442125 xref: EMBL:BC011685 xref: EMBL:CH471085 xref: EMBL:L23959 xref: HGNC:HGNC:11749 xref: UniGene:Hs.79353 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001776 ! TFDP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005769 name: TFDP2_human def: "Transcription factor Dp-2 gene" [UniProtKB:Q14188] synonym: "DP2" EXACT [UniProtKB:Q14188] xref: EMBL:AY509596 xref: EMBL:BC021113 xref: EMBL:L40386 xref: EMBL:U18422 xref: EMBL:U35117 xref: EMBL:U75488 xref: HGNC:HGNC:11751 xref: UniGene:Hs.379018 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001777 ! TFDP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005771 name: TCF3_human def: "Transcription factor E2-alpha gene" [UniProtKB:P15923] synonym: "E2A" EXACT [UniProtKB:P15923] synonym: "ITF1" EXACT [UniProtKB:P15923] xref: EMBL:AC005321 xref: EMBL:AC006274 xref: EMBL:M24404 xref: EMBL:M24405 xref: EMBL:M31222 xref: EMBL:M31522 xref: EMBL:M31523 xref: EMBL:M65214 xref: EMBL:X52078 xref: HGNC:HGNC:11633 xref: UniGene:Hs.371282 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006057 ! TFE2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005772 name: TGFA_human def: "Protransforming growth factor alpha precursor gene" [UniProtKB:P01135] xref: EMBL:AF123238 xref: EMBL:AF123239 xref: EMBL:AF123240 xref: EMBL:AF123241 xref: EMBL:AF123242 xref: EMBL:AF123243 xref: EMBL:K03222 xref: EMBL:M22440 xref: EMBL:M31172 xref: EMBL:X70340 xref: HGNC:HGNC:11765 xref: UniGene:Hs.170009 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005870 ! TGFA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005773 name: TGFB1_human def: "Transforming growth factor beta-1 precursor gene" [UniProtKB:P01137] synonym: "TGFB" EXACT [UniProtKB:P01137] xref: EMBL:BC000125 xref: EMBL:BC001180 xref: EMBL:BC022242 xref: EMBL:BT007245 xref: EMBL:M38449 xref: EMBL:X02812 xref: EMBL:X05839 xref: EMBL:X05840 xref: EMBL:X05843 xref: EMBL:X05844 xref: EMBL:X05849 xref: EMBL:X05850 xref: HGNC:HGNC:11766 xref: UniGene:Hs.645227 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001471 ! TGFB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005774 name: TGFB2_human def: "Transforming growth factor beta-2 precursor gene" [UniProtKB:P61812] xref: EMBL:AY438979 xref: EMBL:BC096235 xref: EMBL:BC099635 xref: EMBL:M19154 xref: EMBL:M87843 xref: EMBL:Y00083 xref: HGNC:HGNC:11768 xref: UniGene:Hs.133379 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001687 ! TGFB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005777 name: TGIF1_human def: "Homeobox protein TGIF1 gene" [UniProtKB:Q15583] synonym: "TGIF" EXACT [UniProtKB:Q15583] xref: EMBL:AF179900 xref: EMBL:BC000814 xref: EMBL:BC031268 xref: EMBL:CR450333 xref: EMBL:X89750 xref: HGNC:HGNC:11776 xref: UniGene:Hs.373550 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006246 ! TGIF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005778 name: THAP8_human def: "THAP domain-containing protein 8 gene" [UniProtKB:Q8NA92] xref: EMBL:AK057453 xref: EMBL:AK093048 xref: EMBL:BC072416 xref: HGNC:HGNC:23191 xref: UniGene:Hs.350209 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006304 ! THAP8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005779 name: TXN_human def: "Thioredoxin gene" [UniProtKB:P10599] synonym: "TRDX" EXACT [UniProtKB:P10599] synonym: "TRX" EXACT [UniProtKB:P10599] synonym: "TRX1" EXACT [UniProtKB:P10599] xref: EMBL:AF276919 xref: EMBL:AF313911 xref: EMBL:AF548001 xref: EMBL:AY004872 xref: EMBL:BC003377 xref: EMBL:BC054866 xref: EMBL:J04026 xref: EMBL:X54539 xref: EMBL:X54540 xref: EMBL:X54541 xref: EMBL:X77584 xref: HGNC:HGNC:12435 xref: UniGene:Hs.435136 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005808 ! THIO_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005781 name: TRIM28_human def: "Transcription intermediary factor 1-beta gene" [UniProtKB:Q13263] synonym: "KAP1" EXACT [UniProtKB:Q13263] synonym: "RNF96" EXACT [UniProtKB:Q13263] synonym: "TIF1B" EXACT [UniProtKB:Q13263] xref: EMBL:BC004978 xref: EMBL:BC007390 xref: EMBL:BC052986 xref: EMBL:U31657 xref: EMBL:U78773 xref: EMBL:U95040 xref: EMBL:X97548 xref: HGNC:HGNC:16384 xref: UniGene:Hs.467408 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005585 ! TIF1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005782 name: TIMELESS_human def: "Protein timeless homolog gene" [UniProtKB:Q9UNS1] synonym: "TIM" EXACT [UniProtKB:Q9UNS1] synonym: "TIM1" EXACT [UniProtKB:Q9UNS1] synonym: "TIMELESS1" EXACT [UniProtKB:Q9UNS1] xref: EMBL:AB015597 xref: EMBL:AF098162 xref: EMBL:BC039842 xref: EMBL:BC050557 xref: HGNC:HGNC:11813 xref: UniGene:Hs.118631 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002235 ! TIM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005783 name: TINF2_human def: "TERF1-interacting nuclear factor 2 gene" [UniProtKB:Q9BSI4] synonym: "TIN2" EXACT [UniProtKB:Q9BSI4] xref: EMBL:AF195512 xref: EMBL:AK023166 xref: EMBL:BC005030 xref: EMBL:BC019343 xref: HGNC:HGNC:11824 xref: UniGene:Hs.496191 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006245 ! TINF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005784 name: HTATIP_human def: "Histone acetyltransferase HTATIP gene" [UniProtKB:Q92993] synonym: "TIP60" EXACT [UniProtKB:Q92993] xref: EMBL:AY214165 xref: EMBL:BC000166 xref: EMBL:BC064912 xref: EMBL:BC117167 xref: EMBL:U40989 xref: EMBL:U67734 xref: EMBL:U74667 xref: HGNC:HGNC:5275 xref: UniGene:Hs.528299 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005351 ! TIP60_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005785 name: TIPIN_human def: "TIMELESS-interacting protein gene" [UniProtKB:Q9BVW5] xref: EMBL:AK000523 xref: EMBL:BC000870 xref: EMBL:BK001386 xref: EMBL:CH471082 xref: HGNC:HGNC:30750 xref: UniGene:Hs.572318 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002104 ! TIPIN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005786 name: TTN_human def: "Titin gene" [UniProtKB:Q8WZ42] xref: EMBL:AF058332 xref: EMBL:AF525413 xref: EMBL:AJ277892 xref: EMBL:AL713647 xref: EMBL:BC013396 xref: EMBL:BC058824 xref: EMBL:BC070170 xref: EMBL:BC107797 xref: EMBL:DQ248309 xref: EMBL:X64697 xref: EMBL:X64698 xref: EMBL:X64699 xref: EMBL:X69490 xref: EMBL:X83270 xref: EMBL:X90568 xref: EMBL:X90569 xref: EMBL:X98114 xref: EMBL:X98115 xref: HGNC:HGNC:12403 xref: UniGene:Hs.654592 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002013 ! TITIN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005788 name: TLE1_human def: "Transducin-like enhancer protein 1 gene" [UniProtKB:Q04724] xref: EMBL:AL353682 xref: EMBL:AL365190 xref: EMBL:BC010100 xref: EMBL:BC015747 xref: EMBL:M99435 xref: HGNC:HGNC:11837 xref: UniGene:Hs.197320 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005511 ! TLE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005789 name: TLE2_human def: "Transducin-like enhancer protein 2 gene" [UniProtKB:Q04725] xref: EMBL:AC007766 xref: EMBL:AC011549 xref: EMBL:BC017364 xref: EMBL:M99436 xref: HGNC:HGNC:11838 xref: UniGene:Hs.332173 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005657 ! TLE2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005790 name: TLE3_human def: "Transducin-like enhancer protein 3 gene" [UniProtKB:Q04726] synonym: "KIAA1547" EXACT [UniProtKB:Q04726] xref: EMBL:AB046767 xref: EMBL:BC015729 xref: EMBL:BC041831 xref: EMBL:M99438 xref: HGNC:HGNC:11839 xref: UniGene:Hs.287362 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005690 ! TLE3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005791 name: TLK1_human def: "Serine/threonine-protein kinase tousled-like 1 gene" [UniProtKB:Q9UKI8] synonym: "KIAA0137" EXACT [UniProtKB:Q9UKI8] xref: EMBL:AB004885 xref: EMBL:AF162666 xref: EMBL:AF246219 xref: EMBL:BC032657 xref: EMBL:D50927 xref: HGNC:HGNC:11841 xref: UniGene:Hs.655640 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002220 ! TLK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005792 name: TLK2_human def: "Serine/threonine-protein kinase tousled-like 2 gene" [UniProtKB:Q86UE8] xref: EMBL:AB004884 xref: EMBL:AF162667 xref: EMBL:BC044925 xref: HGNC:HGNC:11842 xref: UniGene:Hs.445078 xref: UniGene:Hs.633264 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001939 ! TLK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005793 name: TMPRSS11A_human def: "Transmembrane protease, serine 11A gene" [UniProtKB:Q6ZMR5] synonym: "ECRG1" EXACT [UniProtKB:Q6ZMR5] synonym: "HATL1" EXACT [UniProtKB:Q6ZMR5] synonym: "HESP" EXACT [UniProtKB:Q6ZMR5] xref: EMBL:AF071882 xref: EMBL:AK131518 xref: EMBL:AY498712 xref: EMBL:BC111796 xref: EMBL:BN000133 xref: HGNC:HGNC:27954 xref: UniGene:Hs.450110 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001922 ! TM11A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005795 name: TOM1L1_human def: "TOM1-like protein 1 gene" [UniProtKB:O75674] synonym: "SRCASM" EXACT [UniProtKB:O75674] xref: EMBL:AJ010071 xref: HGNC:HGNC:11983 xref: UniGene:Hs.153504 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006203 ! TM1L1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005796 name: TMF1_human def: "TATA element modulatory factor gene" [UniProtKB:P82094] xref: EMBL:L01042 xref: HGNC:HGNC:11870 xref: UniGene:Hs.267632 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005984 ! TMF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005800 name: TNIK_human def: "TRAF2 and NCK-interacting protein kinase gene" [UniProtKB:Q9UKE5] synonym: "KIAA0551" EXACT [UniProtKB:Q9UKE5] xref: EMBL:AB011123 xref: EMBL:AF172264 xref: EMBL:AF172265 xref: EMBL:AF172266 xref: EMBL:AF172267 xref: EMBL:AF172268 xref: EMBL:AF172269 xref: EMBL:AF172270 xref: EMBL:AF172271 xref: EMBL:BC019081 xref: HGNC:HGNC:30765 xref: UniGene:Hs.34024 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005603 ! TNIK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005801 name: TNPO1_human def: "Transportin-1 gene" [UniProtKB:Q92973] synonym: "KPNB2" EXACT [UniProtKB:Q92973] synonym: "MIP1" EXACT [UniProtKB:Q92973] synonym: "TRN" EXACT [UniProtKB:Q92973] xref: EMBL:BC040340 xref: EMBL:U70322 xref: EMBL:U72069 xref: EMBL:U72395 xref: HGNC:HGNC:6401 xref: UniGene:Hs.482497 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005663 ! TNPO1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005803 name: TNFRSF1A_human def: "Tumor necrosis factor receptor superfamily member 1A precursor gene" [UniProtKB:P19438] synonym: "TNFAR" EXACT [UniProtKB:P19438] synonym: "TNFR1" EXACT [UniProtKB:P19438] xref: EMBL:A21522 xref: EMBL:AY131997 xref: EMBL:BC010140 xref: EMBL:M33294 xref: EMBL:M58286 xref: EMBL:M60275 xref: EMBL:M63121 xref: EMBL:M75864 xref: EMBL:M75865 xref: EMBL:M75866 xref: EMBL:X55313 xref: HGNC:HGNC:11916 xref: UniGene:Hs.279594 xref: UniGene:Hs.705365 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005534 ! TNR1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005804 name: TNFRSF1B_human def: "Tumor necrosis factor receptor superfamily member 1B precursor gene" [UniProtKB:P20333] synonym: "TNFBR" EXACT [UniProtKB:P20333] synonym: "TNFR2" EXACT [UniProtKB:P20333] xref: EMBL:AB030950 xref: EMBL:AL031276 xref: EMBL:AL357835 xref: EMBL:AY148473 xref: EMBL:AY264804 xref: EMBL:AY342040 xref: EMBL:BC052977 xref: EMBL:BT019927 xref: EMBL:M32315 xref: EMBL:M35857 xref: EMBL:M55994 xref: EMBL:S63368 xref: EMBL:U52156 xref: EMBL:U52157 xref: EMBL:U52158 xref: EMBL:U52159 xref: EMBL:U52160 xref: EMBL:U52161 xref: EMBL:U52162 xref: EMBL:U52163 xref: EMBL:U52164 xref: EMBL:U52165 xref: HGNC:HGNC:11917 xref: UniGene:Hs.256278 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005535 ! TNR1B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005805 name: FAS_human def: "Tumor necrosis factor receptor superfamily member 6 precursor gene" [UniProtKB:P25445] synonym: "APT1" EXACT [UniProtKB:P25445] synonym: "FAS1" EXACT [UniProtKB:P25445] synonym: "TNFRSF6" EXACT [UniProtKB:P25445] xref: EMBL:AY450925 xref: EMBL:BC012479 xref: EMBL:M67454 xref: EMBL:X63717 xref: EMBL:X83490 xref: EMBL:X83491 xref: EMBL:X83492 xref: EMBL:X83493 xref: EMBL:X89101 xref: EMBL:Z47993 xref: EMBL:Z47994 xref: EMBL:Z47995 xref: EMBL:Z70519 xref: EMBL:Z70520 xref: HGNC:HGNC:11920 xref: UniGene:Hs.244139 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005479 ! TNR6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005806 name: TNFRSF8_human def: "Tumor necrosis factor receptor superfamily member 8 precursor gene" [UniProtKB:P28908] synonym: "CD30" EXACT [UniProtKB:P28908] synonym: "D1S166E" EXACT [UniProtKB:P28908] xref: EMBL:AJ289159 xref: EMBL:AY498860 xref: EMBL:D86042 xref: EMBL:M83554 xref: EMBL:S75768 xref: HGNC:HGNC:11923 xref: UniGene:Hs.1314 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006010 ! TNR8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005808 name: TOLLIP_human def: "Toll-interacting protein gene" [UniProtKB:Q9H0E2] xref: EMBL:AJ242972 xref: EMBL:AK022871 xref: EMBL:AL136835 xref: EMBL:BC004420 xref: EMBL:BC012057 xref: EMBL:BC018272 xref: HGNC:HGNC:16476 xref: UniGene:Hs.368527 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005273 ! TOLIP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005810 name: TOP1_human def: "DNA topoisomerase 1 gene" [UniProtKB:P11387] xref: EMBL:AL022394 xref: EMBL:AL035652 xref: EMBL:J03250 xref: EMBL:M27913 xref: EMBL:M60688 xref: EMBL:M60689 xref: EMBL:M60690 xref: EMBL:M60691 xref: EMBL:M60692 xref: EMBL:M60693 xref: EMBL:M60694 xref: EMBL:M60695 xref: EMBL:M60696 xref: EMBL:M60697 xref: EMBL:M60698 xref: EMBL:M60699 xref: EMBL:M60700 xref: EMBL:M60701 xref: EMBL:M60702 xref: EMBL:M60703 xref: EMBL:M60704 xref: EMBL:M60705 xref: EMBL:M60706 xref: EMBL:U07804 xref: EMBL:U07806 xref: EMBL:X16479 xref: EMBL:X52601 xref: HGNC:HGNC:11986 xref: UniGene:Hs.472737 xref: UniGene:Hs.592136 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005587 ! TOP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005812 name: TOP3A_human def: "DNA topoisomerase 3-alpha gene" [UniProtKB:Q13472] synonym: "TOP3" EXACT [UniProtKB:Q13472] xref: EMBL:BC051748 xref: EMBL:U43431 xref: HGNC:HGNC:11992 xref: UniGene:Hs.592115 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001753 ! TOP3A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005813 name: PBK_human def: "Lymphokine-activated killer T-cell-originated protein kinase gene" [UniProtKB:Q96KB5] synonym: "TOPK" EXACT [UniProtKB:Q96KB5] xref: EMBL:AB027249 xref: EMBL:AB027250 xref: EMBL:AF189722 xref: EMBL:AF237709 xref: EMBL:AK027291 xref: EMBL:BC015191 xref: HGNC:HGNC:18282 xref: UniGene:Hs.104741 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002045 ! TOPK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005814 name: PTP4A1_human def: "Protein tyrosine phosphatase type IVA 1 gene" [UniProtKB:Q93096] synonym: "PRL1" EXACT [UniProtKB:Q93096] synonym: "PTPCAAX1" EXACT [UniProtKB:Q93096] xref: EMBL:AF051160 xref: EMBL:AL135905 xref: EMBL:BC023975 xref: EMBL:BC045571 xref: EMBL:CR749458 xref: EMBL:U48296 xref: EMBL:U69701 xref: HGNC:HGNC:9634 xref: UniGene:Hs.227777 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002029 ! TP4A1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005815 name: TP53BP1_human def: "Tumor suppressor p53-binding protein 1 gene" [UniProtKB:Q12888] xref: EMBL:AB210025 xref: EMBL:AF078776 xref: EMBL:AY904026 xref: EMBL:BC112161 xref: EMBL:BX537418 xref: EMBL:U09477 xref: HGNC:HGNC:11999 xref: UniGene:Hs.440968 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005412 ! TP53B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005816 name: TPD52_human def: "Tumor protein D52 gene" [UniProtKB:P55327] xref: EMBL:BC018117 xref: EMBL:S82081 xref: EMBL:U18914 xref: HGNC:HGNC:12005 xref: UniGene:Hs.368433 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005373 ! TPD52_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005817 name: TPD52L1_human def: "Tumor protein D53 gene" [UniProtKB:Q16890] xref: EMBL:AF004427 xref: EMBL:U44427 xref: EMBL:U44428 xref: HGNC:HGNC:12006 xref: UniGene:Hs.591347 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001825 ! TPD53_HUMAN relationship: codes_for CCO:B0005643 ! O43397_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005818 name: TPD52L3_human def: "Tumor protein D55 gene" [UniProtKB:Q96J77] xref: EMBL:AK057479 xref: EMBL:AL133480 xref: EMBL:AY032877 xref: EMBL:BC017589 xref: EMBL:BC033792 xref: EMBL:BC042113 xref: HGNC:HGNC:23382 xref: UniGene:Hs.351815 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005918 ! TPD55_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005819 name: TPX2_human def: "Targeting protein for Xklp2 gene" [UniProtKB:Q9ULW0] synonym: "C20orf1" EXACT [UniProtKB:Q9ULW0] synonym: "C20orf2" EXACT [UniProtKB:Q9ULW0] synonym: "DIL2" EXACT [UniProtKB:Q9ULW0] synonym: "HCA519" EXACT [UniProtKB:Q9ULW0] xref: EMBL:AB024704 xref: EMBL:AB027467 xref: EMBL:AF098158 xref: EMBL:AF146731 xref: EMBL:AF244547 xref: EMBL:AL117534 xref: EMBL:AL160175 xref: EMBL:BC004136 xref: EMBL:BC020207 xref: HGNC:HGNC:1249 xref: UniGene:Hs.244580 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002227 ! TPX2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005820 name: AD-001_human def: "TRM112-like protein gene" [UniProtKB:Q9UI30] synonym: "HSPC152" EXACT [UniProtKB:Q9UI30] synonym: "HSPC170" EXACT [UniProtKB:Q9UI30] xref: EMBL:AF110774 xref: EMBL:AF161501 xref: EMBL:AF229068 xref: EMBL:BC017172 xref: EMBL:BC029482 xref: EMBL:BC105294 xref: UniGene:Hs.333579 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005568 ! TR112_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005822 name: TRAF1_human def: "TNF receptor-associated factor 1 gene" [UniProtKB:Q13077] synonym: "EBI6" EXACT [UniProtKB:Q13077] xref: EMBL:AK090468 xref: EMBL:BC024145 xref: EMBL:BT019408 xref: EMBL:U19261 xref: HGNC:HGNC:12031 xref: UniGene:Hs.531251 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005992 ! TRAF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005823 name: TRAF2_human def: "TNF receptor-associated factor 2 gene" [UniProtKB:Q12933] synonym: "TRAP3" EXACT [UniProtKB:Q12933] xref: EMBL:AK054686 xref: EMBL:AY623660 xref: EMBL:BC032410 xref: EMBL:BC033810 xref: EMBL:BC043492 xref: EMBL:BC064662 xref: EMBL:U12597 xref: HGNC:HGNC:12032 xref: UniGene:Hs.522506 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005170 ! TRAF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005824 name: TRAF6_human def: "TNF receptor-associated factor 6 gene" [UniProtKB:Q9Y4K3] synonym: "RNF85" EXACT [UniProtKB:Q9Y4K3] xref: EMBL:AY228337 xref: EMBL:BC031052 xref: EMBL:U78798 xref: HGNC:HGNC:12036 xref: UniGene:Hs.591983 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005536 ! TRAF6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005826 name: TRDMT1_human def: "tRNA (cytosine-5-)-methyltransferase gene" [UniProtKB:O14717] synonym: "DNMT2" EXACT [UniProtKB:O14717] xref: EMBL:AC067747 xref: EMBL:AF012128 xref: EMBL:AF045888 xref: EMBL:AF329940 xref: EMBL:AF329941 xref: EMBL:AF329942 xref: EMBL:AF329943 xref: EMBL:AF329944 xref: EMBL:AJ223333 xref: EMBL:AL133415 xref: HGNC:HGNC:2977 xref: UniGene:Hs.351665 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006138 ! TRDMT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005827 name: TRIM13_human def: "Tripartite motif-containing protein 13 gene" [UniProtKB:O60858] synonym: "LEU5" EXACT [UniProtKB:O60858] synonym: "RFP2" EXACT [UniProtKB:O60858] synonym: "RNF77" EXACT [UniProtKB:O60858] xref: EMBL:AF220127 xref: EMBL:AF220128 xref: EMBL:AF241849 xref: EMBL:AF241850 xref: EMBL:AF279660 xref: EMBL:AJ224819 xref: EMBL:AL137060 xref: EMBL:AY191002 xref: EMBL:AY455758 xref: EMBL:BC003579 xref: EMBL:BC063407 xref: HGNC:HGNC:9976 xref: UniGene:Hs.436922 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001416 ! TRI13_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005828 name: TRIM27_human def: "Zinc finger protein RFP gene" [UniProtKB:P14373] synonym: "RFP" EXACT [UniProtKB:P14373] synonym: "RNF76" EXACT [UniProtKB:P14373] xref: EMBL:AF230393 xref: EMBL:AF230394 xref: EMBL:AL662859 xref: EMBL:AL662871 xref: EMBL:BC013580 xref: EMBL:BC066924 xref: EMBL:BX000360 xref: EMBL:BX537153 xref: EMBL:J03407 xref: EMBL:Z84474 xref: EMBL:Z84476 xref: HGNC:HGNC:9975 xref: UniGene:Hs.440382 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005981 ! TRI27_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005829 name: TRIM29_human def: "Tripartite motif-containing protein 29 gene" [UniProtKB:Q14134] synonym: "ATDC" EXACT [UniProtKB:Q14134] xref: EMBL:AF230388 xref: EMBL:AF230389 xref: EMBL:BC017352 xref: EMBL:L24203 xref: HGNC:HGNC:17274 xref: UniGene:Hs.504115 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005204 ! TRI29_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005830 name: TRIM37_human def: "Tripartite motif-containing protein 37 gene" [UniProtKB:O94972] synonym: "KIAA0898" EXACT [UniProtKB:O94972] synonym: "MUL" EXACT [UniProtKB:O94972] synonym: "POB1" EXACT [UniProtKB:O94972] xref: EMBL:AB020705 xref: EMBL:AF213365 xref: EMBL:BC036012 xref: EMBL:BX537955 xref: HGNC:HGNC:7523 xref: UniGene:Hs.579079 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005249 ! TRI37_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005831 name: TRIAP1_human def: "TP53-regulated inhibitor of apoptosis 1 gene" [UniProtKB:O43715] synonym: "15E1.1" EXACT [UniProtKB:O43715] synonym: "HSPC132" EXACT [UniProtKB:O43715] xref: EMBL:AF161481 xref: EMBL:AL021546 xref: EMBL:BC002638 xref: EMBL:BC055313 xref: EMBL:U75688 xref: HGNC:HGNC:26937 xref: UniGene:Hs.69499 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001398 ! TRIA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005833 name: TRIB3_human def: "Tribbles homolog 3 gene" [UniProtKB:Q96RU7] synonym: "C20orf97" EXACT [UniProtKB:Q96RU7] synonym: "NIPK" EXACT [UniProtKB:Q96RU7] synonym: "SKIP3" EXACT [UniProtKB:Q96RU7] synonym: "TRB3" EXACT [UniProtKB:Q96RU7] xref: EMBL:AF250311 xref: EMBL:AJ697936 xref: EMBL:AK026945 xref: EMBL:AK222837 xref: EMBL:AL034548 xref: EMBL:AY247738 xref: EMBL:BC019363 xref: EMBL:BC027484 xref: EMBL:CR457366 xref: HGNC:HGNC:16228 xref: UniGene:Hs.516826 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005477 ! TRIB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005834 name: MID2_human def: "Midline-2 gene" [UniProtKB:Q9UJV3] synonym: "FXY2" EXACT [UniProtKB:Q9UJV3] synonym: "RNF60" EXACT [UniProtKB:Q9UJV3] synonym: "TRIM1" EXACT [UniProtKB:Q9UJV3] xref: EMBL:AF196481 xref: EMBL:AL034399 xref: EMBL:AL109946 xref: EMBL:BC017707 xref: EMBL:BT006663 xref: EMBL:Y18880 xref: HGNC:HGNC:7096 xref: UniGene:Hs.12256 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005969 ! TRIM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005835 name: TRIP6_human def: "Thyroid receptor-interacting protein 6 gene" [UniProtKB:Q15654] synonym: "OIP1" EXACT [UniProtKB:Q15654] xref: EMBL:AF000974 xref: EMBL:AF093834 xref: EMBL:AF093835 xref: EMBL:AF093836 xref: EMBL:AF312032 xref: EMBL:AJ001902 xref: EMBL:BC002680 xref: EMBL:BC004249 xref: EMBL:BC004999 xref: EMBL:BC021540 xref: EMBL:BC028985 xref: EMBL:L40374 xref: HGNC:HGNC:12311 xref: UniGene:Hs.534360 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005985 ! TRIP6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005836 name: TRIP13_human def: "Thyroid receptor-interacting protein 13 gene" [UniProtKB:Q15645] xref: EMBL:BC000404 xref: EMBL:BC019294 xref: EMBL:CR456744 xref: EMBL:L40384 xref: EMBL:U96131 xref: HGNC:HGNC:12307 xref: UniGene:Hs.436187 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006283 ! TRP13_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005837 name: TRRAP_human def: "Transformation/transcription domain-associated protein gene" [UniProtKB:Q9Y4A5] synonym: "PAF400" EXACT [UniProtKB:Q9Y4A5] xref: EMBL:AC004893 xref: EMBL:AC004991 xref: EMBL:AF076974 xref: EMBL:AF110377 xref: HGNC:HGNC:12347 xref: UniGene:Hs.203952 xref: UniGene:Hs.657548 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005350 ! TRRAP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005838 name: TSG101_human def: "Tumor susceptibility gene 101 protein gene" [UniProtKB:Q99816] xref: EMBL:BC002487 xref: EMBL:U82130 xref: HGNC:HGNC:15971 xref: UniGene:Hs.523512 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005283 ! TS101_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005839 name: TSC1_human def: "Hamartin gene" [UniProtKB:Q92574] synonym: "KIAA0243" EXACT [UniProtKB:Q92574] synonym: "TSC" EXACT [UniProtKB:Q92574] xref: EMBL:AC002096 xref: EMBL:AF013168 xref: EMBL:AF234185 xref: EMBL:D87683 xref: HGNC:HGNC:12362 xref: UniGene:Hs.370854 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002014 ! TSC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005840 name: TSC2_human def: "Tuberin gene" [UniProtKB:P49815] synonym: "TSC4" EXACT [UniProtKB:P49815] xref: EMBL:AB014460 xref: EMBL:AC005600 xref: EMBL:BC025364 xref: EMBL:BC046929 xref: EMBL:L48517 xref: EMBL:L48518 xref: EMBL:L48519 xref: EMBL:L48521 xref: EMBL:L48522 xref: EMBL:L48523 xref: EMBL:L48524 xref: EMBL:L48525 xref: EMBL:L48526 xref: EMBL:L48527 xref: EMBL:L48528 xref: EMBL:L48529 xref: EMBL:L48530 xref: EMBL:L48531 xref: EMBL:L48532 xref: EMBL:L48533 xref: EMBL:L48534 xref: EMBL:L48535 xref: EMBL:L48536 xref: EMBL:L48537 xref: EMBL:L48538 xref: EMBL:L48539 xref: EMBL:L48540 xref: EMBL:L48541 xref: EMBL:L48542 xref: EMBL:L48543 xref: EMBL:L48544 xref: EMBL:L48545 xref: EMBL:L48546 xref: EMBL:X75621 xref: HGNC:HGNC:12363 xref: UniGene:Hs.90303 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001637 ! TSC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005841 name: TSPYL2_human def: "Testis-specific Y-encoded-like protein 2 gene" [UniProtKB:Q9H2G4] synonym: "CDA1" EXACT [UniProtKB:Q9H2G4] synonym: "DENTT" EXACT [UniProtKB:Q9H2G4] synonym: "HRIHFB2216" EXACT [UniProtKB:Q9H2G4] synonym: "TSPX" EXACT [UniProtKB:Q9H2G4] xref: EMBL:AB015345 xref: EMBL:AF254794 xref: EMBL:AF273046 xref: EMBL:AL713652 xref: EMBL:AY040871 xref: EMBL:BC001566 xref: EMBL:BC024270 xref: EMBL:BX322635 xref: HGNC:HGNC:24358 xref: UniGene:Hs.136164 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002128 ! TSYL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005842 name: TTK_human def: "Dual specificity protein kinase TTK gene" [UniProtKB:P33981] synonym: "MPS1L1" EXACT [UniProtKB:P33981] xref: EMBL:AL133475 xref: EMBL:BC000633 xref: EMBL:BC032858 xref: EMBL:CH471051 xref: EMBL:M86699 xref: EMBL:X70500 xref: HGNC:HGNC:12401 xref: UniGene:Hs.169840 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001587 ! TTK_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005843 name: TTLL5_human def: "Tubulin polyglutamylase TTLL5 gene" [UniProtKB:Q6EMB2] synonym: "KIAA0998" EXACT [UniProtKB:Q6EMB2] synonym: "STAMP" EXACT [UniProtKB:Q6EMB2] xref: EMBL:AB023215 xref: EMBL:AC007182 xref: EMBL:AC009399 xref: EMBL:AF107885 xref: EMBL:AY237126 xref: HGNC:HGNC:19963 xref: UniGene:Hs.532626 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006333 ! TTLL5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005844 name: TUSC2_human def: "Tumor suppressor candidate 2 gene" [UniProtKB:O75896] synonym: "FUS1" EXACT [UniProtKB:O75896] synonym: "LGCC" EXACT [UniProtKB:O75896] synonym: "PDAP2" EXACT [UniProtKB:O75896] xref: EMBL:AF055479 xref: EMBL:BC023976 xref: HGNC:HGNC:17034 xref: UniGene:Hs.517981 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001438 ! TUSC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005845 name: TUSC4_human def: "Tumor suppressor candidate 4 gene" [UniProtKB:Q8WTW4] synonym: "NPRL2" EXACT [UniProtKB:Q8WTW4] xref: EMBL:AC002481 xref: EMBL:AF040707 xref: EMBL:AF040708 xref: EMBL:BC021984 xref: EMBL:BC056861 xref: HGNC:HGNC:24969 xref: UniGene:Hs.437083 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002000 ! TUSC4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005846 name: TXNDC11_human def: "Thioredoxin domain-containing protein 11 gene" [UniProtKB:Q6PKC3] synonym: "EFP1" EXACT [UniProtKB:Q6PKC3] xref: EMBL:AF131780 xref: EMBL:AK027464 xref: EMBL:AK027646 xref: EMBL:AK074534 xref: EMBL:BC002856 xref: EMBL:BC013727 xref: EMBL:BC018635 xref: EMBL:CR457152 xref: HGNC:HGNC:28030 xref: UniGene:Hs.313847 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005993 ! TXD11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005847 name: TXNL4A_human def: "Thioredoxin-like protein 4A gene" [UniProtKB:P83876] synonym: "DIM1" EXACT [UniProtKB:P83876] synonym: "TXNL4" EXACT [UniProtKB:P83876] xref: EMBL:AF023611 xref: EMBL:AF023612 xref: EMBL:AF146373 xref: EMBL:BC001046 xref: EMBL:BC019272 xref: EMBL:CH471117 xref: HGNC:HGNC:30551 xref: UniGene:Hs.465498 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001361 ! O14835_HUMAN relationship: codes_for CCO:B0001702 ! TXN4A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005848 name: TXNL4B_human def: "Thioredoxin-like protein 4B gene" [UniProtKB:Q9NX01] synonym: "DIM2" EXACT [UniProtKB:Q9NX01] synonym: "DLP" EXACT [UniProtKB:Q9NX01] xref: EMBL:AK000518 xref: EMBL:AY566808 xref: EMBL:BC009646 xref: EMBL:CR457240 xref: HGNC:HGNC:26041 xref: UniGene:Hs.134406 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002172 ! TXN4B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005849 name: TXNIP_human def: "Thioredoxin-interacting protein gene" [UniProtKB:Q9H3M7] synonym: "VDUP1" EXACT [UniProtKB:Q9H3M7] xref: EMBL:AB051901 xref: EMBL:AF333001 xref: EMBL:AL138842 xref: EMBL:AL160282 xref: EMBL:AY594328 xref: EMBL:BC093702 xref: EMBL:BC093704 xref: EMBL:S73591 xref: HGNC:HGNC:16952 xref: UniGene:Hs.533977 xref: UniGene:Hs.702728 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002133 ! TXNIP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005850 name: TMSB4X_human def: "Thymosin beta-4 gene" [UniProtKB:P62328] synonym: "TB4X" EXACT [UniProtKB:P62328] synonym: "THYB4" EXACT [UniProtKB:P62328] synonym: "TMSB4" EXACT [UniProtKB:P62328] xref: EMBL:AJ295158 xref: EMBL:BT007090 xref: EMBL:M17733 xref: EMBL:X02493 xref: HGNC:HGNC:11881 xref: UniGene:Hs.522584 xref: UniGene:Hs.699565 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006115 ! TYB4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005851 name: YY1_human def: "Transcriptional repressor protein YY1 gene" [UniProtKB:P25490] xref: EMBL:BC037308 xref: EMBL:BC065366 xref: EMBL:M76541 xref: EMBL:M77698 xref: EMBL:Z14077 xref: HGNC:HGNC:12856 xref: UniGene:Hs.388927 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006011 ! TYY1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005852 name: BAT1_human def: "Spliceosome RNA helicase BAT1 gene" [UniProtKB:Q13838] synonym: "UAP56" EXACT [UniProtKB:Q13838] xref: EMBL:AB088115 xref: EMBL:AB103621 xref: EMBL:AB202112 xref: EMBL:AF029061 xref: EMBL:AF029062 xref: EMBL:AK222912 xref: EMBL:AL662801 xref: EMBL:AL662847 xref: EMBL:BA000025 xref: EMBL:BC000361 xref: EMBL:BC013006 xref: EMBL:BT009909 xref: EMBL:BX001040 xref: EMBL:BX248516 xref: EMBL:Z37166 xref: HGNC:HGNC:13917 xref: UniGene:Hs.254042 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005899 ! UAP56_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005853 name: CDC34_human def: "Ubiquitin-conjugating enzyme E2 R1 gene" [UniProtKB:P49427] synonym: "UBE2R1" EXACT [UniProtKB:P49427] xref: EMBL:AY650399 xref: EMBL:BC009850 xref: EMBL:BC018143 xref: EMBL:BC023979 xref: EMBL:BT006659 xref: EMBL:L22005 xref: HGNC:HGNC:1734 xref: UniGene:Hs.514997 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001628 ! UB2R1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005855 name: UBE2V2_human def: "Ubiquitin-conjugating enzyme E2 variant 2 gene" [UniProtKB:Q15819] synonym: "MMS2" EXACT [UniProtKB:Q15819] synonym: "UEV2" EXACT [UniProtKB:Q15819] xref: EMBL:AF049140 xref: EMBL:BC007051 xref: EMBL:BC016332 xref: EMBL:BC016710 xref: EMBL:BC028673 xref: EMBL:BC062418 xref: EMBL:BT006744 xref: EMBL:CR407628 xref: EMBL:U62136 xref: EMBL:X98091 xref: HGNC:HGNC:12495 xref: UniGene:Hs.491695 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001813 ! UB2V2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005857 name: UBE2M_human def: "NEDD8-conjugating enzyme Ubc12 gene" [UniProtKB:P61081] synonym: "UBC12" EXACT [UniProtKB:P61081] xref: EMBL:AB012191 xref: EMBL:AF075599 xref: EMBL:BC058924 xref: EMBL:BT006754 xref: HGNC:HGNC:12491 xref: UniGene:Hs.406068 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005329 ! UBC12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005858 name: UBE2I_human def: "SUMO-conjugating enzyme UBC9 gene" [UniProtKB:P63279] synonym: "UBC9" EXACT [UniProtKB:P63279] synonym: "UBCE9" EXACT [UniProtKB:P63279] xref: EMBL:AB208988 xref: EMBL:AE006466 xref: EMBL:AJ002385 xref: EMBL:AL031714 xref: EMBL:BC000427 xref: EMBL:BC004429 xref: EMBL:BC051289 xref: EMBL:BT006932 xref: EMBL:D45050 xref: EMBL:U29092 xref: EMBL:U31882 xref: EMBL:U31933 xref: EMBL:U38785 xref: EMBL:U45328 xref: EMBL:U66818 xref: EMBL:U66867 xref: EMBL:X96427 xref: HGNC:HGNC:12485 xref: UniGene:Hs.302903 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001696 ! UBC9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005859 name: UBLCP1_human def: "Ubiquitin-like domain-containing CTD phosphatase 1 gene" [UniProtKB:Q8WVY7] xref: EMBL:AK057996 xref: EMBL:AY444562 xref: EMBL:BC013425 xref: HGNC:HGNC:28110 xref: UniGene:Hs.591733 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005278 ! UBCP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005860 name: UBE2C_human def: "Ubiquitin-conjugating enzyme E2 C gene" [UniProtKB:O00762] synonym: "UBCH10" EXACT [UniProtKB:O00762] xref: EMBL:AL050348 xref: EMBL:BC007656 xref: EMBL:BC016292 xref: EMBL:BC050736 xref: EMBL:BT007300 xref: EMBL:U73379 xref: HGNC:HGNC:15937 xref: UniGene:Hs.93002 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001354 ! UBE2C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005862 name: UBE3A_human def: "Ubiquitin-protein ligase E3A gene" [UniProtKB:Q05086] synonym: "E6AP" EXACT [UniProtKB:Q05086] synonym: "EPVE6AP" EXACT [UniProtKB:Q05086] synonym: "HPVE6A" EXACT [UniProtKB:Q05086] xref: EMBL:AF016703 xref: EMBL:AF016704 xref: EMBL:AF016705 xref: EMBL:AF016706 xref: EMBL:AF016707 xref: EMBL:AF016708 xref: EMBL:AJ001107 xref: EMBL:AJ001108 xref: EMBL:AJ001109 xref: EMBL:AJ001110 xref: EMBL:AJ001111 xref: EMBL:AJ001112 xref: EMBL:L07557 xref: EMBL:U84404 xref: EMBL:X98021 xref: EMBL:X98022 xref: EMBL:X98023 xref: EMBL:X98024 xref: EMBL:X98025 xref: EMBL:X98026 xref: EMBL:X98027 xref: EMBL:X98028 xref: EMBL:X98029 xref: EMBL:X98030 xref: EMBL:X98031 xref: EMBL:X98032 xref: EMBL:X98033 xref: HGNC:HGNC:12496 xref: UniGene:Hs.654383 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005334 ! UBE3A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005863 name: RPS27A_human def: "Ubiquitin gene" [UniProtKB:P62988] synonym: "UBA80" EXACT [UniProtKB:P62988] synonym: "UBCEP1" EXACT [UniProtKB:P62988] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001695 ! UBIQ_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005864 name: UBA52_human def: "Ubiquitin gene" [UniProtKB:P62988] synonym: "UBCEP2" EXACT [UniProtKB:P62988] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001695 ! UBIQ_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005865 name: UBB_human def: "Ubiquitin gene" [UniProtKB:P62988] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001695 ! UBIQ_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005866 name: UBC_human def: "Ubiquitin gene" [UniProtKB:P62988] is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001695 ! UBIQ_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005867 name: UBL5_human def: "Ubiquitin-like protein 5 gene" [UniProtKB:Q9BZL1] xref: EMBL:AF313915 xref: EMBL:BC007053 xref: EMBL:BC110839 xref: EMBL:BT007355 xref: HGNC:HGNC:13736 xref: UniGene:Hs.534477 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005932 ! UBL5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005868 name: USP16_human def: "Ubiquitin carboxyl-terminal hydrolase 16 gene" [UniProtKB:Q9Y5T5] xref: EMBL:AF126736 xref: EMBL:AL163249 xref: EMBL:BC030777 xref: HGNC:HGNC:12614 xref: UniGene:Hs.99819 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002259 ! UBP16_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005869 name: USP4_human def: "Ubiquitin carboxyl-terminal hydrolase 4 gene" [UniProtKB:Q13107] synonym: "UNP" EXACT [UniProtKB:Q13107] synonym: "UNPH" EXACT [UniProtKB:Q13107] xref: EMBL:AF017305 xref: EMBL:AF017306 xref: EMBL:BC125130 xref: EMBL:U20657 xref: HGNC:HGNC:12627 xref: UniGene:Hs.631919 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006305 ! UBP4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005871 name: USP7_human def: "Ubiquitin carboxyl-terminal hydrolase 7 gene" [UniProtKB:Q93009] synonym: "HAUSP" EXACT [UniProtKB:Q93009] xref: EMBL:Z72499 xref: HGNC:HGNC:12630 xref: UniGene:Hs.386939 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005429 ! UBP7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005872 name: UBQLN1_human def: "Ubiquilin-1 gene" [UniProtKB:Q9UMX0] synonym: "DA41" EXACT [UniProtKB:Q9UMX0] synonym: "PLIC1" EXACT [UniProtKB:Q9UMX0] xref: EMBL:AB035275 xref: EMBL:AF176069 xref: EMBL:AF293384 xref: EMBL:AK074535 xref: EMBL:AL136643 xref: EMBL:BC010066 xref: EMBL:BC039294 xref: HGNC:HGNC:12508 xref: UniGene:Hs.9589 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005181 ! UBQL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005873 name: UBQLN4_human def: "Ubiquilin-4 gene" [UniProtKB:Q9NRR5] synonym: "C1orf6" EXACT [UniProtKB:Q9NRR5] synonym: "UBIN" EXACT [UniProtKB:Q9NRR5] xref: EMBL:AF113544 xref: EMBL:AF188240 xref: EMBL:BC006410 xref: EMBL:BC018403 xref: EMBL:BC063841 xref: HGNC:HGNC:1237 xref: UniGene:Hs.283739 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005619 ! UBQL4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005874 name: UBR1_human def: "E3 ubiquitin-protein ligase UBR1 gene" [UniProtKB:Q8IWV7] xref: EMBL:AF061556 xref: EMBL:AF067380 xref: EMBL:AF067381 xref: EMBL:AF067382 xref: EMBL:AF067383 xref: EMBL:AF067384 xref: EMBL:AF067385 xref: EMBL:AF067386 xref: EMBL:AF067387 xref: EMBL:AF525401 xref: EMBL:AK027803 xref: EMBL:AY061886 xref: EMBL:BC113505 xref: EMBL:BC113507 xref: EMBL:CR749326 xref: HGNC:HGNC:16808 xref: UniGene:Hs.591121 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006135 ! UBR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005875 name: UCHL1_human def: "Ubiquitin carboxyl-terminal hydrolase isozyme L1 gene" [UniProtKB:P09936] xref: EMBL:AF060834 xref: EMBL:AF076269 xref: EMBL:AF076270 xref: EMBL:AF076271 xref: EMBL:AF076272 xref: EMBL:AF076273 xref: EMBL:BC000332 xref: EMBL:BC005117 xref: EMBL:BC006305 xref: EMBL:X04741 xref: EMBL:X17377 xref: HGNC:HGNC:12513 xref: UniGene:Hs.518731 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005541 ! UCHL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005878 name: UHMK1_human def: "Serine/threonine-protein kinase Kist gene" [UniProtKB:Q8TAS1] synonym: "KIS" EXACT [UniProtKB:Q8TAS1] synonym: "KIST" EXACT [UniProtKB:Q8TAS1] xref: EMBL:AJ536197 xref: EMBL:AL359699 xref: EMBL:BC014917 xref: EMBL:BC026046 xref: HGNC:HGNC:19683 xref: UniGene:Hs.127310 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001988 ! UHMK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005879 name: UHRF1_human def: "E3 ubiquitin-protein ligase UHRF1 gene" [UniProtKB:Q96T88] synonym: "ICBP90" EXACT [UniProtKB:Q96T88] synonym: "NP95" EXACT [UniProtKB:Q96T88] synonym: "RNF106" EXACT [UniProtKB:Q96T88] xref: EMBL:AB075601 xref: EMBL:AC027319 xref: EMBL:AC053467 xref: EMBL:AF129507 xref: EMBL:AF274048 xref: EMBL:AK025578 xref: EMBL:AY787925 xref: HGNC:HGNC:12556 xref: UniGene:Hs.108106 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002063 ! UHRF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005880 name: UHRF2_human def: "E3 ubiquitin-protein ligase UHRF2 gene" [UniProtKB:Q96PU4] synonym: "NIRF" EXACT [UniProtKB:Q96PU4] synonym: "RNF107" EXACT [UniProtKB:Q96PU4] xref: EMBL:AB071698 xref: EMBL:AF274049 xref: EMBL:AL133480 xref: EMBL:AL137728 xref: EMBL:AL353718 xref: EMBL:BC028397 xref: HGNC:HGNC:12557 xref: UniGene:Hs.493401 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002054 ! UHRF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005882 name: ULK2_human def: "Serine/threonine-protein kinase ULK2 gene" [UniProtKB:Q8IYT8] synonym: "KIAA0623" EXACT [UniProtKB:Q8IYT8] xref: EMBL:AB014523 xref: EMBL:BC034988 xref: HGNC:HGNC:13480 xref: UniGene:Hs.168762 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006252 ! ULK2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005883 name: UNC119_human def: "Protein unc-119 homolog gene" [UniProtKB:Q13432] synonym: "RG4" EXACT [UniProtKB:Q13432] xref: EMBL:AF028788 xref: EMBL:AF028789 xref: EMBL:AF125997 xref: EMBL:AF125998 xref: EMBL:BC027176 xref: EMBL:U40998 xref: HGNC:HGNC:12565 xref: UniGene:Hs.410455 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006080 ! UN119_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005884 name: UNC84B_human def: "Protein unc-84 homolog B gene" [UniProtKB:Q9UH99] synonym: "FRIGG" EXACT [UniProtKB:Q9UH99] synonym: "KIAA0668" EXACT [UniProtKB:Q9UH99] synonym: "RAB5IP" EXACT [UniProtKB:Q9UH99] synonym: "SUN2" EXACT [UniProtKB:Q9UH99] xref: EMBL:AB014568 xref: EMBL:AF202723 xref: EMBL:AL021707 xref: EMBL:AY682988 xref: EMBL:BC030684 xref: EMBL:BC111717 xref: EMBL:BX537962 xref: EMBL:CR456474 xref: HGNC:HGNC:14210 xref: UniGene:Hs.517622 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002199 ! UN84B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005886 name: URM1_human def: "Ubiquitin-related modifier 1 homolog gene" [UniProtKB:Q9BTM9] synonym: "C9orf74" EXACT [UniProtKB:Q9BTM9] xref: EMBL:AL359091 xref: EMBL:BC003581 xref: HGNC:HGNC:28378 xref: UniGene:Hs.495229 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006312 ! URM1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005887 name: USHBP1_human def: "USH1C-binding protein 1 gene" [UniProtKB:Q8N6Y0] synonym: "AIEBP" EXACT [UniProtKB:Q8N6Y0] synonym: "MCC2" EXACT [UniProtKB:Q8N6Y0] xref: EMBL:AB026290 xref: EMBL:AB040046 xref: EMBL:AK075162 xref: EMBL:BC027910 xref: HGNC:HGNC:24058 xref: UniGene:Hs.512773 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005210 ! USBP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005888 name: USH1C_human def: "Harmonin gene" [UniProtKB:Q9Y6N9] synonym: "AIE75" EXACT [UniProtKB:Q9Y6N9] xref: EMBL:AB006955 xref: EMBL:AB018687 xref: EMBL:AF039699 xref: EMBL:AF039700 xref: EMBL:BC016057 xref: HGNC:HGNC:12597 xref: UniGene:Hs.502072 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002265 ! USH1C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005889 name: UTP14A_human def: "U3 small nucleolar RNA-associated protein 14 homolog A gene" [UniProtKB:Q9BVJ6] synonym: "SDCCAG16" EXACT [UniProtKB:Q9BVJ6] xref: EMBL:AL034405 xref: EMBL:BC001149 xref: EMBL:BC009649 xref: EMBL:BC014987 xref: HGNC:HGNC:10665 xref: UniGene:Hs.458598 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006134 ! UT14A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005890 name: UTP14C_human def: "U3 small nucleolar RNA-associated protein 14 homolog C gene" [UniProtKB:Q5TAP6] synonym: "KIAA0266" EXACT [UniProtKB:Q5TAP6] xref: EMBL:AL139082 xref: EMBL:BC089407 xref: EMBL:D87455 xref: HGNC:HGNC:20321 xref: UniGene:Hs.512963 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001882 ! UT14C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005891 name: UTP6_human def: "U3 small nucleolar RNA-associated protein 6 homolog gene" [UniProtKB:Q9NYH9] synonym: "C17orf40" EXACT [UniProtKB:Q9NYH9] synonym: "HCA66" EXACT [UniProtKB:Q9NYH9] synonym: "MHAT" EXACT [UniProtKB:Q9NYH9] xref: EMBL:AF244135 xref: EMBL:AF334386 xref: EMBL:AJ272197 xref: EMBL:BC015454 xref: EMBL:BC035325 xref: HGNC:HGNC:18279 xref: UniGene:Hs.589862 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006050 ! UTP6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005892 name: VAMP8_human def: "Vesicle-associated membrane protein 8 gene" [UniProtKB:Q9BV40] xref: EMBL:AC016753 xref: EMBL:AF053233 xref: EMBL:BC001634 xref: EMBL:BT006700 xref: EMBL:CR456995 xref: HGNC:HGNC:12647 xref: UniGene:Hs.534373 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006350 ! VAMP8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005893 name: VASH1_human def: "Vasohibin-1 gene" [UniProtKB:Q7L8A9] synonym: "KIAA1036" EXACT [UniProtKB:Q7L8A9] synonym: "VASH" EXACT [UniProtKB:Q7L8A9] xref: EMBL:AB028959 xref: EMBL:AC007376 xref: EMBL:AF111169 xref: EMBL:AL832588 xref: EMBL:BC009031 xref: EMBL:BC051896 xref: HGNC:HGNC:19964 xref: UniGene:Hs.525479 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001931 ! VASH1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005894 name: VDAC1_human def: "Voltage-dependent anion-selective channel protein 1 gene" [UniProtKB:P21796] synonym: "VDAC" EXACT [UniProtKB:P21796] xref: EMBL:AC005200 xref: EMBL:AC008608 xref: EMBL:AF151093 xref: EMBL:AF151094 xref: EMBL:AF151095 xref: EMBL:AF151096 xref: EMBL:AF151097 xref: EMBL:AJ250032 xref: EMBL:AJ250033 xref: EMBL:AJ250034 xref: EMBL:AJ250035 xref: EMBL:AJ250036 xref: EMBL:AJ250037 xref: EMBL:AJ250038 xref: EMBL:AJ250039 xref: EMBL:BC008482 xref: EMBL:BC071168 xref: EMBL:BC090042 xref: EMBL:L06132 xref: HGNC:HGNC:12669 xref: UniGene:Hs.519320 xref: UniGene:Hs.644647 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005765 ! VDAC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005895 name: VDAC2_human def: "Voltage-dependent anion-selective channel protein 2 gene" [UniProtKB:P45880] xref: EMBL:AF152220 xref: EMBL:AF152221 xref: EMBL:AF152222 xref: EMBL:AF152223 xref: EMBL:AF152224 xref: EMBL:AF152225 xref: EMBL:AF152226 xref: EMBL:AF152227 xref: EMBL:AL390034 xref: EMBL:AL392111 xref: EMBL:BC000165 xref: EMBL:BC012883 xref: EMBL:BC072407 xref: EMBL:CR456964 xref: EMBL:L06328 xref: EMBL:L08666 xref: HGNC:HGNC:12672 xref: UniGene:Hs.355927 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005777 ! VDAC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005896 name: VDAC3_human def: "Voltage-dependent anion-selective channel protein 3 gene" [UniProtKB:Q9Y277] xref: EMBL:AF038962 xref: EMBL:AF151679 xref: EMBL:AF151681 xref: EMBL:AF151682 xref: EMBL:BC056870 xref: EMBL:U90943 xref: HGNC:HGNC:12674 xref: UniGene:Hs.655340 xref: UniGene:Hs.699301 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005738 ! VDAC3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005902 name: VHL_human def: "Von Hippel-Lindau disease tumor suppressor gene" [UniProtKB:P40337] xref: EMBL:AF010238 xref: EMBL:L15409 xref: EMBL:U54612 xref: EMBL:X96489 xref: HGNC:HGNC:12687 xref: UniGene:Hs.517792 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001600 ! VHL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005903 name: VIM_human def: "Vimentin gene" [UniProtKB:P08670] xref: EMBL:AF328728 xref: EMBL:AK056766 xref: EMBL:AK097336 xref: EMBL:AK222507 xref: EMBL:AK222602 xref: EMBL:AK290643 xref: EMBL:AL133415 xref: EMBL:BC000163 xref: EMBL:BC030573 xref: EMBL:BC066956 xref: EMBL:CH471072 xref: EMBL:CR407690 xref: EMBL:M14144 xref: EMBL:M18888 xref: EMBL:M18889 xref: EMBL:M18890 xref: EMBL:M18891 xref: EMBL:M18892 xref: EMBL:M18893 xref: EMBL:M18894 xref: EMBL:M18895 xref: EMBL:M25246 xref: EMBL:X16478 xref: EMBL:X56134 xref: EMBL:Z19554 xref: HGNC:HGNC:12692 xref: UniGene:Hs.642813 xref: UniGene:Hs.704019 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005737 ! VIME_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005904 name: VSNL1_human def: "Visinin-like protein 1 gene" [UniProtKB:P62760] synonym: "VISL1" EXACT [UniProtKB:P62760] xref: EMBL:AB001104 xref: EMBL:AF039555 xref: EMBL:BC022012 xref: EMBL:U14747 xref: HGNC:HGNC:12722 xref: UniGene:Hs.444212 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005986 ! VISL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005905 name: VPS29_human def: "Vacuolar protein sorting-associated protein 29 gene" [UniProtKB:Q9UBQ0] synonym: "DC15" EXACT [UniProtKB:Q9UBQ0] synonym: "DC7" EXACT [UniProtKB:Q9UBQ0] synonym: "MDS007" EXACT [UniProtKB:Q9UBQ0] xref: EMBL:AF168716 xref: EMBL:AF175264 xref: EMBL:AF193795 xref: EMBL:AF201936 xref: EMBL:AF201946 xref: EMBL:AL136614 xref: EMBL:BC000880 xref: EMBL:BC095446 xref: HGNC:HGNC:14340 xref: UniGene:Hs.632735 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006299 ! VPS29_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005906 name: VPS72_human def: "Vacuolar protein sorting-associated protein 72 homolog gene" [UniProtKB:Q15906] synonym: "TCFL1" EXACT [UniProtKB:Q15906] synonym: "YL1" EXACT [UniProtKB:Q15906] xref: EMBL:AK222935 xref: EMBL:AK222939 xref: EMBL:AL592424 xref: EMBL:BC003151 xref: EMBL:BT019356 xref: EMBL:BT019357 xref: EMBL:CH471121 xref: EMBL:D43642 xref: HGNC:HGNC:11644 xref: UniGene:Hs.2430 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005361 ! VPS72_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005908 name: VTA1_human def: "Vacuolar protein sorting-associated protein VTA1 homolog gene" [UniProtKB:Q9NP79] synonym: "C6orf55" EXACT [UniProtKB:Q9NP79] synonym: "HSPC228" EXACT [UniProtKB:Q9NP79] synonym: "My012" EXACT [UniProtKB:Q9NP79] xref: EMBL:AF060225 xref: EMBL:AF151062 xref: EMBL:AF271994 xref: EMBL:AK000051 xref: EMBL:AL033522 xref: EMBL:AL136684 xref: EMBL:BC005937 xref: EMBL:BC006989 xref: EMBL:BC022536 xref: EMBL:CR457207 xref: HGNC:HGNC:20954 xref: UniGene:Hs.431367 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005259 ! VTA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005909 name: GC_human def: "Vitamin D-binding protein precursor gene" [UniProtKB:P02774] xref: EMBL:L10641 xref: EMBL:M12654 xref: EMBL:M17156 xref: EMBL:S67474 xref: EMBL:S67476 xref: EMBL:S67478 xref: EMBL:S67479 xref: EMBL:S67480 xref: EMBL:S67526 xref: EMBL:S77129 xref: EMBL:S77130 xref: EMBL:X03178 xref: HGNC:HGNC:4187 xref: UniGene:Hs.418497 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006193 ! VTDB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005910 name: WAPAL_human def: "Wings apart-like protein homolog gene" [UniProtKB:Q7Z5K2] synonym: "FOE" EXACT [UniProtKB:Q7Z5K2] synonym: "KIAA0261" EXACT [UniProtKB:Q7Z5K2] synonym: "WAPL" EXACT [UniProtKB:Q7Z5K2] xref: EMBL:AB065003 xref: EMBL:AF479418 xref: EMBL:AL731569 xref: EMBL:AL844892 xref: EMBL:D87450 xref: HGNC:HGNC:23293 xref: UniGene:Hs.203099 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005721 ! WAPL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005913 name: WBP2NL_human def: "Postacrosomal sheath WW domain-binding protein gene" [UniProtKB:Q6ICG8] synonym: "PAWP" EXACT [UniProtKB:Q6ICG8] xref: EMBL:AF393575 xref: EMBL:BC022546 xref: EMBL:BC022549 xref: EMBL:CR456400 xref: EMBL:Z99716 xref: HGNC:HGNC:28389 xref: UniGene:Hs.655541 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001907 ! WBP2L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005914 name: WBP2_human def: "WW domain-binding protein 2 gene" [UniProtKB:Q969T9] xref: EMBL:BC007452 xref: EMBL:BC010616 xref: EMBL:U79458 xref: HGNC:HGNC:12738 xref: UniGene:Hs.514489 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006351 ! WBP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005915 name: WBP7_human def: "WW domain-binding protein 7 gene" [UniProtKB:Q9UMN6] synonym: "HRX2" EXACT [UniProtKB:Q9UMN6] synonym: "KIAA0304" EXACT [UniProtKB:Q9UMN6] synonym: "KMT2D" EXACT [UniProtKB:Q9UMN6] synonym: "MLL2" EXACT [UniProtKB:Q9UMN6] synonym: "MLL4" EXACT [UniProtKB:Q9UMN6] synonym: "TRX2" EXACT [UniProtKB:Q9UMN6] xref: EMBL:AB002302 xref: EMBL:AD000671 xref: EMBL:AF104918 xref: EMBL:AF105279 xref: EMBL:AF105280 xref: EMBL:AF186605 xref: EMBL:AJ007041 xref: EMBL:BC007353 xref: EMBL:BC009337 xref: UniGene:Hs.676457 xref: UniGene:Hs.92236 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006032 ! WBP7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005916 name: WDR51B_human def: "WD repeat-containing protein 51B gene" [UniProtKB:Q8TC44] xref: EMBL:AK074772 xref: EMBL:BC026080 xref: HGNC:HGNC:30836 xref: UniGene:Hs.705416 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005998 ! WD51B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005917 name: WDR26_human def: "WD repeat-containing protein 26 gene" [UniProtKB:Q9H7D7] synonym: "CDW2" EXACT [UniProtKB:Q9H7D7] synonym: "MIP2" EXACT [UniProtKB:Q9H7D7] synonym: "PRO0852" EXACT [UniProtKB:Q9H7D7] xref: EMBL:AB209887 xref: EMBL:AF130049 xref: EMBL:AK024669 xref: EMBL:AY221751 xref: EMBL:AY304473 xref: EMBL:BC031471 xref: EMBL:BC034498 xref: EMBL:BC052301 xref: EMBL:BC063817 xref: EMBL:EF011612 xref: HGNC:HGNC:21208 xref: UniGene:Hs.497873 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005689 ! WDR26_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005918 name: WDR33_human def: "WD repeat-containing protein 33 gene" [UniProtKB:Q9C0J8] synonym: "WDC146" EXACT [UniProtKB:Q9C0J8] xref: EMBL:AB044749 xref: HGNC:HGNC:25651 xref: UniGene:Hs.620490 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006169 ! WDR33_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005919 name: WDR35_human def: "WD repeat-containing protein 35 gene" [UniProtKB:Q9P2L0] synonym: "KIAA1336" EXACT [UniProtKB:Q9P2L0] xref: EMBL:AB037757 xref: EMBL:BC036659 xref: HGNC:HGNC:29250 xref: UniGene:Hs.205427 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006025 ! WDR35_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005920 name: WDR47_human def: "WD repeat-containing protein 47 gene" [UniProtKB:O94967] synonym: "KIAA0893" EXACT [UniProtKB:O94967] xref: EMBL:AB020700 xref: EMBL:BC034964 xref: EMBL:BC039254 xref: HGNC:HGNC:29141 xref: UniGene:Hs.654760 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006319 ! WDR47_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005921 name: WDR57_human def: "WD repeat-containing protein 57 gene" [UniProtKB:Q96DI7] synonym: "PRP8BP" EXACT [UniProtKB:Q96DI7] synonym: "SFP38" EXACT [UniProtKB:Q96DI7] xref: EMBL:AC114495 xref: EMBL:AF083383 xref: EMBL:AF090988 xref: EMBL:AL451070 xref: EMBL:BC001494 xref: HGNC:HGNC:30857 xref: UniGene:Hs.33962 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005996 ! WDR57_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005922 name: WDR5B_human def: "WD repeat-containing protein 5B gene" [UniProtKB:Q86VZ2] xref: EMBL:AK002149 xref: EMBL:BC043494 xref: EMBL:CR457279 xref: HGNC:HGNC:17826 xref: UniGene:Hs.567513 xref: UniGene:Hs.594258 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006000 ! WDR5B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005923 name: WDR5_human def: "WD repeat-containing protein 5 gene" [UniProtKB:P61964] synonym: "BIG3" EXACT [UniProtKB:P61964] xref: EMBL:AJ011376 xref: EMBL:AK000552 xref: EMBL:BC001635 xref: HGNC:HGNC:12757 xref: UniGene:Hs.397638 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005615 ! WDR5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005924 name: WDR61_human def: "WD repeat-containing protein 61 gene" [UniProtKB:Q9GZS3] xref: EMBL:AF100786 xref: EMBL:AF127799 xref: EMBL:AF309553 xref: EMBL:AK024754 xref: EMBL:BC010080 xref: EMBL:CR457333 xref: HGNC:HGNC:30300 xref: UniGene:Hs.513055 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005999 ! WDR61_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005925 name: WDR62_human def: "WD repeat-containing protein 62 gene" [UniProtKB:O43379] synonym: "C19orf14" EXACT [UniProtKB:O43379] xref: EMBL:AC004144 xref: EMBL:AD000813 xref: EMBL:AK090617 xref: EMBL:AL133651 xref: EMBL:BC017261 xref: EMBL:BX647726 xref: HGNC:HGNC:24502 xref: UniGene:Hs.116244 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006173 ! WDR62_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005926 name: WDR74_human def: "WD repeat-containing protein 74 gene" [UniProtKB:Q6RFH5] synonym: "NSA1" EXACT [UniProtKB:Q6RFH5] xref: EMBL:AK001301 xref: EMBL:AK025383 xref: EMBL:AY500828 xref: EMBL:BC006351 xref: HGNC:HGNC:25529 xref: UniGene:Hs.654620 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006296 ! WDR74_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005927 name: WDR76_human def: "WD repeat-containing protein 76 gene" [UniProtKB:Q9H967] xref: EMBL:AK023035 xref: EMBL:BC051855 xref: HGNC:HGNC:25773 xref: UniGene:Hs.250154 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005997 ! WDR76_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005928 name: WDR82_human def: "WD repeat-containing protein 82 gene" [UniProtKB:Q6UXN9] synonym: "UNQ9342/PRO34047" EXACT [UniProtKB:Q6UXN9] synonym: "WDR82A" EXACT [UniProtKB:Q6UXN9] xref: EMBL:AK074290 xref: EMBL:AY358264 xref: HGNC:HGNC:28826 xref: UniGene:Hs.194110 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005688 ! WDR82_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005929 name: WEE1_human def: "Wee1-like protein kinase gene" [UniProtKB:P30291] xref: EMBL:AJ277546 xref: EMBL:U10564 xref: EMBL:X62048 xref: HGNC:HGNC:12761 xref: UniGene:Hs.249441 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001575 ! WEE1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005931 name: WNK4_human def: "Serine/threonine-protein kinase WNK4 gene" [UniProtKB:Q96J92] synonym: "PRKWNK4" EXACT [UniProtKB:Q96J92] xref: EMBL:AF390018 xref: EMBL:AJ309861 xref: EMBL:AJ316534 xref: EMBL:AK096003 xref: EMBL:AK096052 xref: HGNC:HGNC:14544 xref: UniGene:Hs.105448 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005934 ! WNK4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005932 name: WNT16_human def: "Protein Wnt-16 precursor gene" [UniProtKB:Q9UBV4] xref: EMBL:AC006364 xref: EMBL:AF152584 xref: EMBL:AF169963 xref: EMBL:BC104919 xref: EMBL:BC104945 xref: HGNC:HGNC:16267 xref: UniGene:Hs.272375 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006047 ! WNT16_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005933 name: WRN_human def: "Werner syndrome ATP-dependent helicase gene" [UniProtKB:Q14191] synonym: "RECQ3" EXACT [UniProtKB:Q14191] synonym: "RECQL2" EXACT [UniProtKB:Q14191] xref: EMBL:AF091214 xref: EMBL:AF181896 xref: EMBL:AF181897 xref: EMBL:AY442327 xref: EMBL:L76937 xref: HGNC:HGNC:12791 xref: UniGene:Hs.632050 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005358 ! WRN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005934 name: WT1_human def: "Wilms tumor protein gene" [UniProtKB:P19544] xref: EMBL:AL049692 xref: EMBL:AY245105 xref: EMBL:BC032861 xref: EMBL:M30393 xref: EMBL:M80217 xref: EMBL:M80218 xref: EMBL:M80219 xref: EMBL:M80220 xref: EMBL:M80221 xref: EMBL:M80228 xref: EMBL:M80229 xref: EMBL:M80231 xref: EMBL:M80232 xref: EMBL:S60755 xref: EMBL:S61515 xref: EMBL:S61522 xref: EMBL:S61524 xref: EMBL:S75264 xref: EMBL:X51630 xref: EMBL:X61631 xref: EMBL:X61632 xref: EMBL:X61633 xref: EMBL:X61634 xref: EMBL:X61635 xref: EMBL:X61636 xref: EMBL:X61637 xref: EMBL:X61638 xref: HGNC:HGNC:12796 xref: UniGene:Hs.591980 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001536 ! WT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005935 name: WWC1_human def: "Protein WWC1 gene" [UniProtKB:Q8IX03] synonym: "KIAA0869" EXACT [UniProtKB:Q8IX03] xref: EMBL:AB020676 xref: EMBL:AF506799 xref: EMBL:AF530058 xref: EMBL:AY189820 xref: EMBL:BC004394 xref: EMBL:BC017746 xref: EMBL:BX640827 xref: HGNC:HGNC:29435 xref: UniGene:Hs.484047 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006200 ! WWC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005936 name: WWOX_human def: "WW domain-containing oxidoreductase gene" [UniProtKB:Q9NZC7] synonym: "FOR" EXACT [UniProtKB:Q9NZC7] synonym: "WOX1" EXACT [UniProtKB:Q9NZC7] xref: EMBL:AF211943 xref: EMBL:AF212843 xref: EMBL:AF217490 xref: EMBL:AF217491 xref: EMBL:AF217492 xref: EMBL:AF227526 xref: EMBL:AF227527 xref: EMBL:AF227528 xref: EMBL:AF227529 xref: EMBL:AF325423 xref: EMBL:AF325424 xref: EMBL:AF325425 xref: EMBL:AF325426 xref: EMBL:AF325427 xref: EMBL:AF325428 xref: EMBL:AF325429 xref: EMBL:AF325430 xref: EMBL:AF325431 xref: EMBL:AF325432 xref: EMBL:AF325433 xref: EMBL:AF395123 xref: EMBL:AF395124 xref: EMBL:AY256821 xref: EMBL:BC003184 xref: EMBL:BT007445 xref: HGNC:HGNC:12799 xref: UniGene:Hs.461453 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002181 ! WWOX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005937 name: HBXIP_human def: "Hepatitis B virus X-interacting protein gene" [UniProtKB:O43504] synonym: "XIP" EXACT [UniProtKB:O43504] xref: EMBL:AF029890 xref: EMBL:AL390797 xref: EMBL:AY623819 xref: EMBL:BC062619 xref: EMBL:CR456866 xref: EMBL:CR542130 xref: HGNC:HGNC:17955 xref: UniGene:Hs.439815 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041278 ! HBXIP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005938 name: XPA_human def: "DNA-repair protein complementing XP-A cells gene" [UniProtKB:P23025] synonym: "XPAC" EXACT [UniProtKB:P23025] xref: EMBL:AF503166 xref: EMBL:BC014965 xref: EMBL:BT019518 xref: EMBL:D14533 xref: EMBL:U16815 xref: HGNC:HGNC:12814 xref: UniGene:Hs.654364 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005345 ! XPA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005939 name: XPC_human def: "DNA-repair protein complementing XP-C cells gene" [UniProtKB:Q01831] synonym: "XPCC" EXACT [UniProtKB:Q01831] xref: EMBL:AF261892 xref: EMBL:AF261893 xref: EMBL:AF261894 xref: EMBL:AF261895 xref: EMBL:AF261896 xref: EMBL:AF261897 xref: EMBL:AF261898 xref: EMBL:AF261899 xref: EMBL:AF261900 xref: EMBL:AF261901 xref: EMBL:AK222844 xref: EMBL:AY131066 xref: EMBL:BC016620 xref: EMBL:D21089 xref: EMBL:X65024 xref: HGNC:HGNC:12816 xref: UniGene:Hs.475538 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001714 ! XPC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005940 name: XPO1_human def: "Exportin-1 gene" [UniProtKB:O14980] synonym: "CRM1" EXACT [UniProtKB:O14980] xref: EMBL:AC016727 xref: EMBL:BC032847 xref: EMBL:BX647758 xref: EMBL:CR749840 xref: EMBL:D89729 xref: EMBL:Y08614 xref: HGNC:HGNC:12825 xref: UniGene:Hs.370770 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005867 ! XPO1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005941 name: CSE1L_human def: "Exportin-2 gene" [UniProtKB:P55060] synonym: "CAS" EXACT [UniProtKB:P55060] synonym: "XPO2" EXACT [UniProtKB:P55060] xref: EMBL:AF053640 xref: EMBL:AF053641 xref: EMBL:AF053642 xref: EMBL:AF053644 xref: EMBL:AF053645 xref: EMBL:AF053646 xref: EMBL:AF053647 xref: EMBL:AF053648 xref: EMBL:AF053649 xref: EMBL:AF053650 xref: EMBL:AF053651 xref: EMBL:AL121903 xref: EMBL:AL133174 xref: EMBL:BC108309 xref: EMBL:BC109313 xref: EMBL:BC109314 xref: EMBL:U33286 xref: HGNC:HGNC:2431 xref: UniGene:Hs.90073 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005662 ! XPO2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005942 name: XPO7_human def: "Exportin-7 gene" [UniProtKB:Q9UIA9] synonym: "KIAA0745" EXACT [UniProtKB:Q9UIA9] synonym: "RANBP16" EXACT [UniProtKB:Q9UIA9] xref: EMBL:AB018288 xref: EMBL:AF064729 xref: EMBL:BC014219 xref: EMBL:BC030785 xref: HGNC:HGNC:14108 xref: UniGene:Hs.172685 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005665 ! XPO7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005943 name: XPOT_human def: "Exportin-T gene" [UniProtKB:O43592] xref: EMBL:AC135279 xref: EMBL:AF039022 xref: EMBL:BC000950 xref: EMBL:BC020569 xref: EMBL:Y16414 xref: HGNC:HGNC:12826 xref: UniGene:Hs.85951 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005664 ! XPOT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005944 name: XPNPEP1_human def: "Xaa-Pro aminopeptidase 1 gene" [UniProtKB:Q9NQW7] synonym: "XPNPEPL" EXACT [UniProtKB:Q9NQW7] synonym: "XPNPEPL1" EXACT [UniProtKB:Q9NQW7] xref: EMBL:AF195530 xref: EMBL:AF272981 xref: EMBL:AK223513 xref: EMBL:AL354951 xref: EMBL:AL833411 xref: EMBL:BC005126 xref: EMBL:BC007579 xref: EMBL:BC013417 xref: EMBL:CR456922 xref: EMBL:X95762 xref: HGNC:HGNC:12822 xref: UniGene:Hs.390623 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006347 ! XPP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005945 name: XRCC2_human def: "DNA-repair protein XRCC2 gene" [UniProtKB:O43543] xref: EMBL:AC003109 xref: EMBL:AF035587 xref: EMBL:AF520762 xref: EMBL:BC042137 xref: EMBL:Y08837 xref: EMBL:Y17033 xref: HGNC:HGNC:12829 xref: UniGene:Hs.647093 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001392 ! XRCC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005946 name: XRCC4_human def: "DNA-repair protein XRCC4 gene" [UniProtKB:Q13426] xref: EMBL:AB017445 xref: EMBL:AF055279 xref: EMBL:AF055280 xref: EMBL:AF055281 xref: EMBL:AF055282 xref: EMBL:AF055283 xref: EMBL:AF055284 xref: EMBL:AF055285 xref: EMBL:AY940097 xref: EMBL:BC005259 xref: EMBL:BC016314 xref: EMBL:BT007216 xref: EMBL:U40622 xref: HGNC:HGNC:12831 xref: UniGene:Hs.567359 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005651 ! XRCC4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005947 name: XRN1_human def: "5'-3' exoribonuclease 1 gene" [UniProtKB:Q8IZH2] synonym: "SEP1" EXACT [UniProtKB:Q8IZH2] xref: EMBL:AK096177 xref: EMBL:AL133623 xref: EMBL:AY137776 xref: EMBL:BC039314 xref: EMBL:BC048104 xref: EMBL:BX640905 xref: EMBL:CR627396 xref: EMBL:CR749518 xref: HGNC:HGNC:30654 xref: UniGene:Hs.435103 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001954 ! XRN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005948 name: YBX1_human def: "Nuclease-sensitive element-binding protein 1 gene" [UniProtKB:P67809] synonym: "NSEP1" EXACT [UniProtKB:P67809] synonym: "YB1" EXACT [UniProtKB:P67809] xref: EMBL:BC002411 xref: EMBL:BC010430 xref: EMBL:BC015208 xref: EMBL:BC038384 xref: EMBL:BC065571 xref: EMBL:BC070084 xref: EMBL:BC071708 xref: EMBL:BC090038 xref: EMBL:BC098435 xref: EMBL:BC106045 xref: EMBL:J03827 xref: EMBL:L28809 xref: EMBL:M24070 xref: EMBL:M83234 xref: HGNC:HGNC:8014 xref: UniGene:Hs.473583 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005742 ! YBOX1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005949 name: YES1_human def: "Proto-oncogene tyrosine-protein kinase Yes gene" [UniProtKB:P07947] synonym: "YES" EXACT [UniProtKB:P07947] xref: EMBL:AP001178 xref: EMBL:BC048960 xref: EMBL:CH471113 xref: EMBL:M15990 xref: HGNC:HGNC:12841 xref: UniGene:Hs.194148 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005465 ! YES_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005950 name: YEATS4_human def: "YEATS domain-containing protein 4 gene" [UniProtKB:O95619] synonym: "GAS41" EXACT [UniProtKB:O95619] xref: EMBL:AJ245746 xref: EMBL:AK001413 xref: EMBL:BC000994 xref: EMBL:U61384 xref: HGNC:HGNC:24859 xref: UniGene:Hs.4029 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001451 ! YETS4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005951 name: ZBED1_human def: "Zinc finger BED domain-containing protein 1 gene" [UniProtKB:O96006] synonym: "ALTE" EXACT [UniProtKB:O96006] synonym: "DREF" EXACT [UniProtKB:O96006] synonym: "KIAA0785" EXACT [UniProtKB:O96006] synonym: "TRAMP" EXACT [UniProtKB:O96006] xref: EMBL:AB018328 xref: EMBL:BC015030 xref: EMBL:Y16947 xref: EMBL:Y17156 xref: HGNC:HGNC:447 xref: UniGene:Hs.131452 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005231 ! ZBED1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005952 name: ZBTB17_human def: "Zinc finger and BTB domain-containing protein 17 gene" [UniProtKB:Q13105] synonym: "MIZ1" EXACT [UniProtKB:Q13105] synonym: "ZNF151" EXACT [UniProtKB:Q13105] synonym: "ZNF60" EXACT [UniProtKB:Q13105] xref: EMBL:AL034555 xref: EMBL:BC126163 xref: EMBL:M88369 xref: EMBL:U20647 xref: EMBL:Y09723 xref: HGNC:HGNC:12936 xref: UniGene:Hs.433764 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001741 ! ZBT17_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005953 name: ZC3H11A_human def: "Zinc finger CCCH domain-containing protein 11A gene" [UniProtKB:O75152] synonym: "KIAA0663" EXACT [UniProtKB:O75152] synonym: "ZC3HDC11A" EXACT [UniProtKB:O75152] xref: EMBL:AB014563 xref: EMBL:BC014268 xref: EMBL:BC048271 xref: EMBL:BX648271 xref: EMBL:BX649148 xref: EMBL:CR627439 xref: EMBL:CR627446 xref: HGNC:HGNC:29093 xref: UniGene:Hs.532399 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005252 ! ZC11A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005954 name: ZCCHC10_human def: "Zinc finger CCHC domain-containing protein 10 gene" [UniProtKB:Q8TBK6] xref: EMBL:AK000101 xref: EMBL:BC005211 xref: EMBL:BC022443 xref: HGNC:HGNC:25954 xref: UniGene:Hs.29700 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006253 ! ZCH10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005955 name: CREBZF_human def: "CREB/ATF bZIP transcription factor gene" [UniProtKB:Q9NS37] synonym: "ZF" EXACT [UniProtKB:Q9NS37] xref: EMBL:AF039942 xref: EMBL:BC093796 xref: EMBL:BC093798 xref: EMBL:DQ128105 xref: HGNC:HGNC:24905 xref: UniGene:Hs.535319 xref: UniGene:Hs.705539 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005710 ! ZHANG_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005956 name: ZHX1_human def: "Zinc fingers and homeoboxes protein 1 gene" [UniProtKB:Q9UKY1] xref: EMBL:AF106862 xref: EMBL:AF195766 xref: EMBL:BC040481 xref: HGNC:HGNC:12871 xref: UniGene:Hs.612084 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005395 ! ZHX1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005957 name: ZMIZ2_human def: "Zinc finger MIZ domain-containing protein 2 gene" [UniProtKB:Q8NF64] synonym: "HRIHFB2007" EXACT [UniProtKB:Q8NF64] synonym: "KIAA1886" EXACT [UniProtKB:Q8NF64] synonym: "ZIMP7" EXACT [UniProtKB:Q8NF64] xref: EMBL:AB015330 xref: EMBL:AB067473 xref: EMBL:AC004859 xref: EMBL:AC013436 xref: EMBL:AK090415 xref: EMBL:AL136572 xref: EMBL:AL831933 xref: EMBL:AY426594 xref: EMBL:BC021924 xref: EMBL:BC110435 xref: HGNC:HGNC:22229 xref: UniGene:Hs.600681 xref: UniGene:Hs.77978 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005218 ! ZMIZ2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005958 name: ZNF263_human def: "Zinc finger protein 263 gene" [UniProtKB:O14978] synonym: "FPM315" EXACT [UniProtKB:O14978] synonym: "ZKSCAN12" EXACT [UniProtKB:O14978] xref: EMBL:AC004232 xref: EMBL:BC008805 xref: EMBL:D88827 xref: HGNC:HGNC:13056 xref: UniGene:Hs.611475 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005297 ! ZN263_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005959 name: RCHY1_human def: "RING finger and CHY zinc finger domain-containing protein 1 gene" [UniProtKB:Q96PM5] synonym: "ARNIP" EXACT [UniProtKB:Q96PM5] synonym: "CHIMP" EXACT [UniProtKB:Q96PM5] synonym: "PIRH2" EXACT [UniProtKB:Q96PM5] synonym: "RNF199" EXACT [UniProtKB:Q96PM5] synonym: "ZNF363" EXACT [UniProtKB:Q96PM5] xref: EMBL:AF247041 xref: EMBL:AF255666 xref: EMBL:AF305424 xref: HGNC:HGNC:17479 xref: UniGene:Hs.48297 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005980 ! ZN363_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005960 name: ZNF443_human def: "Zinc finger protein 443 gene" [UniProtKB:Q9Y2A4] xref: EMBL:AB011414 xref: EMBL:BC032753 xref: HGNC:HGNC:20878 xref: UniGene:Hs.631623 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006014 ! ZN443_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005961 name: ZNF451_human def: "Zinc finger protein 451 gene" [UniProtKB:Q9Y4E5] synonym: "COASTER" EXACT [UniProtKB:Q9Y4E5] synonym: "KIAA0576" EXACT [UniProtKB:Q9Y4E5] xref: EMBL:AB011148 xref: EMBL:AL136311 xref: EMBL:AL450489 xref: EMBL:AY055204 xref: EMBL:BC021712 xref: HGNC:HGNC:21091 xref: UniGene:Hs.485628 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005308 ! ZN451_HUMAN relationship: codes_for CCO:B0005597 ! Q5VVE9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005963 name: ZNF567_human def: "Zinc finger protein 567 gene" [UniProtKB:Q8N184] xref: EMBL:BC033849 xref: EMBL:BX640706 xref: HGNC:HGNC:28696 xref: UniGene:Hs.412517 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005263 ! ZN567_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005964 name: ZNF580_human def: "Zinc finger protein 580 gene" [UniProtKB:Q9UK33] xref: EMBL:AF184939 xref: EMBL:AL359054 xref: EMBL:BC017698 xref: HGNC:HGNC:29473 xref: UniGene:Hs.631551 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005228 ! ZN580_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005965 name: ZNF581_human def: "Zinc finger protein 581 gene" [UniProtKB:Q9P0T4] synonym: "HSPC189" EXACT [UniProtKB:Q9P0T4] xref: EMBL:AF151023 xref: EMBL:BC001219 xref: EMBL:BC010097 xref: EMBL:BC071620 xref: EMBL:BC071845 xref: HGNC:HGNC:25017 xref: UniGene:Hs.20768 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005214 ! ZN581_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005966 name: ZNF655_human def: "Zinc finger protein 655 gene" [UniProtKB:Q8N720] synonym: "VIK" EXACT [UniProtKB:Q8N720] xref: EMBL:AY099353 xref: EMBL:BC011816 xref: EMBL:BC024770 xref: EMBL:BC037407 xref: HGNC:HGNC:30899 xref: UniGene:Hs.696221 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005578 ! ZN655_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005967 name: ZNF764_human def: "Zinc finger protein 764 gene" [UniProtKB:Q96H86] xref: EMBL:BC000016 xref: EMBL:BC008821 xref: HGNC:HGNC:28200 xref: UniGene:Hs.132227 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005276 ! ZN764_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005968 name: ZNF24_human def: "Zinc finger protein 24 gene" [UniProtKB:P17028] synonym: "KOX17" EXACT [UniProtKB:P17028] synonym: "ZNF191" EXACT [UniProtKB:P17028] synonym: "ZSCAN3" EXACT [UniProtKB:P17028] xref: EMBL:AC116447 xref: EMBL:AF016052 xref: EMBL:AF038964 xref: EMBL:BC003566 xref: EMBL:BC016801 xref: EMBL:U68536 xref: EMBL:X52348 xref: HGNC:HGNC:13032 xref: UniGene:Hs.591057 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006085 ! ZNF24_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005970 name: ZNHIT1_human def: "Zinc finger HIT domain-containing protein 1 gene" [UniProtKB:O43257] synonym: "CGBP1" EXACT [UniProtKB:O43257] synonym: "ZNFN4A1" EXACT [UniProtKB:O43257] xref: EMBL:AC004876 xref: EMBL:AF093571 xref: EMBL:BC017333 xref: EMBL:U61837 xref: HGNC:HGNC:21688 xref: UniGene:Hs.211079 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005362 ! ZNHI1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005971 name: ZNHIT4_human def: "Zinc finger HIT domain-containing protein 4 gene" [UniProtKB:Q9C086] synonym: "HMGA1L4" EXACT [UniProtKB:Q9C086] synonym: "PAPA1" EXACT [UniProtKB:Q9C086] xref: EMBL:AB054538 xref: EMBL:BC050666 xref: EMBL:BC064425 xref: HGNC:HGNC:13324 xref: UniGene:Hs.410786 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006055 ! ZNHI4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005973 name: ZW10_human def: "Centromere/kinetochore protein zw10 homolog gene" [UniProtKB:O43264] xref: EMBL:U54996 xref: HGNC:HGNC:13194 xref: UniGene:Hs.503886 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001387 ! ZW10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005974 name: ZWINTAS_human def: "Putative ZW10 interactor antisense gene" [UniProtKB:Q99546] synonym: "MPHOSPH5" EXACT [UniProtKB:Q99546] synonym: "MPP5" EXACT [UniProtKB:Q99546] xref: EMBL:X98261 xref: HGNC:HGNC:13196 xref: UniGene:Hs.591363 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002070 ! ZWIA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005975 name: ZWINT_human def: "ZW10 interactor gene" [UniProtKB:O95229] xref: EMBL:AF067656 xref: EMBL:BC000411 xref: EMBL:BC020979 xref: EMBL:BC110399 xref: HGNC:HGNC:13195 xref: UniGene:Hs.591363 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001449 ! ZWINT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005976 name: ZYX_human def: "Zyxin gene" [UniProtKB:Q15942] xref: EMBL:AC092214 xref: EMBL:BC008743 xref: EMBL:BC009360 xref: EMBL:BC010031 xref: EMBL:CR457431 xref: EMBL:X94991 xref: EMBL:X95735 xref: HGNC:HGNC:13200 xref: UniGene:Hs.490415 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005704 ! ZYX_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005977 name: ZZEF1_human def: "Zinc finger ZZ-type and EF-hand domain-containing protein 1 gene" [UniProtKB:O43149] synonym: "KIAA0399" EXACT [UniProtKB:O43149] xref: EMBL:AB007859 xref: EMBL:AK001683 xref: EMBL:AK127482 xref: EMBL:AK128386 xref: EMBL:BC067099 xref: HGNC:HGNC:29027 xref: UniGene:Hs.277624 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001380 ! ZZEF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005978 name: LOC392884_human def: "Similar to cell division cycle 10 homolog gene" [UniProtKB:A4D1Y2] synonym: "tcag7.1317" EXACT [UniProtKB:A4D1Y2] xref: EMBL:CH236951 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001318 ! A4D1Y2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005983 name: EED_human def: "Embryonic ectoderm development protein gene" [UniProtKB:O75530] xref: EMBL:AF070418 xref: HGNC:HGNC:3188 xref: UniGene:Hs.503510 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005659 ! O75530_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005984 name: PPP1R15A_human def: "Protein phosphatase 1 regulatory subunit 15A gene" [UniProtKB:O75807] synonym: "GADD34" EXACT [UniProtKB:O75807] xref: EMBL:AK001361 xref: EMBL:BC003067 xref: EMBL:CH471177 xref: EMBL:CR457259 xref: EMBL:U83981 xref: HGNC:HGNC:14375 xref: UniGene:Hs.631593 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001436 ! PR15A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005986 name: C20orf69_human def: "Putative uncharacterized protein C20orf69 gene" [UniProtKB:Q0VF47] xref: EMBL:AL137028 xref: EMBL:BC118988 xref: EMBL:BC122537 xref: HGNC:HGNC:16202 xref: UniGene:Hs.473317 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001729 ! CT069_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005990 name: G1 phase-specific gene_human def: "G1 phase-specific gene" [UniProtKB:Q16164] xref: EMBL:S70622 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001815 ! Q16164_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005991 name: TP53AP1_human def: "Tumor protein p53-activated protein 1 gene" [UniProtKB:Q52MB0] xref: EMBL:BC061927 xref: HGNC:HGNC:17026 xref: UniGene:Hs.274329 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006165 ! Q52MB0_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005992 name: PTD004_human def: "Putative uncharacterized protein PTD004 gene" [UniProtKB:Q53SQ6] xref: EMBL:AC016737 xref: HGNC:HGNC:28833 xref: UniGene:Hs.157351 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006293 ! Q53SQ6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005997 name: RP11-787I22.2-003_human def: "p53 regulated PA26 nuclear protein gene" [UniProtKB:Q5T317] xref: EMBL:AL390208 xref: HGNC:HGNC:21595 xref: UniGene:Hs.591336 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001872 ! Q5T317_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0005999 name: BMI1_human def: "BMI1 polycomb ring finger oncogene gene" [UniProtKB:Q5T8Z1] synonym: "RP11-573G6.1-004" EXACT [UniProtKB:Q5T8Z1] xref: EMBL:AL158211 xref: HGNC:HGNC:1066 xref: UniGene:Hs.496613 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006124 ! Q5T8Z1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006001 name: PDE4DIP_human def: "Phosphodiesterase 4D interacting protein gene" [UniProtKB:Q5TB27] synonym: "RP4-791M13.2-009" EXACT [UniProtKB:Q5TB27] xref: EMBL:AL138791 xref: HGNC:HGNC:15580 xref: UniGene:Hs.584841 xref: UniGene:Hs.613082 xref: UniGene:Hs.654651 xref: UniGene:Hs.657490 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005975 ! Q5TB27_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006002 name: RP3-330M21.2_human def: "Novel protein gene" [UniProtKB:Q5TCY3] synonym: "hCG_1818381" EXACT [UniProtKB:Q5TCY3] synonym: "PARC" EXACT [UniProtKB:Q5TCY3] synonym: "RP3-330M21.2-001" EXACT [UniProtKB:Q5TCY3] xref: EMBL:AL133375 xref: EMBL:CH471081 xref: UniGene:Hs.485434 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001888 ! Q5TCY3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006003 name: RP11-291L22.2-003_human def: "Septin gene" [UniProtKB:Q5W161] xref: EMBL:AL133216 xref: UniGene:Hs.406568 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001901 ! Q5W161_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006004 name: KLHLX_human def: "KLEIP gene" [UniProtKB:Q5ZF45] xref: EMBL:AJ844466 xref: HGNC:HGNC:25056 xref: UniGene:Hs.495035 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006170 ! Q5ZF45_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006005 name: C9orf78_human def: "Hepatocellular carcinoma-associated antigen 59 gene" [UniProtKB:Q6GVN4] xref: EMBL:AY632862 xref: HGNC:HGNC:24932 xref: UniGene:Hs.278429 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006238 ! Q6GVN4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006007 name: TM4SF6_human def: "TM4SF6 protein gene" [UniProtKB:Q6IAN9] synonym: "hCG_19468" EXACT [UniProtKB:Q6IAN9] synonym: "TSPAN6" EXACT [UniProtKB:Q6IAN9] xref: EMBL:CH471115 xref: EMBL:CR457115 xref: HGNC:HGNC:11858 xref: UniGene:Hs.43233 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006247 ! Q6IAN9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006008 name: ARHH_human def: "ARHH protein gene" [UniProtKB:Q6ICP4] synonym: "hCG_37394" EXACT [UniProtKB:Q6ICP4] synonym: "RHOH" EXACT [UniProtKB:Q6ICP4] xref: EMBL:CH471069 xref: EMBL:CR450349 xref: HGNC:HGNC:686 xref: UniGene:Hs.654594 xref: UniGene:Hs.694951 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006171 ! Q6ICP4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006009 name: LOC441601_human def: "Septin 7 pseudogene gene" [UniProtKB:Q6NVV2] xref: EMBL:BC067889 xref: UniGene:Hs.144683 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001910 ! Q6NVV2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006012 name: HOM-TES-103_human def: "HOM-TES-103 protein gene" [UniProtKB:Q6P593] xref: EMBL:BC063004 xref: UniGene:Hs.15243 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005963 ! Q6P593_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006013 name: RIPK3_human def: "Receptor-interacting serine-threonine kinase 3 gene" [UniProtKB:Q6P5Y1] synonym: "hCG_40180" EXACT [UniProtKB:Q6P5Y1] xref: EMBL:AY453693 xref: EMBL:BC062584 xref: EMBL:CH471078 xref: HGNC:HGNC:10021 xref: UniGene:Hs.268551 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005530 ! Q6P5Y1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006016 name: RFXDC1_human def: "Regulatory factor X domain-containing protein 1 gene" [UniProtKB:Q8HWS3] xref: EMBL:AL355272 xref: EMBL:BC039248 xref: EMBL:CH471051 xref: HGNC:HGNC:21478 xref: UniGene:Hs.352276 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0031197 ! RFXD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006017 name: IL16_human def: "IL16 protein gene" [UniProtKB:Q8IUU6] xref: EMBL:BC040272 xref: HGNC:HGNC:5980 xref: UniGene:Hs.459095 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005242 ! Q8IUU6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006018 name: ZNF646_human def: "Zinc finger protein 646 gene" [UniProtKB:Q8IVD8] synonym: "hCG_18384" EXACT [UniProtKB:Q8IVD8] xref: EMBL:BC035589 xref: EMBL:CH471192 xref: HGNC:HGNC:29004 xref: UniGene:Hs.119273 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005230 ! Q8IVD8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006019 name: ATXN7L3_human def: "Ataxin-7-like protein 3 gene" [UniProtKB:Q8IY68] xref: EMBL:BC037418 xref: HGNC:HGNC:25416 xref: UniGene:Hs.512651 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005946 ! Q8IY68_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006020 name: SEPT12_human def: "Septin-12 gene" [UniProtKB:Q8IYM1] xref: EMBL:AK058139 xref: EMBL:BC024017 xref: EMBL:BC035619 xref: EMBL:CH471112 xref: EMBL:DQ456996 xref: EMBL:DQ517531 xref: EMBL:EF620906 xref: HGNC:HGNC:26348 xref: UniGene:Hs.126780 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026253 ! SEP12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006021 name: MYO15B_human def: "MYO15B protein gene" [UniProtKB:Q8N374] xref: EMBL:BC027875 xref: HGNC:HGNC:14083 xref: UniGene:Hs.390817 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005196 ! Q8N374_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006022 name: TRBV21-1_human def: "TRBV21-1 protein gene" [UniProtKB:Q8N3Z8] xref: EMBL:BC036926 xref: HGNC:HGNC:12198 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006251 ! Q8N3Z8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006023 name: ZWILCH_human def: "Protein zwilch homolog gene" [UniProtKB:Q9H900] xref: EMBL:AK000898 xref: EMBL:AK023175 xref: EMBL:AK027468 xref: EMBL:BC036900 xref: EMBL:BC090041 xref: EMBL:BX640701 xref: EMBL:CH471082 xref: HGNC:HGNC:25468 xref: UniGene:Hs.21331 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0032821 ! ZWILC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006024 name: IKZF3_human def: "IKAROS family zinc finger 3 gene" [UniProtKB:Q8N574] synonym: "hCG_30014" EXACT [UniProtKB:Q8N574] synonym: "ZNFN1A3" EXACT [UniProtKB:Q8N574] xref: EMBL:BC032707 xref: EMBL:CH471152 xref: HGNC:HGNC:13178 xref: UniGene:Hs.444388 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005238 ! Q8N574_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006025 name: JMY_human def: "Junction-mediating and -regulatory protein gene" [UniProtKB:Q8N9B5] xref: EMBL:AC016559 xref: EMBL:AC020898 xref: EMBL:AK095189 xref: EMBL:BC130624 xref: EMBL:CH471084 xref: UniGene:Hs.482605 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0040022 ! JMY_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006026 name: DKFZp586M1819_human def: "Putative uncharacterized protein DKFZp586M1819 gene" [UniProtKB:Q8NDD3] xref: EMBL:AL834255 xref: HGNC:HGNC:20880 xref: UniGene:Hs.355753 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005953 ! Q8NDD3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006027 name: OK/SW-cl.16_human def: "OK/SW-CL.16 gene" [UniProtKB:Q8NI70] xref: EMBL:AB064665 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005408 ! Q8NI70_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006028 name: RHEBL1_human def: "GTPase RhebL1 precursor gene" [UniProtKB:Q8TAI7] xref: EMBL:AK098663 xref: EMBL:AY327412 xref: EMBL:AY509932 xref: EMBL:BC027482 xref: EMBL:CH471111 xref: HGNC:HGNC:21166 xref: UniGene:Hs.159013 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0040684 ! REBL1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006029 name: AFF4_human def: "AFF4 protein gene" [UniProtKB:Q8TAX5] xref: EMBL:BC025700 xref: HGNC:HGNC:17869 xref: UniGene:Hs.519313 xref: UniGene:Hs.664840 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005236 ! Q8TAX5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006030 name: PAK7_human def: "p21(CDKN1A)-activated kinase 7 gene" [UniProtKB:Q8TB93] xref: EMBL:BC024179 xref: HGNC:HGNC:15916 xref: UniGene:Hs.32539 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005193 ! Q8TB93_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006031 name: LRFN1_human def: "LRFN1 protein gene" [UniProtKB:Q8TBS9] xref: EMBL:BC025310 xref: HGNC:HGNC:29290 xref: UniGene:Hs.97860 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006297 ! Q8TBS9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006032 name: ANKRD24_human def: "Ankyrin repeat domain-containing protein 24 gene" [UniProtKB:Q8TF21] synonym: "KIAA1981" EXACT [UniProtKB:Q8TF21] xref: EMBL:AB075861 xref: EMBL:AC005578 xref: EMBL:AC006930 xref: HGNC:HGNC:29424 xref: UniGene:Hs.197872 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0040685 ! ANR24_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006034 name: ZNF446_human def: "ZNF446 protein gene" [UniProtKB:Q96AF5] xref: EMBL:BC017206 xref: HGNC:HGNC:21036 xref: UniGene:Hs.697107 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005269 ! Q96AF5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006035 name: ATF4_human def: "Activating transcription factor 4 gene" [UniProtKB:Q96AQ3] synonym: "hCG_41721" EXACT [UniProtKB:Q96AQ3] xref: EMBL:BC016855 xref: EMBL:BC022088 xref: EMBL:BC044895 xref: EMBL:BC073754 xref: EMBL:CH471095 xref: EMBL:CR456384 xref: HGNC:HGNC:786 xref: UniGene:Hs.496487 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005172 ! Q96AQ3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006037 name: CUTC_human def: "CUTC protein gene" [UniProtKB:Q96BX3] xref: EMBL:BC015059 xref: HGNC:HGNC:24271 xref: UniGene:Hs.16606 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005203 ! Q96BX3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006038 name: POM121_human def: "POM121 membrane glycoprotein gene" [UniProtKB:Q96HA1] synonym: "RASSF2" EXACT [UniProtKB:Q96HA1] xref: EMBL:AC005488 xref: EMBL:BC008794 xref: HGNC:HGNC:19702 xref: UniGene:Hs.655217 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005245 ! Q96HA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006039 name: JUB_human def: "Protein ajuba gene" [UniProtKB:Q96IF1] xref: EMBL:AY169959 xref: EMBL:BC007580 xref: EMBL:BC034968 xref: EMBL:CH471078 xref: HGNC:HGNC:20250 xref: UniGene:Hs.655832 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026254 ! JUB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006040 name: hCG_2002594_human def: "Septin gene" [UniProtKB:Q96MY5] xref: EMBL:AK056273 xref: EMBL:CH471176 xref: HGNC:HGNC:9164 xref: UniGene:Hs.283743 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002050 ! Q96MY5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006042 name: CE5B3 alpha_human def: "Bradeion alpha gene" [UniProtKB:Q96Q97] xref: EMBL:AB002110 xref: HGNC:HGNC:9165 xref: UniGene:Hs.287518 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002057 ! Q96Q97_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006044 name: X-1_human def: "X-1 protein gene" [UniProtKB:Q99539] xref: EMBL:X98266 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002068 ! Q99539_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006046 name: TUBGCP4_human def: "TUBGCP4 protein gene" [UniProtKB:Q9BVR6] xref: EMBL:BC000966 xref: UniGene:Hs.654843 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005189 ! Q9BVR6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006047 name: PCBP4_human def: "RNA binding protein MCG10 gene" [UniProtKB:Q9GZT1] synonym: "hCG_42594" EXACT [UniProtKB:Q9GZT1] xref: EMBL:AF257770 xref: EMBL:AF257772 xref: EMBL:CH471055 xref: HGNC:HGNC:8652 xref: UniGene:Hs.20930 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002121 ! Q9GZT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006048 name: PNUTL2_human def: "ARTS protein gene" [UniProtKB:Q9H315] synonym: "hCG_30696" EXACT [UniProtKB:Q9H315] synonym: "SEPT4" EXACT [UniProtKB:Q9H315] xref: EMBL:AF176379 xref: EMBL:CH471109 xref: HGNC:HGNC:9165 xref: UniGene:Hs.287518 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002132 ! Q9H315_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006049 name: KIAA1549_human def: "KIAA1549 protein gene" [UniProtKB:Q9HCM3] xref: EMBL:AB046769 xref: UniGene:Hs.605380 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005548 ! Q9HCM3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006052 name: RPRM_human def: "Protein reprimo gene" [UniProtKB:Q9NS64] xref: EMBL:AB043585 xref: EMBL:AC012501 xref: EMBL:BC002908 xref: EMBL:CH471058 xref: HGNC:HGNC:24201 xref: UniGene:Hs.100890 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026256 ! RPRM_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006053 name: KIF15_human def: "Kinesin-like protein KIF15 gene" [UniProtKB:Q9NS87] synonym: "KLP2" EXACT [UniProtKB:Q9NS87] synonym: "KNSL7" EXACT [UniProtKB:Q9NS87] xref: EMBL:AB035898 xref: EMBL:AF308294 xref: EMBL:AK027816 xref: EMBL:AL832908 xref: EMBL:BC117174 xref: HGNC:HGNC:17273 xref: UniGene:Hs.658939 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002165 ! KIF15_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006054 name: DKFZp547B243_human def: "Septin gene" [UniProtKB:Q9NSH2] xref: EMBL:AL353938 xref: HGNC:HGNC:14349 xref: UniGene:Hs.469615 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0002166 ! Q9NSH2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006055 name: IQWD1_human def: "PC326 protein gene" [UniProtKB:Q9P0U0] synonym: "PC326" EXACT [UniProtKB:Q9P0U0] xref: EMBL:AF150734 xref: HGNC:HGNC:30002 xref: UniGene:Hs.435741 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006353 ! Q9P0U0_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006057 name: KIAA0387_human def: "KIAA0387 protein gene" [UniProtKB:Q9Y4F8] xref: EMBL:AB002385 xref: HGNC:HGNC:9677 xref: UniGene:Hs.490789 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005544 ! Q9Y4F8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006344 name: AGRN_human def: "Agrin precursor gene" [UniProtKB:O00468] synonym: "AGRIN" EXACT [UniProtKB:O00468] xref: EMBL:AB191264 xref: EMBL:AF016903 xref: EMBL:AL645608 xref: EMBL:BC004220 xref: EMBL:BC007649 xref: EMBL:BC034009 xref: EMBL:BC063620 xref: EMBL:U84406 xref: HGNC:HGNC:329 xref: UniGene:Hs.273330 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005949 ! AGRIN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006346 name: CALCOCO2_human def: "Calcium-binding and coiled-coil domain-containing protein 2 gene" [UniProtKB:Q13137] synonym: "NDP52" EXACT [UniProtKB:Q13137] xref: EMBL:AK222666 xref: EMBL:AK223227 xref: EMBL:BC004130 xref: EMBL:BC015893 xref: EMBL:CH471109 xref: EMBL:CR456763 xref: EMBL:U22897 xref: HGNC:HGNC:29912 xref: UniGene:Hs.514920 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026268 ! CACO2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006348 name: HSD17B14_human def: "17-beta-hydroxysteroid dehydrogenase 14 gene" [UniProtKB:Q9BPX1] synonym: "DHRS10" EXACT [UniProtKB:Q9BPX1] synonym: "SDR3" EXACT [UniProtKB:Q9BPX1] synonym: "UNQ502/PRO474" EXACT [UniProtKB:Q9BPX1] xref: EMBL:AF126781 xref: EMBL:AY358430 xref: EMBL:BC006283 xref: EMBL:BC006294 xref: HGNC:HGNC:23238 xref: UniGene:Hs.18788 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026267 ! DHB14_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006349 name: EIF3B_human def: "Eukaryotic translation initiation factor 3 subunit B gene" [UniProtKB:P55884] synonym: "EIF3S9" EXACT [UniProtKB:P55884] xref: EMBL:BC001173 xref: EMBL:BC110865 xref: EMBL:U62583 xref: EMBL:U78525 xref: HGNC:HGNC:3280 xref: UniGene:Hs.371001 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026275 ! EIF3B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006350 name: EIF3C_human def: "Eukaryotic translation initiation factor 3 subunit C gene" [UniProtKB:Q99613] synonym: "EIF3S8" EXACT [UniProtKB:Q99613] xref: EMBL:AC002544 xref: EMBL:AK000739 xref: EMBL:BC001571 xref: EMBL:BC071705 xref: EMBL:U46025 xref: EMBL:U91326 xref: HGNC:HGNC:3279 xref: UniGene:Hs.567374 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026271 ! EIF3C_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006351 name: EIF3D_human def: "Eukaryotic translation initiation factor 3 subunit D gene" [UniProtKB:O15371] synonym: "EIF3S7" EXACT [UniProtKB:O15371] xref: EMBL:AL022313 xref: EMBL:BC000328 xref: EMBL:BC000469 xref: EMBL:BC014912 xref: EMBL:BC080515 xref: EMBL:BC093100 xref: EMBL:BC093686 xref: EMBL:BC101477 xref: EMBL:BT007381 xref: EMBL:CR456489 xref: EMBL:U54558 xref: HGNC:HGNC:3278 xref: UniGene:Hs.55682 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026270 ! EIF3D_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006352 name: EIF3E_human def: "Eukaryotic translation initiation factor 3 subunit E gene" [UniProtKB:P60228] synonym: "EIF3S6" EXACT [UniProtKB:P60228] synonym: "INT6" EXACT [UniProtKB:P60228] xref: EMBL:BC000734 xref: EMBL:BC008419 xref: EMBL:BC016706 xref: EMBL:BC021679 xref: EMBL:U54562 xref: EMBL:U62962 xref: EMBL:U85947 xref: EMBL:U94162 xref: EMBL:U94163 xref: EMBL:U94164 xref: EMBL:U94165 xref: EMBL:U94166 xref: EMBL:U94167 xref: EMBL:U94168 xref: EMBL:U94169 xref: EMBL:U94170 xref: EMBL:U94171 xref: EMBL:U94172 xref: EMBL:U94173 xref: EMBL:U94174 xref: EMBL:U94175 xref: HGNC:HGNC:3277 xref: UniGene:Hs.405590 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026272 ! EIF3E_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006354 name: EIF3G_human def: "Eukaryotic translation initiation factor 3 subunit G gene" [UniProtKB:O75821] synonym: "EIF3S4" EXACT [UniProtKB:O75821] xref: EMBL:AF020833 xref: EMBL:AF092453 xref: EMBL:AF094850 xref: EMBL:BC000733 xref: EMBL:BC008469 xref: EMBL:BT006889 xref: EMBL:U96074 xref: HGNC:HGNC:3274 xref: UniGene:Hs.529059 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026269 ! EIF3G_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006355 name: EIF3I_human def: "Eukaryotic translation initiation factor 3 subunit I gene" [UniProtKB:Q13347] synonym: "EIF3S2" EXACT [UniProtKB:Q13347] synonym: "TRIP1" EXACT [UniProtKB:Q13347] xref: EMBL:BC000413 xref: EMBL:BC003140 xref: EMBL:U36764 xref: EMBL:U39067 xref: HGNC:HGNC:3272 xref: UniGene:Hs.530096 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026273 ! EIF3I_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006356 name: EIF3J_human def: "Eukaryotic translation initiation factor 3 subunit J gene" [UniProtKB:O75822] synonym: "EIF3S1" EXACT [UniProtKB:O75822] synonym: "PRO0391" EXACT [UniProtKB:O75822] xref: EMBL:AF090923 xref: EMBL:AK023388 xref: EMBL:BC002719 xref: EMBL:U97670 xref: HGNC:HGNC:3270 xref: UniGene:Hs.404056 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026278 ! EIF3J_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006357 name: EIF3K_human def: "Eukaryotic translation initiation factor 3 subunit K gene" [UniProtKB:Q9UBQ5] synonym: "ARG134" EXACT [UniProtKB:Q9UBQ5] synonym: "EIF3S12" EXACT [UniProtKB:Q9UBQ5] synonym: "HSPC029" EXACT [UniProtKB:Q9UBQ5] synonym: "MSTP001" EXACT [UniProtKB:Q9UBQ5] synonym: "PTD001" EXACT [UniProtKB:Q9UBQ5] xref: EMBL:AB019392 xref: EMBL:AF077051 xref: EMBL:AF085358 xref: EMBL:AF109355 xref: EMBL:AF315506 xref: EMBL:AY245432 xref: EMBL:BC001031 xref: EMBL:BC007335 xref: EMBL:BC007559 xref: HGNC:HGNC:24656 xref: UniGene:Hs.314359 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026274 ! EIF3K_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006358 name: ERCC2_human def: "TFIIH basal transcription factor complex helicase subunit gene" [UniProtKB:P18074] synonym: "XPD" EXACT [UniProtKB:P18074] synonym: "XPDC" EXACT [UniProtKB:P18074] xref: EMBL:AY092780 xref: EMBL:BC108255 xref: EMBL:L47234 xref: EMBL:X52221 xref: EMBL:X52222 xref: HGNC:HGNC:3434 xref: UniGene:Hs.487294 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026248 ! ERCC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006359 name: HNF1A_human def: "Hepatocyte nuclear factor 1-alpha gene" [UniProtKB:P20823] synonym: "TCF1" EXACT [UniProtKB:P20823] xref: EMBL:BC104908 xref: EMBL:BC104910 xref: EMBL:M57732 xref: EMBL:U72612 xref: EMBL:U72613 xref: EMBL:U72614 xref: EMBL:U72615 xref: EMBL:U72616 xref: EMBL:U72617 xref: EMBL:U72618 xref: EMBL:X71346 xref: HGNC:HGNC:11621 xref: UniGene:Hs.654455 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006008 ! HNF1A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006360 name: HNRNPC_human def: "Heterogeneous nuclear ribonucleoproteins C1/C2 gene" [UniProtKB:P07910] synonym: "HNRPC" EXACT [UniProtKB:P07910] xref: EMBL:AB209527 xref: EMBL:AK223517 xref: EMBL:BC003394 xref: EMBL:BC007052 xref: EMBL:BC008364 xref: EMBL:BC008423 xref: EMBL:BC066932 xref: EMBL:BC089438 xref: EMBL:BC103758 xref: EMBL:BC108658 xref: EMBL:BX161480 xref: EMBL:BX247961 xref: EMBL:BX247992 xref: EMBL:M16342 xref: EMBL:M29063 xref: HGNC:HGNC:5035 xref: UniGene:Hs.449114 xref: UniGene:Hs.508848 xref: UniGene:Hs.701780 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005239 ! HNRPC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006361 name: HNRNPL_human def: "Heterogeneous nuclear ribonucleoprotein L gene" [UniProtKB:P14866] synonym: "HNRPL" EXACT [UniProtKB:P14866] synonym: "P/OKcl.14" EXACT [UniProtKB:P14866] xref: EMBL:AB044547 xref: EMBL:X16135 xref: HGNC:HGNC:5045 xref: UniGene:Hs.654559 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006275 ! HNRPL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006362 name: EIF3EIP_human def: "Eukaryotic translation initiation factor 3 subunit E-interacting protein gene" [UniProtKB:Q9Y262] synonym: "EIF3S6IP" EXACT [UniProtKB:Q9Y262] synonym: "HSPC021" EXACT [UniProtKB:Q9Y262] synonym: "HSPC025" EXACT [UniProtKB:Q9Y262] synonym: "MSTP005" EXACT [UniProtKB:Q9Y262] xref: EMBL:AF077207 xref: EMBL:AF083243 xref: EMBL:AF109359 xref: EMBL:AK222496 xref: EMBL:AK222529 xref: EMBL:AL022311 xref: EMBL:BC001101 xref: EMBL:BC007510 xref: EMBL:BC029265 xref: EMBL:CR456436 xref: EMBL:Z97630 xref: HGNC:HGNC:18138 xref: UniGene:Hs.446852 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026279 ! IF3EI_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006363 name: KLHDC3_human def: "Kelch domain-containing protein 3 gene" [UniProtKB:Q9BQ90] synonym: "PEAS" EXACT [UniProtKB:Q9BQ90] xref: EMBL:AB055925 xref: EMBL:AL136304 xref: EMBL:BC000295 xref: EMBL:BC001789 xref: EMBL:BC001793 xref: EMBL:BC007296 xref: EMBL:BC021546 xref: HGNC:HGNC:20704 xref: UniGene:Hs.412468 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026255 ! KLDC3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006364 name: NOXIN_human def: "Nitric oxide-inducible gene" [UniProtKB:Q8IXT1] synonym: "C11orf82" EXACT [UniProtKB:Q8IXT1] xref: EMBL:AK023998 xref: EMBL:AK058145 xref: EMBL:AP001646 xref: EMBL:BC039268 xref: HGNC:HGNC:26351 xref: UniGene:Hs.165607 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026252 ! NOXIN_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006365 name: PDS5B_human def: "Sister chromatid cohesion protein PDS5 homolog B gene" [UniProtKB:Q9NTI5] synonym: "APRIN" EXACT [UniProtKB:Q9NTI5] synonym: "AS3" EXACT [UniProtKB:Q9NTI5] synonym: "KIAA0979" EXACT [UniProtKB:Q9NTI5] xref: EMBL:AB023196 xref: EMBL:AK026889 xref: EMBL:AL137201 xref: EMBL:AL138820 xref: EMBL:BC039256 xref: EMBL:BC070274 xref: EMBL:U95825 xref: EMBL:Z75889 xref: HGNC:HGNC:20418 xref: UniGene:Hs.699308 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026257 ! PDS5B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006367 name: PRIM2_human def: "DNA primase large subunit gene" [UniProtKB:P49643] synonym: "PRIM2A" EXACT [UniProtKB:P49643] xref: EMBL:AL121975 xref: EMBL:AL162579 xref: EMBL:BC017833 xref: EMBL:BC064931 xref: EMBL:X74331 xref: HGNC:HGNC:9370 xref: UniGene:Hs.654580 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005508 ! PRI2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006368 name: HNRNPA1_human def: "Heterogeneous nuclear ribonucleoprotein A1 gene" [UniProtKB:P09651] synonym: "HNRPA1" EXACT [UniProtKB:P09651] xref: EMBL:BC002355 xref: EMBL:BC009600 xref: EMBL:BC012158 xref: EMBL:BC033714 xref: EMBL:BC052296 xref: EMBL:BC070315 xref: EMBL:BC074502 xref: EMBL:X04347 xref: EMBL:X06747 xref: EMBL:X12671 xref: EMBL:X79536 xref: HGNC:HGNC:5031 xref: UniGene:Hs.655424 xref: UniGene:Hs.699190 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005774 ! ROA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006369 name: HNRNPA2B1_human def: "Heterogeneous nuclear ribonucleoproteins A2/B1 gene" [UniProtKB:P22626] synonym: "HNRPA2B1" EXACT [UniProtKB:P22626] xref: EMBL:D28877 xref: EMBL:M29064 xref: EMBL:M29065 xref: EMBL:U09120 xref: EMBL:U09121 xref: EMBL:U09122 xref: EMBL:U09123 xref: HGNC:HGNC:5033 xref: UniGene:Hs.487774 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005725 ! ROA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006370 name: SPC24_human def: "Kinetochore protein Spc24 gene" [UniProtKB:Q8NBT2] synonym: "SPBC24" EXACT [UniProtKB:Q8NBT2] xref: EMBL:AK075287 xref: EMBL:AY456387 xref: EMBL:BC105037 xref: EMBL:BC105039 xref: HGNC:HGNC:26913 xref: UniGene:Hs.381225 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001973 ! SPC24_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006371 name: FARSB_human def: "Phenylalanyl-tRNA synthetase beta chain gene" [UniProtKB:Q9NSD9] synonym: "FARSLB" EXACT [UniProtKB:Q9NSD9] synonym: "FRSB" EXACT [UniProtKB:Q9NSD9] synonym: "HSPC173" EXACT [UniProtKB:Q9NSD9] xref: EMBL:AF042346 xref: EMBL:AF161521 xref: EMBL:BC017783 xref: EMBL:D84430 xref: HGNC:HGNC:17800 xref: UniGene:Hs.471452 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005753 ! SYFB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006374 name: ZMYND11_human def: "Zinc finger MYND domain-containing protein 11 gene" [UniProtKB:Q15326] synonym: "BS69" EXACT [UniProtKB:Q15326] xref: EMBL:AL589988 xref: EMBL:AL603831 xref: EMBL:X86098 xref: HGNC:HGNC:16966 xref: UniGene:Hs.292265 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026249 ! ZMY11_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006375 name: NEDD5_human def: "Septin gene" [UniProtKB:Q53QU3] xref: EMBL:AC104841 xref: HGNC:HGNC:7729 xref: UniGene:Hs.335057 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0023650 ! Q53QU3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006376 name: DKFZp586I031_human def: "Putative uncharacterized protein DKFZp586I031 gene" [UniProtKB:Q5JXL7] xref: EMBL:AL050392 xref: HGNC:HGNC:1717 xref: UniGene:Hs.191346 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0026250 ! Q5JXL7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006401 name: COPS3_human def: "COP9 signalosome complex subunit 3 gene" [UniProtKB:Q9UNS2] synonym: "CSN3" EXACT [UniProtKB:Q9UNS2] xref: EMBL:AF031647 xref: EMBL:AF098109 xref: EMBL:BC001891 xref: HGNC:HGNC:2239 xref: UniGene:Hs.6076 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0030750 ! CSN3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006402 name: VAMP3_human def: "Vesicle-associated membrane protein 3 gene" [UniProtKB:Q15836] synonym: "SYB3" EXACT [UniProtKB:Q15836] xref: EMBL:BC003570 xref: EMBL:BC007050 xref: EMBL:BT007327 xref: EMBL:U64520 xref: EMBL:Z98884 xref: HGNC:HGNC:12644 xref: UniGene:Hs.66708 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0030751 ! VAMP3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006414 name: MOBKL3_human def: "Mps one binder kinase activator-like 3 gene" [UniProtKB:Q9Y3A3] synonym: "CGI-95" EXACT [UniProtKB:Q9Y3A3] synonym: "MOB3" EXACT [UniProtKB:Q9Y3A3] synonym: "PREI3" EXACT [UniProtKB:Q9Y3A3] xref: EMBL:AB015441 xref: EMBL:AF093825 xref: EMBL:AF151853 xref: EMBL:AF250319 xref: EMBL:AJ580638 xref: EMBL:AK027043 xref: EMBL:AL080070 xref: EMBL:BC005237 xref: EMBL:CR457371 xref: HGNC:HGNC:17261 xref: UniGene:Hs.645458 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0031198 ! MOBL3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006415 name: NDC80_human def: "Kinetochore protein NDC80 homolog gene" [UniProtKB:O14777] synonym: "HEC" EXACT [UniProtKB:O14777] synonym: "HEC1" EXACT [UniProtKB:O14777] synonym: "KNTC2" EXACT [UniProtKB:O14777] xref: EMBL:AF017790 xref: EMBL:BC010171 xref: HGNC:HGNC:16909 xref: UniGene:Hs.414407 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001360 ! NDC80_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006416 name: UBA3_human def: "NEDD8-activating enzyme E1 catalytic subunit gene" [UniProtKB:Q8TBC4] synonym: "UBE1C" EXACT [UniProtKB:Q8TBC4] xref: EMBL:AB012190 xref: EMBL:AF046024 xref: EMBL:AL117566 xref: EMBL:BC022853 xref: HGNC:HGNC:12470 xref: UniGene:Hs.154320 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001989 ! UBA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006423 name: ASNS_human def: "Asparagine synthetase [glutamine-hydrolyzing] gene" [UniProtKB:P08243] synonym: "TS11" EXACT [UniProtKB:P08243] xref: EMBL:AC079781 xref: EMBL:BC008723 xref: EMBL:BC014621 xref: EMBL:BT007113 xref: EMBL:L35936 xref: EMBL:L35937 xref: EMBL:L35938 xref: EMBL:L35939 xref: EMBL:L35940 xref: EMBL:L35941 xref: EMBL:L35942 xref: EMBL:L35943 xref: EMBL:L35944 xref: EMBL:L35945 xref: EMBL:L35946 xref: EMBL:M15798 xref: EMBL:M27054 xref: EMBL:M27396 xref: HGNC:HGNC:753 xref: UniGene:Hs.489207 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0032819 ! ASNS_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006424 name: FOX1_human def: "Fox-1 homolog gene" [UniProtKB:Q9NWB1] synonym: "A2BP" EXACT [UniProtKB:Q9NWB1] synonym: "A2BP1" EXACT [UniProtKB:Q9NWB1] synonym: "HRNBP1" EXACT [UniProtKB:Q9NWB1] xref: EMBL:AF094849 xref: EMBL:AF107203 xref: EMBL:AF109106 xref: EMBL:AF109107 xref: EMBL:AF109108 xref: EMBL:AF109109 xref: EMBL:AF109110 xref: EMBL:AF109111 xref: EMBL:AF109112 xref: EMBL:AF109113 xref: EMBL:AF109114 xref: EMBL:AF109115 xref: EMBL:AF109116 xref: EMBL:AF109117 xref: EMBL:AF109118 xref: EMBL:AF109119 xref: EMBL:AF109120 xref: EMBL:AF229057 xref: EMBL:AF448859 xref: EMBL:AK001027 xref: EMBL:BC113691 xref: UniGene:Hs.459842 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0032832 ! FOX1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006425 name: PSMC3IP_human def: "Homologous-pairing protein 2 homolog gene" [UniProtKB:Q9P2W1] synonym: "HOP2" EXACT [UniProtKB:Q9P2W1] synonym: "TBPIP" EXACT [UniProtKB:Q9P2W1] xref: EMBL:AB030304 xref: EMBL:AF440240 xref: EMBL:BC008792 xref: EMBL:L38933 xref: HGNC:HGNC:17928 xref: UniGene:Hs.702050 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0032571 ! HOP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006426 name: MYH10_human def: "Myosin-10 gene" [UniProtKB:P35580] xref: EMBL:M69181 xref: EMBL:S67247 xref: EMBL:U15618 xref: HGNC:HGNC:7568 xref: UniGene:Hs.16355 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0019194 ! MYH10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006428 name: NAE1_human def: "NEDD8-activating enzyme E1 regulatory subunit gene" [UniProtKB:Q13564] synonym: "APPBP1" EXACT [UniProtKB:Q13564] synonym: "HPP1" EXACT [UniProtKB:Q13564] xref: EMBL:AC004638 xref: EMBL:AL136798 xref: EMBL:AY197612 xref: EMBL:BC000480 xref: EMBL:BC013301 xref: EMBL:U50939 xref: HGNC:HGNC:621 xref: UniGene:Hs.460978 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001758 ! ULA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0006429 name: ZNF318_human def: "Zinc finger protein 318 gene" [UniProtKB:Q5VUA4] synonym: "HRIHFB2436" EXACT [UniProtKB:Q5VUA4] xref: EMBL:AB015342 xref: EMBL:AF090114 xref: EMBL:AF121141 xref: EMBL:AL583834 xref: EMBL:AL590383 xref: EMBL:BC030687 xref: EMBL:BC098434 xref: HGNC:HGNC:13578 xref: UniGene:Hs.509718 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0032820 ! ZN318_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0007444 name: DBF4B_human def: "Protein DBF4 homolog B gene" [UniProtKB:Q8NFT6] synonym: "ASKL1" EXACT [UniProtKB:Q8NFT6] synonym: "DRF1" EXACT [UniProtKB:Q8NFT6] xref: EMBL:AF448801 xref: EMBL:AF465820 xref: EMBL:AK023149 xref: EMBL:BC016158 xref: EMBL:CH471178 xref: HGNC:HGNC:17883 xref: UniGene:Hs.369998 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0033478 ! DBF4B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0007828 name: MND1_human def: "Meiotic nuclear division protein 1 homolog gene" [UniProtKB:Q9BWT6] synonym: "GAJ" EXACT [UniProtKB:Q9BWT6] xref: EMBL:AY028916 xref: EMBL:BC032142 xref: EMBL:CH471056 xref: HGNC:HGNC:24839 xref: UniGene:Hs.294088 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0032873 ! MND1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0007855 name: MYH9_human def: "Myosin-9 gene" [UniProtKB:P35579] xref: EMBL:CR456526 xref: EMBL:M31013 xref: EMBL:M69180 xref: EMBL:M81105 xref: EMBL:Z82215 xref: HGNC:HGNC:7579 xref: UniGene:Hs.474751 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0019193 ! MYH9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008017 name: PSMA5_human def: "Proteasome subunit alpha type-5 gene" [UniProtKB:P28066] xref: EMBL:AL356735 xref: EMBL:AL390252 xref: EMBL:BC102018 xref: EMBL:BC102019 xref: EMBL:BC102020 xref: EMBL:BC103751 xref: EMBL:CR456847 xref: EMBL:X61970 xref: HGNC:HGNC:9534 xref: UniGene:Hs.485246 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0022204 ! PSA5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008019 name: PSMA7_human def: "Proteasome subunit alpha type-7 gene" [UniProtKB:O14818] xref: EMBL:AF022815 xref: EMBL:AF054185 xref: EMBL:AL078633 xref: EMBL:BC004427 xref: EMBL:BT007165 xref: HGNC:HGNC:9536 xref: UniGene:Hs.233952 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0030768 ! PSA7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008020 name: PSMB1_human def: "Proteasome subunit beta type-1 precursor gene" [UniProtKB:P20618] synonym: "PSC5" EXACT [UniProtKB:P20618] xref: EMBL:AL031259 xref: EMBL:BC000508 xref: EMBL:BC020807 xref: EMBL:BT019720 xref: EMBL:D00761 xref: HGNC:HGNC:9537 xref: UniGene:Hs.352768 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0030961 ! PSB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008021 name: PSMB2_human def: "Proteasome subunit beta type-2 gene" [UniProtKB:P49721] xref: EMBL:AL157951 xref: EMBL:AL354864 xref: EMBL:AL357035 xref: EMBL:BC101836 xref: EMBL:BC105126 xref: EMBL:BC107901 xref: EMBL:BT007137 xref: EMBL:CR456862 xref: EMBL:D26599 xref: HGNC:HGNC:9539 xref: UniGene:Hs.471441 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0030800 ! PSB2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008022 name: PSMB3_human def: "Proteasome subunit beta type-3 gene" [UniProtKB:P49720] xref: EMBL:BC002570 xref: EMBL:BC013008 xref: EMBL:D26598 xref: HGNC:HGNC:9540 xref: UniGene:Hs.82793 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0030929 ! PSB3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008023 name: PSMB6_human def: "Proteasome subunit beta type-6 precursor gene" [UniProtKB:P28072] synonym: "LMPY" EXACT [UniProtKB:P28072] xref: EMBL:BC000835 xref: EMBL:D29012 xref: EMBL:X61971 xref: HGNC:HGNC:9543 xref: UniGene:Hs.77060 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0031015 ! PSB6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008024 name: PSMB7_human def: "Proteasome subunit beta type-7 precursor gene" [UniProtKB:Q99436] xref: EMBL:BC000509 xref: EMBL:BC008414 xref: EMBL:BC017116 xref: EMBL:D38048 xref: HGNC:HGNC:9544 xref: UniGene:Hs.213470 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0034007 ! PSB7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008025 name: PSMB9_human def: "Proteasome subunit beta type-9 precursor gene" [UniProtKB:P28065] synonym: "LMP2" EXACT [UniProtKB:P28065] synonym: "RING12" EXACT [UniProtKB:P28065] xref: EMBL:AL669918 xref: EMBL:BC065513 xref: EMBL:S75169 xref: EMBL:U01025 xref: EMBL:X62741 xref: EMBL:X66401 xref: EMBL:X87344 xref: EMBL:Z14977 xref: HGNC:HGNC:9546 xref: UniGene:Hs.654585 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0031007 ! PSB9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008027 name: PSMD7_human def: "26S proteasome non-ATPase regulatory subunit 7 gene" [UniProtKB:P51665] synonym: "MOV34L" EXACT [UniProtKB:P51665] xref: EMBL:BC000338 xref: EMBL:BC012606 xref: EMBL:D50063 xref: HGNC:HGNC:9565 xref: UniGene:Hs.440604 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0031003 ! PSD7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008028 name: PSMD14_human def: "26S proteasome non-ATPase regulatory subunit 14 gene" [UniProtKB:O00487] synonym: "POH1" EXACT [UniProtKB:O00487] xref: EMBL:BC066336 xref: EMBL:U86782 xref: HGNC:HGNC:16889 xref: UniGene:Hs.567410 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0023606 ! PSDE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008033 name: PSMD3_human def: "26S proteasome non-ATPase regulatory subunit 3 gene" [UniProtKB:O43242] xref: EMBL:BC000074 xref: EMBL:BC004859 xref: EMBL:BC012302 xref: EMBL:BC020518 xref: EMBL:BC025686 xref: EMBL:BT007217 xref: EMBL:D67025 xref: HGNC:HGNC:9560 xref: UniGene:Hs.12970 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0021560 ! PSMD3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008034 name: PSMD6_human def: "26S proteasome non-ATPase regulatory subunit 6 gene" [UniProtKB:Q15008] synonym: "KIAA0107" EXACT [UniProtKB:Q15008] synonym: "PFAAP4" EXACT [UniProtKB:Q15008] xref: EMBL:AF215935 xref: EMBL:AF530062 xref: EMBL:AY568086 xref: EMBL:BC000630 xref: EMBL:BC000904 xref: EMBL:BC012369 xref: EMBL:D14663 xref: HGNC:HGNC:9564 xref: UniGene:Hs.152536 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0032651 ! PSMD6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008119 name: RORA_human def: "Nuclear receptor ROR-alpha gene" [UniProtKB:P35398] synonym: "NR1F1" EXACT [UniProtKB:P35398] synonym: "RZRA" EXACT [UniProtKB:P35398] xref: EMBL:BC008831 xref: EMBL:L14611 xref: EMBL:U04897 xref: EMBL:U04898 xref: EMBL:U04899 xref: HGNC:HGNC:10258 xref: UniGene:Hs.695914 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0019067 ! RORA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008330 name: UBE2D1_human def: "Ubiquitin-conjugating enzyme E2 D1 gene" [UniProtKB:P51668] synonym: "SFT" EXACT [UniProtKB:P51668] synonym: "UBCH5" EXACT [UniProtKB:P51668] synonym: "UBCH5A" EXACT [UniProtKB:P51668] xref: EMBL:AF020761 xref: EMBL:AF257220 xref: EMBL:AJ272367 xref: EMBL:AJ293565 xref: EMBL:BC005980 xref: EMBL:BC015997 xref: EMBL:BT007041 xref: EMBL:X78140 xref: HGNC:HGNC:12474 xref: UniGene:Hs.129683 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0019462 ! UB2D1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0008865 name: GSPT2_human def: "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B gene" [UniProtKB:Q8IYD1] synonym: "ERF3B" EXACT [UniProtKB:Q8IYD1] xref: EMBL:AJ251548 xref: EMBL:AK001303 xref: EMBL:AK023155 xref: EMBL:AL929101 xref: EMBL:BC036077 xref: EMBL:CH471230 xref: HGNC:HGNC:4622 xref: UniGene:Hs.59523 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041261 ! ERF3B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0010892 name: CASP8AP2_human def: "CASP8-associated protein 2 gene" [UniProtKB:Q9UKL3] synonym: "FLASH" EXACT [UniProtKB:Q9UKL3] synonym: "KIAA1315" EXACT [UniProtKB:Q9UKL3] synonym: "RIP25" EXACT [UniProtKB:Q9UKL3] xref: EMBL:AB037736 xref: EMBL:AF154415 xref: EMBL:AF164678 xref: EMBL:AF165161 xref: EMBL:AK002070 xref: EMBL:BC042577 xref: EMBL:BC056685 xref: HGNC:HGNC:1510 xref: UniGene:Hs.558218 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0035939 ! C8AP2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0010893 name: ERCC3_human def: "TFIIH basal transcription factor complex helicase XPB subunit gene" [UniProtKB:P19447] synonym: "XPB" EXACT [UniProtKB:P19447] synonym: "XPBC" EXACT [UniProtKB:P19447] xref: EMBL:AY163769 xref: EMBL:BC008820 xref: EMBL:M31899 xref: HGNC:HGNC:3435 xref: UniGene:Hs.469872 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0028502 ! ERCC3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0010894 name: KANK1_human def: "KN motif and ankyrin repeat domain-containing protein 1 gene" [UniProtKB:Q14678] synonym: "ANKRD15" EXACT [UniProtKB:Q14678] synonym: "KANK" EXACT [UniProtKB:Q14678] synonym: "KIAA0172" EXACT [UniProtKB:Q14678] xref: EMBL:AL136979 xref: EMBL:BC037495 xref: EMBL:D79994 xref: HGNC:HGNC:19309 xref: UniGene:Hs.306764 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0001789 ! KANK1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0010895 name: MEN1_human def: "Menin gene" [UniProtKB:O00255] synonym: "SCG2" EXACT [UniProtKB:O00255] xref: EMBL:BC002544 xref: EMBL:U93236 xref: EMBL:U93237 xref: HGNC:HGNC:7010 xref: UniGene:Hs.423348 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0035935 ! MEN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0010896 name: RBM38_human def: "RNA-binding protein 38 gene" [UniProtKB:Q9H0Z9] synonym: "RNPC1" EXACT [UniProtKB:Q9H0Z9] synonym: "SEB4" EXACT [UniProtKB:Q9H0Z9] xref: EMBL:AF432218 xref: EMBL:AL109955 xref: EMBL:BC018711 xref: EMBL:X75314 xref: EMBL:X75315 xref: HGNC:HGNC:15818 xref: UniGene:Hs.236361 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0017902 ! RBM38_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0010897 name: RNF8_human def: "E3 ubiquitin-protein ligase RNF8 gene" [UniProtKB:O76064] synonym: "KIAA0646" EXACT [UniProtKB:O76064] xref: EMBL:AB012770 xref: EMBL:AB014546 xref: EMBL:AF334675 xref: EMBL:AK222765 xref: EMBL:AL096712 xref: EMBL:BC007517 xref: EMBL:BT007446 xref: EMBL:CH471081 xref: HGNC:HGNC:10071 xref: UniGene:Hs.485278 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0035936 ! RNF8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0010898 name: SETD8_human def: "Histone-lysine N-methyltransferase SETD8 gene" [UniProtKB:Q9NQR1] synonym: "KMT5A" EXACT [UniProtKB:Q9NQR1] synonym: "PRSET7" EXACT [UniProtKB:Q9NQR1] synonym: "SET07" EXACT [UniProtKB:Q9NQR1] synonym: "SET8" EXACT [UniProtKB:Q9NQR1] xref: EMBL:AF287261 xref: EMBL:AY064546 xref: EMBL:AY102937 xref: EMBL:BC050346 xref: HGNC:HGNC:29489 xref: UniGene:Hs.572262 xref: UniGene:Hs.700682 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0035938 ! SETD8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0010899 name: SKP1_human def: "S-phase kinase-associated protein 1 gene" [UniProtKB:P63208] synonym: "EMC19" EXACT [UniProtKB:P63208] synonym: "OCP2" EXACT [UniProtKB:P63208] synonym: "SKP1A" EXACT [UniProtKB:P63208] synonym: "TCEB1L" EXACT [UniProtKB:P63208] xref: EMBL:BC009839 xref: EMBL:BC020798 xref: EMBL:BC025673 xref: EMBL:BC065730 xref: EMBL:U33760 xref: EMBL:U37558 xref: EMBL:Z47087 xref: HGNC:HGNC:10899 xref: UniGene:Hs.171626 xref: UniGene:Hs.643015 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005634 ! SKP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0011243 name: PRMT6_human def: "Protein arginine N-methyltransferase 6 gene" [UniProtKB:Q96LA8] synonym: "HRMT1L6" EXACT [UniProtKB:Q96LA8] xref: EMBL:AK001421 xref: EMBL:AL355539 xref: EMBL:AY043278 xref: EMBL:BC002729 xref: EMBL:BC073866 xref: EMBL:CH471156 xref: HGNC:HGNC:18241 xref: UniGene:Hs.26006 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0036272 ! ANM6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0011455 name: HCFC2_human def: "Host cell factor 2 gene" [UniProtKB:Q9Y5Z7] xref: EMBL:AF117210 xref: EMBL:BC033799 xref: HGNC:HGNC:24972 xref: UniGene:Hs.506558 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0036469 ! HCFC2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0011629 name: PSMC6_human def: "26S protease regulatory subunit S10B gene" [UniProtKB:P62333] synonym: "SUG2" EXACT [UniProtKB:P62333] xref: EMBL:AF006305 xref: EMBL:BC005390 xref: EMBL:BT006843 xref: EMBL:CR456709 xref: EMBL:D78275 xref: HGNC:HGNC:9553 xref: UniGene:Hs.156171 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0030905 ! PRS10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0011631 name: PSMB5_human def: "Proteasome subunit beta type-5 precursor gene" [UniProtKB:P28074] synonym: "LMPX" EXACT [UniProtKB:P28074] xref: EMBL:BC004146 xref: EMBL:BC057840 xref: EMBL:BC107720 xref: EMBL:BT006777 xref: EMBL:BX538001 xref: EMBL:D29011 xref: EMBL:S74378 xref: EMBL:X95586 xref: HGNC:HGNC:9542 xref: UniGene:Hs.422990 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0030806 ! PSB5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0011632 name: PSMB8_human def: "Proteasome subunit beta type-8 precursor gene" [UniProtKB:P28062] synonym: "LMP7" EXACT [UniProtKB:P28062] synonym: "RING10" EXACT [UniProtKB:P28062] synonym: "Y2" EXACT [UniProtKB:P28062] xref: EMBL:AL669918 xref: EMBL:AL671681 xref: EMBL:AL935043 xref: EMBL:BC001114 xref: EMBL:BX088556 xref: EMBL:BX682530 xref: EMBL:BX927138 xref: EMBL:CR762476 xref: EMBL:CT009502 xref: EMBL:L11045 xref: EMBL:U17496 xref: EMBL:U17497 xref: EMBL:U32862 xref: EMBL:U32863 xref: EMBL:X62598 xref: EMBL:X66401 xref: EMBL:X87344 xref: EMBL:Z14982 xref: HGNC:HGNC:9545 xref: UniGene:Hs.180062 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0030804 ! PSB8_HUMAN relationship: codes_for CCO:B0030810 ! Q5JNW7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0011633 name: PSMD12_human def: "26S proteasome non-ATPase regulatory subunit 12 gene" [UniProtKB:O00232] xref: EMBL:AB003103 xref: EMBL:AK222679 xref: EMBL:BC019062 xref: EMBL:BC065826 xref: HGNC:HGNC:9557 xref: UniGene:Hs.646575 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0038144 ! PSD12_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0011851 name: HMGA2_human def: "High mobility group protein HMGI-C gene" [UniProtKB:P52926] synonym: "HMGIC" EXACT [UniProtKB:P52926] xref: EMBL:L41044 xref: EMBL:L44578 xref: EMBL:L46353 xref: EMBL:U28749 xref: EMBL:U28750 xref: EMBL:U28751 xref: EMBL:U28752 xref: EMBL:U28753 xref: EMBL:U28754 xref: EMBL:X92518 xref: EMBL:Z31595 xref: HGNC:HGNC:5009 xref: UniGene:Hs.505924 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041249 ! HMGA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0012897 name: EXOSC2_human def: "Exosome complex exonuclease RRP4 gene" [UniProtKB:Q13868] synonym: "RRP4" EXACT [UniProtKB:Q13868] xref: EMBL:AK001916 xref: EMBL:AK022460 xref: EMBL:BC000747 xref: EMBL:U07561 xref: HGNC:HGNC:17097 xref: UniGene:Hs.654643 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039757 ! EXOS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0012898 name: FEN1_human def: "Flap endonuclease 1 gene" [UniProtKB:P39748] synonym: "RAD2" EXACT [UniProtKB:P39748] xref: EMBL:AC004770 xref: EMBL:AF523117 xref: EMBL:BC000323 xref: EMBL:L37374 xref: EMBL:X76771 xref: HGNC:HGNC:3650 xref: UniGene:Hs.409065 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039756 ! FEN1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0012899 name: SLC26A8_human def: "Testis anion transporter 1 gene" [UniProtKB:Q96RN1] synonym: "TAT1" EXACT [UniProtKB:Q96RN1] xref: EMBL:AF314959 xref: EMBL:AF331522 xref: EMBL:AF403499 xref: EMBL:AK057276 xref: EMBL:AL133507 xref: EMBL:BC025408 xref: EMBL:CH471081 xref: EMBL:Z95152 xref: HGNC:HGNC:14468 xref: UniGene:Hs.435836 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0035937 ! S26A8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0012900 name: UTP18_human def: "U3 small nucleolar RNA-associated protein 18 homolog gene" [UniProtKB:Q9Y5J1] synonym: "CDABP0061" EXACT [UniProtKB:Q9Y5J1] synonym: "CGI-48" EXACT [UniProtKB:Q9Y5J1] synonym: "WDR50" EXACT [UniProtKB:Q9Y5J1] xref: EMBL:AF151806 xref: EMBL:AY007138 xref: EMBL:BC025276 xref: HGNC:HGNC:24274 xref: UniGene:Hs.463456 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039758 ! UTP18_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0012992 name: CREBL2_human def: "cAMP-responsive element-binding protein-like 2 gene" [UniProtKB:O60519] xref: EMBL:AF039081 xref: EMBL:BC104873 xref: EMBL:BC106052 xref: EMBL:BC112157 xref: EMBL:CH471094 xref: EMBL:CR542250 xref: HGNC:HGNC:2350 xref: UniGene:Hs.591156 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039945 ! CRBL2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0012994 name: FSD1_human def: "Fibronectin type III and SPRY domain-containing protein 1 gene" [UniProtKB:Q9BTV5] synonym: "GLFND" EXACT [UniProtKB:Q9BTV5] synonym: "MIR1" EXACT [UniProtKB:Q9BTV5] synonym: "VLP27" EXACT [UniProtKB:Q9BTV5] xref: EMBL:AF316829 xref: EMBL:AK021750 xref: EMBL:AY032617 xref: EMBL:BC003124 xref: HGNC:HGNC:13745 xref: UniGene:Hs.28144 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039949 ! FSD1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0012995 name: NPAT_human def: "Protein NPAT gene" [UniProtKB:Q14207] synonym: "CAND3" EXACT [UniProtKB:Q14207] synonym: "E14" EXACT [UniProtKB:Q14207] xref: EMBL:AK290020 xref: EMBL:AK291687 xref: EMBL:BC040356 xref: EMBL:BC050561 xref: EMBL:D83243 xref: EMBL:D89854 xref: EMBL:U58852 xref: EMBL:X97186 xref: HGNC:HGNC:7896 xref: UniGene:Hs.171061 xref: UniGene:Hs.367437 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039946 ! NPAT_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0012996 name: STRA8_human def: "Stimulated by retinoic acid gene 8 protein homolog gene" [UniProtKB:Q7Z7C7] xref: EMBL:AF513502 xref: EMBL:CH236950 xref: EMBL:CH471070 xref: HGNC:HGNC:30653 xref: UniGene:Hs.592279 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039947 ! STRA8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0012997 name: ZFP42_human def: "Zinc finger protein 42 homolog gene" [UniProtKB:Q96MM3] synonym: "REX1" EXACT [UniProtKB:Q96MM3] synonym: "ZNF754" EXACT [UniProtKB:Q96MM3] xref: EMBL:AF450454 xref: EMBL:AK056719 xref: EMBL:AY429593 xref: HGNC:HGNC:30949 xref: UniGene:Hs.335787 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039948 ! ZFP42_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013022 name: PPP1R16A_human def: "Protein phosphatase 1 regulatory subunit 16A gene" [UniProtKB:Q96I34] synonym: "MYPT3" EXACT [UniProtKB:Q96I34] xref: EMBL:AK090471 xref: EMBL:BC007854 xref: EMBL:BC049841 xref: EMBL:BC053506 xref: EMBL:BT006845 xref: HGNC:HGNC:14941 xref: UniGene:Hs.521937 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039979 ! PP16A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013372 name: CHPF_human def: "Chondroitin sulfate synthase 2 gene" [UniProtKB:Q8IZ52] synonym: "CSS2" EXACT [UniProtKB:Q8IZ52] synonym: "UNQ651/PRO1281" EXACT [UniProtKB:Q8IZ52] xref: EMBL:AB086063 xref: EMBL:AB095813 xref: EMBL:AK026331 xref: EMBL:AL136814 xref: EMBL:AY358403 xref: EMBL:BC008878 xref: EMBL:BC021223 xref: EMBL:BC023531 xref: HGNC:HGNC:24291 xref: UniGene:Hs.516711 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0006320 ! CHSS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013373 name: CUX1_human def: "Homeobox protein cut-like 1 gene" [UniProtKB:P39880] synonym: "CUTL1" EXACT [UniProtKB:P39880] xref: EMBL:AF047825 xref: EMBL:BC066592 xref: EMBL:M74099 xref: HGNC:HGNC:2557 xref: UniGene:Hs.654389 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0040687 ! CUX1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013374 name: DSCC1_human def: "Sister chromatid cohesion protein DCC1 gene" [UniProtKB:Q9BVC3] synonym: "DCC1" EXACT [UniProtKB:Q9BVC3] synonym: "UNQ9337/PRO34008" EXACT [UniProtKB:Q9BVC3] xref: EMBL:AK054585 xref: EMBL:AY358866 xref: EMBL:BC001316 xref: EMBL:BC001531 xref: HGNC:HGNC:24453 xref: UniGene:Hs.315167 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0039950 ! DCC1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013375 name: GABPB1_human def: "GA-binding protein subunit beta-1 gene" [UniProtKB:Q06547] synonym: "E4TF1B" EXACT [UniProtKB:Q06547] synonym: "GABPB" EXACT [UniProtKB:Q06547] synonym: "GABPB2" EXACT [UniProtKB:Q06547] xref: EMBL:BC016910 xref: EMBL:BC036080 xref: EMBL:BC050702 xref: EMBL:BT006652 xref: EMBL:D13316 xref: EMBL:D13317 xref: EMBL:U13045 xref: EMBL:U13046 xref: EMBL:U13047 xref: EMBL:U13048 xref: HGNC:HGNC:4074 xref: UniGene:Hs.654350 xref: UniGene:Hs.659360 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0040683 ! GABP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013377 name: HTT_human def: "Huntingtin gene" [UniProtKB:P42858] synonym: "HD" EXACT [UniProtKB:P42858] synonym: "IT15" EXACT [UniProtKB:P42858] xref: EMBL:AB016794 xref: EMBL:L12392 xref: EMBL:L20431 xref: EMBL:L27350 xref: EMBL:L27351 xref: EMBL:L27352 xref: EMBL:L27353 xref: EMBL:L27354 xref: EMBL:L34020 xref: EMBL:Z49154 xref: EMBL:Z49155 xref: EMBL:Z49208 xref: EMBL:Z49769 xref: EMBL:Z68756 xref: EMBL:Z69649 xref: HGNC:HGNC:4851 xref: UniGene:Hs.518450 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0005407 ! HD_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013383 name: CCNDBP1_human def: "Cyclin-D1-binding protein 1 gene" [UniProtKB:O95273] synonym: "DIP1" EXACT [UniProtKB:O95273] synonym: "GCIP" EXACT [UniProtKB:O95273] synonym: "HHM" EXACT [UniProtKB:O95273] xref: EMBL:AF082569 xref: EMBL:AF087852 xref: EMBL:AF113535 xref: EMBL:AF132034 xref: EMBL:AF246144 xref: EMBL:AK075146 xref: EMBL:AK075296 xref: EMBL:AK128849 xref: EMBL:AK290665 xref: EMBL:AK290707 xref: EMBL:BC009689 xref: EMBL:CH471125 xref: EMBL:CR450331 xref: HGNC:HGNC:1587 xref: UniGene:Hs.36794 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041241 ! CCDB1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013384 name: CINP_human def: "Cyclin-dependent kinase 2-interacting protein gene" [UniProtKB:Q9BW66] xref: EMBL:AF228148 xref: EMBL:AF228149 xref: EMBL:AK056112 xref: EMBL:BC000600 xref: EMBL:CH471061 xref: EMBL:CR457178 xref: UniGene:Hs.129634 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041266 ! CINP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013385 name: NCAPH2_human def: "Condensin-2 complex subunit H2 gene" [UniProtKB:Q6IBW4] synonym: "CAPH2" EXACT [UniProtKB:Q6IBW4] xref: EMBL:AL021682 xref: EMBL:BC000473 xref: EMBL:BC001298 xref: EMBL:BC001509 xref: EMBL:BC001833 xref: EMBL:BC001937 xref: EMBL:BC009441 xref: EMBL:BC014939 xref: EMBL:CH471138 xref: EMBL:CR456604 xref: EMBL:U62317 xref: HGNC:HGNC:25071 xref: UniGene:Hs.180903 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041259 ! CNDH2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013386 name: CTF8_human def: "Chromosome transmission fidelity protein 8 gene" [UniProtKB:Q8WV66] xref: EMBL:AC009027 xref: EMBL:BC018700 xref: UniGene:Hs.85962 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041262 ! CTF8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013387 name: DMTF1_human def: "Cyclin-D-binding Myb-like transcription factor 1 gene" [UniProtKB:Q9Y222] synonym: "DMP1" EXACT [UniProtKB:Q9Y222] xref: EMBL:AB209230 xref: EMBL:AC005076 xref: EMBL:AF084530 xref: EMBL:AF202144 xref: EMBL:AF202145 xref: EMBL:AK126664 xref: EMBL:BC007418 xref: EMBL:BC007447 xref: EMBL:BC029370 xref: EMBL:BC070064 xref: EMBL:CH471091 xref: HGNC:HGNC:14603 xref: UniGene:Hs.654981 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041267 ! DMTF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013388 name: E4F1_human def: "Transcription factor E4F1 gene" [UniProtKB:Q66K89] synonym: "E4F" EXACT [UniProtKB:Q66K89] xref: EMBL:AK290329 xref: EMBL:BC080524 xref: EMBL:CH471112 xref: EMBL:U87269 xref: HGNC:HGNC:3121 xref: UniGene:Hs.513268 xref: UniGene:Hs.615283 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041257 ! E4F1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013389 name: ERCC6L_human def: "DNA excision repair protein ERCC-6-like gene" [UniProtKB:Q2NKX8] synonym: "PICH" EXACT [UniProtKB:Q2NKX8] xref: EMBL:AK000112 xref: EMBL:AK074719 xref: EMBL:AY121802 xref: EMBL:BC008808 xref: EMBL:BC111486 xref: EMBL:EU069463 xref: HGNC:HGNC:20794 xref: UniGene:Hs.47558 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041256 ! ERC6L_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013390 name: GUSBP1_human def: "Beta-glucuronidase-like protein SMA3 gene" [UniProtKB:Q15486] synonym: "SMA3" EXACT [UniProtKB:Q15486] xref: EMBL:AL009030 xref: EMBL:BC002622 xref: EMBL:BC050737 xref: EMBL:BT006760 xref: EMBL:X83299 xref: HGNC:HGNC:13670 xref: UniGene:Hs.529793 xref: UniGene:Hs.654587 xref: UniGene:Hs.654588 xref: UniGene:Hs.675815 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041277 ! GUSP1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013391 name: MAPK1IP1L_human def: "MAPK-interacting and spindle-stabilizing protein-like gene" [UniProtKB:Q8NDC0] synonym: "C14orf32" EXACT [UniProtKB:Q8NDC0] xref: EMBL:AL139316 xref: EMBL:AL834285 xref: EMBL:BC015621 xref: HGNC:HGNC:19840 xref: UniGene:Hs.594338 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041276 ! MISSL_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013392 name: MTBP_human def: "Mdm2-binding protein gene" [UniProtKB:Q96DY7] xref: EMBL:AK022122 xref: EMBL:BC013136 xref: EMBL:CH471060 xref: HGNC:HGNC:7417 xref: UniGene:Hs.657656 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041265 ! MTBP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013393 name: PRKCDBP_human def: "Protein kinase C delta-binding protein gene" [UniProtKB:Q969G5] synonym: "SRBC" EXACT [UniProtKB:Q969G5] xref: EMBL:AF339881 xref: EMBL:AF408198 xref: EMBL:BC011585 xref: EMBL:CH471064 xref: HGNC:HGNC:9400 xref: UniGene:Hs.434044 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041264 ! PRDBP_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013394 name: PSMC3_human def: "26S protease regulatory subunit 6A gene" [UniProtKB:P17980] synonym: "TBP1" EXACT [UniProtKB:P17980] xref: EMBL:AK222485 xref: EMBL:BC008713 xref: EMBL:BC073165 xref: EMBL:BC106920 xref: EMBL:BC107804 xref: EMBL:CR456731 xref: EMBL:M34079 xref: HGNC:HGNC:9549 xref: UniGene:Hs.250758 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041242 ! PRS6A_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013395 name: PSMC4_human def: "26S protease regulatory subunit 6B gene" [UniProtKB:P43686] synonym: "MIP224" EXACT [UniProtKB:P43686] synonym: "TBP7" EXACT [UniProtKB:P43686] xref: EMBL:AC007842 xref: EMBL:AF020736 xref: EMBL:AF038965 xref: EMBL:BC000343 xref: EMBL:BC010396 xref: EMBL:BC014488 xref: EMBL:BT007232 xref: EMBL:U27515 xref: HGNC:HGNC:9551 xref: UniGene:Hs.211594 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041247 ! PRS6B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013396 name: PSMC2_human def: "26S protease regulatory subunit 7 gene" [UniProtKB:P35998] synonym: "MSS1" EXACT [UniProtKB:P35998] xref: EMBL:BC002589 xref: EMBL:D11094 xref: HGNC:HGNC:9548 xref: UniGene:Hs.437366 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041246 ! PRS7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013397 name: PSMC5_human def: "26S protease regulatory subunit 8 gene" [UniProtKB:P62195] synonym: "SUG1" EXACT [UniProtKB:P62195] xref: EMBL:AF035309 xref: EMBL:BC001932 xref: EMBL:BC002367 xref: EMBL:D44467 xref: EMBL:L38810 xref: HGNC:HGNC:9552 xref: UniGene:Hs.79387 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041253 ! PRS8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013398 name: PSMA2_human def: "Proteasome subunit alpha type-2 gene" [UniProtKB:P25787] synonym: "PSC3" EXACT [UniProtKB:P25787] xref: EMBL:BC002900 xref: EMBL:BC047697 xref: EMBL:D00760 xref: HGNC:HGNC:9531 xref: UniGene:Hs.333786 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041243 ! PSA2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013399 name: PSMA4_human def: "Proteasome subunit alpha type-4 gene" [UniProtKB:P25789] synonym: "PSC9" EXACT [UniProtKB:P25789] xref: EMBL:BC005361 xref: EMBL:BC022445 xref: EMBL:BC022817 xref: EMBL:BC047667 xref: EMBL:D00763 xref: HGNC:HGNC:9533 xref: UniGene:Hs.251531 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041244 ! PSA4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013400 name: PSMA6_human def: "Proteasome subunit alpha type-6 gene" [UniProtKB:P60900] synonym: "PROS27" EXACT [UniProtKB:P60900] xref: EMBL:BC002979 xref: EMBL:BC017882 xref: EMBL:BC022354 xref: EMBL:BC023659 xref: EMBL:BC070137 xref: EMBL:CR456944 xref: EMBL:X59417 xref: EMBL:X61972 xref: HGNC:HGNC:9535 xref: UniGene:Hs.446260 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041251 ! PSA6_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013401 name: PSMB4_human def: "Proteasome subunit beta type-4 precursor gene" [UniProtKB:P28070] xref: EMBL:BC000331 xref: EMBL:BC008314 xref: EMBL:BC010088 xref: EMBL:BC010098 xref: EMBL:BC011768 xref: EMBL:BC012168 xref: EMBL:BC017307 xref: EMBL:BC017451 xref: EMBL:BC017486 xref: EMBL:BT006917 xref: EMBL:D26600 xref: EMBL:S71381 xref: HGNC:HGNC:9541 xref: UniGene:Hs.89545 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041245 ! PSB4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013402 name: PSMD10_human def: "26S proteasome non-ATPase regulatory subunit 10 gene" [UniProtKB:O75832] xref: EMBL:AB009619 xref: EMBL:AL031177 xref: EMBL:BC011960 xref: EMBL:D83197 xref: HGNC:HGNC:9555 xref: UniGene:Hs.522752 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041240 ! PSD10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013403 name: PSMD4_human def: "26S proteasome non-ATPase regulatory subunit 4 gene" [UniProtKB:P55036] synonym: "MCB1" EXACT [UniProtKB:P55036] xref: EMBL:AB033605 xref: EMBL:AL391069 xref: EMBL:AL592424 xref: EMBL:BC002365 xref: EMBL:BC072008 xref: EMBL:U24704 xref: EMBL:U51007 xref: EMBL:U72664 xref: HGNC:HGNC:9561 xref: UniGene:Hs.505059 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041250 ! PSMD4_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013404 name: PSMD5_human def: "26S proteasome non-ATPase regulatory subunit 5 gene" [UniProtKB:Q16401] synonym: "KIAA0072" EXACT [UniProtKB:Q16401] xref: EMBL:BC014478 xref: EMBL:D31889 xref: EMBL:S79862 xref: HGNC:HGNC:9563 xref: UniGene:Hs.193725 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041255 ! PSMD5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013405 name: PSMD9_human def: "26S proteasome non-ATPase regulatory subunit 9 gene" [UniProtKB:O00233] xref: EMBL:AB003177 xref: EMBL:BC002383 xref: EMBL:BC004184 xref: EMBL:BC004213 xref: HGNC:HGNC:9567 xref: UniGene:Hs.131151 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041239 ! PSMD9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013406 name: PSME3_human def: "Proteasome activator complex subunit 3 gene" [UniProtKB:P61289] xref: EMBL:BC001423 xref: EMBL:BC002684 xref: EMBL:BC008020 xref: EMBL:BT019386 xref: EMBL:U11292 xref: EMBL:U25756 xref: HGNC:HGNC:9570 xref: UniGene:Hs.152978 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041252 ! PSME3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013407 name: PSMF1_human def: "Proteasome inhibitor PI31 subunit gene" [UniProtKB:Q92530] xref: EMBL:AL031665 xref: EMBL:BC126462 xref: EMBL:D88378 xref: HGNC:HGNC:9571 xref: UniGene:Hs.471917 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041263 ! PSMF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013408 name: PROTOR1_human def: "Protor-1 gene" [UniProtKB:P85299] synonym: "PP610" EXACT [UniProtKB:P85299] synonym: "PRR5" EXACT [UniProtKB:P85299] xref: EMBL:AF177331 xref: EMBL:AK000192 xref: EMBL:BC016921 xref: EMBL:BK005635 xref: EMBL:BK005636 xref: EMBL:BK005637 xref: EMBL:BK005638 xref: EMBL:BK005639 xref: EMBL:Z93244 xref: EMBL:Z98743 xref: HGNC:HGNC:31682 xref: UniGene:Hs.102336 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041254 ! PTOR1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013409 name: TMEM90B_human def: "Transmembrane protein 90B gene" [UniProtKB:Q9H7V2] synonym: "C20orf39" EXACT [UniProtKB:Q9H7V2] xref: EMBL:AK024282 xref: EMBL:AL049594 xref: EMBL:AL157413 xref: EMBL:BC030637 xref: EMBL:CR457325 xref: HGNC:HGNC:15885 xref: UniGene:Hs.124638 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041279 ! TM90B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013410 name: UBE2E1_human def: "Ubiquitin-conjugating enzyme E2 E1 gene" [UniProtKB:P51965] synonym: "UBCH6" EXACT [UniProtKB:P51965] xref: EMBL:BC009139 xref: EMBL:X92963 xref: HGNC:HGNC:12477 xref: UniGene:Hs.164853 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041248 ! UB2E1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013411 name: USP22_human def: "Ubiquitin carboxyl-terminal hydrolase 22 gene" [UniProtKB:Q9UPT9] synonym: "KIAA1063" EXACT [UniProtKB:Q9UPT9] synonym: "USP3L" EXACT [UniProtKB:Q9UPT9] xref: EMBL:AB028986 xref: HGNC:HGNC:12621 xref: UniGene:Hs.462492 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0024005 ! UBP22_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0013412 name: XAF1_human def: "XIAP-associated factor 1 gene" [UniProtKB:Q6GPH4] synonym: "BIRC4BP" EXACT [UniProtKB:Q6GPH4] synonym: "XIAPAF1" EXACT [UniProtKB:Q6GPH4] xref: EMBL:AK290276 xref: EMBL:AK292710 xref: EMBL:AK292848 xref: EMBL:BC032776 xref: EMBL:BC073156 xref: EMBL:BX649188 xref: EMBL:CH471108 xref: EMBL:EF028165 xref: EMBL:EF028166 xref: EMBL:X99699 xref: HGNC:HGNC:30932 xref: UniGene:Hs.441975 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0041258 ! XAF1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014149 name: BBS2_human def: "Bardet-Biedl syndrome 2 protein gene" [UniProtKB:Q9BXC9] xref: EMBL:AF342736 xref: EMBL:AK027635 xref: EMBL:BC014140 xref: HGNC:HGNC:967 xref: UniGene:Hs.333738 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043419 ! BBS2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014150 name: C1orf216_human def: "UPF0500 protein C1orf216 gene" [UniProtKB:Q8TAB5] xref: EMBL:AK096303 xref: EMBL:AK096466 xref: EMBL:BC026909 xref: EMBL:CH471059 xref: HGNC:HGNC:26800 xref: UniGene:Hs.112023 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043422 ! CA216_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014151 name: CBWD3_human def: "COBW domain-containing protein 3 gene" [UniProtKB:Q5JTY5] xref: EMBL:AL353608 xref: HGNC:HGNC:18519 xref: UniGene:Hs.597638 xref: UniGene:Hs.645337 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043444 ! CBWD3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014152 name: CENTA1_human def: "Centaurin-alpha-1 gene" [UniProtKB:O75689] xref: EMBL:AB097049 xref: EMBL:AF082324 xref: EMBL:AJ006422 xref: EMBL:BC033747 xref: HGNC:HGNC:16486 xref: UniGene:Hs.644629 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043443 ! CENA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014153 name: CLUAP1_human def: "Clusterin-associated protein 1 gene" [UniProtKB:Q96AJ1] synonym: "KIAA0643" EXACT [UniProtKB:Q96AJ1] xref: EMBL:AB014543 xref: EMBL:AB089691 xref: EMBL:AK023319 xref: EMBL:AK023359 xref: EMBL:BC017070 xref: HGNC:HGNC:19009 xref: UniGene:Hs.155995 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043416 ! CLUA1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014154 name: DDX19B_human def: "ATP-dependent RNA helicase DDX19B gene" [UniProtKB:Q9UMR2] synonym: "DBP5" EXACT [UniProtKB:Q9UMR2] synonym: "DDX19" EXACT [UniProtKB:Q9UMR2] xref: EMBL:AJ237946 xref: EMBL:AL136639 xref: EMBL:BC003626 xref: EMBL:CH471241 xref: EMBL:CR457215 xref: EMBL:CR533509 xref: HGNC:HGNC:2742 xref: UniGene:Hs.221761 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043447 ! DD19B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014155 name: EZH2_human def: "Enhancer of zeste homolog 2 gene" [UniProtKB:Q15910] synonym: "KMT6" EXACT [UniProtKB:Q15910] xref: EMBL:U52965 xref: EMBL:U61145 xref: EMBL:X95653 xref: HGNC:HGNC:3527 xref: UniGene:Hs.444082 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043441 ! EZH2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014156 name: FBXO34_human def: "F-box only protein 34 gene" [UniProtKB:Q9NWN3] synonym: "FBX34" EXACT [UniProtKB:Q9NWN3] xref: EMBL:AK000732 xref: EMBL:BC109120 xref: EMBL:BC109121 xref: EMBL:BX248268 xref: EMBL:CR457249 xref: HGNC:HGNC:20201 xref: UniGene:Hs.525348 xref: UniGene:Hs.654725 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043442 ! FBX34_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014157 name: FBXO41_human def: "F-box only protein 41 gene" [UniProtKB:Q8TF61] synonym: "FBX41" EXACT [UniProtKB:Q8TF61] synonym: "KIAA1940" EXACT [UniProtKB:Q8TF61] xref: EMBL:AB075820 xref: EMBL:AC010913 xref: HGNC:HGNC:29409 xref: UniGene:Hs.23158 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043435 ! FBX41_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014158 name: FBXL7_human def: "F-box/LRR-repeat protein 7 gene" [UniProtKB:Q9UJT9] synonym: "FBL6" EXACT [UniProtKB:Q9UJT9] synonym: "FBL7" EXACT [UniProtKB:Q9UJT9] synonym: "KIAA0840" EXACT [UniProtKB:Q9UJT9] xref: EMBL:AB020647 xref: EMBL:AF174593 xref: EMBL:AF199356 xref: EMBL:BC075061 xref: HGNC:HGNC:13604 xref: UniGene:Hs.433057 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043431 ! FBXL7_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014159 name: FBXW2_human def: "F-box/WD repeat-containing protein 2 gene" [UniProtKB:Q9UKT8] synonym: "FBW2" EXACT [UniProtKB:Q9UKT8] synonym: "FWD2" EXACT [UniProtKB:Q9UKT8] xref: EMBL:AF129531 xref: EMBL:AF145024 xref: EMBL:AF176698 xref: EMBL:AF193594 xref: EMBL:AK022484 xref: EMBL:AL161911 xref: EMBL:BC018738 xref: EMBL:BC110334 xref: HGNC:HGNC:13608 xref: UniGene:Hs.494985 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043432 ! FBXW2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014160 name: FBXW5_human def: "F-box/WD repeat-containing protein 5 gene" [UniProtKB:Q969U6] synonym: "FBW5" EXACT [UniProtKB:Q969U6] synonym: "PP3971" EXACT [UniProtKB:Q969U6] xref: EMBL:AF217998 xref: EMBL:AF258569 xref: EMBL:AK026081 xref: EMBL:AL137631 xref: EMBL:AL807752 xref: EMBL:BC000850 xref: EMBL:BC004541 xref: EMBL:BC009429 xref: EMBL:BC014130 xref: EMBL:BC014297 xref: HGNC:HGNC:13613 xref: UniGene:Hs.522507 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043433 ! FBXW5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014161 name: FBXW8_human def: "F-box/WD repeat-containing protein 8 gene" [UniProtKB:Q8N3Y1] synonym: "FBW6" EXACT [UniProtKB:Q8N3Y1] synonym: "FBW8" EXACT [UniProtKB:Q8N3Y1] synonym: "FBX29" EXACT [UniProtKB:Q8N3Y1] synonym: "FBXO29" EXACT [UniProtKB:Q8N3Y1] synonym: "FBXW6" EXACT [UniProtKB:Q8N3Y1] xref: EMBL:AF176707 xref: EMBL:BC037296 xref: HGNC:HGNC:13597 xref: UniGene:Hs.624537 xref: UniGene:Hs.696428 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043434 ! FBXW8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014162 name: HEXA_human def: "Beta-hexosaminidase subunit alpha precursor gene" [UniProtKB:P06865] xref: EMBL:BC018927 xref: EMBL:BC084537 xref: EMBL:M13520 xref: EMBL:M16411 xref: EMBL:M16412 xref: EMBL:M16413 xref: EMBL:M16414 xref: EMBL:M16415 xref: EMBL:M16416 xref: EMBL:M16417 xref: EMBL:M16418 xref: EMBL:M16419 xref: EMBL:M16420 xref: EMBL:M16421 xref: EMBL:M16422 xref: EMBL:M16423 xref: EMBL:M16424 xref: EMBL:S62047 xref: EMBL:S62049 xref: EMBL:S62051 xref: EMBL:S62053 xref: EMBL:S62055 xref: EMBL:S62057 xref: EMBL:S62059 xref: EMBL:S62061 xref: EMBL:S62063 xref: EMBL:S62066 xref: EMBL:S62068 xref: EMBL:S62070 xref: EMBL:S62072 xref: EMBL:S62076 xref: HGNC:HGNC:4878 xref: UniGene:Hs.604479 xref: UniGene:Hs.655912 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043445 ! HEXA_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014163 name: ITPKB_human def: "Inositol-trisphosphate 3-kinase B gene" [UniProtKB:P27987] xref: EMBL:AJ242780 xref: EMBL:AL365444 xref: EMBL:BC015009 xref: EMBL:X57206 xref: EMBL:Y18024 xref: HGNC:HGNC:6179 xref: UniGene:Hs.528087 xref: UniGene:Hs.659396 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043425 ! IP3KB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014164 name: KCTD17_human def: "BTB/POZ domain-containing protein KCTD17 gene" [UniProtKB:Q8N5Z5] xref: EMBL:AK022304 xref: EMBL:AL022314 xref: EMBL:BC025403 xref: EMBL:BC031038 xref: HGNC:HGNC:25705 xref: UniGene:Hs.517597 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043424 ! KCD17_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014165 name: NCOA3_human def: "Nuclear receptor coactivator 3 gene" [UniProtKB:Q9Y6Q9] synonym: "AIB1" EXACT [UniProtKB:Q9Y6Q9] synonym: "RAC3" EXACT [UniProtKB:Q9Y6Q9] synonym: "TRAM1" EXACT [UniProtKB:Q9Y6Q9] xref: EMBL:AF010227 xref: EMBL:AF012108 xref: EMBL:AF016031 xref: EMBL:AF036892 xref: EMBL:AL034418 xref: HGNC:HGNC:7670 xref: UniGene:Hs.592142 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043428 ! NCOA3_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014166 name: PRNP_human def: "Major prion protein precursor gene" [UniProtKB:P04156] synonym: "PRIP" EXACT [UniProtKB:P04156] synonym: "PRP" EXACT [UniProtKB:P04156] xref: EMBL:AF030575 xref: EMBL:AF076976 xref: EMBL:AL133396 xref: EMBL:AY008282 xref: EMBL:BC012844 xref: EMBL:BC022532 xref: EMBL:D00015 xref: EMBL:DQ408531 xref: EMBL:M13667 xref: EMBL:M13899 xref: EMBL:M81929 xref: EMBL:M81930 xref: EMBL:S71208 xref: EMBL:S71210 xref: EMBL:S71212 xref: EMBL:S80732 xref: EMBL:S80743 xref: EMBL:U29185 xref: EMBL:X83416 xref: HGNC:HGNC:9449 xref: UniGene:Hs.472010 xref: UniGene:Hs.610285 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043436 ! PRIO_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014167 name: PSME2_human def: "Proteasome activator complex subunit 2 gene" [UniProtKB:Q9UL46] xref: EMBL:AF079558 xref: EMBL:BC004368 xref: EMBL:BC019885 xref: EMBL:BC072025 xref: EMBL:D45248 xref: HGNC:HGNC:9569 xref: UniGene:Hs.434081 xref: UniGene:Hs.512410 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043427 ! PSME2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014168 name: RASSF8_human def: "Ras association domain-containing protein 8 gene" [UniProtKB:Q8NHQ8] synonym: "C12orf2" EXACT [UniProtKB:Q8NHQ8] xref: EMBL:AB093206 xref: EMBL:AY665468 xref: EMBL:BC030021 xref: EMBL:U82396 xref: HGNC:HGNC:13232 xref: UniGene:Hs.696433 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043423 ! RASF8_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014169 name: RBM15B_human def: "Putative RNA-binding protein 15B gene" [UniProtKB:Q8NDT2] xref: EMBL:AL831838 xref: EMBL:AY545557 xref: EMBL:BC001367 xref: HGNC:HGNC:24303 xref: UniGene:Hs.118738 xref: UniGene:Hs.476291 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043450 ! RB15B_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014170 name: RERE_human def: "Arginine-glutamic acid dipeptide repeats protein gene" [UniProtKB:Q9P2R6] synonym: "ARG" EXACT [UniProtKB:Q9P2R6] synonym: "ARP" EXACT [UniProtKB:Q9P2R6] synonym: "ATN1L" EXACT [UniProtKB:Q9P2R6] synonym: "KIAA0458" EXACT [UniProtKB:Q9P2R6] xref: EMBL:AB007927 xref: EMBL:AB036737 xref: EMBL:AF016005 xref: EMBL:AF041096 xref: EMBL:AF041097 xref: EMBL:AF041098 xref: EMBL:AF041099 xref: EMBL:AF041100 xref: EMBL:AF041101 xref: EMBL:AF041102 xref: EMBL:AF041103 xref: EMBL:AF041104 xref: EMBL:AF118275 xref: EMBL:AL096855 xref: EMBL:AL356072 xref: EMBL:AL357713 xref: HGNC:HGNC:9965 xref: UniGene:Hs.463041 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043437 ! RERE_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014171 name: MRPL10_human def: "39S ribosomal protein L10, mitochondrial precursor gene" [UniProtKB:Q7Z7H8] xref: EMBL:AB051618 xref: EMBL:BC015904 xref: EMBL:BC052601 xref: HGNC:HGNC:14055 xref: UniGene:Hs.347535 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043446 ! RM10_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014172 name: RNF126_human def: "RING finger protein 126 gene" [UniProtKB:Q9BV68] xref: EMBL:AK000559 xref: EMBL:BC001442 xref: EMBL:BC025374 xref: HGNC:HGNC:21151 xref: UniGene:Hs.69554 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043418 ! RN126_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014173 name: RNF5_human def: "E3 ubiquitin-protein ligase RNF5 gene" [UniProtKB:Q99942] synonym: "G16" EXACT [UniProtKB:Q99942] synonym: "NG2" EXACT [UniProtKB:Q99942] synonym: "RMA1" EXACT [UniProtKB:Q99942] xref: EMBL:AB056869 xref: EMBL:AJ243936 xref: EMBL:AL662830 xref: EMBL:AL662884 xref: EMBL:AL845464 xref: EMBL:BC004155 xref: EMBL:BC111392 xref: EMBL:BC119741 xref: EMBL:BC119742 xref: EMBL:BC127651 xref: EMBL:BC127652 xref: EMBL:BT007105 xref: EMBL:U89336 xref: HGNC:HGNC:10068 xref: UniGene:Hs.534342 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043430 ! RNF5_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014174 name: SNRPB_human def: "Small nuclear ribonucleoprotein-associated proteins B and B' gene" [UniProtKB:P14678] synonym: "COD" EXACT [UniProtKB:P14678] synonym: "SNRPB1" EXACT [UniProtKB:P14678] xref: EMBL:AF134822 xref: EMBL:AF134823 xref: EMBL:AF134824 xref: EMBL:AF134825 xref: EMBL:AL049650 xref: EMBL:M34081 xref: EMBL:M34082 xref: EMBL:X15893 xref: EMBL:X17567 xref: EMBL:X17568 xref: EMBL:X52979 xref: HGNC:HGNC:11153 xref: UniGene:Hs.83753 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043440 ! RSMB_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014175 name: MRPS9_human def: "28S ribosomal protein S9, mitochondrial precursor gene" [UniProtKB:P82933] synonym: "RPMS9" EXACT [UniProtKB:P82933] xref: EMBL:BF034318 xref: HGNC:HGNC:14501 xref: UniGene:Hs.590900 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043448 ! RT09_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014176 name: SNRPF_human def: "Small nuclear ribonucleoprotein F gene" [UniProtKB:P62306] synonym: "PBSCF" EXACT [UniProtKB:P62306] xref: EMBL:BC002505 xref: EMBL:BC063397 xref: EMBL:BC128452 xref: EMBL:BC128453 xref: EMBL:CR456751 xref: EMBL:X85372 xref: HGNC:HGNC:11162 xref: UniGene:Hs.105465 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043438 ! RUXF_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014177 name: SERF2_human def: "Small EDRK-rich factor 2 gene" [UniProtKB:P84101] synonym: "FAM2C" EXACT [UniProtKB:P84101] xref: EMBL:AF073298 xref: EMBL:AF320073 xref: EMBL:BC009869 xref: EMBL:BC015491 xref: HGNC:HGNC:10757 xref: UniGene:Hs.424126 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043420 ! SERF2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014178 name: TNNT1_human def: "Troponin T, slow skeletal muscle gene" [UniProtKB:P13805] synonym: "TNT" EXACT [UniProtKB:P13805] xref: EMBL:AJ011712 xref: EMBL:AJ011713 xref: EMBL:BC010963 xref: EMBL:BC022086 xref: EMBL:BC034143 xref: EMBL:M19308 xref: EMBL:M19309 xref: EMBL:S66057 xref: EMBL:S66170 xref: EMBL:S69208 xref: EMBL:S69209 xref: HGNC:HGNC:11948 xref: UniGene:Hs.631558 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043421 ! TNNT1_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014179 name: TRIM39_human def: "Tripartite motif-containing protein 39 gene" [UniProtKB:Q9HCM9] synonym: "RNF23" EXACT [UniProtKB:Q9HCM9] synonym: "TFP" EXACT [UniProtKB:Q9HCM9] xref: EMBL:AB046381 xref: EMBL:AB110937 xref: EMBL:BC007661 xref: EMBL:BC034985 xref: EMBL:BT007370 xref: HGNC:HGNC:10065 xref: UniGene:Hs.413493 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043417 ! TRI39_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014180 name: TRIM9_human def: "Tripartite motif-containing protein 9 gene" [UniProtKB:Q9C026] synonym: "KIAA0282" EXACT [UniProtKB:Q9C026] synonym: "RNF91" EXACT [UniProtKB:Q9C026] xref: EMBL:AF220036 xref: EMBL:AF220037 xref: EMBL:AF220038 xref: EMBL:AK055388 xref: EMBL:BC013414 xref: EMBL:BC063872 xref: EMBL:D87458 xref: HGNC:HGNC:16288 xref: UniGene:Hs.654750 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043426 ! TRIM9_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014181 name: VCL_human def: "Vinculin gene" [UniProtKB:P18206] xref: EMBL:AL596247 xref: EMBL:AL731576 xref: EMBL:BC039174 xref: EMBL:BX537994 xref: EMBL:L04933 xref: EMBL:M33308 xref: EMBL:S87175 xref: EMBL:S87178 xref: EMBL:S87180 xref: EMBL:S87218 xref: EMBL:S87223 xref: HGNC:HGNC:12665 xref: UniGene:Hs.699180 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043439 ! VINC_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014182 name: XRN2_human def: "5'-3' exoribonuclease 2 gene" [UniProtKB:Q9H0D6] xref: EMBL:AF064257 xref: EMBL:AF152169 xref: EMBL:AK000084 xref: EMBL:AL117332 xref: EMBL:AL136841 xref: EMBL:AL158013 xref: EMBL:AY382900 xref: EMBL:BC006417 xref: HGNC:HGNC:12836 xref: UniGene:Hs.255932 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043429 ! XRN2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:G0014183 name: FLJ10324_human def: "Putative uncharacterized protein FLJ10324 gene" [UniProtKB:Q75LH2] xref: EMBL:AC092610 xref: UniGene:Hs.667336 is_a: CCO:U0000008 ! cell cycle gene relationship: codes_for CCO:B0043449 ! Q75LH2_HUMAN relationship: has_source CCO:T0000004 ! Homo sapiens organism [Term] id: CCO:I0005721 name: cdca3-traf2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752470 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002076 ! CDCA3_HUMAN relationship: has_participant CCO:B0005170 ! TRAF2_HUMAN [Term] id: CCO:I0005722 name: lmo2-mapre2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752503 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001811 ! MARE2_HUMAN relationship: has_participant CCO:B0005171 ! RBTN2_HUMAN [Term] id: CCO:I0005723 name: atf4-gps2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752611 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001746 ! GPS2_HUMAN relationship: has_participant CCO:B0005172 ! Q96AQ3_HUMAN [Term] id: CCO:I0005724 name: pard6a-prkci physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752629 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0005725 name: tlk1-tlk1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752671 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002220 ! TLK1_HUMAN [Term] id: CCO:I0005726 name: qprt-sufu physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752686 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005174 ! NADC_HUMAN [Term] id: CCO:I0005728 name: ccnk-tsc22d4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752779 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:I0005729 name: dctn2-gadd45a physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752782 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001552 ! GA45A_HUMAN relationship: has_participant CCO:B0005177 ! DCTN2_HUMAN [Term] id: CCO:I0005730 name: lzts2-rbpms physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752833 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN relationship: has_participant CCO:B0005178 ! RBPMS_HUMAN [Term] id: CCO:I0005731 name: c8orf32-nme1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752854 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001524 ! NDKA_HUMAN relationship: has_participant CCO:B0005179 ! CH032_HUMAN [Term] id: CCO:I0005732 name: dazap2-sept2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752869 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001800 ! SEPT2_HUMAN relationship: has_participant CCO:B0005180 ! DAZP2_HUMAN [Term] id: CCO:I0005733 name: appl1-dip13b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752875 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001980 ! DP13B_HUMAN relationship: has_participant CCO:B0002219 ! DP13A_HUMAN [Term] id: CCO:I0005734 name: ccnh-sssca1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752911 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0001652 ! CCNH_HUMAN [Term] id: CCO:I0005736 name: c14orf32-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752968 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0041276 ! MISSL_HUMAN [Term] id: CCO:I0005737 name: pin1-traf2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752986 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005170 ! TRAF2_HUMAN [Term] id: CCO:I0005738 name: fhit-fhit physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753016 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001636 ! FHIT_HUMAN [Term] id: CCO:I0005739 name: c18orf24-pldn physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753067 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002032 ! SKA1_HUMAN relationship: has_participant CCO:B0005183 ! PLDN_HUMAN [Term] id: CCO:I0005741 name: mageb18-tp53 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753139 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005185 ! MAGBI_HUMAN [Term] id: CCO:I0005742 name: c18orf25-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753160 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005186 ! CR025_HUMAN [Term] id: CCO:I0005743 name: mad1l1-tex11 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753268 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0005187 ! TEX11_HUMAN [Term] id: CCO:I0005744 name: ddit3-dhrs10 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753277 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001594 ! DDIT3_HUMAN relationship: has_participant CCO:B0026267 ! DHB14_HUMAN [Term] id: CCO:I0005745 name: pin1-tsc22d4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753286 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:I0005746 name: krt18-q9bvr6 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753352 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0005189 ! Q9BVR6_HUMAN [Term] id: CCO:I0005748 name: satb1-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753613 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005191 ! SATB1_HUMAN [Term] id: CCO:I0005749 name: pin1-rai1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753652 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005192 ! RAI1_HUMAN [Term] id: CCO:I0005750 name: lzts2-pak7 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753757 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN relationship: has_participant CCO:B0005193 ! Q8TB93_HUMAN [Term] id: CCO:I0005752 name: dach1-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753847 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005195 ! DACH1_HUMAN [Term] id: CCO:I0005753 name: myo15b-sssca1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753862 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0005196 ! Q8N374_HUMAN [Term] id: CCO:I0005754 name: ap2b1-mlh1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753892 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001601 ! MLH1_HUMAN relationship: has_participant CCO:B0005197 ! AP2B1_HUMAN [Term] id: CCO:I0005755 name: nudcd3-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753934 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005198 ! NUDC3_HUMAN [Term] id: CCO:I0005756 name: hspa2-hspbp1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753937 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005199 ! HPBP1_HUMAN [Term] id: CCO:I0005757 name: gga2-pin1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753949 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005200 ! GGA2_HUMAN [Term] id: CCO:I0005758 name: glis3-sufu physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754015 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005201 ! GLIS3_HUMAN [Term] id: CCO:I0005760 name: cutc-pim2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754093 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002185 ! PIM2_HUMAN relationship: has_participant CCO:B0005203 ! Q96BX3_HUMAN [Term] id: CCO:I0005761 name: mlh1-trim29 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754114 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001601 ! MLH1_HUMAN relationship: has_participant CCO:B0005204 ! TRI29_HUMAN [Term] id: CCO:I0005763 name: il1f5-mcm6 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754186 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0005205 ! IL1F5_HUMAN [Term] id: CCO:I0005764 name: kntc2-pldn physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754198 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0005183 ! PLDN_HUMAN [Term] id: CCO:I0005765 name: nme1-nme4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754228 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001524 ! NDKA_HUMAN relationship: has_participant CCO:B0005206 ! NDKM_HUMAN [Term] id: CCO:I0005766 name: krt15-krt18 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754231 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0005207 ! K1C15_HUMAN [Term] id: CCO:I0005767 name: mgc5356-sssca1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754267 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0005208 ! CT195_HUMAN [Term] id: CCO:I0005768 name: fancg-gabpb2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754297 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001370 ! FANCG_HUMAN relationship: has_participant CCO:B0040683 ! GABP1_HUMAN [Term] id: CCO:I0005769 name: cdkn1a-tex11 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754360 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0005187 ! TEX11_HUMAN [Term] id: CCO:I0005770 name: ccnk-ushbp1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754390 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005210 ! USBP1_HUMAN [Term] id: CCO:I0005773 name: ube2i-znfn1a1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754453 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005213 ! IKZF1_HUMAN [Term] id: CCO:I0005774 name: lzts2-znf581 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754540 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN relationship: has_participant CCO:B0005214 ! ZN581_HUMAN [Term] id: CCO:I0005775 name: ccnk-efemp2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754681 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005215 ! FBLN4_HUMAN [Term] id: CCO:I0005776 name: ripk2-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754693 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005216 ! RIPK2_HUMAN [Term] id: CCO:I0005777 name: ccnk-kcnrg physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754696 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005217 ! KCNRG_HUMAN [Term] id: CCO:I0005778 name: pin1-zimp7 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754708 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005218 ! ZMIZ2_HUMAN [Term] id: CCO:I0005779 name: cdk4-cdkn2d physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754729 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001675 ! CDN2D_HUMAN [Term] id: CCO:I0005780 name: sept1-sept6 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754768 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001775 ! SEPT6_HUMAN relationship: has_participant CCO:B0002011 ! SEPT1_HUMAN [Term] id: CCO:I0005781 name: ccnk-fkbp6 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754822 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005219 ! FKBP6_HUMAN [Term] id: CCO:I0005782 name: ccnk-stx11 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754849 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005220 ! STX11_HUMAN [Term] id: CCO:I0005783 name: hist1h3a-nasp physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754897 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001626 ! NASP_HUMAN relationship: has_participant CCO:B0005221 ! H31_HUMAN [Term] id: CCO:I0005784 name: ccnk-rfxdc1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754903 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0031197 ! RFXD1_HUMAN [Term] id: CCO:I0005785 name: mcm7-rbm8a physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754909 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0005223 ! RBM8A_HUMAN [Term] id: CCO:I0005786 name: cdk5r1-tsc22d4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754939 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001802 ! CD5R1_HUMAN relationship: has_participant CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:I0005788 name: pdlim7-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755017 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005224 ! PDLI7_HUMAN [Term] id: CCO:I0005789 name: hrasls3-ubqln1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755041 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001666 ! HRSL3_HUMAN relationship: has_participant CCO:B0005181 ! UBQL1_HUMAN [Term] id: CCO:I0005791 name: rhebl1-txnl4a physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755179 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001702 ! TXN4A_HUMAN relationship: has_participant CCO:B0040684 ! REBL1_HUMAN [Term] id: CCO:I0005792 name: ndp52-shc1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755236 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0026268 ! CACO2_HUMAN [Term] id: CCO:I0005793 name: rad54b-znf580 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755269 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002260 ! RA54B_HUMAN relationship: has_participant CCO:B0005228 ! ZN580_HUMAN [Term] id: CCO:I0005795 name: ube2i-znf646 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755329 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005230 ! Q8IVD8_HUMAN [Term] id: CCO:I0005796 name: fancg-zbed1x physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755359 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001370 ! FANCG_HUMAN relationship: has_participant CCO:B0005231 ! ZBED1_HUMAN [Term] id: CCO:I0005798 name: ccnk-rbpms physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755404 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005178 ! RBPMS_HUMAN [Term] id: CCO:I0005799 name: ccnh-psma1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755419 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001652 ! CCNH_HUMAN relationship: has_participant CCO:B0005233 ! PSA1_HUMAN [Term] id: CCO:I0005801 name: cdc23-rad54b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755449 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0002260 ! RA54B_HUMAN [Term] id: CCO:I0005802 name: mad2l1-tsc22d4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755488 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:I0005803 name: mad1l1-nono physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755521 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0005234 ! NONO_HUMAN [Term] id: CCO:I0005804 name: hnrpk-rbm7 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755539 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002255 ! RBM7_HUMAN relationship: has_participant CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:I0005805 name: aff4-siah1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755596 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001946 ! SIAH1_HUMAN relationship: has_participant CCO:B0005236 ! Q8TAX5_HUMAN [Term] id: CCO:I0005806 name: cdc23-rbpms physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755605 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0005178 ! RBPMS_HUMAN [Term] id: CCO:I0005807 name: dip13b-rab22a physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755644 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001980 ! DP13B_HUMAN relationship: has_participant CCO:B0005237 ! RB22A_HUMAN [Term] id: CCO:I0005808 name: ube2i-znfn1a3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755677 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005238 ! Q8N574_HUMAN [Term] id: CCO:I0005810 name: mdfi-pin1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755749 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005232 ! MDFI_HUMAN [Term] id: CCO:I0005811 name: atrip-ribc2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755758 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002009 ! ATRIP_HUMAN relationship: has_participant CCO:B0005240 ! RIBC2_HUMAN [Term] id: CCO:I0005812 name: appl1-traf2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755770 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002219 ! DP13A_HUMAN relationship: has_participant CCO:B0005170 ! TRAF2_HUMAN [Term] id: CCO:I0005813 name: gorasp2-rad54b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755800 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002260 ! RA54B_HUMAN relationship: has_participant CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:I0005815 name: il16-sssca1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755926 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0005242 ! Q8IUU6_HUMAN [Term] id: CCO:I0005816 name: lzts2-trim29 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755938 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN relationship: has_participant CCO:B0005204 ! TRI29_HUMAN [Term] id: CCO:I0005817 name: psma1-rad54b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755941 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002260 ! RA54B_HUMAN relationship: has_participant CCO:B0005233 ! PSA1_HUMAN [Term] id: CCO:I0005818 name: ard1-cdc25a physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755974 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001576 ! MPIP1_HUMAN relationship: has_participant CCO:B0005243 ! ARD1A_HUMAN [Term] id: CCO:I0005819 name: magea11-mlf1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755980 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001684 ! MLF1_HUMAN relationship: has_participant CCO:B0005212 ! MAGAB_HUMAN [Term] id: CCO:I0005820 name: ccnk-cep76 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755986 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005244 ! CEP76_HUMAN [Term] id: CCO:I0005821 name: c10orf3-pom121 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756040 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001837 ! CEP55_HUMAN relationship: has_participant CCO:B0005245 ! Q96HA1_HUMAN [Term] id: CCO:I0005822 name: lmo2-mapre3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756190 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002238 ! MARE3_HUMAN relationship: has_participant CCO:B0005171 ! RBTN2_HUMAN [Term] id: CCO:I0005823 name: nme1-polr1c physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756196 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001524 ! NDKA_HUMAN relationship: has_participant CCO:B0005246 ! RPAC1_HUMAN [Term] id: CCO:I0005825 name: sept2-sept6 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756268 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001775 ! SEPT6_HUMAN relationship: has_participant CCO:B0001800 ! SEPT2_HUMAN [Term] id: CCO:I0005826 name: rcn3-sufu physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756313 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005248 ! RCN3_HUMAN [Term] id: CCO:I0005827 name: mcm6-psma1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756361 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0005233 ! PSA1_HUMAN [Term] id: CCO:I0005828 name: dlg7-traf2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756439 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001807 ! DLG7_HUMAN relationship: has_participant CCO:B0005170 ! TRAF2_HUMAN [Term] id: CCO:I0005829 name: dlg7-trim37 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756466 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001807 ! DLG7_HUMAN relationship: has_participant CCO:B0005249 ! TRI37_HUMAN [Term] id: CCO:I0005831 name: sssca1-sssca1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756523 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001405 ! SSA27_HUMAN [Term] id: CCO:I0005832 name: gorasp2-nme1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756532 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001524 ! NDKA_HUMAN relationship: has_participant CCO:B0005241 ! GORS2_HUMAN [Term] id: CCO:I0005833 name: mcm6-scnm1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756568 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0005251 ! SCNM1_HUMAN [Term] id: CCO:I0005834 name: mlh1-zc3h11a physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756601 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001601 ! MLH1_HUMAN relationship: has_participant CCO:B0005252 ! ZC11A_HUMAN [Term] id: CCO:I0005835 name: myo15b-rad54b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756625 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002260 ! RA54B_HUMAN relationship: has_participant CCO:B0005196 ! Q8N374_HUMAN [Term] id: CCO:I0005836 name: cct3-sssca1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756637 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0005253 ! TCPG_HUMAN [Term] id: CCO:I0005838 name: krt18-ldoc1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756694 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0005202 ! LDOC1_HUMAN [Term] id: CCO:I0005839 name: exoc8-krt18 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756712 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0005255 ! EXOC8_HUMAN [Term] id: CCO:I0005840 name: rbm7-rbmx physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756715 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002255 ! RBM7_HUMAN relationship: has_participant CCO:B0005256 ! HNRPG_HUMAN [Term] id: CCO:I0005841 name: fancg-samd3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756754 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001370 ! FANCG_HUMAN relationship: has_participant CCO:B0005257 ! SAMD3_HUMAN [Term] id: CCO:I0005842 name: ccnd3-dtnbp1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756760 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0005258 ! DTBP1_HUMAN [Term] id: CCO:I0005843 name: ccnd2-cdkn1a physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756799 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001573 ! CCND2_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0005844 name: c6orf55-sssca1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756895 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0005259 ! VTA1_HUMAN [Term] id: CCO:I0005845 name: ccnd3-efemp2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756922 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0005215 ! FBLN4_HUMAN [Term] id: CCO:I0005846 name: mapre2-nif3l1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757006 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001811 ! MARE2_HUMAN relationship: has_participant CCO:B0005260 ! NIF3L_HUMAN [Term] id: CCO:I0005848 name: cdc23-tsc22d4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757051 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:I0005849 name: c10orf119-ddit3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757285 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001594 ! DDIT3_HUMAN relationship: has_participant CCO:B0005262 ! CJ119_HUMAN [Term] id: CCO:I0005850 name: mltk-znf567 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757294 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002178 ! MLTK_HUMAN relationship: has_participant CCO:B0005263 ! ZN567_HUMAN [Term] id: CCO:I0005851 name: phc1-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757324 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005264 ! PHC1_HUMAN [Term] id: CCO:I0005852 name: dyrk2-rad54b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757351 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002260 ! RA54B_HUMAN relationship: has_participant CCO:B0005265 ! DYRK2_HUMAN [Term] id: CCO:I0005854 name: frmd6-mlh1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757414 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001601 ! MLH1_HUMAN relationship: has_participant CCO:B0005267 ! FRMD6_HUMAN [Term] id: CCO:I0005855 name: dkfzp564e2182-tlk1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757417 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002220 ! TLK1_HUMAN relationship: has_participant CCO:B0005268 ! ASF1A_HUMAN [Term] id: CCO:I0005856 name: sufu-znf446 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757429 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005269 ! Q96AF5_HUMAN [Term] id: CCO:I0005857 name: chmp4b-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757456 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005270 ! CHM4B_HUMAN [Term] id: CCO:I0005858 name: mbip-mcm7 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757477 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0005271 ! MBIP1_HUMAN [Term] id: CCO:I0005859 name: mapre2-mapre2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757483 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001811 ! MARE2_HUMAN [Term] id: CCO:I0005860 name: e2f6-tfdp1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757528 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001429 ! E2F6_HUMAN relationship: has_participant CCO:B0001776 ! TFDP1_HUMAN [Term] id: CCO:I0005861 name: csnk1e-rad54b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757558 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002260 ! RA54B_HUMAN relationship: has_participant CCO:B0005272 ! KC1E_HUMAN [Term] id: CCO:I0005862 name: dvl2-tp53 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757585 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005211 ! DVL2_HUMAN [Term] id: CCO:I0005863 name: sept1-tollip physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757594 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002011 ! SEPT1_HUMAN relationship: has_participant CCO:B0005273 ! TOLIP_HUMAN [Term] id: CCO:I0005864 name: lzts2-pepp2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757645 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN relationship: has_participant CCO:B0005274 ! RHXF2_HUMAN [Term] id: CCO:I0005865 name: khdrbs3-rbm7 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757663 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002255 ! RBM7_HUMAN relationship: has_participant CCO:B0005275 ! KHDR3_HUMAN [Term] id: CCO:I0005866 name: mgc13138-sufu physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757699 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005276 ! ZN764_HUMAN [Term] id: CCO:I0005867 name: cks2-tsc22d4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757702 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001586 ! CKS2_HUMAN relationship: has_participant CCO:B0005176 ! T22D4_HUMAN [Term] id: CCO:I0005870 name: psmd2-ublcp1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757798 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001745 ! PSMD2_HUMAN relationship: has_participant CCO:B0005278 ! UBCP1_HUMAN [Term] id: CCO:I0005871 name: cdkn2d-tbc1d17 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757825 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001675 ! CDN2D_HUMAN relationship: has_participant CCO:B0005279 ! TBC17_HUMAN [Term] id: CCO:I0005873 name: hgs-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757864 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005280 ! HGS_HUMAN [Term] id: CCO:I0005874 name: hnrpc-pin1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757900 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:I0005875 name: rad54b-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757909 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0002260 ! RA54B_HUMAN [Term] id: CCO:I0005876 name: ube2i-zbed1x physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757915 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005231 ! ZBED1_HUMAN [Term] id: CCO:I0005877 name: mid1ip1-sufu physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757921 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005281 ! M1IP1_HUMAN [Term] id: CCO:I0005878 name: lzts2-traf2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758002 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN relationship: has_participant CCO:B0005170 ! TRAF2_HUMAN [Term] id: CCO:I0005879 name: mgc3162-sssca1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758122 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0005282 ! NOC4L_HUMAN [Term] id: CCO:I0005880 name: c10orf3-tsg101 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758152 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001837 ! CEP55_HUMAN relationship: has_participant CCO:B0005283 ! TS101_HUMAN [Term] id: CCO:I0005881 name: pin1-rbpms physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758248 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005178 ! RBPMS_HUMAN [Term] id: CCO:I0005882 name: rad54b-ribc2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758257 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002260 ! RA54B_HUMAN relationship: has_participant CCO:B0005240 ! RIBC2_HUMAN [Term] id: CCO:I0005883 name: ing5-mcm6 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758263 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0005284 ! ING5_HUMAN [Term] id: CCO:I0005884 name: ccnk-pepp2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758335 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005274 ! RHXF2_HUMAN [Term] id: CCO:I0005885 name: c6orf55-cdk4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758428 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0005259 ! VTA1_HUMAN [Term] id: CCO:I0005886 name: hist2h3c-nasp physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758497 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001626 ! NASP_HUMAN relationship: has_participant CCO:B0005285 ! H32_HUMAN [Term] id: CCO:I0005887 name: ccnd2-cdkn1b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758509 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001573 ! CCND2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0005888 name: c14orf48-c18orf24 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758521 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002032 ! SKA1_HUMAN relationship: has_participant CCO:B0005286 ! CN048_HUMAN [Term] id: CCO:I0005890 name: arih2-bub1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758548 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001395 ! BUB1_HUMAN relationship: has_participant CCO:B0005288 ! ARI2_HUMAN [Term] id: CCO:I0005891 name: pin1-rbbp8 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758605 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005289 ! Q8NHQ3_HUMAN [Term] id: CCO:I0005892 name: mapre2-mapre3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758671 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001811 ! MARE2_HUMAN relationship: has_participant CCO:B0002238 ! MARE3_HUMAN [Term] id: CCO:I0005894 name: c1orf117-mad1l1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758800 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0005290 ! F131C_HUMAN [Term] id: CCO:I0005895 name: cct5-sssca1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758803 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0005291 ! TCPE_HUMAN [Term] id: CCO:I0005896 name: ddit3-spop physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758812 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001594 ! DDIT3_HUMAN relationship: has_participant CCO:B0005292 ! SPOP_HUMAN [Term] id: CCO:I0005897 name: cdkn2b-magea11 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758866 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001616 ! CDN2B_HUMAN relationship: has_participant CCO:B0005212 ! MAGAB_HUMAN [Term] id: CCO:I0005898 name: cdkn1b-traf2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758869 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005170 ! TRAF2_HUMAN [Term] id: CCO:I0005899 name: kntc2-ushbp1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758875 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0005210 ! USBP1_HUMAN [Term] id: CCO:I0005900 name: ccnk-krtap4_12 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758917 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005293 ! KR412_HUMAN [Term] id: CCO:I0005901 name: trim29-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758929 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005204 ! TRI29_HUMAN [Term] id: CCO:I0005902 name: hgs-krt18 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758998 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0005280 ! HGS_HUMAN [Term] id: CCO:I0005903 name: krt18-nme7 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759004 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0005294 ! NDK7_HUMAN [Term] id: CCO:I0005904 name: ccnk-pctk3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759022 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005295 ! PCTK3_HUMAN [Term] id: CCO:I0005905 name: mad1l1-trim29 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759037 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0005204 ! TRI29_HUMAN [Term] id: CCO:I0005906 name: hmg20a-rbm7 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759064 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002255 ! RBM7_HUMAN relationship: has_participant CCO:B0005296 ! HM20A_HUMAN [Term] id: CCO:I0005907 name: sufu-znf263 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759070 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005297 ! ZN263_HUMAN [Term] id: CCO:I0005908 name: prkar1a-pycard physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759079 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002228 ! ASC_HUMAN relationship: has_participant CCO:B0005298 ! KAP0_HUMAN [Term] id: CCO:I0005909 name: fancg-ushbp1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759091 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001370 ! FANCG_HUMAN relationship: has_participant CCO:B0005210 ! USBP1_HUMAN [Term] id: CCO:I0005910 name: ccnk-hmg20a physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759097 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005296 ! HM20A_HUMAN [Term] id: CCO:I0005911 name: amotl2-kntc2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759109 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0005299 ! AMOL2_HUMAN [Term] id: CCO:I0005912 name: amotl2-mad1l1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759142 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0005299 ! AMOL2_HUMAN [Term] id: CCO:I0005913 name: rad54b-rad54b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759217 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002260 ! RA54B_HUMAN [Term] id: CCO:I0005914 name: gps2-tak1l physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759232 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001746 ! GPS2_HUMAN relationship: has_participant CCO:B0005300 ! TAK1L_HUMAN [Term] id: CCO:I0005915 name: nono-pin1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759286 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005234 ! NONO_HUMAN [Term] id: CCO:I0005916 name: ccnd3-maf1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759310 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0005301 ! MAF1_HUMAN [Term] id: CCO:I0005917 name: cdca3-ctdsp1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759484 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002076 ! CDCA3_HUMAN relationship: has_participant CCO:B0005302 ! CTDS1_HUMAN [Term] id: CCO:I0005918 name: mcm6-mllt3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759490 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0005303 ! Q8IVB0_HUMAN [Term] id: CCO:I0005920 name: hnrpc-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759535 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005239 ! HNRPC_HUMAN [Term] id: CCO:I0005921 name: magea11-wtap physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759595 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001798 ! FL2D_HUMAN relationship: has_participant CCO:B0005212 ! MAGAB_HUMAN [Term] id: CCO:I0005923 name: lnx-rad54b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759655 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002260 ! RA54B_HUMAN relationship: has_participant CCO:B0005305 ! LNX1_HUMAN [Term] id: CCO:I0005924 name: pbk-trim37 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759697 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002045 ! TOPK_HUMAN relationship: has_participant CCO:B0005249 ! TRI37_HUMAN [Term] id: CCO:I0005927 name: mad1l1-q9bvr6 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759859 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0005189 ! Q9BVR6_HUMAN [Term] id: CCO:I0005928 name: ube2i-znf451 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759886 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005308 ! ZN451_HUMAN [Term] id: CCO:I0005929 name: hnrpk-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759901 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:I0005931 name: mlh1-ubox5 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759928 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001601 ! MLH1_HUMAN relationship: has_participant CCO:B0005309 ! RNF37_HUMAN [Term] id: CCO:I0005932 name: ewsr1-suv39h2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759964 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002139 ! SUV92_HUMAN relationship: has_participant CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:I0005935 name: sept1-sept1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760054 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002011 ! SEPT1_HUMAN [Term] id: CCO:I0005936 name: pex26-sufu physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760081 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005312 ! PEX26_HUMAN [Term] id: CCO:I0005937 name: krt15-mad2l1bp physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760114 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN relationship: has_participant CCO:B0005207 ! K1C15_HUMAN [Term] id: CCO:I0005939 name: psmc1-psmd2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760192 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001745 ! PSMD2_HUMAN relationship: has_participant CCO:B0005314 ! PRS4_HUMAN [Term] id: CCO:I0005940 name: pard6a-prkcz physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760198 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005315 ! KPCZ_HUMAN [Term] id: CCO:I0005941 name: nme1-nme3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760207 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001524 ! NDKA_HUMAN relationship: has_participant CCO:B0005316 ! NDK3_HUMAN [Term] id: CCO:I0005942 name: cbx5-suv39h1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760225 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:I0005944 name: ccnd3-cdkn1b physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760261 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0005945 name: khdrbs3-siah1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760273 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001946 ! SIAH1_HUMAN relationship: has_participant CCO:B0005275 ! KHDR3_HUMAN [Term] id: CCO:I0005946 name: cdk4-cdkn2b-1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760282 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001616 ! CDN2B_HUMAN [Term] id: CCO:I0005947 name: e2f6-tfdp2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760288 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001429 ! E2F6_HUMAN relationship: has_participant CCO:B0001777 ! TFDP2_HUMAN [Term] id: CCO:I0005949 name: mcm2-mcm6 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760342 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:I0005951 name: batf-ddit3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760366 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001594 ! DDIT3_HUMAN relationship: has_participant CCO:B0005320 ! BATF_HUMAN [Term] id: CCO:I0005952 name: pias2-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760369 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005321 ! PIAS2_HUMAN [Term] id: CCO:I0005953 name: mad1l1-mad1l1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760381 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN [Term] id: CCO:I0005954 name: smad4-ube2i physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760393 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005322 ! SMAD4_HUMAN [Term] id: CCO:I0005955 name: nme1-nme1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760399 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001524 ! NDKA_HUMAN [Term] id: CCO:I0005956 name: ccnd3-cdkn1a physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760414 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0005957 name: ccnd3-cdk4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760426 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001574 ! CCND3_HUMAN [Term] id: CCO:I0005958 name: mcm6-mcm6-1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760429 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:I0005959 name: fanca-fancg physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760435 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001370 ! FANCG_HUMAN relationship: has_participant CCO:B0005323 ! FANCA_HUMAN [Term] id: CCO:I0005960 name: mad1l1-mad2l1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760453 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN [Term] id: CCO:I0005961 name: cebpg-ddit3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760462 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001594 ! DDIT3_HUMAN relationship: has_participant CCO:B0005324 ! CEBPG_HUMAN [Term] id: CCO:I0005962 name: cdkn1a-pcna physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760468 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001513 ! PCNA_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0005963 name: pin2_trf1-eb1-1 physical interaction comment: Interaction between human Pin2/TRF1 and EB1 detected by coIP xref: IntAct:EBI-1004274 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0001812 ! MARE1_HUMAN [Term] id: CCO:I0005964 name: smc1-mcm7-1 physical interaction comment: Interaction between human Smc1 and MCM7 detected by TAP xref: IntAct:EBI-1004658 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0005965 name: smc1-mcm7-3 physical interaction comment: Interaction between human Smc1 and MCM7 detected by coIP xref: IntAct:EBI-1004708 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0005966 name: mcm7-smc1-2 physical interaction comment: Interaction between human MCM7 and Smc1 detected by coIP xref: IntAct:EBI-1004723 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0005967 name: mcm6-smc1-1 physical interaction comment: Interaction between human MCM6 and Smc1 detected by coIP xref: IntAct:EBI-1004729 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0005968 name: mcm6-mcm7-1 physical interaction comment: Interaction between human MCM6 and MCM7 detected by coIP xref: IntAct:EBI-1004735 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:I0005972 name: egf-egfr-2 direct interaction comment: Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. xref: IntAct:EBI-1034411 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001470 ! EGF_HUMAN [Term] id: CCO:I0005973 name: bmp7-nog-1 direct interaction comment: Crystal structure of bone morphogenetic protein-7 (bmp-7) in complex with the secreted antagonist noggin xref: IntAct:EBI-1035219 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001531 ! BMP7_HUMAN relationship: has_participant CCO:B0005328 ! NOGG_HUMAN [Term] id: CCO:I0005974 name: ube1c-ube2m-1 direct interaction comment: Structural basis for recruitment of ubc12 by an e2-binding domain in nedd8's e1 xref: IntAct:EBI-1041674 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001989 ! UBA3_HUMAN relationship: has_participant CCO:B0005329 ! UBC12_HUMAN [Term] id: CCO:I0005976 name: nedd8-tp53-1 neddylation comment: Neddylation of p53 xref: IntAct:EBI-1171060 is_a: CCO:Y0000036 ! neddylation reaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001758 ! ULA1_HUMAN relationship: has_participant CCO:B0001989 ! UBA3_HUMAN relationship: has_participant CCO:B0005329 ! UBC12_HUMAN relationship: has_participant CCO:B0005331 ! NEDD8_HUMAN relationship: has_participant CCO:B0005332 ! FBX11_HUMAN [Term] id: CCO:I0005977 name: hspb9-ctcf physical interaction comment: HSPB9 interacted with CTCF in a yeast two hybrid assay xref: IntAct:EBI-1176478 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001630 ! CTCF_HUMAN relationship: has_participant CCO:B0005333 ! HSPB9_HUMAN [Term] id: CCO:I0005978 name: e6-e6ap-tp53 physical interaction xref: IntAct:EBI-1186940 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005334 ! UBE3A_HUMAN [Term] id: CCO:I0005979 name: e6ap-tp53 physical interaction xref: IntAct:EBI-1186952 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005334 ! UBE3A_HUMAN [Term] id: CCO:I0005980 name: snip1-myc-2 physical interaction comment: SNIP1 coimmunoprecipitates c-Myc in HEK293 cell lysate xref: IntAct:EBI-1189163 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:I0005981 name: myc-snip1-1 physical interaction comment: SNIP1 coimmunoprecipitates with c-Myc in HEK293 cell lysate xref: IntAct:EBI-1189169 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:I0005982 name: max-myc-4 physical interaction comment: Max coimmunoprecipitates c-Myc in HEK293 cell lysate xref: IntAct:EBI-1189183 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005336 ! MAX_HUMAN [Term] id: CCO:I0005983 name: snip1-myc-4 physical interaction comment: SNIP1 coimmunoprecipitates c-Myc in HEK293 cell lysate xref: IntAct:EBI-1189347 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:I0005984 name: cdn1b-cdk2-1 physical interaction comment: Interaction between CDN1B (p27), Cyclin E1 and CDK2 identified by coimmunoprecipitation xref: IntAct:EBI-1201114 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0005985 name: cdn1b-cdk2-2 physical interaction comment: Interaction between CDN1B (p27), Cyclin E1 and CDK2 identified by coimmunoprecipitation xref: IntAct:EBI-1201133 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0005986 name: pcna-pold1-1 physical interaction comment: Interaction between PCNA, POLD1 and CHAF1A identified by coimmunoprecipitation xref: IntAct:EBI-1202904 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001513 ! PCNA_HUMAN relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:I0005987 name: pcna-pold1-2 physical interaction comment: Interaction between PCNA, and CHAF1A identified by coimmunoprecipitation xref: IntAct:EBI-1202911 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001513 ! PCNA_HUMAN relationship: has_participant CCO:B0001742 ! CAF1A_HUMAN [Term] id: CCO:I0005988 name: pard6a-prkci-1 physical interaction comment: Interacting regions determined by Y2H. xref: IntAct:EBI-295346 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0005989 name: pard6a-prkcz-1 physical interaction comment: Interacting regions determined by Y2H. xref: IntAct:EBI-295374 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005315 ! KPCZ_HUMAN [Term] id: CCO:I0005990 name: pard6b-prkci-1 physical interaction comment: Interacting regions determined by Y2H. xref: IntAct:EBI-295401 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0005991 name: pard6b-prkcz-1 physical interaction comment: Interacting regions determined by Y2H. xref: IntAct:EBI-295414 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005315 ! KPCZ_HUMAN [Term] id: CCO:I0005992 name: pard6g-prkci-1 physical interaction comment: Interacting regions determined by Y2H. xref: IntAct:EBI-295426 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002112 ! PAR6G_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0005993 name: pard6a-rac1-2 physical interaction comment: Interaction detected by Y2H. xref: IntAct:EBI-295457 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005337 ! RAC1_HUMAN [Term] id: CCO:I0005994 name: pard6a-cdc42-4 physical interaction comment: Interaction detected by Y2H. xref: IntAct:EBI-295464 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0005995 name: pard6b-rac1-1 physical interaction comment: Interaction detected by Y2H. xref: IntAct:EBI-295468 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005337 ! RAC1_HUMAN [Term] id: CCO:I0005996 name: pard6b-cdc42-4 physical interaction comment: Interaction detected by Y2H : bait = cdc42, prey = par6b xref: IntAct:EBI-295472 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0005997 name: pard6g-rac1-1 physical interaction comment: Interaction detected by Y2H. xref: IntAct:EBI-295476 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002112 ! PAR6G_HUMAN relationship: has_participant CCO:B0005337 ! RAC1_HUMAN [Term] id: CCO:I0005998 name: pard6g-cdc42-1 physical interaction comment: Interaction detected by Y2H : bait = cdc42, prey = par6g xref: IntAct:EBI-295480 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002112 ! PAR6G_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0005999 name: cdc37-cdk4 physical interaction comment: Interaction of cdc37 and CDK4 demonstrated by Y2H xref: IntAct:EBI-295633 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001819 ! CDC37_HUMAN [Term] id: CCO:I0006002 name: rad51-brca2-1 physical interaction comment: Interaction of BRC4 repeat of BRCA2 with Rad51 determined by CoIP. xref: IntAct:EBI-297268 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0006006 name: tubg-mark4-2 physical interaction comment: Association of MARK4 with gamma tubulin, detected by immunoprecipitation. xref: IntAct:EBI-351976 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001548 ! TBG1_HUMAN relationship: has_participant CCO:B0005344 ! MARK4_HUMAN [Term] id: CCO:I0006007 name: tubg-mark4-3 physical interaction comment: Association of MARK4 with gamma tubulin, detected by immunoprecipitation. xref: IntAct:EBI-352004 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001548 ! TBG1_HUMAN relationship: has_participant CCO:B0005344 ! MARK4_HUMAN [Term] id: CCO:I0006011 name: rassf1-xpa physical interaction comment: Interaction between RASSF1 and XPA identified by Y2H xref: IntAct:EBI-367371 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002162 ! RASF1_HUMAN relationship: has_participant CCO:B0005345 ! XPA_HUMAN [Term] id: CCO:I0006012 name: mphosph6-kiaa0052 physical interaction xref: IntAct:EBI-374346 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005346 ! SK2L2_HUMAN [Term] id: CCO:I0006013 name: mphosph6-parn physical interaction xref: IntAct:EBI-374349 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005347 ! PARN_HUMAN [Term] id: CCO:I0006014 name: mphosph6-pmscl2 physical interaction xref: IntAct:EBI-374352 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005348 ! EXOSX_HUMAN [Term] id: CCO:I0006015 name: lsm8-rent1 physical interaction xref: IntAct:EBI-374478 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005349 ! LSM8_HUMAN [Term] id: CCO:I0006016 name: mdm2-mdm4-1 physical interaction comment: Yeast two-hybrid anlaysis identifies MDMX as an MDM2-binding protein. xref: IntAct:EBI-398450 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001366 ! MDM4_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0006017 name: e2f1-trrap-1 physical interaction comment: TRRAP and E2F1 interaction detected by coimmunoprecipitation xref: IntAct:EBI-448940 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001713 ! E2F1_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN [Term] id: CCO:I0006018 name: e2f4-trrap-1 physical interaction comment: TRRAP and E2F4 bind in vivo xref: IntAct:EBI-448954 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001817 ! E2F4_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN [Term] id: CCO:I0006019 name: htatip-trrap-1 physical interaction comment: Identification of subunits of human TIP60 histone acetylase complex. xref: IntAct:EBI-449133 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005351 ! TIP60_HUMAN [Term] id: CCO:I0006020 name: orc1-cdk2-1 physical interaction comment: Interaction of hORC1 with Cyclin A/CDK2 xref: IntAct:EBI-492332 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0005352 ! ORC1_HUMAN [Term] id: CCO:I0006021 name: orc1-orc2-1 physical interaction comment: Interaction of hORC1 with ORC2 xref: IntAct:EBI-492344 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0005353 ! ORC2_HUMAN [Term] id: CCO:I0006022 name: nbs1-h2afx-2 physical interaction xref: IntAct:EBI-494971 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:I0006023 name: taf1-gtf2f1-3 physical interaction comment: Human TAFII-250 interacts with RAP74 xref: IntAct:EBI-515429 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001543 ! TAF1_HUMAN relationship: has_participant CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:I0006024 name: cul1-cand1 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin1 protein and the TIP120A (CAND1) protein xref: IntAct:EBI-595237 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006027 name: uhrf2-cdk2-1 physical interaction comment: Interaction between UHRF2 (NIRF) and CDK2 identified by coimmunoprecipitation xref: IntAct:EBI-625345 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0002054 ! UHRF2_HUMAN [Term] id: CCO:I0006028 name: uhrf2-cdk2-3 physical interaction comment: Interaction between UHRF2 (NIRF) and CDK2 identified by coimmunoprecipitation xref: IntAct:EBI-625371 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0002054 ! UHRF2_HUMAN [Term] id: CCO:I0006029 name: npm1-tp53-2 physical interaction comment: coIP: bait = npm1; prey =p53 xref: IntAct:EBI-626555 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:I0006030 name: hcfc1-many-4 physical interaction comment: interaction cosedimentation of Hcfc1, Sin3A, Ash2 and Sp1 in high-molecular-weight complexes xref: IntAct:EBI-630171 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:I0006031 name: sept1-aurkb-5 phosphorylation comment: Interaction of Septin1 and Aurora-B identified by GST pulldown xref: IntAct:EBI-693058 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0002011 ! SEPT1_HUMAN relationship: has_participant CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:I0006032 name: wrn-rad52-9 colocalization comment: Colocalization of RAD52 and WRN xref: IntAct:EBI-706570 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006033 name: wrn-p53-3 colocalization comment: Colocalization of P53 and WRN in cells arrested in S phase xref: IntAct:EBI-708467 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006035 name: mrgbp-ruvbl1-1 physical interaction comment: MudPit analysis isolates proteins associated with MRGBP xref: IntAct:EBI-769767 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005360 ! MRGBP_HUMAN [Term] id: CCO:I0006036 name: tclf1-ruvbl1-2 physical interaction comment: MudPit analysis isolates proteins associated with TCLF1 xref: IntAct:EBI-769790 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN [Term] id: CCO:I0006037 name: znf-ruvbl1-3 physical interaction comment: MudPit analysis isolates proteins associated with ZNF xref: IntAct:EBI-769819 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005362 ! ZNHI1_HUMAN [Term] id: CCO:I0006038 name: tclf1-ruvbl1-3 physical interaction comment: MudPit analysis of phosphocellulose chromatography fractions isolates proteins associated with TCLF1 xref: IntAct:EBI-769938 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN relationship: has_participant CCO:B0005363 ! EAF1_HUMAN relationship: has_participant CCO:B0005364 ! RUVB2_HUMAN relationship: has_participant CCO:B0005365 ! DMAP1_HUMAN relationship: has_participant CCO:B0005366 ! ACL6A_HUMAN relationship: has_participant CCO:B0005367 ! ARP6_HUMAN [Term] id: CCO:I0006039 name: tclf1-ruvbl1-4 physical interaction comment: MudPit analysis of phosphocellulose chromatography fractions isolates proteins associated with TCLF1 xref: IntAct:EBI-777037 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005360 ! MRGBP_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN relationship: has_participant CCO:B0005362 ! ZNHI1_HUMAN relationship: has_participant CCO:B0005363 ! EAF1_HUMAN relationship: has_participant CCO:B0005364 ! RUVB2_HUMAN relationship: has_participant CCO:B0005365 ! DMAP1_HUMAN relationship: has_participant CCO:B0005366 ! ACL6A_HUMAN relationship: has_participant CCO:B0005367 ! ARP6_HUMAN relationship: has_participant CCO:B0005368 ! ING3_HUMAN relationship: has_participant CCO:B0005369 ! EPC1_HUMAN relationship: has_participant CCO:B0005370 ! MO4L2_HUMAN relationship: has_participant CCO:B0005371 ! EPC2_HUMAN [Term] id: CCO:I0006040 name: tclf1-ruvbl1-5 physical interaction comment: MudPit analysis of phosphocellulose chromatography fractions isolates proteins associated with TCLF1 xref: IntAct:EBI-777062 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005360 ! MRGBP_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN relationship: has_participant CCO:B0005363 ! EAF1_HUMAN relationship: has_participant CCO:B0005364 ! RUVB2_HUMAN relationship: has_participant CCO:B0005365 ! DMAP1_HUMAN relationship: has_participant CCO:B0005366 ! ACL6A_HUMAN relationship: has_participant CCO:B0005368 ! ING3_HUMAN relationship: has_participant CCO:B0005369 ! EPC1_HUMAN relationship: has_participant CCO:B0005371 ! EPC2_HUMAN [Term] id: CCO:I0006041 name: tclf1-ruvbl1-6 physical interaction comment: MudPit analysis of phosphocellulose chromatography fractions isolates proteins associated with TCLF1 xref: IntAct:EBI-777086 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005360 ! MRGBP_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN relationship: has_participant CCO:B0005363 ! EAF1_HUMAN relationship: has_participant CCO:B0005364 ! RUVB2_HUMAN relationship: has_participant CCO:B0005365 ! DMAP1_HUMAN relationship: has_participant CCO:B0005366 ! ACL6A_HUMAN relationship: has_participant CCO:B0005368 ! ING3_HUMAN [Term] id: CCO:I0006042 name: tclf1-ruvbl1-7 physical interaction comment: MudPit analysis of phosphocellulose chromatography fractions isolates proteins associated with TCLF1 xref: IntAct:EBI-777108 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN relationship: has_participant CCO:B0005362 ! ZNHI1_HUMAN relationship: has_participant CCO:B0005364 ! RUVB2_HUMAN relationship: has_participant CCO:B0005365 ! DMAP1_HUMAN relationship: has_participant CCO:B0005366 ! ACL6A_HUMAN relationship: has_participant CCO:B0005367 ! ARP6_HUMAN [Term] id: CCO:I0006043 name: adam9-mad2l2-3 physical interaction xref: IntAct:EBI-78229 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002204 ! MD2L2_HUMAN relationship: has_participant CCO:B0005372 ! ADAM9_HUMAN [Term] id: CCO:I0006044 name: hd52-hd53-1 physical interaction comment: Interaction between human D52 and human D53 detected by Y2H xref: IntAct:EBI-782601 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0005373 ! TPD52_HUMAN [Term] id: CCO:I0006045 name: hd53-hd52-1 physical interaction comment: Interaction between human D53 and human D52 detected by Y2H xref: IntAct:EBI-782630 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0005373 ! TPD52_HUMAN [Term] id: CCO:I0006046 name: hd53-hd53-1 physical interaction comment: Homodimerisation of human D53 detected by Y2H xref: IntAct:EBI-782638 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN [Term] id: CCO:I0006047 name: aplp2-apbb2-1 physical interaction comment: APLP2-FE65 co-ip xref: IntAct:EBI-79321 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002020 ! APBB2_HUMAN relationship: has_participant CCO:B0005374 ! APLP2_HUMAN [Term] id: CCO:I0006048 name: stk36-sufu-1 physical interaction comment: Interaction between STK36 (FUSED) and SUFU identified by coimmunoprecipitation xref: IntAct:EBI-863810 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005375 ! STK36_HUMAN [Term] id: CCO:I0006049 name: stk36-sufu-2 physical interaction comment: Interaction between STK36 (FUSED) and SUFU identified by coimmunoprecipitation xref: IntAct:EBI-863815 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005375 ! STK36_HUMAN [Term] id: CCO:I0006050 name: ep300-nap1l1-3 direct interaction xref: IntAct:EBI-923621 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005376 ! NP1L1_HUMAN [Term] id: CCO:I0006052 name: pa2g4-rb1-1 physical interaction xref: IntAct:EBI-925146 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:I0006053 name: rb1-pa2g4-2 physical interaction xref: IntAct:EBI-925284 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:I0006054 name: pa2g4-rb1-2 physical interaction xref: IntAct:EBI-925494 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:I0006055 name: pa2g4-e2f1-1 physical interaction xref: IntAct:EBI-925581 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001713 ! E2F1_HUMAN relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:I0006056 name: ap2g-ubc9-1 physical interaction comment: Interaction between human AP2 gamma and UBC9 detected by Y2H xref: IntAct:EBI-937323 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005377 ! AP2C_HUMAN [Term] id: CCO:I0006057 name: s100b-s100a6-1 physical interaction comment: Interaction between human S100B and S100A6 detected by Y2H xref: IntAct:EBI-945511 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001494 ! S10A6_HUMAN relationship: has_participant CCO:B0005378 ! S100B_HUMAN [Term] id: CCO:I0006058 name: cdknib-cdk4 physical interaction comment: Coimmunoprecipitaion reveals interaction between CDKN1B and CDK4 xref: IntAct:EBI-978118 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0006059 name: cdknib-cdk2 physical interaction comment: Coimmunoprecipitaion reveals interaction between CDKN1B and CDK2 xref: IntAct:EBI-978130 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0006062 name: ahr-aip colocalization xref: IntAct:EBI-993202 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0005380 ! AIP_HUMAN [Term] id: CCO:I0006063 name: ahr-aip-1 colocalization xref: IntAct:EBI-993238 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0005380 ! AIP_HUMAN [Term] id: CCO:I0006064 name: kntc2-spbc25-1 physical interaction xref: IntAct:EBI-1000194 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0006065 name: kntc2-spbc25-2 physical interaction xref: IntAct:EBI-1000254 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0006066 name: kntc2_zwint_5 physical interaction comment: coIP: bait=kntc2, prey=zw10, zwint xref: IntAct:EBI-1001649 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0006070 name: tp53-nfya-8 colocalization xref: IntAct:EBI-1040916 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN [Term] id: CCO:I0006071 name: abl1-rin1-3 physical interaction comment: Interaction between Abl1 and Rin1 identified by coimmunoprecipitation xref: IntAct:EBI-1102773 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005385 ! RIN1_HUMAN [Term] id: CCO:I0006072 name: fnbp1-dnm2-2 physical interaction xref: IntAct:EBI-1111827 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0005386 ! FNBP1_HUMAN [Term] id: CCO:I0006073 name: ttn-tcap direct interaction xref: IntAct:EBI-1153057 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005387 ! TELT_HUMAN [Term] id: CCO:I0006074 name: mcm2-orc6l direct interaction xref: IntAct:EBI-375119 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0005388 ! ORC6_HUMAN [Term] id: CCO:I0006075 name: orc1l-hscdc6 direct interaction xref: IntAct:EBI-375122 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0005352 ! ORC1_HUMAN [Term] id: CCO:I0006076 name: orc1l-hscdc5 direct interaction xref: IntAct:EBI-375125 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005352 ! ORC1_HUMAN [Term] id: CCO:I0006078 name: mcm2-mcm3 direct interaction xref: IntAct:EBI-375131 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:I0006079 name: orc4l-mcm7 direct interaction xref: IntAct:EBI-375134 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0005389 ! ORC4_HUMAN [Term] id: CCO:I0006080 name: mcm5-mcm3 direct interaction xref: IntAct:EBI-375137 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0001588 ! MCM5_HUMAN [Term] id: CCO:I0006081 name: orc6l-mcm6 direct interaction xref: IntAct:EBI-375140 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0005388 ! ORC6_HUMAN [Term] id: CCO:I0006083 name: mcm10-mcm2 direct interaction xref: IntAct:EBI-375158 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006084 name: mcm2-orc2l direct interaction xref: IntAct:EBI-375161 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0005353 ! ORC2_HUMAN [Term] id: CCO:I0006085 name: mcm10-mcm6 direct interaction xref: IntAct:EBI-375167 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006086 name: mcm2-mcm5 direct interaction xref: IntAct:EBI-375170 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001588 ! MCM5_HUMAN relationship: has_participant CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:I0006088 name: orc5l-cdc45l direct interaction xref: IntAct:EBI-375176 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001426 ! CC45L_HUMAN relationship: has_participant CCO:B0005390 ! ORC5_HUMAN [Term] id: CCO:I0006089 name: mcm2-cdk6 direct interaction xref: IntAct:EBI-375179 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:I0006090 name: orc6l-cdc7 direct interaction xref: IntAct:EBI-375188 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0005388 ! ORC6_HUMAN [Term] id: CCO:I0006091 name: orc4l-ccnd1 direct interaction xref: IntAct:EBI-375191 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0005389 ! ORC4_HUMAN [Term] id: CCO:I0006092 name: mcm10-cdc7 direct interaction xref: IntAct:EBI-375197 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006093 name: mcm3-orc5l direct interaction xref: IntAct:EBI-375200 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0005390 ! ORC5_HUMAN [Term] id: CCO:I0006094 name: mcm3-hscdc5 direct interaction xref: IntAct:EBI-375203 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN [Term] id: CCO:I0006095 name: mcm10-mcm3 direct interaction xref: IntAct:EBI-375206 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006096 name: orc4l-mcm3 direct interaction xref: IntAct:EBI-375209 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0005389 ! ORC4_HUMAN [Term] id: CCO:I0006097 name: orc2l-hscdc5 direct interaction xref: IntAct:EBI-375212 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005353 ! ORC2_HUMAN [Term] id: CCO:I0006098 name: mcm10-ccnd3 direct interaction xref: IntAct:EBI-375215 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006099 name: mcm4-hscdc5 direct interaction xref: IntAct:EBI-375218 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:I0006100 name: orc2l-hscdc6 direct interaction xref: IntAct:EBI-375221 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0005353 ! ORC2_HUMAN [Term] id: CCO:I0006101 name: mcm10-hscdc5 direct interaction xref: IntAct:EBI-375224 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001929 ! MCM10_HUMAN relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN [Term] id: CCO:I0006102 name: mcm2-ccnb2 direct interaction xref: IntAct:EBI-375227 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001446 ! CCNB2_HUMAN relationship: has_participant CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:I0006103 name: mcm6-mcm6 direct interaction xref: IntAct:EBI-375230 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:I0006104 name: mcm10-hscdc6 direct interaction xref: IntAct:EBI-375233 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001929 ! MCM10_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN [Term] id: CCO:I0006105 name: mcm10-ccnd1 direct interaction xref: IntAct:EBI-375236 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006106 name: mcm10-mcm7 direct interaction xref: IntAct:EBI-375242 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006107 name: orc3l-ccne2 direct interaction xref: IntAct:EBI-375245 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001460 ! CCNE2_HUMAN relationship: has_participant CCO:B0005392 ! ORC3_HUMAN [Term] id: CCO:I0006108 name: mcm2-mcm7 direct interaction xref: IntAct:EBI-375248 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:I0006109 name: mcm7-orc3l direct interaction xref: IntAct:EBI-375251 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0005392 ! ORC3_HUMAN [Term] id: CCO:I0006110 name: mcm2-orc5l direct interaction xref: IntAct:EBI-375254 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0005390 ! ORC5_HUMAN [Term] id: CCO:I0006111 name: mcm2-hscdc6 direct interaction xref: IntAct:EBI-375263 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN [Term] id: CCO:I0006112 name: cdk6-cdkn2a direct interaction xref: IntAct:EBI-375266 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:I0006113 name: cdk4-cdkn2a direct interaction xref: IntAct:EBI-375269 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN [Term] id: CCO:I0006114 name: mcm6-ccna1 direct interaction xref: IntAct:EBI-375272 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:I0006115 name: cdkn2a-gmnn direct interaction xref: IntAct:EBI-375275 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001432 ! GEMI_HUMAN relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN [Term] id: CCO:I0006117 name: orc4l-cdkn2a direct interaction xref: IntAct:EBI-375281 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0005389 ! ORC4_HUMAN [Term] id: CCO:I0006119 name: mcm10-cdk6 direct interaction xref: IntAct:EBI-375293 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001708 ! CDK6_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006120 name: cdkn1a-ccnd3 direct interaction xref: IntAct:EBI-375296 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006121 name: mcm6-gmnn direct interaction xref: IntAct:EBI-375299 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001432 ! GEMI_HUMAN relationship: has_participant CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:I0006122 name: hscdc6-orc5l direct interaction xref: IntAct:EBI-375302 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0005390 ! ORC5_HUMAN [Term] id: CCO:I0006123 name: orc3l-hscdc6 direct interaction xref: IntAct:EBI-375305 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0005392 ! ORC3_HUMAN [Term] id: CCO:I0006124 name: hscdc6-orc6l direct interaction xref: IntAct:EBI-375311 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0005388 ! ORC6_HUMAN [Term] id: CCO:I0006126 name: orc6l-mcm7 direct interaction xref: IntAct:EBI-375317 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0005388 ! ORC6_HUMAN [Term] id: CCO:I0006127 name: cdk2-ccne2 direct interaction xref: IntAct:EBI-375320 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001460 ! CCNE2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006128 name: cdkn2a-hscdc6 direct interaction xref: IntAct:EBI-375323 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN [Term] id: CCO:I0006129 name: cdk4-ccnd3 direct interaction comment: protein array : bait = cdk4, prey = cyclin D3 xref: IntAct:EBI-375326 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001574 ! CCND3_HUMAN [Term] id: CCO:I0006130 name: mcm2-cdk4 direct interaction xref: IntAct:EBI-375329 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:I0006131 name: cdk6-ccnd3 direct interaction xref: IntAct:EBI-375332 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:I0006132 name: cdkn1a-ccne2 direct interaction xref: IntAct:EBI-375335 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001460 ! CCNE2_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006133 name: cdkn2a-orc5l direct interaction xref: IntAct:EBI-375338 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0005390 ! ORC5_HUMAN [Term] id: CCO:I0006134 name: cdk4-ccnd1 direct interaction comment: protein array : bait = cdk4, prey = cyclin D1 xref: IntAct:EBI-375341 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN [Term] id: CCO:I0006135 name: cdkn1a-cdc45l direct interaction xref: IntAct:EBI-375344 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001426 ! CC45L_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006136 name: cdkn1a-hscdc6 direct interaction xref: IntAct:EBI-375347 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN [Term] id: CCO:I0006137 name: cdkn1a-cdc7 direct interaction xref: IntAct:EBI-375350 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006138 name: cdc7-orc5l direct interaction xref: IntAct:EBI-375353 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0005390 ! ORC5_HUMAN [Term] id: CCO:I0006139 name: cdkn2a-cdc45l direct interaction xref: IntAct:EBI-375356 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001426 ! CC45L_HUMAN relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN [Term] id: CCO:I0006140 name: cdkn1a-ccnd1 direct interaction xref: IntAct:EBI-375359 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006141 name: cdkn2a-cdc7 direct interaction xref: IntAct:EBI-375362 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN [Term] id: CCO:I0006142 name: mcm2-cdkn2a direct interaction xref: IntAct:EBI-375365 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0001631 ! MCM2_HUMAN [Term] id: CCO:I0006143 name: cdk6-ccnd1 direct interaction xref: IntAct:EBI-375368 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:I0006144 name: mcm7-mcm5 direct interaction xref: IntAct:EBI-375371 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001588 ! MCM5_HUMAN relationship: has_participant CCO:B0001589 ! MCM7_HUMAN [Term] id: CCO:I0006145 name: cdkn2a-mcm10 direct interaction xref: IntAct:EBI-375374 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006146 name: mcm3-cdc7 direct interaction xref: IntAct:EBI-375380 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:I0006147 name: cdkn1a-hscdc5 direct interaction xref: IntAct:EBI-375383 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN [Term] id: CCO:I0006148 name: cdkn1a-cdk6 direct interaction xref: IntAct:EBI-375386 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:I0006149 name: cdkn1a-ccnb2 direct interaction xref: IntAct:EBI-375392 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001446 ! CCNB2_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006150 name: orc2l-cdk2 direct interaction xref: IntAct:EBI-375395 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0005353 ! ORC2_HUMAN [Term] id: CCO:I0006151 name: cdkn2a-mcm5 direct interaction xref: IntAct:EBI-375398 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001588 ! MCM5_HUMAN relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN [Term] id: CCO:I0006152 name: cdkn1a-cdk4 direct interaction xref: IntAct:EBI-375404 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006153 name: mcm4-mcm7 direct interaction xref: IntAct:EBI-375407 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:I0006154 name: mcm3-hscdc6 direct interaction xref: IntAct:EBI-375410 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN [Term] id: CCO:I0006155 name: cdk2-ccnb2 direct interaction xref: IntAct:EBI-375413 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001446 ! CCNB2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006156 name: cdkn1a-ccna1 direct interaction xref: IntAct:EBI-375416 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN [Term] id: CCO:I0006157 name: mcm4-ccna1 direct interaction xref: IntAct:EBI-375419 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:I0006158 name: mcm3-cdk2 direct interaction xref: IntAct:EBI-375425 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001558 ! MCM3_HUMAN [Term] id: CCO:I0006159 name: cdkn1a-cdk2 direct interaction xref: IntAct:EBI-375428 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006160 name: cdkn1a-gmnn direct interaction xref: IntAct:EBI-375431 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001432 ! GEMI_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006161 name: cdkn1a-mcm10 direct interaction xref: IntAct:EBI-375434 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0001929 ! MCM10_HUMAN [Term] id: CCO:I0006162 name: cdc7-cdk4 direct interaction xref: IntAct:EBI-375437 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0001512 ! CDK4_HUMAN [Term] id: CCO:I0006163 name: mcm3-mcm6 direct interaction xref: IntAct:EBI-375440 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0001785 ! MCM6_HUMAN [Term] id: CCO:I0006164 name: nek1-fez1-2 physical interaction comment: Interaction between NEK1 and FEZ1 confirmed by GST pull down xref: IntAct:EBI-396654 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005393 ! FEZ1_HUMAN [Term] id: CCO:I0006165 name: nek1-fez2-1 physical interaction comment: Interaction between NEK1 and FEZ-2 confirmed by GST pull down xref: IntAct:EBI-396661 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005394 ! FEZ2_HUMAN [Term] id: CCO:I0006166 name: bard1-htatip physical interaction xref: IntAct:EBI-474165 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005351 ! TIP60_HUMAN [Term] id: CCO:I0006167 name: bard1-zhx1 physical interaction xref: IntAct:EBI-474172 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005395 ! ZHX1_HUMAN [Term] id: CCO:I0006168 name: bard1-tcerg1-1 physical interaction xref: IntAct:EBI-474179 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005396 ! TCRG1_HUMAN [Term] id: CCO:I0006169 name: bard1-git1-1 physical interaction xref: IntAct:EBI-474186 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:I0006170 name: bard1-ikbkap physical interaction xref: IntAct:EBI-474193 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005398 ! ELP1_HUMAN [Term] id: CCO:I0006171 name: bard1-hbo1-1 physical interaction xref: IntAct:EBI-474200 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:I0006172 name: bard1-bp465 physical interaction xref: IntAct:EBI-474207 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005400 ! BRD7_HUMAN [Term] id: CCO:I0006173 name: bard1-kbtbd7 physical interaction xref: IntAct:EBI-474214 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005401 ! KBTB7_HUMAN [Term] id: CCO:I0006174 name: bard1-pias4 physical interaction xref: IntAct:EBI-474221 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005402 ! PIAS4_HUMAN [Term] id: CCO:I0006175 name: bard1-kiaa1377-1 physical interaction xref: IntAct:EBI-474235 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0006176 name: bard1-setdb1 physical interaction comment: Y2H : BARD1 and SETDB1 xref: IntAct:EBI-474242 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:I0006177 name: bard1-ptn physical interaction xref: IntAct:EBI-474256 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001541 ! PTN_HUMAN relationship: has_participant CCO:B0002086 ! BARD1_HUMAN [Term] id: CCO:I0006178 name: bard1-gprasp2 physical interaction xref: IntAct:EBI-474270 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005405 ! GASP2_HUMAN [Term] id: CCO:I0006179 name: bard1-fez1 physical interaction xref: IntAct:EBI-474284 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005393 ! FEZ1_HUMAN [Term] id: CCO:I0006183 name: hd-mtss1 physical interaction xref: IntAct:EBI-474739 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001390 ! MTSS1_HUMAN relationship: has_participant CCO:B0005407 ! HD_HUMAN [Term] id: CCO:I0006184 name: hd-mtss1-1 physical interaction xref: IntAct:EBI-474746 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001390 ! MTSS1_HUMAN relationship: has_participant CCO:B0005407 ! HD_HUMAN [Term] id: CCO:I0006185 name: hd-mtss1-2 physical interaction xref: IntAct:EBI-474753 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001390 ! MTSS1_HUMAN relationship: has_participant CCO:B0005407 ! HD_HUMAN [Term] id: CCO:I0006186 name: ok/sw_cl_16-kpna2 physical interaction xref: IntAct:EBI-474984 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001657 ! IMA2_HUMAN relationship: has_participant CCO:B0005408 ! Q8NI70_HUMAN [Term] id: CCO:I0006187 name: mageh1-kpna2 physical interaction xref: IntAct:EBI-474991 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001657 ! IMA2_HUMAN relationship: has_participant CCO:B0005406 ! MAGH1_HUMAN [Term] id: CCO:I0006188 name: kiaa1377-kpna2 physical interaction xref: IntAct:EBI-474998 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001657 ! IMA2_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0006196 name: rb1-taf1-1 physical interaction comment: Rb inhibits the intrinsic kinase acitivity of TAFII250, detected by GST pull-down. xref: IntAct:EBI-491318 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001543 ! TAF1_HUMAN [Term] id: CCO:I0006197 name: orc1-skp2-2 physical interaction comment: Interaction of hORC1 with SKP2 xref: IntAct:EBI-492430 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0005352 ! ORC1_HUMAN [Term] id: CCO:I0006198 name: h2ax-tp53bp1-1 physical interaction xref: IntAct:EBI-495664 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001526 ! H2AX_HUMAN relationship: has_participant CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:I0006199 name: taf1-gtf2f1-1 physical interaction comment: Human TAFII-250 interacts with RAP74. xref: IntAct:EBI-515106 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001543 ! TAF1_HUMAN relationship: has_participant CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:I0006200 name: taf1-gtf2f1-2 physical interaction comment: Human TAFII-250 inteacts with RAP74 xref: IntAct:EBI-515162 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001543 ! TAF1_HUMAN relationship: has_participant CCO:B0005354 ! T2FA_HUMAN [Term] id: CCO:I0006201 name: ccne1-nbs1-1 physical interaction xref: IntAct:EBI-520650 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN [Term] id: CCO:I0006202 name: ccne1-mre11a-1 physical interaction xref: IntAct:EBI-520656 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001641 ! MRE11_HUMAN [Term] id: CCO:I0006203 name: abl1-ywhaz-1 physical interaction comment: Interaction of ABL1 with 14-3-3 zeta protein demonstrated by coimmunoprecipitation xref: IntAct:EBI-593857 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0006204 name: abl1-snf-1 physical interaction comment: Interaction of ABL1 with 14-3-3 sigma protein demonstrated by coimmunoprecipitation xref: IntAct:EBI-593877 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0001584 ! 1433S_HUMAN [Term] id: CCO:I0006205 name: smarca4-pb1-arid2-1 physical interaction comment: PBAF complex by chromatography analyzed by MS xref: IntAct:EBI-638253 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0001938 ! PB1_HUMAN relationship: has_participant CCO:B0005366 ! ACL6A_HUMAN relationship: has_participant CCO:B0005414 ! SMCA4_HUMAN relationship: has_participant CCO:B0005415 ! SMRD1_HUMAN relationship: has_participant CCO:B0005416 ! SMCE1_HUMAN relationship: has_participant CCO:B0005417 ! SMRC2_HUMAN relationship: has_participant CCO:B0005418 ! SMRC1_HUMAN relationship: has_participant CCO:B0005419 ! SMRD2_HUMAN [Term] id: CCO:I0006206 name: sept1-aurkb-2 physical interaction comment: Interaction of Septin1 and Aurora-B identified by GST pulldown xref: IntAct:EBI-693019 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002011 ! SEPT1_HUMAN relationship: has_participant CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:I0006207 name: bcl2-bax-2 physical interaction comment: Interaction of Bcl-2 with Bax demonstrated by coimmunoprecipitation xref: IntAct:EBI-700753 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001506 ! BCL2_HUMAN relationship: has_participant CCO:B0001723 ! BAX_HUMAN [Term] id: CCO:I0006212 name: wrn-terf2-3 colocalization comment: Colocalization of WRM and TRF2 (TERF2) xref: IntAct:EBI-706680 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006213 name: dnmt3b-ube2i-2 physical interaction xref: IntAct:EBI-80234 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005423 ! DNM3B_HUMAN [Term] id: CCO:I0006214 name: rabgef1-egfr physical interaction xref: IntAct:EBI-921718 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005424 ! EP15_HUMAN [Term] id: CCO:I0006215 name: atxn1-ccnk physical interaction xref: IntAct:EBI-946374 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0006216 name: cenpj-gfi1b physical interaction xref: IntAct:EBI-946647 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005426 ! CENPJ_HUMAN [Term] id: CCO:I0006217 name: gfi1b-jag2 physical interaction xref: IntAct:EBI-946654 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0002245 ! JAG2_HUMAN [Term] id: CCO:I0006218 name: gfi1b-nell2 physical interaction xref: IntAct:EBI-946661 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005427 ! NELL2_HUMAN [Term] id: CCO:I0006219 name: s100b-s100a6-3 physical interaction comment: Interaction between human S100B and S100A6 detected by coIP xref: IntAct:EBI-959913 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001494 ! S10A6_HUMAN relationship: has_participant CCO:B0005378 ! S100B_HUMAN [Term] id: CCO:I0006220 name: csnk2a1-pml-1 phosphorylation xref: IntAct:EBI-983553 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001570 ! PML_HUMAN relationship: has_participant CCO:B0005428 ! CSK21_HUMAN [Term] id: CCO:I0006221 name: mdm2-daxx physical interaction xref: IntAct:EBI-992074 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0006222 name: ubp7-daxx physical interaction xref: IntAct:EBI-992485 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:I0006223 name: pcaf-hif1a physical interaction xref: IntAct:EBI-996429 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:I0006224 name: spbc24-spbc25-4 physical interaction xref: IntAct:EBI-1000026 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0006225 name: cdca1_cenpb_1 colocalization xref: IntAct:EBI-1002609 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0002115 ! NUF2_HUMAN relationship: has_participant CCO:B0005431 ! CENPB_HUMAN [Term] id: CCO:I0006226 name: kntc2_cenpb_1 colocalization xref: IntAct:EBI-1002612 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0005431 ! CENPB_HUMAN [Term] id: CCO:I0006227 name: smc1-mcm7-2 physical interaction comment: Interaction between human Smc1 and MCM7 detected by TAP xref: IntAct:EBI-1004670 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0006228 name: rent1-dcp2 physical interaction xref: IntAct:EBI-1013186 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005432 ! DCP1A_HUMAN relationship: has_participant CCO:B0005433 ! DCP2_HUMAN [Term] id: CCO:I0006229 name: dcp1a-upf1 physical interaction xref: IntAct:EBI-1013264 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005432 ! DCP1A_HUMAN [Term] id: CCO:I0006230 name: dcp2-upf physical interaction xref: IntAct:EBI-1013281 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005433 ! DCP2_HUMAN [Term] id: CCO:I0006231 name: upf1-dcp1a-2 physical interaction xref: IntAct:EBI-1013658 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005432 ! DCP1A_HUMAN relationship: has_participant CCO:B0005434 ! REN3B_HUMAN relationship: has_participant CCO:B0005435 ! RENT2_HUMAN relationship: has_participant CCO:B0005436 ! REN3A_HUMAN [Term] id: CCO:I0006232 name: bmp2-bmpr1a-1 direct interaction comment: Complex between bmp-2 and two bmp receptor ia ectodomains xref: IntAct:EBI-1029281 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001515 ! BMP2_HUMAN relationship: has_participant CCO:B0005437 ! BMR1A_HUMAN [Term] id: CCO:I0006236 name: hgf-met-1 direct interaction comment: The crystal structure of hgf beta-chain in complex with the sema domain of the met receptor. xref: IntAct:EBI-1039192 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001518 ! HGF_HUMAN relationship: has_participant CCO:B0005438 ! MET_HUMAN [Term] id: CCO:I0006238 name: pard6a-prkci-3 direct interaction comment: Crystal structure of a pb1 domain complex of protein kinase c iota and par6 alpha xref: IntAct:EBI-1041315 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0006239 name: upf1-dcp1a-3 physical interaction xref: IntAct:EBI-1149045 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005432 ! DCP1A_HUMAN relationship: has_participant CCO:B0005434 ! REN3B_HUMAN relationship: has_participant CCO:B0005435 ! RENT2_HUMAN relationship: has_participant CCO:B0005436 ! REN3A_HUMAN [Term] id: CCO:I0006240 name: upf1-dcp1a-4 physical interaction xref: IntAct:EBI-1149055 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005432 ! DCP1A_HUMAN relationship: has_participant CCO:B0005434 ! REN3B_HUMAN relationship: has_participant CCO:B0005436 ! REN3A_HUMAN [Term] id: CCO:I0006241 name: upf1-dcp1a-5 physical interaction xref: IntAct:EBI-1149083 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005432 ! DCP1A_HUMAN [Term] id: CCO:I0006242 name: fbxo25-cul1-1 physical interaction comment: Interaction between FBXO25, CUL1 and SKP1A demonstrated by coimmunoprecipitation xref: IntAct:EBI-1161147 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005440 ! FBX25_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006243 name: fbxo4-cul1-2 physical interaction comment: Interaction between FBXO4, CUL1 and SKP1A demonstrated by coimmunoprecipitation xref: IntAct:EBI-1161214 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005441 ! FBX4_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006244 name: fbxo7-cul1-1 physical interaction comment: Interaction between FBXO7, CUL1 and SKP1A demonstrated by coimmunoprecipitation xref: IntAct:EBI-1161237 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005442 ! FBX7_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006246 name: tp53-fbxo11-3 physical interaction comment: Interaction between p53 and FBX011 identified by pulldown xref: IntAct:EBI-1168057 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005332 ! FBX11_HUMAN [Term] id: CCO:I0006247 name: ctcf-chd8-5 colocalization xref: IntAct:EBI-1169215 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001630 ! CTCF_HUMAN relationship: has_participant CCO:B0005444 ! CHD8_HUMAN [Term] id: CCO:I0006248 name: nf1-sdc2 physical interaction comment: In a yeast two-hybrid assay neurofibromin binds syndecan-2 xref: IntAct:EBI-1172967 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001542 ! NF1_HUMAN relationship: has_participant CCO:B0005445 ! SDC2_HUMAN [Term] id: CCO:I0006249 name: nf1-sdc2-1 physical interaction comment: In a yeast two-hybrid assay neurofibromin binds syndecan-2 xref: IntAct:EBI-1172987 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001542 ! NF1_HUMAN relationship: has_participant CCO:B0005445 ! SDC2_HUMAN [Term] id: CCO:I0006250 name: nf1-sdc2-3 physical interaction comment: In a yeast two-hybrid assay neurofibromin binds syndecan-2 xref: IntAct:EBI-1173237 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001542 ! NF1_HUMAN relationship: has_participant CCO:B0005445 ! SDC2_HUMAN [Term] id: CCO:I0006251 name: nf1-sdc2-4 physical interaction comment: In a yeast two-hybrid assay neurofibromin binds syndecan-2 xref: IntAct:EBI-1173256 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001542 ! NF1_HUMAN relationship: has_participant CCO:B0005445 ! SDC2_HUMAN [Term] id: CCO:I0006252 name: atm-aatf-1 phosphorylation comment: Che-1 is phosphorylated by ATM in vitro xref: IntAct:EBI-1180754 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001750 ! ATM_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0006253 name: atr-aatf-2 phosphorylation comment: Che-1 is phosphorylated by ATR in vitro xref: IntAct:EBI-1180766 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001756 ! ATR_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0006254 name: chek2-aatf-2 phosphorylation comment: Che-1 is phosphorylated by Chk2 in vitro xref: IntAct:EBI-1180914 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001459 ! CHK2_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0006255 name: chek1-aatf phosphorylation comment: Che-1 is phosphorylated by Chk1 in vitro xref: IntAct:EBI-1180941 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001359 ! CHK1_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0006256 name: atm-aatf-2 phosphorylation comment: Che-1 is phosphorylated by ATM in vitro xref: IntAct:EBI-1181015 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001750 ! ATM_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0006257 name: chek2-aatf-3 phosphorylation comment: Che-1 is phosphorylated by Chk2 in vitro xref: IntAct:EBI-1181029 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001459 ! CHK2_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0006258 name: qsk-ywhaz-3 physical interaction comment: Interaction between 14-3-3Z , QSK and SNF1LK identified by pulldown xref: IntAct:EBI-1181833 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001680 ! SN1L1_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0006260 name: csnk1e-apc phosphorylation comment: CKI epsilon phosphorylates APC peptide in an in vitro phosphorylation assay xref: IntAct:EBI-1187596 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0005272 ! KC1E_HUMAN [Term] id: CCO:I0006261 name: egfr-calm-cav1 physical interaction xref: IntAct:EBI-1188138 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001584 ! 1433S_HUMAN relationship: has_participant CCO:B0001690 ! CALM_HUMAN relationship: has_participant CCO:B0005448 ! CLCA_HUMAN relationship: has_participant CCO:B0005449 ! TBA4A_HUMAN relationship: has_participant CCO:B0005450 ! ICAM1_HUMAN relationship: has_participant CCO:B0005451 ! HXC10_HUMAN relationship: has_participant CCO:B0005452 ! SEC13_HUMAN relationship: has_participant CCO:B0005453 ! AT1B1_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN relationship: has_participant CCO:B0005455 ! CD166_HUMAN relationship: has_participant CCO:B0005456 ! CAV1_HUMAN relationship: has_participant CCO:B0005457 ! LYN_HUMAN relationship: has_participant CCO:B0005458 ! G3P_HUMAN relationship: has_participant CCO:B0005459 ! AT1A1_HUMAN relationship: has_participant CCO:B0005460 ! CLH2_HUMAN relationship: has_participant CCO:B0005461 ! S10A9_HUMAN relationship: has_participant CCO:B0005462 ! CAV2_HUMAN relationship: has_participant CCO:B0005463 ! 4F2_HUMAN [Term] id: CCO:I0006262 name: src-cdn1b-1 phosphorylation comment: Phosphorylation of CDN1B by Src xref: IntAct:EBI-1200966 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005464 ! SRC_HUMAN [Term] id: CCO:I0006263 name: yes-cdn1b-1 phosphorylation comment: Phosphorylation of CDN1B by Yes xref: IntAct:EBI-1201061 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005465 ! YES_HUMAN [Term] id: CCO:I0006266 name: cdc2l1-pak1-1 physical interaction comment: CDC2L1-PAK1 identified by Y2H xref: IntAct:EBI-1313 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001540 ! CD2L1_HUMAN relationship: has_participant CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:I0006271 name: pml-ubl_1-1 physical interaction comment: Interaction detected by Y2H. xref: IntAct:EBI-367073 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001570 ! PML_HUMAN relationship: has_participant CCO:B0005472 ! SUMO1_HUMAN [Term] id: CCO:I0006278 name: egfr-grb2 physical interaction comment: in vitro interaction of egfr and grb2. xref: IntAct:EBI-370904 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN [Term] id: CCO:I0006279 name: app-apbb1-2 physical interaction comment: app-fe65 in vivo interaction. xref: IntAct:EBI-371417 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006281 name: fancd2-brca2-2 physical interaction comment: Interaction between FACD2 and BRCA2 confirmed by co-immunoprecipitation xref: IntAct:EBI-446109 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:I0006282 name: ywhaz-egfr-1 physical interaction comment: EGFR and 14-3-3 zeta interaction detected by filter binding xref: IntAct:EBI-446460 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0006285 name: igf1r-shc1-1 physical interaction comment: Interaction between IGF receptor1 and Shc1 demonstrated by Y2H xref: IntAct:EBI-517606 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001497 ! IGF1R_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN [Term] id: CCO:I0006286 name: insr-shc1-1 physical interaction comment: Interaction between Insulin receptor1 and Shc1 demonstrated by Y2H xref: IntAct:EBI-517611 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005478 ! INSR_HUMAN [Term] id: CCO:I0006290 name: cdkn1a-ccne1-2 physical interaction comment: GST pull down : bait= cyclin E1, prey = p21-CIP1 xref: IntAct:EBI-519575 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006291 name: cdkn1b-ccne1-1 physical interaction comment: GST pull down : bait= cyclin E1, prey = p27-KIP xref: IntAct:EBI-519585 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0006292 name: cdkn1b-ccnb1-1 physical interaction comment: GST pull down : bait= cyclin B1 , prey = p27-KIP xref: IntAct:EBI-519593 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001519 ! CCNB1_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0006293 name: cdkn1a-ccne1-3 physical interaction comment: GST pull down : bait=p21-CIP1, prey = cyclin E1 xref: IntAct:EBI-519606 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006294 name: cdkn1a-cdk2-1 physical interaction comment: GST pull down : bait= p21-CIP1, prey = cdk2 xref: IntAct:EBI-519614 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006295 name: cdk2-ccne1-1 physical interaction comment: GST pull down : bait= cyclin E1, prey = cdk2 xref: IntAct:EBI-519628 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006297 name: cdkn1a-ccne1-4 physical interaction comment: GST pull down : bait= cyclin E1, prey = p21-CIP1 xref: IntAct:EBI-519714 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006298 name: tbp-taf1-2 physical interaction comment: Interaction between TAFII-250 and TBP, detected by Y2H. xref: IntAct:EBI-520086 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001543 ! TAF1_HUMAN relationship: has_participant CCO:B0005481 ! TBP_HUMAN [Term] id: CCO:I0006299 name: dapk-erk physical interaction comment: GST-pulldown reveals interaction between death-associated protein kinase 1protein and the mitogen-activated protein kinase 3 protein xref: IntAct:EBI-525573 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001560 ! MK03_HUMAN relationship: has_participant CCO:B0005482 ! DAPK1_HUMAN [Term] id: CCO:I0006300 name: dapk-erk-3 physical interaction comment: GST-pulldown reveals amino acid residues of the D domain of the death-associated protein kinase 1protein required for association with the mitogen-activated protein kinase 3 protein xref: IntAct:EBI-525646 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001560 ! MK03_HUMAN relationship: has_participant CCO:B0005482 ! DAPK1_HUMAN [Term] id: CCO:I0006301 name: rent1-stau-2 physical interaction xref: IntAct:EBI-536599 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005483 ! STAU1_HUMAN [Term] id: CCO:I0006302 name: hcfc1-hdac1-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and hdac1 xref: IntAct:EBI-540482 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0006303 name: hcfc1-hdac2-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and hdac2 xref: IntAct:EBI-540490 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:I0006304 name: hcfc1-sp1-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and sp1 xref: IntAct:EBI-540512 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005485 ! SP1_HUMAN [Term] id: CCO:I0006305 name: mll-hcfc2-2 physical interaction comment: MLL associates with a cohort of proteins, detected by coimmunoprecipitation. xref: IntAct:EBI-592993 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005486 ! HRX_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:I0006307 name: abl1-ywhab-1 physical interaction comment: Interaction of ABL1 with 14-3-3 proteins demonstrated by coimmunoprecipitation xref: IntAct:EBI-593829 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0001584 ! 1433S_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN relationship: has_participant CCO:B0005480 ! 1433B_HUMAN relationship: has_participant CCO:B0005488 ! 1433E_HUMAN relationship: has_participant CCO:B0005489 ! 1433G_HUMAN relationship: has_participant CCO:B0005490 ! 1433F_HUMAN [Term] id: CCO:I0006308 name: cul1-cand1-4 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin1 protein and the TIP120A (CAND1) protein xref: IntAct:EBI-597772 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006309 name: cul1-cand1-5 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin1 protein and the TIP120A (CAND1) protein xref: IntAct:EBI-597861 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006310 name: cul1-cand1-6 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin1 protein, TIP120A (CAND1) protein, RBX1 protein and SKP1 protein xref: IntAct:EBI-598059 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN [Term] id: CCO:I0006311 name: numa1-gpsm2-1 physical interaction xref: IntAct:EBI-618688 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:I0006312 name: numa1-gnai1-1 physical interaction xref: IntAct:EBI-618699 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0005492 ! GPSM2_HUMAN relationship: has_participant CCO:B0005493 ! GNAI1_HUMAN [Term] id: CCO:I0006313 name: hcfc1-zbtb17-9 physical interaction comment: GST pull-down to identify which region(s) of zbtb17 (Miz1) are required for interaction with hcfc1. xref: IntAct:EBI-624221 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0006314 name: tacc1-lsm7-2 physical interaction comment: Identification of regions of TACC1 which binds to LSM7 by Y2H xref: IntAct:EBI-624677 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0005494 ! LSM7_HUMAN [Term] id: CCO:I0006315 name: tacc1-snrpg-2 physical interaction comment: Regions of TACC1 which bind SNRPG1 (SmG) identified by Y2H xref: IntAct:EBI-624683 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0005495 ! RUXG_HUMAN [Term] id: CCO:I0006316 name: tacc1-tdrd7-6 physical interaction comment: Identification of regions of TACC1 which interact with TDRD7 (TRAP) by Y2H xref: IntAct:EBI-624693 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0005496 ! TDRD7_HUMAN [Term] id: CCO:I0006317 name: tacc1-chtog-8 colocalization comment: TACC1, chTOG and STK6 (Aurora A) colocalise during metaphase xref: IntAct:EBI-624759 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001363 ! STK6_HUMAN relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001772 ! CKAP5_HUMAN [Term] id: CCO:I0006318 name: mdm2-npm1-4 physical interaction comment: coIP: bait = HDM2, prey = NPM xref: IntAct:EBI-626421 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0006319 name: npm1-tp53-3 physical interaction comment: coIP: bait = npm1; prey =p53 xref: IntAct:EBI-626567 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:I0006320 name: npm1-tp53-4 physical interaction comment: coIP: bait = npm1; prey =p53 xref: IntAct:EBI-626577 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001495 ! NPM_HUMAN [Term] id: CCO:I0006321 name: nek2-nek11-8 phosphorylation comment: Autorepression of NEK2 xref: IntAct:EBI-633321 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001984 ! NEK11_HUMAN [Term] id: CCO:I0006322 name: pb1-arid2-4 physical interaction comment: coIP: bait = baf180; preys = baf200, brg1 xref: IntAct:EBI-637883 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001938 ! PB1_HUMAN relationship: has_participant CCO:B0005414 ! SMCA4_HUMAN relationship: has_participant CCO:B0005497 ! ARID2_HUMAN [Term] id: CCO:I0006323 name: hcfc1-creb3-2 physical interaction comment: GST pull-down to show interaction between hcfc1 and creb3 and that the HBM is necessary for this interaction xref: IntAct:EBI-640484 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005498 ! CREB3_HUMAN [Term] id: CCO:I0006324 name: pten-mast3-3 phosphorylation comment: Phosphorylation of human PTEN by Mast3 xref: IntAct:EBI-696526 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0005499 ! MAST3_HUMAN [Term] id: CCO:I0006326 name: blm-terf1-6 direct interaction comment: ELISA: bait= BLM, prey = TRF1 (TERF1) xref: IntAct:EBI-711022 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0006327 name: pot1-terf2 physical interaction comment: Coimmunoprecipitaion reveals interaction between POT1 ,TERF2 and TINF2 xref: IntAct:EBI-764923 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005503 ! POTE1_HUMAN [Term] id: CCO:I0006328 name: acd-terf2 physical interaction comment: Coimmunoprecipitaion reveals interaction between ACD, POT1 ,TERF2 and TINF2 xref: IntAct:EBI-764927 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005504 ! ACD_HUMAN [Term] id: CCO:I0006329 name: rap1-terf2-2 physical interaction comment: Coimmunoprecipitaion reveals interaction between RAP1, POT1 ,TERF2 and TINF2 xref: IntAct:EBI-764961 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005505 ! TE2IP_HUMAN [Term] id: CCO:I0006330 name: terf2-tinf2 physical interaction comment: Coimmunoprecipitaion reveals interaction between POT1 ,TERF2 and TINF2 xref: IntAct:EBI-764966 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005503 ! POTE1_HUMAN [Term] id: CCO:I0006331 name: rap1-terf2-3 physical interaction comment: Coimmunoprecipitaion reveals interaction between RAP1,TERF2 and TINF2 xref: IntAct:EBI-765072 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005505 ! TE2IP_HUMAN [Term] id: CCO:I0006332 name: ccna2_cdk2-1 direct interaction comment: Crystallisation of Cyclin A2 with CDK2 xref: IntAct:EBI-766822 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006333 name: tgfb1-bapp-1 physical interaction comment: Interaction between transforming growth factor beta 1 and beta amyloid precursor protein detected by crosslinking xref: IntAct:EBI-779649 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001471 ! TGFB1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006334 name: tgfb2-bapp-5 physical interaction comment: Interaction between transforming growth factor beta and beta amyloid precursor protein detected by crosslinking xref: IntAct:EBI-779654 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001687 ! TGFB2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006335 name: sch1-app-3 physical interaction comment: APP-Shc A xref: IntAct:EBI-79022 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006337 name: pola-pola2-6 physical interaction comment: Interaction between POLA, POLA2, PRI1 and PRI2 identified by antibody pulldown. xref: IntAct:EBI-850066 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001503 ! DPOLA_HUMAN relationship: has_participant CCO:B0005507 ! PRI1_HUMAN relationship: has_participant CCO:B0005508 ! PRI2_HUMAN relationship: has_participant CCO:B0005509 ! DPOA2_HUMAN [Term] id: CCO:I0006338 name: pola-pri1-1 physical interaction comment: Interaction between POLA, PRI1 and PRI2 identified by antibody pulldown xref: IntAct:EBI-850113 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001503 ! DPOLA_HUMAN relationship: has_participant CCO:B0005507 ! PRI1_HUMAN relationship: has_participant CCO:B0005508 ! PRI2_HUMAN [Term] id: CCO:I0006341 name: aml2-tle1-1 direct interaction comment: Interaction between human AML2 and TLE1 detected by far western xref: IntAct:EBI-926113 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001766 ! RUNX3_HUMAN relationship: has_participant CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:I0006342 name: bcl10-akt1-3 physical interaction comment: Interaction between BCL10 and Ak1 demonstrated by His-pulldown xref: IntAct:EBI-958953 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001458 ! BCL10_HUMAN relationship: has_participant CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:I0006343 name: bcl10-bcl3-3 physical interaction comment: Interaction between BCL3 and BCL10 demonstrated by His pulldown xref: IntAct:EBI-959037 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001458 ! BCL10_HUMAN relationship: has_participant CCO:B0005513 ! BCL3_HUMAN [Term] id: CCO:I0006344 name: tp53-lap-2 colocalization comment: Colocalisation assay reveals interaction between p53 protein and LAP (truncated CCAAT/enhancer-binding protein beta) protein xref: IntAct:EBI-970362 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005514 ! CEBPB_HUMAN [Term] id: CCO:I0006345 name: pa2g4-npm-1 colocalization xref: IntAct:EBI-983124 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:I0006346 name: pa2g4-npm-2 colocalization xref: IntAct:EBI-983140 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:I0006347 name: ppp2r5d-sgol1-1 physical interaction xref: IntAct:EBI-989265 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001847 ! SGOL1_HUMAN relationship: has_participant CCO:B0005515 ! 2A5D_HUMAN [Term] id: CCO:I0006348 name: ppp2r5a-sgol2-2 physical interaction xref: IntAct:EBI-989272 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001840 ! SGOL2_HUMAN relationship: has_participant CCO:B0005516 ! 2A5A_HUMAN [Term] id: CCO:I0006352 name: pcaf-hif1a-1 physical interaction xref: IntAct:EBI-996456 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:I0006353 name: sgol1-pp2r1b-ppp2r5a physical interaction xref: IntAct:EBI-999355 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001840 ! SGOL2_HUMAN relationship: has_participant CCO:B0005515 ! 2A5D_HUMAN relationship: has_participant CCO:B0005516 ! 2A5A_HUMAN relationship: has_participant CCO:B0005517 ! 2AAB_HUMAN relationship: has_participant CCO:B0005518 ! 2A5E_HUMAN relationship: has_participant CCO:B0005519 ! SET_HUMAN [Term] id: CCO:I0006354 name: map3k8-ruvbl1 physical interaction xref: IntAct:EBI-360717 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005520 ! M3K8_HUMAN [Term] id: CCO:I0006355 name: nfkbia-mcm3 physical interaction xref: IntAct:EBI-360864 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:I0006358 name: ikbke-kif11 physical interaction xref: IntAct:EBI-361305 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001659 ! KIF11_HUMAN relationship: has_participant CCO:B0005523 ! IKKE_HUMAN [Term] id: CCO:I0006359 name: ikbke-ruvbl1 physical interaction xref: IntAct:EBI-361326 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005523 ! IKKE_HUMAN [Term] id: CCO:I0006360 name: ikbkg-smc2l1 physical interaction xref: IntAct:EBI-361431 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001450 ! SMC2_HUMAN relationship: has_participant CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:I0006361 name: ikbkg-msh2 physical interaction xref: IntAct:EBI-361485 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:I0006362 name: ikbkg-mcm7 physical interaction xref: IntAct:EBI-361497 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:I0006363 name: ikbkg-dnch1 physical interaction xref: IntAct:EBI-361536 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001780 ! DYHC1_HUMAN relationship: has_participant CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:I0006364 name: ikbkg-smc4l1 physical interaction xref: IntAct:EBI-361614 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002168 ! SMC4_HUMAN relationship: has_participant CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:I0006365 name: ikbkg-q8ix12 physical interaction xref: IntAct:EBI-361650 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001950 ! CCAR1_HUMAN relationship: has_participant CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:I0006366 name: ikbkg-ppp1cc physical interaction xref: IntAct:EBI-361656 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001596 ! PP1G_HUMAN relationship: has_participant CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:I0006367 name: ikbkg-ppp1cb physical interaction xref: IntAct:EBI-361659 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001689 ! PP1B_HUMAN relationship: has_participant CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:I0006372 name: map3k3-pfdn1 physical interaction xref: IntAct:EBI-362049 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006373 name: map3k3-hspa2 physical interaction xref: IntAct:EBI-362109 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006374 name: map3k3-sugt1 physical interaction xref: IntAct:EBI-362124 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002252 ! SUGT1_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006375 name: map3k3-mcc physical interaction xref: IntAct:EBI-362148 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001549 ! CRCM_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006378 name: map3k3-ruvbl1 physical interaction xref: IntAct:EBI-362211 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006379 name: map3k3-ppp1ca physical interaction xref: IntAct:EBI-362262 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001688 ! PP1A_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006381 name: map3k3-nudc physical interaction xref: IntAct:EBI-362289 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002250 ! NUDC_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006385 name: map3k3-ppp1cc physical interaction xref: IntAct:EBI-362412 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001596 ! PP1G_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006386 name: map3k3-dlg1 physical interaction xref: IntAct:EBI-362427 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001736 ! DLG1_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006389 name: map3k14-ruvbl1 physical interaction xref: IntAct:EBI-363022 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005528 ! M3K14_HUMAN [Term] id: CCO:I0006392 name: map3k14-rara physical interaction xref: IntAct:EBI-363184 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0005528 ! M3K14_HUMAN [Term] id: CCO:I0006393 name: relb-ruvbl1 physical interaction xref: IntAct:EBI-363502 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005529 ! RELB_HUMAN [Term] id: CCO:I0006394 name: ripk2-hspa2 physical interaction xref: IntAct:EBI-363658 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005216 ! RIPK2_HUMAN [Term] id: CCO:I0006396 name: aah62584-cdc37 physical interaction xref: IntAct:EBI-363775 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005530 ! Q6P5Y1_HUMAN [Term] id: CCO:I0006399 name: aah62584-ruvbl1 physical interaction xref: IntAct:EBI-363817 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005530 ! Q6P5Y1_HUMAN [Term] id: CCO:I0006401 name: aah62584-q96sb3 physical interaction xref: IntAct:EBI-363889 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002060 ! NEB2_HUMAN relationship: has_participant CCO:B0005530 ! Q6P5Y1_HUMAN [Term] id: CCO:I0006403 name: aah62584-ppp1cc physical interaction xref: IntAct:EBI-363925 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001596 ! PP1G_HUMAN relationship: has_participant CCO:B0005530 ! Q6P5Y1_HUMAN [Term] id: CCO:I0006404 name: aah62584-ppp1cb physical interaction xref: IntAct:EBI-363928 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001689 ! PP1B_HUMAN relationship: has_participant CCO:B0005530 ! Q6P5Y1_HUMAN [Term] id: CCO:I0006405 name: map3k7ip1-ruvbl1 physical interaction xref: IntAct:EBI-363988 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005531 ! TAB1_HUMAN [Term] id: CCO:I0006407 name: q9nyj8-hspa2 physical interaction xref: IntAct:EBI-364039 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005532 ! TAB2_HUMAN [Term] id: CCO:I0006408 name: q9nyj8-ruvbl1 physical interaction xref: IntAct:EBI-364069 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005532 ! TAB2_HUMAN [Term] id: CCO:I0006410 name: tbk1-ruvbl1 physical interaction xref: IntAct:EBI-364246 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005533 ! TBK1_HUMAN [Term] id: CCO:I0006413 name: tnfrsf1a-ruvbl1 physical interaction xref: IntAct:EBI-364402 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005534 ! TNR1A_HUMAN [Term] id: CCO:I0006415 name: tnfrsf1b-mad2l1 physical interaction xref: IntAct:EBI-364597 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0005535 ! TNR1B_HUMAN [Term] id: CCO:I0006417 name: traf2-ruvbl1 physical interaction xref: IntAct:EBI-365044 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005170 ! TRAF2_HUMAN [Term] id: CCO:I0006419 name: traf6-psmd8 physical interaction xref: IntAct:EBI-365128 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001625 ! PSMD8_HUMAN relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN [Term] id: CCO:I0006420 name: traf6-psmd2 physical interaction xref: IntAct:EBI-365131 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001745 ! PSMD2_HUMAN relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN [Term] id: CCO:I0006422 name: traf6-fancd2 physical interaction xref: IntAct:EBI-365182 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002109 ! FACD2_HUMAN relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN [Term] id: CCO:I0006424 name: nfkbia-mcm7 physical interaction xref: IntAct:EBI-365274 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0005521 ! IKBA_HUMAN [Term] id: CCO:I0006425 name: nfkbib-kpna2 physical interaction xref: IntAct:EBI-365310 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001657 ! IMA2_HUMAN relationship: has_participant CCO:B0005537 ! IKBB_HUMAN [Term] id: CCO:I0006426 name: nfkbib-mcc physical interaction xref: IntAct:EBI-365316 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001549 ! CRCM_HUMAN relationship: has_participant CCO:B0005537 ! IKBB_HUMAN [Term] id: CCO:I0006427 name: map3k14-cdc37 physical interaction xref: IntAct:EBI-365461 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005528 ! M3K14_HUMAN [Term] id: CCO:I0006428 name: traf6-psmd1 physical interaction xref: IntAct:EBI-365491 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002066 ! PSMD1_HUMAN relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN [Term] id: CCO:I0006429 name: nfkbie-ppp6c physical interaction xref: IntAct:EBI-365515 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001353 ! PPP6_HUMAN relationship: has_participant CCO:B0005538 ! IKBE_HUMAN [Term] id: CCO:I0006430 name: chuk-cdc37 physical interaction xref: IntAct:EBI-365524 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005539 ! IKKA_HUMAN [Term] id: CCO:I0006431 name: ikbkb-cdc37 physical interaction xref: IntAct:EBI-365539 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005522 ! IKKB_HUMAN [Term] id: CCO:I0006432 name: ikbke-cdc37 physical interaction xref: IntAct:EBI-365551 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005523 ! IKKE_HUMAN [Term] id: CCO:I0006433 name: ikbkg-cdc37 physical interaction xref: IntAct:EBI-365566 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005524 ! NEMO_HUMAN [Term] id: CCO:I0006434 name: map3k1-cdc37 physical interaction xref: IntAct:EBI-365599 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005525 ! M3K1_HUMAN [Term] id: CCO:I0006436 name: map3k3-cdc37 physical interaction xref: IntAct:EBI-365644 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005526 ! M3K3_HUMAN [Term] id: CCO:I0006437 name: relb-hdac6 physical interaction xref: IntAct:EBI-365713 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002192 ! HDAC6_HUMAN relationship: has_participant CCO:B0005529 ! RELB_HUMAN [Term] id: CCO:I0006438 name: relb-kpna2 physical interaction xref: IntAct:EBI-365716 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001657 ! IMA2_HUMAN relationship: has_participant CCO:B0005529 ! RELB_HUMAN [Term] id: CCO:I0006439 name: tbk1-cdc37 physical interaction xref: IntAct:EBI-365782 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005533 ! TBK1_HUMAN [Term] id: CCO:I0006440 name: tnfrsf1a-fancd2 physical interaction xref: IntAct:EBI-365803 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002109 ! FACD2_HUMAN relationship: has_participant CCO:B0005534 ! TNR1A_HUMAN [Term] id: CCO:I0006442 name: tnfrsf1b-fancd2 physical interaction xref: IntAct:EBI-365812 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002109 ! FACD2_HUMAN relationship: has_participant CCO:B0005535 ! TNR1B_HUMAN [Term] id: CCO:I0006444 name: erbb2-egfr physical interaction xref: IntAct:EBI-1000539 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005540 ! ERBB2_HUMAN [Term] id: CCO:I0006445 name: erbb2-egfr-1 physical interaction xref: IntAct:EBI-1000674 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005540 ! ERBB2_HUMAN [Term] id: CCO:I0006446 name: kntc2_zwint_6 colocalization comment: colocalization of kntc2 and zwint xref: IntAct:EBI-1001660 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0006447 name: zw10_zwint_2 colocalization comment: colocalization of zw10 and zwint xref: IntAct:EBI-1001663 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0006448 name: zwint_mad2l1_1 colocalization comment: colocalization of zwint and mad2l1 xref: IntAct:EBI-1001666 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN [Term] id: CCO:I0006449 name: zwint_bub1b_1 colocalization comment: colocalization of zwint and bubr1 xref: IntAct:EBI-1001670 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001411 ! BUB1B_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0006451 name: ccna2-cdk2-10 direct interaction comment: Structure of human thr160-phospho cdk2-cyclin a complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor xref: IntAct:EBI-1039432 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006452 name: ccna2-cdk2-11 direct interaction comment: Structure of human thr160-phospho cdk2-cyclin a complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor xref: IntAct:EBI-1039443 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006454 name: lkb1-strad-2 physical interaction comment: Interaction between STRAD and LKB1 determined by coimmunoprecipitation xref: IntAct:EBI-1109139 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0001932 ! STRAD_HUMAN [Term] id: CCO:I0006455 name: lkb1-strad-4 physical interaction comment: Interaction between STRAD and LKB1 determined by coimmunoprecipitation xref: IntAct:EBI-1109276 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0001932 ! STRAD_HUMAN [Term] id: CCO:I0006456 name: stk11-strad-5 physical interaction comment: Interaction between STRAD and STK11 (LKB1) determined by coimmunoprecipitation xref: IntAct:EBI-1109318 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0001932 ! STRAD_HUMAN [Term] id: CCO:I0006457 name: ahr-rb1 physical interaction xref: IntAct:EBI-1162624 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001595 ! AHR_HUMAN [Term] id: CCO:I0006458 name: ahr-rb1-1 physical interaction xref: IntAct:EBI-1162695 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001595 ! AHR_HUMAN [Term] id: CCO:I0006459 name: pin1-nek6-1 physical interaction comment: Interaction between PIN1 and NEK6 identified by GST-pulldown xref: IntAct:EBI-1164662 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0002145 ! NEK6_HUMAN [Term] id: CCO:I0006461 name: cops5-cdkn1b physical interaction comment: p27 coimmunoprecipitates with JAB1 in H1299 cell lysates xref: IntAct:EBI-1182075 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0002025 ! CSN5_HUMAN [Term] id: CCO:I0006462 name: cdkn1b-uchl1 physical interaction comment: PGP9.5 coimmunoprecipitates with p27 in H1299 cell lysates xref: IntAct:EBI-1182097 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005541 ! UCHL1_HUMAN [Term] id: CCO:I0006463 name: snip1-myc-1 physical interaction comment: SNIP1 coimmunoprecipitates c-Myc in HEK293 cell lysate xref: IntAct:EBI-1189138 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:I0006465 name: pard3-pard6a-1 physical interaction comment: Interaction between PAR3-PAR6 and PRKCi determined by CoIP. xref: IntAct:EBI-286228 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN [Term] id: CCO:I0006466 name: pard6a-pard3-1 physical interaction comment: Interaction detected by CoIP. xref: IntAct:EBI-286235 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN [Term] id: CCO:I0006467 name: prcki-pard6-1 physical interaction comment: Coimmunoprecipitation of PAR3 PAR6 and PRCKi . xref: IntAct:EBI-286254 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0006471 name: kiaa0387-kiaa0097 physical interaction xref: IntAct:EBI-311507 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001772 ! CKAP5_HUMAN relationship: has_participant CCO:B0005544 ! Q9Y4F8_HUMAN [Term] id: CCO:I0006472 name: kiaa0578-kiaa0865 physical interaction xref: IntAct:EBI-311543 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002267 ! MYO16_HUMAN relationship: has_participant CCO:B0005545 ! NRX1A_HUMAN [Term] id: CCO:I0006473 name: celsr3-bpag1 physical interaction xref: IntAct:EBI-311579 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001443 ! BPAEA_HUMAN relationship: has_participant CCO:B0005546 ! CELR3_HUMAN [Term] id: CCO:I0006475 name: kiaa1206-parc physical interaction xref: IntAct:EBI-311667 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001949 ! PARC_HUMAN relationship: has_participant CCO:B0005547 ! PLXB3_HUMAN [Term] id: CCO:I0006476 name: kiaa1549-bpag1 physical interaction xref: IntAct:EBI-311727 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001443 ! BPAEA_HUMAN relationship: has_participant CCO:B0005548 ! Q9HCM3_HUMAN [Term] id: CCO:I0006479 name: ahr-arnt-3 physical interaction comment: Interaction of AhR/ Arnt with ERAP 140 detected by CoIP. xref: IntAct:EBI-368115 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0005551 ! ARNT_HUMAN relationship: has_participant CCO:B0005552 ! NCOA7_HUMAN [Term] id: CCO:I0006480 name: ahr-arnt-4 physical interaction comment: Interaction of AhR/Arnt with Ncor2 detected by CoIP. xref: IntAct:EBI-368119 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0005551 ! ARNT_HUMAN relationship: has_participant CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:I0006481 name: exosc4-nek1 physical interaction xref: IntAct:EBI-373659 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005554 ! EXOS4_HUMAN [Term] id: CCO:I0006482 name: exosc5-cdk5rap1 physical interaction xref: IntAct:EBI-373707 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002062 ! CK5P1_HUMAN relationship: has_participant CCO:B0005555 ! EXOS5_HUMAN [Term] id: CCO:I0006483 name: exosc8-ches1 physical interaction xref: IntAct:EBI-373722 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001347 ! FOXN3_HUMAN relationship: has_participant CCO:B0005556 ! EXOS8_HUMAN [Term] id: CCO:I0006484 name: exosc3-cdk5rap1 physical interaction xref: IntAct:EBI-373737 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002062 ! CK5P1_HUMAN relationship: has_participant CCO:B0005557 ! EXOS3_HUMAN [Term] id: CCO:I0006485 name: mphosph6-eif3s4 physical interaction xref: IntAct:EBI-373791 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0026269 ! EIF3G_HUMAN [Term] id: CCO:I0006486 name: mphosph6-snx9 physical interaction xref: IntAct:EBI-373797 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005559 ! SNX9_HUMAN [Term] id: CCO:I0006487 name: mphosph6-thop1 physical interaction xref: IntAct:EBI-373800 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0035951 ! THOP1_HUMAN [Term] id: CCO:I0006488 name: mphosph6-q9y448 physical interaction xref: IntAct:EBI-373803 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005561 ! T4AF1_HUMAN [Term] id: CCO:I0006489 name: mphosph6-dncl2a physical interaction xref: IntAct:EBI-373806 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005562 ! DLRB1_HUMAN [Term] id: CCO:I0006490 name: mphosph6-rps20 physical interaction xref: IntAct:EBI-373809 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005563 ! RS20_HUMAN [Term] id: CCO:I0006491 name: mphosph6-dnm2 physical interaction xref: IntAct:EBI-373815 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0002071 ! MPH6_HUMAN [Term] id: CCO:I0006492 name: mphosph6-ded physical interaction xref: IntAct:EBI-373818 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0006493 name: mphosph6-dkfzp762i16 physical interaction xref: IntAct:EBI-373821 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005564 ! RHG18_HUMAN [Term] id: CCO:I0006494 name: skiv2l-cdc2l2 physical interaction xref: IntAct:EBI-373836 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002241 ! CD2L2_HUMAN relationship: has_participant CCO:B0005565 ! SKIV2_HUMAN [Term] id: CCO:I0006495 name: lsm3-xpc physical interaction xref: IntAct:EBI-373914 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001714 ! XPC_HUMAN relationship: has_participant CCO:B0005566 ! LSM3_HUMAN [Term] id: CCO:I0006497 name: lsm8-ask/h37_(hudbf4 physical interaction xref: IntAct:EBI-374010 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002194 ! DBF4A_HUMAN relationship: has_participant CCO:B0005349 ! LSM8_HUMAN [Term] id: CCO:I0006498 name: lsm8-sept5 physical interaction xref: IntAct:EBI-374022 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN relationship: has_participant CCO:B0005349 ! LSM8_HUMAN [Term] id: CCO:I0006499 name: rent1-u315 physical interaction xref: IntAct:EBI-374151 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005568 ! TR112_HUMAN [Term] id: CCO:I0006500 name: rent1-plekhb2 physical interaction xref: IntAct:EBI-374154 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005569 ! PKHB2_HUMAN [Term] id: CCO:I0006501 name: rent1-acas2 physical interaction xref: IntAct:EBI-374160 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005570 ! ACSA_HUMAN [Term] id: CCO:I0006502 name: rent1-bat5 physical interaction xref: IntAct:EBI-374163 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005571 ! BAT5_HUMAN [Term] id: CCO:I0006503 name: rent1-pepp2 physical interaction xref: IntAct:EBI-374166 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005274 ! RHXF2_HUMAN [Term] id: CCO:I0006504 name: rent1-c316g12_3 physical interaction xref: IntAct:EBI-374172 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005572 ! GNPTG_HUMAN [Term] id: CCO:I0006505 name: q9btt4-q71f56-1 physical interaction comment: Interaction detected by MudPIT xref: IntAct:EBI-394793 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001950 ! CCAR1_HUMAN relationship: has_participant CCO:B0002192 ! HDAC6_HUMAN relationship: has_participant CCO:B0005573 ! MED10_HUMAN [Term] id: CCO:I0006506 name: q9nwa0-q71f56-1 physical interaction comment: Interaction detected by MudPIT xref: IntAct:EBI-394834 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001657 ! IMA2_HUMAN relationship: has_participant CCO:B0002192 ! HDAC6_HUMAN relationship: has_participant CCO:B0005475 ! MED9_HUMAN [Term] id: CCO:I0006507 name: q9nx70-q71f56-1 physical interaction comment: Interaction detected by MudPIT xref: IntAct:EBI-394875 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0005574 ! MED29_HUMAN [Term] id: CCO:I0006509 name: fance-fancd2-2 physical interaction comment: Interaction between FANCE and FANCD2 confirmed by his-tag pull down xref: IntAct:EBI-446090 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002109 ! FACD2_HUMAN relationship: has_participant CCO:B0005576 ! FANCE_HUMAN [Term] id: CCO:I0006510 name: ruvbl1-ruvbl2-1 physical interaction comment: Interaction of RUVBL1 and RUVBL2 detected by gel filtration chromatography. xref: IntAct:EBI-449148 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005364 ! RUVB2_HUMAN [Term] id: CCO:I0006513 name: sirt2-hdac6-2 colocalization comment: Interaction between SIRT2 and HDAC6 detected by colocalisation. xref: IntAct:EBI-489368 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0002192 ! HDAC6_HUMAN [Term] id: CCO:I0006514 name: h2afx-nbs1-1 physical interaction xref: IntAct:EBI-494856 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:I0006515 name: nbs1-h2afx-1 physical interaction xref: IntAct:EBI-494873 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:I0006516 name: nbs1-mre11a-1 physical interaction xref: IntAct:EBI-494911 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001641 ! MRE11_HUMAN [Term] id: CCO:I0006517 name: h2afx-mre11a-2 physical interaction xref: IntAct:EBI-494918 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001526 ! H2AX_HUMAN relationship: has_participant CCO:B0001641 ! MRE11_HUMAN [Term] id: CCO:I0006518 name: h2afx-nbs1-2 physical interaction xref: IntAct:EBI-495007 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:I0006523 name: hcfc1-zbtb17-3 physical interaction comment: Y2H to identify the region(s) of hcfc1that is targeted by zbtb17 (Miz1) . xref: IntAct:EBI-621679 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0006524 name: zbtb17-ep300 physical interaction comment: GST pull-down demonstrated that interaction between ep300 and zbtb17 is reduced by hcfc1, c-myc and zbtb17. xref: IntAct:EBI-624124 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0006525 name: zn655-cdk4-2 physical interaction comment: Interaction between ZN655 (VIK) and CDK4 confirmed by coimmunoprecipitation xref: IntAct:EBI-625687 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0005578 ! ZN655_HUMAN [Term] id: CCO:I0006526 name: zn655-cdk4-3 physical interaction comment: Interaction between ZN655 (VIK) and CDK4 confirmed by coimmunoprecipitation xref: IntAct:EBI-625742 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0005578 ! ZN655_HUMAN [Term] id: CCO:I0006527 name: mdm2-npm1-2 physical interaction comment: GST pull down: bait = HDM2, prey = NPM xref: IntAct:EBI-626301 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0006528 name: mdm2-npm1-6 physical interaction comment: coIP: bait = HDM2; preys = NPM1 and p53 xref: IntAct:EBI-626521 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0006529 name: pias1-p53-1 direct interaction comment: GST pull-down: interaction between PIAS1 and P53 xref: IntAct:EBI-629447 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005579 ! PIAS1_HUMAN [Term] id: CCO:I0006530 name: pias1-p53-2 direct interaction comment: GST pull-down: interaction between PIAS1 and P53 xref: IntAct:EBI-629452 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005579 ! PIAS1_HUMAN [Term] id: CCO:I0006531 name: pias1-p53-3 direct interaction comment: GST pull-down: interaction between PIAS1 and P53 xref: IntAct:EBI-629459 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005579 ! PIAS1_HUMAN [Term] id: CCO:I0006532 name: egf-egfr-1 direct interaction comment: Binding of EGF to the EGFR measured by a Scatchard plot xref: IntAct:EBI-640874 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001470 ! EGF_HUMAN [Term] id: CCO:I0006533 name: sept1-aurkb-3 physical interaction comment: Interaction of Septin1 and Aurora-B identified by coimmunoprecipitation xref: IntAct:EBI-693031 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002011 ! SEPT1_HUMAN relationship: has_participant CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:I0006534 name: wrn-terf2-1 physical interaction comment: Pull-down: bait= WRM, prey = TRF2 (TERF2) xref: IntAct:EBI-706633 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006535 name: wrn-p53-1 direct interaction comment: Far-western : Probe = P53, prey = WRN xref: IntAct:EBI-708435 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006536 name: wrn-p53-2 direct interaction comment: Far-western : Probe = P53, prey = WRN xref: IntAct:EBI-708448 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006537 name: hspcb-aars physical interaction comment: In vivo Co-IP: bait= Hsp90 xref: IntAct:EBI-709762 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002066 ! PSMD1_HUMAN relationship: has_participant CCO:B0005580 ! HS90B_HUMAN [Term] id: CCO:I0006538 name: blm-terf2-4 colocalization comment: Colocalization of BLM and TRF2 (TERF2) in Saos2 cells xref: IntAct:EBI-710878 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0006540 name: apc-ctbb1-1 physical interaction comment: Biosensor-Based Micro-Affinity Purification using GST epitope reveals interaction between APC and CTBB1 proteins xref: IntAct:EBI-763296 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0001588 ! MCM5_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN relationship: has_participant CCO:B0005582 ! CAZA2_HUMAN relationship: has_participant CCO:B0005583 ! SC23A_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005585 ! TIF1B_HUMAN [Term] id: CCO:I0006541 name: shc1-app-2 physical interaction comment: APP AID- Shc A xref: IntAct:EBI-78849 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006542 name: shc1-app-1 physical interaction comment: shcA PTB-APP Ccas xref: IntAct:EBI-78927 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006543 name: brca2-shfdg1-2 physical interaction comment: Interaction detected by mammalian two hybrid assay. xref: IntAct:EBI-79842 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0005586 ! DSS1_HUMAN [Term] id: CCO:I0006544 name: ahr-erap_140-1 physical interaction comment: Interaction detected by CoIP xref: IntAct:EBI-80806 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0005552 ! NCOA7_HUMAN [Term] id: CCO:I0006545 name: ahr-arnt-1 physical interaction comment: Interaction of AhR/ Arnt with ERAP 140 detected by CoIP. xref: IntAct:EBI-80826 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0005551 ! ARNT_HUMAN [Term] id: CCO:I0006546 name: ahr-ncor2-1 physical interaction comment: Interaction detected by CoIP xref: IntAct:EBI-80844 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0005553 ! NCOR2_HUMAN [Term] id: CCO:I0006547 name: ahr-arnt-2 physical interaction comment: Interaction of AhR/Arnt with Ncor2 detected by CoIP. xref: IntAct:EBI-80850 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0005551 ! ARNT_HUMAN [Term] id: CCO:I0006548 name: top1-npm1 physical interaction comment: GST pull down assay reveals proteins interacting with the Topoisomerase 1 protein xref: IntAct:EBI-876315 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001622 ! KI67_HUMAN relationship: has_participant CCO:B0005587 ! TOP1_HUMAN [Term] id: CCO:I0006549 name: top1-hnrpc physical interaction comment: GST pull down assay reveals proteins interacting with the Topoisomerase 1 protein xref: IntAct:EBI-876476 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0005587 ! TOP1_HUMAN [Term] id: CCO:I0006551 name: aml2-tle1-2 physical interaction comment: Interaction between human AML2 and TLE1 detected by pulldown xref: IntAct:EBI-926176 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001766 ! RUNX3_HUMAN relationship: has_participant CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:I0006552 name: cdk2-pin1-3 physical interaction comment: Interaction between Cdk2, cyclin E1 and Pin-1 demonstrated by coimmunoprecipitation xref: IntAct:EBI-959207 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001755 ! PIN1_HUMAN [Term] id: CCO:I0006553 name: cdk2-ccne1-3 physical interaction comment: Interaction between Cdk2 and cyclin E1 demonstrated by coimmunoprecipitation xref: IntAct:EBI-959219 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006554 name: tp53-lip physical interaction comment: GST pull down assay reveals interaction between p53 protein and LIP (truncated CCAAT/enhancer-binding protein beta) protein xref: IntAct:EBI-969711 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005514 ! CEBPB_HUMAN [Term] id: CCO:I0006555 name: tp53-cebpb physical interaction comment: Coimmunoprecipitation assay reveals interaction between p53 protein and LIP (truncated CCAAT/enhancer-binding protein beta) protein xref: IntAct:EBI-969787 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005514 ! CEBPB_HUMAN [Term] id: CCO:I0006556 name: mapk1-dusp1-1 physical interaction comment: Interaction between Erk2 and DUSP1 (MKP-1) demonstrated by pulldown xref: IntAct:EBI-975489 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001565 ! MK01_HUMAN relationship: has_participant CCO:B0001566 ! DUS1_HUMAN [Term] id: CCO:I0006557 name: mapk1-dusp1-2 physical interaction comment: Interaction between Erk2 and DUSP1 (MKP-1) demonstrated by pulldown xref: IntAct:EBI-975528 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001565 ! MK01_HUMAN relationship: has_participant CCO:B0001566 ! DUS1_HUMAN [Term] id: CCO:I0006558 name: ppp2r5a-sgol1-1 physical interaction xref: IntAct:EBI-989343 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001847 ! SGOL1_HUMAN relationship: has_participant CCO:B0005516 ! 2A5A_HUMAN [Term] id: CCO:I0006561 name: morf4l2-rb1-1 physical interaction xref: IntAct:EBI-995478 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0005370 ! MO4L2_HUMAN [Term] id: CCO:I0006562 name: tp53-nfya-2 physical interaction xref: IntAct:EBI-1025813 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005382 ! NFYB_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN [Term] id: CCO:I0006563 name: ccna2-cdk2-2 direct interaction comment: Phosphorylated cyclin-dependent kinase-2 bound to cyclin a xref: IntAct:EBI-1026138 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006564 name: tp53-nfya-3 physical interaction xref: IntAct:EBI-1028948 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0006565 name: tp53-nfya-4 physical interaction xref: IntAct:EBI-1029255 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0006566 name: cdk2-cdkn3-1 direct interaction comment: Crystal structure of kinase associated phosphatase (kap) in complex with phospho-cdk2 xref: IntAct:EBI-1031555 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001823 ! CDKN3_HUMAN [Term] id: CCO:I0006567 name: tp53-nfya-7 physical interaction xref: IntAct:EBI-1040888 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN [Term] id: CCO:I0006568 name: cdc5l-akap9 physical interaction xref: IntAct:EBI-1105415 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005588 ! AKAP9_HUMAN [Term] id: CCO:I0006569 name: cdc5l-aof2 physical interaction xref: IntAct:EBI-1105436 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005589 ! LSD1_HUMAN [Term] id: CCO:I0006570 name: dtnbp1-ccna2 physical interaction xref: IntAct:EBI-1105504 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0005258 ! DTBP1_HUMAN [Term] id: CCO:I0006572 name: disc1-cdc5l physical interaction xref: IntAct:EBI-1105515 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006573 name: disc1-cdc5l-1 physical interaction xref: IntAct:EBI-1105520 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006574 name: exoc1-nuf2 physical interaction xref: IntAct:EBI-1105532 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002115 ! NUF2_HUMAN relationship: has_participant CCO:B0005592 ! EXOC1_HUMAN [Term] id: CCO:I0006575 name: disc1-cdk5rap3-1 physical interaction xref: IntAct:EBI-1105543 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002044 ! CK5P3_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006576 name: disc1-cdk5rap3-2 physical interaction xref: IntAct:EBI-1105548 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002044 ! CK5P3_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006577 name: cdc5l-crnkl1 physical interaction xref: IntAct:EBI-1105601 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005593 ! CRNL1_HUMAN [Term] id: CCO:I0006578 name: cep63-cspg6 physical interaction xref: IntAct:EBI-1105611 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005590 ! CEP63_HUMAN [Term] id: CCO:I0006579 name: disc1-dnch1 physical interaction xref: IntAct:EBI-1105668 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001780 ! DYHC1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006580 name: disc1-dnch1-2 physical interaction xref: IntAct:EBI-1105678 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001780 ! DYHC1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006581 name: dtnbp1-bpag1 physical interaction xref: IntAct:EBI-1105748 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001884 ! Q5TBT1_HUMAN relationship: has_participant CCO:B0005258 ! DTBP1_HUMAN [Term] id: CCO:I0006582 name: cdc5l-hook1 physical interaction xref: IntAct:EBI-1105837 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005594 ! HOOK1_HUMAN [Term] id: CCO:I0006583 name: cdc5l-kiaa0182 physical interaction xref: IntAct:EBI-1105872 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005595 ! GSE1_HUMAN [Term] id: CCO:I0006584 name: cdc5l-kiaa0240 physical interaction xref: IntAct:EBI-1105882 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005596 ! K0240_HUMAN [Term] id: CCO:I0006585 name: cdc5l-znf451 physical interaction xref: IntAct:EBI-1105935 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005597 ! Q5VVE9_HUMAN [Term] id: CCO:I0006586 name: cdc5l-kif3c physical interaction xref: IntAct:EBI-1105971 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005598 ! KIF3C_HUMAN [Term] id: CCO:I0006587 name: cdc5l-kif5b physical interaction xref: IntAct:EBI-1105991 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005599 ! KINH_HUMAN [Term] id: CCO:I0006588 name: cdc5l-kiaa1267 physical interaction xref: IntAct:EBI-1106006 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005600 ! K1267_HUMAN [Term] id: CCO:I0006589 name: disc1-macf1 physical interaction xref: IntAct:EBI-1106028 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002237 ! MACF1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006590 name: disc1-macf1-2 physical interaction xref: IntAct:EBI-1106038 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002237 ! MACF1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006591 name: disc1-macf1-3 physical interaction xref: IntAct:EBI-1106043 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002237 ! MACF1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006592 name: disc1-macf1-4 physical interaction xref: IntAct:EBI-1106049 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002237 ! MACF1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006593 name: dtnbp1-macf1 physical interaction xref: IntAct:EBI-1106054 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002237 ! MACF1_HUMAN relationship: has_participant CCO:B0005258 ! DTBP1_HUMAN [Term] id: CCO:I0006594 name: exoc1-macf1 physical interaction xref: IntAct:EBI-1106060 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002237 ! MACF1_HUMAN relationship: has_participant CCO:B0005592 ! EXOC1_HUMAN [Term] id: CCO:I0006595 name: cdc5l-myt1l physical interaction xref: IntAct:EBI-1106107 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005601 ! MYT1L_HUMAN [Term] id: CCO:I0006596 name: disc1-pafah1b1 physical interaction xref: IntAct:EBI-1106185 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001618 ! LIS1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006597 name: disc1-pafah1b1-1 physical interaction xref: IntAct:EBI-1106190 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001618 ! LIS1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006598 name: cdc5l-ppfia2 physical interaction xref: IntAct:EBI-1106216 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005602 ! LIPA2_HUMAN [Term] id: CCO:I0006599 name: cdc5l-ppp1r13b physical interaction xref: IntAct:EBI-1106227 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002046 ! ASPP1_HUMAN relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN [Term] id: CCO:I0006600 name: tnik-ppp1r13b physical interaction xref: IntAct:EBI-1106232 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002046 ! ASPP1_HUMAN relationship: has_participant CCO:B0005603 ! TNIK_HUMAN [Term] id: CCO:I0006601 name: disc1-rad21 physical interaction xref: IntAct:EBI-1106267 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006602 name: disc1-smc2l1 physical interaction xref: IntAct:EBI-1106323 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001450 ! SMC2_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006603 name: cdc5l-sptbn1 physical interaction xref: IntAct:EBI-1106395 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:I0006605 name: cdc5l-ywhaz physical interaction xref: IntAct:EBI-1106576 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0006606 name: cftr-ebp-1 physical interaction xref: IntAct:EBI-1171566 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001745 ! PSMD2_HUMAN relationship: has_participant CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:I0006607 name: snip1-myc physical interaction comment: SNIP1 interacts with c-Myc in a yeast two-hybrid assay xref: IntAct:EBI-1188988 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:I0006608 name: cdk6-cdc37-1 physical interaction comment: Interaction between CDK6 and cdc37 confirmed in vitro xref: IntAct:EBI-295678 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001708 ! CDK6_HUMAN relationship: has_participant CCO:B0001819 ! CDC37_HUMAN [Term] id: CCO:I0006609 name: cdk4-cdc37-1 physical interaction comment: Interaction between cdc37 and CDK4 confirmed in vitro xref: IntAct:EBI-295684 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001819 ! CDC37_HUMAN [Term] id: CCO:I0006610 name: lats1-limk1-3 physical interaction comment: Interaction of human LATS1 and LIMK1 demonstrated by co-ip. xref: IntAct:EBI-444464 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005606 ! LIMK1_HUMAN [Term] id: CCO:I0006611 name: fancd2-fance-1 physical interaction comment: Direct interaction of FANCD2 with FANCE demonstrated by M2H xref: IntAct:EBI-446081 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002109 ! FACD2_HUMAN relationship: has_participant CCO:B0005576 ! FANCE_HUMAN [Term] id: CCO:I0006612 name: p53-sin3a-2 physical interaction comment: Co-IP : bait = sin3a ; prey = P53 xref: IntAct:EBI-493242 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:I0006613 name: cdc6-ubiq-1 physical interaction comment: Ubuiquitination of CDC6 demonstrated by coimmunoprecipitation xref: IntAct:EBI-514878 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001695 ! UBIQ_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN [Term] id: CCO:I0006614 name: cdc2-myt1-1 phosphorylation comment: Phosphorylation of CDC2 by Myt1 xref: IntAct:EBI-515175 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0005607 ! MYT1_HUMAN [Term] id: CCO:I0006615 name: khdrbs1-ptpn6-1 physical interaction comment: Interaction between Sam68 and Shp-1 identified by coimmunoprecipitation xref: IntAct:EBI-518122 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005608 ! PTN6_HUMAN [Term] id: CCO:I0006616 name: khdrbs1-fyn-1 physical interaction comment: Interaction between Sam68 and Fyn identified by coimmunoprecipitation xref: IntAct:EBI-518188 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005609 ! FYN_HUMAN [Term] id: CCO:I0006617 name: khdrbs1-plcg1-1 physical interaction comment: Interaction between Sam68 and Phospholiase C gamma1 identified by coimmunoprecipitation xref: IntAct:EBI-518215 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005610 ! PLCG1_HUMAN [Term] id: CCO:I0006618 name: khdrbs1-grb2-1 physical interaction comment: Interaction between Sam68 and Grb2 identified by coimmunoprecipitation xref: IntAct:EBI-518222 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN [Term] id: CCO:I0006619 name: khdrbs1-cbl-1 physical interaction comment: Interaction between Sam68 and Cbl identified by coimmunoprecipitation xref: IntAct:EBI-518240 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:I0006620 name: khdrbs1-jak3-1 physical interaction comment: Interaction between Sam68 and JAK3 identified by coimmunoprecipitation xref: IntAct:EBI-518289 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005612 ! JAK3_HUMAN [Term] id: CCO:I0006621 name: khdrbs1-grb2-2 physical interaction comment: Interaction between Sam68 and Grb2 identified by coimmunoprecipitation xref: IntAct:EBI-518296 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN [Term] id: CCO:I0006622 name: khdrbs1-jak3-2 physical interaction comment: Interaction between Sam68 and JAK3 identified by coimmunoprecipitation xref: IntAct:EBI-518302 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005612 ! JAK3_HUMAN [Term] id: CCO:I0006623 name: khdrbs1-lck-1 physical interaction comment: Interaction between Sam68 and Lck identified by coimmunoprecipitation xref: IntAct:EBI-518312 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001490 ! LCK_HUMAN relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:I0006624 name: hcfc1-set1-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and set1 xref: IntAct:EBI-540791 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005613 ! SET1A_HUMAN [Term] id: CCO:I0006625 name: hcfc1-ash2l-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and ash2l xref: IntAct:EBI-540828 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005614 ! ASH2L_HUMAN [Term] id: CCO:I0006626 name: hcfc1-wdr5-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and wdr5 xref: IntAct:EBI-540846 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005615 ! WDR5_HUMAN [Term] id: CCO:I0006627 name: pparg-ep300 physical interaction comment: Interaction between PPAR-gamma and p300, detected by pull-down experiments. xref: IntAct:EBI-781445 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005616 ! PPARG_HUMAN [Term] id: CCO:I0006628 name: adam9-mad2l2-2 physical interaction xref: IntAct:EBI-78173 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002204 ! MD2L2_HUMAN relationship: has_participant CCO:B0005372 ! ADAM9_HUMAN [Term] id: CCO:I0006629 name: sch1-app-2 physical interaction comment: shcA-APP in vivo xref: IntAct:EBI-78967 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006630 name: dnmt3b-ubl1-ube2i-1 physical interaction xref: IntAct:EBI-80237 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005423 ! DNM3B_HUMAN [Term] id: CCO:I0006631 name: pard6a-tcp10-2 physical interaction comment: Interaction detected by Y2H. xref: IntAct:EBI-81885 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005617 ! TCP10_HUMAN [Term] id: CCO:I0006632 name: pard6a-cdc42-2 physical interaction comment: Interaction detected by Y2H : bait = par6da, prey = cdc42 xref: IntAct:EBI-81888 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0006633 name: pard6a-tcp10-3 physical interaction comment: Deletion mutants of Par6c were analysed by Y2H for interaction with TC10. xref: IntAct:EBI-81902 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005617 ! TCP10_HUMAN [Term] id: CCO:I0006634 name: pard6a-cdc42-3 physical interaction comment: Deletion mutants of Par6C were analysed by Y2H for interaction with CDC42. xref: IntAct:EBI-81907 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0006640 name: hrasls3-ubqln4 physical interaction xref: IntAct:EBI-954950 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001666 ! HRSL3_HUMAN relationship: has_participant CCO:B0005619 ! UBQL4_HUMAN [Term] id: CCO:I0006642 name: pin1-ubqln4 physical interaction xref: IntAct:EBI-955078 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005619 ! UBQL4_HUMAN [Term] id: CCO:I0006644 name: lzts2-a2bp1 physical interaction xref: IntAct:EBI-955310 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN relationship: has_participant CCO:B0032832 ! FOX1_HUMAN [Term] id: CCO:I0006645 name: ccnk-atxn1 physical interaction xref: IntAct:EBI-955430 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0006646 name: cdk6-atxn1 physical interaction xref: IntAct:EBI-955438 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001708 ! CDK6_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0006647 name: pim2-atxn1 physical interaction xref: IntAct:EBI-955542 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002185 ! PIM2_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0006649 name: mad1l1-coil physical interaction xref: IntAct:EBI-955758 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0005621 ! P80C_HUMAN [Term] id: CCO:I0006650 name: znrd1-gfi1b physical interaction xref: IntAct:EBI-955822 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005622 ! RPA12_HUMAN [Term] id: CCO:I0006651 name: ewsr1-hbp1 physical interaction xref: IntAct:EBI-955830 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001407 ! HBP1_HUMAN relationship: has_participant CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:I0006652 name: ewsr1-hspa2 physical interaction xref: IntAct:EBI-955838 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005225 ! EWS_HUMAN [Term] id: CCO:I0006653 name: hspbp1-hspa2 physical interaction xref: IntAct:EBI-955846 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005199 ! HPBP1_HUMAN [Term] id: CCO:I0006654 name: meox2-hspa2 physical interaction xref: IntAct:EBI-955854 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005623 ! MEOX2_HUMAN [Term] id: CCO:I0006655 name: dvl2-tp53-1 physical interaction xref: IntAct:EBI-956102 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005211 ! DVL2_HUMAN [Term] id: CCO:I0006656 name: mageb18-tp53-1 physical interaction xref: IntAct:EBI-956110 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005185 ! MAGBI_HUMAN [Term] id: CCO:I0006657 name: scamp1-tp53 physical interaction xref: IntAct:EBI-956118 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005624 ! SCAM1_HUMAN [Term] id: CCO:I0006658 name: gfi1b-cops5 physical interaction xref: IntAct:EBI-956654 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0002025 ! CSN5_HUMAN [Term] id: CCO:I0006659 name: gfi1b-ccdc85b physical interaction xref: IntAct:EBI-956662 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005625 ! DIPA_HUMAN [Term] id: CCO:I0006660 name: gfi1b-begain-1 physical interaction xref: IntAct:EBI-956670 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:I0006661 name: gfi1b-ushbp1 physical interaction xref: IntAct:EBI-956678 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005210 ! USBP1_HUMAN [Term] id: CCO:I0006662 name: hbp1-kiaa1279 physical interaction xref: IntAct:EBI-956686 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001407 ! HBP1_HUMAN relationship: has_participant CCO:B0005627 ! K1279_HUMAN [Term] id: CCO:I0006663 name: hspa2-hspbp1-1 physical interaction xref: IntAct:EBI-956702 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005199 ! HPBP1_HUMAN [Term] id: CCO:I0006664 name: npm_alk-gak physical interaction xref: IntAct:EBI-968188 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001364 ! GAK_HUMAN relationship: has_participant CCO:B0001441 ! RAD17_HUMAN relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0001629 ! CENPF_HUMAN relationship: has_participant CCO:B0001771 ! CD2L5_HUMAN relationship: has_participant CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:I0006665 name: npm_alk-cdc14 physical interaction xref: IntAct:EBI-970278 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001629 ! CENPF_HUMAN relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0002092 ! CND3_HUMAN relationship: has_participant CCO:B0005628 ! ALK_HUMAN [Term] id: CCO:I0006667 name: cdc2l1-pak1-ac-vit physical interaction comment: CDC2L1-PAK1 identified by in vitro affinity chromatography xref: IntAct:EBI-1322 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001540 ! CD2L1_HUMAN relationship: has_participant CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:I0006668 name: app-tp53bp2-2 physical interaction comment: APP-TP53BP2 xref: IntAct:EBI-77677 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006669 name: apbb2-app-2 physical interaction comment: APP-FE65L co-ip xref: IntAct:EBI-79299 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002020 ! APBB2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006670 name: brca2-shfdg1-3 physical interaction comment: Interaction detected by coimmunoprecipitation. xref: IntAct:EBI-79847 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0005586 ! DSS1_HUMAN [Term] id: CCO:I0006671 name: shfdg1-brca2-3 physical interaction comment: Interaction detected by coimmunoprecipitation. xref: IntAct:EBI-79852 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0005586 ! DSS1_HUMAN [Term] id: CCO:I0006672 name: rps6ka4-mapk3 physical interaction comment: Interaction of Erk1 and Rsk-B identified by co-immunoprcipitation xref: IntAct:EBI-74011 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001560 ! MK03_HUMAN relationship: has_participant CCO:B0005629 ! KS6A4_HUMAN [Term] id: CCO:I0006673 name: hrmt1l1-rara-1 physical interaction comment: Interaction detected by GST pull down. xref: IntAct:EBI-78595 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0005630 ! ANM2_HUMAN [Term] id: CCO:I0006674 name: incenp-cbx5-1 physical interaction comment: Interaction of truncated INCENP and HP1detected by Y2H. xref: IntAct:EBI-307771 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002154 ! INCE_HUMAN relationship: has_participant CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:I0006676 name: rad51-rad51-2 colocalization comment: Interaction detected by Fluroscence. xref: IntAct:EBI-297250 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0006677 name: grb2-egfr-1 physical interaction comment: Interaction detected by GST pull down. xref: IntAct:EBI-297464 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0001501 ! K2C7_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN [Term] id: CCO:I0006682 name: cul4b-tip120a-1 physical interaction comment: Interaction between CUL4B and TIP120A identified by co-affinity purification xref: IntAct:EBI-456087 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN [Term] id: CCO:I0006683 name: cul4a-tip120a-1 physical interaction comment: Interaction between CUL4A and TIP120A identified by co-affinity purification xref: IntAct:EBI-456098 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006684 name: cul3-tip120a-2 physical interaction comment: Interaction between CUL3A and TIP120A identified by co-affinity purification xref: IntAct:EBI-456121 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001761 ! CUL3_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006685 name: cul1-tip120a-1 physical interaction comment: Interaction between CUL1 and TIP120A identified by co-affinity purification xref: IntAct:EBI-456160 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006686 name: cul2-tip120a-2 physical interaction comment: Interaction between CUL2 and TIP120A identified by co-affinity purification xref: IntAct:EBI-456171 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001760 ! CUL2_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006687 name: cul4b-tip120a-2 physical interaction comment: Interaction between CUL4B and TIP120A identified by co-affinity purification xref: IntAct:EBI-456195 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006688 name: cul1-tip120a-2 physical interaction comment: Interaction between CUL1 and TIP120A identified by coimmunoprecipitation xref: IntAct:EBI-456207 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006689 name: cul2-tip120a-1 physical interaction comment: Interaction between CUL2 and TIP120A identified by co-immunoprecipitation xref: IntAct:EBI-456217 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001760 ! CUL2_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006690 name: cul3-tip120a-1 physical interaction comment: Interaction between CUL3 and TIP120A identified by coimmunoprecipitation xref: IntAct:EBI-456227 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001761 ! CUL3_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006691 name: cul4a-tip120a-2 physical interaction comment: Interaction between CUL4A and TIP120A identified by coimmunoprecipitation xref: IntAct:EBI-456237 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006692 name: cul4b-tip120a-3 physical interaction comment: Interaction between CUL4B and TIP120A identified by coimmunprecipitation xref: IntAct:EBI-456247 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006693 name: cul1-tip120a-3 physical interaction comment: Formation of Skp1/F-box protein complex xref: IntAct:EBI-456255 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN relationship: has_participant CCO:B0005633 ! FBW1A_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006694 name: cul1-tip120a-4 physical interaction comment: Formation of ubiquitin ligase protein complex xref: IntAct:EBI-456271 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006695 name: cul1-skp1-1 physical interaction comment: Formation of skp1/f-box protein complex xref: IntAct:EBI-456324 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006696 name: cul1-skp1-2 physical interaction comment: Formation of skp1/f-box protein complex xref: IntAct:EBI-456337 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005633 ! FBW1A_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006697 name: cul1-skp1-3 physical interaction comment: Interaction between CUL1 and SKP1 demonstrated by co-immunoprecipitation xref: IntAct:EBI-456350 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006698 name: tp53-tbp1 physical interaction comment: Interaction between the C-terminal end of p53 and TBP detected by Western blotting. xref: IntAct:EBI-398460 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005481 ! TBP_HUMAN [Term] id: CCO:I0006699 name: tp53-tbp-2 physical interaction comment: Interaction between p53 and TBP detected by Western blot. xref: IntAct:EBI-398465 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005481 ! TBP_HUMAN [Term] id: CCO:I0006702 name: hif1a-ep300-3 physical interaction comment: Interaction of HIF1A with EP300 confirmed by CoIP. xref: IntAct:EBI-447509 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:I0006703 name: trrap-myc-2 physical interaction comment: Interaction of TRRAP requires N-terminal domains in c-Myc. xref: IntAct:EBI-447565 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN [Term] id: CCO:I0006704 name: akip-stk6-1 physical interaction comment: immunoprecipitation, bait = human AKIP, prey = human Aurora A xref: IntAct:EBI-448670 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001363 ! STK6_HUMAN relationship: has_participant CCO:B0002171 ! AKIP_HUMAN [Term] id: CCO:I0006705 name: plk1-mcm7-3 physical interaction comment: Interaction between PLK1 and MINC7 detected by pull down using purified GST-PLK1 and endogenous MNC7 present in HEK-293T cells lysate xref: IntAct:EBI-476833 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:I0006708 name: sirt2-hdac6-1 physical interaction comment: Interaction between SIRT2 and HDAC6 detected by CoIP. xref: IntAct:EBI-489322 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0002192 ! HDAC6_HUMAN [Term] id: CCO:I0006712 name: khdrbs1-lyn-1 physical interaction comment: Interaction between Sam68 and Lyn identified by coimmunoprecipitation xref: IntAct:EBI-518323 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005457 ! LYN_HUMAN [Term] id: CCO:I0006713 name: crebbp-khdrbs1-9 colocalization comment: Interaction of CBP with Sam68 demonstrated by GST pull-down xref: IntAct:EBI-519704 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:I0006714 name: tbp-taf1-1 physical interaction comment: TAFII-250 binds to TBP, as detected by far-western. xref: IntAct:EBI-520065 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001543 ! TAF1_HUMAN relationship: has_participant CCO:B0005481 ! TBP_HUMAN [Term] id: CCO:I0006715 name: rent1-stau-3 physical interaction xref: IntAct:EBI-536608 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005483 ! STAU1_HUMAN [Term] id: CCO:I0006716 name: rent1-stau-4 physical interaction xref: IntAct:EBI-536615 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005483 ! STAU1_HUMAN [Term] id: CCO:I0006717 name: mapk3-elk1-1 phosphorylation comment: Phosphorylation of ELK1 by MAPK3 (Erk1) xref: IntAct:EBI-959845 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001560 ! MK03_HUMAN relationship: has_participant CCO:B0005637 ! ELK1_HUMAN [Term] id: CCO:I0006718 name: mapk1-elk1-1 phosphorylation comment: Phosphorylation of ELK1 by MAPK31(Erk2) xref: IntAct:EBI-959983 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001565 ! MK01_HUMAN relationship: has_participant CCO:B0005637 ! ELK1_HUMAN [Term] id: CCO:I0006720 name: msh2-msh6-1 physical interaction comment: Interaction between human MSH2 and MSH6 detected by Y2H xref: IntAct:EBI-944708 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:I0006721 name: p300-tfap2a-7 physical interaction comment: Interaction between human p300 and TFAP2A detected by mammalian two-hybrid xref: IntAct:EBI-938489 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0006723 name: disc1-tubg colocalization comment: Colocalisation of DISC1 protein and gamma tubulin protein xref: IntAct:EBI-930597 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001548 ! TBG1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006724 name: p300-tfap2a-2 physical interaction comment: Interaction between human p300 and TFAP2A detected by mammalian two-hybrid xref: IntAct:EBI-937812 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0002091 ! CITE2_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0006725 name: p300-tfap2a-3 physical interaction comment: Interaction between human p300 and TFAP2A detected by mammalian two-hybrid xref: IntAct:EBI-937827 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0006726 name: p300-tfap2a-4 physical interaction comment: Interaction between human p300 and TFAP2A detected by mammalian two-hybrid xref: IntAct:EBI-937855 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0006727 name: p300-tfap2a-5 physical interaction comment: Interaction between human p300 and TFAP2A detected by mammalian two-hybrid xref: IntAct:EBI-937867 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0006728 name: abl1-sorbs-2 physical interaction comment: Interaction between SORB1 and ABL1 demonstrated by coimmunoprecipitation xref: IntAct:EBI-624126 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005641 ! SRBS1_HUMAN [Term] id: CCO:I0006729 name: pb1-arid2-2 physical interaction comment: coIP: bait = baf180; prey = baf200 xref: IntAct:EBI-637836 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001938 ! PB1_HUMAN relationship: has_participant CCO:B0005497 ! ARID2_HUMAN [Term] id: CCO:I0006730 name: nek2-nek11-6 physical interaction comment: Interaction between NEK2A and NEK11 demonstrated by GST-pulldown xref: IntAct:EBI-633287 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001984 ! NEK11_HUMAN [Term] id: CCO:I0006731 name: sept1-aurkb-4 physical interaction comment: Colocalization of Septin1 and Aurora-B identified by colocalization xref: IntAct:EBI-693043 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002011 ! SEPT1_HUMAN relationship: has_participant CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:I0006732 name: actn2-ttn-4 physical interaction comment: Interaction of Titin with alpha Actinin 2 does not depend on Actinin dimer formation, as detected by crosslinking. xref: IntAct:EBI-698651 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005642 ! ACTN2_HUMAN [Term] id: CCO:I0006733 name: ttn-ttn-1 physical interaction comment: Intra-molecular binding of Titin, as detected by yeast two hybrid. xref: IntAct:EBI-681275 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN [Term] id: CCO:I0006737 name: ccnd2-cdk4-1 physical interaction comment: Interaction between cyclin D2 and CDK4 demonstrated by coimmunoprecipitation xref: IntAct:EBI-768365 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001573 ! CCND2_HUMAN [Term] id: CCO:I0006738 name: ccnd2-cdk4-2 physical interaction comment: Interaction between cyclin D3 and CDK4 demonstrated by coimmunoprecipitation xref: IntAct:EBI-768369 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001574 ! CCND3_HUMAN [Term] id: CCO:I0006739 name: hd53-hd53-2 physical interaction comment: Homodimerisation of human D53 detected by Y2H xref: IntAct:EBI-782691 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN [Term] id: CCO:I0006740 name: hd53-hd53-3 physical interaction comment: Interaction between human D53 and human D53 isoform detected by Y2H xref: IntAct:EBI-782699 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0005643 ! O43397_HUMAN [Term] id: CCO:I0006741 name: hd53-hd53-4 physical interaction comment: Interaction between human D53 and partial human D53 detected by Y2H xref: IntAct:EBI-782702 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN [Term] id: CCO:I0006742 name: pml-suv39h1-2 physical interaction comment: Interaction between PML and Myc-SUV39H1 was determined by CoIP xref: IntAct:EBI-870893 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005644 ! Q9BWP7_HUMAN [Term] id: CCO:I0006743 name: ttn-obscn-3 physical interaction xref: IntAct:EBI-966813 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005645 ! OBSCN_HUMAN [Term] id: CCO:I0006745 name: dusp1-ubiq-1 ubiquitination comment: Ubiquitination of DUSP1demonstrated by coimmunoprecipitation xref: IntAct:EBI-975570 is_a: CCO:Y0000026 ! ubiquitination reaction relationship: has_participant CCO:B0001566 ! DUS1_HUMAN relationship: has_participant CCO:B0001695 ! UBIQ_HUMAN [Term] id: CCO:I0006746 name: dusp1-skp2-1 physical interaction comment: Interaction between DUSP1 and SKP2 demonstrated by coimmunoprecipitation xref: IntAct:EBI-975591 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001566 ! DUS1_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN [Term] id: CCO:I0006747 name: dusp1-skp2-2 physical interaction comment: Interaction between DUSP1 and SKP2 demonstrated by coimmunoprecipitation xref: IntAct:EBI-975605 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001566 ! DUS1_HUMAN relationship: has_participant CCO:B0001686 ! CKS1_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN [Term] id: CCO:I0006748 name: brca1-trrap-2 physical interaction comment: Interaction detected by Coip. xref: IntAct:EBI-896489 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0002021 ! RAD50_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN relationship: has_participant CCO:B0005647 ! GCNL2_HUMAN [Term] id: CCO:I0006749 name: brca1-trrap-3 physical interaction comment: Interaction detected by Coip. xref: IntAct:EBI-896498 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0002021 ! RAD50_HUMAN relationship: has_participant CCO:B0005647 ! GCNL2_HUMAN [Term] id: CCO:I0006750 name: zwint_zw10_2 colocalization comment: colocalization of zwint and zw10 by immunofluorescence microscopy xref: IntAct:EBI-1001292 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0006751 name: mad1l1_zw10_1 colocalization comment: colocalization of mad1 and zw10 by immunofluorescence microscopy xref: IntAct:EBI-1001430 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN [Term] id: CCO:I0006752 name: zw10_bub1_1 colocalization comment: colocalization of zw10 and bub1 by immunofluorescence microscopy xref: IntAct:EBI-1001434 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001395 ! BUB1_HUMAN [Term] id: CCO:I0006753 name: zw10_bub1b_2 colocalization comment: colocalization of zw10 and bubr1 by immunofluorescence microscopy xref: IntAct:EBI-1001465 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001411 ! BUB1B_HUMAN [Term] id: CCO:I0006754 name: zw10_dync1l1_1 colocalization comment: colocalization of zw10 and dync1l1 by immunofluorescence microscopy xref: IntAct:EBI-1001469 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0005648 ! DC1I1_HUMAN [Term] id: CCO:I0006755 name: kntc2_zwint_4 colocalization comment: colocalization of kntc2 and zwint xref: IntAct:EBI-1001599 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0006756 name: zw10_zwint_1 colocalization comment: colocalization of zw10 and zwint xref: IntAct:EBI-1001608 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0006757 name: kntc2_zw10_2 colocalization comment: colocalization of kntc2 and zw10 xref: IntAct:EBI-1001614 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN [Term] id: CCO:I0006758 name: sgol1-ppp2ca-1 physical interaction xref: IntAct:EBI-989140 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001697 ! PP2AA_HUMAN relationship: has_participant CCO:B0001847 ! SGOL1_HUMAN [Term] id: CCO:I0006759 name: sgol1-ppm1a-1 physical interaction xref: IntAct:EBI-989168 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001847 ! SGOL1_HUMAN relationship: has_participant CCO:B0005649 ! PPM1A_HUMAN [Term] id: CCO:I0006760 name: sgol1-ppp2r5a-1 physical interaction xref: IntAct:EBI-989173 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001847 ! SGOL1_HUMAN relationship: has_participant CCO:B0005516 ! 2A5A_HUMAN [Term] id: CCO:I0006761 name: sgol2-ppp2ca-1 physical interaction xref: IntAct:EBI-989242 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001697 ! PP2AA_HUMAN relationship: has_participant CCO:B0001840 ! SGOL2_HUMAN [Term] id: CCO:I0006762 name: sgol2-ppm1a-1 physical interaction xref: IntAct:EBI-989247 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001840 ! SGOL2_HUMAN relationship: has_participant CCO:B0005649 ! PPM1A_HUMAN [Term] id: CCO:I0006763 name: usp7-tp53-5 physical interaction xref: IntAct:EBI-997494 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:I0006764 name: kntc2-spbc24-3 physical interaction xref: IntAct:EBI-1000134 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0006765 name: kntc2-spbc25-4 physical interaction xref: IntAct:EBI-1000323 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0006766 name: shoc2-erbb2ip-2 physical interaction xref: IntAct:EBI-994081 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002059 ! LAP2_HUMAN relationship: has_participant CCO:B0005650 ! SHOC2_HUMAN [Term] id: CCO:I0006767 name: skp1a-skp2-1 direct interaction comment: Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex xref: IntAct:EBI-1030257 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006768 name: skp1a-skp2-2 direct interaction comment: Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex xref: IntAct:EBI-1030268 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006769 name: skp1a-skp2-3 direct interaction comment: Insights into scf ubiquitin ligases from the structure of xref: IntAct:EBI-1030279 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006770 name: ccna2-cdk2-3 direct interaction comment: The structure of cdk2/cyclin a in complex with an oxindole inhibitor xref: IntAct:EBI-1030422 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006771 name: lig4-xrcc4-1 direct interaction comment: Crystal structure of a xrcc4-dna ligase iv complex xref: IntAct:EBI-1032322 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001639 ! DNL4_HUMAN relationship: has_participant CCO:B0005651 ! XRCC4_HUMAN [Term] id: CCO:I0006772 name: brca1-esr1 physical interaction xref: IntAct:EBI-1025255 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0006773 name: esr1-brca1-10 physical interaction xref: IntAct:EBI-1025302 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0006774 name: brca1-esr1-2 physical interaction xref: IntAct:EBI-1025311 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0006775 name: esr1-brca1-11 physical interaction xref: IntAct:EBI-1025336 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0006776 name: ran-ranbp1-1 physical interaction comment: Crystal structure of ran-gppnhp-ranbp1-rangap complex xref: IntAct:EBI-1032926 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0005653 ! RANG_HUMAN [Term] id: CCO:I0006777 name: ran-ranbp1-2 physical interaction comment: Crystal structure of ran-gdp-alfx-ranbp1-rangap complex xref: IntAct:EBI-1032940 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0005653 ! RANG_HUMAN [Term] id: CCO:I0006778 name: lkb1-strad-7 phosphorylation comment: Phosphorylation of STRAD by LKB1 xref: IntAct:EBI-1109451 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0001932 ! STRAD_HUMAN [Term] id: CCO:I0006779 name: lkb1-strad-8 phosphorylation comment: Phosphorylation of STRAD by LKB1 xref: IntAct:EBI-1109485 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0001932 ! STRAD_HUMAN [Term] id: CCO:I0006780 name: tp53-fbxo11-2 direct interaction comment: Interaction between p53 and FBX011 identified by pulldown xref: IntAct:EBI-1168039 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005332 ! FBX11_HUMAN [Term] id: CCO:I0006781 name: ctcf-chd8-3 physical interaction xref: IntAct:EBI-1169187 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001630 ! CTCF_HUMAN relationship: has_participant CCO:B0005444 ! CHD8_HUMAN [Term] id: CCO:I0006782 name: ctcf-chd8-4 colocalization xref: IntAct:EBI-1169201 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001630 ! CTCF_HUMAN relationship: has_participant CCO:B0005444 ! CHD8_HUMAN [Term] id: CCO:I0006783 name: rad21-stag2 physical interaction xref: IntAct:EBI-1175754 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN [Term] id: CCO:I0006784 name: myc-snip1 physical interaction comment: SNIP1 coimmunoprecipitates with c-Myc in HEK293 cell lysate xref: IntAct:EBI-1189079 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:I0006785 name: myc-skp2 physical interaction comment: SKP2 coimmunoprecipitates with c-Myc in HEK293 cell lysate xref: IntAct:EBI-1190080 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN [Term] id: CCO:I0006786 name: myc-fbxw7 physical interaction comment: FBW7 coimmunoprecipitates with c-Myc in HEK293 cell lysate xref: IntAct:EBI-1190099 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005654 ! FBXW7_HUMAN [Term] id: CCO:I0006787 name: myc-ep300 physical interaction comment: p300 coimmunoprecipitates with c-Myc in HEK293 cell lysate xref: IntAct:EBI-1190163 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:I0006789 name: uchl1-ube2i physical interaction comment: PGP9.5 interacts with UBC9 in a yeast two-hybrid assay xref: IntAct:EBI-1181901 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005541 ! UCHL1_HUMAN [Term] id: CCO:I0006791 name: kntc2_zwint_1 physical interaction comment: Y2H: bait=kntc2, prey=zwint xref: IntAct:EBI-1001482 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0006792 name: cdk6-cdkn2a-1 direct interaction comment: Mechanism of g1 cyclin dependent kinase inhibition from the structure of the cdk6-p16ink4a tumor suppressor complex xref: IntAct:EBI-1027142 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:I0006793 name: cdk6-cdkn2d-2 direct interaction comment: Mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex xref: IntAct:EBI-1027153 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001675 ! CDN2D_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:I0006795 name: tp53-hdac1 physical interaction xref: IntAct:EBI-1029612 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0006796 name: cul1-rbx1-6 direct interaction comment: Structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex xref: IntAct:EBI-1033288 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN [Term] id: CCO:I0006797 name: cul1-cul1-7 physical interaction comment: Structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex xref: IntAct:EBI-1033299 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0006798 name: ccna2-cdk2-8 direct interaction comment: Structure of human thr160-phospho cdk2-cyclin a complexed with a 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitor xref: IntAct:EBI-1037045 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0006799 name: disc1-cdk5rap3 physical interaction xref: IntAct:EBI-1105538 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002044 ! CK5P3_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006800 name: disc1-dctn1 physical interaction xref: IntAct:EBI-1105616 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001779 ! DCTN1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006801 name: disc1-dnch1-1 physical interaction xref: IntAct:EBI-1105673 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001780 ! DYHC1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006802 name: disc1-macf1-1 physical interaction xref: IntAct:EBI-1106033 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002237 ! MACF1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006803 name: disc1-ppp5c physical interaction xref: IntAct:EBI-1106247 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001662 ! PPP5_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN [Term] id: CCO:I0006806 name: tp53-pias4-3 physical interaction xref: IntAct:EBI-1153708 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005402 ! PIAS4_HUMAN [Term] id: CCO:I0006807 name: h3-caf1 physical interaction xref: IntAct:EBI-1165514 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001742 ! CAF1A_HUMAN relationship: has_participant CCO:B0001743 ! CAF1B_HUMAN relationship: has_participant CCO:B0005221 ! H31_HUMAN [Term] id: CCO:I0006808 name: cul4b-ddb1-2 physical interaction xref: IntAct:EBI-1177650 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005656 ! DTL_HUMAN [Term] id: CCO:I0006809 name: cul4b-tle2 physical interaction xref: IntAct:EBI-1177657 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005657 ! TLE2_HUMAN [Term] id: CCO:I0006810 name: ddb1-ddb2-1 physical interaction xref: IntAct:EBI-1177673 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005658 ! DDB2_HUMAN [Term] id: CCO:I0006811 name: cul4a-ddb2 physical interaction xref: IntAct:EBI-1177680 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0005658 ! DDB2_HUMAN [Term] id: CCO:I0006812 name: cul4a-cul4b physical interaction xref: IntAct:EBI-1177688 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:I0006813 name: cul4a-eed physical interaction xref: IntAct:EBI-1177705 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005659 ! O75530_HUMAN [Term] id: CCO:I0006814 name: cul4a-cul4b-1 physical interaction xref: IntAct:EBI-1177717 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:I0006815 name: cul4a-cul4b-2 physical interaction xref: IntAct:EBI-1177737 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005615 ! WDR5_HUMAN [Term] id: CCO:I0006816 name: cul4a-cul4b-3 physical interaction xref: IntAct:EBI-1177757 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:I0006817 name: l2dtl-cul4b physical interaction xref: IntAct:EBI-1178576 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005656 ! DTL_HUMAN [Term] id: CCO:I0006818 name: tle2-ddb1-1 physical interaction xref: IntAct:EBI-1178596 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005657 ! TLE2_HUMAN [Term] id: CCO:I0006819 name: rbbp5-cul4a physical interaction xref: IntAct:EBI-1178676 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:I0006820 name: hif1a-vhl-1 physical interaction comment: GST-HIF-1 alpha pulls down VHL xref: IntAct:EBI-1179275 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001600 ! VHL_HUMAN relationship: has_participant CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:I0006821 name: brms1-hdac1 physical interaction comment: HDAC1 coimmunoprecipitates with BRMS1 xref: IntAct:EBI-1200240 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0006822 name: brms1-hdac2 physical interaction comment: HDAC2 coimmunoprecipitates with BRMS1 xref: IntAct:EBI-1200256 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:I0006823 name: brms1-hdac4 physical interaction comment: HDAC4 coimmunoprecipitates with BRMS1 xref: IntAct:EBI-1200276 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001679 ! HDAC4_HUMAN relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN [Term] id: CCO:I0006824 name: brms1-hdac5 physical interaction comment: HDAC5 coimmunoprecipitates with BRMS1 xref: IntAct:EBI-1200285 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0002244 ! HDAC5_HUMAN [Term] id: CCO:I0006825 name: brms1-hdac6 physical interaction comment: HDAC6 coimmunoprecipitates with BRMS1 xref: IntAct:EBI-1200294 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0002192 ! HDAC6_HUMAN [Term] id: CCO:I0006826 name: ccne1-cdkn1b-1 physical interaction comment: Interaction between Cyclin E1 and CDKN1B (p27) by coimmunoprecipitation xref: IntAct:EBI-1201858 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0006827 name: ccnd1-cdkn1b-2 physical interaction comment: Interaction between Cyclin D1 and CDKN1B (p27) by coimmunoprecipitation xref: IntAct:EBI-1201861 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0006829 name: ran-xpot-1 physical interaction comment: Interaction of the transport receptors with Ran determined by affinity chromatography. xref: IntAct:EBI-286729 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0005409 ! IMB1_HUMAN relationship: has_participant CCO:B0005661 ! IPO7_HUMAN relationship: has_participant CCO:B0005662 ! XPO2_HUMAN relationship: has_participant CCO:B0005663 ! TNPO1_HUMAN relationship: has_participant CCO:B0005664 ! XPOT_HUMAN relationship: has_participant CCO:B0005665 ! XPO7_HUMAN [Term] id: CCO:I0006830 name: prkci-pard6b-1 physical interaction comment: Interaction detected by GST-pull down. xref: IntAct:EBI-295441 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0006831 name: prkcz-pard6b-1 physical interaction comment: Interaction detected by GST-pull down. xref: IntAct:EBI-295446 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005315 ! KPCZ_HUMAN [Term] id: CCO:I0006832 name: cdc42-pard6a-1 physical interaction comment: Interaction detected by GST pull down : bait =Pard6A, prey = cdc42 xref: IntAct:EBI-295494 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0006833 name: cdc42-pard6b-1 physical interaction comment: Interaction detected by GST-pull down: bait = human par6dA, prey = human cdc42 xref: IntAct:EBI-295499 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0006834 name: cdc42-pard6g-1 physical interaction comment: Interaction detected by GST-pull down : bait =par6Dg, prey = cdc42 xref: IntAct:EBI-295504 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002112 ! PAR6G_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0006835 name: rac1-pard6a-1 physical interaction comment: Interaction detected by GST-pull down. xref: IntAct:EBI-295509 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005337 ! RAC1_HUMAN [Term] id: CCO:I0006836 name: rac1-pard6b-1 physical interaction comment: Interaction detected by GST-pull down. xref: IntAct:EBI-295514 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005337 ! RAC1_HUMAN [Term] id: CCO:I0006837 name: rac1-pard6g-1 physical interaction comment: Interaction detected by GST-pull down. xref: IntAct:EBI-295519 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002112 ! PAR6G_HUMAN relationship: has_participant CCO:B0005337 ! RAC1_HUMAN [Term] id: CCO:I0006838 name: pard6b-rac1-2 physical interaction comment: Formation of the complex detected by GST pull down. xref: IntAct:EBI-295524 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0006839 name: pard6b-cdc42-5 physical interaction comment: Complex formation detected by GST pull down. xref: IntAct:EBI-295530 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0006841 name: brca2-rad51-2 physical interaction comment: Interaction of the BRC repeat with Rad51 determined and consensus sequence determined. xref: IntAct:EBI-297257 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0006842 name: egfr-grb2-1 physical interaction comment: Interaction detected by pull down. xref: IntAct:EBI-298134 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN [Term] id: CCO:I0006843 name: sos1-cd2ap-1 physical interaction comment: Interaction detected by pull down. xref: IntAct:EBI-298166 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002257 ! CD2AP_HUMAN relationship: has_participant CCO:B0005383 ! SOS1_HUMAN [Term] id: CCO:I0006844 name: sos2-cd2ap-1 physical interaction comment: Interaction detected by pull down. xref: IntAct:EBI-298213 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002257 ! CD2AP_HUMAN relationship: has_participant CCO:B0005666 ! SOS2_HUMAN [Term] id: CCO:I0006845 name: tceb1-tceb2-vh1 physical interaction comment: Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function xref: IntAct:EBI-301276 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001600 ! VHL_HUMAN relationship: has_participant CCO:B0005667 ! ELOC_HUMAN relationship: has_participant CCO:B0005668 ! ELOB_HUMAN [Term] id: CCO:I0006848 name: stau-loc84643-1 physical interaction comment: Characterization of Staufen 1 ribonucleoprotein complexes xref: IntAct:EBI-443534 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001963 ! KIF2B_HUMAN relationship: has_participant CCO:B0005483 ! STAU1_HUMAN [Term] id: CCO:I0006849 name: lats1-cdc2-1 physical interaction comment: Interaction between human LATS1 and CDC2 demonstrated by co-immunoprecipitation xref: IntAct:EBI-444321 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0001493 ! CDC2_HUMAN [Term] id: CCO:I0006850 name: lats1-limk1-1 physical interaction comment: Interaction of human LATS1 and LIMK1 demonstrated by co-ip. xref: IntAct:EBI-444398 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005606 ! LIMK1_HUMAN [Term] id: CCO:I0006851 name: lats1-limk1-2 physical interaction comment: Interaction of human LATS1 and LIMK1 demonstrated by co-ip. xref: IntAct:EBI-444450 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005606 ! LIMK1_HUMAN [Term] id: CCO:I0006854 name: cdt1-gmnn-5 physical interaction comment: Interaction between CDT1 and Germinin detected by GST pull down xref: IntAct:EBI-457118 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001432 ! GEMI_HUMAN relationship: has_participant CCO:B0002126 ! CDT1_HUMAN [Term] id: CCO:I0006855 name: plk1-mcm7-1 physical interaction comment: polo-box domain containing kinase coimmunoprecipitate minichromosome maintainance protein MCM7 xref: IntAct:EBI-476782 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:I0006856 name: plk1-mcm2-1 physical interaction comment: polo-box domain containing kinase coimmunoprecipitate minichromosome maintainance protein MCM2 xref: IntAct:EBI-476798 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:I0006857 name: p53-crebbp-6 physical interaction comment: GST-pull down : bait = CBP (CREB binding protein); prey = P53 xref: IntAct:EBI-493370 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:I0006861 name: cdc2-ccnb1-1 physical interaction comment: Interaction of CDK1 and Cyclin B1 by coimmunopreciptiation xref: IntAct:EBI-515191 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001519 ! CCNB1_HUMAN [Term] id: CCO:I0006862 name: cdk4-ccnd1-5 physical interaction comment: co-IP: bait = cdk4, prey = cyclin D1, prey = p21-CIP1 xref: IntAct:EBI-519497 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0006863 name: cul1-skp1-5 physical interaction comment: Coimmunoprecipitaion reveals interaction between the culin1 protein and the S-phase kinase-associated protein 1 xref: IntAct:EBI-600016 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN [Term] id: CCO:I0006864 name: cul1-skp2-2 physical interaction comment: Coimmunoprecipitaion reveals interaction between the culin1 protein and the S-phase kinase-associated protein 2 xref: IntAct:EBI-600023 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN [Term] id: CCO:I0006865 name: cand1-cul1-3 physical interaction comment: Coimmunoprecipitaion reveals interaction between the TIP120A (CAND1) protein and cullin1 protein xref: IntAct:EBI-600785 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0006866 name: cul1-cand1-7 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin1 protein , TIP120A (CAND1) protein and RBX1 protein xref: IntAct:EBI-600789 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN [Term] id: CCO:I0006867 name: cul1-rbx1-5 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin1 protein and RBX1 protein xref: IntAct:EBI-600793 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN [Term] id: CCO:I0006868 name: hcfc1-gabp2b1-2 physical interaction comment: GST pull-down of interaction between hcfc1 and gabp2b1. xref: IntAct:EBI-620481 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0040683 ! GABP1_HUMAN [Term] id: CCO:I0006869 name: hcfc1-zbtb17-2 physical interaction comment: Co-ip (in-vivo) of interaction between hcfc1 and zbtb17 (Miz1) xref: IntAct:EBI-621550 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0006870 name: nek2-nek11-2 colocalization comment: Interaction between NEK2 and NEK11 demonstrated by coimmunofluorescence xref: IntAct:EBI-633213 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001984 ! NEK11_HUMAN [Term] id: CCO:I0006871 name: nek2-nek11-5 physical interaction comment: Interaction between NEK2A and NEK11 demonstrated by coimmunoprecipitation xref: IntAct:EBI-633249 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001984 ! NEK11_HUMAN [Term] id: CCO:I0006872 name: eif2ak1-cdc37-8 physical interaction comment: Interaction between EIF2AK1 (HPI) and cdc37 demonstrated by coimmunoprecipitation xref: IntAct:EBI-640358 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005580 ! HS90B_HUMAN relationship: has_participant CCO:B0005674 ! E2AK1_HUMAN [Term] id: CCO:I0006873 name: tp53-hipk1-2 physical interaction comment: Interacting regions of p53 and HIPK1 identified by Y2H xref: IntAct:EBI-692933 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005675 ! HIPK1_HUMAN [Term] id: CCO:I0006874 name: ttn-actn2-5 physical interaction comment: Interaction of Titin and alpha Actinin 2 binding regions detected by affinity techniques xref: IntAct:EBI-698792 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005642 ! ACTN2_HUMAN [Term] id: CCO:I0006875 name: wrn-terf2-4 direct interaction comment: Pull-down: bait= WRM, prey = TRF2 (TERF2) xref: IntAct:EBI-706693 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006876 name: wrn-terf2-5 direct interaction comment: Pull-down: bait= WRM, prey = TRF2 (TERF2) xref: IntAct:EBI-706703 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006877 name: wrn-terf2-6 direct interaction comment: Pull-down: bait= WRM, prey = TRF2 (TERF2) xref: IntAct:EBI-706714 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006878 name: wrn-terf2-7 direct interaction comment: Pull-down: bait= WRM, prey = TRF2 (TERF2) xref: IntAct:EBI-706726 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006879 name: blm-terf1-7 direct interaction comment: In vitro Co-IP: bait= TRF1 (TERF1) , prey = BLM xref: IntAct:EBI-711045 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0006880 name: blm-terf1-8 direct interaction comment: In vitro Co-IP: bait= TRF1 (TERF1) , prey = BLM helicase fragment xref: IntAct:EBI-711078 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0006881 name: blm-terf2-9 direct interaction comment: In vitro Co-IP: bait= TRF2 (TERF2) , prey = BLM helicase fragment xref: IntAct:EBI-711090 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0006882 name: blm-terf2-10 direct interaction comment: In vitro Co-IP: bait= TRF2 (TERF2) , prey = BLM c-terminus fragment xref: IntAct:EBI-711103 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0006887 name: brca1-trrap-6 physical interaction comment: Interaction detected by sucrose gradient. xref: IntAct:EBI-896611 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN relationship: has_participant CCO:B0005639 ! MSH6_HUMAN relationship: has_participant CCO:B0005647 ! GCNL2_HUMAN [Term] id: CCO:I0006888 name: eif4g2-eif4a1-1 direct interaction comment: Interaction between eIF4G2 and eIF4A1 demonstrated by His-pulldown xref: IntAct:EBI-927940 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001699 ! IF4G2_HUMAN relationship: has_participant CCO:B0005679 ! IF4A1_HUMAN [Term] id: CCO:I0006890 name: cdc73-ctnnb1-4 physical interaction xref: IntAct:EBI-932449 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:I0006891 name: cited2-tfap2a-1 physical interaction comment: Interaction between human CITED2 and TFAP2A detected by far western xref: IntAct:EBI-937763 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002091 ! CITE2_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0006892 name: cited2-tfap2b-1 physical interaction comment: Interaction between human CITED2 and TFAP2B detected by far western xref: IntAct:EBI-937771 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002091 ! CITE2_HUMAN relationship: has_participant CCO:B0005680 ! AP2B_HUMAN [Term] id: CCO:I0006893 name: cited2-tfap2c-1 physical interaction comment: Interaction between human CITED2 and TFAP2C detected by far western xref: IntAct:EBI-937779 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002091 ! CITE2_HUMAN relationship: has_participant CCO:B0005377 ! AP2C_HUMAN [Term] id: CCO:I0006894 name: s100a6-s100a6-1 physical interaction comment: Homodimerisation of human S100A6 detected by Y2H xref: IntAct:EBI-945542 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001494 ! S10A6_HUMAN [Term] id: CCO:I0006895 name: s100a6-s100b-1 physical interaction comment: Interaction between human S100A6 and S100B detected by Y2H xref: IntAct:EBI-945546 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001494 ! S10A6_HUMAN relationship: has_participant CCO:B0005378 ! S100B_HUMAN [Term] id: CCO:I0006896 name: s100b-s100a6-2 physical interaction comment: Interaction between human S100B and S100A6 detected by Y2H xref: IntAct:EBI-945556 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001494 ! S10A6_HUMAN relationship: has_participant CCO:B0005378 ! S100B_HUMAN [Term] id: CCO:I0006897 name: sept5-sept11 physical interaction comment: Yeast 2 hybrid analysis reveals interaction between SEPT5 protein and SEPT11 protein xref: IntAct:EBI-958008 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN relationship: has_participant CCO:B0002169 ! SEP11_HUMAN [Term] id: CCO:I0006898 name: sept5-sept8 physical interaction comment: Yeast 2 hybrid analysis reveals interaction between SEPT5 protein and SEPT8 protein xref: IntAct:EBI-958054 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002015 ! SEPT8_HUMAN relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN [Term] id: CCO:I0006899 name: sept11-sept5 physical interaction comment: Yeast 2 hybrid analysis reveals interaction between SEPT11 protein and SEPT5 protein xref: IntAct:EBI-958078 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN relationship: has_participant CCO:B0002169 ! SEP11_HUMAN [Term] id: CCO:I0006900 name: atr-tp53-1 phosphorylation comment: Phosphorylation of p53 by ATR xref: IntAct:EBI-969043 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001756 ! ATR_HUMAN [Term] id: CCO:I0006901 name: mapk1-dusp1-3 phosphorylation comment: phosphorylation of DUSP1 (MKP-1) by MAPK1 xref: IntAct:EBI-975550 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001565 ! MK01_HUMAN relationship: has_participant CCO:B0001566 ! DUS1_HUMAN [Term] id: CCO:I0006904 name: mbde-suv93h1-1 physical interaction xref: IntAct:EBI-994581 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005510 ! MBD1_HUMAN [Term] id: CCO:I0006905 name: suv93h1-mbde-1 physical interaction xref: IntAct:EBI-994593 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005510 ! MBD1_HUMAN [Term] id: CCO:I0006906 name: suv93h1-mbd1-4 colocalization xref: IntAct:EBI-994708 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005510 ! MBD1_HUMAN [Term] id: CCO:I0006907 name: atr-creb1-1 phosphorylation comment: Phosphorylation of CREB1 by ATR xref: IntAct:EBI-998362 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001756 ! ATR_HUMAN relationship: has_participant CCO:B0005681 ! CREB1_HUMAN [Term] id: CCO:I0006908 name: kntc2-spbc25-3 physical interaction xref: IntAct:EBI-1000294 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0006909 name: cenph_kntc2_2 physical interaction xref: IntAct:EBI-1003762 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0005682 ! CENPH_HUMAN [Term] id: CCO:I0006910 name: cenph_kntc2_4 physical interaction xref: IntAct:EBI-1003789 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0005682 ! CENPH_HUMAN [Term] id: CCO:I0006911 name: dcp1a-rcd8-xrn1 colocalization xref: IntAct:EBI-1006344 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001954 ! XRN1_HUMAN relationship: has_participant CCO:B0005432 ! DCP1A_HUMAN relationship: has_participant CCO:B0005683 ! EDC4_HUMAN [Term] id: CCO:I0006914 name: esr1-brca1-5 direct interaction xref: IntAct:EBI-1024954 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0006915 name: esr1-brca1-7 direct interaction xref: IntAct:EBI-1025098 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0006916 name: raf1-rap1a-1 direct interaction comment: Crystal structure of rap.gmppnp in complex with the ras- binding-domain of c-raf1 kinase (rafrbd). xref: IntAct:EBI-1026035 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001694 ! RAP1A_HUMAN relationship: has_participant CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:I0006917 name: nfya-tp53 physical interaction xref: IntAct:EBI-1031191 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN [Term] id: CCO:I0006918 name: nfya-tp53-1 physical interaction xref: IntAct:EBI-1032019 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN [Term] id: CCO:I0006919 name: tp53-nfya-5 physical interaction xref: IntAct:EBI-1036989 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN [Term] id: CCO:I0006920 name: tp53-nfya-6 physical interaction xref: IntAct:EBI-1040817 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005382 ! NFYB_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN [Term] id: CCO:I0006921 name: nfya-tp53-2 physical interaction xref: IntAct:EBI-1040859 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005382 ! NFYB_HUMAN [Term] id: CCO:I0006922 name: abl1-rin1-1 physical interaction comment: Interaction between Abl1 and Rin1 identified by coimmunoprecipitation xref: IntAct:EBI-1102754 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005385 ! RIN1_HUMAN [Term] id: CCO:I0006923 name: abl1-rin1-2 physical interaction comment: Interaction between Abl1 and Rin1 identified by coimmunoprecipitation xref: IntAct:EBI-1102761 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005385 ! RIN1_HUMAN [Term] id: CCO:I0006926 name: p53-mdm2-2 physical interaction xref: IntAct:EBI-1108409 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0006927 name: stk11-strad-6 colocalization comment: Interaction between STRAD and STK11 (LKB1) determined by coimmunoprecipitation xref: IntAct:EBI-1109785 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0001932 ! STRAD_HUMAN [Term] id: CCO:I0006928 name: hnrpd-ube2i-2 physical interaction xref: IntAct:EBI-1110491 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:I0006930 name: smc2-hp1 colocalization xref: IntAct:EBI-1175572 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001450 ! SMC2_HUMAN relationship: has_participant CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:I0006931 name: cul4b-ddb1 physical interaction xref: IntAct:EBI-1176116 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005511 ! TLE1_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005656 ! DTL_HUMAN relationship: has_participant CCO:B0005657 ! TLE2_HUMAN relationship: has_participant CCO:B0005687 ! GRWD1_HUMAN relationship: has_participant CCO:B0005688 ! WDR82_HUMAN relationship: has_participant CCO:B0005689 ! WDR26_HUMAN relationship: has_participant CCO:B0005690 ! TLE3_HUMAN relationship: has_participant CCO:B0005691 ! SMU1_HUMAN [Term] id: CCO:I0006934 name: snip1-myc-3 physical interaction comment: GST-SNIP1 pulls down c-Myc xref: IntAct:EBI-1189199 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:I0006935 name: myc-snip1-2 physical interaction comment: GST-c-Myc pulls down SNIP1 xref: IntAct:EBI-1189228 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:I0006936 name: brms1-arid4a physical interaction comment: BRMS1 interacts with RBBP1 (ARID4A) in a yeast two-hybrid assay xref: IntAct:EBI-1199917 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005693 ! ARI4A_HUMAN [Term] id: CCO:I0006937 name: brms1-sds3 physical interaction comment: BRMS1 interacts with SDS3 in a yeast two-hybrid assay xref: IntAct:EBI-1199922 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005694 ! SDS3_HUMAN [Term] id: CCO:I0006938 name: brms1-smarce1 physical interaction comment: BRMS1 interacts with BAF57 (SMARCE1) in a yeast two-hybrid assay xref: IntAct:EBI-1199928 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005416 ! SMCE1_HUMAN [Term] id: CCO:I0006939 name: brms1-taf1 physical interaction comment: BRMS1 interacts with CCG1 (TAF1) in a yeast two-hybrid assay xref: IntAct:EBI-1199934 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001543 ! TAF1_HUMAN relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN [Term] id: CCO:I0006940 name: brms1-nmi physical interaction comment: BRMS1 interacts with NMI in a yeast two-hybrid assay xref: IntAct:EBI-1199942 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005695 ! NMI_HUMAN [Term] id: CCO:I0006941 name: brms1-dnajb6 physical interaction comment: BRMS1 interacts with MRJ (DNAJB6) in a yeast two-hybrid assay xref: IntAct:EBI-1199948 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005696 ! DNJB6_HUMAN [Term] id: CCO:I0006942 name: brms1-kpna5 physical interaction comment: BRMS1 interacts with KPNA5 in a yeast two-hybrid assay xref: IntAct:EBI-1200000 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005697 ! IMA5_HUMAN [Term] id: CCO:I0006943 name: brms1-hspa8 physical interaction comment: BRMS1 interacts HSP70 and HSP90alpha in MDA-MB-231 lysates xref: IntAct:EBI-1200006 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005698 ! HS90A_HUMAN relationship: has_participant CCO:B0005699 ! HSP7C_HUMAN [Term] id: CCO:I0006944 name: cdkn1b-lyn-2 phosphorylation comment: Phosphorylation of CDKN1B (p27) by lyn xref: IntAct:EBI-1201690 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005457 ! LYN_HUMAN [Term] id: CCO:I0006945 name: cdkn1b-abl-2 phosphorylation comment: Phosphorylation of CDKN1B (p27) by murine c-Abl xref: IntAct:EBI-1201742 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0006947 name: daxx-pml-2 colocalization comment: Colocalization detected by confocal microscopy. xref: IntAct:EBI-295919 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001570 ! PML_HUMAN relationship: has_participant CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:I0006948 name: brca2-rad51-1 physical interaction comment: Interaction detected by crystallography. xref: IntAct:EBI-297231 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0006950 name: hdac6-hdac11-1 physical interaction comment: Interaction detected by GST pull down. xref: IntAct:EBI-297951 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002192 ! HDAC6_HUMAN relationship: has_participant CCO:B0005701 ! HDA11_HUMAN [Term] id: CCO:I0006951 name: stk4-rassf5-1 physical interaction comment: Interaction of MST1 and NORE1 identified by co-immunoprecipitation xref: IntAct:EBI-367398 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002008 ! RASF5_HUMAN relationship: has_participant CCO:B0005702 ! STK4_HUMAN [Term] id: CCO:I0006953 name: abi1-nckap1-1 physical interaction xref: IntAct:EBI-389836 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005703 ! ABI1_HUMAN [Term] id: CCO:I0006954 name: lats1-zyx-1 physical interaction comment: Interaction betwen human LATS1 and ZYX identified by Y2H xref: IntAct:EBI-444208 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0006955 name: plk1-mcm7-2 physical interaction comment: deletion analysis of PLK1 interacting with MCM7 xref: IntAct:EBI-476813 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:I0006956 name: plk1-mcm3-1 physical interaction comment: deletion analysis of PLK1 interacting with MCM3 xref: IntAct:EBI-476822 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:I0006957 name: plk1-mcm7-4 physical interaction comment: Interaction between endogenous PLK1 and MINC7 xref: IntAct:EBI-476841 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:I0006958 name: sirt2-pcaf-myod1-2 physical interaction comment: Interaction between SIRT2, PCAF, MYOD1 detected by CoIP. xref: IntAct:EBI-489310 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0005705 ! MYOD1_HUMAN [Term] id: CCO:I0006959 name: pkmyt1-cdc2-1 phosphorylation xref: IntAct:EBI-495348 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0002078 ! PMYT1_HUMAN [Term] id: CCO:I0006960 name: mdc1-atm-1 physical interaction xref: IntAct:EBI-495489 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001641 ! MRE11_HUMAN relationship: has_participant CCO:B0001750 ! ATM_HUMAN relationship: has_participant CCO:B0001788 ! MDC1_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0002021 ! RAD50_HUMAN relationship: has_participant CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:I0006961 name: nbs1-mdc1-1 physical interaction xref: IntAct:EBI-495603 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:I0006962 name: nbs1-atm-1 physical interaction xref: IntAct:EBI-495607 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001750 ! ATM_HUMAN relationship: has_participant CCO:B0001788 ! MDC1_HUMAN [Term] id: CCO:I0006963 name: map4k2-mlk3-1 physical interaction comment: Interaction of GCK with MLK3 xref: IntAct:EBI-49968 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001820 ! M3K11_HUMAN relationship: has_participant CCO:B0005706 ! M4K2_HUMAN [Term] id: CCO:I0006965 name: araf-pbk physical interaction comment: Y2H: bait = A-Raf ,prey = TOPK/BPK-MPAKK-like protein kinase cap site form 2 xref: IntAct:EBI-536978 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002045 ! TOPK_HUMAN relationship: has_participant CCO:B0005708 ! ARAF_HUMAN [Term] id: CCO:I0006966 name: gnai1-numa1-1 physical interaction xref: IntAct:EBI-618676 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0005493 ! GNAI1_HUMAN [Term] id: CCO:I0006967 name: gnai1-gpsm2-3 physical interaction xref: IntAct:EBI-618729 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0005492 ! GPSM2_HUMAN relationship: has_participant CCO:B0005493 ! GNAI1_HUMAN [Term] id: CCO:I0006968 name: gpsm2-numa1-1 physical interaction xref: IntAct:EBI-618735 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:I0006969 name: tacc1-tdrd7-8 physical interaction comment: Interaction between TACC1 and TDRD1 (TRAP) confirmed by coimmunopreciptiation xref: IntAct:EBI-624734 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0005496 ! TDRD7_HUMAN [Term] id: CCO:I0006970 name: huew1-tp53-1 physical interaction comment: coIP: bait = arf-bp1/mule, prey = tp53 xref: IntAct:EBI-626167 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:I0006971 name: tp53-huew1-2 physical interaction comment: coIP: bait = tp53, prey = arf-bp1/mule xref: IntAct:EBI-626197 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:I0006972 name: hcfc1-many-3 physical interaction comment: interaction cosedimentation of Hcfc1, Sin3A, Ash2 and Sp1 in high-molecular-weight complexes xref: IntAct:EBI-630079 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:I0006973 name: hcfc1-zf-1 physical interaction comment: Y2H of interaction between hcfc1 and zf xref: IntAct:EBI-632984 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005710 ! ZHANG_HUMAN [Term] id: CCO:I0006974 name: hcfc1-zf-3 physical interaction comment: Mammalian two-hybrid assay of interaction between hcfc1 and zf xref: IntAct:EBI-633091 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005710 ! ZHANG_HUMAN [Term] id: CCO:I0006975 name: nek2-nek11-1 colocalization comment: Interaction between NEK2 and NEK11 demonstrated by coimmunofluorescence xref: IntAct:EBI-633181 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001984 ! NEK11_HUMAN [Term] id: CCO:I0006976 name: nek2-nek11-7 phosphorylation comment: NEK2A phosphorylates NEK11 xref: IntAct:EBI-633306 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001984 ! NEK11_HUMAN [Term] id: CCO:I0006977 name: smarca4-pb1-arid2-2 physical interaction comment: PBAF complex subunits by CoIp xref: IntAct:EBI-638271 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001938 ! PB1_HUMAN relationship: has_participant CCO:B0005414 ! SMCA4_HUMAN relationship: has_participant CCO:B0005415 ! SMRD1_HUMAN relationship: has_participant CCO:B0005416 ! SMCE1_HUMAN relationship: has_participant CCO:B0005417 ! SMRC2_HUMAN [Term] id: CCO:I0006978 name: egfr-pik3c2b-2 physical interaction comment: Interaction of PIK3C2B and EGFR demonstrated by coimmunoprecipitation xref: IntAct:EBI-641198 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005711 ! P3C2B_HUMAN [Term] id: CCO:I0006979 name: egfr-pik3c2b-5 physical interaction comment: Interaction of PIK3C2B and EGFR demonstrated by coimmunoprecipitation xref: IntAct:EBI-641326 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005711 ! P3C2B_HUMAN [Term] id: CCO:I0006980 name: gnl3-p53 physical interaction comment: Coimmunoprecipitaion reveals interaction between the nucleostemin protein and P53 protein xref: IntAct:EBI-641720 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0002103 ! GNL3_HUMAN [Term] id: CCO:I0006981 name: wrn-terf2-2 physical interaction comment: Co-IP: bait = WRM, prey = TRF2 (TERF2) xref: IntAct:EBI-706668 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0006982 name: tcfcl1-ruvbl1 physical interaction comment: Phosphocellulose chromatography reveals complex of TCFCL1, RUVBL1 and HTAT1P proteins xref: IntAct:EBI-777788 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN [Term] id: CCO:I0006983 name: tcfcl1-ruvbl1-1 physical interaction comment: Phosphocellulose chromatography reveals complex of TCFCL1and RUVBL1 proteins xref: IntAct:EBI-777793 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN [Term] id: CCO:I0006984 name: tcfcl1-ruvbl1-2 physical interaction comment: Phosphocellulose chromatography reveals complex of TCFCL1and RUVBL1 proteins xref: IntAct:EBI-777798 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN [Term] id: CCO:I0006985 name: tcfcl1-ruvbl1-3 physical interaction comment: Phosphocellulose chromatography reveals complex of TCFCL1and RUVBL1 proteins xref: IntAct:EBI-777802 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN [Term] id: CCO:I0006986 name: tgfb2-bapp-2 physical interaction comment: Interaction between transforming growth factor beta and beta amyloid precursor protein detected by chromatography xref: IntAct:EBI-779611 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001687 ! TGFB2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006987 name: tgfb2-bapp-3 physical interaction comment: Interaction between transforming growth factor beta and beta amyloid precursor protein detected by co-IP xref: IntAct:EBI-779619 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001687 ! TGFB2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006988 name: adam17-mad2l1-1 physical interaction xref: IntAct:EBI-78212 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0005712 ! ADA17_HUMAN [Term] id: CCO:I0006989 name: adam17-mad2l1-3 physical interaction xref: IntAct:EBI-78246 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0005712 ! ADA17_HUMAN [Term] id: CCO:I0006990 name: p53-pml-1 physical interaction comment: Interaction between human p53 and human PML detected by coIP xref: IntAct:EBI-782798 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001570 ! PML_HUMAN [Term] id: CCO:I0006991 name: hrmt1l2-ilf3-2 methylation comment: Coimmunoprecipitation of components. xref: IntAct:EBI-78793 is_a: CCO:Y0000021 ! methylation reaction relationship: has_participant CCO:B0001734 ! ILF3_HUMAN relationship: has_participant CCO:B0005713 ! ANM1_HUMAN [Term] id: CCO:I0006992 name: apbb2 -app-1 physical interaction comment: APP-APBB2 (FE65L) xref: IntAct:EBI-79291 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002020 ! APBB2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0006995 name: fbxo5-plk1 phosphorylation comment: Interaction between PLK1 and Emi1 is inhibited by Evi5 N terminus. xref: IntAct:EBI-865692 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001663 ! PLK1_HUMAN relationship: has_participant CCO:B0002221 ! FBX5_HUMAN [Term] id: CCO:I0006996 name: fbxo5-plk1-1 phosphorylation comment: Interaction between PLK1 and Emi1 xref: IntAct:EBI-866028 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001663 ! PLK1_HUMAN relationship: has_participant CCO:B0002221 ! FBX5_HUMAN [Term] id: CCO:I0006999 name: cdc73-ctnnb1 physical interaction xref: IntAct:EBI-932234 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:I0007000 name: cdc73-tcf4 physical interaction xref: IntAct:EBI-932378 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005715 ! ITF2_HUMAN [Term] id: CCO:I0007001 name: hras1-rassf5-2 physical interaction xref: IntAct:EBI-960623 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001467 ! RASH_HUMAN relationship: has_participant CCO:B0002008 ! RASF5_HUMAN [Term] id: CCO:I0007002 name: rap1a-itgal-1 physical interaction xref: IntAct:EBI-961074 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001694 ! RAP1A_HUMAN relationship: has_participant CCO:B0002008 ! RASF5_HUMAN [Term] id: CCO:I0007003 name: e2f3-rb physical interaction comment: Pulldown analysis reveals interaction between E2F3 protein and retinoblastoma-associated protein xref: IntAct:EBI-965909 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001713 ! E2F1_HUMAN [Term] id: CCO:I0007004 name: ttn-obscn-1 physical interaction xref: IntAct:EBI-966774 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005645 ! OBSCN_HUMAN [Term] id: CCO:I0007005 name: myc-zbtb17-1 physical interaction xref: IntAct:EBI-975455 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0007006 name: myc-zbtb17-2 physical interaction xref: IntAct:EBI-975466 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0007007 name: myc-max physical interaction xref: IntAct:EBI-975474 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005336 ! MAX_HUMAN [Term] id: CCO:I0007008 name: e2f3-rb-1 physical interaction comment: Pulldown analysis reveals interaction between E2F3 protein and retinoblastoma-associated protein xref: IntAct:EBI-987168 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001713 ! E2F1_HUMAN [Term] id: CCO:I0007009 name: e2f3-rb-2 physical interaction comment: Pulldown analysis reveals interaction between E2F3 protein and retinoblastoma-associated protein xref: IntAct:EBI-987184 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001713 ! E2F1_HUMAN [Term] id: CCO:I0007010 name: brca2-rad51-9 physical interaction comment: Interaction between BRCA2 and RAD51 determined by GST-pulldown xref: IntAct:EBI-987396 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007012 name: smc1-mcm7-4 direct interaction comment: Interaction between human Smc1 and MCM7 detected by pulldown xref: IntAct:EBI-1004745 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0007013 name: smc1-mcm7-5 direct interaction comment: Interaction between human Smc1 and MCM7 detected by pulldown xref: IntAct:EBI-1004758 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0007014 name: upf1-dcp1a physical interaction xref: IntAct:EBI-1006512 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005432 ! DCP1A_HUMAN [Term] id: CCO:I0007015 name: upf1-dcp2 physical interaction xref: IntAct:EBI-1006558 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005433 ! DCP2_HUMAN [Term] id: CCO:I0007016 name: upf1-rcd8 physical interaction xref: IntAct:EBI-1006676 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005432 ! DCP1A_HUMAN relationship: has_participant CCO:B0005683 ! EDC4_HUMAN relationship: has_participant CCO:B0005717 ! EDC3_HUMAN [Term] id: CCO:I0007017 name: brca1-esr1-4 direct interaction xref: IntAct:EBI-1024926 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0007018 name: brca1-esr1-5 direct interaction xref: IntAct:EBI-1025157 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0007019 name: acaca-brca1-1 physical interaction xref: IntAct:EBI-1025400 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:I0007021 name: stk6-tpx2-1 direct interaction comment: Structure of aurora-a 122-403, phosphorylated on thr287, thr288 and bound to tpx2 1-43 xref: IntAct:EBI-1037348 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001363 ! STK6_HUMAN relationship: has_participant CCO:B0002227 ! TPX2_HUMAN [Term] id: CCO:I0007022 name: appbp1-nedd8-1 physical interaction comment: Appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex xref: IntAct:EBI-1037683 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001758 ! ULA1_HUMAN relationship: has_participant CCO:B0001989 ! UBA3_HUMAN relationship: has_participant CCO:B0005331 ! NEDD8_HUMAN [Term] id: CCO:I0007023 name: appbp1-nedd8-2 physical interaction comment: Appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex with atp xref: IntAct:EBI-1037697 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001758 ! ULA1_HUMAN relationship: has_participant CCO:B0001989 ! UBA3_HUMAN relationship: has_participant CCO:B0005331 ! NEDD8_HUMAN [Term] id: CCO:I0007024 name: apc-ctnnb1-3 direct interaction comment: Beta-catenin in complex with a phosphorylated apc 20aa repeat fragment xref: IntAct:EBI-1040010 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:I0007025 name: tacc1-yeats4-1 physical interaction xref: IntAct:EBI-1151284 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001451 ! YETS4_HUMAN [Term] id: CCO:I0007026 name: tacc1-yeats4-2 physical interaction xref: IntAct:EBI-1151300 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001451 ! YETS4_HUMAN [Term] id: CCO:I0007027 name: tp53-pias4-2 physical interaction xref: IntAct:EBI-1153677 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005402 ! PIAS4_HUMAN [Term] id: CCO:I0007028 name: msh2-msh3 physical interaction comment: GST-MSH2 pull down of MSH3 xref: IntAct:EBI-1164225 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005720 ! MSH3_HUMAN [Term] id: CCO:I0007029 name: msh3-msh2-1 physical interaction comment: GST-MSH3 pull down of MSH2 xref: IntAct:EBI-1164243 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005720 ! MSH3_HUMAN [Term] id: CCO:I0007030 name: msh2-msh6 physical interaction comment: GST-MSH2 pull down of MSH6 xref: IntAct:EBI-1164258 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:I0007031 name: msh6-msh2 physical interaction comment: GST-MSH6 pull down of MSH2 xref: IntAct:EBI-1164270 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:I0007032 name: msh2-msh2 physical interaction comment: MSH2 homodimerisation xref: IntAct:EBI-1164319 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN [Term] id: CCO:I0007033 name: msh3-msh2-2 physical interaction comment: GST-MSH3 pull down of MSH2 xref: IntAct:EBI-1164887 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005720 ! MSH3_HUMAN [Term] id: CCO:I0007034 name: msh6-msh2-1 physical interaction comment: GST-MSH6 pull down of MSH2 xref: IntAct:EBI-1164907 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:I0007035 name: msh3-msh2-3 physical interaction comment: GST-MSH3 pull down of MSH2 xref: IntAct:EBI-1164925 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005720 ! MSH3_HUMAN [Term] id: CCO:I0007036 name: wapl-cspg6 physical interaction xref: IntAct:EBI-1175094 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0002004 ! STAG1_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:I0007037 name: wapl-cspg6-3 physical interaction xref: IntAct:EBI-1175276 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0002004 ! STAG1_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:I0007038 name: smc2l1-smc4l1 physical interaction xref: IntAct:EBI-1175303 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001450 ! SMC2_HUMAN relationship: has_participant CCO:B0002168 ! SMC4_HUMAN [Term] id: CCO:I0007039 name: wapl-cspg6-1 physical interaction xref: IntAct:EBI-1175624 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001829 ! PDS5A_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:I0007040 name: wapl-cspg6-2 physical interaction xref: IntAct:EBI-1175636 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:I0007041 name: chek2-aatf physical interaction comment: Che-1 coimmunoprecipitates with Chk2 xref: IntAct:EBI-1180881 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001459 ! CHK2_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0007044 name: cdn1b-cops5 colocalization comment: p27 colocalizes with JAB1 in H1299 cells xref: IntAct:EBI-1182050 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0002025 ! CSN5_HUMAN [Term] id: CCO:I0007045 name: cdn1b-uchl1 colocalization comment: p27 colocalizes with PGP9.5 in H1299 cells xref: IntAct:EBI-1182061 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005541 ! UCHL1_HUMAN [Term] id: CCO:I0007051 name: mit1a-ef1-fila physical interaction xref: IntAct:EBI-1188258 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001694 ! RAP1A_HUMAN relationship: has_participant CCO:B0005723 ! MTR1A_HUMAN [Term] id: CCO:I0007052 name: mit1b-ef1-fila-1 physical interaction xref: IntAct:EBI-1188355 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001375 ! PPM1G_HUMAN relationship: has_participant CCO:B0005724 ! MTR1B_HUMAN [Term] id: CCO:I0007057 name: cdkn1b-cdk2-2 physical interaction comment: interaction between CDKN1B, CDK2 and CCNA2 demonstrated by SPR xref: IntAct:EBI-1201786 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007058 name: cdkn1b-cdk2-3 direct interaction comment: interaction between CDKN1B and CDK2 demonstrated by SPR xref: IntAct:EBI-1201819 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007059 name: cdkn1b-ccna1-1 direct interaction comment: interaction between CDKN1B and CCNA2 demonstrated by SPR xref: IntAct:EBI-1201829 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007060 name: apbb1-aplp2-1 physical interaction comment: Fe65-APLP2 interaction xref: IntAct:EBI-286397 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0005374 ! APLP2_HUMAN [Term] id: CCO:I0007061 name: apbb1-app physical interaction comment: FE65-APP xref: IntAct:EBI-286468 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007062 name: pard6b-prkci-2 physical interaction comment: interaction detected by CoIP. xref: IntAct:EBI-295452 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN relationship: has_participant CCO:B0005315 ! KPCZ_HUMAN [Term] id: CCO:I0007063 name: rac1-pard6b-2 physical interaction comment: Interaction detected by CoIP. xref: IntAct:EBI-295537 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005337 ! RAC1_HUMAN [Term] id: CCO:I0007064 name: cdc42-pard6b-2 physical interaction comment: Complex detected by CoIP: bait = cdc42, preys = PKC iota, pard6B xref: IntAct:EBI-295543 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0007065 name: pml-daxx-1 physical interaction comment: Interaction detected by Y2H. xref: IntAct:EBI-295906 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001570 ! PML_HUMAN relationship: has_participant CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:I0007066 name: daxx-pml-1 physical interaction comment: Interaction detected in vivo by CoIP. xref: IntAct:EBI-295911 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001570 ! PML_HUMAN relationship: has_participant CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:I0007067 name: tubg-mark4-1 physical interaction comment: MARK4 interacts with alpha, beta and gamma-tubulin detected by TAP. xref: IntAct:EBI-351090 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001548 ! TBG1_HUMAN relationship: has_participant CCO:B0005344 ! MARK4_HUMAN [Term] id: CCO:I0007068 name: lrpprc-eif3s8-1 physical interaction comment: Interaction detected by comigration. xref: IntAct:EBI-353790 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001479 ! ANXA1_HUMAN relationship: has_participant CCO:B0001490 ! LCK_HUMAN relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001591 ! PHB_HUMAN relationship: has_participant CCO:B0001691 ! RS4X_HUMAN relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0005409 ! IMB1_HUMAN relationship: has_participant CCO:B0005458 ! G3P_HUMAN relationship: has_participant CCO:B0005580 ! HS90B_HUMAN relationship: has_participant CCO:B0005663 ! TNPO1_HUMAN relationship: has_participant CCO:B0005686 ! HNRPD_HUMAN relationship: has_participant CCO:B0005698 ! HS90A_HUMAN relationship: has_participant CCO:B0005699 ! HSP7C_HUMAN relationship: has_participant CCO:B0005725 ! ROA2_HUMAN relationship: has_participant CCO:B0005726 ! RS24_HUMAN relationship: has_participant CCO:B0005727 ! TBB5_HUMAN relationship: has_participant CCO:B0005728 ! IF4A2_HUMAN relationship: has_participant CCO:B0005729 ! DDX5_HUMAN relationship: has_participant CCO:B0005730 ! CH60_HUMAN relationship: has_participant CCO:B0005731 ! ANXA6_HUMAN relationship: has_participant CCO:B0005732 ! HNRH1_HUMAN relationship: has_participant CCO:B0005733 ! NUCL_HUMAN relationship: has_participant CCO:B0005734 ! RS8_HUMAN relationship: has_participant CCO:B0005736 ! ANXA2_HUMAN relationship: has_participant CCO:B0005737 ! VIME_HUMAN relationship: has_participant CCO:B0005738 ! VDAC3_HUMAN relationship: has_participant CCO:B0005739 ! GBLP_HUMAN relationship: has_participant CCO:B0005740 ! CD4_HUMAN relationship: has_participant CCO:B0005741 ! RL18_HUMAN relationship: has_participant CCO:B0005742 ! YBOX1_HUMAN relationship: has_participant CCO:B0005743 ! MYL6_HUMAN relationship: has_participant CCO:B0005744 ! RS19_HUMAN relationship: has_participant CCO:B0005746 ! RL7_HUMAN relationship: has_participant CCO:B0005748 ! RS13_HUMAN relationship: has_participant CCO:B0005749 ! RS10_HUMAN relationship: has_participant CCO:B0005750 ! RS9_HUMAN relationship: has_participant CCO:B0005751 ! RL22_HUMAN relationship: has_participant CCO:B0005752 ! EF1B_HUMAN relationship: has_participant CCO:B0005753 ! SYFB_HUMAN relationship: has_participant CCO:B0005754 ! GNAI2_HUMAN relationship: has_participant CCO:B0005755 ! LPPRC_HUMAN relationship: has_participant CCO:B0005756 ! DHRS2_HUMAN relationship: has_participant CCO:B0005758 ! RS7_HUMAN relationship: has_participant CCO:B0005759 ! MLRM_HUMAN relationship: has_participant CCO:B0005760 ! NEP_HUMAN relationship: has_participant CCO:B0005761 ! RL7A_HUMAN relationship: has_participant CCO:B0005762 ! RLA0_HUMAN relationship: has_participant CCO:B0005763 ! RS18_HUMAN relationship: has_participant CCO:B0005765 ! VDAC1_HUMAN relationship: has_participant CCO:B0005767 ! RS12_HUMAN relationship: has_participant CCO:B0005768 ! RS3A_HUMAN relationship: has_participant CCO:B0005769 ! SSRP1_HUMAN relationship: has_participant CCO:B0005770 ! RLA1_HUMAN relationship: has_participant CCO:B0005771 ! H2B1C_HUMAN relationship: has_participant CCO:B0005772 ! TBA1A_HUMAN relationship: has_participant CCO:B0005773 ! DDX3X_HUMAN relationship: has_participant CCO:B0005774 ! ROA1_HUMAN relationship: has_participant CCO:B0005775 ! ACTB_HUMAN relationship: has_participant CCO:B0005776 ! RSSA_HUMAN relationship: has_participant CCO:B0005777 ! VDAC2_HUMAN relationship: has_participant CCO:B0005778 ! ATPA_HUMAN relationship: has_participant CCO:B0005779 ! ENOA_HUMAN relationship: has_participant CCO:B0026270 ! EIF3D_HUMAN relationship: has_participant CCO:B0026271 ! EIF3C_HUMAN relationship: has_participant CCO:B0026272 ! EIF3E_HUMAN relationship: has_participant CCO:B0026273 ! EIF3I_HUMAN relationship: has_participant CCO:B0026274 ! EIF3K_HUMAN relationship: has_participant CCO:B0026275 ! EIF3B_HUMAN [Term] id: CCO:I0007069 name: abi1-abl1-2 physical interaction xref: IntAct:EBI-375643 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005703 ! ABI1_HUMAN [Term] id: CCO:I0007072 name: c20orf20-epc1-2 physical interaction comment: Interaction detected by Anti-FLAG coimmunoprecipitation. xref: IntAct:EBI-399156 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002217 ! ING1_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005360 ! MRGBP_HUMAN [Term] id: CCO:I0007073 name: fancd2-brca2-1 physical interaction comment: Interaction between FANCD2 and BRCA2 detected in y2H xref: IntAct:EBI-446104 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0002109 ! FACD2_HUMAN [Term] id: CCO:I0007076 name: trrap-myc-1 physical interaction comment: TRRAP interacts with c-Myc, as detected by affinity purification. xref: IntAct:EBI-447560 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN [Term] id: CCO:I0007077 name: akip-stk6-2 physical interaction comment: immunoprecipitation, prey = human AKIP, bait = human Aurora A xref: IntAct:EBI-448676 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001363 ! STK6_HUMAN relationship: has_participant CCO:B0002171 ! AKIP_HUMAN [Term] id: CCO:I0007078 name: bard1-git1 physical interaction xref: IntAct:EBI-473469 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:I0007079 name: bard1-hbo1 physical interaction xref: IntAct:EBI-473535 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:I0007080 name: bard1-kiaa1377 physical interaction xref: IntAct:EBI-473546 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0007082 name: bard1-tcerg1 physical interaction xref: IntAct:EBI-473612 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0005396 ! TCRG1_HUMAN [Term] id: CCO:I0007083 name: p53-crebbp-2 physical interaction comment: GST-pull down : bait = CBP (CREB binding protein); prey = P53 xref: IntAct:EBI-493319 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:I0007084 name: p53-crebbp-3 physical interaction comment: GST-pull down : bait = P53 ; prey = CBP (CREB binding protein) xref: IntAct:EBI-493328 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:I0007085 name: p53-crebbp-4 physical interaction comment: GST-pull down : bait = CBP (CREB binding protein) CBP3 domain; prey = P53 xref: IntAct:EBI-493344 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:I0007086 name: p53-crebbp-5 physical interaction comment: GST-pull down : bait = CBP (CREB binding protein); CBP2 domain; prey = P53 xref: IntAct:EBI-493355 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:I0007087 name: pkmyt1-cdc2-2 phosphorylation xref: IntAct:EBI-495361 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0002078 ! PMYT1_HUMAN [Term] id: CCO:I0007088 name: khdrbs1-fyn-2 physical interaction comment: Interaction between Sam68 and Fyn identified by coimmunoprecipitation xref: IntAct:EBI-518195 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005609 ! FYN_HUMAN [Term] id: CCO:I0007089 name: khdrbs1-fyn-3 physical interaction comment: Interaction between Sam68 and Fyn identified by coimmunoprecipitation xref: IntAct:EBI-518204 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005609 ! FYN_HUMAN [Term] id: CCO:I0007090 name: cdk4-ccnd1-3 physical interaction comment: in vitro co-IP: bait = cyclin D1, prey = cdk4 xref: IntAct:EBI-519398 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN [Term] id: CCO:I0007091 name: cdkn1a-ccnd1-1 physical interaction comment: in vitro co-IP: bait = cyclin D1, prey = p21-CIP1 xref: IntAct:EBI-519422 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0007092 name: cdkn1b-ccnd1-2 physical interaction comment: in vitro co-IP: bait = cyclin D1, prey = p27-KIP xref: IntAct:EBI-519440 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007094 name: hcfc1-ogt-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and ogt xref: IntAct:EBI-539854 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005806 ! OGT1_HUMAN [Term] id: CCO:I0007095 name: hcfc1-sin3a-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and sin3a xref: IntAct:EBI-540456 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:I0007096 name: hcfc1-sin3b-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and sin3b xref: IntAct:EBI-540474 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005807 ! SIN3B_HUMAN [Term] id: CCO:I0007097 name: hcfc1-sds3-1 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 and sds3 xref: IntAct:EBI-540503 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005694 ! SDS3_HUMAN [Term] id: CCO:I0007098 name: hcfc1-hcfc1-1 physical interaction comment: Immunoblot (co-ip) : overexpressed N-terminus hcfc1 interacts with endogenous hcfc1 c-terminus. xref: IntAct:EBI-540520 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN [Term] id: CCO:I0007099 name: mdm2-p53-1 direct interaction comment: Interaction between MDM2 and P53 demonstrated by X-ray crystallography xref: IntAct:EBI-541124 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0007103 name: cul2-cand1 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin2 protein and the TIP120A (CAND1) protein xref: IntAct:EBI-595242 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001760 ! CUL2_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0007104 name: cul4a-cand1 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin4a protein and the TIP120A (CAND1) protein xref: IntAct:EBI-595246 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0007105 name: cul1-skp2 physical interaction comment: Coimmunoprecipitaion reveals interaction between the culin1 protein and the S-phase kinase-associated protein 2 xref: IntAct:EBI-595254 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN [Term] id: CCO:I0007106 name: cul1-cand1-1 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin1 protein and the TIP120A (CAND1) protein xref: IntAct:EBI-595260 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0007107 name: cand1-cul1 physical interaction comment: Coimmunoprecipitaion reveals interaction between the TIP120A (CAND1) protein and cullin1 protein xref: IntAct:EBI-595265 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0007108 name: cand1-cul1-1 physical interaction comment: Coimmunoprecipitaion reveals interaction between the TIP120A (CAND1) protein and cullin1 protein xref: IntAct:EBI-595273 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0007109 name: cul1-cand1-2 physical interaction comment: Coimmunoprecipitaion reveals interaction between the cullin1 protein, TIP120A (CAND1) protein and the RING-box protein 1 xref: IntAct:EBI-595277 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN [Term] id: CCO:I0007110 name: cul1-skp1 physical interaction comment: Coimmunoprecipitaion reveals interaction between the culin1 protein and the S-phase kinase-associated protein 1 xref: IntAct:EBI-595337 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN [Term] id: CCO:I0007111 name: cul1-skp1-4 physical interaction comment: Coimmunoprecipitaion reveals interaction between the culin1 protein and the S-phase kinase-associated protein 1 xref: IntAct:EBI-597791 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN [Term] id: CCO:I0007112 name: cul1-skp2-1 physical interaction comment: Coimmunoprecipitaion reveals interaction between the culin1 protein and the S-phase kinase-associated protein 2 xref: IntAct:EBI-597796 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN [Term] id: CCO:I0007113 name: cand1-cul1-4 physical interaction comment: Coimmunoprecipitaion reveals interaction between the TIP120A (CAND1) protein and cullin1 protein xref: IntAct:EBI-597847 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0007114 name: cul1-cand1-8 physical interaction comment: Coimmunoprecipitaion reveals interaction between the TIP120A (CAND1) protein and cullin1 protein xref: IntAct:EBI-597852 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN [Term] id: CCO:I0007115 name: hcfc1-zbtb17-4 physical interaction comment: GST pull-down to identify which region(s) of zbtb17 (Miz1) are required for interaction with hcfc1. xref: IntAct:EBI-621696 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0007116 name: hcfc1-zbtb17-5 physical interaction comment: GST pull-down to identify which region(s) of zbtb17 (Miz1) are required for interaction with hcfc1. xref: IntAct:EBI-621710 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0007117 name: hcfc1-zbtb17-6 physical interaction comment: GST pull-down to identify which region(s) of zbtb17 (Miz1) are required for interaction with hcfc1. xref: IntAct:EBI-621722 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0007118 name: hcfc1-zbtb17-7 physical interaction comment: GST pull-down to identify which region(s) of zbtb17 (Miz1) are required for interaction with hcfc1. xref: IntAct:EBI-621733 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0007119 name: hcfc1-zbtb17-8 physical interaction comment: GST pull-down to identify which region(s) of zbtb17 (Miz1) are required for interaction with hcfc1. xref: IntAct:EBI-624075 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0007120 name: uhrf2-cdk2-4 direct interaction comment: Phosphorylation of UHRF2 (NIRF) by CDK2 xref: IntAct:EBI-625393 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0002054 ! UHRF2_HUMAN [Term] id: CCO:I0007121 name: hcfc1-many-1 physical interaction comment: mass spectrometric analaysis of interaction between hcfc1 and many other proteins xref: IntAct:EBI-629953 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001727 ! RBBP4_HUMAN relationship: has_participant CCO:B0005343 ! HDAC2_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN relationship: has_participant CCO:B0005485 ! SP1_HUMAN relationship: has_participant CCO:B0005613 ! SET1A_HUMAN relationship: has_participant CCO:B0005614 ! ASH2L_HUMAN relationship: has_participant CCO:B0005615 ! WDR5_HUMAN relationship: has_participant CCO:B0005694 ! SDS3_HUMAN relationship: has_participant CCO:B0005806 ! OGT1_HUMAN relationship: has_participant CCO:B0005809 ! RBBP7_HUMAN [Term] id: CCO:I0007122 name: egfr-cbl1-1 direct interaction comment: Interaction between human EGFR and c-Cbl xref: IntAct:EBI-641001 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:I0007123 name: egfr-cbl1-4 direct interaction comment: Interaction between human EGFR and c-Cbl xref: IntAct:EBI-678899 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005611 ! CBL_HUMAN [Term] id: CCO:I0007124 name: actn2-ttn-3 physical interaction comment: Interaction of alpha Actinin-2 and Titin, as detected by affinity techs using Biosensor assay. xref: IntAct:EBI-698598 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005642 ! ACTN2_HUMAN [Term] id: CCO:I0007125 name: actn2-ttn-6 physical interaction comment: Titin, alpha-actinin and F-actin form ternary complexes in vitro. xref: IntAct:EBI-698824 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005642 ! ACTN2_HUMAN relationship: has_participant CCO:B0005810 ! ACTA_HUMAN [Term] id: CCO:I0007126 name: egfr-yes-1 physical interaction comment: Proteomics studies using anti-EGFR affinity chromatography xref: IntAct:EBI-702075 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001418 ! DNJA2_HUMAN relationship: has_participant CCO:B0001437 ! BCAR3_HUMAN relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001559 ! 1433T_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0001584 ! 1433S_HUMAN relationship: has_participant CCO:B0001695 ! UBIQ_HUMAN relationship: has_participant CCO:B0005204 ! TRI29_HUMAN relationship: has_participant CCO:B0005235 ! HNRPK_HUMAN relationship: has_participant CCO:B0005379 ! STAT3_HUMAN relationship: has_participant CCO:B0005409 ! IMB1_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN relationship: has_participant CCO:B0005456 ! CAV1_HUMAN relationship: has_participant CCO:B0005463 ! 4F2_HUMAN relationship: has_participant CCO:B0005465 ! YES_HUMAN relationship: has_participant CCO:B0005488 ! 1433E_HUMAN relationship: has_participant CCO:B0005540 ! ERBB2_HUMAN relationship: has_participant CCO:B0005580 ! HS90B_HUMAN relationship: has_participant CCO:B0005611 ! CBL_HUMAN relationship: has_participant CCO:B0005662 ! XPO2_HUMAN relationship: has_participant CCO:B0005664 ! XPOT_HUMAN relationship: has_participant CCO:B0005699 ! HSP7C_HUMAN relationship: has_participant CCO:B0005727 ! TBB5_HUMAN relationship: has_participant CCO:B0005730 ! CH60_HUMAN relationship: has_participant CCO:B0005732 ! HNRH1_HUMAN relationship: has_participant CCO:B0005771 ! H2B1C_HUMAN relationship: has_participant CCO:B0005772 ! TBA1A_HUMAN relationship: has_participant CCO:B0005808 ! THIO_HUMAN relationship: has_participant CCO:B0005811 ! K2C5_HUMAN relationship: has_participant CCO:B0005812 ! FAK1_HUMAN relationship: has_participant CCO:B0005813 ! ADT2_HUMAN relationship: has_participant CCO:B0005814 ! HNRPF_HUMAN relationship: has_participant CCO:B0005815 ! EFNB1_HUMAN relationship: has_participant CCO:B0005816 ! ATX10_HUMAN relationship: has_participant CCO:B0005817 ! K1C14_HUMAN relationship: has_participant CCO:B0005818 ! DNJA3_HUMAN relationship: has_participant CCO:B0005819 ! CBLB_HUMAN relationship: has_participant CCO:B0005820 ! PEX19_HUMAN relationship: has_participant CCO:B0005821 ! K2C6A_HUMAN relationship: has_participant CCO:B0005822 ! HSP71_HUMAN relationship: has_participant CCO:B0005823 ! K2C1_HUMAN relationship: has_participant CCO:B0005824 ! CTNA1_HUMAN relationship: has_participant CCO:B0005825 ! S10AB_HUMAN relationship: has_participant CCO:B0005826 ! PKP2_HUMAN relationship: has_participant CCO:B0005827 ! ATPB_HUMAN relationship: has_participant CCO:B0005828 ! GRP75_HUMAN relationship: has_participant CCO:B0005829 ! CKAP4_HUMAN relationship: has_participant CCO:B0005830 ! FHL2_HUMAN relationship: has_participant CCO:B0005831 ! EF1A1_HUMAN relationship: has_participant CCO:B0005832 ! EPHA2_HUMAN relationship: has_participant CCO:B0005833 ! EPHB4_HUMAN relationship: has_participant CCO:B0005834 ! EI2BG_HUMAN relationship: has_participant CCO:B0005835 ! DNJA1_HUMAN relationship: has_participant CCO:B0005836 ! ACK1_HUMAN relationship: has_participant CCO:B0005837 ! PAXI_HUMAN relationship: has_participant CCO:B0005838 ! H14_HUMAN relationship: has_participant CCO:B0005839 ! CTND1_HUMAN relationship: has_participant CCO:B0005840 ! AT2A2_HUMAN relationship: has_participant CCO:B0005841 ! BCAR1_HUMAN relationship: has_participant CCO:B0005842 ! HSPB1_HUMAN relationship: has_participant CCO:B0005843 ! GRP78_HUMAN relationship: has_participant CCO:B0005844 ! K1C17_HUMAN relationship: has_participant CCO:B0005845 ! LRC59_HUMAN relationship: has_participant CCO:B0005846 ! FAK2_HUMAN relationship: has_participant CCO:B0005847 ! MPCP_HUMAN [Term] id: CCO:I0007127 name: wrn-rad52-6 physical interaction comment: In vivo Co-IP: bait= WRN, prey= RAD52 xref: IntAct:EBI-706526 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007128 name: wrn-rad52-7 physical interaction comment: In vivo Co-IP: bait= RAD52, prey= WRN xref: IntAct:EBI-706533 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007131 name: terf2ip-rad50 physical interaction comment: Coimmunoprecipitaion reveals interaction between RAP1, RAD50, Mre11, Ku86, TRF2, HSP70 and TINF2 proteins xref: IntAct:EBI-764884 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001788 ! MDC1_HUMAN relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005505 ! TE2IP_HUMAN [Term] id: CCO:I0007133 name: brca2-shfdg1-1 physical interaction comment: Interaction detected by Y2H. xref: IntAct:EBI-79835 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0005586 ! DSS1_HUMAN [Term] id: CCO:I0007135 name: dlg1-kif13b-3 physical interaction comment: Co-IP: bait= GAKIN,prey = hDlg (SAP97) xref: IntAct:EBI-874729 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001736 ! DLG1_HUMAN relationship: has_participant CCO:B0005849 ! KI13B_HUMAN [Term] id: CCO:I0007136 name: gli3-sufu-1 direct interaction comment: Interaction between GLI3 and SUFU demonstrated by GST pulldown xref: IntAct:EBI-875115 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005850 ! GLI3_HUMAN [Term] id: CCO:I0007137 name: sufu-sufu-1 direct interaction comment: Homodimerisation of SUFU demonstrated by GST pulldown xref: IntAct:EBI-875131 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002232 ! SUFU_HUMAN [Term] id: CCO:I0007143 name: erbb3-pa2g4-1 physical interaction xref: IntAct:EBI-931862 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN relationship: has_participant CCO:B0005852 ! ERBB3_HUMAN [Term] id: CCO:I0007144 name: pa2g4-ar-1 physical interaction xref: IntAct:EBI-931867 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN relationship: has_participant CCO:B0005356 ! ANDR_HUMAN [Term] id: CCO:I0007145 name: pa2g4-ncl-top1-1 physical interaction xref: IntAct:EBI-932569 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN relationship: has_participant CCO:B0005587 ! TOP1_HUMAN relationship: has_participant CCO:B0005733 ! NUCL_HUMAN relationship: has_participant CCO:B0005741 ! RL18_HUMAN relationship: has_participant CCO:B0005762 ! RLA0_HUMAN relationship: has_participant CCO:B0005853 ! RL28_HUMAN relationship: has_participant CCO:B0005854 ! PABP1_HUMAN relationship: has_participant CCO:B0005855 ! RL12_HUMAN relationship: has_participant CCO:B0005856 ! RL24_HUMAN relationship: has_participant CCO:B0005857 ! RL15_HUMAN relationship: has_participant CCO:B0005858 ! RL11_HUMAN relationship: has_participant CCO:B0005859 ! RL27_HUMAN relationship: has_participant CCO:B0005860 ! RL8_HUMAN relationship: has_participant CCO:B0005861 ! RL4_HUMAN relationship: has_participant CCO:B0005862 ! RL21_HUMAN relationship: has_participant CCO:B0005863 ! H11_HUMAN relationship: has_participant CCO:B0005864 ! RLA2_HUMAN [Term] id: CCO:I0007146 name: p300-tfap2a-1 physical interaction comment: Interaction between human p300 and TFAP2A detected by coIP xref: IntAct:EBI-937720 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0007147 name: p300-cited2-1 physical interaction comment: Interaction between human p300 and CITED2 detected by coIP xref: IntAct:EBI-937728 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0002091 ! CITE2_HUMAN [Term] id: CCO:I0007148 name: s100b-s100a11-s100a6 colocalization comment: Colocalisation of human S100B, S100A11 and S100A6 detected by confocal microscopy xref: IntAct:EBI-959993 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001494 ! S10A6_HUMAN relationship: has_participant CCO:B0005378 ! S100B_HUMAN relationship: has_participant CCO:B0005825 ! S10AB_HUMAN [Term] id: CCO:I0007149 name: dusp1-skp2-3 physical interaction comment: Interaction between DUSP1 and SKP2 demonstrated by coimmunoprecipitation xref: IntAct:EBI-975649 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001566 ! DUS1_HUMAN relationship: has_participant CCO:B0001628 ! UB2R1_HUMAN relationship: has_participant CCO:B0001695 ! UBIQ_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN [Term] id: CCO:I0007150 name: cbp-atf3 physical interaction xref: IntAct:EBI-981234 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005865 ! TF65_HUMAN [Term] id: CCO:I0007151 name: brca2-rad51-8 physical interaction comment: Interaction between BRCA2 and RAD51 determined by GST-pulldown xref: IntAct:EBI-987332 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007153 name: ranbp3-ran-1 physical interaction xref: IntAct:EBI-992712 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:I0007154 name: ranbp3-rcc1-1 physical interaction xref: IntAct:EBI-992738 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:I0007155 name: rcc1-xpo1-1 physical interaction xref: IntAct:EBI-992749 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0005867 ! XPO1_HUMAN [Term] id: CCO:I0007156 name: kntc2-cdca1-4 physical interaction xref: IntAct:EBI-1000008 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN [Term] id: CCO:I0007157 name: kntc2_zwint_2 physical interaction comment: pull down: bait=kntc2, prey=zwint xref: IntAct:EBI-1001499 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0007158 name: zwint_kntc2_2 physical interaction comment: pull down: bait=zwint, preys=kntc2, zw10 xref: IntAct:EBI-1001508 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0007159 name: kntc2_zwint_3 physical interaction comment: pull down: bait=kntc2, preys=zwint, zw10 xref: IntAct:EBI-1001525 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0007160 name: zw10_kntc2_1 physical interaction comment: pull down: bait=zw10, preys=kntc2, zwint xref: IntAct:EBI-1001549 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0007161 name: zwint_kntc2_3 physical interaction comment: coIP: bait=zwint, prey=kntc2 xref: IntAct:EBI-1001631 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0007162 name: zw10_kntc2_2 physical interaction comment: coIP: bait=zw10, prey=kntc2 xref: IntAct:EBI-1001639 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0007163 name: raf1-rap1a-2 direct interaction comment: Human rap1a, residues 1-167, double mutant (e30d,k31e) complexed with gppnhp and the ras-binding-domain of human c-raf1, residues 51-131 xref: IntAct:EBI-1026154 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001694 ! RAP1A_HUMAN relationship: has_participant CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:I0007166 name: tp53-tp53bp1-1 direct interaction comment: Crystal structure of the 53bp1 brct region complexed to tumor suppressor p53 xref: IntAct:EBI-1033085 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:I0007167 name: egfr-tgfa-1 direct interaction comment: Crystal structure of human epidermal growth factor receptor (residues 1-501) in complex with tgf-alpha xref: IntAct:EBI-1034394 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005870 ! TGFA_HUMAN [Term] id: CCO:I0007169 name: kntc2-spbc24-4 physical interaction xref: IntAct:EBI-1101410 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0007171 name: abl1-rin1-4 phosphorylation comment: Phosphorylation of Rin1 by Abl1 xref: IntAct:EBI-1103017 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005385 ! RIN1_HUMAN [Term] id: CCO:I0007172 name: tacc1-yeats4-4 colocalization xref: IntAct:EBI-1151873 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001451 ! YETS4_HUMAN [Term] id: CCO:I0007173 name: dj_1-ubc9 physical interaction xref: IntAct:EBI-1164415 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005443 ! PARK7_HUMAN [Term] id: CCO:I0007175 name: hif1a-os9-4 direct interaction comment: GST-HIF-1-alpha pulls down OS-9 and VHL xref: IntAct:EBI-1175463 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001600 ! VHL_HUMAN relationship: has_participant CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:I0007176 name: hif1a-vhl physical interaction comment: GST-HIF-1 alpha pulls down VHL xref: IntAct:EBI-1175529 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001600 ! VHL_HUMAN relationship: has_participant CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:I0007177 name: cspg6-rad21 physical interaction xref: IntAct:EBI-1175616 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN [Term] id: CCO:I0007178 name: chek2-aatf-1 physical interaction comment: Che-1 coimmunoprecipitates with Chk2 xref: IntAct:EBI-1180890 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001459 ! CHK2_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0007179 name: prkaa1-aakg1-1 physical interaction comment: Binding partners of PRKAA1 identified by mass spectrometry xref: IntAct:EBI-1181432 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005872 ! AAPK1_HUMAN [Term] id: CCO:I0007180 name: snf1lk-ywhaz-1 physical interaction comment: Binding partners of SNF1LK (SIK) identified by mass spectrometry xref: IntAct:EBI-1181636 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001680 ! SN1L1_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN relationship: has_participant CCO:B0005488 ! 1433E_HUMAN [Term] id: CCO:I0007182 name: nuak2-cdc37-1 physical interaction comment: Binding partners of NUAK2 identified by mass spectrometry xref: IntAct:EBI-1181741 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005874 ! NUAK2_HUMAN [Term] id: CCO:I0007183 name: snf1lk-ywhaz-2 direct interaction comment: Interaction between 14-3-3Z and SNF1LK (SIK)identified by pulldown xref: IntAct:EBI-1181931 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001680 ! SN1L1_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0007187 name: myc-snip1-3 physical interaction comment: Endogenous SNIP1 complex formation with endogenous c-Myc varies with cell cycle progression xref: IntAct:EBI-1190137 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005335 ! SNIP1_HUMAN [Term] id: CCO:I0007188 name: myc-skp2-1 physical interaction comment: Endogenous Skp2 complex formation with endogenous c-Myc varies with cell cycle progression xref: IntAct:EBI-1190143 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN [Term] id: CCO:I0007189 name: hdac1-brms1 physical interaction comment: HDAC1 coimmunoprecipitates BRMS1 xref: IntAct:EBI-1200310 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0007190 name: hdac2-brms1 physical interaction comment: HDAC2 coimmunoprecipitates BRMS1 xref: IntAct:EBI-1200318 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:I0007191 name: hdac3-brms1 physical interaction comment: HDAC3 coimmunoprecipitates BRMS1 xref: IntAct:EBI-1200326 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001376 ! HDAC3_HUMAN relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN [Term] id: CCO:I0007192 name: hdac4-brms1 physical interaction comment: HDAC4 coimmunoprecipitates BRMS1 xref: IntAct:EBI-1200336 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001679 ! HDAC4_HUMAN relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN [Term] id: CCO:I0007193 name: hdac5-brms1 physical interaction comment: HDAC5 coimmunoprecipitates BRMS1 xref: IntAct:EBI-1200344 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0002244 ! HDAC5_HUMAN [Term] id: CCO:I0007194 name: hdac6-brms1 physical interaction comment: HDAC6 coimmunoprecipitates BRMS1 xref: IntAct:EBI-1200352 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0002192 ! HDAC6_HUMAN [Term] id: CCO:I0007195 name: lck-ptprc physical interaction comment: Lck-CD45 demonstrated in vitro xref: IntAct:EBI-1356 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001490 ! LCK_HUMAN relationship: has_participant CCO:B0001499 ! CD45_HUMAN [Term] id: CCO:I0007196 name: krt18-shc1-1 colocalization comment: Colocalization by confocal microscopy of fluroscence labeled proteins. xref: IntAct:EBI-298042 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN [Term] id: CCO:I0007197 name: egfr-h3fa-1 colocalization comment: Colocalization indicated by confocal microscopy of fluroscently tagged proteins. xref: IntAct:EBI-298046 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005221 ! H31_HUMAN [Term] id: CCO:I0007198 name: egfr-cd59-1 direct interaction comment: Interaction detected by FRET. xref: IntAct:EBI-298103 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005875 ! CD59_HUMAN [Term] id: CCO:I0007199 name: pard3-pard6b-2 physical interaction comment: Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network xref: IntAct:EBI-306756 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN [Term] id: CCO:I0007200 name: pard3-pard6a-3 physical interaction comment: Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network xref: IntAct:EBI-306767 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN [Term] id: CCO:I0007201 name: stk11-mo25-1 physical interaction comment: Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network xref: IntAct:EBI-306911 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0005876 ! CAB39_HUMAN [Term] id: CCO:I0007202 name: pard3-pard6a-2 physical interaction comment: Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network xref: IntAct:EBI-306996 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN [Term] id: CCO:I0007203 name: pard6a-prkci-2 physical interaction comment: Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network xref: IntAct:EBI-306999 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0007204 name: pard6a-par6b-1 physical interaction comment: Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network xref: IntAct:EBI-307005 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN [Term] id: CCO:I0007205 name: pard6a-cdc42-5 physical interaction comment: CoIP: bait = pard6a, prey = cdc42 xref: IntAct:EBI-307047 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0007206 name: prkci-pard6a-1 physical interaction comment: Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network xref: IntAct:EBI-307119 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0007207 name: prkci-pard6b-2 physical interaction comment: Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network xref: IntAct:EBI-307122 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0007208 name: als2cr2-stk11-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-307241 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0002119 ! AL2S2_HUMAN [Term] id: CCO:I0007209 name: mo25-als2cr2-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-307245 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002119 ! AL2S2_HUMAN relationship: has_participant CCO:B0005876 ! CAB39_HUMAN [Term] id: CCO:I0007210 name: pard6a-mark4-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-307250 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005344 ! MARK4_HUMAN [Term] id: CCO:I0007211 name: prkci-pard3-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-307257 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0007212 name: ywhaz-pard3-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-347038 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0007213 name: pard6a-ywhah-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-349731 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005490 ! 1433F_HUMAN [Term] id: CCO:I0007214 name: pard6a-ywhaz-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-349738 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0007215 name: pard6b-ywhah-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-349750 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005490 ! 1433F_HUMAN [Term] id: CCO:I0007216 name: pard6b-ywhaz-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-349754 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0007217 name: stk11-mark4-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-354792 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0005344 ! MARK4_HUMAN [Term] id: CCO:I0007218 name: pard3-ywhaz-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-354812 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0007219 name: ywhah-pard3-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-354820 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0005490 ! 1433F_HUMAN [Term] id: CCO:I0007220 name: pard3-ywhah-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-354826 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0005490 ! 1433F_HUMAN [Term] id: CCO:I0007221 name: pard3-prkci-2 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-354833 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0007222 name: mo25-stk11-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-354838 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0005876 ! CAB39_HUMAN [Term] id: CCO:I0007223 name: stk11-als2cr2-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-354843 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0002119 ! AL2S2_HUMAN [Term] id: CCO:I0007224 name: cdc42-pard6a-2 physical interaction comment: CoIP: bait = human cdc42, prey = human pard6a xref: IntAct:EBI-360124 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0007225 name: pard6b-cdc42-6 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-360129 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0007226 name: cdc42-pard6b-3 physical interaction comment: CoIP: bait = human cdc42, prey = par6B xref: IntAct:EBI-360134 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0007227 name: pard6b-pnma1-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-360139 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005877 ! PNMA1_HUMAN [Term] id: CCO:I0007228 name: pnma1-pard6b-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-360144 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005877 ! PNMA1_HUMAN [Term] id: CCO:I0007229 name: pard6b-prkci-3 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-360149 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0007230 name: pard6b-pard3-2 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-360154 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0005877 ! PNMA1_HUMAN [Term] id: CCO:I0007231 name: pard3-pnma1-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-360166 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0005877 ! PNMA1_HUMAN [Term] id: CCO:I0007232 name: pnma1-pard3-1 physical interaction comment: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network xref: IntAct:EBI-360171 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0005877 ! PNMA1_HUMAN [Term] id: CCO:I0007233 name: rad51-tp53-1 physical interaction comment: Interaction of p53 and the human Rad51 protein detected by Co-IP. xref: IntAct:EBI-367003 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007234 name: rad51-tp53-2 physical interaction comment: Interaction of p53 with the human Rad51 protein detected by CO-IP xref: IntAct:EBI-367053 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007235 name: nek1-fez2-2 physical interaction comment: Interaction between NEK1 requlatory domain and ZBRK1 identified by Y2H xref: IntAct:EBI-396634 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005394 ! FEZ2_HUMAN [Term] id: CCO:I0007236 name: lats1-zyx-6 colocalization comment: Interaction betwen human LATS1 and ZYX demonstrate by colocalization studies xref: IntAct:EBI-444294 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0007237 name: lats1-limk1-5 colocalization comment: Colocalization of human LATS1 and LIMK1 xref: IntAct:EBI-444493 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005606 ! LIMK1_HUMAN [Term] id: CCO:I0007239 name: cdt1-cdc6-1 physical interaction comment: Interaction of CDT1 and CDC6 identified by GST pull-down xref: IntAct:EBI-457031 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0002126 ! CDT1_HUMAN [Term] id: CCO:I0007240 name: cdt1-cdc6-2 physical interaction comment: Interaction of CDT1 and CDC6 identified by GST pull-down xref: IntAct:EBI-457078 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0002126 ! CDT1_HUMAN [Term] id: CCO:I0007241 name: hd-p53-2 physical interaction comment: GST-pull down : bait = huntingtin poly(Q) region ; prey = P53 xref: IntAct:EBI-492998 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005407 ! HD_HUMAN [Term] id: CCO:I0007242 name: p53-crebbp-1 physical interaction comment: GST-pull down : bait = P53 ; prey = CBP (CREB binding protein) xref: IntAct:EBI-493156 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005339 ! CBP_HUMAN [Term] id: CCO:I0007243 name: p53-sin3a-1 physical interaction comment: GST-pull down : bait = P53 ; prey = Sin3a xref: IntAct:EBI-493181 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:I0007244 name: pkmyt1-ccnb1-1 physical interaction xref: IntAct:EBI-495328 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001519 ! CCNB1_HUMAN relationship: has_participant CCO:B0002078 ! PMYT1_HUMAN [Term] id: CCO:I0007245 name: ccnb1-pkmyt1-1 physical interaction xref: IntAct:EBI-495391 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001519 ! CCNB1_HUMAN relationship: has_participant CCO:B0002078 ! PMYT1_HUMAN [Term] id: CCO:I0007247 name: cdk2-ccne1-2 physical interaction comment: Co-IP : bait=cdk2, prey = cyclin E1 xref: IntAct:EBI-519746 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007248 name: cdk4-ccnd1-6 physical interaction comment: Co-IP : bait=cdk4, prey = cyclin D1 xref: IntAct:EBI-519761 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN [Term] id: CCO:I0007249 name: rent1-stau-6 physical interaction xref: IntAct:EBI-536644 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005434 ! REN3B_HUMAN relationship: has_participant CCO:B0005435 ! RENT2_HUMAN [Term] id: CCO:I0007251 name: hcfc1-sin3a-2 physical interaction comment: Y2H of interaction between specific regions of hcfc1 and sin3a xref: IntAct:EBI-540758 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:I0007253 name: trx-jab1-cdn1b physical interaction comment: Pulldown analysis reveals interaction between the cyclin-dependent kinase inhibitor 1B , thioredoxin and the COP9 signalosome complex subunit 5 protein xref: IntAct:EBI-594810 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0002025 ! CSN5_HUMAN [Term] id: CCO:I0007254 name: cand1-cul1-2 physical interaction comment: GST pulldown reveals interaction between the TIP120A (CAND1) protein and cullin1 protein xref: IntAct:EBI-597737 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN [Term] id: CCO:I0007255 name: gpsm2-numa1-3 physical interaction xref: IntAct:EBI-618880 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:I0007256 name: huew1-cdkn2a-1 physical interaction comment: coIP: bait = arf-bp1/mule, prey = p14arf xref: IntAct:EBI-626122 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001966 ! CD2A2_HUMAN relationship: has_participant CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:I0007257 name: cdkn2a-huew1-3 physical interaction comment: coIP: bait = p14arf, prey = arf-bp1/mule xref: IntAct:EBI-626129 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001966 ! CD2A2_HUMAN relationship: has_participant CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:I0007258 name: smarcb1-arid2-1 physical interaction comment: coIP: bait = flag-hsnf5; prey = baf200 xref: IntAct:EBI-637847 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0005497 ! ARID2_HUMAN [Term] id: CCO:I0007259 name: arid2-pb1-1 physical interaction comment: coIP: bait = flag-baf200, preys = baf180, brg1, baf170, baf155, baf57, hsnf5 xref: IntAct:EBI-637916 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0001938 ! PB1_HUMAN relationship: has_participant CCO:B0005497 ! ARID2_HUMAN [Term] id: CCO:I0007260 name: brg1-baf250a-1 physical interaction comment: coIP: bait = brg1, preys = baf250a, baf170, baf155, baf60a, baf53, snf5, actin xref: IntAct:EBI-637974 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:I0007261 name: hcfc1-gabp2-3 physical interaction comment: GST pull-down of interaction between hcfc1 and gabp2. xref: IntAct:EBI-638915 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0040683 ! GABP1_HUMAN [Term] id: CCO:I0007262 name: hcfc1-gabpa-1 physical interaction comment: GST pull-down of interaction between hcfc1 and gabpa. xref: IntAct:EBI-638943 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005878 ! GABPA_HUMAN [Term] id: CCO:I0007263 name: hcfc1-gabp2-4 direct interaction comment: GST pull-down of interaction between hcfc1 and gabp2. xref: IntAct:EBI-638955 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005878 ! GABPA_HUMAN relationship: has_participant CCO:B0040683 ! GABP1_HUMAN [Term] id: CCO:I0007264 name: hcfc1-creb3-3 direct interaction comment: Immunoblot (Co-ip) showing interaction between hcfc1 and creb3 and between hcfc1 and zf xref: IntAct:EBI-640523 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005498 ! CREB3_HUMAN [Term] id: CCO:I0007265 name: hcfc1-zf-6 direct interaction comment: Immunoblot (Co-ip) showing interaction between hcfc1 and creb3 and between hcfc1 and zf xref: IntAct:EBI-641398 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005710 ! ZHANG_HUMAN [Term] id: CCO:I0007266 name: hcfc1-creb3-4 direct interaction comment: Immunoblot (Co-ip) showing interaction between hcfc1 and creb3 xref: IntAct:EBI-641418 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005498 ! CREB3_HUMAN [Term] id: CCO:I0007267 name: hcfc1-zf-7 direct interaction comment: Immunoblot (Co-ip) showing interaction between hcfc1 and zf xref: IntAct:EBI-641438 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005710 ! ZHANG_HUMAN [Term] id: CCO:I0007268 name: nek1-fez1-3 physical interaction comment: Interaction between NEK1 requlatory domain and ZBRK1 identified by Y2H xref: IntAct:EBI-695904 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005393 ! FEZ1_HUMAN [Term] id: CCO:I0007269 name: nek1-ywhah-1 physical interaction comment: Interaction between NEK1 requlatory domain and YWHAHidentified by Y2H xref: IntAct:EBI-695925 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005490 ! 1433F_HUMAN [Term] id: CCO:I0007270 name: nek1-xh2-1 physical interaction comment: Interaction between NEK1 requlatory domain and XH2 identified by Y2H xref: IntAct:EBI-695931 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005879 ! ATRX_HUMAN [Term] id: CCO:I0007271 name: nek1-mre11-1 physical interaction comment: Interaction between NEK1 requlatory domain and MRE11 identified by Y2H xref: IntAct:EBI-695941 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001641 ! MRE11_HUMAN relationship: has_participant CCO:B0002055 ! NEK1_HUMAN [Term] id: CCO:I0007272 name: nek1-tp53bp1-1 physical interaction comment: Interaction between NEK1 requlatory domain and TP53BP1 identified by Y2H xref: IntAct:EBI-695947 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005412 ! TP53B_HUMAN [Term] id: CCO:I0007273 name: nek1-kif3a physical interaction comment: Interaction between NEK1 requlatory domain and KIF3A identified by Y2H xref: IntAct:EBI-695956 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005880 ! KIF3A_HUMAN [Term] id: CCO:I0007274 name: nek1-ppp2r5d-1 physical interaction comment: Interaction between NEK1 requlatory domain and PPP2R5D identified by Y2H xref: IntAct:EBI-695966 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005515 ! 2A5D_HUMAN [Term] id: CCO:I0007275 name: nek1-tsc2-1 physical interaction comment: Interaction between NEK1 requlatory domain and TSC2 identified by Y2H xref: IntAct:EBI-695974 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001637 ! TSC2_HUMAN relationship: has_participant CCO:B0002055 ! NEK1_HUMAN [Term] id: CCO:I0007276 name: nek1-ctnnal1-1 physical interaction comment: Interaction between NEK1 requlatory domain and CTNNAL1 identified by Y2H xref: IntAct:EBI-695982 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005881 ! CTNL1_HUMAN [Term] id: CCO:I0007277 name: nek1-tsc2-2 physical interaction comment: Interaction between NEK1 kinase domain and TSC2 identified by Y2H xref: IntAct:EBI-696008 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001637 ! TSC2_HUMAN relationship: has_participant CCO:B0002055 ! NEK1_HUMAN [Term] id: CCO:I0007278 name: nek1-tsc2-3 physical interaction comment: Interaction between NEK1 kinase domain and TSC2 identified by Y2H xref: IntAct:EBI-696015 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0005515 ! 2A5D_HUMAN [Term] id: CCO:I0007279 name: nek1-nek1-1 physical interaction comment: Homodimerization of NEK1 identified by Y2H xref: IntAct:EBI-696022 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002055 ! NEK1_HUMAN [Term] id: CCO:I0007283 name: blm-terf2-1 physical interaction comment: In vivo Co-IP: bait= BLM, prey =TRF2 xref: IntAct:EBI-710854 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0007284 name: app-tp53bp2-1 physical interaction comment: APP- TP53BP2 xref: IntAct:EBI-77660 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007285 name: app-tp53bp2-3 physical interaction comment: APP-TP53BP2 pulldown xref: IntAct:EBI-77665 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007286 name: adam9-mad2l2-1 physical interaction xref: IntAct:EBI-77923 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002204 ! MD2L2_HUMAN relationship: has_participant CCO:B0005372 ! ADAM9_HUMAN [Term] id: CCO:I0007287 name: dnmt3b-ube2i-1 physical interaction xref: IntAct:EBI-80228 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005423 ! DNM3B_HUMAN [Term] id: CCO:I0007289 name: pold1-pold2-4 physical interaction comment: Assembly of DNA polymerase delta identifed by column chromotography xref: IntAct:EBI-865032 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005882 ! DPOD4_HUMAN relationship: has_participant CCO:B0005883 ! DPOD2_HUMAN relationship: has_participant CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:I0007290 name: pold1-pold2-5 physical interaction comment: Assembly of DNA polymerase delta subunits 1 and 2 identifed by column chromotography xref: IntAct:EBI-865046 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005883 ! DPOD2_HUMAN [Term] id: CCO:I0007291 name: pole3-pole4-6 physical interaction comment: Interaction between POLE3 and POLE4 identified by coimmunoprecipitation xref: IntAct:EBI-867144 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001724 ! DPOE1_HUMAN relationship: has_participant CCO:B0005885 ! DPOE3_HUMAN [Term] id: CCO:I0007292 name: tle1-aml2-1 physical interaction comment: Interaction between human TLE1 and AML2 detected by beta galactosidase xref: IntAct:EBI-926094 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001766 ! RUNX3_HUMAN relationship: has_participant CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:I0007294 name: pa2g4-ncl-1 physical interaction xref: IntAct:EBI-932860 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN relationship: has_participant CCO:B0005733 ! NUCL_HUMAN [Term] id: CCO:I0007297 name: sgol1-ppp2r5a-2 colocalization xref: IntAct:EBI-989200 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001847 ! SGOL1_HUMAN relationship: has_participant CCO:B0005516 ! 2A5A_HUMAN [Term] id: CCO:I0007298 name: rcc1-ranbp3-1 physical interaction xref: IntAct:EBI-992766 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0005866 ! RANB3_HUMAN [Term] id: CCO:I0007300 name: daz1-boll-1 physical interaction xref: IntAct:EBI-998221 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001972 ! BOLL_HUMAN relationship: has_participant CCO:B0005886 ! DAZ1_HUMAN [Term] id: CCO:I0007301 name: kntc2-spbc24-1 physical interaction xref: IntAct:EBI-999950 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0007302 name: spbc24-spbc25-3 physical interaction xref: IntAct:EBI-999976 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0007303 name: kntc2-cdca1-3 physical interaction xref: IntAct:EBI-999994 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN [Term] id: CCO:I0007304 name: erbb2-egfr-2 physical interaction xref: IntAct:EBI-1000739 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005540 ! ERBB2_HUMAN [Term] id: CCO:I0007305 name: erbb2-egfr-3 physical interaction xref: IntAct:EBI-1000759 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005540 ! ERBB2_HUMAN [Term] id: CCO:I0007306 name: smc1-mcm7-6 physical interaction comment: Interaction between human Smc1 and MCM7 detected by coIP xref: IntAct:EBI-1004776 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0007307 name: smc1-rfc1-1 physical interaction comment: Interaction between human Smc1 and RFC1 detected by coIP xref: IntAct:EBI-1004786 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0005887 ! RFC1_HUMAN [Term] id: CCO:I0007308 name: smc1-dpola-1 physical interaction comment: Interaction between human Smc1 and DNA polymerase alpha detected by coIP xref: IntAct:EBI-1004802 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001503 ! DPOLA_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0007309 name: rb1-hdac1 physical interaction xref: IntAct:EBI-1025609 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0007310 name: ran-tnpo1-1 direct interaction comment: Structure of the karyopherin beta2-ran gppnhp nuclear transport complex xref: IntAct:EBI-1027757 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0005663 ! TNPO1_HUMAN [Term] id: CCO:I0007314 name: tacc1-ckap5 physical interaction xref: IntAct:EBI-1151162 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001772 ! CKAP5_HUMAN [Term] id: CCO:I0007315 name: tacc1-yeats4 physical interaction xref: IntAct:EBI-1151252 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001451 ! YETS4_HUMAN [Term] id: CCO:I0007316 name: bhlbh2-ube2i physical interaction xref: IntAct:EBI-1164831 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005888 ! BHLH2_HUMAN [Term] id: CCO:I0007318 name: cdca1-kntc2 physical interaction comment: Copurification of the two subunits of the human Ndc80 complex: Hec1/hNdc80 and hNuf2 xref: IntAct:EBI-1176296 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN [Term] id: CCO:I0007322 name: mapkapk5-tp53 phosphorylation comment: Human HA-PRAK phosphorylates human p53 in vitro xref: IntAct:EBI-1201485 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005891 ! MAPK5_HUMAN [Term] id: CCO:I0007323 name: cdkn1b-cdk2-4 physical interaction comment: interaction between CDKN1B, CDK2 and CCNA2 demonstrated by NMR xref: IntAct:EBI-1201881 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007324 name: mapkapk5-tp53-1 phosphorylation comment: Human His-PRAK phosphorylates human p53 in vitro xref: IntAct:EBI-1202077 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005891 ! MAPK5_HUMAN [Term] id: CCO:I0007325 name: mapk11-tp53-1 phosphorylation comment: Human p38 isolated from BJ cells phosphorylates p53 in vitro xref: IntAct:EBI-1206378 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005892 ! MK11_HUMAN [Term] id: CCO:I0007326 name: ncoa6-rara-1 physical interaction comment: Interaction detected by Y2H. xref: IntAct:EBI-286342 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0005893 ! NCOA6_HUMAN [Term] id: CCO:I0007327 name: ncoa6-rara-2 physical interaction comment: Regions of hNCOA6 important for interactions determined by Y2H. xref: IntAct:EBI-286389 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0005893 ! NCOA6_HUMAN [Term] id: CCO:I0007328 name: eif4gii-eif4aii physical interaction comment: A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery xref: IntAct:EBI-296538 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001699 ! IF4G2_HUMAN relationship: has_participant CCO:B0005728 ! IF4A2_HUMAN [Term] id: CCO:I0007329 name: hck-dnm2-1 physical interaction comment: Interaction between HCK and DNM2 detected by GST pull down xref: IntAct:EBI-346570 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0005894 ! HCK_HUMAN [Term] id: CCO:I0007330 name: hck-p62-1 physical interaction comment: Interaction between HCK and P62 detected by GST pull down xref: IntAct:EBI-346693 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005894 ! HCK_HUMAN [Term] id: CCO:I0007331 name: hck-cd2ap-1 physical interaction comment: Interaction between HCK and CD2AP detected by GST pull down xref: IntAct:EBI-346699 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002257 ! CD2AP_HUMAN relationship: has_participant CCO:B0005894 ! HCK_HUMAN [Term] id: CCO:I0007333 name: pbx2-p22 physical interaction xref: IntAct:EBI-348688 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001440 ! DCTN3_HUMAN relationship: has_participant CCO:B0005895 ! PBX2_HUMAN [Term] id: CCO:I0007334 name: stk19-pole physical interaction xref: IntAct:EBI-348706 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001724 ! DPOE1_HUMAN relationship: has_participant CCO:B0005896 ! STK19_HUMAN [Term] id: CCO:I0007337 name: bat2-mad2l2 physical interaction xref: IntAct:EBI-348871 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002204 ! MD2L2_HUMAN relationship: has_participant CCO:B0005898 ! BAT2_HUMAN [Term] id: CCO:I0007339 name: mdm2-mdm4-2 physical interaction comment: MDMX and MDM2 associate in vitro. xref: IntAct:EBI-399552 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001366 ! MDM4_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0007340 name: mdm2-mdm4-3 physical interaction comment: MDMX and MDM2 associate in vitro. xref: IntAct:EBI-399556 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001366 ! MDM4_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0007341 name: krt8-krt18 physical interaction comment: keratin and keratin 18 association measured by antibody affinity xref: IntAct:EBI-445615 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0005900 ! K2C8_HUMAN [Term] id: CCO:I0007342 name: h2afx-nbs1-4 physical interaction xref: IntAct:EBI-495255 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:I0007343 name: bcl_xl-bax physical interaction comment: The Bcl_xl protein interacts with the BAX protein xref: IntAct:EBI-516576 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001723 ! BAX_HUMAN relationship: has_participant CCO:B0005901 ! BCLX_HUMAN [Term] id: CCO:I0007346 name: khdrbs1-stat3-1 physical interaction comment: Interaction between Sam68 and STAT3 demonstrated by coimmunoprecipitation xref: IntAct:EBI-518702 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005379 ! STAT3_HUMAN [Term] id: CCO:I0007347 name: khdrbs1-stat3-2 physical interaction comment: Interaction between Sam68 and STAT3 demonstrated by coimmunoprecipitation xref: IntAct:EBI-518705 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005379 ! STAT3_HUMAN [Term] id: CCO:I0007348 name: birc5-casp9 physical interaction comment: The baculoviral IAP repeat-containing protein 5 (Survivin) interacts with the Casp9 (caspase 9) protein xref: IntAct:EBI-518846 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001377 ! BIRC5_HUMAN relationship: has_participant CCO:B0005903 ! CASP9_HUMAN [Term] id: CCO:I0007349 name: cdkn1a-ccne1-5 physical interaction comment: Co IP : bait= p21-CIP1, prey = cyclin E1 xref: IntAct:EBI-519724 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0007350 name: cdk2-rb1-1 phosphorylation comment: phosphorylation of Rb by cdk2 / cyclin E complex xref: IntAct:EBI-520059 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007351 name: cdk2-rb1-2 phosphorylation comment: phosphorylation of Rb by cdk2 / cyclin A complex xref: IntAct:EBI-520074 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007352 name: cables1-tp53-3 physical interaction comment: Interaction between human Cables1 and human p53 demonstrated by coimmunoprecipitation xref: IntAct:EBI-604641 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001994 ! CABL1_HUMAN [Term] id: CCO:I0007353 name: tacc1-aurkb-5 physical interaction comment: Interaction between TACC1 and AURKB1 identified by coimmunoprecipitation xref: IntAct:EBI-624347 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:I0007354 name: tacc1-tdrd7-1 physical interaction comment: Identification of TACC1 interacting partners by Y2H xref: IntAct:EBI-624501 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0005496 ! TDRD7_HUMAN [Term] id: CCO:I0007355 name: hcfc1-many-2 physical interaction comment: interaction cosedimentation of Hcfc1, Sin3A, Ash2 and Sp1 in high-molecular-weight complexes xref: IntAct:EBI-630020 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN relationship: has_participant CCO:B0005485 ! SP1_HUMAN relationship: has_participant CCO:B0005614 ! ASH2L_HUMAN [Term] id: CCO:I0007356 name: pb1-arid2-3 physical interaction comment: copurification by gel-filtration of a baf180 and baf200 containing complex xref: IntAct:EBI-637861 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0001938 ! PB1_HUMAN relationship: has_participant CCO:B0005414 ! SMCA4_HUMAN relationship: has_participant CCO:B0005416 ! SMCE1_HUMAN relationship: has_participant CCO:B0005497 ! ARID2_HUMAN [Term] id: CCO:I0007357 name: sept1-aurkb-1 physical interaction comment: Interaction of Septin1 and Aurora-B identified by Y2H xref: IntAct:EBI-693011 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002011 ! SEPT1_HUMAN relationship: has_participant CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:I0007358 name: blm-terf2-2 physical interaction comment: In vivo Co-IP: bait= BLM, prey =TRF2 xref: IntAct:EBI-710858 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0007359 name: blm-terf2-5 colocalization comment: Colocalization of BLM and TRF2 (TERF2) in VA13/2RA cells xref: IntAct:EBI-710884 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0007360 name: adam17-mad2l1-2 physical interaction xref: IntAct:EBI-78232 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0005712 ! ADA17_HUMAN [Term] id: CCO:I0007361 name: p53-p300-1 physical interaction comment: Interaction between human p53 and human p300 detected by coIP xref: IntAct:EBI-866432 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001728 ! EP300_HUMAN [Term] id: CCO:I0007362 name: p53-jmy-1 physical interaction comment: Interaction between human p53 and human JMY detected by coIP xref: IntAct:EBI-866445 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0040022 ! JMY_HUMAN [Term] id: CCO:I0007363 name: pole3-pole4-3 physical interaction comment: Interaction between POLE1, POLE2, POLE3 and POLE4 identified by coimmunoprecipitation xref: IntAct:EBI-867115 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001724 ! DPOE1_HUMAN relationship: has_participant CCO:B0005904 ! DPOE2_HUMAN [Term] id: CCO:I0007364 name: pole3-pole4-4 physical interaction comment: Interaction between POLE1, POLE3 and POLE4 identified by coimmunoprecipitation xref: IntAct:EBI-867125 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001724 ! DPOE1_HUMAN relationship: has_participant CCO:B0005885 ! DPOE3_HUMAN relationship: has_participant CCO:B0005905 ! DPOE4_HUMAN [Term] id: CCO:I0007365 name: erbb1-erbb3-2 physical interaction comment: Interaction between human erbB1 and erbB3 detected by coIP xref: IntAct:EBI-875494 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005852 ! ERBB3_HUMAN [Term] id: CCO:I0007366 name: erbb1-erbb4-2 physical interaction comment: Interaction between human erbB1 and erbB4 detected by coIP xref: IntAct:EBI-875497 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005906 ! ERBB4_HUMAN [Term] id: CCO:I0007367 name: trrap-brca1 direct interaction comment: Direct interaction determined by pull down. xref: IntAct:EBI-896526 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN [Term] id: CCO:I0007368 name: pcaf-p66a physical interaction xref: IntAct:EBI-923601 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0005907 ! P66A_HUMAN [Term] id: CCO:I0007369 name: pcaf-p66b-1 physical interaction xref: IntAct:EBI-923606 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0005908 ! P66B_HUMAN [Term] id: CCO:I0007372 name: sept5-sept11-1 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between SEPT5 protein and SEPT11 protein xref: IntAct:EBI-958101 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN relationship: has_participant CCO:B0002169 ! SEP11_HUMAN [Term] id: CCO:I0007373 name: sept5-sept8-1 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between SEPT5 protein and SEPT8 protein xref: IntAct:EBI-958139 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002015 ! SEPT8_HUMAN relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN [Term] id: CCO:I0007374 name: bcl10-akt1-4 physical interaction comment: Phosphorylation of BCL10 by Akt1 xref: IntAct:EBI-958972 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001458 ! BCL10_HUMAN relationship: has_participant CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:I0007375 name: kras-rassf2-1 physical interaction xref: IntAct:EBI-960034 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001468 ! RASK_HUMAN relationship: has_participant CCO:B0001646 ! RASF2_HUMAN [Term] id: CCO:I0007376 name: sept11-sept5-1 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between SEPT11 protein and SEPT5 protein xref: IntAct:EBI-962919 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN relationship: has_participant CCO:B0002169 ! SEP11_HUMAN [Term] id: CCO:I0007377 name: cdc25c-chek1-1 phosphorylation comment: Phosphorylation of CDC25C by Chk1 xref: IntAct:EBI-974484 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001359 ! CHK1_HUMAN relationship: has_participant CCO:B0001578 ! MPIP3_HUMAN [Term] id: CCO:I0007379 name: csnk2a1-pml phosphorylation xref: IntAct:EBI-983533 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001570 ! PML_HUMAN relationship: has_participant CCO:B0005428 ! CSK21_HUMAN [Term] id: CCO:I0007380 name: phb-tp53-2 colocalization comment: Colocalisation of Prohibitin and p53 protein xref: IntAct:EBI-985207 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001591 ! PHB_HUMAN [Term] id: CCO:I0007381 name: ubp7-daxx-6 physical interaction xref: IntAct:EBI-992640 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:I0007382 name: shoc2-erbb2ip physical interaction xref: IntAct:EBI-993893 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002059 ! LAP2_HUMAN relationship: has_participant CCO:B0005650 ! SHOC2_HUMAN [Term] id: CCO:I0007383 name: shoc2-erbb2ip-3 physical interaction xref: IntAct:EBI-994100 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002059 ! LAP2_HUMAN relationship: has_participant CCO:B0005650 ! SHOC2_HUMAN [Term] id: CCO:I0007384 name: usp7-tp53 physical interaction xref: IntAct:EBI-996340 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:I0007385 name: usp7-tp53-1 physical interaction xref: IntAct:EBI-996378 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:I0007386 name: usp7-tp53-2 physical interaction xref: IntAct:EBI-996406 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:I0007390 name: sch1-app-4 physical interaction comment: shcA-APP C99 xref: IntAct:EBI-79039 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007391 name: adam15-mad2l2-1 physical interaction xref: IntAct:EBI-77900 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002204 ! MD2L2_HUMAN relationship: has_participant CCO:B0005909 ! ADA15_HUMAN [Term] id: CCO:I0007392 name: cdk4-cdc37 physical interaction comment: Interaction between cdc37 and cdk4 confirmed by Y2H xref: IntAct:EBI-295659 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001819 ! CDC37_HUMAN [Term] id: CCO:I0007393 name: cdk6-cdc37 physical interaction comment: Interaction between cdc37 and cdk6 confirmed by Y2H xref: IntAct:EBI-295662 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001708 ! CDK6_HUMAN relationship: has_participant CCO:B0001819 ! CDC37_HUMAN [Term] id: CCO:I0007394 name: incenp-cbx5-2 physical interaction comment: Interaction detected by GST pull down. xref: IntAct:EBI-307776 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002154 ! INCE_HUMAN relationship: has_participant CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:I0007395 name: cbx5-incenp-1 physical interaction comment: Interaction detected by CoIP. xref: IntAct:EBI-307779 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002154 ! INCE_HUMAN relationship: has_participant CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:I0007396 name: cdc37-hsp90 physical interaction comment: Interaction of Cdc37, Hsp90 and Akt1 demonstrated by western blot xref: IntAct:EBI-296045 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005512 ! AKT1_HUMAN relationship: has_participant CCO:B0005698 ! HS90A_HUMAN [Term] id: CCO:I0007397 name: cdc37-akt1 physical interaction comment: Interaction of Cdc37 and Akt1 demonstrated by coimmunoprecipitation xref: IntAct:EBI-296086 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:I0007398 name: cdc37-akt2 physical interaction comment: Interaction of Cdc37-Akt2 demonstrated by coimmunoprecipitation xref: IntAct:EBI-296109 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005910 ! AKT2_HUMAN [Term] id: CCO:I0007399 name: cdc37-akt3 physical interaction comment: Interaction of Cdc37 and Akt3 demonstrated by coimmunoprecipitation xref: IntAct:EBI-296114 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0005911 ! AKT3_HUMAN [Term] id: CCO:I0007400 name: mcc-nfkbib physical interaction comment: Interaction of MCC1 and IkBbeta xref: IntAct:EBI-352972 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001549 ! CRCM_HUMAN relationship: has_participant CCO:B0005537 ! IKBB_HUMAN [Term] id: CCO:I0007402 name: fance-fanca-1 physical interaction comment: The constituents of the Fanconi anaemia nuclear complex identified by coimmunoprecipitation xref: IntAct:EBI-396813 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001370 ! FANCG_HUMAN relationship: has_participant CCO:B0002109 ! FACD2_HUMAN relationship: has_participant CCO:B0005576 ! FANCE_HUMAN [Term] id: CCO:I0007403 name: fance-fanca-2 physical interaction comment: Components of the Fanconi anaemia complex identified by coimmunoprecipitation xref: IntAct:EBI-396822 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001370 ! FANCG_HUMAN relationship: has_participant CCO:B0005576 ! FANCE_HUMAN [Term] id: CCO:I0007404 name: fance-fancd2-1 physical interaction comment: Interaction between endogenous FANCE and FANCD2 xref: IntAct:EBI-446094 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002109 ! FACD2_HUMAN relationship: has_participant CCO:B0005576 ! FANCE_HUMAN [Term] id: CCO:I0007405 name: cdt1-gmnn-2 physical interaction comment: Interaction between Geminin and CDT1 identified by coimmunoprecipitation xref: IntAct:EBI-456960 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001432 ! GEMI_HUMAN relationship: has_participant CCO:B0002126 ! CDT1_HUMAN [Term] id: CCO:I0007406 name: cdt1-gmnn-3 physical interaction comment: Interaction between Geminin and CDT1 identified by coimmunoprecipitation xref: IntAct:EBI-456966 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001432 ! GEMI_HUMAN relationship: has_participant CCO:B0002126 ! CDT1_HUMAN [Term] id: CCO:I0007407 name: mdm2-mdm4-4 physical interaction comment: MDMX and MDM2 interaction detected by co-immunoprecipitation. xref: IntAct:EBI-399651 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001366 ! MDM4_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0007408 name: map3k4-map2k61 physical interaction comment: Interaction between MAP3K4 and MAP2K6 demonstrated by Y2H xref: IntAct:EBI-448103 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001658 ! MP2K6_HUMAN relationship: has_participant CCO:B0005915 ! M3K4_HUMAN [Term] id: CCO:I0007410 name: c20orf20-epc1-4 physical interaction comment: Interaction detected by comigration through a Suparose 6 gel. xref: IntAct:EBI-399301 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN relationship: has_participant CCO:B0005360 ! MRGBP_HUMAN relationship: has_participant CCO:B0005364 ! RUVB2_HUMAN relationship: has_participant CCO:B0005365 ! DMAP1_HUMAN relationship: has_participant CCO:B0005366 ! ACL6A_HUMAN relationship: has_participant CCO:B0005370 ! MO4L2_HUMAN relationship: has_participant CCO:B0005916 ! EP400_HUMAN relationship: has_participant CCO:B0005917 ! MO4L1_HUMAN [Term] id: CCO:I0007411 name: app-apbb1-6 physical interaction comment: Interacting partners of human APP from brains samples derived from Alzheimers patients xref: IntAct:EBI-960396 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007412 name: krs-rassf2-2 direct interaction xref: IntAct:EBI-960104 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001468 ! RASK_HUMAN relationship: has_participant CCO:B0001646 ! RASF2_HUMAN [Term] id: CCO:I0007413 name: nyd_sp25-tpd53 physical interaction comment: Yeast 2 hybrid analysis reveals interaction between Nyd-SP25 protein and TPD53 protein xref: IntAct:EBI-932183 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0005918 ! TPD55_HUMAN [Term] id: CCO:I0007414 name: cdc73-ctnnb1-1 physical interaction xref: IntAct:EBI-932396 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:I0007415 name: cdc73-ctnnb1-2 physical interaction xref: IntAct:EBI-932408 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:I0007416 name: cdc73-ctnnb1-5 physical interaction xref: IntAct:EBI-932455 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:I0007417 name: p300-tfap2a-6 physical interaction comment: Interaction between human p300 and TFAP2A detected by mammalian two-hybrid xref: IntAct:EBI-937888 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0002091 ! CITE2_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0007418 name: rb1-pa2g4-1 physical interaction xref: IntAct:EBI-925098 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN [Term] id: CCO:I0007419 name: uhrf2-cdk2-2 physical interaction comment: Interaction between UHRF2 (NIRF) and CDK2 identified by GST pulldown xref: IntAct:EBI-625362 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0002054 ! UHRF2_HUMAN [Term] id: CCO:I0007421 name: gpsm2-numa1-2 physical interaction xref: IntAct:EBI-618747 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:I0007422 name: blm-c9orf76-2 physical interaction comment: coimmunoprecipitation: bait = BLM, preys = BLAP75, RPA32, TOPOIIIalpha xref: IntAct:EBI-621447 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001753 ! TOP3A_HUMAN relationship: has_participant CCO:B0005500 ! RFA2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0005919 ! RMI1_HUMAN [Term] id: CCO:I0007423 name: tacc1-aurkb-4 physical interaction comment: Interaction between TACC1 and AURKB1 identified by coimmunoprecipitation xref: IntAct:EBI-624334 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0002040 ! AURKB_HUMAN [Term] id: CCO:I0007424 name: zn655-cdk4-1 physical interaction comment: Interaction between ZN655 (VIK) and CDK4 confirmed by GST pulldown xref: IntAct:EBI-625679 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0005578 ! ZN655_HUMAN [Term] id: CCO:I0007426 name: cdkn2a-huew1-2 physical interaction comment: gst pull down: bait = p14arf, prey = arf-bp1/mule xref: IntAct:EBI-626064 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001966 ! CD2A2_HUMAN relationship: has_participant CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:I0007427 name: c9orf76-blm-2 physical interaction comment: coimmunoprecipitation: bait = BLAP75, preys = BLM, RPA32, TOPOIIIalpha xref: IntAct:EBI-621441 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001753 ! TOP3A_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0005919 ! RMI1_HUMAN [Term] id: CCO:I0007428 name: egfr-pik3c2b-3 direct interaction comment: Interaction of PIK3C2B and EGFR demonstrated by competition binding xref: IntAct:EBI-641269 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005711 ! P3C2B_HUMAN [Term] id: CCO:I0007429 name: egfr-pik3c2b-6 direct interaction comment: Interaction of PIK3C2B and EGFR demonstrated by competition binding xref: IntAct:EBI-641334 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005711 ! P3C2B_HUMAN [Term] id: CCO:I0007434 name: tp53-hipk1-1 physical interaction comment: Interaction between p53 and HIPK1 identified by coimmunoprecipitation xref: IntAct:EBI-692887 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005675 ! HIPK1_HUMAN [Term] id: CCO:I0007436 name: wrn-rad52-1 physical interaction comment: Y2H: bait= RAD52, prey= WRN xref: IntAct:EBI-706461 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007437 name: rad52-rad52-1 physical interaction comment: Y2H: bait= RAD52, prey= RAD52 xref: IntAct:EBI-706466 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001621 ! RAD52_HUMAN [Term] id: CCO:I0007438 name: rad52-rad51-1 physical interaction comment: Y2H: bait= RAD52, prey= RAD51 xref: IntAct:EBI-706470 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007439 name: wrn-rad52-2 direct interaction comment: far-western: bait= WRN, prey= RAD52 xref: IntAct:EBI-706482 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007440 name: wrn-rad52-3 direct interaction comment: far-western: bait= RAD52, prey= WRN xref: IntAct:EBI-706488 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007441 name: wrn-rad52-4 direct interaction comment: CoIP: bait= WRN, prey= RAD52 xref: IntAct:EBI-706506 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007442 name: wrn-rad52-5 direct interaction comment: Co-IP bait= RAD52, prey= WRN xref: IntAct:EBI-706513 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007445 name: bax-bcl2-1 physical interaction comment: Interaction of BAX and BCL2 identified by ELISA xref: IntAct:EBI-706803 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001506 ! BCL2_HUMAN relationship: has_participant CCO:B0001723 ! BAX_HUMAN [Term] id: CCO:I0007447 name: apc-ctbb1 physical interaction comment: Biosensor-Based Micro-Affinity Purification using GST epitope reveals interaction between APC and CTBB1 proteins xref: IntAct:EBI-727740 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0005823 ! K2C1_HUMAN relationship: has_participant CCO:B0005921 ! IGHA1_HUMAN relationship: has_participant CCO:B0005922 ! K1C9_HUMAN [Term] id: CCO:I0007448 name: tgfb2-bapp-1 physical interaction comment: Interaction between transforming growth factor beta and beta amyloid precursor protein detected by chromatography xref: IntAct:EBI-779604 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001687 ! TGFB2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007449 name: bmx-tp53-1 physical interaction comment: Interaction between BMX/Etk and p53 determined by coimmunoprecipitation xref: IntAct:EBI-847661 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005923 ! BMX_HUMAN [Term] id: CCO:I0007451 name: tp53-lap-1 physical interaction comment: Coimmunoprecipitation assay reveals interaction between p53 protein and LAP (full length CCAAT/enhancer-binding protein beta) protein xref: IntAct:EBI-970335 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005514 ! CEBPB_HUMAN [Term] id: CCO:I0007452 name: ttn-obscn-2 physical interaction xref: IntAct:EBI-966795 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005645 ! OBSCN_HUMAN [Term] id: CCO:I0007453 name: gab2-grb2-1 physical interaction comment: Interaction between GAB2, GRB2 and PTN11 xref: IntAct:EBI-975219 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005924 ! GAB2_HUMAN [Term] id: CCO:I0007454 name: brca1-trrap physical interaction comment: Interaction detected by pulldown. xref: IntAct:EBI-896361 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN relationship: has_participant CCO:B0005647 ! GCNL2_HUMAN [Term] id: CCO:I0007455 name: brca1-trrap-1 physical interaction comment: Interaction detected by pull down. xref: IntAct:EBI-896453 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN relationship: has_participant CCO:B0005639 ! MSH6_HUMAN relationship: has_participant CCO:B0005647 ! GCNL2_HUMAN [Term] id: CCO:I0007456 name: cenph_kntc2_1 physical interaction xref: IntAct:EBI-1003699 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0005682 ! CENPH_HUMAN [Term] id: CCO:I0007457 name: eb1-apc-1 physical interaction comment: Interaction between human EB1 and APC detected by pulldown xref: IntAct:EBI-1004194 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0001812 ! MARE1_HUMAN [Term] id: CCO:I0007458 name: eb1-pin2_trf1-1 physical interaction comment: Interaction between human EB1 and PIN2/TRF1 detected by pulldown xref: IntAct:EBI-1004214 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0001812 ! MARE1_HUMAN [Term] id: CCO:I0007459 name: suv39h1-hdac2-3 physical interaction xref: IntAct:EBI-994880 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:I0007460 name: suv39h1-hdac1-3 physical interaction xref: IntAct:EBI-994888 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0007461 name: usp7-tp53-3 direct interaction xref: IntAct:EBI-996806 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:I0007463 name: kntc2-cdca1-2 physical interaction xref: IntAct:EBI-999882 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN [Term] id: CCO:I0007464 name: spbc24-spbc25-1 physical interaction xref: IntAct:EBI-999899 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0007465 name: spbc24-spbc25-2 physical interaction xref: IntAct:EBI-999928 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0007466 name: shoc2-erbb2ip-1 physical interaction xref: IntAct:EBI-993998 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002059 ! LAP2_HUMAN relationship: has_participant CCO:B0005650 ! SHOC2_HUMAN [Term] id: CCO:I0007467 name: tp53-tp53bp2-1 direct interaction comment: P53-53bp2 complex xref: IntAct:EBI-1026207 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN [Term] id: CCO:I0007471 name: ran-rcc1-1 direct interaction comment: Ran-rcc1-so4 complex xref: IntAct:EBI-1031180 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0001693 ! RAN_HUMAN [Term] id: CCO:I0007473 name: kntc2-cdca1-1 physical interaction xref: IntAct:EBI-1101356 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN [Term] id: CCO:I0007474 name: lkb1-strad-1 physical interaction comment: Interaction between STRAD and LKB1 determined by yeast 2-hybrid. xref: IntAct:EBI-1109128 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0001932 ! STRAD_HUMAN [Term] id: CCO:I0007475 name: pms2-mlh1 direct interaction xref: IntAct:EBI-1162573 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001601 ! MLH1_HUMAN relationship: has_participant CCO:B0001669 ! PMS2_HUMAN [Term] id: CCO:I0007476 name: bhlbh2-ube2i-2 physical interaction xref: IntAct:EBI-1164864 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005888 ! BHLH2_HUMAN [Term] id: CCO:I0007477 name: smarca2-sam68 physical interaction xref: IntAct:EBI-1168682 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:I0007478 name: cftr-ebp physical interaction xref: IntAct:EBI-1170380 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:I0007479 name: cftr-atp2a2 physical interaction xref: IntAct:EBI-1171360 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002240 ! EXO1_HUMAN relationship: has_participant CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:I0007481 name: cdn1b-cdk2-3 physical interaction comment: Interaction between CDN1B (p27), Cyclin E1 and CDK2 identified by coimmunoprecipitation xref: IntAct:EBI-1201257 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007484 name: cdn1b-cdk2-4 physical interaction comment: Interaction between CDN1B (p27), Cyclin E1 and CDK2 identified by coimmunoprecipitation xref: IntAct:EBI-1201327 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007485 name: cdn1b-cdk2-5 physical interaction comment: Interaction between CDN1B (p27), Cyclin E1 and CDK2 identified by coimmunoprecipitation xref: IntAct:EBI-1201337 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007486 name: cdkn1b-lyn-1 physical interaction comment: Interaction between CDKN1B (p27) and lyn demonstrated by coimmunoprecipitation xref: IntAct:EBI-1201624 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005457 ! LYN_HUMAN [Term] id: CCO:I0007487 name: cdkn1b-cdk2-1 physical interaction comment: interaction between CDKN1B, CDK2 and CCNA2 demonstrated by gel filtration xref: IntAct:EBI-1201766 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007488 name: cdkn1b-cdk2-5 phosphorylation comment: Phosphorylation of CDKN1B by CDK2 and CCNA2 xref: IntAct:EBI-1201901 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007489 name: ndel1_pafah1b1_1 physical interaction xref: IntAct:EBI-1009436 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001618 ! LIS1_HUMAN relationship: has_participant CCO:B0005926 ! NDEL1_HUMAN [Term] id: CCO:I0007490 name: pafah1b1_ndel1_1 physical interaction xref: IntAct:EBI-1009478 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001618 ! LIS1_HUMAN relationship: has_participant CCO:B0005926 ! NDEL1_HUMAN [Term] id: CCO:I0007491 name: phb-tp53-4 colocalization comment: Colocalisation of Prohibitin and p53 protein xref: IntAct:EBI-1017388 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001591 ! PHB_HUMAN [Term] id: CCO:I0007492 name: esr1-brca1-1 direct interaction xref: IntAct:EBI-1017529 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0007493 name: esr1-brca1-2 direct interaction xref: IntAct:EBI-1024834 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0007494 name: esr1-brca1-3 direct interaction xref: IntAct:EBI-1024855 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0007495 name: esr1-brca1-6 direct interaction xref: IntAct:EBI-1025018 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005652 ! ESR1_HUMAN [Term] id: CCO:I0007496 name: rb1-e2f1 physical interaction xref: IntAct:EBI-1025557 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0007499 name: ccna2-cdk2-4 direct interaction comment: Structure of human thr160-phospho cdk2-cyclin a complexed with the inhibitor nu2058 xref: IntAct:EBI-1034334 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007500 name: ccna2-cdk2-5 direct interaction comment: Structure of human thr160-phospho cdk2-cyclin a complexed with the inhibitor nu6094 xref: IntAct:EBI-1034344 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007501 name: ccna2-cdk2-6 direct interaction comment: Structure of human thr160-phospho cdk2-cyclin a complexed with the inhibitor nu6086 xref: IntAct:EBI-1034354 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007502 name: ccna2-cdk2-7 direct interaction comment: Structure of human thr160-phospho cdk2-cyclin a complexed with the inhibitor nu6102 xref: IntAct:EBI-1034364 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007503 name: egf-egfr-3 direct interaction comment: Structure of the extracellular domain of human epidermal growth factor (egf) receptor in an inactive (low ph) complex with egf. xref: IntAct:EBI-1035794 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001470 ! EGF_HUMAN [Term] id: CCO:I0007504 name: cand1-cul1-5 physical interaction comment: Crystal structure of the cand1-cul1-roc1 complex xref: IntAct:EBI-1040799 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005355 ! CAND1_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN [Term] id: CCO:I0007506 name: fnbp1-dnm2-1 colocalization xref: IntAct:EBI-1111754 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0005386 ! FNBP1_HUMAN [Term] id: CCO:I0007507 name: yeats4-tacc1 physical interaction xref: IntAct:EBI-1151709 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001451 ! YETS4_HUMAN [Term] id: CCO:I0007508 name: tacc1-yeats4-3 colocalization xref: IntAct:EBI-1151783 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001451 ! YETS4_HUMAN [Term] id: CCO:I0007509 name: pin1-nek6-2 physical interaction comment: Interaction between PIN1 and NEK6 identified by coimmunoprecipitation xref: IntAct:EBI-1164681 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0002145 ! NEK6_HUMAN [Term] id: CCO:I0007510 name: pin1-nek6-3 colocalization comment: Interaction between PIN1 and NEK6 identified by colocalisation xref: IntAct:EBI-1164699 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0002145 ! NEK6_HUMAN [Term] id: CCO:I0007511 name: bhlbh2-ube2i-1 physical interaction xref: IntAct:EBI-1164847 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005888 ! BHLH2_HUMAN [Term] id: CCO:I0007512 name: smarca2-sam68-1 physical interaction xref: IntAct:EBI-1168763 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005925 ! SMCA2_HUMAN [Term] id: CCO:I0007513 name: ppp2r5d-cdc25c-1 physical interaction comment: Interaction between PPP2R5D and CDC25c idnetified by cimmunoprecipitation xref: IntAct:EBI-1170666 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001578 ! MPIP3_HUMAN relationship: has_participant CCO:B0005515 ! 2A5D_HUMAN [Term] id: CCO:I0007514 name: h3_peptide-cul4a physical interaction xref: IntAct:EBI-1177834 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005927 ! H33_HUMAN [Term] id: CCO:I0007516 name: egfr-cav1-clca physical interaction xref: IntAct:EBI-1188189 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001584 ! 1433S_HUMAN relationship: has_participant CCO:B0005448 ! CLCA_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN relationship: has_participant CCO:B0005456 ! CAV1_HUMAN relationship: has_participant CCO:B0005457 ! LYN_HUMAN relationship: has_participant CCO:B0005458 ! G3P_HUMAN relationship: has_participant CCO:B0005461 ! S10A9_HUMAN relationship: has_participant CCO:B0005463 ! 4F2_HUMAN [Term] id: CCO:I0007519 name: lck-khdrbs1 physical interaction comment: Interaction between Lck-KHDRBS1 and Sam68 xref: IntAct:EBI-1375 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001490 ! LCK_HUMAN relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:I0007520 name: pard6a-prcki-1 physical interaction comment: Interaction between deletions of PAR-6 and aPKCl/i determined by Y2H. xref: IntAct:EBI-286214 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0007521 name: prcki-pard6a-1 physical interaction comment: Interaction between deletions of aPKCi and PARD6 determined by Y2H. xref: IntAct:EBI-286219 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0005173 ! KPCI_HUMAN [Term] id: CCO:I0007522 name: rad51-rad51-1 physical interaction comment: Interaction detected by CoIP. xref: IntAct:EBI-297242 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007523 name: brap-brca1 physical interaction comment: Interaction of BRAP with BCRA1 detected by Y2H xref: IntAct:EBI-349930 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005471 ! BRAP_HUMAN [Term] id: CCO:I0007524 name: brca1-brap physical interaction comment: BRAP binds to the nuclear localisation signal of BRCA1 - Y2H xref: IntAct:EBI-349934 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005471 ! BRAP_HUMAN [Term] id: CCO:I0007525 name: kpna2-brca1 physical interaction comment: Importin alpha-2 binds to the nuclear localisation signal of BRCA1 - Y2H xref: IntAct:EBI-349937 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001657 ! IMA2_HUMAN [Term] id: CCO:I0007526 name: hmgb1-tp73-1 physical interaction comment: Direct interactions between HMGB1 and p73-alpha as revealed by pull-down assay. xref: IntAct:EBI-389651 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001374 ! P73_HUMAN relationship: has_participant CCO:B0005929 ! HMGB1_HUMAN [Term] id: CCO:I0007527 name: abi1-abl1-1 physical interaction xref: IntAct:EBI-389880 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005703 ! ABI1_HUMAN [Term] id: CCO:I0007529 name: hif1a-ep300-2 physical interaction comment: Interaction of HIF1A with EP300 detected by mammalian two-hybrid system. xref: IntAct:EBI-447490 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:I0007530 name: map3k4-gadd45 physical interaction comment: GADD45/MAP3K4/MAP2K6 interaction identified by Y3H xref: IntAct:EBI-448179 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001552 ! GA45A_HUMAN relationship: has_participant CCO:B0001658 ! MP2K6_HUMAN relationship: has_participant CCO:B0005915 ! M3K4_HUMAN [Term] id: CCO:I0007531 name: map3k4-gadd45-2 physical interaction comment: GADD45/MAP3K4/MAP2K6 interaction identified by Y3H xref: IntAct:EBI-448183 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001424 ! GA45B_HUMAN relationship: has_participant CCO:B0001658 ! MP2K6_HUMAN relationship: has_participant CCO:B0005915 ! M3K4_HUMAN [Term] id: CCO:I0007532 name: map3k4-gadd45-3 physical interaction comment: GADD45/MAP3K4/MAP2K6 interaction identified by Y3H xref: IntAct:EBI-448198 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001658 ! MP2K6_HUMAN relationship: has_participant CCO:B0005411 ! GA45G_HUMAN relationship: has_participant CCO:B0005915 ! M3K4_HUMAN [Term] id: CCO:I0007533 name: cdt1-cdk2-1 physical interaction comment: Interaction between CTD1 and cyclin-dependent protein kinases demonstrated by coimmunoprecipitation xref: IntAct:EBI-457093 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0002126 ! CDT1_HUMAN [Term] id: CCO:I0007534 name: sirt2-pcaf-1 physical interaction comment: Interaction between SIRT2 and PCAF demonstrated by CoIP. xref: IntAct:EBI-477370 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN [Term] id: CCO:I0007535 name: sirt2-pcaf-2 physical interaction comment: Interaction between SIRT2 and PCAF demonstrated by CoIP. xref: IntAct:EBI-477484 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN [Term] id: CCO:I0007536 name: sirt2-pcaf-myod1-1 physical interaction comment: Interaction between SIRT2, PCAF and MYOD1 detected by CoIP. xref: IntAct:EBI-488593 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0005705 ! MYOD1_HUMAN [Term] id: CCO:I0007537 name: orc1-skp2-1 physical interaction comment: Interaction of hORC1 with SKP2 xref: IntAct:EBI-492406 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0005352 ! ORC1_HUMAN [Term] id: CCO:I0007538 name: h2afx-nbs1-5 physical interaction xref: IntAct:EBI-495266 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:I0007539 name: orc2-mcm3-1 physical interaction comment: Interaction between Orc2 and Mcm3 by coimmunoprecipitation xref: IntAct:EBI-515223 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0005353 ! ORC2_HUMAN [Term] id: CCO:I0007540 name: mcm3-mcm5-1 physical interaction comment: Immunoprecipitation of an Mcm protein complex xref: IntAct:EBI-515228 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0001588 ! MCM5_HUMAN relationship: has_participant CCO:B0005353 ! ORC2_HUMAN [Term] id: CCO:I0007541 name: mcm3-mcm5-2 physical interaction comment: Immunoprecipitation of an Mcm protein complex xref: IntAct:EBI-515234 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0001588 ! MCM5_HUMAN [Term] id: CCO:I0007542 name: mcm4-mcm6-1 physical interaction comment: Mcm4-Mcm6-Mcm7 complex identified by co-immunoprecipitation xref: IntAct:EBI-515243 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:I0007544 name: cdk4-ccnd1-1 physical interaction comment: co-IP: bait = cyclin D1, prey = cdk4 xref: IntAct:EBI-519187 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN [Term] id: CCO:I0007545 name: cdk4-ccnd1-2 physical interaction comment: co-IP: bait = cdk4, prey = cyclin D1 xref: IntAct:EBI-519196 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN [Term] id: CCO:I0007546 name: cdk4-cdkn1c-1 physical interaction comment: co-IP: bait = cdk4, prey = KIP2 xref: IntAct:EBI-519276 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001640 ! CDN1C_HUMAN [Term] id: CCO:I0007547 name: cdk4-cdkn1b-1 physical interaction comment: co-IP: bait = cdk4, prey = KIP1 xref: IntAct:EBI-519297 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007548 name: cdk4-cdkn1a-1 physical interaction comment: co-IP: bait= p21-CIP1, prey = cdk4 xref: IntAct:EBI-519303 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0007549 name: cdk4-ccnd3-1 physical interaction comment: co-IP: bait = cdk4, prey = cyclin D3 xref: IntAct:EBI-519309 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001574 ! CCND3_HUMAN [Term] id: CCO:I0007550 name: cdk4-ccnd3-2 physical interaction comment: co-IP: bait = cyclin D3, prey = cdk4 xref: IntAct:EBI-519350 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001574 ! CCND3_HUMAN [Term] id: CCO:I0007551 name: dapk-erk-2 physical interaction comment: Yeast-2-hybrid reveals interaction between death-associated protein kinase 1protein and the mitogen-activated protein kinase 3 protein xref: IntAct:EBI-525623 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001560 ! MK03_HUMAN relationship: has_participant CCO:B0005482 ! DAPK1_HUMAN [Term] id: CCO:I0007552 name: rent1-stau-1 physical interaction xref: IntAct:EBI-536589 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0005483 ! STAU1_HUMAN [Term] id: CCO:I0007554 name: araf-pbk-1 physical interaction comment: Y2H: bait = A-Raf ,prey = TOPK/BPK-MPAKK-like protein kinase cap site form 2 xref: IntAct:EBI-537076 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002045 ! TOPK_HUMAN relationship: has_participant CCO:B0005708 ! ARAF_HUMAN [Term] id: CCO:I0007555 name: araf-pbk-2 physical interaction comment: Y2H: bait = A-Raf ,prey = TOPK/BPK-MPAKK-like protein kinase cap site form 2 xref: IntAct:EBI-537146 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002045 ! TOPK_HUMAN relationship: has_participant CCO:B0005708 ! ARAF_HUMAN [Term] id: CCO:I0007556 name: cdn1b-kpna3-1 physical interaction comment: FLAG pull-down : bait = p27 KIP1, prey= importin alpha 3 xref: IntAct:EBI-540571 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005931 ! IMA3_HUMAN [Term] id: CCO:I0007557 name: cdn1b-kpna3-2 physical interaction comment: FLAG pull-down : bait = p27 KIP1, prey= importin alpha 3, prey = importin beta xref: IntAct:EBI-540594 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005931 ! IMA3_HUMAN [Term] id: CCO:I0007558 name: cdn1b-kpna5-1 physical interaction comment: FLAG pull-down : bait = p27 KIP1, prey= importin alpha 5, prey = importin beta xref: IntAct:EBI-540611 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005697 ! IMA5_HUMAN [Term] id: CCO:I0007559 name: cdn1b-kpna5-2 physical interaction comment: FLAG pull-down : bait = p27 KIP1, prey= importin alpha 5 xref: IntAct:EBI-540624 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005697 ! IMA5_HUMAN [Term] id: CCO:I0007560 name: cdn1b-kpna5-3 physical interaction comment: in vivo Co-IP : bait = p27 KIP1, prey= importin alpha 5 xref: IntAct:EBI-540640 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005697 ! IMA5_HUMAN [Term] id: CCO:I0007561 name: hcfc1-sin3a-3 physical interaction comment: Immunoblot (co-ip) of interaction between hcfc1 basic region and sin3a xref: IntAct:EBI-540858 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN [Term] id: CCO:I0007562 name: hcfc1-ash2l-2 physical interaction comment: Immunoblot (co-ip) of interaction between the kelch domain of hcfc1 and ash2l xref: IntAct:EBI-540883 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005614 ! ASH2L_HUMAN [Term] id: CCO:I0007564 name: ubl5-sart1-1 physical interaction comment: Interaction between human ubl5 (hub1 homolog) and sart1 (snu66 homolog) via classical two hybrid xref: IntAct:EBI-607767 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001388 ! SNUT1_HUMAN relationship: has_participant CCO:B0005932 ! UBL5_HUMAN [Term] id: CCO:I0007565 name: hcfc1-zbtb17-1 physical interaction comment: Y2H of interaction between hcfc1 and zbtb17 (Miz1) xref: IntAct:EBI-621532 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN [Term] id: CCO:I0007566 name: tacc1-chtog-6 direct interaction comment: Regions of interaction between TACC1 and chTOG identified by GST pulldown xref: IntAct:EBI-624701 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001772 ! CKAP5_HUMAN [Term] id: CCO:I0007567 name: tacc1-tdrd7-7 physical interaction comment: Identification of regions of TACC1 which interact with TDRD7 (TRAP) by GST pulldown xref: IntAct:EBI-624727 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0005496 ! TDRD7_HUMAN [Term] id: CCO:I0007568 name: tp53-huew1-1 physical interaction comment: gst pull down: bait = tp53, prey = arf-bp1/mule xref: IntAct:EBI-626140 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:I0007569 name: brg1-baf200-2 physical interaction comment: coIP: bait = brg1, preys = baf200, baf180, baf170, baf155, baf60a, baf53, snf5, actin xref: IntAct:EBI-638040 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0001938 ! PB1_HUMAN relationship: has_participant CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:I0007570 name: egfr-pik3c2b-4 physical interaction comment: Interaction of PIK3C2B and EGFR demonstrated by GST-pulldown xref: IntAct:EBI-641307 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005711 ! P3C2B_HUMAN [Term] id: CCO:I0007571 name: ttn-actn2-1 physical interaction comment: Interaction of titin and alpha-actinin detected by yeast two hybrid. xref: IntAct:EBI-696133 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005642 ! ACTN2_HUMAN [Term] id: CCO:I0007572 name: pten-mast3-2 physical interaction comment: Interaction between human PTEN and Mast3 identified by Y2H betagalactosidase assay xref: IntAct:EBI-696418 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0005499 ! MAST3_HUMAN [Term] id: CCO:I0007573 name: wrn-terf2-8 direct interaction comment: ELISA: bait= WRM, prey = TRF2 (TERF2) xref: IntAct:EBI-706740 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007574 name: blm-terf2-3 direct interaction comment: ELISA: bait= BLM, prey = TRF2 (TERF2) xref: IntAct:EBI-706749 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0007575 name: g22p1-centd2-1 physical interaction comment: Interaction between G22P1 and CENTD2 detected by anti protein A antibodies COIP xref: IntAct:EBI-709999 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002052 ! CEND2_HUMAN relationship: has_participant CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:I0007576 name: htatip-dleu1-1 physical interaction comment: Interaction between HTATIP and DLEU1 detected by anti protein A antibodies COIP xref: IntAct:EBI-710053 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0005351 ! TIP60_HUMAN [Term] id: CCO:I0007577 name: tp53-btbd2-1 physical interaction comment: Interaction between TP53 and BTBD2 determined by Protein A CoIP xref: IntAct:EBI-710087 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005933 ! BTBD2_HUMAN [Term] id: CCO:I0007578 name: p53-wrn-1 direct interaction comment: ELISA: bait= P53, prey =WRN xref: IntAct:EBI-711124 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007579 name: p53-wrn-2 direct interaction comment: ELISA: bait=WRN , prey =P53 xref: IntAct:EBI-711129 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005358 ! WRN_HUMAN [Term] id: CCO:I0007581 name: p53-rpa1-8 physical interaction comment: ELISA: bait = human Replication Protein A RPA70 (70kDa subunit), prey =P53 xref: IntAct:EBI-711148 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001562 ! RFA1_HUMAN [Term] id: CCO:I0007582 name: bcl6-hdac4 physical interaction comment: Coimmunoprecipitaion reveals interaction between BCL6, HDAC4, SMRT,PKC and WNK4 xref: IntAct:EBI-766553 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001603 ! BCL6_HUMAN relationship: has_participant CCO:B0001679 ! HDAC4_HUMAN relationship: has_participant CCO:B0005553 ! NCOR2_HUMAN relationship: has_participant CCO:B0005934 ! WNK4_HUMAN relationship: has_participant CCO:B0005935 ! PKCB1_HUMAN [Term] id: CCO:I0007583 name: hdac4-bcl6 physical interaction comment: Coimmunoprecipitaion reveals interaction between HDAC4 and BCL6 proteins xref: IntAct:EBI-766559 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001603 ! BCL6_HUMAN relationship: has_participant CCO:B0001679 ! HDAC4_HUMAN [Term] id: CCO:I0007584 name: pkc-bcl6 physical interaction comment: Coimmunoprecipitaion reveals interaction between PKC and BCL6 xref: IntAct:EBI-766565 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001603 ! BCL6_HUMAN relationship: has_participant CCO:B0005935 ! PKCB1_HUMAN [Term] id: CCO:I0007585 name: tgfb2-bapp-4 physical interaction comment: Interaction between transforming growth factor beta and beta amyloid precursor protein detected by chromatography xref: IntAct:EBI-779627 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001687 ! TGFB2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007586 name: hd52-hd53-2 physical interaction comment: Interaction between human D52 and human D53 detected by Y2H xref: IntAct:EBI-782712 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0005373 ! TPD52_HUMAN [Term] id: CCO:I0007587 name: fancg-fancf-1 physical interaction comment: Interaction of FANCA, FANCG and FANCF detected by CoIP. xref: IntAct:EBI-81620 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001370 ! FANCG_HUMAN relationship: has_participant CCO:B0005323 ! FANCA_HUMAN relationship: has_participant CCO:B0005936 ! FANCF_HUMAN [Term] id: CCO:I0007588 name: pold1-pold2-1 physical interaction comment: Assembly of DNA polymerase delta identifed by column chromotography xref: IntAct:EBI-864998 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005882 ! DPOD4_HUMAN relationship: has_participant CCO:B0005883 ! DPOD2_HUMAN relationship: has_participant CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:I0007589 name: pold1-pold2-3 physical interaction comment: Assembly of DNA polymerase delta subunits 1 and 2 identifed by column chromotography xref: IntAct:EBI-865018 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005883 ! DPOD2_HUMAN [Term] id: CCO:I0007590 name: pold1-pold4-1 direct interaction comment: Assembly of DNA polymerase delta subunits 1 and 4 identifed by column chromotography xref: IntAct:EBI-865140 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005882 ! DPOD4_HUMAN [Term] id: CCO:I0007591 name: erbb1-erbb2-1 physical interaction comment: Interaction between human erbB1 and erbB2 detected by coIP xref: IntAct:EBI-875446 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005540 ! ERBB2_HUMAN [Term] id: CCO:I0007592 name: erbb1-erbb3-1 physical interaction comment: Interaction between human erbB1 and erbB3 detected by coIP xref: IntAct:EBI-875451 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005852 ! ERBB3_HUMAN [Term] id: CCO:I0007593 name: erbb1-erbb4-1 physical interaction comment: Interaction between human erbB1 and erbB4 detected by coIP xref: IntAct:EBI-875456 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005906 ! ERBB4_HUMAN [Term] id: CCO:I0007594 name: brca1-trrap-4 direct interaction comment: Interaction detected by far western. xref: IntAct:EBI-896511 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN [Term] id: CCO:I0007595 name: brca1-trrap-5 physical interaction comment: Interaction detected by pulldown. xref: IntAct:EBI-896576 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN relationship: has_participant CCO:B0005647 ! GCNL2_HUMAN [Term] id: CCO:I0007596 name: brca1-trrap-7 physical interaction comment: Interaction detected by sucrose gradient. xref: IntAct:EBI-896617 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001431 ! SUPT3_HUMAN relationship: has_participant CCO:B0001433 ! TAD3L_HUMAN relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005350 ! TRRAP_HUMAN relationship: has_participant CCO:B0005647 ! GCNL2_HUMAN relationship: has_participant CCO:B0005937 ! TAF10_HUMAN relationship: has_participant CCO:B0005938 ! TAF9_HUMAN [Term] id: CCO:I0007598 name: skp2-skp1 physical interaction xref: IntAct:EBI-914687 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001575 ! WEE1_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0005940 ! Q9UC27_HUMAN [Term] id: CCO:I0007599 name: fbxw11-skp1 physical interaction xref: IntAct:EBI-914707 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001575 ! WEE1_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0005941 ! FBW1B_HUMAN [Term] id: CCO:I0007600 name: btrc-skp1-1 physical interaction xref: IntAct:EBI-914716 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001575 ! WEE1_HUMAN relationship: has_participant CCO:B0005633 ! FBW1A_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0007601 name: btrc-wee1 physical interaction xref: IntAct:EBI-914868 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001575 ! WEE1_HUMAN relationship: has_participant CCO:B0005633 ! FBW1A_HUMAN [Term] id: CCO:I0007602 name: fbxw11-wee1 physical interaction xref: IntAct:EBI-914887 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001575 ! WEE1_HUMAN relationship: has_participant CCO:B0005941 ! FBW1B_HUMAN [Term] id: CCO:I0007603 name: eif4g2-eif4a1-2 direct interaction comment: Interaction between eIF4G2 and eIF4A1 demonstrated by NMR xref: IntAct:EBI-928036 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001699 ! IF4G2_HUMAN relationship: has_participant CCO:B0005679 ! IF4A1_HUMAN [Term] id: CCO:I0007604 name: app-nsf-1 physical interaction comment: Interacting partners of human APP from brains samples derived from Alzheimers patients xref: IntAct:EBI-960166 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007611 name: ubqln4-stmn1 physical interaction xref: IntAct:EBI-950386 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001528 ! STMN1_HUMAN relationship: has_participant CCO:B0005619 ! UBQL4_HUMAN [Term] id: CCO:I0007613 name: aptx-cntrob physical interaction xref: IntAct:EBI-950638 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001961 ! CNTRB_HUMAN relationship: has_participant CCO:B0005943 ! APTX_HUMAN [Term] id: CCO:I0007614 name: atn1-jag2 physical interaction xref: IntAct:EBI-950818 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002245 ! JAG2_HUMAN relationship: has_participant CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:I0007615 name: atn1-jag2-1 physical interaction xref: IntAct:EBI-951004 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002245 ! JAG2_HUMAN relationship: has_participant CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:I0007616 name: atn1-siah1 physical interaction xref: IntAct:EBI-951208 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001946 ! SIAH1_HUMAN relationship: has_participant CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:I0007617 name: atn1-siah2 physical interaction xref: IntAct:EBI-951214 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001384 ! SIAH2_HUMAN relationship: has_participant CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:I0007618 name: atn1-spag5 physical interaction xref: IntAct:EBI-951220 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002058 ! SPAG5_HUMAN relationship: has_participant CCO:B0005944 ! ATN1_HUMAN [Term] id: CCO:I0007619 name: atxn1-btg3 physical interaction xref: IntAct:EBI-951262 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001778 ! BTG3_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0007620 name: atxn1-apbb1 physical interaction xref: IntAct:EBI-951526 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0007621 name: atxn1-apbb1-1 physical interaction xref: IntAct:EBI-951736 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0007622 name: atxn1-ube2i physical interaction xref: IntAct:EBI-952078 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0007623 name: atxn1-btg3-1 physical interaction xref: IntAct:EBI-952204 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001778 ! BTG3_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0007624 name: atxn1-dctn3 physical interaction xref: IntAct:EBI-952228 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001440 ! DCTN3_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0007625 name: atxn1-gspt1 physical interaction xref: IntAct:EBI-952276 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001520 ! ERF3A_HUMAN relationship: has_participant CCO:B0005425 ! ATX1_HUMAN [Term] id: CCO:I0007626 name: atxn7-tp53bp2 physical interaction xref: IntAct:EBI-952468 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0005945 ! ATX7_HUMAN [Term] id: CCO:I0007627 name: atxn7l3-sertad1 physical interaction xref: IntAct:EBI-952504 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002202 ! SRTD1_HUMAN relationship: has_participant CCO:B0005946 ! Q8IY68_HUMAN [Term] id: CCO:I0007629 name: gfi1-prkcabp physical interaction xref: IntAct:EBI-952774 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002083 ! GFI1_HUMAN relationship: has_participant CCO:B0005947 ! PICK1_HUMAN [Term] id: CCO:I0007630 name: gfi1b-actn1 physical interaction xref: IntAct:EBI-952780 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005948 ! ACTN1_HUMAN [Term] id: CCO:I0007631 name: gfi1b-agrn physical interaction xref: IntAct:EBI-952786 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005949 ! AGRIN_HUMAN [Term] id: CCO:I0007632 name: gfi1b-becn1 physical interaction xref: IntAct:EBI-952792 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005950 ! BECN1_HUMAN [Term] id: CCO:I0007633 name: gfi1b-brca1 physical interaction xref: IntAct:EBI-952798 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN [Term] id: CCO:I0007634 name: gfi1b-bre physical interaction xref: IntAct:EBI-952804 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005951 ! BRE_HUMAN [Term] id: CCO:I0007635 name: gfi1b-c20orf12 physical interaction xref: IntAct:EBI-952810 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005952 ! CT012_HUMAN [Term] id: CCO:I0007636 name: gfi1b-cenpb physical interaction xref: IntAct:EBI-952816 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005431 ! CENPB_HUMAN [Term] id: CCO:I0007637 name: gfi1b-cenpj physical interaction xref: IntAct:EBI-952822 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005426 ! CENPJ_HUMAN [Term] id: CCO:I0007638 name: gfi1b-dkfzp586m1819 physical interaction xref: IntAct:EBI-952828 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005953 ! Q8NDD3_HUMAN [Term] id: CCO:I0007639 name: gfi1b-dtna physical interaction xref: IntAct:EBI-952834 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005954 ! DTNA_HUMAN [Term] id: CCO:I0007640 name: gfi1b-efemp1 physical interaction xref: IntAct:EBI-952840 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005955 ! FBLN3_HUMAN [Term] id: CCO:I0007641 name: gfi1b-efemp2 physical interaction xref: IntAct:EBI-952846 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005215 ! FBLN4_HUMAN [Term] id: CCO:I0007642 name: gfi1b-megf6 physical interaction xref: IntAct:EBI-952852 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005956 ! MEGF6_HUMAN [Term] id: CCO:I0007643 name: gfi1b-megf8 physical interaction xref: IntAct:EBI-952858 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005957 ! MEGF8_HUMAN [Term] id: CCO:I0007644 name: gfi1b-egfl7 physical interaction xref: IntAct:EBI-952864 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005958 ! EGFL7_HUMAN [Term] id: CCO:I0007645 name: gfi1b-fbln1 physical interaction xref: IntAct:EBI-952870 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005959 ! FBLN1_HUMAN [Term] id: CCO:I0007646 name: gfi1b-grip2 physical interaction xref: IntAct:EBI-952882 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005960 ! GRIP2_HUMAN [Term] id: CCO:I0007647 name: gfi1b-grn physical interaction xref: IntAct:EBI-952888 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005961 ! GRN_HUMAN [Term] id: CCO:I0007648 name: gfi1b-hecw1 physical interaction xref: IntAct:EBI-952894 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005962 ! HECW1_HUMAN [Term] id: CCO:I0007649 name: gfi1b-hgs physical interaction xref: IntAct:EBI-952900 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005280 ! HGS_HUMAN [Term] id: CCO:I0007650 name: gfi1b-hnrpk physical interaction xref: IntAct:EBI-952906 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005235 ! HNRPK_HUMAN [Term] id: CCO:I0007651 name: gfi1b-hom_tes_103 physical interaction xref: IntAct:EBI-952912 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005963 ! Q6P593_HUMAN [Term] id: CCO:I0007652 name: gfi1b-hspg2 physical interaction xref: IntAct:EBI-952918 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005964 ! PGBM_HUMAN [Term] id: CCO:I0007653 name: gfi1b-jag2-1 physical interaction xref: IntAct:EBI-952924 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0002245 ! JAG2_HUMAN [Term] id: CCO:I0007654 name: gfi1b-begain physical interaction xref: IntAct:EBI-952936 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005626 ! BEGIN_HUMAN [Term] id: CCO:I0007655 name: gfi1b-anks3 physical interaction xref: IntAct:EBI-952942 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005965 ! ANKS3_HUMAN [Term] id: CCO:I0007656 name: gfi1b-kif17 physical interaction xref: IntAct:EBI-952948 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005966 ! KIF17_HUMAN [Term] id: CCO:I0007657 name: gfi1b-lamb1 physical interaction xref: IntAct:EBI-952954 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005967 ! LAMB1_HUMAN [Term] id: CCO:I0007658 name: gfi1b-lzts2 physical interaction xref: IntAct:EBI-952966 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN [Term] id: CCO:I0007659 name: gfi1b-matr3 physical interaction xref: IntAct:EBI-952972 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005968 ! MATR3_HUMAN [Term] id: CCO:I0007660 name: gfi1b-mid2 physical interaction xref: IntAct:EBI-952978 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005969 ! TRIM1_HUMAN [Term] id: CCO:I0007661 name: gfi1b-mon1a physical interaction xref: IntAct:EBI-952984 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005970 ! MON1A_HUMAN [Term] id: CCO:I0007662 name: gfi1b-myh14 physical interaction xref: IntAct:EBI-952990 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005971 ! MYH14_HUMAN [Term] id: CCO:I0007663 name: gfi1b-nelf physical interaction xref: IntAct:EBI-953002 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005972 ! NELF_HUMAN [Term] id: CCO:I0007664 name: gfi1b-nell1 physical interaction xref: IntAct:EBI-953008 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005973 ! NELL1_HUMAN [Term] id: CCO:I0007665 name: gfi1b-nell2-1 physical interaction xref: IntAct:EBI-953014 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005427 ! NELL2_HUMAN [Term] id: CCO:I0007666 name: gfi1b-notch1 physical interaction xref: IntAct:EBI-953020 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005974 ! NOTC1_HUMAN [Term] id: CCO:I0007667 name: gfi1b-pde4dip physical interaction xref: IntAct:EBI-953026 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005975 ! Q5TB27_HUMAN [Term] id: CCO:I0007668 name: gfi1b-enh physical interaction xref: IntAct:EBI-953032 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005976 ! PDLI5_HUMAN [Term] id: CCO:I0007669 name: gfi1b-pdzk4 physical interaction xref: IntAct:EBI-953038 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005977 ! PDZD4_HUMAN [Term] id: CCO:I0007670 name: gfi1b-phc2 physical interaction xref: IntAct:EBI-953044 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005978 ! PHC2_HUMAN [Term] id: CCO:I0007671 name: gfi1b-prkcabp physical interaction xref: IntAct:EBI-953050 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005947 ! PICK1_HUMAN [Term] id: CCO:I0007672 name: gfi1b-rab11fip4 physical interaction xref: IntAct:EBI-953056 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005979 ! RFIP4_HUMAN [Term] id: CCO:I0007673 name: gfi1b-rchy1 physical interaction xref: IntAct:EBI-953062 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005980 ! ZN363_HUMAN [Term] id: CCO:I0007674 name: gfi1b-rfp physical interaction xref: IntAct:EBI-953068 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005981 ! TRI27_HUMAN [Term] id: CCO:I0007675 name: gfi1b-rint1 physical interaction xref: IntAct:EBI-953074 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0001909 ! RINT1_HUMAN [Term] id: CCO:I0007676 name: gfi1b-rnf31 physical interaction xref: IntAct:EBI-953080 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005982 ! RNF31_HUMAN [Term] id: CCO:I0007678 name: gfi1b-taf1 physical interaction xref: IntAct:EBI-953092 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001543 ! TAF1_HUMAN relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN [Term] id: CCO:I0007679 name: gfi1b-tmf1 physical interaction xref: IntAct:EBI-953104 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005984 ! TMF1_HUMAN [Term] id: CCO:I0007680 name: gfi1b-trip6 physical interaction xref: IntAct:EBI-953110 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005985 ! TRIP6_HUMAN [Term] id: CCO:I0007681 name: gfi1b-vsnl1 physical interaction xref: IntAct:EBI-953122 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005986 ! VISL1_HUMAN [Term] id: CCO:I0007682 name: gfi1b-actn1-1 physical interaction xref: IntAct:EBI-953134 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005948 ! ACTN1_HUMAN [Term] id: CCO:I0007683 name: gfi1b-aes physical interaction xref: IntAct:EBI-953140 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005987 ! AES_HUMAN [Term] id: CCO:I0007684 name: gfi1b-atxn2 physical interaction xref: IntAct:EBI-953146 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005988 ! ATX2_HUMAN [Term] id: CCO:I0007685 name: gfi1b-dnaja3 physical interaction xref: IntAct:EBI-953152 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005818 ! DNJA3_HUMAN [Term] id: CCO:I0007686 name: gfi1b-efemp1-1 physical interaction xref: IntAct:EBI-953158 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005955 ! FBLN3_HUMAN [Term] id: CCO:I0007687 name: gfi1b-efemp2-1 physical interaction xref: IntAct:EBI-953164 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005215 ! FBLN4_HUMAN [Term] id: CCO:I0007688 name: gfi1b-fbln5 physical interaction xref: IntAct:EBI-953170 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005989 ! FBLN5_HUMAN [Term] id: CCO:I0007689 name: gfi1b-jub physical interaction xref: IntAct:EBI-953176 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0026254 ! JUB_HUMAN [Term] id: CCO:I0007690 name: gfi1b-prkcabp-1 physical interaction xref: IntAct:EBI-953182 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005947 ! PICK1_HUMAN [Term] id: CCO:I0007691 name: gfi1b-psma3 physical interaction xref: IntAct:EBI-953188 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005991 ! PSA3_HUMAN [Term] id: CCO:I0007692 name: gfi1b-traf1 physical interaction xref: IntAct:EBI-953194 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005992 ! TRAF1_HUMAN [Term] id: CCO:I0007693 name: gfi1b-trip6-1 physical interaction xref: IntAct:EBI-953200 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005985 ! TRIP6_HUMAN [Term] id: CCO:I0007694 name: gfi1b-txndc11 physical interaction xref: IntAct:EBI-953206 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: has_participant CCO:B0005993 ! TXD11_HUMAN [Term] id: CCO:I0007696 name: atm-cabl-1 physical interaction comment: Interaction between human ATM and c-Abl detected by coIP xref: IntAct:EBI-1005980 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:I0007697 name: atm-pin2_trf1-1 physical interaction comment: Interaction between human ATM and Pin2/TRF1 detected by coIP xref: IntAct:EBI-1006035 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:I0007698 name: pin2_trf1-atm-2 physical interaction comment: Interaction between human Pin2/TRF1 and ATM detected by coIP xref: IntAct:EBI-1006045 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0001750 ! ATM_HUMAN [Term] id: CCO:I0007707 name: tp53-nfya physical interaction xref: IntAct:EBI-1025792 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005382 ! NFYB_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN [Term] id: CCO:I0007709 name: bmp2-bmpr1a-2 direct interaction comment: Structural refinement of the complex of bone morphogenetic protein 2 and its type ia receptor xref: IntAct:EBI-1038504 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001515 ! BMP2_HUMAN relationship: has_participant CCO:B0005437 ! BMR1A_HUMAN [Term] id: CCO:I0007711 name: wapl-cspg6-4 physical interaction xref: IntAct:EBI-1175658 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001829 ! PDS5A_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:I0007712 name: wapl-cspg6-5 physical interaction xref: IntAct:EBI-1175670 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001829 ! PDS5A_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0002004 ! STAG1_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:I0007713 name: wapl-cspg6-6 physical interaction xref: IntAct:EBI-1175685 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001829 ! PDS5A_HUMAN relationship: has_participant CCO:B0002004 ! STAG1_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:I0007714 name: wapl-cspg6-7 physical interaction xref: IntAct:EBI-1175700 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001829 ! PDS5A_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:I0007715 name: wapl-cspg6-9 physical interaction xref: IntAct:EBI-1175727 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001829 ! PDS5A_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0002004 ! STAG1_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0005721 ! WAPL_HUMAN [Term] id: CCO:I0007716 name: cul4b-ddb1-1 physical interaction xref: IntAct:EBI-1176157 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005656 ! DTL_HUMAN relationship: has_participant CCO:B0005658 ! DDB2_HUMAN relationship: has_participant CCO:B0005660 ! RBBP5_HUMAN relationship: has_participant CCO:B0005687 ! GRWD1_HUMAN relationship: has_participant CCO:B0005688 ! WDR82_HUMAN relationship: has_participant CCO:B0005689 ! WDR26_HUMAN relationship: has_participant CCO:B0005996 ! WDR57_HUMAN relationship: has_participant CCO:B0005997 ! WDR76_HUMAN relationship: has_participant CCO:B0005998 ! WD51B_HUMAN relationship: has_participant CCO:B0005999 ! WDR61_HUMAN relationship: has_participant CCO:B0006000 ! WDR5B_HUMAN relationship: has_participant CCO:B0006001 ! RFWD2_HUMAN [Term] id: CCO:I0007717 name: cul4b-wdr5 physical interaction xref: IntAct:EBI-1176554 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0005615 ! WDR5_HUMAN [Term] id: CCO:I0007719 name: sds3-brms1 physical interaction comment: BRMS1 coimmunoprecipitates with SDS3 in COS7 cell lysate xref: IntAct:EBI-1200021 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005694 ! SDS3_HUMAN [Term] id: CCO:I0007720 name: dnajb6-brms1 physical interaction comment: BRMS1 coimmunoprecipitates with MRJ (DNAJB6) in COS7 cell lysate xref: IntAct:EBI-1200029 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005696 ! DNJB6_HUMAN [Term] id: CCO:I0007721 name: nmi-brms1 physical interaction comment: BRMS1 coimmunoprecipitates with NMI in COS7 cell lysate xref: IntAct:EBI-1200215 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005695 ! NMI_HUMAN [Term] id: CCO:I0007722 name: smarce1-brms1 physical interaction comment: BRMS1 coimmunoprecipitates with BAF57 (SMARCE1) in COS7 cell lysate xref: IntAct:EBI-1200228 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005416 ! SMCE1_HUMAN [Term] id: CCO:I0007723 name: brca2-rad51-4 physical interaction comment: Interaction of deletion constructs of BRCA2 with RAD51 determined by GST-pull down. xref: IntAct:EBI-298264 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007726 name: h3fa-suv39h1 physical interaction xref: IntAct:EBI-360204 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005221 ! H31_HUMAN [Term] id: CCO:I0007727 name: app-apbb1-5 physical interaction comment: in vitro co-ip of beta-APP cytoplasmic domain and fe65 xref: IntAct:EBI-371450 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007728 name: lats1-zyx-4 physical interaction comment: Interaction betwen human LATS1 and ZYX confirmed by co-immunoprecipitation xref: IntAct:EBI-444259 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0007729 name: lats1-cdc2-2 physical interaction comment: Interaction between human LATS1 and CDC2 demonstrated by Y2H xref: IntAct:EBI-444369 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0001493 ! CDC2_HUMAN [Term] id: CCO:I0007730 name: lats1-limk1-4 physical interaction comment: Interaction of human LATS1 and LIMK1, domains identified using GST-pull down xref: IntAct:EBI-444472 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005606 ! LIMK1_HUMAN [Term] id: CCO:I0007731 name: skp2-cks1-1 physical interaction comment: Interaction between SKP2 and CKS1 demonstrated in vitro xref: IntAct:EBI-456369 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001686 ! CKS1_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN [Term] id: CCO:I0007732 name: skp2-cks1-2 physical interaction comment: Interaction between SKP2 and CKS1 demonstrated in vitro xref: IntAct:EBI-456385 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001686 ! CKS1_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN [Term] id: CCO:I0007733 name: skp2-cks1-4 physical interaction comment: Formation of SCF-SKP2 demonstrated in vitro xref: IntAct:EBI-456401 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001686 ! CKS1_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0005491 ! RBX1_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0007734 name: taf1l-tbp-1 physical interaction comment: TAF1l interacts with human TBP, as detected by Y2H. xref: IntAct:EBI-475867 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001959 ! TAF1L_HUMAN relationship: has_participant CCO:B0005481 ! TBP_HUMAN [Term] id: CCO:I0007737 name: hd-p53-3 physical interaction comment: in vivo GST-pull down : bait = huntingtin poly(Q) region ; prey = P53 xref: IntAct:EBI-493052 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005407 ! HD_HUMAN [Term] id: CCO:I0007738 name: hd-p53-4 physical interaction comment: in vivo GST-pull down : bait = huntingtin poly(Q) region ; prey = P53 xref: IntAct:EBI-493068 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005407 ! HD_HUMAN [Term] id: CCO:I0007739 name: cdk4-ccnd1-4 physical interaction comment: in vitro co-IP: bait = cyclin D1, prey = cdk4 xref: IntAct:EBI-519455 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN [Term] id: CCO:I0007741 name: cdn1b-kpna5-4 physical interaction comment: pull-down: bait = p27 KIP1 peptide, prey= importin alpha 5 xref: IntAct:EBI-540655 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005697 ! IMA5_HUMAN [Term] id: CCO:I0007742 name: cdn1b-ywhab-1 physical interaction comment: pull-down: bait = phosphorylated thr127 p27 KIP1 peptide, prey= 14-3-3 beta xref: IntAct:EBI-540682 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005480 ! 1433B_HUMAN [Term] id: CCO:I0007743 name: cdn1b-ywhae-1 physical interaction comment: pull-down: bait = phosphorylated thr127 p27 KIP1 peptide, prey = 14-3-3 epsilon xref: IntAct:EBI-540704 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005488 ! 1433E_HUMAN [Term] id: CCO:I0007744 name: cdn1b-ywhag-1 physical interaction comment: pull-down: bait = phosphorylated thr127 p27 KIP1 peptide, prey = 14-3-3 gamma xref: IntAct:EBI-540723 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0005489 ! 1433G_HUMAN [Term] id: CCO:I0007747 name: gnai1-gpsm2-2 physical interaction xref: IntAct:EBI-618721 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0005493 ! GNAI1_HUMAN [Term] id: CCO:I0007748 name: c9orf76-blm-1 physical interaction comment: coimmunoprecipitation: bait = BLAP75, preys = BLM, TOPOIIIalpha, RPA70, RPA32 xref: IntAct:EBI-621416 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001753 ! TOP3A_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0005919 ! RMI1_HUMAN [Term] id: CCO:I0007749 name: blm-c9orf76-1 physical interaction comment: coimmunoprecipitation: bait = BLM, preys = BLAP75, TOPOIIIalpha, RPA70, RPA32, RPA14 xref: IntAct:EBI-621422 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001562 ! RFA1_HUMAN relationship: has_participant CCO:B0001753 ! TOP3A_HUMAN relationship: has_participant CCO:B0005500 ! RFA2_HUMAN relationship: has_participant CCO:B0005501 ! RFA3_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0005919 ! RMI1_HUMAN [Term] id: CCO:I0007750 name: gpsm2-numa1-4 physical interaction xref: IntAct:EBI-624047 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0005492 ! GPSM2_HUMAN [Term] id: CCO:I0007751 name: abl1-sorbs-1 physical interaction comment: Interaction between SORB1 and ABL1 demonstrated by coimmunoprecipitation xref: IntAct:EBI-624110 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0005641 ! SRBS1_HUMAN [Term] id: CCO:I0007752 name: hcfc1-creb3-1 physical interaction comment: Cell-based recruitment assay to determine interaction between hcfc1 and creb3 and effects of mutations within hcfc1 upon this interaction. xref: IntAct:EBI-624998 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005498 ! CREB3_HUMAN [Term] id: CCO:I0007753 name: mdm2-npm1-1 physical interaction comment: coIP: bait = HDM2, prey = NPM xref: IntAct:EBI-626277 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0007754 name: hcfc1-zf-4 physical interaction comment: GST pull-down of interaction between hcfc1 and zf and the effect of p134s mutation in hcfc1 xref: IntAct:EBI-633114 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005710 ! ZHANG_HUMAN [Term] id: CCO:I0007755 name: hcfc1-zf-5 physical interaction comment: Mammalian two-hybrid assay of interaction between hcfc1 and zf xref: IntAct:EBI-633135 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005498 ! CREB3_HUMAN relationship: has_participant CCO:B0005710 ! ZHANG_HUMAN [Term] id: CCO:I0007756 name: brg1-baf250a-2 physical interaction comment: coIP: bait = brg1, preys = baf250a, baf170, baf155, baf60a, baf53, snf5, actin xref: IntAct:EBI-638024 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:I0007757 name: pten-mast3-1 physical interaction comment: Interaction between human PTEN and Mast3 identified by GST pulldown xref: IntAct:EBI-696276 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0005499 ! MAST3_HUMAN [Term] id: CCO:I0007758 name: actn2-ttn-2 physical interaction comment: Detection of alpha-actinin 2 and Titin binding domains by yeast two hybrid. xref: IntAct:EBI-698577 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0005642 ! ACTN2_HUMAN [Term] id: CCO:I0007762 name: blm-rpa1-1 physical interaction comment: ELISA: bait =BLM, probe = human Replication Protein A RPA70 (70kDa subunit) xref: IntAct:EBI-707256 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001562 ! RFA1_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0007763 name: blm-rpa1-2 physical interaction comment: ELISA: bait=BLM, probe = human Replication Protein A RPA70 (70kDa subunit) xref: IntAct:EBI-707269 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001562 ! RFA1_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0007764 name: bak-bax-1 physical interaction comment: Interaction of BAK and BAX identified by coimmunoprecipitation xref: IntAct:EBI-707374 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001723 ! BAX_HUMAN relationship: has_participant CCO:B0005420 ! BAK_HUMAN [Term] id: CCO:I0007768 name: blm-terf2-6 direct interaction comment: In vitro Co-IP: bait= TRF2 (TERF2), prey = BLM xref: IntAct:EBI-711071 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0007769 name: bcl6-hdac5 physical interaction comment: Coimuunoprecipitation of the BCL6 immunocomplex. xref: IntAct:EBI-765648 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001352 ! E2F3_HUMAN relationship: has_participant CCO:B0001603 ! BCL6_HUMAN relationship: has_participant CCO:B0001679 ! HDAC4_HUMAN relationship: has_participant CCO:B0002160 ! GRLF1_HUMAN relationship: has_participant CCO:B0002222 ! HDAC9_HUMAN relationship: has_participant CCO:B0002244 ! HDAC5_HUMAN relationship: has_participant CCO:B0005357 ! SIN3A_HUMAN relationship: has_participant CCO:B0005477 ! TRIB3_HUMAN relationship: has_participant CCO:B0005553 ! NCOR2_HUMAN relationship: has_participant CCO:B0005793 ! MED23_HUMAN relationship: has_participant CCO:B0005849 ! KI13B_HUMAN relationship: has_participant CCO:B0005934 ! WNK4_HUMAN relationship: has_participant CCO:B0005935 ! PKCB1_HUMAN relationship: has_participant CCO:B0006004 ! CSMD1_HUMAN relationship: has_participant CCO:B0006005 ! LSM1_HUMAN relationship: has_participant CCO:B0006006 ! EHMT1_HUMAN relationship: has_participant CCO:B0006007 ! ARI1A_HUMAN relationship: has_participant CCO:B0006008 ! HNF1A_HUMAN relationship: has_participant CCO:B0006009 ! OSBL1_HUMAN relationship: has_participant CCO:B0006010 ! TNR8_HUMAN relationship: has_participant CCO:B0006011 ! TYY1_HUMAN relationship: has_participant CCO:B0006012 ! 4ET_HUMAN relationship: has_participant CCO:B0006013 ! DDX6_HUMAN relationship: has_participant CCO:B0006014 ! ZN443_HUMAN relationship: has_participant CCO:B0006015 ! E2AK3_HUMAN relationship: has_participant CCO:B0006016 ! ATF7_HUMAN relationship: has_participant CCO:B0006017 ! SPTC2_HUMAN relationship: has_participant CCO:B0006018 ! SENP7_HUMAN relationship: has_participant CCO:B0006019 ! LPP3_HUMAN relationship: has_participant CCO:B0006020 ! BC11A_HUMAN relationship: has_participant CCO:B0006021 ! IDI2_HUMAN relationship: has_participant CCO:B0006022 ! PCDH9_HUMAN relationship: has_participant CCO:B0006023 ! T3JAM_HUMAN relationship: has_participant CCO:B0006024 ! EPHB6_HUMAN relationship: has_participant CCO:B0006025 ! WDR35_HUMAN relationship: has_participant CCO:B0006026 ! RNC_HUMAN relationship: has_participant CCO:B0006027 ! ELF1_HUMAN relationship: has_participant CCO:B0006028 ! DYH9_HUMAN relationship: has_participant CCO:B0006029 ! PANX3_HUMAN relationship: has_participant CCO:B0006030 ! COE1_HUMAN relationship: has_participant CCO:B0006031 ! PRGC1_HUMAN relationship: has_participant CCO:B0006032 ! WBP7_HUMAN relationship: has_participant CCO:B0006033 ! ARNT2_HUMAN relationship: has_participant CCO:B0006034 ! JIP3_HUMAN relationship: has_participant CCO:B0006035 ! PR285_HUMAN relationship: has_participant CCO:B0006036 ! ERCC5_HUMAN relationship: has_participant CCO:B0006037 ! PAR12_HUMAN relationship: has_participant CCO:B0006038 ! NKRF_HUMAN relationship: has_participant CCO:B0006039 ! SMO_HUMAN relationship: has_participant CCO:B0006040 ! OLA1_HUMAN relationship: has_participant CCO:B0006041 ! TBL1R_HUMAN relationship: has_participant CCO:B0006042 ! MINT_HUMAN relationship: has_participant CCO:B0006043 ! EDG4_HUMAN relationship: has_participant CCO:B0006044 ! CAC1A_HUMAN relationship: has_participant CCO:B0006045 ! P2RY9_HUMAN relationship: has_participant CCO:B0006046 ! SAE1_HUMAN relationship: has_participant CCO:B0006047 ! WNT16_HUMAN relationship: has_participant CCO:B0006048 ! HSF4_HUMAN relationship: has_participant CCO:B0006049 ! PO2F3_HUMAN relationship: has_participant CCO:B0006050 ! UTP6_HUMAN relationship: has_participant CCO:B0006051 ! JHD1A_HUMAN relationship: has_participant CCO:B0006052 ! MTMR6_HUMAN [Term] id: CCO:I0007770 name: ruvbl1-ruvbl2 physical interaction comment: MudPit analysis isolates proteins associated with Ruvbl1. xref: IntAct:EBI-769253 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005360 ! MRGBP_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN relationship: has_participant CCO:B0005362 ! ZNHI1_HUMAN relationship: has_participant CCO:B0005363 ! EAF1_HUMAN relationship: has_participant CCO:B0005364 ! RUVB2_HUMAN relationship: has_participant CCO:B0005365 ! DMAP1_HUMAN relationship: has_participant CCO:B0005366 ! ACL6A_HUMAN relationship: has_participant CCO:B0005367 ! ARP6_HUMAN relationship: has_participant CCO:B0005369 ! EPC1_HUMAN relationship: has_participant CCO:B0006053 ! CCD95_HUMAN relationship: has_participant CCO:B0006055 ! ZNHI4_HUMAN relationship: has_participant CCO:B0006056 ! INOC1_HUMAN relationship: has_participant CCO:B0006057 ! TFE2_HUMAN [Term] id: CCO:I0007771 name: ruvbl2-ruvbl1 physical interaction comment: MudPit analysis isolates proteins associated with Ruvbl2. xref: IntAct:EBI-769446 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005364 ! RUVB2_HUMAN [Term] id: CCO:I0007772 name: mrgbp-ruvbl1 physical interaction comment: MudPit analysis isolates proteins associated with MRGBP xref: IntAct:EBI-769473 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005360 ! MRGBP_HUMAN [Term] id: CCO:I0007773 name: znf-ruvbl physical interaction comment: MudPit analysis isolates proteins associated with ZNF xref: IntAct:EBI-769555 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005362 ! ZNHI1_HUMAN [Term] id: CCO:I0007774 name: znhit4-ruvbl-1 physical interaction comment: MudPit analysis isolates proteins associated with ZNHIT4 xref: IntAct:EBI-769582 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0006055 ! ZNHI4_HUMAN [Term] id: CCO:I0007775 name: actr8-ruvbl physical interaction comment: MudPit analysis isolates proteins associated with ACTR8 xref: IntAct:EBI-769657 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0006058 ! ARP8_HUMAN [Term] id: CCO:I0007777 name: mcrs1-ruvbl physical interaction comment: MudPit analysis isolates proteins associated with MCRS1 xref: IntAct:EBI-769695 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002036 ! MCRS1_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN [Term] id: CCO:I0007778 name: fj90652-ruvbl-1 physical interaction comment: MudPit analysis isolates proteins associated with FJ90652 xref: IntAct:EBI-769712 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0006053 ! CCD95_HUMAN [Term] id: CCO:I0007779 name: flj20309-ruvbl-2 physical interaction comment: MudPit analysis isolates proteins associated with FLJ20309 xref: IntAct:EBI-769729 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0035953 ! YB008_HUMAN [Term] id: CCO:I0007780 name: mrgbp-ruvbl1-2 physical interaction comment: Affinity chromotography analysis isolates proteins associated with MRGBP xref: IntAct:EBI-769870 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005360 ! MRGBP_HUMAN [Term] id: CCO:I0007781 name: tcfl1-ruvbl1-3 physical interaction comment: Affinity chromotography analysis isolates proteins associated with TCFL1 xref: IntAct:EBI-769893 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005361 ! VPS72_HUMAN [Term] id: CCO:I0007782 name: znf-ruvbl1 physical interaction comment: Affinity chromotography analysis isolates proteins associated with ZNF xref: IntAct:EBI-769907 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005362 ! ZNHI1_HUMAN [Term] id: CCO:I0007784 name: tgfb1-tgfb2-bapp-2 physical interaction comment: Interaction between transforming growth factors beta 1 and beta 2 and beta amyloid precursor protein xref: IntAct:EBI-779662 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001471 ! TGFB1_HUMAN relationship: has_participant CCO:B0001687 ! TGFB2_HUMAN relationship: has_participant CCO:B0005474 ! A4_HUMAN [Term] id: CCO:I0007785 name: hrmt1l2-ilf3-3 physical interaction comment: Interaction detected by GST pull down. xref: IntAct:EBI-78797 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001734 ! ILF3_HUMAN relationship: has_participant CCO:B0005713 ! ANM1_HUMAN [Term] id: CCO:I0007786 name: top1-2 physical interaction comment: Co-immunoprecipitation analysis reveals proteins interacting with Topoisomerase 1 xref: IntAct:EBI-876685 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0005587 ! TOP1_HUMAN [Term] id: CCO:I0007787 name: ep300-nap1l1-4 physical interaction xref: IntAct:EBI-923630 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005376 ! NP1L1_HUMAN [Term] id: CCO:I0007788 name: ep300-nap1l1-5 physical interaction xref: IntAct:EBI-923635 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005376 ! NP1L1_HUMAN [Term] id: CCO:I0007790 name: cdc73-ctnnb1-3 physical interaction xref: IntAct:EBI-932426 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:I0007791 name: cdc73-ctnnb1-6 physical interaction xref: IntAct:EBI-932465 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN relationship: has_participant CCO:B0006061 ! BCL9_HUMAN [Term] id: CCO:I0007792 name: cdc73-ctnnb1-7 physical interaction xref: IntAct:EBI-932479 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN relationship: has_participant CCO:B0006062 ! PYGO2_HUMAN [Term] id: CCO:I0007793 name: tfap2c-cited2-1 physical interaction comment: Interaction between human TFAP2C and CITED2 detected by Y2H xref: IntAct:EBI-937799 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002091 ! CITE2_HUMAN relationship: has_participant CCO:B0005377 ! AP2C_HUMAN [Term] id: CCO:I0007794 name: sept5-sept11-2 direct interaction comment: Affinity chromatography analysis reveals interaction between SEPT5 protein and SEPT11 protein xref: IntAct:EBI-958153 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN relationship: has_participant CCO:B0002169 ! SEP11_HUMAN [Term] id: CCO:I0007795 name: bcl10-akt1-1 physical interaction comment: Interaction between BCL10 and Ak1 demonstrated by coimmunoprecipitation xref: IntAct:EBI-958921 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001458 ! BCL10_HUMAN relationship: has_participant CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:I0007796 name: bcl10-akt1-2 physical interaction comment: Interaction between BCL10 and Ak1 demonstrated by coimmunoprecipitation xref: IntAct:EBI-958936 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001458 ! BCL10_HUMAN relationship: has_participant CCO:B0005512 ! AKT1_HUMAN [Term] id: CCO:I0007797 name: bcl10-bcl3-1 physical interaction comment: Interaction between BCL3 and BCL10 demonstrated by coimmunoprecipitation xref: IntAct:EBI-959017 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001458 ! BCL10_HUMAN relationship: has_participant CCO:B0005513 ! BCL3_HUMAN [Term] id: CCO:I0007798 name: bcl10-bcl3-2 physical interaction comment: Interaction between BCL3 and BCL10 demonstrated by coimmunoprecipitation xref: IntAct:EBI-959026 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001458 ! BCL10_HUMAN relationship: has_participant CCO:B0005513 ! BCL3_HUMAN [Term] id: CCO:I0007799 name: st5-abl1-1 physical interaction xref: IntAct:EBI-962642 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: has_participant CCO:B0006063 ! ST5_HUMAN [Term] id: CCO:I0007800 name: hspcb-chk1-1 physical interaction comment: Interaction between HSPCB and CHEK1 demonstrated by coimmunoprecipitation xref: IntAct:EBI-974545 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001359 ! CHK1_HUMAN relationship: has_participant CCO:B0005580 ! HS90B_HUMAN [Term] id: CCO:I0007801 name: acaca-brca1 physical interaction xref: IntAct:EBI-978623 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0035952 ! ACACA_HUMAN [Term] id: CCO:I0007802 name: phb-tp53-1 colocalization comment: Colocalisation of Prohibitin and p53 protein xref: IntAct:EBI-985186 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001591 ! PHB_HUMAN [Term] id: CCO:I0007808 name: ubp7-daxx-7 physical interaction xref: IntAct:EBI-992660 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:I0007809 name: ubp7-daxx-8 physical interaction xref: IntAct:EBI-992896 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001712 ! MDM2_HUMAN [Term] id: CCO:I0007810 name: ubp7-daxx-9 physical interaction xref: IntAct:EBI-992993 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:I0007811 name: mdm2-daxx-2 physical interaction xref: IntAct:EBI-993197 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0002196 ! DAXX_HUMAN [Term] id: CCO:I0007813 name: ahr-aip-2 physical interaction xref: IntAct:EBI-993258 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0005380 ! AIP_HUMAN [Term] id: CCO:I0007814 name: cdc27-nek2-1 physical interaction xref: IntAct:EBI-994928 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001572 ! CDC27_HUMAN relationship: has_participant CCO:B0001654 ! NEK2_HUMAN [Term] id: CCO:I0007816 name: spbc24-spbc25-5 colocalization comment: colocalization of hSpc24 and hSpc25 by immunofluorescence microscopy. xref: IntAct:EBI-1000369 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0007817 name: erbb2-egfr-4 physical interaction xref: IntAct:EBI-1001015 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005540 ! ERBB2_HUMAN [Term] id: CCO:I0007818 name: zwint_kntc2_1 physical interaction comment: coIP; bait=zwint, preys=c20orf172, casc5, cetn3, kntc2, mis12, pmf1 and spbc24 xref: IntAct:EBI-1001131 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001368 ! CETN3_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN relationship: has_participant CCO:B0001912 ! PMF1_HUMAN relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002122 ! MIS12_HUMAN relationship: has_participant CCO:B0002134 ! DSN1_HUMAN relationship: has_participant CCO:B0006064 ! CASC5_HUMAN [Term] id: CCO:I0007819 name: zw10_zwilch_1 physical interaction comment: coIP; bait=zw10, preys=c19orf25, kntc1, rint1 and zwilch xref: IntAct:EBI-1001216 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001645 ! KNTC1_HUMAN relationship: has_participant CCO:B0001909 ! RINT1_HUMAN relationship: has_participant CCO:B0006066 ! CS025_HUMAN [Term] id: CCO:I0007820 name: zwint_zw10_1 physical interaction comment: coIP; bait=zwint, prey=zw10 xref: IntAct:EBI-1001272 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN [Term] id: CCO:I0007821 name: mcm7-smc1-1 direct interaction comment: Interaction between human MCM7 and Smc1 detected by coIP xref: IntAct:EBI-1004682 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN [Term] id: CCO:I0007822 name: stmn1-cdkn1b physical interaction xref: IntAct:EBI-1006412 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001528 ! STMN1_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007823 name: hnrpd-ube2i physical interaction xref: IntAct:EBI-1024437 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005686 ! HNRPD_HUMAN [Term] id: CCO:I0007824 name: tp53-nfya-1 physical interaction xref: IntAct:EBI-1025803 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005382 ! NFYB_HUMAN relationship: has_participant CCO:B0005384 ! NFYA_HUMAN [Term] id: CCO:I0007825 name: ccna2-cdk2-1 physical interaction comment: P27(kip1)/cyclin a/cdk2 complex xref: IntAct:EBI-1026119 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN [Term] id: CCO:I0007828 name: cdk5-cdk5r1-1 direct interaction comment: Structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin. xref: IntAct:EBI-1041602 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001709 ! CDK5_HUMAN relationship: has_participant CCO:B0001802 ! CD5R1_HUMAN [Term] id: CCO:I0007829 name: cdk5-cdk5r1-2 direct interaction comment: Structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin. xref: IntAct:EBI-1041613 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001709 ! CDK5_HUMAN relationship: has_participant CCO:B0001802 ! CD5R1_HUMAN [Term] id: CCO:I0007830 name: cdk5-cdk5r1-3 direct interaction comment: Structural mechanism for the inhibition of cd5-p25 from the roscovitine, aloisine and indirubin. xref: IntAct:EBI-1041624 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001709 ! CDK5_HUMAN relationship: has_participant CCO:B0001802 ! CD5R1_HUMAN [Term] id: CCO:I0007835 name: tp53-fbxo11-1 physical interaction comment: Interaction between p53 and FBX011 identified by pulldown xref: IntAct:EBI-1167834 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005332 ! FBX11_HUMAN [Term] id: CCO:I0007836 name: cftr-ebp-2 physical interaction xref: IntAct:EBI-1171716 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001418 ! DNJA2_HUMAN relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0005605 ! CFTR_HUMAN [Term] id: CCO:I0007837 name: qsk-ywhaz-2 physical interaction comment: Interaction between 14-3-3Z , QSK and SNF1LK identified by pulldown xref: IntAct:EBI-1181817 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001680 ! SN1L1_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0007838 name: msh2-msh6-2 physical interaction comment: Mutations in hMSH2 affect the binding of hMSH2-hMSH6 hetrodimers to mismatches xref: IntAct:EBI-1187734 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0005639 ! MSH6_HUMAN [Term] id: CCO:I0007839 name: brca1-brap-2 physical interaction comment: Interaction between BRCA1 and BRAP confirmed by GST pull-down xref: IntAct:EBI-349963 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0005471 ! BRAP_HUMAN [Term] id: CCO:I0007840 name: kpna-bcra1 physical interaction comment: Interaction between BRCA1 and importin-alpha2 confirmed by GST pull-down xref: IntAct:EBI-350128 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001657 ! IMA2_HUMAN [Term] id: CCO:I0007841 name: bcra1-kpna2 physical interaction comment: Importin alpha-2 binds to the nuclear localisation signal of BRCA1 confirmed by GST pull down xref: IntAct:EBI-350135 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001657 ! IMA2_HUMAN [Term] id: CCO:I0007845 name: ywhaz-egfr-2 colocalization comment: 14-3-3 zeta colocalize with EGFR at the plasma membrane after EGF stimulation xref: IntAct:EBI-446474 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN [Term] id: CCO:I0007846 name: skp2-cks1-3 physical interaction comment: Interaction between SKP2 and CKS1 demonstrated in vitro xref: IntAct:EBI-456394 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001686 ! CKS1_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN [Term] id: CCO:I0007847 name: sirt2-pcaf-3 physical interaction comment: Interaction between SIRT2 and PCAF detected by in vitro binding assay. xref: IntAct:EBI-477610 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN [Term] id: CCO:I0007849 name: hd-p53-1 physical interaction comment: p53 found in purified huntingtin poly(Q) aggregates xref: IntAct:EBI-492984 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005407 ! HD_HUMAN [Term] id: CCO:I0007850 name: h2afx-mre11a-1 colocalization xref: IntAct:EBI-494901 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001526 ! H2AX_HUMAN relationship: has_participant CCO:B0001641 ! MRE11_HUMAN [Term] id: CCO:I0007851 name: h2afx-nbs1-3 physical interaction xref: IntAct:EBI-495031 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:I0007852 name: h2afx-brca1-1 physical interaction xref: IntAct:EBI-495228 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001526 ! H2AX_HUMAN relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN [Term] id: CCO:I0007853 name: cdkn1a-ccne1-6 physical interaction comment: GST pull down : bait=p21-CIP1, prey = cyclin E1, prey = cdk2 xref: IntAct:EBI-519772 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0007854 name: cdkn1a-ccnd1-2 physical interaction comment: GST pull down : bait=p21-CIP1, prey = cyclin D, prey = cdk4 xref: IntAct:EBI-519780 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0007855 name: cdkn1a-ccna1-1 physical interaction comment: GST pull down : bait=p21-CIP1, prey = cyclin A1, prey = cdk2 xref: IntAct:EBI-519817 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN [Term] id: CCO:I0007856 name: cdkn1a-ccne1-7 physical interaction comment: GST pull down : bait=p21-CIP1, prey = cyclin E1 xref: IntAct:EBI-519832 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0007857 name: cdkn1a-cdk2-2 physical interaction comment: GST pull down : bait=p21-CIP1, prey = cdk2 xref: IntAct:EBI-519842 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN [Term] id: CCO:I0007858 name: dapk-erk-1 physical interaction comment: Directed yeast-2-hybrid reveals interaction between death-associated protein kinase 1protein and the mitogen-activated protein kinase 3 protein xref: IntAct:EBI-525597 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001560 ! MK03_HUMAN relationship: has_participant CCO:B0005482 ! DAPK1_HUMAN [Term] id: CCO:I0007860 name: raf1-pbk physical interaction comment: Y2H: bait = C-Raf ,prey = TOPK/BPK-MPAKK-like protein kinase cap site form 2 xref: IntAct:EBI-537293 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002045 ! TOPK_HUMAN relationship: has_participant CCO:B0005636 ! RAF1_HUMAN [Term] id: CCO:I0007861 name: cdn1b-kpna3-3 physical interaction comment: in vitro transport assay of Flag-p27 KIP1 by importin alpha 3, importin beta, RAN and NTF2 xref: IntAct:EBI-591758 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0005931 ! IMA3_HUMAN relationship: has_participant CCO:B0006067 ! NTF2_HUMAN [Term] id: CCO:I0007862 name: cdn1b-kpna5-5 physical interaction comment: in vitro transport assay of Flag-p27 KIP1 by importin alpha 5, importin beta, RAN and NTF2 xref: IntAct:EBI-591792 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0005697 ! IMA5_HUMAN relationship: has_participant CCO:B0005931 ! IMA3_HUMAN relationship: has_participant CCO:B0006067 ! NTF2_HUMAN [Term] id: CCO:I0007864 name: mltk-mltk-1 acetylation comment: Homodimerization of MLTK deomonstrated y coimmunoprecipitation xref: IntAct:EBI-602285 is_a: CCO:Y0000002 ! acetylation reaction relationship: has_participant CCO:B0002178 ! MLTK_HUMAN [Term] id: CCO:I0007865 name: pkn1-mapk12-1 physical interaction comment: Interaction between PKN1 and p38gamma detected by coimmunoprecipitation xref: IntAct:EBI-602432 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001665 ! MK12_HUMAN relationship: has_participant CCO:B0006068 ! PKN1_HUMAN [Term] id: CCO:I0007866 name: pkn1-mapk12-2 physical interaction comment: Interaction between PKN1 and p38gamma detected by coimmunoprecipitation xref: IntAct:EBI-602438 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001665 ! MK12_HUMAN relationship: has_participant CCO:B0006068 ! PKN1_HUMAN [Term] id: CCO:I0007867 name: pkn1-map2k6-2 physical interaction comment: Interaction between PKN1 and MKK6 detected by coimmunoprecipitation xref: IntAct:EBI-602525 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001658 ! MP2K6_HUMAN relationship: has_participant CCO:B0006068 ! PKN1_HUMAN [Term] id: CCO:I0007869 name: hdac1-rbbp4-1 physical interaction comment: Co-ip of interaction between hdac1 and rbbp4 (RbAp48). xref: IntAct:EBI-620836 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001727 ! RBBP4_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0007871 name: tacc1-chtog-7 physical interaction comment: Regions of interaction between TACC1 and chTOG identified by coimunoprecipitation xref: IntAct:EBI-624716 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001772 ! CKAP5_HUMAN [Term] id: CCO:I0007872 name: hcfc1-pou2f1-1 physical interaction comment: Co-ip (in-vitro) of interaction between hcfc1 and pou2f1 (oct-1). xref: IntAct:EBI-624757 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0006069 ! PO2F1_HUMAN [Term] id: CCO:I0007873 name: hcfc1-egr2-1 physical interaction comment: In-vivo one-hybrid recruitment assay demonstrating interaction between the beta-propeller of hcfc1 and the activation domain of egr2. xref: IntAct:EBI-625760 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0006070 ! EGR2_HUMAN [Term] id: CCO:I0007874 name: cdkn2a-huew1-1 physical interaction comment: coip: bait = p14arf, preys = arf-bp1/mule, nucleophosmin xref: IntAct:EBI-625921 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001966 ! CD2A2_HUMAN relationship: has_participant CCO:B0005709 ! HUWE1_HUMAN [Term] id: CCO:I0007875 name: hcfc1-zf-2 physical interaction comment: GST pull-down of interaction between hcfc1 and zf xref: IntAct:EBI-633035 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0005710 ! ZHANG_HUMAN [Term] id: CCO:I0007876 name: brg1-baf200-1 physical interaction comment: coIP: bait = brg1, preys = baf200, baf170, baf155, baf60a, baf53, snf5, actin xref: IntAct:EBI-638007 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0005414 ! SMCA4_HUMAN [Term] id: CCO:I0007877 name: egfr-pik3c2a-1 physical interaction comment: Interaction of PIK3C2A , PIK3C2B and EGFR demonstrated by coimmunorecipitation xref: IntAct:EBI-641139 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005711 ! P3C2B_HUMAN relationship: has_participant CCO:B0006071 ! P3C2A_HUMAN [Term] id: CCO:I0007878 name: egfr-pik3c2b-1 physical interaction comment: Interaction of PIK3C2B and EGFR demonstrated by coimmunoprecipitation xref: IntAct:EBI-641178 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0005711 ! P3C2B_HUMAN [Term] id: CCO:I0007885 name: supt5h-ppia-1 physical interaction comment: Interaction detected by His pull down. xref: IntAct:EBI-710477 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0006072 ! PPIA_HUMAN [Term] id: CCO:I0007886 name: axin1-anp32a-1 physical interaction comment: Interaction detected by GST pull down. xref: IntAct:EBI-710496 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001367 ! AXN1_HUMAN relationship: has_participant CCO:B0006073 ! AN32A_HUMAN [Term] id: CCO:I0007887 name: axin1-crmp1 physical interaction comment: Interaction detected by GST pull down. xref: IntAct:EBI-710554 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001367 ! AXN1_HUMAN relationship: has_participant CCO:B0006074 ! DPYL1_HUMAN [Term] id: CCO:I0007889 name: sufu-rcn3 physical interaction comment: Part of the co-AP dataset. xref: IntAct:EBI-760854 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005248 ! RCN3_HUMAN [Term] id: CCO:I0007890 name: pex26-sufu-1 physical interaction comment: Part of the co-AP dataset. xref: IntAct:EBI-760882 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0005312 ! PEX26_HUMAN [Term] id: CCO:I0007891 name: tak1l-gps2 physical interaction comment: Part of the co-AP dataset. xref: IntAct:EBI-760938 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001746 ! GPS2_HUMAN relationship: has_participant CCO:B0005300 ! TAK1L_HUMAN [Term] id: CCO:I0007893 name: pot1-terf2-1 physical interaction comment: Gel filtration reveals a complex consisting of POT1 , RAP1, TRF1, ACD, TERF2 and TINF2 proteins. xref: IntAct:EBI-765004 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0005503 ! POTE1_HUMAN relationship: has_participant CCO:B0005504 ! ACD_HUMAN relationship: has_participant CCO:B0005505 ! TE2IP_HUMAN [Term] id: CCO:I0007894 name: tinf2-terf1-1 physical interaction comment: Colocalisation assay reveals interaction between TINF2, TRF1 and TRF2 proteins. xref: IntAct:EBI-765157 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0001810 ! TERF2_HUMAN [Term] id: CCO:I0007895 name: cyclina1_cdk1_human direct interaction comment: Cyclin A1: CDK1 xref: IntAct:EBI-766719 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN [Term] id: CCO:I0007896 name: cyclina2_cdk1_human direct interaction comment: Cyclin A2: CDK1 xref: IntAct:EBI-766779 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN [Term] id: CCO:I0007897 name: cyclina1_cdk2_human direct interaction comment: Cyclin A1: CDK2 xref: IntAct:EBI-767663 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN [Term] id: CCO:I0007898 name: cyclina2_cdk2_human direct interaction comment: Cyclin A2: CDK2 xref: IntAct:EBI-767671 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007899 name: cyclinb1_cdk1_human direct interaction comment: Cyclin B1: CDK1 xref: IntAct:EBI-767678 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001519 ! CCNB1_HUMAN [Term] id: CCO:I0007900 name: cyclinb2_cdk1_human direct interaction comment: Cyclin B2: CDK1 xref: IntAct:EBI-767743 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001446 ! CCNB2_HUMAN relationship: has_participant CCO:B0001493 ! CDC2_HUMAN [Term] id: CCO:I0007901 name: cyclinb3_cdk2_human direct interaction comment: Cyclin B3: CDK2 xref: IntAct:EBI-767837 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0002007 ! CCNB3_HUMAN [Term] id: CCO:I0007902 name: cyclind1_cdk4_human direct interaction comment: Cyclin D1: CDK4 xref: IntAct:EBI-767849 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN [Term] id: CCO:I0007903 name: cyclind2_cdk4_human direct interaction comment: Cyclin D2: CDK4 xref: IntAct:EBI-767885 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001573 ! CCND2_HUMAN [Term] id: CCO:I0007904 name: cyclind3_cdk4_human direct interaction comment: Cyclin D3: CDK4 xref: IntAct:EBI-767922 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001574 ! CCND3_HUMAN [Term] id: CCO:I0007905 name: cyclind3_cdk6_human direct interaction comment: Cyclin D3: CDK6 xref: IntAct:EBI-768433 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:I0007906 name: cyclind1_cdk6_human direct interaction comment: Cyclin D1: CDK6 xref: IntAct:EBI-768466 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN [Term] id: CCO:I0007907 name: cycline1_cdk2_human direct interaction comment: Cyclin E1: CDK2 xref: IntAct:EBI-768477 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007908 name: cycline2_cdk2_human direct interaction comment: Cyclin E2: CDK2 xref: IntAct:EBI-768489 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001460 ! CCNE2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007909 name: pol-prim_human physical interaction comment: DNA polymerase alpha:primase complex xref: IntAct:EBI-850302 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001503 ! DPOLA_HUMAN relationship: has_participant CCO:B0005507 ! PRI1_HUMAN relationship: has_participant CCO:B0005508 ! PRI2_HUMAN relationship: has_participant CCO:B0005509 ! DPOA2_HUMAN [Term] id: CCO:I0007910 name: pold1-pold2-6 physical interaction comment: Assembly of DNA polymerase delta identifed by glycerol gradient centrifugation xref: IntAct:EBI-865073 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005882 ! DPOD4_HUMAN relationship: has_participant CCO:B0005883 ! DPOD2_HUMAN relationship: has_participant CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:I0007911 name: pold1-pold2-7 physical interaction comment: Assembly of DNA polymerase delta identifed by glycerol gradient centrifugation xref: IntAct:EBI-865095 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005882 ! DPOD4_HUMAN relationship: has_participant CCO:B0005883 ! DPOD2_HUMAN relationship: has_participant CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:I0007912 name: dpol-delta_human physical interaction comment: DNA polymerase delta heterotetramer xref: IntAct:EBI-866690 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005882 ! DPOD4_HUMAN relationship: has_participant CCO:B0005883 ! DPOD2_HUMAN relationship: has_participant CCO:B0005884 ! DPOD3_HUMAN [Term] id: CCO:I0007913 name: dpol-epsilon_human physical interaction comment: DNA polymerase epsilon heterotetramer xref: IntAct:EBI-876717 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001724 ! DPOE1_HUMAN relationship: has_participant CCO:B0005885 ! DPOE3_HUMAN relationship: has_participant CCO:B0005904 ! DPOE2_HUMAN relationship: has_participant CCO:B0005905 ! DPOE4_HUMAN [Term] id: CCO:I0007914 name: mcm2-7_human physical interaction comment: MCM2-7 heterohexomer xref: IntAct:EBI-913604 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0001588 ! MCM5_HUMAN relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0005391 ! MCM4_HUMAN [Term] id: CCO:I0007915 name: wee1-plk1 phosphorylation xref: IntAct:EBI-914853 is_a: CCO:Y0000024 ! phosphorylation reaction relationship: has_participant CCO:B0001575 ! WEE1_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN [Term] id: CCO:I0007916 name: pa2g4-hdac2-1 physical interaction xref: IntAct:EBI-924912 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN relationship: has_participant CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:I0007917 name: parafibromin-ctnnb1 physical interaction xref: IntAct:EBI-930154 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN [Term] id: CCO:I0007918 name: ap2a-ubc9-1 physical interaction comment: Interaction between human AP2 alpha and UBC9 detected by Y2H xref: IntAct:EBI-937334 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0007919 name: ap2b-ubc9-1 physical interaction comment: Interaction between human AP2 beta and UBC9 detected by Y2H xref: IntAct:EBI-937338 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005680 ! AP2B_HUMAN [Term] id: CCO:I0007920 name: ap2g-ubc9-2 physical interaction comment: Interaction between human AP2 gamma and UBC9 detected by Y2H xref: IntAct:EBI-937341 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005377 ! AP2C_HUMAN [Term] id: CCO:I0007921 name: ubc9-ap2a-1 physical interaction comment: Interaction between human UBC9 and APC alpha detected by Y2H xref: IntAct:EBI-937366 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005640 ! AP2A_HUMAN [Term] id: CCO:I0007922 name: ubc9-ap2b-1 physical interaction comment: Interaction between human UBC9 and APC beta detected by Y2H xref: IntAct:EBI-937371 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005680 ! AP2B_HUMAN [Term] id: CCO:I0007923 name: ubc9-ap2g-1 physical interaction comment: Interaction between human UBC9 and APC gamma detected by Y2H xref: IntAct:EBI-937381 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0005377 ! AP2C_HUMAN [Term] id: CCO:I0007924 name: phb-tp53 colocalization comment: Colocalisation of Prohibitin and p53 protein xref: IntAct:EBI-985118 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001591 ! PHB_HUMAN [Term] id: CCO:I0007925 name: brca2-rad51-5 physical interaction comment: Interaction between BRCA2 and RAD51 determined by GST-pulldown xref: IntAct:EBI-987097 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007926 name: brca2-rad51-6 direct interaction comment: Interaction between BRCA2 and RAD51 determined by GST-pulldown xref: IntAct:EBI-987144 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007927 name: brca2-rad51-7 physical interaction comment: Interaction between BRCA2 and RAD51 determined by GST-pulldown xref: IntAct:EBI-987246 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007929 name: cdc27-nek2 physical interaction xref: IntAct:EBI-994872 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001572 ! CDC27_HUMAN relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001739 ! CDC16_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0002216 ! ANC2_HUMAN [Term] id: CCO:I0007931 name: usp7-tp53-4 physical interaction xref: IntAct:EBI-997438 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005429 ! UBP7_HUMAN [Term] id: CCO:I0007932 name: kntc2-spbc24-2 physical interaction xref: IntAct:EBI-1000048 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN [Term] id: CCO:I0007941 name: ccna2-cdk2-9 direct interaction comment: Structure of cdk2-cyclin a with pnu-292137 xref: IntAct:EBI-1039274 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN [Term] id: CCO:I0007942 name: apc-ctnnb1-1 physical interaction comment: Crystal structure of beta-catenin-icat helical domain-unphosphorylated apc r3 xref: IntAct:EBI-1039979 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN relationship: has_participant CCO:B0006076 ! CNBP1_HUMAN [Term] id: CCO:I0007943 name: fbxo11-skp1-1 physical interaction comment: Interaction between FBXO11, SKP1, CUL1 and RBX1(ROC1) identified by coimmunoprecipitation xref: IntAct:EBI-1168068 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0005332 ! FBX11_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0007944 name: rad51-rad51-6 physical interaction xref: IntAct:EBI-1178794 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007945 name: atm-aatf physical interaction comment: Che-1 coimmunoprecipitates with ATM xref: IntAct:EBI-1180741 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001750 ! ATM_HUMAN relationship: has_participant CCO:B0005446 ! AATF_HUMAN [Term] id: CCO:I0007946 name: cdc2l1-pak1-2 physical interaction comment: CDC2L1-PAK1 detection by immunoprecipitation xref: IntAct:EBI-1333 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001540 ! CD2L1_HUMAN relationship: has_participant CCO:B0005469 ! PAK1_HUMAN [Term] id: CCO:I0007947 name: brca2-rad51-3 physical interaction comment: Regions of BRCA2 neccessary for interaction determined by Y2H. xref: IntAct:EBI-298257 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN [Term] id: CCO:I0007948 name: egfr-shc1-1 physical interaction comment: Interaction of the complex detected by CoIP. xref: IntAct:EBI-350217 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001357 ! ANM5_HUMAN relationship: has_participant CCO:B0001418 ! DNJA2_HUMAN relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0001494 ! S10A6_HUMAN relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0001501 ! K2C7_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0001689 ! PP1B_HUMAN relationship: has_participant CCO:B0001734 ! ILF3_HUMAN relationship: has_participant CCO:B0002060 ! NEB2_HUMAN relationship: has_participant CCO:B0002186 ! RCC2_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0007949 name: tp53-hmgb1 physical interaction comment: p53 binds directly to HMG-1 in vitro xref: IntAct:EBI-389443 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005929 ! HMGB1_HUMAN [Term] id: CCO:I0007950 name: lats1-zyx-2 physical interaction comment: Interaction betwen human LATS1 and ZYX confirmed by co-immunoprecipitation xref: IntAct:EBI-444251 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0007951 name: lats1-zyx-3 physical interaction comment: Interaction betwen human LATS1 and ZYX confirmed by co-immunoprecipitation xref: IntAct:EBI-444278 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0007952 name: lats1-zyx-5 physical interaction comment: Interaction betwen human LATS1 and ZYX, domains defined by GST pull down xref: IntAct:EBI-444288 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0007953 name: lats1-zyx-7 physical interaction comment: Interaction betwen human LATS1 and ZYX, phosporylation requirement defined by GST pull down xref: IntAct:EBI-444303 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0007954 name: hif1a-ep300-1 physical interaction comment: Interaction of HIF1A with EP300 confirmed by GST-pull down. xref: IntAct:EBI-447320 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0005430 ! HIF1A_HUMAN [Term] id: CCO:I0007956 name: epas1-ep300-1 physical interaction comment: Interaction of EPAS1 with EP300 confirmed by GST-pull down. xref: IntAct:EBI-447503 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0006077 ! EPAS1_HUMAN [Term] id: CCO:I0007957 name: cdt1-gmnn-4 physical interaction comment: Interaction between Geminin and CDT1 identified by GST-pull-down xref: IntAct:EBI-456975 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001432 ! GEMI_HUMAN relationship: has_participant CCO:B0002126 ! CDT1_HUMAN [Term] id: CCO:I0007958 name: lats1-zyx-8 physical interaction comment: Interaction betwen human LATS1 and ZYX, domains defined by GST pull down xref: IntAct:EBI-464050 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0007959 name: lats1-zyx-9 physical interaction comment: Interaction betwen human LATS1 and ZYX, domains defined by GST pull down xref: IntAct:EBI-491492 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0007960 name: lats1-zyx-10 physical interaction comment: Interaction betwen human LATS1 and ZYX, domains defined by GST pull down xref: IntAct:EBI-491502 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0005704 ! ZYX_HUMAN [Term] id: CCO:I0007961 name: pb1-arid2-1 physical interaction comment: coIP: bait = baf180; prey = baf200 xref: IntAct:EBI-637806 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001938 ! PB1_HUMAN relationship: has_participant CCO:B0005497 ! ARID2_HUMAN [Term] id: CCO:I0007963 name: egfr-yes-2 physical interaction comment: Proteomics studies using anti-EGFR affinity chromatography xref: IntAct:EBI-702413 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001437 ! BCAR3_HUMAN relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0001584 ! 1433S_HUMAN relationship: has_participant CCO:B0005409 ! IMB1_HUMAN relationship: has_participant CCO:B0005413 ! 1433Z_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN relationship: has_participant CCO:B0005456 ! CAV1_HUMAN relationship: has_participant CCO:B0005465 ! YES_HUMAN relationship: has_participant CCO:B0005488 ! 1433E_HUMAN relationship: has_participant CCO:B0005540 ! ERBB2_HUMAN relationship: has_participant CCO:B0005812 ! FAK1_HUMAN relationship: has_participant CCO:B0005824 ! CTNA1_HUMAN relationship: has_participant CCO:B0005826 ! PKP2_HUMAN relationship: has_participant CCO:B0005831 ! EF1A1_HUMAN relationship: has_participant CCO:B0005832 ! EPHA2_HUMAN relationship: has_participant CCO:B0005836 ! ACK1_HUMAN relationship: has_participant CCO:B0005837 ! PAXI_HUMAN relationship: has_participant CCO:B0005839 ! CTND1_HUMAN relationship: has_participant CCO:B0005841 ! BCAR1_HUMAN relationship: has_participant CCO:B0005846 ! FAK2_HUMAN [Term] id: CCO:I0007964 name: hck-sam68-1 physical interaction comment: In vitro pull-down: bait= hck SH3 domain, prey = sam68 xref: IntAct:EBI-780858 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005894 ! HCK_HUMAN [Term] id: CCO:I0007965 name: lck-sam68-1 physical interaction comment: In vitro pull-down: bait= Lck SH3 domain, prey = sam68 xref: IntAct:EBI-780873 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001490 ! LCK_HUMAN relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN [Term] id: CCO:I0007966 name: grb2-sam68-1 physical interaction comment: In vitro pull-down: bait= Grb2 SH3 domain 1, prey = sam68 xref: IntAct:EBI-780898 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN [Term] id: CCO:I0007967 name: grb2-sam68-2 physical interaction comment: In vitro pull-down: bait= Grb2 SH3 domain 2, prey = sam68 xref: IntAct:EBI-780909 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005454 ! GRB2_HUMAN [Term] id: CCO:I0007968 name: pold1pold2-8 physical interaction comment: Interaction of POLD4 with POLD1 identified by coimmunoprecipitation xref: IntAct:EBI-865108 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005882 ! DPOD4_HUMAN [Term] id: CCO:I0007969 name: myc-nmi-1 physical interaction comment: Interaction between human Myc and Nmi detected by beta galactosidase assay xref: IntAct:EBI-878432 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0005695 ! NMI_HUMAN [Term] id: CCO:I0007970 name: disc1-tubg-1 physical interaction comment: Co-sedimentation of DISC1 protein, gamma tubulin protein and Pericentrin protein xref: IntAct:EBI-930616 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001548 ! TBG1_HUMAN relationship: has_participant CCO:B0005591 ! DISC1_HUMAN relationship: has_participant CCO:B0006078 ! PCNT_HUMAN [Term] id: CCO:I0007972 name: mbde-suv93h1-2 physical interaction xref: IntAct:EBI-994609 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005510 ! MBD1_HUMAN [Term] id: CCO:I0007973 name: suv93h1-mbde-2 physical interaction xref: IntAct:EBI-994624 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005510 ! MBD1_HUMAN [Term] id: CCO:I0007974 name: suv93h1-cbx-1 physical interaction xref: IntAct:EBI-994679 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005317 ! CBX5_HUMAN [Term] id: CCO:I0007975 name: suv93h1-hdac1-1 physical interaction xref: IntAct:EBI-994733 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0007976 name: suv93h1-hdac1-2 physical interaction xref: IntAct:EBI-994740 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0007977 name: suv93h1-hdac2-1 physical interaction xref: IntAct:EBI-994747 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:I0007978 name: suv93h1-hdac2-2 physical interaction xref: IntAct:EBI-994754 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0005343 ! HDAC2_HUMAN [Term] id: CCO:I0007981 name: cdk4-cdkn2b physical interaction xref: IntAct:EBI-728471 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001616 ! CDN2B_HUMAN [Term] id: CCO:I0007982 name: cdkn2c-tp53 physical interaction xref: IntAct:EBI-728477 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN [Term] id: CCO:I0007983 name: cdkn2c-unc119 physical interaction xref: IntAct:EBI-728480 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0006080 ! UN119_HUMAN [Term] id: CCO:I0007984 name: cpe-rif1 physical interaction xref: IntAct:EBI-728492 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006081 ! CBPE_HUMAN [Term] id: CCO:I0007985 name: dleu1-eef1a1 physical interaction xref: IntAct:EBI-728504 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:I0007986 name: dleu1-eef1g physical interaction xref: IntAct:EBI-728507 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0006079 ! EF1G_HUMAN [Term] id: CCO:I0007987 name: erh-tp53 physical interaction xref: IntAct:EBI-728513 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001703 ! ERH_HUMAN [Term] id: CCO:I0007988 name: psmd2-ptn physical interaction xref: IntAct:EBI-728570 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001541 ! PTN_HUMAN relationship: has_participant CCO:B0001745 ! PSMD2_HUMAN [Term] id: CCO:I0007990 name: rpa2-rif1 physical interaction xref: IntAct:EBI-728609 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005500 ! RFA2_HUMAN [Term] id: CCO:I0007991 name: selenbp1-rif1 physical interaction xref: IntAct:EBI-728645 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006083 ! SBP1_HUMAN [Term] id: CCO:I0007993 name: znf24-tp53 physical interaction xref: IntAct:EBI-728684 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006085 ! ZNF24_HUMAN [Term] id: CCO:I0007995 name: arih2-tp53 physical interaction xref: IntAct:EBI-728735 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005288 ! ARI2_HUMAN [Term] id: CCO:I0007997 name: axin1-crmp1-1 physical interaction xref: IntAct:EBI-728754 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001367 ! AXN1_HUMAN relationship: has_participant CCO:B0006074 ! DPYL1_HUMAN [Term] id: CCO:I0007998 name: axin1-eef1a1 physical interaction xref: IntAct:EBI-728757 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001367 ! AXN1_HUMAN relationship: has_participant CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:I0007999 name: btbd2-tp53 physical interaction xref: IntAct:EBI-728781 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005933 ! BTBD2_HUMAN [Term] id: CCO:I0008000 name: ccl18-tp53 physical interaction xref: IntAct:EBI-728811 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006087 ! CCL18_HUMAN [Term] id: CCO:I0008002 name: cdc42-rif1 physical interaction xref: IntAct:EBI-728820 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0008003 name: cdc42-tp53 physical interaction xref: IntAct:EBI-728823 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005338 ! CDC42_HUMAN [Term] id: CCO:I0008004 name: cdk4-capns1 physical interaction xref: IntAct:EBI-728826 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0006088 ! CPNS1_HUMAN [Term] id: CCO:I0008005 name: cdkn2c-rif1 physical interaction xref: IntAct:EBI-728835 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008006 name: cks2-eef1a1 physical interaction xref: IntAct:EBI-728838 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001586 ! CKS2_HUMAN relationship: has_participant CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:I0008007 name: cks2-unc119 physical interaction xref: IntAct:EBI-728841 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001586 ! CKS2_HUMAN relationship: has_participant CCO:B0006080 ! UN119_HUMAN [Term] id: CCO:I0008008 name: cox17-rif1 physical interaction xref: IntAct:EBI-728844 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006089 ! COX17_HUMAN [Term] id: CCO:I0008010 name: eif2s2-tp53 physical interaction xref: IntAct:EBI-728919 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006090 ! IF2B_HUMAN [Term] id: CCO:I0008014 name: hrmt1l2-rif1 physical interaction xref: IntAct:EBI-728973 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005713 ! ANM1_HUMAN [Term] id: CCO:I0008015 name: hspe1-rif1 physical interaction xref: IntAct:EBI-728979 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006092 ! CH10_HUMAN [Term] id: CCO:I0008016 name: kif15-kiaa1377 physical interaction xref: IntAct:EBI-729003 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002165 ! KIF15_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008017 name: lama4-rif1 physical interaction xref: IntAct:EBI-729015 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006093 ! LAMA4_HUMAN [Term] id: CCO:I0008018 name: lama4-tp53 physical interaction xref: IntAct:EBI-729018 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006093 ! LAMA4_HUMAN [Term] id: CCO:I0008021 name: mad2l1bp-tp53 physical interaction xref: IntAct:EBI-729048 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN [Term] id: CCO:I0008022 name: mphosph6-tle1 physical interaction xref: IntAct:EBI-729063 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:I0008023 name: mphosph6-tp53 physical interaction xref: IntAct:EBI-729066 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0002071 ! MPH6_HUMAN [Term] id: CCO:I0008024 name: mrps12-rif1 physical interaction xref: IntAct:EBI-729069 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006095 ! RT12_HUMAN [Term] id: CCO:I0008025 name: naca-rif1 physical interaction xref: IntAct:EBI-729072 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006096 ! NACA_HUMAN [Term] id: CCO:I0008026 name: nhp2l1-cdkn2c physical interaction xref: IntAct:EBI-729075 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0001676 ! NH2L1_HUMAN [Term] id: CCO:I0008027 name: np-rif1 physical interaction xref: IntAct:EBI-729081 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006097 ! PNPH_HUMAN [Term] id: CCO:I0008028 name: pafah1b3-rif1 physical interaction xref: IntAct:EBI-729099 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006098 ! PA1B3_HUMAN [Term] id: CCO:I0008029 name: pafah1b3-tp53 physical interaction xref: IntAct:EBI-729105 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006098 ! PA1B3_HUMAN [Term] id: CCO:I0008030 name: pcdha4-tp53 physical interaction xref: IntAct:EBI-729123 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006099 ! PCDA4_HUMAN [Term] id: CCO:I0008031 name: polr2c-rif1 physical interaction xref: IntAct:EBI-729132 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006100 ! RPB3_HUMAN [Term] id: CCO:I0008032 name: polr3f-rif1 physical interaction xref: IntAct:EBI-729138 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006101 ! RPC6_HUMAN [Term] id: CCO:I0008033 name: pp-tp53 physical interaction xref: IntAct:EBI-729141 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006102 ! IPYR_HUMAN [Term] id: CCO:I0008036 name: psmd11-rif1 physical interaction xref: IntAct:EBI-729165 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006103 ! PSD11_HUMAN [Term] id: CCO:I0008037 name: psmd11-tp53 physical interaction xref: IntAct:EBI-729171 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006103 ! PSD11_HUMAN [Term] id: CCO:I0008038 name: psmd2-rif1 physical interaction xref: IntAct:EBI-729183 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001745 ! PSMD2_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008039 name: psmd2-unc119 physical interaction xref: IntAct:EBI-729186 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001745 ! PSMD2_HUMAN relationship: has_participant CCO:B0006080 ! UN119_HUMAN [Term] id: CCO:I0008041 name: rad51-chd3 physical interaction xref: IntAct:EBI-729210 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001721 ! RAD51_HUMAN relationship: has_participant CCO:B0006082 ! CHD3_HUMAN [Term] id: CCO:I0008042 name: rfc5-rif1 physical interaction xref: IntAct:EBI-729213 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006105 ! RFC5_HUMAN [Term] id: CCO:I0008043 name: rgs2-git1 physical interaction xref: IntAct:EBI-729219 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:I0008046 name: rplp1-rif1 physical interaction xref: IntAct:EBI-729234 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005770 ! RLA1_HUMAN [Term] id: CCO:I0008047 name: sat-rif1 physical interaction xref: IntAct:EBI-729261 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006107 ! SAT1_HUMAN [Term] id: CCO:I0008048 name: sat-tp53 physical interaction xref: IntAct:EBI-729264 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006107 ! SAT1_HUMAN [Term] id: CCO:I0008050 name: serpinb9-rif1 physical interaction xref: IntAct:EBI-729282 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006108 ! SPB9_HUMAN [Term] id: CCO:I0008051 name: serpinb9-tp53 physical interaction xref: IntAct:EBI-729288 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006108 ! SPB9_HUMAN [Term] id: CCO:I0008052 name: sma3-tp53 physical interaction xref: IntAct:EBI-729321 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0041277 ! GUSP1_HUMAN [Term] id: CCO:I0008053 name: smn1-rif1 physical interaction xref: IntAct:EBI-729327 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006110 ! SMN_HUMAN [Term] id: CCO:I0008054 name: snrpn-tp53 physical interaction xref: IntAct:EBI-729339 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006111 ! RSMN_HUMAN [Term] id: CCO:I0008055 name: sult1e1-tp53 physical interaction xref: IntAct:EBI-729348 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006112 ! ST1E1_HUMAN [Term] id: CCO:I0008056 name: supt5h-med31 physical interaction xref: IntAct:EBI-729354 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0005784 ! MED31_HUMAN [Term] id: CCO:I0008058 name: tk1-rif1 physical interaction xref: IntAct:EBI-729378 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006114 ! KITH_HUMAN [Term] id: CCO:I0008059 name: tk1-tp53 physical interaction xref: IntAct:EBI-729384 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006114 ! KITH_HUMAN [Term] id: CCO:I0008060 name: tmsb4x-tp53 physical interaction xref: IntAct:EBI-729393 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006115 ! TYB4_HUMAN [Term] id: CCO:I0008062 name: znf24-rif1 physical interaction xref: IntAct:EBI-729450 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006085 ! ZNF24_HUMAN [Term] id: CCO:I0008063 name: akr1c3-rif1 physical interaction xref: IntAct:EBI-729471 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006117 ! AK1C3_HUMAN [Term] id: CCO:I0008064 name: ankrd24-rif1 physical interaction xref: IntAct:EBI-729480 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0040685 ! ANR24_HUMAN [Term] id: CCO:I0008065 name: anxa3-tp53 physical interaction xref: IntAct:EBI-729483 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006119 ! ANXA3_HUMAN [Term] id: CCO:I0008066 name: arih2-centd2 physical interaction xref: IntAct:EBI-729531 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002052 ! CEND2_HUMAN relationship: has_participant CCO:B0005288 ! ARI2_HUMAN [Term] id: CCO:I0008067 name: arl3-rif1 physical interaction xref: IntAct:EBI-729549 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006120 ! ARL3_HUMAN [Term] id: CCO:I0008068 name: arl3-tp53 physical interaction xref: IntAct:EBI-729555 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006120 ! ARL3_HUMAN [Term] id: CCO:I0008069 name: atf3-tp53 physical interaction xref: IntAct:EBI-729588 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006121 ! ATF3_HUMAN [Term] id: CCO:I0008071 name: axin1-anp32a physical interaction xref: IntAct:EBI-729609 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001367 ! AXN1_HUMAN relationship: has_participant CCO:B0006073 ! AN32A_HUMAN [Term] id: CCO:I0008072 name: bcr-tp53 physical interaction xref: IntAct:EBI-729618 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006123 ! BCR_HUMAN [Term] id: CCO:I0008073 name: bmi1-rif1 physical interaction xref: IntAct:EBI-729636 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006124 ! Q5T8Z1_HUMAN [Term] id: CCO:I0008075 name: cbx1-rif1 physical interaction xref: IntAct:EBI-729699 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006126 ! CBX1_HUMAN [Term] id: CCO:I0008076 name: cct5-tp53 physical interaction xref: IntAct:EBI-729723 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005291 ! TCPE_HUMAN [Term] id: CCO:I0008079 name: cdk4-bat3 physical interaction xref: IntAct:EBI-729744 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0006127 ! BAT3_HUMAN [Term] id: CCO:I0008080 name: cdk4-setdb1 physical interaction xref: IntAct:EBI-729747 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:I0008081 name: cdkn2b-kiaa1377 physical interaction xref: IntAct:EBI-729762 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001616 ! CDN2B_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008082 name: cdkn2c-dkfzp564o0523 physical interaction xref: IntAct:EBI-729765 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0035954 ! YG012_HUMAN [Term] id: CCO:I0008083 name: cdkn2c-drap1 physical interaction xref: IntAct:EBI-729768 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0040686 ! NC2A_HUMAN [Term] id: CCO:I0008084 name: cdkn2c-tle1 physical interaction xref: IntAct:EBI-729771 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:I0008085 name: cetn3-pde6d physical interaction xref: IntAct:EBI-729774 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001368 ! CETN3_HUMAN relationship: has_participant CCO:B0006130 ! PDE6D_HUMAN [Term] id: CCO:I0008086 name: cetn3-rif1 physical interaction xref: IntAct:EBI-729777 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001368 ! CETN3_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008087 name: cetn3-unc119 physical interaction xref: IntAct:EBI-729780 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001368 ! CETN3_HUMAN relationship: has_participant CCO:B0006080 ! UN119_HUMAN [Term] id: CCO:I0008088 name: ckmt2-rif1 physical interaction xref: IntAct:EBI-729792 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006131 ! KCRS_HUMAN [Term] id: CCO:I0008089 name: cox17-tp53 physical interaction xref: IntAct:EBI-729807 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006089 ! COX17_HUMAN [Term] id: CCO:I0008092 name: dleu1-med31 physical interaction xref: IntAct:EBI-729870 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0005784 ! MED31_HUMAN [Term] id: CCO:I0008093 name: dleu1-cops6 physical interaction xref: IntAct:EBI-729873 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0006133 ! CSN6_HUMAN [Term] id: CCO:I0008094 name: dleu1-htatip physical interaction xref: IntAct:EBI-729876 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0005351 ! TIP60_HUMAN [Term] id: CCO:I0008095 name: dleu1-kiaa1377 physical interaction xref: IntAct:EBI-729879 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008096 name: dleu1-utp14a physical interaction xref: IntAct:EBI-729882 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:I0008097 name: dleu1-tp53 physical interaction xref: IntAct:EBI-729885 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0001483 ! P53_HUMAN [Term] id: CCO:I0008098 name: dleu1-ubr1 physical interaction xref: IntAct:EBI-729891 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0006135 ! UBR1_HUMAN [Term] id: CCO:I0008100 name: dnajb9-plk1 physical interaction xref: IntAct:EBI-729900 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001663 ! PLK1_HUMAN relationship: has_participant CCO:B0006137 ! DNJB9_HUMAN [Term] id: CCO:I0008101 name: dnmt2-rif1 physical interaction xref: IntAct:EBI-729915 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006138 ! TRDMT_HUMAN [Term] id: CCO:I0008107 name: fxr1-rif1 physical interaction xref: IntAct:EBI-730042 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006140 ! FXR1_HUMAN [Term] id: CCO:I0008108 name: fxyd6-tp53 physical interaction xref: IntAct:EBI-730048 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006141 ! FXYD6_HUMAN [Term] id: CCO:I0008109 name: gnb5-mcm2 physical interaction xref: IntAct:EBI-730063 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0006142 ! GBB5_HUMAN [Term] id: CCO:I0008111 name: gps2-chd3 physical interaction xref: IntAct:EBI-730072 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001746 ! GPS2_HUMAN relationship: has_participant CCO:B0006082 ! CHD3_HUMAN [Term] id: CCO:I0008112 name: gps2-setdb1 physical interaction xref: IntAct:EBI-730075 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001746 ! GPS2_HUMAN relationship: has_participant CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:I0008113 name: gstm4-rif1 physical interaction xref: IntAct:EBI-730078 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006144 ! GSTM4_HUMAN [Term] id: CCO:I0008114 name: gstm4-tp53 physical interaction xref: IntAct:EBI-730084 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006144 ! GSTM4_HUMAN [Term] id: CCO:I0008116 name: hbxip-rif1 physical interaction xref: IntAct:EBI-730114 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0041278 ! HBXIP_HUMAN [Term] id: CCO:I0008117 name: hla_dqa1-rif1 physical interaction xref: IntAct:EBI-730117 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006147 ! HA23_HUMAN [Term] id: CCO:I0008118 name: hmg20b-vim physical interaction xref: IntAct:EBI-730126 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002184 ! HM20B_HUMAN relationship: has_participant CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:I0008119 name: hmgb1-rif1 physical interaction xref: IntAct:EBI-730129 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005929 ! HMGB1_HUMAN [Term] id: CCO:I0008120 name: hmox2-rif1 physical interaction xref: IntAct:EBI-730144 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006148 ! HMOX2_HUMAN [Term] id: CCO:I0008123 name: hspb1-rif1 physical interaction xref: IntAct:EBI-730186 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005842 ! HSPB1_HUMAN [Term] id: CCO:I0008124 name: hspb1-tp53 physical interaction xref: IntAct:EBI-730189 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0005842 ! HSPB1_HUMAN [Term] id: CCO:I0008125 name: id2-rif1 physical interaction xref: IntAct:EBI-730207 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006149 ! ID2_HUMAN [Term] id: CCO:I0008126 name: kif15-chd3 physical interaction xref: IntAct:EBI-730243 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002165 ! KIF15_HUMAN relationship: has_participant CCO:B0006082 ! CHD3_HUMAN [Term] id: CCO:I0008127 name: kif15-vim physical interaction xref: IntAct:EBI-730246 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002165 ! KIF15_HUMAN relationship: has_participant CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:I0008130 name: mad2l1bp-eef1a1 physical interaction xref: IntAct:EBI-730288 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN relationship: has_participant CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:I0008131 name: mad2l1bp-htatip physical interaction xref: IntAct:EBI-730291 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN relationship: has_participant CCO:B0005351 ! TIP60_HUMAN [Term] id: CCO:I0008132 name: mad2l1bp-ptn physical interaction xref: IntAct:EBI-730294 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001541 ! PTN_HUMAN relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN [Term] id: CCO:I0008133 name: mad2l1bp-setdb1 physical interaction xref: IntAct:EBI-730297 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN relationship: has_participant CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:I0008134 name: mphosph6-rif1 physical interaction xref: IntAct:EBI-730339 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0002071 ! MPH6_HUMAN [Term] id: CCO:I0008135 name: mphosph6-unc119 physical interaction xref: IntAct:EBI-730342 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0006080 ! UN119_HUMAN [Term] id: CCO:I0008136 name: mphosph6-zhx1 physical interaction xref: IntAct:EBI-730345 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0005395 ! ZHX1_HUMAN [Term] id: CCO:I0008137 name: nme3-nme2 physical interaction xref: IntAct:EBI-730402 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001546 ! NDKB_HUMAN relationship: has_participant CCO:B0005316 ! NDK3_HUMAN [Term] id: CCO:I0008138 name: np-tp53 physical interaction xref: IntAct:EBI-730408 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006097 ! PNPH_HUMAN [Term] id: CCO:I0008140 name: pcdha4-rif1 physical interaction xref: IntAct:EBI-730483 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006099 ! PCDA4_HUMAN [Term] id: CCO:I0008141 name: pdcd5-rif1 physical interaction xref: IntAct:EBI-730495 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006152 ! PDCD5_HUMAN [Term] id: CCO:I0008142 name: pfdn1-med31 physical interaction xref: IntAct:EBI-730501 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0005784 ! MED31_HUMAN [Term] id: CCO:I0008143 name: pfdn1-git1 physical interaction xref: IntAct:EBI-730504 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:I0008144 name: pfdn1-hap1 physical interaction xref: IntAct:EBI-730507 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0006153 ! HAP1_HUMAN [Term] id: CCO:I0008145 name: pfdn1-kiaa1377 physical interaction xref: IntAct:EBI-730510 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008146 name: pfdn1-rif1 physical interaction xref: IntAct:EBI-730513 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008147 name: pfdn1-rplp1 physical interaction xref: IntAct:EBI-730516 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0005770 ! RLA1_HUMAN [Term] id: CCO:I0008148 name: pfn1-rif1 physical interaction xref: IntAct:EBI-730522 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006154 ! PROF1_HUMAN [Term] id: CCO:I0008149 name: pmf1-cops6 physical interaction xref: IntAct:EBI-730531 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001912 ! PMF1_HUMAN relationship: has_participant CCO:B0006133 ! CSN6_HUMAN [Term] id: CCO:I0008150 name: pmf1-git1 physical interaction xref: IntAct:EBI-730534 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001912 ! PMF1_HUMAN relationship: has_participant CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:I0008151 name: sept5-pfn2 physical interaction xref: IntAct:EBI-730537 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN relationship: has_participant CCO:B0006155 ! PROF2_HUMAN [Term] id: CCO:I0008152 name: prei3-mcm2 physical interaction xref: IntAct:EBI-730585 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0031198 ! MOBL3_HUMAN [Term] id: CCO:I0008153 name: prei3-rif1 physical interaction xref: IntAct:EBI-730594 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0031198 ! MOBL3_HUMAN [Term] id: CCO:I0008154 name: psg9-rif1 physical interaction xref: IntAct:EBI-730612 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006157 ! PSG9_HUMAN [Term] id: CCO:I0008155 name: rad51-vim physical interaction xref: IntAct:EBI-730657 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001721 ! RAD51_HUMAN relationship: has_participant CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:I0008156 name: rbm5-rif1 physical interaction xref: IntAct:EBI-730660 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001660 ! RBM5_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008157 name: rgs2-ddr1 physical interaction xref: IntAct:EBI-730672 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006158 ! DDR1_HUMAN [Term] id: CCO:I0008158 name: rgs2-hspa8 physical interaction xref: IntAct:EBI-730675 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0005699 ! HSP7C_HUMAN [Term] id: CCO:I0008159 name: s100a8-rif1 physical interaction xref: IntAct:EBI-730729 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006159 ! S10A8_HUMAN [Term] id: CCO:I0008164 name: snrpn-rif1 physical interaction xref: IntAct:EBI-730882 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006111 ! RSMN_HUMAN [Term] id: CCO:I0008165 name: socs3-pin1 physical interaction xref: IntAct:EBI-730888 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0006162 ! SOCS3_HUMAN [Term] id: CCO:I0008166 name: src-khdrbs1 physical interaction xref: IntAct:EBI-730897 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0005464 ! SRC_HUMAN [Term] id: CCO:I0008168 name: stx5a-tp53 physical interaction xref: IntAct:EBI-730918 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006164 ! STX5_HUMAN [Term] id: CCO:I0008169 name: sult1e1-rif1 physical interaction xref: IntAct:EBI-730924 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006112 ! ST1E1_HUMAN [Term] id: CCO:I0008170 name: supt5h-kiaa1377 physical interaction xref: IntAct:EBI-730930 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008171 name: supt5h-rpl8 physical interaction xref: IntAct:EBI-730933 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0005860 ! RL8_HUMAN [Term] id: CCO:I0008172 name: terf1-git1 physical interaction xref: IntAct:EBI-730945 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0005397 ! GIT1_HUMAN [Term] id: CCO:I0008173 name: terf1-pfn2 physical interaction xref: IntAct:EBI-730948 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0006155 ! PROF2_HUMAN [Term] id: CCO:I0008174 name: terf1-zhx1 physical interaction xref: IntAct:EBI-730951 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0005395 ! ZHX1_HUMAN [Term] id: CCO:I0008175 name: tmsb4x-rif1 physical interaction xref: IntAct:EBI-731005 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006115 ! TYB4_HUMAN [Term] id: CCO:I0008176 name: pbk-gps2 physical interaction xref: IntAct:EBI-731026 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001746 ! GPS2_HUMAN relationship: has_participant CCO:B0002045 ! TOPK_HUMAN [Term] id: CCO:I0008177 name: tp53ap1-tp53 physical interaction xref: IntAct:EBI-731029 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006165 ! Q52MB0_HUMAN [Term] id: CCO:I0008178 name: tp53bp2-eef1a1 physical interaction xref: IntAct:EBI-731032 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:I0008179 name: tp53bp2-kif5a physical interaction xref: IntAct:EBI-731035 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0006166 ! KIF5A_HUMAN [Term] id: CCO:I0008180 name: tp53bp2-ptn physical interaction xref: IntAct:EBI-731038 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001541 ! PTN_HUMAN relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN [Term] id: CCO:I0008181 name: tp53bp2-utp14a physical interaction xref: IntAct:EBI-731041 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:I0008182 name: tp53bp2-unc119 physical interaction xref: IntAct:EBI-731044 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0006080 ! UN119_HUMAN [Term] id: CCO:I0008183 name: tubb4-khdrbs1 physical interaction xref: IntAct:EBI-731071 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0006167 ! TBB4_HUMAN [Term] id: CCO:I0008184 name: ube2i-unc119 physical interaction xref: IntAct:EBI-731083 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0006080 ! UN119_HUMAN [Term] id: CCO:I0008186 name: vim-rif1 physical interaction xref: IntAct:EBI-731104 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:I0008187 name: wdr33-tp53 physical interaction xref: IntAct:EBI-731113 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006169 ! WDR33_HUMAN [Term] id: CCO:I0008188 name: klhlx-rif1 physical interaction xref: IntAct:EBI-731158 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006170 ! Q5ZF45_HUMAN [Term] id: CCO:I0008189 name: arhh-rif1 physical interaction xref: IntAct:EBI-731218 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006171 ! Q6ICP4_HUMAN [Term] id: CCO:I0008191 name: arpc3-cdkn2b physical interaction xref: IntAct:EBI-731245 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001616 ! CDN2B_HUMAN relationship: has_participant CCO:B0006172 ! ARPC3_HUMAN [Term] id: CCO:I0008192 name: atf3-rif1 physical interaction xref: IntAct:EBI-731302 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006121 ! ATF3_HUMAN [Term] id: CCO:I0008193 name: atp1b1-rif1 physical interaction xref: IntAct:EBI-731305 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005453 ! AT1B1_HUMAN [Term] id: CCO:I0008194 name: atp5c1-ccnd3 physical interaction xref: IntAct:EBI-731308 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0006122 ! ATPG_HUMAN [Term] id: CCO:I0008197 name: axin1-axin1 physical interaction xref: IntAct:EBI-731362 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001367 ! AXN1_HUMAN [Term] id: CCO:I0008198 name: axin1-gak physical interaction xref: IntAct:EBI-731365 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001364 ! GAK_HUMAN relationship: has_participant CCO:B0001367 ! AXN1_HUMAN [Term] id: CCO:I0008199 name: axin1-utp14a physical interaction xref: IntAct:EBI-731368 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001367 ! AXN1_HUMAN relationship: has_participant CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:I0008200 name: bcar1-ppp1r15a physical interaction xref: IntAct:EBI-731386 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001436 ! PR15A_HUMAN relationship: has_participant CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:I0008202 name: brms1-eef1a1 physical interaction xref: IntAct:EBI-731416 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:I0008203 name: brms1-rif1 physical interaction xref: IntAct:EBI-731419 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN [Term] id: CCO:I0008205 name: c19orf14-rif1 physical interaction xref: IntAct:EBI-731458 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006173 ! WDR62_HUMAN [Term] id: CCO:I0008206 name: ubqln4-smarcb1 physical interaction xref: IntAct:EBI-731464 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0005619 ! UBQL4_HUMAN [Term] id: CCO:I0008207 name: c7orf20-plk1 physical interaction xref: IntAct:EBI-731482 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001663 ! PLK1_HUMAN relationship: has_participant CCO:B0006174 ! CG020_HUMAN [Term] id: CCO:I0008212 name: cdkn2b-ikbkap physical interaction xref: IntAct:EBI-731545 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001616 ! CDN2B_HUMAN relationship: has_participant CCO:B0005398 ! ELP1_HUMAN [Term] id: CCO:I0008213 name: cdkn2c-aplp1 physical interaction xref: IntAct:EBI-731551 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0006179 ! APLP1_HUMAN [Term] id: CCO:I0008214 name: cdkn2c-cops6 physical interaction xref: IntAct:EBI-731554 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0006133 ! CSN6_HUMAN [Term] id: CCO:I0008215 name: cdkn2c-gdf9 physical interaction xref: IntAct:EBI-731557 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0006180 ! GDF9_HUMAN [Term] id: CCO:I0008217 name: cradd-rif1 physical interaction xref: IntAct:EBI-731632 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006182 ! CRADD_HUMAN [Term] id: CCO:I0008218 name: ddx24-pin1 physical interaction xref: IntAct:EBI-731674 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0006183 ! DDX24_HUMAN [Term] id: CCO:I0008219 name: dleu1-psma1 physical interaction xref: IntAct:EBI-731695 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0005233 ! PSA1_HUMAN [Term] id: CCO:I0008220 name: dleu1-setdb1 physical interaction xref: IntAct:EBI-731698 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:I0008221 name: dleu1-shmt1 physical interaction xref: IntAct:EBI-731701 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0006184 ! GLYC_HUMAN [Term] id: CCO:I0008222 name: dleu1-tle1 physical interaction xref: IntAct:EBI-731704 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0005511 ! TLE1_HUMAN [Term] id: CCO:I0008225 name: egfl6-sh3gl3 physical interaction xref: IntAct:EBI-731773 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001947 ! EGFL6_HUMAN relationship: has_participant CCO:B0006187 ! SH3G3_HUMAN [Term] id: CCO:I0008227 name: ep300-cops6 physical interaction xref: IntAct:EBI-731824 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0006133 ! CSN6_HUMAN [Term] id: CCO:I0008231 name: ethe1-rif1 physical interaction xref: IntAct:EBI-731848 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006189 ! ETHE1_HUMAN [Term] id: CCO:I0008232 name: fgfr3-centd2 physical interaction xref: IntAct:EBI-731866 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002052 ! CEND2_HUMAN relationship: has_participant CCO:B0005920 ! FGFR3_HUMAN [Term] id: CCO:I0008234 name: flj20364-gps2 physical interaction xref: IntAct:EBI-731917 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001746 ! GPS2_HUMAN relationship: has_participant CCO:B0006191 ! CCD99_HUMAN [Term] id: CCO:I0008235 name: smpd3-med31 physical interaction xref: IntAct:EBI-731944 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002175 ! NSMA2_HUMAN relationship: has_participant CCO:B0005784 ! MED31_HUMAN [Term] id: CCO:I0008236 name: smpd3-cops6 physical interaction xref: IntAct:EBI-731947 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002175 ! NSMA2_HUMAN relationship: has_participant CCO:B0006133 ! CSN6_HUMAN [Term] id: CCO:I0008237 name: smpd3-crmp1 physical interaction xref: IntAct:EBI-731950 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002175 ! NSMA2_HUMAN relationship: has_participant CCO:B0006074 ! DPYL1_HUMAN [Term] id: CCO:I0008238 name: smpd3-dkfzp564o0523 physical interaction xref: IntAct:EBI-731953 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002175 ! NSMA2_HUMAN relationship: has_participant CCO:B0035954 ! YG012_HUMAN [Term] id: CCO:I0008239 name: smpd3-g22p1 physical interaction xref: IntAct:EBI-731956 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002175 ! NSMA2_HUMAN relationship: has_participant CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:I0008240 name: smpd3-gdf9 physical interaction xref: IntAct:EBI-731959 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002175 ! NSMA2_HUMAN relationship: has_participant CCO:B0006180 ! GDF9_HUMAN [Term] id: CCO:I0008241 name: smpd3-rif1 physical interaction xref: IntAct:EBI-731965 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0002175 ! NSMA2_HUMAN [Term] id: CCO:I0008242 name: smpd3-setdb1 physical interaction xref: IntAct:EBI-731968 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002175 ! NSMA2_HUMAN relationship: has_participant CCO:B0005404 ! SETB1_HUMAN [Term] id: CCO:I0008244 name: gc-rif1 physical interaction xref: IntAct:EBI-732010 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006193 ! VTDB_HUMAN [Term] id: CCO:I0008249 name: hspb3-rif1 physical interaction xref: IntAct:EBI-732175 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006197 ! HSPB3_HUMAN [Term] id: CCO:I0008250 name: hspbp1-rif1 physical interaction xref: IntAct:EBI-732187 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005199 ! HPBP1_HUMAN [Term] id: CCO:I0008251 name: ilf3-gdf9 physical interaction xref: IntAct:EBI-732235 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001734 ! ILF3_HUMAN relationship: has_participant CCO:B0006180 ! GDF9_HUMAN [Term] id: CCO:I0008252 name: itgb3bp-rif1 physical interaction xref: IntAct:EBI-732250 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006198 ! CENPR_HUMAN [Term] id: CCO:I0008254 name: kibra-rif1 physical interaction xref: IntAct:EBI-732309 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006200 ! WWC1_HUMAN [Term] id: CCO:I0008255 name: kif22-gdf9 physical interaction xref: IntAct:EBI-732315 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001792 ! KIF22_HUMAN relationship: has_participant CCO:B0006180 ! GDF9_HUMAN [Term] id: CCO:I0008256 name: kif22-immt physical interaction xref: IntAct:EBI-732318 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001792 ! KIF22_HUMAN relationship: has_participant CCO:B0006201 ! IMMT_HUMAN [Term] id: CCO:I0008257 name: kif22-pja1 physical interaction xref: IntAct:EBI-732321 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001792 ! KIF22_HUMAN relationship: has_participant CCO:B0006202 ! PJA1_HUMAN [Term] id: CCO:I0008258 name: kntc2-tom1l1 physical interaction xref: IntAct:EBI-732324 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0006203 ! TM1L1_HUMAN [Term] id: CCO:I0008259 name: lepr-pin1 physical interaction xref: IntAct:EBI-732336 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0005902 ! LEPR_HUMAN [Term] id: CCO:I0008260 name: mad2l1bp-kiaa1377 physical interaction xref: IntAct:EBI-732407 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008261 name: mad2l1bp-igsf21 physical interaction xref: IntAct:EBI-732410 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN relationship: has_participant CCO:B0006168 ! IGS21_HUMAN [Term] id: CCO:I0008262 name: mad2l1bp-rif1 physical interaction xref: IntAct:EBI-732413 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008263 name: maged1-plk1 physical interaction xref: IntAct:EBI-732431 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001663 ! PLK1_HUMAN relationship: has_participant CCO:B0006204 ! MAGD1_HUMAN [Term] id: CCO:I0008264 name: mcm2-rps4x physical interaction xref: IntAct:EBI-732464 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0001691 ! RS4X_HUMAN [Term] id: CCO:I0008265 name: c16orf24-tp53 physical interaction xref: IntAct:EBI-732491 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006205 ! CP024_HUMAN [Term] id: CCO:I0008267 name: mllt3-rif1 physical interaction xref: IntAct:EBI-732530 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006206 ! AF9_HUMAN [Term] id: CCO:I0008268 name: mnat1-cops6 physical interaction xref: IntAct:EBI-732533 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001653 ! MAT1_HUMAN relationship: has_participant CCO:B0006133 ! CSN6_HUMAN [Term] id: CCO:I0008269 name: mnat1-dkfzp564o0523 physical interaction xref: IntAct:EBI-732536 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001653 ! MAT1_HUMAN relationship: has_participant CCO:B0035954 ! YG012_HUMAN [Term] id: CCO:I0008270 name: mnat1-eef1a1 physical interaction xref: IntAct:EBI-732539 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001653 ! MAT1_HUMAN relationship: has_participant CCO:B0005831 ! EF1A1_HUMAN [Term] id: CCO:I0008271 name: mnat1-rif1 physical interaction xref: IntAct:EBI-732542 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001653 ! MAT1_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008272 name: mphosph6-aplp1 physical interaction xref: IntAct:EBI-732545 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0006179 ! APLP1_HUMAN [Term] id: CCO:I0008273 name: mphosph6-dkfzp564o05 physical interaction xref: IntAct:EBI-732548 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0035954 ! YG012_HUMAN [Term] id: CCO:I0008274 name: mphosph6-gdf9 physical interaction xref: IntAct:EBI-732551 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0006180 ! GDF9_HUMAN [Term] id: CCO:I0008275 name: mpp3-mcm2 physical interaction xref: IntAct:EBI-732557 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0006207 ! MPP3_HUMAN [Term] id: CCO:I0008276 name: mrps6-rif1 physical interaction xref: IntAct:EBI-732569 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006208 ! RT06_HUMAN [Term] id: CCO:I0008279 name: nasp-luc7l2 physical interaction xref: IntAct:EBI-732611 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001626 ! NASP_HUMAN relationship: has_participant CCO:B0006150 ! LC7L2_HUMAN [Term] id: CCO:I0008283 name: nhp2l1-rif1 physical interaction xref: IntAct:EBI-732650 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001676 ! NH2L1_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008284 name: paep-rif1 physical interaction xref: IntAct:EBI-732716 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006212 ! PAEP_HUMAN [Term] id: CCO:I0008286 name: pfdn1-hip1 physical interaction xref: IntAct:EBI-732797 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0006214 ! HIP1_HUMAN [Term] id: CCO:I0008287 name: pfdn1-immt physical interaction xref: IntAct:EBI-732800 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0006201 ! IMMT_HUMAN [Term] id: CCO:I0008288 name: pfdn1-psme1 physical interaction xref: IntAct:EBI-732803 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0006215 ! PSME1_HUMAN [Term] id: CCO:I0008290 name: plekha4-rif1 physical interaction xref: IntAct:EBI-732866 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006216 ! PKHA4_HUMAN [Term] id: CCO:I0008291 name: pmf1-med31 physical interaction xref: IntAct:EBI-732878 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001912 ! PMF1_HUMAN relationship: has_participant CCO:B0005784 ! MED31_HUMAN [Term] id: CCO:I0008292 name: pmf1-crmp1 physical interaction xref: IntAct:EBI-732881 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001912 ! PMF1_HUMAN relationship: has_participant CCO:B0006074 ! DPYL1_HUMAN [Term] id: CCO:I0008293 name: pmf1-ptn physical interaction xref: IntAct:EBI-732884 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001541 ! PTN_HUMAN relationship: has_participant CCO:B0001912 ! PMF1_HUMAN [Term] id: CCO:I0008294 name: sept5-myst2 physical interaction xref: IntAct:EBI-732887 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN relationship: has_participant CCO:B0005399 ! MYST2_HUMAN [Term] id: CCO:I0008295 name: pold1-chgb physical interaction xref: IntAct:EBI-732896 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:I0008296 name: pold1-kiaa1377 physical interaction xref: IntAct:EBI-732899 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008297 name: ppp5c-cse1l physical interaction xref: IntAct:EBI-732935 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001662 ! PPP5_HUMAN relationship: has_participant CCO:B0005662 ! XPO2_HUMAN [Term] id: CCO:I0008298 name: pqbp1-rif1 physical interaction xref: IntAct:EBI-732938 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006218 ! PQBP1_HUMAN [Term] id: CCO:I0008300 name: psmb10-ptn physical interaction xref: IntAct:EBI-732971 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001541 ! PTN_HUMAN relationship: has_participant CCO:B0006219 ! PSB10_HUMAN [Term] id: CCO:I0008301 name: pten-ang physical interaction xref: IntAct:EBI-733007 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0006220 ! ANGI_HUMAN [Term] id: CCO:I0008302 name: pten-chgb physical interaction xref: IntAct:EBI-733010 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0006217 ! SCG1_HUMAN [Term] id: CCO:I0008303 name: pten-cops6 physical interaction xref: IntAct:EBI-733013 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0006133 ! CSN6_HUMAN [Term] id: CCO:I0008304 name: pten-hba1 physical interaction xref: IntAct:EBI-733016 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0006221 ! HBA_HUMAN [Term] id: CCO:I0008305 name: rab1a-cdkn1a physical interaction xref: IntAct:EBI-733058 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0006222 ! RAB1A_HUMAN [Term] id: CCO:I0008306 name: rab27a-rif1 physical interaction xref: IntAct:EBI-733079 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006223 ! RB27A_HUMAN [Term] id: CCO:I0008307 name: ran-kiaa1377 physical interaction xref: IntAct:EBI-733094 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008308 name: recql5-plk1 physical interaction xref: IntAct:EBI-733100 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001663 ! PLK1_HUMAN relationship: has_participant CCO:B0006224 ! RECQ5_HUMAN [Term] id: CCO:I0008309 name: rgs2-arfgap1 physical interaction xref: IntAct:EBI-733121 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006225 ! ARFG1_HUMAN [Term] id: CCO:I0008310 name: rgs2-dncl1 physical interaction xref: IntAct:EBI-733124 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006226 ! DYL1_HUMAN [Term] id: CCO:I0008311 name: rgs2-park2 physical interaction xref: IntAct:EBI-733127 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006227 ! PRKN2_HUMAN [Term] id: CCO:I0008312 name: rgs2-prkcsh physical interaction xref: IntAct:EBI-733130 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006228 ! GLU2B_HUMAN [Term] id: CCO:I0008314 name: rit1-rif1 physical interaction xref: IntAct:EBI-733136 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006229 ! RIT1_HUMAN [Term] id: CCO:I0008315 name: rnf10-rif1 physical interaction xref: IntAct:EBI-733142 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006230 ! RNF10_HUMAN [Term] id: CCO:I0008317 name: rpl37a-rif1 physical interaction xref: IntAct:EBI-733166 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006231 ! RL37A_HUMAN [Term] id: CCO:I0008318 name: rrm1-rif1 physical interaction xref: IntAct:EBI-733190 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006232 ! RIR1_HUMAN [Term] id: CCO:I0008319 name: s100a8-tp53 physical interaction xref: IntAct:EBI-733223 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006159 ! S10A8_HUMAN [Term] id: CCO:I0008320 name: pnn-pdpk1 physical interaction xref: IntAct:EBI-733277 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002131 ! PININ_HUMAN relationship: has_participant CCO:B0006233 ! PDPK1_HUMAN [Term] id: CCO:I0008321 name: snapap-spag5 physical interaction xref: IntAct:EBI-733343 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002058 ! SPAG5_HUMAN relationship: has_participant CCO:B0006234 ! S25BP_HUMAN [Term] id: CCO:I0008323 name: spg7-rif1 physical interaction xref: IntAct:EBI-733364 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006236 ! SPG7_HUMAN [Term] id: CCO:I0008326 name: stx5a-rif1 physical interaction xref: IntAct:EBI-733418 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006164 ! STX5_HUMAN [Term] id: CCO:I0008327 name: supt5h-c9orf78 physical interaction xref: IntAct:EBI-733430 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0006238 ! Q6GVN4_HUMAN [Term] id: CCO:I0008328 name: supt5h-gtf3c1 physical interaction xref: IntAct:EBI-733433 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0006211 ! TF3C1_HUMAN [Term] id: CCO:I0008329 name: supt5h-ik physical interaction xref: IntAct:EBI-733436 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0006239 ! RED_HUMAN [Term] id: CCO:I0008330 name: supt5h-loc56902 physical interaction xref: IntAct:EBI-733439 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0006240 ! PNO1_HUMAN [Term] id: CCO:I0008331 name: supt5h-phyhip physical interaction xref: IntAct:EBI-733442 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0006241 ! PHYIP_HUMAN [Term] id: CCO:I0008332 name: supt5h-ppia physical interaction xref: IntAct:EBI-733445 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0006072 ! PPIA_HUMAN [Term] id: CCO:I0008336 name: tdgf1-rif1 physical interaction xref: IntAct:EBI-733517 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006244 ! TDGF1_HUMAN [Term] id: CCO:I0008337 name: terf1-utp14a physical interaction xref: IntAct:EBI-733520 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:I0008338 name: terf1-tinf2 physical interaction xref: IntAct:EBI-733523 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0006245 ! TINF2_HUMAN [Term] id: CCO:I0008339 name: tgif-rif1 physical interaction xref: IntAct:EBI-733538 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006246 ! TGIF1_HUMAN [Term] id: CCO:I0008340 name: tm4sf6-rif1 physical interaction xref: IntAct:EBI-733565 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006247 ! Q6IAN9_HUMAN [Term] id: CCO:I0008341 name: tnfrsf6-rif1 physical interaction xref: IntAct:EBI-733583 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0005479 ! TNR6_HUMAN [Term] id: CCO:I0008342 name: pbk-kiaa1377 physical interaction xref: IntAct:EBI-733607 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002045 ! TOPK_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008343 name: tp53bp2-mrpl20 physical interaction xref: IntAct:EBI-733610 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0006248 ! RM20_HUMAN [Term] id: CCO:I0008344 name: tpd52l1-c7orf36 physical interaction xref: IntAct:EBI-733613 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0006249 ! CG036_HUMAN [Term] id: CCO:I0008345 name: tpd52l1-eif3s1 physical interaction xref: IntAct:EBI-733616 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0026278 ! EIF3J_HUMAN [Term] id: CCO:I0008346 name: trbv21_1-rif1 physical interaction xref: IntAct:EBI-733625 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006251 ! Q8N3Z8_HUMAN [Term] id: CCO:I0008348 name: ube1c-chd3 physical interaction xref: IntAct:EBI-733684 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001989 ! UBA3_HUMAN relationship: has_participant CCO:B0006082 ! CHD3_HUMAN [Term] id: CCO:I0008349 name: ube2v2-rif1 physical interaction xref: IntAct:EBI-733687 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001813 ! UB2V2_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008350 name: ulk2-nasp physical interaction xref: IntAct:EBI-733695 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001626 ! NASP_HUMAN relationship: has_participant CCO:B0006252 ! ULK2_HUMAN [Term] id: CCO:I0008351 name: zcchc10-tp53 physical interaction xref: IntAct:EBI-733737 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006253 ! ZCH10_HUMAN [Term] id: CCO:I0008353 name: klhlx-pin1 physical interaction xref: IntAct:EBI-733758 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0006170 ! Q5ZF45_HUMAN [Term] id: CCO:I0008355 name: arf4l-eml4 physical interaction xref: IntAct:EBI-733843 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002144 ! EMAL4_HUMAN relationship: has_participant CCO:B0006256 ! ARL4D_HUMAN [Term] id: CCO:I0008356 name: arhgdia-cdkn1b physical interaction xref: IntAct:EBI-733864 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0032833 ! GDIR1_HUMAN [Term] id: CCO:I0008357 name: arih2-eml4 physical interaction xref: IntAct:EBI-733873 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002144 ! EMAL4_HUMAN relationship: has_participant CCO:B0005288 ! ARI2_HUMAN [Term] id: CCO:I0008358 name: arpc3-centd2 physical interaction xref: IntAct:EBI-733895 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002052 ! CEND2_HUMAN relationship: has_participant CCO:B0006172 ! ARPC3_HUMAN [Term] id: CCO:I0008360 name: atp5c1-egfr physical interaction xref: IntAct:EBI-733962 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0006122 ! ATPG_HUMAN [Term] id: CCO:I0008361 name: bcar1-e2f2 physical interaction xref: IntAct:EBI-734012 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001781 ! E2F2_HUMAN relationship: has_participant CCO:B0005841 ! BCAR1_HUMAN [Term] id: CCO:I0008362 name: boc-rif1 physical interaction xref: IntAct:EBI-734021 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0006259 ! BOC_HUMAN [Term] id: CCO:I0008363 name: ubqln4-appbp1 physical interaction xref: IntAct:EBI-734060 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001758 ! ULA1_HUMAN relationship: has_participant CCO:B0005619 ! UBQL4_HUMAN [Term] id: CCO:I0008364 name: c2f-khdrbs1 physical interaction xref: IntAct:EBI-734066 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0006260 ! NEP1_HUMAN [Term] id: CCO:I0008365 name: c7orf20-cdkn1a physical interaction xref: IntAct:EBI-734078 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0006174 ! CG020_HUMAN [Term] id: CCO:I0008369 name: cdca5-g22p1 physical interaction xref: IntAct:EBI-734138 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002038 ! CDCA5_HUMAN relationship: has_participant CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:I0008370 name: cdk5rap3-crmp1 physical interaction xref: IntAct:EBI-734145 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002044 ! CK5P3_HUMAN relationship: has_participant CCO:B0006074 ! DPYL1_HUMAN [Term] id: CCO:I0008371 name: cdkn1a-gnb2l1 physical interaction xref: IntAct:EBI-734149 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0005739 ! GBLP_HUMAN [Term] id: CCO:I0008372 name: cdkn1a-hdac11 physical interaction xref: IntAct:EBI-734152 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0005701 ! HDA11_HUMAN [Term] id: CCO:I0008373 name: centd2-g22p1 physical interaction xref: IntAct:EBI-734161 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002052 ! CEND2_HUMAN relationship: has_participant CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:I0008375 name: chfr-eef1g physical interaction xref: IntAct:EBI-734167 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002035 ! CHFR_HUMAN relationship: has_participant CCO:B0006079 ! EF1G_HUMAN [Term] id: CCO:I0008379 name: cutl1-bin1 physical interaction xref: IntAct:EBI-734215 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001349 ! BIN1_HUMAN relationship: has_participant CCO:B0040687 ! CUX1_HUMAN [Term] id: CCO:I0008381 name: dleu1-abcd4 physical interaction xref: IntAct:EBI-734338 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0006268 ! ABCD4_HUMAN [Term] id: CCO:I0008382 name: dleu1-gdf9 physical interaction xref: IntAct:EBI-734344 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0006180 ! GDF9_HUMAN [Term] id: CCO:I0008383 name: dnm2-bat1 physical interaction xref: IntAct:EBI-734365 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0005899 ! UAP56_HUMAN [Term] id: CCO:I0008385 name: egfl6-sh3gl2 physical interaction xref: IntAct:EBI-734409 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001947 ! EGFL6_HUMAN relationship: has_participant CCO:B0006188 ! SH3G2_HUMAN [Term] id: CCO:I0008386 name: eno2-ube2c physical interaction xref: IntAct:EBI-734442 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001354 ! UBE2C_HUMAN relationship: has_participant CCO:B0006270 ! ENOG_HUMAN [Term] id: CCO:I0008387 name: fgfr3-flj22624 physical interaction xref: IntAct:EBI-734499 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001914 ! BORA_HUMAN relationship: has_participant CCO:B0005920 ! FGFR3_HUMAN [Term] id: CCO:I0008389 name: flj22624-fez1 physical interaction xref: IntAct:EBI-734587 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001914 ! BORA_HUMAN relationship: has_participant CCO:B0005393 ! FEZ1_HUMAN [Term] id: CCO:I0008391 name: golgb1-brms1 physical interaction xref: IntAct:EBI-734673 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0006272 ! GOGB1_HUMAN [Term] id: CCO:I0008392 name: gpaa1-pin1 physical interaction xref: IntAct:EBI-734706 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0006273 ! GPAA1_HUMAN [Term] id: CCO:I0008393 name: gps2-golga2 physical interaction xref: IntAct:EBI-734709 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001746 ! GPS2_HUMAN relationship: has_participant CCO:B0006274 ! GOGA2_HUMAN [Term] id: CCO:I0008395 name: hmg20b-hnrpl physical interaction xref: IntAct:EBI-734760 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002184 ! HM20B_HUMAN relationship: has_participant CCO:B0006275 ! HNRPL_HUMAN [Term] id: CCO:I0008396 name: hmg20b-tacc2 physical interaction xref: IntAct:EBI-734763 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002184 ! HM20B_HUMAN relationship: has_participant CCO:B0006276 ! TACC2_HUMAN [Term] id: CCO:I0008397 name: hnrph3-pim2 physical interaction xref: IntAct:EBI-734778 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002185 ! PIM2_HUMAN relationship: has_participant CCO:B0006277 ! HNRH3_HUMAN [Term] id: CCO:I0008400 name: kars-pafah1b1 physical interaction xref: IntAct:EBI-734890 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001618 ! LIS1_HUMAN relationship: has_participant CCO:B0006279 ! SYK_HUMAN [Term] id: CCO:I0008401 name: kiaa0087-tp53 physical interaction xref: IntAct:EBI-734908 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006280 ! K0087_HUMAN [Term] id: CCO:I0008402 name: klk10-rif1 physical interaction xref: IntAct:EBI-734929 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001383 ! KLK10_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN [Term] id: CCO:I0008403 name: kif15-map1lc3a physical interaction xref: IntAct:EBI-734932 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002165 ! KIF15_HUMAN relationship: has_participant CCO:B0006281 ! MLP3A_HUMAN [Term] id: CCO:I0008405 name: mad2l1bp-trip13-1 physical interaction xref: IntAct:EBI-735031 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN relationship: has_participant CCO:B0006283 ! TRP13_HUMAN [Term] id: CCO:I0008407 name: mlf1-grik5 physical interaction xref: IntAct:EBI-735133 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001684 ! MLF1_HUMAN relationship: has_participant CCO:B0006285 ! GRIK5_HUMAN [Term] id: CCO:I0008408 name: mnat1-hps6 physical interaction xref: IntAct:EBI-735136 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001653 ! MAT1_HUMAN relationship: has_participant CCO:B0006286 ! HPS6_HUMAN [Term] id: CCO:I0008409 name: mphosph6-c14orf1 physical interaction xref: IntAct:EBI-735139 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0006287 ! ERG28_HUMAN [Term] id: CCO:I0008412 name: ndufb8-pim2 physical interaction xref: IntAct:EBI-735208 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002185 ! PIM2_HUMAN relationship: has_participant CCO:B0006289 ! NDUB8_HUMAN [Term] id: CCO:I0008414 name: pafah1b2-pinx1 physical interaction xref: IntAct:EBI-735300 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002033 ! PINX1_HUMAN relationship: has_participant CCO:B0006291 ! PA1B2_HUMAN [Term] id: CCO:I0008415 name: park2-rad1 physical interaction xref: IntAct:EBI-735321 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001413 ! RAD1_HUMAN relationship: has_participant CCO:B0006227 ! PRKN2_HUMAN [Term] id: CCO:I0008416 name: phyhip-skb1 physical interaction xref: IntAct:EBI-735375 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001357 ! ANM5_HUMAN relationship: has_participant CCO:B0006241 ! PHYIP_HUMAN [Term] id: CCO:I0008419 name: pmf1-gdf9 physical interaction xref: IntAct:EBI-735405 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001912 ! PMF1_HUMAN relationship: has_participant CCO:B0006180 ! GDF9_HUMAN [Term] id: CCO:I0008420 name: pmf1-kiaa1377 physical interaction xref: IntAct:EBI-735408 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001912 ! PMF1_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008421 name: ptd004-skb1 physical interaction xref: IntAct:EBI-735495 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001357 ! ANM5_HUMAN relationship: has_participant CCO:B0006293 ! Q53SQ6_HUMAN [Term] id: CCO:I0008422 name: pten-utp14a physical interaction xref: IntAct:EBI-735498 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0006134 ! UT14A_HUMAN [Term] id: CCO:I0008423 name: ptov1-pin1 physical interaction xref: IntAct:EBI-735507 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0006294 ! PTOV1_HUMAN [Term] id: CCO:I0008424 name: rab4a-tp53 physical interaction xref: IntAct:EBI-735569 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006295 ! RAB4A_HUMAN [Term] id: CCO:I0008425 name: rbbp4-g22p1 physical interaction xref: IntAct:EBI-735587 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001727 ! RBBP4_HUMAN relationship: has_participant CCO:B0005410 ! KU70_HUMAN [Term] id: CCO:I0008426 name: recql5-mtss1 physical interaction xref: IntAct:EBI-735602 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001390 ! MTSS1_HUMAN relationship: has_participant CCO:B0006224 ! RECQ5_HUMAN [Term] id: CCO:I0008427 name: rgs2-wdr74 physical interaction xref: IntAct:EBI-735614 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006296 ! WDR74_HUMAN [Term] id: CCO:I0008428 name: rgs2-lrfn1 physical interaction xref: IntAct:EBI-735617 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006297 ! Q8TBS9_HUMAN [Term] id: CCO:I0008429 name: rgs2-nipsnap1 physical interaction xref: IntAct:EBI-735620 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006298 ! NIPS1_HUMAN [Term] id: CCO:I0008430 name: rgs2-vps29 physical interaction xref: IntAct:EBI-735623 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006299 ! VPS29_HUMAN [Term] id: CCO:I0008432 name: ruvbl1-kiaa1377 physical interaction xref: IntAct:EBI-735705 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0005403 ! K1377_HUMAN [Term] id: CCO:I0008434 name: supt5h-dbn1 physical interaction xref: IntAct:EBI-735938 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:I0008437 name: terf1-capns1 physical interaction xref: IntAct:EBI-736004 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0006088 ! CPNS1_HUMAN [Term] id: CCO:I0008438 name: terf1-dlg5 physical interaction xref: IntAct:EBI-736007 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0001993 ! DLG5_HUMAN [Term] id: CCO:I0008439 name: terf1-sh3gl3 physical interaction xref: IntAct:EBI-736013 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0006187 ! SH3G3_HUMAN [Term] id: CCO:I0008440 name: thap8-tp53 physical interaction xref: IntAct:EBI-736031 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0006304 ! THAP8_HUMAN [Term] id: CCO:I0008442 name: tp53bp2-usp4 physical interaction xref: IntAct:EBI-736082 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0006305 ! UBP4_HUMAN [Term] id: CCO:I0008443 name: tpd52l1-gpr135 physical interaction xref: IntAct:EBI-736088 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0006306 ! GP135_HUMAN [Term] id: CCO:I0008444 name: tpd52l1-hdac1 physical interaction xref: IntAct:EBI-736091 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0005484 ! HDAC1_HUMAN [Term] id: CCO:I0008447 name: zcchc10-pin1 physical interaction xref: IntAct:EBI-736193 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0006253 ! ZCH10_HUMAN [Term] id: CCO:I0008448 name: aurkb-tbl3 physical interaction xref: IntAct:EBI-736328 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002040 ! AURKB_HUMAN relationship: has_participant CCO:B0006309 ! TBL3_HUMAN [Term] id: CCO:I0008449 name: axin1-sh3gl1 physical interaction xref: IntAct:EBI-736331 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001367 ! AXN1_HUMAN relationship: has_participant CCO:B0006310 ! SH3G1_HUMAN [Term] id: CCO:I0008450 name: brd4-chfr physical interaction xref: IntAct:EBI-736340 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002035 ! CHFR_HUMAN relationship: has_participant CCO:B0006311 ! BRD4_HUMAN [Term] id: CCO:I0008451 name: c2f-nat6 physical interaction xref: IntAct:EBI-736391 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002026 ! NAT6_HUMAN relationship: has_participant CCO:B0006260 ! NEP1_HUMAN [Term] id: CCO:I0008453 name: cdc2l1-c9orf74 physical interaction xref: IntAct:EBI-736457 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001540 ! CD2L1_HUMAN relationship: has_participant CCO:B0006312 ! URM1_HUMAN [Term] id: CCO:I0008455 name: cdk5rap3-srprb physical interaction xref: IntAct:EBI-736469 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002044 ! CK5P3_HUMAN relationship: has_participant CCO:B0006313 ! SRPRB_HUMAN [Term] id: CCO:I0008456 name: cdkn1a-flj20580 physical interaction xref: IntAct:EBI-736472 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0006314 ! CA123_HUMAN [Term] id: CCO:I0008457 name: cdkn1a-itgb1bp3 physical interaction xref: IntAct:EBI-736475 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0006315 ! NRK2_HUMAN [Term] id: CCO:I0008458 name: cdkn1a-slc25a11 physical interaction xref: IntAct:EBI-736478 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0006316 ! M2OM_HUMAN [Term] id: CCO:I0008459 name: chfr-gabbr1 physical interaction xref: IntAct:EBI-736490 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002035 ! CHFR_HUMAN relationship: has_participant CCO:B0006317 ! GABR1_HUMAN [Term] id: CCO:I0008460 name: chfr-itgae physical interaction xref: IntAct:EBI-736493 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002035 ! CHFR_HUMAN relationship: has_participant CCO:B0006318 ! ITAE_HUMAN [Term] id: CCO:I0008461 name: chfr-wdr47 physical interaction xref: IntAct:EBI-736496 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002035 ! CHFR_HUMAN relationship: has_participant CCO:B0006319 ! WDR47_HUMAN [Term] id: CCO:I0008462 name: css2-pin1 physical interaction xref: IntAct:EBI-736499 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0006320 ! CHSS2_HUMAN [Term] id: CCO:I0008463 name: mtfr1-pin1 physical interaction xref: IntAct:EBI-736502 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0006321 ! MTFR1_HUMAN [Term] id: CCO:I0008465 name: dbn1-nipbl physical interaction xref: IntAct:EBI-736538 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001908 ! NIPBL_HUMAN relationship: has_participant CCO:B0006302 ! DREB_HUMAN [Term] id: CCO:I0008466 name: dctn1-pgam1 physical interaction xref: IntAct:EBI-736541 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001779 ! DCTN1_HUMAN relationship: has_participant CCO:B0006323 ! PGAM1_HUMAN [Term] id: CCO:I0008467 name: dleu1-arl10c physical interaction xref: IntAct:EBI-736622 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0006324 ! ARL8B_HUMAN [Term] id: CCO:I0008469 name: dmwd-ppbp physical interaction xref: IntAct:EBI-736631 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001726 ! DMWD_HUMAN relationship: has_participant CCO:B0035955 ! CXCL7_HUMAN [Term] id: CCO:I0008470 name: dnm2-eif3s6ip physical interaction xref: IntAct:EBI-736643 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0026279 ! IF3EI_HUMAN [Term] id: CCO:I0008471 name: dnm2-pef1 physical interaction xref: IntAct:EBI-736646 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0006326 ! PEF1_HUMAN [Term] id: CCO:I0008472 name: dnm2-ppib physical interaction xref: IntAct:EBI-736649 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0006327 ! PPIB_HUMAN [Term] id: CCO:I0008473 name: fbxo18-pim2 physical interaction xref: IntAct:EBI-736691 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002185 ! PIM2_HUMAN relationship: has_participant CCO:B0006328 ! FBX18_HUMAN [Term] id: CCO:I0008474 name: flj10415-aurkb physical interaction xref: IntAct:EBI-736706 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002040 ! AURKB_HUMAN relationship: has_participant CCO:B0006329 ! ANKZ1_HUMAN [Term] id: CCO:I0008475 name: ftl-gadd45a physical interaction xref: IntAct:EBI-736787 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001552 ! GA45A_HUMAN relationship: has_participant CCO:B0006192 ! FRIL_HUMAN [Term] id: CCO:I0008476 name: fzr1-c7orf25 physical interaction xref: IntAct:EBI-736793 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002229 ! FZR_HUMAN relationship: has_participant CCO:B0006330 ! CG025_HUMAN [Term] id: CCO:I0008477 name: fzr1-dnaja1 physical interaction xref: IntAct:EBI-736796 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002229 ! FZR_HUMAN relationship: has_participant CCO:B0005835 ! DNJA1_HUMAN [Term] id: CCO:I0008479 name: gps1-tbc1d17 physical interaction xref: IntAct:EBI-736880 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001740 ! CSN1_HUMAN relationship: has_participant CCO:B0005279 ! TBC17_HUMAN [Term] id: CCO:I0008480 name: inpp1-lig1 physical interaction xref: IntAct:EBI-736952 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001534 ! DNL1_HUMAN relationship: has_participant CCO:B0006332 ! INPP_HUMAN [Term] id: CCO:I0008481 name: kiaa0998-cdkn1a physical interaction xref: IntAct:EBI-736991 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0006333 ! TTLL5_HUMAN [Term] id: CCO:I0008482 name: lrpap1-ppm1g physical interaction xref: IntAct:EBI-737060 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001375 ! PPM1G_HUMAN relationship: has_participant CCO:B0006334 ! AMRP_HUMAN [Term] id: CCO:I0008483 name: lrsam1-mutyh physical interaction xref: IntAct:EBI-737075 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002205 ! MUTYH_HUMAN relationship: has_participant CCO:B0006335 ! LRSM1_HUMAN [Term] id: CCO:I0008484 name: mgc3731-cdk4 physical interaction xref: IntAct:EBI-737135 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0006336 ! NOL12_HUMAN [Term] id: CCO:I0008485 name: mpz-pinx1 physical interaction xref: IntAct:EBI-737195 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002033 ! PINX1_HUMAN relationship: has_participant CCO:B0006337 ! MYP0_HUMAN [Term] id: CCO:I0008487 name: pfdn1-c20orf39 physical interaction xref: IntAct:EBI-737324 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0041279 ! TM90B_HUMAN [Term] id: CCO:I0008488 name: pfdn1-defa1 physical interaction xref: IntAct:EBI-737327 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0006339 ! DEF1_HUMAN [Term] id: CCO:I0008490 name: pou3f3-ppp1r15a physical interaction xref: IntAct:EBI-737405 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001436 ! PR15A_HUMAN relationship: has_participant CCO:B0006341 ! PO3F3_HUMAN [Term] id: CCO:I0008491 name: prei3-stk11 physical interaction xref: IntAct:EBI-737441 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0031198 ! MOBL3_HUMAN [Term] id: CCO:I0008492 name: rab1a-mapre3 physical interaction xref: IntAct:EBI-737480 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002238 ! MARE3_HUMAN relationship: has_participant CCO:B0006222 ! RAB1A_HUMAN [Term] id: CCO:I0008493 name: rad1-map1lc3b physical interaction xref: IntAct:EBI-737510 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001413 ! RAD1_HUMAN relationship: has_participant CCO:B0006342 ! MLP3B_HUMAN [Term] id: CCO:I0008494 name: ran-nefl physical interaction xref: IntAct:EBI-737516 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0006343 ! NFL_HUMAN [Term] id: CCO:I0008495 name: rassf1-nudt10 physical interaction xref: IntAct:EBI-737537 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002162 ! RASF1_HUMAN relationship: has_participant CCO:B0006344 ! NUD10_HUMAN [Term] id: CCO:I0008496 name: rgs2-ctsb physical interaction xref: IntAct:EBI-737549 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006345 ! CATB_HUMAN [Term] id: CCO:I0008497 name: rgs2-scn5a physical interaction xref: IntAct:EBI-737552 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0006346 ! SCN5A_HUMAN [Term] id: CCO:I0008498 name: rint1-bnip3l physical interaction xref: IntAct:EBI-737555 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001909 ! RINT1_HUMAN relationship: has_participant CCO:B0005714 ! BNI3L_HUMAN [Term] id: CCO:I0008499 name: rint1-sptbn1 physical interaction xref: IntAct:EBI-737558 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001909 ! RINT1_HUMAN relationship: has_participant CCO:B0005604 ! SPTB2_HUMAN [Term] id: CCO:I0008500 name: rint1-xpnpep1 physical interaction xref: IntAct:EBI-737561 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001909 ! RINT1_HUMAN relationship: has_participant CCO:B0006347 ! XPP1_HUMAN [Term] id: CCO:I0008501 name: rpl21-pim2 physical interaction xref: IntAct:EBI-737594 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002185 ! PIM2_HUMAN relationship: has_participant CCO:B0005862 ! RL21_HUMAN [Term] id: CCO:I0008502 name: rpn1-rbbp4 physical interaction xref: IntAct:EBI-737609 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001727 ! RBBP4_HUMAN relationship: has_participant CCO:B0040688 ! RPN1_HUMAN [Term] id: CCO:I0008504 name: pnn-vamp8 physical interaction xref: IntAct:EBI-737654 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002131 ! PININ_HUMAN relationship: has_participant CCO:B0006350 ! VAMP8_HUMAN [Term] id: CCO:I0008505 name: sept3-wbp2 physical interaction xref: IntAct:EBI-737657 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0002198 ! SEPT3_HUMAN relationship: has_participant CCO:B0006351 ! WBP2_HUMAN [Term] id: CCO:I0008506 name: spin-ptn physical interaction xref: IntAct:EBI-737696 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001541 ! PTN_HUMAN relationship: has_participant CCO:B0002262 ! SPIN1_HUMAN [Term] id: CCO:I0008508 name: supt5h-h2afx physical interaction xref: IntAct:EBI-737741 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN [Term] id: CCO:I0008509 name: supt5h-iqwd1 physical interaction xref: IntAct:EBI-737744 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0006353 ! Q9P0U0_HUMAN [Term] id: CCO:I0008510 name: suv39h2-ube2v2 physical interaction xref: IntAct:EBI-737747 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001813 ! UB2V2_HUMAN relationship: has_participant CCO:B0002139 ! SUV92_HUMAN [Term] id: CCO:I0008513 name: tubb4-lig1 physical interaction xref: IntAct:EBI-737816 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0001534 ! DNL1_HUMAN relationship: has_participant CCO:B0006167 ! TBB4_HUMAN [Term] id: CCO:I0008518 name: ikbkg-ddb1 physical interaction xref: IntAct:EBI-361671 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005524 ! NEMO_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:I0008519 name: map3k1-ddb1 physical interaction xref: IntAct:EBI-361998 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005525 ! M3K1_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:I0008520 name: map3k3-ddb1 physical interaction xref: IntAct:EBI-362430 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005526 ! M3K3_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:I0008521 name: tnfrsf1b-ddb1 physical interaction xref: IntAct:EBI-364780 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005535 ! TNR1B_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:I0008522 name: tle2-ddb1 physical interaction xref: IntAct:EBI-1176696 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005657 ! TLE2_HUMAN [Term] id: CCO:I0008523 name: ddb1-ddb2 physical interaction xref: IntAct:EBI-1177665 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005658 ! DDB2_HUMAN [Term] id: CCO:I0008524 name: rbbp5-wdr5-1 physical interaction xref: IntAct:EBI-1177777 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005660 ! RBBP5_HUMAN [Term] id: CCO:I0008525 name: l2dt1-ddb1 physical interaction xref: IntAct:EBI-1178616 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005656 ! DTL_HUMAN [Term] id: CCO:I0008526 name: eed-ddb1 physical interaction xref: IntAct:EBI-1178636 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005659 ! O75530_HUMAN [Term] id: CCO:I0008527 name: ddb1-brap physical interaction comment: Interaction of DDB1 and BRAP identified by Y2H xref: IntAct:EBI-350213 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005471 ! BRAP_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN [Term] id: CCO:I0008528 name: ddb1-cops3 physical interaction comment: Interaction of DDB1 and COPS3 identified by Y2H xref: IntAct:EBI-350580 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0030750 ! CSN3_HUMAN [Term] id: CCO:I0008529 name: cop1-ddb1 physical interaction xref: IntAct:EBI-1176618 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0006001 ! RFWD2_HUMAN [Term] id: CCO:I0008530 name: l2dtl-ddb1 physical interaction xref: IntAct:EBI-1176630 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005656 ! DTL_HUMAN [Term] id: CCO:I0008531 name: wdr57-ddb1 physical interaction xref: IntAct:EBI-1176639 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005996 ! WDR57_HUMAN [Term] id: CCO:I0008532 name: wdr26-ddb1 physical interaction xref: IntAct:EBI-1176662 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005689 ! WDR26_HUMAN [Term] id: CCO:I0008533 name: wdr5b-ddb1 physical interaction xref: IntAct:EBI-1176674 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0006000 ! WDR5B_HUMAN [Term] id: CCO:I0008534 name: wdr5-ddb1 physical interaction xref: IntAct:EBI-1176685 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0005615 ! WDR5_HUMAN [Term] id: CCO:I0008535 name: vamp3-ddb1 physical interaction xref: IntAct:EBI-737843 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0030751 ! VAMP3_HUMAN [Term] id: CCO:I0008542 name: chuk-myh10 physical interaction xref: IntAct:EBI-361179 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005539 ! IKKA_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008543 name: ikbkb-myh10 physical interaction xref: IntAct:EBI-361257 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005522 ! IKKB_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008544 name: ikbke-myh10 physical interaction xref: IntAct:EBI-361323 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005523 ! IKKE_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008545 name: ikbkg-myh10 physical interaction xref: IntAct:EBI-361500 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005524 ! NEMO_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008546 name: map3k1-myh10 physical interaction xref: IntAct:EBI-361860 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005525 ! M3K1_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008547 name: map3k3-myh10 physical interaction xref: IntAct:EBI-362205 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005526 ! M3K3_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008548 name: ripk2-myh10 physical interaction xref: IntAct:EBI-363664 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005216 ! RIPK2_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008549 name: aah62584-myh10 physical interaction xref: IntAct:EBI-363811 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005530 ! Q6P5Y1_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008550 name: tnfrsf1a-myh10 physical interaction xref: IntAct:EBI-364393 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005534 ! TNR1A_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008551 name: tnfrsf1b-myh10 physical interaction xref: IntAct:EBI-364636 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005535 ! TNR1B_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:I0008552 name: strn4-asns physical interaction xref: IntAct:EBI-735893 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006352 ! STRN4_HUMAN relationship: has_participant CCO:B0032819 ! ASNS_HUMAN [Term] id: CCO:I0008561 name: c9orf76-blm-4 colocalization comment: colocalization of BLAP75 and BLM xref: IntAct:EBI-624095 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0005919 ! RMI1_HUMAN [Term] id: CCO:I0008562 name: blm-fen1-2 physical interaction comment: In vivo Co-IP: bait = FEN-1, prey = BLM xref: IntAct:EBI-708230 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0039756 ! FEN1_HUMAN [Term] id: CCO:I0008563 name: blm-fen1-4 physical interaction comment: In vivo Co-IP: bait = BLM, prey = FEN-1 xref: IntAct:EBI-708260 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0039756 ! FEN1_HUMAN [Term] id: CCO:I0008564 name: menin-myh9-1 physical interaction comment: Interaction between human Menin and MYH9 detected by tandem affinity purification xref: IntAct:EBI-1136111 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0019193 ! MYH9_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:I0008565 name: c9orf76-blm-3 physical interaction comment: copurification: BLAP75 and BLM xref: IntAct:EBI-621454 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0005919 ! RMI1_HUMAN [Term] id: CCO:I0008566 name: wrn-blm-11 physical interaction comment: Pull-down using nuclear extracts: bait = WRM, prey = BLM xref: IntAct:EBI-707007 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005358 ! WRN_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0008567 name: menin-myh9-6 physical interaction comment: Cosedimentation of human Menin and MYH9 xref: IntAct:EBI-1148514 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0019193 ! MYH9_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:I0008568 name: rrp4-rnf8 physical interaction xref: IntAct:EBI-373731 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0035936 ! RNF8_HUMAN relationship: has_participant CCO:B0039757 ! EXOS2_HUMAN [Term] id: CCO:I0008569 name: mll-hcfc2-1 physical interaction comment: MLL associates wtih a cohort of proteins, as detected by affinity chromatography. xref: IntAct:EBI-592758 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005486 ! HRX_HUMAN relationship: has_participant CCO:B0005660 ! RBBP5_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN relationship: has_participant CCO:B0036469 ! HCFC2_HUMAN relationship: has_participant CCO:B0039758 ! UTP18_HUMAN [Term] id: CCO:I0008570 name: wrn-blm-4 colocalization comment: Colocalization of WRN and BLM in human U2-OS cells xref: IntAct:EBI-706931 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0005358 ! WRN_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0008571 name: wrn-blm-6 direct interaction comment: Pull-down : bait = WRN, prey = BLM xref: IntAct:EBI-706961 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0005358 ! WRN_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0008572 name: wrn-blm-7 direct interaction comment: Pull-down : bait = WRN, prey = BLM xref: IntAct:EBI-706971 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0005358 ! WRN_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0008573 name: wrn-blm-9 direct interaction comment: Pull-down : bait = WRN, prey = BLM xref: IntAct:EBI-706989 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0005358 ! WRN_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0008574 name: wrn-blm-2 colocalization comment: Colocalization of WRN and BLM in human Hela cells xref: IntAct:EBI-706884 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0005358 ! WRN_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0008575 name: wrn-blm-5 physical interaction comment: In vivo Co-IP: bait = BLM, prey = WRN xref: IntAct:EBI-706943 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005358 ! WRN_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0008576 name: menin-myh9-4 direct interaction comment: Interaction between human Menin and MYH9 detected by pulldown xref: IntAct:EBI-1140373 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0019193 ! MYH9_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:I0008577 name: myh9-menin-1 direct interaction comment: Interaction between human MYH9 and Menin detected by pulldown xref: IntAct:EBI-1141531 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0019193 ! MYH9_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:I0008578 name: wrn-blm-3 colocalization comment: Colocalization of WRN and BLM in WS cells xref: IntAct:EBI-706923 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0005358 ! WRN_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0008579 name: menin-myh9-3 physical interaction comment: Interaction between human Menin and MYH9 detected by coIP xref: IntAct:EBI-1139313 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0019193 ! MYH9_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:I0008580 name: blm-fen1-1 direct interaction comment: MBP pull-down: bait = BLM, prey = FEN-1 xref: IntAct:EBI-707913 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0039756 ! FEN1_HUMAN [Term] id: CCO:I0008581 name: menin-myh9-2 physical interaction comment: Interaction between human Menin and MYH9 detected by tandem affinity purification xref: IntAct:EBI-1137776 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0019193 ! MYH9_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:I0008582 name: menin-myh9-5 colocalization comment: Colocalisation of human Menin and MYH9 detected by immunofluorescence microscopy xref: IntAct:EBI-1144664 is_a: CCO:Y0000027 ! colocalization relationship: has_participant CCO:B0019193 ! MYH9_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:I0008583 name: blm-fen1-3 direct interaction comment: ELISA: bait = BLM, probe = FEN-1 xref: IntAct:EBI-708251 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: has_participant CCO:B0039756 ! FEN1_HUMAN [Term] id: CCO:I0008584 name: wrn-blm-1 direct interaction comment: ELISA: bait= WRN, probe=BLM xref: IntAct:EBI-706864 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0005358 ! WRN_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:I0008654 name: ppp1r16a-fsd1 physical interaction xref: IntAct:EBI-735429 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0039949 ! FSD1_HUMAN relationship: has_participant CCO:B0039979 ! PP16A_HUMAN [Term] id: CCO:I0008655 name: nap1l1-fsd1 physical interaction xref: IntAct:EBI-737219 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005376 ! NP1L1_HUMAN relationship: has_participant CCO:B0039949 ! FSD1_HUMAN [Term] id: CCO:I0008675 name: cinp-cluap1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-752512 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041266 ! CINP_HUMAN relationship: has_participant CCO:B0043416 ! CLUA1_HUMAN [Term] id: CCO:I0008676 name: trim39-ube2d1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753517 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0019462 ! UB2D1_HUMAN relationship: has_participant CCO:B0043417 ! TRI39_HUMAN [Term] id: CCO:I0008677 name: psmc4-psmc5 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753730 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041247 ! PRS6B_HUMAN relationship: has_participant CCO:B0041253 ! PRS8_HUMAN [Term] id: CCO:I0008678 name: ndp52-psma1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-753919 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0026268 ! CACO2_HUMAN [Term] id: CCO:I0008679 name: psme3-zcchc10 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754147 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006253 ! ZCH10_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008680 name: psma1-tsc22d4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-754642 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005176 ! T22D4_HUMAN relationship: has_participant CCO:B0005233 ! PSA1_HUMAN [Term] id: CCO:I0008681 name: nmi-psma1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755515 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0005695 ! NMI_HUMAN [Term] id: CCO:I0008682 name: rnf126-ube2d1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-755836 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0019462 ! UB2D1_HUMAN relationship: has_participant CCO:B0043418 ! RN126_HUMAN [Term] id: CCO:I0008683 name: bbs2-psme3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756448 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0043419 ! BBS2_HUMAN [Term] id: CCO:I0008684 name: psme3-serf2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756451 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0043420 ! SERF2_HUMAN [Term] id: CCO:I0008685 name: psmc5-rora physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-756745 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0019067 ! RORA_HUMAN relationship: has_participant CCO:B0041253 ! PRS8_HUMAN [Term] id: CCO:I0008686 name: psma1-vim physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757441 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0005737 ! VIME_HUMAN [Term] id: CCO:I0008687 name: psmc5-tnnt1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757474 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041253 ! PRS8_HUMAN relationship: has_participant CCO:B0043421 ! TNNT1_HUMAN [Term] id: CCO:I0008688 name: psme3-psme3-1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-757516 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008689 name: flj38984-psmc6 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758299 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030905 ! PRS10_HUMAN relationship: has_participant CCO:B0043422 ! CA216_HUMAN [Term] id: CCO:I0008690 name: c12orf2-psmd4 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758686 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041250 ! PSMD4_HUMAN relationship: has_participant CCO:B0043423 ! RASF8_HUMAN [Term] id: CCO:I0008691 name: psmc6-psmd9 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-758857 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030905 ! PRS10_HUMAN relationship: has_participant CCO:B0041239 ! PSMD9_HUMAN [Term] id: CCO:I0008692 name: kctd17-psma1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759031 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0043424 ! KCD17_HUMAN [Term] id: CCO:I0008693 name: itpkb-psme3 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759256 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0043425 ! IP3KB_HUMAN [Term] id: CCO:I0008694 name: krt15-psma1 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759544 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005207 ! K1C15_HUMAN relationship: has_participant CCO:B0005233 ! PSA1_HUMAN [Term] id: CCO:I0008695 name: btrc-trim9 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-759775 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005633 ! FBW1A_HUMAN relationship: has_participant CCO:B0043426 ! TRIM9_HUMAN [Term] id: CCO:I0008696 name: krt15-psmc5 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760000 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005207 ! K1C15_HUMAN relationship: has_participant CCO:B0041253 ! PRS8_HUMAN [Term] id: CCO:I0008697 name: psmc2-psmd5 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760210 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041246 ! PRS7_HUMAN relationship: has_participant CCO:B0041255 ! PSMD5_HUMAN [Term] id: CCO:I0008698 name: psme1-psme2 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760252 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006215 ! PSME1_HUMAN relationship: has_participant CCO:B0043427 ! PSME2_HUMAN [Term] id: CCO:I0008699 name: psmc4-psmd10 physical interaction comment: Part of the CCSB-H11 dataset. xref: IntAct:EBI-760255 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041240 ! PSD10_HUMAN relationship: has_participant CCO:B0041247 ! PRS6B_HUMAN [Term] id: CCO:I0008700 name: ncoa3-psme3-2 physical interaction comment: Interaction detected by CoIP. xref: IntAct:EBI-849865 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:I0008701 name: a2bp1-psmf1 physical interaction xref: IntAct:EBI-946332 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0032832 ! FOX1_HUMAN relationship: has_participant CCO:B0041263 ! PSMF1_HUMAN [Term] id: CCO:I0008702 name: ncoa3-psme3 physical interaction comment: Interaction detected by CoIP. xref: IntAct:EBI-849837 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:I0008703 name: nfkbie-psma5 physical interaction xref: IntAct:EBI-361059 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005538 ! IKBE_HUMAN relationship: has_participant CCO:B0022204 ! PSA5_HUMAN [Term] id: CCO:I0008704 name: nfkbie-psme3 physical interaction xref: IntAct:EBI-361152 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005538 ! IKBE_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008705 name: traf6-psmb6 physical interaction xref: IntAct:EBI-365107 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0031015 ! PSB6_HUMAN [Term] id: CCO:I0008706 name: traf6-psma4 physical interaction xref: IntAct:EBI-365143 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN [Term] id: CCO:I0008707 name: traf6-psmc6 physical interaction xref: IntAct:EBI-365149 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0030905 ! PRS10_HUMAN [Term] id: CCO:I0008708 name: traf6-psmd4 physical interaction xref: IntAct:EBI-365152 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0041250 ! PSMD4_HUMAN [Term] id: CCO:I0008709 name: traf6-psmc5 physical interaction xref: IntAct:EBI-365158 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0041253 ! PRS8_HUMAN [Term] id: CCO:I0008710 name: traf6-psmb2 physical interaction xref: IntAct:EBI-365161 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0030800 ! PSB2_HUMAN [Term] id: CCO:I0008711 name: traf6-psma1 physical interaction xref: IntAct:EBI-365212 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN [Term] id: CCO:I0008712 name: traf6-psmd6 physical interaction xref: IntAct:EBI-365476 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0032651 ! PSMD6_HUMAN [Term] id: CCO:I0008713 name: traf6-psmb5 physical interaction xref: IntAct:EBI-365479 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0030806 ! PSB5_HUMAN [Term] id: CCO:I0008714 name: traf6-psmc1 physical interaction xref: IntAct:EBI-365482 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005314 ! PRS4_HUMAN relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN [Term] id: CCO:I0008715 name: traf6-psmc2 physical interaction xref: IntAct:EBI-365485 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0041246 ! PRS7_HUMAN [Term] id: CCO:I0008716 name: traf6-psmc3 physical interaction xref: IntAct:EBI-365488 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0041242 ! PRS6A_HUMAN [Term] id: CCO:I0008717 name: traf6-psmd12 physical interaction xref: IntAct:EBI-365494 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0038144 ! PSD12_HUMAN [Term] id: CCO:I0008718 name: traf6-psmd3 physical interaction xref: IntAct:EBI-365500 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0021560 ! PSMD3_HUMAN [Term] id: CCO:I0008719 name: traf6-psmd7 physical interaction xref: IntAct:EBI-365503 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005536 ! TRAF6_HUMAN relationship: has_participant CCO:B0031003 ! PSD7_HUMAN [Term] id: CCO:I0008720 name: btrc-ctnnb1-1 physical interaction comment: Structure of a beta-trcp1-skp1-beta-catenin complex: destruction motif binding and lysine specificity on the scfbeta-trcp1 ubiquitin ligase xref: IntAct:EBI-1036687 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005327 ! CTNB1_HUMAN relationship: has_participant CCO:B0005633 ! FBW1A_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN [Term] id: CCO:I0008721 name: lsm1-psmb8 physical interaction xref: IntAct:EBI-373848 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006005 ! LSM1_HUMAN relationship: has_participant CCO:B0030804 ! PSB8_HUMAN [Term] id: CCO:I0008722 name: lsm1-psmb5 physical interaction xref: IntAct:EBI-373854 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006005 ! LSM1_HUMAN relationship: has_participant CCO:B0030806 ! PSB5_HUMAN [Term] id: CCO:I0008723 name: xrn2-psma3 physical interaction xref: IntAct:EBI-374109 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0043429 ! XRN2_HUMAN [Term] id: CCO:I0008724 name: alpha1-alpha2 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 1 and alpha 2 xref: IntAct:EBI-696759 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0041243 ! PSA2_HUMAN [Term] id: CCO:I0008725 name: alpha1-alpha7 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 1 and alpha 7 xref: IntAct:EBI-696762 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0030768 ! PSA7_HUMAN [Term] id: CCO:I0008726 name: alpha1-beta2 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 1 and beta 2 xref: IntAct:EBI-696766 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0030800 ! PSB2_HUMAN [Term] id: CCO:I0008727 name: alpha1-beta2i physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 1 and beta 2i xref: IntAct:EBI-696771 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0006219 ! PSB10_HUMAN [Term] id: CCO:I0008728 name: alpha2-alpha1 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 2 and alpha 1 xref: IntAct:EBI-696776 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0041243 ! PSA2_HUMAN [Term] id: CCO:I0008729 name: alpha2-alpha4 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 2 and alpha 4 xref: IntAct:EBI-696779 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041243 ! PSA2_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN [Term] id: CCO:I0008730 name: alpha3-alpha4 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 3 and alpha 4 xref: IntAct:EBI-696817 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN [Term] id: CCO:I0008731 name: alpha3-alpha2 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 3 and alpha 2 xref: IntAct:EBI-696822 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0041243 ! PSA2_HUMAN [Term] id: CCO:I0008732 name: alpha4-alpha3 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 4 and alpha 3 xref: IntAct:EBI-696826 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN [Term] id: CCO:I0008733 name: alpha4-alpha2 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 4 and alpha 2 xref: IntAct:EBI-696830 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041243 ! PSA2_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN [Term] id: CCO:I0008734 name: alpha4-alpha7 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 4 and alpha 7 xref: IntAct:EBI-696834 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030768 ! PSA7_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN [Term] id: CCO:I0008735 name: alpha6-alpha2 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 6 and alpha 2 xref: IntAct:EBI-696838 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041243 ! PSA2_HUMAN relationship: has_participant CCO:B0041251 ! PSA6_HUMAN [Term] id: CCO:I0008736 name: alpha6-alpha7 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 6 and alpha 7 xref: IntAct:EBI-696842 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030768 ! PSA7_HUMAN relationship: has_participant CCO:B0041251 ! PSA6_HUMAN [Term] id: CCO:I0008737 name: alpha7-alpha1 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 7 and alpha 1 xref: IntAct:EBI-696846 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0030768 ! PSA7_HUMAN [Term] id: CCO:I0008738 name: alpha7-alpha4 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 7 and alpha 4 xref: IntAct:EBI-696850 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030768 ! PSA7_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN [Term] id: CCO:I0008739 name: alpha7-alpha6 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits alpha 7 and alpha 6 xref: IntAct:EBI-696854 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030768 ! PSA7_HUMAN relationship: has_participant CCO:B0041251 ! PSA6_HUMAN [Term] id: CCO:I0008740 name: beta2-beta3 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 2 and beta 3 xref: IntAct:EBI-696858 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030800 ! PSB2_HUMAN relationship: has_participant CCO:B0030929 ! PSB3_HUMAN [Term] id: CCO:I0008741 name: beta1-beta3 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 1 and beta 3 xref: IntAct:EBI-696862 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030929 ! PSB3_HUMAN relationship: has_participant CCO:B0030961 ! PSB1_HUMAN [Term] id: CCO:I0008742 name: beta1-beta7 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 1 and beta 7 xref: IntAct:EBI-696866 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030961 ! PSB1_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:I0008743 name: beta1-beta5 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 1 and beta 5 xref: IntAct:EBI-696870 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030806 ! PSB5_HUMAN relationship: has_participant CCO:B0030961 ! PSB1_HUMAN [Term] id: CCO:I0008744 name: beta1-beta5i physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 1 and beta 5i xref: IntAct:EBI-696891 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030810 ! Q5JNW7_HUMAN relationship: has_participant CCO:B0030961 ! PSB1_HUMAN [Term] id: CCO:I0008745 name: beta1i-beta7 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 1i and beta 7 xref: IntAct:EBI-696904 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0031007 ! PSB9_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:I0008746 name: beta1i-beta5i physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 1i and beta 5i xref: IntAct:EBI-696909 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030810 ! Q5JNW7_HUMAN relationship: has_participant CCO:B0031007 ! PSB9_HUMAN [Term] id: CCO:I0008747 name: beta2i-beta3 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 2i and beta 3 xref: IntAct:EBI-696917 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006219 ! PSB10_HUMAN relationship: has_participant CCO:B0030929 ! PSB3_HUMAN [Term] id: CCO:I0008748 name: beta3-beta2i physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 3 and beta 2i xref: IntAct:EBI-696922 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006219 ! PSB10_HUMAN relationship: has_participant CCO:B0030929 ! PSB3_HUMAN [Term] id: CCO:I0008749 name: beta3-beta2 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 3 and beta 2 xref: IntAct:EBI-696925 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030800 ! PSB2_HUMAN relationship: has_participant CCO:B0030929 ! PSB3_HUMAN [Term] id: CCO:I0008750 name: beta5-beta1 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 5 and beta 1 xref: IntAct:EBI-696929 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030806 ! PSB5_HUMAN relationship: has_participant CCO:B0030961 ! PSB1_HUMAN [Term] id: CCO:I0008751 name: beta5-beta2 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 5 and beta 2 xref: IntAct:EBI-696932 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030800 ! PSB2_HUMAN relationship: has_participant CCO:B0030806 ! PSB5_HUMAN [Term] id: CCO:I0008752 name: beta5-beta3 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 5 and beta 3 xref: IntAct:EBI-696936 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030806 ! PSB5_HUMAN relationship: has_participant CCO:B0030929 ! PSB3_HUMAN [Term] id: CCO:I0008753 name: beta5-alpha3 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 5 and alpha 3 xref: IntAct:EBI-696940 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0030806 ! PSB5_HUMAN [Term] id: CCO:I0008754 name: beta5-beta7 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 5 and beta 7 xref: IntAct:EBI-696944 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030806 ! PSB5_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:I0008755 name: beta5i-beta7 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 5i and beta 7 xref: IntAct:EBI-696954 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030810 ! Q5JNW7_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:I0008756 name: beta6-beta7 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 6 and beta 7 xref: IntAct:EBI-696958 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0031015 ! PSB6_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:I0008757 name: beta7-beta3 physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 7 and beta 3 xref: IntAct:EBI-696967 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030929 ! PSB3_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:I0008758 name: beta7-beta7 physical interaction comment: Directed yeast 2 hybrid analysis reveals homotypic interaction of the proteasome subunit beta 7 xref: IntAct:EBI-696972 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:I0008759 name: beta7-beta5i physical interaction comment: Directed yeast 2 hybrid analysis reveals interaction between the proteasome subunits beta 7 and beta 5i xref: IntAct:EBI-696976 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0030810 ! Q5JNW7_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:I0008760 name: dtnbp1-psme3 physical interaction xref: IntAct:EBI-1106252 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005258 ! DTBP1_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008761 name: psma1-coil physical interaction xref: IntAct:EBI-955774 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0005621 ! P80C_HUMAN [Term] id: CCO:I0008762 name: psme3-coil physical interaction xref: IntAct:EBI-955782 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005621 ! P80C_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008763 name: psmc5-rora-1 physical interaction xref: IntAct:EBI-956038 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0019067 ! RORA_HUMAN relationship: has_participant CCO:B0041253 ! PRS8_HUMAN [Term] id: CCO:I0008764 name: atn1-psme3-2 physical interaction xref: IntAct:EBI-956430 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005944 ! ATN1_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008765 name: coil-psme3-1 physical interaction xref: IntAct:EBI-956646 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005621 ! P80C_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008766 name: psmf1-a2bp1 physical interaction xref: IntAct:EBI-956846 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0032832 ! FOX1_HUMAN relationship: has_participant CCO:B0041263 ! PSMF1_HUMAN [Term] id: CCO:I0008767 name: hrmt1l2-hmga2 physical interaction xref: IntAct:EBI-912570 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005713 ! ANM1_HUMAN relationship: has_participant CCO:B0041249 ! HMGA2_HUMAN [Term] id: CCO:I0008768 name: hrmt1l6-hmg2a physical interaction xref: IntAct:EBI-912646 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0036272 ! ANM6_HUMAN relationship: has_participant CCO:B0041249 ! HMGA2_HUMAN [Term] id: CCO:I0008769 name: ncoa3-psme3-1 physical interaction comment: Interaction detected by CoIP. xref: IntAct:EBI-849846 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:I0008770 name: hrmt1l6-hmga2 physical interaction xref: IntAct:EBI-912523 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0036272 ! ANM6_HUMAN relationship: has_participant CCO:B0041249 ! HMGA2_HUMAN [Term] id: CCO:I0008771 name: hsrma1-ube2e1 physical interaction xref: IntAct:EBI-348691 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041248 ! UB2E1_HUMAN relationship: has_participant CCO:B0043430 ! RNF5_HUMAN [Term] id: CCO:I0008772 name: bat2-psma3 physical interaction xref: IntAct:EBI-348883 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005898 ! BAT2_HUMAN relationship: has_participant CCO:B0005991 ! PSA3_HUMAN [Term] id: CCO:I0008773 name: 20s proteasome-1 physical interaction comment: The 20S proteasome complex of human erythrocyte cells xref: IntAct:EBI-603379 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0022204 ! PSA5_HUMAN relationship: has_participant CCO:B0030800 ! PSB2_HUMAN relationship: has_participant CCO:B0030806 ! PSB5_HUMAN relationship: has_participant CCO:B0030929 ! PSB3_HUMAN relationship: has_participant CCO:B0030961 ! PSB1_HUMAN relationship: has_participant CCO:B0031015 ! PSB6_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN relationship: has_participant CCO:B0041243 ! PSA2_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN relationship: has_participant CCO:B0041245 ! PSB4_HUMAN relationship: has_participant CCO:B0041251 ! PSA6_HUMAN [Term] id: CCO:I0008774 name: fbxl7-skp1 physical interaction xref: IntAct:EBI-914675 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0043431 ! FBXL7_HUMAN [Term] id: CCO:I0008775 name: fbxl2-skp1 physical interaction xref: IntAct:EBI-914753 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0043432 ! FBXW2_HUMAN [Term] id: CCO:I0008776 name: fbw5-skp1 physical interaction xref: IntAct:EBI-914761 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0043433 ! FBXW5_HUMAN [Term] id: CCO:I0008777 name: fbw6-skp1 physical interaction xref: IntAct:EBI-914791 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0043434 ! FBXW8_HUMAN [Term] id: CCO:I0008778 name: fbw7-skp1 physical interaction xref: IntAct:EBI-914799 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0005654 ! FBXW7_HUMAN [Term] id: CCO:I0008779 name: fbxo41-skp1 physical interaction xref: IntAct:EBI-914816 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0043435 ! FBX41_HUMAN [Term] id: CCO:I0008780 name: fbox11-skp1 physical interaction xref: IntAct:EBI-914839 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0006051 ! JHD1A_HUMAN [Term] id: CCO:I0008781 name: atn1-psme3 physical interaction xref: IntAct:EBI-950920 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005944 ! ATN1_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008782 name: atn1-psma3 physical interaction xref: IntAct:EBI-951046 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005944 ! ATN1_HUMAN relationship: has_participant CCO:B0005991 ! PSA3_HUMAN [Term] id: CCO:I0008783 name: atn1-psme3-1 physical interaction xref: IntAct:EBI-951052 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005944 ! ATN1_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008784 name: atn1-psma3-1 physical interaction xref: IntAct:EBI-951184 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005944 ! ATN1_HUMAN relationship: has_participant CCO:B0005991 ! PSA3_HUMAN [Term] id: CCO:I0008785 name: atxn1-psmc3 physical interaction xref: IntAct:EBI-952324 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005425 ! ATX1_HUMAN relationship: has_participant CCO:B0041242 ! PRS6A_HUMAN [Term] id: CCO:I0008786 name: coil-psme3 physical interaction xref: IntAct:EBI-952636 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005621 ! P80C_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008787 name: prnp-psma3 physical interaction xref: IntAct:EBI-953386 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0043436 ! PRIO_HUMAN [Term] id: CCO:I0008788 name: rere-psma3 physical interaction xref: IntAct:EBI-953422 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0043437 ! RERE_HUMAN [Term] id: CCO:I0008789 name: rere-psma3-1 physical interaction xref: IntAct:EBI-953476 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0043437 ! RERE_HUMAN [Term] id: CCO:I0008790 name: ncoa3-psme3-3 direct interaction comment: Interaction detected by GST-pulldown. xref: IntAct:EBI-849878 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:I0008791 name: ncoa3-psme3-4 direct interaction comment: Interaction detected by GST pull down. xref: IntAct:EBI-849908 is_a: CCO:Y0000028 ! direct interaction relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0043428 ! NCOA3_HUMAN [Term] id: CCO:I0008792 name: psma3-psma6-1 physical interaction comment: Interaction detected by His pull down. xref: IntAct:EBI-710424 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0041251 ! PSA6_HUMAN [Term] id: CCO:I0008793 name: 20s proteasome physical interaction comment: The 20S proteasome complex of human U937 cells xref: IntAct:EBI-603360 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006219 ! PSB10_HUMAN relationship: has_participant CCO:B0022204 ! PSA5_HUMAN relationship: has_participant CCO:B0030800 ! PSB2_HUMAN relationship: has_participant CCO:B0030929 ! PSB3_HUMAN relationship: has_participant CCO:B0030961 ! PSB1_HUMAN relationship: has_participant CCO:B0031015 ! PSB6_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN relationship: has_participant CCO:B0041243 ! PSA2_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN relationship: has_participant CCO:B0041245 ! PSB4_HUMAN relationship: has_participant CCO:B0041251 ! PSA6_HUMAN [Term] id: CCO:I0008794 name: itgb3bp-psme1 physical interaction xref: IntAct:EBI-728997 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006198 ! CENPR_HUMAN relationship: has_participant CCO:B0006215 ! PSME1_HUMAN [Term] id: CCO:I0008795 name: psma6-psma3 physical interaction xref: IntAct:EBI-729150 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0041251 ! PSA6_HUMAN [Term] id: CCO:I0008796 name: psme1-chd3 physical interaction xref: IntAct:EBI-730627 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006082 ! CHD3_HUMAN relationship: has_participant CCO:B0006215 ! PSME1_HUMAN [Term] id: CCO:I0008797 name: snrpf-psma3 physical interaction xref: IntAct:EBI-730864 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0043438 ! RUXF_HUMAN [Term] id: CCO:I0008798 name: psme1-psme1 physical interaction xref: IntAct:EBI-732992 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006215 ! PSME1_HUMAN [Term] id: CCO:I0008799 name: psme1-vcl physical interaction xref: IntAct:EBI-732995 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006215 ! PSME1_HUMAN relationship: has_participant CCO:B0043439 ! VINC_HUMAN [Term] id: CCO:I0008800 name: psme1-vim physical interaction xref: IntAct:EBI-732998 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005737 ! VIME_HUMAN relationship: has_participant CCO:B0006215 ! PSME1_HUMAN [Term] id: CCO:I0008801 name: psme3-hspa5 physical interaction xref: IntAct:EBI-733001 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005843 ! GRP78_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008802 name: snrpb-psma3 physical interaction xref: IntAct:EBI-733352 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0043440 ! RSMB_HUMAN [Term] id: CCO:I0008803 name: stx11-psma3 physical interaction xref: IntAct:EBI-733403 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005220 ! STX11_HUMAN relationship: has_participant CCO:B0005991 ! PSA3_HUMAN [Term] id: CCO:I0008804 name: ezh2-psmb6 physical interaction xref: IntAct:EBI-734460 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0031015 ! PSB6_HUMAN relationship: has_participant CCO:B0043441 ! EZH2_HUMAN [Term] id: CCO:I0008805 name: fbxo34-skp1a physical interaction xref: IntAct:EBI-734487 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0043442 ! FBX34_HUMAN [Term] id: CCO:I0008806 name: skp1a-fbxo34 physical interaction xref: IntAct:EBI-734490 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0043442 ! FBX34_HUMAN [Term] id: CCO:I0008807 name: psmd14-plekhb2 physical interaction xref: IntAct:EBI-735480 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005569 ! PKHB2_HUMAN relationship: has_participant CCO:B0023606 ! PSDE_HUMAN [Term] id: CCO:I0008808 name: psme3-atp5b physical interaction xref: IntAct:EBI-735483 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005827 ! ATPB_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008809 name: psme3-centa1 physical interaction xref: IntAct:EBI-735486 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0043443 ! CENA1_HUMAN [Term] id: CCO:I0008810 name: psme3-psme3 physical interaction xref: IntAct:EBI-735489 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041252 ! PSME3_HUMAN [Term] id: CCO:I0008811 name: stx11-psmc3 physical interaction xref: IntAct:EBI-735923 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005220 ! STX11_HUMAN relationship: has_participant CCO:B0041242 ! PRS6A_HUMAN [Term] id: CCO:I0008812 name: ube2e1-cbwd3 physical interaction xref: IntAct:EBI-736139 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041248 ! UB2E1_HUMAN relationship: has_participant CCO:B0043444 ! CBWD3_HUMAN [Term] id: CCO:I0008813 name: ube2e1-paep physical interaction xref: IntAct:EBI-736142 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006212 ! PAEP_HUMAN relationship: has_participant CCO:B0041248 ! UB2E1_HUMAN [Term] id: CCO:I0008814 name: usp22-hexa physical interaction xref: IntAct:EBI-736172 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0024005 ! UBP22_HUMAN relationship: has_participant CCO:B0043445 ! HEXA_HUMAN [Term] id: CCO:I0008815 name: usp22-mrpl10 physical interaction xref: IntAct:EBI-736175 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0024005 ! UBP22_HUMAN relationship: has_participant CCO:B0043446 ! RM10_HUMAN [Term] id: CCO:I0008816 name: usp22-psme1 physical interaction xref: IntAct:EBI-736178 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006215 ! PSME1_HUMAN relationship: has_participant CCO:B0024005 ! UBP22_HUMAN [Term] id: CCO:I0008817 name: usp22-scfd1 physical interaction xref: IntAct:EBI-736181 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006349 ! SCFD1_HUMAN relationship: has_participant CCO:B0024005 ! UBP22_HUMAN [Term] id: CCO:I0008818 name: c2f-psmb7 physical interaction xref: IntAct:EBI-736397 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006260 ! NEP1_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN [Term] id: CCO:I0008819 name: c2f-psme1 physical interaction xref: IntAct:EBI-736400 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006215 ! PSME1_HUMAN relationship: has_participant CCO:B0006260 ! NEP1_HUMAN [Term] id: CCO:I0008820 name: ddx19b-skp1a physical interaction xref: IntAct:EBI-736565 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0043447 ! DD19B_HUMAN [Term] id: CCO:I0008821 name: mrps9-ccndbp1 physical interaction xref: IntAct:EBI-737207 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0041241 ! CCDB1_HUMAN relationship: has_participant CCO:B0043448 ! RT09_HUMAN [Term] id: CCO:I0008822 name: psmd14-flj10324 physical interaction xref: IntAct:EBI-737462 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0023606 ! PSDE_HUMAN relationship: has_participant CCO:B0043449 ! Q75LH2_HUMAN [Term] id: CCO:I0008823 name: psmd14-rbm15b physical interaction xref: IntAct:EBI-737465 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0023606 ! PSDE_HUMAN relationship: has_participant CCO:B0043450 ! RB15B_HUMAN [Term] id: CCO:I0008824 name: rab1a-psmd7 physical interaction xref: IntAct:EBI-737483 is_a: CCO:Y0000060 ! physical association relationship: has_participant CCO:B0006222 ! RAB1A_HUMAN relationship: has_participant CCO:B0031003 ! PSD7_HUMAN [Term] id: CCO:P0000001 name: mitotic spindle elongation namespace: biological_process def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah] synonym: "spindle elongation during mitosis" EXACT [] xref: GO:0000022 is_a: CCO:P0000293 ! spindle elongation relationship: has_participant CCO:B0001394 ! PRC1_HUMAN relationship: has_participant CCO:B0001716 ! KIF23_HUMAN relationship: part_of CCO:P0000068 ! mitotic spindle organization and biogenesis [Term] id: CCO:P0000002 name: mitotic sister chromatid segregation namespace: biological_process def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai] synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] xref: GO:0000070 xref: GO:0016359 is_a: CCO:P0000054 ! sister chromatid segregation relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN relationship: has_participant CCO:B0001787 ! ESPL1_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0002037 ! DDX11_HUMAN relationship: has_participant CCO:B0002105 ! KIFC1_HUMAN relationship: has_participant CCO:B0002108 ! NUSAP_HUMAN relationship: has_participant CCO:B0002168 ! SMC4_HUMAN relationship: has_participant CCO:B0002208 ! KIF25_HUMAN relationship: part_of CCO:P0000081 ! mitosis [Term] id: CCO:P0000003 name: M phase specific microtubule process namespace: biological_process def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah] synonym: "M-phase specific microtubule process" EXACT [] xref: GO:0000072 is_a: CCO:U0000002 ! biological process relationship: has_participant CCO:B0001657 ! IMA2_HUMAN relationship: part_of CCO:P0000039 ! M phase [Term] id: CCO:P0000004 name: spindle pole body separation namespace: biological_process def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators] synonym: "spindle pole body separation (sensu Fungi)" EXACT [] synonym: "spindle pole body separation (sensu Saccharomyces)" NARROW [] xref: GO:0000073 xref: GO:0030475 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000302 ! spindle pole body organization and biogenesis [Term] id: CCO:P0000006 name: cell cycle checkpoint namespace: biological_process def: "A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, ISBN:0815316194] xref: GO:0000075 xref: Reactome:212094 xref: Reactome:221853 xref: Reactome:230421 xref: Reactome:238463 xref: Reactome:245004 xref: Reactome:249905 xref: Reactome:252621 xref: Reactome:255806 xref: Reactome:259199 xref: Reactome:262557 xref: Reactome:265381 xref: Reactome:268515 xref: Reactome:274237 xref: Reactome:280705 xref: Reactome:282912 xref: Reactome:286730 xref: Reactome:69620 is_a: CCO:P0000346 ! regulation of cell cycle relationship: has_participant CCO:B0001370 ! FANCG_HUMAN relationship: has_participant CCO:B0001413 ! RAD1_HUMAN relationship: has_participant CCO:B0001460 ! CCNE2_HUMAN relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0001714 ! XPC_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001821 ! CCNG2_HUMAN relationship: has_participant CCO:B0002084 ! RBBP8_HUMAN relationship: has_participant CCO:B0002178 ! MLTK_HUMAN relationship: has_participant CCO:B0005584 ! DDB1_HUMAN relationship: has_participant CCO:B0026248 ! ERCC2_HUMAN relationship: has_participant CCO:B0028502 ! ERCC3_HUMAN [Term] id: CCO:P0000007 name: DNA replication checkpoint namespace: biological_process def: "A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:rn, PMID:11728327, PMID:12537518] xref: GO:0000076 is_a: CCO:P0000183 ! DNA integrity checkpoint relationship: has_participant CCO:B0001426 ! CC45L_HUMAN relationship: has_participant CCO:B0001441 ! RAD17_HUMAN relationship: has_participant CCO:B0002077 ! RAD9A_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0002104 ! TIPIN_HUMAN relationship: has_participant CCO:B0002126 ! CDT1_HUMAN [Term] id: CCO:P0000008 name: DNA damage checkpoint namespace: biological_process def: "A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds." [PMID:11891124] synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW [] xref: GO:0000077 is_a: CCO:P0000183 ! DNA integrity checkpoint relationship: has_participant CCO:B0001347 ! FOXN3_HUMAN relationship: has_participant CCO:B0001359 ! CHK1_HUMAN relationship: has_participant CCO:B0001413 ! RAD1_HUMAN relationship: has_participant CCO:B0001419 ! HUS1_HUMAN relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001441 ! RAD17_HUMAN relationship: has_participant CCO:B0001459 ! CHK2_HUMAN relationship: has_participant CCO:B0001756 ! ATR_HUMAN relationship: has_participant CCO:B0002009 ! ATRIP_HUMAN relationship: has_participant CCO:B0002077 ! RAD9A_HUMAN relationship: has_participant CCO:B0002107 ! FANCJ_HUMAN relationship: has_participant CCO:B0002178 ! MLTK_HUMAN [Term] id: CCO:P0000009 name: cell morphogenesis checkpoint namespace: biological_process def: "A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective." [GOC:vw, PMID:14644188] xref: GO:0000078 is_a: CCO:P0000104 ! mitotic cell cycle checkpoint [Term] id: CCO:P0000010 name: regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators] synonym: "regulation of CDK activity" EXACT [] xref: GO:0000079 is_a: CCO:P0000346 ! regulation of cell cycle relationship: has_participant CCO:B0001359 ! CHK1_HUMAN relationship: has_participant CCO:B0001410 ! CCNT1_HUMAN relationship: has_participant CCO:B0001412 ! CCNT2_HUMAN relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0001453 ! DIRA3_HUMAN relationship: has_participant CCO:B0001460 ! CCNE2_HUMAN relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001552 ! GA45A_HUMAN relationship: has_participant CCO:B0001576 ! MPIP1_HUMAN relationship: has_participant CCO:B0001578 ! MPIP3_HUMAN relationship: has_participant CCO:B0001585 ! TF2H1_HUMAN relationship: has_participant CCO:B0001586 ! CKS2_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0001640 ! CDN1C_HUMAN relationship: has_participant CCO:B0001644 ! CDK7_HUMAN relationship: has_participant CCO:B0001652 ! CCNH_HUMAN relationship: has_participant CCO:B0001653 ! MAT1_HUMAN relationship: has_participant CCO:B0001656 ! CCNG1_HUMAN relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0001686 ! CKS1_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0001751 ! CD5R2_HUMAN relationship: has_participant CCO:B0001802 ! CD5R1_HUMAN relationship: has_participant CCO:B0001819 ! CDC37_HUMAN relationship: has_participant CCO:B0001823 ! CDKN3_HUMAN relationship: has_participant CCO:B0002044 ! CK5P3_HUMAN relationship: has_participant CCO:B0002078 ! PMYT1_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0002116 ! NOG1_HUMAN relationship: has_participant CCO:B0002137 ! RGC32_HUMAN relationship: has_participant CCO:B0002187 ! BCCIP_HUMAN relationship: has_participant CCO:B0002202 ! SRTD1_HUMAN relationship: has_participant CCO:B0002206 ! HERC5_HUMAN relationship: has_participant CCO:B0002216 ! ANC2_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:P0000011 name: G1 phase of mitotic cell cycle namespace: biological_process def: "Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis." [ISBN:0815316194] xref: GO:0000080 xref: Reactome:212033 xref: Reactome:221797 xref: Reactome:230372 xref: Reactome:238411 xref: Reactome:69236 is_a: CCO:P0000313 ! G1 phase relationship: has_participant CCO:B0001418 ! DNJA2_HUMAN relationship: has_participant CCO:B0001543 ! TAF1_HUMAN relationship: has_participant CCO:B0001640 ! CDN1C_HUMAN relationship: has_participant CCO:B0001706 ! FOXO4_HUMAN relationship: has_participant CCO:B0001713 ! E2F1_HUMAN relationship: has_participant CCO:B0001815 ! Q16164_HUMAN relationship: has_participant CCO:B0001820 ! M3K11_HUMAN relationship: has_participant CCO:B0002030 ! TBRG4_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0002216 ! ANC2_HUMAN relationship: part_of CCO:P0000324 ! interphase of mitotic cell cycle [Term] id: CCO:P0000012 name: G1/S transition of mitotic cell cycle namespace: biological_process def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GOC:mah] xref: GO:0000082 xref: Reactome:212021 xref: Reactome:221784 xref: Reactome:230362 xref: Reactome:238403 xref: Reactome:244953 xref: Reactome:249850 xref: Reactome:252607 xref: Reactome:255745 xref: Reactome:259140 xref: Reactome:262495 xref: Reactome:265325 xref: Reactome:268498 xref: Reactome:274174 xref: Reactome:280647 xref: Reactome:282899 xref: Reactome:286666 xref: Reactome:288375 xref: Reactome:289876 xref: Reactome:290408 xref: Reactome:291794 xref: Reactome:293774 xref: Reactome:69206 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0001353 ! PPP6_HUMAN relationship: has_participant CCO:B0001498 ! INHBA_HUMAN relationship: has_participant CCO:B0001520 ! ERF3A_HUMAN relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001597 ! ACV1B_HUMAN relationship: has_participant CCO:B0001628 ! UB2R1_HUMAN relationship: has_participant CCO:B0001671 ! BCAT1_HUMAN relationship: has_participant CCO:B0001720 ! ACVR1_HUMAN relationship: has_participant CCO:B0001724 ! DPOE1_HUMAN relationship: has_participant CCO:B0001749 ! SKP2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0001760 ! CUL2_HUMAN relationship: has_participant CCO:B0001761 ! CUL3_HUMAN relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0001823 ! CDKN3_HUMAN relationship: has_participant CCO:B0001862 ! SPDYA_HUMAN relationship: has_participant CCO:B0002027 ! CUL5_HUMAN relationship: has_participant CCO:B0002038 ! CDCA5_HUMAN relationship: has_participant CCO:B0002159 ! LATS2_HUMAN relationship: has_participant CCO:B0002194 ! DBF4A_HUMAN relationship: part_of CCO:P0000324 ! interphase of mitotic cell cycle [Term] id: CCO:P0000013 name: G1/S-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G1/S phase of the mitotic cell cycle." [GOC:mah] xref: GO:0000083 xref: Reactome:69205 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0002083 ! GFI1_HUMAN relationship: part_of CCO:P0000012 ! G1/S transition of mitotic cell cycle [Term] id: CCO:P0000014 name: S phase of mitotic cell cycle namespace: biological_process def: "Progression through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place." [ISBN:0815316194] xref: GO:0000084 is_a: CCO:P0000315 ! S phase relationship: has_participant CCO:B0001355 ! CDKA1_HUMAN relationship: has_participant CCO:B0001503 ! DPOLA_HUMAN relationship: has_participant CCO:B0001564 ! DPOD1_HUMAN relationship: has_participant CCO:B0002037 ! DDX11_HUMAN relationship: part_of CCO:P0000324 ! interphase of mitotic cell cycle [Term] id: CCO:P0000015 name: G2 phase of mitotic cell cycle namespace: biological_process def: "Progression through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis." [ISBN:0815316194] xref: GO:0000085 xref: Reactome:211891 xref: Reactome:221655 xref: Reactome:230246 xref: Reactome:238281 xref: Reactome:244852 xref: Reactome:249746 xref: Reactome:268392 xref: Reactome:274099 xref: Reactome:280573 xref: Reactome:68911 is_a: CCO:P0000314 ! G2 phase relationship: has_participant CCO:B0001347 ! FOXN3_HUMAN relationship: has_participant CCO:B0001629 ! CENPF_HUMAN relationship: has_participant CCO:B0001657 ! IMA2_HUMAN relationship: has_participant CCO:B0002180 ! GTSE1_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN relationship: part_of CCO:P0000324 ! interphase of mitotic cell cycle [Term] id: CCO:P0000016 name: G2/M transition of mitotic cell cycle namespace: biological_process def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mah] xref: GO:0000086 xref: Reactome:211972 xref: Reactome:221737 xref: Reactome:230316 xref: Reactome:238398 xref: Reactome:244912 xref: Reactome:249804 xref: Reactome:252543 xref: Reactome:255721 xref: Reactome:259114 xref: Reactome:262473 xref: Reactome:265322 xref: Reactome:268466 xref: Reactome:274171 xref: Reactome:280644 xref: Reactome:282855 xref: Reactome:286663 xref: Reactome:69275 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001377 ! BIRC5_HUMAN relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0001519 ! CCNB1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001643 ! DYN2_HUMAN relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0001825 ! TPD53_HUMAN relationship: has_participant CCO:B0002037 ! DDX11_HUMAN relationship: has_participant CCO:B0002214 ! APC5_HUMAN relationship: has_participant CCO:B0002215 ! APC4_HUMAN relationship: has_participant CCO:B0002230 ! APC10_HUMAN relationship: has_participant CCO:B0002265 ! USH1C_HUMAN relationship: part_of CCO:P0000324 ! interphase of mitotic cell cycle [Term] id: CCO:P0000017 name: M phase of mitotic cell cycle namespace: biological_process def: "Progression through M phase, the part of the mitotic cell cycle during which mitosis takes place." [GOC:mah, ISBN:0815316194] synonym: "M-phase of mitotic cell cycle" EXACT [] xref: GO:0000087 xref: Reactome:212043 xref: Reactome:221806 xref: Reactome:230379 xref: Reactome:238418 xref: Reactome:244995 xref: Reactome:249877 xref: Reactome:252596 xref: Reactome:255795 xref: Reactome:259176 xref: Reactome:262532 xref: Reactome:265359 xref: Reactome:268488 xref: Reactome:282892 xref: Reactome:286702 xref: Reactome:68886 is_a: CCO:P0000039 ! M phase relationship: has_participant CCO:B0001393 ! O43550_HUMAN relationship: has_participant CCO:B0001576 ! MPIP1_HUMAN relationship: has_participant CCO:B0001577 ! MPIP2_HUMAN relationship: has_participant CCO:B0001578 ! MPIP3_HUMAN relationship: has_participant CCO:B0001629 ! CENPF_HUMAN relationship: has_participant CCO:B0001807 ! DLG7_HUMAN relationship: has_participant CCO:B0002056 ! MPPH1_HUMAN relationship: has_participant CCO:B0002071 ! MPH6_HUMAN relationship: has_participant CCO:B0002127 ! Q9H2F0_HUMAN relationship: part_of CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000018 name: mitotic prophase namespace: biological_process def: "Progression through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle." [ISBN:0815316194] xref: GO:0000088 xref: Reactome:211977 xref: Reactome:221742 xref: Reactome:230322 xref: Reactome:238359 xref: Reactome:244917 xref: Reactome:249807 xref: Reactome:252546 xref: Reactome:255723 xref: Reactome:259116 xref: Reactome:262475 xref: Reactome:268434 xref: Reactome:286639 xref: Reactome:68875 is_a: CCO:P0000319 ! prophase relationship: part_of CCO:P0000081 ! mitosis [Term] id: CCO:P0000019 name: mitotic metaphase namespace: biological_process def: "Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles." [ISBN:0815316194] xref: GO:0000089 xref: Reactome:68879 is_a: CCO:P0000318 ! metaphase relationship: has_participant CCO:B0001715 ! CENPE_HUMAN relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: part_of CCO:P0000081 ! mitosis [Term] id: CCO:P0000020 name: mitotic anaphase namespace: biological_process def: "Progression through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [ISBN:0815316194] xref: GO:0000090 xref: Reactome:68882 is_a: CCO:P0000317 ! anaphase relationship: has_participant CCO:B0001794 ! NUMA1_HUMAN relationship: has_participant CCO:B0002214 ! APC5_HUMAN relationship: has_participant CCO:B0002215 ! APC4_HUMAN relationship: has_participant CCO:B0002230 ! APC10_HUMAN relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: part_of CCO:P0000081 ! mitosis [Term] id: CCO:P0000021 name: mitotic anaphase A namespace: biological_process def: "Progression through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [ISBN:0815316194] xref: GO:0000091 is_a: CCO:P0000020 ! mitotic anaphase [Term] id: CCO:P0000022 name: mitotic anaphase B namespace: biological_process def: "Progression through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [ISBN:0815316194] xref: GO:0000092 is_a: CCO:P0000020 ! mitotic anaphase [Term] id: CCO:P0000023 name: mitotic telophase namespace: biological_process def: "Progression through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: GO:0000093 is_a: CCO:P0000321 ! telophase relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: part_of CCO:P0000081 ! mitosis [Term] id: CCO:P0000024 name: G1-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G1 phase of the mitotic cell cycle." [GOC:mah] xref: GO:0000114 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001898 ! GFI1B_HUMAN relationship: part_of CCO:P0000011 ! G1 phase of mitotic cell cycle [Term] id: CCO:P0000025 name: S-phase-specific transcription in mitotic cell cycle namespace: biological_process def: "A cell cycle process that regulates transcription such that the target genes are transcribed during the S phase of the mitotic cell cycle." [GOC:mah] synonym: "S-specific transcription in mitotic cell cycle" EXACT [] xref: GO:0000115 xref: Reactome:69241 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001461 ! ABL1_HUMAN relationship: part_of CCO:P0000014 ! S phase of mitotic cell cycle [Term] id: CCO:P0000026 name: G2-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G2 phase of the mitotic cell cycle." [GOC:mah] xref: GO:0000116 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000015 ! G2 phase of mitotic cell cycle [Term] id: CCO:P0000027 name: G2/M-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G2/M phase of the mitotic cell cycle." [GOC:mah] xref: GO:0000117 xref: Reactome:69274 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000016 ! G2/M transition of mitotic cell cycle [Term] id: CCO:P0000028 name: establishment of mitotic spindle orientation namespace: biological_process def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] synonym: "establishment of spindle orientation during mitosis" EXACT [] synonym: "mitotic spindle orientation" EXACT [] synonym: "mitotic spindle orientation (sensu Fungi)" NARROW [] synonym: "mitotic spindle orientation (sensu Saccharomyces)" NARROW [] synonym: "orienting of mitotic spindle" EXACT [] xref: GO:0000132 xref: GO:0030607 xref: GO:0030609 is_a: CCO:P0000225 ! establishment of mitotic spindle localization relationship: has_participant CCO:B0001618 ! LIS1_HUMAN [Term] id: CCO:P0000029 name: septin checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642] xref: GO:0000135 is_a: CCO:P0000178 ! cytokinesis checkpoint [Term] id: CCO:P0000030 name: meiotic spindle organization and biogenesis namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] synonym: "meiotic spindle organisation and biogenesis" EXACT [] synonym: "spindle organization and biogenesis during meiosis" EXACT [] xref: GO:0000212 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001548 ! TBG1_HUMAN relationship: part_of CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000031 name: M/G1 transition of mitotic cell cycle namespace: biological_process def: "Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah] xref: GO:0000216 xref: Reactome:211997 xref: Reactome:221761 xref: Reactome:230342 xref: Reactome:238378 xref: Reactome:244933 xref: Reactome:249898 xref: Reactome:252623 xref: Reactome:255800 xref: Reactome:259165 xref: Reactome:262551 xref: Reactome:265375 xref: Reactome:274161 xref: Reactome:280634 xref: Reactome:286652 xref: Reactome:68874 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000324 ! interphase of mitotic cell cycle [Term] id: CCO:P0000032 name: mitotic prometaphase namespace: biological_process def: "Progression through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mah, ISBN:0198547684] xref: GO:0000236 xref: Reactome:68877 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000081 ! mitosis [Term] id: CCO:P0000033 name: leptotene namespace: biological_process def: "Progression through the first stage of prophase I in meiosis, in which chromosomes first become visible." [ISBN:0198547684] xref: GO:0000237 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000119 ! meiotic prophase I [Term] id: CCO:P0000034 name: zygotene namespace: biological_process def: "Progression through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [ISBN:0198547684] xref: GO:0000238 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000119 ! meiotic prophase I [Term] id: CCO:P0000035 name: pachytene namespace: biological_process def: "Progression through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [ISBN:0198547684] xref: GO:0000239 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000119 ! meiotic prophase I [Term] id: CCO:P0000036 name: diplotene namespace: biological_process def: "Progression through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [ISBN:0198547684] xref: GO:0000240 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000119 ! meiotic prophase I [Term] id: CCO:P0000037 name: diakinesis namespace: biological_process def: "Progression through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [ISBN:0198547684] xref: GO:0000241 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000119 ! meiotic prophase I [Term] id: CCO:P0000038 name: mitotic cell cycle namespace: biological_process def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] xref: GO:0000278 xref: Reactome:212083 xref: Reactome:221841 xref: Reactome:230408 xref: Reactome:238450 xref: Reactome:244991 xref: Reactome:249871 xref: Reactome:252608 xref: Reactome:255794 xref: Reactome:259188 xref: Reactome:262544 xref: Reactome:265374 xref: Reactome:268486 xref: Reactome:274210 xref: Reactome:280680 xref: Reactome:282900 xref: Reactome:286715 xref: Reactome:288392 xref: Reactome:289890 xref: Reactome:290421 xref: Reactome:291802 xref: Reactome:293782 xref: Reactome:69278 is_a: CCO:P0000066 ! cell cycle relationship: has_participant CCO:B0001577 ! MPIP2_HUMAN relationship: has_participant CCO:B0001629 ! CENPF_HUMAN relationship: has_participant CCO:B0001797 ! CND2_HUMAN relationship: has_participant CCO:B0002099 ! CP250_HUMAN [Term] id: CCO:P0000039 name: M phase namespace: biological_process def: "Progression through M phase, the part of the cell cycle comprising nuclear division." [ISBN:0815316194] synonym: "M-phase" EXACT [] xref: GO:0000279 is_a: CCO:P0000160 ! cell cycle phase relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001734 ! ILF3_HUMAN relationship: has_participant CCO:B0002068 ! Q99539_HUMAN relationship: has_participant CCO:B0002069 ! Q99540_HUMAN [Term] id: CCO:P0000040 name: cytokinesis after mitosis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai] xref: GO:0000281 is_a: CCO:P0000212 ! cytokinesis during cell cycle relationship: has_participant CCO:B0002108 ! NUSAP_HUMAN relationship: has_participant CCO:B0019194 ! MYH10_HUMAN [Term] id: CCO:P0000041 name: re-entry into mitotic cell cycle namespace: biological_process def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc] xref: GO:0000320 is_a: CCO:P0000159 ! cell cycle process [Term] id: CCO:P0000042 name: re-entry into mitotic cell cycle after pheromone arrest namespace: biological_process def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449] synonym: "re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)" NARROW [] xref: GO:0000321 is_a: CCO:P0000041 ! re-entry into mitotic cell cycle [Term] id: CCO:P0000043 name: achiasmate meiosis I namespace: biological_process def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419] xref: GO:0000705 is_a: CCO:P0000118 ! meiosis I [Term] id: CCO:P0000044 name: meiotic DNA double-strand break processing namespace: biological_process def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] xref: GO:0000706 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000063 ! meiotic gene conversion relationship: part_of CCO:P0000122 ! meiotic recombination [Term] id: CCO:P0000045 name: meiotic DNA recombinase assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983] xref: GO:0000707 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000063 ! meiotic gene conversion relationship: part_of CCO:P0000122 ! meiotic recombination [Term] id: CCO:P0000046 name: meiotic strand invasion namespace: biological_process def: "The cell cycle process whereby the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877] synonym: "meiotic D-loop biosynthesis" RELATED [] synonym: "meiotic D-loop formation" RELATED [] xref: GO:0000708 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000063 ! meiotic gene conversion relationship: part_of CCO:P0000122 ! meiotic recombination [Term] id: CCO:P0000047 name: meiotic joint molecule formation namespace: biological_process def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495] xref: GO:0000709 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000122 ! meiotic recombination [Term] id: CCO:P0000048 name: meiotic mismatch repair namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] xref: GO:0000710 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000063 ! meiotic gene conversion relationship: part_of CCO:P0000122 ! meiotic recombination [Term] id: CCO:P0000049 name: meiotic DNA repair synthesis namespace: biological_process def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324] xref: GO:0000711 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000063 ! meiotic gene conversion relationship: part_of CCO:P0000122 ! meiotic recombination [Term] id: CCO:P0000050 name: resolution of meiotic joint molecules as recombinants namespace: biological_process def: "The cleavage and rejoining of Holliday junctions formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053] synonym: "crossover biosynthesis" NARROW [] synonym: "crossover formation" NARROW [] synonym: "formation of chiasmata" NARROW [] synonym: "homologous chromosome separation at meiosis I" EXACT [] synonym: "meiotic homologous chromosome separation" RELATED [] xref: GO:0000712 is_a: CCO:P0000305 ! meiotic chromosome separation relationship: part_of CCO:P0000122 ! meiotic recombination relationship: part_of CCO:P0000239 ! homologous chromosome segregation [Term] id: CCO:P0000051 name: meiotic heteroduplex formation namespace: biological_process def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324] xref: GO:0000713 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000063 ! meiotic gene conversion [Term] id: CCO:P0000052 name: meiotic strand displacement namespace: biological_process def: "The cell cycle process whereby the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855] xref: GO:0000714 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000063 ! meiotic gene conversion [Term] id: CCO:P0000053 name: cell cycle arrest in response to pheromone namespace: biological_process def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus." [GOC:clt, GOC:dph, GOC:tb] synonym: "cell cycle arrest (sensu Saccharomyces)" RELATED [] xref: GO:0000751 xref: GO:0030571 is_a: CCO:P0000067 ! cell cycle arrest [Term] id: CCO:P0000054 name: sister chromatid segregation namespace: biological_process def: "The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] xref: GO:0000819 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001454 ! LATS1_HUMAN [Term] id: CCO:P0000055 name: cytokinesis by cell plate formation namespace: biological_process def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells." [GOC:clt] synonym: "cytokinesis (sensu Viridiplantae)" NARROW [] xref: GO:0000911 is_a: CCO:P0000212 ! cytokinesis during cell cycle [Term] id: CCO:P0000056 name: formation of actomyosin apparatus involved in cytokinesis namespace: biological_process def: "The formation of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt] synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb] xref: GO:0000912 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000212 ! cytokinesis during cell cycle [Term] id: CCO:P0000057 name: preprophase band formation namespace: biological_process def: "The process of marking the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt] xref: GO:0000913 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000055 ! cytokinesis by cell plate formation [Term] id: CCO:P0000058 name: phragmoplast formation namespace: biological_process def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt] xref: GO:0000914 is_a: CCO:P0000056 ! formation of actomyosin apparatus involved in cytokinesis relationship: part_of CCO:P0000055 ! cytokinesis by cell plate formation [Term] id: CCO:P0000059 name: cytokinesis, contractile ring formation namespace: biological_process def: "The process of formation of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt] synonym: "constriction ring assembly" NARROW [] synonym: "cytokinesis, actomyosin ring biosynthesis" EXACT [] synonym: "cytokinesis, actomyosin ring formation" EXACT [] synonym: "cytokinesis, contractile ring assembly" NARROW [] xref: GO:0000915 xref: GO:0045573 is_a: CCO:P0000056 ! formation of actomyosin apparatus involved in cytokinesis relationship: has_participant CCO:B0002124 ! RGAP1_HUMAN [Term] id: CCO:P0000060 name: contractile ring contraction involved in cytokinesis namespace: biological_process def: "The process of an actomyosin ring, which functions in cytokinesis, getting smaller in diameter." [GOC:clt, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin ring contraction" EXACT [] synonym: "cytokinesis, contractile ring contraction" EXACT [GOC:dph, GOC:tb] xref: GO:0000916 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000212 ! cytokinesis during cell cycle [Term] id: CCO:P0000061 name: cell plate formation namespace: biological_process def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt] xref: GO:0000919 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000055 ! cytokinesis by cell plate formation [Term] id: CCO:P0000062 name: negative regulation of exit from mitosis namespace: biological_process def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn] synonym: "down regulation of exit from mitosis" EXACT [] synonym: "down-regulation of exit from mitosis" EXACT [] synonym: "downregulation of exit from mitosis" EXACT [] synonym: "inhibition of exit from mitosis" NARROW [] xref: GO:0001100 is_a: CCO:P0000107 ! regulation of exit from mitosis is_a: CCO:P0000250 ! negative regulation of mitosis relationship: negatively_regulates CCO:P0000152 ! exit from mitosis [Term] id: CCO:P0000063 name: meiotic gene conversion namespace: biological_process def: "The cell cycle process whereby genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194] synonym: "gene conversion without reciprocal crossover" EXACT [] xref: GO:0006311 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000064 name: S-phase-specific histone modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026] xref: GO:0006324 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000315 ! S phase [Term] id: CCO:P0000065 name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators] xref: GO:0006977 is_a: CCO:U0000002 ! biological process relationship: has_participant CCO:B0001398 ! TRIA1_HUMAN relationship: has_participant CCO:B0001570 ! PML_HUMAN relationship: has_participant CCO:B0002064 ! GML_HUMAN relationship: has_participant CCO:B0002121 ! Q9GZT1_HUMAN relationship: has_participant CCO:B0002180 ! GTSE1_HUMAN relationship: has_participant CCO:B0017902 ! RBM38_HUMAN relationship: part_of CCO:P0000184 ! G1 DNA damage checkpoint [Term] id: CCO:P0000066 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "cell-division cycle" EXACT [] xref: GO:0007049 is_a: CCO:U0000002 ! biological process relationship: has_participant CCO:B0001317 ! E2F8_HUMAN relationship: has_participant CCO:B0001318 ! A4D1Y2_HUMAN relationship: has_participant CCO:B0001319 ! A6NC65_HUMAN relationship: has_participant CCO:B0001324 ! A6NFQ9_HUMAN relationship: has_participant CCO:B0001328 ! A6NHZ8_HUMAN relationship: has_participant CCO:B0001334 ! SAC31_HUMAN relationship: has_participant CCO:B0001335 ! A6NKP6_HUMAN relationship: has_participant CCO:B0001339 ! A6NMH6_HUMAN relationship: has_participant CCO:B0001345 ! SPT5H_HUMAN relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0001347 ! FOXN3_HUMAN relationship: has_participant CCO:B0001349 ! BIN1_HUMAN relationship: has_participant CCO:B0001350 ! LHR2A_HUMAN relationship: has_participant CCO:B0001352 ! E2F3_HUMAN relationship: has_participant CCO:B0001353 ! PPP6_HUMAN relationship: has_participant CCO:B0001354 ! UBE2C_HUMAN relationship: has_participant CCO:B0001355 ! CDKA1_HUMAN relationship: has_participant CCO:B0001356 ! CTRO_HUMAN relationship: has_participant CCO:B0001359 ! CHK1_HUMAN relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001363 ! STK6_HUMAN relationship: has_participant CCO:B0001364 ! GAK_HUMAN relationship: has_participant CCO:B0001367 ! AXN1_HUMAN relationship: has_participant CCO:B0001368 ! CETN3_HUMAN relationship: has_participant CCO:B0001369 ! MK13_HUMAN relationship: has_participant CCO:B0001372 ! PPM1D_HUMAN relationship: has_participant CCO:B0001374 ! P73_HUMAN relationship: has_participant CCO:B0001377 ! BIRC5_HUMAN relationship: has_participant CCO:B0001382 ! SEPT4_HUMAN relationship: has_participant CCO:B0001383 ! KLK10_HUMAN relationship: has_participant CCO:B0001384 ! SIAH2_HUMAN relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0001386 ! LEU2_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001390 ! MTSS1_HUMAN relationship: has_participant CCO:B0001391 ! SUV91_HUMAN relationship: has_participant CCO:B0001394 ! PRC1_HUMAN relationship: has_participant CCO:B0001395 ! BUB1_HUMAN relationship: has_participant CCO:B0001401 ! GAS2_HUMAN relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0001408 ! EVI5_HUMAN relationship: has_participant CCO:B0001409 ! DBC1_HUMAN relationship: has_participant CCO:B0001410 ! CCNT1_HUMAN relationship: has_participant CCO:B0001411 ! BUB1B_HUMAN relationship: has_participant CCO:B0001412 ! CCNT2_HUMAN relationship: has_participant CCO:B0001416 ! TRI13_HUMAN relationship: has_participant CCO:B0001420 ! PFD1_HUMAN relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001422 ! CLAP2_HUMAN relationship: has_participant CCO:B0001425 ! TACC1_HUMAN relationship: has_participant CCO:B0001426 ! CC45L_HUMAN relationship: has_participant CCO:B0001427 ! KTNA1_HUMAN relationship: has_participant CCO:B0001429 ! E2F6_HUMAN relationship: has_participant CCO:B0001432 ! GEMI_HUMAN relationship: has_participant CCO:B0001435 ! CD123_HUMAN relationship: has_participant CCO:B0001438 ! TUSC2_HUMAN relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0001440 ! DCTN3_HUMAN relationship: has_participant CCO:B0001441 ! RAD17_HUMAN relationship: has_participant CCO:B0001444 ! SASH1_HUMAN relationship: has_participant CCO:B0001446 ! CCNB2_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN relationship: has_participant CCO:B0001450 ! SMC2_HUMAN relationship: has_participant CCO:B0001452 ! O95648_HUMAN relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0001455 ! RECK_HUMAN relationship: has_participant CCO:B0001457 ! PTTG1_HUMAN relationship: has_participant CCO:B0001458 ! BCL10_HUMAN relationship: has_participant CCO:B0001459 ! CHK2_HUMAN relationship: has_participant CCO:B0001460 ! CCNE2_HUMAN relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001489 ! K1C18_HUMAN relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001494 ! S10A6_HUMAN relationship: has_participant CCO:B0001496 ! FUMH_HUMAN relationship: has_participant CCO:B0001510 ! IRF1_HUMAN relationship: has_participant CCO:B0001512 ! CDK4_HUMAN relationship: has_participant CCO:B0001519 ! CCNB1_HUMAN relationship: has_participant CCO:B0001524 ! NDKA_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0001534 ! DNL1_HUMAN relationship: has_participant CCO:B0001535 ! E2AK2_HUMAN relationship: has_participant CCO:B0001536 ! WT1_HUMAN relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001540 ! CD2L1_HUMAN relationship: has_participant CCO:B0001542 ! NF1_HUMAN relationship: has_participant CCO:B0001543 ! TAF1_HUMAN relationship: has_participant CCO:B0001546 ! NDKB_HUMAN relationship: has_participant CCO:B0001549 ! CRCM_HUMAN relationship: has_participant CCO:B0001550 ! KTHY_HUMAN relationship: has_participant CCO:B0001551 ! CCND1_HUMAN relationship: has_participant CCO:B0001552 ! GA45A_HUMAN relationship: has_participant CCO:B0001554 ! CCNE1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0001558 ! MCM3_HUMAN relationship: has_participant CCO:B0001560 ! MK03_HUMAN relationship: has_participant CCO:B0001561 ! G0S2_HUMAN relationship: has_participant CCO:B0001565 ! MK01_HUMAN relationship: has_participant CCO:B0001566 ! DUS1_HUMAN relationship: has_participant CCO:B0001567 ! RBL1_HUMAN relationship: has_participant CCO:B0001568 ! EPHB2_HUMAN relationship: has_participant CCO:B0001573 ! CCND2_HUMAN relationship: has_participant CCO:B0001574 ! CCND3_HUMAN relationship: has_participant CCO:B0001575 ! WEE1_HUMAN relationship: has_participant CCO:B0001576 ! MPIP1_HUMAN relationship: has_participant CCO:B0001577 ! MPIP2_HUMAN relationship: has_participant CCO:B0001578 ! MPIP3_HUMAN relationship: has_participant CCO:B0001582 ! MK04_HUMAN relationship: has_participant CCO:B0001586 ! CKS2_HUMAN relationship: has_participant CCO:B0001589 ! MCM7_HUMAN relationship: has_participant CCO:B0001592 ! MERL_HUMAN relationship: has_participant CCO:B0001594 ! DDIT3_HUMAN relationship: has_participant CCO:B0001595 ! AHR_HUMAN relationship: has_participant CCO:B0001596 ! PP1G_HUMAN relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0001600 ! VHL_HUMAN relationship: has_participant CCO:B0001601 ! MLH1_HUMAN relationship: has_participant CCO:B0001602 ! CCNF_HUMAN relationship: has_participant CCO:B0001604 ! CETN2_HUMAN relationship: has_participant CCO:B0001605 ! RGS2_HUMAN relationship: has_participant CCO:B0001607 ! NBL1_HUMAN relationship: has_participant CCO:B0001614 ! CNDD3_HUMAN relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0001616 ! CDN2B_HUMAN relationship: has_participant CCO:B0001617 ! CDN2C_HUMAN relationship: has_participant CCO:B0001618 ! LIS1_HUMAN relationship: has_participant CCO:B0001619 ! DCC_HUMAN relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0001622 ! KI67_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0001626 ! NASP_HUMAN relationship: has_participant CCO:B0001629 ! CENPF_HUMAN relationship: has_participant CCO:B0001630 ! CTCF_HUMAN relationship: has_participant CCO:B0001631 ! MCM2_HUMAN relationship: has_participant CCO:B0001636 ! FHIT_HUMAN relationship: has_participant CCO:B0001637 ! TSC2_HUMAN relationship: has_participant CCO:B0001638 ! DNL3_HUMAN relationship: has_participant CCO:B0001639 ! DNL4_HUMAN relationship: has_participant CCO:B0001640 ! CDN1C_HUMAN relationship: has_participant CCO:B0001644 ! CDK7_HUMAN relationship: has_participant CCO:B0001645 ! KNTC1_HUMAN relationship: has_participant CCO:B0001646 ! RASF2_HUMAN relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001652 ! CCNH_HUMAN relationship: has_participant CCO:B0001653 ! MAT1_HUMAN relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001655 ! NEK4_HUMAN relationship: has_participant CCO:B0001656 ! CCNG1_HUMAN relationship: has_participant CCO:B0001659 ! KIF11_HUMAN relationship: has_participant CCO:B0001660 ! RBM5_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN relationship: has_participant CCO:B0001665 ! MK12_HUMAN relationship: has_participant CCO:B0001666 ! HRSL3_HUMAN relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0001668 ! PMS1_HUMAN relationship: has_participant CCO:B0001669 ! PMS2_HUMAN relationship: has_participant CCO:B0001672 ! GAS1_HUMAN relationship: has_participant CCO:B0001675 ! CDN2D_HUMAN relationship: has_participant CCO:B0001679 ! HDAC4_HUMAN relationship: has_participant CCO:B0001680 ! SN1L1_HUMAN relationship: has_participant CCO:B0001684 ! MLF1_HUMAN relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0001686 ! CKS1_HUMAN relationship: has_participant CCO:B0001688 ! PP1A_HUMAN relationship: has_participant CCO:B0001689 ! PP1B_HUMAN relationship: has_participant CCO:B0001692 ! RHOB_HUMAN relationship: has_participant CCO:B0001694 ! RAP1A_HUMAN relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0001698 ! MORN_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0001702 ! TXN4A_HUMAN relationship: has_participant CCO:B0001706 ! FOXO4_HUMAN relationship: has_participant CCO:B0001707 ! CDK3_HUMAN relationship: has_participant CCO:B0001708 ! CDK6_HUMAN relationship: has_participant CCO:B0001709 ! CDK5_HUMAN relationship: has_participant CCO:B0001713 ! E2F1_HUMAN relationship: has_participant CCO:B0001715 ! CENPE_HUMAN relationship: has_participant CCO:B0001716 ! KIF23_HUMAN relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0001723 ! BAX_HUMAN relationship: has_participant CCO:B0001725 ! RBL2_HUMAN relationship: has_participant CCO:B0001727 ! RBBP4_HUMAN relationship: has_participant CCO:B0001728 ! EP300_HUMAN relationship: has_participant CCO:B0001729 ! CT069_HUMAN relationship: has_participant CCO:B0001731 ! CETN1_HUMAN relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0001733 ! CDC20_HUMAN relationship: has_participant CCO:B0001737 ! STRN3_HUMAN relationship: has_participant CCO:B0001739 ! CDC16_HUMAN relationship: has_participant CCO:B0001740 ! CSN1_HUMAN relationship: has_participant CCO:B0001742 ! CAF1A_HUMAN relationship: has_participant CCO:B0001743 ! CAF1B_HUMAN relationship: has_participant CCO:B0001746 ! GPS2_HUMAN relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0001750 ! ATM_HUMAN relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0001756 ! ATR_HUMAN relationship: has_participant CCO:B0001758 ! ULA1_HUMAN relationship: has_participant CCO:B0001763 ! CUL4B_HUMAN relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0001765 ! PTC1_HUMAN relationship: has_participant CCO:B0001775 ! SEPT6_HUMAN relationship: has_participant CCO:B0001776 ! TFDP1_HUMAN relationship: has_participant CCO:B0001777 ! TFDP2_HUMAN relationship: has_participant CCO:B0001781 ! E2F2_HUMAN relationship: has_participant CCO:B0001782 ! CASL_HUMAN relationship: has_participant CCO:B0001783 ! HIC1_HUMAN relationship: has_participant CCO:B0001784 ! DMC1_HUMAN relationship: has_participant CCO:B0001785 ! MCM6_HUMAN relationship: has_participant CCO:B0001788 ! MDC1_HUMAN relationship: has_participant CCO:B0001789 ! KANK1_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001793 ! NOLC1_HUMAN relationship: has_participant CCO:B0001796 ! HECAM_HUMAN relationship: has_participant CCO:B0001797 ! CND2_HUMAN relationship: has_participant CCO:B0001798 ! FL2D_HUMAN relationship: has_participant CCO:B0001800 ! SEPT2_HUMAN relationship: has_participant CCO:B0001801 ! CND1_HUMAN relationship: has_participant CCO:B0001807 ! DLG7_HUMAN relationship: has_participant CCO:B0001808 ! SYCP1_HUMAN relationship: has_participant CCO:B0001810 ! TERF2_HUMAN relationship: has_participant CCO:B0001811 ! MARE2_HUMAN relationship: has_participant CCO:B0001812 ! MARE1_HUMAN relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0001816 ! SEPT7_HUMAN relationship: has_participant CCO:B0001817 ! E2F4_HUMAN relationship: has_participant CCO:B0001818 ! EXT1_HUMAN relationship: has_participant CCO:B0001821 ! CCNG2_HUMAN relationship: has_participant CCO:B0001822 ! MK06_HUMAN relationship: has_participant CCO:B0001823 ! CDKN3_HUMAN relationship: has_participant CCO:B0001827 ! Q1WWK5_HUMAN relationship: has_participant CCO:B0001829 ! PDS5A_HUMAN relationship: has_participant CCO:B0001831 ! Q3LRW5_HUMAN relationship: has_participant CCO:B0001832 ! TBRG1_HUMAN relationship: has_participant CCO:B0001834 ! MAP9_HUMAN relationship: has_participant CCO:B0001836 ! PDCD4_HUMAN relationship: has_participant CCO:B0001837 ! CEP55_HUMAN relationship: has_participant CCO:B0001838 ! PKHO1_HUMAN relationship: has_participant CCO:B0001839 ! BOREA_HUMAN relationship: has_participant CCO:B0001840 ! SGOL2_HUMAN relationship: has_participant CCO:B0001841 ! ESCO2_HUMAN relationship: has_participant CCO:B0001845 ! Q59FW7_HUMAN relationship: has_participant CCO:B0001846 ! Q59GE1_HUMAN relationship: has_participant CCO:B0001847 ! SGOL1_HUMAN relationship: has_participant CCO:B0001848 ! ESCO1_HUMAN relationship: has_participant CCO:B0001861 ! SPDYC_HUMAN relationship: has_participant CCO:B0001862 ! SPDYA_HUMAN relationship: has_participant CCO:B0001867 ! Q5T179_HUMAN relationship: has_participant CCO:B0001879 ! AVPI1_HUMAN relationship: has_participant CCO:B0001883 ! QN1_HUMAN relationship: has_participant CCO:B0001894 ! LIN9_HUMAN relationship: has_participant CCO:B0001895 ! CROCC_HUMAN relationship: has_participant CCO:B0001896 ! Q5TZP9_HUMAN relationship: has_participant CCO:B0001897 ! RIF1_HUMAN relationship: has_participant CCO:B0001899 ! DAB2P_HUMAN relationship: has_participant CCO:B0001901 ! Q5W161_HUMAN relationship: has_participant CCO:B0001902 ! POLS_HUMAN relationship: has_participant CCO:B0001903 ! STEA3_HUMAN relationship: has_participant CCO:B0001904 ! KCD11_HUMAN relationship: has_participant CCO:B0001905 ! CDCA2_HUMAN relationship: has_participant CCO:B0001906 ! CYTSA_HUMAN relationship: has_participant CCO:B0001908 ! NIPBL_HUMAN relationship: has_participant CCO:B0001909 ! RINT1_HUMAN relationship: has_participant CCO:B0001910 ! Q6NVV2_HUMAN relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0001912 ! PMF1_HUMAN relationship: has_participant CCO:B0001913 ! L2GL2_HUMAN relationship: has_participant CCO:B0001914 ! BORA_HUMAN relationship: has_participant CCO:B0001915 ! SYCE2_HUMAN relationship: has_participant CCO:B0001916 ! DCR1A_HUMAN relationship: has_participant CCO:B0001918 ! SAS6_HUMAN relationship: has_participant CCO:B0001922 ! TM11A_HUMAN relationship: has_participant CCO:B0001925 ! SEP14_HUMAN relationship: has_participant CCO:B0001930 ! MAEA_HUMAN relationship: has_participant CCO:B0001931 ! VASH1_HUMAN relationship: has_participant CCO:B0001932 ! STRAD_HUMAN relationship: has_participant CCO:B0001933 ! CLAP1_HUMAN relationship: has_participant CCO:B0001935 ! Q7Z774_HUMAN relationship: has_participant CCO:B0001939 ! TLK2_HUMAN relationship: has_participant CCO:B0001940 ! CUZD1_HUMAN relationship: has_participant CCO:B0001941 ! NIPA_HUMAN relationship: has_participant CCO:B0001943 ! CNDG2_HUMAN relationship: has_participant CCO:B0001946 ! SIAH1_HUMAN relationship: has_participant CCO:B0001947 ! EGFL6_HUMAN relationship: has_participant CCO:B0001950 ! CCAR1_HUMAN relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0001952 ! RM41_HUMAN relationship: has_participant CCO:B0001954 ! XRN1_HUMAN relationship: has_participant CCO:B0001955 ! CCRK_HUMAN relationship: has_participant CCO:B0001956 ! ASPM_HUMAN relationship: has_participant CCO:B0001957 ! SYCP3_HUMAN relationship: has_participant CCO:B0001959 ! TAF1L_HUMAN relationship: has_participant CCO:B0001960 ! SYCE1_HUMAN relationship: has_participant CCO:B0001961 ! CNTRB_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0001963 ! KIF2B_HUMAN relationship: has_participant CCO:B0001966 ! CD2A2_HUMAN relationship: has_participant CCO:B0001969 ! Q8N855_HUMAN relationship: has_participant CCO:B0001971 ! BANP_HUMAN relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0001975 ! PAPD5_HUMAN relationship: has_participant CCO:B0001976 ! RCBT1_HUMAN relationship: has_participant CCO:B0001977 ! SMC1B_HUMAN relationship: has_participant CCO:B0001978 ! PPC1B_HUMAN relationship: has_participant CCO:B0001980 ! DP13B_HUMAN relationship: has_participant CCO:B0001981 ! FLCN_HUMAN relationship: has_participant CCO:B0001982 ! Q8NFI1_HUMAN relationship: has_participant CCO:B0001983 ! CADM4_HUMAN relationship: has_participant CCO:B0001984 ! NEK11_HUMAN relationship: has_participant CCO:B0001986 ! CDC26_HUMAN relationship: has_participant CCO:B0001987 ! G45IP_HUMAN relationship: has_participant CCO:B0001989 ! UBA3_HUMAN relationship: has_participant CCO:B0001991 ! NEK9_HUMAN relationship: has_participant CCO:B0001994 ! CABL1_HUMAN relationship: has_participant CCO:B0001995 ! RBCC1_HUMAN relationship: has_participant CCO:B0001996 ! PARD3_HUMAN relationship: has_participant CCO:B0001997 ! PAR3L_HUMAN relationship: has_participant CCO:B0001999 ! HASP_HUMAN relationship: has_participant CCO:B0002000 ! TUSC4_HUMAN relationship: has_participant CCO:B0002001 ! Q8WUE3_HUMAN relationship: has_participant CCO:B0002003 ! SKA2_HUMAN relationship: has_participant CCO:B0002004 ! STAG1_HUMAN relationship: has_participant CCO:B0002005 ! PCNP_HUMAN relationship: has_participant CCO:B0002006 ! CKAP2_HUMAN relationship: has_participant CCO:B0002007 ! CCNB3_HUMAN relationship: has_participant CCO:B0002008 ! RASF5_HUMAN relationship: has_participant CCO:B0002011 ! SEPT1_HUMAN relationship: has_participant CCO:B0002014 ! TSC1_HUMAN relationship: has_participant CCO:B0002015 ! SEPT8_HUMAN relationship: has_participant CCO:B0002017 ! DDX12_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0002021 ! RAD50_HUMAN relationship: has_participant CCO:B0002024 ! RENT1_HUMAN relationship: has_participant CCO:B0002026 ! NAT6_HUMAN relationship: has_participant CCO:B0002028 ! EXT2_HUMAN relationship: has_participant CCO:B0002029 ! TP4A1_HUMAN relationship: has_participant CCO:B0002031 ! E2F7_HUMAN relationship: has_participant CCO:B0002032 ! SKA1_HUMAN relationship: has_participant CCO:B0002033 ! PINX1_HUMAN relationship: has_participant CCO:B0002034 ! CCDC5_HUMAN relationship: has_participant CCO:B0002035 ! CHFR_HUMAN relationship: has_participant CCO:B0002037 ! DDX11_HUMAN relationship: has_participant CCO:B0002038 ! CDCA5_HUMAN relationship: has_participant CCO:B0002040 ! AURKB_HUMAN relationship: has_participant CCO:B0002041 ! SENP5_HUMAN relationship: has_participant CCO:B0002042 ! SGSM3_HUMAN relationship: has_participant CCO:B0002043 ! NSL1_HUMAN relationship: has_participant CCO:B0002047 ! LMLN_HUMAN relationship: has_participant CCO:B0002050 ! Q96MY5_HUMAN relationship: has_participant CCO:B0002051 ! CCD16_HUMAN relationship: has_participant CCO:B0002054 ! UHRF2_HUMAN relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0002056 ! MPPH1_HUMAN relationship: has_participant CCO:B0002057 ! Q96Q97_HUMAN relationship: has_participant CCO:B0002058 ! SPAG5_HUMAN relationship: has_participant CCO:B0002059 ! LAP2_HUMAN relationship: has_participant CCO:B0002063 ! UHRF1_HUMAN relationship: has_participant CCO:B0002065 ! CDC5L_HUMAN relationship: has_participant CCO:B0002070 ! ZWIA_HUMAN relationship: has_participant CCO:B0002072 ! MPP8_HUMAN relationship: has_participant CCO:B0002076 ! CDCA3_HUMAN relationship: has_participant CCO:B0002078 ! PMYT1_HUMAN relationship: has_participant CCO:B0002079 ! Q99648_HUMAN relationship: has_participant CCO:B0002081 ! CGRE1_HUMAN relationship: has_participant CCO:B0002082 ! CGRF1_HUMAN relationship: has_participant CCO:B0002085 ! SEPT5_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0002090 ! SPI2A_HUMAN relationship: has_participant CCO:B0002092 ! CND3_HUMAN relationship: has_participant CCO:B0002093 ! SPI2B_HUMAN relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN relationship: has_participant CCO:B0002095 ! APC13_HUMAN relationship: has_participant CCO:B0002097 ! CABL2_HUMAN relationship: has_participant CCO:B0002098 ! HTAI2_HUMAN relationship: has_participant CCO:B0002099 ! CP250_HUMAN relationship: has_participant CCO:B0002100 ! KTNB1_HUMAN relationship: has_participant CCO:B0002104 ! TIPIN_HUMAN relationship: has_participant CCO:B0002105 ! KIFC1_HUMAN relationship: has_participant CCO:B0002106 ! SYCP2_HUMAN relationship: has_participant CCO:B0002108 ! NUSAP_HUMAN relationship: has_participant CCO:B0002109 ! FACD2_HUMAN relationship: has_participant CCO:B0002110 ! CADM1_HUMAN relationship: has_participant CCO:B0002112 ! PAR6G_HUMAN relationship: has_participant CCO:B0002113 ! PAR6B_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN relationship: has_participant CCO:B0002117 ! DPH1_HUMAN relationship: has_participant CCO:B0002118 ! Q9BZU3_HUMAN relationship: has_participant CCO:B0002119 ! AL2S2_HUMAN relationship: has_participant CCO:B0002122 ! MIS12_HUMAN relationship: has_participant CCO:B0002124 ! RGAP1_HUMAN relationship: has_participant CCO:B0002125 ! APC1_HUMAN relationship: has_participant CCO:B0002126 ! CDT1_HUMAN relationship: has_participant CCO:B0002128 ! TSYL2_HUMAN relationship: has_participant CCO:B0002129 ! RASF4_HUMAN relationship: has_participant CCO:B0002131 ! PININ_HUMAN relationship: has_participant CCO:B0002132 ! Q9H315_HUMAN relationship: has_participant CCO:B0002133 ! TXNIP_HUMAN relationship: has_participant CCO:B0002134 ! DSN1_HUMAN relationship: has_participant CCO:B0002137 ! RGC32_HUMAN relationship: has_participant CCO:B0002139 ! SUV92_HUMAN relationship: has_participant CCO:B0002142 ! CLSPN_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN relationship: has_participant CCO:B0002145 ! NEK6_HUMAN relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0002148 ! CHM1A_HUMAN relationship: has_participant CCO:B0002150 ! PAR6A_HUMAN relationship: has_participant CCO:B0002153 ! CYLD_HUMAN relationship: has_participant CCO:B0002154 ! INCE_HUMAN relationship: has_participant CCO:B0002155 ! ANLN_HUMAN relationship: has_participant CCO:B0002156 ! BIN3_HUMAN relationship: has_participant CCO:B0002159 ! LATS2_HUMAN relationship: has_participant CCO:B0002160 ! GRLF1_HUMAN relationship: has_participant CCO:B0002161 ! HELLS_HUMAN relationship: has_participant CCO:B0002162 ! RASF1_HUMAN relationship: has_participant CCO:B0002166 ! Q9NSH2_HUMAN relationship: has_participant CCO:B0002168 ! SMC4_HUMAN relationship: has_participant CCO:B0002169 ! SEP11_HUMAN relationship: has_participant CCO:B0002170 ! FANCI_HUMAN relationship: has_participant CCO:B0002172 ! TXN4B_HUMAN relationship: has_participant CCO:B0002173 ! NDE1_HUMAN relationship: has_participant CCO:B0002175 ! NSMA2_HUMAN relationship: has_participant CCO:B0002177 ! APC11_HUMAN relationship: has_participant CCO:B0002178 ! MLTK_HUMAN relationship: has_participant CCO:B0002181 ! WWOX_HUMAN relationship: has_participant CCO:B0002182 ! SH3B4_HUMAN relationship: has_participant CCO:B0002183 ! SEP10_HUMAN relationship: has_participant CCO:B0002184 ! HM20B_HUMAN relationship: has_participant CCO:B0002186 ! RCC2_HUMAN relationship: has_participant CCO:B0002187 ! BCCIP_HUMAN relationship: has_participant CCO:B0002188 ! RHG20_HUMAN relationship: has_participant CCO:B0002189 ! DEC1_HUMAN relationship: has_participant CCO:B0002192 ! HDAC6_HUMAN relationship: has_participant CCO:B0002194 ! DBF4A_HUMAN relationship: has_participant CCO:B0002197 ! DMBT1_HUMAN relationship: has_participant CCO:B0002198 ! SEPT3_HUMAN relationship: has_participant CCO:B0002201 ! SEPT9_HUMAN relationship: has_participant CCO:B0002204 ! MD2L2_HUMAN relationship: has_participant CCO:B0002205 ! MUTYH_HUMAN relationship: has_participant CCO:B0002209 ! STAG3_HUMAN relationship: has_participant CCO:B0002210 ! MCM8_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0002213 ! APC7_HUMAN relationship: has_participant CCO:B0002214 ! APC5_HUMAN relationship: has_participant CCO:B0002215 ! APC4_HUMAN relationship: has_participant CCO:B0002216 ! ANC2_HUMAN relationship: has_participant CCO:B0002217 ! ING1_HUMAN relationship: has_participant CCO:B0002219 ! DP13A_HUMAN relationship: has_participant CCO:B0002220 ! TLK1_HUMAN relationship: has_participant CCO:B0002221 ! FBX5_HUMAN relationship: has_participant CCO:B0002224 ! MTUS1_HUMAN relationship: has_participant CCO:B0002225 ! CCPG1_HUMAN relationship: has_participant CCO:B0002228 ! ASC_HUMAN relationship: has_participant CCO:B0002229 ! FZR_HUMAN relationship: has_participant CCO:B0002230 ! APC10_HUMAN relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0002233 ! CC14A_HUMAN relationship: has_participant CCO:B0002234 ! ING4_HUMAN relationship: has_participant CCO:B0002235 ! TIM_HUMAN relationship: has_participant CCO:B0002238 ! MARE3_HUMAN relationship: has_participant CCO:B0002241 ! CD2L2_HUMAN relationship: has_participant CCO:B0002242 ! AURKC_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0002245 ! JAG2_HUMAN relationship: has_participant CCO:B0002247 ! DLEC1_HUMAN relationship: has_participant CCO:B0002248 ! LZTS1_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0002250 ! NUDC_HUMAN relationship: has_participant CCO:B0002253 ! STA13_HUMAN relationship: has_participant CCO:B0002254 ! RBGP1_HUMAN relationship: has_participant CCO:B0002257 ! CD2AP_HUMAN relationship: has_participant CCO:B0002259 ! UBP16_HUMAN relationship: has_participant CCO:B0002262 ! SPIN1_HUMAN relationship: has_participant CCO:B0002263 ! EID1_HUMAN relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0021356 ! Q8IY91_HUMAN relationship: has_participant CCO:B0022308 ! Q1MSW9_HUMAN relationship: has_participant CCO:B0023340 ! Q59H84_HUMAN relationship: has_participant CCO:B0023347 ! Q9H9P7_HUMAN relationship: has_participant CCO:B0023348 ! Q8NFH9_HUMAN relationship: has_participant CCO:B0023351 ! Q6B514_HUMAN relationship: has_participant CCO:B0023650 ! Q53QU3_HUMAN relationship: has_participant CCO:B0026249 ! ZMY11_HUMAN relationship: has_participant CCO:B0026250 ! Q5JXL7_HUMAN relationship: has_participant CCO:B0026252 ! NOXIN_HUMAN relationship: has_participant CCO:B0026253 ! SEP12_HUMAN relationship: has_participant CCO:B0026254 ! JUB_HUMAN relationship: has_participant CCO:B0026257 ! PDS5B_HUMAN relationship: has_participant CCO:B0028285 ! A8MT51_HUMAN relationship: has_participant CCO:B0030400 ! A8K7M3_HUMAN relationship: has_participant CCO:B0032821 ! ZWILC_HUMAN relationship: has_participant CCO:B0033478 ! DBF4B_HUMAN relationship: has_participant CCO:B0033797 ! Q548C9_HUMAN relationship: has_participant CCO:B0033798 ! Q541S4_HUMAN relationship: has_participant CCO:B0035936 ! RNF8_HUMAN relationship: has_participant CCO:B0035938 ! SETD8_HUMAN relationship: has_participant CCO:B0035939 ! C8AP2_HUMAN relationship: has_participant CCO:B0039945 ! CRBL2_HUMAN relationship: has_participant CCO:B0039946 ! NPAT_HUMAN relationship: has_participant CCO:B0039949 ! FSD1_HUMAN relationship: has_participant CCO:B0039950 ! DCC1_HUMAN relationship: has_participant CCO:B0041227 ! B1AHR1_HUMAN relationship: has_participant CCO:B0041234 ! B1AMS2_HUMAN relationship: has_participant CCO:B0041241 ! CCDB1_HUMAN relationship: has_participant CCO:B0041249 ! HMGA2_HUMAN relationship: has_participant CCO:B0041254 ! PTOR1_HUMAN relationship: has_participant CCO:B0041256 ! ERC6L_HUMAN relationship: has_participant CCO:B0041257 ! E4F1_HUMAN relationship: has_participant CCO:B0041258 ! XAF1_HUMAN relationship: has_participant CCO:B0041260 ! CP110_HUMAN relationship: has_participant CCO:B0041261 ! ERF3B_HUMAN relationship: has_participant CCO:B0041262 ! CTF8_HUMAN relationship: has_participant CCO:B0041264 ! PRDBP_HUMAN relationship: has_participant CCO:B0041265 ! MTBP_HUMAN relationship: has_participant CCO:B0041266 ! CINP_HUMAN relationship: has_participant CCO:B0041267 ! DMTF1_HUMAN [Term] id: CCO:P0000067 name: cell cycle arrest namespace: biological_process def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb] synonym: "arrest of cell cycle progression" EXACT [] synonym: "cessation of cell cycle" EXACT [] synonym: "termination of cell cycle" EXACT [] xref: GO:0007050 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001333 ! A6NK88_HUMAN relationship: has_participant CCO:B0001343 ! A7KMP4_HUMAN relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0001375 ! PPM1G_HUMAN relationship: has_participant CCO:B0001388 ! SNUT1_HUMAN relationship: has_participant CCO:B0001401 ! GAS2_HUMAN relationship: has_participant CCO:B0001407 ! HBP1_HUMAN relationship: has_participant CCO:B0001409 ! DBC1_HUMAN relationship: has_participant CCO:B0001417 ! GAS7_HUMAN relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001428 ! ERN1_HUMAN relationship: has_participant CCO:B0001435 ! CD123_HUMAN relationship: has_participant CCO:B0001436 ! PR15A_HUMAN relationship: has_participant CCO:B0001443 ! BPAEA_HUMAN relationship: has_participant CCO:B0001465 ! MYC_HUMAN relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001484 ! IFNW1_HUMAN relationship: has_participant CCO:B0001485 ! INHA_HUMAN relationship: has_participant CCO:B0001498 ! INHBA_HUMAN relationship: has_participant CCO:B0001504 ! IL8_HUMAN relationship: has_participant CCO:B0001552 ! GA45A_HUMAN relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0001594 ! DDIT3_HUMAN relationship: has_participant CCO:B0001599 ! CDN1A_HUMAN relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0001624 ! CDN1B_HUMAN relationship: has_participant CCO:B0001640 ! CDN1C_HUMAN relationship: has_participant CCO:B0001658 ! MP2K6_HUMAN relationship: has_participant CCO:B0001665 ! MK12_HUMAN relationship: has_participant CCO:B0001672 ! GAS1_HUMAN relationship: has_participant CCO:B0001673 ! AIF1_HUMAN relationship: has_participant CCO:B0001681 ! SESN2_HUMAN relationship: has_participant CCO:B0001682 ! SESN3_HUMAN relationship: has_participant CCO:B0001684 ! MLF1_HUMAN relationship: has_participant CCO:B0001699 ! IF4G2_HUMAN relationship: has_participant CCO:B0001706 ! FOXO4_HUMAN relationship: has_participant CCO:B0001719 ! NOTC2_HUMAN relationship: has_participant CCO:B0001722 ! KHDR1_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0001760 ! CUL2_HUMAN relationship: has_participant CCO:B0001761 ! CUL3_HUMAN relationship: has_participant CCO:B0001762 ! CUL4A_HUMAN relationship: has_participant CCO:B0001796 ! HECAM_HUMAN relationship: has_participant CCO:B0001806 ! DHC24_HUMAN relationship: has_participant CCO:B0001814 ! STK11_HUMAN relationship: has_participant CCO:B0001823 ! CDKN3_HUMAN relationship: has_participant CCO:B0001832 ! TBRG1_HUMAN relationship: has_participant CCO:B0001872 ! Q5T317_HUMAN relationship: has_participant CCO:B0001884 ! Q5TBT1_HUMAN relationship: has_participant CCO:B0001885 ! Q5TBT2_HUMAN relationship: has_participant CCO:B0001924 ! Q6ZQZ4_HUMAN relationship: has_participant CCO:B0001931 ! VASH1_HUMAN relationship: has_participant CCO:B0001944 ! GA2L3_HUMAN relationship: has_participant CCO:B0001985 ! GA2L2_HUMAN relationship: has_participant CCO:B0001988 ! UHMK1_HUMAN relationship: has_participant CCO:B0001998 ! Q8TEY4_HUMAN relationship: has_participant CCO:B0002019 ! PCAF_HUMAN relationship: has_participant CCO:B0002020 ! APBB2_HUMAN relationship: has_participant CCO:B0002027 ! CUL5_HUMAN relationship: has_participant CCO:B0002030 ! TBRG4_HUMAN relationship: has_participant CCO:B0002042 ! SGSM3_HUMAN relationship: has_participant CCO:B0002048 ! Q96LE1_HUMAN relationship: has_participant CCO:B0002053 ! MACF4_HUMAN relationship: has_participant CCO:B0002056 ! MPPH1_HUMAN relationship: has_participant CCO:B0002060 ! NEB2_HUMAN relationship: has_participant CCO:B0002067 ! GA2L1_HUMAN relationship: has_participant CCO:B0002081 ! CGRE1_HUMAN relationship: has_participant CCO:B0002082 ! CGRF1_HUMAN relationship: has_participant CCO:B0002086 ! BARD1_HUMAN relationship: has_participant CCO:B0002096 ! Q9BSP9_HUMAN relationship: has_participant CCO:B0002121 ! Q9GZT1_HUMAN relationship: has_participant CCO:B0002141 ! Q9H8U2_HUMAN relationship: has_participant CCO:B0002162 ! RASF1_HUMAN relationship: has_participant CCO:B0002174 ! BTG4_HUMAN relationship: has_participant CCO:B0002178 ! MLTK_HUMAN relationship: has_participant CCO:B0002231 ! PLAL1_HUMAN relationship: has_participant CCO:B0002234 ! ING4_HUMAN relationship: has_participant CCO:B0002237 ! MACF1_HUMAN relationship: has_participant CCO:B0002239 ! PA2G4_HUMAN relationship: has_participant CCO:B0002258 ! P2R3B_HUMAN relationship: has_participant CCO:B0002266 ! SESN1_HUMAN relationship: has_participant CCO:B0026252 ! NOXIN_HUMAN relationship: has_participant CCO:B0026256 ! RPRM_HUMAN relationship: has_participant CCO:B0040022 ! JMY_HUMAN relationship: has_participant CCO:B0041233 ! B1ALC7_HUMAN relationship: has_participant CCO:B0041235 ! B1ANQ7_HUMAN relationship: has_participant CCO:B0041236 ! B1ANR2_HUMAN relationship: has_participant CCO:B0041265 ! MTBP_HUMAN [Term] id: CCO:P0000068 name: mitotic spindle organization and biogenesis namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] synonym: "mitotic spindle organisation and biogenesis" EXACT [] synonym: "spindle organization and biogenesis during mitosis" EXACT [] xref: GO:0007052 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001528 ! STMN1_HUMAN relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0001587 ! TTK_HUMAN relationship: has_participant CCO:B0001659 ! KIF11_HUMAN relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0001780 ! DYHC1_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0002199 ! UN84B_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: part_of CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000069 name: spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] synonym: "male meiotic spindle assembly (sensu Metazoa)" RELATED [] xref: GO:0007053 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000131 ! male meiosis [Term] id: CCO:P0000070 name: spindle assembly involved in male meiosis I namespace: biological_process def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] synonym: "male meiosis I spindle assembly (sensu Metazoa)" RELATED [] xref: GO:0007054 is_a: CCO:P0000069 ! spindle assembly involved in male meiosis relationship: part_of CCO:P0000132 ! male meiosis I [Term] id: CCO:P0000071 name: spindle assembly involved male meiosis II namespace: biological_process def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] synonym: "male meiosis II spindle assembly (sensu Metazoa)" RELATED [] xref: GO:0007055 is_a: CCO:P0000069 ! spindle assembly involved in male meiosis relationship: part_of CCO:P0000133 ! male meiosis II [Term] id: CCO:P0000072 name: spindle assembly involved in female meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] synonym: "female meiotic spindle assembly (sensu Metazoa)" RELATED [] xref: GO:0007056 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000134 ! female meiosis [Term] id: CCO:P0000073 name: spindle assembly involved in female meiosis I namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] synonym: "female meiosis I spindle assembly (sensu Metazoa)" RELATED [] xref: GO:0007057 is_a: CCO:P0000072 ! spindle assembly involved in female meiosis relationship: part_of CCO:P0000135 ! female meiosis I [Term] id: CCO:P0000074 name: spindle assembly involved in female meiosis II namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] synonym: "female meiosis II spindle assembly (sensu Metazoa)" RELATED [] xref: GO:0007058 is_a: CCO:P0000072 ! spindle assembly involved in female meiosis relationship: part_of CCO:P0000137 ! female meiosis II [Term] id: CCO:P0000075 name: male meiosis chromosome segregation namespace: biological_process def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai] xref: GO:0007060 is_a: CCO:P0000159 ! cell cycle process is_a: CCO:P0000237 ! meiotic chromosome segregation relationship: part_of CCO:P0000131 ! male meiosis [Term] id: CCO:P0000076 name: sister chromatid cohesion namespace: biological_process def: "The cell cycle process by which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome." [GOC:mah, ISBN:0815316194] xref: GO:0007062 xref: Reactome:163048 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001447 ! REC8_HUMAN relationship: has_participant CCO:B0001902 ! POLS_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN [Term] id: CCO:P0000077 name: regulation of sister chromatid cohesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] xref: GO:0007063 is_a: CCO:P0000382 ! regulation of cell cycle process relationship: regulates CCO:P0000076 ! sister chromatid cohesion [Term] id: CCO:P0000078 name: mitotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] xref: GO:0007064 is_a: CCO:P0000076 ! sister chromatid cohesion relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0026257 ! PDS5B_HUMAN relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000079 name: male meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai] xref: GO:0007065 is_a: CCO:P0000289 ! meiotic sister chromatid cohesion relationship: part_of CCO:P0000131 ! male meiosis [Term] id: CCO:P0000080 name: female meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai] xref: GO:0007066 is_a: CCO:P0000289 ! meiotic sister chromatid cohesion relationship: part_of CCO:P0000134 ! female meiosis [Term] id: CCO:P0000081 name: mitosis namespace: biological_process def: "Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:ma, ISBN:0198547684] xref: GO:0007067 is_a: CCO:P0000160 ! cell cycle phase relationship: has_participant CCO:B0001321 ! A6NE16_HUMAN relationship: has_participant CCO:B0001334 ! SAC31_HUMAN relationship: has_participant CCO:B0001340 ! A6NMK2_HUMAN relationship: has_participant CCO:B0001354 ! UBE2C_HUMAN relationship: has_participant CCO:B0001356 ! CTRO_HUMAN relationship: has_participant CCO:B0001360 ! NDC80_HUMAN relationship: has_participant CCO:B0001361 ! O14835_HUMAN relationship: has_participant CCO:B0001363 ! STK6_HUMAN relationship: has_participant CCO:B0001368 ! CETN3_HUMAN relationship: has_participant CCO:B0001377 ! BIRC5_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001395 ! BUB1_HUMAN relationship: has_participant CCO:B0001396 ! BUB3_HUMAN relationship: has_participant CCO:B0001399 ! AKAP8_HUMAN relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001405 ! SSA27_HUMAN relationship: has_participant CCO:B0001411 ! BUB1B_HUMAN relationship: has_participant CCO:B0001422 ! CLAP2_HUMAN relationship: has_participant CCO:B0001427 ! KTNA1_HUMAN relationship: has_participant CCO:B0001439 ! CCNK_HUMAN relationship: has_participant CCO:B0001440 ! DCTN3_HUMAN relationship: has_participant CCO:B0001446 ! CCNB2_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN relationship: has_participant CCO:B0001450 ! SMC2_HUMAN relationship: has_participant CCO:B0001451 ! YETS4_HUMAN relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0001457 ! PTTG1_HUMAN relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001518 ! HGF_HUMAN relationship: has_participant CCO:B0001519 ! CCNB1_HUMAN relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN relationship: has_participant CCO:B0001540 ! CD2L1_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001575 ! WEE1_HUMAN relationship: has_participant CCO:B0001576 ! MPIP1_HUMAN relationship: has_participant CCO:B0001577 ! MPIP2_HUMAN relationship: has_participant CCO:B0001578 ! MPIP3_HUMAN relationship: has_participant CCO:B0001580 ! CLIP1_HUMAN relationship: has_participant CCO:B0001602 ! CCNF_HUMAN relationship: has_participant CCO:B0001604 ! CETN2_HUMAN relationship: has_participant CCO:B0001614 ! CNDD3_HUMAN relationship: has_participant CCO:B0001618 ! LIS1_HUMAN relationship: has_participant CCO:B0001629 ! CENPF_HUMAN relationship: has_participant CCO:B0001645 ! KNTC1_HUMAN relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001655 ! NEK4_HUMAN relationship: has_participant CCO:B0001656 ! CCNG1_HUMAN relationship: has_participant CCO:B0001659 ! KIF11_HUMAN relationship: has_participant CCO:B0001662 ! PPP5_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN relationship: has_participant CCO:B0001667 ! TERF1_HUMAN relationship: has_participant CCO:B0001693 ! RAN_HUMAN relationship: has_participant CCO:B0001696 ! UBC9_HUMAN relationship: has_participant CCO:B0001698 ! MORN_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0001702 ! TXN4A_HUMAN relationship: has_participant CCO:B0001707 ! CDK3_HUMAN relationship: has_participant CCO:B0001715 ! CENPE_HUMAN relationship: has_participant CCO:B0001716 ! KIF23_HUMAN relationship: has_participant CCO:B0001731 ! CETN1_HUMAN relationship: has_participant CCO:B0001733 ! CDC20_HUMAN relationship: has_participant CCO:B0001739 ! CDC16_HUMAN relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0001779 ! DCTN1_HUMAN relationship: has_participant CCO:B0001782 ! CASL_HUMAN relationship: has_participant CCO:B0001786 ! Q14569_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001792 ! KIF22_HUMAN relationship: has_participant CCO:B0001793 ! NOLC1_HUMAN relationship: has_participant CCO:B0001797 ! CND2_HUMAN relationship: has_participant CCO:B0001801 ! CND1_HUMAN relationship: has_participant CCO:B0001811 ! MARE2_HUMAN relationship: has_participant CCO:B0001812 ! MARE1_HUMAN relationship: has_participant CCO:B0001821 ! CCNG2_HUMAN relationship: has_participant CCO:B0001829 ! PDS5A_HUMAN relationship: has_participant CCO:B0001834 ! MAP9_HUMAN relationship: has_participant CCO:B0001837 ! CEP55_HUMAN relationship: has_participant CCO:B0001839 ! BOREA_HUMAN relationship: has_participant CCO:B0001847 ! SGOL1_HUMAN relationship: has_participant CCO:B0001883 ! QN1_HUMAN relationship: has_participant CCO:B0001902 ! POLS_HUMAN relationship: has_participant CCO:B0001905 ! CDCA2_HUMAN relationship: has_participant CCO:B0001912 ! PMF1_HUMAN relationship: has_participant CCO:B0001914 ! BORA_HUMAN relationship: has_participant CCO:B0001916 ! DCR1A_HUMAN relationship: has_participant CCO:B0001926 ! Q6ZV00_HUMAN relationship: has_participant CCO:B0001933 ! CLAP1_HUMAN relationship: has_participant CCO:B0001938 ! PB1_HUMAN relationship: has_participant CCO:B0001941 ! NIPA_HUMAN relationship: has_participant CCO:B0001942 ! HORM1_HUMAN relationship: has_participant CCO:B0001943 ! CNDG2_HUMAN relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0001956 ! ASPM_HUMAN relationship: has_participant CCO:B0001958 ! Q8IZX3_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0001963 ! KIF2B_HUMAN relationship: has_participant CCO:B0001967 ! HORM2_HUMAN relationship: has_participant CCO:B0001973 ! SPC24_HUMAN relationship: has_participant CCO:B0001975 ! PAPD5_HUMAN relationship: has_participant CCO:B0001986 ! CDC26_HUMAN relationship: has_participant CCO:B0001991 ! NEK9_HUMAN relationship: has_participant CCO:B0002003 ! SKA2_HUMAN relationship: has_participant CCO:B0002004 ! STAG1_HUMAN relationship: has_participant CCO:B0002013 ! TITIN_HUMAN relationship: has_participant CCO:B0002032 ! SKA1_HUMAN relationship: has_participant CCO:B0002034 ! CCDC5_HUMAN relationship: has_participant CCO:B0002035 ! CHFR_HUMAN relationship: has_participant CCO:B0002038 ! CDCA5_HUMAN relationship: has_participant CCO:B0002040 ! AURKB_HUMAN relationship: has_participant CCO:B0002043 ! NSL1_HUMAN relationship: has_participant CCO:B0002045 ! TOPK_HUMAN relationship: has_participant CCO:B0002047 ! LMLN_HUMAN relationship: has_participant CCO:B0002051 ! CCD16_HUMAN relationship: has_participant CCO:B0002055 ! NEK1_HUMAN relationship: has_participant CCO:B0002056 ! MPPH1_HUMAN relationship: has_participant CCO:B0002058 ! SPAG5_HUMAN relationship: has_participant CCO:B0002076 ! CDCA3_HUMAN relationship: has_participant CCO:B0002078 ! PMYT1_HUMAN relationship: has_participant CCO:B0002080 ! KIF2C_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: has_participant CCO:B0002092 ! CND3_HUMAN relationship: has_participant CCO:B0002095 ! APC13_HUMAN relationship: has_participant CCO:B0002100 ! KTNB1_HUMAN relationship: has_participant CCO:B0002104 ! TIPIN_HUMAN relationship: has_participant CCO:B0002105 ! KIFC1_HUMAN relationship: has_participant CCO:B0002108 ! NUSAP_HUMAN relationship: has_participant CCO:B0002115 ! NUF2_HUMAN relationship: has_participant CCO:B0002122 ! MIS12_HUMAN relationship: has_participant CCO:B0002125 ! APC1_HUMAN relationship: has_participant CCO:B0002134 ! DSN1_HUMAN relationship: has_participant CCO:B0002143 ! SPC25_HUMAN relationship: has_participant CCO:B0002144 ! EMAL4_HUMAN relationship: has_participant CCO:B0002145 ! NEK6_HUMAN relationship: has_participant CCO:B0002154 ! INCE_HUMAN relationship: has_participant CCO:B0002155 ! ANLN_HUMAN relationship: has_participant CCO:B0002159 ! LATS2_HUMAN relationship: has_participant CCO:B0002161 ! HELLS_HUMAN relationship: has_participant CCO:B0002165 ! KIF15_HUMAN relationship: has_participant CCO:B0002168 ! SMC4_HUMAN relationship: has_participant CCO:B0002172 ! TXN4B_HUMAN relationship: has_participant CCO:B0002173 ! NDE1_HUMAN relationship: has_participant CCO:B0002177 ! APC11_HUMAN relationship: has_participant CCO:B0002186 ! RCC2_HUMAN relationship: has_participant CCO:B0002204 ! MD2L2_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0002213 ! APC7_HUMAN relationship: has_participant CCO:B0002214 ! APC5_HUMAN relationship: has_participant CCO:B0002215 ! APC4_HUMAN relationship: has_participant CCO:B0002216 ! ANC2_HUMAN relationship: has_participant CCO:B0002221 ! FBX5_HUMAN relationship: has_participant CCO:B0002227 ! TPX2_HUMAN relationship: has_participant CCO:B0002229 ! FZR_HUMAN relationship: has_participant CCO:B0002230 ! APC10_HUMAN relationship: has_participant CCO:B0002235 ! TIM_HUMAN relationship: has_participant CCO:B0002238 ! MARE3_HUMAN relationship: has_participant CCO:B0002241 ! CD2L2_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0002249 ! RUVB1_HUMAN relationship: has_participant CCO:B0002250 ! NUDC_HUMAN relationship: has_participant CCO:B0002252 ! SUGT1_HUMAN relationship: has_participant CCO:B0002257 ! CD2AP_HUMAN relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0026257 ! PDS5B_HUMAN relationship: has_participant CCO:B0032821 ! ZWILC_HUMAN relationship: has_participant CCO:B0035936 ! RNF8_HUMAN relationship: has_participant CCO:B0035938 ! SETD8_HUMAN relationship: has_participant CCO:B0039949 ! FSD1_HUMAN relationship: has_participant CCO:B0041228 ! B1AK43_HUMAN relationship: has_participant CCO:B0041229 ! B1AK44_HUMAN relationship: has_participant CCO:B0041230 ! B1AK45_HUMAN relationship: has_participant CCO:B0041231 ! B1AK46_HUMAN relationship: has_participant CCO:B0041232 ! B1AK47_HUMAN relationship: has_participant CCO:B0041237 ! B1AQT3_HUMAN relationship: has_participant CCO:B0041238 ! B1AQT4_HUMAN relationship: has_participant CCO:B0041249 ! HMGA2_HUMAN relationship: has_participant CCO:B0041256 ! ERC6L_HUMAN relationship: has_participant CCO:B0041257 ! E4F1_HUMAN relationship: part_of CCO:P0000017 ! M phase of mitotic cell cycle [Term] id: CCO:P0000082 name: negative regulation of transcription, mitotic namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] synonym: "down regulation of transcription, mitotic" EXACT [] synonym: "down-regulation of transcription, mitotic" EXACT [] synonym: "downregulation of transcription, mitotic" EXACT [] synonym: "inhibition of transcription, mitotic" NARROW [] synonym: "mitotic repression of transcription" EXACT [] xref: GO:0007068 is_a: CCO:P0000256 ! regulation of transcription, mitotic [Term] id: CCO:P0000083 name: negative regulation of transcription from RNA polymerase I promoter, mitotic namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] synonym: "down-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] synonym: "downregulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] synonym: "inhibition of transcription from RNA polymerase I promoter, mitotic" NARROW [] synonym: "mitotic repression of transcription from Pol I promoter" EXACT [] synonym: "negative regulation of transcription from Pol I promoter, mitotic" EXACT [] xref: GO:0007069 is_a: CCO:P0000082 ! negative regulation of transcription, mitotic is_a: CCO:P0000266 ! regulation of transcription from RNA polymerase I promoter, mitotic [Term] id: CCO:P0000084 name: negative regulation of transcription from RNA polymerase II promoter, mitotic namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter, mitotic" NARROW [] synonym: "mitotic repression of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from Pol II promoter, mitotic" EXACT [] xref: GO:0007070 is_a: CCO:P0000082 ! negative regulation of transcription, mitotic is_a: CCO:P0000268 ! regulation of transcription from RNA polymerase II promoter, mitotic [Term] id: CCO:P0000085 name: negative regulation of transcription from RNA polymerase III promoter, mitotic namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] synonym: "down-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] synonym: "downregulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] synonym: "inhibition of transcription from RNA polymerase III promoter, mitotic" NARROW [] synonym: "mitotic repression of transcription from Pol III promoter" EXACT [] synonym: "negative regulation of transcription from Pol III promoter, mitotic" EXACT [] xref: GO:0007071 is_a: CCO:P0000082 ! negative regulation of transcription, mitotic is_a: CCO:P0000270 ! regulation of transcription from RNA polymerase III promoter, mitotic [Term] id: CCO:P0000086 name: positive regulation of transcription on exit from mitosis namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb] xref: GO:0007072 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000152 ! exit from mitosis [Term] id: CCO:P0000087 name: positive regulation of transcription on exit from mitosis, from RNA polymerase I promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW [] xref: GO:0007073 is_a: CCO:P0000086 ! positive regulation of transcription on exit from mitosis [Term] id: CCO:P0000088 name: positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW [] xref: GO:0007074 is_a: CCO:P0000086 ! positive regulation of transcription on exit from mitosis [Term] id: CCO:P0000089 name: positive regulation of transcription on exit from mitosis, from RNA polymerase III promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb] xref: GO:0007075 is_a: CCO:P0000086 ! positive regulation of transcription on exit from mitosis [Term] id: CCO:P0000090 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] xref: GO:0007076 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001400 ! O43832_HUMAN relationship: has_participant CCO:B0001450 ! SMC2_HUMAN relationship: has_participant CCO:B0001481 ! HSP1_HUMAN relationship: has_participant CCO:B0001482 ! PRM2_HUMAN relationship: has_participant CCO:B0001614 ! CNDD3_HUMAN relationship: has_participant CCO:B0001797 ! CND2_HUMAN relationship: has_participant CCO:B0001801 ! CND1_HUMAN relationship: has_participant CCO:B0001902 ! POLS_HUMAN relationship: has_participant CCO:B0001943 ! CNDG2_HUMAN relationship: has_participant CCO:B0002038 ! CDCA5_HUMAN relationship: has_participant CCO:B0002092 ! CND3_HUMAN relationship: has_participant CCO:B0002108 ! NUSAP_HUMAN relationship: has_participant CCO:B0002148 ! CHM1A_HUMAN relationship: has_participant CCO:B0002149 ! PRM3_HUMAN relationship: has_participant CCO:B0002168 ! SMC4_HUMAN relationship: has_participant CCO:B0041259 ! CNDH2_HUMAN relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000091 name: mitotic nuclear envelope disassembly namespace: biological_process def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf] synonym: "mitotic nuclear envelope breakdown" EXACT [] synonym: "mitotic nuclear envelope catabolism" EXACT [] synonym: "mitotic nuclear envelope degradation" EXACT [] xref: GO:0007077 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000092 name: lamin depolymerization namespace: biological_process def: "The cell cycle process whereby lamin is depolymerized." [GOC:jic] xref: GO:0007078 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000091 ! mitotic nuclear envelope disassembly [Term] id: CCO:P0000093 name: mitotic chromosome movement towards spindle pole namespace: biological_process def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai] synonym: "chromosome migration to spindle pole during mitosis" EXACT [] synonym: "chromosome movement towards spindle pole during mitosis" EXACT [] synonym: "mitotic chromosome movement" BROAD [] synonym: "mitotic chromosome movement to spindle pole" EXACT [] synonym: "mitotic sister chromosome movement towards spindle pole" EXACT [] synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT [] xref: GO:0007079 xref: GO:0007082 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001715 ! CENPE_HUMAN relationship: has_participant CCO:B0001807 ! DLG7_HUMAN relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000094 name: mitotic metaphase plate congression namespace: biological_process def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194] xref: GO:0007080 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001715 ! CENPE_HUMAN relationship: has_participant CCO:B0002038 ! CDCA5_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000095 name: mitotic chromosome decondensation namespace: biological_process def: "The cell cycle process whereby chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai] xref: GO:0007083 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000096 name: mitotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process whereby the nuclear envelope reforms during mitotic cell division." [GOC:ai] xref: GO:0007084 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000097 name: vesicle fusion with nuclear membrane namespace: biological_process def: "The cell cycle process whereby the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus occurs." [GOC:jic] xref: GO:0007086 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000096 ! mitotic nuclear envelope reassembly [Term] id: CCO:P0000098 name: mitotic nuclear pore complex reassembly namespace: biological_process def: "The cell cycle process whereby nuclear pore complexes reform during mitotic cell division." [GOC:ai] xref: GO:0007087 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000096 ! mitotic nuclear envelope reassembly [Term] id: CCO:P0000099 name: regulation of mitosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] xref: GO:0007088 is_a: CCO:P0000138 ! regulation of mitotic cell cycle is_a: CCO:P0000382 ! regulation of cell cycle process relationship: has_participant CCO:B0001357 ! ANM5_HUMAN relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0001578 ! MPIP3_HUMAN relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001739 ! CDC16_HUMAN relationship: has_participant CCO:B0001755 ! PIN1_HUMAN relationship: has_participant CCO:B0001771 ! CD2L5_HUMAN relationship: has_participant CCO:B0002056 ! MPPH1_HUMAN relationship: has_participant CCO:B0002078 ! PMYT1_HUMAN relationship: regulates CCO:P0000081 ! mitosis [Term] id: CCO:P0000100 name: traversing start control point of mitotic cell cycle namespace: biological_process def: "Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle." [GOC:mah, ISBN:0815316194] synonym: "G1 checkpoint" RELATED [] xref: GO:0000081 xref: GO:0007089 is_a: CCO:P0000138 ! regulation of mitotic cell cycle relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001555 ! CDK2_HUMAN relationship: has_participant CCO:B0001578 ! MPIP3_HUMAN relationship: has_participant CCO:B0001803 ! CDK10_HUMAN relationship: has_participant CCO:B0002087 ! CDC6_HUMAN relationship: part_of CCO:P0000011 ! G1 phase of mitotic cell cycle [Term] id: CCO:P0000101 name: regulation of S phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators] xref: GO:0007090 is_a: CCO:P0000215 ! regulation of S phase relationship: has_participant CCO:B0001533 ! RCC1_HUMAN relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: part_of CCO:P0000138 ! regulation of mitotic cell cycle relationship: regulates CCO:P0000014 ! S phase of mitotic cell cycle [Term] id: CCO:P0000102 name: mitotic metaphase/anaphase transition namespace: biological_process def: "The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins." [PMID:10465783] xref: GO:0007091 xref: Reactome:211778 xref: Reactome:221543 xref: Reactome:230154 xref: Reactome:238183 xref: Reactome:68881 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001572 ! CDC27_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: part_of CCO:P0000081 ! mitosis [Term] id: CCO:P0000103 name: activation of anaphase-promoting complex during mitotic cell cycle namespace: biological_process def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex during the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297] synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during mitotic cell cycle" EXACT [] synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during mitotic cell cycle" EXACT [] synonym: "activation of ubiquitin ligase activity of APC during mitotic cell cycle" EXACT [] synonym: "anaphase promoting complex activation during mitotic cell cycle" EXACT [] synonym: "anaphase-promoting complex activation during mitotic cell cycle" EXACT [] synonym: "APC activation during mitotic cell cycle" EXACT [] synonym: "mitotic anaphase promoting complex activation" EXACT [] synonym: "mitotic anaphase promoting complex activator" NARROW [] synonym: "mitotic anaphase-promoting complex activation" EXACT [] synonym: "mitotic anaphase-promoting complex activator" NARROW [] synonym: "mitotic APC activation" EXACT [] synonym: "mitotic APC activator" NARROW [] xref: GO:0007092 xref: Reactome:162659 xref: Reactome:163010 xref: Reactome:204411 xref: Reactome:207643 xref: Reactome:213411 xref: Reactome:217136 xref: Reactome:223197 xref: Reactome:225891 xref: Reactome:231660 xref: Reactome:234574 xref: Reactome:239612 xref: Reactome:245838 xref: Reactome:250346 xref: Reactome:253161 xref: Reactome:256356 xref: Reactome:259780 xref: Reactome:265942 xref: Reactome:283716 is_a: CCO:P0000334 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: part_of CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition [Term] id: CCO:P0000104 name: mitotic cell cycle checkpoint namespace: biological_process def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, GOC:rn, PMID:12360190] synonym: "mitotic checkpoint" RELATED [] xref: GO:0007093 is_a: CCO:P0000006 ! cell cycle checkpoint is_a: CCO:P0000138 ! regulation of mitotic cell cycle relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001395 ! BUB1_HUMAN relationship: has_participant CCO:B0001396 ! BUB3_HUMAN relationship: has_participant CCO:B0001411 ! BUB1B_HUMAN relationship: has_participant CCO:B0001441 ! RAD17_HUMAN relationship: has_participant CCO:B0001449 ! ZWINT_HUMAN relationship: has_participant CCO:B0001645 ! KNTC1_HUMAN relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0002035 ! CHFR_HUMAN relationship: has_participant CCO:B0002264 ! MD1L1_HUMAN relationship: has_participant CCO:B0032821 ! ZWILC_HUMAN [Term] id: CCO:P0000105 name: mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly)." [GOC:rn, PMID:12360190] synonym: "Mad2-dependent checkpoint" NARROW [] synonym: "mitotic spindle checkpoint" RELATED [] xref: GO:0007094 xref: Reactome:212060 xref: Reactome:221823 xref: Reactome:230392 xref: Reactome:238432 xref: Reactome:244975 xref: Reactome:252583 xref: Reactome:255764 xref: Reactome:259160 xref: Reactome:262517 xref: Reactome:265345 xref: Reactome:268471 xref: Reactome:274195 xref: Reactome:280667 xref: Reactome:286686 xref: Reactome:69618 is_a: CCO:P0000104 ! mitotic cell cycle checkpoint is_a: CCO:P0000190 ! spindle checkpoint relationship: has_participant CCO:B0001395 ! BUB1_HUMAN relationship: has_participant CCO:B0001396 ! BUB3_HUMAN relationship: has_participant CCO:B0001587 ! TTK_HUMAN relationship: has_participant CCO:B0001629 ! CENPF_HUMAN relationship: has_participant CCO:B0001750 ! ATM_HUMAN relationship: has_participant CCO:B0002204 ! MD2L2_HUMAN [Term] id: CCO:P0000106 name: mitotic cell cycle G2/M transition DNA damage checkpoint namespace: biological_process def: "A signal transduction-based surveillance mechanism that acts during a mitotic cell cycle to ensure accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA." [GOC:mah, PMID:10856933, PMID:11406266] synonym: "mitotic G2 checkpoint" RELATED [] xref: GO:0007095 is_a: CCO:P0000185 ! G2/M transition DNA damage checkpoint relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001538 ! CCNA2_HUMAN [Term] id: CCO:P0000107 name: regulation of exit from mitosis namespace: biological_process def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn] xref: GO:0007096 is_a: CCO:P0000099 ! regulation of mitosis relationship: has_participant CCO:B0001341 ! A6NMP7_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001645 ! KNTC1_HUMAN relationship: has_participant CCO:B0001799 ! MD2BP_HUMAN relationship: has_participant CCO:B0001936 ! NPM2_HUMAN relationship: has_participant CCO:B0001951 ! SIRT2_HUMAN relationship: has_participant CCO:B0002060 ! NEB2_HUMAN relationship: has_participant CCO:B0002155 ! ANLN_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: regulates CCO:P0000152 ! exit from mitosis [Term] id: CCO:P0000108 name: centrosome cycle namespace: biological_process def: "The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] xref: GO:0007098 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001368 ! CETN3_HUMAN relationship: has_participant CCO:B0001495 ! NPM_HUMAN relationship: has_participant CCO:B0002114 ! Q9BYG9_HUMAN relationship: has_participant CCO:B0002211 ! TBE_HUMAN [Term] id: CCO:P0000109 name: centriole replication namespace: biological_process def: "The cell cycle process whereby a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kva, ISBN:0815316194] synonym: "centriole duplication" EXACT [] xref: GO:0007099 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001961 ! CNTRB_HUMAN relationship: part_of CCO:P0000300 ! centrosome duplication [Term] id: CCO:P0000110 name: mitotic centrosome separation namespace: biological_process def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] xref: GO:0007100 is_a: CCO:P0000301 ! centrosome separation relationship: has_participant CCO:B0001731 ! CETN1_HUMAN [Term] id: CCO:P0000111 name: male meiosis centrosome cycle namespace: biological_process def: "Centrosome duplication and separation in the context of male meiosis." [GOC:mah] xref: GO:0007101 is_a: CCO:P0000108 ! centrosome cycle [Term] id: CCO:P0000112 name: spindle pole body duplication in nuclear envelope namespace: biological_process def: "Construction of a new spindle pole body adjacent to the existing spindle pole body in the nuclear envelope; usually occurs about the time of bud emergence." [ISBN:0879693649] synonym: "spindle pole body duplication (sensu Saccharomyces)" EXACT [] xref: GO:0007103 is_a: CCO:P0000164 ! spindle pole body duplication [Term] id: CCO:P0000113 name: cytokinesis after meiosis I namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:ai] xref: GO:0007110 is_a: CCO:P0000213 ! cytokinesis after meiosis [Term] id: CCO:P0000114 name: cytokinesis after meiosis II namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:ai] xref: GO:0007111 is_a: CCO:P0000213 ! cytokinesis after meiosis [Term] id: CCO:P0000115 name: male meiosis cytokinesis namespace: biological_process def: "A cell cycle process that occurs during male meiosis and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] xref: GO:0007112 is_a: CCO:P0000213 ! cytokinesis after meiosis [Term] id: CCO:P0000116 name: endomitotic cell cycle namespace: biological_process def: "A cell cycle in which chromosomes are replicated and sister chromatids separate, but neither spindle formation nor nuclear membrane breakdown, and nuclear division does not occur, resulting in an increased number of chromosomes in the cell." [GOC:expert_vm, http://www.onelook.com] synonym: "endomitosis" EXACT [] xref: GO:0007113 is_a: CCO:P0000066 ! cell cycle [Term] id: CCO:P0000117 name: meiosis namespace: biological_process def: "Progression through meiosis, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiosis occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations." [PMID:9334324] subset: goslim_yeast xref: GO:0007126 is_a: CCO:P0000160 ! cell cycle phase relationship: has_participant CCO:B0001378 ! MSH4_HUMAN relationship: has_participant CCO:B0001381 ! MSH5_HUMAN relationship: has_participant CCO:B0001387 ! ZW10_HUMAN relationship: has_participant CCO:B0001392 ! XRCC2_HUMAN relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001447 ! REC8_HUMAN relationship: has_participant CCO:B0001526 ! H2AX_HUMAN relationship: has_participant CCO:B0001641 ! MRE11_HUMAN relationship: has_participant CCO:B0001654 ! NEK2_HUMAN relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN relationship: has_participant CCO:B0001726 ! DMWD_HUMAN relationship: has_participant CCO:B0001753 ! TOP3A_HUMAN relationship: has_participant CCO:B0001784 ! DMC1_HUMAN relationship: has_participant CCO:B0001790 ! SMC1A_HUMAN relationship: has_participant CCO:B0001808 ! SYCP1_HUMAN relationship: has_participant CCO:B0001835 ! FBX43_HUMAN relationship: has_participant CCO:B0001882 ! UT14C_HUMAN relationship: has_participant CCO:B0001907 ! WBP2L_HUMAN relationship: has_participant CCO:B0001915 ! SYCE2_HUMAN relationship: has_participant CCO:B0001923 ! Q6ZNA8_HUMAN relationship: has_participant CCO:B0001957 ! SYCP3_HUMAN relationship: has_participant CCO:B0001960 ! SYCE1_HUMAN relationship: has_participant CCO:B0001962 ! STAG2_HUMAN relationship: has_participant CCO:B0001972 ! BOLL_HUMAN relationship: has_participant CCO:B0001977 ! SMC1B_HUMAN relationship: has_participant CCO:B0001979 ! MNS1_HUMAN relationship: has_participant CCO:B0002007 ! CCNB3_HUMAN relationship: has_participant CCO:B0002012 ! RSPH1_HUMAN relationship: has_participant CCO:B0002016 ! RAD54_HUMAN relationship: has_participant CCO:B0002021 ! RAD50_HUMAN relationship: has_participant CCO:B0002106 ! SYCP2_HUMAN relationship: has_participant CCO:B0002207 ! DUS13_HUMAN relationship: has_participant CCO:B0002209 ! STAG3_HUMAN relationship: has_participant CCO:B0002240 ! EXO1_HUMAN relationship: has_participant CCO:B0002243 ! SMC3_HUMAN relationship: has_participant CCO:B0002246 ! OSGI2_HUMAN relationship: has_participant CCO:B0002255 ! RBM7_HUMAN relationship: has_participant CCO:B0002256 ! SPO11_HUMAN relationship: has_participant CCO:B0026255 ! KLDC3_HUMAN relationship: has_participant CCO:B0032571 ! HOP2_HUMAN relationship: has_participant CCO:B0032820 ! ZN318_HUMAN relationship: has_participant CCO:B0032873 ! MND1_HUMAN relationship: has_participant CCO:B0035937 ! S26A8_HUMAN relationship: has_participant CCO:B0039947 ! STRA8_HUMAN relationship: has_participant CCO:B0039948 ! ZFP42_HUMAN relationship: part_of CCO:P0000322 ! M phase of meiotic cell cycle [Term] id: CCO:P0000118 name: meiosis I namespace: biological_process def: "Progression through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [PMID:9334324] xref: GO:0007127 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000117 ! meiosis [Term] id: CCO:P0000119 name: meiotic prophase I namespace: biological_process def: "Progression through prophase of meiosis I; divided into several stages." [GOC:mah] xref: GO:0007128 is_a: CCO:P0000319 ! prophase relationship: has_participant CCO:B0001413 ! RAD1_HUMAN relationship: has_participant CCO:B0001915 ! SYCE2_HUMAN relationship: has_participant CCO:B0001960 ! SYCE1_HUMAN relationship: has_participant CCO:B0002106 ! SYCP2_HUMAN relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000120 name: synapsis namespace: biological_process def: "The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate." [GOC:elh] synonym: "homologous chromosome pairing at meiosis" EXACT [] xref: GO:0007129 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000121 name: synaptonemal complex assembly namespace: biological_process def: "The cell cycle process whereby the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "synaptonemal complex formation" EXACT [] xref: GO:0007130 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001808 ! SYCP1_HUMAN relationship: has_participant CCO:B0001900 ! Q5VXJ5_HUMAN relationship: has_participant CCO:B0002018 ! SC65_HUMAN relationship: has_participant CCO:B0002106 ! SYCP2_HUMAN relationship: has_participant CCO:B0002209 ! STAG3_HUMAN relationship: part_of CCO:P0000120 ! synapsis [Term] id: CCO:P0000122 name: meiotic recombination namespace: biological_process def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] synonym: "female meiotic recombination" NARROW [] synonym: "gene conversion with reciprocal crossover" EXACT [] xref: GO:0000021 xref: GO:0007131 xref: GO:0007145 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001337 ! A6NLT8_HUMAN relationship: has_participant CCO:B0001359 ! CHK1_HUMAN relationship: has_participant CCO:B0001373 ! RA51B_HUMAN relationship: has_participant CCO:B0001378 ! MSH4_HUMAN relationship: has_participant CCO:B0001381 ! MSH5_HUMAN relationship: has_participant CCO:B0001403 ! RAD21_HUMAN relationship: has_participant CCO:B0001434 ! RA51D_HUMAN relationship: has_participant CCO:B0001447 ! REC8_HUMAN relationship: has_participant CCO:B0001621 ! RAD52_HUMAN relationship: has_participant CCO:B0001638 ! DNL3_HUMAN relationship: has_participant CCO:B0001641 ! MRE11_HUMAN relationship: has_participant CCO:B0001721 ! RAD51_HUMAN relationship: has_participant CCO:B0001750 ! ATM_HUMAN relationship: has_participant CCO:B0001784 ! DMC1_HUMAN relationship: has_participant CCO:B0001808 ! SYCP1_HUMAN relationship: has_participant CCO:B0001886 ! Q5TCH6_HUMAN relationship: has_participant CCO:B0001887 ! Q5TCH7_HUMAN relationship: has_participant CCO:B0002021 ! RAD50_HUMAN relationship: has_participant CCO:B0002200 ! MLH3_HUMAN relationship: has_participant CCO:B0002256 ! SPO11_HUMAN relationship: has_participant CCO:B0002260 ! RA54B_HUMAN relationship: has_participant CCO:B0026255 ! KLDC3_HUMAN relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000123 name: meiotic metaphase I namespace: biological_process def: "Progression through metaphase of meiosis I; analogous to mitotic metaphase." [GOC:mah] xref: GO:0007132 is_a: CCO:P0000318 ! metaphase relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000124 name: meiotic anaphase I namespace: biological_process def: "Progression through anaphase of meiosis I; analogous to mitotic anaphase." [GOC:mah] xref: GO:0007133 is_a: CCO:P0000317 ! anaphase relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000125 name: meiotic telophase I namespace: biological_process def: "Progression through telophase of meiosis I; analogous to mitotic telophase." [GOC:mah] xref: GO:0007134 is_a: CCO:P0000321 ! telophase relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000126 name: meiosis II namespace: biological_process def: "Progression through the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [ISBN:0198547684] xref: GO:0007135 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000117 ! meiosis [Term] id: CCO:P0000127 name: meiotic prophase II namespace: biological_process def: "Progression through prophase of meiosis II; analogous to mitotic prophase." [GOC:mah] xref: GO:0007136 is_a: CCO:P0000319 ! prophase relationship: has_participant CCO:B0001381 ! MSH5_HUMAN relationship: part_of CCO:P0000126 ! meiosis II [Term] id: CCO:P0000128 name: meiotic metaphase II namespace: biological_process def: "Progression through metaphase of meiosis II; analogous to mitotic metaphase." [GOC:mah] xref: GO:0007137 is_a: CCO:P0000318 ! metaphase relationship: part_of CCO:P0000126 ! meiosis II [Term] id: CCO:P0000129 name: meiotic anaphase II namespace: biological_process def: "Progression through anaphase of meiosis II; analogous to mitotic anaphase." [GOC:mah] xref: GO:0007138 is_a: CCO:P0000317 ! anaphase relationship: part_of CCO:P0000126 ! meiosis II [Term] id: CCO:P0000130 name: meiotic telophase II namespace: biological_process def: "Progression through telophase of meiosis II; analogous to mitotic telophase." [GOC:mah] xref: GO:0007139 is_a: CCO:P0000321 ! telophase relationship: part_of CCO:P0000126 ! meiosis II [Term] id: CCO:P0000131 name: male meiosis namespace: biological_process def: "Meiosis in the male germline." [GOC:mah] xref: GO:0007140 is_a: CCO:P0000117 ! meiosis relationship: has_participant CCO:B0001670 ! HSP72_HUMAN relationship: has_participant CCO:B0001959 ! TAF1L_HUMAN relationship: has_participant CCO:B0002185 ! PIM2_HUMAN [Term] id: CCO:P0000132 name: male meiosis I namespace: biological_process def: "Progression through male meiosis I, the first meiotic division in the male germline." [GOC:mah] xref: GO:0007141 is_a: CCO:P0000160 ! cell cycle phase relationship: has_participant CCO:B0001701 ! CCNA1_HUMAN relationship: has_participant CCO:B0001957 ! SYCP3_HUMAN relationship: part_of CCO:P0000131 ! male meiosis [Term] id: CCO:P0000133 name: male meiosis II namespace: biological_process def: "Progression through male meiosis II, the second meiotic division in the male germline." [GOC:mah] xref: GO:0007142 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000131 ! male meiosis [Term] id: CCO:P0000134 name: female meiosis namespace: biological_process def: "Meiosis in the female germline." [GOC:ems] comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaprodites such as those of C. elegans. See also the biological process term 'meiosis ; GO:0007126'. xref: GO:0007143 is_a: CCO:P0000117 ! meiosis relationship: has_participant CCO:B0001362 ! EREG_HUMAN [Term] id: CCO:P0000135 name: female meiosis I namespace: biological_process def: "The cell cycle process whereby the first meiotic division occurs in the female germline." [GOC:mah] xref: GO:0007144 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000134 ! female meiosis [Term] id: CCO:P0000136 name: meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324] xref: GO:0007146 is_a: CCO:P0000045 ! meiotic DNA recombinase assembly [Term] id: CCO:P0000137 name: female meiosis II namespace: biological_process def: "The cell cycle process whereby the second meiotic division occurs in the female germline." [GOC:mah] xref: GO:0007147 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000134 ! female meiosis [Term] id: CCO:P0000138 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of mitotic cell cycle progression" EXACT [] synonym: "mitotic cell cycle control" EXACT [] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: GO:0007346 is_a: CCO:P0000346 ! regulation of cell cycle relationship: has_participant CCO:B0001435 ! CD123_HUMAN relationship: has_participant CCO:B0001680 ! SN1L1_HUMAN relationship: has_participant CCO:B0001964 ! AF1L2_HUMAN relationship: has_participant CCO:B0002221 ! FBX5_HUMAN relationship: regulates CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000139 name: regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "preblastoderm mitotic cell cycle control" EXACT [] synonym: "preblastoderm mitotic cell cycle modulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulator" RELATED [] synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: GO:0007347 is_a: CCO:P0000145 ! regulation of mitotic cell cycle, embryonic relationship: regulates CCO:P0000223 ! preblastoderm mitotic cell cycle [Term] id: CCO:P0000140 name: regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of syncytial blastoderm cell cycle progression" EXACT [] synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of syncytial blastoderm cell cycle" EXACT [] synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "syncytial blastoderm cell cycle control" EXACT [] synonym: "syncytial blastoderm cell cycle modulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulator" RELATED [] xref: GO:0007348 is_a: CCO:P0000145 ! regulation of mitotic cell cycle, embryonic is_a: CCO:P0000159 ! cell cycle process relationship: regulates CCO:P0000224 ! syncytial blastoderm mitotic cell cycle [Term] id: CCO:P0000141 name: cyclin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions." [GOC:mah, http://cancerweb.ncl.ac.uk/] synonym: "cyclin breakdown" EXACT [] synonym: "cyclin catabolism" EXACT [] synonym: "cyclin degradation" EXACT [] synonym: "degradation of cyclin" EXACT [] xref: GO:0008054 is_a: CCO:P0000346 ! regulation of cell cycle relationship: has_participant CCO:B0001354 ! UBE2C_HUMAN relationship: has_participant CCO:B0002216 ! ANC2_HUMAN [Term] id: CCO:P0000142 name: meiotic G2/MI transition namespace: biological_process def: "The cell cycle process whereby a cell progresses from meiotic prophase to metaphase I." [PMID:15088480] xref: GO:0008315 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000143 name: megasporogenesis namespace: biological_process def: "The process by which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb] synonym: "megaspore development" EXACT [] synonym: "megaspore mother cell meiosis" EXACT [] synonym: "meiosis of the megasporocyte" EXACT [] synonym: "meiotic division of the megasporocyte" EXACT [] xref: GO:0009554 is_a: CCO:P0000362 ! plant-type spore development [Term] id: CCO:P0000144 name: microsporogenesis namespace: biological_process def: "The process by which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb] synonym: "microspore development" EXACT systematic_synonym [] xref: GO:0009556 is_a: CCO:P0000362 ! plant-type spore development [Term] id: CCO:P0000145 name: regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of embryonic mitotic cell cycle progression" EXACT [] synonym: "embryonic mitotic cell cycle control" EXACT [] synonym: "embryonic mitotic cell cycle modulation" EXACT [] synonym: "embryonic mitotic cell cycle regulation" EXACT [] synonym: "embryonic mitotic cell cycle regulator" RELATED [] synonym: "modulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT [] xref: GO:0009794 is_a: CCO:P0000138 ! regulation of mitotic cell cycle relationship: regulates CCO:P0000241 ! mitotic cell cycle, embryonic [Term] id: CCO:P0000146 name: cell plate formation involved in plant-type cell wall biogenesis namespace: biological_process def: "The cell cycle process whereby the cell plate is formed at the equator of the spindle in the dividing cells during early telophase." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322] synonym: "cell plate formation (sensu Magnoliophyta)" RELATED [] synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT [] xref: GO:0009920 is_a: CCO:P0000061 ! cell plate formation is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000081 ! mitosis [Term] id: CCO:P0000147 name: anastral spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272] synonym: "male meiotic spindle assembly (sensu Viridiplantae)" EXACT [] xref: GO:0009971 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000131 ! male meiosis [Term] id: CCO:P0000148 name: zygote asymmetric cytokinesis in the embryo sac namespace: biological_process def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429] synonym: "zygote asymmetric cytokinesis (sensu Magnoliophyta)" EXACT [] xref: GO:0010069 is_a: CCO:P0000212 ! cytokinesis during cell cycle [Term] id: CCO:P0000149 name: guard mother cell cytokinesis namespace: biological_process def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb] synonym: "guard mother cell division" EXACT [] xref: GO:0010235 is_a: CCO:P0000055 ! cytokinesis by cell plate formation [Term] id: CCO:P0000150 name: regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [PMID:17329565] xref: GO:0010389 is_a: CCO:P0000138 ! regulation of mitotic cell cycle is_a: CCO:P0000382 ! regulation of cell cycle process relationship: regulates CCO:P0000016 ! G2/M transition of mitotic cell cycle [Term] id: CCO:P0000151 name: meristemoid mother cell division namespace: biological_process def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb] synonym: "meristemoid division" RELATED [] xref: GO:0010443 is_a: CCO:P0000055 ! cytokinesis by cell plate formation [Term] id: CCO:P0000152 name: exit from mitosis namespace: biological_process def: "The cell cycle process where a cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] xref: GO:0010458 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001933 ! CLAP1_HUMAN relationship: part_of CCO:P0000017 ! M phase of mitotic cell cycle [Term] id: CCO:P0000153 name: female meiosis chromosome segregation namespace: biological_process def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] xref: GO:0016321 is_a: CCO:P0000159 ! cell cycle process is_a: CCO:P0000237 ! meiotic chromosome segregation relationship: part_of CCO:P0000134 ! female meiosis [Term] id: CCO:P0000154 name: second mitotic wave during compound eye morphogenesis namespace: biological_process def: "A discrete cell cycle that occurs during the third instar eye imaginal disc after progression of the morphogenetic furrow. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] synonym: "second mitotic wave (sensu Endopterygota)" EXACT [] xref: GO:0016330 is_a: CCO:P0000066 ! cell cycle [Term] id: CCO:P0000155 name: meiotic chromosome movement towards spindle pole namespace: biological_process def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai] synonym: "chromosome migration to spindle pole during meiosis" EXACT [] synonym: "chromosome movement towards spindle pole during meiosis" EXACT [] synonym: "meiotic chromosome movement" BROAD [] synonym: "meiotic chromosome movement to spindle pole" EXACT [] xref: GO:0016344 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000156 name: female meiotic chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai] synonym: "chromosome movement towards spindle pole during female meiosis" EXACT [] synonym: "female meiotic chromosome movement" BROAD [] synonym: "female meiotic chromosome movement to spindle pole" EXACT [] xref: GO:0016345 is_a: CCO:P0000155 ! meiotic chromosome movement towards spindle pole relationship: part_of CCO:P0000153 ! female meiosis chromosome segregation [Term] id: CCO:P0000157 name: male meiotic chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai] synonym: "chromosome movement towards spindle pole during male meiosis" EXACT [] synonym: "male meiotic chromosome movement" BROAD [] synonym: "male meiotic chromosome movement to spindle pole" EXACT [] xref: GO:0016346 is_a: CCO:P0000155 ! meiotic chromosome movement towards spindle pole relationship: part_of CCO:P0000075 ! male meiosis chromosome segregation [Term] id: CCO:P0000158 name: cell cycle arrest of committed forebrain neuronal progenitor cell namespace: biological_process def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:16226447] comment: This term was added by GO_REF:0000021. xref: GO:0021883 is_a: CCO:P0000067 ! cell cycle arrest [Term] id: CCO:P0000159 name: cell cycle process namespace: biological_process def: "A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:isa_complete] subset: gosubset_prok xref: GO:0022402 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000066 ! cell cycle [Term] id: CCO:P0000160 name: cell cycle phase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events." [GOC:isa_complete] xref: GO:0022403 is_a: CCO:P0000159 ! cell cycle process [Term] id: CCO:P0000161 name: actin filament reorganization during cell cycle namespace: biological_process def: "The cell cycle process whereby rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah] synonym: "actin filament reorganisation during cell cycle" EXACT [] xref: GO:0030037 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0002052 ! CEND2_HUMAN [Term] id: CCO:P0000162 name: regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah] xref: GO:0030071 is_a: CCO:P0000099 ! regulation of mitosis relationship: has_participant CCO:B0001380 ! ZZEF1_HUMAN relationship: has_participant CCO:B0001875 ! HECD3_HUMAN relationship: has_participant CCO:B0001888 ! Q5TCY3_HUMAN relationship: has_participant CCO:B0001949 ! PARC_HUMAN relationship: has_participant CCO:B0002145 ! NEK6_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0002230 ! APC10_HUMAN relationship: has_participant CCO:B0019420 ! Q53FN2_HUMAN relationship: regulates CCO:P0000102 ! mitotic metaphase/anaphase transition [Term] id: CCO:P0000163 name: mitotic spindle organization and biogenesis in nucleus namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus during a mitotic cell cycle, as seen in Fungi." [GOC:mah] synonym: "mitotic spindle assembly (sensu Fungi)" NARROW [] synonym: "mitotic spindle assembly (sensu Saccharomyces)" NARROW [] synonym: "mitotic spindle organisation and biogenesis in nucleus" EXACT [] synonym: "spindle organization and biogenesis in nucleus during mitosis" EXACT [] xref: GO:0000071 xref: GO:0030472 is_a: CCO:P0000068 ! mitotic spindle organization and biogenesis [Term] id: CCO:P0000164 name: spindle pole body duplication namespace: biological_process def: "Construction of a new spindle pole body." [GOC:clt] synonym: "spindle pole body assembly" EXACT [] synonym: "spindle pole body biogenesis" EXACT [] synonym: "spindle pole body biosynthesis" EXACT [] synonym: "spindle pole body duplication (sensu Fungi)" EXACT [] synonym: "spindle pole body formation" EXACT [] synonym: "spindle pole body replication" EXACT [] xref: GO:0030474 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000302 ! spindle pole body organization and biogenesis [Term] id: CCO:P0000165 name: horsetail nuclear movement namespace: biological_process def: "The cell cycle process whereby oscillatory movement of the nucleus during meiotic prophase I occurs. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, which may facilitate synapsis necessary for efficient meiotic recombination; as observed in S. pombe." [PMID:16111942, PMID:9572142] synonym: "HNM" EXACT [] synonym: "horsetail movement" EXACT [] xref: GO:0030989 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000117 ! meiosis [Term] id: CCO:P0000166 name: cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:tb, GOC:vw] xref: GO:0030996 is_a: CCO:P0000067 ! cell cycle arrest [Term] id: CCO:P0000167 name: regulation of centriole-centriole cohesion namespace: biological_process def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968] xref: GO:0030997 is_a: CCO:U0000002 ! biological process relationship: has_participant CCO:B0002099 ! CP250_HUMAN relationship: part_of CCO:P0000108 ! centrosome cycle [Term] id: CCO:P0000168 name: linear element formation namespace: biological_process def: "The cell cycle process whereby a proteinaceous scaffold, related to the synaptonemal complex, is formed in association with S. pombe chromosomes during meiotic prophase." [GOC:mah, Sanger:jb "Jurg Bahler"] xref: GO:0030999 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000120 ! synapsis [Term] id: CCO:P0000169 name: septation initiation signaling namespace: biological_process def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the begining of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007] synonym: "septation initiation network" EXACT [] synonym: "septation initiation signalling" EXACT [] synonym: "SIN" EXACT [] xref: GO:0031028 is_a: CCO:P0000107 ! regulation of exit from mitosis is_a: CCO:P0000199 ! regulation of contractile ring contraction involved in cytokinesis [Term] id: CCO:P0000170 name: regulation of septation initiation signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "regulation of septation initiation network" EXACT [] synonym: "regulation of septation initiation signalling" EXACT [] xref: GO:0031029 is_a: CCO:U0000002 ! biological process relationship: regulates CCO:P0000169 ! septation initiation signaling [Term] id: CCO:P0000171 name: negative regulation of septation initiation signaling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "down regulation of septation initiation signaling" EXACT [] synonym: "down-regulation of septation initiation signaling" EXACT [] synonym: "downregulation of septation initiation signaling" EXACT [] synonym: "inhibition of septation initiation signaling" NARROW [] synonym: "negative regulation of septation initiation network" EXACT [] synonym: "negative regulation of septation initiation signalling" EXACT [] xref: GO:0031030 is_a: CCO:P0000170 ! regulation of septation initiation signaling relationship: negatively_regulates CCO:P0000169 ! septation initiation signaling [Term] id: CCO:P0000172 name: positive regulation of septation initiation signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "activation of septation initiation signaling" NARROW [] synonym: "positive regulation of septation initiation network" EXACT [] synonym: "positive regulation of septation initiation signalling" EXACT [] synonym: "stimulation of septation initiation signaling" NARROW [] synonym: "up regulation of septation initiation signaling" EXACT [] synonym: "up-regulation of septation initiation signaling" EXACT [] synonym: "upregulation of septation initiation signaling" EXACT [] xref: GO:0031031 is_a: CCO:P0000170 ! regulation of septation initiation signaling relationship: positively_regulates CCO:P0000169 ! septation initiation signaling [Term] id: CCO:P0000173 name: spindle pole body duplication in cytoplasm namespace: biological_process def: "Construction of a new spindle pole body adjacent to the existing spindle pole body exterior to the outer nuclear envelope." [GOC:clt] synonym: "spindle pole body duplication (sensu Schizosaccharomyces)" EXACT [] xref: GO:0031046 is_a: CCO:P0000164 ! spindle pole body duplication [Term] id: CCO:P0000174 name: sister chromatid biorientation namespace: biological_process def: "The cell cycle process whereby sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047] synonym: "chromosome biorientation" EXACT [] synonym: "sister kinetochore biorientation" EXACT [] xref: GO:0031134 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000094 ! mitotic metaphase plate congression [Term] id: CCO:P0000176 name: ascospore-type prospore-specific spindle pole body modification namespace: biological_process def: "Structural modification of the spindle pole body that takes place during the second meiotic division during ascospore formation; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385] synonym: "forespore specific spindle pole body modification" EXACT [] synonym: "forespore-specific spindle pole body modification" EXACT [] synonym: "prospore specific spindle pole body modification" EXACT [] synonym: "sporulation specific spindle pole body modification " EXACT [] xref: GO:0031322 is_a: CCO:P0000302 ! spindle pole body organization and biogenesis [Term] id: CCO:P0000177 name: positive regulation of exit from mitosis namespace: biological_process def: "Any processactivates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah] synonym: "activation of exit from mitosis" NARROW [] synonym: "stimulation of exit from mitosis" NARROW [] synonym: "up regulation of exit from mitosis" EXACT [] synonym: "up-regulation of exit from mitosis" EXACT [] synonym: "upregulation of exit from mitosis" EXACT [] xref: GO:0031536 is_a: CCO:P0000107 ! regulation of exit from mitosis is_a: CCO:P0000251 ! positive regulation of mitosis relationship: has_participant CCO:B0001354 ! UBE2C_HUMAN relationship: has_participant CCO:B0001377 ! BIRC5_HUMAN relationship: positively_regulates CCO:P0000152 ! exit from mitosis [Term] id: CCO:P0000178 name: cytokinesis checkpoint namespace: biological_process def: "A cell cycle checkpoint that ensures the correct temporal ordering of nuclear division and cytokinesis; arrests the cell cycle in G2 upon perturbation of cytokinetic structures. In Schizosaccharomyces, the checkpoint monitors formation and integrity of medial actomyosin ring and septum." [GOC:mah, PMID:15647375] synonym: "contractile ring checkpoint" EXACT [] xref: GO:0031565 is_a: CCO:P0000006 ! cell cycle checkpoint [Term] id: CCO:P0000179 name: contractile ring maintenance involved in cytokinesis namespace: biological_process def: "The cell cycle process whereby the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures." [GOC:dph, GOC:tb, GOC:vw] synonym: "cytokinesis, contractile ring maintenance" EXACT [GOC:dph, GOC:tb] xref: GO:0031566 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000212 ! cytokinesis during cell cycle [Term] id: CCO:P0000180 name: cell size control checkpoint namespace: biological_process def: "Any cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size." [GOC:mah] xref: GO:0031567 is_a: CCO:P0000104 ! mitotic cell cycle checkpoint [Term] id: CCO:P0000181 name: G1/S transition size control checkpoint namespace: biological_process def: "A cell cycle checkpoint that blocks cell cycle progression from G1 to S phase until cells have reached a critical size." [GOC:mah] xref: GO:0031568 is_a: CCO:P0000180 ! cell size control checkpoint is_a: CCO:P0000188 ! G1/S transition checkpoint [Term] id: CCO:P0000182 name: G2/M transition size control checkpoint namespace: biological_process def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until cells have reached a critical size." [GOC:mah] xref: GO:0031569 is_a: CCO:P0000180 ! cell size control checkpoint is_a: CCO:P0000189 ! G2/M transition checkpoint [Term] id: CCO:P0000183 name: DNA integrity checkpoint namespace: biological_process def: "Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure." [GOC:mah, GOC:vw] xref: GO:0031570 is_a: CCO:P0000006 ! cell cycle checkpoint [Term] id: CCO:P0000184 name: G1 DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that arrests cell cycle progression G1 phase in response to DNA damage." [GOC:mah] xref: GO:0031571 is_a: CCO:P0000008 ! DNA damage checkpoint is_a: CCO:P0000188 ! G1/S transition checkpoint [Term] id: CCO:P0000185 name: G2/M transition DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage." [GOC:mah] xref: GO:0031572 is_a: CCO:P0000008 ! DNA damage checkpoint is_a: CCO:P0000189 ! G2/M transition checkpoint relationship: has_participant CCO:B0001909 ! RINT1_HUMAN relationship: has_participant CCO:B0001992 ! BRSK1_HUMAN relationship: has_participant CCO:B0005502 ! BLM_HUMAN [Term] id: CCO:P0000186 name: intra-S DNA damage checkpoint namespace: biological_process def: "The slowing of DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession." [GOC:vw] xref: GO:0031573 is_a: CCO:P0000008 ! DNA damage checkpoint relationship: has_participant CCO:B0001984 ! NEK11_HUMAN relationship: has_participant CCO:B0002104 ! TIPIN_HUMAN [Term] id: CCO:P0000187 name: S-M checkpoint namespace: biological_process def: "A cell cycle checkpoint which halts replication in response to nucleotide depletion." [GOC:vw] xref: GO:0031574 is_a: CCO:P0000008 ! DNA damage checkpoint relationship: has_participant CCO:B0001758 ! ULA1_HUMAN [Term] id: CCO:P0000188 name: G1/S transition checkpoint namespace: biological_process def: "Any cell cycle checkpoint that blocks entry into S phase." [GOC:mah] xref: GO:0031575 is_a: CCO:P0000104 ! mitotic cell cycle checkpoint relationship: has_participant CCO:B0001421 ! NBN_HUMAN relationship: has_participant CCO:B0001736 ! DLG1_HUMAN [Term] id: CCO:P0000189 name: G2/M transition checkpoint namespace: biological_process def: "Any cell cycle checkpoint that blocks entry into M phase." [GOC:mah] synonym: "G2/M checkpoint" EXACT [] xref: GO:0031576 is_a: CCO:P0000104 ! mitotic cell cycle checkpoint [Term] id: CCO:P0000190 name: spindle checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, PMID:15897186] synonym: "SAC" BROAD [] synonym: "spindle assembly checkpoint" EXACT [] xref: GO:0031577 is_a: CCO:P0000006 ! cell cycle checkpoint relationship: has_participant CCO:B0001377 ! BIRC5_HUMAN [Term] id: CCO:P0000191 name: mitotic cell cycle spindle orientation checkpoint namespace: biological_process def: "A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected." [GOC:clt, PMID:14616062] synonym: "SOC" EXACT [] synonym: "spindle position checkpoint" EXACT [] synonym: "SPOC" EXACT [] xref: GO:0031578 is_a: CCO:P0000104 ! mitotic cell cycle checkpoint is_a: CCO:P0000190 ! spindle checkpoint [Term] id: CCO:P0000192 name: homologous chromosome orientation during meiosis namespace: biological_process def: "The cell cycle process whereby the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096] synonym: "homologous chromosome orientation during meiosis I" EXACT [] xref: GO:0031619 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000231 ! meiotic metaphase I plate congression [Term] id: CCO:P0000193 name: G1/S-specific regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah] xref: GO:0031657 is_a: CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: part_of CCO:P0000012 ! G1/S transition of mitotic cell cycle [Term] id: CCO:P0000194 name: G1/S-specific negative regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah] synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] xref: GO:0031658 is_a: CCO:P0000193 ! G1/S-specific regulation of cyclin-dependent protein kinase activity is_a: CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity [Term] id: CCO:P0000195 name: G1/S-specific positive regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah] synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT [] xref: GO:0031659 is_a: CCO:P0000193 ! G1/S-specific regulation of cyclin-dependent protein kinase activity is_a: CCO:P0000243 ! positive regulation of cyclin-dependent protein kinase activity [Term] id: CCO:P0000196 name: G2/M-specific regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah] xref: GO:0031660 is_a: CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity relationship: part_of CCO:P0000016 ! G2/M transition of mitotic cell cycle [Term] id: CCO:P0000197 name: G2/M-specific negative regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah] synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] xref: GO:0031661 is_a: CCO:P0000196 ! G2/M-specific regulation of cyclin-dependent protein kinase activity is_a: CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity [Term] id: CCO:P0000198 name: G2/M-specific positive regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah] synonym: "G2/M-specific activation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G2/M-specific stimulation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G2/M-specific up regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific up-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific upregulation of cyclin-dependent protein kinase activity" EXACT [] xref: GO:0031662 is_a: CCO:P0000196 ! G2/M-specific regulation of cyclin-dependent protein kinase activity is_a: CCO:P0000243 ! positive regulation of cyclin-dependent protein kinase activity [Term] id: CCO:P0000199 name: regulation of contractile ring contraction involved in cytokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis." [GOC:dph, GOC:mah, GOC:tb] xref: GO:0031991 is_a: CCO:P0000346 ! regulation of cell cycle relationship: regulates CCO:P0000060 ! contractile ring contraction involved in cytokinesis [Term] id: CCO:P0000200 name: attachment of telomeres to spindle pole body namespace: biological_process def: "The cell cycle process whereby physical connections are formed between telomeres and the spindle pole body, facilitating bouquet formation." [PMID:16615890] xref: GO:0032121 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000238 ! meiotic telomere clustering [Term] id: CCO:P0000201 name: cellular bud neck septin ring organization namespace: biological_process def: "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck." [GOC:mah] xref: GO:0032186 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000212 ! cytokinesis during cell cycle [Term] id: CCO:P0000202 name: establishment of contractile ring localization namespace: biological_process def: "The process by which a contractile ring is assembled in a specific location." [GOC:mah] xref: GO:0032188 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000059 ! cytokinesis, contractile ring formation [Term] id: CCO:P0000203 name: maintenance of contractile ring localization namespace: biological_process def: "Any process by which a contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah] synonym: "cytokinetic ring anchoring" RELATED [] xref: GO:0032189 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000179 ! contractile ring maintenance involved in cytokinesis [Term] id: CCO:P0000204 name: distributive segregation namespace: biological_process def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart] xref: GO:0032837 is_a: CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000205 name: regulation of spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:mah] xref: GO:0032887 is_a: CCO:P0000382 ! regulation of cell cycle process relationship: regulates CCO:P0000293 ! spindle elongation [Term] id: CCO:P0000206 name: regulation of mitotic spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the mitotic spindle." [GOC:mah] xref: GO:0032888 is_a: CCO:P0000205 ! regulation of spindle elongation relationship: regulates CCO:P0000001 ! mitotic spindle elongation [Term] id: CCO:P0000207 name: dipyrromethane cofactor binding namespace: biological_process def: "Interacting selectively with the dipyrromethane cofactor, 3,8-bis(carboxymethyl)-9-methyl-5,10-dihydrodipyrrin-2,7-dipropionic acid." [ChEBI:30410, GOC:mah] xref: GO:0033035 is_a: CCO:P0000169 ! septation initiation signaling [Term] id: CCO:P0000208 name: regulation of sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] xref: GO:0033045 is_a: CCO:P0000382 ! regulation of cell cycle process relationship: regulates CCO:P0000054 ! sister chromatid segregation [Term] id: CCO:P0000209 name: negative regulation of sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] xref: GO:0033046 is_a: CCO:P0000208 ! regulation of sister chromatid segregation relationship: negatively_regulates CCO:P0000054 ! sister chromatid segregation [Term] id: CCO:P0000210 name: regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] xref: GO:0033047 is_a: CCO:P0000208 ! regulation of sister chromatid segregation relationship: regulates CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000211 name: negative regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] xref: GO:0033048 is_a: CCO:P0000209 ! negative regulation of sister chromatid segregation is_a: CCO:P0000210 ! regulation of mitotic sister chromatid segregation relationship: negatively_regulates CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000212 name: cytokinesis during cell cycle namespace: biological_process def: "Cytokinesis that occurs in the context of cell cycle progression and result in the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] xref: GO:0033205 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN [Term] id: CCO:P0000213 name: cytokinesis after meiosis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mah] xref: GO:0033206 is_a: CCO:P0000212 ! cytokinesis during cell cycle [Term] id: CCO:P0000214 name: DNA replication during S phase namespace: biological_process def: "The process whereby new strands of genomic DNA are synthesized, using parental DNA as a template for DNA-dependent DNA polymerases, during progression through S phase of the cell cycle." [GOC:mah] xref: GO:0033260 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000315 ! S phase [Term] id: CCO:P0000215 name: regulation of S phase namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of progression through S phase" EXACT [GOC:dph, GOC:tb] xref: GO:0033261 xref: MetaCyc:PWY-5043 xref: MetaCyc:SALVADEHYPOX-PWY xref: MetaCyc:SALVPURINE2-PWY is_a: CCO:P0000346 ! regulation of cell cycle is_a: CCO:P0000382 ! regulation of cell cycle process relationship: has_participant CCO:B0001346 ! CDC7_HUMAN relationship: has_participant CCO:B0001499 ! CD45_HUMAN relationship: has_participant CCO:B0002104 ! TIPIN_HUMAN relationship: has_participant CCO:B0002235 ! TIM_HUMAN relationship: regulates CCO:P0000315 ! S phase [Term] id: CCO:P0000216 name: regulation of DNA replication during S phase namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication during progression through S phase of the cell cycle." [GOC:mah] xref: GO:0033262 is_a: CCO:P0000215 ! regulation of S phase relationship: has_participant CCO:B0002104 ! TIPIN_HUMAN relationship: regulates CCO:P0000214 ! DNA replication during S phase [Term] id: CCO:P0000217 name: abortive mitotic cell cycle namespace: biological_process def: "A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy." [GOC:mah, PMID:9573008] comment: Note that this term should be used only for abortive mitotic events that occur normally, e.g. during megakaryocyte differentiation; it should not be used for incomplete mitosis resulting from mutation or other abnormal occurrences. synonym: "abortive mitosis" RELATED [] xref: GO:0033277 is_a: CCO:P0000066 ! cell cycle [Term] id: CCO:P0000218 name: cell cycle comprising mitosis without cytokinesis namespace: biological_process def: "A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N)." [GOC:expert_vm, GOC:mah] comment: Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers. xref: GO:0033301 is_a: CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000219 name: meiotic cell cycle checkpoint namespace: biological_process def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mah] xref: GO:0033313 is_a: CCO:P0000006 ! cell cycle checkpoint [Term] id: CCO:P0000220 name: mitotic cell cycle DNA replication checkpoint namespace: biological_process def: "A signal transduction based surveillance mechanism that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mah] xref: GO:0033314 is_a: CCO:P0000007 ! DNA replication checkpoint is_a: CCO:P0000104 ! mitotic cell cycle checkpoint [Term] id: CCO:P0000221 name: meiotic cell cycle DNA replication checkpoint namespace: biological_process def: "A signal transduction based surveillance mechanism that acts during a meiotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the haploid genome." [GOC:mah] xref: GO:0033315 is_a: CCO:P0000007 ! DNA replication checkpoint is_a: CCO:P0000219 ! meiotic cell cycle checkpoint [Term] id: CCO:P0000222 name: meiotic spindle checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah] xref: GO:0033316 is_a: CCO:P0000190 ! spindle checkpoint [Term] id: CCO:P0000223 name: preblastoderm mitotic cell cycle namespace: biological_process def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238] xref: GO:0035185 is_a: CCO:P0000218 ! cell cycle comprising mitosis without cytokinesis is_a: CCO:P0000241 ! mitotic cell cycle, embryonic [Term] id: CCO:P0000224 name: syncytial blastoderm mitotic cell cycle namespace: biological_process def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] xref: GO:0035186 is_a: CCO:P0000218 ! cell cycle comprising mitosis without cytokinesis is_a: CCO:P0000241 ! mitotic cell cycle, embryonic [Term] id: CCO:P0000225 name: establishment of mitotic spindle localization namespace: biological_process def: "The cell cycle process whereby the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai] synonym: "mitotic spindle positioning" EXACT [] synonym: "mitotic spindle positioning (sensu Fungi)" NARROW [] synonym: "mitotic spindle positioning (sensu Saccharomyces)" NARROW [] synonym: "mitotic spindle positioning and orientation (sensu Saccharomyces)" NARROW [] synonym: "mitotic spindle positioning or orientation" EXACT [] synonym: "mitotic spindle positioning or orientation (sensu Fungi)" NARROW [] synonym: "spindle positioning during mitosis" EXACT [] xref: GO:0018986 xref: GO:0030605 xref: GO:0030606 xref: GO:0030608 xref: GO:0030610 xref: GO:0040001 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001787 ! ESPL1_HUMAN relationship: has_participant CCO:B0002108 ! NUSAP_HUMAN relationship: part_of CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000226 name: regulation of meiosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiosis, the process by which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] xref: GO:0040020 is_a: CCO:P0000339 ! regulation of meiotic cell cycle is_a: CCO:P0000382 ! regulation of cell cycle process relationship: regulates CCO:P0000117 ! meiosis [Term] id: CCO:P0000227 name: polar body extrusion after meiotic divisions namespace: biological_process def: "The cell cycle process whereby two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: GO:0040038 is_a: CCO:P0000213 ! cytokinesis after meiosis relationship: part_of CCO:P0000134 ! female meiosis [Term] id: CCO:P0000228 name: meiotic DNA double-strand break formation namespace: biological_process def: "The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427] xref: GO:0042138 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000063 ! meiotic gene conversion relationship: part_of CCO:P0000122 ! meiotic recombination [Term] id: CCO:P0000229 name: early meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324] xref: GO:0042139 is_a: CCO:P0000136 ! meiotic recombination nodule assembly [Term] id: CCO:P0000230 name: late meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324] xref: GO:0042140 is_a: CCO:P0000136 ! meiotic recombination nodule assembly [Term] id: CCO:P0000231 name: meiotic metaphase I plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666] xref: GO:0043060 is_a: CCO:P0000308 ! meiotic metaphase plate congression relationship: part_of CCO:P0000239 ! homologous chromosome segregation [Term] id: CCO:P0000232 name: meiotic metaphase II plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666] xref: GO:0043061 is_a: CCO:P0000308 ! meiotic metaphase plate congression relationship: part_of CCO:P0000240 ! meiotic sister chromatid segregation [Term] id: CCO:P0000233 name: meiotic spindle stabilization namespace: biological_process def: "The cell cycle process whereby spindle integrity is maintained during M phase of meiosis." [GOC:go_curators] xref: GO:0043147 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000030 ! meiotic spindle organization and biogenesis [Term] id: CCO:P0000234 name: mitotic spindle stabilization namespace: biological_process def: "The cell cycle process whereby spindle integrity is maintained during M phase of mitosis." [GOC:go_curators] xref: GO:0043148 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000068 ! mitotic spindle organization and biogenesis [Term] id: CCO:P0000235 name: G0 to G1 transition namespace: biological_process def: "The transition from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [ISBN:0716731363] xref: GO:0045023 is_a: CCO:P0000041 ! re-entry into mitotic cell cycle relationship: has_participant CCO:B0001366 ! MDM4_HUMAN [Term] id: CCO:P0000236 name: negative regulation of meiotic recombination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of recombination during meiosis." [GOC:ai] synonym: "down regulation of meiotic recombination" EXACT [] synonym: "down-regulation of meiotic recombination" EXACT [] synonym: "downregulation of meiotic recombination" EXACT [] synonym: "inhibition of meiotic recombination" NARROW [] synonym: "suppression of meiotic recombination" EXACT [] xref: GO:0045128 is_a: CCO:P0000248 ! negative regulation of meiosis is_a: CCO:P0000381 ! regulation of meiotic recombination relationship: negatively_regulates CCO:P0000122 ! meiotic recombination [Term] id: CCO:P0000237 name: meiotic chromosome segregation namespace: biological_process def: "The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle." [GOC:ai] xref: GO:0045132 is_a: CCO:U0000002 ! biological process relationship: has_participant CCO:B0001847 ! SGOL1_HUMAN relationship: part_of CCO:P0000117 ! meiosis [Term] id: CCO:P0000238 name: meiotic telomere clustering namespace: biological_process def: "The cell cycle process whereby the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in homologous chromosome pairing and therefore progression through meiosis." [GOC:vw, PMID:10690419] synonym: "bouquet biosynthesis" NARROW [] synonym: "bouquet formation" NARROW [] xref: GO:0045141 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000117 ! meiosis [Term] id: CCO:P0000239 name: homologous chromosome segregation namespace: biological_process def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194] synonym: "meiosis I, chromosome segregation" EXACT [] xref: GO:0007061 xref: GO:0045143 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000118 ! meiosis I relationship: part_of CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000240 name: meiotic sister chromatid segregation namespace: biological_process def: "The cell cycle process whereby sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194] synonym: "meiosis II, chromosome segregation" EXACT [] xref: GO:0045144 is_a: CCO:P0000054 ! sister chromatid segregation relationship: part_of CCO:P0000126 ! meiosis II relationship: part_of CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000241 name: mitotic cell cycle, embryonic namespace: biological_process def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators] xref: GO:0045448 is_a: CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000242 name: negative regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity." [GOC:go_curators] synonym: "CDK inhibitor" RELATED [] synonym: "cyclin-dependent kinase inhibitor" RELATED [] synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "inhibition of cyclin-dependent protein kinase activity" NARROW [] synonym: "negative regulation of CDK activity" EXACT [] xref: GO:0045736 is_a: CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity is_a: CCO:P0000246 ! negative regulation of cell cycle relationship: has_participant CCO:B0001445 ! HEXI1_HUMAN relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0002049 ! HEXI2_HUMAN relationship: has_participant CCO:B0002062 ! CK5P1_HUMAN relationship: has_participant CCO:B0002159 ! LATS2_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN [Term] id: CCO:P0000243 name: positive regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators] synonym: "activation of cyclin-dependent protein kinase activity" NARROW [] synonym: "positive regulation of CDK activity" EXACT [] synonym: "stimulation of cyclin-dependent protein kinase activity" NARROW [] synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT [] xref: GO:0045737 is_a: CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity is_a: CCO:P0000247 ! positive regulation of cell cycle [Term] id: CCO:P0000244 name: negative regulation of S phase of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] synonym: "down regulation of S phase of mitotic cell cycle" EXACT [] synonym: "down-regulation of S phase of mitotic cell cycle" EXACT [] synonym: "downregulation of S phase of mitotic cell cycle" EXACT [] synonym: "inhibition of S phase of mitotic cell cycle" NARROW [] xref: GO:0045749 is_a: CCO:P0000101 ! regulation of S phase of mitotic cell cycle is_a: CCO:P0000258 ! negative regulation of mitotic cell cycle relationship: has_participant CCO:B0001344 ! APBB1_HUMAN relationship: has_participant CCO:B0001603 ! BCL6_HUMAN relationship: has_participant CCO:B0001672 ! GAS1_HUMAN relationship: has_participant CCO:B0001998 ! Q8TEY4_HUMAN relationship: has_participant CCO:B0002020 ! APBB2_HUMAN relationship: has_participant CCO:B0002148 ! CHM1A_HUMAN relationship: has_participant CCO:B0002267 ! MYO16_HUMAN relationship: negatively_regulates CCO:P0000014 ! S phase of mitotic cell cycle [Term] id: CCO:P0000245 name: positive regulation of S phase of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] synonym: "activation of S phase of mitotic cell cycle" NARROW [] synonym: "stimulation of S phase of mitotic cell cycle" NARROW [] synonym: "up regulation of S phase of mitotic cell cycle" EXACT [] synonym: "up-regulation of S phase of mitotic cell cycle" EXACT [] synonym: "upregulation of S phase of mitotic cell cycle" EXACT [] xref: GO:0045750 is_a: CCO:P0000101 ! regulation of S phase of mitotic cell cycle is_a: CCO:P0000259 ! positive regulation of mitotic cell cycle relationship: positively_regulates CCO:P0000014 ! S phase of mitotic cell cycle [Term] id: CCO:P0000246 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] xref: GO:0045786 is_a: CCO:P0000346 ! regulation of cell cycle relationship: has_participant CCO:B0001349 ! BIN1_HUMAN relationship: has_participant CCO:B0001350 ! LHR2A_HUMAN relationship: has_participant CCO:B0001355 ! CDKA1_HUMAN relationship: has_participant CCO:B0001367 ! AXN1_HUMAN relationship: has_participant CCO:B0001371 ! LX15B_HUMAN relationship: has_participant CCO:B0001374 ! P73_HUMAN relationship: has_participant CCO:B0001383 ! KLK10_HUMAN relationship: has_participant CCO:B0001385 ! LEU1_HUMAN relationship: has_participant CCO:B0001386 ! LEU2_HUMAN relationship: has_participant CCO:B0001390 ! MTSS1_HUMAN relationship: has_participant CCO:B0001409 ! DBC1_HUMAN relationship: has_participant CCO:B0001411 ! BUB1B_HUMAN relationship: has_participant CCO:B0001416 ! TRI13_HUMAN relationship: has_participant CCO:B0001432 ! GEMI_HUMAN relationship: has_participant CCO:B0001438 ! TUSC2_HUMAN relationship: has_participant CCO:B0001444 ! SASH1_HUMAN relationship: has_participant CCO:B0001454 ! LATS1_HUMAN relationship: has_participant CCO:B0001455 ! RECK_HUMAN relationship: has_participant CCO:B0001458 ! BCL10_HUMAN relationship: has_participant CCO:B0001462 ! EGFR_HUMAN relationship: has_participant CCO:B0001471 ! TGFB1_HUMAN relationship: has_participant CCO:B0001483 ! P53_HUMAN relationship: has_participant CCO:B0001485 ! INHA_HUMAN relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001496 ! FUMH_HUMAN relationship: has_participant CCO:B0001498 ! INHBA_HUMAN relationship: has_participant CCO:B0001510 ! IRF1_HUMAN relationship: has_participant CCO:B0001515 ! BMP2_HUMAN relationship: has_participant CCO:B0001516 ! BMP4_HUMAN relationship: has_participant CCO:B0001523 ! PGDH_HUMAN relationship: has_participant CCO:B0001524 ! NDKA_HUMAN relationship: has_participant CCO:B0001531 ! BMP7_HUMAN relationship: has_participant CCO:B0001536 ! WT1_HUMAN relationship: has_participant CCO:B0001542 ! NF1_HUMAN relationship: has_participant CCO:B0001546 ! NDKB_HUMAN relationship: has_participant CCO:B0001549 ! CRCM_HUMAN relationship: has_participant CCO:B0001556 ! APC_HUMAN relationship: has_participant CCO:B0001567 ! RBL1_HUMAN relationship: has_participant CCO:B0001568 ! EPHB2_HUMAN relationship: has_participant CCO:B0001592 ! MERL_HUMAN relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: has_participant CCO:B0001600 ! VHL_HUMAN relationship: has_participant CCO:B0001601 ! MLH1_HUMAN relationship: has_participant CCO:B0001607 ! NBL1_HUMAN relationship: has_participant CCO:B0001615 ! CD2A1_HUMAN relationship: has_participant CCO:B0001616 ! CDN2B_HUMAN relationship: has_participant CCO:B0001619 ! DCC_HUMAN relationship: has_participant CCO:B0001620 ! MSH2_HUMAN relationship: has_participant CCO:B0001630 ! CTCF_HUMAN relationship: has_participant CCO:B0001636 ! FHIT_HUMAN relationship: has_participant CCO:B0001637 ! TSC2_HUMAN relationship: has_participant CCO:B0001640 ! CDN1C_HUMAN relationship: has_participant CCO:B0001646 ! RASF2_HUMAN relationship: has_participant CCO:B0001660 ! RBM5_HUMAN relationship: has_participant CCO:B0001666 ! HRSL3_HUMAN relationship: has_participant CCO:B0001668 ! PMS1_HUMAN relationship: has_participant CCO:B0001669 ! PMS2_HUMAN relationship: has_participant CCO:B0001675 ! CDN2D_HUMAN relationship: has_participant CCO:B0001685 ! PTEN_HUMAN relationship: has_participant CCO:B0001692 ! RHOB_HUMAN relationship: has_participant CCO:B0001694 ! RAP1A_HUMAN relationship: has_participant CCO:B0001723 ! BAX_HUMAN relationship: has_participant CCO:B0001725 ! RBL2_HUMAN relationship: has_participant CCO:B0001732 ! SNF5_HUMAN relationship: has_participant CCO:B0001741 ! ZBT17_HUMAN relationship: has_participant CCO:B0001750 ! ATM_HUMAN relationship: has_participant CCO:B0001764 ! ASPP2_HUMAN relationship: has_participant CCO:B0001765 ! PTC1_HUMAN relationship: has_participant CCO:B0001766 ! RUNX3_HUMAN relationship: has_participant CCO:B0001783 ! HIC1_HUMAN relationship: has_participant CCO:B0001789 ! KANK1_HUMAN relationship: has_participant CCO:B0001818 ! EXT1_HUMAN relationship: has_participant CCO:B0001831 ! Q3LRW5_HUMAN relationship: has_participant CCO:B0001832 ! TBRG1_HUMAN relationship: has_participant CCO:B0001836 ! PDCD4_HUMAN relationship: has_participant CCO:B0001838 ! PKHO1_HUMAN relationship: has_participant CCO:B0001894 ! LIN9_HUMAN relationship: has_participant CCO:B0001899 ! DAB2P_HUMAN relationship: has_participant CCO:B0001904 ! KCD11_HUMAN relationship: has_participant CCO:B0001911 ! CDC73_HUMAN relationship: has_participant CCO:B0001954 ! XRN1_HUMAN relationship: has_participant CCO:B0001966 ! CD2A2_HUMAN relationship: has_participant CCO:B0001971 ! BANP_HUMAN relationship: has_participant CCO:B0001978 ! PPC1B_HUMAN relationship: has_participant CCO:B0001981 ! FLCN_HUMAN relationship: has_participant CCO:B0001983 ! CADM4_HUMAN relationship: has_participant CCO:B0001995 ! RBCC1_HUMAN relationship: has_participant CCO:B0002000 ! TUSC4_HUMAN relationship: has_participant CCO:B0002008 ! RASF5_HUMAN relationship: has_participant CCO:B0002014 ! TSC1_HUMAN relationship: has_participant CCO:B0002026 ! NAT6_HUMAN relationship: has_participant CCO:B0002028 ! EXT2_HUMAN relationship: has_participant CCO:B0002033 ! PINX1_HUMAN relationship: has_participant CCO:B0002039 ! SIPA1_HUMAN relationship: has_participant CCO:B0002046 ! ASPP1_HUMAN relationship: has_participant CCO:B0002094 ! LZTS2_HUMAN relationship: has_participant CCO:B0002098 ! HTAI2_HUMAN relationship: has_participant CCO:B0002110 ! CADM1_HUMAN relationship: has_participant CCO:B0002117 ! DPH1_HUMAN relationship: has_participant CCO:B0002128 ! TSYL2_HUMAN relationship: has_participant CCO:B0002129 ! RASF4_HUMAN relationship: has_participant CCO:B0002131 ! PININ_HUMAN relationship: has_participant CCO:B0002147 ! BRMS1_HUMAN relationship: has_participant CCO:B0002153 ! CYLD_HUMAN relationship: has_participant CCO:B0002159 ! LATS2_HUMAN relationship: has_participant CCO:B0002160 ! GRLF1_HUMAN relationship: has_participant CCO:B0002162 ! RASF1_HUMAN relationship: has_participant CCO:B0002181 ! WWOX_HUMAN relationship: has_participant CCO:B0002188 ! RHG20_HUMAN relationship: has_participant CCO:B0002189 ! DEC1_HUMAN relationship: has_participant CCO:B0002197 ! DMBT1_HUMAN relationship: has_participant CCO:B0002201 ! SEPT9_HUMAN relationship: has_participant CCO:B0002205 ! MUTYH_HUMAN relationship: has_participant CCO:B0002217 ! ING1_HUMAN relationship: has_participant CCO:B0002224 ! MTUS1_HUMAN relationship: has_participant CCO:B0002228 ! ASC_HUMAN relationship: has_participant CCO:B0002232 ! SUFU_HUMAN relationship: has_participant CCO:B0002234 ! ING4_HUMAN relationship: has_participant CCO:B0002247 ! DLEC1_HUMAN relationship: has_participant CCO:B0002248 ! LZTS1_HUMAN relationship: has_participant CCO:B0002253 ! STA13_HUMAN relationship: has_participant CCO:B0022308 ! Q1MSW9_HUMAN relationship: has_participant CCO:B0026249 ! ZMY11_HUMAN relationship: has_participant CCO:B0035935 ! MEN1_HUMAN relationship: has_participant CCO:B0039945 ! CRBL2_HUMAN relationship: has_participant CCO:B0041254 ! PTOR1_HUMAN relationship: has_participant CCO:B0041258 ! XAF1_HUMAN relationship: has_participant CCO:B0041264 ! PRDBP_HUMAN relationship: has_participant CCO:B0041267 ! DMTF1_HUMAN relationship: negatively_regulates CCO:P0000066 ! cell cycle [Term] id: CCO:P0000247 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] xref: GO:0045787 is_a: CCO:P0000346 ! regulation of cell cycle relationship: has_participant CCO:B0001365 ! TBX3_HUMAN relationship: has_participant CCO:B0001650 ! HCFC1_HUMAN relationship: has_participant CCO:B0001687 ! TGFB2_HUMAN relationship: has_participant CCO:B0002091 ! CITE2_HUMAN relationship: positively_regulates CCO:P0000066 ! cell cycle [Term] id: CCO:P0000248 name: negative regulation of meiosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "down regulation of meiosis" EXACT [] synonym: "down-regulation of meiosis" EXACT [] synonym: "downregulation of meiosis" EXACT [] synonym: "inhibition of meiosis" NARROW [] xref: GO:0045835 is_a: CCO:P0000226 ! regulation of meiosis relationship: negatively_regulates CCO:P0000117 ! meiosis [Term] id: CCO:P0000249 name: positive regulation of meiosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "activation of meiosis" NARROW [] synonym: "stimulation of meiosis" NARROW [] synonym: "up regulation of meiosis" EXACT [] synonym: "up-regulation of meiosis" EXACT [] synonym: "upregulation of meiosis" EXACT [] xref: GO:0045836 is_a: CCO:P0000226 ! regulation of meiosis relationship: has_participant CCO:B0001936 ! NPM2_HUMAN relationship: positively_regulates CCO:P0000117 ! meiosis [Term] id: CCO:P0000250 name: negative regulation of mitosis namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of mitosis" EXACT [] synonym: "down-regulation of mitosis" EXACT [] synonym: "downregulation of mitosis" EXACT [] synonym: "inhibition of mitosis" NARROW [] xref: GO:0045839 is_a: CCO:P0000099 ! regulation of mitosis is_a: CCO:P0000246 ! negative regulation of cell cycle relationship: has_participant CCO:B0002171 ! AKIP_HUMAN relationship: negatively_regulates CCO:P0000081 ! mitosis [Term] id: CCO:P0000251 name: positive regulation of mitosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "activation of mitosis" NARROW [] synonym: "mitogenic activity" NARROW [] synonym: "stimulation of mitosis" NARROW [] synonym: "up regulation of mitosis" EXACT [] synonym: "up-regulation of mitosis" EXACT [] synonym: "upregulation of mitosis" EXACT [] xref: GO:0045840 is_a: CCO:P0000099 ! regulation of mitosis is_a: CCO:P0000247 ! positive regulation of cell cycle relationship: has_participant CCO:B0001362 ! EREG_HUMAN relationship: has_participant CCO:B0001470 ! EGF_HUMAN relationship: has_participant CCO:B0001508 ! CD28_HUMAN relationship: has_participant CCO:B0001569 ! SHC1_HUMAN relationship: has_participant CCO:B0001927 ! Q70WG0_HUMAN relationship: has_participant CCO:B0002108 ! NUSAP_HUMAN relationship: has_participant CCO:B0005870 ! TGFA_HUMAN relationship: positively_regulates CCO:P0000081 ! mitosis [Term] id: CCO:P0000252 name: negative regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW [] xref: GO:0045841 is_a: CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition is_a: CCO:P0000250 ! negative regulation of mitosis relationship: negatively_regulates CCO:P0000102 ! mitotic metaphase/anaphase transition [Term] id: CCO:P0000253 name: positive regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] synonym: "activation of mitotic metaphase/anaphase transition" NARROW [] synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW [] synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT [] xref: GO:0045842 is_a: CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition is_a: CCO:P0000251 ! positive regulation of mitosis relationship: has_participant CCO:B0001787 ! ESPL1_HUMAN relationship: has_participant CCO:B0001807 ! DLG7_HUMAN relationship: positively_regulates CCO:P0000102 ! mitotic metaphase/anaphase transition [Term] id: CCO:P0000254 name: negative regulation of sister chromatid cohesion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] synonym: "down regulation of sister chromatid cohesion" EXACT [] synonym: "down-regulation of sister chromatid cohesion" EXACT [] synonym: "downregulation of sister chromatid cohesion" EXACT [] synonym: "inhibition of sister chromatid cohesion" NARROW [] xref: GO:0045875 is_a: CCO:P0000077 ! regulation of sister chromatid cohesion relationship: has_participant CCO:B0001787 ! ESPL1_HUMAN relationship: negatively_regulates CCO:P0000076 ! sister chromatid cohesion [Term] id: CCO:P0000255 name: positive regulation of sister chromatid cohesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] synonym: "activation of sister chromatid cohesion" NARROW [] synonym: "stimulation of sister chromatid cohesion" NARROW [] synonym: "up regulation of sister chromatid cohesion" EXACT [] synonym: "up-regulation of sister chromatid cohesion" EXACT [] synonym: "upregulation of sister chromatid cohesion" EXACT [] xref: GO:0045876 is_a: CCO:P0000077 ! regulation of sister chromatid cohesion relationship: positively_regulates CCO:P0000076 ! sister chromatid cohesion [Term] id: CCO:P0000256 name: regulation of transcription, mitotic namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] synonym: "mitotic regulation of transcription" EXACT [] xref: GO:0045896 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000081 ! mitosis [Term] id: CCO:P0000257 name: positive regulation of transcription, mitotic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] synonym: "activation of transcription, mitotic" NARROW [] synonym: "mitotic activation of transcription" EXACT [] synonym: "stimulation of transcription, mitotic" NARROW [] synonym: "up regulation of transcription, mitotic" EXACT [] synonym: "up-regulation of transcription, mitotic" EXACT [] synonym: "upregulation of transcription, mitotic" EXACT [] xref: GO:0045897 is_a: CCO:P0000256 ! regulation of transcription, mitotic [Term] id: CCO:P0000258 name: negative regulation of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] synonym: "downregulation of progression through mitotic cell cycle" EXACT [] synonym: "inhibition of progression through mitotic cell cycle" NARROW [] synonym: "negative regulation of mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: GO:0045930 is_a: CCO:P0000138 ! regulation of mitotic cell cycle is_a: CCO:P0000246 ! negative regulation of cell cycle relationship: has_participant CCO:B0001735 ! FOXC1_HUMAN relationship: has_participant CCO:B0001736 ! DLG1_HUMAN relationship: has_participant CCO:B0001778 ! BTG3_HUMAN relationship: negatively_regulates CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000259 name: positive regulation of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through mitotic cell cycle" NARROW [] synonym: "positive regulation of mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through mitotic cell cycle" NARROW [] synonym: "up regulation of progression through mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] synonym: "upregulation of progression through mitotic cell cycle" EXACT [] xref: GO:0045931 is_a: CCO:P0000138 ! regulation of mitotic cell cycle is_a: CCO:P0000247 ! positive regulation of cell cycle relationship: has_participant CCO:B0001377 ! BIRC5_HUMAN relationship: has_participant CCO:B0002176 ! SPHK1_HUMAN relationship: has_participant CCO:B0024005 ! UBP22_HUMAN relationship: has_participant CCO:B0032819 ! ASNS_HUMAN relationship: positively_regulates CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000260 name: negative regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT [] synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT [] synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW [] synonym: "negative regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: GO:0045976 is_a: CCO:P0000145 ! regulation of mitotic cell cycle, embryonic is_a: CCO:P0000258 ! negative regulation of mitotic cell cycle relationship: negatively_regulates CCO:P0000241 ! mitotic cell cycle, embryonic [Term] id: CCO:P0000261 name: positive regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of mitotic cell cycle, embryonic" NARROW [] synonym: "positive regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of mitotic cell cycle, embryonic" NARROW [] synonym: "up regulation of mitotic cell cycle, embryonic" EXACT [] synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT [] synonym: "upregulation of mitotic cell cycle, embryonic" EXACT [] xref: GO:0045977 is_a: CCO:P0000145 ! regulation of mitotic cell cycle, embryonic is_a: CCO:P0000259 ! positive regulation of mitotic cell cycle relationship: positively_regulates CCO:P0000241 ! mitotic cell cycle, embryonic [Term] id: CCO:P0000262 name: negative regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW [] synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: GO:0046001 is_a: CCO:P0000139 ! regulation of preblastoderm mitotic cell cycle is_a: CCO:P0000260 ! negative regulation of mitotic cell cycle, embryonic relationship: negatively_regulates CCO:P0000223 ! preblastoderm mitotic cell cycle [Term] id: CCO:P0000263 name: positive regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW [] synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW [] synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT [] xref: GO:0046002 is_a: CCO:P0000139 ! regulation of preblastoderm mitotic cell cycle is_a: CCO:P0000261 ! positive regulation of mitotic cell cycle, embryonic relationship: positively_regulates CCO:P0000223 ! preblastoderm mitotic cell cycle [Term] id: CCO:P0000264 name: negative regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW [] synonym: "negative regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT [] xref: GO:0046003 is_a: CCO:P0000140 ! regulation of syncytial blastoderm mitotic cell cycle is_a: CCO:P0000260 ! negative regulation of mitotic cell cycle, embryonic relationship: negatively_regulates CCO:P0000224 ! syncytial blastoderm mitotic cell cycle [Term] id: CCO:P0000265 name: positive regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] synonym: "positive regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] xref: GO:0046004 is_a: CCO:P0000140 ! regulation of syncytial blastoderm mitotic cell cycle is_a: CCO:P0000261 ! positive regulation of mitotic cell cycle, embryonic relationship: positively_regulates CCO:P0000224 ! syncytial blastoderm mitotic cell cycle [Term] id: CCO:P0000266 name: regulation of transcription from RNA polymerase I promoter, mitotic namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] synonym: "mitotic regulation of transcription from Pol I promoter" EXACT [] synonym: "regulation of transcription from Pol I promoter, mitotic" EXACT [] xref: GO:0046017 is_a: CCO:P0000256 ! regulation of transcription, mitotic [Term] id: CCO:P0000267 name: positive regulation of transcription from RNA polymerase I promoter, mitotic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase I promoter, mitotic" NARROW [] synonym: "mitotic activation of transcription from Pol I promoter" EXACT [] synonym: "positive regulation of transcription from Pol I promoter, mitotic" EXACT [] synonym: "stimulation of transcription from RNA polymerase I promoter, mitotic" NARROW [] synonym: "up regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] synonym: "up-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] synonym: "upregulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] xref: GO:0046018 is_a: CCO:P0000257 ! positive regulation of transcription, mitotic is_a: CCO:P0000266 ! regulation of transcription from RNA polymerase I promoter, mitotic [Term] id: CCO:P0000268 name: regulation of transcription from RNA polymerase II promoter, mitotic namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] synonym: "mitotic regulation of transcription from Pol II promoter" EXACT [] synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT [] xref: GO:0046021 is_a: CCO:P0000256 ! regulation of transcription, mitotic [Term] id: CCO:P0000269 name: positive regulation of transcription from RNA polymerase II promoter, mitotic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase II promoter, mitotic" NARROW [] synonym: "mitotic activation of transcription from Pol II promoter" EXACT [] synonym: "positive regulation of transcription from Pol II promoter, mitotic" EXACT [] synonym: "stimulation of transcription from RNA polymerase II promoter, mitotic" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] xref: GO:0046022 is_a: CCO:P0000257 ! positive regulation of transcription, mitotic is_a: CCO:P0000268 ! regulation of transcription from RNA polymerase II promoter, mitotic [Term] id: CCO:P0000270 name: regulation of transcription from RNA polymerase III promoter, mitotic namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] synonym: "mitotic regulation of transcription from Pol III promoter" EXACT [] synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT [] xref: GO:0046023 is_a: CCO:P0000256 ! regulation of transcription, mitotic [Term] id: CCO:P0000271 name: positive regulation of transcription from RNA polymerase III promoter, mitotic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase III promoter, mitotic" NARROW [] synonym: "mitotic activation of transcription from Pol III promoter" EXACT [] synonym: "positive regulation of transcription from Pol III promoter, mitotic" EXACT [] synonym: "stimulation of transcription from RNA polymerase III promoter, mitotic" NARROW [] synonym: "up regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] synonym: "up-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] synonym: "upregulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] xref: GO:0046024 is_a: CCO:P0000257 ! positive regulation of transcription, mitotic is_a: CCO:P0000270 ! regulation of transcription from RNA polymerase III promoter, mitotic [Term] id: CCO:P0000272 name: regulation of centriole replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai] xref: GO:0046599 is_a: CCO:P0000278 ! regulation of centrosome cycle relationship: regulates CCO:P0000109 ! centriole replication [Term] id: CCO:P0000273 name: negative regulation of centriole replication namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole replication." [GOC:ai] synonym: "down regulation of centriole replication" EXACT [] synonym: "down-regulation of centriole replication" EXACT [] synonym: "downregulation of centriole replication" EXACT [] synonym: "inhibition of centriole replication" NARROW [] xref: GO:0046600 is_a: CCO:P0000272 ! regulation of centriole replication is_a: CCO:P0000279 ! negative regulation of centrosome cycle relationship: has_participant CCO:B0001598 ! BRCA1_HUMAN relationship: negatively_regulates CCO:P0000109 ! centriole replication [Term] id: CCO:P0000274 name: positive regulation of centriole replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai] synonym: "activation of centriole replication" NARROW [] synonym: "stimulation of centriole replication" NARROW [] synonym: "up regulation of centriole replication" EXACT [] synonym: "up-regulation of centriole replication" EXACT [] synonym: "upregulation of centriole replication" EXACT [] xref: GO:0046601 is_a: CCO:P0000272 ! regulation of centriole replication is_a: CCO:P0000280 ! positive regulation of centrosome cycle relationship: positively_regulates CCO:P0000109 ! centriole replication [Term] id: CCO:P0000275 name: regulation of mitotic centrosome separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai] xref: GO:0046602 is_a: CCO:P0000278 ! regulation of centrosome cycle relationship: regulates CCO:P0000110 ! mitotic centrosome separation [Term] id: CCO:P0000276 name: negative regulation of mitotic centrosome separation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of centrosome separation." [GOC:ai] synonym: "down regulation of mitotic centrosome separation" EXACT [] synonym: "down-regulation of mitotic centrosome separation" EXACT [] synonym: "downregulation of mitotic centrosome separation" EXACT [] synonym: "inhibition of mitotic centrosome separation" NARROW [] xref: GO:0046603 is_a: CCO:P0000275 ! regulation of mitotic centrosome separation is_a: CCO:P0000279 ! negative regulation of centrosome cycle relationship: negatively_regulates CCO:P0000110 ! mitotic centrosome separation [Term] id: CCO:P0000277 name: positive regulation of mitotic centrosome separation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai] synonym: "activation of mitotic centrosome separation" NARROW [] synonym: "stimulation of mitotic centrosome separation" NARROW [] synonym: "up regulation of mitotic centrosome separation" EXACT [] synonym: "up-regulation of mitotic centrosome separation" EXACT [] synonym: "upregulation of mitotic centrosome separation" EXACT [] xref: GO:0046604 is_a: CCO:P0000275 ! regulation of mitotic centrosome separation is_a: CCO:P0000280 ! positive regulation of centrosome cycle relationship: positively_regulates CCO:P0000110 ! mitotic centrosome separation [Term] id: CCO:P0000278 name: regulation of centrosome cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai] xref: GO:0046605 is_a: CCO:P0000382 ! regulation of cell cycle process relationship: regulates CCO:P0000108 ! centrosome cycle [Term] id: CCO:P0000279 name: negative regulation of centrosome cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai] synonym: "down regulation of centrosome cycle" EXACT [] synonym: "down-regulation of centrosome cycle" EXACT [] synonym: "downregulation of centrosome cycle" EXACT [] synonym: "inhibition of centrosome cycle" NARROW [] xref: GO:0046606 is_a: CCO:P0000278 ! regulation of centrosome cycle relationship: negatively_regulates CCO:P0000108 ! centrosome cycle [Term] id: CCO:P0000280 name: positive regulation of centrosome cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai] synonym: "activation of centrosome cycle" NARROW [] synonym: "stimulation of centrosome cycle" NARROW [] synonym: "up regulation of centrosome cycle" EXACT [] synonym: "up-regulation of centrosome cycle" EXACT [] synonym: "upregulation of centrosome cycle" EXACT [] xref: GO:0046607 is_a: CCO:P0000278 ! regulation of centrosome cycle relationship: positively_regulates CCO:P0000108 ! centrosome cycle [Term] id: CCO:P0000282 name: chiasma formation namespace: biological_process def: "The cell cycle process whereby a connection between chromatids forms, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [http://www.onelook.com] xref: GO:0051026 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000120 ! synapsis [Term] id: CCO:P0000286 name: meiotic nuclear envelope disassembly namespace: biological_process def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf] synonym: "meiotic nuclear envelope breakdown" EXACT [] synonym: "meiotic nuclear envelope catabolism" EXACT [] synonym: "meiotic nuclear envelope degradation" EXACT [] xref: GO:0051078 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000287 name: meiosis I nuclear envelope disassembly namespace: biological_process def: "The controlled breakdown of the nuclear envelope during the first division of meiosis." [GOC:bf] synonym: "meiosis I nuclear envelope breakdown" EXACT [] synonym: "meiosis I nuclear envelope catabolism" EXACT [] synonym: "meiosis I nuclear envelope degradation" EXACT [] xref: GO:0051079 is_a: CCO:P0000286 ! meiotic nuclear envelope disassembly relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000288 name: meiosis II nuclear envelope disassembly namespace: biological_process def: "The controlled breakdown of the nuclear envelope during the second division of meiosis." [GOC:bf] synonym: "meiosis II nuclear envelope breakdown" EXACT [] synonym: "meiosis II nuclear envelope catabolism" EXACT [] synonym: "meiosis II nuclear envelope degradation" EXACT [] xref: GO:0051080 is_a: CCO:P0000286 ! meiotic nuclear envelope disassembly relationship: part_of CCO:P0000126 ! meiosis II [Term] id: CCO:P0000289 name: meiotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai] xref: GO:0051177 is_a: CCO:P0000076 ! sister chromatid cohesion relationship: part_of CCO:P0000118 ! meiosis I relationship: part_of CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000290 name: meiotic chromosome decondensation namespace: biological_process def: "The cell cycle process whereby chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai] xref: GO:0051178 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000291 name: mitotic spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai] synonym: "mitotic spindle breakdown" EXACT [] synonym: "mitotic spindle catabolism" EXACT [] synonym: "mitotic spindle degradation" EXACT [] synonym: "spindle breakdown during mitosis" EXACT [] synonym: "spindle degradation during mitosis" EXACT [] synonym: "spindle disassembly during mitosis" EXACT [] xref: GO:0051228 is_a: CCO:P0000068 ! mitotic spindle organization and biogenesis [Term] id: CCO:P0000292 name: meiotic spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai] synonym: "meiotic spindle breakdown" EXACT [] synonym: "meiotic spindle catabolism" EXACT [] synonym: "meiotic spindle degradation" EXACT [] synonym: "spindle breakdown during meiosis" EXACT [] synonym: "spindle degradation during meiosis" EXACT [] synonym: "spindle disassembly during meiosis" EXACT [] xref: GO:0051229 is_a: CCO:P0000030 ! meiotic spindle organization and biogenesis [Term] id: CCO:P0000293 name: spindle elongation namespace: biological_process def: "The cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:ai] xref: GO:0051231 is_a: CCO:P0000159 ! cell cycle process [Term] id: CCO:P0000294 name: meiotic spindle elongation namespace: biological_process def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai] synonym: "spindle elongation during meiosis" EXACT [] xref: GO:0051232 is_a: CCO:P0000293 ! spindle elongation relationship: part_of CCO:P0000030 ! meiotic spindle organization and biogenesis [Term] id: CCO:P0000295 name: spindle midzone assembly namespace: biological_process def: "The cell cycle process whereby aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] synonym: "spindle midzone biogenesis" EXACT [] synonym: "spindle midzone biosynthesis" EXACT [] synonym: "spindle midzone formation" EXACT [] xref: GO:0051255 is_a: CCO:P0000159 ! cell cycle process [Term] id: CCO:P0000296 name: spindle midzone assembly involved in mitosis namespace: biological_process def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of mitosis." [GOC:ai, GOC:rg, GOC:tb] synonym: "mitotic spindle midzone assembly" RELATED [] synonym: "mitotic spindle midzone biogenesis" EXACT [] synonym: "mitotic spindle midzone biosynthesis" EXACT [] synonym: "mitotic spindle midzone formation" EXACT [] synonym: "spindle midzone biogenesis involved in mitosis" EXACT [] synonym: "spindle midzone formation involved in mitosis" EXACT [] xref: GO:0051256 is_a: CCO:P0000295 ! spindle midzone assembly [Term] id: CCO:P0000297 name: spindle midzone assembly involved in meiosis namespace: biological_process def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of meiosis." [GOC:ai, GOC:rg, GOC:tb] synonym: "meiotic spindle midzone assembly" RELATED [] synonym: "meiotic spindle midzone biogenesis" EXACT [] synonym: "meiotic spindle midzone biosynthesis" EXACT [] synonym: "meiotic spindle midzone formation" EXACT [] synonym: "spindle midzone biogenesis involved in meiosis" EXACT [] synonym: "spindle midzone biosynthesis involved in meiosis" EXACT [] synonym: "spindle midzone formation involved in meiosis" EXACT [] xref: GO:0051257 is_a: CCO:P0000295 ! spindle midzone assembly [Term] id: CCO:P0000298 name: establishment of meiotic spindle localization namespace: biological_process def: "The cell cycle process whereby the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai] synonym: "meiotic spindle positioning" EXACT [] synonym: "spindle positioning during meiosis" EXACT [] xref: GO:0051295 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000299 name: establishment of meiotic spindle orientation namespace: biological_process def: "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai] synonym: "establishment of spindle orientation during meiosis" EXACT [] synonym: "meiotic spindle orientation" EXACT [] synonym: "orienting of meiotic spindle" EXACT [] xref: GO:0051296 is_a: CCO:P0000298 ! establishment of meiotic spindle localization [Term] id: CCO:P0000300 name: centrosome duplication namespace: biological_process def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] synonym: "centrosome replication" EXACT [] xref: GO:0051298 is_a: CCO:U0000002 ! biological process relationship: has_participant CCO:B0001389 ! CE110_HUMAN relationship: has_participant CCO:B0001649 ! BRCA2_HUMAN relationship: has_participant CCO:B0001918 ! SAS6_HUMAN relationship: has_participant CCO:B0002088 ! Q99773_HUMAN relationship: has_participant CCO:B0002173 ! NDE1_HUMAN relationship: part_of CCO:P0000108 ! centrosome cycle [Term] id: CCO:P0000301 name: centrosome separation namespace: biological_process def: "The process by which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] xref: GO:0051299 is_a: CCO:U0000002 ! biological process relationship: has_participant CCO:B0001961 ! CNTRB_HUMAN relationship: part_of CCO:P0000108 ! centrosome cycle [Term] id: CCO:P0000302 name: spindle pole body organization and biogenesis namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:mah] synonym: "SPB organization and biogenesis" EXACT [] synonym: "spindle pole body organisation and biogenesis" EXACT [] xref: GO:0051300 is_a: CCO:P0000159 ! cell cycle process relationship: has_participant CCO:B0001659 ! KIF11_HUMAN relationship: has_participant CCO:B0001772 ! CKAP5_HUMAN [Term] id: CCO:P0000303 name: chromosome separation namespace: biological_process def: "The cell cycle process whereby paired chromosomes are detached from each other. In budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions." [GOC:ai] xref: GO:0051304 is_a: CCO:P0000159 ! cell cycle process [Term] id: CCO:P0000304 name: mitotic sister chromatid separation namespace: biological_process def: "The process by which sister chromatids are physically detached from each other during mitosis." [GOC:ai] synonym: "chromosome separation during mitosis" RELATED [] synonym: "mitotic chromosome separation" RELATED [] synonym: "sister chromatid separation during mitosis" EXACT [] xref: GO:0051306 is_a: CCO:P0000303 ! chromosome separation relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000305 name: meiotic chromosome separation namespace: biological_process def: "The process by which chromosomes are physically detached from each other during meiosis." [GOC:ai] synonym: "chromosome separation during meiosis" EXACT [] xref: GO:0051307 is_a: CCO:P0000303 ! chromosome separation relationship: part_of CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000306 name: male meiosis chromosome separation namespace: biological_process def: "The process by which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai] synonym: "chromosome separation during male meiosis" EXACT [] xref: GO:0051308 is_a: CCO:P0000075 ! male meiosis chromosome segregation is_a: CCO:P0000305 ! meiotic chromosome separation [Term] id: CCO:P0000307 name: female meiosis chromosome separation namespace: biological_process def: "The process by which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai] synonym: "chromosome separation during female meiosis" EXACT [] xref: GO:0051309 is_a: CCO:P0000153 ! female meiosis chromosome segregation is_a: CCO:P0000305 ! meiotic chromosome separation [Term] id: CCO:P0000308 name: meiotic metaphase plate congression namespace: biological_process def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai] synonym: "metaphase plate congression during meiosis" EXACT [] xref: GO:0051311 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000309 name: attachment of spindle microtubules to mitotic chromosome namespace: biological_process def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during mitosis." [GOC:ai] xref: GO:0051314 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000310 name: attachment of spindle microtubules to kinetochore during mitosis namespace: biological_process def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt] xref: GO:0051315 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation [Term] id: CCO:P0000311 name: attachment of spindle microtubules to kinetochore during meiotic chromosome segregation namespace: biological_process def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiotic chromosome segregation." [GOC:ai] synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED [] xref: GO:0051316 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000312 name: attachment of spindle microtubules to meiotic chromosome namespace: biological_process def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during meiosis." [GOC:ai] xref: GO:0051317 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000237 ! meiotic chromosome segregation [Term] id: CCO:P0000313 name: G1 phase namespace: biological_process def: "Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:ai] xref: GO:0051318 is_a: CCO:P0000160 ! cell cycle phase relationship: has_participant CCO:B0001491 ! RB_HUMAN relationship: has_participant CCO:B0001842 ! BMCC1_HUMAN relationship: part_of CCO:P0000320 ! interphase [Term] id: CCO:P0000314 name: G2 phase namespace: biological_process def: "Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:ai] xref: GO:0051319 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000320 ! interphase [Term] id: CCO:P0000315 name: S phase namespace: biological_process def: "Progression through S phase, the part of the cell cycle during which DNA synthesis takes place." [GOC:ai] xref: GO:0051320 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000320 ! interphase [Term] id: CCO:P0000316 name: meiotic cell cycle namespace: biological_process def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai] xref: GO:0051321 is_a: CCO:P0000066 ! cell cycle [Term] id: CCO:P0000317 name: anaphase namespace: biological_process def: "Progression through anaphase, the third stage of chromosome segregation in the cell cycle. Canonically, sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle." [http://www.onelook.com] xref: GO:0051322 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000039 ! M phase [Term] id: CCO:P0000318 name: metaphase namespace: biological_process def: "Progression through metaphase, the second stage of chromosome segregation in the cell cycle. Canonically, chromosomes become aligned on the equatorial plate of the cell." [http://www.onelook.com] xref: GO:0051323 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000039 ! M phase [Term] id: CCO:P0000319 name: prophase namespace: biological_process def: "Progression through prophase, the first stage of chromosome segregation in the cell cycle. Canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:ai] xref: GO:0051324 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000039 ! M phase [Term] id: CCO:P0000320 name: interphase namespace: biological_process def: "Progression through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [http://www.onelook.com] synonym: "karyostasis" EXACT [] synonym: "resting phase" BROAD [] xref: GO:0051325 is_a: CCO:P0000160 ! cell cycle phase relationship: has_participant CCO:B0001501 ! K2C7_HUMAN [Term] id: CCO:P0000321 name: telophase namespace: biological_process def: "Progression through telophase, the last stage of chromosome segregation in the cell cycle. Canonically, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [http://www.onelook.com] xref: GO:0051326 is_a: CCO:P0000160 ! cell cycle phase relationship: part_of CCO:P0000039 ! M phase [Term] id: CCO:P0000322 name: M phase of meiotic cell cycle namespace: biological_process def: "Progression through M phase, the part of the meiotic cell cycle during which meiosis takes place." [GOC:ai] xref: GO:0051327 is_a: CCO:P0000039 ! M phase relationship: part_of CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000323 name: interphase of meiotic cell cycle namespace: biological_process def: "Progression through interphase, the stage of cell cycle between successive rounds of meiosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai] xref: GO:0051328 is_a: CCO:P0000320 ! interphase relationship: part_of CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000324 name: interphase of mitotic cell cycle namespace: biological_process def: "Progression through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai] xref: GO:0051329 is_a: CCO:P0000320 ! interphase relationship: has_participant CCO:B0001427 ! KTNA1_HUMAN relationship: has_participant CCO:B0002038 ! CDCA5_HUMAN relationship: part_of CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000325 name: G1 phase of meiotic cell cycle namespace: biological_process def: "Progression through G1 phase, one of two 'gap' phases in the meiotic cell cycle; G1 is the interval between the completion of meiosis and the beginning of DNA synthesis." [GOC:ai] xref: GO:0051330 is_a: CCO:P0000313 ! G1 phase relationship: part_of CCO:P0000323 ! interphase of meiotic cell cycle [Term] id: CCO:P0000326 name: G2 phase of meiotic cell cycle namespace: biological_process def: "Progression through G2 phase, one of two 'gap' phases in the meiotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of meiosis." [GOC:ai] xref: GO:0051331 is_a: CCO:P0000314 ! G2 phase relationship: part_of CCO:P0000323 ! interphase of meiotic cell cycle [Term] id: CCO:P0000327 name: S phase of meiotic cell cycle namespace: biological_process def: "Progression through S phase, the part of the meiotic cell cycle during which DNA synthesis takes place." [GOC:ai] xref: GO:0051332 is_a: CCO:P0000315 ! S phase relationship: part_of CCO:P0000323 ! interphase of meiotic cell cycle [Term] id: CCO:P0000328 name: meiotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process whereby the reformation of the nuclear envelope during meiosis occurs." [GOC:ai] xref: GO:0051333 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000329 name: meiosis I nuclear envelope reassembly namespace: biological_process def: "The reformation of the nuclear envelope during meiosis I." [GOC:ai] xref: GO:0051334 is_a: CCO:P0000328 ! meiotic nuclear envelope reassembly relationship: part_of CCO:P0000118 ! meiosis I [Term] id: CCO:P0000330 name: meiosis II nuclear envelope reassembly namespace: biological_process def: "The reformation of the nuclear envelope during meiosis II." [GOC:ai] xref: GO:0051335 is_a: CCO:P0000328 ! meiotic nuclear envelope reassembly relationship: part_of CCO:P0000126 ! meiosis II [Term] id: CCO:P0000331 name: interphase microtubule nucleation by interphase microtubule organizing center namespace: biological_process def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai] synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT [] synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT [] synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT [] synonym: "microtubule nucleation during interphase by IMTOC" EXACT [] synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT [] xref: GO:0051415 is_a: CCO:U0000002 ! biological process relationship: part_of CCO:P0000320 ! interphase [Term] id: CCO:P0000332 name: spindle pole body maturation namespace: biological_process def: "Any process by which the newly duplicated spindle pole body (SPB) is processed to attain its full functional capacity. In S. pombe, early maturation includes increase in size of the lamellar bodies, invagination of the nuclear envelope, and accumulation of material in a pocket under the SPB. Late maturation includes fenestration of the nuclear envelope, SPB separation and entry into the nucleus, giving rise to the spindle." [GOC:ai, PMID:15132994, PMID:15385623] synonym: "SPB maturation" EXACT [] xref: GO:0051426 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000302 ! spindle pole body organization and biogenesis [Term] id: CCO:P0000333 name: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai, GOC:tb] synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW [] synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW [] synonym: "APC inhibition during mitotic cell cycle" NARROW [] synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "mitotic anaphase promoting complex inhibition" NARROW [] synonym: "mitotic anaphase promoting complex inhibitor" NARROW [] synonym: "mitotic anaphase-promoting complex inhibition" NARROW [] synonym: "mitotic anaphase-promoting complex inhibitor" NARROW [] synonym: "mitotic APC inhibition" NARROW [] synonym: "mitotic APC inhibitor" NARROW [] synonym: "mitotic SCF complex inhibitor" NARROW [] synonym: "mitotic ubiquitin ligase inhibitor" NARROW [] synonym: "negative regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [GOC:tb] xref: GO:0051436 xref: Reactome:141405 xref: Reactome:174079 xref: Reactome:174084 xref: Reactome:174097 xref: Reactome:174139 xref: Reactome:174235 xref: Reactome:174251 xref: Reactome:205333 xref: Reactome:205338 xref: Reactome:207432 xref: Reactome:210208 xref: Reactome:210209 xref: Reactome:211754 xref: Reactome:211831 xref: Reactome:214680 xref: Reactome:214685 xref: Reactome:217035 xref: Reactome:220042 xref: Reactome:220043 xref: Reactome:221521 xref: Reactome:221596 xref: Reactome:224156 xref: Reactome:224161 xref: Reactome:225859 xref: Reactome:228630 xref: Reactome:228631 xref: Reactome:230140 xref: Reactome:230196 xref: Reactome:232620 xref: Reactome:232625 xref: Reactome:234526 xref: Reactome:236793 xref: Reactome:236794 xref: Reactome:238166 xref: Reactome:238230 xref: Reactome:242235 xref: Reactome:243841 xref: Reactome:243842 xref: Reactome:244755 xref: Reactome:244807 xref: Reactome:248864 xref: Reactome:251887 xref: Reactome:252478 xref: Reactome:255069 xref: Reactome:255640 xref: Reactome:258367 xref: Reactome:259034 xref: Reactome:261840 xref: Reactome:262399 xref: Reactome:264678 xref: Reactome:265238 xref: Reactome:267832 xref: Reactome:267834 xref: Reactome:268363 xref: Reactome:272160 xref: Reactome:273334 xref: Reactome:273335 xref: Reactome:274029 xref: Reactome:274074 xref: Reactome:278147 xref: Reactome:279794 xref: Reactome:279795 xref: Reactome:280507 xref: Reactome:280548 xref: Reactome:282372 xref: Reactome:285037 xref: Reactome:285935 xref: Reactome:285936 xref: Reactome:286529 xref: Reactome:286565 is_a: CCO:P0000335 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: has_participant CCO:B0001354 ! UBE2C_HUMAN relationship: has_participant CCO:B0001396 ! BUB3_HUMAN relationship: has_participant CCO:B0001411 ! BUB1B_HUMAN relationship: has_participant CCO:B0001572 ! CDC27_HUMAN relationship: has_participant CCO:B0001625 ! PSMD8_HUMAN relationship: has_participant CCO:B0001733 ! CDC20_HUMAN relationship: has_participant CCO:B0001739 ! CDC16_HUMAN relationship: has_participant CCO:B0001745 ! PSMD2_HUMAN relationship: has_participant CCO:B0001748 ! MD2L1_HUMAN relationship: has_participant CCO:B0001986 ! CDC26_HUMAN relationship: has_participant CCO:B0002066 ! PSMD1_HUMAN relationship: has_participant CCO:B0002125 ! APC1_HUMAN relationship: has_participant CCO:B0002177 ! APC11_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0002213 ! APC7_HUMAN relationship: has_participant CCO:B0002214 ! APC5_HUMAN relationship: has_participant CCO:B0002215 ! APC4_HUMAN relationship: has_participant CCO:B0002216 ! ANC2_HUMAN relationship: has_participant CCO:B0002221 ! FBX5_HUMAN relationship: has_participant CCO:B0002229 ! FZR_HUMAN relationship: has_participant CCO:B0002230 ! APC10_HUMAN relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0005314 ! PRS4_HUMAN relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0006215 ! PSME1_HUMAN relationship: has_participant CCO:B0006219 ! PSB10_HUMAN relationship: has_participant CCO:B0019462 ! UB2D1_HUMAN relationship: has_participant CCO:B0021560 ! PSMD3_HUMAN relationship: has_participant CCO:B0022204 ! PSA5_HUMAN relationship: has_participant CCO:B0023606 ! PSDE_HUMAN relationship: has_participant CCO:B0030768 ! PSA7_HUMAN relationship: has_participant CCO:B0030800 ! PSB2_HUMAN relationship: has_participant CCO:B0030804 ! PSB8_HUMAN relationship: has_participant CCO:B0030806 ! PSB5_HUMAN relationship: has_participant CCO:B0030905 ! PRS10_HUMAN relationship: has_participant CCO:B0030929 ! PSB3_HUMAN relationship: has_participant CCO:B0030961 ! PSB1_HUMAN relationship: has_participant CCO:B0031003 ! PSD7_HUMAN relationship: has_participant CCO:B0031007 ! PSB9_HUMAN relationship: has_participant CCO:B0031015 ! PSB6_HUMAN relationship: has_participant CCO:B0032651 ! PSMD6_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN relationship: has_participant CCO:B0038144 ! PSD12_HUMAN relationship: has_participant CCO:B0041239 ! PSMD9_HUMAN relationship: has_participant CCO:B0041240 ! PSD10_HUMAN relationship: has_participant CCO:B0041242 ! PRS6A_HUMAN relationship: has_participant CCO:B0041243 ! PSA2_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN relationship: has_participant CCO:B0041245 ! PSB4_HUMAN relationship: has_participant CCO:B0041246 ! PRS7_HUMAN relationship: has_participant CCO:B0041247 ! PRS6B_HUMAN relationship: has_participant CCO:B0041248 ! UB2E1_HUMAN relationship: has_participant CCO:B0041250 ! PSMD4_HUMAN relationship: has_participant CCO:B0041251 ! PSA6_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0041253 ! PRS8_HUMAN relationship: has_participant CCO:B0041255 ! PSMD5_HUMAN relationship: has_participant CCO:B0041263 ! PSMF1_HUMAN [Term] id: CCO:P0000334 name: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle namespace: biological_process def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai, GOC:tb] synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "mitotic SCF complex activator" NARROW [] synonym: "mitotic ubiquitin ligase activator" NARROW [] synonym: "positive regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [GOC:tb] synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] xref: GO:0051437 xref: Reactome:174113 xref: Reactome:174238 xref: Reactome:176412 xref: Reactome:204045 xref: Reactome:211808 xref: Reactome:211883 xref: Reactome:213017 xref: Reactome:221572 xref: Reactome:221647 xref: Reactome:222830 xref: Reactome:230174 xref: Reactome:230238 xref: Reactome:231347 xref: Reactome:238210 xref: Reactome:238277 xref: Reactome:239364 xref: Reactome:244788 xref: Reactome:244876 xref: Reactome:249766 xref: Reactome:255691 xref: Reactome:259083 xref: Reactome:262443 xref: Reactome:265278 xref: Reactome:269402 xref: Reactome:274058 xref: Reactome:275312 xref: Reactome:280534 xref: Reactome:283577 xref: Reactome:286552 xref: Reactome:286607 is_a: CCO:P0000335 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle relationship: has_participant CCO:B0001354 ! UBE2C_HUMAN relationship: has_participant CCO:B0001493 ! CDC2_HUMAN relationship: has_participant CCO:B0001519 ! CCNB1_HUMAN relationship: has_participant CCO:B0001572 ! CDC27_HUMAN relationship: has_participant CCO:B0001625 ! PSMD8_HUMAN relationship: has_participant CCO:B0001663 ! PLK1_HUMAN relationship: has_participant CCO:B0001733 ! CDC20_HUMAN relationship: has_participant CCO:B0001739 ! CDC16_HUMAN relationship: has_participant CCO:B0001745 ! PSMD2_HUMAN relationship: has_participant CCO:B0001759 ! CUL1_HUMAN relationship: has_participant CCO:B0001986 ! CDC26_HUMAN relationship: has_participant CCO:B0002066 ! PSMD1_HUMAN relationship: has_participant CCO:B0002125 ! APC1_HUMAN relationship: has_participant CCO:B0002177 ! APC11_HUMAN relationship: has_participant CCO:B0002212 ! CDC23_HUMAN relationship: has_participant CCO:B0002213 ! APC7_HUMAN relationship: has_participant CCO:B0002214 ! APC5_HUMAN relationship: has_participant CCO:B0002215 ! APC4_HUMAN relationship: has_participant CCO:B0002216 ! ANC2_HUMAN relationship: has_participant CCO:B0002221 ! FBX5_HUMAN relationship: has_participant CCO:B0002229 ! FZR_HUMAN relationship: has_participant CCO:B0002230 ! APC10_HUMAN relationship: has_participant CCO:B0005233 ! PSA1_HUMAN relationship: has_participant CCO:B0005314 ! PRS4_HUMAN relationship: has_participant CCO:B0005633 ! FBW1A_HUMAN relationship: has_participant CCO:B0005634 ! SKP1_HUMAN relationship: has_participant CCO:B0005991 ! PSA3_HUMAN relationship: has_participant CCO:B0006215 ! PSME1_HUMAN relationship: has_participant CCO:B0006219 ! PSB10_HUMAN relationship: has_participant CCO:B0019462 ! UB2D1_HUMAN relationship: has_participant CCO:B0021560 ! PSMD3_HUMAN relationship: has_participant CCO:B0022204 ! PSA5_HUMAN relationship: has_participant CCO:B0023606 ! PSDE_HUMAN relationship: has_participant CCO:B0030768 ! PSA7_HUMAN relationship: has_participant CCO:B0030800 ! PSB2_HUMAN relationship: has_participant CCO:B0030804 ! PSB8_HUMAN relationship: has_participant CCO:B0030806 ! PSB5_HUMAN relationship: has_participant CCO:B0030905 ! PRS10_HUMAN relationship: has_participant CCO:B0030929 ! PSB3_HUMAN relationship: has_participant CCO:B0030961 ! PSB1_HUMAN relationship: has_participant CCO:B0031003 ! PSD7_HUMAN relationship: has_participant CCO:B0031007 ! PSB9_HUMAN relationship: has_participant CCO:B0031015 ! PSB6_HUMAN relationship: has_participant CCO:B0032651 ! PSMD6_HUMAN relationship: has_participant CCO:B0034007 ! PSB7_HUMAN relationship: has_participant CCO:B0038144 ! PSD12_HUMAN relationship: has_participant CCO:B0041239 ! PSMD9_HUMAN relationship: has_participant CCO:B0041240 ! PSD10_HUMAN relationship: has_participant CCO:B0041242 ! PRS6A_HUMAN relationship: has_participant CCO:B0041243 ! PSA2_HUMAN relationship: has_participant CCO:B0041244 ! PSA4_HUMAN relationship: has_participant CCO:B0041245 ! PSB4_HUMAN relationship: has_participant CCO:B0041246 ! PRS7_HUMAN relationship: has_participant CCO:B0041247 ! PRS6B_HUMAN relationship: has_participant CCO:B0041248 ! UB2E1_HUMAN relationship: has_participant CCO:B0041250 ! PSMD4_HUMAN relationship: has_participant CCO:B0041251 ! PSA6_HUMAN relationship: has_participant CCO:B0041252 ! PSME3_HUMAN relationship: has_participant CCO:B0041253 ! PRS8_HUMAN relationship: has_participant CCO:B0041255 ! PSMD5_HUMAN relationship: has_participant CCO:B0041263 ! PSMF1_HUMAN [Term] id: CCO:P0000335 name: regulation of ubiquitin-protein ligase activity during mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai] synonym: "mitotic anaphase-promoting complex regulator" NARROW [] synonym: "mitotic APC regulator" NARROW [] synonym: "mitotic SCF complex regulator" NARROW [] synonym: "mitotic ubiquitin ligase regulator" RELATED [] synonym: "mitotic ubiquitin-protein ligase regulator" RELATED [] synonym: "regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [GOC:tb] xref: GO:0051439 xref: Reactome:176407 xref: Reactome:176408 xref: Reactome:211657 xref: Reactome:211661 xref: Reactome:221429 xref: Reactome:221433 xref: Reactome:230061 xref: Reactome:230065 xref: Reactome:238081 xref: Reactome:238084 xref: Reactome:244690 xref: Reactome:244694 xref: Reactome:249666 xref: Reactome:249745 xref: Reactome:252447 xref: Reactome:252500 xref: Reactome:255612 xref: Reactome:255673 xref: Reactome:258992 xref: Reactome:259065 xref: Reactome:262363 xref: Reactome:262427 xref: Reactome:265207 xref: Reactome:265263 xref: Reactome:268331 xref: Reactome:268391 xref: Reactome:273978 xref: Reactome:273981 xref: Reactome:280457 xref: Reactome:280460 xref: Reactome:282833 xref: Reactome:286479 xref: Reactome:286539 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000038 ! mitotic cell cycle [Term] id: CCO:P0000336 name: regulation of ubiquitin-protein ligase activity during meiotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [EC:6.3.2.19, GOC:ai, GOC:tb] synonym: "meiotic anaphase-promoting complex regulator" NARROW [] synonym: "meiotic APC regulator" NARROW [] synonym: "meiotic SCF complex regulator" NARROW [] synonym: "meiotic ubiquitin ligase regulator" RELATED [] synonym: "meiotic ubiquitin-protein ligase regulator" RELATED [] synonym: "regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [GOC:tb] xref: GO:0051440 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000337 name: positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle namespace: biological_process def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] synonym: "meiotic SCF complex activator" NARROW [] synonym: "meiotic ubiquitin ligase activator" NARROW [] synonym: "positive regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [GOC:tb] synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] xref: GO:0051441 is_a: CCO:P0000336 ! regulation of ubiquitin-protein ligase activity during meiotic cell cycle [Term] id: CCO:P0000338 name: negative regulation of ubiquitin-protein ligase activity during meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW [] synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW [] synonym: "APC inhibition during meiotic cell cycle" NARROW [] synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW [] synonym: "meiotic anaphase promoting complex inhibition" NARROW [] synonym: "meiotic anaphase promoting complex inhibitor" NARROW [] synonym: "meiotic anaphase-promoting complex inhibition" NARROW [] synonym: "meiotic anaphase-promoting complex inhibitor" NARROW [] synonym: "meiotic APC inhibition" NARROW [] synonym: "meiotic APC inhibitor" NARROW [] synonym: "meiotic SCF complex inhibitor" NARROW [] synonym: "meiotic ubiquitin ligase inhibitor" NARROW [] synonym: "negative regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [GOC:tb] xref: GO:0051442 is_a: CCO:P0000336 ! regulation of ubiquitin-protein ligase activity during meiotic cell cycle [Term] id: CCO:P0000339 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "control of meiotic cell cycle progression" EXACT [] synonym: "meiotic cell cycle control" EXACT [] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: GO:0051445 is_a: CCO:P0000346 ! regulation of cell cycle relationship: regulates CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000340 name: positive regulation of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of progression through meiotic cell cycle" NARROW [] synonym: "positive regulation of meiotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through meiotic cell cycle" NARROW [] synonym: "up regulation of progression through meiotic cell cycle" EXACT [] synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] synonym: "upregulation of progression through meiotic cell cycle" EXACT [] xref: GO:0051446 is_a: CCO:P0000247 ! positive regulation of cell cycle is_a: CCO:P0000339 ! regulation of meiotic cell cycle relationship: positively_regulates CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000341 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: GO:0051447 is_a: CCO:P0000246 ! negative regulation of cell cycle is_a: CCO:P0000339 ! regulation of meiotic cell cycle relationship: negatively_regulates CCO:P0000316 ! meiotic cell cycle [Term] id: CCO:P0000342 name: attachment of spindle microtubules to kinetochore during meiosis I namespace: biological_process def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt] comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis. synonym: "monopolar attachment" EXACT [] synonym: "sister kinetochore monoorientation" EXACT [] xref: GO:0051455 is_a: CCO:P0000311 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation relationship: part_of CCO:P0000239 ! homologous chromosome segregation [Term] id: CCO:P0000343 name: attachment of spindle microtubules to kinetochore during meiosis II namespace: biological_process def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt] xref: GO:0051456 is_a: CCO:P0000311 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation relationship: part_of CCO:P0000240 ! meiotic sister chromatid segregation [Term] id: CCO:P0000344 name: activation of anaphase-promoting complex during meiotic cell cycle namespace: biological_process def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex during the meiotic cell cycle." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297] synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" EXACT [] synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" EXACT [] synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" EXACT [] synonym: "anaphase promoting complex activation during meiotic cell cycle" EXACT [] synonym: "anaphase-promoting complex activation during meiotic cell cycle" EXACT [] synonym: "APC activation during meiotic cell cycle" EXACT [] synonym: "meiotic anaphase promoting complex activation" EXACT [] synonym: "meiotic anaphase promoting complex activator" NARROW [] synonym: "meiotic anaphase-promoting complex activator" NARROW [] synonym: "meiotic APC activation" EXACT [] synonym: "meiotic APC activator" NARROW [] xref: GO:0051487 is_a: CCO:P0000337 ! positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle [Term] id: CCO:P0000345 name: meiotic recombination checkpoint namespace: biological_process def: "A checkpoint during late prophase I (pachytene) which prevents segregation of homologous chromosomes until recombination is completed and ensures proper distribution of the genetic material to the gametes." [PMID:14718568] synonym: "pachytene checkpoint" EXACT [] xref: GO:0051598 is_a: CCO:P0000219 ! meiotic cell cycle checkpoint is_a: CCO:P0000248 ! negative regulation of meiosis relationship: part_of CCO:P0000119 ! meiotic prophase I [Term] id: CCO:P0000346 name: regulation of cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "cell cycle control" EXACT [] synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] xref: GO:0000074 xref: GO:0051726 xref: Reactome:156678 xref: Reactome:156699 xref: Reactome:156711 xref: Reactome:162657 xref: Reactome:204139 xref: Reactome:209045 xref: Reactome:209050 xref: Reactome:211608 xref: Reactome:213123 xref: Reactome:218715 xref: Reactome:218726 xref: Reactome:221382 xref: Reactome:222877 xref: Reactome:227596 xref: Reactome:230018 xref: Reactome:235842 xref: Reactome:235853 xref: Reactome:238231 xref: Reactome:239383 xref: Reactome:243028 xref: Reactome:243033 xref: Reactome:244651 xref: Reactome:245640 xref: Reactome:248176 xref: Reactome:248181 xref: Reactome:249585 xref: Reactome:250281 xref: Reactome:251600 xref: Reactome:252387 xref: Reactome:253031 xref: Reactome:254679 xref: Reactome:255542 xref: Reactome:256281 xref: Reactome:257921 xref: Reactome:258917 xref: Reactome:259656 xref: Reactome:261512 xref: Reactome:262291 xref: Reactome:264389 xref: Reactome:265239 xref: Reactome:267430 xref: Reactome:267435 xref: Reactome:268364 xref: Reactome:280849 xref: Reactome:282764 xref: Reactome:285431 xref: Reactome:285436 xref: Reactome:286566 is_a: CCO:U0000002 ! biological process relationship: has_participant CCO:B0001485 ! INHA_HUMAN relationship: has_participant CCO:B0001499 ! CD45_HUMAN relationship: has_participant CCO:B0001994 ! CABL1_HUMAN relationship: has_participant CCO:B0002010 ! MADD_HUMAN relationship: has_participant CCO:B0002054 ! UHRF2_HUMAN relationship: has_participant CCO:B0002097 ! CABL2_HUMAN relationship: regulates CCO:P0000066 ! cell cycle [Term] id: CCO:P0000347 name: cell cycle switching, meiotic to mitotic cell cycle namespace: biological_process def: "The process by which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai] synonym: "cell cycle switching, meiotis to mitosis" NARROW [] synonym: "conversion to mitosis" NARROW [] synonym: "conversion to mitotic cell cycle" EXACT [] synonym: "entry into mitosis" NARROW [] synonym: "entry into mitotic cell cycle" EXACT [] synonym: "initiation of mitosis" NARROW [] synonym: "initiation of mitotic cell cycle" EXACT [] synonym: "mitotic entry" NARROW [] xref: GO:0051727 is_a: CCO:P0000361 ! cell cycle switching [Term] id: CCO:P0000348 name: cell cycle switching, mitotic to meiotic cell cycle namespace: biological_process def: "The process by which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai] synonym: "cell cycle switching, mitotis to meiosis" NARROW [] synonym: "conversion to meiosis" NARROW [] synonym: "conversion to meiotic cell cycle" EXACT [] synonym: "entry into meiosis" NARROW [] synonym: "entry into meiotic cell cycle" EXACT [] synonym: "initiation of meiosis" NARROW [] synonym: "initiation of meiotic cell cycle" EXACT [] synonym: "meiotic entry" NARROW [] xref: GO:0042061 xref: GO:0051728 is_a: CCO:P0000361 ! cell cycle switching [Term] id: CCO:P0000349 name: germline cell cycle switching, mitotic to meiotic cell cycle namespace: biological_process def: "The process by which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai] synonym: "germline cell cycle switching, mitotis to meiosis" NARROW [] synonym: "germline conversion to meiosis" NARROW [] synonym: "germline conversion to meiotic cell cycle" EXACT [] synonym: "germline entry into meiosis" NARROW [] synonym: "germline entry into meiotic cell cycle" EXACT [] synonym: "germline initiation of meiosis" NARROW [] synonym: "germline initiation of meiotic cell cycle" EXACT [] synonym: "germline meiotic entry" NARROW [] xref: GO:0051729 is_a: CCO:P0000348 ! cell cycle switching, mitotic to meiotic cell cycle [Term] id: CCO:P0000350 name: meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "The cell cycle process whereby centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576] synonym: "meiotic sister chromatid cohesion at centromere" EXACT [] synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT [] xref: GO:0051754 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000289 ! meiotic sister chromatid cohesion [Term] id: CCO:P0000351 name: meiotic sister chromatid arm separation namespace: biological_process def: "The cell cycle process whereby sister chromatid arms are physically detached from each other during meiosis." [GOC:ai] xref: GO:0051755 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000118 ! meiosis I relationship: part_of CCO:P0000353 ! meiotic sister chromatid separation [Term] id: CCO:P0000352 name: meiotic sister chromatid centromere separation namespace: biological_process def: "The cell cycle process whereby the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] xref: GO:0051756 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000240 ! meiotic sister chromatid segregation relationship: part_of CCO:P0000353 ! meiotic sister chromatid separation [Term] id: CCO:P0000353 name: meiotic sister chromatid separation namespace: biological_process def: "The process by which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] xref: GO:0051757 is_a: CCO:P0000305 ! meiotic chromosome separation [Term] id: CCO:P0000354 name: homologous chromosome movement towards spindle pole during meiosis I namespace: biological_process def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I." [GOC:ai] synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT [] xref: GO:0051758 is_a: CCO:P0000155 ! meiotic chromosome movement towards spindle pole relationship: part_of CCO:P0000239 ! homologous chromosome segregation [Term] id: CCO:P0000355 name: sister chromosome movement towards spindle pole during meiosis II namespace: biological_process def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai] synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT [] xref: GO:0051759 is_a: CCO:P0000155 ! meiotic chromosome movement towards spindle pole relationship: part_of CCO:P0000240 ! meiotic sister chromatid segregation [Term] id: CCO:P0000356 name: meiotic sister chromatid cohesion, arms namespace: biological_process def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576] synonym: "meiotic sister chromatid cohesion along arms" EXACT [] synonym: "sister chromatid cohesion along arms at meiosis I" EXACT [] xref: GO:0051760 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000289 ! meiotic sister chromatid cohesion [Term] id: CCO:P0000357 name: lateral element assembly namespace: biological_process def: "The cell cycle process whereby lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847] xref: GO:0051878 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000121 ! synaptonemal complex assembly [Term] id: CCO:P0000358 name: generative cell mitosis namespace: biological_process def: "The process whereby the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells." [GOC:mtg_plant] xref: GO:0055047 is_a: CCO:P0000081 ! mitosis [Term] id: CCO:P0000359 name: viral process regulating host cell cycle namespace: biological_process def: "Any viral process that modulates the rate or extent of progression through the cell cycle." [GOC:dph] xref: GO:0060153 is_a: CCO:P0000346 ! regulation of cell cycle [Term] id: CCO:P0000360 name: cellular process regulating host cell cycle in response to virus namespace: biological_process def: "Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus." [GOC:dph] xref: GO:0060154 is_a: CCO:P0000346 ! regulation of cell cycle [Term] id: CCO:P0000361 name: cell cycle switching namespace: biological_process def: "The process by which a cell switches cell cycle mode." [GOC:dph, GOC:kmv, GOC:tb] xref: GO:0060184 is_a: CCO:P0000159 ! cell cycle process [Term] id: CCO:P0000362 name: plant-type spore development namespace: biological_process def: "The process whose specific outcome is the progression of the spore over time, from its formation to the mature structure. The spore gives rise to gametophytes." [GOC:jic, http://www.m-w.com] synonym: "plant spore development" EXACT [] synonym: "spore development (sensu Magnoliophyta)" EXACT [] xref: GO:0048236 is_a: CCO:P0000117 ! meiosis [Term] id: CCO:P0000363 name: negative regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] xref: GO:0010503 is_a: CCO:P0000364 ! regulation of cell cycle arrest in response to nitrogen starvation relationship: negatively_regulates CCO:P0000166 ! cell cycle arrest in response to nitrogen starvation [Term] id: CCO:P0000364 name: regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] xref: GO:0010504 is_a: CCO:P0000382 ! regulation of cell cycle process relationship: regulates CCO:P0000166 ! cell cycle arrest in response to nitrogen starvation [Term] id: CCO:P0000365 name: positive regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] xref: GO:0010505 is_a: CCO:P0000364 ! regulation of cell cycle arrest in response to nitrogen starvation relationship: positively_regulates CCO:P0000166 ! cell cycle arrest in response to nitrogen starvation [Term] id: CCO:P0000366 name: establishment of sister chromatid cohesion namespace: biological_process def: "The process by which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase." [GOC:mah, PMID:14623866] xref: GO:0034085 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000076 ! sister chromatid cohesion [Term] id: CCO:P0000367 name: maintenance of sister chromatid cohesion namespace: biological_process def: "The process by which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate." [GOC:mah, PMID:14623866] xref: GO:0034086 is_a: CCO:P0000159 ! cell cycle process relationship: part_of CCO:P0000076 ! sister chromatid cohesion [Term] id: CCO:P0000368 name: establishment of mitotic sister chromatid cohesion namespace: biological_process def: "The process by which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle." [GOC:mah] xref: GO:0034087 is_a: CCO:P0000366 ! establishment of sister chromatid cohesion relationship: part_of CCO:P0000078 ! mitotic sister chromatid cohesion [Term] id: CCO:P0000369 name: maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "The process by which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah] synonym: "mitotic cohesion stability" RELATED [] xref: GO:0034088 is_a: CCO:P0000367 ! maintenance of sister chromatid cohesion relationship: part_of CCO:P0000078 ! mitotic sister chromatid cohesion [Term] id: CCO:P0000370 name: establishment of meiotic sister chromatid cohesion namespace: biological_process def: "The process by which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle." [GOC:mah] xref: GO:0034089 is_a: CCO:P0000366 ! establishment of sister chromatid cohesion relationship: part_of CCO:P0000289 ! meiotic sister chromatid cohesion [Term] id: CCO:P0000371 name: maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "The process by which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:mah] xref: GO:0034090 is_a: CCO:P0000367 ! maintenance of sister chromatid cohesion relationship: part_of CCO:P0000289 ! meiotic sister chromatid cohesion [Term] id: CCO:P0000372 name: regulation of maintenance of sister chromatid cohesion namespace: biological_process def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] xref: GO:0034091 is_a: CCO:P0000077 ! regulation of sister chromatid cohesion relationship: regulates CCO:P0000367 ! maintenance of sister chromatid cohesion [Term] id: CCO:P0000373 name: negative regulation of maintenance of sister chromatid cohesion namespace: biological_process def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] xref: GO:0034092 is_a: CCO:P0000254 ! negative regulation of sister chromatid cohesion is_a: CCO:P0000372 ! regulation of maintenance of sister chromatid cohesion relationship: negatively_regulates CCO:P0000367 ! maintenance of sister chromatid cohesion [Term] id: CCO:P0000374 name: positive regulation of maintenance of sister chromatid cohesion namespace: biological_process def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] xref: GO:0034093 is_a: CCO:P0000255 ! positive regulation of sister chromatid cohesion is_a: CCO:P0000372 ! regulation of maintenance of sister chromatid cohesion relationship: positively_regulates CCO:P0000367 ! maintenance of sister chromatid cohesion [Term] id: CCO:P0000375 name: regulation of maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] xref: GO:0034094 is_a: CCO:P0000372 ! regulation of maintenance of sister chromatid cohesion relationship: regulates CCO:P0000371 ! maintenance of meiotic sister chromatid cohesion [Term] id: CCO:P0000376 name: negative regulation of maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] xref: GO:0034095 is_a: CCO:P0000373 ! negative regulation of maintenance of sister chromatid cohesion is_a: CCO:P0000375 ! regulation of maintenance of meiotic sister chromatid cohesion relationship: negatively_regulates CCO:P0000371 ! maintenance of meiotic sister chromatid cohesion [Term] id: CCO:P0000377 name: positive regulation of maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] xref: GO:0034096 is_a: CCO:P0000374 ! positive regulation of maintenance of sister chromatid cohesion is_a: CCO:P0000375 ! regulation of maintenance of meiotic sister chromatid cohesion relationship: positively_regulates CCO:P0000371 ! maintenance of meiotic sister chromatid cohesion [Term] id: CCO:P0000378 name: regulation of maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] xref: GO:0034182 is_a: CCO:P0000372 ! regulation of maintenance of sister chromatid cohesion relationship: regulates CCO:P0000369 ! maintenance of mitotic sister chromatid cohesion [Term] id: CCO:P0000379 name: negative regulation of maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] xref: GO:0034183 is_a: CCO:P0000373 ! negative regulation of maintenance of sister chromatid cohesion is_a: CCO:P0000378 ! regulation of maintenance of mitotic sister chromatid cohesion relationship: negatively_regulates CCO:P0000369 ! maintenance of mitotic sister chromatid cohesion [Term] id: CCO:P0000380 name: positive regulation of maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] xref: GO:0034184 is_a: CCO:P0000374 ! positive regulation of maintenance of sister chromatid cohesion is_a: CCO:P0000378 ! regulation of maintenance of mitotic sister chromatid cohesion relationship: positively_regulates CCO:P0000369 ! maintenance of mitotic sister chromatid cohesion [Term] id: CCO:P0000381 name: regulation of meiotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of recombination during meiosis." [GOC:dph, GOC:tb] xref: GO:0010520 is_a: CCO:P0000226 ! regulation of meiosis relationship: regulates CCO:P0000122 ! meiotic recombination [Term] id: CCO:P0000382 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] xref: GO:0010564 is_a: CCO:U0000002 ! biological process relationship: regulates CCO:P0000159 ! cell cycle process [Term] id: CCO:P0000383 name: positive regulation of DNA replication during S phase namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA replication during progression through S phase of the cell cycle." [GOC:dph, GOC:jp, GOC:tb] xref: GO:0010571 is_a: CCO:P0000216 ! regulation of DNA replication during S phase relationship: positively_regulates CCO:P0000214 ! DNA replication during S phase [Term] id: CCO:P0000384 name: regulation of mitotic spindle organization and biogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the microtubule spindle during a mitotic cell cycle." [GOC:dph, GOC:tb] xref: GO:0060236 is_a: CCO:P0000382 ! regulation of cell cycle process relationship: regulates CCO:P0000068 ! mitotic spindle organization and biogenesis [Term] id: CCO:R0000000 name: biological reference is_a: CCO:U0000001 ! biological continuant [Term] id: CCO:R0000001 name: AgBase def: "AgBase resource for functional analysis of agricultural plant and animal gene products" [] comment: http://www.agbase.msstate.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000002 name: AGI_LocusCode def: "Arabidopsis Genome Initiative (TAIR, TIGR, MIPS)" [] comment: http://www.arabidopsis.org is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000003 name: AGRICOLA_bib def: "AGRICultural OnLine Access" [] comment: http://agricola.nal.usda.gov/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000004 name: AGRICOLA_IND def: "AGRICultural OnLine Access" [] comment: http://agricola.cos.com/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000005 name: AGRICOLA_NAL def: "AGRICultural OnLine Access" [] comment: http://agricola.nal.usda.gov/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000006 name: ApiDB_PlasmoDB def: "PlasmoDB Plasmodium Genome Resource" [] comment: http://plasmodb.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000007 name: AraCyc def: "AraCyc metabolic pathway database for Arabidopsis thaliana" [] comment: http://www.arabidopsis.org/biocyc/index.jsp is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000008 name: BHF-UCL def: "Cardiovascular Gene Ontology Annotation Initiative; supported by the British Heart Foundation (BHF) at University College London (UCL)" [] comment: http://www.ucl.ac.uk/medicine/cardiovascular-genetics/geneontology.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000009 name: BIOMD def: "BioModels Database" [] comment: http://www.ebi.ac.uk/biomodels/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000010 name: BIOSIS def: "BIOSIS previews" [] comment: http://www.biosis.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000011 name: BRENDA def: "BRENDA, The Comprehensive Enzyme Information System" [] comment: http://www.brenda.uni-koeln.de/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000012 name: Broad def: "Broad Institute" [] comment: http://www.broad.mit.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000013 name: Broad_MGG def: "Magnaporthe grisea Database at the Broad Institute" [] comment: http://www.broad.mit.edu/annotation/genome/magnaporthe_grisea/Home.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000014 name: CBS def: "Center for Biological Sequence Analysis" [] comment: http://www.cbs.dtu.dk/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000015 name: CDD def: "Conserved Domain Database at NCBI" [] comment: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=cdd is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000016 name: CGD def: "Candida Genome Database" [] comment: http://www.candidagenome.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000017 name: CGD_LOCUS def: "Candida Genome Database" [] comment: http://www.candidagenome.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000018 name: CGD_REF def: "Candida Genome Database" [] comment: http://www.candidagenome.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000019 name: CGEN def: "Compugen Gene Ontology Gene Association Data" [] comment: http://www.cgen.com/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000020 name: CGSC def: "CGSC: E.coli Genetic Stock Center" [] comment: http://cgsc.biology.yale.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000021 name: ChEBI def: "Chemical Entities of Biological Interest" [] comment: http://www.ebi.ac.uk/chebi/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000022 name: CL def: "Cell Type Ontology" [] comment: https://lists.sourceforge.net/lists/listinfo/obo-cell-type is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000023 name: COG def: "NCBI Clusters of Orthologous Groups" [] comment: http://www.ncbi.nlm.nih.gov/COG/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000024 name: COG_Cluster def: "NCBI COG cluster" [] comment: http://www.ncbi.nlm.nih.gov/COG/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000025 name: COG_Function def: "NCBI COG function" [] comment: http://www.ncbi.nlm.nih.gov/COG/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000026 name: COG_Pathway def: "NCBI COG pathway" [] comment: http://www.ncbi.nlm.nih.gov/COG/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000030 name: DOI def: "Digital Object Identifier" [] comment: http://www.doi.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000031 name: EC def: "The Enzyme Commission" [] comment: www.chem.qmul.ac.uk/iubmb/enzyme/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000032 name: EchoBASE def: "EchoBASE post-genomic database for Escherichia coli" [] comment: http://www.ecoli-york.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000033 name: ECK def: "The EcoGene Database of Escherichia coli Sequence and Function" [] comment: http://www.ecogene.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000034 name: EcoCyc def: "The Encyclopedia of E. coli metabolism" [] comment: http://ecocyc.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000035 name: ECOGENE def: "The EcoGene Database of Escherichia coli Sequence and Function" [] comment: http://www.ecogene.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000036 name: ECOGENE_G def: "The EcoGene Database of Escherichia coli Sequence and Function" [] comment: http://www.ecogene.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000037 name: EMBL def: "International Nucleotide Sequence Database Collaboration, comprising EMBL-EBI International Nucleotide Sequence Data Library (EMBL-Bank), DNA DataBank of Japan (DDBJ), and NCBI GenBank" [] comment: http://www.ncbi.nlm.nih.gov/Genbank/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000038 name: ENSEMBL def: "Database of automatically annotated genomic data" [] comment: http://www.ensembl.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000039 name: ENZYME def: "The Swiss Institute of Bioinformatics database of Enzymes" [] comment: http://www.expasy.ch/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000040 name: FB def: "FlyBase" [] comment: http://flybase.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000041 name: FLYBASE def: "FlyBase" [] comment: http://flybase.bio.indiana.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000042 name: GDB def: "Human Genome Database" [] comment: http://www.gdb.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000043 name: GeneDB_Gmorsitans def: "GeneDB_Gmorsitans" [] comment: http://www.genedb.org/genedb/glossina/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000044 name: GeneDB_Lmajor def: "GeneDB_Lmajor" [] comment: http://www.genedb.org/genedb/leish/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000045 name: GeneDB_Pfalciparum def: "GeneDB_Pfalciparum" [] comment: http://www.genedb.org/genedb/malaria/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000046 name: GeneDB_Spombe def: "GeneDB_Spombe" [] comment: http://www.genedb.org/genedb/pombe/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000047 name: GeneDB_Tbrucei def: "GeneDB_Tbrucei" [] comment: http://www.genedb.org/genedb/tryp/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000048 name: GenProtEC def: "GenProtEC E. coli genome and proteome database" [] comment: http://genprotec.mbl.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000049 name: GermOnline def: "GermOnline" [] comment: http://www.germonline.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000050 name: GO def: "Gene Ontology Database" [] comment: http://amigo.geneontology.org/cgi-bin/amigo/go.cgi is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000051 name: GO_REF def: "Gene Ontology Database references" [] is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000052 name: GOA def: "GO Annotation at EBI" [] comment: http://www.ebi.ac.uk/goa/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000053 name: GOC def: "Gene Ontology Consortium" [] comment: http://www.geneontology.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000054 name: GR def: "Gramene: A Comparative Mapping Resource for Grains" [] comment: http://www.gramene.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000055 name: GR_GENE def: "Gramene: A Comparative Mapping Resource for Grains" [] comment: http://www.gramene.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000056 name: GR_PROTEIN def: "Gramene: A Comparative Mapping Resource for Grains" [] comment: http://www.gramene.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000057 name: GR_QTL def: "Gramene: A Comparative Mapping Resource for Grains" [] comment: http://www.gramene.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000058 name: GR_REF def: "Gramene: A Comparative Mapping Resource for Grains" [] comment: http://www.gramene.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000059 name: H-invDB def: "H-invitational Database" [] comment: http://www.h-invitational.jp/ is_a: CCO:R0000000 ! 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biological reference [Term] id: CCO:R0000067 name: IMGT_HLA def: "Immunogenetics database, human MHC" [] comment: http://www.ebi.ac.uk/imgt/hla is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000068 name: IMGT_LIGM def: "Immunogenetics database, immunoglobulins and T-cell receptors" [] comment: http://imgt.cines.fr is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000069 name: IntAct def: "IntAct protein interaction database" [] comment: http://www.ebi.ac.uk/intact/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000070 name: InterPro def: "The InterPro database of protein domains and motifs" [] comment: http://www.ebi.ac.uk/interpro/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000071 name: IPI def: "International Protein Index" [] comment: http://www.ebi.ac.uk/IPI/IPIhelp.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000072 name: ISBN def: "International Standard Book Number" [] comment: http://isbntools.com/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000073 name: ISSN def: "International Standard Serial Number" [] comment: http://www.issn.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000074 name: IUPHAR def: "The IUPHAR Compendium of Receptor Characterization and Classification" [] is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000075 name: KEGG def: "Kyoto Encyclopedia of Genes and Genomes" [] comment: http://www.genome.ad.jp/kegg/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000076 name: KEGG_PATHWAY def: "KEGG Pathways Database" [] comment: http://www.genome.ad.jp/kegg/docs/upd_pathway.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000077 name: LIFEdb def: "LIFEdb, a database for the integration and dissemination of functional data" [] comment: http://www.lifedb.de/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000078 name: LIGAND def: "KEGG LIGAND Database" [] comment: http://www.genome.ad.jp/kegg/docs/upd_ligand.html#COMPOUND is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000079 name: LOCSVMpsi def: "LOCSVMPSI: subcellular localization for eukayotic proteins based on SVM and PSI-BLAST" [] comment: http://bioinformatics.ustc.edu.cn/locsvmpsi/locsvmpsi.php is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000080 name: MA def: "Adult Mouse Anatomical Dictionary; part of Gene Expression Database" [] comment: http://www.informatics.jax.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000081 name: MaizeGDB def: "MaizeGDB" [] comment: http://www.maizegdb.org is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000082 name: MaizeGDB_Locus def: "MaizeGDB" [] comment: http://www.maizegdb.org is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000083 name: MEDLINE def: "The Medline literature database" [] is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000084 name: MEROPS def: "MEROPS - the Peptidase Database" [] comment: http://merops.sanger.ac.uk/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000085 name: MEROPS_fam def: "MEROPS: The Peptidase Database" [] comment: http://merops.sanger.ac.uk/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000086 name: MeSH def: "Medical Subject Headings " [] comment: http://www.nlm.nih.gov/mesh/2005/MBrowser.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000087 name: MetaCyc def: "The Metabolic Encyclopedia of metabolic and other pathways" [] comment: http://metacyc.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000088 name: MGD def: "Mouse Genome Database" [] comment: http://www.informatics.jax.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000089 name: MGI def: "Mouse Genome Informatics" [] comment: http://www.informatics.jax.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000090 name: MIPS_funcat def: "MIPS Functional Catalogue" [] comment: http://mips.gsf.de/proj/funcatDB/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000091 name: MO def: "The MGED Ontology" [] comment: http://mged.sourceforge.net/ontologies/MGEDontology.php is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000092 name: MultiFun def: "MultiFun, a cellfunction assignment schema" [] comment: http://genprotec.mbl.edu/files/Multifun.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000093 name: NASC_code def: "Nottingham Arabidopsis Stock Centre Seeds Database" [] comment: http://arabidopsis.info is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000094 name: NC-IUBMB def: "Nomenclature Committee of the International Union of Biochemistry and Molecular Biology" [] comment: http://www.chem.qmw.ac.uk/iubmb/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000095 name: NCBI def: "National Center for Biotechnology Information, Bethesda" [] comment: http://www.ncbi.nlm.nih.gov/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000096 name: NCBI_Gene def: "NCBI Gene" [] comment: http://www.ncbi.nlm.nih.gov/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000097 name: NCBI_gi def: "NCBI databases" [] comment: http://www.ncbi.nlm.nih.gov/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000098 name: NCBI_GP def: "NCBI GenPept" [] comment: http://www.ncbi.nlm.nih.gov/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000099 name: NCBI_NM def: "NCBI RefSeq" [] comment: http://www.ncbi.nlm.nih.gov/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000100 name: NCBI_NP def: "NCBI RefSeq" [] comment: http://www.ncbi.nlm.nih.gov/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000101 name: NMPDR def: "National Microbial Pathogen Data Resource" [] comment: http://www.nmpdr.org is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000102 name: OMIM def: "Mendelian Inheritance in Man" [] comment: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000103 name: PAMGO def: "Plant-Associated Microbe Gene Ontology Interest Group" [] comment: http://pamgo.vbi.vt.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000104 name: PAMGO_GAT def: "Genome Annotation Tool (Agrobacterium tumefaciens C58); PAMGO Interest Group" [] comment: http://agro.vbi.vt.edu/public/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000105 name: PAMGO_MGG def: "Magnaporthe grisea Database at North Carolina State University; member of PAMGO Interest Group" [] comment: http://scotland.fgl.ncsu.edu/smeng/GoAnnotationMagnaporthegrisea.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000106 name: PAMGO_VMD def: "Virginia Bioinformatics Institute Microbial Database; member of PAMGO Interest Group" [] comment: http://phytophthora.vbi.vt.edu is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000107 name: PANTHER def: "Protein ANalysis THrough Evolutionary Relationships Classification System" [] comment: http://www.pantherdb.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000108 name: PATO def: "Phenotypic quality ontology" [] comment: http://www.bioontology.org/wiki/index.php/PATO:Main_Page is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000109 name: PDB def: "Protein Data Bank" [] comment: http://www.rcsb.org/pdb/ is_a: CCO:R0000000 ! 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biological reference [Term] id: CCO:R0000174 name: TrEMBL def: "UniProtKB-TrEMBL, a computer-annotated protein sequence database supplementing UniProtKB and containing the translations of all coding sequences (CDS) present in the EMBL Nucleotide Sequence Database but not yet integrated in UniProtKB/Swiss-Prot" [] comment: http://www.uniprot.org is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000175 name: UM-BBD def: "The University of Minnesota Biocatalysis/Biodegradation Database" [] comment: http://umbbd.msi.umn.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000176 name: UM-BBD_enzymeID def: "The University of Minnesota Biocatalysis/Biodegradation Database" [] comment: http://umbbd.msi.umn.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000177 name: UM-BBD_pathwayID def: "The University of Minnesota Biocatalysis/Biodegradation Database" [] comment: http://umbbd.msi.umn.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000178 name: UniParc def: "UniProt Archive; a non-redundant archive of protein sequences extracted from Swiss-Prot, TrEMBL, PIR-PSD, EMBL, Ensembl, IPI, PDB, RefSeq, FlyBase, WormBase, European Patent Office, United States Patent and Trademark Office, and Japanese Patent Office" [] comment: http://www.ebi.ac.uk/uniparc/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000179 name: UniProtKB def: "The Universal Protein Knowledgebase, a central repository of protein sequence and function created by joining the information contained in Swiss-Prot, TrEMBL, and PIR" [] comment: http://www.uniprot.org is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000180 name: VEGA def: "The Vertebrate Genome Annotation database" [] comment: http://vega.sanger.ac.uk/index.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000181 name: VIDA def: "Virus Database at University College London" [] comment: http://www.biochem.ucl.ac.uk/bsm/virus_database/VIDA.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000182 name: VMD def: "Virginia Bioinformatics Institute Microbial Database" [] comment: http://phytophthora.vbi.vt.edu is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000183 name: WB def: "WormBase, database of nematode biology" [] comment: http://www.wormbase.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000184 name: WB_GENE def: "WormBase, database of nematode biology" [] comment: http://www.wormbase.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000185 name: WB_REF def: "WormBase, database of nematode biology" [] comment: http://www.wormbase.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000186 name: WP def: "Wormpep, database of proteins of C. elegans" [] comment: http://www.wormbase.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000187 name: ZFIN def: "The Zebrafish Information Network" [] comment: http://zfin.org/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000188 name: http is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000189 name: dictyBase def: "dictyBase" [] comment: http://dictybase.org is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000190 name: dictyBase_gene_name def: "dictyBase" [] comment: http://dictybase.org is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000191 name: dictyBase_REF def: "dictyBase literature references" [] comment: http://dictybase.org is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000192 name: Gene3D def: "Domain Architecture Classification" [] comment: http://gene3d.biochem.ucl.ac.uk/Gene3D/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000193 name: SUPERFAMILY def: "SUPERFAMILY. A database of structural and functional protein annotations for completely sequenced genomes" [] comment: http://supfam.mrc-lmb.cam.ac.uk/SUPERFAMILY/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000194 name: CASGEN def: "Catalog of Fishes genus database" [] comment: http://research.calacademy.org/research/ichthyology/catalog/fishcatsearch.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000195 name: CASSPC def: "Catalog of Fishes species database" [] comment: http://research.calacademy.org/research/ichthyology/catalog/fishcatsearch.html is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000196 name: SGN def: "Sol Genomics Network" [] comment: http://www.sgn.cornell.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000197 name: EcoliWiki def: "EcoliWiki, EcoliHub's subsystem for community annotation of E. coli K-12" [] comment: http://ecoliwiki.net/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000198 name: SGN_ref def: "Sol Genomics Network" [] comment: http://www.sgn.cornell.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000199 name: UM-BBD_reactionID def: "The University of Minnesota Biocatalysis/Biodegradation Database" [] comment: http://umbbd.msi.umn.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:R0000200 name: UM-BBD_ruleID def: "The University of Minnesota Biocatalysis/Biodegradation Database" [] comment: http://umbbd.msi.umn.edu/ is_a: CCO:R0000000 ! biological reference [Term] id: CCO:T0000001 name: Tetrapoda organism xref: NCBI:32523 is_a: CCO:T0000051 ! Sarcopterygii organism [Term] id: CCO:T0000002 name: Ascomycota organism xref: NCBI:4890 is_a: CCO:T0000024 ! Dikarya organism [Term] id: CCO:T0000003 name: Theria organism xref: NCBI:32525 is_a: CCO:T0000057 ! Mammalia organism [Term] id: CCO:T0000004 name: Homo sapiens organism xref: NCBI:9606 is_a: CCO:T0000054 ! Homo organism [Term] id: CCO:T0000005 name: Coelomata organism xref: NCBI:33316 is_a: CCO:T0000036 ! Bilateria organism [Term] id: CCO:T0000006 name: Euteleostomi organism xref: NCBI:117571 is_a: CCO:T0000027 ! Teleostomi organism [Term] id: CCO:T0000007 name: rosids organism xref: NCBI:71275 is_a: CCO:T0000038 ! core eudicotyledons organism [Term] id: CCO:T0000008 name: Schizosaccharomyces organism xref: NCBI:4895 is_a: CCO:T0000056 ! Schizosaccharomycetaceae organism [Term] id: CCO:T0000009 name: Streptophyta organism xref: NCBI:35493 is_a: CCO:T0000012 ! Viridiplantae organism [Term] id: CCO:T0000010 name: Magnoliophyta organism xref: NCBI:3398 is_a: CCO:T0000032 ! Spermatophyta organism [Term] id: CCO:T0000011 name: organism xref: NCBI:1 is_a: CCO:U0000001 ! biological continuant [Term] id: CCO:T0000012 name: Viridiplantae organism xref: NCBI:33090 is_a: CCO:T0000033 ! Eukaryota organism [Term] id: CCO:T0000013 name: Schizosaccharomycetales organism xref: NCBI:34346 is_a: CCO:T0000025 ! Schizosaccharomycetes organism [Term] id: CCO:T0000014 name: Saccharomycetales organism xref: NCBI:4892 is_a: CCO:T0000040 ! Saccharomycetes organism [Term] id: CCO:T0000015 name: eudicotyledons organism xref: NCBI:71240 is_a: CCO:T0000010 ! Magnoliophyta organism [Term] id: CCO:T0000016 name: Saccharomyces cerevisiae organism xref: NCBI:4932 is_a: CCO:T0000019 ! Saccharomyces organism [Term] id: CCO:T0000017 name: Schizosaccharomyces pombe organism xref: NCBI:4896 is_a: CCO:T0000008 ! Schizosaccharomyces organism [Term] id: CCO:T0000018 name: Euphyllophyta organism xref: NCBI:78536 is_a: CCO:T0000031 ! Tracheophyta organism [Term] id: CCO:T0000019 name: Saccharomyces organism xref: NCBI:4930 is_a: CCO:T0000035 ! Saccharomycetaceae organism [Term] id: CCO:T0000020 name: Metazoa organism xref: NCBI:33208 is_a: CCO:T0000042 ! Fungi/Metazoa group organism [Term] id: CCO:T0000021 name: Homo/Pan/Gorilla group organism xref: NCBI:207598 is_a: CCO:T0000060 ! Hominidae organism [Term] id: CCO:T0000022 name: Brassicales organism xref: NCBI:3699 is_a: CCO:T0000062 ! eurosids II organism [Term] id: CCO:T0000023 name: Embryophyta organism xref: NCBI:3193 is_a: CCO:T0000053 ! Streptophytina organism [Term] id: CCO:T0000024 name: Dikarya organism xref: NCBI:451864 is_a: CCO:T0000026 ! Fungi organism [Term] id: CCO:T0000025 name: Schizosaccharomycetes organism xref: NCBI:147554 is_a: CCO:T0000052 ! Taphrinomycotina organism [Term] id: CCO:T0000026 name: Fungi organism xref: NCBI:4751 is_a: CCO:T0000042 ! Fungi/Metazoa group organism [Term] id: CCO:T0000027 name: Teleostomi organism xref: NCBI:117570 is_a: CCO:T0000050 ! Gnathostomata organism [Term] id: CCO:T0000028 name: Brassicaceae organism xref: NCBI:3700 is_a: CCO:T0000022 ! Brassicales organism [Term] id: CCO:T0000029 name: Primates organism xref: NCBI:9443 is_a: CCO:T0000055 ! Euarchontoglires organism [Term] id: CCO:T0000030 name: Hominoidea organism xref: NCBI:314295 is_a: CCO:T0000047 ! Catarrhini organism [Term] id: CCO:T0000031 name: Tracheophyta organism xref: NCBI:58023 is_a: CCO:T0000023 ! Embryophyta organism [Term] id: CCO:T0000032 name: Spermatophyta organism xref: NCBI:58024 is_a: CCO:T0000018 ! Euphyllophyta organism [Term] id: CCO:T0000033 name: Eukaryota organism xref: NCBI:2759 is_a: CCO:T0000041 ! cellular organisms organism [Term] id: CCO:T0000034 name: Arabidopsis thaliana organism xref: NCBI:3702 is_a: CCO:T0000059 ! Arabidopsis organism [Term] id: CCO:T0000035 name: Saccharomycetaceae organism xref: NCBI:4893 is_a: CCO:T0000014 ! Saccharomycetales organism [Term] id: CCO:T0000036 name: Bilateria organism xref: NCBI:33213 is_a: CCO:T0000049 ! Eumetazoa organism [Term] id: CCO:T0000037 name: Vertebrata organism xref: NCBI:7742 is_a: CCO:T0000045 ! Craniata organism [Term] id: CCO:T0000038 name: core eudicotyledons organism xref: NCBI:91827 is_a: CCO:T0000015 ! eudicotyledons organism [Term] id: CCO:T0000039 name: Saccharomycotina organism xref: NCBI:147537 is_a: CCO:T0000002 ! Ascomycota organism [Term] id: CCO:T0000040 name: Saccharomycetes organism xref: NCBI:4891 is_a: CCO:T0000039 ! Saccharomycotina organism [Term] id: CCO:T0000041 name: cellular organisms organism xref: NCBI:131567 is_a: CCO:T0000011 ! organism [Term] id: CCO:T0000042 name: Fungi/Metazoa group organism xref: NCBI:33154 is_a: CCO:T0000033 ! Eukaryota organism [Term] id: CCO:T0000043 name: Amniota organism xref: NCBI:32524 is_a: CCO:T0000001 ! Tetrapoda organism [Term] id: CCO:T0000044 name: Deuterostomia organism xref: NCBI:33511 is_a: CCO:T0000005 ! Coelomata organism [Term] id: CCO:T0000045 name: Craniata organism xref: NCBI:89593 is_a: CCO:T0000046 ! Chordata organism [Term] id: CCO:T0000046 name: Chordata organism xref: NCBI:7711 is_a: CCO:T0000044 ! Deuterostomia organism [Term] id: CCO:T0000047 name: Catarrhini organism xref: NCBI:9526 is_a: CCO:T0000048 ! Simiiformes organism [Term] id: CCO:T0000048 name: Simiiformes organism xref: NCBI:314293 is_a: CCO:T0000061 ! Haplorrhini organism [Term] id: CCO:T0000049 name: Eumetazoa organism xref: NCBI:6072 is_a: CCO:T0000020 ! Metazoa organism [Term] id: CCO:T0000050 name: Gnathostomata organism xref: NCBI:7776 is_a: CCO:T0000037 ! Vertebrata organism [Term] id: CCO:T0000051 name: Sarcopterygii organism xref: NCBI:8287 is_a: CCO:T0000006 ! Euteleostomi organism [Term] id: CCO:T0000052 name: Taphrinomycotina organism xref: NCBI:451866 is_a: CCO:T0000002 ! Ascomycota organism [Term] id: CCO:T0000053 name: Streptophytina organism xref: NCBI:131221 is_a: CCO:T0000009 ! Streptophyta organism [Term] id: CCO:T0000054 name: Homo organism xref: NCBI:9605 is_a: CCO:T0000021 ! Homo/Pan/Gorilla group organism [Term] id: CCO:T0000055 name: Euarchontoglires organism xref: NCBI:314146 is_a: CCO:T0000058 ! Eutheria organism [Term] id: CCO:T0000056 name: Schizosaccharomycetaceae organism xref: NCBI:4894 is_a: CCO:T0000013 ! Schizosaccharomycetales organism [Term] id: CCO:T0000057 name: Mammalia organism xref: NCBI:40674 is_a: CCO:T0000043 ! Amniota organism [Term] id: CCO:T0000058 name: Eutheria organism xref: NCBI:9347 is_a: CCO:T0000003 ! Theria organism [Term] id: CCO:T0000059 name: Arabidopsis organism xref: NCBI:3701 is_a: CCO:T0000028 ! Brassicaceae organism [Term] id: CCO:T0000060 name: Hominidae organism xref: NCBI:9604 is_a: CCO:T0000030 ! Hominoidea organism [Term] id: CCO:T0000061 name: Haplorrhini organism xref: NCBI:376913 is_a: CCO:T0000029 ! Primates organism [Term] id: CCO:T0000062 name: eurosids II organism xref: NCBI:91836 is_a: CCO:T0000007 ! rosids organism [Term] id: CCO:U0000000 name: biological entity def: "A biological process or continuant." [CCO:ea] synonym: "biological-entity" EXACT [CCO:ea] [Term] id: CCO:U0000001 name: biological continuant def: "Biological entities which endure, or continue to exist, through time while undergoing different sort of changes, including changes of place." [CCO:ea, PMID:15892874] synonym: "biological endurant" EXACT [PMID:15892874] synonym: "biological thing" BROAD [PMID:15892874] is_a: CCO:U0000000 ! biological entity [Term] id: CCO:U0000002 name: biological process def: "Biological entities that unfold themselves in successive temporal phases." [CCO:ea, PMID:15892874] synonym: "biological ocurrent" BROAD [PMID:15892874] synonym: "biological perdurant" EXACT [PMID:15892874] is_a: CCO:U0000000 ! biological entity disjoint_from: CCO:U0000001 [Term] id: CCO:U0000003 name: gene product def: "A gene product, such as a protein, or transcript, ocurring in, or formed by, living systems." [CCO:ea] is_a: CCO:U0000001 ! biological continuant [Term] id: CCO:U0000004 name: gene def: "Each of the units of heredity which (except for polygenes) may be regarded as the controlling agents in the expression of single phenotypic characters and are usually segments of a chromosome at fixed positions relative to each other." [CCO:ea, http://www.oed.com] is_a: CCO:U0000001 ! biological continuant [Term] id: CCO:U0000005 name: protein def: "Proteins are polymeric macromolecules composed of one or more long chains of amino acids linked by peptide bonds, usually coiled and folded into complex globular or fibrous structures." [CCO:ea, http://www.oed.com] is_a: CCO:U0000003 ! gene product [Term] id: CCO:U0000006 name: cell cycle continuant def: "Cell cycle entities which endure, or continue to exist, through time while undergoing different sort of changes, including changes of place." [CCO:ea] is_a: CCO:U0000001 ! biological continuant [Term] id: CCO:U0000007 name: cell cycle protein def: "Cell cycle proteins are polymeric macromolecules composed of one or more long chains of amino acids linked by peptide bonds, usually coiled and folded into complex globular or fibrous structures." [CCO:ea] is_a: CCO:U0000005 ! protein is_a: CCO:U0000006 ! cell cycle continuant [Term] id: CCO:U0000008 name: cell cycle gene def: "Cell cycle units of heredity which (except for polygenes) may be regarded as the controlling agents in the expression of single phenotypic characters and are usually segments of a chromosome at fixed positions relative to each other." [CCO:ea] is_a: CCO:U0000004 ! gene is_a: CCO:U0000006 ! cell cycle continuant [Term] id: CCO:U0000009 name: small molecule def: "A small structural unit of matter consisting of one or more atoms." [CCO:ea] is_a: CCO:U0000001 ! biological continuant [Term] id: CCO:U0000010 name: modified protein def: "A protein which underwent any sort of modification (e.g. phosphorylation)" [CCO:ea] is_a: CCO:U0000005 ! protein [Term] id: CCO:U0000011 name: cell cycle modified protein def: "A cell cycle protein which underwent any sort of modification (e.g. phosphorylation)" [CCO:ea] is_a: CCO:U0000007 ! cell cycle protein is_a: CCO:U0000010 ! modified protein [Term] id: CCO:Y0000001 name: interaction type def: "Connection between molecule." [PMID:14755292] subset: PSI-MI slim xref: MI:0190 is_a: CCO:U0000002 ! biological process [Term] id: CCO:Y0000002 name: acetylation reaction def: "Reaction, that can affect K,C,A,D,E,Q,G,I,K,M,P,S,T,Y,V residues." [GO:0006473, PMID:14755292, RESID:AA0041, RESID:AA0042, RESID:AA0043, RESID:AA0044, RESID:AA0045, RESID:AA0046, RESID:AA0047, RESID:AA0048, RESID:AA0049, RESID:AA0050, RESID:AA0051, RESID:AA0052, RESID:AA0053, RESID:AA0054, RESID:AA0055, RESID:AA0056] subset: PSI-MI slim synonym: "acetylation" EXACT PSI-MI-short [] xref: MI:0192 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000003 name: amidation reaction def: "Irreversible reaction that can affect A,R,N,D,C,Q,E,G,H,I,L,K,M,F,P,S,T,W,Y or V residues." [GO:0001519, PMID:14755292, RESID:AA0081, RESID:AA0082, RESID:AA0083, RESID:AA0084, RESID:AA0085, RESID:AA0086, RESID:AA0087, RESID:AA0088, RESID:AA0089, RESID:AA0090, RESID:AA0091, RESID:AA0092, RESID:AA0093, RESID:AA0094, RESID:AA0095, RESID:AA0096, RESID:AA0097, RESID:AA0098, RESID:AA0099, RESID:AA0100] subset: PSI-MI slim synonym: "amidation" EXACT PSI-MI-short [] xref: MI:0193 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000004 name: cleavage reaction def: "Covalent bond breakage in a molecule leading to the formation of smaller molecules." [PMID:14755292] subset: PSI-MI slim synonym: "cleavage" EXACT PSI-MI-short [] xref: MI:0194 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000005 name: covalent binding def: "Interaction leading to the formation of covalent bond within an autocatalytic molecule or between partners." [PMID:14755292] subset: PSI-MI slim xref: MI:0195 is_a: CCO:Y0000028 ! direct interaction [Term] id: CCO:Y0000006 name: deacetylation reaction def: "N6-acetyl-L-lysine or S-acetyl-L-cysteine are cleaved and return K or C residues." [GO:0006476, PMID:14755292, RESID:AA0055, RESID:AA0056] subset: PSI-MI slim synonym: "deacetylation" EXACT PSI-MI-short [] xref: MI:0197 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000007 name: defarnesylation reaction def: "S-farnesyl-L-cysteined is cleaved and returns a C residue." [PMID:14755292, RESID:AA0102] subset: PSI-MI slim synonym: "defarnesylation" EXACT PSI-MI-short [] xref: MI:0198 is_a: CCO:Y0000020 ! lipid cleavage [Term] id: CCO:Y0000008 name: deformylation reaction def: "N6-formyl-L-lysine is cleaved and returns a K residue." [PMID:14755292, RESID:AA0211] subset: PSI-MI slim synonym: "deformylation" EXACT PSI-MI-short [] xref: MI:0199 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000009 name: degeranylation reaction def: "S-geranylgeranyl-L-cysteine is cleaved and returns a C residue." [PMID:14755292, RESID:AA0104] subset: PSI-MI slim synonym: "degeranylation" EXACT PSI-MI-short [] xref: MI:0200 is_a: CCO:Y0000020 ! lipid cleavage [Term] id: CCO:Y0000010 name: demyristoylation reaction def: "N6-myristoyl-L-lysine is cleaved and returns a K residue." [PMID:14755292, RESID:AA0078] subset: PSI-MI slim synonym: "demyristoylation" EXACT PSI-MI-short [] xref: MI:0201 is_a: CCO:Y0000020 ! lipid cleavage [Term] id: CCO:Y0000011 name: depalmitoylation reaction def: "S-palmitoyl-L-cysteine, N6-palmitoyl-L-lysine, O-palmitoyl-L-threonine or O-palmitoyl-L-serine are cleaved and return C,K,T or S residues." [PMID:14755292, RESID:AA0060, RESID:AA0077, RESID:AA0106] subset: PSI-MI slim synonym: "depalmitoylation" EXACT PSI-MI-short [] xref: MI:0202 is_a: CCO:Y0000020 ! lipid cleavage [Term] id: CCO:Y0000012 name: dephosphorylation reaction def: "Phosphoresidues are cleaved and return D,C,H,S,T,Y or R residues." [GO:0016311, PMID:14755292, RESID:AA0033, RESID:AA0034, RESID:AA0035, RESID:AA0036, RESID:AA0037, RESID:AA0038, RESID:AA0039, RESID:AA0222] subset: PSI-MI slim synonym: "dephosphorylation" EXACT PSI-MI-short [] xref: MI:0203 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000013 name: deubiquitination reaction def: "Cleavage of the G-K bond and release of ubiquitin or ubiquitin like proteins." [GO:0016579, PMID:11583613, RESID:AA0125] subset: PSI-MI slim synonym: "deubiquitination" EXACT PSI-MI-short [] xref: MI:0204 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000014 name: farnesylation reaction def: "Reversible reaction that can affect C residue." [GO:0018347, PMID:14755292, RESID:AA0102] subset: PSI-MI slim synonym: "farnesylation" EXACT PSI-MI-short [] xref: MI:0206 is_a: CCO:Y0000019 ! lipid addition [Term] id: CCO:Y0000015 name: formylation reaction def: "Reaction that can affect K or G residues." [GO:0018256, PMID:14755292, RESID:AA0057, RESID:AA0211] subset: PSI-MI slim synonym: "formylation" EXACT PSI-MI-short [] xref: MI:0207 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000016 name: genetic interaction def: "Functional relationship among genes revealed by the phenotype of cells carrying combined mutations of those genes." [PMID:14755292] subset: PSI-MI slim xref: MI:0208 is_a: CCO:Y0000001 ! interaction type [Term] id: CCO:Y0000017 name: geranylgeranylation reaction def: "Reversible reaction that can affect C residue." [GO:0018348, PMID:14755292, RESID:AA0104] subset: PSI-MI slim synonym: "geranylgeranylation" EXACT PSI-MI-short [] xref: MI:0209 is_a: CCO:Y0000019 ! lipid addition [Term] id: CCO:Y0000018 name: hydroxylation reaction def: "Irreversible reaction that can affect K,P,Y or R residues." [GO:0018126, PMID:14755292, RESID:AA0028, RESID:AA0029, RESID:AA0030, RESID:AA0146, RESID:AA0215] subset: PSI-MI slim synonym: "hydroxylation" EXACT PSI-MI-short [] xref: MI:0210 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000019 name: lipid addition def: "Covalent or non covalent binding of lipid group on a protein residue." [GO:0006497, PMID:14755292] subset: PSI-MI slim xref: MI:0211 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000020 name: lipid cleavage def: "Cleavage of a lipid group covalently bound to a protein residue." [PMID:14755292] subset: PSI-MI slim xref: MI:0212 is_a: CCO:Y0000004 ! cleavage reaction [Term] id: CCO:Y0000021 name: methylation reaction def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Irreversible reaction that can affect A,G,M,F,P,C,R,N,Q,E,H,or K residues." [GO:0043414, PMID:14755292, RESID:AA0061, RESID:AA0062, RESID:AA0063, RESID:AA0064, RESID:AA0065, RESID:AA0066, RESID:AA0067, RESID:AA0068, RESID:AA0069, RESID:AA0070, RESID:AA0071, RESID:AA0072, RESID:AA0073, RESID:AA0074, RESID:AA0075, RESID:AA0076, RESID:AA0234, RESID:AA0272] subset: PSI-MI slim synonym: "methylation" EXACT PSI-MI-short [] xref: MI:0213 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000022 name: myristoylation reaction def: "Reaction that can affect K or G residues." [GO:0018319, PMID:14755292, RESID:AA0059, RESID:AA0078] subset: PSI-MI slim synonym: "myristoylation" EXACT PSI-MI-short [] xref: MI:0214 is_a: CCO:Y0000019 ! lipid addition [Term] id: CCO:Y0000023 name: palmitoylation reaction def: "Reversible reaction that can affect C,K,T or S residues." [GO:0018318, PMID:14755292, RESID:AA0060, RESID:AA0077, RESID:AA0079, RESID:AA0080, RESID:AA0106] subset: PSI-MI slim synonym: "palmitoylation" EXACT PSI-MI-short [] xref: MI:0216 is_a: CCO:Y0000019 ! lipid addition [Term] id: CCO:Y0000024 name: phosphorylation reaction def: "Reversible reaction that can affect D,C,H,S,T,Y,R residues." [GO:0016310, PMID:14755292, RESID:AA0033, RESID:AA0034, RESID:AA0035, RESID:AA0036, RESID:AA0037, RESID:AA0038, RESID:AA0039, RESID:AA0222] subset: PSI-MI slim synonym: "phosphorylation" EXACT PSI-MI-short [] xref: MI:0217 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000026 name: ubiquitination reaction def: "Reversible reaction that create a covalent bond between a C-terminus G of ubiquitin and a K residue of the target." [GO:0016567, PMID:11583613, RESID:AA0125] subset: PSI-MI slim synonym: "ubiquitination" EXACT PSI-MI-short [] xref: MI:0220 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000027 name: colocalization def: "Coincident occurrence of molecules in a given subcellular fraction observed with a low resolution methodology from which a physical interaction among those molecules cannot be inferred." [PMID:14755292] subset: PSI-MI slim xref: MI:0403 is_a: CCO:Y0000001 ! interaction type [Term] id: CCO:Y0000028 name: direct interaction def: "Interaction that is proven to involve only its interactors." [PMID:14755292] subset: PSI-MI slim xref: MI:0407 is_a: CCO:Y0000060 ! physical association [Term] id: CCO:Y0000029 name: disulfide bond def: "Covalent bond mediated by 2 sulfur atoms." [PMID:14755292] subset: PSI-MI slim xref: MI:0408 is_a: CCO:Y0000005 ! covalent binding [Term] id: CCO:Y0000030 name: enzymatic reaction def: "terms aiming to represent biochemical reactions referring to their resulting product modifications." [PMID:14755292] subset: PSI-MI slim synonym: "Biochemical reaction" EXACT PSI-MI-alternate [] xref: MI:0414 is_a: CCO:Y0000028 ! direct interaction [Term] id: CCO:Y0000031 name: transglutamination reaction def: "Gln-Lys cross-link catalyzed by a transglutaminase." [PMID:14755292, RESID:AA0124] subset: PSI-MI slim synonym: "transglutamination" EXACT PSI-MI-short [] xref: MI:0556 is_a: CCO:Y0000005 ! covalent binding [Term] id: CCO:Y0000032 name: adp ribosylation reaction def: "Reaction that can affect Arg, Cys, Glu, Arg and Asn residues." [GO:0006471, PMID:14755292, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295] subset: PSI-MI slim synonym: "adp ribosylation" EXACT PSI-MI-short [] xref: MI:0557 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000033 name: deglycosylation reaction def: "Reaction catalyzed by PNGase, a deglycosylating enzyme that promotes the hydrolysis of the beta-aspartylglycosylamine bond of aspargine-linked glycopeptides and glycoproteins." [GO:0006517, PMID:15670854] subset: PSI-MI slim synonym: "deglycosylation" EXACT PSI-MI-short [] xref: MI:0558 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000034 name: glycosylation reaction def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Reaction that can affect Ser, Thr, Cys, Arg, and Asn residues. This reaction is known to be reversible in the case of Asn substrate." [GO:0043413, PMID:14755292, RESID:AA0122, RESID:AA0151, RESID:AA0154, RESID:AA0155, RESID:AA0327] subset: PSI-MI slim synonym: "glycosylation" EXACT PSI-MI-short [] xref: MI:0559 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000035 name: sumoylation reaction def: "Reversible reaction that create a covalent bond between a C-terminus G of an ubiquitine like sumo protein and a K residue of the target." [GO:0016925, PMID:15985640] subset: PSI-MI slim synonym: "sumoylation" EXACT PSI-MI-short [] xref: MI:0566 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000036 name: neddylation reaction def: "Reversible reaction that create a covalent bond between a Glycine residue of an ubiquitine like NEDD8 protein and a lysine residue of the target." [GO:0045116, PMID:16127432] subset: PSI-MI slim synonym: "neddylation" EXACT PSI-MI-short [] xref: MI:0567 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000037 name: desumoylation reaction def: "Cleavage of the G-K bond and release of the SUMO ubiquitin like proteins." [GO:0016926, PMID:15985640] subset: PSI-MI slim synonym: "desumoylation" EXACT PSI-MI-short [] xref: MI:0568 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000038 name: deneddylation reaction def: "Cleavage of the G-K bond and release of the NEDD8 ubiquitin like proteins. Deneddylation, which removes the NEDD8 moiety, requires the isopeptidase activity of the COP9 signalosome." [GO:0000338, PMID:16127432] subset: PSI-MI slim synonym: "deneddylation" EXACT PSI-MI-short [] xref: MI:0569 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000039 name: protein cleavage def: "Covalent modification of a polypeptide occuring during its maturation or its proteolytic degradation." [PMID:14744292] subset: PSI-MI slim xref: MI:0570 is_a: CCO:Y0000004 ! cleavage reaction [Term] id: CCO:Y0000040 name: mrna cleavage def: "Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GO:0006379, PMID:14681407] subset: PSI-MI slim xref: MI:0571 is_a: CCO:Y0000057 ! rna cleavage [Term] id: CCO:Y0000041 name: dna cleavage def: "Covalent bond breakage of a DNA molecule leading to the formation of smaller fragments." [PMID:14755292] subset: PSI-MI slim xref: MI:0572 is_a: CCO:Y0000058 ! nucleic acid cleavage [Term] id: CCO:Y0000042 name: dna strand elongation def: "The process by which a DNA strand is synthesized from template DNA by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand." [GO:0006271, PMID:14755292] subset: PSI-MI slim synonym: "DNA replication elongation " EXACT PSI-MI-alternate [] synonym: "elongation" EXACT PSI-MI-short [] xref: MI:0701 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000043 name: synthetic interaction def: "The phenotype resulting from genetic perturbation A and the phenotype resulting from genetic perturbation B have no effect on the WT background, but the combined genetic perturbation of A and B has a phenotypic effect. " [PMID:15833125] subset: PSI-MI slim synonym: "synthetic" EXACT PSI-MI-short [] xref: MI:0794 is_a: CCO:Y0000016 ! genetic interaction [Term] id: CCO:Y0000044 name: asynthetic interaction def: "The phenotype resulting from genetic perturbation of A alone, B alone and AB combined have the same effect on the WT background." [PMID:15833125] subset: PSI-MI slim synonym: "asynthetic" EXACT PSI-MI-short [] xref: MI:0795 is_a: CCO:Y0000016 ! genetic interaction [Term] id: CCO:Y0000045 name: suppressive interaction def: "The phenotype resulting from genetic perturbation of A has an effect on WT, but that effect is abolished by adding the suppressor B, which itself shows no single-mutant effect (for example, WT = B = AB < A); " [PMID:15833125] subset: PSI-MI slim synonym: "suppression" EXACT PSI-MI-short [] xref: MI:0796 is_a: CCO:Y0000016 ! genetic interaction [Term] id: CCO:Y0000046 name: epistatic interaction def: "The phenotype resulting from genetic perturbation of A and B have different effects (in terms of direction or magnitude) on the wild-type background and the double mutant has the same phenotype as either A or B (for example, A < WT < B = AB)." [PMID:15833125] subset: PSI-MI slim synonym: "epistatic" EXACT PSI-MI-short [] xref: MI:0797 is_a: CCO:Y0000016 ! genetic interaction [Term] id: CCO:Y0000047 name: conditional interaction def: "The phenotype resulting from genetic perturbation of A has an effect only in the B background, or the B mutant has an effect only in the A background." [PMID:15833125] subset: PSI-MI slim synonym: "conditional" EXACT PSI-MI-short [] xref: MI:0798 is_a: CCO:Y0000016 ! genetic interaction [Term] id: CCO:Y0000048 name: additive interaction def: "Single-mutant phenotype effects combine to give a double-mutant effect different from the wild type and different from single mutant effect. For instance WT < A= B < AB, B < WT = AB < A, WT < A < B < AB, B < WT < AB < A, and all additional inequalities obtained by interchanging A and B, or reversing the effect of both A and B. " [PMID:15833125] subset: PSI-MI slim synonym: "additive" EXACT PSI-MI-short [] xref: MI:0799 is_a: CCO:Y0000016 ! genetic interaction [Term] id: CCO:Y0000049 name: single nonmonotonic interaction def: "The phenotype resulting from genetic perturbation of B shows opposing effects in the WT and A backgrounds (for example, B > WT and AB< A); or, A shows opposing effects in the WT and B backgrounds, but not both. " [PMID:15833125] subset: PSI-MI slim synonym: "single nonmonotonic" EXACT PSI-MI-short [] xref: MI:0800 is_a: CCO:Y0000016 ! genetic interaction [Term] id: CCO:Y0000050 name: double nonmonotonic interaction def: "The phenotype resulting from genetic perturbation of both A and B show opposing effects in the WT background and the background with the other mutant gene." [PMID:15833125] subset: PSI-MI slim synonym: "double nonmonotonic" EXACT PSI-MI-short [] xref: MI:0801 is_a: CCO:Y0000016 ! genetic interaction [Term] id: CCO:Y0000051 name: enhancement interaction def: "The A genetic perturbation enhances the phenotype of the B perturbation, or vice versa (e.g. WT = A < B < AB or WT = B < A < AB). This could be conditional or additive by the above scheme. " [PMID:15833125] subset: PSI-MI slim synonym: "enhancement" EXACT PSI-MI-short [] xref: MI:0802 is_a: CCO:Y0000047 ! conditional interaction is_a: CCO:Y0000048 ! additive interaction [Term] id: CCO:Y0000052 name: phosphotransfer reaction def: "Reaction where a phosphate is transferred between two proteins of a phosphorelay system. " [PMID:14755292, PMID:16712436] subset: PSI-MI slim synonym: "phosphotransfer" EXACT PSI-MI-short [] xref: MI:0844 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000053 name: demethylation reaction def: "The cleavage of a methyl group from a polypeptide. Methylation is generally an irreversible reaction except in mamalian." [GO:0006482, PMID:17277772] subset: PSI-MI slim synonym: "demethylation" EXACT PSI-MI-short [] xref: MI:0871 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000054 name: nucleoside triphosphatase reaction def: "Catalysis of the hydrolisis of a nucleoside triphosphate into a nucleoside diphosphate plus phosphate." [GO:0017111, PMID:14755292] subset: PSI-MI slim synonym: "triphosphatase react" EXACT PSI-MI-short [] xref: MI:0881 is_a: CCO:Y0000030 ! enzymatic reaction [Term] id: CCO:Y0000055 name: atpase reaction def: "Catalysis of the hydrolisis of ATP+ H2O = ADP + phosphate." [GO:0016887, PMID:14755292] subset: PSI-MI slim xref: MI:0882 is_a: CCO:Y0000054 ! nucleoside triphosphatase reaction [Term] id: CCO:Y0000056 name: gtpase reaction def: "Catalysis of the hydrolisis of GTP+ H2O = GDP + phosphate." [GO:0003924, PMID:14755292] subset: PSI-MI slim xref: MI:0883 is_a: CCO:Y0000054 ! nucleoside triphosphatase reaction [Term] id: CCO:Y0000057 name: rna cleavage def: "Any process by which an RNA molecule is cleaved at specific sites or in a regulated manner." [GO:0006396, PMID:14681407] subset: PSI-MI slim xref: MI:0902 is_a: CCO:Y0000058 ! nucleic acid cleavage [Term] id: CCO:Y0000058 name: nucleic acid cleavage def: "Covalent bond breakage of a nucleic acid molecule leading to the formation of smaller fragments." [PMID:14755292] subset: PSI-MI slim synonym: "ncl acid cleavage" EXACT PSI-MI-short [] xref: MI:0910 is_a: CCO:Y0000004 ! cleavage reaction [Term] id: CCO:Y0000059 name: association def: "Molecules that are experimentally shown to be associated potentially by sharing just one interactor. Often associated molecules are co-purified by a pull-down or coimmunoprecipitation and share the same bait molecule." [PMID:14755292] subset: PSI-MI slim xref: MI:0914 is_a: CCO:Y0000001 ! interaction type [Term] id: CCO:Y0000060 name: physical association def: "Molecules that are experimentally shown to belong to the same functional or structural complex." [PMID:14755292] subset: PSI-MI slim xref: MI:0915 is_a: CCO:Y0000059 ! association [Typedef] id: adjacent_to name: adjacent_to def: "C adjacent to C' if and only if: given any instance c that instantiates C at a time t, there is some c' such that: c' instantiates C' at time t and c and c' are in spatial proximity" [PMID:15892874] comment: Note that adjacent_to as thus defined is not a symmetric relation, in contrast to its instance-level counterpart. For it can be the case that Cs are in general such as to be adjacent to instances of C1 while no analogous statement holds for C1s in general in relation to instances of C. Examples are: nuclear membrane adjacent_to cytoplasm; seminal vesicle adjacent_to urinary bladder; ovary adjacent_to parietal pelvic peritoneum xref: OBO_REL:adjacent_to is_a: relationship ! relationship [Typedef] id: agent_in name: agent_in xref: OBO_REL:agent_in is_a: participates_in ! participates_in [Typedef] id: association name: association def: "C in association with C' produces C'' if and only if for all c belonging to C and c' belongin to C', exists a c'' (belonging to C'') which is the result of the reversible union between c and c'." [CCO:ea] comment: Ternary relationship. See http://www.w3.org/TR/swbp-n-aryRelations/ for the OWL equivalent. The dissociation is a reversible splitting into simpler entities. xref: CCO_REL:association is_a: relationship ! relationship [Typedef] id: catalyses name: catalyses def: "C catalyses P if and only if for all c (catalyst) belonging to C, exists a p (belonging to P) which chemical reaction rate is increased by c." [CCO:ea] comment: C inhibits P if and only if for all c (inhibitor) belonging to C, exists a p (belonging to P) which chemical reaction rate is reduced or prevented by c. synonym: "activates" EXACT [] xref: CCO_REL:catalyses is_a: relationship ! relationship [Typedef] id: codes_for name: codes_for def: "g encodes for p where g a Gene and p is a Protein." [CCO:ea] synonym: "encodes" EXACT [CCO:ea] xref: CCO_REL:codes_for is_a: relationship ! relationship [Typedef] id: contained_in name: contained_in def: "C contained_in C' if and only if: given any instance c that instantiates C at a time t, there is some c' such that: c' instantiates C' at time t and c located_in c' at t, and it is not the case that c *overlaps* c' at t. (c' is a conduit or cavity.)" [PMID:15892874] comment: Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition): xref: OBO_REL:contained_in is_a: relationship ! relationship [Typedef] id: contains name: contains xref: OBO_REL:contains is_a: relationship ! relationship [Typedef] id: degradates name: degradates def: "C is degradated (into NIL) if and only if for all c belonging to C, exists c', c'', ... (belonging to C', C'', ...) which are the result of any undesired breakdown of c with impairment or loss of its characteristic properties." [CCO:ea] comment: NIL entity must be created. synonym: "decomposition" EXACT [] synonym: "catabolism" EXACT [] xref: CCO_REL:degradates is_a: relationship ! relationship [Typedef] id: derived_into name: derived_into xref: OBO_REL:derived_into is_transitive: true is_a: relationship ! relationship [Typedef] id: derives_from name: derives_from def: "Derivation on the instance level (*derives_from*) holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. We say that one class C derives_from class C' if instances of C are connected to instances of C' via some chain of instance-level derivation relations. Example: osteocyte derives_from osteoblast. Formally: C derives_immediately_from C' if and only if: given any c and any t, if c instantiates C at time t, then there is some c' and some t', such that c' instantiates C' at t' and t' earlier-than t and c *derives_from* c'. C derives_from C' if and only if: there is an chain of immediate derivation relations connecting C to C'." [PMID:15892874] comment: Derivation as a relation between instances. The temporal relation of derivation is more complex. Transformation, on the instance level, is just the relation of identity: each adult is identical to some child existing at some earlier time. Derivation on the instance-level is a relation holding between non-identicals. More precisely, it holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. Thus we will have axioms to the effect that from c derives_from c1 we can infer that c and c1 are not identical and that there is some instant of time t such that c1 exists only prior to and c only subsequent to t. We will also be able to infer that the spatial region occupied by c as it begins to exist at t overlaps with the spatial region occupied by c1 as it ceases to exist in the same instant. synonym: "derived_from" EXACT [] xref: OBO_REL:derives_from is_transitive: true is_a: relationship ! relationship [Typedef] id: encoded_by name: encoded_by def: "p is encoded by g where p is a Protein and g a Gene." [CCO:ea] synonym: "is_produced_by" EXACT [CCO:ea] synonym: "coded_by" EXACT [CCO:ea] xref: CCO_REL:encoded_by is_a: relationship ! relationship [Typedef] id: has_agent name: has_agent def: "As for has_participant, but with the additional condition that the component instance is causally active in the relevant process" [PMID:15892874] xref: OBO_REL:has_agent is_a: has_participant ! has_participant [Typedef] id: has_function name: has_function def: "P has_function F where P is a protein and F a molecular function" [CCO:ea] xref: CCO_REL:has_function is_a: relationship ! relationship [Typedef] id: has_improper_part name: has_improper_part comment: See reasons for obsoletion of improper_part_of xref: OBO_REL:has_improper_part is_reflexive: true is_transitive: true is_a: has_part ! has_part is_obsolete: true [Typedef] id: has_integral_part name: has_integral_part xref: OBO_REL:has_integral_part is_anti_symmetric: true is_reflexive: true is_transitive: true is_a: has_part ! has_part [Typedef] id: has_part name: has_part xref: OBO_REL:has_part is_anti_symmetric: true is_reflexive: true is_transitive: true is_a: relationship ! relationship [Typedef] id: has_participant name: has_participant def: "P has_participant C if and only if: given any process p that instantiates P there is some continuant c, and some time t, such that: c instantiates C at t and c participates in p at t" [PMID:15892874] comment: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. xref: OBO_REL:has_participant is_a: relationship ! relationship [Typedef] id: has_proper_part name: has_proper_part xref: OBO_REL:has_proper_part is_transitive: true is_a: has_part ! has_part [Typedef] id: has_source name: has_source def: "o has_source O where o is a gene or gene product and O an organism." [CCO:ea] xref: CCO_REL:has_source is_a: relationship ! relationship [Typedef] id: improper_part_of name: improper_part_of def: "As for part_of, with the additional constraint that subject and object may be identical" [PMID:15892874] comment: OBSOLETE. The definition is "As for part_of, with the additional constraint that subject and object may be identical". However, part_of is already reflexive, therefore improper_part_of is identical to part_of. If read differently, as "improper_part_of is part_of but not proper_part_of",improper_part_of becomes identity. So, improper_part_of is either identical to part_of or to identity, and not an intuitive synonym for either of them. [Robert Hoehndorf] xref: OBO_REL:improper_part_of is_reflexive: true is_transitive: true is_a: part_of ! part_of is_obsolete: true [Typedef] id: instance_of name: instance_of builtin: true def: "A relation between an instance and a class. For components: a primitive relation between a component instance and a class which it instantiates at a specific time. For processes: a primitive relation, between a process instance and a class which it instantiates, holding independently of time" [PMID:15892874] comment: The instance_of relationship is considered axiomatic by the obo file format specification; ie it is taken for granted. The is_a relation is still included in this ontology for completeness xref: OBO_REL:instance_of is_a: relationship ! relationship [Typedef] id: integral_part_of name: integral_part_of def: "C integral_part_of C' if and only if: C part_of C' AND C' has_part C" [PMID:15892874] xref: OBO_REL:integral_part_of is_anti_symmetric: true is_reflexive: true is_transitive: true is_a: part_of ! part_of [Typedef] id: interacts_with name: interacts_with def: "C interacts_with C' if and only if for all c belonging to C, exists a c' (belonging to C') which plays a role with c'." [CCO:ea] xref: CCO_REL:interacts_with is_symmetric: true is_transitive: true is_a: relationship ! relationship [Typedef] id: is_a name: is_a [Typedef] id: located_in name: located_in def: "C located_in C' if and only if: given any c that instantiates C at a time t, there is some c' such that: c' instantiates C' at time t and c *located_in* c'. (Here *located_in* is the instance-level location relation.)" [PMID:15892874] comment: Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus xref: OBO_REL:located_in is_reflexive: true is_transitive: true is_a: relationship ! relationship [Typedef] id: location_of name: location_of xref: OBO_REL:location_of is_reflexive: true is_transitive: true is_a: relationship ! relationship [Typedef] id: negatively_regulates name: negatively_regulates [Typedef] id: part_of name: part_of xref: OBO_REL:part_of is_transitive: true [Typedef] id: participates_in name: participates_in def: "C participates_in P if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in xref: OBO_REL:participates_in is_a: relationship ! relationship [Typedef] id: participates_in(IC) name: participates_in(IC) def: "C participates_in P (Inferred by Curator) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(IC) is_a: participates_in ! participates_in [Typedef] id: participates_in(IDA) name: participates_in(IDA) def: "C participates_in P (Inferred from Direct Assay) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(IDA) is_a: participates_in ! participates_in [Typedef] id: participates_in(IEA) name: participates_in(IEA) def: "C participates_in P (Inferred from Electronic Annotation) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(IEA) is_a: participates_in ! participates_in [Typedef] id: participates_in(IEP) name: participates_in(IEP) def: "C participates_in P (Inferred from Expression Pattern) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(IEP) is_a: participates_in ! participates_in [Typedef] id: participates_in(IGC) name: participates_in(IGC) def: "C participates_in P (Inferred from Genomic Context) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(IGC) is_a: participates_in ! participates_in [Typedef] id: participates_in(IGI) name: participates_in(IGI) def: "C participates_in P (Inferred from Genetic Interaction) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(IGI) is_a: participates_in ! participates_in [Typedef] id: participates_in(IMP) name: participates_in(IMP) def: "C participates_in P (Inferred from Mutant Phenotype) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(IMP) is_a: participates_in ! participates_in [Typedef] id: participates_in(IPI) name: participates_in(IPI) def: "C participates_in P (Inferred from Physical Interaction) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(IPI) is_a: participates_in ! participates_in [Typedef] id: participates_in(ISS) name: participates_in(ISS) def: "C participates_in P (Inferred from Sequence or Structural Similarity) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(ISS) is_a: participates_in ! participates_in [Typedef] id: participates_in(NAS) name: participates_in(NAS) def: "C participates_in P (Non-traceable Author Statement) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(NAS) is_a: participates_in ! participates_in [Typedef] id: participates_in(ND) name: participates_in(ND) def: "C participates_in P (No biological Data available) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(ND) is_a: participates_in ! participates_in [Typedef] id: participates_in(NR) name: participates_in(NR) def: "C participates_in P (Not Recorded) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(NR) is_a: participates_in ! participates_in is_obsolete: true [Typedef] id: participates_in(RCA) name: participates_in(RCA) def: "C participates_in P (inferred from Reviewed Computational Analysis) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(RCA) is_a: participates_in ! participates_in [Typedef] id: participates_in(TAS) name: participates_in(TAS) def: "C participates_in P (Traceable Author Statement) if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea] xref: CCO_REL:participates_in(TAS) is_a: participates_in ! participates_in [Typedef] id: positively_regulates name: positively_regulates [Typedef] id: preceded_by name: preceded_by def: "P preceded_by P' if and only if: given any process p that instantiates P at a time t, there is some process p' such that p' instantiates P' at time t', and t' is earlier than t. " [PMID:15892874] comment: An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. xref: OBO_REL:preceded_by is_transitive: true is_a: relationship ! relationship [Typedef] id: precedes name: precedes xref: OBO_REL:precedes is_transitive: true is_a: relationship ! relationship [Typedef] id: proper_part_of name: proper_part_of def: "As for part_of, with the additional constraint that subject and object are distinct" [PMID:15892874] xref: OBO_REL:proper_part_of is_transitive: true is_a: part_of ! part_of [Typedef] id: regulates name: regulates [Typedef] id: relationship name: relationship def: "A relationship between two classes (terms). Relationships between classes are expressed in terms of relations on underlying instances." [] xref: OBO_REL:relationship [Typedef] id: source_of name: source_of def: "O is source_of o where O is an organism and o a gene or gene product." [CCO:ea] xref: CCO_REL:source_of is_a: relationship ! relationship [Typedef] id: transformation_of name: transformation_of def: "Relation between two classes, in which instances retain their identity yet change their classification by virtue of some kind of transformation. Formally: C transformation_of C' if and only if given any c and any t, if c instantiates C at time t, then for some t', c instantiates C' at t' and t' earlier t, and there is no t2 such that c instantiates C at t2 and c instantiates C' at t2." [PMID:15892874] comment: When an embryonic oenocyte (a type of insect cell) is transformed into a larval oenocyte, one and the same continuant entity preserves its identity while instantiating distinct classes at distinct times. The class-level relation transformation_of obtains between continuant classes C and C1 wherever each instance of the class C is such as to have existed at some earlier time as an instance of the distinct class C1 (see Figure 2 in paper). This relation is illustrated first of all at the molecular level of granularity by the relation between mature RNA and the pre-RNA from which it is processed, or between (UV-induced) thymine-dimer and thymine dinucleotide. At coarser levels of granularity it is illustrated by the transformations involved in the creation of red blood cells, for example, from reticulocyte to erythrocyte, and by processes of development, for example, from larva to pupa, or from (post-gastrular) embryo to fetus or from child to adult. It is also manifest in pathological transformations, for example, of normal colon into carcinomatous colon. In each such case, one and the same continuant entity instantiates distinct classes at different times in virtue of phenotypic changes. xref: OBO_REL:transformation_of is_transitive: true is_a: relationship ! relationship [Typedef] id: transforms_into name: transforms_into xref: CCO_REL:transforms_into is_transitive: true is_a: relationship ! relationship